Effect of duration of hepatitis B virus infection on the association between human immunodeficiency virus type-1 and hepatitis B viral replication.
This study examined the effect of duration of hepatitis B virus infection on the association between human immunodeficiency virus type-1 infection and hepatitis B viral replication. Twenty-five chronic HBsAg carriers were studied. Presence of hepatitis B virus DNA and expression of HBeAg were more frequent among 20 chronic HBsAg carriers positive for human immunodeficiency virus type-1 antibody compared with five chronic HBsAg carriers negative for human immunodeficiency virus type-1 antibody, but the associations were not statistically significant. Hepatitis B virus DNA and HBeAg were inversely related to duration of hepatitis B virus infection (p less than 0.001). Stratifying for duration of hepatitis B virus infection, the presence of viral replication was similar among patients negative and positive for antibody to human immunodeficiency virus type-1. Hepatitis B virus DNA levels did not increase with the decline of cellular immunity over time. In conclusion, hepatitis B virus replication among chronic carriers may be a function of duration of hepatitis B virus infection rather than of an effect of human immunodeficiency virus type-1.
Koblin
B A
BA
Wolf Szmuness Laboratory of Epidemiology, New York Blood Center, New York 10021.
Taylor
P E
PE
Rubinstein
P
P
Stevens
C E
CE
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology / Q000382:microbiology*; D016516:CD4-CD8 Ratio; D004279:DNA, Viral / Q000032:analysis; D015497:HIV-1 / Q000502:physiology*; D006509:Hepatitis B / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008297:Male; D013997:Time Factors; D014779:Virus Replication
D004279:DNA, Viral; D006513:Hepatitis B e Antigens