title: [Use of collagen in sealing of arterial puncture holes after heart catheterization].
abstract: Percutaneously introduced absorbable purified bovine collagen was used to plug the hole at the site of femoral arterial puncture in 50 patients (42 men, 8 women; median age 58 [22-75] after percutaneous coronary angiography (n = 32; heparin dosage 100 IU/kg) or transluminal coronary balloon dilatation (n = 18; heparin dosage 200 U/kg). Local bleeding ceased after compression of 4 min in 48 of the 50 patients. A pressure bandage was needed additionally in the other two. Bed-rest lasted for 1-24 (median 19) hours. A haematoma of more than 6 cm diameter developed in five patients, but required neither transfusion nor surgical intervention. 39 of the 50 patients were re-examined after a median of 39 days: all of them had had a small pain-free swelling for 2-6 weeks over the puncture site. One patient developed a deep-vein thrombosis one week after the procedure, in another fever occurred after the same period, lasting for two days. These early findings are encouraging. The method may significantly shorten the time of arterial compression and bed-rest, as well as reduce the risk of a large haematoma after arterial punctures.
authors.affiliation: Abteilung für Kardiologie, Universität Frankfurt, Main.
authors.forename: R
authors.initials: R
authors.lastname: Schräder
authors.forename: S
authors.initials: S
authors.lastname: Steinbacher
authors.forename: C
authors.initials: C
authors.lastname: Vallbracht
authors.forename: G D
authors.initials: GD
authors.lastname: Kneissl
authors.forename: M
authors.initials: M
authors.lastname: Kaltenbach
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D001158:Arteries / Q000293:injuries; D006328:Cardiac Catheterization; D002417:Cattle; D003094:Collagen; D017023:Coronary Angiography; D005260:Female; D005263:Femoral Artery / Q000293:injuries; D005500:Follow-Up Studies; D006490:Hemostatics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011677:Punctures / Q000009:adverse effects; D013997:Time Factors
chemical_list: D006490:Hemostatics; D003094:Collagen
vernacular_title: Kollagenapplikation zum Verschluss der arteriellen Punktionsstelle nach Herzkatheterisierung.