The effect of a meniscal prosthesis on knee biomechanics and cartilage. An experimental study in rabbits.
A meniscal prosthesis made of Dacron with polyurethane coating was tested as a substitute for the medial meniscus in a rabbit experimental model concentrating on biomechanical behavior of the knee joint and gross and histologic evaluation 3 months after surgery. The results were compared to sham-operated knees, knees with a peripheral incision of the medial meniscus, and knees with a total meniscectomy. Knees with prosthesis implantation had the same stiffness as knees with sham-operation or meniscal incision, but knees with meniscectomy were stiffer (P less than 0.05). Knees with prosthesis showed lower energy storage during relaxation than knees with sham-operation or meniscal incision (P less than 0.05). Energy storage in the prosthesis group was similar to the meniscectomy group. Partial or total ingrowth of synovial tissue into the prosthesis was present in 93%, and 63% of the incised menisci had healed. Cartilage changes were present in 70% of the prosthesis group, in 25% of the knees with meniscal incision, and in all knees with meniscectomy. The sham-operated knees were free from cartilage degeneration. Knees with prosthesis had the same frequency of cartilage changes on the femur, but had less changes on the tibia compared to knees with meniscectomy. A high rate of osteophyte formation was observed after prosthesis implantation as well as following meniscectomy, but the osteophytes were larger in the prosthesis group (P less than 0.01). The most frequent and severe effect on the synovium was found in the prosthesis group (92%), but no foreign body reaction or loose Dacron particles were found.(ABSTRACT TRUNCATED AT 250 WORDS)
Sommerlath
K
K
Department of Orthopaedic Surgery, University Hospital, Linköping, Sweden.
Gillquist
J
J
D000818:Animals; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology*; D002908:Chronic Disease; D005260:Female; D007719:Knee Joint / Q000473:pathology / Q000502:physiology* / Q000601:surgery; D007720:Knee Prosthesis; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology / Q000502:physiology* / Q000601:surgery; D010003:Osteoarthritis / Q000473:pathology; D011093:Polyethylene Terephthalates; D011817:Rabbits; D013585:Synovitis / Q000473:pathology
D011093:Polyethylene Terephthalates