Facial pyogenic granuloma-like lesions under isotretinoin therapy.
A male patient with severe cystic acne was treated with 13-cis-retinoic acid in a dosage of 1 mg/kg/day. Early flare-up of his acne and multiple pyogenic-like lesions on his face appeared during the second week of isotretinoin treatment. Histologic study of the lesions revealed granulation tissue. Possible etiologies for this phenomenon are discussed.
Hagler
J
J
Department of Dermatology, Beilinson Medical Center, Petah Tiqva, Israel.
Hodak
E
E
David
M
M
Sandbank
M
M
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D005148:Facial Dermatoses / Q000139:chemically induced*; D006099:Granuloma / Q000139:chemically induced*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011711:Pyoderma / Q000139:chemically induced*
D015474:Isotretinoin