Changes in left ventricular dimensions and systolic function in 100 mildly hypertensive men during one year's treatment with atenolol vs. hydrochlorothiazide and amiloride (Moduretic): a double-blind, randomized study.
In a randomized double-blind study to compare the effect of atenolol vs. hydrochlorothiazide and amiloride (Moduretic) on left ventricular dimensions and systolic function, 100 hypertensive men were followed up during 1 year of treatment, 50 subjects being randomized to each drug. Echocardiography was performed at baseline, and after 3 and 12 months of treatment. A significant reduction in left ventricular mass with atenolol was paralleled by a decrease in left ventricular wall thickness and an increase in stroke volume. A similar reduction of left ventricular mass with Moduretic without a change in relative wall thickness and a decrease in stroke volume was observed. Cardiac output decreased in both groups.
Otterstad
J E
JE
Medical Department, Vestfold Central Hospital, Toensberg, Norway.
Froeland
G
G
Wasenius Soeyland
A K
AK
Knutsen
K M
KM
Ekeli
T
T
D000328:Adult; D000368:Aged; D001262:Atenolol / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006332:Cardiomegaly / Q000175:diagnosis*; D004311:Double-Blind Method; D004452:Echocardiography; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D013599:Systole / Q000187:drug effects*; D013997:Time Factors
D006852:Hydrochlorothiazide; D001262:Atenolol; D009543:Nifedipine