Promotability and tissue specificity of hereditary cancer genes: do hereditary cancer patients have a reduced requirement for tumor promotion because all their somatic cells are heterozygous at the predisposing locus?
Paraskeva
C
C
Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, United Kingdom.
Williams
A C
AC
D000236:Adenoma / Q000235:genetics; D000818:Animals; D002273:Carcinogens; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000502:physiology; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D002273:Carcinogens; D016159:Tumor Suppressor Protein p53