title: Paecilomyces lilacinus infection in a child with chronic granulomatous disease.
abstract: Chronic granulomatous disease (CGD) is a rare inherited disorder in which neutrophils do not appropriately generate cytotoxic superoxide anion, the respiratory burst, in response to invading bacteria or fungi as a part of normal host defence. We report the case of a child with CGD who had two abdominal wall abscesses caused by Paecilomyces lilacinus, an organism not previously known to cause infections in patients with CGD. The abdominal wall is a location that is rarely associated with Paecilomyces infections. Parenteral amphotericin B eradicated the infection in an immunocompromised child whereas this regimen has heretofore largely been unsuccessful in the treatment of this infection. Paecilomyces species and other fungi from immunocompromised hosts and thought to be laboratory contaminants, need to be carefully investigated for they may become pathogens in this clinical setting.
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine, Denver 80262.
authors.forename: C C
authors.initials: CC
authors.lastname: Silliman
authors.forename: D W
authors.initials: DW
authors.lastname: Lawellin
authors.forename: J A
authors.initials: JA
authors.lastname: Lohr
authors.forename: B M
authors.initials: BM
authors.lastname: Rodgers
authors.forename: L G
authors.initials: LG
authors.lastname: Donowitz
mesh_terms: D000009:Abdominal Muscles / Q000382:microbiology*; D000038:Abscess / Q000382:microbiology*; D000666:Amphotericin B / Q000627:therapeutic use; D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D009181:Mycoses / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D010143:Paecilomyces; D012008:Recurrence
chemical_list: D000666:Amphotericin B