title: Gonadotropin releasing hormone agonist treatment for severe menorrhagia in patients with contraindications to surgery.
abstract: Four patients with heavy menorrhagia, severe iron-deficiency anemia and contraindications to surgery were treated with a gonadotropin-releasing hormone agonist in a depot formulation. At 2 months of therapy they were all amenorrheic, and at 6 months the hematologic values had improved markedly. Gonadotropin-releasing hormone agonists may obviate emergency surgery in patients at high surgical risk or could constitute the first line of sequential therapeutic regimens, once general health conditions have improved.
authors.affiliation: Department of Obstetrics and Gynecology, L. Mangiagalli, University of Milano, School of Medicine, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Vercellini
authors.forename: A
authors.initials: A
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: D'Alberton
authors.forename: T
authors.initials: T
authors.lastname: Motta
authors.forename: R
authors.initials: R
authors.lastname: Maggi
authors.forename: P
authors.initials: P
authors.lastname: Molteni
mesh_terms: D000328:Adult; D002064:Buserelin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000075202:Contraindications; D005260:Female; D017273:Goserelin; D006801:Humans; D007044:Hysterectomy; D008595:Menorrhagia / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged
chemical_list: D017273:Goserelin; D002064:Buserelin