Effect of antisperm antibodies on postcoital results and effect of intrauterine insemination on pregnancy outcome.
The effect of antisperm antibodies (ASA) in males was determined in 59 men using the direct immunobead test (IBT). Postcoital tests were evaluated in couples for whom all female factors appeared to be corrected. Pregnancy rates in 6 months were compared in couples with good postcoital tests vs. those with poor results; the latter group was treated with timed intrauterine insemination (IUI). Thirty-one percent of males with positive ASA (greater than or equal to 50%) had normal postcoital tests and all four achieved pregnancies. Fifty-six percent of men with positive ASA and poor postcoital scores achieved pregnancies following IUI therapy of their wives in 6 months; 83% of couples with normal postcoital tests achieved pregnancies as did couples treated with IUI when the postcoital was poor but the male ASA negative.
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J H
JH
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Cooper Hospital/University Medical Center, Camden.
Bollendorf
A
A
D000906:Antibodies / Q000032:analysis*; D003075:Coitus; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000276:immunology*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D013073:Sperm Agglutination / Q000502:physiology*; D013094:Spermatozoa / Q000276:immunology*
D000906:Antibodies