title: Comprehensive management including interstitial brachytherapy for locally advanced or recurrent gynecologic malignancies.
abstract: Radical therapy for locally advanced or recurrent gynecologic malignancies (LARGM) may include interstitial brachytherapy (IB) when intracavitary brachytherapy is impossible or inadequate and external beam teletherapy would be limited by surrounding normal tissue tolerance. Sixteen women received IB as all or part of their treatment at North Shore University Hospital for the treatment of locally advanced primary or recurrent tumors of gynecologic origin from May 1988 through September 1990. Primary sites included the vulva (3), vagina (2), cervix (7), and endometrium (4). Radiosensitizing chemotherapy was used in 8 patients. With a median follow-up of 23 months (range, 12-44 months), 11 patients (69%) have experienced continuous local control of their tumor and 4 patients (25%) have experienced severe complications. While significant risks may attend the use of IB, IB is an integral part of management for select patients with LARGM.
authors.affiliation: Division of Radiation Oncology, New York University Medical Center, New York.
authors.forename: S
authors.initials: S
authors.lastname: Rush
authors.forename: J
authors.initials: J
authors.lastname: Lovecchio
authors.forename: D
authors.initials: D
authors.lastname: Gal
authors.forename: L
authors.initials: L
authors.lastname: DeMarco
authors.forename: L
authors.initials: L
authors.lastname: Potters
authors.forename: D
authors.initials: D
authors.lastname: DeBlasio
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage