[Local recurrence of breast cancer: prognostic factors, effect of adjuvant therapy].
Local recurrence after treatment of operable breast cancer occurred in about 20% of the patients before adjuvant therapy became common. The incidence of local recurrence is high during the first 2 years of follow-up, becomes lower afterwards, and is less than 1% after 10 years follow-up. Some primary tumor characteristics have been recognized as risk factors for the development of a local recurrence: size of the primary tumor, its histology and malignancy grade, number of involved axillary lymph nodes. The type and extent of primary tumor treatment, and additional adjuvant therapy are also factors influencing the frequency of local recurrence. Data from MD Anderson Hospital and from the Ludwig Study III are used to show the impact of adjuvant therapy upon local recurrence frequency.


CONCLUSIONS
local recurrence after treatment of breast cancer is becoming less frequent, especially after introduction of adjuvant therapy. The question of additional systemic therapy after excision of local recurrences is still open, and is studied in a clinical trial of the Swiss Group of Clinical Cancer Research.
Castiglione-Gertsch
M
M
Institut für medizinische Onkologie der Universität, Inselspital, Bern.
D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
Lokalrezidive beim Mammakarzinom: prognostische Faktoren, Einfluss der adjuvanten Therapie.