title: 2-Amino-2-oxazolines, V: Synthesis of some 5-dialkylaminomethyl-2-amino-2-oxazolines and evaluation of their diuretic activity.
abstract: A series of 5-dialkylaminomethyl-2-amino-2-oxazolines was prepared and screened for diuretic activity. These compounds were previously examined for their lipophilic behaviour using a reversed-phase HPLC technique. The capacity factors, expressed as log k'w, were correlated with the partition coefficient log P. A QSAR analysis of the diuretic activity in relation with the lipophilicity was attempted for these structurally related compounds.
authors.affiliation: Laboratoire de Pharmacologie, Université de Bordeaux II, France.
authors.forename: F
authors.initials: F
authors.lastname: Demotes-Mainard
authors.forename: J
authors.initials: J
authors.lastname: Tranchot
authors.forename: J
authors.initials: J
authors.lastname: Cambar
authors.forename: C
authors.initials: C
authors.lastname: Jarry
mesh_terms: D000818:Animals; D004232:Diuretics / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004232:Diuretics; D010080:Oxazoles