Role of circulating immune-complexes as prognostic indicators of lympho-reticular and mesenchymal malignancies in children.
Circulating immune complexes (CIC) were estimated in 28 cases of Non-Hodgkin's lymphomas, Hodgkin's disease, bone and soft tissue sarcomas in the pediatric age group by polyethylene glycol (PEG) precipitation and latex agglutination inhibition (LAI) techniques. Results were compared with 25 age-matched controls. Highly significant CIC values were obtained by LAI technique (P less than 0.01) as compared to PEG pptn technique (P less than 0.05) in malignancy. However, seropositivity for CIC in lymphomas and Hodgkin's disease was 85.71 per cent by LAI test as compared to 57.14 per cent by PEG pptn test. In sarcoma group, seropositivity for CIC was 57.11 per cent by LAI test and 28.57 per cent by PEG pptn test. Combination of both these tests increases the sensitivity of immune complex detection in serum of cancer patients. CIC begin to rise in serum in early stages of neoplastic transformation, and the level of CIC is directly proportional to proliferating tumour mass in vivo.
Aziz
M
M
Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
Dass
T K
TK
Rattan
A
A
D000936:Antigen-Antibody Complex / Q000276:immunology*; D002648:Child; D005260:Female; D005455:Fluorescent Antibody Technique; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D011379:Prognosis; D012509:Sarcoma / Q000175:diagnosis* / Q000276:immunology
D000936:Antigen-Antibody Complex