title: Refilling the lens with a inflatable endocapsular balloon: surgical procedure in animal eyes.
abstract: In this report we describe the surgical details involved in refilling the lenses of 13 rabbit and 3 primate eyes using an inflatable endocapsular balloon to restore accommodation. The procedure involves endocapsular phacoemulsification through a small "buttonhole" or "dumbbell" anterior capsulotomy or minicircular capsulotomy and the simultaneous preservation of capsular integrity, including the zonules and ciliary muscles. An inflatable balloon made of thin silicone membrane is then inserted into the empty capsular bag. A liquid silicone polymer is injected into the balloon through a delivery tube, and the empty capsular bag is refilled by the inflated balloon. The procedure was found to be reproducible, and an accommodation of 6 D was confirmed in one primate eye. Capsular opacification occurred, but the proliferation and migration of residual lens epithelial cells could be hindered by abundant refilling. This lens-refilling technique may provide restoration of accommodation in future cataract surgery.
authors.affiliation: Nishi Eye Hospital, Osaka, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Nishi
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Sakka
authors.forename: F
authors.initials: F
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Nakamae
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
mesh_terms: D000065:Accommodation, Ocular; D000818:Animals; D002387:Cataract Extraction / Q000379:methods*; D002404:Catheterization; D005500:Follow-Up Studies; D007903:Lens Capsule, Crystalline / Q000473:pathology / Q000601:surgery*; D007910:Lenses, Intraocular; D008251:Macaca; D011817:Rabbits; D012826:Silicone Elastomers
chemical_list: D012826:Silicone Elastomers