title: Low-dose oral methotrexate as second-line therapy for persistent trophoblast after conservative treatment of ectopic pregnancy.
abstract: The aim of this study was to evaluate the efficacy of methotrexate as second-line treatment for ectopic pregnancy. Oral methotrexate was used in 15 patients with evidence of persistent trophoblast after conservative laparoscopic surgery for tubal pregnancy. The treatment was successful in 14 of 15 cases, and the mean time for decline of serum hCG to nonpregnant levels was 24 days. In the remaining case, hCG continued to rise. Side effects were noticed, even at a low dosage, but only in those subjects not receiving citrovorum rescue. As an alternative to a second operation, oral methotrexate appears to be an effective and well-tolerated therapy for persistent trophoblast.
authors.affiliation: Department of Obstetrics and Gynecology, University of Göteborg, Sahlgrenska Hospital, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Bengtsson
authors.forename: I
authors.initials: I
authors.lastname: Bryman
authors.forename: J
authors.initials: J
authors.lastname: Thorburn
authors.forename: B
authors.initials: B
authors.lastname: Lindblom
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy* / Q000601:surgery
chemical_list: D006063:Chorionic Gonadotropin; D008727:Methotrexate