[Immunohistochemistry of the Scarpa's ganglion and the crista ampullaris of patients with Menière disease].
In certain long-lasting cases of Menière's disease with recurrent attacks, despite of saccotomy, the removal of the vestibular ganglion is the only procedure that relieves vertigo. During ganglionectomy of this group of patients all fresh tissues gotten and gathered from operation are frozen immediately and preserved for immunohistochemical assay with direct and indirect incubations. The positive findings such as ASMA+, AEA+ and ANA+ in tissues of patient's own as well as in control tissues further confirmed the results previously reported by us. The immune-complex mediated arteriolar and capillary vasculitis on the basis of an autoimmune disorder as a secondary autoimmune marker might play a dominant role in this patients group. The demyelination of vestibular neurons in the Ganglion Scarpae might be the cause of the Menière symptoms. To confirming the hypothesis, the research plan must be continuously carried out.
Wei
N R
NR
Universitäts-HNO-Klinik Tübingen.
Giebel
W
W
Helms
J
J
D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D003711:Demyelinating Diseases / Q000276:immunology / Q000473:pathology; D004730:Endothelium, Vascular / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D008575:Meniere Disease / Q000276:immunology / Q000473:pathology*; D009130:Muscle, Smooth / Q000276:immunology; D012665:Semicircular Canals / Q000276:immunology / Q000473:pathology*; D014725:Vestibular Nerve / Q000276:immunology / Q000473:pathology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies
Immunohistochemie am Ganglion scarpae und an der Crista ampullaris von Menière-Patienten.