title: Effect of dehydration on the disposition kinetics of erythromycin in rabbits.
abstract: The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water-deprived population.
authors.affiliation: Department of Pharmacology, Aga Khan University Medical College Karachi, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
authors.forename: S K
authors.initials: SK
authors.lastname: Niazi
authors.forename: T
authors.initials: T
authors.lastname: Ahmad
authors.forename: N A
authors.initials: NA
authors.lastname: Muzaffar
authors.forename: M
authors.initials: M
authors.lastname: Nawaz
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D003681:Dehydration / Q000378:metabolism*; D004917:Erythromycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008055:Lipids / Q000097:blood; D008297:Male; D011817:Rabbits
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D008055:Lipids; D004917:Erythromycin