title: Sinonasal hemangiopericytomas. A clinicopathologic and DNA content study.
abstract: The clinicopathologic and the flow cytometric DNA characteristics of 14 patients with sinonasal hemangiopericytomas are presented. Patient and tumor characteristics were similar to previously published series. Flow cytometric analysis revealed a diploid DNA pattern and low S-phase in 13 neoplasmas and an aneuploid DNA pattern with relatively high S-phase in one. Histopathologically, all diploid and low S-phase neoplasms displayed relatively uniform cellular features and low mitotic counts. All patients are alive and free of disease; one is still alive after a single recurrence. Our data suggest that sinonasal hemangiopericytomas are low-grade neoplasms as evidenced by their histomorphology and their DNA content. Recurrences are delayed and can be controlled.
authors.affiliation: Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: A K
authors.initials: AK
authors.lastname: el-Naggar
authors.forename: J G
authors.initials: JG
authors.lastname: Batsakis
authors.forename: G M
authors.initials: GM
authors.lastname: Garcia
authors.forename: M L
authors.initials: ML
authors.lastname: Luna
authors.forename: H
authors.initials: H
authors.lastname: Goepfert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D006393:Hemangiopericytoma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm