Gly145 to Arg substitution in HBs antigen of immune escape mutant of hepatitis B virus.
A Japanese child born to an HBeAg-positive carrier mother received anti-HBs immunoglobulins and a plasma-derived HBs vaccine with a poor anti-HBs-antibody response. The child, who is now 3 years old, is presently suffering from chronic hepatitis with unusual serological findings that are positive for HBsAg, anti-HBs and HBeAg, since being infected with a measles virus at 12 months of age. The nucleotide sequences of the S region of HBV DNA obtained from the patient, the mother and an HBeAg-positive brother were completely identical except for one nucleotide at position 587 (mother and brother: guanosine, patient: adenosine), giving an amino acid change: Gly - greater than Arg at position 145 of the major HBs protein.
Fujii
H
H
Ogaki Municipal Hospital, Minaminokawa, Japan.
Moriyama
K
K
Sakamoto
N
N
Kondo
T
T
Yasuda
K
K
Hiraizumi
Y
Y
Yamazaki
M
M
Sakaki
Y
Y
Okochi
K
K
Nakajima
E
E
D000595:Amino Acid Sequence; D001120:Arginine; D001483:Base Sequence; D002353:Carrier State; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D014644:Genetic Variation; D005998:Glycine; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000235:genetics*; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive; D007231:Infant, Newborn; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D014614:Vaccines, Synthetic / Q000008:administration & dosage; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D006513:Hepatitis B e Antigens; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines; D001120:Arginine; D005998:Glycine