The additive effect of alpha-difluoromethylornithine (DFMO) and radiation therapy on a rat glioma model.
The effects of alpha-difluoromethylornithine (DFMO), radiation and the therapy of their combination were investigated in rats bearing G-XII glioma. DFMO treatment as well as radiation therapy prolonged the survival period when compared to the results in non-treated control rats. The combination therapy showed a greater effect on the survival rate than the single therapies, the effect being additive. The concentration of putrescine, spermidine, and N1-acetylspermidine in tumor tissue was lowered by DFMO, while that of spermine was slightly elevated. Radiation decreased the concentration of all the polyamines, putrescine, spermidine, spermine and N1-acetylspermidine. The concomitant treatment with DFMO and radiation further decreased the concentrations of putrescine and N1-acetylspermidine in tumor tissues. The survival period of glioma-bearing rats is inversely correlated with the tissue levels of putrescine plus N1-acetylspermidine.
Tsukahara
T
T
Department of Neurosurgery, Gunma University School of Medicine, Maebashi, Japan.
Tamura
M
M
Yamazaki
H
H
Kurihara
H
H
Matsuzaki
S
S
D000818:Animals; D015317:Biogenic Polyamines / Q000032:analysis; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D000518:Eflornithine / Q000627:therapeutic use*; D005910:Glioma / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008297:Male; D051381:Rats
D015317:Biogenic Polyamines; D000518:Eflornithine