title: Stress-induced modulation of the immune response to recombinant hepatitis B vaccine.
abstract: Each of a series of three hepatitis B (Hep B) inoculations was given to 48 second-year medical students on the 3rd day of a 3-day examination series to study the effect of academic stress on the ability to generate an immune response to a primary antigen. Those students who seroconverted after the first injection (25%) were significantly less stressed and anxious than those who did not seroconvert at that time. In addition, students who reported greater social support demonstrated a stronger immune response to the vaccine at the time of the third inoculation, as measured by antibody titers to Hep B surface antigen (HBsAg) and the blastogenic response to a HBsAg peptide (SAg).
authors.affiliation: Department of Medical Microbiology and Immunology, Ohio State University College of Medicine, Columbus 43210.
authors.forename: R
authors.initials: R
authors.lastname: Glaser
authors.forename: J K
authors.initials: JK
authors.lastname: Kiecolt-Glaser
authors.forename: R H
authors.initials: RH
authors.lastname: Bonneau
authors.forename: W
authors.initials: W
authors.lastname: Malarkey
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
authors.forename: J
authors.initials: J
authors.lastname: Hughes
mesh_terms: D000328:Adult; D000917:Antibody Formation; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control; D006511:Hepatitis B Antigens / Q000097:blood / Q000276:immunology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010555:Personality Inventory; D012944:Social Support; D013315:Stress, Psychological / Q000276:immunology*; D013337:Students, Medical; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000276:immunology*
chemical_list: D006511:Hepatitis B Antigens; D014761:Viral Hepatitis Vaccines