title: Comparison of several oximes against poisoning by soman, tabun and GF.
abstract: Three oximes currently being evaluated for adoption as replacement nerve agent therapy by various countries were compared for therapeutic efficacy against the toxic organophosphate inhibitors soman and tabun under a standard set of conditions. These oximes together with PAM-Cl and toxogonin, were also compared for efficacy against GF, an agent weaponized by Iraq. The order of effectiveness against soman was HI-6 greater than HLö-7 greater than pyrimidoxime. HLö-7 was very effective against tabun poisoning while HI-6 and pyrimidoxime were of moderate value. Against GF, HI-6 and HLö-7 were extremely effective, toxogonin was moderately effective, and PAM-Cl and pyrimidoxime were the least effective. HI-6 provided a high level of protection against all of the agents tested as did HLö-7 to a slightly lesser degree. The other oximes suffered from their lack of effects against one or more of the organophosphates.
authors.affiliation: Defence Research Establishment Suffield, Ralston, Alberta, Canada.
authors.forename: P M
authors.initials: PM
authors.lastname: Lundy
authors.forename: A S
authors.initials: AS
authors.lastname: Hansen
authors.forename: B T
authors.initials: BT
authors.lastname: Hand
authors.forename: C A
authors.initials: CA
authors.lastname: Boulet
mesh_terms: D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D010755:Organophosphates / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010091:Oximes / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy; D012999:Soman / Q000633:toxicity*
chemical_list: D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D010755:Organophosphates; D009943:Organophosphorus Compounds; D010091:Oximes; D012999:Soman; C009374:tabun; C053914:cyclohexyl methylphosphonofluoridate