Audiogenic seizures induce c-fos in a model of developmental epilepsy.
In rats made susceptible to audiogenic seizures by exposing them to an intense noise at a critical time during development, subsequent noise exposure elicited seizures and induced the proto-oncogene c-fos in auditory regions of the brain. Cells showing Fos-like immunoreactivity were especially dense in dorsal and external cortices of the inferior colliculus, and were nearly absent after pretreatment with the N-methyl-D-aspartate (NMDA) antagonist MK-801. Noise exposure alone (i.e. no seizure) produced a localized zone of c-fos induction within the inferior colliculus, but only when presented during the time period when susceptibility to audiogenic seizures can be most effectively induced.
Snyder-Keller
A M
AM
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
Pierson
M G
MG
D000161:Acoustic Stimulation; D000375:Aging; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000503:physiopathology*; D004195:Disease Models, Animal; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004827:Epilepsy / Q000473:pathology / Q000503:physiopathology*; D015870:Gene Expression; D016762:Genes, fos; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000473:pathology / Q000503:physiopathology*
D016760:Proto-Oncogene Proteins c-fos; D016291:Dizocilpine Maleate