Mapping of the human VLA-alpha 4 gene to chromosome 2q31-q32.
The integrin VLA-4 (alpha 4: beta 1; CD49d/CD29) is involved in both cellular adhesion to extracellular matrix and cell-cell interactions. We have determined that the human gene coding for VLA-alpha 4 is located on the long arm of chromosome 2 by using fluorescence in situ hybridization. The VLA-alpha 4 gene has been more precisely mapped to the 2q31-q32 region after GTG banding (G-bands by trypsin using Giemsa). These data suggest that the VLA-4 gene belongs to the COL3A1-(ELN-FN)-COL6A3 linkage group and establishes a potential genetic relationship between the alpha 4 and alpha v integrin subunits.
Fernández-Ruiz
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E
Servicio de Inmunologia, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.
Pardo-Manuel de Villena
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F
Rubio
M A
MA
Corbí
A L
AL
Rodriguez de Córdoba
S
S
Sánchez-Madrid
F
F
D002448:Cell Adhesion; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D039001:Integrin alpha Chains; D008856:Microscopy, Fluorescence; D009693:Nucleic Acid Hybridization; D016029:Receptors, Very Late Antigen / Q000235:genetics*
C063493:CDw49d; D039001:Integrin alpha Chains; D016029:Receptors, Very Late Antigen