A plan to suppress or prevent the immune rejection of allografted organs.
Progress in the resolution of allograft rejection and associated complications has been hampered by the nonselective nature of current immunosuppressive therapy. In the following protocol, we proposed instead of broadly suppressing immunoreactivity to remove selectively from the bloodstream supplying the transplanted organ only those T lymphocytes and/or antibodies capable of reacting with and destroying the allograft. This goal is to be accomplished by offering them (T cells and/or antibodies) a decoy of antigenically identical tissue. The proposed procedure has the added advantage that it may activate suppressor T cells specific for the allogenic tissue, thereby further promoting acceptance of the graft while providing the host immune system the opportunity to recognize the allograft as autochthonous.
Jacoby
M
M
Department of Chemistry, Eastern Kentucky University, Richmond.
Brock
M
M
D000818:Animals; D001158:Arteries; D046508:Culture Techniques; D006084:Graft Rejection; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D008213:Lymphocyte Activation / Q000276:immunology; D019736:Prostheses and Implants; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014184:Transplantation, Homologous
D006680:HLA Antigens