title: Liquid chromatographic estimation of tranylcypromine in human plasma.
abstract: A simple, selective and quantitative estimation of tranylcypromine using liquid chromatography and electrochemical detection with apomorphine as internal standard in human plasma is described. Sample preparation is done by liquid-liquid extraction. The absolute mean recovery of apomorphine is 95%, the recovery of tranylcypromine is 81%. This method gives a simple estimation method to assay plasma concentrations of tranylcypromine in the therapeutic range (5-200 ng/ml) with good reproducibility and linearity.
authors.affiliation: Medisch Spectrum Twente, Department of Clinical Pharmacy, Enschede, The Netherlands.
authors.forename: P G
authors.initials: PG
authors.lastname: Krugers Dagneaux
authors.forename: C P
authors.initials: CP
authors.lastname: Loohuis
authors.forename: J T
authors.initials: JT
authors.lastname: Klein Elhorst
authors.forename: T S
authors.initials: TS
authors.lastname: Van der Veer
mesh_terms: D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014191:Tranylcypromine / Q000097:blood*
chemical_list: D014191:Tranylcypromine