title: The ATP synthase (F0-F1) complex in oxidative phosphorylation.
abstract: The transmembrane electrochemical proton gradient generated by the redox systems of the respiratory chain in mitochondria and aerobic bacteria is utilized by proton translocating ATP synthases to catalyze the synthesis of ATP from ADP and P(i). The bacterial and mitochondrial H(+)-ATP synthases both consist of a membranous sector, F0, which forms a H(+)-channel, and an extramembranous sector, F1, which is responsible for catalysis. When detached from the membrane, the purified F1 sector functions mainly as an ATPase. In chloroplasts, the synthesis of ATP is also driven by a proton motive force, and the enzyme complex responsible for this synthesis is similar to the mitochondrial and bacterial ATP synthases. The synthesis of ATP by H(+)-ATP synthases proceeds without the formation of a phosphorylated enzyme intermediate, and involves co-operative interactions between the catalytic subunits.
authors.affiliation: Laboratoire de Biochimie (URA 1130 du CNRS), Département de Biologie Moléculaire et Structurale, Grenoble, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Issartel
authors.forename: A
authors.initials: A
authors.lastname: Dupuis
authors.forename: J
authors.initials: J
authors.lastname: Garin
authors.forename: J
authors.initials: J
authors.lastname: Lunardi
authors.forename: L
authors.initials: L
authors.lastname: Michel
authors.forename: P V
authors.initials: PV
authors.lastname: Vignais
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010085:Oxidative Phosphorylation; D006180:Proton-Translocating ATPases / Q000378:metabolism*
chemical_list: D006180:Proton-Translocating ATPases