Expiratory muscle activity in the awake and sleeping human during lung inflation and hypercapnia.
Expiratory muscle activity has been shown to occur in awake humans during lung inflation; however, whether this activity is dependent on consciousness is unclear. Therefore we measured abdominal muscle electromyograms (intramuscular electrodes) in 13 subjects studied in the supine position during wakefulness and non-rapid-eye-movement sleep. Lung inflation was produced by nasal continuous positive airway pressure (CPAP). CPAP at 10-15 cmH2O produced phasic expiratory activity in two subjects during wakefulness but produced no activity in any subject during sleep. During sleep, CPAP to 15 cmH2O increased lung volume by 1,260 +/- 215 (SE) ml, but there was no change in minute ventilation. The ventilatory threshold at which phasic abdominal muscle activity was first recorded during hypercapnia was 10.3 +/- 1.1 l/min while awake and 13.8 +/- 1 l/min while asleep (P less than 0.05). Higher lung volumes reduced the threshold for abdominal muscle recruitment during hypercapnia. We conclude that lung inflation alone over the range that we studied does not alter ventilation or produce recruitment of the abdominal muscles in sleeping humans. The internal oblique and transversus abdominis are activated at a lower ventilatory threshold during hypercapnia, and this activation is influenced by state and lung volume.
Wakai
Y
Y
Department of Medicine, University of British Columbia, Vancouver, Canada.
Welsh
M M
MM
Leevers
A M
AM
Road
J D
JD
D000009:Abdominal Muscles / Q000502:physiology; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D011175:Positive-Pressure Respiration; D015656:Respiratory Mechanics / Q000502:physiology*; D012132:Respiratory Muscles / Q000502:physiology*; D012890:Sleep; D014851:Wakefulness