Microsomal liver function declines steadily after kidney grafting: a three to five year follow-up.
We have previously shown that the functioning hepatocyte mass (galactose elimination capacity, GEC) and microsomal liver functions (non-renal clearances of unbound prednisolone and cyclosporin A) are impaired in renal allograft recipients (N = 28) one month and one year after successful transplantation. To assess the natural history of these hepatic functional derangements, we reinvestigated 21 patients with stable renal function three to five years following grafting. GEC remained with 6.07 +/- 0.86 mg/min x kg significantly (P less than 0.001) below that in healthy controls (7.52 +/- 0.78 mg/min x kg), but did not significantly change during follow-up (5.93 +/- 0.96 and 6.26 +/- 0.94 mg/min x kg at 1 year and 1 month, respectively). In contrast, the non-renal clearance of unbound prednisolone declined steadily during follow-up averaging 4.98 +/- 0.71 ml/min x kg at three to five (compared to 5.83 +/- 1.51 and 6.80 +/- 1.73 ml/min x kg at one year and one month, respectively). These values were lower (P less than 0.01) than those observed in healthy control subjects (7.56 +/- 1.59 ml/min x kg). The total body clearance of cyclosporin A decreased similarly with time averaging 4.5 +/- 1.2 ml/min x kg at three to five years (compared to 4.9 +/- 1.2 and 5.9 +/- 2.1 ml/min x kg at 1 year and 1 month, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Schaad
H J
HJ
Medizinische Poliklinik, University of Berne, Switzerland.
Frey
B M
BM
Renner
E L
EL
Preisig
R
R
Frey
F J
FJ
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D005500:Follow-Up Studies; D005690:Galactose / Q000493:pharmacokinetics; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D016030:Kidney Transplantation; D008862:Microsomes, Liver / Q000502:physiology*; D008875:Middle Aged; D011239:Prednisolone / Q000097:blood / Q000493:pharmacokinetics; D011241:Prednisone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D012016:Reference Values; D013997:Time Factors
D011239:Prednisolone; D011241:Prednisone; D005690:Galactose