Mineral metabolism in erythrocytes from patients with cystic fibrosis.
In patients with cystic fibrosis plasma concentrations of Zn and Mg were unchanged, plasma Ca concentrations were somewhat decreased, but plasma Fe concentrations were drastically reduced; the ratio Cu/Fe in plasma was increased. The Mg and Zn contents of erythrocytes from patients were unchanged. Therefore, the Mg and Zn content of erythrocytes cannot serve for the detection of patients with cystic fibrosis and their heterozygotes, as has been suggested. Cl(-)-dependent Mg2+ efflux from Mg(2+)-loaded erythrocytes was not affected in cystic fibrosis. Na(+)-dependent Mg2+ efflux was increased only in erythrocytes from patients with the most severe clinical symptoms.
Vormann
J
J
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin.
Günther
T
T
Magdorf
K
K
Wahn
U
U
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000097:blood; D003300:Copper / Q000097:blood; D003550:Cystic Fibrosis / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D008903:Minerals / Q000097:blood*; D015032:Zinc / Q000097:blood
D002712:Chlorides; D008903:Minerals; D003300:Copper; D007501:Iron; D008274:Magnesium; D015032:Zinc; D002118:Calcium