The murine MHC encodes a mammalian homolog of bacterial ribosomal protein S13.
The mouse major histocompatibility complex (MHC) contains many genes in addition to the classical immune response genes. We have screened overlapping cosmid clones covering 170 kb of the H-2K region for genes expressed in embryonal carcinoma (EC) cells. The Ke-3 gene (Abe et al. 1988) found in this region was further studied by Southern, Northern, and sequence analysis. It is an expressed, intron-containing locus encoding a mouse homolog of the bacterial ribosomal protein S13. This is the first non-organelle S13 homolog identified in metazoans, and its genomic location has been determined precisely.
MacMurray
A J
AJ
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.
Shin
H S
HS
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D003001:Cloning, Molecular; D003360:Cosmids; D004247:DNA; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D012269:Ribosomal Proteins / Q000235:genetics*; D016415:Sequence Alignment; D014158:Transcription, Genetic
D012269:Ribosomal Proteins; D004247:DNA