title: The glycine-site NMDA receptor antagonist, R-(+)-cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one, L-687,414 is anticonvulsant in baboons.
abstract: The glycine-site NMDA receptor antagonist, R-(+)cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one (L-687,414) was administered i.t. to photosensitive baboons. The anticonvulsant action of L-687,414 (5-45 mg kg-1) was dose-dependent and peaked between 15 min and 2 h after administration. Gross behavioural effects were not observed at the doses tested. L-687,414 is a potent systemically acting anticonvulsant apparently devoid of serious side effects.
authors.affiliation: Department of Neurology, Institute of Psychiatry, London, U.K.
authors.forename: S E
authors.initials: SE
authors.lastname: Smith
authors.forename: B S
authors.initials: BS
authors.lastname: Meldrum
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D009207:Myoclonus / Q000188:drug therapy; D010215:Papio; D010775:Photic Stimulation; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
chemical_list: D000927:Anticonvulsants; D016194:Receptors, N-Methyl-D-Aspartate