Virus infections of the respiratory tract in HIV-infected children.
In order to determine whether the rates of respiratory viral infection and the severity of respiratory symptoms in HIV-infected children were higher than those in noninfected children, nose and throat swabs for viral isolation were taken at 3-month intervals during the first 2 years of life from 50 children born to HIV-infected women. Similar samples were obtained during the first year of life from 19 control children born to HIV seronegative mothers. Of the 50 children, five proved to be HIV-infected while 45 were presumed to be uninfected. HIV-infected children had significantly more respiratory symptoms and a higher proportion of samples from which viruses were isolated than the non-HIV-infected children. Also, more infected episodes required admission to hospital in the HIV-infected group. There was no such difference between the non-HIV-infected and the control children. Three HIV-infected children received intravenous immunoglobulin therapy. Among these the proportion of positive samples for viral isolation was greater before than after treatment began. These results suggest that HIV-infected children are more susceptible to recurrent viral infection and that passive immunotherapy may be of benefit to such children.
Hague
R A
RA
Infectious Diseases Unit, City Hospital, Edinburgh, Scotland, U.K.
Burns
S E
SE
Hargreaves
F D
FD
Mok
J Y
JY
Yap
P L
PL
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D002675:Child, Preschool; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D007231:Infant, Newborn; D011446:Prospective Studies; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology* / Q000628:therapy; D012606:Scotland / Q000453:epidemiology; D012959:Socioeconomic Factors; D014773:Virology / Q000379:methods; D014777:Virus Diseases / Q000453:epidemiology / Q000382:microbiology* / Q000628:therapy
D016756:Immunoglobulins, Intravenous