Does chemotherapy of hematological malignancies affect DNA fingerprint pattern?
We analyzed DNA fingerprints of lymphoma patients to find out whether DNA damage caused by irradiation and chemotherapy can result in DNA fingerprint changes, and whether the differences found previously in leukemia patients could be partially due to the treatment. In this study we did not find any post-treatment DNA fingerprint differences in 33 lymphoma patients, concluding, that the therapy of hematological malignancies does not affect DNA fingerprint patterns. Further, the variations of methylation do not either explain the detected differences in leukemic patients.
Helminen
P
P
Laboratory of Molecular Genetics, NPHI, Helsinki, Finland.
D004249:DNA Damage; D016172:DNA Fingerprinting; D004273:DNA, Neoplasm / Q000235:genetics; D015252:Deoxyribonucleases, Type II Site-Specific; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000235:genetics / Q000532:radiotherapy*; D008745:Methylation
D004273:DNA, Neoplasm; C024669:endodeoxyribonuclease AluI; D015252:Deoxyribonucleases, Type II Site-Specific; C032229:GANTC-specific type II deoxyribonucleases