title: Lysosomal enzymic activity of astroglial cells.
abstract: Using human and rat Glioma cell lines and mouse astrocytes prepared from newborn mice, lysosomal enzymatic activity, which is closely related with phagocytic activity, was assayed by spectrophotometric measurement of p-nitrophenol liberated from the relevant substrate. Lysosomal N-acetyl-beta-D-glucosaminidase and acid phosphatase activity was detected in neoplastic astrocytes at a level of enzymatic activity equal to that of monocyte/macrophage cell lines in certain glioma cells. From the implication of this data, it is suspected that astrocytes may function as phagocytic cells at inflammatory brain lesions.
authors.affiliation: Department of Neurological Surgery, University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nitta
authors.forename: K
authors.initials: K
authors.lastname: Okumura
authors.forename: K
authors.initials: K
authors.lastname: Sato
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000201:enzymology* / Q000502:physiology; D002460:Cell Line; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis
chemical_list: D000135:Acid Phosphatase; D000118:Acetylglucosaminidase