The effects of peripherally administered chloroquine on body temperature.
The effects of chloroquine diphosphate on body temperature have been investigated in chicks. Chloroquine reduced both central and peripheral temperatures. The hypothermic action of chloroquine depended on the dose administered. The hypothermic action of chloroquine was maximal in chicks less than 6 days post-hatching; this effect decreased with increasing age. It is suggested that the hypothermic effect of chloroquine might contribute to its antipyretic activity in malaria fever.
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Department of Physiology and Pharmacology, Queen's Medical Center, Nottingham, England.
D000367:Age Factors; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002645:Chickens; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D007035:Hypothermia / Q000139:chemically induced; D007928:Lethal Dose 50; D008297:Male
D002738:Chloroquine