Novel, quinone-thiosemicarbazone hybrid (QTSCHY) non-platinum antitumor agents: inhibition of DNA biosynthesis in P388 lymphocytic cells by coordinatively unsaturated copper(II) and iron(III) complexes of naphthoquinone thiosemicarbazones.
Coordinately unsaturated Cu(II) and Fe(III) complexes of the stoichiometry [Cu(L)Cl] and [Fe(L)Cl2], where L = tridentate anion of 2-hydroxy-1,4-naphthoquinone 1-thiosemicarbazone (2HNQTSC) and its 3-methyl derivative (3M2HNQTSC), were screened in vitro against P388 lymphocytic leukemia cells. Copper complexes were found to be more effective inhibitors of DNA synthesis than analogous Fe(III) compounds. The inhibitory activities are suggested to be related to Cu(II)-Cu(I) redox couple or nitrogen adduct formation.
Padhye
S
S
Department of Botany, Arizona State University, Tempe 85287-1601.
Chikate
R
R
Kumbhar
A
A
Shallom
J M
JM
Chitnis
M P
MP
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002614:Chelating Agents / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007941:Leukemia P388 / Q000188:drug therapy; D008214:Lymphocytes; D051379:Mice; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002614:Chelating Agents; D007502:Iron Chelating Agents; D009285:Naphthoquinones; D013882:Thiosemicarbazones; D003300:Copper; D004247:DNA