Post-transcriptional regulation of loss of rat striatal D2 dopamine receptor during aging.
The mechanism(s) underlying age-associated diminutions in the rat striatal D2 dopamine receptor (D2-receptor) number was investigated. The levels of D2-receptor mRNA in 4-, 12- and 18-month-old rat striata were found not to change. In contrast, the levels of 110 kDa protein, labeled with a D2-receptor specific antibody, decreased in parallel with [3H]YM-09151-2 binding to striatal membranes. These data suggest a role for post-transcriptional mechanism(s) in age-associated decrease in D2-receptor.
Sakata
M
M
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808.
Farooqui
S M
SM
Prasad
C
C
D000199:Actins / Q000235:genetics; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D001549:Benzamides / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism*; D017448:Receptors, Dopamine D2
D000199:Actins; D001549:Benzamides; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; C030265:nemonapride