Gastric potential difference measurement as a quantification of gastrointestinal tolerability comparing a buffered acetylsalicylic acid formulation versus plain acetylsalicylic acid.
Two different acetylsalicylic acid (ASA, CAS 50-78-2) formulations (Aspirin) were compared regarding their gastric mucosal tolerability. After administration of plain ASA, buffered ASA and ASA placebo the decrease of gastric potential difference (GPD) was measured. Evaluation of the GPD parameters showed a better tolerability of buffered ASA than of plain ASA. It was therefore concluded that buffered ASA effects less gastric mucosal irritation than plain ASA.
Jost
V
V
Institut für klinische Pharmakologie Bobenheim, Prof. Dr. Lücker GmbH, Grünstadt, Fed. Rep. of Germany.
Kuhn
I
I
Rogalla
K
K
Theiss
U
U
Lücker
P W
PW
D000328:Adult; D001241:Aspirin / Q000009:adverse effects*; D002021:Buffers; D004064:Digestive System / Q000187:drug effects*; D005753:Gastric Mucosa / Q000737:chemistry / Q000187:drug effects; D006801:Humans; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects
D002021:Buffers; D001241:Aspirin