Mitochondria-lytic action of warfarin in lymphocytes.
Warfarin given as a single dose of 20 mg induces lysis of mitochondria in lymphocytes from chronic and acute lymphocytic leukemias studied under the electron microscope. Normal lymphocytes remain unchanged. This cytotoxic actin may be due to superoxide radicals produced in the malignant cells by warfarin, which is a potent electron-transferring substance.
Berkarda
B
B
Department of Medical Oncology, Cerrahpaşa School of Medicine, Istanbul, Turkey.
Arda
O
O
Tasyurekli
M
M
Derman
U
U
D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology; D008214:Lymphocytes / Q000648:ultrastructure*; D008928:Mitochondria / Q000187:drug effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects*
D014859:Warfarin