In search of a correlation between the electron affinity and the radiosensitizing activity of some glyoxylic compounds.
The electron affinity of some glyoxylic compounds with radiosensitizing properties was evaluated using different approaches. The half-wave reduction potentials were measured by polarography, and the molecular structures in solution were determined by NMR spectroscopy. The electron affinity of the unhydrated and hydrated molecules was theoretically evaluated by means of a semi-empirical quantum mechanical procedure, the MNDO. The possible correlations between these values and the radiosensitizing efficiency of these glyoxylic compounds is discussed.
Cornago
P
P
Universidad Nacional de Educación a Distancia U.N.E.D., Madrid, Spain.
Santos
L
L
Smeyers
Y
Y
Lopez Zumel
C
C
Izquierdo
C
C
D004563:Electrochemistry; D004583:Electrons; D006037:Glyoxal / Q000737:chemistry*; D006038:Glyoxylates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008333:Mandelic Acids; D010084:Oxidation-Reduction; D010658:Phenylglyoxal / Q000737:chemistry; D011789:Quantum Theory; D011838:Radiation-Sensitizing Agents / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds
D006038:Glyoxylates; D008333:Mandelic Acids; D011838:Radiation-Sensitizing Agents; D013438:Sulfhydryl Compounds; C012482:phenylglyoxylic acid; D006037:Glyoxal; D010658:Phenylglyoxal