title: Primary myeloblastoma of the pineal region.
abstract: The first case of a pinealis region tumor of the hematopoietic system without known leukemia (so-called primary myeloblastoma, primary granulocytic sarcoma) is reported. Two weeks after resection, the 3.5-year-old patient suffered from a local recurrence. At this time, a bone marrow infiltration by leukemic blasts was diagnosed for the first time. An aggressive chemotherapy and radiation induced a complete remission, over a 26-month follow-up period. We examined the removed tumor tissue by routine histology methods, immuno- and enzyme histochemistry and electron microscopy. The CSF was studied by conventional microscopy and enzyme cytochemistry. We discuss the epidemiological data of nine previously published cases of primary intracranial myeloblastoma.
authors.affiliation: Institut für Pathologie, Universität zu Köln, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Voessing
authors.forename: F
authors.initials: F
authors.lastname: Berthold
authors.forename: K E
authors.initials: KE
authors.lastname: Richard
authors.forename: F
authors.initials: F
authors.lastname: Thun
authors.forename: R
authors.initials: R
authors.lastname: Schroeder
authors.forename: G R
authors.initials: GR
authors.lastname: Krueger
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D005500:Follow-Up Studies; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology* / Q000601:surgery; D008297:Male; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D010870:Pineal Gland / Q000473:pathology* / Q000601:surgery