[Basic studies of intra-arterial hyperthermic treatment].
Basic studies on intra-arterial hyperthermic treatment (1AHT) were conducted in rabbits implanted with VX2 tumor inside the thigh. For the purpose of determining the best temperature, saline added Adriamycin (ADM) (2 mg/body) that heated up to a predetermined objective temperature was injected. At 3 days after administration, the intratumor concentration of ADM (ITCA) and blood laboratory data were obtained. ITCA of the 53 degrees C group (1.13 +/- 0.41 micrograms/g) was significantly higher than those in the 23 degrees C group. In the 58 degrees C group, BUN, CPK, and creatinine were elevated. These data suggested that the best temperature of IAHT was about 53 degrees C. The treated rabbits were divided into 4 groups (heated saline added ADM, heated saline, non-heated saline added ADM, control) and the tumor growth rates after IAHT were investigated. The tumor size of the groups treated by heated saline was inhibited compared with that in the other two groups. There was no elevation of intratumor temperature in spite of IAHT. At 2 days after the IAHT, patho logically there were vacuolar degeneration in the arterial endothelial cells near the tumor, and narrowing of involved artery. These results suggest that the antitumor effect by IAHT is related with blood supply without hyperthermic effect.
Maeda
T
T
1st Dept. of Surgery, Toho University.
Kuramoto
S
S
Shimojima
Y
Y
Takita
W
W
Ohshiro
M
M
Hanawa
S
S
Watanabe
M
M
Nakazaki
H
H
Yoshio
T
T
Nonaka
H
H
D000818:Animals; D001831:Body Temperature; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006979:Hyperthermia, Induced; D007261:Infusions, Intra-Arterial; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage
D012462:Saline Solution, Hypertonic; D004317:Doxorubicin