title: [Nonparametric normal range for thrombocyte parameters in childhood].
abstract: In order to establish an univariate nonparametric pediatric tolerance region platelet function has been investigated in 105 healthy children and adolescents. In comparison to adult normal values, the bleeding time is shortened, spontaneous platelet aggregation is enhanced as well as collagen-induced platelet aggregation. 30% of the children showed an increased disaggregation in ADP-induced aggregation. A slight delay was found in the spreading of thrombocytes. Platelet volume shifted to the left. Values of beta-thromboglobulin were raised. Compared to adult values no alterations could be found in platelet shape-change. Changes of platelet functions were more apparent in the younger children.
authors.affiliation: Zentrum der Kinderheilkunde, Stadtkrankenhaus Hanau, Main.
authors.forename: U
authors.initials: U
authors.lastname: Nowak-Göttl
authors.forename: E
authors.initials: E
authors.lastname: Besier
authors.forename: W D
authors.initials: WD
authors.lastname: Kreuz
authors.forename: R
authors.initials: R
authors.lastname: Linde
authors.forename: M
authors.initials: M
authors.lastname: Koert
authors.forename: H K
authors.initials: HK
authors.lastname: Breddin
authors.forename: B
authors.initials: B
authors.lastname: Kornhuber
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D001760:Bleeding Time; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D012016:Reference Values; D001620:beta-Thromboglobulin / Q000737:chemistry
chemical_list: D001620:beta-Thromboglobulin; D000244:Adenosine Diphosphate; D003094:Collagen
vernacular_title: Nichtparametrischer Normalbereich für thrombozytäre Parameter im Kindesalter.