Revisiting and revising suppressor T cells.
A great deal of experimental evidence supports the phenomenon of immunological suppression. The molecular mechanisms to explain the phenomenology have, however, remained controversial. In this review, the data are reinterpreted in light of the recent advances in the understanding of T-cell subsets, the cross-regulatory properties of lymphokines and the differential presentation capacities of different antigen-presenting cell types.
Bloom
B R
BR
Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York, NY 10461.
Salgame
P
P
Diamond
B
B
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D008954:Models, Biological; D016176:T-Lymphocyte Subsets / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*