title: Pulp response to bases and cavity depths.
abstract: In cavities of ferret canines, preparation depth and bases were compared as to their effect on odontoblasts and to rate of dentin formation. These were measured by injecting 3H-proline at 0, 20 and 40 days post-preparation. Odontoblast activity was determined by label density in each band; inter-band distances indicated the amount of dentin formed. Correlations were by Pearson's coefficient. The following were determined: 1) cavity depth (remaining dentin thickness) was the major factor in odontoblast response and in dentin formation; deeper cavities suppressed odontoblasts with less subsequent dentin formation at all time periods; 2) basing materials had little effect on odontoblast activity or on the rate of dentin formation. An exception was in deep cavities, with Ca(OH)2 showing more label; this activity was temporary with no increased dentin formation; 3) there was no evidence of a "rebound" response.
authors.affiliation: University of Iowa, College of Dentistry.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: R E
authors.initials: RE
authors.lastname: Walton
authors.forename: J W
authors.initials: JW
authors.lastname: Osborne
mesh_terms: D000818:Animals; D002126:Calcium Hydroxide / Q000633:toxicity; D003736:Dental Cavity Lining; D003737:Dental Cavity Preparation; D003782:Dental Pulp / Q000187:drug effects; D003809:Dentin, Secondary; D003810:Dentinogenesis / Q000187:drug effects; D005289:Ferrets; D009804:Odontoblasts / Q000187:drug effects; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
chemical_list: D015035:Zinc Oxide-Eugenol Cement; D002126:Calcium Hydroxide