Malignant peripheral nerve sheath tumor arising spontaneously from retroperitoneal ganglioneuroma: a case report, review of the literature, and immunohistochemical study.
We report a case of a malignant peripheral nerve sheath tumor arising from a retroperitoneal ganglioneuroma in an adult male. There was no known previous history of a childhood neuroblastoma or of radiation therapy. In addition, the patient had no stigmata or family history of von Recklinghausen's neurofibromatosis. This case provides evidence that, although rare, spontaneous malignant transformation of ganglioneuroma can occur. Immunohistochemical studies supported that the spindle cell component was of nerve sheath origin.
Ghali
V S
VS
Department of Pathology, Beth Israel Medical Center, Mount Sinai School of Medicine, City University of New York, New York 10003.
Gold
J E
JE
Vincent
R A
RA
Cosgrove
J M
JM
D000328:Adult; D002471:Cell Transformation, Neoplastic; D005729:Ganglioneuroma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D010524:Peripheral Nervous System Neoplasms / Q000473:pathology*; D012186:Retroperitoneal Neoplasms / Q000473:pathology*