The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture's syndrome).
Despite numerous reports suggesting a relationship between hydrocarbon exposure and Goodpasture's syndrome, the nature of this association is still undefined. The present review was motivated by a patient with Goodpasture's syndrome who wondered if his illness was employment related. The patient had been working in an automobile servicing garage, where he was in frequent contact with a wide array of hydrocarbon solvents. Previous reports linking hydrocarbon exposure to Goodpasture's syndrome and anti-GBM antibody-mediated nephritis are analysed. A total of seventeen papers presenting 31 patient with hydrocarbon exposure and anti-GBM antibody-mediated disease are reviewed. The results suggest a causal relationship. Specific hydrocarbons implicated as potential toxins are listed, epidemiologic data are reviewed, and the association with cigarette smoking is discussed.
Bombassei
G J
GJ
Department of Medicine, University of Connecticut Health Center, Farmington 06032.
Kaplan
A A
AA
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis / Q000209:etiology*; D005921:Glomerulonephritis / Q000209:etiology; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D006838:Hydrocarbons / Q000009:adverse effects*; D008171:Lung Diseases / Q000209:etiology; D008297:Male; D009784:Occupational Diseases / Q000209:etiology*
D006838:Hydrocarbons