title: Insensitivity of the chick embryo müllerian duct to human recombinant müllerian-inhibiting substance.
abstract: To determine whether mammalian Müllerian-inhibiting substance (MIS) is active in birds, Müllerian ducts from 7- to 8-day-old male or female chick embryos were cultured in the presence of human recombinant MIS at concentrations between 2.5 and 12.5 micrograms/ml. None of 20 ducts regressed at any concentration. In contrast, at concentrations of 2.5-5 micrograms/ml, all 12 Müllerian ducts from 13-day-old male mouse embryos and 13 out of 14 female ducts were inhibited to varying degrees. It is concluded that avian Müllerian ducts are unresponsive to mammalian MIS. There may be a difference in structure between the MIS of birds and mammals, or the signal-transduction system may be different.
authors.affiliation: Laboratorie de Zoologie et d'Embryologie Expérimentale, Université Louis Pasteur, Strasbourg, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Weniger
authors.forename: R L
authors.initials: RL
authors.lastname: Cate
authors.forename: A
authors.initials: A
authors.lastname: Zeis
mesh_terms: D000818:Animals; D054304:Anti-Mullerian Hormone; D002642:Chick Embryo; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009095:Mullerian Ducts / Q000187:drug effects* / Q000254:growth & development; D009924:Organ Culture Techniques; D011994:Recombinant Proteins / Q000494:pharmacology; D013045:Species Specificity; D013735:Testicular Hormones / Q000494:pharmacology*
chemical_list: D006023:Glycoproteins; D006131:Growth Inhibitors; D011994:Recombinant Proteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone