title: MacroH2A, a core histone containing a large nonhistone region.
abstract: A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.
authors.affiliation: Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, PA 19111.
authors.forename: J R
authors.initials: JR
authors.lastname: Pehrson
authors.forename: V A
authors.initials: VA
authors.lastname: Fried
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D006657:Histones / Q000737:chemistry* / Q000235:genetics; D016350:Leucine Zippers; D008099:Liver / Q000648:ultrastructure*; D046911:Macromolecular Substances; D051379:Mice; D008969:Molecular Sequence Data; D009707:Nucleosomes / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D051381:Rats; D012689:Sequence Homology, Nucleic Acid
chemical_list: D006657:Histones; D046911:Macromolecular Substances; D009707:Nucleosomes; D004247:DNA