title: Modulation of ovarian carcinoma OV632 antigen by interferons.
abstract: Interferons are known to modulate several cellular functions by the induction of different proteins. In our study interferon-gamma and -alpha augmented presentation of one specific ovarian cancer antigen recognized by the antibody OV632 on the cell surface on one of four ovarian carcinoma cell lines in vitro (HTB-77). The interferon-gamma effect reached a maximum after 24 of treatment. Both HLA-DR and OV632 antigen expression were increased by interferon-gamma on HTB-77 cells whereas the two cell lines OVCAR-3 and 2780, which respond to an interferon-gamma treatment with a reduced proliferation and induction of HLA-DR, and also the interferon-resistant CRL-1572 were found to be resistant regarding OV632 epitope modulation. The demonstration of OV632 expression provides an important insight into the potential regulatory mechanism governing this tumor marker.
authors.affiliation: Department of Obstetrics and Gynecology, Innsbruck University Clinic, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Marth
authors.forename: E
authors.initials: E
authors.lastname: Müller-Holzner
authors.forename: I
authors.initials: I
authors.lastname: Gaugg
authors.forename: G
authors.initials: G
authors.lastname: Daxenbichler
authors.forename: O
authors.initials: O
authors.lastname: Dapunt
mesh_terms: D000951:Antigens, Neoplasm / Q000187:drug effects*; D000954:Antigens, Surface / Q000187:drug effects*; D016207:Cytokines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000276:immunology*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D016207:Cytokines; D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma