Inhalation of organic solvents does not promote synovial tissue inflammation in rats.
Organic solvent exposure is known to give rise to a variety of manifestations in the nervous system both in man and in animals. Cardiac and skeletal muscle can also be affected, and strange collagen-like diseases, arthritis and arthralgia have been reported. In this work PVG rats were exposed to inhalation of toluene, commercial hexane, an industrial steel primer, and a cold vulcanizer for 4 months. No signs of synovitis appeared, either macroscopically or histologically, and there were no systemic signs of inflammation as detected by increased acute phase reactants.
Omdal
R
R
Department of Internal Medicine, Rogaland Central Hospital, Stavanger, Norway.
Husby
G
G
Refsum
S B
SB
D000280:Administration, Inhalation; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006586:Hexanes / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D012997:Solvents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D013585:Synovitis / Q000139:chemically induced* / Q000473:pathology; D014050:Toluene / Q000008:administration & dosage / Q000494:pharmacology
D006586:Hexanes; D012997:Solvents; D014050:Toluene