Species restrictions demonstrated by the stimulation of equine cells with recombinant human interleukin-1.
Equine thymocytes, which respond to equine monocyte supernatants, do not respond to stimulation with recombinant human interleukin-1 alpha and beta, and equine synovial fibroblasts show a limited response in the form of prostaglandin E2 production without any evidence of neutral metalloproteinase production. Human interleukin-1 beta was about three to ten times as active on equine synovial cells as human interleukin-1 alpha in terms of prostaglandin E2 production. This preliminary evidence would suggest that there are qualitative and quantitative differences in the way recombinant human interleukin-1 stimulates human cells and the way in which it stimulates equine cells.
May
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Department of Veterinary Basic Sciences, Royal Veterinary College, Hatfield, Herfordshire, UK.
Hooke
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Lees
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D000818:Animals; D015232:Dinoprostone / Q000378:metabolism; D005347:Fibroblasts / Q000276:immunology; D006736:Horses / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D013045:Species Specificity; D013582:Synovial Fluid / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D007375:Interleukin-1; D011994:Recombinant Proteins; D015232:Dinoprostone