title: Right ventricular overload and induced sustained ventricular tachycardia in operatively "repaired" tetralogy of Fallot.
abstract: The aim of the study was to evaluate the main predictors of the inducibility of sustained ventricular tachycardia (VT) in patients with repaired tetralogy of Fallot. Thirty-five patients (age 12 +/- 6 years) underwent right-sided cardiac catheterization, echocardiography, radionuclide angiography and ventricular stimulation; 10 had (group 1) and 25 had no (group 2) sustained VT. Group 1 patients were significantly older at the time of surgery and had longer follow-up periods (7 +/- 3 vs 4 +/- 4 years, p less than 0.02; and 12 +/- 4 vs 5 +/- 2 years, p less than 0.001, respectively). Right ventricular (RV) systolic pressure, end-systolic and end-diastolic normalized RV volumes were higher in group 1 (48 +/- 14 vs 38 +/- 11 mm Hg, p less than 0.05; 1.23 +/- 0.2 vs 0.86 +/- 0.17, p less than 0.001; and 2.35 +/- 0.37 vs 1.70 +/- 0.22, p less than 0.001, respectively). RV end-diastolic pressure, left ventricular and RV ejection fractions were similar in the 2 groups. A stepwise discriminant analysis was made to predict patients with inducible sustained VT (group 1): Time period from surgery to follow-up (p less than 0.001), normalized RV end-systolic volume (p less than 0.002) and RV systolic pressure (p = 0.01) were higher in group 1 and allowed classification of 90% of patients in group 1 and 96% in group 2.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiology, CHRU Nancy, France.
authors.forename: P Y
authors.initials: PY
authors.lastname: Marie
authors.forename: F
authors.initials: F
authors.lastname: Marçon
authors.forename: F
authors.initials: F
authors.lastname: Brunotte
authors.forename: S
authors.initials: S
authors.lastname: Briançon
authors.forename: N
authors.initials: N
authors.lastname: Danchin
authors.forename: A M
authors.initials: AM
authors.lastname: Worms
authors.forename: J
authors.initials: J
authors.lastname: Robert
authors.forename: C
authors.initials: C
authors.lastname: Pernot
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D015635:Radionuclide Ventriculography; D013610:Tachycardia / Q000209:etiology* / Q000503:physiopathology; D013771:Tetralogy of Fallot / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right