[Primary effect of preoperative intra-arterial infusion chemotherapy in cervical cancer].
In order to obtain better prognoses for cervical cancer, we conducted preoperative intra-arterial (i.a.) infusion chemotherapy of CDDP in combination with AT-II pressor. Two courses of i.a. chemotherapy were performed for 67 patients with cervical cancer in stage IIb containing 54 squamous cell carcinomas and 13 adenocarcinomas before operation every 3 weeks. A histologically desirable effect in cervical lesion was obtained. A group given preoperative i.a. chemotherapy had a significantly lower rate of infiltration beyond uterus in comparison with 156 patients with 145 squamous cell carcinomas and 11 adenocarcinomas treated by surgery alone as the control group. Further, the rate of histological infiltration to parametrial edges after i.a. chemotherapy tended to be lower than the control group. From the above, it was considered that preoperative i.a. infusion chemotherapy of CDDP in combination with AT-II pressor for cervical cancer was effective as a neo-adjuvant chemotherapy.
Kondoh
T
T
Dept. of Obstetrics and Gynecology, Okayama University School of Medicine.
Nakagiri
Y
Y
Hongoh
A
A
Handa
M
M
Yuasa
T
T
Ohmura
Y
Y
Sanoh
T
T
Okuda
H
H
Kudoh
T
T
Sekiba
K
K
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000804:Angiotensin II / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011300:Preoperative Care; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000804:Angiotensin II; D002945:Cisplatin