[Potentiation of the effects of anxiolytics with magnesium salts].
In a double blind trial the authors tested the assumption that magnesium potentiates by its specific action the therapeutic effect of anxiolytics. A group of 20 women treated on account of anxious depressive neurosis was divided into two sub-groups. The first was given anxiolytic and placebo, the second one anxiolytics and Mg-lactate in corresponding amounts. After 10 days the placebo and Mg-lactate were exchanged. Both groups were examined before treatment and then after 10 and 20 days of therapy by a series of psychological tests. It was revealed that the combination of anxiolytics and Mg-lactate leads to a more rapid reduction of psychopathological symptoms, in particular anxiety. In MAS and MHG tests the decline of anxiety was statistically significant at the level of p less than 0.05.
Bocková
E
E
Psychiatrická klinika FN Plzen.
Hronek
J
J
Kolomazník
M
M
Polácková
J
J
Curdová
N O
NO
D000328:Adult; D003975:Diazepam / Q000008:administration & dosage*; D004311:Double-Blind Method; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007773:Lactates / Q000008:administration & dosage*; D019344:Lactic Acid; D008274:Magnesium / Q000008:administration & dosage; D008875:Middle Aged; D009497:Neurotic Disorders / Q000188:drug therapy*
D007773:Lactates; D019344:Lactic Acid; D008274:Magnesium; D003975:Diazepam
Potencování úcinků anxiolytik horecnatými solemi.