Strategies towards a transgenic model of essential hypertension.
The generation of genetically modified animals by transgenic technology has proven to be a surprisingly versatile resource for researchers, providing an increasing number of new tools for biological investigation. As well as permitting the analysis of gene function and regulation in vivo, modifications of the techniques are being used to suppress or abolish the expression of specific genes, and further refinements have permitted the ablation of specific cell-types and the development of differentiated cell lines from tissue-specific tumours. In hypertension research, where many important questions have been frustratingly difficult to address by previously available methods, the advances afforded by transgenic studies have already been significant and are likely to be even more profound in the future. With the further development of these techniques, it may be possible to produce new and more representative models of essential hypertension.
Barrett
G L
GL
AFRC Centre for Genome Research, University of Edinburgh, U.K.
Mullins
J J
JJ
D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics*; D009320:Atrial Natriuretic Factor / Q000235:genetics; D005786:Gene Expression Regulation; D006973:Hypertension / Q000235:genetics*; D008957:Models, Genetic; D012083:Renin / Q000235:genetics
D000808:Angiotensinogen; D009320:Atrial Natriuretic Factor; D012083:Renin