title: Malignant hyperthermia. An historical vignette.
abstract: This paper reports previously unpublished accounts of the deaths in 1915 and 1919 of two members of the same family during general anaesthesia. The deaths were subsequently ascribed to a 'hereditary susceptibility' to chloroform. Contemporary evidence is presented which suggests that these deaths were among the very earliest examples of malignant hyperthermia to be described.
authors.affiliation: Department of Anaesthesia, University of Cape Town Medical School & Groote Schuur Hospital, Observatory, South Africa.
authors.forename: G G
authors.initials: GG
authors.lastname: Harrison
authors.forename: H
authors.initials: H
authors.lastname: Isaacs
mesh_terms: D002675:Child, Preschool; D002725:Chloroform / Q000009:adverse effects; D004198:Disease Susceptibility; D005260:Female; D049673:History, 20th Century; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000235:genetics / Q000266:history* / Q000401:mortality; D010375:Pedigree
chemical_list: D002725:Chloroform