title: Cardiovascular and plasma catecholamine responses at tracheal extubation.
abstract: The haemodynamic responses to tracheal extubation at the end of surgery were compared with those occurring at tracheal intubation in 12 patients undergoing major elective surgery. Arterial cannulation was performed and heart rate (HR), systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) were measured before induction of anaesthesia, before tracheal intubation, at the end of surgery and 1, 3 and 5 min after tracheal extubation. Laryngoscopy was avoided at the end of surgery. At all but the first of these stages, venous blood was obtained for measurement of plasma concentrations of adrenaline and noradrenaline. Rate-pressure product (RPP) was derived from SAP x HR. After tracheal intubation there were significant (P less than 0.05) increases in HR, DAP, RPP and in plasma concentrations of both adrenaline and noradrenaline. After extubation, only HR and adrenaline concentration at 5 min after extubation increased significantly compared with measurements at the end of surgery.
authors.affiliation: University Department of Anaesthesia, Leicester Royal Infirmary.
authors.forename: A
authors.initials: A
authors.lastname: Lowrie
authors.forename: P L
authors.initials: PL
authors.lastname: Johnston
authors.forename: D
authors.initials: D
authors.lastname: Fell
authors.forename: S L
authors.initials: SL
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001794:Blood Pressure / Q000502:physiology*; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006622:Hip Prosthesis; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*
chemical_list: D009638:Norepinephrine; D004837:Epinephrine