The mechanism of airway hyperresponsiveness following immediate asthmatic response in ovalbumin-sensitized guinea-pigs.
The mechanism of airway hyperresponsiveness (AH) following immediate asthmatic response (IAR) was investigated in ovalbumin (OA)-sensitized guinea-pigs. After IAR, airway responsiveness was significantly increased and propranolol-induced bronchoconstriction (PIB) was so severe that guinea-pigs died. A thromboxane (Tx) synthetase inhibitor CS-518 significantly inhibited AH and PIB, whereas a PAF receptor antagonist WEB-2086 was only slightly effective. These results suggest that TxA2 plays an important role and PAF a partial role in AH following IAR.
Minoguchi
K
K
First Department of Internal Medicine, School of Medicine, Showa University, Tokyo, Japan.
Adachi
M
M
Kobayashi
T
T
Takahashi
T
T
D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D001381:Azepines / Q000494:pharmacology / Q000627:therapeutic use; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000503:physiopathology*; D006168:Guinea Pigs; D008297:Male; D010047:Ovalbumin / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011738:Pyrilamine / Q000494:pharmacology; D013876:Thiophenes / Q000494:pharmacology / Q000627:therapeutic use; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use
D001381:Azepines; D010972:Platelet Activating Factor; D013876:Thiophenes; D014230:Triazoles; C052518:WEB 2086; C055806:RS 5186; D010047:Ovalbumin; D013930:Thromboxane-A Synthase; D011738:Pyrilamine