Treatment of small intestinal fistulas with octreotide, a somatostatin analog.
Three patients with external small bowel fistulas were successfully treated with bowel rest, total parenteral nutrition, and the somatostatin analog, octreotide. Two of the patients had received prior multimodality therapy, including radiation, for gynecologic cancer. The time intervals to fistula closure were 2 days, 10 days, and 5 weeks after initiation of octreotide therapy. The efficacy of octreotide combined with total parenteral nutrition in the treatment of external enteric fistulas supports its routine use, especially in previously irradiated patients.
Boike
G M
GM
Department of Obstetrics and Gynecology, Jackson Memorial Medical Center/University of Miami School of Medicine, Florida.
Sightler
S E
SE
Averette
H E
HE
D002294:Carcinoma, Squamous Cell / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects; D007077:Ileal Diseases / Q000209:etiology / Q000628:therapy*; D007412:Intestinal Fistula / Q000209:etiology / Q000628:therapy*; D007579:Jejunal Diseases / Q000209:etiology / Q000628:therapy*; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000209:etiology / Q000601:surgery; D010289:Parenteral Nutrition, Total; D010502:Perineum; D002583:Uterine Cervical Neoplasms / Q000601:surgery; D014624:Vaginal Fistula / Q000209:etiology / Q000628:therapy*
D015282:Octreotide