title: [Comparative study of the effectiveness of continuous or intermittent courses of a phlebotonic drug on venous disorders disclosed or aggravated by oral, estrogen-progesterone contraceptives].
abstract: In patients with venous disorders related to oral contraceptives, venotonic treatment should be prescribed for as long as contraception is maintained. 2,295 patients between the ages of 20 and 40 years with venous insufficiency revealed or aggravated by oral contraceptives were randomised to receive venotonic treatment for one month either continuously or in parallel with active contraceptive treatment, from the 10th to the 28th day. The results demonstrated the values of prolonged treatment of venous disease, as its effects persisted and were reinforced with time. The possibility of intermittent prescription would appear to improve compliance and lower the cost of treatment while ensuring comparable long-term efficacy.
authors.affiliation: Département de Biostatistiques et Informatique Médicale, CHRU, Dijon.
authors.forename: F A
authors.initials: FA
authors.lastname: Allaert
authors.forename: F
authors.initials: F
authors.lastname: Vin
authors.forename: M
authors.initials: M
authors.lastname: Levardon
mesh_terms: D000328:Adult; D000872:Anthocyanins / Q000008:administration & dosage* / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000008:administration & dosage* / Q000191:economics / Q000627:therapeutic use; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D016527:Drug Costs; D005260:Female; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000627:therapeutic use; D010349:Patient Compliance; D012503:Saponins / Q000008:administration & dosage* / Q000627:therapeutic use; D014689:Venous Insufficiency / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D000872:Anthocyanins; D002317:Cardiovascular Agents; D003278:Contraceptives, Oral, Hormonal; D004338:Drug Combinations; D012503:Saponins; C021102:Veinobiase; D008094:Lithium; D001205:Ascorbic Acid
vernacular_title: Etude comparative de l'efficacité des cures continues ou discontinues d'un phlébotonique sur les troubles veineux révélés ou aggravés par la contraception orale estroprogestative.