Nucleotide sequence of a cDNA encoding murine fumarylacetoacetate hydrolase.
Hereditary tyrosinemia type I is caused by deficiency of the enzyme fumarylacetoacetate hydrolase (FAH) (EC 3.7.1.2), the final step in tyrosine degradation. We report here the cloning and sequencing of a full length cDNA coding for murine FAH. This cDNA is highly homologous to the previously cloned human and rat genes.
Grompe
M
M
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201.
al-Dhalimy
M
M
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D006801:Humans; D006867:Hydrolases / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats
D004247:DNA; D006867:Hydrolases; C020156:fumarylacetoacetase