Assessment of antimicrobial treatment of denture stomatitis using an in vivo replica model system: therapeutic efficacy of an oral rinse.
Five denture stomatitis patients demonstrating Candida albicans on both maxillary dentures and palates volunteered to test the effects of Peridex oral rinse in treating their oral disease. They used Peridex rinse both as a mouthrinse and as a denture soak for a period of 24 days. Agar replicas of the tissue-fitting surfaces of the maxillary dentures revealed elimination of C. albicans. Significant decreases in palatal inflammation were also noted, although some inflammation was still evident. Several weeks after the termination of Peridex oral rinses, inflammation increased as concentrations of C. albicans on the denture surface returned to pretreatment levels. A marked similarity in the site-specific localization of this yeast species on the denture was noted before and after Peridex rinse treatment.
Lal
K
K
Department of Oral Biology and Pathology, State University of New York, School of Dental Medicine, Stony Brook.
Santarpia
R P
RP
Pollock
J J
JJ
Renner
R P
RP
D000180:Acrylic Resins; D000362:Agar; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology; D002180:Candidiasis, Oral / Q000188:drug therapy*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003819:Denture Bases; D003820:Denture Cleansers; D003824:Denture, Complete; D004463:Ecology; D006801:Humans; D008828:Microbiological Techniques; D009067:Mouthwashes; D010159:Palate / Q000382:microbiology; D012008:Recurrence; D013282:Stomatitis, Denture / Q000188:drug therapy* / Q000382:microbiology
D000180:Acrylic Resins; D003820:Denture Cleansers; D009067:Mouthwashes; D000362:Agar; C010882:chlorhexidine gluconate; D002710:Chlorhexidine