title: Lipocortins (annexins) 1, 2, 4 and 5 are increased in the central nervous system in multiple sclerosis.
abstract: Western blotting and densitometry have been used to investigate the lipocortin content of post-mortem central nervous system (CNS) tissue samples from multiple sclerosis (MS) patients and normal controls. Lipocortins 1, 2, 4 and 5 were all detected in normal control grey and white matter. In white matter samples from MS patients these lipocortins were found to be significantly increased, a further elevation in lipocortin content was observed in MS plaque tissue. The implications of these findings with respect to the role of these proteins in inflammatory CNS disease and a possible mechanism of steroid action in the therapy of MS are discussed.
authors.affiliation: School of Pharmacy and Pharmacology, University of Bath, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Elderfield
authors.forename: J
authors.initials: J
authors.lastname: Newcombe
authors.forename: C
authors.initials: C
authors.lastname: Bolton
authors.forename: R J
authors.initials: RJ
authors.lastname: Flower
mesh_terms: D000328:Adult; D000368:Aged; D017302:Annexins; D015153:Blotting, Western; D002102:Cadaver; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism*; D003720:Densitometry; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism*; D010740:Phospholipases / Q000037:antagonists & inhibitors; D012016:Reference Values; D014018:Tissue Distribution
chemical_list: D017302:Annexins; D002135:Calcium-Binding Proteins; D010740:Phospholipases