[Recurrence and survival rate of advanced gastric cancer after preoperative cisplatin intra-arterial injection therapy].
In our department, curative operations were performed for 49 patients with resectable advanced gastric cancer from Jan. 1988 to Feb. 1990. Among these patients, preoperative intra-arterial therapy using cisplatin (40 or 60 mg) was done for 17 patients. In this report, recurrence and survival rate of these patients were investigated. Survival rate of patients with preoperative intra-arterial injection therapy 42 months after operation was 56.15%, while that of patients without preoperative intra-arterial injection therapy was 56.62%. There were no significant differences between these two groups. And two peritoneal disseminations and one brain metastasis were seen in patients with preoperative intra-arterial injection therapy (recurrence rate, 17.6%), but no liver metastasis and local recurrence were noted. Seven recurrences were observed in patients without pre-operative intra-arterial CDDP injection therapy (local 3, liver 3, peritoneal dissemination 1, recurrence rate, 21.2%). We have already reported that much platinum accumulated in gastric cancer tissue and regional lymph nodes. This high accumulation of cisplatin can be the reason why no local recurrence was seen in patients with preoperative intra-arterial injection therapy. In conclusion, preoperative intra-arterial injection therapy using cisplatin may be an effective method to prevent postoperative local recurrence of resectable advanced gastric cancer.
Takeuchi
K
K
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Taniguchi
H
H
Miyata
K
K
Ueshima
Y
Y
Okano
S
S
Oguro
A
A
Sawai
K
K
Takahashi
T
T
D001932:Brain Neoplasms / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D010534:Peritoneal Neoplasms / Q000556:secondary; D011300:Preoperative Care; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
D002945:Cisplatin