title: Irradiation-induced atherosclerosis: a factor in therapeutic planning.
abstract: Early primary head and neck cancers (stages I and II) and occult metastatic neck disease have caused debate regarding the choice between surgery and irradiation. The arguments for each are reviewed with a new consideration: the acceleration and/or induction of carotid atherosclerosis in irradiated patients. We present clinical case reports (n = 9), a retrospective clinical evaluation for the occurrence of carotid atherosclerosis in irradiated head and neck cancer patients (n = 57) and a comparison study of the extent and distribution of atherosclerosis in irradiated (n = 29) and nonirradiated head and neck cancer patients controlled for age, blood pressure, and tobacco use. The results show that carotid atherosclerosis is found in a wider anatomic distribution and to a greater extent in irradiated than in nonirradiated patients. We conclude that carotid atherosclerosis is induced and/or accelerated by neck irradiation. The implications as they relate to choice of treatment, to pretreatment evaluations, and to long-term follow-up are discussed.
authors.affiliation: Department of Otolaryngology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157.
authors.forename: W F
authors.initials: WF
authors.lastname: McGuirt
authors.forename: R S
authors.initials: RS
authors.lastname: Feehs
authors.forename: G
authors.initials: G
authors.lastname: Bond
authors.forename: J L
authors.initials: JL
authors.lastname: Strickland
authors.forename: W M
authors.initials: WM
authors.lastname: McKinney
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000209:etiology*; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000528:radiation effects; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging / Q000528:radiation effects; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D014463:Ultrasonography