Recognition and prevention of two cases of erroneous haemocytometry counts due to platelet and white blood cell aggregation. The use of acid citrate dextrose as an auxiliary anticoagulant.
Two cases of anticoagulant-induced platelet-white blood cell aggregation are described, which resulted in erroneous haemocytometry counts. Aggregation was avoided by the use of acid citrate dextrose (ACD) as an auxiliary anticoagulant, thus enabling quantification of platelets and white blood cells.
Lombarts
A J
AJ
Department of Clinical Chemistry and Haematology, Leyenburg Hospital, The Hague, The Netherlands.
de Kieviet
W
W
Franck
P F
PF
Baars
J D
JD
D000925:Anticoagulants / Q000494:pharmacology*; D001772:Blood Cell Count / Q000187:drug effects*; D002449:Cell Aggregation / Q000187:drug effects*; D019343:Citric Acid; D004492:Edetic Acid / Q000494:pharmacology; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010976:Platelet Count / Q000187:drug effects
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; C002113:acid citrate dextrose; D019343:Citric Acid; D004492:Edetic Acid; D005947:Glucose