title: Effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites.
abstract: The effects of dextropropoxyphene on the steady-state kinetics of oxcarbazepine and its metabolites were investigated in eight patients with epilepsy or trigeminal neuralgia. One patient dropped out of the study, presumably due to side-effects of dextropropoxyphene. Dextropropoxyphene did not affect the plasma levels of the principal active metabolite, 10,11-dihydro-10-hydroxy-carbamazepine. Since dextropropoxyphene is known to increase the plasma levels of carbamazepine, leading to toxicity, the findings of this study suggest that oxcarbazepine is a useful alternative to carbamazepine when concomitant dextropropoxyphene therapy is required.
authors.affiliation: University Neurology Clinic, Hvidovre Hospital, Denmark.
authors.forename: P H
authors.initials: PH
authors.lastname: Mogensen
authors.forename: L
authors.initials: L
authors.lastname: Jórgensen
authors.forename: J
authors.initials: J
authors.lastname: Boas
authors.forename: M
authors.initials: M
authors.lastname: Dam
authors.forename: A
authors.initials: A
authors.lastname: Vesterager
authors.forename: G
authors.initials: G
authors.lastname: Flesch
authors.forename: P K
authors.initials: PK
authors.lastname: Jensen
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D002220:Carbamazepine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011431:Dextropropoxyphene / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000078330:Oxcarbazepine; D014277:Trigeminal Neuralgia / Q000097:blood* / Q000188:drug therapy*
chemical_list: C039775:10,11-dihydro-10-hydroxycarbamazepine; D000927:Anticonvulsants; D002220:Carbamazepine; C004822:10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide; D011431:Dextropropoxyphene; D000078330:Oxcarbazepine