[Endothelium contributes to the decreased aortic contractility in response to norepinephrine in experimental septic rats].
The responses to norepinephrine of thoracic aortic rings from septic and sham operated rats were compared. Rings with endothelium taken from septic rats manifested significantly lower maximal contractile response to norepinephrine (575 +/- 46.1 mg) in comparison with sham operated tissues (775 +/- 54.7 mg). Tissues without endothelium showed no significant difference. The results suggest that the diminished responsiveness to norepinephrine of the thoracic aorta in septic rats is mediated, at least in part, by vascular endothelium.
Liu
T
T
Institute of Basic Medical Sciences, Beijing.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000503:physiopathology*
D009638:Norepinephrine