De novo complex chromosome rearrangement in identical twins with multiple congenital anomalies.
A de novo and apparently balanced complex chromosome rearrangement (CCR) was found in monozygotic (MZ) twin infants with multiple congenital anomalies. The rearrangement involved 4 chromosomes with 6 breakpoints including 2p23, 2q13, 2q21.1, 3p23, 11q13.1, and 12q24.1. This seems to be the first report of a CCR in MZ twins. The relationship between this chromosome abnormality and MZ twinning is discussed.
Wakita
Y
Y
Department of Pediatrics, Okayama University Medical School, Japan.
Narahara
K
K
Tsuji
K
K
Yokoyama
Y
Y
Ninomiya
S
S
Murakami
R
R
Kikkawa
K
K
Seino
Y
Y
D000015:Abnormalities, Multiple / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic; D014430:Twins, Monozygotic / Q000235:genetics*