title: Comparison of different metronidazole therapeutic regimens for bacterial vaginosis. A meta-analysis.
abstract: OBJECTIVE
  To evaluate the treatment of bacterial vaginosis with metronidazole to determine if there is a therapeutic regimen that is superior to all others with regard to cure and recurrence rates.
  
  
  METHODS
  Computer-assisted literature search, Medical Subject Index review, and references cited in articles identified.
  
  
  METHODS
  Clinical trials comparing different oral metronidazole regimens in which diagnostic criteria for bacterial vaginosis and criteria to detect cure to treatment were described.
  
  
  METHODS
  Articles that met inclusion criteria were critically appraised and those that passed were included in the analysis. Of 52 initial articles, 10 met criteria for inclusion and passed critical appraisal.
  
  
  RESULTS
  Patients were divided in groups according to the duration of therapy received: group A (n = 413), 2-g single dose; group B (n = 193), 2-g single daily dose for 2 days; group C (n = 317), 5 days; and group D (n = 280), 7 days. Cure rates on initial evaluation for the groups were 85%, 87%, 86%, and 87%, respectively. chi 2 Contingency table analysis showed no significant difference in cure rates among the groups (P = .78). Only 465 of these patients were evaluated for recurrence of disease. There was no significant difference in cure rates after 4 weeks of therapy (P = .4).
  
  
  CONCLUSIONS
  A 2-g single-dose metronidazole regimen is as effective as a single daily dose given for 2 days or a 5-day course or a 7-day course.
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center, Houston.
authors.forename: V I
authors.initials: VI
authors.lastname: Lugo-Miro
authors.forename: M
authors.initials: M
authors.lastname: Green
authors.forename: L
authors.initials: L
authors.lastname: Mazur
mesh_terms: D005260:Female; D006801:Humans; D015201:Meta-Analysis as Topic; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
chemical_list: D008795:Metronidazole