An analysis of the 1987 list of IARC-identified human carcinogens and the correlated animal studies.
The thesis that the use of long-term, appropriately conducted and interpreted laboratory studies with rats and/or mice to test materials for potential carcinogenicity in humans is supported by the evidence on human carcinogens developed by Working Groups of the International Agency for Research on Cancer (IARC) is examined by a review of the Working Group reports on IARC-designated human carcinogens. The conclusion from that review is that the list of carcinogens does not constitute a sufficiently diverse group of agents to warrant a generalization; nor do the correlated animal studies justify the implied claim that most human carcinogens are demonstrated animal carcinogens, when the test for animal carcinogenicity is a properly conducted and interpreted study with rats and/or mice.
Stoloff
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D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D006801:Humans; D051379:Mice; D009784:Occupational Diseases / Q000139:chemically induced; D051381:Rats; D012306:Risk; D013045:Species Specificity
D002273:Carcinogens