Double-blind randomized trial of nicotinamide on early-onset diabetes.
OBJECTIVE
To determine the efficacy of nicotinamide in inducing remission in early-onset insulin-dependent diabetes mellitus.


METHODS
This study was a double-blind, randomized clinical trial.


CONCLUSIONS
Nicotinamide failed to induce remission or differences on beta-cell secretion between the two groups.
Lewis
C M
CM
Department of Medicine, School of Medicine, College of Pharmacy, University of Minnesota, Minneapolis 55455.
Canafax
D M
DM
Sprafka
J M
JM
Barbosa
J J
JJ
D015190:Blood Glucose Self-Monitoring; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004311:Double-Blind Method; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D009536:Niacinamide / Q000627:therapeutic use*; D012074:Remission Induction
D002096:C-Peptide; D006442:Glycated Hemoglobin; D009536:Niacinamide