Review of selenite cataract.
Recent advances in understanding the mechanism of selenite cataract have resulted from locating the cleavage sites on proteolyzed beta-crystallins from the cataract, mimicking the insolubilization of crystallins found in the cataract in an in vitro system, studying cataract produced in lenses cultured in selenite, and permanently or temporarily reducing the rate formation of selenite cataract by use of various inhibitors. The present review discusses the selenite cataract as a useful model for understanding the role calcium-induced proteolysis in cataract formation.
Shearer
T R
TR
Department of Oral Biochemistry, School of Dentistry, Oregon Health Sciences University, Portland 97201.
David
L L
LL
Anderson
R S
RS
Azuma
M
M
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000378:metabolism; D002386:Cataract / Q000378:metabolism* / Q000473:pathology; D003459:Crystallins / Q000378:metabolism; D004195:Disease Models, Animal; D007908:Lens, Crystalline / Q000378:metabolism; D008969:Molecular Sequence Data; D012643:Selenium / Q000378:metabolism
D003459:Crystallins; D002154:Calpain; D012643:Selenium; D002118:Calcium