title: Prolonged chemotherapy for localised squamous carcinoma of the oesophagus.
abstract: We evaluated the feasibility of six courses of chemotherapy in 34 consecutive patients with localised squamous cell carcinoma of the oesophagus. All 32 evaluable patients first received at least two courses of chemotherapy. There were 18 patients with resectable carcinomas who underwent surgery and 14 patients with unresectable carcinomas who received definitive chemoradiotherapy. After two courses of 5-fluorouracil and cisplatin 21 (66%) of 32 patients had either a complete or major response. A median of five courses (range, 1-6 courses) was administered. 17 out of 18 (94%) patients with resectable carcinoma had a 'curative' resection (negative proximal, distal, and radial margins by histopathology in an en-block resection specimen) and 2 patients had a complete pathological response. The median survival duration of all patients was 28 months (range, 2-46+ months). The median survival duration of 14 patients with unresectable carcinoma was 23 months (range, 8-36+ months), and the median survival duration of 18 patients with resectable carcinoma has not been reached at a median follow-up of 24+ months (range, 10+ to 46+ months). No deaths occurred because of chemotherapy or chemoradiation therapy. Our data suggest that prolonged chemotherapy is feasible in patients with locoregional squamous carcinoma of the oesophagus. An ongoing controlled trial will determine the contribution of chemotherapy to patients' survival.
authors.affiliation: UT M.D. Anderson Cancer Center, Houston 77030-4096.
authors.forename: J A
authors.initials: JA
authors.lastname: Ajani
authors.forename: B
authors.initials: B
authors.lastname: Ryan
authors.forename: T A
authors.initials: TA
authors.lastname: Rich
authors.forename: M
authors.initials: M
authors.lastname: McMurtrey
authors.forename: J A
authors.initials: JA
authors.lastname: Roth
authors.forename: L
authors.initials: L
authors.lastname: DeCaro
authors.forename: B
authors.initials: B
authors.lastname: Levin
authors.forename: C
authors.initials: C
authors.lastname: Mountain
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D002945:Cisplatin; D005472:Fluorouracil