[Serum gastrin levels in colorectal cancers. Evolution after treatment].
Increased basal serum gastrin level has been described in patients presenting with colorectal cancer. The aim of this work was to study the evolution of serum gastrin levels after cancer treatment. We measured basal serum gastrin levels before and 1 to 2 months after treatment in 15 patients (7 men, 8 women; mean age: 61.6 years). There were 3 malignant polyps, 4 Dukes A, 3 Dukes B, 4 Dukes C and 1 Dukes D colonic cancers. Treatment included 3 endoscopic polypectomies, 2 laser photodestructions, and 10 surgical resections, Mean basal gastrin level after treatment (49.07 +/- 12.65 mIU/l) was significantly lower (P less than 0.002) than before treatment (104.47 +/- 26.98 mIU/l). In the 2 patients treated by laser therapy, recurrences were associated with reincreasing serum gastrin levels. These results suggest an "autocrine" secretion of gastrin.
Seitz
J F
JF
Service de Gastroentérologie, Institut Paoli-Calmettes, Marseille.
Giovannini
M
M
Monges
G
G
Sauvan
R
R
Wartelle
C
C
Martin
P
P
D000230:Adenocarcinoma / Q000097:blood* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003110:Colonic Neoplasms / Q000097:blood* / Q000601:surgery; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011182:Postoperative Care; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000097:blood* / Q000601:surgery; D013997:Time Factors
D005755:Gastrins
La gastrinémie dans les cancers colorectaux. Devenir après traitement.