[Brain aging and calcium antagonist drugs. A preliminary open study with nimodipine].
Forty patients aged 65-80 with minor-medium signs of brain aging were treated for 6 months with daily 90 mg doses of nimodipine. Treatment was well tolerated in that the minor side effects reported by a few of the patients never required withdrawal of the drug. Treatment proved useful, as shown by a variety of mental tests, in 69.5% of cases. In 20% conditions remained unchanged and in 9.5% further deterioration was observed. The authors conclude that nimodipine may be considered a useful therapeutic resource for phenomena of brain aging.
Centonze
V
V
Istituto di Clinica Medica I, Università degli Studi di Bari.
Massaro
C
C
Polito
B M
BM
Cassiano
M A
MA
Di Bari
M
M
Russo
P
P
Cirillo
L
L
Albano
O
O
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D003704:Dementia / Q000188:drug therapy / Q000523:psychology; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D009553:Nimodipine / Q000009:adverse effects / Q000627:therapeutic use*; D011581:Psychological Tests; D013997:Time Factors
D009553:Nimodipine
Invecchiamento cerebrale e farmaci calcio-antagonisti. Studio preliminare in aperto con la nimodipina.