title: Second-order approximations for selection coefficients at polygenic loci. II. Pleiotropy.
abstract: I determine the second-order approximation for the phenotypic distribution of an arbitrary number of quantitative traits, ignoring the effects of epistasis and linkage disequilibrium, conditioned on the presence of a specified genotype at one underlying locus of small effect. Using this approximation, I determine formulae for the effects of selection at a single locus with random mating under either Gaussian stabilizing selection, or correlated selection with truncation selection for one character. These formulae apply for arbitrary phenotypic distributions, yet even with multivariate Gaussian distributions of phenotypic effects the formula for correlated selection includes a correction to the standard formula in Falconer (1989). I demonstrate that this approximation has an error that is third order in the allelic or genotypic effects, independent of the form of the phenotypic distribution. I show also that the approximation of analogous form for the phenotypic distribution conditioned on the presence of a specified allele at a single locus is also correct to second order. Both approximations allow for dominance and are consistent in the sense that computing marginal fitnesses from approximations based on genotypic deviations and those based on average allelic effect yield the same answers.
authors.affiliation: Division of Environmental Studies, University of California, Davis 95616.
authors.forename: A
authors.initials: A
authors.lastname: Hastings
mesh_terms: D005838:Genotype; D008433:Mathematics; D008957:Models, Genetic; D015233:Models, Statistical; D010641:Phenotype; D012641:Selection, Genetic