title: Behavioral and trigeminal neuronal effects of rat brainstem-nanoinjected opiates.
abstract: Single injections of Met-enkephalin (ME; 27 rats) and artificial cerebrospinal fluid (ACF; 9 rats) in nucleus reticularis paragigantocellularis (PGC) and periaqueductal gray (PAG), and simultaneous conjoint PAG + PGC injections were made, and effects on facial responsiveness and caudal-trigeminal nuclear neuronal activity studied. It was found that all ME injections depressed the evoked excitatory neuronal and behavioral responses to noxious stimulation. Conjoint injections had apparently additive effects in comparison to single injection effects. Neither conjoint nor single injections had systematic effects on spontaneous neuronal activity. The ACF had no effects on any neuronal or behavioral activity.
authors.affiliation: Department of Psychology, Northwestern University, Evanston, IL 60208.
authors.forename: L Y
authors.initials: LY
authors.lastname: Xia
authors.forename: K H
authors.initials: KH
authors.lastname: Huang
authors.forename: J P
authors.initials: JP
authors.lastname: Rosenfeld
mesh_terms: D000758:Anesthesia; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001933:Brain Stem / Q000033:anatomy & histology; D004744:Enkephalin, Methionine / Q000008:administration & dosage / Q000494:pharmacology*; D006358:Hot Temperature; D007267:Injections; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects*; D010487:Periaqueductal Gray; D010812:Physical Stimulation; D011903:Raphe Nuclei; D051381:Rats; D011919:Rats, Inbred Strains; D014276:Trigeminal Nerve / Q000033:anatomy & histology / Q000187:drug effects*
chemical_list: D004744:Enkephalin, Methionine