title: [Mechanisms of resistance to dactimicin and isepamicin in clinical strains of gram-negative rods isolated in Czechoslovakia].
abstract: Dactamicin is a new member of the pseudo-disaccharide group of antibiotics. It is structurally close to astromicin. Dactimicin is active against a wide variety of bacteria, including resistant strains with aminoglycoside-inactivating enzymes. Isepamicin is a broad-spectrum aminoglycoside, a derivative of gentamicin B. It is also active against many aminoglycoside-resistant strains. In a series of gram-negative bacterial isolates from various Czecho-Slovak regions, in vitro investigation yielded a good activity of dactimicin and isepamicin against amikacin- and gentamicin-resistant strains producing the enzyme AAC/6'/ or a combination of AAC/6'/ + ANT/2"/ enzymes. Dactimicin was not effective against strains producing the enzyme AAC/3/-I, and isepamicin was not effective or only slightly effective against bacterial isolates producing a combination of AAC/6'/ + AAC/3/ enzymes. (Tab. 3, Fig. 2, Ref. 10.).
authors.affiliation: Ustav experimentálnej farmakológie SAV, Bratislave, CSFR.
authors.forename: M
authors.initials: M
authors.lastname: Kettner
authors.forename: G H
authors.initials: GH
authors.lastname: Miller
authors.forename: S
authors.initials: S
authors.lastname: Inouye
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003604:Czechoslovakia; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006268:Health Facilities
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; C023527:dactimicin; C016927:isepamicin
vernacular_title: Mechanizmy rezistencie daktimicínu a izepamicínu proti cesko-slovenským klinickým kmenom gramnegatívnych paliciek.