title: [Mannitol reduces plasma hydrogen peroxide free radical in patients undergoing coronary artery bypass graft surgery].
abstract: During the procedure of coronary artery bypass graft surgery (CABG), the release of free oxygen radicals as a result of ischemia and reperfusion which plants the seeds of post-operative low cardiac output and arrhythmias has grave consequence on the reestablishment of cardiac function. A variety of chemical agents such as mannitol, allopurinol, catalase (Q-10) and superoxide dismutase (SOD) has proved to be considerably effective to improve the myocardial necrosis following ischemia and reperfusion. In this study we chose mannitol (0.2 gm/kg) as the free oxygen radicals scavenger and utilized mass spectrophotometric method to detect the variation of concentration of [H2O2], a by-product of free oxygen radical, in an attempt to evaluate the efficacy of mannitol in this regard in patients undergoing CABG. Patients were divided into experimental group (n = 19) and control group (n = 20). In the experimental group the concentration of [H2O2] changed from 61 +/- 24 microM/L pre-operatively to 77 +/- 18 microM/L post-operatively as against 75 +/- 31 microM/L and 99 +/- 31 microM/L respectively in the control group. In comparison, only the change in experimental group was statistically significant (p less than 0.05). We confirmed that mannitol functions considerably as a free oxygen radical scavenger since it reduces the production of [H2O2] in patients undergoing CABG.
authors.affiliation: Department of Anesthesiology, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: M W
authors.initials: MW
authors.lastname: Yang
authors.forename: C Y
authors.initials: CY
authors.lastname: Lin
authors.forename: H L
authors.initials: HL
authors.lastname: Hung
authors.forename: K H
authors.initials: KH
authors.lastname: Chan
authors.forename: K Y
authors.initials: KY
authors.lastname: Lin
authors.forename: T Y
authors.initials: TY
authors.lastname: Lee
authors.forename: S H
authors.initials: SH
authors.lastname: Chan
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D005260:Female; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D008875:Middle Aged
chemical_list: D005609:Free Radicals; D008353:Mannitol; D006861:Hydrogen Peroxide