title: NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats.
abstract: Molecular cloning of the subunits of the transcription factor NF-kappa B and its inhibitor l kappa B revealed regions of sequence homology with two different classes of proteins: the Rel/dorsal family and a heterogeneous group of proteins containing ankyrin-like repeats. Both the Rel/dorsal homology domain and the ankyrin-like repeats appear to play important roles in protein-protein interactions that regulate localization and activity of the NF-kappa B subunits.
authors.affiliation: Unité de Biologie Moléculaire du Gène, U. 277 INSERM, Institut Pasteur, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Blank
authors.forename: P
authors.initials: P
authors.lastname: Kourilsky
authors.forename: A
authors.initials: A
authors.lastname: Israël
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017487:Ankyrins; D001798:Blood Proteins / Q000737:chemistry; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000737:chemistry* / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism
chemical_list: D017487:Ankyrins; D001798:Blood Proteins; D008565:Membrane Proteins; D016328:NF-kappa B; D014157:Transcription Factors