[Ca2+] and [Na+] in rat ventricular myocytes showing negative and positive force frequency relationships.
Ventricular cells that show a positive force-frequency relationship show graded changes of intracellular [Ca2+] (Cai), [Na+] (Nai) and sarcoplasmic reticulum Ca2+ content with changes of stimulation frequency. Cells that show a negative force-frequency relationship show smaller changes of Nai and no change in the Ca2+ load of the sarcoplasmic reticulum as stimulation frequency is changed.
Frampton
J E
JE
Department of Physiology, University of Leeds, U.K.
Harrison
S M
SM
Orchard
C H
CH
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
D012964:Sodium; D002118:Calcium