title: Circulating parathyroid hormone and calcitonin in rats after spaceflight.
abstract: Parathyroid hormone and calcitonin, two major calcium-regulating hormones, were measured in the plasma of five experimental groups of rats to evaluate postflight calcium homeostasis after the 14-day COSMOS 2044 flight. Parathyroid hormone values were slightly higher in the flight animals (F) than in the appropriate cage and diet controls (S) (44 +/- 21 vs. 21 +/- 4 pg/ml, P less than 0.05), but they were the same as in the vivarium controls (V), which had different housing and feeding schedules. Neither V nor S showed the increase in plasma creatinine phosphorus and magnesium found in F, features of early renal insufficiency. F showed the lowest mean plasma calcitonin that was statistically different from V only. This difference in F and V (22 +/- 11 vs. 49 +/- 16 pg/ml, P less than 0.05) was most likely due to failure of circulating calcitonin in F to show the normal age-dependent increase we demonstrated in age-matched controls in a separate experiment. Basal values for parathyroid hormone and calcitonin were unchanged after 2 wk of hindlimb suspension, a flight simulation model, in age-matched and younger rats. From a time course experiment serum calcium was higher and parathyroid hormone lower after 4 wk than in ambulatory controls. Postflight circulating levels of parathyroid hormone appear to reflect disturbances in calcium homeostasis from impaired renal function of undetermined cause, whereas levels of calcitonin reflect depression of a normal growth process.
authors.affiliation: National Aeronautics and Space Administration Ames Research Center, Moffett Field, California 94035-1000.
authors.forename: S B
authors.initials: SB
authors.lastname: Arnaud
authors.forename: P
authors.initials: P
authors.lastname: Fung
authors.forename: I A
authors.initials: IA
authors.lastname: Popova
authors.forename: E R
authors.initials: ER
authors.lastname: Morey-Holton
authors.forename: R E
authors.initials: RE
authors.lastname: Grindeland
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology / Q000502:physiology; D000375:Aging / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002116:Calcitonin / Q000097:blood*; D002118:Calcium / Q000097:blood / Q000378:metabolism; D004032:Diet; D006706:Homeostasis / Q000502:physiology; D008297:Male; D009929:Organ Size / Q000502:physiology; D010281:Parathyroid Hormone / Q000097:blood*; D051381:Rats; D013026:Space Flight
chemical_list: D010281:Parathyroid Hormone; D002116:Calcitonin; D002118:Calcium