title: Eradication of Ureaplasma urealyticum from the amniotic fluid with transplacental antibiotic treatment.
abstract: Ureaplasma urealyticum was isolated from the amniotic fluid of a patient with preterm premature rupture of membranes at 24 weeks. A second amniocentesis performed 48 hours later indicated an increase in the number of neutrophils in the amniotic fluid. Treatment with erythromycin, ampicillin, gentamicin, and clindamycin was instituted for a period of 6 days. Amniotic fluid analysis from a third amniocentesis performed 24 hours after discontinuation of antibiotic treatment revealed only a few white blood cells and was negative for microorganisms. The pregnancy continued for 22 days after admission, at which time spontaneous labor began. The neonate survived with no sequelae and had negative blood cultures. Antibiotic treatment was associated with eradication of Ureaplasma urealyticum from the amniotic cavity, pregnancy prolongation, and neonatal survival.
authors.affiliation: Department of Obstetrics and Gynecology, Yale University School of Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Romero
authors.forename: Z
authors.initials: Z
authors.lastname: Hagay
authors.forename: J
authors.initials: J
authors.lastname: Nores
authors.forename: W
authors.initials: W
authors.lastname: Sepulveda
authors.forename: M
authors.initials: M
authors.lastname: Mazor
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000382:microbiology*; D000667:Ampicillin / Q000008:administration & dosage / Q000627:therapeutic use; D002821:Chorioamnionitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D011247:Pregnancy; D016869:Ureaplasma Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D016990:Ureaplasma urealyticum / Q000187:drug effects
chemical_list: D005839:Gentamicins; D002981:Clindamycin; D004917:Erythromycin; D000667:Ampicillin