title: Immunoglobulin E distribution in atopic nasal mucosa.
abstract: The distribution of B lymphocytes and immunoglobulins G, A, M, and E in nasal mucosa was studied in frozen biopsy sections of nasal turbinate from 16 allergic patients and 8 controls. The immunoperoxidase technique was used with monoclonal and polyclonal antibodies. Comparative analyses of serum immunoglobulin levels were also performed. Few B lymphocytes were observed in the nasal mucosa linings in specimens from allergic and non-allergic patients. In both groups, high positivity for IgG and IgA was observed in the nasal mucosa linings in the specimens. IgM concentration was minimal in both groups. IgE was absent in the nasal turbinate specimens of nonallergic subjects, but was present discontinuously in low concentrations in 7 of the 16 allergic patients. There was no significant difference between allergic and nonallergic patients in the tissue and serum IgG, IgA, and IgM concentrations found. IgE was detected slightly in the nasal mucosa of patients with high IgE serum concentrations (greater than 1000 IU/mL) as well as in patients with very low IgE serum concentration readings. This result raises some doubt on the hypothesis concerning the local production of IgE.
authors.affiliation: Institute of Otolaryngology, School of Medicine, University of Naples, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Testa
authors.forename: L
authors.initials: L
authors.lastname: Cuccurullo
authors.forename: C
authors.initials: C
authors.lastname: Mesolella
authors.forename: F
authors.initials: F
authors.lastname: Ferraraccio
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D001706:Biopsy; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D007073:Immunoglobulin E / Q000032:analysis* / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007075:Immunoglobulin M / Q000032:analysis / Q000097:blood; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology* / Q000473:pathology; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology* / Q000473:pathology; D014420:Turbinates / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007073:Immunoglobulin E