Mechanisms in lacunar infarction.
OBJECTIVE
Lacunes are thought to occur in patients with hypertension or diabetes mellitus as a result of small-vessel disease. This study evaluated the importance of other stroke mechanisms in a population of patients with lacunar infarction.


METHODS
We evaluated 108 consecutive patients with a lacune in the lenticulostriate distribution for other stroke risk factors such as carotid and cardiac disease.


RESULTS
Hypertension was present in 68% of the patients and diabetes mellitus in 37%; both occurred in 28% and neither occurred in 23%. Noninvasive carotid studies identified atherosclerotic plaque as a possible embolic source in 23%. By previously established criteria, 18% were at high risk for cardioembolism. Of those with hypertension or diabetes mellitus, 36% were at risk for a carotid or cardiac embolus. Of those without hypertension or diabetes mellitus, 32% had a possible carotid or cardiac etiology.


CONCLUSIONS
The high incidence of carotid and cardiac disease in those with and without hypertension or diabetes mellitus suggests the importance of other stroke mechanisms in this population. Patients with lacunar infarction should therefore be evaluated for other causes of stroke that may be treatable.
Horowitz
D R
DR
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029.
Tuhrim
S
S
Weinberger
J M
JM
Rudolph
S H
SH
D000368:Aged; D001157:Arterial Occlusive Diseases / Q000150:complications; D002536:Cerebral Arteries; D002544:Cerebral Infarction / Q000150:complications* / Q000000981:diagnostic imaging; D003327:Coronary Disease / Q000150:complications; D048909:Diabetes Complications; D004617:Embolism / Q000150:complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D002537:Intracranial Arteriosclerosis / Q000150:complications; D008297:Male; D014463:Ultrasonography