title: Preliminary study of a pregnanolone emulsion (Kabi 2213) for i.v. induction of general anaesthesia.
abstract: Pregnanolone emulsion was administered i.v. to 13 healthy male volunteers to assess its potential as an agent for i.v. induction of general anaesthesia and to establish a pharmacokinetic profile at two doses. Each subject received 0.5 mg kg-1, 0.75 mg kg-1 and 1.0 mg kg-1 on successive occasions, the rate of administration being constant for each dose. Pregnanolone emulsion was found to produce smooth and reliable induction of general anaesthesia with cardiorespiratory effects comparable to those of other i.v. induction agents.
authors.affiliation: Medeval Clinical Investigation Unit, University of Manchester.
authors.forename: H S
authors.initials: HS
authors.lastname: Gray
authors.forename: B L
authors.initials: BL
authors.lastname: Holt
authors.forename: D K
authors.initials: DK
authors.lastname: Whitaker
authors.forename: P
authors.initials: P
authors.lastname: Eadsforth
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000493:pharmacokinetics; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D005217:Fat Emulsions, Intravenous; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D011280:Pregnanolone / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000777:Anesthetics; D005217:Fat Emulsions, Intravenous; D011280:Pregnanolone