title: In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum.
abstract: The in vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline was compared against chloroquine-resistant and -susceptible strains of Plasmodium falciparum using a semi-micro drug susceptibility test. For each strain, the corresponding enantiomers exhibited similar activities. The enantiomers of halofantrine were the most active against both susceptible and resistant strains, followed by the enantiomers of mefloquine and enpiroline.
authors.affiliation: Department of Parasitology, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: L K
authors.initials: LK
authors.lastname: Basco
authors.forename: C
authors.initials: C
authors.lastname: Gillotin
authors.forename: F
authors.initials: F
authors.lastname: Gimenez
authors.forename: R
authors.initials: R
authors.lastname: Farinotti
authors.forename: J
authors.initials: J
authors.lastname: Le Bras
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015767:Mefloquine / Q000494:pharmacology*; D010616:Phenanthrenes / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D010616:Phenanthrenes; D011725:Pyridines; C023767:enpiroline; C023768:halofantrine; D015767:Mefloquine