Metabolism of subcutaneous administered indium arsenide in the hamster.
Indium arsenide (InAs) is partially dissociated in vivo to form inorganic arsenic and indium and excreted into the urine and feces. InAs dissolves slowly over time with deposits at the site of injection. Results of this study demonstrated that the principal metabolite of arsenic in the urine of hamsters was dimethylated arsenic (DMA). Inorganic arsenic and DMA accumulated in the fur, but the concentrations of indium were very low in this matrix. Urine and feces were the principal routes of elimination from the body. Analysis of tissues for arsenic demonstrated as concentrations in the parts per billion range. Results of these studies indicate that InAs is dissociated in vivo with release of both the indium and arsenic moieties to target tissues.
Yamauchi
H
H
University Program in Toxicology, University of Maryland School of Medicine, Baltimore 21201.
Takahashi
K
K
Yamamura
Y
Y
Fowler
B A
BA
D000818:Animals; D001151:Arsenic / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001152:Arsenicals; D006224:Cricetinae; D005243:Feces / Q000737:chemistry; D007204:Indium / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007279:Injections, Subcutaneous; D008297:Male; D014018:Tissue Distribution
D001152:Arsenicals; D007204:Indium; C076773:indium arsenide; D001151:Arsenic