title: [Clinical use of a totally implantable and programmable pump for the infusion of drugs].
abstract: Totally implantable programmable systems allow preordained complex continuous infusion of drugs. Sixteen totally programmable implantable pumps (Medtronic DAD) have been implanted in fifteen advanced colorectal and renal cancer patients for continuous ia and iv sinusoidal Fudr infusion. Median duration of pump function was 125 days (range 46-468), there was observed only one case of malfunction device which required the implant of a new device, and three complications of pump pocket (seroma, hematoma and infection) without interrumption of chemotherapy for clinical causes. The use of totally implantable programmable systems provides and important clinical improvement in controlled long-term drugs administration improving quality of life and duration of chemotherapy.
authors.affiliation: Istituto di Clinica Chirurgica I, Università degli Studi di Genova.
authors.forename: N
authors.initials: N
authors.lastname: Balletto
authors.forename: M
authors.initials: M
authors.lastname: Cavallini
authors.forename: E
authors.initials: E
authors.lastname: Cortesi
authors.forename: F
authors.initials: F
authors.lastname: Decian
authors.forename: G B
authors.initials: GB
authors.lastname: Arnone
authors.forename: D
authors.initials: D
authors.lastname: Civalleri
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy; D005467:Floxuridine / Q000008:administration & dosage; D006801:Humans; D015918:Infusion Pumps, Implantable; D007680:Kidney Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D005467:Floxuridine
vernacular_title: Impiego clinico di una pompa totalmente impiantabile e programmabile per l'infusione di farmaci.