title: Treatment of acute profound heart failure by ventricular assist device.
abstract: Sixteen patients with acute profound heart failure (HF) have been treated with the left ventricular assist device (LVAD), nine of them were successfully weaned from LVAD, and three of them were discharged and survived longer. Decompression of the left ventricle (LV) at the beginning will prevent overextension of impaired myocardium and accelerate scar formation. Gradual increase of LV work will promote the compensation ability of the residual myocardium. We found that continuous LVAD assistance can give time for the impaired heart to recover while maintaining normal circulation. For patients with profound HF which is beyond the limit of intra-aortic balloon pumping's (IABP) capability, LVAD is a more powerful and effective means. Although the heart recovered, many patients later died of multiple organ failure (MOF) which was probably caused by prolonged ischemia before LVAD application. For completely successful recovery from profound HF, diagnosis and deciding to use LVAD should not be delayed. It should be applied before major organs including the heart itself suffer irreversible damage. We have established a systematic therapeutic concept of treating acute HF patients using assisted circulation including LVAD.
authors.affiliation: National Cardiovascular Center, Department of Artificial Organs, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takano
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Kitoh
authors.forename: K
authors.initials: K
authors.lastname: Hiramori
authors.forename: K
authors.initials: K
authors.lastname: Haze
authors.forename: A
authors.initials: A
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Manabe
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002303:Cardiac Output, Low / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D002675:Child, Preschool; D005069:Evaluation Studies as Topic; D005260:Female; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D015996:Survival Rate