Immunology for the otolaryngic allergist.
An understanding of immunology is imperative for the practitioner of otolaryngic allergy. Figure 9 provides an overview of the allergic reaction. Complex immunologic mechanisms involving cellular and humoral elements are involved in allergic reactions. The primary cells of the immune response are lymphocytes, macrophages, eosinophils, mast cells, and basophils. Humoral immunity involves five classes of immunoglobulin: IgM, IgA, IgD, IgG, and IgE. Preformed (eg, histamine) and newly formed mediators (eg, prostaglandins, leukotrienes), interleukins, and the complement chain (classical and alternative pathways) are involved in various types of allergic reactions.
Trotsky
M
M
University of Nebraska School of Medicine, Omaha.
D000917:Antibody Formation / Q000276:immunology; D015550:Cell Degranulation / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D007111:Immunity, Cellular / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D007167:Immunotherapy; D007378:Interleukins / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D010038:Otorhinolaryngologic Diseases / Q000276:immunology* / Q000628:therapy
D007136:Immunoglobulins; D007378:Interleukins; D003165:Complement System Proteins