title: The nature of an accessory cell in bone marrow stimulating murine megakaryocytopoiesis.
abstract: The nature of accessory cells in unstimulated mouse bone marrow that modulates in vitro megakaryocytopoiesis by releasing megakaryocyte potentiator (Mk-potentiator) activity was investigated. An active cell class was identified by the 7/4 and Ia cellular antigens. Bone marrow macrophages were obtained by their defined outgrowth in the presence of growth factors. Bone marrow macrophages grown in the presence of interleukin 3 (IL-3) were more active in producing Mk-potentiator than were macrophages grown in the presence of colony-stimulating factor 1 (CSF-1). The data indicate that the accessory cells producing Mk-potentiator are a select population of bone marrow macrophages that may be responsible for inducing megakaryocyte maturation under steady-state conditions.
authors.affiliation: Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Jackson
authors.forename: N
authors.initials: N
authors.lastname: Williams
authors.forename: N
authors.initials: N
authors.lastname: Banu
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000502:physiology*; D001853:Bone Marrow / Q000378:metabolism / Q000502:physiology; D001854:Bone Marrow Cells; D002455:Cell Division / Q000502:physiology; D003115:Colony-Stimulating Factors / Q000494:pharmacology; D058851:GPI-Linked Proteins; D006410:Hematopoiesis / Q000502:physiology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007377:Interleukin-3 / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008533:Megakaryocytes / Q000166:cytology* / Q000502:physiology; D008562:Membrane Glycoproteins; D000090204:Mesothelin; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: D003115:Colony-Stimulating Factors; D058851:GPI-Linked Proteins; D000949:Histocompatibility Antigens Class II; D007377:Interleukin-3; D008562:Membrane Glycoproteins; D011506:Proteins; D000090204:Mesothelin