title: Transcriptional regulation during T-cell development: the alpha TCR gene as a molecular model.
abstract: The regulation of gene expression during lymphocyte differentiation is a complex process involving interactions between multiple positive and negative transcriptional regulatory elements. In this article, transcriptional regulation of the archetypal T-cell-specific gene, alpha TCR, is discussed. Major recent developments, including the identification of novel families of transcription factors that regulate multiple T-cell genes during thymocyte ontogeny and T-cell activation, are described.
authors.affiliation: Howard Hughes Medical Institute, Ann Arbor, MI.
authors.forename: J M
authors.initials: JM
authors.lastname: Leiden
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004742:Enhancer Elements, Genetic; D006801:Humans; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D013601:T-Lymphocytes / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D014157:Transcription Factors; D004247:DNA