title: Treatment of superficial cutaneous pigmented lesions by melanin-specific selective photothermolysis using the Q-switched ruby laser.
abstract: The Q-switched ruby laser at 694 nm, a wavelength well absorbed by melanin relative to other optically absorbing structures in skin, causes highly selective destruction of pigment-laden cells. In addition, the 20-nsec pulse duration produced by this laser approximates the thermal relaxation time for melanosomes, thereby confining the energy to the target. This new laser system produces clinically significant fading of superficial cutaneous pigmented lesions in patients, without complications such as hypertrophic scarring or changes in the normal skin pigmentation, often seen with conventional laser systems or other therapeutic methods. In ongoing clinical trials at our facility, excellent results have been obtained for lentigines, café-au-lait macules, nevus spilus, Becker's nevi, and ephelides (freckles), without skin scarring or textural or permanent pigment changes. The purpose of this report is to (1) describe the theoretical considerations that can be understood and used by a nonlaser-oriented practitioner involved in achieving selective removal of superficial cutaneous pigmented lesions, and (2) describe the practical application of the device to the clinical management of patients.
authors.affiliation: Beckman Laser Institute and Medical Clinic, Irvine, CA 92715.
authors.forename: J S
authors.initials: JS
authors.lastname: Nelson
authors.forename: J
authors.initials: J
authors.lastname: Applebaum
mesh_terms: D005260:Female; D006801:Humans; D053685:Laser Therapy; D007911:Lentigo / Q000532:radiotherapy*; D008297:Male; D008543:Melanins / Q000528:radiation effects; D008544:Melanocytes / Q000528:radiation effects; D008548:Melanosis / Q000532:radiotherapy*; D009508:Nevus, Pigmented / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000532:radiotherapy*
chemical_list: D008543:Melanins