Influence of moclobemide on ibuprofen-induced faecal blood loss.
In a pharmacological screen on drug-drug interactions performed in laboratory animals moclobemide potentiated at high doses the antiphlogistic/anti-inflammatory activity of ibuprofen. Therefore, a study was undertaken to determine in healthy volunteers the faecal blood loss induced by multiple doses of ibuprofen (600 mg t.i.d.) in presence and absence of steady-state concentrations of concomitantly administered moclobemide (150 mg t.i.d.). The results show that multiple doses of moclobemide do not change faecal blood loss induced by ibuprofen. Furthermore, no clinically relevant pharmacokinetic interaction between the two drugs studied was detected.
Güntert
T W
TW
Department of Clinical Pharmacology, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Schmitt
M
M
Dingemanse
J
J
Jonkman
J H
JH
D001549:Benzamides / Q000493:pharmacokinetics / Q000494:pharmacology*; D004311:Double-Blind Method; D004357:Drug Synergism; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007052:Ibuprofen / Q000493:pharmacokinetics / Q000633:toxicity*; D020912:Moclobemide; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009780:Occult Blood
D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D020912:Moclobemide; D007052:Ibuprofen