title: Increase in glucose consumption by acetylcysteine during hyperglycemic clamp. A study with healthy volunteers.
abstract: Thiols have been shown to be related to insulin secretion and to uptake of glucose into tissues. In the present study the effects of i.v. administration of acetylcysteine (N-acetylcysteine, NAC, CAS 616-91-1) on glucose consumption and plasma free thiols were studied in young healthy volunteers during hyperglycemic clamp. NAC (0.5-2.0 mg/kg) significantly increased glucose consumption. This effect was not obvious at higher doses of NAC. Plasma free NAC depended on the dose of NAC injected. The t1/2 of NAC was 11 min. NAC produced significant increases of plasma cysteine concentrations, and a slight but insignificantly increase of plasma glutathione. These data suggest that a moderate increase in plasma thiols augments glucose consumption during hyperglycemic clamp.
authors.affiliation: Department of Pharmacology, University of Tübingen, Fed. Rep. of Germany.
authors.forename: H P
authors.initials: HP
authors.lastname: Ammon
authors.forename: P H
authors.initials: PH
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Eggstein
authors.forename: C
authors.initials: C
authors.lastname: Wintermantel
authors.forename: B
authors.initials: B
authors.lastname: Aigner
authors.forename: H
authors.initials: H
authors.lastname: Safayhi
authors.forename: M
authors.initials: M
authors.lastname: Stützle
authors.forename: W
authors.initials: W
authors.lastname: Renn
mesh_terms: D000111:Acetylcysteine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005978:Glutathione / Q000097:blood; D006207:Half-Life; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008954:Models, Biological
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005978:Glutathione; D005947:Glucose; D000111:Acetylcysteine