title: Effects of exsanguination and sodium nitroprusside on compliance of the spinal canal during aortic occlusion.
abstract: To evaluate the effects of sodium nitroprusside (SNP) and partial exsanguination (EXS) on systemic hemodynamics and cerebrospinal fluid dynamics, we monitored proximal and distal blood pressure (BP), cerebrospinal fluid pressure (CSFP), spinal cord perfusion pressure (SCPP), and compliance of the spinal canal (CSC) in 10 mongrel dogs during aortic cross-clamping of the descending thoracic aorta. CSC was measured by serial injections of 2 ml of saline solution into the cisterna cerebellomedullaris via a percutaneously placed catheter with simultaneous measurements of CSFP. Data were acquired at baseline (BL), during aortic cross-clamping with proximal hypertension (AXC), and after control of proximal hypertension with EXS and SNP. During the cross-clamp interval, mean proximal aortic pressure (PxBP) rose from 114 +/- 6 to 150 +/- 3 mm Hg (P less than 0.001), whereas mean blood pressure decreased to 88 +/- 5 and 82 +/- 4 mm Hg during the SNP and EXS intervals, respectively (P less than 0.05 vs BL). EXS and SNP were equally effective in controlling PxBP (82 +/- 4 vs 88 +/- 5 mm Hg, P greater than 0.05). Mean distal aortic pressure (DsBP) decreased from systemic values to 21.5 +/- 1.9 mm Hg during AXC, and to 12.4 +/- 1.0 and to 8 +/- 0.8 mm Hg during EXS and SNP, respectively (P less than 0.05 AXC vs EXS and SNP). SNP lowered DsBP significantly more than EXS, 8 +/- 0.8 vs 12.4 +/- 1.0 mm Hg (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Surgery, SUNY Health Science Center, Brooklyn, New York.
authors.forename: R E
authors.initials: RE
authors.lastname: Maughan
authors.forename: C
authors.initials: C
authors.lastname: Mohan
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.forename: J N
authors.initials: JN
authors.lastname: Cunningham
authors.forename: I
authors.initials: I
authors.lastname: Jacobowitz
authors.forename: C P
authors.initials: CP
authors.lastname: Marini
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery*; D001810:Blood Volume; D015170:Cerebrospinal Fluid Pressure; D003187:Compliance; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D009599:Nitroprusside / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control; D013115:Spinal Canal / Q000502:physiology*; D013116:Spinal Cord / Q000098:blood supply*
chemical_list: D009599:Nitroprusside