[Omeprazole and misoprostol in acute gastroduodenal pathology. Physiopathological and therapeutic considerations in a surgical study].
In a clinical study on acute gastroduodenal pathology, the authors checked the therapeutical efficacy of Omeprazole and Misoprostol in comparison with H2-Antagonists. The study shows how Omeprazole could reduce to a half the treatment period necessary for H2-Antagonists to determine duodenal ulcer healing. Compared with these drugs, Omeprazole represents a real therapeutical progress. However, Omeprazole did not change the actual indications for surgical treatment in gastroduodenal ulcer. In drug-induced erosive gastritis treatment, Misoprostol proved to be unable to replace H2-Antagonists advantageously.
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Istituto di Fisiologia Generale, Università degli Studi di Roma La Sapienza.
Fidanza
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Zechini
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D000208:Acute Disease; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use*; D009853:Omeprazole / Q000627:therapeutic use*; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery
D016595:Misoprostol; D009853:Omeprazole
L'omeprazolo e il misoprostol nella patologia acuta gastroduodenale. Considerazioni fisiopatologiche e terapeutiche da uno studio in ambiente chirurgico.