Increased PIVKA-II concentrations in patients with cystic fibrosis.
Serum vitamin K concentrations and prothrombin induced by absence of vitamin K (PIVK-II) concentrations were assayed in 43 patients with cystic fibrosis. Twenty nine showed a normal PIVKA-II and vitamin K concentrations; 14 showed an increased PIVKA-II concentration, in one of whom serum vitamin K was decreased. Although their vitamin K concentrations were normal, some patients with cystic fibrosis still had an increased PIVKA-II. There was a significant correlation between PIVKA-II concentrations and the administration of antibiotics, a factor which has not previously been considered responsible for an increase in PIVKA-II.
de Montalembert
M
M
Département de Pédiatrie, Hôpital des Enfants-Malades, Paris.
Lenoir
G
G
Saint-Raymond
A
A
Rey
J
J
Lefrère
J J
JJ
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D011516:Prothrombin / Q000032:analysis*; D014810:Vitamin E / Q000097:blood; D014812:Vitamin K / Q000097:blood*; D014813:Vitamin K Deficiency / Q000097:blood
D000900:Anti-Bacterial Agents; D014812:Vitamin K; D014810:Vitamin E; D011516:Prothrombin