Potential of diet therapy on murine AIDS.
Recently, a murine retrovirus (LpBM5 MuLV), which induces immunodeficiency syndrome in mice, termed MAIDS, has been found to have several features similar to those seen in human acquired immunodeficiency syndrome (AIDS). The present study was undertaken to compare the effects of 40% energy restriction (R) and/or ad libitum (AL) diets with vegetable [corn oil, (CO) (n-6)] or marine oil [menhaden fish oil (FO), (n-3)] as a source of dietary fats on the immune function and survival rate of C57BL/6 mice injected with the LpBM5 MuLV virus. Weanling mice were fed, throughout the study, either a 5% CO-, 5% CO(R)-, 20% CO- or 20% FO-based diet and 8 wk later the mice were injected with the LpBM5 MuLV (5 x 10(5) plaque-forming units). The results revealed a significantly prolonged postinjected survival rate in the mice fed 20% FO and 5% CO(R) diets [5% CO = 131 +/- 7 d; 5% CO(R) = 161 +/- 13 d; 20% CO = 125 +/- 6 d; 20% FO = 164 +/- 14 d]. Immunological studies conducted 4 wk after injection revealed decline in both interleukin-2 production and proliferative response to mitogens in spleen cells of mice in all four dietary groups. However, this decline was less apparent in mice fed 5% CO(R) and 20% FO diets.(ABSTRACT TRUNCATED AT 250 WORDS)
Fernandes
G
G
Department of Medicine, Microbiology and Physiology, University of Texas, San Antonio 78284-7874.
Tomar
V
V
Venkatraman
M N
MN
Venkatraman
J T
JT
D000818:Animals; D016718:Arachidonic Acid / Q000032:analysis; D002455:Cell Division; D003208:Concanavalin A / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D015232:Dinoprostone / Q000096:biosynthesis; D002149:Energy Intake; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage; D007376:Interleukin-2 / Q000096:biosynthesis; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000178:diet therapy* / Q000378:metabolism / Q000473:pathology; D013154:Spleen / Q000737:chemistry / Q000473:pathology
D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D007376:Interleukin-2; D003208:Concanavalin A; C033266:Menhaden oil; D016718:Arachidonic Acid; D015232:Dinoprostone