Iron-tumor cell interaction and regulation of Ca2+ homeostasis: their implication in tumor growth.
Using [59Fe] ferric lactate, a direct relationship between iron concentration and [59Fe] uptake by Ehrlich ascites tumor cells was found. Deferoxamine and albumin inhibited this uptake. Electrophoresis showed that both molecules complexed iron from ferric lactate. [45Ca] uptake in the presence of ferric lactate showed the same inhibition, and an iron mass-dependence, these findings suggest an iron--cell membrane interaction as the cause of this phenomenon. The implication of iron--tumor cell membrane interaction in tumor growth regulation is discussed.
Anghileri
L J
LJ
Laboratory of Biophysics, Faculty of Medicine, University of Nancy, France.
Martinez
A C
AC
Maleki
P
P
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000493:pharmacokinetics; D002132:Calcium Radioisotopes; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division / Q000502:physiology; D003676:Deferoxamine / Q000494:pharmacology; D004586:Electrophoresis; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D007501:Iron / Q000378:metabolism / Q000493:pharmacokinetics*; D007504:Iron Radioisotopes; D007700:Kinetics; D007773:Lactates / Q000378:metabolism / Q000493:pharmacokinetics; D019344:Lactic Acid; D051379:Mice; D014407:Tumor Cells, Cultured / Q000187:drug effects
D002132:Calcium Radioisotopes; D007504:Iron Radioisotopes; D007773:Lactates; D019344:Lactic Acid; D007501:Iron; D003676:Deferoxamine; D002118:Calcium