title: 1,4-Dimethoxy-9(10H)-acridinone derivatives. Synthesis, DNA binding studies and trypanocidal activity.
abstract: New acridinonic derivatives, which are hydroxy- and methoxy-substituted in positions 1, 4, and 1,4 were prepared with a view to obtain antiparasitic drugs. These compounds were tested against Trypanosoma cruzi strains and their capability of interacalation into DNA was determined. Nucleus substitutions, DNA binding, and trypanocidal activities have been correlated.
authors.affiliation: Groupe d'Enseignement et de Recherce en Chimie, Thérapeutique Organique et Physique (GERCTOP), Faculté de Pharmacie, Université de Marseille, France.
authors.forename: H
authors.initials: H
authors.lastname: Berny
authors.forename: N
authors.initials: N
authors.lastname: Bsiri
authors.forename: J J
authors.initials: JJ
authors.lastname: Charbit
authors.forename: A M
authors.initials: AM
authors.lastname: Galy
authors.forename: J C
authors.initials: JC
authors.lastname: Soyfer
authors.forename: J P
authors.initials: JP
authors.lastname: Galy
authors.forename: J
authors.initials: J
authors.lastname: Barbe
authors.forename: D
authors.initials: D
authors.lastname: Sharples
authors.forename: C M
authors.initials: CM
authors.lastname: Mesa Valle
authors.forename: C
authors.initials: C
authors.lastname: Mascaro
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D004247:DNA; D016054:DNA, Protozoan / Q000187:drug effects* / Q000378:metabolism; D007364:Intercalating Agents / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D014344:Trypanocidal Agents / Q000138:chemical synthesis* / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000166:Acridines; D016054:DNA, Protozoan; D007364:Intercalating Agents; D014344:Trypanocidal Agents; D004247:DNA