title: Deoxyribonucleic acid study on 2 XX male patients.
abstract: Two XX male patients were examined for the presence of 25 Y-specific loci using Southern blot analysis and polymerase chain reaction techniques. They were phenotypically normal male patients, although 1 had bilateral undescended testes and 1 had hypoplastic testes. The former patient had 10 of 11 loci on the short arm, while the latter lacked any of the 25 Y-specific loci. These findings may suggest the existence of a non-Y gene that is controlled by the testis-determining factor on the short arm of the Y chromosome and has a role in the testis formation in man.
authors.affiliation: Department of Urology, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Namiki
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: A
authors.initials: A
authors.lastname: Okuyama
authors.forename: S
authors.initials: S
authors.lastname: Nagafuchi
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagome
mesh_terms: D000328:Adult; D002648:Child; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009030:Mosaicism / Q000235:genetics*; D014960:X Chromosome
chemical_list: D004247:DNA