[Structure and function of ventricular natriuretic peptide (VNP)].
Ventricular natriuretic peptide (VNP) appears to be a new member of the ANP family, as judged by its uniquely long C-terminal 'tail' sequence and by its cDNA sequence. The eel VNP causes the entire spectra of actions known to be characteristic of the ANP family, and its vascular and renal effects are more potent than other eel natriuretic peptides in both eels and rats. Since VNP is a hormone originating from ventricles, it is possible that VNP is secreted more quickly and profoundly than atrium-originated ANP, in response to an increase in afterload or stenosis of the coronary artery, resulting in recovery of ventricular function. Therefore, identification of VNP in mammals is awaited for the development of a new drug which counteracts against heart failure.
Takei
Y
Y
Department of Physiology, Kitasato University School of Medicine.
D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000737:chemistry* / Q000494:pharmacology / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D008969:Molecular Sequence Data; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
C068986:ventricular natriuretic peptide, eel; D009320:Atrial Natriuretic Factor; D012964:Sodium