title: Anatomic basis for the injury current producing ST-segment shifts on the body surface ECG.
abstract: ST-segment depression is the characteristic electrocardiographic response to myocardial ischemia. A hypothesis is presented defining the structural and functional requirements for ischemic blood flow and ST-T wave potential gradients for ST-segment depression to occur. Both flow and potential gradients may be either transmural or transventricular. ST-segment depression results only when both are concordant (e.g., both transmural); however, ischemic ST-segment depression does not follow when flow and potential gradients are discordant (e.g., one transmural and one transventricular).
authors.affiliation: Department of Medicine, College of Medicine, University of Tennessee, Memphis 38163.
authors.forename: D M
authors.initials: DM
authors.lastname: Mirvis
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D004562:Electrocardiography / Q000379:methods*; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D012815:Signal Processing, Computer-Assisted