title: Lifetime prevalence of major depression and its effect on treatment outcome in obese type II diabetic patients.
abstract: OBJECTIVE
  To assess the lifetime prevalence of major depression (MD) and its relation to glycemic control among a group of non-insulin-dependent (type II) diabetic subjects seeking obesity treatment and to determine whether a history of MD affected response to treatment.
  
  
  METHODS
  Sixty-six obese subjects with type II diabetes (22 men, 44 women) completed the Inventory to Diagnose Depression-Lifetime Version before a 52-wk behavioral weight-control program. Weight, glycosylated hemoglobin, fasting blood glucose, and mood were assessed at pre- and posttreatment.
  
  
  RESULTS
  Thirty-two percent of the subjects reported a history of MD. Neither a history of MD nor current depressive symptoms were associated with pretreatment glycemic control. However, a history of MD was related to treatment attrition (52.4 vs. 22.2%, P = 0.03). Subjects with and without a history of MD showed comparable improvements in weight, glycemic control, and mood.
  
  
  CONCLUSIONS
  A history of MD among type II diabetic patients seeking obesity treatment was not related to pretreatment glycemic control but was associated with higher rates of attrition from treatment. Individuals with a history of MD who completed the program did not differ from those with no history of MD in response to treatment.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: M D
authors.initials: MD
authors.lastname: Marcus
authors.forename: R R
authors.initials: RR
authors.lastname: Wing
authors.forename: J
authors.initials: J
authors.lastname: Guare
authors.forename: E H
authors.initials: EH
authors.lastname: Blair
authors.forename: A
authors.initials: A
authors.lastname: Jawad
mesh_terms: D000328:Adult; D000368:Aged; D001521:Behavior Therapy; D001786:Blood Glucose / Q000378:metabolism; D003866:Depressive Disorder / Q000150:complications* / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000523:psychology* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000523:psychology* / Q000628:therapy; D003927:Diet, Diabetic; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D015995:Prevalence; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin