title: Endothelium-derived hyperpolarizing factor (EDHF).
abstract: In vascular tissues, many types of stimulants which release endothelium-derived relaxing factor (EDRF) hyperpolarized the smooth muscle membrane in an endothelium-dependent manner. The hyperpolarizations were resistant to inhibitors of the actions of EDRF, thereby suggesting that they were elicited by an unidentified substance called endothelium-derived hyperpolarizing factor (EDHF). The EDHF induced hyperpolarization was produced by an increase in K(+)-permeability of the membrane, and was one of the factors to induce endothelium-dependent vasodilations. Release of EDHF required an increase in endothelial Ca2+, due either to release of Ca2+ from intracellular storage or to its influx from the external media.
authors.affiliation: Department of Physiology, Nagoya City University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D004285:Dogs; D004594:Electrophysiology; D004727:Endothelium / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000502:physiology; D011188:Potassium / Q000378:metabolism
chemical_list: D001685:Biological Factors; C067410:endothelium-dependent hyperpolarization factor; D011188:Potassium; D002118:Calcium