title: Effects of celiprolol on cardiovascular reactivity to laboratory stressors in patients with hypertension.
abstract: An ideal antihypertensive drug should reduce blood pressure not only at rest but also during stressful situations. To test whether this criterion is fulfilled by celiprolol, a new beta 1-selective adrenergic blocker drug with peripheral vasodilating activity, we examined the effects of its oral administration on cardiovascular reactivity to laboratory stressors in 18 patients with essential hypertension, according to a placebo-controlled crossover design. In the 12 patients classified as "responders," celiprolol significantly reduced resting systolic and diastolic blood pressure (p less than 0.05 for both). Compared with placebo, celiprolol induced a blood pressure reduction from 179.4 +/- 16.9/119.5 +/- 12.4 mm Hg to 160.7 +/- 12.6/109.4 +/- 3.1 mm Hg during mental arithmetic; from 200.9 +/- 20.7/139.2 +/- 11.9 mm Hg to 184.1 +/- 16.4/127.6 +/- 12.1 mm Hg during handgrip test; from 212.8 +/- 18.5/126.2 +/- 14.2 mm Hg to 185.9 +/- 18.2/117.1 +/- 15.2 mm Hg during cycle ergometry. Our data suggest that in the majority of treated patients celiprolol is effective in reducing blood pressure not only at rest but also during a variety of stressful events, thereby ameliorating the impact of recurring stress-induced increases of blood pressure on the cardiovascular system.
authors.affiliation: Istituto di Patologia Speciale Medica, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cardillo
authors.forename: C
authors.initials: C
authors.lastname: Degen
authors.forename: F
authors.initials: F
authors.lastname: De Felice
authors.forename: G
authors.initials: G
authors.lastname: Folli
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D017272:Celiprolol; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology* / Q000523:psychology; D008297:Male; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D000959:Antihypertensive Agents; D011412:Propanolamines; D017272:Celiprolol