title: Proto-oncogene expression in rabbit aorta after wall injury. First marker of the cellular process leading to restenosis after angioplasty?
abstract: In order to study the earliest phenomenons occurring in the arterial wall after balloon angioplasty, the level of expression of the proto-oncogenes, c-fos and c-myc, was studied in rabbit aorta after balloon denudation by using Northern blot analysis. Both c-fos and c-myc are rapidly and transitorily induced (maximal at 30 min and 2 h after mechanical injury for c-fos and c-myc respectively). By comparison, infusion of norepinephrine increases oncogene expression in normal non-denuded rabbit aorta after 1 h, but the combination of both mechanical and hormonal stimuli do not lead to a more important induction than balloon denudation alone.
authors.affiliation: Service de Cardiologie B, Hôpital Cardiologique, Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Bauters
authors.forename: P
authors.initials: P
authors.lastname: de Groote
authors.forename: M
authors.initials: M
authors.lastname: Adamantidis
authors.forename: C
authors.initials: C
authors.lastname: Delcayre
authors.forename: M
authors.initials: M
authors.lastname: Hamon
authors.forename: J M
authors.initials: JM
authors.lastname: Lablanche
authors.forename: M E
authors.initials: ME
authors.lastname: Bertrand
authors.forename: B
authors.initials: B
authors.lastname: Dupuis
authors.forename: B
authors.initials: B
authors.lastname: Swynghedauw
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D001011:Aorta / Q000503:physiopathology; D002455:Cell Division / Q000502:physiology*; D004730:Endothelium, Vascular / Q000293:injuries; D005352:Fibromuscular Dysplasia / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology*; D005819:Genetic Markers / Q000235:genetics; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000293:injuries*; D009638:Norepinephrine / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D012008:Recurrence
chemical_list: D005819:Genetic Markers; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D009638:Norepinephrine