title: [Borrmann 4 gastric cancer treated with l-LV and 5-FU combination--a case report].
abstract: The patient was a 44-year-old female who had Borrmann type 4 gastric cancer with enlarged intra-abdominal lymph node metastasis. L-leucovorin (l-LV, 100 mg/m2/day by intravenous bolus for a period of one minute) and fluorouracil (5-FU, 370 mg/m2/day by intravenous bolus) was administered for 5 consecutive days, with a 28-day interval. Dysphagia was subsided 4 weeks after the initial treatment. After 11 weeks, abdominal lymph node metastasis had been reduced in its size (reduced rate 89%). After 16 weeks, gastric structure were remarkably improved (62.2% enlarged in its focus space) in upper GI X-ray. Therefore, total gastrectomy was performed 20 weeks after the initial combination therapy. She has been alive for the past year after the initial treatment. We concluded a combination therapy of l-LV and 5-FU was effective in this patient.
authors.affiliation: Division of Internal Medicine, Niigata Cancer Center Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
authors.forename: K
authors.initials: K
authors.lastname: Ishizuka
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: A
authors.initials: A
authors.lastname: Nashimoto
authors.forename: K
authors.initials: K
authors.lastname: Ogoshi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D002955:Leucovorin / Q000008:administration & dosage; D008207:Lymphatic Metastasis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D002955:Leucovorin; D005472:Fluorouracil