title: Altered aspartate in Alzheimer neurofibrillary tangles.
abstract: Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo post-translational modification by racemization to D-aspartate, or by isomerization to the L-isoaspartyl form in which the peptide chain links through the beta carboxyl group of the residue. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a significantly greater number of these modified aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.
authors.affiliation: Department of Chemistry, University of Miami, Coral Gables, Florida 33124.
authors.forename: I L
authors.initials: IL
authors.lastname: Payan
authors.forename: S J
authors.initials: SJ
authors.lastname: Chou
authors.forename: G H
authors.initials: GH
authors.lastname: Fisher
authors.forename: E H
authors.initials: EH
authors.lastname: Man
authors.forename: C
authors.initials: C
authors.lastname: Emory
authors.forename: W H
authors.initials: WH
authors.lastname: Frey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001224:Aspartic Acid / Q000737:chemistry / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008745:Methylation; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase; D011496:Protein Methyltransferases / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D001224:Aspartic Acid; D011496:Protein Methyltransferases; D026601:Protein D-Aspartate-L-Isoaspartate Methyltransferase