title: Photosensitization caused by ibuprofen.
abstract: Several nonsteroid antiinflammatory drugs (e.g., benoxaprofen, carprofen, and piroxicam) are known to induce photosensitivity reactions, but this has not yet been documented for ibuprofen. We observed a photosensitivity reaction in a patient treated with an oral ibuprofen preparation. This patient had a lowered minimal erythema dose for UVA but not for UVB after oral administration of ibuprofen. Results of a photopatch test with the drug were negative. In vitro UVA irradiation of human erythrocytes in the presence of ibuprofen caused ultraviolet dose-dependent phototoxic hemolysis.
authors.affiliation: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Federal Republic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Bergner
authors.forename: B
authors.initials: B
authors.lastname: Przybilla
mesh_terms: D000328:Adult; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D007052:Ibuprofen