[Functional protein S in 77 patients treated with anticoagulants and in 32 probands with normal coagulation parameters].
We determined functional protein S with a new automated clotting assay, total protein S antigen with the Laurell technique and free protein S antigen with an ELISA test and calculated the ratio of total protein S antigen and prothrombin antigen (Laurell) of plasmas of 77 patients oral anticoagulant therapy and of 32 normals. The correlation of total protein S antigen with protein S activity was found to be r = 0.857. The normal range of the tests was calculated for orally anticoagulated patients and for normals and was compared with the analytical data from 4 orally anticoagulated, congenital protein S deficiency patients. We believe that the automated functional protein S clotting assay is a quick and easily performed test, which now allows even for protein S the use of a functional assay as the first step for the screening of coagulation inhibitor deficiencies.
Halbmayer
W M
WM
Zentrallaboratorium, Krankenhauses der Stadt Wien-Lainz.
Feichtinger
C
C
Rubi
K
K
Fischer
M
M
D001157:Arterial Occlusive Diseases / Q000097:blood / Q000188:drug therapy*; D001798:Blood Proteins / Q000378:metabolism*; D003374:Coumarins / Q000627:therapeutic use*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy*; D017293:Protein S; D011655:Pulmonary Embolism / Q000097:blood / Q000188:drug therapy*; D012016:Reference Values; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy*
D001798:Blood Proteins; D003374:Coumarins; D006023:Glycoproteins; D017293:Protein S
Funktionelles Protein S bei 77 Patienten unter oraler Antikoagulanzientherapie und bei 32 gerinnungsnormalen Personen.