Abnormal estrogen receptor in clinical breast cancer.
We have discovered a number of estrogen receptor variants in clinical breast cancer tissues. We have base-pair insertions, transitions, and deletions of exons 3, 5 and 7. Using a transactivation assay we have discovered receptors with outlaw function consisting of both dominant-positive receptors which are transcriptionally active in the absence of estrogen, and dominant-negative receptors which are transcriptionally inactive themselves but prevent normal estrogen receptor function.
McGuire
W L
WL
University of Texas Health Science Center, Division of Medical Oncology, San Antonio 78284-7884.
Chamness
G C
GC
Fuqua
S A
SA
D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D010641:Phenotype; D011960:Receptors, Estrogen / Q000235:genetics* / Q000378:metabolism
D011960:Receptors, Estrogen