[Familial amyotrophic lateral sclerosis associated with Huntington chorea with increased aspartate level in the cerebrospinal fluid].
We report the case of a patient who presented with both amyotrophic lateral sclerosis and Huntington's disease. Interestingly, aspartate level was increased in the lumbar CSF. In vitro and in vivo studies have convincingly suggested that these two neurodegenerative diseases could be related to an excitotoxic mechanism.
Blin
O
O
Clinique des maladies du système nerveux et de l'appareil locomoteur, CNRS, Marseille.
Samuel
D
D
Guieu
R
R
Pouget
J
J
Nieoullon
A
A
Serratrice
G
G
D000596:Amino Acids / Q000134:cerebrospinal fluid; D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid / Q000150:complications / Q000235:genetics*; D001224:Aspartic Acid / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid / Q000150:complications*; D008875:Middle Aged
D000596:Amino Acids; D001224:Aspartic Acid
Sclérose latérale amyotrophique familiale associée à une chorée de Huntington avec élévation du taux d'aspartate dans le liquide céphalo-rachidien.