NPY-(18-36) and pertussis toxin distinguish between the negative and positive contractile effects of neuropeptide Y (NPY) in ventricular cardiomyocytes.
The mechanism of action of NPY to produce contractions of adult rat ventricular myocytes was investigated. Positive effects were mediated through an L-type Ca2+ channel. Negative effects, linked through an inhibitory G-protein to a transient outward K+ channel, could be antagonised by NPY-(18-36).
Millar
B C
BC
Department of Therapeutics and Pharmacology, Queen's University of Belfast.
McDermott
B J
BJ
Piper
H M
HM
Balasubramaniam
A
A
Weis
T
T
D000818:Animals; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006352:Heart Ventricles; D009200:Myocardial Contraction / Q000187:drug effects*; D009478:Neuropeptide Y / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D037342:Pertussis Toxin; D051381:Rats; D010566:Virulence Factors, Bordetella / Q000494:pharmacology*
D009478:Neuropeptide Y; D010446:Peptide Fragments; D010566:Virulence Factors, Bordetella; C059889:neuropeptide Y (18-36); D037342:Pertussis Toxin