Control of acyl-CoA carboxylase activity in mycobacteria.
Acyl-CoA carboxylase activity in four pathogenic mycobacteria and Mycobacterium smegmatis was shown with both acetyl-CoA and propionyl-CoA substrates. Only very low activity was detected in mycobacteria grown in host tissues or on egg-based media rich in lecithin and avidin. This appeared to be a result of severe depression of activity, as strains which could be grown both in host tissue and egg-based media, and in the relatively simple Dubos or Sauton's media showed 8 to 120-fold higher activity in the simpler media.
Wheeler
P R
PR
Department of Applied Biology, University of Hull, U.K.
Bulmer
K
K
Ratledge
C
C
Dale
J W
JW
Norman
E
E
D000818:Animals; D019735:Carbon-Carbon Ligases; D003470:Culture Media; D008025:Ligases / Q000378:metabolism*; D051379:Mice; D009162:Mycobacterium avium / Q000201:enzymology* / Q000254:growth & development; D013379:Substrate Specificity
D003470:Culture Media; D008025:Ligases; D019735:Carbon-Carbon Ligases; C018757:acyl-CoA carboxylase