title: Synthesis of dibenzoylmethane derivatives and inhibition of mutagenicity in Salmonella typhimurium.
abstract: Twenty dibenzoylmethanes with methyl, methoxy, bromo, chloro, or fluoro substitution on either one or both benzene rings were synthesized and assayed for inhibition of the mutagenicity of 2-nitrofluorene in S. typhimurium TA98. 2,2-Dimethoxy, 3,3-dimethoxy and 3,3,4,4-tetramethoxydibenzoylmethane was as active as dibenzoylmethane. None of the halogen-substituted dibenzoylmethanes were active. These results demonstrate that dibenzoylmethanes can inhibit the mutagenicity of 2-nitrofluorene, and that modifications made on the benzene rings of dibenzoylmethane cannot enhance the antimutagenicity of this parent compound.
authors.affiliation: Department of Pharmacy, Hiroshima General Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Choshi
authors.forename: S
authors.initials: S
authors.lastname: Horimoto
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Nagase
authors.forename: M
authors.initials: M
authors.lastname: Ichikawa
authors.forename: E
authors.initials: E
authors.lastname: Sugino
authors.forename: S
authors.initials: S
authors.lastname: Hibino
mesh_terms: D016587:Antimutagenic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D047188:Chalcones; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D016587:Antimutagenic Agents; D001565:Benzoates; D047188:Chalcones; C061481:dibenzoylmethane