title: Reduced intestinal permeability measured by differently sized polyethylene glycols in acute uremic rats.
abstract: The effect of experimental acute renal failure on the intestinal permeability measured by differently sized polyethylene glycols (PEG) was studied in rats. The permeability was assessed by analysing the 24-hour urinary recovery of PEG molecules (size 326-1,162 D). Acute renal failure was induced by clamping the left renal artery and right-sided nephrectomy. The overall urinary recovery of PEG was decreased in the uremic rats. However, the relative recovery of larger molecules (range 590-1,162 D) was further reduced in the uremic rats. The results which are compared with a computer simulation by a multicompartment model, suggest that the intestinal permeability especially towards larger PEG is decreased in acute uremic rats.
authors.affiliation: Department of Nephrology, University of Linköping, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Magnusson
authors.forename: K E
authors.initials: KE
authors.lastname: Magnusson
authors.forename: T
authors.initials: T
authors.lastname: Sundqvist
authors.forename: T
authors.initials: T
authors.lastname: Denneberg
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D002463:Cell Membrane Permeability; D003198:Computer Simulation; D003401:Creatine / Q000652:urine; D004195:Disease Models, Animal; D007422:Intestines / Q000166:cytology*; D007668:Kidney / Q000502:physiology; D008297:Male; D011092:Polyethylene Glycols / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014511:Uremia / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D011092:Polyethylene Glycols; D003401:Creatine