Crisscross regulation of cell-type-specific gene expression during development in B. subtilis.
Sporulation in Bacillus subtilis is a model for how cells of one type generate other differentiated cell types. During sporulation two cellular compartments arise that differ from each other and from the progenitor cell. Differential gene expression between the two is governed by the successive appearance of four transcription factors whose activities are coordinated in crisscross fashion between the two cells.
Losick
R
R
Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138.
Stragier
P
P
D001412:Bacillus subtilis / Q000254:growth & development* / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D012808:Sigma Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013171:Spores, Bacterial / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology
D012808:Sigma Factor