Relation of short-term pyridoxine-HCl supplementation to plasma vitamin B-6 vitamers and amino acid concentrations in young women.
Pyridoxal 5'-phosphate (PLP) is a coenzyme in many metabolic transformations of amino acids and may play a role in their absorption and transport. This investigation analyzed the effects of large oral doses (27 mg/d) of pyridoxine (PN)-HCl over 2 wk on plasma PLP and amino acid concentrations in 10 young women. Plasma PLP was 45 +/- 2 nmol/L (means +/- SE) initially and reached 377 +/- 12 nmol/L after 7 d of supplementation. A steady-state PLP concentration remained as long as daily PN-HCl supplementation was continued. Plasma glutamic acid concentration was significantly lower after 7 and 14 d of supplementation whereas alpha-amino-N-butyric acid, alanine, cysteine, arginine, phosphoserine, and urea concentrations were significantly higher, particularly alpha-amino-N-butyric acid and cysteine. Altered plasma amino acid profiles and increased plasma urea concentrations in response to supplementation suggested accelerated protein and/or amino acid metabolism.
Kang-Yoon
S A
SA
Department of Foods and Nutrition, Purdue University, West Lafayette, IN.
Kirksey
A
A
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D004032:Diet; D005260:Female; D006801:Humans; D011732:Pyridoxal Phosphate / Q000097:blood; D011736:Pyridoxine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D014508:Urea / Q000097:blood
D000596:Amino Acids; D011732:Pyridoxal Phosphate; D014508:Urea; D011736:Pyridoxine