[Serologically detected HY antigen and its regulation].
The serologically detected, male predominant s HY Ag is a surface glycoprotein. The structural gene would be located on the 6th chromosome and regulated by gonosomal genes. The presence of testes (or testicular remenants) is linked to the s HY antigen expression in most abnormalities of sexual differentiation. However, the basal s HY Ag value is sometimes increased in the absence of any testicular tissue, as in virilized females (21-hydroxylase deficiency, idiopathic or ovarian hirsutism). Homogametic sex s HY Ag may increase to heterogametic sex values under the action of androgens in mammals and that of oestrogens in birds.
Amice
J
J
Service de Cytologie, Cytogénétique et Biologie de la Reproduction, CHU Morvan, Brest.
Amice
V
V
Kerlan
V
V
Bercovici
J P
JP
D005260:Female; D005786:Gene Expression Regulation; D006059:Gonadal Dysgenesis / Q000235:genetics; D006182:H-Y Antigen / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D008297:Male; D013737:Testis / Q000502:physiology*
D006182:H-Y Antigen
L'antigène HY sérologiquement défini et sa régulation.