Lipocortins (annexins) 1, 2, 4 and 5 are increased in the central nervous system in multiple sclerosis.
Western blotting and densitometry have been used to investigate the lipocortin content of post-mortem central nervous system (CNS) tissue samples from multiple sclerosis (MS) patients and normal controls. Lipocortins 1, 2, 4 and 5 were all detected in normal control grey and white matter. In white matter samples from MS patients these lipocortins were found to be significantly increased, a further elevation in lipocortin content was observed in MS plaque tissue. The implications of these findings with respect to the role of these proteins in inflammatory CNS disease and a possible mechanism of steroid action in the therapy of MS are discussed.
Elderfield
A J
AJ
School of Pharmacy and Pharmacology, University of Bath, UK.
Newcombe
J
J
Bolton
C
C
Flower
R J
RJ
D000328:Adult; D000368:Aged; D017302:Annexins; D015153:Blotting, Western; D002102:Cadaver; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism*; D003720:Densitometry; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism*; D010740:Phospholipases / Q000037:antagonists & inhibitors; D012016:Reference Values; D014018:Tissue Distribution
D017302:Annexins; D002135:Calcium-Binding Proteins; D010740:Phospholipases