title: Systemic lupus erythematosus presenting with neurological disorders.
abstract: Six patients are described who developed a wide variety of neurological manifestations heralding systemic lupus erythematosus (SLE), which included epileptic seizures, stroke, peripheral polyradiculoneuropathy similar to Guillain-Barré syndrome, transverse myelopathy and multifocal disorders with remitting course mimicking multiple sclerosis. The peculiarity of these cases was that the neurological disorders remained the only manifestations of SLE for many years and the nervous system appeared to be the main target even after the development of systemic SLE. In five patients the prognosis was favourable and corticosteroid treatment led to prolonged remission.
authors.affiliation: Institute of Neurology, University of Ferrara, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Tola
authors.forename: E
authors.initials: E
authors.lastname: Granieri
authors.forename: L
authors.initials: L
authors.lastname: Caniatti
authors.forename: E
authors.initials: E
authors.lastname: Paolino
authors.forename: C
authors.initials: C
authors.lastname: Monetti
authors.forename: L
authors.initials: L
authors.lastname: Dovigo
authors.forename: R
authors.initials: R
authors.lastname: Scolozzi
authors.forename: P
authors.initials: P
authors.lastname: De Bastiani
authors.forename: M
authors.initials: M
authors.lastname: Carreras
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis*; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000209:etiology; D009188:Myelitis, Transverse / Q000175:diagnosis / Q000209:etiology; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology; D009902:Optic Neuritis / Q000175:diagnosis / Q000209:etiology; D012640:Seizures / Q000175:diagnosis / Q000209:etiology
chemical_list: D001323:Autoantibodies