Phase I trial of a cisplatin-albumin complex for the treatment of cancer of the head and neck.
1. A phase I trial of a cisplatin-albumin complex for the treatment of end-stage squamous cell carcinoma of the head and neck is reported. The complex was prepared by overnight incubation of cisplatin with human albumin at 37 degrees C. This resulted in more than 98% of the drug being bound to protein at the start of treatment. The patients were either unable to continue with or had refused conventional therapy with cisplatin. 2. The trial began at a dose of 100 mg cisplatin m-2 and was increased in 25 mg m-2 increments to 650 mg m-2. Despite the absence of the customary protective measures of pre-hydration and anti-emetic treatment no serious toxicity was encountered. 3. Unbound plasma platinum concentrations were lower than after conventional cisplatin treatment but total plasma platinum and tumour platinum concentrations were much higher. Urinary excretion of platinum was low and the incidence of nephrotoxicity was greatly diminished. Two responses were seen (one complete and one partial) in 38 patients treated and the median survival time was 109 days, compared with 151 days for patients treated conventionally with cisplatin and 56 days for untreated patients. 4. The complex is not as effective as conventional cisplatin therapy but is much less toxic, offers improved quality of life during treatment and may prove to be of benefit in patients who could not otherwise be treated.
Holding
J D
JD
Department of Pharmacology and Therapeutics, University of Liverpool.
Lindup
W E
WE
van Laer
C
C
Vreeburg
G C
GC
Schilling
V
V
Wilson
J A
JA
Stell
P M
PM
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D004339:Drug Compounding; D004341:Drug Evaluation; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D010984:Platinum / Q000378:metabolism; D012709:Serum Albumin / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use
D012709:Serum Albumin; D010984:Platinum; D002945:Cisplatin