Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum.
Human tissue inhibitor of metalloproteinases-1 (TIMP-1), but not TIMP-2, has potent growth-promoting activity for a wide range of human and bovine cells. TIMP-1 seems to be a new cell-growth factor in serum and to stimulate the cells independently of its inhibitory activity.
Hayakawa
T
T
Department of Biochemistry, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Yamashita
K
K
Tanzawa
K
K
Uchijima
E
E
Iwata
K
K
D000818:Animals; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005881:Gingiva / Q000187:drug effects / Q000254:growth & development; D006023:Glycoproteins / Q000502:physiology*; D006133:Growth Substances / Q000097:blood* / Q000502:physiology; D006801:Humans; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors*; D009363:Neoplasm Proteins / Q000502:physiology; D019716:Tissue Inhibitor of Metalloproteinase-2; D019714:Tissue Inhibitor of Metalloproteinases; D014407:Tumor Cells, Cultured
D006023:Glycoproteins; D006133:Growth Substances; D009363:Neoplasm Proteins; D019714:Tissue Inhibitor of Metalloproteinases; D019716:Tissue Inhibitor of Metalloproteinase-2; D008666:Metalloendopeptidases