Risk factors in normolipidemic male patients with coronary artery disease in Japanese.
We examined serum lipids, lipoproteins, apolipoproteins (Apo), lipoprotein(a) (Lp(a)), C4b-binding protein (C4bp) and lathosterol in 22 normolipidemic (serum total cholesterol less than 220 mg/dl and serum triglycerides less than 150 mg/dl) male patients with coronary artery disease (CAD) and 33 normal male subjects. Many of the patients in the CAD group with normal total cholesterol (T-Ch) and triglycerides (TG) had higher TG, low-density lipoprotein (LDL)-Ch, beta-lipoprotein (Lipo) and Apo B values and lower high-density lipoprotein (HDL)-Ch, Apo A-I and Apo A-II values than those of the control group. Differences were also observed in the beta-Lipo/HDL-Ch, Apo B/Apo A-I, and HDL-Ch ratios and the atherogenic index [A.I. = (T-Ch--HDL-Ch)/HDL-Ch], all of which are generally accepted as indices for atherosclerosis. Even in CAD patients with normolipidemia, the HDL-Ch/T-Ch ratio and A.I. seemed to be important risk factors. In addition, Lp(a) and lathosterol, an accepted indicator of whole-body cholesterol synthesis, were higher in the CAD group. The CAD group also appeared to have a higher C4bp value, suggesting that this parameter is correlated with other lipids.
Sonoda
M
M
Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Sakamoto
K
K
Miyauchi
T
T
Sanada
J
J
Nakamura
K
K
Arima
T
T
Kuriyama
M
M
Nagata
K
K
Osame
M
M
Miyahara
K
K
D002352:Carrier Proteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D006801:Humans; D016167:Integrin alphaXbeta2; D007564:Japan; D008297:Male; D012307:Risk Factors
D002352:Carrier Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D016167:Integrin alphaXbeta2; C001521:lathosterol; D002784:Cholesterol