title: Incidence, pathophysiology and prognosis of exercise-induced sustained ventricular tachycardia associated with healed myocardial infarction.
abstract: Of 150 consecutive patients with sustained monomorphic ventricular tachycardia (VT) (n = 116) or ventricular fibrillation (VF) (n = 34) late after acute myocardial infarction, 17 had reproduction of their sustained monomorphic VT during exercise testing. Data from these patients (group I) were compared with data from patients without exercise-induced VT (group II). No statistical difference was found between groups I and II with relation to age, sex, number of vessels with greater than 70% stenosis, left ventricular ejection fraction, number of previous myocardial infarctions, inducibility during programmed stimulation and total mortality during follow-up. In group I, only 1 patient (6%) developed ST depression during exercise compared with 47 patients (35%) in group II (p less than 0.01). After a 34-month mean follow-up, 6 patients in group I (35%) and 18 patients in group II (13%) died suddenly (p = 0.02). It is concluded that sustained monomorphic VT is reproduced during exercise in only 11% of patients with spontaneous late sustained monomorphic VT or VF. Electrocardiographic findings do not support ischemia as a triggering mechanism of exercise-induced sustained monomorphic VT. Patients with exercise-induced sustained monomorphic VT have a high incidence of sudden death.
authors.affiliation: Department of Cardiology, Centre Hospitalier Universitaire, Liège, Belgium.
authors.forename: G E
authors.initials: GE
authors.lastname: O'Hara
authors.forename: P
authors.initials: P
authors.lastname: Brugada
authors.forename: L M
authors.initials: LM
authors.lastname: Rodriguez
authors.forename: M
authors.initials: M
authors.lastname: Brito
authors.forename: L
authors.initials: L
authors.lastname: Mont
authors.forename: A
authors.initials: A
authors.lastname: Waleffe
authors.forename: H
authors.initials: H
authors.lastname: Kulbertus
authors.forename: H J
authors.initials: HJ
authors.lastname: Wellens
mesh_terms: D017023:Coronary Angiography; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D011379:Prognosis; D013610:Tachycardia / Q000209:etiology / Q000503:physiopathology*