Suppression of corneal neovascularization with cyclosporine.
We sought to determine if cyclosporine, which has been shown to suppress corneal allograft rejection, could also suppress corneal neovascularization induced by interleukin 2. Thirty A/J mice were treated with daily intramuscular injections of cyclosporine (25 mg/kg in olive oil) for 3 days before and 2 weeks following the intrastromal injection of 0.5 microL (5 IU) of recombinant mouse interleukin 2. Controls received intramuscular injections of olive oil. The mean area of corneal neovascularization 4, 8, and 12 weeks after injection was 9.2, 9.1, and 9.2 mm2, respectively, in controls, and 5.0, 5.2, and 5.2 mm2 in cyclosporine-treated mice (P less than .02; Student's t test). Cyclosporine causes a significant reduction in interleukin 2-induced corneal neovascularization that may, in part, account for its ability to prolong corneal allograft survival in high-risk cases.
Lipman
R M
RM
Department of Ophthalmology, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612.
Epstein
R J
RJ
Hendricks
R L
RL
D000818:Animals; D016510:Corneal Neovascularization / Q000473:pathology / Q000517:prevention & control*; D016572:Cyclosporine / Q000097:blood / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007376:Interleukin-2; D051379:Mice; D008805:Mice, Inbred A; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D011994:Recombinant Proteins
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins; D016572:Cyclosporine