Symmetrical adenovirus minichromosomes have hairpin replication intermediates.
A special class of panhandles (hairpin or foldback structures) arising from the replication of symmetrical adenovirus (Ad) minichromosome dimers and oligomers have been identified by two-dimensional gel electrophoresis. Hairpins provide evidence for replicative intermediates in the pathway for Ad complementary-strand synthesis. Furthermore, larger inverted sequences give Ad minichromosomes a replicative advantage.
Hu
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Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331.
Xu
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Wang
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Pearson
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Pearson
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D000256:Adenoviridae / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D015180:Electrophoresis, Gel, Two-Dimensional; D009690:Nucleic Acid Conformation; D010957:Plasmids / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D014162:Transfection / Q000235:genetics
D004279:DNA, Viral