title: [Chronic lead nephropathy. Epidemiology and diagnosis].
abstract: Chronic lead nephropathy has recently been rediscovered. Its usual manifestations are hypertension, gout and renal impairment. Retrospective epidemiological data suggest that prolonged exposure to lead increases the risk of hypertension and nephropathy. An increase in EDTA-induced urinary lead concentration (above 600 micrograms/72 hours), perfectly representative of lead concentration in bone, has been found with a 5 to 12 percent prevalence in chronic renal impairment irrespective of its cause. The origin of lead impregnation and its influence on the course of the renal disease have not yet been elucidated.
authors.affiliation: Service de Néphrologie, CHRU, Brest.
authors.forename: J
authors.initials: J
authors.lastname: Clèdes
authors.forename: P
authors.initials: P
authors.lastname: Allain
mesh_terms: D002908:Chronic Disease; D006073:Gout / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006977:Hypertension, Renal / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D007855:Lead Poisoning / Q000175:diagnosis / Q000453:epidemiology*; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies
vernacular_title: Néphropathie saturnine chronique. Epidémiologie et diagnostic.