[Prednisolone and aspirin therapy for habitual abortion associated with anti-cardiolipin antibody].
Anti-phospholipid antibody syndrome (APS) is characterized by thrombocytopenia, thrombosis and/or abortion. Steroid and aspirin therapy has been reported useful for habitual abortion associated with APS. Eleven patients, whose prior pregnancies resulted in habitual abortion (41 abortions), were received a intentional prednisolone (40 mg/day) and aspirin (81 mg/day) therapy before further pregnancies and both agents were decreased gradually. We maintained prednisolone (10-15 mg/day) and aspirin (40.5 mg/day) during pregnancy period. After the treatment, the outcome of pregnancy was successful in 7 of 10 pregnancies. The weight of newborn infants ranged from 1980 to 2980 g and apgar score ranged from 4 to 9 points. No side effect was observed, and fetal malformation and/or adrenal insufficiency was not recognized in any infants. In conclusion, an intentional prednisolone plus aspirin therapy is useful to prevent habitual abortion in patient with APS.
Yoshida
A
A
Division of Nephrology, Nagoya Second Red Cross Hospital.
Morozumi
K
K
Koyama
K
K
Fukuda
M
M
Oikawa
T
T
D000026:Abortion, Habitual / Q000188:drug therapy* / Q000209:etiology; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000276:immunology; D001241:Aspirin / Q000008:administration & dosage*; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage*; D011247:Pregnancy
D001323:Autoantibodies; D002308:Cardiolipins; D011239:Prednisolone; D001241:Aspirin