Differential effects of nifedipine on plasma atrial natriuretic peptide in normal subjects and hypertensive patients.
The physiology of atrial natriuretic peptide (ANP) secretion was studied in normotensive subjects and hypertensive patients both young and old. Basal plasma ANP concentration was least in young normotensives, intermediate in old normotensives and young hypertensives, and highest in old hypertensives. Nifedipine, a known stimulator of ANP secretion, acutely increased plasma ANP in young and old normotensive subjects but not in young hypertensive patients and half of the old hypertensive patients. Increase in serum ANP level in response to nifedipine did not augment its hypotensive effect. However, the increase of aldosterone in response to nifedipine-induced rise in plasma renin activity (PRA) seemed to be suppressed by elevated ANP.
Shigematsu
S
S
Department of Gerontology, Endocrinology, and Metabolism, School of Medicine, Shinshu University, Matsumotoshi, Japan.
Yamada
T
T
Aizawa
T
T
Takasu
N
N
Shimizu
Z
Z
D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D011674:Pulse / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
D009320:Atrial Natriuretic Factor; D009543:Nifedipine