A specific T-cell receptor genotype preference in the immune response to a synthetic Plasmodium falciparum malaria vaccine.
In recent studies with 63 and 122 volunteers vaccinated with the SPf 66 synthetic malaria vaccine, specific antibody patterns were classified as high or low responders. Using the Polymerase Chain Reaction (PCR), a specific and selective preference was shown for the V beta arrangement of the T-cell receptor in the high responder group involving the V beta-8 gene. The low responder group showed the rearrangement of a different set of genes, and a particular association with V beta-10.
Murillo
L A
LA
Instituto de Inmunologia, Hospital San Juan de Diós, Universidad Nacional de Colombia, Bogotá.
Tenjo
F A
FA
Clavijo
O P
OP
Orozco
M A
MA
Sampaio
S
S
Kalil
J
J
Patarroyo
M E
ME
D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D001483:Base Sequence; D015321:Gene Rearrangement / Q000276:immunology; D005803:Genes, Immunoglobulin / Q000276:immunology; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000276:immunology* / Q000517:prevention & control; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D010963:Plasmodium falciparum / Q000276:immunology*; D016133:Polymerase Chain Reaction; D015800:Protozoan Proteins / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics* / Q000276:immunology; D011994:Recombinant Proteins; D013601:T-Lymphocytes / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology*
D000913:Antibodies, Protozoan; D015345:Oligonucleotide Probes; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D016693:Receptors, Antigen, T-Cell, alpha-beta; D011994:Recombinant Proteins; C066269:SPf66 protein, Plasmodium; D014614:Vaccines, Synthetic