title: Limitations of clearance determination using the single sample distribution volume method. An error analysis on the basis of compartment models.
abstract: To investigate the error possibly contained in the single sample distribution volume method for the determination of renal clearance, a mathematical model was applied to describe the effect of changes in distribution volume, clearance, intravascular space, intracompartmental exchange and the time point of blood sampling. The method was found to be valid only under well-defined circumstances (Topt = 45 +/- 5 min, Cl = 390 +/- 50 ml/min, Vd = 16.7 +/- 4 l, alpha = 0.05.V1 ml/min, V1/Vd = 0.5 +/- 0.05) as shown in sample calculations. Two-compartment model-based error calculations demonstrate that this technique implies at best an uncertainty of +/- 10% or more. Whilst it can be used preferably in healthy, normal-weight adults, it is not applicable, without error, under all other circumstances.
authors.affiliation: Department of Nuclear Medicine, Medical School Hannover, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kotzerke
authors.forename: W
authors.initials: W
authors.lastname: Burchert
authors.forename: H
authors.initials: H
authors.lastname: Wiese
authors.forename: U
authors.initials: U
authors.lastname: von Smekal
authors.forename: H
authors.initials: H
authors.lastname: Hundeshagen
mesh_terms: D006801:Humans; D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid / Q000493:pharmacokinetics*; D008954:Models, Biological; D011866:Radioisotope Renography
chemical_list: D007457:Iodine Radioisotopes; D007465:Iodohippuric Acid