title: The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes.
abstract: The T cell growth factor IL-2 induces T cell progression through the cell cycle and ultimately controls T cell mitosis. Here we show that the guanine nucleotide-binding proteins p21ras may be involved in IL-2 signal transduction pathways. IL-2 causes a rapid and prolonged activation of p21ras in both murine and human T cells. The concentration-dependence of IL-2-mediated stimulation of p21ras correlated with IL-2 stimulation of T cell proliferation, which indicates that p21ras activity can be controlled by signals generated via the interaction between IL-2 and its high affinity cellular receptor. These results suggest that p21ras may play a role in the regulation of T cell growth by IL-2.
authors.affiliation: Lymphocyte Activation Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, U.K.
authors.forename: J D
authors.initials: JD
authors.lastname: Graves
authors.forename: J
authors.initials: J
authors.lastname: Downward
authors.forename: M
authors.initials: M
authors.lastname: Izquierdo-Pastor
authors.forename: S
authors.initials: S
authors.lastname: Rayter
authors.forename: P H
authors.initials: PH
authors.lastname: Warne
authors.forename: D A
authors.initials: DA
authors.lastname: Cantrell
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology; D017252:CD3 Complex; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D020558:GTP Phosphohydrolases / Q000502:physiology; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis* / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D007376:Interleukin-2; D011948:Receptors, Antigen, T-Cell; D015375:Receptors, Interleukin-2; D006160:Guanosine Triphosphate; D004247:DNA; D020558:GTP Phosphohydrolases; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)