title: In vivo measurement of the volume of distribution of water in cerebral grey matter: effects on the calculation of regional cerebral blood flow.
abstract: The present study was undertaken to determine the apparent value for the volume of distribution of water to be used in the dynamic/integral technique for generating functional CBF images. A value of 0.86 resulted in only a minor loss of accuracy compared to the more accurate (but time-consuming) dynamic only analysis, which incorporated the regionally fitted estimates of the volume of distribution of water. In contrast to the traditionally used in vitro value of 0.95, the value of 0.86 allows for the inclusion of a significant part of the washout phase in the integral analysis, thereby producing statistically improved CBF images.
authors.affiliation: MRC Cyclotron Unit, Hammersmith Hospital, London, U.K.
authors.forename: A A
authors.initials: AA
authors.lastname: Lammertsma
authors.forename: A J
authors.initials: AJ
authors.lastname: Martin
authors.forename: K J
authors.initials: KJ
authors.lastname: Friston
authors.forename: T
authors.initials: T
authors.lastname: Jones
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D001783:Blood Flow Velocity; D001834:Body Water / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes / Q000008:administration & dosage; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D010104:Oxygen Radioisotopes