[A pharmacokinetic study of intra-arterial chemotherapy for prophylactic treatment of liver metastasis after hepatectomy for liver cancer].
As a fundamental study of efficacy of intra-arterial administration using ADM, ERB and MMC for prophylactic treatment of liver metastasis after hepatectomy for liver cancer, the pharmacokinetics of three drugs (ADM 10mg (n = 5), ERB 20mg (n = 3) and MMC 6 mg (n = 3)) were studied in patients who underwent hepatectomy after intra-arterial injection. The hepatic extraction calculated from the areas under the plasma concentration time curve of both administrations was 40% in ADM, 60% in ERB, and 0% in MMC. From these findings, it is suggested that intra-arterial administration could reduce by half the systemic toxic side effects of ADM or ERB, but the advantage of intraarterial infusion of MMC was not obvious.
Umekita
N
N
Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.
Awane
Y
Y
Maeshiro
T
T
Miyamoto
S
S
Yamada
F
F
Matsumine
T
T
D017024:Chemotherapy, Adjuvant; D004317:Doxorubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015251:Epirubicin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000517:prevention & control* / Q000601:surgery; D016685:Mitomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011182:Postoperative Care
D015251:Epirubicin; D016685:Mitomycin; D004317:Doxorubicin