[The use of plasma from donor convalescent patients in the combined treatment of peritonitis].
The article analyses the treatment of 12 patients with diffuse purulent peritonitis in whom the titers of specific antibodies against microflora causing peritonitis were corrected in the period of secondary immunodeficiency. The authors suggest a new method for the treatment of peritonitis which is based on inclusion of convalescents' plasma after peritonitis in the therapeutic complex. This plasma contains specific antibodies against the cultured microflora in high titers and is a polyvalent hyperimmune medium which makes it possible to cause an effect on the level of humoral immunity. This improved the results of treatment: the titres of specific antibodies against the cultured microflora grew, such complications of diffuse peritonitis as the formation of circumscribed abscesses in the abdominal cavity and suppuration of the postoperative wound were encountered less frequently, mortality reduced by 16.6% as compared to the control group. The efficacy of the suggested methods was also proved in experiments on 164 animals.
Mil'kov
B O
BO
Patratiĭ
V K
VK
Sidorchuk
I I
II
Gres'ko
M M
MM
Polianskiĭ
I Iu
IIu
Belookiĭ
V V
VV
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000187:drug effects; D000917:Antibody Formation / Q000187:drug effects; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000276:immunology; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification*; D016219:Immunotherapy, Adoptive; D007709:Klebsiella / Q000276:immunology; D010538:Peritonitis / Q000276:immunology / Q000628:therapy*; D011182:Postoperative Care; D011549:Pseudomonas / Q000276:immunology; D051381:Rats; D013210:Staphylococcus / Q000276:immunology
D000907:Antibodies, Bacterial; D007106:Immune Sera
Primenenie plazmy donorov-rekonvalestsentov v kompleksnom lechenii peritonita.