title: Low biological activity of Helicobacter pylori lipopolysaccharide.
abstract: Lipopolysaccharide from the gastroduodenal pathogen Helicobacter pylori was tested for its ability to induce mitogenicity in mouse spleen cells, pyrogenicity in rabbits, and toxic lethality in galactosamine-sensitized mice. Compared with those for enterobacterial lipopolysaccharide, mitogenicity and pyrogenicity were a thousand-fold lower and lethal toxicity was 500-fold lower. We suggest that the phosphorylation pattern and acylation in lipid A are responsible for the low biological activity.
authors.affiliation: Department of Bacteriology, National Public Health Institute, Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Muotiala
authors.forename: I M
authors.initials: IM
authors.lastname: Helander
authors.forename: L
authors.initials: L
authors.lastname: Pyhälä
authors.forename: T U
authors.initials: TU
authors.lastname: Kosunen
authors.forename: A P
authors.initials: AP
authors.lastname: Moran
mesh_terms: D000818:Animals; D004247:DNA / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016480:Helicobacter pylori / Q000472:pathogenicity*; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000502:physiology* / Q000633:toxicity; D051379:Mice
chemical_list: D008070:Lipopolysaccharides; D004247:DNA