title: [Neuroblastoma, factor of early decompensation of tetralogy of Fallot].
abstract: The authors report the case of a tetralogy of Fallot associated with a neuroblastoma secreting large quantities of noradrenaline. Anoxic decompensation of the tetralogy of Fallot occurred early at the age of 4 months with cyanotic crises associated with an impression of abdominal pain. A systemic-pulmonary anastomosis was performed and the cyanosis regressed but the crises persisted and investigations showed the presence of a neuroblastoma. The tumour was treated by surgery and chemotherapy and has not recurred after 2 years' follow-up. Complete repair of the tetralogy of Fallot was performed secondarily at the age of 2. In this case, the high concentration of circulating catecholamines was probably a factor of early decompensation of the tetralogy of Fallot by infundibular spasm. A review of the literature revealed 26 cases of cardiac disease with a peripheral neurogenic tumour. Two pathogenic mechanisms are suggested: an embryological abnormality of cardiac cell migration from the neural crest and chronic stimulation of neuroblastic cells by chronic hypoxia.
authors.affiliation: Unité de cardio-pneumologie pédiatrique, hôpital Saint-Charles, Montpellier.
authors.forename: M
authors.initials: M
authors.lastname: Voisin
authors.forename: S
authors.initials: S
authors.lastname: Guillaumont
authors.forename: G
authors.initials: G
authors.lastname: Margueritte
authors.forename: F
authors.initials: F
authors.lastname: Bernard
authors.forename: R B
authors.initials: RB
authors.lastname: Galifer
authors.forename: G
authors.initials: G
authors.lastname: Barneon
authors.forename: A
authors.initials: A
authors.lastname: Couture
mesh_terms: D006801:Humans; D007223:Infant; D008297:Male; D009432:Neural Crest; D009447:Neuroblastoma / Q000150:complications / Q000151:congenital* / Q000628:therapy; D009638:Norepinephrine / Q000097:blood; D013771:Tetralogy of Fallot / Q000150:complications* / Q000601:surgery; D013899:Thoracic Neoplasms / Q000150:complications / Q000151:congenital* / Q000628:therapy
chemical_list: D009638:Norepinephrine
vernacular_title: Neuroblastome facteur de décompensation précoce d'une tétralogie de Fallot.