Glutathione adduct of hemoglobin (Hb ASSG) in hemolysates of patients on long-term antiepileptic therapy.
1. A novel, hitherto unrecognized, hemoglobin fraction, HbA1x, has been detected in amounts up to 7% of the total Hb, in hemolysates from epileptic patients with long-term therapy containing phenobarbital (PB) and carbamazepine (Carb). 2. HbA1x was shown to represent glutathione adduct of Hb (Hb ASSG). 3. To our knowledge, this is the first demonstration of the occurrence of Hb ASSG in vivo.
Niketić
V
V
Department of Chemistry, Faculty of Science, University of Belgrade, Yugoslavia.
Beslo
D
D
Raicević
S
S
Sredić
S
S
Stojković
M
M
D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007525:Isoelectric Focusing; D007526:Isoelectric Point; D008297:Male; D008706:Methemoglobin / Q000378:metabolism; D010634:Phenobarbital / Q000009:adverse effects* / Q000627:therapeutic use; D013438:Sulfhydryl Compounds / Q000097:blood
D002220:Carbamazepine; D005978:Glutathione; D006442:Glycated Hemoglobin; D008706:Methemoglobin; D010634:Phenobarbital; D013438:Sulfhydryl Compounds