title: [Regulation of the water-electrolyte balance during neurosurgical operations with balanced anesthesia using sodium oxybutyrate].
abstract: Water-electrolyte homeostasis and its basic regulatory hormones have been studied in 36 patients with neurosurgical brain pathology during surgical interventions performed under balanced anesthesia (sodium hydroxybutyrate combined with NLA drugs). The study has revealed 3 types of reactions in hormones regulating water-electrolyte homeostasis: type I--a decrease in vasopressin (VP) concentration and renin-angiotensin-aldosterone system (RAAS) activity; type II--VP increase and RAAS activation; type III--an increase in VP content and RAAS disbalance. It has been shown that type I reaction is accompanied by marked osmotic disturbances. The impact of sodium hydroxybutyrate on RAAS is manifested in aldosterone secretion suppression.
authors.forename: A V
authors.initials: AV
authors.lastname: Gribkov
authors.forename: A P
authors.initials: AP
authors.lastname: Fraerman
authors.forename: V I
authors.initials: VI
authors.lastname: Salalykin
authors.forename: A A
authors.initials: AA
authors.lastname: Salmin
authors.forename: V G
authors.initials: VG
authors.lastname: Sidorkin
authors.forename: E M
authors.initials: EM
authors.lastname: Mikhaĭlova
mesh_terms: D000293:Adolescent; D000328:Adult; D000758:Anesthesia; D001930:Brain Injuries / Q000503:physiopathology / Q000601:surgery*; D001932:Brain Neoplasms / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009458:Neuroleptanalgesia; D012978:Sodium Oxybate; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D012978:Sodium Oxybate
vernacular_title: O reguliatsii vodno-élektrolitnogo obmena pri neĭrokhirurgicheskikh operatsiiakh v usloviiakh sbalansirovannoĭ anestezii oksibutiratom natriia.