title: T-cell receptor gamma-delta positive lymphocytes in synovial membrane.
abstract: The distribution of T-lymphocytes expressing CD3 and T-cell receptor gamma-delta (T gamma/delta) has been examined by immunocytochemistry in the synovial membrane of eight patients with inflammatory arthritis (six rheumatoid arthritis, two spondyloarthritis) and eight with non-inflammatory arthritis (four osteoarthritis, four post-traumatic arthritis). T gamma/delta cells were present in eight out of eight inflammatory arthritis synovial membranes, but in only one out of eight non-inflammatory membranes (P less than 0.005). The mean T gamma/delta percentage (of total T-cells) in inflammatory arthritis was 14% (range 7-25%). T gamma/delta cells were found mainly in the transitional area of the synovial membrane with a scattered distribution as single cells or couplets. No relation was found between the presence and percentage of T gamma/delta cells and disease duration or steroid treatment.
authors.affiliation: University of Bologna, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Meliconi
authors.forename: M
authors.initials: M
authors.lastname: Uguccioni
authors.forename: A
authors.initials: A
authors.lastname: D'Errico
authors.forename: A
authors.initials: A
authors.lastname: Cassisa
authors.forename: L
authors.initials: L
authors.lastname: Frizziero
authors.forename: A
authors.initials: A
authors.lastname: Facchini
mesh_terms: D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis*; D013583:Synovial Membrane / Q000378:metabolism*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta