title: Low plasma levels of insulin-like growth factor I in Perthes' disease. A controlled study of 59 consecutive children.
abstract: We studied Insulin-like Growth Factor I (IGF I) plasma levels, standing height, and weight in 59 consecutive children with Perthes' disease and 59 matched controls. The plasma-IGF I levels, measured by radioimmunoassay after acid ethanol extraction, were reduced in affected children during the first 2 years after the diagnosis of Perthes' disease. Partially paralleling the alterations in IGF I plasma levels, there was a tendency towards growth arrest and impaired weight-gain during early-stage disease, followed by catch-up growth and increased weight-gain. No relation was found between degree of femoral head involvement, according to Catterall (1971), and IGF I plasma-levels or body mass. Our data may reflect an impaired synthesis or release of IGF I relative to age in Perthes' disease, or changes in the affinity or metabolism of IGF binding proteins. The observed changes seem to be of a temporary nature.
authors.affiliation: Köln University Department of Orthopedics, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Neidel
authors.forename: D
authors.initials: D
authors.lastname: Zander
authors.forename: M H
authors.initials: MH
authors.lastname: Hackenbroch
mesh_terms: D000293:Adolescent; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007873:Legg-Calve-Perthes Disease / Q000097:blood*; D008297:Male; D012044:Regression Analysis
chemical_list: D007334:Insulin-Like Growth Factor I