Morphological features of degenerating oligodendrocytes in twitcher mice.
The morphological features of degenerating oligodendrocytes in twitcher mice were examined by a modified iron histochemical technique. Oligodendrocytes in twitcher mice were found to have several features distinct from oligodendrocytes in normal mice; swellings at different sites along their processes, swollen soma and an increase in iron-rich, oval structures in their cytoplasm. In addition to changes in oligodendrocyte morphology, endothelial cells in brains of twitcher mice were found to be highly enriched with iron.
LeVine
S M
SM
Department of Physiology, University of Kansas Medical Center, Kansas City 66160.
Torres
M V
MV
D000818:Animals; D003593:Cytoplasm / Q000648:ultrastructure; D006651:Histocytochemistry; D051379:Mice; D008818:Mice, Neurologic Mutants; D009410:Nerve Degeneration / Q000502:physiology; D009836:Oligodendroglia / Q000648:ultrastructure*