title: Olfactory bulbectomy as a model for agitated hyposerotonergic depression.
abstract: Ablation of olfactory bulbs in rats reduced male sexual behavior, and altered the distribution of wheel-running activity between the light and dark phases of a 12:12 LD photoperiod. These effects were partially reversed by the tricyclic antidepressant amitriptyline. Olfactory bulbectomy also altered serotonin metabolism (5-HIAA/5-HT ratio) in the frontal cortex, nucleus accumbens, hippocampus and corpus striatum. These observations support the hypothesis that olfactory bulbectomy in rodents serves as a model of agitated hyposerotonergic depression.
authors.affiliation: Biopsychology Program, Skidmore College, Saratoga Springs, NY 12866.
authors.forename: A R
authors.initials: AR
authors.lastname: Lumia
authors.forename: M H
authors.initials: MH
authors.lastname: Teicher
authors.forename: F
authors.initials: F
authors.lastname: Salchli
authors.forename: E
authors.initials: E
authors.lastname: Ayers
authors.forename: B
authors.initials: B
authors.lastname: Possidente
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm / Q000187:drug effects; D003863:Depression / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009830:Olfactory Bulb / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000172:deficiency*; D012726:Sexual Behavior, Animal / Q000187:drug effects
chemical_list: D015306:Biogenic Monoamines; D000639:Amitriptyline; D012701:Serotonin