Placental protein 14 in human in-vitro fertilization early pregnancies.
Placental protein 14 (PP14) and human chorionic gonadotrophin (HCG) were analysed in patients participating in an in-vitro fertilization-embryo transfer programme which did not include any kind of luteal support. Women with normal pregnancies, spontaneous abortions, ectopic pregnancies, biochemical pregnancies and non-pregnant women were compared. A combination of HCG and PP14 analyses distinguished between normal and abnormal implantation as early as 15 days after oocyte retrieval. The product of HCG (IU/l) and PP14 (micrograms/l) concentrations differed significantly between normal pregnancy, spontaneous abortion and ectopic pregnancy (P = 0.0248). It is concluded that both endometrial (PP14) and trophoblastic (HCG) markers, when used in combination, exhibit changes in abnormal implantation which may be clinically useful.
Nylund
L
L
Department of Obstetrics and Gynaecology, Karolinska Institute, Huddinge University Hospital, Sweden.
Gustafson
O
O
Lindblom
B
B
Pousette
A
A
Seppälä
M
M
Riittinen
L
L
Akerlöf
E
E
D000022:Abortion, Spontaneous / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood*; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000097:blood*; D011261:Pregnancy Trimester, First / Q000097:blood*; D011271:Pregnancy, Ectopic / Q000097:blood
D006063:Chorionic Gonadotropin; D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins