title: Effect of daytime protein restriction on nutrient intakes of free-living Parkinson's disease patients.
abstract: Studies have shown that severe daytime restriction of dietary protein improves the efficacy of L-dopa and reduces response fluctuations in some Parkinson's disease (PD) patients. This study investigated the nutritional adequacy of the daytime restricted-protein diet. Eleven free-living PD patients suffering from unpredictable response fluctuations to L-dopa were counseled to limit protein intake to approximately 10 g before 1700. Three sets of 6-d food records obtained during the 8-wk study showed that while on the test diet, mean intakes of most nutrients remained above the recommended nutrient intakes, although significant decreases occurred in protein, calcium, iron, phosphorus, riboflavin, and niacin intakes. The impact of the test diet on nutritional status as evaluated by changes in body weight and serum prealbumin was small. We conclude that healthy and highly motivated patients can maintain adequate intakes of most nutrients while restricting daytime protein intake. However, nutrient intakes might be compromised in patients whose regular diets are marginally adequate.
authors.affiliation: School of Family and Nutritional Sciences, University of British Columbia, Vancouver, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Paré
authors.forename: S I
authors.initials: SI
authors.lastname: Barr
authors.forename: S E
authors.initials: SE
authors.lastname: Ross
mesh_terms: D000368:Aged; D001835:Body Weight; D004044:Dietary Proteins / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology*; D011228:Prealbumin / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D011795:Surveys and Questionnaires
chemical_list: D004044:Dietary Proteins; D011228:Prealbumin; D012709:Serum Albumin; D007980:Levodopa