title: Gliomyosarcoma: an immunohistochemical analysis.
abstract: Tumours of mixed glial and sarcomatous elements occurring in intracranial neoplasms are well recognised and have been termed gliosarcomas. These tumours account for up to 8% of all glioblastomas. The sarcomatous elements are thought to derive from the neoplastic transformation of mesenchymal cells in or adjacent to the tumour. This transformation usually has the appearance of a fibrosarcoma or angiosarcoma. Alternative mesenchymal neoplastic differentiation may occur, however, giving rise to the appearances of chondrosarcoma and osteosarcoma. In 1969 Goldman described a case in which the sarcomatous elements of a mixed gliosarcoma appeared, on the basis of light microscopy alone, to differentiate towards skeletal muscle having the features of a rhabdomyosarcoma. He coined the term gliomyosarcoma. In 1986 Barnard et al reported a second case and demonstrated the features of rhabdomyosarcoma using the electron microscope. A further case characterised with both light microscopic and immunohistochemical techniques is reported.
authors.affiliation: Department of Neurosurgery, Atkinson Morley's Hospital, Wimbledon, London, UK.
authors.forename: S R
authors.initials: SR
authors.lastname: Stapleton
authors.forename: W
authors.initials: W
authors.lastname: Harkness
authors.forename: P R
authors.initials: PR
authors.lastname: Wilkins
authors.forename: D
authors.initials: D
authors.lastname: Uttley
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D002283:Carcinoma, Bronchogenic / Q000473:pathology*; D003893:Desmin / Q000032:analysis; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005910:Glioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D009211:Myoglobin / Q000032:analysis; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D003893:Desmin; D005904:Glial Fibrillary Acidic Protein; D009211:Myoglobin; D014746:Vimentin