The secretion of Duvernoy's gland of Malpolon monspessulanus induces haemorrhage in the lungs of mice.
A toxic protein that induces death of mice with profuse bleeding from the nostrils was isolated from the secretion of Duvernoy's gland of Malpolon monspessulanus (Colubridae). The toxic protein, referred to as CM-b, showed mainly one band on SDS-PAGE corresponding to a mol. wt of 24,000. Its intravenous LD50 in mice was 1 microgram/g and i.v. injections of lethal or sublethal doses induced haemorrhage in the lungs. When injected into the skin of mice, however, the toxin was not haemorrhagic. CM-b showed no proteolytic or procoagulant activity. The nature of this and other components from Duvernoy's secretion of colubrids that cause similar effects remains to be established.
Rosenberg
H I
HI
Department of Biology, University of Calgary, Alberta, Canada.
Kinamon
S
S
Kochva
E
E
Bdolah
A
A
D000818:Animals; D006470:Hemorrhage / Q000139:chemically induced*; D007928:Lethal Dose 50; D008171:Lung Diseases / Q000139:chemically induced*; D051379:Mice; D012910:Snake Venoms / Q000737:chemistry / Q000302:isolation & purification / Q000506:poisoning*
D012910:Snake Venoms