Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease.
Huntington disease is a neurological movement disorder involving massive neuronal death in the caudate-putamen region of the brain. Neither preventive nor curative therapy exists for this disease. The implantation of cross-species striatal neural precursor cells into the lesioned striatum of nonhuman primates (baboons) reduced the abnormal movements seen in the disease model. These abnormal movements reappeared after immunological rejection of the implanted striatal cells and were not modified by transplantation with nonstriatal cells. These findings encourage further experimentation toward the use of cell sources other than human fetal cells in a potential clinical application to Huntington disease.
Hantraye
P
P
Centre National de la Recherche Scientifique, Département de Recherche en Imagerie, Pharmacologie et Physiologie, Orsay, France.
Riche
D
D
Maziere
M
M
Isacson
O
O
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000166:cytology / Q000637:transplantation*; D004195:Disease Models, Animal; D005333:Fetus; D006816:Huntington Disease / Q000628:therapy*; D007165:Immunosuppression Therapy; D010215:Papio; D012044:Regression Analysis; D014183:Transplantation, Heterologous
D001058:Apomorphine