Therapeutic monitoring of antiepileptic drugs. II--Analytical techniques.
Recent development of analytical techniques for therapeutic drug monitoring of antiepileptic drugs are reviewed. The most commonly used procedures are high performance liquid chromatography (HPLC) and immunochemical techniques. Innovations in HPLC include commercialization of instrumentations for automatic extraction and injection of biological samples and development of restricted access media columns for direct injection of plasma without prior extraction. For immunochemical techniques, principles of "classical" major procedures are described together with the new immunoenzymatic and immunochromatographic methods in solid phase, specifically developed with the aim of making drug monitoring possible outside the traditional laboratory.
Albani
F
F
Laboratory of Neuropharmacology, Institute of Clinical Neurology, University of Bologna.
Riva
R
R
Baruzzi
A
A
D000927:Anticonvulsants / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D007120:Immunochemistry
D000927:Anticonvulsants