Xanthomatous pseudotumor of the small intestine following treatment for Burkitt's lymphoma.
A 9-year-old boy with a large mass in the right lower quadrant of the abdomen was diagnosed as having disseminated Burkitt's lymphoma by pleural fluid aspirate. After 4 months of chemotherapy, he developed acute small-bowel obstruction. A resected ileal segment contained a bright-yellow annular submucosal tumor, histologically a xanthoma, that infiltrated the muscularis propria and serosa. No residual lymphoma was identified. We believe that the small-bowel xanthoma in this child is an unusual, nonneoplastic, treatment-related sequela of lymphoma cell lysis and histiocytic scavenging of lipid-membranous debris.
Ashfaq
R
R
Department of Pathology, University of Texas Southwestern Medical Center, Dallas.
Timmons
C F
CF
D002051:Burkitt Lymphoma / Q000188:drug therapy*; D002648:Child; D006801:Humans; D007410:Intestinal Diseases / Q000209:etiology* / Q000473:pathology; D007415:Intestinal Obstruction / Q000209:etiology; D007421:Intestine, Small / Q000473:pathology; D008297:Male; D014973:Xanthomatosis / Q000209:etiology* / Q000473:pathology