Effects of the 5HT1A agonist, 8-OH-DPAT, on operant food intake in non-deprived rats.
The aim of the present study was to determine whether the hyperphagia produced by systemic administration of 8-OH-DPAT is independent of drug-induced chewing or gnawing behaviour. The effects of 8-OH-DPAT (15.625-500 micrograms kg-1, s.c.) were therefore investigated on operant food intake in non-deprived rats. Low doses (i.e. 15.625-62.5 micrograms kg-1) increased operant food intake. Drug-induced stereotypy disrupted operant responding at the higher doses. The results thus suggest that 8-OH-DPAT-induced hyperphagia is independent of chewing or gnawing behaviour.
Ebenezer
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Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, Portsmouth, Hampshire, UK.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D013764:Tetrahydronaphthalenes; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin