Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells.
Oncostatin M, a cytokine produced by activated lymphoid cells, regulates the growth and differentiation of a number of tumor and normal cells. In contrast to its effects on normal endothelial and aortic smooth muscle cell cultures, Oncostatin M was a potent mitogen for cells derived from acquired immunodeficiency syndrome-related Kaposi's sarcoma (AIDS-KS). After exposure to Oncostatin M, AIDS-KS cells assumed a spindle morphology, had an increased ability to proliferate in soft agar, and secreted increased amounts of interleukin-6. Oncostatin M RNA and immunoreactive Oncostatin M protein were found in AIDS-KS-derived cell isolates. These results suggest that Oncostatin M may play a role in the pathogenesis of AIDS-KS.
Miles
S A
SA
UCLA AIDS Center 90024.
Martínez-Maza
O
O
Rezai
A
A
Magpantay
L
L
Kishimoto
T
T
Nakamura
S
S
Radka
S F
SF
Linsley
P S
PS
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D001483:Base Sequence; D002455:Cell Division / Q000187:drug effects; D006133:Growth Substances / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000096:biosynthesis; D053683:Oncostatin M; D010452:Peptide Biosynthesis; D010455:Peptides / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
D006133:Growth Substances; D009363:Neoplasm Proteins; C508351:OSM protein, human; D010455:Peptides; D011994:Recombinant Proteins; D053683:Oncostatin M