Protein kinase C increase in rat brain cortical membranes may be promoted by cognition enhancing drugs.
Protein Kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain cortices after in vivo treatment with two cognition enhancers: oxiracetam and alpha-glicerylphosphorylcholine. Both drugs induced an increase (+40-50%) of PKC particulate activity at 1 hr after the treatment. The effect was transient; at 5 hours PKC activity was lower than in controls. The dose response curve to oxiracetam was bell shaped, the increase of PKC being significant at 100 mg/kg. At higher doses the drug induced a decrease in enzyme activity. The increased PKC activity may be related to the cortical effects of these compounds.
Govoni
S
S
Pharmacobiology Dept., Univ. of Bari, Italy.
Lucchi
L
L
Battaini
F
F
Trabucchi
M
M
D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology*; D003071:Cognition / Q000187:drug effects; D003891:Desipramine / Q000494:pharmacology; D005997:Glycerylphosphorylcholine / Q000494:pharmacology*; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011759:Pyrrolidines; D005997:Glycerylphosphorylcholine; D011493:Protein Kinase C; C040619:oxiracetam; D003891:Desipramine