title: Defective production of interleukin-6 in very small premature infants in response to bacterial pathogens.
abstract: In the present study, a whole-blood culture was employed to examine the ability of preterm and term newborn infants to produce interleukin-6 (IL-6) in response to major bacterial pathogens such as group B streptococci, Escherichia coli, Listeria monocytogenes, and Streptococcus pneumoniae. Similarly, in response to stimulation with lipopolysaccharide, a potent stimulant for monocyte cytokine production, appreciable levels of IL-6 activity in the stimulated whole blood from term newborns as well as adults was effectively induced by all of these pathogens. In contrast to that of term infants, the bacteria-induced IL-6 production of preterm infants, especially those born before 30 weeks of gestation, was somewhat decreased (P less than 0.01 for each pathogen). It was also demonstrated that IL-6 responses to lipopolysaccharide stimulation were reduced in preterm newborns (for term versus preterm newborns less than 30 weeks of gestation, P was less than 0.01). These findings imply some inherent abnormality of monocytes in preterm babies. The diminished IL-6 production may be partly responsible for the susceptibility of preterm newborn infants to bacterial infections.
authors.affiliation: Department of Pediatrics, School of Medicine, Kanazawa University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yachie
authors.forename: N
authors.initials: N
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Uehara
authors.forename: S
authors.initials: S
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Miyawaki
authors.forename: N
authors.initials: N
authors.lastname: Taniguchi
mesh_terms: D000328:Adult; D001424:Bacterial Infections / Q000276:immunology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007234:Infant, Premature / Q000276:immunology*; D015850:Interleukin-6 / Q000096:biosynthesis*; D008070:Lipopolysaccharides / Q000633:toxicity*; D009000:Monocytes / Q000378:metabolism; D011247:Pregnancy
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides