title: Single- versus triple-lumen central catheter-related sepsis: a prospective randomized study in a critically ill population.
abstract: OBJECTIVE
  A prospective randomized study was conducted over a 23-month period in an adult medical-surgical intensive care unit to determine whether triple-lumen catheters reduce the need for peripheral vascular access and whether they are associated with a higher rate of infection than single-lumen catheters.
  
  
  METHODS
  After the insertion route, internal jugular or subclavian, was selected by the physician, patients were randomized either to single-lumen or triple-lumen catheter groups. Complementary peripheral vascular access was allowed in both groups. Catheters were removed according to preestablished defined reasons: suspicion of catheter-related sepsis, uselessness of central venous access, duration of catheterization of more than 21 days, discharge from the intensive care unit, or death.
  
  
  RESULTS
  Data on 129 central venous catheters were collected from 91 consecutive patients. Twenty-five of 68 patients from the single-lumen group and 1 of 61 patients from the triple-lumen group needed peripheral vascular access (p less than 0.001). Catheter-related sepsis rates, defined either by clinical signs and positive qualitative tip cultures (8.9% versus 11.5%) or by quantitative tip cultures (16.2% versus 11.5%), were identical in the single-lumen and triple-lumen groups (type II error: 8%).
  
  
  CONCLUSIONS
  In intensive care units, the use of triple-lumen catheters is associated with a dramatic decrease in the need for peripheral vascular access. The incidence of central venous catheter-related sepsis appears identical for single- and triple-lumen catheters.
authors.affiliation: Service de Réanimation Polyvalente, Hôpital Saint Joseph, Paris, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Farkas
authors.forename: N
authors.initials: N
authors.lastname: Liu
authors.forename: J P
authors.initials: JP
authors.lastname: Bleriot
authors.forename: S
authors.initials: S
authors.lastname: Chevret
authors.forename: F W
authors.initials: FW
authors.lastname: Goldstein
authors.forename: J
authors.initials: J
authors.lastname: Carlet
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness; D004867:Equipment Design; D005260:Female; D006801:Humans; D007239:Infections / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies