title: Photochemistry of tiaprofenic acid, a nonsteroidal anti-inflammatory drug with phototoxic side effects.
abstract: The phototoxic nonsteroidal anti-inflammatory drug tiaprofenic acid (1) is photolabile under aerobic conditions. Irradiation of a methanol solution of 1 under oxygen produces the photoproducts 2, 3, 4, and 5, and also produces a singlet oxygen as evidenced by trapping with 2,5-dimethylfuran.
authors.affiliation: Departamento de Quimica, Universidad Politécnica de Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Boscá
authors.forename: M A
authors.initials: MA
authors.lastname: Miranda
authors.forename: F
authors.initials: F
authors.lastname: Vargas
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000737:chemistry*; D006801:Humans; D010777:Photochemistry; D010787:Photosensitivity Disorders / Q000209:etiology; D011422:Propionates / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid