title: [Enhancement of therapeutic efficacy of aclarubicin against lymph node metastases using a new dosage form: aclarubicin adsorbed on activated carbon particles].
abstract: Seven days after a subcutaneous inoculation of 5 x 10(5) P388 leukemia cells into the foot pad of the left hind paw of donor mouse, aclarubicin (0.2mg/kg body weight) was injected subcutaneously into the hind paw of the opposite foot pad in the form of ACR-CH or aclarubicin aqueous solution. On day 10, the left popliteal and the lower para-aortic lymph nodes taken from each donor were transferred intraperitoneally to a normal recipient mouse. The combined survival time of recipients and the viable P388 leukemia cell number in popliteal and para-aortic lymph nodes were estimated with a calibration formula. Our results showed that the survival curve of recipients given ACR-CH was statistically improved compared with that of other treatment groups.
authors.affiliation: First Dept. of Surgery, Kyoto Prefectural University of Medicine.
authors.forename: C
authors.initials: C
authors.lastname: Sakakura
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Sawai
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: M
authors.initials: M
authors.lastname: Shimotsuma
authors.forename: S
authors.initials: S
authors.lastname: Shobayashi
authors.forename: K
authors.initials: K
authors.lastname: Ozaki
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Tsujimoto
authors.forename: M
authors.initials: M
authors.lastname: Shirasu
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage*; D000818:Animals; D002244:Carbon / Q000008:administration & dosage; D016503:Drug Delivery Systems; D007941:Leukemia P388 / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000517:prevention & control*; D051379:Mice; D011205:Povidone / Q000008:administration & dosage
chemical_list: D002244:Carbon; D015250:Aclarubicin; D011205:Povidone