title: Osteosarcoma: chemotherapy-induced changes at MR imaging.
abstract: Fifty-seven patients undergoing chemotherapy for osteosarcoma underwent evaluation with magnetic resonance (MR) imaging to identify changes related to a good or poor response. Spin-echo MR images obtained after preoperative chemotherapy were compared with images obtained before treatment. Histopathologic examination of each resected specimen was used to quantify the response. An increase in tumor volume and increased or unchanged edema were predictive of a poor histopathologic response (predictive values, 85%-92%). Decreased or unchanged tumor volume and a decrease in edema were poor predictors of a good response (predictive values, 56%-62%). Improved tumor demarcation, an increase in the size of areas of low signal intensity, and a decrease in joint effusion occurred independently of histopathologic response in almost half of the patients. With a subjective interpretation of MR images, poor respondents can be identified if an increase in tumor volume or no decrease in the amount of edema is seen. Subjective criteria do not contribute to the identification of good respondents.
authors.affiliation: Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
authors.forename: H C
authors.initials: HC
authors.lastname: Holscher
authors.forename: J L
authors.initials: JL
authors.lastname: Bloem
authors.forename: D
authors.initials: D
authors.lastname: Vanel
authors.forename: J
authors.initials: J
authors.lastname: Hermans
authors.forename: M A
authors.initials: MA
authors.lastname: Nooy
authors.forename: A H
authors.initials: AH
authors.lastname: Taminiau
authors.forename: M
authors.initials: M
authors.lastname: Henry-Amar
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D017024:Chemotherapy, Adjuvant; D005260:Female; D005269:Femur / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D012516:Osteosarcoma / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D011300:Preoperative Care; D013977:Tibia / Q000473:pathology