Rapid induction of glomerular lipidosis in APA hamsters by streptozotocin.
The pathology of male Syrian hamsters of APA strain which were injected intraperitoneally with 40 mg/kg body weight of streptozotocin (SZ) at 2 months of age was examined. It showed long-lasting prominent hyperglycaemia and hyperlipidaemia with glucosuria and the development of glomerular lipidosis from 1 month after SZ-injection (1 MAI). Glomerular lesions were restricted to the juxtamedullary cortex at 1 MAI and then extended to the subcapsular cortex. At 3 MAI, glomerular lesions were characterized by focal segmental glomerulosclerosis showing segmental expansion of the mesangial area due to an increase of basement membrane-like material and mesangial cells with lipid droplets and foam cells. SZ-induced diabetic APA hamsters will be a useful model for the investigation of glomerular lipidosis and focal segmental glomerulosclerosis.
Han
J S
JS
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Sugawara
Y
Y
Doi
K
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006224:Cricetinae; D004195:Disease Models, Animal; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced*; D006943:Hyperglycemia / Q000139:chemically induced; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008064:Lipidoses / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D013311:Streptozocin / Q000633:toxicity*; D013997:Time Factors
D013311:Streptozocin