title: Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures.
abstract: Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.
authors.affiliation: Department of Neurology, University Hospital, Lund, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Bengzon
authors.forename: S
authors.initials: S
authors.lastname: Söderström
authors.forename: Z
authors.initials: Z
authors.lastname: Kokaia
authors.forename: M
authors.initials: M
authors.lastname: Kokaia
authors.forename: P
authors.initials: P
authors.lastname: Ernfors
authors.forename: H
authors.initials: H
authors.lastname: Persson
authors.forename: T
authors.initials: T
authors.lastname: Ebendal
authors.forename: O
authors.initials: O
authors.lastname: Lindvall
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000502:physiology*; D016548:Prosencephalon / Q000033:anatomy & histology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism*
chemical_list: D009414:Nerve Growth Factors