title: Racemized D-aspartate in Alzheimer neurofibrillary tangles.
abstract: Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo posttranslational modification by racemization to D-aspartate. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a greater number of these racemized D-aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.
authors.affiliation: Department of Chemistry, University of Miami, Coral Gables, FL 33124.
authors.forename: G H
authors.initials: GH
authors.lastname: Fisher
authors.forename: I L
authors.initials: IL
authors.lastname: Payan
authors.forename: S J
authors.initials: SJ
authors.lastname: Chou
authors.forename: E H
authors.initials: EH
authors.lastname: Man
authors.forename: S
authors.initials: S
authors.lastname: Cerwinski
authors.forename: T
authors.initials: T
authors.lastname: Martin
authors.forename: C
authors.initials: C
authors.lastname: Emory
authors.forename: W H
authors.initials: WH
authors.lastname: Frey
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism*; D052160:Benzothiazoles; D002849:Chromatography, Gas; D005456:Fluorescent Dyes; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D013237:Stereoisomerism; D013844:Thiazoles
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D009419:Nerve Tissue Proteins; D013844:Thiazoles; C009462:thioflavin T; D001224:Aspartic Acid