Spontaneous recovery from Friend retrovirus-induced leukemia. Mapping of the Rfv-2 gene in the Q/TL region of mouse MHC.
The Rfv-2 gene that influences the rate of spontaneous recovery from erythroleukemia induced by a low dose of Friend retrovirus complex was mapped to the Q/TL region of mouse MHC. Rfv-2 was physically and functionally distinct from the I-A-linked Ir gene that has been shown to control the responsiveness of Th cells to the envelope glycoprotein of Friend murine leukemia helper virus. The negative effect of the Rfv-2s allele was overcome by the B10.D2-H-2dm1 mutation of the D-L genes of H-2, suggesting functional similarities between the D-L and Q/TL genes in influencing resistance against Friend murine leukemia retrovirus complex infection or possible modification of Q/TL expression by genes in the D-L region.
Miyazawa
M
M
Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infections Diseases, Hamilton, MT 59840.
Nishio
J
J
Wehrly
K
K
David
C S
CS
Chesebro
B
B
D000818:Animals; D002874:Chromosome Mapping; D005622:Friend murine leukemia virus; D005805:Genes, MHC Class I; D008040:Genetic Linkage; D007942:Leukemia, Experimental / Q000235:genetics*; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology