Pharmacokinetics and pharmacodynamics of levodopa.
Levodopa is effective in relieving symptoms of Parkinson's disease. However, long-term complications make sustained control problematic. Most management problems are related to the pharmacokinetic and pharmacodynamic properties of levodopa. Careful titration based on pharmacologic principles may achieve optimal therapeutic effects.
Montgomery
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Department of Neurology, University of Arizona College of Medicine, Arizona Health Sciences Center, Tucson 85724.
D000284:Administration, Oral; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000378:metabolism; D001769:Blood / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004409:Dyskinesia, Drug-Induced / Q000145:classification; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000378:metabolism
D011954:Receptors, Dopamine; D007980:Levodopa; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine