title: Nitrosamine excretion in patients with continent ileal reservoirs for urinary diversion.
abstract: Adenocarcinomas are a recognized complication following ureterosigmoidostomy for which the endogenous formation of N-nitroso compounds may be a risk factor. As an alternative means of urinary diversion, the continent ileal reservoir has recently been developed. Microbiological and chemical investigations on the urine of patients with an ileal reservoir showed the presence of bacteria, nitrate, nitrite and N-nitrosamines formed endogenously in the ileal pouch. The role of nitrosamines in carcinogenesis in these patients as a late stage complication resulting from the use of a continent ileal reservoir is discussed.
authors.affiliation: Department of Urology, University of Heidelberg, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Gröschel
authors.forename: G
authors.initials: G
authors.lastname: Riedasch
authors.forename: T
authors.initials: T
authors.lastname: Kälble
authors.forename: A R
authors.initials: AR
authors.lastname: Tricker
mesh_terms: D000328:Adult; D000368:Aged; D001419:Bacteria / Q000378:metabolism; D006801:Humans; D007082:Ileum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000378:metabolism / Q000652:urine; D009573:Nitrites / Q000378:metabolism / Q000652:urine; D009602:Nitrosamines / Q000378:metabolism / Q000652:urine*; D016476:Urinary Reservoirs, Continent; D014556:Urine / Q000382:microbiology
chemical_list: D009566:Nitrates; D009573:Nitrites; D009602:Nitrosamines