Changes in endocrine control of electrolyte homeostasis and blood pressure following heart and heart-lung transplantation. A comparative study.
The purpose of this study was to compare the early postoperative effects of heart and heart-lung transplantation on the secretion of atrial natriuretic peptide (alpha-ANP), renin, aldosterone, and vasopressin. This was carried out from the first to the eighth postoperative day in ten heart and five heart-lung recipients. The changes in the release of these hormones were similar in both groups. Vasopressin release remained stable while that of the renin-angiotensin-aldosterone system progressively returned to more normal levels. Grafted heart tissue was capable of high alpha-ANP release early on in both heart and in heart-lung recipients. This sustained alpha-ANP release was not a function of the resulting overall atrial tissue mass. Our findings suggest that it might be the consequence of an intrinsic hypersecretion of alpha-ANP resulting from the loss of normal heart innervation occurring in both heart and heart-lung transplantation.
Mertes
P M
PM
Renal and Metabolic Function Exploration Laboratory, University of Nancy Medical Center (Centre Hospitalier Universitaire de Brabois), France.
de Talancé
N
N
Pinelli
G
G
Villemot
J P
JP
Burlet
C
C
Boulangé
M
M
D000328:Adult; D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001794:Blood Pressure / Q000502:physiology*; D001825:Body Fluid Compartments / Q000502:physiology; D004702:Endocrine Glands / Q000378:metabolism*; D005260:Female; D016027:Heart Transplantation / Q000502:physiology*; D016041:Heart-Lung Transplantation / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood; D014882:Water-Electrolyte Balance / Q000502:physiology*
D014667:Vasopressins; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin