Effect of diet on posttransplant hyperlipidaemia.
Twenty-five patients with a renal transplant for 15 months to 19.4 years, hyperlipidaemia and stable graft function underwent three months of dietary management. Plasma lipid and apolipoprotein concentrations and lipoprotein electrophoresis were measured after a 12 hour fast at enrollment and after three months of diet. The aims of diet were to reduce energy intake in the overweight, restrict fat to 25-30% of total intake, reduce saturated fat content to less than 10% of total energy and cholesterol to less than 300 mg/d. After three months of diet there was a significant fall in mean cholesterol/HDL cholesterol risk ratio and a rise in mean HDL cholesterol concentration. Six patients reverted to a normal lipoprotein electrophoretic pattern with a significant reduction in mean total cholesterol, LDL cholesterol, cholesterol/HDL cholesterol ratio, apoprotein B and apoB/apo A-1 ratio. Most of the other patients who made dietary modifications showed some improvement in their lipid parameters. Dietary modification should be the initial approach to the management of posttransplant hyperlipidaemia.
Divakar
D
D
Department of Nephrology, Christchurch Hospital.
Bailey
R R
RR
Price
M
M
Frampton
C
C
George
P M
PM
D000328:Adult; D000368:Aged; D001797:Blood Protein Electrophoresis; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology; D016030:Kidney Transplantation; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D008074:Lipoproteins; D002784:Cholesterol