[Biologic activity and tolerance of a preparation of polyunsaturated fatty acids, obtained by a microbiological route ["biopolyene"]].
Biopolyene is a mixture of ethyl ethers of polyunsaturated fatty acids isolated from biomass of Entomophthora virulenta, a mycelial fungus. Its acute and chronic toxicity was studied on rats and guinea pigs. After oral administration of the preparation in single doses exceeding 50 g/kg there were no disorders in the general state of the rats. In chronic experiments with oral biopolyene in doses of 100 and 500 mg/kg and its local application to the intact skin of the animals in a dose of 1 g/kg there were no significant changes in the functional state of the liver and kidneys as well as the peripheral blood count. Insignificant changes in the serum levels of liver enzymes and coagulation were transient. The preparation showed no allergenic or immunomodulating effects. It had neither embryotoxic, teratogenic nor mutagenic action.
Dolgova
G V
GV
Berezhinskaia
V V
VV
Egorenko
G G
GG
Svinogeeva
T P
TP
Shtegel'man
L A
LA
Smolkina
T V
TV
Babanova
N K
NK
Ivanova
T V
TV
Nikitin
A V
AV
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D004361:Drug Tolerance / Q000502:physiology; D004773:Entomophthora / Q000378:metabolism*; D005019:Ethyl Ethers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000096:biosynthesis* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D014945:Wound Healing / Q000187:drug effects*
D005019:Ethyl Ethers; D005231:Fatty Acids, Unsaturated; C076759:biopolyene
Biologicheskaia aktivnost' i perenosimost' preparata polinenasyshchennykh zhirnykh kislot, poluchaemykh mikrobiologicheskim putem ["biopoliena"].