Serum levels of mianserin and clinical outcome in elderly depressive inpatients.
Fifty-two elderly inpatients with moderate or severe depression underwent routine mianserin treatment with simultaneous measurements of 76 steady- state serum mianserin concentrations. These concentrations were correlated to the changes in the illness of the patients, who were divided into three classes according to the ratings by the Global Clinical Impression scale in steady-state and at two, four, and six weeks' intervals. Despite no significant differences in mean dosages, the serum mianserin concentrations of the patients with good clinical improvement were significantly higher than those of the patients with minimal clinical improvement, in six weeks of ratings. We conclude that some individual old patients have a correlation between good antidepressive effects and relatively high serum mianserin concentration.
Leinonen
E
E
Harjamäki Hospital, Siilinjärvi, Finland.
Rimón
R
R
D000368:Aged; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010552:Personality Assessment
D008803:Mianserin