[Effect of phosphatidylcholine cholesterol liposomes on the growth of bacterial cultures].
The in vitro studies showed that incubation of S. aureus, P. aeruginosa, E. coli and P. mirabilis in the presence of phosphatidyl choline cholesterol liposomal suspension was accompanied by inhibited microbial growth. The effect was time- and dose-dependent. The arranged structure of the liposomal membranes played an important role in genesis of the bactericidal action of the liposomes since the use of lipids of the same composition in a nonpolysomal form markedly lowered the bactericidal effect.
Mel'iantseva
L P
LP
Kreĭnes
V M
VM
Mel'nikova
V M
VM
Gladshteĭn
A I
AI
D002308:Cardiolipins; D002784:Cholesterol / Q000031:analogs & derivatives*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D008081:Liposomes / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D002308:Cardiolipins; D008081:Liposomes; D010713:Phosphatidylcholines; C054448:VDRL antigen; D002784:Cholesterol
Vliianie fosfatidilkholinkholesterinovykh liposom na rost nekotorykh bakterial'nykh kul'tur.