title: Outpatient management of chronic suppurative otitis media without cholesteatoma in children.
abstract: Prolonged antipseudomonal parenteral antibiotic therapy combined with daily aural toilet has been effective in resolving long standing ear discharge in children with chronic suppurative otitis media. However, such treatment suffered from the disadvantages of prolonged hospitalization. We conducted a prospective study to investigate the feasibility and efficacy of exclusive outpatient treatment of children with chronic suppurative otitis media without cholesteatoma who had failed ototopical/oral antimicrobial therapy. The treatment consisted of daily aural toilet (suction and debridement) and twice daily parenteral ceftazidime (50 mg/kg/dose). Thirty-seven children were included. The duration of discharge from the ear before treatment was 6 to 121 months (median, 30 months). Aerobic cultures yielded Pseudomonas aeruginosa in 97%, often with other organisms. The management and follow-up were performed jointly by otolaryngology and infectious diseases physicians using the hospital ambulatory services. The route of ceftazidime administration (intravenous or intramuscular) was chosen according to the parents' and patients' convenience. Discharge stopped within 3 to 20 days (median, 8 days) in all children but one. Seventy-six percent of the 29 children available for follow-up 12 months after treatment were still free of discharge. Our results demonstrate that a regiment combining daily aural toilet and twice daily parenteral ceftazidime is highly efficacious in resolving ear discharge in children with chronic suppurative otitis media without cholesteatoma and that such a regimen does not require hospitalization.
authors.affiliation: Pediatric Infectious Disease Unit, Ben-Gurion University Negev, Beer-Sheva, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Dagan
authors.forename: D M
authors.initials: DM
authors.lastname: Fliss
authors.forename: M
authors.initials: M
authors.lastname: Einhorn
authors.forename: M
authors.initials: M
authors.lastname: Kraus
authors.forename: A
authors.initials: A
authors.lastname: Leiberman
mesh_terms: D000293:Adolescent; D000553:Ambulatory Care; D002442:Ceftazidime / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002781:Cholesteatoma; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010035:Otitis Media, Suppurative / Q000188:drug therapy / Q000628:therapy*; D011446:Prospective Studies; D013396:Suction
chemical_list: D002442:Ceftazidime