title: [Evaluation of the efficacy of the combination amoxicillin-clavulanic acid-tobramycin for the prevention of infections after surgery for ORL cancers].
abstract: The clinic and economic evaluation of a probabilist antibiotherapy Augmentin/Nebcine administered until the wound healing was studied in 60 patients, operated of upper aerodigestives tracts cancer. The antibiotherapy efficiency was estimated at the end of 6 days in terms of clinic and bacteriologic results. In case of therapeutic failure, the treatment was adapted according to antibiogram results. The association Augmentin/Nebcine was effective in 93% of cases. Antibiotherapy was to be modified for five patients (one for allergy and four for bacteriological unsuccessful). The bacteriologic sample shows the predominance of Gram(-) germs. 83% of them were sensitive to one of these antibiotics in vitro. The daily mean cost of antibiotherapy was about FF 71. The overcost, due to antibiotherapy failures, represented only 1% of the whole cost of the 60 treatments. These results justify the use of a large spectrum antibiotherapy reaching Gram(-) germs.
authors.affiliation: Service Pharmacie, CHR de Bordeaux, Pessac.
authors.forename: V
authors.initials: V
authors.lastname: Philip
authors.forename: M C
authors.initials: MC
authors.lastname: Saux
authors.forename: H
authors.initials: H
authors.lastname: Rovira
authors.forename: F
authors.initials: F
authors.lastname: Boutin
authors.forename: L
authors.initials: L
authors.lastname: Traissac
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D002969:Clavulanic Acids / Q000627:therapeutic use*; D002985:Clinical Protocols; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D014031:Tobramycin / Q000627:therapeutic use*
chemical_list: D002969:Clavulanic Acids; D000658:Amoxicillin; D014031:Tobramycin
vernacular_title: Evaluation de l'efficacité de l'association amoxicilline acide clavulanique-tobramycine pour la prévention des infections après chirurgie ORL pour cancer.