Bioavailability and toxicological potential of lentil-bound residues of malathion in rats.
Lentil grains treated with malathion and stored under laboratory conditions for 12 months formed bound residues. Bioavailability and the effects of lentil-bound residues of malathion in rats were studied. The amount of bound residues in lentils treated with 14C-malathion at 10 ppm and 50 ppm gradually increased to 9.52% and 13.01% of the initially applied doses after 12 months. When rats were fed these 14C-bound residues, radioactivity excreted in urine accounted for 34.49% of the administered dose. In feces, 26.15% of given dose was methanol-extractable while 18.67% was determined as nonextractable. Various tissues including liver, kidney, fat and lungs contained 8.93% while radioactivity in expired air (14CO2) was low (1.51%). The results indicate that lentil-bound malathion residues are highly bioavailable to rats. Analysis of the lentil material containing bound residues indicated that the main compound was malathion. Lentil-bound malathion residues were administered to albino rats at 0.95 and 6.51 ppm in the feed for 3 months. Body weights were determined during and at the end of the experiment. Terminal organ weights were also determined and a number of blood chemistry parameters were examined. A significant reduction in serum cholinesterase activity and an increase in blood urea nitrogen and in white cell count suggest a toxocological potential of the bound residues.
Akay
M T
MT
Hacettepe University, Science Faculty, Department of Biology, Ankara, Turkey.
Elcüman
A
A
Nurcan
M
M
Kolankaya
D
D
Yilmazoglu
G
G
D000818:Animals; D001682:Biological Availability; D002250:Carbon Radioisotopes; D002802:Cholinesterases / Q000187:drug effects / Q000378:metabolism; D007887:Fabaceae; D005260:Female; D005506:Food Contamination / Q000032:analysis; D005511:Food Handling; D008111:Liver Function Tests; D008294:Malathion / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D010573:Pesticide Residues / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D010946:Plants, Medicinal; D051381:Rats
D002250:Carbon Radioisotopes; D010573:Pesticide Residues; D002802:Cholinesterases; D008294:Malathion