A protein expressed in the growth cones of embryonic vertebrate neurons defines a new class of intermediate filament protein.
We have isolated and characterized cDNAs that encode a protein expressed in the axons and growth cones of a subset of Xenopus embryonic neurons. The protein is also expressed in a subset of cells of the brain, including cells in even-numbered rhombomeres, the eye, and the heart. The sequence of the cDNA suggests that the protein belongs to a new class of neural-specific intermediate filaments. Both the RNA and the protein are expressed in the neurula and persist during embryogenesis in the brain, cranial nerves, and spinal cord. Because of the predicted structure of the protein, we have named it tanabin (from the Persian word for rope).
Hemmati-Brivanlou
A
A
Department of Molecular and Cellular Biology, University of California, Berkeley 94720.
Mann
R W
RW
Harland
R M
RM
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000302:isolation & purification; D001369:Axons / Q000378:metabolism; D001483:Base Sequence; D003001:Cloning, Molecular; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D007301:Insect Hormones / Q000276:immunology / Q000378:metabolism; D007381:Intermediate Filament Proteins / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000276:immunology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011956:Receptors, Cell Surface; D014018:Tissue Distribution; D051193:Toll-Like Receptors; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology*
D000906:Antibodies; D029721:Drosophila Proteins; D007301:Insect Hormones; D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; D029867:Xenopus Proteins; C076638:NES protein, Xenopus