Behavioral pharmacology of antagonists at 5-HT2/5-HT1C receptors.
The possible implication of 5-HT2 receptors in CNS disorders such as schizophrenia, anxiety and depression suggests that 5-HT2 antagonists may be useful in the treatment of these disorders. The present review examines behavioral procedures used to characterize 5-HT2 antagonist properties of compounds and behavioral models of clinical activity in which 5-HT2 antagonists have been reported to be active. The pharmacological profile of 5-HT2 receptors in part resembles that of 5-HT1C receptors. Responses that have been proposed to involve the activation of 5-HT1C receptors are examined for their usefulness to detect 5-HT1C antagonist properties of compounds; these responses would help to differentiate 5-HT2 from 5-HT1C antagonist activity.
Koek
W
W
Neurobiology Division, FONDAX-Groupe de Recherche SERVIER, Puteaux, France.
Jackson
A
A
Colpaert
F C
FC
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D006801:Humans; D012702:Serotonin Antagonists
D012702:Serotonin Antagonists