Relationship between primary structure and activity in exorphins and endogenous opioid peptides.
We have found a correlation between the certain characteristics of primary structure and biologic activity in exorphins and endogenous opioid peptide family. The characteristics of primary structure are the content of certain segment pairs as well as the density of their arrangement in a peptide. These segment pairs represent basic elements of the regulatory peptide primary structure pattern, which was found recently [Dokl. Akad. Nauk USSR 289 (1986) 721-724; Int. J. Peptide Prot. Res. 38 (1991) 505-510].
Bakalkin Gya
Department of Drug Dependence Research, Karolinska Institute, Stockholm, Sweden.
Demuth
H U
HU
Nyberg
F
F
D000595:Amino Acid Sequence; D000818:Animals; D004723:Endorphins / Q000737:chemistry* / Q000502:physiology; D006168:Guinea Pigs; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000502:physiology; D051381:Rats; D013329:Structure-Activity Relationship
D004723:Endorphins; D010455:Peptides; C019178:exorphins