Controlled low protein diets in chronic renal insufficiency: meta-analysis.
OBJECTIVE
To determine whether low protein diets retard the development of end stage renal disease.


METHODS
Meta-analysis of 46 trials since 1975, from which six randomised controlled trials were selected.


METHODS
Five trials in Europe and one in Australia between 1982 and 1991.


METHODS
890 patients with mild to severe chronic renal failure who were followed up for at least one year. 450 patients received a low protein diet and 440 a control diet.


METHODS
Difference in protein intake between control and treated groups of at least 0.2 g protein/kg/day.


METHODS
Number of renal deaths (the necessity to start dialysis or death of patient during study).


RESULTS
156 renal deaths were recorded, 61 in the low protein diet group and 95 in the control group, leading to an odds ratio of low protein to control of 0.54 with a 95% confidence interval of 0.37 to 0.79.


CONCLUSIONS
This result, obtained on a large population of patients suffering from chronic renal insufficiency, strongly supports the effectiveness of low protein diets in delaying the onset of end stage renal disease.
Fouque
D
D
Service de Néphrologie, Hôpital Edouard Herriot, Lyon.
Laville
M
M
Boissel
J P
JP
Chifflet
R
R
Labeeuw
M
M
Zech
P Y
PY
D000293:Adolescent; D000328:Adult; D000368:Aged; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000178:diet therapy* / Q000401:mortality / Q000628:therapy; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D006435:Renal Dialysis
D004044:Dietary Proteins