Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells.
One human and six murine tumor cell lines of lymphoid origin were assessed for growth in the presence of three commonly used antiepileptic drugs (AEDs). All seven lines were sensitive to the growth slowing effects of phenytoin (PHT) and carbamazepine (CBZ). Six lines showed a similar effect when exposed to valproic acid (VPA), while one murine B cell line was resistant to inhibition of growth by VPA.
Tittle
T V
TV
Research Service, Veterans Affairs Medical Center, Portland, Oregon 97207.
Schaumann
B A
BA
Rainey
J E
JE
Taylor
K
K
D002220:Carbamazepine / Q000378:metabolism / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D046508:Culture Techniques / Q000379:methods; D006801:Humans; D007700:Kinetics; D007938:Leukemia; D008223:Lymphoma; D010672:Phenytoin / Q000378:metabolism / Q000494:pharmacology*; D012044:Regression Analysis; D014635:Valproic Acid / Q000378:metabolism / Q000494:pharmacology*
D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin