title: Intratumor treatment of C3H mouse mammary carcinoma with 5-fluorouracil adsorbed on activated charcoal particles.
abstract: A dosage form comprising 5-fluorouracil (5-FU, 25 mg/ml) adsorbed on a suspension of micronized charcoal (100 mg/ml) 2-5 microns in diameter, adsorbing 5-FU in aqueous solution was studied for intratumor treatment of mammary carcinoma in animal experiments. An in vitro desorption method is described to determine the amount of 5-FU adsorbed on activated charcoal particles which would be released once the drug concentration decreased around the charcoal. In vivo results indicate that an intratumor injection of 5-FU adsorbed on activated charcoal particles is a highly effective method for achieving tumor regression without increasing toxicity.
authors.affiliation: Laboratoire de Pharmacie, Hôpital Paul Brousse, Villejuif, France.
authors.forename: L
authors.initials: L
authors.lastname: Bonhomme
authors.forename: M C
authors.initials: MC
authors.lastname: Mathieu
authors.forename: D
authors.initials: D
authors.lastname: Amdidouche
authors.forename: E
authors.initials: E
authors.lastname: Faure
authors.forename: D
authors.initials: D
authors.lastname: Guisteau
authors.forename: G
authors.initials: G
authors.lastname: Fredj
authors.forename: S
authors.initials: S
authors.lastname: Naveau
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000327:Adsorption; D000818:Animals; D002606:Charcoal; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D013535:Suspensions
chemical_list: D013535:Suspensions; D002606:Charcoal; D005472:Fluorouracil