Homeostasis as regulated by activated macrophage. III. Protective effect of LPSw (lipopolysaccharide (LPS) of wheat flour) on gastric ulcer in mice as compared with those of other LPS from various sources.
Protective effect of lipopolysaccharide (LPS) from various sources on gastric ulcer has been examined in mice using parenteral as well as oral route. Ulcer is induced by indomethacin, stress or alcohol. LPS was prepared from 6 species of bacteria (Escherichia coli, Pantoea agglomerans, Serratia ficaria, Enterobacter cloacae, Bordetella pertussis, Alcaligenes faecalis) and from wheat flour. When administered intravenously, LPS of Pantoea agglomerans was the most effective among other LPS examined. Lipopolysaccharide of wheat flour (LPSw) showed a significantly protective effect by the oral route, especially when given ad libitum in drinking water to mice.
Inagawa
H
H
Biotechnology Research Center, Teikyo University, Kanagawa, Japan.
Saitoh
F
F
Iguchi
M
M
Nishizawa
T
T
Okutomi
T
T
Morikawa
A
A
Soma
G I
GI
Mizuno
D
D
D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005433:Flour; D006706:Homeostasis / Q000502:physiology*; D008070:Lipopolysaccharides / Q000627:therapeutic use*; D008262:Macrophage Activation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D013276:Stomach Ulcer / Q000517:prevention & control*; D014908:Triticum
D000897:Anti-Ulcer Agents; D008070:Lipopolysaccharides