title: Importance of left ventricular function and systolic ventricular interaction to right ventricular performance during acute right heart ischemia.
abstract: To determine whether modulation of systolic ventricular interaction influences right ventricular performance during right heart ischemia, the effects of septal ischemia and inotropic stimulation were studied in 15 dogs in an open chest preparation. Right coronary branch occlusions led to right ventricular dilation and free wall dyskinesia, reversed septal curvature and reduced left ventricular diastolic volume. In systole, the septum thickened but bulged paradoxically into the right ventricle generating an active but depressed right ventricular systolic pressure (28.9 +/- 5.5 to 22.1 +/- 4.5 mm Hg), with associated decreases in right ventricular stroke work (5.66 +/- 0.94 to 1.92 +/- 0.53 g.m/m2) and left ventricular systolic pressure (123 +/- 11 to 80 +/- 10 mm Hg). Septal ischemia induced systolic septal thinning, left ventricular dilation and decreased left ventricular systolic pressure (80 +/- 10 to 55 +/- 10 mm Hg) and stroke work. Although the extent of paradoxic septal displacement increased, there were further decrements in right ventricular systolic pressure (22.1 +/- 4.5 to 18.7 +/- 4.3 mm Hg) and stroke work (1.92 +/- 0.53 to 0.7 +/- 0.2 g.m/m2). Dopamine infusion augmented left ventricular free wall contraction and increased left ventricular systolic pressure (55 +/- 10 to 172 +/- 17 mm Hg) and stroke work. Although systolic septal thinning persisted, the extent of paradoxic septal displacement increased strikingly and, despite continued right ventricular free wall dyskinesia, right ventricular systolic pressure increased (18.7 +/- 4.3 to 39.6 +/- 6.2 mm Hg) as did right ventricular stroke work (0.7 +/- 0.2 to 7 +/- 1.6 g.m/m2).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110.
authors.forename: J A
authors.initials: JA
authors.lastname: Goldstein
authors.forename: J S
authors.initials: JS
authors.lastname: Tweddell
authors.forename: B
authors.initials: B
authors.lastname: Barzilai
authors.forename: Y
authors.initials: Y
authors.lastname: Yagi
authors.forename: A S
authors.initials: AS
authors.lastname: Jaffe
authors.forename: J L
authors.initials: JL
authors.lastname: Cox
mesh_terms: D000208:Acute Disease; D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D004452:Echocardiography; D006346:Heart Septum / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D009203:Myocardial Infarction / Q000503:physiopathology; D013599:Systole / Q000502:physiology*; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology*; D016278:Ventricular Function, Right / Q000187:drug effects / Q000502:physiology*
chemical_list: D004298:Dopamine