Tiron administration minimizes the toxicity of vanadate but not its insulin mimetic properties in diabetic rats.
Although it has been reported that vanadate is effective in diminishing the expression of diabetes in the rat, the severe toxic side effects noted in the vanadate-treated animals suggest that chronic oral administration of vanadate argues against its use in human diabetes. The present study was conducted to evaluate the effects of the chelator Tiron on the mobilization of vanadium after administration of sodium metavanadate in the drinking water (0.20 mg/ml) of streptozotocin-induced diabetic rats for 35 days. Intraperitoneal treatment with Tiron (300 or 600 mg/kg) was initiated after three weeks of vanadate administration and continued for two weeks. The ameliorative effects of vanadium with respect to diabetes were not diminished by the administration of Tiron, but the accumulation of vanadium in kidney and bone was significantly decreased in the Tiron-treated groups and diabetes associated increases in serum GOT, GPT and cholesterol were diminished with Tiron treatment. It is concluded that the coadministration of metavanadate and Tiron may be of potential value for treatment of diabetes mellitus.
Domingo
J L
JL
Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Reus, Spain.
Gomez
M
M
Sanchez
D J
DJ
Llobet
J M
JM
Keen
C L
CL
D014013:1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007328:Insulin / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin; D014638:Vanadates / Q000037:antagonists & inhibitors* / Q000633:toxicity
D001786:Blood Glucose; D007328:Insulin; D014638:Vanadates; D014013:1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; D013311:Streptozocin