title: Drug interactions with sufentanil. Hemodynamic effects of premedication and muscle relaxants.
abstract: Induction of anesthesia with synthetic opioids is occasionally accompanied by undesirable hemodynamic changes such as tachycardia and hypertension, or bradycardia and hypotension. We hypothesized that drug interactions cause many of these adverse responses. Therefore, we conducted a randomized double-blind study to investigate the interactive effect of premedication and muscle relaxants on the hemodynamic response to induction with intravenous (iv) sufentanil 10 micrograms.kg-1. Eighty patients with left ventricular ejection fraction greater than or equal to 0.40, undergoing elective coronary artery surgery, were premedicated with either morphine 0.1 mg.kg-1 and scopolamine 6 micrograms.kg-1 intramuscularly, or lorazepam 60 micrograms.kg-1 orally, and paralyzed with either pancuronium 0.1 mg.kg-1 or vecuronium 0.1 mg.kg-1 iv. The four treatment groups were SP (morphine-scopolamine + pancuronium), LP (lorazepam + pancuronium), SV (morphine-scopolamine + vecuronium), and LV (lorazepam + vecuronium). Hemodynamics were recorded at three time periods: 1) control, 2) induction, and 3) intubation. Premedication-relaxant interactions significantly affected hemodynamics. In group SP, mean heart rate (HR) increased significantly on induction (56 +/- 11 to 69 +/- 13 beats.min-1), while mean arterial pressure (MAP) and cardiac index (CI) were unchanged. HR, MAP, and CI were significantly higher after induction in group SP compared to the other three groups. In group LP, mean HR increased less than in group SP (56 +/- 8 to 62 +/- 14 beats.min-1), whereas MAP and CI declined significantly. In group SV, HR and CI were unchanged, but MAP declined significantly. In group LV, HR was stable, whereas both MAP and CI declined significantly. The incidence of pharmacologic interventions during the study period also differed significantly among groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, St. Boniface General Hospital, University of Manitoba, Winnipeg, Canada.
authors.forename: I R
authors.initials: IR
authors.lastname: Thomson
authors.forename: C L
authors.initials: CL
authors.lastname: MacAdams
authors.forename: R J
authors.initials: RJ
authors.lastname: Hudson
authors.forename: M
authors.initials: M
authors.lastname: Rosenbloom
mesh_terms: D000368:Aged; D000771:Anesthesia, Intravenous; D003331:Coronary Vessels / Q000601:surgery; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives*; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents; D011229:Preanesthetic Medication; D017409:Sufentanil
chemical_list: D003473:Neuromuscular Nondepolarizing Agents; D017409:Sufentanil; D005283:Fentanyl