Reduction of urinary oxalate by combined calcium and citrate administration without increase in urinary calcium oxalate stone formers.
Oxalic acid seems to play a far greater role in the formation of calcium oxalate stone than calcium. Three grams of calcium lactate and 3 g of sodium potassium citrate were administered to 46 urolithiasis patients, whose stones were mainly composed of calcium oxalate. Urinary oxalate level was reduced significantly without raising urinary calcium level by the administration of the two drugs for two weeks. The reduction of urinary oxalic acid was particularly remarkable in patients without hypercalciuria. The mechanism of action of these drugs was discussed.
Ito
H
H
Department of Urology, Teikyo University School of Medicine, Ichihara Hospital, Japan.
Suzuki
F
F
Yamaguchi
K
K
Nishikawa
Y
Y
Kotake
T
T
D000328:Adult; D000368:Aged; D002118:Calcium / Q000737:chemistry / Q000627:therapeutic use* / Q000652:urine; D002136:Calcium, Dietary / Q000008:administration & dosage; D002951:Citrates / Q000627:therapeutic use*; D019343:Citric Acid; D003404:Creatinine / Q000652:urine; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000517:prevention & control / Q000652:urine*; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000737:chemistry / Q000652:urine*; D019815:Oxalic Acid; D010758:Phosphorus / Q000652:urine
D002136:Calcium, Dietary; D002951:Citrates; D004338:Drug Combinations; D010070:Oxalates; D010758:Phosphorus; D019343:Citric Acid; D019815:Oxalic Acid; D003404:Creatinine; D008274:Magnesium; D002118:Calcium