title: Resection of dominant opercular gliosis in refractory partial epilepsy. Report of two cases.
abstract: Frontal opercular gliosis in the dominant hemisphere caused medically refractory partial epilepsy in two patients. Both patients were aphasic during their seizures, but otherwise had normal speech. Magnetic resonance images showed well-demarcated lesions resembling tumors in each patient; on heavily T2-weighted images, the lesions were hyperintense compared with normal brain. Cortical mapping with subdural grids localized speech to the area of the lesions; therefore, the resections were performed under local anesthesia and speech was tested throughout the procedure. Postoperatively, both patients were seizure-free and had no new neurological deficits. Well-demarcated lesions, even in the dominant operculum, can be safely removed in patients with medically refractory partial epilepsy.
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
authors.forename: W G
authors.initials: WG
authors.lastname: Obana
authors.forename: K D
authors.initials: KD
authors.lastname: Laxer
authors.forename: P H
authors.initials: PH
authors.lastname: Cogen
authors.forename: J A
authors.initials: JA
authors.lastname: Walker
authors.forename: R L
authors.initials: RL
authors.lastname: Davis
authors.forename: N M
authors.initials: NM
authors.lastname: Barbaro
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D001931:Brain Mapping; D002648:Child; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000209:etiology*; D005260:Female; D005911:Gliosis / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D016896:Treatment Outcome