[Quality assessment of ginseng by chemical fuzzy pattern recognition].
Water and liquor extracts of ginseng simulating its habitual preparations used in the practice of traditional Chinese medical science were prepared from 25 samples, and data reflecting its chemical constituents as a whole were obtained by ultraviolet and visible spectrophotometry (UV-Vis), high performance liquid chromatography (HPLC), and emission spectroscopy with inductively coupled plasma source (ICP). Antifatigue, antidiuretic, and macrophage phagocytosis experiments were carried out to determine the pharmacologic actions of the extracts. Results obtained with the extracts on mice were compared mutually and with those obtained on placebo-treated ones in the respective pharmacologic experiments. Based on the results of the three pharmacologic experiments, features were selected from among the chemical data and fuzzy equations formulated hereby were solved to ascertain the effective constituents with different weights and their compatibility. Finally, correlation analysis was carried out, and a new scheme for the quality assessment of ginseng has been worked out. The methodology proposed is of general significance to the formulation of quality assessment schemes for Chinese traditional medicines and the ascertainment of their bioactive constituents.
Bi
K S
KS
Shenyang College of Pharmacy.
Wang
X
X
Luo
X
X
D000818:Animals; D002241:Carbohydrates / Q000032:analysis; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D008433:Mathematics; D051379:Mice; D005894:Panax / Q000737:chemistry; D010363:Pattern Recognition, Automated; D010946:Plants, Medicinal; D011786:Quality Control; D012503:Saponins / Q000032:analysis
D002241:Carbohydrates; D004365:Drugs, Chinese Herbal; D012503:Saponins