Antioxidative activity of synthetic melanins. Cardiolipin liposome model.
The inhibiting effect of melanin synthesized from dihydroxyphenylalanine (DOPA), dopamine, adrenaline and adrenolutin on the ultraviolet- or the Fe(2+)-ascorbic acid-induced peroxidation of cardiolipin liposomes has been studied. All these melanins are able to inhibit both the ultraviolet- and the Fe(2+)-ascorbic acid-induced lipid peroxidation. Antioxidative activity of melanins enhances in the order: dopamine-melanin less than melanin synthesized from dopamine in the presence of Cu(2+) less than DOPA--melanin less than melanin synthesized from adrenaline in the presence of Cu(2+) approximately equal to adrenolutin-melanin, and correlates with their ability to scavenge superoxide anion radical. The optical screening effect of the investigated melanins in the inhibition of lipid peroxidation was not higher than 15% for the most active melanins.
Porebska-Budny
M
M
Department of Biochemistry and Biophysics, Silesian Medical Academy, Sosnowiec, Poland.
Sakina
N L
NL
Stepień
K B
KB
Dontsov
A E
AE
Wilczok
T
T
D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid; D002308:Cardiolipins / Q000737:chemistry* / Q000528:radiation effects; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004298:Dopamine / Q000031:analogs & derivatives / Q000494:pharmacology; D004837:Epinephrine / Q000031:analogs & derivatives / Q000494:pharmacology; D005296:Ferrous Compounds; D007211:Indoles / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008081:Liposomes / Q000737:chemistry*; D008543:Melanins / Q000138:chemical synthesis / Q000494:pharmacology*; D009580:Nitroblue Tetrazolium / Q000737:chemistry; D010777:Photochemistry; D014466:Ultraviolet Rays
D000975:Antioxidants; D002308:Cardiolipins; D005296:Ferrous Compounds; D007211:Indoles; D008081:Liposomes; D008543:Melanins; C051140:iron(II)-ascorbic acid complex; C014121:neuromelanin; C054791:adrenolutin; D009580:Nitroblue Tetrazolium; D004295:Dihydroxyphenylalanine; C040616:DOPA melanin; D001205:Ascorbic Acid; D004298:Dopamine; D004837:Epinephrine