title: Effects of long-term monounsaturated- vs polyunsaturated-enriched diets on lipoproteins in healthy men and women.
abstract: The effect of dietary-fat saturation on plasma lipoprotein concentrations was assessed in 46 men and 32 women placed on a diet enriched in polyunsaturated fatty acids (sunflower oil) for 12 wk and, under isocaloric conditions, on a diet enriched in monounsaturated fatty acids (olive oil) for the next 16 wk in men and 28 wk in women. Fat comprised 37% of the total energy intake in men and 36% in women. At the end of the monounsaturated fatty acid diet no change occurred in total cholesterol (TC) in men but it increased by 9% in women. High-density-lipoprotein (HDL) cholesterol increased by 17% in men and by 30% in women. The atherogenic index (TC:HDL cholesterol) fell significantly in both sexes. No significant changes occurred in plasma low-density-lipoprotein cholesterol or in total triglycerides values. These data show that when compared with polyunsaturates, monounsaturates increased HDL cholesterol and reduced the atherogenic risk profile in both sexes.
authors.affiliation: Department of Internal Medicine, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Mata
authors.forename: L A
authors.initials: LA
authors.lastname: Alvarez-Sala
authors.forename: M J
authors.initials: MJ
authors.lastname: Rubio
authors.forename: J
authors.initials: J
authors.lastname: Nuño
authors.forename: M
authors.initials: M
authors.lastname: De Oya
mesh_terms: D000293:Adolescent; D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D002149:Energy Intake; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D000074242:Sunflower Oil
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D008074:Lipoproteins; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D002784:Cholesterol