Central conduction time in progressive supranuclear palsy.
Progressive nuclear palsy (PSP) is a parkinson-like extrapyramidal disorder with pathological evidence of brain stem demyelination. We studied brain stem auditory (BAEP) and somatosensory (SSEP) evoked potentials in 8 patients with progressive supra-nuclear palsy to look for evidence of such central demyelination. We found minor alterations in BAEPs and frequently abnormal SSEPs, suggestive of brain stem white matter involvement in this disorder. Evoked potentials may assist in the differentiation of PSP from other parkinsonian conditions.
Pakalnis
A
A
Department of Neurology, Ohio State University Hospitals, Columbus.
Drake
M E
ME
Huber
S
S
Paulson
G
G
Phillips
B
B
D000368:Aged; D003711:Demyelinating Diseases / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology*