[Evaluation of repeated hepatic dearterialization combined with intra-arterial infusion chemotherapy of unresectable primary or secondary cancer of the liver].
Repeated hepatic dearterialization combined with intra-arterial infusion chemotherapy was performed in 29 patients with unresectable primary or secondary cancer of the liver. Partial Response (PR) was obtained in 4 cases (1 hepatocellular carcinoma and 3 gastric secondaries), when evaluated by measuring the regression rate radiologically. The most remarkable effect was found in those with metastases from gastric cancer. A satisfactory result was not obtained for hepatocellular carcinoma with liver cirrhosis because of frequent associated complications. A strategy to modulate the resistance of tumors to ischemia and anticancer drugs should be considered in order to obtain a better clinical result by this method.
Makino
Y
Y
2nd Dept. of Surgery, Shimane Medical University.
Nagasue
N
N
Kohno
H
H
Taniura
H
H
Hayashi
T
T
Uchida
M
M
Ohiwa
K
K
Takemoto
Y
Y
Kimoto
T
T
Ono
T
T
D002404:Catheterization / Q000295:instrumentation*; D002408:Catheters, Indwelling; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology; D015996:Survival Rate
D015251:Epirubicin; D016685:Mitomycin; D004317:Doxorubicin