Differences in the hypothermic response to ethanol in rats selectively bred for oral ethanol preference and nonpreference.
The duration of retention of tolerance to ethanol was tested in the alcohol-preferring (P) and alcohol-nonpreferring (NP) rats lines, using ethanol-induced hypothermia as a measure of tolerance. Rats received two injections of ethanol (3.5 g/kg) body wt, IP) and the time between the injections was 1, 2, or 3 days. When one day separated the two injections, tolerance to the hypothermic effect of a second "test" injection was found in both lines. When 2 or 3 days separated the two injections, the P line showed a loss of tolerance and the NP line showed sensitization to ethanol. Sensitization in the NP line grew stronger when the interval between injections was increased from 2 to 3 days. The duration of retention of tolerance to ethanol-induced hypothermia in the P line was shorter than has previously been reported for motor impairment in this line. It appears that the duration of tolerance retention in the P line depends on the test used to measure tolerance. Sensitization to ethanol in the NP line may be associated with low oral ethanol intake.
Stewart
R B
RB
Department of Medicine, Indiana University School of Medicine, Indianapolis.
Kurtz
D L
DL
Zweifel
M
M
Li
T K
TK
Froehlich
J C
JC
D000428:Alcohol Drinking / Q000235:genetics / Q000523:psychology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004361:Drug Tolerance; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013045:Species Specificity
D000431:Ethanol