title: Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil.
abstract: After inhalation experiments with sandalwood oil and the pure fragrance compounds coumarin and alpha-terpineol, substances were detected and measured in the blood samples of test animals (mice) using gas chromatography/mass spectrometry (GC/MS) (MID) in connection with GC/FTIR (SWC), GC/AES (carbon and oxygen trace) and flame ionization detection/gas chromatography. Using tiglinic acid benzyl ester as the internal standard the following concentrations in serum could be found: alpha-santalol 6.1 ng/mL, beta-santalol 5.3 ng/mL and alpha-santalene 0.5 ng/mL. In separate inhalation experiments with coumarin and with alpha-terpineol the corresponding concentrations were 7.7 ng/mL and 6.9 ng/mL, respectively.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Vienna, Austria.
authors.forename: L
authors.initials: L
authors.lastname: Jirovetz
authors.forename: G
authors.initials: G
authors.lastname: Buchbauer
authors.forename: W
authors.initials: W
authors.lastname: Jäger
authors.forename: A
authors.initials: A
authors.lastname: Woidich
authors.forename: A
authors.initials: A
authors.lastname: Nikiforov
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D003374:Coumarins / Q000032:analysis*; D005410:Flame Ionization; D008401:Gas Chromatography-Mass Spectrometry; D051379:Mice; D009812:Odorants / Q000032:analysis; D010938:Plant Oils / Q000032:analysis*; D012717:Sesquiterpenes / Q000032:analysis*
chemical_list: D003374:Coumarins; D010938:Plant Oils; D012717:Sesquiterpenes; C076763:sandalwood oil