Interactions of moclobemide with concomitantly administered medication: evidence from pharmacological and clinical studies.
Interactions may occur on pharmacological or pharmacokinetic grounds. Both types of interactions are discussed in relationship with the pharmacological and pharmacokinetic data of moclobemide, a reversible MAO-inhibitor. A variety of interaction studies either designed more specifically as kinetic or as dynamic studies have been performed with moclobemide. The results of these studies are presented. In view of these results as well as in view of data stemming from clinical trials it can be concluded that apart from interactions with cimetidine and pethidine, moclobemide has been shown to be devoid of relevant interactions.
Amrein
R
R
Department of Clinical Research, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Güntert
T W
TW
Dingemanse
J
J
Lorscheid
T
T
Stabl
M
M
Schmid-Burgk
W
W
D000818:Animals; D001549:Benzamides / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D020912:Moclobemide