Interactive effects of ethanol on benzodiazepines levels in blood and brain of rat.
Effects of ethanol administration on triazolam, estazolam, diazepam, and chlordiazepoxide levels in blood and brain were investigated using rats. The brain level of triazolam was significantly increased by the concomitant oral administration of ethanol though the blood level was scarcely influenced. Estazolam levels in the blood and brain tended to be markedly raised by the ethanol administration. Diazepam levels in the blood and brain showed a tendency to be a little increased by the ethanol administration. Chlordiazepoxide levels in the blood and brain were scarcely influenced by the ethanol treatment. It was suggested that reinforcement effect of ethanol on the central nervous system depressant actions of triazolam and estazolam might appear by potentiation.
Moriya
F
F
Department of Legal Medicine, Okayama University Medical School, Japan.
Ishizu
H
H
D000284:Administration, Oral; D000818:Animals; D001569:Benzodiazepines / Q000097:blood / Q000493:pharmacokinetics*; D001923:Brain Chemistry / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000097:blood / Q000493:pharmacokinetics; D003975:Diazepam / Q000097:blood / Q000493:pharmacokinetics; D004347:Drug Interactions; D004949:Estazolam / Q000097:blood / Q000493:pharmacokinetics; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014229:Triazolam / Q000097:blood / Q000493:pharmacokinetics
D001569:Benzodiazepines; D014229:Triazolam; D004949:Estazolam; D000431:Ethanol; D002707:Chlordiazepoxide; D003975:Diazepam