Comparison of one-day oral dosing with three bismuth compounds for the suppression of Helicobacter pylori assessed by the 13C-urea breath test.
Assessment of intragastric urease activity by the 13C-urea breath test was performed before and after one day of dosing with either De-Noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), Pepto-Bismol liquid (bismuth salicylate 30 ml q.d.s.), or Roter tablets (bismuth subnitrate, one tablet q.d.s.) in twelve Helicobacter pylori-positive patient volunteers. There was a significant decrease in the excess of 13CO2 after one day of dosing with each of the three bismuth compounds, but analysis of variance could detect no difference between the effects of the three compounds. Systemic absorption of bismuth following oral dosing with either Pepto-Bismol or Roter is minimal, yet both compounds have a suppressive effect on H. pylori similar to that of De-Noltab. This study suggests that the action of all three bismuth compounds is within the gastric lumen, and that systemic absorption of bismuth is not necessary for activity against H. pylori.
Prewett
E J
EJ
University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Luk
Y W
YW
Fraser
A G
AG
Lam
W M
WM
Pounder
R E
RE
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001729:Bismuth / Q000008:administration & dosage / Q000494:pharmacology*; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D012459:Salicylates / Q000008:administration & dosage / Q000494:pharmacology*; D014508:Urea; D014510:Urease / Q000378:metabolism
D009942:Organometallic Compounds; D012459:Salicylates; D002245:Carbon Dioxide; C015715:bismuth subsalicylate; D014508:Urea; D014510:Urease; C010804:bismuth subnitrate; D001729:Bismuth