title: Large-cell acanthoma is a solar lentigo.
abstract: On the basis of a study of 54 specimens each of large-cell acanthoma, solar lentigo, reticulated seborrheic keratosis, and lichen planus-like keratosis, it is concluded that clinically, histopathologically, and biologically, large-cell acanthoma is a variant of solar lentigo, and solar lentigo (including the large-cell variant) is a stage in the evolution of reticulated seborrheic keratosis and of lichen planus-like keratosis.
authors.affiliation: Dermatopathology Unit, New York University Medical Center, New York.
authors.forename: H J
authors.initials: HJ
authors.lastname: Roewert
authors.forename: A B
authors.initials: AB
authors.lastname: Ackerman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D012628:Dermatitis, Seborrheic / Q000473:pathology; D003937:Diagnosis, Differential; D004817:Epidermis / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000473:pathology; D007642:Keratosis / Q000473:pathology; D007911:Lentigo / Q000209:etiology / Q000473:pathology*; D008010:Lichen Planus / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008543:Melanins / Q000032:analysis; D008544:Melanocytes / Q000473:pathology; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000473:pathology; D010212:Papilloma / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D013472:Sunlight / Q000009:adverse effects
chemical_list: D008543:Melanins