title: Electric field-induced orientation of rat hippocampal neurones in vitro.
abstract: Rat hippocampal neurones in primary culture exhibited directional growth in response to DC electric fields. Neurites lay perpendicular to the field after exposure to 28, 80 or 219 mV/mm but there was no orientation effect at 9 mV/mm or in unexposed control cultures. Fields that evoked perpendicular responses also reduced the number of cathode-facing neurites. Orientation was the same for neurite initiation sites and the direction of overall neurite growth.
authors.affiliation: School of Biomedical Sciences, Division of Physiology, University of Aberdeen.
authors.forename: A M
authors.initials: AM
authors.lastname: Rajnicek
authors.forename: N A
authors.initials: NA
authors.lastname: Gow
authors.forename: C D
authors.initials: CD
authors.lastname: McCaig
mesh_terms: D000818:Animals; D004574:Electromagnetic Fields; D005333:Fetus / Q000166:cytology; D006624:Hippocampus / Q000166:cytology / Q000196:embryology*; D066298:In Vitro Techniques; D009474:Neurons / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains