title: [IgA, IgM and IgG levels and antibodies to native DNA and collagen type II in the perilymph of patients with otosclerosis].
abstract: Investigation of IgA, IgM and IgG levels in the serum of 20 and perilymph of 10 otosclerosis patients discovered a significant rise in the IgG concentrations versus control values. Five otosclerosis patients demonstrated perilymph and serum antibodies to collagen type II. Perilymph of 5 and sera of 10 otosclerosis patients exhibited a high titer of antibodies to native DNA specific for autoimmune process. The findings evidence immune disturbances in otosclerosis proving participation of autoimmune mechanisms in the disease pathogenesis. The results may be helpful in design of the conservative treatments of otosclerosis hypoacusis.
authors.forename: N N
authors.initials: NN
authors.lastname: Reshetnikov
authors.forename: T I
authors.initials: TI
authors.lastname: Popova
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D010040:Otosclerosis / Q000235:genetics / Q000276:immunology*; D010498:Perilymph / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D003094:Collagen; D004247:DNA
vernacular_title: Issledovanie urovnia immunoglobulinov klassov A-, M-, G, antitel k nativnoĭ DNK i kollagenu tipa II v perilimfe bol'nykh otosklerozom.