Synthesis, radiochemistry and biological evaluation of technetium-99m complexes with 1,8-diamine-3,6-dithiaoctane (DDO) ligands.
The synthesis, radiochemical analysis and biological characteristics of some 1,8-diamine-3,6-dithiaoctane derivatives labelled with Tc-99m are reported. Analysis by HPLC shows that most of the 99mTc-chelates are multicomponent. Furthermore, almost all 99mTc-complexes isolated by HPLC are lipophilic and stable in vitro. The biodistributions of the most lipophilic of these complexes were evaluated in mice. The N-morpholinylethyl and N,N'-bisalicylyl derivatives of 1,8-diamine-3,6-dithiaoctane yielded 99mTc-complexes which exhibit considerable uptake and retention in organs of interest, such as the heart and the brain.
Maina
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National Centre for Scientific Research Demokritos, Athens, Greece.
Chiotellis
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D000818:Animals; D001921:Brain / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003959:Diamines / Q000737:chemistry* / Q000493:pharmacokinetics; D008024:Ligands; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D015609:Organotechnetium Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D003959:Diamines; D008024:Ligands; D015609:Organotechnetium Compounds; C076756:1,8-diamine-3,6-dithiaoctane