title: Efficacy of an ivermectin/pyrantel pamoate chewable formulation against the canine hookworms, Uncinaria stenocephala and Ancylostoma caninum.
abstract: The effectiveness of the combination of pyrantel pamoate (5 mg kg-1) and ivermectin (6 micrograms kg-1) against the canine hookworms Uncinaria stenocephala and Ancylostoma caninum was determined. This combination is intended for monthly use as a heartworm preventative and for treatment and control of canine hookworms. The formulation was found to be effective (99.6% reduction in worm burdens) against both species of hookworms in experimentally infected dogs. No adverse effects due to the drug combination were observed in any dog during the course of this study.
authors.affiliation: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104.
authors.forename: T J
authors.initials: TJ
authors.lastname: Nolan
authors.forename: J M
authors.initials: JM
authors.lastname: Hawdon
authors.forename: S L
authors.initials: SL
authors.lastname: Longhofer
authors.forename: C P
authors.initials: CP
authors.lastname: Daurio
authors.forename: G A
authors.initials: GA
authors.lastname: Schad
mesh_terms: D000284:Administration, Oral; D000722:Ancylostoma / Q000187:drug effects; D000723:Ancylostomatoidea / Q000187:drug effects; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations; D005243:Feces / Q000469:parasitology; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy / Q000662:veterinary*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*; D013047:Specific Pathogen-Free Organisms
chemical_list: D004338:Drug Combinations; D007559:Ivermectin; D011716:Pyrantel Pamoate