Cytotoxicity and DNA binding studies of several platinum (II) and palladium (II) complexes of the 2,2'-bipyridine and an anion of 2-pyridinecarboxylic/2-pyrazinecarboxylic acid.
Four water soluble complexes of the type [M(bpy)(a-x)]NO3, where M is Pd(II) or Pt(II), bpy is 2,2-bipyridine, and a-x is anion of 2-pyridinecarboxylic acid or 2-pyrazinecarboxylic acid, have been found to bind calf thymus DNA, possibly through hydrogen binding. [M(bpy)(2-py)]NO3 complexes (2-py is an anion of 2-pyridinecarboxylic acid) show I.D.50 values smaller than cisplatin whereas [M(bpy)(2-pyz)]NO3 complexes (2-pyz is an anion of 2-pyrazinecarboxylic acid) show I.D.50 values larger than cisplatin against P388 cancer cells.
Mansuri-Torshizi
H
H
Department of Chemistry, Indian Institute of Technology, Bombay.
Srivastava
T S
TS
Chavan
S J
SJ
Chitnis
M P
MP
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives*; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000627:therapeutic use; D002417:Cattle; D002945:Cisplatin / Q000378:metabolism / Q000627:therapeutic use; D004247:DNA / Q000378:metabolism*; D007941:Leukemia P388 / Q000188:drug therapy; D010165:Palladium / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D010984:Platinum / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use; D011719:Pyrazines / Q000378:metabolism* / Q000627:therapeutic use; D011725:Pyridines / Q000378:metabolism* / Q000627:therapeutic use; D013053:Spectrophotometry
D000970:Antineoplastic Agents; D011719:Pyrazines; D011725:Pyridines; D010984:Platinum; D015082:2,2'-Dipyridyl; D010165:Palladium; D004247:DNA; D002945:Cisplatin