Histological analysis of forelimb regeneration in the California newt Taricha granulosa.
The regenerative ability of the forelimbs of the California rough-skinned newt, Taricha granulosa was determined and compared to the same ability of the adult Mexican axolotl, Ambystoma mexicanum. Forelimbs were amputated distally at the wrist and limbs removed at 1, 2, 3, 4, 5 and 6 weeks post-amputation were examined by histological analysis. Since vitamin A and its derivatives cause extreme changes in pattern formation in the regenerating amphibian limb, we decided to study the ability of retinoic acid to proximalize the distal amputation. Animals injected with RA displayed apparent proximalization of the distal amputation.
Washabaugh
C H
CH
Department of Biology, University of Dayton, OH 45469-2320.
Tsonis
P A
PA
D000557:Ambystoma / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D005552:Forelimb / Q000473:pathology / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects; D012455:Salamandridae / Q000502:physiology*; D013045:Species Specificity; D014212:Tretinoin / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects
D014212:Tretinoin