Retrograde distribution of a new 5-aminosalicylic acid enema in patients with ulcerative colitis.
Retrograde colonic distribution of a new 4 g 5-aminosalicylic acid enema (mesalazine) was investigated in seven patients with ulcerative colitis, five of whom were in remission. The enema was labeled with 99m-technetium and imaged by a gamma camera. A median of 86 percent (range 57-90) of the enema had spread beyond the rectum during the first two hours after administration. In four of the five examined patients with left-sided ulcerative colitis, the diseased mucosa was covered within the first 4 hours. In the fifth patient, with involvement of the descending colon, the enema did not spread beyond the very tortuous sigmoid colon 4 or even 8 hours after enema administration.
Almer
S
S
Department of Internal Medicine, Faculty of Health Sciences, Linköping University, Sweden.
Ekberg
S
S
Ström
M
M
D000328:Adult; D000636:Aminosalicylic Acids / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004058:Diffusion; D004733:Enema / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D019804:Mesalamine; D008875:Middle Aged; D011865:Radioisotope Dilution Technique; D011877:Radionuclide Imaging; D013667:Technetium
D000636:Aminosalicylic Acids; D019804:Mesalamine; D013667:Technetium