[Value of the intestinal permeability test with lactulose-mannitol for screening and monitoring of celiac disease in children].
An intestinal permeability test (IPT) analysing the mannitol (M) and lactulose (L) clearances and the L/M ratios was performed in 15 children followed for celiac disease, before the onset of exclusion diet, during the gluten-free diet and after the reintroduction of gluten. The results showed a significant increase of the L/M ratios under normal diet, with respect to a control population. This increase was related to an increased L urinary excretion and to a decrease in M excretion. During gluten-free diet a normalization of the L/M ratios was observed. Reintroducing gluten altered the L/M ratios by increasing the L intestinal permeability and decreasing the M intestinal permeability. This study shows the value of the non invasive L/M IPT for the screening and monitoring of celiac disease in children.
Leke
L
L
Service de Pédiatrie II, CHRU, Amiens.
Barau
E
E
Barbet
J P
JP
Epelbaum
S
S
Vierin
Y
Y
Dupont
C
C
D002446:Celiac Disease / Q000378:metabolism / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D007792:Lactulose / Q000493:pharmacokinetics*; D008297:Male; D008353:Mannitol / Q000493:pharmacokinetics*; D008403:Mass Screening
D008353:Mannitol; D007792:Lactulose
Intérêt du test de perméabilité intestinale par lactulose-mannitol pour le dépistage et la surveillance de la maladie coeliaque chez l'enfant.