title: Oscillations in coupled enzymic reactions at high concentration of enzyme.
abstract: The transient-state kinetic consequences of the coupling of a single-enzyme reaction to other metabolic reactions have been examined in generalized terms. Analytical data are presented which specify under what conditions such coupling may lead to an oscillatory transient rate behaviour of a reaction system involving an enzyme operating by a Michaelian mechanism. The results indicate that the presence of enzyme in concentrations comparable to those of substrate and product may represent a hitherto unforeseen possible source of weakly damped, or even sustained, oscillations in metabolic networks. This observation has some important implications with regard to the occurrence of oscillations in biochemical reaction systems and to transient-state kinetic modelling of metabolic systems.
authors.affiliation: Avdelningen för Biokemi, Kemicentrum, Lunds Universitet, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Ryde-Pettersson
mesh_terms: D004789:Enzyme Activation; D004798:Enzymes / Q000378:metabolism*; D005246:Feedback; D005988:Glyceric Acids / Q000378:metabolism; D007700:Kinetics; D008433:Mathematics; D012273:Ribulose-Bisphosphate Carboxylase / Q000378:metabolism; D012274:Ribulosephosphates / Q000378:metabolism
chemical_list: D004798:Enzymes; D005988:Glyceric Acids; D012274:Ribulosephosphates; C001933:ribulose-1,5 diphosphate; C005156:3-phosphoglycerate; D012273:Ribulose-Bisphosphate Carboxylase