[Mechanisms of hypoalgesia induced by intracisternal administration of PGD2 or PGE2].
Intracisternal administration of PGD2 (5 micrograms) and PGE2 (5 micrograms) induced hypoalgesia in conscious mice in acetic acid writhing test. The hypoalgesia caused by PGD2 was blocked by para-chlorophenylalanine, cyproheptadine or phenoxybenzamine. However, the suppression of writhing responses caused by PGE2 was not blocked at all by these drugs. These results indicate that the actions of PGD2 depend upon serotonin and norepinephrine systems.
Horiguchi
S
S
Department of Anesthesiology, Osaka Medical College, Takatsuki.
Minami
T
T
Hyodo
M
M
D000818:Animals; D002946:Cisterna Magna; D015232:Dinoprostone / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010146:Pain / Q000517:prevention & control*; D015230:Prostaglandin D2 / Q000008:administration & dosage / Q000494:pharmacology*
D015232:Dinoprostone; D015230:Prostaglandin D2