title: Cardioprotective effect of trimetazidine during coronary artery graft surgery.
abstract: Reperfusion injury remains the most uncontrolled phenomenon during cardiac surgery. Potential myocardial protection by trimetazidine was tested in a double blind placebo controlled study on 19 patients undergoing aorto-coronary bypass surgery. The trimetazidine group was composed of 10 patients and the placebo group of 9 patients. Pretreatment was started three weeks before surgery with 1 tablet (trimetazidine 20 mg) t.i.d. and the same drug was added to the cardioplegic solutions (trimetazidine: 10(-6) M). The cross clamping time was 41.1 +/- 3.8 minutes in the trimetazidine group and 39.8 +/- 2.3 minutes in the placebo group. Metabolic measurements showed that the increase of malondialdehyde measured in the coronary sinus 20 minutes after reperfusion was significantly (p = 0.014) less in the trimetazidine group (from 1.60 +/- 0.11 to 1.79 +/- 0.2 mumol/L-1) than in the placebo group (from 1.17 +/- 0.11 to 2.84 +/- 0.58 mumol/L-1). Myosin was present 4 hours after surgery in all patients in the placebo group and in 5 of the 10 of the trimetazidine group (p = 0.036). Haemodynamic measurements showed that patients pretreated with trimetazidine had a better ventricular function, as assessed by the stroke work index (SWI) significantly (p = 0.01) higher in the trimetazidine group (0.0391 +/- 0.0029 g/min/m2/beta) than in the placebo group (0.0282 +/- 0.0026 g/min/m2/beat), the evolution of SWI during surgery was not significantly different between the two groups. Thus trimetazidine seems to reduce ischaemia-reperfusion damage during cardiac surgery; moreover pretreatment with trimetazidine allows the patient to face the operation with better ventricular function.
authors.affiliation: Cardiovascular Surgery Department, Hôpital Broussais, Paris, France.
authors.forename: J N
authors.initials: JN
authors.lastname: Fabiani
authors.forename: O
authors.initials: O
authors.lastname: Ponzio
authors.forename: I
authors.initials: I
authors.lastname: Emerit
authors.forename: S
authors.initials: S
authors.lastname: Massonet-Castel
authors.forename: M
authors.initials: M
authors.lastname: Paris
authors.forename: P
authors.initials: P
authors.lastname: Chevalier
authors.forename: V
authors.initials: V
authors.lastname: Jebara
authors.forename: A
authors.initials: A
authors.lastname: Carpentier
mesh_terms: D001804:Blood Transfusion, Autologous; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass / Q000379:methods; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology / Q000601:surgery; D004341:Drug Evaluation; D005260:Female; D006324:Heart Arrest, Induced; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007430:Intraoperative Care; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control; D011300:Preoperative Care; D013997:Time Factors; D014292:Trimetazidine / Q000627:therapeutic use*
chemical_list: D014292:Trimetazidine