title: [Neonatal cardiac transplantation for hypoplasia of the left heart diagnosed in utero].
abstract: The poor results of palliative surgery in the hypoplastic left heart syndrome has led Bailey to propose neonatal cardiac transplantation for this condition. The authors report the case of a neonate who underwent transplantation 2 days after birth for hypoplastic left heart with mitro-aortic atresia, diagnosed in utero. The child was prescribed triple immunosuppressive therapy (steroids, azathioprine, ciclosporine) and is now 24 months old. An episode of acute rejection during the first month was treated with a short intensive course of intravenous steroids. At the fourth month, the child underwent aortic angioplasty for an isthmic stenosis. Growth is retarded (- 2SD) and he has mild renal failure but psychomotor development has been normal. The number of neonatal cardiac transplantations remains limited by parental refusal and the lack of donor organs. Despite encouraging medium term results, questions remain as to the long-term viability of the graft and the patient's renal function.
authors.affiliation: Service de cardiologie, hôpital cardiovasculaire Louis-Pradel, Lyon.
authors.forename: S
authors.initials: S
authors.lastname: Di Filippo
authors.forename: A
authors.initials: A
authors.lastname: Bozio
authors.forename: F
authors.initials: F
authors.lastname: Sassolas
authors.forename: M
authors.initials: M
authors.lastname: André
authors.forename: J
authors.initials: J
authors.lastname: Ninet
authors.forename: G
authors.initials: G
authors.lastname: Champsaur
authors.forename: J
authors.initials: J
authors.lastname: Normand
authors.forename: D
authors.initials: D
authors.lastname: Jocteur Monrozier
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D005500:Follow-Up Studies; D006084:Graft Rejection; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000601:surgery*; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000002:abnormalities*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D012086:Reoperation; D016216:Ultrasonography, Prenatal
vernacular_title: Transplantation cardiaque néonatale pour hypoplasie du coeur gauche diagnostiquée in utero.