Genetic differences in ethanol-induced hyperglycemia and conditioned taste aversion.
Genetic differences in the hyperglycemic response to acute ethanol exposure and ethanol-induced conditioned taste aversion were examined using inbred mice. Adult male C57BL/6J and DBA/2J mice were injected with ethanol (0-6 g/kg, I.P.) and blood glucose levels determined over 4 h. C57 mice demonstrated greater dose-dependent elevations in blood glucose compared to DBA mice. In a conditioned taste aversion procedure, water deprived mice received ethanol injections (1-4 g/kg, I.P.) immediately after access to a NaCl flavored solution. DBA mice developed aversion to the ethanol-paired flavor at a lower dose (2 g/kg) than C57 mice. These results provide further support for a possible inverse genetic relationship between sensitivity to ethanol-induced hyperglycemia and sensitivity to conditioned taste aversion.
Risinger
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Department of Medical Psychology, Oregon Health Sciences University, Portland 97201-3098.
Cunningham
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D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006943:Hyperglycemia / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013649:Taste / Q000502:physiology
D000431:Ethanol