The influence of platelet-graft interaction on platelet survival in patients with aortobifemoral Dacron grafts.
In patients with arterial grafts, platelet consumption may be due either to platelet interaction with the graft, and/or concomitant platelet consumption in the rest of the arterial tree. This hypothesis was tested by quantifying the kinetics and platelet-graft interaction of indium-111-labelled platelets with double velour Dacron grafts in 13 patients with arterial insufficiency ascribed to atherosclerosis. Mean platelet lifespan (MPLS), 149 +/- 46 hours, was significantly shorter (P = 0.001) than normal. Labelled platelets were transiently deposited onto the graft surfaces. Peak 111In deposition on the grafts, 1.33 +/- 1.02% of injected labelled platelets, was reached at 70 +/- 33 hours. Thereafter the graft-platelet radioactivity decreased in parallel with platelet radioactivity in the circulation. There was no statistical correlation between MPLS and the factors known to be associated with graft platelet deposition: graft size; peak graft radioactivity; and the time to attain peak graft radioactivity. It is therefore concluded that in patients with arterial disease requiring graft implantation, the observed increased platelet consumption cannot only be ascribed to the interaction of platelets with the graft. Concomitant atherosclerosis is probably the important modifier of platelet consumption. The significant contribution of this factor to the shortening of the MPLS should be taken into account when assessing, by measuring platelet lifespan, the thrombogenicity of grafts.
Kotzé
H F
HF
Department of Haematology, University of the Orange Free State, Bloemfontein.
Heyns
A D
AD
Nel
C J
CJ
Roodt
J P
JP
Herbst
C P
CP
Badenhorst
P N
PN
Lötter
M G
MG
D000368:Aged; D001011:Aorta / Q000601:surgery; D001792:Blood Platelets / Q000502:physiology*; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D002470:Cell Survival; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D006083:Graft Occlusion, Vascular; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011093:Polyethylene Terephthalates
D007205:Indium Radioisotopes; D011093:Polyethylene Terephthalates