Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis.
The anti-phlogistic effect of dietary vitamin E supplementation on the acute inflammation observed in experimental lens-induced uveitis in Brown Norway rats was studied. The effects of vitamin E were examined using histopathologic parameters as well as by measuring the levels of arachidonic acid metabolites. Histologic examination of the eyes revealed that the vitamin E-deficient animals had the most severe destruction of the retina, while those animals receiving the vitamin E-supplemented diet exhibited the best preservation of the retinal architecture. Levels of arachidonic acid metabolites, as determined by radioimmunoassay, were significantly higher in vitamin E deficient rats as compared with rats on a normal diet.
Cid
L
L
Doheny Eye Institute, Los Angeles, CA.
Pararajasegaram
G
G
Sevanian
A
A
Gauderman
W
W
Romero
J L
JL
Marak
G E
GE
Rao
N A
NA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000032:analysis; D002829:Choroid / Q000737:chemistry / Q000473:pathology; D003459:Crystallins / Q000032:analysis; D005260:Female; D011863:Radioimmunoassay; D051381:Rats; D011914:Rats, Inbred BN; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003459:Crystallins; D014810:Vitamin E; D016718:Arachidonic Acid