Interferon alpha-induced changes in Fc gamma R-specific mRNA expression and isotype-specific, Fc gamma R-mediated phagocytosis in C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) macrophages.
Peritoneal exudate macrophages from C3H/OuJ (Lpsn) and C3H/HeJ (Lpsd) mice were treated with interferon alpha (IFN-alpha), and isotype-specific phagocytosis and gene expression were measured. IFN-alpha selectively augments phagocytosis of IgG2a, with a highly significant induction of Fc gamma RI mRNA expression, while parallel Fc gamma RIII alpha measurements show a relatively small increase.
Fultz
M J
MJ
Department of Microbiology, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814.
Vogel
S N
SN
D000818:Animals; D000918:Antibody Specificity; D005260:Female; D007132:Immunoglobulin Isotypes / Q000276:immunology*; D016898:Interferon-alpha / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D010587:Phagocytosis / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis / Q000187:drug effects; D011961:Receptors, Fc / Q000235:genetics* / Q000502:physiology
D007132:Immunoglobulin Isotypes; D016898:Interferon-alpha; D012333:RNA, Messenger; D011961:Receptors, Fc