Stria vascularis ultrastructural pathology in the C3H/lpr autoimmune strain mouse: a potential mechanism for immune-related hearing loss.
The stria vascularis in the C3H/lpr autoimmune strain mouse was ultrastructurally examined in order to better understand the potential mechanisms by which systemic autoimmune disease affects the ear. The inner ear from C3H/lpr mice before disease onset and C3H/HeJ controls showed no apparent pathology. However, the stria vascularis from older C3H/lpr mice after systemic autoimmune disease onset showed considerable intercellular edema around the stria capillaries and thickening of the capillary basement membrane, compared to controls. These observations suggest that perivascular abnormalities, which are the hallmark of systemic autoimmune diseases, may underlie the stria dysfunction and hearing loss seen in autoimmune diseases in humans.
McMenomey
S O
SO
Department of Otolaryngology-Head and Neck Surgery, Oregon Hearing Research Center, Portland 97201-2997.
Russell
N J
NJ
Morton
J I
JI
Trune
D R
DR
D000818:Animals; D001327:Autoimmune Diseases / Q000473:pathology*; D001485:Basement Membrane / Q000276:immunology / Q000648:ultrastructure; D004195:Disease Models, Animal; D007758:Ear, Inner / Q000276:immunology / Q000648:ultrastructure; D006311:Hearing Disorders / Q000276:immunology*; D007105:Immune Complex Diseases / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D013316:Stria Vascularis / Q000276:immunology / Q000648:ultrastructure*