[Superior mesenteric arterial infusion chemotherapy in patient with both peritoneal carcinomatosis and liver metastasis].
Experimental study of superior mesenteric arterial infusion chemotherapy was done to evaluate the effect of this therapy on metastatic liver tumor. This treatment has been tried clinically for ileus caused by peritoneal carcinomatosis with good result. Moreover, the infused drug is expected to reach the liver via portal route, just like intraportal administration. This study disclosed that superior mesenteric arterial infusion made for a sufficiently high 5-FU concentration of portal blood but the concentration in the metastatic liver tumor was lower when compared with intravenous infusion. However, because the 5-FU concentration in blood of the aorta was lower than in the intravenous administration group, our method may decrease the unfavorable side effects of anti-cancer drugs.
Ueshima
Y
Y
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Taniguchi
H
H
Miyata
K
K
Suganuma
Y
Y
Takeuchi
K
K
Oguro
A
A
Tsukuda
N
N
Takahashi
T
T
D000818:Animals; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007261:Infusions, Intra-Arterial; D007421:Intestine, Small / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary*; D008638:Mesenteric Arteries; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D011817:Rabbits
D005472:Fluorouracil