Fine needle aspiration of peripheral neuroepithelioma of soft tissues.
Peripheral neuroepithelioma of soft tissue is a malignant primitive neuroectodermal tumor that appears both in children and adults and usually has a poor outcome. Fine needle aspiration on two patients with tumors in the lower limbs showed small round cells with unipolar processes and a tendency to form Homer-Wright rosettes. The cells had a round to oval nucleus with fine chromatin, up to four small, conspicuous nucleoli and vacuolated, periodic acid-Schiff-positive cytoplasm. The diagnosis was supported by electron microscopic study of the aspirate, which showed features of neuroblastic differentiation (i.e., neurosecretory granules), and by histologic, immunohistochemical and cytogenetic study of the resected tumors.
González-Cámpora
R
R
Department of Pathology, University of Seville, Spain.
Otal-Salaverri
C
C
Panea Flores
P
P
Hevia-Vázquez
A
A
Gómez Pascual
A
A
San Martín Díez
V
V
D000293:Adolescent; D000328:Adult; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000473:pathology* / Q000648:ultrastructure*; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000648:ultrastructure*