[Effect of ANP on angiotensin II--stimulated multiplication and c-fos oncogene expression of SHR vascular smooth muscle cells].
By means of technique of cell culture, 3H-thymidine incorporation and dot blot, it was demonstrated that angiotensin II (AGT II) stimulated proliferation and c-fos oncogene expression in cultured SHR vascular smooth muscle cells (VSMC) in a dose-dependent manner. This effect of AGT II was significantly inhibited by co-incubation with ANP. The results suggest that proliferation of VSMC is regulated by some interaction between AGT II and ANP.
Wu
J M
JM
Laboratory of Cardiopulmonary Endocrinology, Beijing Medical University.
Sun
S D
SD
Liao
Y B
YB
Tang
C S
CS
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001011:Aorta; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D002455:Cell Division; D002478:Cells, Cultured; D005260:Female; D005786:Gene Expression Regulation; D016762:Genes, fos; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D011918:Rats, Inbred SHR
D000804:Angiotensin II; D009320:Atrial Natriuretic Factor