title: Symmetrical adenovirus minichromosomes have hairpin replication intermediates.
abstract: A special class of panhandles (hairpin or foldback structures) arising from the replication of symmetrical adenovirus (Ad) minichromosome dimers and oligomers have been identified by two-dimensional gel electrophoresis. Hairpins provide evidence for replicative intermediates in the pathway for Ad complementary-strand synthesis. Furthermore, larger inverted sequences give Ad minichromosomes a replicative advantage.
authors.affiliation: Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331.
authors.forename: C H
authors.initials: CH
authors.lastname: Hu
authors.forename: F Y
authors.initials: FY
authors.lastname: Xu
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.forename: A N
authors.initials: AN
authors.lastname: Pearson
authors.forename: G D
authors.initials: GD
authors.lastname: Pearson
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D015180:Electrophoresis, Gel, Two-Dimensional; D009690:Nucleic Acid Conformation; D010957:Plasmids / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D014162:Transfection / Q000235:genetics
chemical_list: D004279:DNA, Viral