title: Effectiveness of dehydroepiandrosterone in reduction of cryptosporidial activity in immunosuppressed rats.
abstract: The aim of this study was to evaluate the efficacy of the immunomodulator dehydroepiandrosterone in the treatment of cryptosporidiosis in glucocorticoid-induced immunosuppressed rats. A significant reduction in cryptosporidial activity occurred in treated versus untreated rats as assessed by oocyst shedding intensities and examination of parasite colonization in the small intestine.
authors.affiliation: Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan 84322-5600.
authors.forename: K R
authors.initials: KR
authors.lastname: Rasmussen
authors.forename: M J
authors.initials: MJ
authors.lastname: Arrowood
authors.forename: M C
authors.initials: MC
authors.lastname: Healey
mesh_terms: D000818:Animals; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000276:immunology; D016785:Cryptosporidium parvum / Q000187:drug effects*; D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D007082:Ileum / Q000469:parasitology / Q000473:pathology; D007165:Immunosuppression Therapy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003687:Dehydroepiandrosterone; D003907:Dexamethasone