title: Salvage surgery by composite resection for epidermoid carcinoma of the tonsillar region.
abstract: Radiation therapy has usually been used as the primary treatment of squamous cell carcinoma of the posterior aspect of the oral cavity and the lateral aspect of the oropharyngeal walls. However, local failure occurs in a certain number of cases, depending on the initial tumor stage. One hundred thirty-four composite resections (transmaxillary buccopharyngectomies) have been performed as a salvage treatment at the Institut Gustave-Roussy, Villejuif, France, from January 1, 1976, through December 31, 1985, for local failure of epidermoid carcinomas treated initially by radiotherapy. Average time between primary irradiation and salvage surgery was 18 months. Most of the patients underwent some kind of supraomohyoid neck dissection. A myocutaneous flap was used in 18% of cases, which significantly reduced the rate of local complications. The nasogastric tube and the tracheostomy cannula were removed after a median delay of 23 days and 24 days, respectively. Early postoperative local complications occurred in 45% of cases; most of them were minor. A new locoregional recurrence occurred in approximately half of the patients and was usually fatal. Overall survival after salvage surgery was 34% at 3 years and 23% at 5 years. The only statistically significant prognostic factor was the adequacy of surgical margins.
authors.affiliation: Department of Chirurgie-Otorhinolaryngology and Cervicofacial Surgery, Institut Gustave-Roussy, Villejuif, France.
authors.forename: L
authors.initials: L
authors.lastname: Pacheco-Ojeda
authors.forename: P
authors.initials: P
authors.lastname: Marandas
authors.forename: M
authors.initials: M
authors.lastname: Julieron
authors.forename: A
authors.initials: A
authors.lastname: Lusinchi
authors.forename: G
authors.initials: G
authors.lastname: Mamelle
authors.forename: B
authors.initials: B
authors.lastname: Luboinski
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010611:Pharyngectomy / Q000379:methods; D016879:Salvage Therapy; D016019:Survival Analysis; D014067:Tonsillar Neoplasms / Q000532:radiotherapy / Q000601:surgery*