title: De novo complex chromosome rearrangement in identical twins with multiple congenital anomalies.
abstract: A de novo and apparently balanced complex chromosome rearrangement (CCR) was found in monozygotic (MZ) twin infants with multiple congenital anomalies. The rearrangement involved 4 chromosomes with 6 breakpoints including 2p23, 2q13, 2q21.1, 3p23, 11q13.1, and 12q24.1. This seems to be the first report of a CCR in MZ twins. The relationship between this chromosome abnormality and MZ twinning is discussed.
authors.affiliation: Department of Pediatrics, Okayama University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Wakita
authors.forename: K
authors.initials: K
authors.lastname: Narahara
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
authors.forename: Y
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: S
authors.initials: S
authors.lastname: Ninomiya
authors.forename: R
authors.initials: R
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Kikkawa
authors.forename: Y
authors.initials: Y
authors.lastname: Seino
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic; D014430:Twins, Monozygotic / Q000235:genetics*