title: Topography of glycosylation reactions in the endoplasmic reticulum.
abstract: A variety of distinct protein glycosylation reactions occur in the endoplasmic reticulum (ER) of eukaryotic cells. In some instances, both the proteins to be glycosylated and the precursor sugar donors must be translocated across the membrane from the cytoplasm to the lumen of the ER. Elucidation of the individual steps in each of the glycosylation pathways has revealed the topographic complexity of these reactions.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Massachusetts Medical Center, Worcester 01655.
authors.forename: C
authors.initials: C
authors.lastname: Abeijon
authors.forename: C B
authors.initials: CB
authors.lastname: Hirschberg
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D002240:Carbohydrate Sequence; D002462:Cell Membrane / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000737:chemistry / Q000378:metabolism*; D006017:Glycolipids / Q000378:metabolism; D006031:Glycosylation; D017261:Glycosylphosphatidylinositols; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D010716:Phosphatidylinositols / Q000378:metabolism; D011103:Polyisoprenyl Phosphate Monosaccharides / Q000378:metabolism
chemical_list: D006017:Glycolipids; D017261:Glycosylphosphatidylinositols; D010716:Phosphatidylinositols; D011103:Polyisoprenyl Phosphate Monosaccharides; C018439:N-acetylglucosaminylpyrophosphoryldolichol; D000117:Acetylglucosamine