title: Quantification of myocardial blood flow and extracellular volumes using a bolus injection of Gd-DTPA: kinetic modeling in canine ischemic disease.
abstract: In order to clarify the relationship between coronary artery disease (including myocardial infarction) and image contrast in gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA)-enhanced MRI it was decided to model the myocardial tissue distribution and clearance of Gd-DTPA using the modified Kety equation. Using a canine model, myocardial tissue Gd-DTPA concentrations ([Gd-DTPA]m) were measured 1 or 5 min after a bolus injection of Gd-DTPA or immediately after the end of a constant infusion of Gd-DTPA in a total of 35 dogs. It was found that within 5 min of a bolus injection [Gd-DTPA]m is determined primarily by myocardial blood flow (MBF) and after about 10 min primarily by myocardial extracellular volumes (MECV). This study suggests that repeat, rapid (every 2-4 s) measurements of myocardial T1 relaxation rates following the bolus injection of Gd-DTPA are required to calculate MBF (i.e., myocardial tissue perfusion) and MECV.
authors.affiliation: Lawson Research Institute, St. Joseph's Health Centre of London, Ontario, Canada.
authors.forename: L D
authors.initials: LD
authors.lastname: Diesbourg
authors.forename: F S
authors.initials: FS
authors.lastname: Prato
authors.forename: G
authors.initials: G
authors.lastname: Wisenberg
authors.forename: D J
authors.initials: DJ
authors.lastname: Drost
authors.forename: T P
authors.initials: TP
authors.lastname: Marshall
authors.forename: S E
authors.initials: SE
authors.lastname: Carroll
authors.forename: B
authors.initials: B
authors.lastname: O'Neill
mesh_terms: D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000175:diagnosis*; D004285:Dogs; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008297:Male; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA