Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on the behavioural satiety sequence.
In rats allowed access to a 35% sucrose solution, following a 4-h period of food and water deprivation, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later superseded by resting. This "behavioural satiety sequence" was advanced in time by the 5-HT uptake inhibitors femoxetine and paroxetine and by the 5-HT1A/B agonist eltoprazine at anorectic and subanorectic doses. These effects, which are similar to those previously observed with another 5-HT uptake inhibitor, fluoxetine, are compatible with an increase in postprandial satiety.
McGuirk
J
J
Psychology Department, City of London Polytechnic, UK.
Muscat
R
R
Willner
P
P
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D017374:Paroxetine; D010879:Piperazines / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012528:Satiety Response / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D010879:Piperazines; D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017374:Paroxetine; C063828:eltoprazine; C010655:femoxetine