Relationship between parameters of serotonin transport and antidepressant plasma levels or therapeutic response in depressive patients treated with paroxetine and amitriptyline.
In a double-blind clinical study, antidepressant plasma levels, parameters of platelet serotonin (5-HT) transport (Km, Vmax and basal platelet 5-HT content) and therapeutic response were measured in depressive patients treated with either paroxetine (30 mg/day) or amitriptyline (150 mg/day) for 6 weeks. No correlation could be found between paroxetine plasma levels and therapeutic outcome after 2, 4 and 6 weeks of treatment. In contrast to the amitriptyline group, a marked increase in Km from baseline to week 2 was determined in paroxetine-treated patients, with Km increase being correlated with paroxetine plasma levels at week 2. However, no significant relationship could be found between 5-HT transport parameters and any of the outcome measures in either treatment group.
Kuhs
H
H
Department of Psychiatry, University of Münster, Germany.
Schlake
H P
HP
Rolf
L H
LH
Rudolf
G A
GA
D000328:Adult; D000639:Amitriptyline / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009661:Nortriptyline / Q000493:pharmacokinetics; D017374:Paroxetine; D010880:Piperidines / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000097:blood*; D012702:Serotonin Antagonists / Q000493:pharmacokinetics / Q000627:therapeutic use*
D000928:Antidepressive Agents; D010880:Piperidines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D000639:Amitriptyline; D012701:Serotonin; D017374:Paroxetine; D009661:Nortriptyline