title: Indocyanine green clearance and hepatic function during and after prolonged anaesthesia: comparison of halothane with isoflurane.
abstract: Specific biochemical and physiological tests of liver function were used to assess 20 consecutive patients undergoing prolonged head and neck surgery with halothane or isoflurane anaesthesia. Hepatic function was assessed by measurement of serum concentrations of total bilirubin and albumin, and plasma activity of pseudocholinesterase, gamma-glutamyl transferase (GGT), aspartate transaminase (AST), alkaline phosphatase (ALP) and hepatic glutathione S-transferase. Plasma clearance of indocyanine green was used as an estimate of hepatic blood flow. No major differences were observed in serum concentrations of GGT, ALP, bilirubin, albumin or pseudocholinesterase. Serum AST activity in those patients receiving halothane was increased at 24 h and at 48 h compared with those who received isoflurane (not statistically significant). Glutathione S-transferase activity was increased significantly in the halothane group throughout the period of study, compared with those who received isoflurane. Similarly, there was a significant difference between the two groups as measured by plasma clearance of indocyanine green: in the halothane group there was a slower disappearance rate of the dye from plasma at specific times than in the patients who received isoflurane. Our data support the use of isoflurane rather than halothane for prolonged anaesthesia.
authors.affiliation: Department of Anaesthesia, Ulster Hospital, Dundonald, Belfast.
authors.forename: J M
authors.initials: JM
authors.lastname: Murray
authors.forename: B J
authors.initials: BJ
authors.lastname: Rowlands
authors.forename: T R
authors.initials: TR
authors.lastname: Trinick
mesh_terms: D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D005982:Glutathione Transferase / Q000097:blood; D006221:Halothane / Q000494:pharmacology; D006801:Humans; D007208:Indocyanine Green; D007530:Isoflurane / Q000494:pharmacology; D008099:Liver / Q000098:blood supply / Q000502:physiology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
chemical_list: D007530:Isoflurane; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D007208:Indocyanine Green; D006221:Halothane