Role of testosterone and dihydrotestosterone in spontaneous gynecomastia of adolescents.
To test a possible hormonal mechanism of gynecomastia at puberty, a group of pubertal spontaneous gynecomastia (PSG) and healthy young volunteers (HYV), Tanner's stage II-V, were studied. Peripheral blood samples were obtained for measuring follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), testosterone (T), dihydrotestosterone (DHT), estradiol (E-2) and estrone (E-1). No difference was established in steroids in pituitary hormonal concentration when both groups were compared on a sexual stage-matched control basis, except for T 2 SD in 5/9 subjects of PSG and DHT 2 SD in all of PSG. The T:DHT ratio varied from 5.0 to 15.4 in PSG and from 0.42 to 2.224 in HYV. Whether spontaneous gynecomastia might exist in an enzimatic blockade of 5 alpha-reductase and whether a decrease in the T:DHT ratio might favor the estrogen action for the progression of breast enlargement deserve further analysis.
Villalpando
S
S
Unidad de Investigación Clinica en Nutrición y, Instituto Mexicano del Seguro Social, México, DF.
Mondragón
L
L
Barrón
C
C
Pérez-Pastén
E
E
Castañeda
G
G
Alonso-Uriarte
R
R
Cortés-Gallegos
V
V
D000293:Adolescent; D013196:Dihydrotestosterone / Q000097:blood*; D006177:Gynecomastia / Q000097:blood*; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D013739:Testosterone / Q000097:blood*
D006728:Hormones; D013196:Dihydrotestosterone; D013739:Testosterone