Effect of dehydration on the disposition kinetics of erythromycin in rabbits.
The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water-deprived population.
Ahmad
M
M
Department of Pharmacology, Aga Khan University Medical College Karachi, Pakistan.
Niazi
S K
SK
Ahmad
T
T
Muzaffar
N A
NA
Nawaz
M
M
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D003681:Dehydration / Q000378:metabolism*; D004917:Erythromycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D008055:Lipids / Q000097:blood; D008297:Male; D011817:Rabbits
D001786:Blood Glucose; D001798:Blood Proteins; D008055:Lipids; D004917:Erythromycin