title: Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease.
abstract: The inflammatory activity in 108 bowel segments of 40 patients with suspected or known inflammatory bowel disease was assessed macroscopically by endoscopy, histology and technetium-99m hexamethyl propylene amine oxine (99mTc-HMPAO) leucocytes using a numerical grading system (scores 0-3). A 4-h series of scintigrams showed a significant correlation with both histological and macroscopical assessment of disease activity (rho = 0.850, P less than 0.001 and rho = 0.773, P less than 0.001, respectively). Sensitivity, specificity and accuracy of scintigraphy in detecting active inflammatory segments were 85%, 92% and 89%, respectively. A normal scintigram did not completely exclude mild inflammatory activity, especially in the rectosigmoid area. 99mTc-HMPAO leucocytes offer an accurate and non-invasive alternative for the assessment of disease activity in ulcerative colitis and Crohn's disease.
authors.affiliation: Department of Radiology, Päijät-Häme Central Hospital, Lahti, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Lantto
authors.forename: K
authors.initials: K
authors.lastname: Järvi
authors.forename: I
authors.initials: I
authors.lastname: Krekelä
authors.forename: T
authors.initials: T
authors.lastname: Lantto
authors.forename: M
authors.initials: M
authors.lastname: Taavitsainen
authors.forename: H
authors.initials: H
authors.lastname: Vedenkangas
authors.forename: M
authors.initials: M
authors.lastname: Vorne
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D003424:Crohn Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000473:pathology; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime