[Effect of Tremella polysaccharide on IL-2 production by mouse splenocytes].
Tremella polysaccharide (TP) is an important component isolated from Tremella fuciformis Berk. In this study, the in vitro effect of TP on IL-2 production was examined in activated mouse splenocytes. TP (1, 5, 10 and 50 micrograms/ml) significantly increased mouse splenocyte IIL-2 production. In aged mice, the level of IL-2 production is much lower than that in young controls. TP (0.05, 0.5 and 5 micrograms/ml) restored the IL-2 production to normal level as the young control. Furthermore, TP (0.05, 0.5 and 5 micrograms/ml) was found to partly antagonize the suppressive effect of hydrocortisone on IL-2 production. The antagonistic effect of TP (5 micrograms/ml) on the inhibitory activity of cyclosporin A was also observed.
Ma
L
L
Department of Pharmacology, Beijing Medical University.
Lin
Z B
ZB
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry; D016572:Cyclosporine / Q000037:antagonists & inhibitors; D005260:Female; D006854:Hydrocortisone / Q000037:antagonists & inhibitors; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000378:metabolism
D007376:Interleukin-2; D011134:Polysaccharides; D016572:Cyclosporine; D006854:Hydrocortisone