Choleretic effect of andrographolide in rats and guinea pigs.
Andrographolide from the herb Andrographis paniculata (whole plant) per se produces a significant dose (1.5-12 mg/kg) dependent choleretic effect (4.8-73%) as evidenced by increase in bile flow, bile salt, and bile acids in conscious rats and anaesthetized guinea pigs. The paracetamol induced decrease in volume and contents of bile was prevented significantly by andrographolide pretreatment. It was found to be more potent than silymarin, a clinically used hepatoprotective agent.
Shukla
B
B
ICMR Centre for Advanced Pharmacological Research on Traditional Remedies, Central Drug Research Institute, Lucknow, India.
Visen
P K
PK
Patnaik
G K
GK
Dhawan
B N
BN
D000818:Animals; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D004224:Diterpenes; D005260:Female; D006168:Guinea Pigs; D008297:Male; D009284:Naphthols / Q000494:pharmacology*; D051381:Rats
D002756:Cholagogues and Choleretics; D004224:Diterpenes; D009284:Naphthols; C030419:andrographolide