title: The effect of physical training on rat calf muscle, oxygen tension, blood flow, metabolism and function in an animal model of chronic occlusive peripheral vascular disease.
abstract: The effect of treadmill physical training (PT) on rat gastrocnemius/plantaris muscle after bilateral femoral artery ligation was investigated. To enable a comparison to be made between the susceptibility of muscles with restricted blood flow and normally perfused skeletal muscle to PT, animals without ligated femoral arteries also underwent PT. PT increased the oxidative capacity of the gastrocnemius/plantaris muscle, as judged by the activity of citrate synthase, and reduced muscle fatigue in both groups of animals. Exercise also tended to lower the activity of a marker enzyme for glycolysis, glyceraldehyde-phosphate dehydrogenase in all animals, although this only reached the level of statistical significance in the animals with ligated femoral arteries. In the animals with restricted muscle blood flow, PT increased gastrocnemius skeletal muscle blood flow and pO2 and prolonged the time taken to attain maximum muscle twitch tension. The results indicate a great susceptibility of hindlimb skeletal muscles of rats with ligated femoral arteries to PT. They also suggest that the beneficial effect of PT observed in man with chronic occlusive arterial disease (COAD) may result both from an increase in muscle blood flow and from an enhanced mitochondrial respiratory activity in the afflicted muscle.
authors.affiliation: BEECHAM-WUELFING Research Laboratories, Gronau (Leine), Germany.
authors.forename: C D
authors.initials: CD
authors.lastname: Nicholson
authors.forename: D
authors.initials: D
authors.lastname: Angersbach
authors.forename: R
authors.initials: R
authors.lastname: Wilke
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005263:Femoral Artery / Q000601:surgery; D006614:Hindlimb; D008026:Ligation; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D016491:Peripheral Vascular Diseases / Q000378:metabolism* / Q000503:physiopathology; D010805:Physical Conditioning, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow
chemical_list: D010100:Oxygen