Transplant renal artery stenosis in a canine model: evaluation of hemodynamic changes, renal function, and captopril renography.
The utility of captopril renography in the diagnosis of renal artery stenosis was examined in a canine model of renal autotransplantation with and without renal artery clipping. Autotransplantation of the left kidney to the right iliac fossa with contralateral nephrectomy was done in female mongrel dogs. One group served as controls (n = 6). A second group underwent constriction of the external diameter of the renal artery at the time of the operation to produce renal artery stenosis (n = 7). At two weeks postoperatively, glomerular filtration rate was significantly lower in the renal artery stenosis group (26.2 +/- 3.4 ml./min. vs. 38.2 +/- 3.2 ml./min., p less than 0.05), and deteriorated further after captopril administration (17.9 +/- 2.7 ml./min. vs. 26.2 +/- 3.4 ml./min., p less than 0.05). Despite the presence of hemodynamically significant renal artery stenosis, mean arterial pressure was not different between the two groups (134 +/- 4 mm. Hg vs. 132 +/- 6 mm. Hg, control vs. renal artery stenosis, p = NS). Captopril renography did not enable detection of renal artery stenosis in this autotransplant model.
Sankari
B R
BR
Department of Urology, Cleveland Clinic Foundation, Ohio 44195.
Stowe
N T
NT
Nally
J V
JV
Gavin
J P
JP
Remzi
F H
FH
Novick
A C
AC
D000818:Animals; D002216:Captopril; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate; D016030:Kidney Transplantation / Q000502:physiology; D011866:Radioisotope Renography; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012079:Renal Circulation; D012084:Renin-Angiotensin System
D002216:Captopril