Suramin-induced skin reactions.
METHODS
Suramin sodium, a polysulfonated naphthylurea, has been used for more than 70 years as a chemotherapeutic agent for a variety of diseases. In a phase II trial of suramin, 20 patients with metastatic prostate carcinoma refractory to hormonal manipulation were evaluated retrospectively for evidence of skin toxicity.


RESULTS
Three types of skin reaction were noted: generalized, erythematous, maculopapular eruption (10 patients); keratoacanthoma (two patients); and disseminated superficial actinic porokeratosis (one patient). A total of 15 episodes of some form of skin reaction occurred in 13 patients. The maculopapular eruptions resolved in 3 to 5 days despite continued treatment with suramin.


CONCLUSIONS
Cutaneous toxicity was a frequent and, often, self-limited side effect of suramin therapy, occurring in 13 (65%) patients. Keratoacanthoma and disseminated superficial actinic porokeratosis have not previously been reported to occur with suramin therapy. The immunosuppressive effect of suramin may induce the keratoacanthoma and disseminated superficial actinic porokeratosis lesions.
O'Donnell
B P
BP
Dermatology Service, Walter Reed Army Medical Center, Washington, DC 20307-5001.
Dawson
N A
NA
Weiss
R B
RB
Myers
C E
CE
James
W D
WD
D002277:Carcinoma / Q000150:complications / Q000188:drug therapy; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004341:Drug Evaluation; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D011471:Prostatic Neoplasms / Q000150:complications / Q000188:drug therapy; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013498:Suramin / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
D013498:Suramin