title: Protein depletion and metabolic stress in elderly patients who have a fracture of the hip.
abstract: A prospective study was performed to determine the effect of protein depletion and postoperative nutritional status on the outcome in sixty-three elderly patients who had been admitted to the hospital because of a fracture of the hip. The parameters that were used to determine the degree of protein depletion included levels of albumin, of prealbumin, and of transferrin; total lymphocyte count; and nitrogen-balance studies. The outcomes that were examined were the development of complications, the length of the stay in the hospital, the ability to return to the pre-fracture level of function, and over-all survivorship. The hypothesis was that the acute fracture and the subsequent operation are severe stresses in these elderly, often compromised patients. The results supported the hypothesis. Thirty-seven patients (58 per cent) in the study group were in a protein-depleted state during the period of hospitalization. The patients who were protein-depleted had a higher prevalence of complications, were less likely to return to their pre-fracture environment, and tended to stay in the hospital longer, as compared with the nonprotein-depleted patients. Survivorship analysis showed that protein-depleted patients had a significantly lower probability of survival one year after the fracture of the hip (p = 0.02). Elderly patients who sustain the trauma of a fracture of the hip should be managed appropriately with regard to intake of nutrients in the postoperative period.
authors.affiliation: Cornell University Medical Center, Hospital for Special Surgery-New York Hospital Fracture Service, N.Y. 10021.
authors.forename: B M
authors.initials: BM
authors.lastname: Patterson
authors.forename: C N
authors.initials: CN
authors.lastname: Cornell
authors.forename: B
authors.initials: B
authors.lastname: Carbone
authors.forename: B
authors.initials: B
authors.lastname: Levine
authors.forename: D
authors.initials: D
authors.lastname: Chapman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006620:Hip Fractures / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D009752:Nutritional Status; D011183:Postoperative Complications / Q000628:therapy; D011228:Prealbumin / Q000032:analysis; D011446:Prospective Studies; D011488:Protein Deficiency / Q000097:blood / Q000150:complications* / Q000628:therapy; D012709:Serum Albumin / Q000032:analysis; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism; D014168:Transferrin / Q000032:analysis
chemical_list: D011228:Prealbumin; D012709:Serum Albumin; D014168:Transferrin; D009584:Nitrogen