Intrapocket chemotherapy in adult periodontitis using a new controlled-release insert containing ofloxacin (PT-01).
PT-01 is a newly developed water-soluble controlled-release insert containing ofloxacin (OFLX) as an antibacterial agent. The effect of PT-01 was evaluated by split-mouth application after oral hygiene instruction. No mechanical debridement was carried out during the experiment. PT-01 was applied once a week for 4 weeks in the periodontal pockets of 46 patients with adult periodontitis. The control insert without any antibacterial agent was applied in a selected pocket in a different quadrant for each patient. Clinical findings plaque index, PI; gingival index, GI; bleeding on probing, BOP; pus discharge, pus; and probing depth, PD at both PT-01 and control sites were measured at every visit for 4 weeks. Clinical findings were improved at both PT-01 and control sites, but the improvements were much more significant at PT-01 sites, in particular BOP and PD, than at control sites. PI was also significantly reduced at PT-01 sites. These results suggest that weekly application of PT-01 in the periodontal pocket has a significant effect on the resolution of periodontal inflammation and has an inhibitory effect on supragingival plaque deposition.
Yamagami
H
H
Division of Dentistry, Sakai Municipal Hospital, Osaka, Japan.
Takamori
A
A
Sakamoto
T
T
Okada
H
H
D000328:Adult; D000368:Aged; D003692:Delayed-Action Preparations; D003774:Dental Plaque Index; D004343:Drug Implants; D005260:Female; D005884:Gingival Hemorrhage / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D009910:Oral Hygiene; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy / Q000473:pathology; D010518:Periodontitis / Q000188:drug therapy* / Q000473:pathology; D013492:Suppuration
D003692:Delayed-Action Preparations; D004343:Drug Implants; D015242:Ofloxacin