title: [Late phase II study of MST-16 (sobuzoxane) efficacy for malignant lymphoma].
abstract: A late phase II study with MST-16 for malignant lymphoma was performed with the collaboration of 11 institutions belonging to the Hanshin Hematological Disease Treatment Research Group. Out of a total 40 patients entered into the study, 37 cases (33 of NHL and 4 HD) were evaluated for efficacy and 27 cases for side effects. The response rate was 29.7% (2 cases of CR and 9 PR). The factors affecting response rate were histological classification, phenotype of tumor cell surface and stage of disease. Bone marrow suppression and G-I disorders were the main toxicities observed, but they disappeared by the cessation of MST-16 treatment.
authors.affiliation: 5th Dept. of Internal Medicine, Center for Adult Diseases, Osaka.
authors.forename: T
authors.initials: T
authors.lastname: Masaoka
authors.forename: T
authors.initials: T
authors.lastname: Kageyama
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
authors.forename: K
authors.initials: K
authors.lastname: Akasaka
authors.forename: T
authors.initials: T
authors.lastname: Yonezawa
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: T
authors.initials: T
authors.lastname: Kitani
authors.forename: K
authors.initials: K
authors.lastname: Yasunaga
authors.forename: A
authors.initials: A
authors.lastname: Horiuchi
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000855:Anorexia / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013280:Stomatitis / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D010879:Piperazines; C057773:sobuzoxane