title: Factors influencing local relapse and survival and results of salvage treatment after breast-conserving therapy in operable breast cancer: EORTC trial 10801, breast conservation compared with mastectomy in TNM stage I and II breast cancer.
abstract: A (modified) radical mastectomy (RM) was compared with breast-conserving therapy (BCT) in stage I and stage II breast cancer patients. Treatment of the study arm comprised lumpectomy, axillary clearance and radiotherapy to the breast (50 Gy in 5 weeks external irradiation and a boost with iridium implant of 25 Gy). 902 patients were included. There were 734 TNM stage II patients. Patients with microscopically incomplete excision of the tumour were not excluded. After a median follow-up of 6 years, overall survival and local recurrence rates do not differ significantly between the two study arms. Actuarial survival at 8 years was 73% after RM and 71% after BCT; actuarial local recurrence at 8 years was 9% and 15%, respectively. In the mastectomy group tumour size did not affect local relapse, but after BCT the incidence of local recurrences was higher for tumours of 2-5 cm (16%) than for smaller tumours (7%) (at 8 years, P = 0.08). Results of salvage treatment for local recurrence so far were similar in both the BCT and the mastectomy group.
authors.affiliation: Department of Surgery, The Netherlands Cancer Institute, Amsterdam.
authors.forename: J A
authors.initials: JA
authors.lastname: van Dongen
authors.forename: H
authors.initials: H
authors.lastname: Bartelink
authors.forename: I S
authors.initials: IS
authors.lastname: Fentiman
authors.forename: T
authors.initials: T
authors.lastname: Lerut
authors.forename: F
authors.initials: F
authors.lastname: Mignolet
authors.forename: G
authors.initials: G
authors.lastname: Olthuis
authors.forename: E
authors.initials: E
authors.lastname: van der Schueren
authors.forename: R
authors.initials: R
authors.lastname: Sylvester
authors.forename: D
authors.initials: D
authors.lastname: Tong
authors.forename: J
authors.initials: J
authors.lastname: Winter
mesh_terms: D000375:Aging / Q000502:physiology; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D015411:Mastectomy, Modified Radical; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D011379:Prognosis; D016879:Salvage Therapy; D013997:Time Factors