title: Evaluation of muscle flaps in the treatment of infected aortic grafts.
abstract: Standard therapy for abdominal aortic graft infection involving resection of the graft and extraanatomic bypass carries significant morbidity and mortality rates. The present study evaluates the feasibility of combining in situ graft replacement with a highly vascular tissue flap as an alternative to this problem. In 52 pigs a segment of a polytetrafluoroethylene graft was interposed in the infrarenal abdominal aorta. Staphylococcus aureus was used to infect the graft. One week later the animals were divided into six treatment groups. Group 1 (control) had debridement of the retroperitoneum only; group 2 had debridement with replacement of the graft; group 3 consisted of animals with the infected graft left in place and the graft wrapped with a rectus abdominis flap; group 4 is similar to group 3 except the seromuscularis of the jejunum was used to wrap the infected graft; in group 5 the graft was changed, and a rectus abdominis island flap was wrapped around the graft; and finally, group 6 was similar to group 5 except that the flap was obtained from the seromuscularis of the jejunum. Two weeks later, graft patency and infection status were assessed at reoperation. The incidence of graft infection was significantly reduced in groups 5 (0 of 10; p less than 0.01) and 6 (1 of 10; p less than 0.02) compared with group 1 (7 of 10), and the incidence of graft thrombosis was also greatly reduced in groups 5 (2 of 10) and 6 (1 of 10) versus group 1 (10 of 10; p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: R J
authors.initials: RJ
authors.lastname: Mehran
authors.forename: A M
authors.initials: AM
authors.lastname: Graham
authors.forename: M A
authors.initials: MA
authors.lastname: Ricci
authors.forename: J F
authors.initials: JF
authors.lastname: Symes
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D005240:Feasibility Studies; D009132:Muscles / Q000098:blood supply / Q000637:transplantation; D016459:Prosthesis-Related Infections / Q000601:surgery*; D013203:Staphylococcal Infections / Q000601:surgery; D013524:Surgical Flaps / Q000379:methods*; D013552:Swine