Leukemia: stem cells, preleukemia and cure.
Several new or evolving concepts of leukemia biology and treatment are considered including: most leukèmias result from transformation of a stem cell, their phenotype reflecting the site of clonal expansion rather than transformation; most leukemias are preceded by one or more preleukemia phases; and cure may be possible by re-establishing preleukemia or forcing maturation of leukemia cells.
Gale
R P
RP
Department of Medicine, UCLA School of Medicine.
Butturini
A
A
D002471:Cell Transformation, Neoplastic; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D011289:Preleukemia / Q000628:therapy*; D013234:Stem Cells / Q000473:pathology*