[Evaluation of antibody specificity of the monoclonal component in a case of Waldenström's macroglobulinemia].
The antibody specificity of the monoclonal component was studied in a patient with Waldenström's macroglobulinemia who presented with high values of antistreptolysin O (ASO) titer and protein C which are clinical unlikely. Our methods demonstrated that two tests were falsely positive, inasmuch as the antibody activity of the monoclonal component was directed towards the albumin plus latex complex which theoretically is an inert immunological substrate.
Giovanna Zaninetta
M
M
Laboratorio di Analisi Chimico-Cliniche e Microbiologiche, Ospedale S. Martino, Genova.
Moccia
F
F
Paolo Mazzarello
G
G
Mansuino
P
P
Morra
L
L
D000911:Antibodies, Monoclonal / Q000032:analysis*; D000918:Antibody Specificity; D000989:Antistreptolysin / Q000097:blood; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D008875:Middle Aged; D011486:Protein C / Q000032:analysis; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000175:diagnosis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D011486:Protein C; D000989:Antistreptolysin
Valutazione della specificità anticorpale della componente monoclonale in un caso di macroglobulinemia di Waldenström.