Blood transfusions in the therapy of a case of prolidase deficiency.
A case is reported of a 15-year-old boy with prolidase deficiency and marked urinary excretion of the iminodipeptide gly-pro. Prolidase activity of erythrocytes against substrate glycyl-proline was deficient, but after blood transfusions this was increased to 15.7% of donor activity and declined to 12% and 3.4% of normal activity after 8 and 45 days, respectively. Urinary iminodipeptide levels following transfusion remained unaltered.
Berardesca
E
E
Department of Dermatology, IRCCS Policlinico San Matteo, Italy.
Fideli
D
D
Bellosta
M
M
Dyne
K M
KM
Zanaboni
G
G
Cetta
G
G
D000293:Adolescent; D016913:Blood Component Transfusion; D004150:Dipeptidases / Q000172:deficiency*; D004151:Dipeptides / Q000652:urine*; D016523:Foot Ulcer / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008297:Male
D004151:Dipeptides; C015248:glycylproline; D004150:Dipeptidases; C022449:proline dipeptidase