title: Production and reversibility of right ventricular hypertrophy and right heart failure in dogs.
abstract: Combined heart-lung transplantation has been used for end-stage primary pulmonary hypertension. Experience with single-lung transplantation for other conditions suggested that associated severe right ventricular dysfunction resulting from increased afterload would recover after placement of a satisfactory lung allograft. Early experience with the application of single-lung transplantation for pulmonary hypertension supports this contention. We devised a reversible canine model of chronic progressive pressure-overloaded right heart failure by pulmonary artery banding to study the echocardiographic, hemodynamic, and pathological reversibility of the failing right heart. Clinical right heart failure was defined as the development of ascites and pleural effusions. Right heart failure developed in 23 dogs 67 to 348 days after banding, and they were divided into two groups to determine its early and long-term effects. Group 1 dogs (n = 11) were either sacrificed immediately after the onset of right heart failure (n = 5) or unbanded (n = 6); group 2 dogs (n = 12) were maintained in right heart failure for 3 months and then either sacrificed (n = 6) or unbanded. Unbanded dogs in both groups were observed for 4 additional months before sacrifice. A control group of 6 normal dogs was sacrificed for pathological comparisons. After unbanding, the right ventricular systolic pressure fell from 97 +/- 17 mm Hg (group 1) and 88 +/- 31 mm Hg (group 2) to 44 +/- 11 mm Hg and 47 +/- 13 mm Hg, respectively. Despite this persistent gradient across the pulmonary artery, echocardiographic and hemodynamic measures of right ventricular function returned to normal, albeit more slowly in the group 2 dogs.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Thoracic Surgery, Toronto General Hospital, Ontario, Canada.
authors.forename: C M
authors.initials: CM
authors.lastname: Hsieh
authors.forename: G J
authors.initials: GJ
authors.lastname: Mishkel
authors.forename: P F
authors.initials: PF
authors.lastname: Cardoso
authors.forename: H
authors.initials: H
authors.lastname: Rakowski
authors.forename: S C
authors.initials: SC
authors.lastname: Dunn
authors.forename: J
authors.initials: J
authors.lastname: Butany
authors.forename: R D
authors.initials: RD
authors.lastname: Weisel
authors.forename: G A
authors.initials: GA
authors.lastname: Patterson
authors.forename: J D
authors.initials: JD
authors.lastname: Cooper
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006332:Cardiomegaly / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D004452:Echocardiography; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006339:Heart Rate; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology*; D016278:Ventricular Function, Right / Q000502:physiology*