Role of foods in sporadic listeriosis. I. Case-control study of dietary risk factors. The Listeria Study Group.
OBJECTIVE
To identify dietary risk factors for sporadic listeriosis.


METHODS
Case-control study with blinded telephone interviews.


METHODS
Multistate population of 18 million persons, November 1988 through December 1990.


METHODS
One hundred sixty-five patients with culture-confirmed listeriosis and 376 control subjects matched for age, health care provider, and immunosuppressive condition.


RESULTS
The annual incidence of invasive listeriosis was 7.4 cases per million population; 23% of the infections were fatal. Cases were more likely than matched controls to have eaten soft cheeses (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.4 to 4.8; P = .002) or food purchased from store delicatessen counters (OR, 1.6; 95% CI, 1.0 to 2.5; P = .04); 32% of sporadic disease could be attributed to eating these foods. Sixty-nine percent of cases in men and nonpregnant women occurred in cancer patients, persons with the acquired immunodeficiency syndrome, organ transplant recipients, or those receiving corticosteroid therapy. Among these immunosuppressed patients, eating undercooked chicken also increased the risk of listeriosis (OR, 3.3; 95% CI, 1.2 to 9.2; P = .02).


CONCLUSIONS
Foodborne transmission may account for a substantial portion of sporadic listeriosis. Prevention efforts should include dietary counseling of high-risk patients and continued monitoring of food production.
Schuchat
A
A
Meningitis and Special Pathogens Branch, Centers for Disease Control, Atlanta, Ga 30333.
Deaver
K A
KA
Wenger
J D
JD
Plikaytis
B D
BD
Mascola
L
L
Pinner
R W
RW
Reingold
A L
AL
Broome
C V
CV
D016022:Case-Control Studies; D005502:Food; D005516:Food Microbiology; D006801:Humans; D007407:Interviews as Topic; D008089:Listeria monocytogenes / Q000302:isolation & purification; D008088:Listeriosis / Q000453:epidemiology / Q000382:microbiology*; D016017:Odds Ratio; D011159:Population Surveillance; D012044:Regression Analysis; D012307:Risk Factors; D014481:United States / Q000453:epidemiology