[Establishment of a congenic strain with complement regulatory protein of factor H allotype derived from Mus. musculus molossinus].
Factor H is a plasma glycoprotein with M. W of 160 KDa which serves as one of the regulatory proteins for C 3 convertases. We have previously reported three serologically defined mouse factor H allotypes by surveying many laboratory and wild mice. In the present work, we established a congenic strain with factor H allotype, H. 2. on BALB/c (H. 1 allotype) background and named this strain BALB-H.2. Alloantiserum against each allotype has been easily prepared using two congenic strains by immunization with a small amount of whole mouse serum. BALB-H.2 is valuable for the genetic studies on the genes in the vicinity of factor H gene (cfh) derived from Mus. m. molossinus.
Natsuume-Sakai
S
S
Department of Immunobiology, Kanazawa University, Ishikawa, Japan.
Harada
Y
Y
Moriwaki
K
K
D000818:Animals; D003180:Complement C3b Inactivator Proteins / Q000235:genetics* / Q000276:immunology; D017242:Complement Factor H; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains / Q000235:genetics*
D003180:Complement C3b Inactivator Proteins; D017242:Complement Factor H