Polycystic kidney disease: I. Etiology and pathogenesis.
Geneticists and cell biologists are simultaneously studying the disease's underlying mechanisms. Although a great many questions remain about cyst formation and its role in kidney failure, three fundamental constructs on its etiology and pathogenesis have been generated: renal tubular epithelial proliferation, fluid accumulation, and remodeling of the extracellular matrix.
Grantham
J J
JJ
Department of Medicine, University of Kansas School of Medicine, Kansas City.
D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008967:Molecular Biology; D007690:Polycystic Kidney Diseases / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology