title: Polycystic kidney disease: I. Etiology and pathogenesis.
abstract: Geneticists and cell biologists are simultaneously studying the disease's underlying mechanisms. Although a great many questions remain about cyst formation and its role in kidney failure, three fundamental constructs on its etiology and pathogenesis have been generated: renal tubular epithelial proliferation, fluid accumulation, and remodeling of the extracellular matrix.
authors.affiliation: Department of Medicine, University of Kansas School of Medicine, Kansas City.
authors.forename: J J
authors.initials: JJ
authors.lastname: Grantham
mesh_terms: D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008967:Molecular Biology; D007690:Polycystic Kidney Diseases / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology