Autoantibodies to CD45 in systemic lupus erythematosus.
Autoantibodies to surface antigens on lymphocytes and other cells of the immune system may contribute to the development of immunoregulatory and other cellular immune abnormalities in patients with active systemic lupus erythematosus. Of special interest in this respect are autoantibodies to CD45 (leukocyte-common antigen, T200), a plasma membrane protein tyrosine phosphatase implicated in the regulation of lymphocyte functional activity, including cytotoxicity, proliferation, and differentiation.
Winfield
J B
JB
Division of Rheumatology and Immunology, University of North Carolina, Chapel Hill 27599.
Mimura
T
T
Fernsten
P D
PD
D000918:Antibody Specificity; D015703:Antigens, CD / Q000276:immunology* / Q000502:physiology; D000961:Antilymphocyte Serum; D001323:Autoantibodies / Q000032:analysis / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D004789:Enzyme Activation; D006649:Histocompatibility Antigens / Q000276:immunology* / Q000502:physiology; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D017493:Leukocyte Common Antigens; D007962:Leukocytes / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism
D015703:Antigens, CD; D000961:Antilymphocyte Serum; D001323:Autoantibodies; D006649:Histocompatibility Antigens; D007075:Immunoglobulin M; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D017493:Leukocyte Common Antigens