title: Inhibition of Zn(2+)-dependent ATPase in prostasome membrane by nonsaturated, long-chain fatty acids.
abstract: Arachidonic and oleic acids, opposite to stearic and palmitic acids, at concentrations near 10(-5) mol/l markedly inhibited Zn(2+)-dependent ATPase in human prostasome membranes. Arachidonic acid was somewhat more potent as inhibitor than oleic acid and the involvement of the metabolites of arachidonic acid cascade was less probable. Deoxycholate, an anionic biological detergent, produced a similar inhibitory effect although at a much higher concentration. The restraining role of nonsaturated, long-chain fatty acids on sperm motility in human semen is discussed in terms of their established inhibitory action on prostasome ATPase systems.
authors.affiliation: Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Ronquist
authors.forename: G
authors.initials: G
authors.lastname: Frithz
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000502:physiology*; D006801:Humans; D007425:Intracellular Membranes / Q000201:enzymology; D008297:Male; D012661:Semen / Q000201:enzymology*; D013081:Sperm Motility; D015032:Zinc / Q000502:physiology*
chemical_list: D005231:Fatty Acids, Unsaturated; D000251:Adenosine Triphosphatases; D015032:Zinc