title: Long-term effects of linoleic-acid-enriched diet on albuminuria and lipid levels in type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion.
abstract: We conducted a 2-year prospective randomised study to investigate the effects of a linoleic-acid-enriched diet on albuminuria and lipid levels in Type 1 (insulin-dependent) diabetic patients with elevated urinary albumin excretion (overnight urinary albumin excretion rate between 10 and 200 micrograms/min). Thirty-eight patients were randomly assigned to increase dietary polyunsaturated:saturated fatty acids ratio to 1.0 by replacement of saturated fat with linoleic-acid-rich products (n = 18, two dropouts, analysis was performed in n = 16) or to continue their usual diet (n = 20). The total fat and protein content of the diet was unaltered. Clinical characteristics, albuminuria, blood pressure, glomerular filtration rate, metabolic control and dietary composition were similar in the two groups at baseline. In the high linoleic acid diet group, linoleic intake rose from 7 +/- 4 to 11 +/- 2 energy % and polyunsaturated:saturated fatty acids ratio rose from 0.60 +/- 0.28 to 0.96 +/- 0.16 (p less than 0.001 compared to usual diet group). The median increase albuminuria was 58% (95% confidence interval, 13 to 109) during the first year (p less than 0.02) and 55% (95% confidence interval, 11 to 127) (p less than 0.01) during the second year. Glomerular filtration rate remained unaltered and filtration fraction tended to rise (p less than 0.05 compared to usual diet group). In the usual diet group, albuminuria did not significantly increased by 16% (95% confidence interval, -17 to 38) and glomerular filtration rate declined during the second year. Blood pressure tended to rise similarly in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Endocrinology, University Hospital, Groningen, The Netherlands.
authors.forename: R P
authors.initials: RP
authors.lastname: Dullaart
authors.forename: B J
authors.initials: BJ
authors.lastname: Beusekamp
authors.forename: S
authors.initials: S
authors.lastname: Meijer
authors.forename: K
authors.initials: K
authors.lastname: Hoogenberg
authors.forename: J J
authors.initials: JJ
authors.lastname: van Doormaal
authors.forename: W J
authors.initials: WJ
authors.lastname: Sluiter
mesh_terms: D000328:Adult; D000419:Albuminuria; D001794:Blood Pressure; D001835:Body Weight; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000652:urine; D003927:Diet, Diabetic; D004041:Dietary Fats; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012044:Regression Analysis; D012079:Renal Circulation
chemical_list: D004041:Dietary Fats; D008041:Linoleic Acids; D008055:Lipids; D008074:Lipoproteins; D019787:Linoleic Acid