title: Early pregnancy factor (EPF) as a marker for the diagnosis of subclinical embryonic loss.
abstract: The validation of EPF as a possible correlate of early fertilization has made it possible to study and detect fertilization of the ovum in normal fertile women (during the luteal phase) and also in women with infertility, where the fertilization of the ovum may not be affected but there may be impairment in early embryonic development which results in early embryo loss or subclinical embryo loss. Our results have suggested that using EPF as a marker, we could detect subclinical embryonic loss in 57.8% of the infertile women where more than one menstrual cycle was studied and the blood was collected 4-7 days after ovulation. After the missed period, 80% of the patients who were negative for EPF but positive for hCG had spontaneous abortions. It would be interesting to study how EPF behaves as a marker, to detect subclinical embryonic loss in diverse pathological situations such as recurrent abortions, parental age and translocation carrier parents.
authors.affiliation: Institute for Research in Reproduction, Parel, Bombay, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Shahani
authors.forename: C
authors.initials: C
authors.lastname: Moniz
authors.forename: S
authors.initials: S
authors.lastname: Chitlange
authors.forename: P
authors.initials: P
authors.lastname: Meherji
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D018835:Chaperonin 10; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood*; D007247:Infertility, Female / Q000097:blood / Q000276:immunology*; D010060:Ovulation; D010062:Ovulation Induction; D010455:Peptides / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins; D016037:Single-Blind Method; D013491:Suppressor Factors, Immunologic
chemical_list: D015415:Biomarkers; D018835:Chaperonin 10; D007166:Immunosuppressive Agents; D010455:Peptides; D011257:Pregnancy Proteins; D013491:Suppressor Factors, Immunologic; C025124:early pregnancy factor