title: Carcinogenicity study of gamma-oryzanol in F344 rats.
abstract: The carcinogenic potential of gamma-oryzanol, a drug mainly used for the treatment of hyperlipidaemia, was studied in F344 rats. Groups of 50 males and 50 females were fed a diet containing 0 (control), 200, 600 or 2000 mg gamma-oryzanol/kg body weight/day for 2 yr. Although females in the highest dose group (2000 mg/kg body weight) showed a slight decrease in body weight at 104 wk, there were no treatment-related changes in general condition, food consumption, mortality, organ weight or haematology. Histopathological examination showed various tumours in all groups, including the control group. In the control and 2000-mg/kg groups, high tumour incidences were observed in the testes, pituitary and thyroid of males, and in the pituitary, uterus and mammary gland of females; however, there was no significant increase in the incidence of any tumours between the control and the 2000-mg/kg groups. The findings indicate that under the experimental conditions described gamma-oryzanol was not carcinogenic in F344 rats.
authors.affiliation: Department of Toxicology, Otsuka Pharmaceutical Co. Ltd, Tokushima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tamagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Otaka
authors.forename: S
authors.initials: S
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Kadowaki
authors.forename: F
authors.initials: F
authors.lastname: Uda
authors.forename: T
authors.initials: T
authors.lastname: Miwa
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009929:Organ Size / Q000187:drug effects; D010666:Phenylpropionates / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002273:Carcinogens; D000960:Hypolipidemic Agents; D010666:Phenylpropionates; C013172:gamma-oryzanol