Low-dose pimozide augmentation of serotonin reuptake blockers in the treatment of trichotillomania.
BACKGROUND
There is some overlap in the phenomenology and treatment response of trichotillomania, Gilles de la Tourette's syndrome (TS), and obsessive compulsive disorder (OCD). Neuroleptics may play a role in the treatment of TS as well as refractory OCD, and the question arises whether this also holds for trichotillomania.


METHODS
Patients with trichotillomania were treated in open clinical practice with serotonin reuptake blockers. When symptom resolution was incomplete or symptom relapse occurred, low-dose pimozide was added.


RESULTS
In six out of seven patients, the addition of pimozide to a serotonin reuptake blocker led to an improvement in hair pulling. In patients who were able to tolerate their medication, this response was sustained.


CONCLUSIONS
Augmentation of serotonergic agents with dopamine blockers may play a role in the treatment of trichotillomania. Further controlled trials of pimozide augmentation in trichotillomania are needed.
Stein
D J
DJ
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY.
Hollander
E
E
D000328:Adult; D002997:Clomipramine / Q000627:therapeutic use; D015897:Comorbidity; D004298:Dopamine / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D014179:Neurotransmitter Uptake Inhibitors / Q000627:therapeutic use*; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D010868:Pimozide / Q000008:administration & dosage* / Q000627:therapeutic use; D012701:Serotonin / Q000502:physiology*; D014256:Trichotillomania / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology
D014179:Neurotransmitter Uptake Inhibitors; D005473:Fluoxetine; D010868:Pimozide; D012701:Serotonin; D002997:Clomipramine; D004298:Dopamine