title: Evaluation of a QRS scoring system for estimating myocardial infarct size. VIII. Specificity in a control group with left ventricular hypertrophy and proposal of a new scoring system for use with this confounding factor.
abstract: Electrocardiographic differentiation between left ventricular hypertrophy (LVH) and myocardial infarction (MI) is often difficult because both diagnoses are based primarily on QRS changes on the electrocardiogram (ECG). The specific goal of this study was the development of ECG criteria that could be used with the complete Selvester QRS scoring system for MI size in patients with LVH. A study population of 127 patients had significant aortic valve disease verified by cardiac catheterization. Inclusion in the study required no significant coronary artery disease, no focal contraction abnormality on the left ventriculogram, and no documented MI. Quantitative criteria for LVH developed by Bonner (IBM) and also those developed by the Cornell group were used to determine the ECG evidence for LVH in each patient. One or both sets of criteria were met in 110 (87%) of the 127 patients. This group was compared to a previously evaluated control population of 500 normal subjects. The complete 54-criteria, 32-point QRS MI size scoring system was applied to the 12-lead ECG of both groups. The score was 98% specific in the normal controls and 73% specific in the LVH group using a score of greater than 3 points as diagnostic for MI. Of the 54 individual QRS criteria, 16 failed to achieve 95% specificity in the LVH population: 13 were for anterior (and apical), 2 for inferior, and 1 for posterior locations. Of these 16, minor modifications to 11 were sufficient to achieve the 95% specificity standard.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, North Carolina.
authors.forename: C J
authors.initials: CJ
authors.lastname: Freye
authors.forename: N B
authors.initials: NB
authors.lastname: Wagner
authors.forename: C M
authors.initials: CM
authors.lastname: Howe
authors.forename: N C
authors.initials: NC
authors.lastname: Stack
authors.forename: R E
authors.initials: RE
authors.lastname: Ideker
authors.forename: R H
authors.initials: RH
authors.lastname: Selvester
authors.forename: G S
authors.initials: GS
authors.lastname: Wagner
mesh_terms: D006332:Cardiomegaly / Q000175:diagnosis* / Q000453:epidemiology; D015986:Confounding Factors, Epidemiologic; D003937:Diagnosis, Differential; D004562:Electrocardiography / Q000379:methods*; D005069:Evaluation Studies as Topic; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000453:epidemiology; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted