title: Postmenopausal hyperandrogenism of ovarian origin. A clinicopathologic study of four cases.
abstract: Postmenopausal hyperandrogenism with overt clinical effects is rare and often related to ovarian stromal disorders. We present a clinicopathologic study of 4 cases. The patients (age range 41-75 years; mean 62 years) had evidence of hirsutism or frank virilization. Their serum testosterone was elevated with or without increases in their serum androstenedione and DHEA levels. There were two right-ovarian hilus cell tumors, one associated with left-ovarian stromal hyperplasia and the other with bilateral hyperthecosis and nodular hilus cell hyperplasia. The other tumor was a small corticomedullary stromal luteoma with bilateral hyperthecosis and nodular hilus cell hyperplasia. The fourth patient had bilateral hilus cell hyperplasia with mild cortical-stromal hyperplasia. All these patients had rapid normalization of androgen levels after surgery without recurrence after a 2- to 10-year follow-up.
authors.affiliation: Department of Pathology, University of Alberta, Edmonton, Canada.
authors.forename: L H
authors.initials: LH
authors.lastname: Honoré
authors.forename: R
authors.initials: R
authors.lastname: Chari
authors.forename: H D
authors.initials: HD
authors.lastname: Mueller
authors.forename: D C
authors.initials: DC
authors.lastname: Cumming
authors.forename: J Z
authors.initials: JZ
authors.lastname: Scott
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007984:Leydig Cell Tumor / Q000150:complications / Q000473:pathology; D008297:Male; D008593:Menopause; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology*; D010053:Ovary / Q000473:pathology; D013739:Testosterone / Q000097:blood; D014770:Virilism / Q000209:etiology*
chemical_list: D013739:Testosterone