title: Oestrogen receptor and epidermal growth factor receptor expression in male breast carcinoma.
abstract: Male breast carcinomas are probably hormone-dependent, but receptor studies are few because this is a relatively rare tumour. We have studied 21 cases of male breast carcinoma immunohistochemically for oestrogen receptor (ER) and epidermal growth factor receptor (EGFR) expression employing the antibodies ER-ICA and 12E on formalin-fixed, paraffin-embedded material. In our series, 86 per cent of male breast cancers were ER-positive and 76 per cent were EGFR-positive. Male breast carcinomas do not exhibit the inverse correlation between ER and EGFR expression that characterizes female breast carcinomas. Owing to the limitations of a small series, we were unable to comment on the relationship between ER and EGFR expression and patient survival. However, the relatively high incidence of ER expression may provide a growth advantage for this tumour in a male environment characterized by low levels of oestrogen. In addition, high EGFR expression may also contribute to a poor prognosis independent of ER status.
authors.affiliation: Department of Pathology, University of Sheffield Medical School, U.K.
authors.forename: S B
authors.initials: SB
authors.lastname: Fox
authors.forename: S
authors.initials: S
authors.lastname: Rogers
authors.forename: C A
authors.initials: CA
authors.lastname: Day
authors.forename: J C
authors.initials: JC
authors.lastname: Underwood
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis*
chemical_list: D009363:Neoplasm Proteins; D011960:Receptors, Estrogen; D066246:ErbB Receptors