Pharmacokinetic and metabolic aspects of the moclobemide-food interaction.
The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC increases) and on systemic clearance (AUC decreases) balance each other out.
Cole
A F
AF
Department of Anaesthesia, Mount Sinai Hospital, Toronto, Canada.
Baxter
J G
JG
Jackson
B J
BJ
Hew-Wing
P
P
Güntert
T W
TW
Lalka
D
D
D000293:Adolescent; D000328:Adult; D001549:Benzamides / Q000493:pharmacokinetics*; D001682:Biological Availability; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology; D005502:Food; D006801:Humans; D007208:Indocyanine Green; D007275:Injections, Intravenous; D008102:Liver Circulation / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D020912:Moclobemide
D001549:Benzamides; D004044:Dietary Proteins; D007208:Indocyanine Green; D020912:Moclobemide