Circadian variation in total plasma tryptophan. Antidepressant treatment: drugs and phase advance.
The authors investigated hourly total plasma tryptophan concentrations over a 24 hour period in 3 patients with bipolar depression during 2 types of treatment: a phase advance process and conventional antidepressant therapy. Both treatment modalities increased the 24 hour mean tryptophan levels and the amplitude of circadian tryptophan concentrations. By contrast, in a previous study, moderately decreased tryptophan levels and a blunted amplitude in the circadian rhythm were observed in these same patients in a depressive phase.
Candito
M
M
Laboratoire de Biochimie, Hôpital Pasteur, Nice, France.
Pringuey
D
D
Iordache
A
A
Souêtre
E
E
Chambon
P
P
Darcourt
G
G
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008803:Mianserin / Q000627:therapeutic use*; D008875:Middle Aged; D014364:Tryptophan / Q000097:blood*; D014745:Viloxazine / Q000627:therapeutic use*
D008803:Mianserin; D014745:Viloxazine; D014364:Tryptophan