LcrF is the temperature-regulated activator of the yadA gene of Yersinia enterocolitica and Yersinia pseudotuberculosis.
The virulence plasmid of human pathogenic Yersinia species, pYV, encodes secreted proteins, Yop proteins, and an outer membrane protein, YadA. YadA has been associated with binding to a variety of substrates and with interference with host defense. YadA is regulated by temperature and is expressed only at 37 degrees C. Unlike the yop regulon, the yadA gene is not under Ca2+ regulation. Here, we show that LcrF (VirF), the temperature-regulated activator of the yop regulon, also acts as an activator for yadA.
Skurnik
M
M
Department of Medical Microbiology, Turku University, Finland.
Toivanen
P
P
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D010957:Plasmids; D016133:Polymerase Chain Reaction; D013696:Temperature; D015008:Yersinia enterocolitica / Q000235:genetics* / Q000472:pathogenicity; D015011:Yersinia pseudotuberculosis / Q000235:genetics* / Q000472:pathogenicity
D001425:Bacterial Outer Membrane Proteins; D009838:Oligodeoxyribonucleotides