title: Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.
abstract: Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.
authors.affiliation: Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
authors.forename: S M
authors.initials: SM
authors.lastname: Wolinsky
authors.forename: C M
authors.initials: CM
authors.lastname: Wike
authors.forename: B T
authors.initials: BT
authors.lastname: Korber
authors.forename: C
authors.initials: C
authors.lastname: Hutto
authors.forename: W P
authors.initials: WP
authors.lastname: Parks
authors.forename: L L
authors.initials: LL
authors.lastname: Rosenblum
authors.forename: K J
authors.initials: KJ
authors.lastname: Kunstman
authors.forename: M R
authors.initials: MR
authors.lastname: Furtado
authors.forename: J L
authors.initials: JL
authors.lastname: Muñoz
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000151:congenital / Q000382:microbiology / Q000635:transmission*; D000595:Amino Acid Sequence; D001483:Base Sequence; D005260:Female; D005838:Genotype; D006031:Glycosylation; D015488:HIV Antigens / Q000235:genetics; D015699:HIV Envelope Protein gp120 / Q000235:genetics / Q000276:immunology; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007223:Infant; D008431:Maternal-Fetal Exchange; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012641:Selection, Genetic; D016415:Sequence Alignment
chemical_list: D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D009838:Oligodeoxyribonucleotides