title: A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia.
abstract: A total of 149 patients in 7 centers in Denmark, Norway and Sweden entered a 6-week double-blind trial intended to assess the antidepressant effect and safety of citalopram vs placebo in depressed elderly patients (65 years of age or older) who might also suffer from somatic disorders and/or senile dementia. Results of ratings on the Hamilton Rating Scale for Depression, the Montgomery-Asberg Depression Rating Scale and the Clinical Global Impression Scale provided consistent evidence that the citalopram-treated patients improved more than the placebo-treated patients. Results of ratings on the Gottfries-Bråne-Steen dementia rating scale indicated that both cognitive and emotional functioning improved significantly more in the citalopram-treated subgroup of patients with dementia than in the placebo-treated subgroup.
authors.affiliation: Department of Psychiatry and Neurochemistry, University of Göteborg, Mölndal Hospital, Sweden.
authors.forename: A L
authors.initials: AL
authors.lastname: Nyth
authors.forename: C G
authors.initials: CG
authors.lastname: Gottfries
authors.forename: K
authors.initials: K
authors.lastname: Lyby
authors.forename: L
authors.initials: L
authors.lastname: Smedegaard-Andersen
authors.forename: J
authors.initials: J
authors.lastname: Gylding-Sabroe
authors.forename: M
authors.initials: M
authors.lastname: Kristensen
authors.forename: H E
authors.initials: HE
authors.lastname: Refsum
authors.forename: E
authors.initials: E
authors.lastname: Ofsti
authors.forename: S
authors.initials: S
authors.lastname: Eriksson
authors.forename: S
authors.initials: S
authors.lastname: Syversen
mesh_terms: D000368:Aged; D015283:Citalopram / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects; D003704:Dementia / Q000523:psychology*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D006801:Humans; D010919:Placebos
chemical_list: D010919:Placebos; D015283:Citalopram