Molecular cytogenetics in human cancer diagnosis.
This report summarizes the application of fluorescence in situ hybridization for detection and diagnosis of human cancers and for detection of residual cancer cells. This approach allows individual interphase cancer cells to be stained so that aberrations such as aneusomies, translocations, deletions, and gene amplification can be seen in the light microscope. This is accomplished using probes for repeated sequences found at the chromosome centromeres, whole chromosome probes, and/or probes for specific aberrant sequences.
Gray
J W
JW
Department of Laboratory Medicine, University of California, San Francisco 45919.
Pinkel
D
D
D002869:Chromosome Aberrations; D005456:Fluorescent Dyes; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D009693:Nucleic Acid Hybridization
D005456:Fluorescent Dyes