[Evaluation of the efficacy of the combination amoxicillin-clavulanic acid-tobramycin for the prevention of infections after surgery for ORL cancers].
The clinic and economic evaluation of a probabilist antibiotherapy Augmentin/Nebcine administered until the wound healing was studied in 60 patients, operated of upper aerodigestives tracts cancer. The antibiotherapy efficiency was estimated at the end of 6 days in terms of clinic and bacteriologic results. In case of therapeutic failure, the treatment was adapted according to antibiogram results. The association Augmentin/Nebcine was effective in 93% of cases. Antibiotherapy was to be modified for five patients (one for allergy and four for bacteriological unsuccessful). The bacteriologic sample shows the predominance of Gram(-) germs. 83% of them were sensitive to one of these antibiotics in vitro. The daily mean cost of antibiotherapy was about FF 71. The overcost, due to antibiotherapy failures, represented only 1% of the whole cost of the 60 treatments. These results justify the use of a large spectrum antibiotherapy reaching Gram(-) germs.
Philip
V
V
Service Pharmacie, CHR de Bordeaux, Pessac.
Saux
M C
MC
Rovira
H
H
Boutin
F
F
Traissac
L
L
D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000517:prevention & control*; D002969:Clavulanic Acids / Q000627:therapeutic use*; D002985:Clinical Protocols; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010039:Otorhinolaryngologic Neoplasms / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D014031:Tobramycin / Q000627:therapeutic use*
D002969:Clavulanic Acids; D000658:Amoxicillin; D014031:Tobramycin
Evaluation de l'efficacité de l'association amoxicilline acide clavulanique-tobramycine pour la prévention des infections après chirurgie ORL pour cancer.