Malignant hyperthermia. An historical vignette.
This paper reports previously unpublished accounts of the deaths in 1915 and 1919 of two members of the same family during general anaesthesia. The deaths were subsequently ascribed to a 'hereditary susceptibility' to chloroform. Contemporary evidence is presented which suggests that these deaths were among the very earliest examples of malignant hyperthermia to be described.
Harrison
G G
GG
Department of Anaesthesia, University of Cape Town Medical School & Groote Schuur Hospital, Observatory, South Africa.
Isaacs
H
H
D002675:Child, Preschool; D002725:Chloroform / Q000009:adverse effects; D004198:Disease Susceptibility; D005260:Female; D049673:History, 20th Century; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000235:genetics / Q000266:history* / Q000401:mortality; D010375:Pedigree
D002725:Chloroform