Plasma concentrations of atrial peptides ANF(1-98) and ANF(99-126) after intravenous infusion: effect of infusate temperature.
Atrial peptides ANF(1-98) and ANF(99-126) were measured in plasma before and after infusion of Ringer-Acetate solution in healthy volunteers. The solution was infused over a 45 min period in an amount equal to 20 per cent of estimated extra-cellular volume. We found that the increase in atrial peptide immunoreactivity after infusion depended on the temperature of the infusate. The molar increase in ANF(1-98) was much larger than the increase in ANF(99-126). We speculate that plasma levels of ANF(1-98) may be a clinically useful parameter of atrial distension secondary to hypervolaemia.
Hall
C
C
Institute for Surgical Research, Rikshospitalet, University of Oslo, Norway.
Tølløfsrud
S
S
Bjerkelund
C E
CE
Noddeland
H
H
Sundsfjord
J
J
D000328:Adult; D000704:Analysis of Variance; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000009:adverse effects*; D007552:Isotonic Solutions / Q000494:pharmacology; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D013696:Temperature
D007552:Isotonic Solutions; D010446:Peptide Fragments; D011498:Protein Precursors; C028570:Ringer's acetate; C055659:atrial natriuretic factor prohormone (1-98); D009320:Atrial Natriuretic Factor