Tc-99m HMPAO labeled leukocytes superior to bone scan in the detection of osteomyelitis in children.
Seven children (aged 7 to 16 years) with confirmed osteomyelitis underwent imaging with Tc-99m HMPAO labeled leukocytes and with Tc-99m diphosphonates. The patients were scanned at 1/2 hour and at 3 hours. The scans were evaluated visually, and the lesion-to-normal bone ratios were quantitated. All the lesions on leukocyte scans and six out of seven lesions in bone scans were readily detectable 1/2 hour after injection of the radiopharmaceutical, but 3 hours is the better imaging time. In quantitative analysis, the lesion-to-normal bone ratio increased with leukocytes significantly higher than with the bone scans (P less than 0.05). When the scintigraphic findings were compared with surgical and radiologic results, the leukocyte images detected and localized lesions better than the bone scans. According to these preliminary results, Tc-99m HMPAO labeled leukocytes seem to offer a rapid and accurate method for detecting bone infections.
Lantto
T
T
Department of Nuclear Medicine, Päijät-Häme Central Hospital, Lahti, Finland.
Kaukonen
J P
JP
Kokkola
A
A
Laitinen
R
R
Vorne
M
M
D000293:Adolescent; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D004164:Diphosphonates; D005260:Female; D006801:Humans; D007962:Leukocytes; D008297:Male; D015609:Organotechnetium Compounds; D010019:Osteomyelitis / Q000000981:diagnostic imaging*; D010091:Oximes; D011877:Radionuclide Imaging; D019690:Technetium Tc 99m Exametazime; D013997:Time Factors
D004164:Diphosphonates; D015609:Organotechnetium Compounds; D010091:Oximes; C033905:technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid; D019690:Technetium Tc 99m Exametazime