The nucleus ambiguus region participates in arterial pressure regulation.
Bilateral microinjections of lidocaine into the nucleus ambiguus produced a significant increase of mean arterial pressure. Electrical stimulation of the nucleus ambiguus produced pressor and bradycardic responses, which are abolished by injection of lidocaine into the rostral ventrolateral medulla. These data indicate that the pressor and bradycardic responses produced by electrical stimulation of the nucleus ambiguus depend on the integrity of the rostral ventrolateral medulla. We conclude that the nucleus ambiguus region is involved in the central neural control of arterial pressure through a possible neuronal inhibitory projection to the rostral ventrolateral medulla.
Machado
B H
BH
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242.
Brody
M J
MJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004558:Electric Stimulation; D006706:Homeostasis; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques
D008012:Lidocaine