title: Failure of buserelin-induced medical castration to control pulmonary lymphangiomyomatosis in two patients.
abstract: Two women, aged 44 and 29 years, respectively, were admitted to the hospital in early 1987 for recurrent pneumothorax, dyspnea and a diffuse reticulonodular pattern evidenced on the chest x-ray film. Lung biopsy confirmed LAM in both patients. Both were treated sequentially with medroxyprogesterone and a LHRH agonist (buserelin) to achieve reversible medical castration. Neither subjective nor objective improvement was noted after 13 and 5 months, respectively, of buserelin therapy (900 micrograms/day, nasal spray) despite an effective suppression of the pituitary-gonadal axis. Medroxyprogesterone also was ineffective. Buserelin thus failed to control pulmonary LAM in these two patients, in spite of effective medical castration.
authors.affiliation: Department of Respiratory Medicine, CHU, University of Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Radermecker
authors.forename: R
authors.initials: R
authors.lastname: Broux
authors.forename: J L
authors.initials: JL
authors.lastname: Corhay
authors.forename: R
authors.initials: R
authors.lastname: Limet
authors.forename: M
authors.initials: M
authors.lastname: Radermecker
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002064:Buserelin / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008203:Lymphangiomyoma / Q000150:complications / Q000188:drug therapy*; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives; D017258:Medroxyprogesterone Acetate; D010053:Ovary / Q000187:drug effects*; D011030:Pneumothorax / Q000209:etiology; D012008:Recurrence; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D013629:Tamoxifen; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone; D002064:Buserelin