Mitochondrial disorders in pediatrics. Clinical, biochemical, and genetic implications.
Disorders secondary to mitochondrial dysfunction are likely to be common in the population. The clinical aspects of these disorders are varied and may follow nonclassic inheritance patterns. These disorders serve to illustrate the importance of the clinical history and family history in directing diagnostic approaches.
Clarke
L A
LA
Department of Medical Genetics, University Hospital, Vancouver, British Columbia, Canada.
D002648:Child; D004247:DNA / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics; D006801:Humans; D008661:Metabolism, Inborn Errors / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D008928:Mitochondria / Q000378:metabolism*; D009154:Mutation; D010375:Pedigree
D004272:DNA, Mitochondrial; D004247:DNA