title: Alterations in host regulatory glycolytic enzymes during pathogenesis of primate malaria and following chloroquine therapy.
abstract: Hexokinase, phosphofructokinase and pyruvate kinase, the regulatory enzymes of the glycolytic sequence, showed progressive increases in their activities with the rise of parasitaemia in Plasmodium knowlesi-infected rhesus monkey serum and red blood cells. Chloroquine therapy cleared the parasitaemia in 72 h and brought the elevated levels of these enzymes back to almost normal in about 30 days.
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Sahni
authors.forename: N
authors.initials: N
authors.lastname: Saxena
authors.forename: S K
authors.initials: SK
authors.lastname: Puri
authors.forename: G P
authors.initials: GP
authors.lastname: Dutta
authors.forename: V C
authors.initials: VC
authors.lastname: Pandey
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D006593:Hexokinase / Q000097:blood*; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy / Q000201:enzymology*; D010732:Phosphofructokinase-1 / Q000097:blood*; D016790:Plasmodium knowlesi; D011770:Pyruvate Kinase / Q000097:blood*
chemical_list: D002738:Chloroquine; D006593:Hexokinase; D010732:Phosphofructokinase-1; D011770:Pyruvate Kinase