Pharmacodynamic properties of propofol during recovery from anaesthesia.
Propofol was used to induce and maintain anaesthesia in 20 healthy adult ASA physical status 1 patients undergoing dental surgery. Recovery was studied using psychometric tests and clinical assessment while propofol blood levels were obtained at the same study times. Recovery was rapid and there were no significant differences 60 min after anaesthesia (t60) for the tracing test and 90 min for the choice reaction time. All patients were orientated in time at t30 and in space at t45; Stewart's score was maximal in all patients at t60; recovery of normal walking was slower, i.e. t120. Return to baseline for psychometric function was linked to a decrease in propofol blood level, for both the tracing test (P less than 10(-6)) and the choice reaction time (P less than 10(-3)). We conclude that propofol is a suitable anaesthetic agent for induction and maintenance of short duration dental anaesthesia.
Paut
O
O
Department of Anesthesiology and Intensive Care, Groupe Hospitalier de la Timone, Marseille, France.
Guidon-Attali
C
C
Viviand
X
X
Lacarelle
B
B
Bouffier
C
C
François
G
G
D000328:Adult; D000704:Analysis of Variance; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001049:Apnea / Q000139:chemically induced; D003071:Cognition / Q000187:drug effects; D003371:Cough / Q000209:etiology; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D011187:Posture; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors; D016138:Walking
D015742:Propofol