title: Central nervous system stimulants as symptomatic treatments for AIDS-related neuropsychiatric impairment.
abstract: Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsychologic testing showed statistically significant improvement in a subset of tests; however, scores did not return to baseline in tests done after the treatment was discontinued for 1-3 days.
authors.affiliation: New York DVA Medical Center, NY 10010.
authors.forename: B
authors.initials: B
authors.lastname: Angrist
authors.forename: M
authors.initials: M
authors.lastname: d'Hollosy
authors.forename: M
authors.initials: M
authors.lastname: Sanfilipo
authors.forename: J
authors.initials: J
authors.lastname: Satriano
authors.forename: G
authors.initials: G
authors.lastname: Diamond
authors.forename: M
authors.initials: M
authors.lastname: Simberkoff
authors.forename: H
authors.initials: H
authors.lastname: Weinreb
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000523:psychology; D000328:Adult; D003913:Dextroamphetamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D008774:Methylphenidate / Q000627:therapeutic use*; D008875:Middle Aged; D009483:Neuropsychological Tests; D016037:Single-Blind Method
chemical_list: D008774:Methylphenidate; D003913:Dextroamphetamine