Histatins 2 and 4 are autoproteolytic degradation products of human parotid saliva.
Freshly collected human parotid saliva contains 8 cationic proteins, as demonstrated by capillary electrophoresis. These proteins include lysozyme, histatin 6 and the 6 salivary histidine-rich polypeptides (HRPs 1-6). Neither histatin 2 nor histatin 4 are present in native undegraded parotid saliva but appear only after autoproteolytic degradation of the saliva. Histatin 2 appears to arise through slow degradation of HRP-1, and histatin 4 is mainly produced as a rapid breakdown product of HRP-3.
Xu
L
L
School of Dental Medicine, State University of New York, Stony Brook.
Lal
K
K
Pollock
J J
JJ
D000595:Amino Acid Sequence; D006801:Humans; D008969:Molecular Sequence Data; D010306:Parotid Gland / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D000099053:Histidine-Rich Glycoprotein
D011506:Proteins; D012471:Salivary Proteins and Peptides; D000099053:Histidine-Rich Glycoprotein