The preparation of [2-deutero-3-fluoro-D-Ala8]cyclosporin A by directed biosynthesis.
Hensens
O D
OD
Merck Sharp & Dohme Research Laboratories, Rahway, N.J. 07065.
White
R F
RF
Goegelman
R T
RT
Inamine
E S
ES
Patchett
A A
AA
D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003524:Cyclosporins / Q000096:biosynthesis* / Q000737:chemistry; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D003904:Mitosporic Fungi / Q000378:metabolism*; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment
D003524:Cyclosporins