title: Embryoscopy: a closer look at first-trimester diagnosis and treatment.
abstract: Advancing technology has made the fetus and its environment even more accessible to prenatal diagnosis and treatment. The current approach to prenatal diagnosis relies mainly on the use of high-resolution ultrasonography. However, as attempts are made to conduct antenatal diagnoses earlier in gestation, the limits of ultrasonography are approached. Embryoscopy allows for direct visualization of the first-trimester fetus with a fiberoptic endoscope. A customized side channel enables the operator to pass a variety of diagnostic tools and gain access into the fetal circulation. The further development and refinement of this technology are expected to change early prenatal diagnosis and treatment considerably. The potential contribution of this technique to perinatal medicine is readily apparent when it is placed in historic context. Undoubtedly, many ethical, legal, and regulatory questions will have to be addressed before the full potential of embryoscopy is realized. The responsibility for the judicious use of this powerful technology for prenatal intervention will have to be shared by the scientific community and a well-informed public.
authors.affiliation: Department of Obstetrics and Gynecology, Temple University School of Medicine, Philadelphia, PA 19140.
authors.forename: E A
authors.initials: EA
authors.lastname: Reece
authors.forename: S
authors.initials: S
authors.lastname: Rotmensch
authors.forename: J
authors.initials: J
authors.lastname: Whetham
authors.forename: M
authors.initials: M
authors.lastname: Cullen
authors.forename: J C
authors.initials: JC
authors.lastname: Hobbins
mesh_terms: D019723:Endoscopes; D004724:Endoscopy / Q000379:methods; D005260:Female; D005315:Fetal Diseases / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D005333:Fetus / Q000473:pathology*; D005336:Fiber Optic Technology; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*; D014465:Ultrasonics