Progestin-induced fatty acid synthetase in human mammary tumors: from molecular to clinical studies.
Fatty acid synthetase (FAS) is one of the first well-characterized progestin-induced proteins with available antibodies and cDNA. This paper reviews basic studies on FAS regulation in human breast cancer cell lines and recent data on the possible clinical significance of this new marker of hormone responsiveness in mammary cancer and benign breast diseases.
Chalbos
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D
Unité INSERM 148 Hormones and Cancer, Montpellier, France.
Joyeux
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C
Galtier
F
F
Rochefort
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H
D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000201:enzymology*; D004790:Enzyme Induction; D064429:Fatty Acid Synthases / Q000235:genetics / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011372:Progestins / Q000494:pharmacology* / Q000502:physiology; D011980:Receptors, Progesterone / Q000378:metabolism
D014408:Biomarkers, Tumor; D011372:Progestins; D011980:Receptors, Progesterone; D064429:Fatty Acid Synthases