Effects on plasma lipoproteins and endogenous sex hormones of substituting lean white fish for other animal-protein sources in diets of postmenopausal women.
A crossover 8-wk study was conducted to compare the effects on plasma lipoproteins and endogenous sex hormones of lean white fish (LWF) and of beef, pork, egg, and milk (BPEM) within a prudent diet in postmenopausal women. Diets provided 8050 kJ as 19% proteins, 52% carbohydrates, 29% lipids (P/M/S (proportion of polyunsaturated, monounsaturated, and saturated fatty acids, 1.1:1:1) and approximately 210 mg cholesterol/d. The LWF diet compared with the BPEM diet significantly induced higher concentrations of plasma cholesterol, LDL-apo B, HDL-C, and HDL3-C, indicating that incorporation of LWF as a substitute for BPEM in a low-fat, high-P:S diet offers little benefit with regard to plasma cholesterol and LDL-apoB in postmenopausal women. Moreover, the LWF diet significantly increased plasma SHBG, suggesting that the divergent effects of substituting LWF for other animal-protein sources on plasma cholesterol and lipoproteins may be partly mediated by variations in plasma sex-hormone status.
Jacques
H
H
Département de nutrition humaine et de consommation, Université Laval, Québec, Canada.
Noreau
L
L
Moorjani
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S
D000368:Aged; D000818:Animals; D001055:Apolipoproteins B / Q000097:blood; D002417:Cattle; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage*; D004531:Eggs; D005260:Female; D005399:Fishes; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008460:Meat; D008593:Menopause; D008875:Middle Aged; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013552:Swine
D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D004044:Dietary Proteins; D012739:Gonadal Steroid Hormones; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D012738:Sex Hormone-Binding Globulin; D002784:Cholesterol