title: The human ribonuclease/angiogenin inhibitor is encoded by a gene mapped to chromosome 11p15.5, within 90 kb of the HRAS protooncogene.
abstract: Ribonuclease/angiogenin inhibitor (RAI) is a tight-binding inhibitor of ribonucleolytic and angiogenic activities involved in tumor progression. It is translated from various mRNAs differing in their 5 regions and originating from a single gene locus. Recently, this gene (RNH) has been assigned to 11p15.5, the terminal part of the short arm of chromosome 11. The regional chromosomal localization was confirmed by somatic cell and in situ hybridization and further refined by long-range restriction mapping. The data place RNH within 90 kb of the Harvey-ras protooncogene (HRAS), so far the most telomeric gene on 11p, in a region involved in growth regulation and tumor development.
authors.affiliation: Institut für Biochemie, Universität Innsbruck, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Schneider
authors.forename: M J
authors.initials: MJ
authors.lastname: Higgins
authors.forename: D
authors.initials: D
authors.lastname: Kieninger
authors.forename: E
authors.initials: E
authors.lastname: Schneider-Scherzer
authors.forename: M
authors.initials: M
authors.lastname: Hirsch-Kauffmann
authors.forename: M
authors.initials: M
authors.lastname: Schweiger
authors.forename: R L
authors.initials: RL
authors.lastname: Eddy
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: B U
authors.initials: BU
authors.lastname: Zabel
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D011506:Proteins / Q000037:antagonists & inhibitors*; D015183:Restriction Mapping; D012259:Ribonuclease, Pancreatic; D012260:Ribonucleases / Q000037:antagonists & inhibitors*
chemical_list: D011506:Proteins; D012260:Ribonucleases; C046366:angiogenin; D012259:Ribonuclease, Pancreatic