title: Autoimmune hemolytic anemia associated with anti-Sc1.
abstract: A case of autoimmune hemolytic anemia (AIHA) in a young child is described. The hemolysis was resistant to steroid therapy but responded to splenectomy and intravenous immunoglobulin. The autoantibody was shown to be anti-Sc1 by both serologic and immunoblotting techniques. This seems to be the first report of an autoanti-Sc1 detected by immunoblotting and the first example of AIHA in a child caused by autoanti-Sc1.
authors.affiliation: Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: I
authors.initials: I
authors.lastname: Owen
authors.forename: V
authors.initials: V
authors.lastname: Chowdhury
authors.forename: M E
authors.initials: ME
authors.lastname: Reid
authors.forename: J
authors.initials: J
authors.lastname: Poole
authors.forename: J C
authors.initials: JC
authors.lastname: Marsh
authors.forename: J M
authors.initials: JM
authors.lastname: Hows
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D017411:Ribonucleoproteins, Small Nuclear; D013156:Splenectomy; D055517:snRNP Core Proteins
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins