title: The effect of 5-HT3 receptor antagonists on the discriminative stimulus effects of amphetamine.
abstract: The discriminative stimulus induced in rats by amphetamine has previously been shown to be due to raised mesolimbic dopamine levels. As 5-HT3 receptor antagonists have been shown to inhibit hyperactivity resulting from raised mesolimbic dopamine levels, the present study examined their effects against the amphetamine discriminative stimulus. None of the 5-HT3 receptor antagonists tested (MDL 72,222EF, 0.3-10 mg/kg s.c.; MDL 73,147EF, 0.3-10 mg/kg s.c.; ICS 205-930, 0.01-10.0 mg/kg s.c.; ondansetron, 0.1-1000 micrograms/kg s.c.) antagonised the effects of amphetamine in this test. This suggests that 5-HT3 receptors cannot modulate the effects of raised mesolimbic dopamine in pathways involved in the interoceptive effects of amphetamine.
authors.affiliation: Marion Merrell Dow Research Institute, Strasbourg, France.
authors.forename: P C
authors.initials: PC
authors.lastname: Moser
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008297:Male; D017294:Ondansetron; D011807:Quinolizines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014326:Tropanes / Q000494:pharmacology; D000077526:Tropisetron
chemical_list: D007093:Imidazoles; D007211:Indoles; D011807:Quinolizines; D012702:Serotonin Antagonists; D014326:Tropanes; D017294:Ondansetron; D000077526:Tropisetron; C060344:dolasetron; D000661:Amphetamine; C042253:bemesetron