title: Switches in cardiac muscle gene expression as a result of pressure and volume overload.
abstract: In the mammalian heart, the expression of genes encoding proteins responsible for contraction, relaxation, and endocrine function changes in hypertrophy resulting from hemodynamic overload. Different mechanisms are involved in this mechanogenic transduction, including 1) differential expression of myosin and actin multigene families, which may account for the decreased velocity of contractile element shortening in hypertrophied heart, 2) nonactivation of the sarcoplasmic reticulum Ca(2+)-ATPase gene, which may explain the increased duration of isometric relaxation, and finally 3) activation in the ventricle of the atrial natriuretic factor gene that is responsible in part for the high plasma levels of this peptide. It is increasingly apparent that these changes are independently regulated, but little is known about the mechanisms underlying this regulation. Preliminary results indicate that it is now possible to analyze the early time course or transcription for each gene after the imposition of hemodynamic overload. This should significantly enhance our understanding of the regulatory mechanisms involved in the phenoconversions of the hemodynamically overloaded heart.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale Unité 127, Hôpital Lariboisière, Paris, France.
authors.forename: K
authors.initials: K
authors.lastname: Schwartz
authors.forename: K R
authors.initials: KR
authors.lastname: Boheler
authors.forename: D
authors.initials: D
authors.lastname: de la Bastie
authors.forename: A M
authors.initials: AM
authors.lastname: Lompre
authors.forename: J J
authors.initials: JJ
authors.lastname: Mercadier
mesh_terms: D000199:Actins / Q000235:genetics*; D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology; D015870:Gene Expression; D005786:Gene Expression Regulation; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D005810:Multigene Family; D009132:Muscles / Q000502:physiology*; D009218:Myosins / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013314:Stress, Mechanical
chemical_list: D000199:Actins; D012333:RNA, Messenger; D009218:Myosins