Comparative metabolism of the cysteine and homocysteine conjugates of propachlor by in situ perfused kidneys of rats.
1. 14C-Cysteinyl- and homocysteinylpropachlor were metabolized to their respective mercapturic acids by rat kidneys in situ. First-pass elimination of 14C in urine was 47.5% for the cysteine conjugate and 36% for the homocysteine conjugate. 2. About half of the perfused 14C-labelled material isolated from urine from kidneys perfused with homocysteinylpropachlor was unchanged homocysteinylpropachlor and about half was the corresponding mercapturic acid. However, only the corresponding mercapturic acid and the S-oxide of this mercapturic acid (31.4% and 1.7% of the dose) were found in urine from kidneys perfused with cysteinylpropachlor, indicating that rat kidneys more efficiently acetylated the natural substrate, the cysteine conjugate.
Davison
K L
KL
US Department of Agriculture, Biosciences Research Laboratory, Fargo, ND 58105.
Bakke
J E
JE
Larsen
G L
GL
D000083:Acetanilides / Q000493:pharmacokinetics*; D000111:Acetylcysteine / Q000652:urine*; D000818:Animals; D010478:Chemotherapy, Cancer, Regional Perfusion; D003545:Cysteine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry; D006540:Herbicides / Q000493:pharmacokinetics*; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000083:Acetanilides; D006540:Herbicides; D006710:Homocysteine; C076663:homocysteinylpropachlor; C033735:2-(cysteine)-N-isopropylacetanilide; D003545:Cysteine; D000111:Acetylcysteine