Effect of a potent PAF antagonist, Y-24180, on an allergen-induced late asthmatic response in guinea-pigs.
The effect of Y-24180, a potent and specific PAF antagonist, on the antigen-induced late asthmatic response in guinea-pigs was investigated. We used an asthmatic guinea-pig model which had a high incidence of dual-phase reaction and high reproducibility. Y-24180 (1 mg/kg, p.o.) had a significant inhibitory effect on the late asthmatic response and eosinophil infiltration in bronchoalveolar lavage fluid. These results suggest that PAF may play, at least partially, an important role in the development of the late asthmatic response. Thus, Y-24180 may be useful for the treatment of asthma.
Inoue
H
H
First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Aratani
H
H
Takishima
T
T
Kagoshima
M
M
Iwahisa
Y
Y
Terasawa
M
M
D000485:Allergens / Q000633:toxicity*; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000188:drug therapy*; D001381:Azepines / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004804:Eosinophils; D006168:Guinea Pigs; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D014230:Triazoles / Q000627:therapeutic use*
D000485:Allergens; D001381:Azepines; D010972:Platelet Activating Factor; D014230:Triazoles; C068035:4-(2-chlorophenyl)-2-(2-(4-isobutylphenyl)ethyl)-6,9-dimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepine