Hematologic alterations in adult cats fed 6 or 12% propylene glycol.
Cat foods containing propylene glycol (PG) induce Heinz body formation in feline erythrocytes. To further study the hematologic importance of dietary PG, 21 adult cats were allotted to 3 groups of 7 each and fed diets containing 0, 6, or 12% PG on a dry-weight basis. Cats fed PG had a dose-related increase in Heinz bodies within 2 weeks, and the increase persisted throughout the study. Although only slight changes occurred in PCV, hemoglobin concentration, and RBC count, punctate reticulocytes were significantly increased in the group fed 12% PG. Mean RBC survival was decreased in the groups fed 6 or 12% PG by 30 and 55%, respectively, compared with the control group. These data indicate that PG-containing diets cause a dose-dependent erythrocyte destruction, even when fed at concentrations as low as 6%.
Bauer
M C
MC
Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108.
Weiss
D J
DJ
Perman
V
V
D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D001853:Bone Marrow / Q000187:drug effects; D002415:Cats / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004435:Eating; D004906:Erythrocyte Count / Q000662:veterinary; D004909:Erythrocyte Indices / Q000662:veterinary; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006366:Heinz Bodies; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology*; D011897:Random Allocation; D012156:Reticulocytes / Q000187:drug effects; D013047:Specific Pathogen-Free Organisms
D006454:Hemoglobins; D011409:Propylene Glycols; D019946:Propylene Glycol