Perioperative neutron brachytherapy with californium-252.
Between 1973 and 1988, 495 patients were treated with Cf-252 neutron brachytherapy. Cf-252 neutron therapy sources developed in the USSR has been used in the trial. A numerical reconstruction method for localization of Cf-252 cell coordinates by projections on orthogonal radiographs has been designed and used for treatment planning. Eight (1.6%) patients with recurrent and persistent head and neck tumors and ages from 32 to 48 years (mean age 43 years) were treated with Cf-252 perioperative neutron brachytherapy. There were three patients with oral cavity, one with oropharynx, three with parotid gland cancers, and one with a skin tumor. The dose rate ranged fro 3.2 cGy/h to 11.1 cG/h, the minimal peripheral dose ranged from 3 Gy to 8 Gy. Initial local control was achieved in all patients. Local recurrence developed in two cases. Three patients died in first year after therapy. Three patients died during the second year. Two patients are long term cures, one patient more than nine years and one eight years, that is 25% of the treated patients.
Vtyurin
B M
BM
Brachytherapy Dept., Institute of Medical Radiology RAMS, Obninsk, Kaluga Region, Russia.
Medvedev
V S
VS
Ivanov
V N
VN
Anikin
V A
VA
Ivanova
L F
LF
D000328:Adult; D001918:Brachytherapy; D002142:Californium; D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000532:radiotherapy / Q000601:surgery*; D009502:Neutrons; D012189:Retrospective Studies; D012426:Russia / Q000453:epidemiology
D002142:Californium