[Mannitol reduces plasma hydrogen peroxide free radical in patients undergoing coronary artery bypass graft surgery].
During the procedure of coronary artery bypass graft surgery (CABG), the release of free oxygen radicals as a result of ischemia and reperfusion which plants the seeds of post-operative low cardiac output and arrhythmias has grave consequence on the reestablishment of cardiac function. A variety of chemical agents such as mannitol, allopurinol, catalase (Q-10) and superoxide dismutase (SOD) has proved to be considerably effective to improve the myocardial necrosis following ischemia and reperfusion. In this study we chose mannitol (0.2 gm/kg) as the free oxygen radicals scavenger and utilized mass spectrophotometric method to detect the variation of concentration of [H2O2], a by-product of free oxygen radical, in an attempt to evaluate the efficacy of mannitol in this regard in patients undergoing CABG. Patients were divided into experimental group (n = 19) and control group (n = 20). In the experimental group the concentration of [H2O2] changed from 61 +/- 24 microM/L pre-operatively to 77 +/- 18 microM/L post-operatively as against 75 +/- 31 microM/L and 99 +/- 31 microM/L respectively in the control group. In comparison, only the change in experimental group was statistically significant (p less than 0.05). We confirmed that mannitol functions considerably as a free oxygen radical scavenger since it reduces the production of [H2O2] in patients undergoing CABG.
Yang
M W
MW
Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Lin
C Y
CY
Hung
H L
HL
Chan
K H
KH
Lin
K Y
KY
Lee
T Y
TY
Chan
S H
SH
D000368:Aged; D001026:Coronary Artery Bypass; D005260:Female; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D008875:Middle Aged
D005609:Free Radicals; D008353:Mannitol; D006861:Hydrogen Peroxide