title: [Amlodipine: pharmacokinetic and pharmacodynamic profile of a calcium antagonist with prolonged effect].
abstract: Amlodipine is a new calcium antagonist of the 1.4-dihydropyridine group for treatment of hypertension and angina pectoris. Amlodipine is distinct from other calcium antagonists by its pharmacokinetic profile: slower onset of action with less acute vasodilatation associated side effects and a sustained antihypertensive and anti-anginal efficacy over 24 hours.
authors.forename: G
authors.initials: G
authors.lastname: Heynen
mesh_terms: D017311:Amlodipine; D000787:Angina Pectoris / Q000188:drug therapy; D000818:Animals; D002121:Calcium Channel Blockers / Q000493:pharmacokinetics*; D055598:Chemical Phenomena; D002621:Chemistry; D004095:Dihydropyridines / Q000493:pharmacokinetics; D006801:Humans; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D017311:Amlodipine; D009543:Nifedipine
vernacular_title: Amlodipin: pharmakokinetisches und pharmakodynamisches Profil eines Kalziumantagonisten mit langanhaltender Wirkung.