Ethanol inhibits C6 cell growth: fetal alcohol syndrome model.
Maternal consumption of ethanol produces a pattern of malformations, including nervous system abnormalities, in the developing fetus, a state called Fetal Alcohol Syndrome. We report the dose-dependent inhibition by ethanol of the growth of a glioma derived cell line, C6 cells; the effects occur at ethanol concentrations commonly encountered in the blood during human intoxication. The effects occur with different morphological subtypes of the cell line and do not occur when the cells are exposed to iso-osmolar concentrations of other chemicals. The results demonstrate that C6 cells are a model for the study of the effects of ethanol on nervous system cell growth.
Isenberg
K
K
Washington University School of Medicine, Department of Psychiatry, St. Louis, Missouri 63110.
Zhou
X
X
Moore
B W
BW
D001253:Astrocytes / Q000187:drug effects / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D063647:Fetal Alcohol Spectrum Disorders / Q000503:physiopathology*; D005910:Glioma; D006801:Humans; D008954:Models, Biological; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000502:physiology
D000431:Ethanol