Erythrocyte nucleotides in lead workers.
We determined erythrocyte nucleotides levels in 22 lead workers with blood lead ranging from 8 to 78 micrograms/dl. Their erythrocyte pyrimidine 5'-nucleotidase (P5N) activity ranged from 19.4 to 3.4 mumol uridine/h per g hemoglobin. A significant elevation of erythrocyte pyrimidine nucleotides was found, and their contents correlated inversely with erythrocyte P5N activity and positively with blood lead concentration. In particular, the contents of uridine triphosphate (UTP) and cytidine triphosphate (CTP) exhibited a high correlation with P5N activity (r = -0.56, -0.54). However, its concentration in lead workers was estimated to be much lower than that in hereditary P5N deficiency.
Ichiba
M
M
Department of Community Health Science, Saga Medical School, Japan.
Tomokuni
K
K
Mori
K
K
D015720:5'-Nucleotidase / Q000097:blood*; D000328:Adult; D004912:Erythrocytes / Q000737:chemistry*; D006801:Humans; D007854:Lead / Q000009:adverse effects / Q000097:blood*; D008875:Middle Aged; D009711:Nucleotides / Q000097:blood*; D016273:Occupational Exposure
D009711:Nucleotides; D007854:Lead; D015720:5'-Nucleotidase