[The physiopathology of acute pancreatitis: the role of platelet-activating factor (PAF)].
PAF-acether (platelet-activating factor) is a vasoactive substance appearing in plasma under certain pathological circumstances. The aim of our study was to determine plasma, peritoneal exudate and tissular levels of PAF-acether in bile reflux acute necro-hemorrhagic pancreatitis (ANP) in the conscious rat 60 minutes after induction. As we have previously demonstrated, ANP causes overwhelming shock in conscious rats. PAF-acether levels increased in plasma and peritoneal exudate of rats with ANP. In contrast, tissular PAF levels were similar to basal values. In conclusion, these data suggest a role of PAF-acether in the hemodynamic impairment that follows induction of pancreatitis.
Ais
J G
JG
Servicio de Cirugía de Aparato Digestivo, Fundación Jiménez Díaz, Universidad Autónoma de Madrid.
Novo
C
C
Gómez-Garre
M
M
López-Farre
A
A
López-Novoa
J M
JM
Romeo
J M
JM
D000208:Acute Disease; D000818:Animals; D001202:Ascitic Fluid / Q000737:chemistry; D001681:Biological Assay; D004195:Disease Models, Animal; D008297:Male; D010179:Pancreas / Q000737:chemistry; D010195:Pancreatitis / Q000503:physiopathology*; D010972:Platelet Activating Factor / Q000032:analysis / Q000302:isolation & purification / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D010972:Platelet Activating Factor
Fisiopatología de la pancreatitis aguda: el papel del factor activador plaquetario (PAF).