Identification of immunoglobulin recombinant elements in human immunodeficiency virus type 1 envelope gene.
Recently, it has been recognised that the amino acid motif VQL(N/V)ES is shared between the second conserved domain of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp120) and the first framework (FW1) of human IgG heavy chain variable region (subgroup III) (VHIII). We have found that nucleotide sequence corresponding to this motif contains some recombination elements characteristic for the genes of human Ig heavy-chain variable region. The possible role of the Ig recombination elements in HIV-1 envelope gene variability, AIDS pathogenesis and vaccine design is discussed.
Veljković
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V
Laboratory of Multidisciplinary Research, Boris Kidric Institute, Belgrade, Yugoslavia.
Metlas
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R
D000595:Amino Acid Sequence; D001483:Base Sequence; D016384:Consensus Sequence; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid
D015699:HIV Envelope Protein gp120; D007135:Immunoglobulin Variable Region