Analysis of Leptospira spp., Leptonema illini, and Rickettsia rickettsii for the 39-kilodalton antigen (P39) of Borrelia burgdorferi.
Five serovars of Leptospira interrogans, Leptospira biflexa, Leptonema illini, and Rickettsia rickettsii were examined and found not to contain the 39-kDa antigen (P39) of Borrelia burgdorferi, the Lyme disease spirochete. The specificity of this antigen and its reactivity with human Lyme disease sera should exclude the possibility of false-positive serum samples from patients having had either leptospirosis or Rocky Mountain spotted fever, as well as tick-borne relapsing fever and syphilis, as reported previously (W.J. Simpson, M. E. Schrumpf, and T. G. Schwan, J. Clin. Microbiol. 28:1329-1337, 1990).
Schwan
T G
TG
Arthropod-Borne Diseases Section, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840.
Schrumpf
M E
ME
Gage
K L
KL
Gilmore
R D
RD
D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000032:analysis* / Q000737:chemistry; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D003429:Cross Reactions; D005189:False Positive Reactions; D006801:Humans; D007919:Leptospira / Q000276:immunology; D008193:Lyme Disease / Q000175:diagnosis / Q000276:immunology; D008970:Molecular Weight; D012284:Rickettsia rickettsii / Q000276:immunology; D012698:Serologic Tests; D013045:Species Specificity
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial