title: Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet.
abstract: Tubeimoside 1, one of the new triterpenoid saponins from the bulb of Bolbostemma paniculatum (Maxim) Franquet, had an anti-inflammatory effect on mouse ear edema induced by arachidonic acid and 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, a potent anti-tumorigenic effect of tubeimoside 1 was observed in 2-stage carcinogenesis of mouse skin after oral administration as well as topical application. Thus, tubeimoside 1 appears to be a promising agent for cancer chemoprevention.
authors.affiliation: Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian, People's Republic of China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Yu
authors.forename: R D
authors.initials: RD
authors.lastname: Ma
authors.forename: Y Q
authors.initials: YQ
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: J
authors.initials: J
authors.lastname: Takayasu
authors.forename: W Z
authors.initials: WZ
authors.lastname: He
authors.forename: M
authors.initials: M
authors.lastname: Chang
authors.forename: J
authors.initials: J
authors.lastname: Zhen
authors.forename: W S
authors.initials: WS
authors.lastname: Liu
authors.forename: S X
authors.initials: SX
authors.lastname: Fan
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D005260:Female; D051379:Mice; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014315:Triterpenes
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C051084:tubeimoside I; D013755:Tetradecanoylphorbol Acetate