Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic.
Mastalgia commonly presents to medical practitioners. The majority of patients can be managed by exclusion of cancer and reassurance. In some the severity of pain affects the quality of life and drug treatment should be considered. Since its inception 324 patients with cyclical mastalgia and 90 with non-cyclical mastalgia have received a therapeutic trial of drug treatment in the Cardiff Mastalgia Clinic. Overall 92% of those with cyclical mastalgia and 64% with non-cyclical mastalgia obtained a clinically useful response to therapy. Danazol was the most effective drug, with bromocriptine and evening primrose oil having equivalent efficacy. Many fewer adverse events were complained of by patients treated with evening primrose oil than danazol or bromocriptine.
Gateley
C A
CA
University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff.
Miers
M
M
Mansel
R E
RE
Hughes
L E
LE
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001941:Breast Diseases / Q000188:drug therapy*; D001971:Bromocriptine / Q000627:therapeutic use*; D003613:Danazol / Q000627:therapeutic use*; D005228:Fatty Acids, Essential / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008041:Linoleic Acids; D031665:Oenothera biennis; D010146:Pain / Q000188:drug therapy*; D010507:Periodicity; D010938:Plant Oils; D016896:Treatment Outcome; D017965:gamma-Linolenic Acid
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D010938:Plant Oils; D001971:Bromocriptine; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D003613:Danazol