[Study of microcirculatory flow variations by laser Doppler velocimetry after cutaneous application of nitrated derivatives in normal subjects].
The local microcirculatory effect of percutaneous nitrate derivatives was evaluated by determining flux by laser Doppler in 10 controls. The application of Lenitral cream under the recording probe produced a rapid (within a mean of 6.7 min) elevation in the flux, reaching a maximum in 20 min and returning to baseline values in 55 minutes. This vasodilatory effect was maximal in the richly vascularized zones, but remained limited to the site of application of the nitrate derivatives, being undetectable even at a short distance from the application zone.
Ninet
J
J
Service d'Urgence Médicale et de Médecine Interne, Hôpital Edouard-Herriot, Lyon.
Fauveau
E
E
Schmitt
M
M
Bachet
P
P
Saumet
J L
JL
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D006801:Humans; D008833:Microcirculation / Q000187:drug effects*; D009566:Nitrates / Q000008:administration & dosage*; D012016:Reference Values; D012212:Rheology
D009566:Nitrates
Etude des variations du flux microcirculatoire par vélocimétrie Doppler au laser après application de dérivés nitrés cutanés chez le sujet sain.