title: Toxicological considerations for protein components of biological pesticide products.
abstract: The toxicity of protein components of microbial pesticide products is evaluated at EPA by requiring that pesticide manufacturers conduct a thorough taxonomic evaluation of the active microbial ingredient. The requirement for acute toxicity testing by dosing laboratory animals with the active microbial ingredient and with fermentation growth medium materials provides additional information on the toxicity of protein components of microbial pesticides. The potential for toxicity from proteins associated with contaminating organisms is addressed by use of appropriate quality control procedures to minimize or prevent growth of contaminants and by screening of fermentation batches for known human/mammalian pathogens. These considerations also would apply to any biochemical pesticide that is formed via the growth of a microorganism. If a protein itself is intended for commercial use as an active pesticide ingredient, acute exposure studies and in vitro digestibility studies could be done to answer potential concerns regarding toxicity.
authors.affiliation: Health Effects Division, U.S. Environmental Protection Agency, Washington, D.C. 20460.
authors.forename: R D
authors.initials: RD
authors.lastname: Sjoblad
authors.forename: J T
authors.initials: JT
authors.lastname: McClintock
authors.forename: R
authors.initials: R
authors.lastname: Engler
mesh_terms: D000818:Animals; D006801:Humans; D010575:Pesticides / Q000633:toxicity*; D011506:Proteins / Q000633:toxicity*
chemical_list: D010575:Pesticides; D011506:Proteins