title: Comparison of pregnancy rates following in vitro fertilization-embryo transfer between the donors and the recipients in a donor oocyte program.
abstract: Our in vitro fertilization (IVF) program provides a unique opportunity to evaluate influences of hormonal milieu on pregnancy outcome, by using a shared pool of oocytes obtained by donors (in exchange for financial assistance). The study presented herein evaluated 38 retrieval cycles (28 oocyte donors/22 recipients). No difference in mean number of embryos transferred was seen (2.7 in the donors vs 2.8 in the recipients). However, a statistically significant difference was seen in the pregnancy rates per retrieval (10.5% donors vs 29% recipients) and per transfer (4/35, 11.1%, vs 11/34, 32.3%). Abortion rates were similar (25% donor, 27.2% recipients). These data suggest that other reports of higher pregnancy rates from donor oocyte programs may not be due exclusively to better-quality oocytes. Possibly a negative effect of hyperstimulation or adverse endometrial environment of the donor (possible chronic endometritis) may explain these data.
authors.affiliation: UMDNJ, Robert Wood Johnson Medical School, Camden.
authors.forename: J H
authors.initials: JH
authors.lastname: Check
authors.forename: K
authors.initials: K
authors.lastname: Nowroozi
authors.forename: J
authors.initials: J
authors.lastname: Chase
authors.forename: A
authors.initials: A
authors.lastname: Nazari
authors.forename: C
authors.initials: C
authors.lastname: Braithwaite
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D001706:Biopsy; D004624:Embryo Transfer; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009865:Oocytes; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D014019:Tissue Donors