[The comparison of absorptive routes of intraperitoneal infusion with cisplatin in dogs].
Dogs weighing between 10 and 15 kg were used, and cisplatin was given at a dose of 2 mg/kg. The dogs were infused ip with either 100 ml (A groups) or 200 ml (B groups) of physiological salt solution containing cisplatin. The cisplatin concentrations in serum (peripheral and portal blood), and liver tissues were measured with limited filtration using MPS of AMICON (free-CDDP). The total CDDP concentration was also determined. Blood was collected at 30 minutes, and 1, 2, 3, 4, 5 and 6 hours after ip administration. The following results were obtained: 1) A high concentration of free-CDDP (AUC) was observed in the portal blood of A groups. 2) Peripheral serum level (total-CDDP) was increased in the B groups. 3) Total CDDP level within the liver tissues was higher in the A groups. It is concluded that ip cisplatin therapy with moderate volume solution may be effective for liver metastasis of gastric cancer for delivery to the liver tissue.
Namatame
K
K
Dept. of Surgery, Showa University Fujigaoka Hospital.
Kou
Y
Y
Sasaki
E
E
Nakayoshi
A
A
D000042:Absorption; D000818:Animals; D002408:Catheters, Indwelling; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D016503:Drug Delivery Systems; D007263:Infusions, Parenteral; D008099:Liver / Q000378:metabolism*; D011168:Portal System / Q000378:metabolism
D002945:Cisplatin