title: [The definitions and classifications of carcinogenesis, mutagenesis and teratogenesis used by national and international agencies and institutions].
abstract: Classifications of carcinogenesis, mutagenesis and teratogenesis used by the National Toxicological Advisory Committee in Italy (CCTN), the Commission of the European Communities (CEC), the Environmental Protection Agency in the USA (EPA), the International Agency for Research on Cancer (IARC), and the National Toxicology Programme in the USA (NPT) are examined and commented on, with a synopsis of several allocations made by the above organizations. However, the authors consider it advisable to redefine the categories and create 5 groups of substances (designated C1 to C5), on the basis of given definitions, with the aim of rendering the allocations comparable. This procedure is used solely for carcinogenesis and excludes the NTP. From such comparison, good agreement was found between CCTN and EPA and between CCTN and CEC, whereas agreement between IARC and other organizations was poor.
authors.affiliation: Laboratorio di Igiene Ambientale, Istituto Superiore di Sanità, Roma.
authors.forename: N
authors.initials: N
authors.lastname: Mucci
authors.forename: L
authors.initials: L
authors.lastname: Rossi
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000145:classification* / Q000209:etiology; D000047:Academies and Institutes; D002273:Carcinogens / Q000145:classification; D005060:Europe; D006801:Humans; D007390:International Agencies; D007558:Italy; D016296:Mutagenesis / Q000187:drug effects*; D009153:Mutagens / Q000145:classification; D009369:Neoplasms / Q000139:chemically induced / Q000145:classification*; D013723:Teratogens / Q000145:classification; D009626:Terminology as Topic; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D002273:Carcinogens; D009153:Mutagens; D013723:Teratogens
vernacular_title: Definizioni e allocazioni di cancerogenesi, mutagenesi e teratogenesi da parte di alcune agenzie ed istituzioni nazionali ed internazionali.