title: Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes.
abstract: The phenolic diterpene carnosic acid appears to be the main substance for general oxidation leading to artifacts with gamma- or delta-lactone structure in extracts of Rosmarinus officinalis and Salvia officinalis. Until now it was only possible to prepare carnosic acid by hydrogenolysis of carnosol. A semipreparative HPLC method has been developed isolating carnosic acid among other phenolic diterpenes. The separated substances were identified by 13C-nuclear magnetic resonance (NMR), 1H-NMR, mass and IR spectroscopy. Conversion of carnosic acid and carnosol to other phenolic diterpenes was investigated by HPLC.
authors.affiliation: Institute of Food Science, University of Hannover, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: Schwarz
authors.forename: W
authors.initials: W
authors.lastname: Ternes
mesh_terms: D045784:Abietanes; D000975:Antioxidants / Q000032:analysis* / Q000737:chemistry; D002336:Carnosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010616:Phenanthrenes / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D013055:Spectrophotometry, Infrared
chemical_list: D045784:Abietanes; D000975:Antioxidants; D004224:Diterpenes; D010616:Phenanthrenes; D010936:Plant Extracts; C068623:carnosol; D002336:Carnosine; C018381:salvin