Low concentration endothelin-1 enhanced histamine-mediated bronchial contractions of guinea pigs in vivo.
Endothelin-1 (ET-1) represents one of the most potent constrictors of guinea pig bronchial smooth muscle. In our study, various doses of aerosolized ET-1 increased airway resistance. But a very low concentration of ET-1 (10(-12) M) could not change airway resistance. We examined low doses of ET-1 enhanced the sensitivity of bronchial contractions to histamine. ET-1 may play one of the most important roles in contributing directly or indirectly to the pathogenesis of bronchial asthma.
Kanazawa
H
H
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Kurihara
N
N
Hirata
K
K
Fujiwara
H
H
Matsushita
H
H
Takeda
T
T
D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000008:administration & dosage / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology
D000336:Aerosols; D016232:Endothelins; D006632:Histamine