title: [A clinical study of the significance of the gradient between feeding arterial tissue polypeptide antigen (TPA) and draining venous TPA in assessing the risk for recurrent breast cancers].
abstract: The incidence of postoperative recurrence of primary breast cancers in 73 patients was correlated with the blood levels of tissue polypeptide antigen (TPA) in peripheral veins (V-TPA), feeding arteries (A-TPA), draining veins (V-TPA) and the gradient between the TAP levels in draining veins and feeding arteries (V-A TPA). With progression in the stage of the cancers, all parameters were increased. In stages II and III, the mean level of V-TPA was significantly higher than the mean level of A-TPA (p less than 0.05). In each stage, each parameter was increased in the patients with recurrences when compared with the levels in the patients with no recurrences. In patients with V-A TPA gradients greater than 30 U/L, the rate of recurrence was significantly higher when compared with patients with gradients less than 30 U/L (p less than 0.05). The clinical significance of this finding is that patients with V-A TPA gradient greater than 30 U/L should be closely followed because of the increased risk of recurrences.
authors.affiliation: Department of Surgery, School of Medicine, Shinshu University, Matsumoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Komatsu
authors.forename: O
authors.initials: O
authors.lastname: Senga
authors.forename: N
authors.initials: N
authors.lastname: Hanamura
authors.forename: M
authors.initials: M
authors.lastname: Fujimori
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: A
authors.initials: A
authors.lastname: Sugenoya
authors.forename: F
authors.initials: F
authors.lastname: Iida
mesh_terms: D001940:Breast / Q000098:blood supply*; D001943:Breast Neoplasms / Q000098:blood supply* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010455:Peptides / Q000097:blood*; D012306:Risk; D019396:Tissue Polypeptide Antigen
chemical_list: D010455:Peptides; D019396:Tissue Polypeptide Antigen