Developmental changes in intestinal glucose transporter mRNA levels.
Developmental changes in glucose transporter mRNA levels in the jejunum of rats of different ages were examined by using slot blot RNA analysis. The level of SGLT1 mRNA did not change significantly through life. The GLUT5 mRNA level was highest in 10-day-old rats and then decreased reaching the adult level by day 20 after birth. The GLUT2 mRNA level was low in rats of 5 and 10 days old, but then increased progressively reaching the adult value by day 25 after birth. These results indicate that the expressions of intestinal facilitative glucose transporter genes change markedly in the third week after birth.
Miyamoto
K
K
Department of Nutrition, School of Medicine, The University of Tokushima, Japan.
Hase
K
K
Taketani
Y
Y
Minami
H
H
Oka
T
T
Nakabou
Y
Y
Hagihira
H
H
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern; D005947:Glucose / Q000378:metabolism*; D007583:Jejunum / Q000737:chemistry; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D009004:Monosaccharide Transport Proteins; D012333:RNA, Messenger; D005947:Glucose