A biological basis for re-stenosis after percutaneous transluminal angioplasty: possible underlying mechanisms.
Intravascular catheterization is a commonly used diagnostic tool and percutaneous transluminal angioplasty is used to dilate stenosed blood vessels. Although these techniques are very successful diagnostically and therapeutically they may precipitate a number of acute and chronic complications. Chronic intimal changes following balloon angioplasty can result in re-stenosis. Intimal hyperplasia can be a long-term complication of both diagnostic and interventional vascular catheterization. This article details these long-term structural changes, specifically relating experimental in vivo and in vitro changes to those seen clinically.
Tennant
M
M
Department of Anatomy and Human Biology, University of Western Australia, Nedlands.
McGeachie
J K
JK
D000800:Angioplasty, Balloon / Q000009:adverse effects*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D001157:Arterial Occlusive Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D003327:Coronary Disease / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000293:injuries / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D009131:Muscle, Smooth, Vascular / Q000293:injuries / Q000473:pathology; D012008:Recurrence