Deoxyribonucleic acid study on 2 XX male patients.
Two XX male patients were examined for the presence of 25 Y-specific loci using Southern blot analysis and polymerase chain reaction techniques. They were phenotypically normal male patients, although 1 had bilateral undescended testes and 1 had hypoplastic testes. The former patient had 10 of 11 loci on the short arm, while the latter lacked any of the 25 Y-specific loci. These findings may suggest the existence of a non-Y gene that is controlled by the testis-determining factor on the short arm of the Y chromosome and has a role in the testis formation in man.
Namiki
M
M
Department of Urology, Osaka University Medical School, Japan.
Uchida
K
K
Okuyama
A
A
Nagafuchi
S
S
Tamura
T
T
Nakagome
Y
Y
D000328:Adult; D002648:Child; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009030:Mosaicism / Q000235:genetics*; D014960:X Chromosome
D004247:DNA