Peritoneal ultrafiltration after chronic exposure to dialysis fluid.
Eleven rats were given twice-daily intraperitoneal injections of 20 mL of dialysis fluid containing 4.5% glucose for 6 weeks. The peritoneal ultrafiltration capacity of this group was compared with that of a control group of 10 rats that had received no injections by measuring the volume and glucose concentration of the dialysate remaining in the peritoneal cavity 2 hours after injection. Animals that had received injections of dialysis fluid showed significant loss of peritoneal ultrafiltration: volume of dialysate remaining in the control group was 31 (13-35) mL, and in the experimental group was 25 (11-45) mL, with p less than 0.02 (Mann-Whitney). This was associated with enhanced glucose absorption: glucose absorbed by the control group was 382 (312-706) mg, and 595 (435-738) mg in the experimental group (p less than 0.002, Mann-Whitney).
Slater
N D
ND
Renal and Transplant Unit, Northern General Hospital, Sheffield, U.K.
Cope
G H
GH
Raftery
A T
AT
D000818:Animals; D015314:Dialysis Solutions / Q000494:pharmacology*; D005947:Glucose / Q000493:pharmacokinetics*; D008297:Male; D010537:Peritoneum / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014462:Ultrafiltration
D015314:Dialysis Solutions; D005947:Glucose