Platelet-activating factor in Japanese cedar pollinosis.
The concentration of lyso-PAF in serum from untreated patients with Japanese cedar pollinosis, a typical allergic disease, was significantly higher than that in healthy controls. It was also found that the lyso-PAF level in serum from Japanese cedar pollinosis significantly decreased after therapy with ketotifen, an anti-allergic drug. These results suggest that PAF might play an important role in Japanese cedar pollinosis and that the clinical effect of anti-allergic drug might be partially due to the anti-PAF action.
Nakamura
T
T
Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
Ishihara
K
K
Kuriyama
M
M
Ito
K
K
Matsumura
Y
Y
D000328:Adult; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000378:metabolism*; D007665:Ketotifen / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000378:metabolism*; D011058:Pollen; D014197:Trees
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D007665:Ketotifen