title: Continuous infusion of intrathecal morphine to control acquired immunodeficiency syndrome-associated bladder pain.
abstract: A 36-year-old man with acquired immunodeficiency syndrome had incapacitating dysuria and vesical pain secondary to interstitial cystitis. When medical management and suprapubic urinary diversion failed to control the symptoms the patient was started on subarachnoid morphine sulfate. Bupivacaine was added 1 year later via an implanted Therex M-3000 implantable continuous infusion pump, which has continued successfully for more than 18 months. We believe that subarachnoid narcotics and other analgesic agents, such as clonidine, bupivacaine hydrochloride and baclofen, may prove equally valuable in the treatment of bladder spasm and pain. Furthermore, implanted intrathecal ports and pumps may have less associated risk of infection than the percutaneous vascular access catheters presently used for the continuous delivery of medications in immunosuppressed patients.
authors.affiliation: Department of Surgery, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire 03756.
authors.forename: E
authors.initials: E
authors.lastname: Jonsson
authors.forename: D W
authors.initials: DW
authors.lastname: Coombs
authors.forename: D
authors.initials: D
authors.lastname: Hunstad
authors.forename: J R
authors.initials: JR
authors.lastname: Richardson
authors.forename: C F
authors.initials: CF
authors.lastname: von Reyn
authors.forename: R L
authors.initials: RL
authors.lastname: Saunders
authors.forename: J A
authors.initials: JA
authors.lastname: Heaney
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000150:complications / Q000188:drug therapy*; D001745:Urinary Bladder Diseases / Q000150:complications / Q000188:drug therapy*
chemical_list: D009020:Morphine