title: [Change in the drug-metabolizing function of the liver in patients in the postoperative period in relation to the type of anesthesia].
abstract: Anesthesia-dependent changes in pharmaco-metabolic liver function have been studied in patients operated on for cosmetic facial defects. It has been established that the postoperative period in patients subjected intraoperatively to general combined anesthesia and controlled lung ventilation was characterized by inhibited drug metabolism in the liver, which required correction of the drug doses to reduce the risk of side and toxic effects of pharmacotherapy. Patients operated on under local procaine anesthesia had no considerable changes in pharmaco-metabolic liver function in the postoperative period.
authors.forename: M E
authors.initials: ME
authors.lastname: Krakovskiĭ
authors.forename: M I
authors.initials: MI
authors.lastname: Azimov
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Ashirmetov
mesh_terms: D000328:Adult; D000772:Anesthesia, Local; D006591:Hexobarbital; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008875:Middle Aged; D009458:Neuroleptanalgesia; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011184:Postoperative Period; D011343:Procaine
chemical_list: D004364:Pharmaceutical Preparations; D011343:Procaine; D006591:Hexobarbital
vernacular_title: Izmenenie farmakometaboliziruiushcheĭ funktsii pechenii u bol'nykh v posleoperatsionnom periode v zavisimosti vida anestezii.