Distal limb deficiency following chorionic villus sampling?
We have reviewed the follow-up of almost 3000 completed pregnancies in the Münster CVS Program and identified 4 children with distal limb deficiencies. Two cases involved only minor anomalies of distal digital phalanges. One child had a Hanhart anomaly (hypoglossia hypodactylia). We also reviewed 24 cases of limb defects following CVS reported previously. With the exception of a single series, neither the overall incidence of affected children nor cases reported from larger series provide unambiguous evidence of an increased risk of distal limb deficiency caused by CVS.
Schloo
R
R
Department of Human Genetics, Universitätsklinik Münster, Germany.
Miny
P
P
Holzgreve
W
W
Horst
J
J
Lenz
W
W
D002675:Child, Preschool; D015193:Chorionic Villi Sampling / Q000009:adverse effects* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D017880:Limb Deformities, Congenital; D011247:Pregnancy; D011261:Pregnancy Trimester, First