Absorption of amorolfine through human nail.
The percutaneous absorption of a new antifungal agent, amorolfine, has been measured through both skin and nail using an in vitro technique. Application of a 5% concentration in either an ethanol or methylene chloride lacquer resulted in permeation rates through nail in the range of 20-100 ng/cm2/h and somewhat higher through skin. Absorption was greater from the methylene chloride lacquer than the ethanol lacquer.
Franz
T J
TJ
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock.
D000042:Absorption; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D000431:Ethanol / Q000008:administration & dosage; D006801:Humans; D066298:In Vitro Techniques; D007764:Lacquer; D008752:Methylene Chloride / Q000008:administration & dosage; D009025:Morpholines / Q000493:pharmacokinetics*; D009262:Nails / Q000378:metabolism*; D012869:Skin Absorption / Q000187:drug effects
D000935:Antifungal Agents; D009025:Morpholines; D000431:Ethanol; D008752:Methylene Chloride; C038974:amorolfine