title: [Effect of propionate pathway metabolites on the oxidative activity of liver mitochondria under normal conditions and in vitamin B12 deficiency].
abstract: We performed a comparative investigation in vivo and in vitro of the propionate and methylmalonate effect on oxidative activity of liver mitochondria in control and vitamin B12-deficient rats and found that efficiency of the effects were less pronounced in vitamin B12-deficient rats. It is also shown that the rates of respiration and phosphorylation decreased in liver mitochondria of vitamin B12-deficient rats.
authors.forename: N N
authors.initials: NN
authors.lastname: Gessler
authors.forename: N I
authors.initials: NI
authors.lastname: Fedotcheva
authors.forename: M N
authors.initials: MN
authors.lastname: Kondrashova
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Bykhovskiĭ
mesh_terms: D000818:Animals; D008297:Male; D008764:Methylmalonic Acid / Q000378:metabolism / Q000652:urine; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010172:Palmitoylcarnitine / Q000378:metabolism; D011422:Propionates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D014806:Vitamin B 12 Deficiency / Q000378:metabolism*
chemical_list: D011422:Propionates; D013386:Succinates; D010172:Palmitoylcarnitine; D008764:Methylmalonic Acid; D019802:Succinic Acid; C029658:propionic acid
vernacular_title: Vliianie metabolitov propionatnogo puti na okislitel'nuiu aktivnost' mitokhondriĭ pecheni v norme i pri nedostatochnosti vitamina B12.