[Effect of propionate pathway metabolites on the oxidative activity of liver mitochondria under normal conditions and in vitamin B12 deficiency].
We performed a comparative investigation in vivo and in vitro of the propionate and methylmalonate effect on oxidative activity of liver mitochondria in control and vitamin B12-deficient rats and found that efficiency of the effects were less pronounced in vitamin B12-deficient rats. It is also shown that the rates of respiration and phosphorylation decreased in liver mitochondria of vitamin B12-deficient rats.
Gessler
N N
NN
Fedotcheva
N I
NI
Kondrashova
M N
MN
Bykhovskiĭ
V Ia
VIa
D000818:Animals; D008297:Male; D008764:Methylmalonic Acid / Q000378:metabolism / Q000652:urine; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010172:Palmitoylcarnitine / Q000378:metabolism; D011422:Propionates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000378:metabolism; D019802:Succinic Acid; D014806:Vitamin B 12 Deficiency / Q000378:metabolism*
D011422:Propionates; D013386:Succinates; D010172:Palmitoylcarnitine; D008764:Methylmalonic Acid; D019802:Succinic Acid; C029658:propionic acid
Vliianie metabolitov propionatnogo puti na okislitel'nuiu aktivnost' mitokhondriĭ pecheni v norme i pri nedostatochnosti vitamina B12.