Association of Wegener's granulomatosis with HLA antigens and other genetic markers.
The frequencies of the HLA-A, B, C, DR, DQ antigens and of several other genetic markers in biopsy proved and well characterised patients with Wegener's granulomatosis were compared with control frequencies of the region. A highly significant increase in HLA-DR1 was found. The percentage combined frequency of DR1-DQw1 was significantly higher in patients than in the controls. Interestingly, association with the red cell enzyme GLOI and complement locus C4B was also seen. As both of these markers are either linked or within the major histocompatibility complex region (MHC) this is further evidence for the involvement of chromosome 6 in the pathogenesis of Wegener's granulomatosis. To understand the pathology of the disease fully molecular genetic studies of the MHC region are warranted.
Papiha
S S
SS
Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom.
Murty
G E
GE
Ad'Hia
A
A
Mains
B T
BT
Venning
M
M
D000328:Adult; D000368:Aged; D002896:Chromosomes, Human, Pair 6; D004198:Disease Susceptibility; D005819:Genetic Markers / Q000235:genetics; D014890:Granulomatosis with Polyangiitis / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000032:analysis; D015798:HLA-DR1 Antigen / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D008875:Middle Aged
D005819:Genetic Markers; D006680:HLA Antigens; D006683:HLA-DQ Antigens; C051568:HLA-DQ1 antigen; D015798:HLA-DR1 Antigen