Studies on direct intraperitoneal insemination in the management of male factor, cervical factor, unexplained and immunological infertility.
One-hundred-and-twenty couples with male factor, cervical factor, unexplained or immunological infertility underwent direct intraperitoneal insemination (DIPI) of capacitated spermatozoa, combined with ovarian stimulation for a total of 254 cycles. Pregnancy occurred in 47 cycles, resulting in an overall pregnancy rate of 40.5% per patient (two pregnancies occurred in two patients) and a cycle fecundity of 18.5%. Of the patients, 23 have delivered live infants (one twins, 22 singletons), 15 (32%) miscarried and 9 have ongoing pregnancies. The cycle fecundity rates increased with increasing sperm concentration and total progressive motile count, both before and after sperm preparation (r = 0.8161, r = 0.8717 and r = 0.759, r = 0.795, respectively). However, there were two pregnancies where the inseminates had a count of 0.1 x 10(6) total motile spermatozoa. DIPI as an outpatient, in-vivo conception procedure offers encouraging results and is recommended before attempting more costly and invasive assisted reproduction techniques.
Turhan
N O
NO
University of Modena, Department of Obstetrics and Gynaecology, Italy.
Artini
P G
PG
D'Ambrogio
G
G
Droghini
F
F
Volpe
A
A
Genazzani
A R
AR
D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000503:physiopathology*; D007248:Infertility, Male / Q000209:etiology / Q000503:physiopathology*; D007274:Injections, Intraperitoneal; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D013075:Sperm Capacitation; D013081:Sperm Motility