title: [Studies of diet management and insulin resistance in obese pregnant women].
abstract: In an attempt to determine the principles of diet management in obese pregnant women, the association between maternal weight gain during pregnancy (Group I; weight reduction, Group II; +0-4 kg, Group III; +5-9 kg, Group IV; +10 kg-) and the incidence of the complications was investigated in 151 obese pregnant women. Studies on glucose tolerance and insulin binding to erythrocytes were also undertaken. 1) In Group I, the incidences of C/S, forceps delivery, prolonged labor and complication of PIH were lower than those of other groups. There were no heavy-for-dates and light-for-dates babies in Group I, differing from the other three groups. 2) Plasma levels of glucose and insulin were high in obese pregnant women on 75 g OGTT in the second trimester. The binding sites of insulin to erythrocytes were significantly decreased in obese pregnant women. In conclusion, the risks of pregnancy complicated by obesity were high. Insulin resistance was a characteristic of obese pregnant women. The results of this study suggested that the nutritional requirements for very obese pregnant women should be restricted to maintaining the same weight or losing weight during the course of pregnancy to minimize maternal and perinatal risks.
authors.affiliation: Department of Obstetrics and Gynecology, Saitama Medical Center.
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Saitoh
authors.forename: K
authors.initials: K
authors.lastname: Kinoshita
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009751:Nutritional Requirements; D009765:Obesity / Q000178:diet therapy*; D011247:Pregnancy; D011248:Pregnancy Complications; D011972:Receptor, Insulin / Q000032:analysis; D015430:Weight Gain
chemical_list: D001786:Blood Glucose; D011972:Receptor, Insulin