title: Effects of particulate matter exposure and medication use on asthmatics.
abstract: The health risk associated with low-level air pollution exposure is still uncertain. The association between exposure and pulmonary function was assessed with personal sampling. Small, portable multipollutant samplers were used to assess personal exposure to particulate matter. Thirty-six asthmatic subjects participated in the study for up to 20 d in both summer (n = 10 d) and winter (n = 10 d); pulmonary function was assessed at the beginning and end of each sampling day, and medication use was recorded. A within-individual longitudinal analysis of the relationship between pulmonary function and particulate matter revealed an effect of season. In winter, pulmonary function increased as particulate exposure increased, which was explained by a confounding effect of medication use. Therefore, in addition to exposure, season of the year and medication use are factors that must be considered.
authors.affiliation: Gage Research Institute, University of Toronto, Ontario, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Silverman
authors.forename: H R
authors.initials: HR
authors.lastname: Hosein
authors.forename: P
authors.initials: P
authors.lastname: Corey
authors.forename: S
authors.initials: S
authors.lastname: Holton
authors.forename: S M
authors.initials: SM
authors.lastname: Tarlo
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D010316:Particle Size; D012621:Seasons; D014797:Vital Capacity
chemical_list: D000393:Air Pollutants