title: Alternatively spliced annexin XI transcripts encode proteins that differ near the amino-terminus.
abstract: Annexins are a family of structurally related calcium-dependent phospholipid binding proteins. We recently described a new member of this family, bovine annexin XI [1]. Two kinds of cDNAs were identified corresponding to annexin XI mRNA variants A and B, which are generated by alternative splicing of identical primary transcripts. Annexin XI isoforms are predicted to differ at the amino-terminus, suggesting that they may have distinct biological roles.
authors.affiliation: Orthopaedic Research Laboratories, Massachusetts General Hospital, Boston 02114.
authors.forename: C A
authors.initials: CA
authors.lastname: Towle
authors.forename: L
authors.initials: L
authors.lastname: Weissbach
authors.forename: B V
authors.initials: BV
authors.lastname: Treadwell
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017302:Annexins; D001483:Base Sequence; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002417:Cattle; D002478:Cells, Cultured; D004247:DNA; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012326:RNA Splicing; D014158:Transcription, Genetic
chemical_list: D017302:Annexins; D002135:Calcium-Binding Proteins; D004247:DNA