Activity of clarithromycin against murine listeriosis.
In-vitro clarithromycin was more active than erythromycin against Listeria monocytogenes. The antibacterial action was bacteristatic. In normal adult mice infected with a virulent strain of L. monocytogenes clarithromycin was also more active than erythromycin. A rapid decrease in viable count was obtained, which was not achieved with erythromycin. Early treatment resulted in a complete abrogation of an immune response to L. monocytogenes. In immunocompromised, congenitally athymic (nude) mice, only a moderate effect on the bacterial numbers was observed, indicating that even in vivo the activity of the macrolides is bacteristatic.
Bauer
J
J
Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim.
Hof
H
H
D000818:Animals; D017291:Clarithromycin; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D007700:Kinetics; D008089:Listeria monocytogenes / Q000187:drug effects; D008088:Listeriosis / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D012016:Reference Values
D004917:Erythromycin; D017291:Clarithromycin