Allogeneic transplantation of the radial side of the hand in the rhesus monkey: I. Technical aspects.
Since allogeneic transplantation of extremities can only be considered if uneventful long-term survival and functional recovery can be achieved, a series of 12 transplantations of the radial side of the hand were performed in rhesus monkeys so that these factors could be assessed. The transplant incorporated the first ray of the hand in conjunction with the radial forearm flap. Graft survival times varied from 21 to 179 days. Ten of 12 transplants showed rejection. In 2 of the 10, rejection could be reversed. Immunosuppressive therapy consisted of cyclosporin A, prednisone, monoclonal antibodies, and preoperative third-party blood transfusions. Monitoring of the microcirculation of the allograft could not provide a predictive value for transplant rejection. The first clinical signs of sensory and motor function recovery were detected after an average of 42 and 44 days, respectively. Indefinite uneventful allograft survival could not be established. Major complications such as sepsis, shock, and lymphoma development leading to death were encountered. The model, however, is technically feasible, and the results for functional recovery under immunosuppression are promising.
Hovius
S E
SE
Department of Plastic and Reconstructive Surgery, University Hospital Dijkzigt, The Netherlands.
Stevens
H P
HP
van Nierop
P W
PW
Rating
W
W
van Strik
R
R
van der Meulen
J C
JC
D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use; D005240:Feasibility Studies; D006084:Graft Rejection / Q000187:drug effects; D006085:Graft Survival; D006225:Hand / Q000502:physiology; D063987:Hand Transplantation; D008253:Macaca mulatta; D011183:Postoperative Complications; D011241:Prednisone / Q000627:therapeutic use; D011884:Radius; D012044:Regression Analysis; D014184:Transplantation, Homologous
D016572:Cyclosporine; D011241:Prednisone