title: Oxaflozane overdose in a child.
abstract: A case of severe poisoning in a 2 year-old child who ingested 150 mg of oxaflozane, a non-tricyclic antidepressant, is reported. After loss of consciousness, opisthotonos and coma, recovery was obtained with conservative treatment. Atropine-like symptoms were noted. The maximal plasma concentration of oxaflozane was 63 ng/mL. The elimination half-life for N-dealkyloxaflozane was 4.8 h.
authors.affiliation: Department of Clinical Pharmacology, Centre Hospitalier Régional et Universitaire de Tours, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Dutertre
authors.forename: P
authors.initials: P
authors.lastname: Barbier
authors.forename: A L
authors.initials: AL
authors.lastname: Suc
authors.forename: A P
authors.initials: AP
authors.lastname: Jonville
authors.forename: E
authors.initials: E
authors.lastname: Autret
mesh_terms: D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000506:poisoning*; D002675:Child, Preschool; D003128:Coma / Q000139:chemically induced; D062787:Drug Overdose; D006207:Half-Life; D006801:Humans; D008297:Male; D009025:Morpholines / Q000493:pharmacokinetics / Q000506:poisoning*; D009122:Muscle Hypertonia / Q000139:chemically induced
chemical_list: D000928:Antidepressive Agents; D009025:Morpholines; C005357:oxaflozane