title: The pre-stenotic Doppler shift signature.
abstract: In two series of measurements the Doppler shift signatures of 10 healthy volunteers were studied at varying distances proximal to a total reflection site, in order to describe parameters which are predictive for downstream lesions. Characteristic changes both in amplitude and time parameters were found; the most marked changes being the abolishment of a DC-component for monophasic signatures, the development or the augmentation of early diastolic reverse flow amplitudes together with a highly significant reduction in the signatures' systolic deceleration time. Maximum changes however tended to be localized at 2 to 4 centimeters upstream from the reflection site. Further upstream propagation was limited. Hence the time course of a Doppler signature and particularly its systolic deceleration should be taken into account in addition to the known resistance indices, if downstream lesions shall be predicted from upstream Doppler signatures. The limited upstream propagation of pre-stenotic Doppler signature changes restricts its diagnostic value to vascular segments where the region adjacent to a lesion is routinely scanned; thus diagnostic benefit can be expected for extracranial carotid artery disease but hardly for peripheral (lower limb) lesions.
authors.affiliation: Department of Clinical Research, Hoechst Wiesbaden.
authors.forename: K H
authors.initials: KH
authors.lastname: Labs
authors.forename: P
authors.initials: P
authors.lastname: Windeck
authors.forename: T
authors.initials: T
authors.lastname: Pischel
authors.forename: K A
authors.initials: KA
authors.lastname: Jäger
mesh_terms: D000328:Adult; D001132:Arm / Q000098:blood supply*; D001783:Blood Flow Velocity / Q000502:physiology; D001916:Brachial Artery / Q000000981:diagnostic imaging; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging*; D008297:Male; D008838:Microcomputers; D012016:Reference Values; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D014463:Ultrasonography / Q000295:instrumentation*