Comparative tissue tolerance of a new endodontic sealer.
An experimental radiopaque resin root canal sealer was tested for tissue biocompatibility in rat connective tissue. The controls were four widely used sealers: Sealapex, Kerr's sealer, AH-26, and Roth's sealer. Polyethylene tubes were filled with the sealers and allowed to set for 24 hours in 100% humidity. Each sealer was implanted in the connective tissue of Sprague-Dawley rats and removed after 3, 10, 20, 30, and 60 days, fixed, and histologically prepared for light microscope evaluation. At each time period there was practically no difference in the reaction of all the sealers. By 60 days, the total picture was one of well-tolerated biocompatibility.
Molloy
D
D
Tufts University School of Dental Medicine, Boston, Mass.
Goldman
M
M
White
R R
RR
Kabani
S
S
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001729:Bismuth / Q000737:chemistry; D017438:Bisphenol A-Glycidyl Methacrylate; D002126:Calcium Hydroxide / Q000737:chemistry; D003238:Connective Tissue / Q000473:pathology; D003287:Contrast Media; D001840:Dental Bonding; D003738:Dental Cements / Q000737:chemistry; D004338:Drug Combinations; D004853:Epoxy Resins; D015726:Giant Cells / Q000473:pathology; D006097:Granulation Tissue / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008422:Materials Testing; D008709:Methenamine / Q000737:chemistry; D009504:Neutrophils / Q000473:pathology; D011109:Polymethacrylic Acids / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D012117:Resins, Synthetic / Q000737:chemistry; D012387:Root Canal Filling Materials / Q000737:chemistry*; D012459:Salicylates; D012834:Silver / Q000737:chemistry; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014025:Titanium / Q000737:chemistry
D001672:Biocompatible Materials; D003287:Contrast Media; D003738:Dental Cements; D004338:Drug Combinations; D004853:Epoxy Resins; D011109:Polymethacrylic Acids; D012117:Resins, Synthetic; D012387:Root Canal Filling Materials; D012459:Salicylates; C055601:Sealapex; D012834:Silver; D017438:Bisphenol A-Glycidyl Methacrylate; C028044:epoxy resin AH-26; D014025:Titanium; D008709:Methenamine; D002126:Calcium Hydroxide; D001729:Bismuth