Selected pharmacologic characteristics of idarubicin and idarubicinol.
The pharmacology of ID and IDOL are of interest in light of the potential utility of ID in the treatment of adult and pediatric leukemia patients. Preclinical activity and cellular pharmacology of ID were suggestive of greater clinical activity when compared with several standard anthracyclines. Most intriguing were data comparing in vitro and in vivo activity data and cellular pharmacology of IDOL to other anthracycline alcohol metabolites. Given the pharmacokinetics of IDOL, there is continued interest in the unique aspects of IDOL pharmacology as an important element of ID pharmacology.
Ames
M M
MM
Department of Oncology, Mayo Clinic, Rochester, MN.
Spreafico
F
F
D000818:Animals; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D015255:Idarubicin / Q000494:pharmacology*
C054440:idarubicinol; D015255:Idarubicin; D003630:Daunorubicin