Influence of carbadox on fasting oxygen consumption by portal vein-drained organs and by the whole animal in growing pigs.
Fasting O2 consumption by the whole animal (W) and by portal vein-drained organs (PVDO) during the 24- to 30-h postprandial period were measured in seven growing pigs (36.1 +/- 2.3 kg) with catheters chronically placed in the hepatic portal vein, ileal vein, and carotid artery trained to consume 1.2 kg of a 16% CP corn soybean meal basal diet (B) once daily. The pigs were placed individually into an open-circuit, indirect calorimeter and connected to an arteriovenous (A-V) O2 difference analyzer for hourly simultaneous measurements of O2 consumption by W and PVDO. The PVDO O2 consumption was calculated by multiplying the A-V O2 difference by the portal vein blood flow rate derived from constant infusion of a p-aminohippuric acid solution into the ileal vein. After the initial series of hourly measurements, four pigs remained on the B diet and three pigs were fed a B + 55 ppm carbadox diet. Seven days later, the second series of measurements was made. In pigs fed the diet with carbadox added, the hourly W O2 consumptions were not different (P greater than .05) between the initial and second series and averaged 7.5 mL.min-1.kg of BW-1. However, the A-V O2 differences (mL/dL) were reduced (P less than .05) from 4.6 to 4.0 at 24 h, 4.8 to 4.0 at 25 h, and 4.6 to 4.0 at 29 h postprandial and the fractions of W O2 consumption used by PVDO (percentage) were reduced (P less than .05) from 28.6 to 21.6 at 26 h and 25.2 to 18.2 at 27 h postprandial.(ABSTRACT TRUNCATED AT 250 WORDS)
Yen
J T
JT
ARS, Roman L. Hruska U.S. Meat Animal Research Center, U.S. Department of Agriculture, Clay Center, NE 68933.
Nienaber
J A
JA
D000818:Animals; D001835:Body Weight; D002218:Carbadox / Q000494:pharmacology*; D004064:Digestive System / Q000378:metabolism*; D005260:Female; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects*; D010179:Pancreas / Q000378:metabolism; D011169:Portal Vein / Q000502:physiology; D012039:Regional Blood Flow; D013154:Spleen / Q000378:metabolism*; D013552:Swine / Q000378:metabolism*
D002218:Carbadox; D010100:Oxygen