2-Amino-2-oxazolines, V: Synthesis of some 5-dialkylaminomethyl-2-amino-2-oxazolines and evaluation of their diuretic activity.
A series of 5-dialkylaminomethyl-2-amino-2-oxazolines was prepared and screened for diuretic activity. These compounds were previously examined for their lipophilic behaviour using a reversed-phase HPLC technique. The capacity factors, expressed as log k'w, were correlated with the partition coefficient log P. A QSAR analysis of the diuretic activity in relation with the lipophilicity was attempted for these structurally related compounds.
Demotes-Mainard
F
F
Laboratoire de Pharmacologie, Université de Bordeaux II, France.
Tranchot
J
J
Cambar
J
J
Jarry
C
C
D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004232:Diuretics; D010080:Oxazoles