Toxicity of a new dosage format, cisplatin incorporated in lactic acid oligomer microspheres, in mice.
A new drug delivery system, cisplatin incorporated into lactic acid oligomer microspheres (CDDP-MS), was developed for the treatment of peritoneal carcinomatoses. We studied the acute toxicity and pathological effects of CDDP-MS injected intraperitoneally in mice. The 50% lethal dose was 23.8 mg/kg (21.3-26.7 mg/kg at 95% level of confidence), which was 1.76 times that of the cisplatin aqueous solution of 13.5 mg/kg (11.9-15.3 mg/kg at 95% level of confidence). The duration for the restoration of the body weight loss was prolonged when CDDP-MS at doses close to the 50% lethal dose was administered, as compared with the cisplatin aqueous solution at doses close to its 50% lethal dose. On autopsy there were no macroscopic or microscopic differences between the two dosage forms.
Hagiwara
A
A
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Takahashi
T
T
Sasabe
T
T
Ito
M
M
Lee
M
M
Sakakura
C
C
Shobayashi
S
S
Muranishi
S
S
Tashima
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D008815:Mice, Inbred Strains; D008863:Microspheres; D009929:Organ Size / Q000187:drug effects; D011091:Polyesters / Q000737:chemistry
D011091:Polyesters; C033616:poly(lactide); D002945:Cisplatin