title: Metabolism of albendazole and albendazole sulphoxide by ruminal and intestinal fluids of sheep and cattle.
abstract: 1. The metabolism of albendazole (ABZ), albendazole sulphoxide (ABZSO) and albendazole sulphone (ABZSO2) by ruminal, abomasal and ileal fluids of sheep and cattle was investigated under anaerobic conditions in vitro. 2. None of the compounds was metabolically changed by incubation with abomasal fluids of sheep and cattle. 3. ABZ and ABZSO were extensively metabolized by sheep and cattle ruminal and ileal fluids. ABZSO2 was unaffected by incubation with these gastrointestinal fluids. 4. The rate of ABZ oxidation into ABZSO was greater for cattle ruminal and ileal fluids than for sheep fluids. 5. ABZSO was reduced back to ABZ by ruminal and ileal fluids of both species. This reducing activity was significantly higher for both ruminal and ileal fluids of sheep compared with those of cattle.
authors.affiliation: Institute of Parasitology, McGill University, Macdonald Campus, Québec, Canada.
authors.forename: C E
authors.initials: CE
authors.lastname: Lanusse
authors.forename: B
authors.initials: B
authors.lastname: Nare
authors.forename: L H
authors.initials: LH
authors.lastname: Gascon
authors.forename: R K
authors.initials: RK
authors.lastname: Prichard
mesh_terms: D000018:Abomasum / Q000378:metabolism; D015766:Albendazole / Q000031:analogs & derivatives* / Q000378:metabolism*; D000818:Animals; D000871:Anthelmintics / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D002417:Cattle; D008658:Inactivation, Metabolic; D007413:Intestinal Mucosa / Q000378:metabolism*; D010084:Oxidation-Reduction; D012417:Rumen / Q000378:metabolism; D012756:Sheep; D013279:Stomach, Ruminant / Q000378:metabolism*
chemical_list: D000871:Anthelmintics; D015766:Albendazole; C027186:albendazole sulfoxide