title: Circadian variation in total plasma tryptophan. Antidepressant treatment: drugs and phase advance.
abstract: The authors investigated hourly total plasma tryptophan concentrations over a 24 hour period in 3 patients with bipolar depression during 2 types of treatment: a phase advance process and conventional antidepressant therapy. Both treatment modalities increased the 24 hour mean tryptophan levels and the amplitude of circadian tryptophan concentrations. By contrast, in a previous study, moderately decreased tryptophan levels and a blunted amplitude in the circadian rhythm were observed in these same patients in a depressive phase.
authors.affiliation: Laboratoire de Biochimie, Hôpital Pasteur, Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: Candito
authors.forename: D
authors.initials: D
authors.lastname: Pringuey
authors.forename: A
authors.initials: A
authors.lastname: Iordache
authors.forename: E
authors.initials: E
authors.lastname: Souêtre
authors.forename: P
authors.initials: P
authors.lastname: Chambon
authors.forename: G
authors.initials: G
authors.lastname: Darcourt
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008803:Mianserin / Q000627:therapeutic use*; D008875:Middle Aged; D014364:Tryptophan / Q000097:blood*; D014745:Viloxazine / Q000627:therapeutic use*
chemical_list: D008803:Mianserin; D014745:Viloxazine; D014364:Tryptophan