Oxaflozane overdose in a child.
A case of severe poisoning in a 2 year-old child who ingested 150 mg of oxaflozane, a non-tricyclic antidepressant, is reported. After loss of consciousness, opisthotonos and coma, recovery was obtained with conservative treatment. Atropine-like symptoms were noted. The maximal plasma concentration of oxaflozane was 63 ng/mL. The elimination half-life for N-dealkyloxaflozane was 4.8 h.
Dutertre
J P
JP
Department of Clinical Pharmacology, Centre Hospitalier Régional et Universitaire de Tours, France.
Barbier
P
P
Suc
A L
AL
Jonville
A P
AP
Autret
E
E
D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000506:poisoning*; D002675:Child, Preschool; D003128:Coma / Q000139:chemically induced; D062787:Drug Overdose; D006207:Half-Life; D006801:Humans; D008297:Male; D009025:Morpholines / Q000493:pharmacokinetics / Q000506:poisoning*; D009122:Muscle Hypertonia / Q000139:chemically induced
D000928:Antidepressive Agents; D009025:Morpholines; C005357:oxaflozane