title: Toxicity of a new dosage format, cisplatin incorporated in lactic acid oligomer microspheres, in mice.
abstract: A new drug delivery system, cisplatin incorporated into lactic acid oligomer microspheres (CDDP-MS), was developed for the treatment of peritoneal carcinomatoses. We studied the acute toxicity and pathological effects of CDDP-MS injected intraperitoneally in mice. The 50% lethal dose was 23.8 mg/kg (21.3-26.7 mg/kg at 95% level of confidence), which was 1.76 times that of the cisplatin aqueous solution of 13.5 mg/kg (11.9-15.3 mg/kg at 95% level of confidence). The duration for the restoration of the body weight loss was prolonged when CDDP-MS at doses close to the 50% lethal dose was administered, as compared with the cisplatin aqueous solution at doses close to its 50% lethal dose. On autopsy there were no macroscopic or microscopic differences between the two dosage forms.
authors.affiliation: First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Sasabe
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: S
authors.initials: S
authors.lastname: Shobayashi
authors.forename: S
authors.initials: S
authors.lastname: Muranishi
authors.forename: S
authors.initials: S
authors.lastname: Tashima
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D002945:Cisplatin / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D008815:Mice, Inbred Strains; D008863:Microspheres; D009929:Organ Size / Q000187:drug effects; D011091:Polyesters / Q000737:chemistry
chemical_list: D011091:Polyesters; C033616:poly(lactide); D002945:Cisplatin