title: Increased concentrations of type IV (7 S) collagen in sera of hyperthyroid patients with Graves disease.
abstract: Serum concentrations of type IV collagen (7 S) were determined in 29 patients with untreated hyperthyroidism and 30 healthy subjects. Serum 7 S collagen was significantly higher (P less than 0.0001) in the hyperthyroid patients (6.3, SD 1.3, micrograms/L) than in the healthy control subjects (3.9, SD 0.6, micrograms/L). No difference in serum concentrations of 7 S collagen were observed between patients with normal liver function and those with abnormal liver function. Serum concentrations of 7 S collagen correlated positively with serum concentrations of free triiodothyronine (r = 0.41, P less than 0.05). In the hyperthyroid patients, 7 S collagen concentrations in serum gradually fell into the normal range as thyroid function became normalized. Thus, hyperthyroidism is one of the diseases in which serum concentrations of 7 S collagen are increased.
authors.affiliation: Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shima
authors.forename: Y
authors.initials: Y
authors.lastname: Yano
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: M
authors.initials: M
authors.lastname: Misaki
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000097:blood*; D005260:Female; D006111:Graves Disease / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D015203:Reproducibility of Results; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D003094:Collagen