A case of transfusion-associated graft-versus-host disease not prevented by white cell-reduction filters.
A case of transfusion-associated graft-versus-host disease (TA-GVHD) in a patient with non-Hodgkin's lymphoma is reported. The patient, a 67-year-old woman, was diagnosed as having diffuse, mixed type non-Hodgkin's lymphoma, at clinical stage IIIA. She was treated with combination chemotherapy and received multiple blood transfusions for anemia and thrombocytopenia. Although white cells (WBCs) were reduced in the transfused components by WBC-reduction filters, the patient developed TA-GVHD that was confirmed by skin biopsy. It is suggested that the WBC reduction attained with these filters does not prevent TA-GVHD in immunocompromised patients. It is recommended that all blood components should be irradiated before transfusion to such patients.
Akahoshi
M
M
Department of Hematology, Tokyo Women's Medical College, Japan.
Takanashi
M
M
Masuda
M
M
Yamashita
H
H
Hidano
A
A
Hasegawa
K
K
Kasajima
T
T
Shimizu
M
M
Motoji
T
T
Oshimi
K
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology; D002469:Cell Separation; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology* / Q000517:prevention & control; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D010976:Platelet Count; D065227:Transfusion Reaction
D006454:Hemoglobins