Time course of K+ current inhibition by low oxygen in chemoreceptor cells of adult rabbit carotid body. Effects of carbon monoxide.
K+ currents recorded from adult rabbit chemoreceptor cells are reversibly inhibited on lowering the pO2 in the bathing solution. Bath application of a hypoxic TTX-containing solution revealed that inhibition of K+ current by low pO2 proceeds faster than TTX inhibition of Na+ currents, the apparent t1/2 being 3.68 and 7.14 s, respectively. Addition of carbon monoxide to the hypoxic gas mixture used to equilibrate the bathing solution reversed the inhibition of K+ currents by approx. 70%.
López-López
J R
JR
Departamento de Bioquímica y Biología Molecular y Fisiologia, Facultad de Medicina, Universidad de Valladolid, Spain.
González
C
C
D000818:Animals; D002248:Carbon Monoxide / Q000378:metabolism; D002344:Carotid Body / Q000502:physiology*; D002478:Cells, Cultured; D000860:Hypoxia; D008564:Membrane Potentials / Q000502:physiology*; D011188:Potassium / Q000378:metabolism*; D011817:Rabbits; D012964:Sodium / Q000378:metabolism
D002248:Carbon Monoxide; D012964:Sodium; D011188:Potassium