Promotion as a factor in carcinogenesis.
Promotion is any factor which results in the increased cellular replication of initiated or transformed cells. We argue that cytotoxicity is not a necessary component of promotion and that, therefore, the existence of a threshold for promotion is unlikely.
Travis
C C
CC
Risk Analysis Section, Oak Ridge National Laboratory, TN 37831-6109.
Belefant
H
H
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008938:Mitosis; D016296:Mutagenesis; D009369:Neoplasms / Q000139:chemically induced*