Abnormal uptake of technetium-99m hexakis-2-methoxyisobutylisonitrile in a primary cardiac lymphoma.
Abnormally high uptake of technetium-99m hexakis-2-methoxyisobutylisonitrile (99mTc-SESTAMIBI) in the right ventricle and in the septum was observed in a 47-year-old woman initially presenting with dysarthria and left hemiparesis. Endomyocardial biopsy demonstrated a high-grade malignant non-Hodgkin's lymphoma. Complete remission was achieved by combined cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy and radiotherapy of the heart and mediastinum. The post-remission single photon emission tomography (SPET) 99mTc-SESTAMIBI study showed a homogeneous distribution pattern, in agreement with echocardiography computed tomography and magnetic resonance imaging. Increased uptake of 99mTc-SESTAMIBI, a myocardial perfusion agent, has been observed in some benign and malignant tumours. It may prove to be useful in the diagnosis and follow-up of malignancies.
Medolago
G
G
Department of Nuclear Medicine, Ospedali Riuniti di Bergamo, Italy.
Virotta
G
G
Pitì
A
A
Tespili
M
M
D'Adda
F
F
Rottoli
M R
MR
Comotti
B
B
Motta
T
T
Orlandi
C
C
Bertocchi
C
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006338:Heart Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011241:Prednisone / Q000008:administration & dosage; D011877:Radionuclide Imaging; D012074:Remission Induction; D017256:Technetium Tc 99m Sestamibi; D014750:Vincristine / Q000008:administration & dosage
D015609:Organotechnetium Compounds; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D017256:Technetium Tc 99m Sestamibi; D011241:Prednisone