title: In vivo inhibition of basal and estrogen-induced phospholipase A2 activities by the triphenylethylene antiestrogen, tamoxifen, in immature quail oviduct.
abstract: The effects of tamoxifen on oviductal phospholipase A2 activity were studied in immature quails. Injected alone, from 0.1 to 10 mg/kg tamoxifen significantly reduced basal phospholipase A2 activity 6 h after the injection, independently of the dose used. At 24 h, maximal inhibition (-50%) was observed with 0.1 mg/kg tamoxifen, while higher doses were less effective. Combined with estradiol benzoate, tamoxifen reduced even below the control value (1 mg/kg for 24 h) the increase in phospholipase A2 activity induced by estrogen.
authors.affiliation: INSERM U.352, Laboratoire de Physiologie-Pharmacodynamie, INSA 406, Villeurbanne, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Fayard
authors.forename: S
authors.initials: S
authors.lastname: Chanal
authors.forename: A
authors.initials: A
authors.lastname: Fanidi
authors.forename: J F
authors.initials: JF
authors.lastname: Pageaux
authors.forename: M
authors.initials: M
authors.lastname: Lagarde
authors.forename: C
authors.initials: C
authors.lastname: Laugier
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D010057:Oviducts / Q000187:drug effects / Q000201:enzymology*; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D054467:Phospholipases A2; D011784:Quail; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D013629:Tamoxifen; D004958:Estradiol; D010741:Phospholipases A; D054467:Phospholipases A2