title: Long-term results of corpus cavernosum autoinjection therapy for chronic erectile dysfunction.
abstract: Between May 1985 and March 1992, 172 patients suffering from chronic erectile dysfunction (21-70 years old) underwent constant corpus cavernosum autoinjection therapy (CAT) with a standardized papaverine phentolamine mixture (16385 injections). Thereafter 41 patients continued CAT with the single agent papaverine (1257 injections). On the basis of both these 17642 protocol auto-injections, and over 6 years of experience with intracavernosal autoinjection therapy we conclude that, especially with the papaverine-phentolamine mixture, CAT constitutes an effective therapy (full rigidity in 95.8%) with tolerable side-effects for chronic erectile dysfunction when preceded by careful patient selection and thorough multi-disciplinary evaluation. This is especially so in the case of arterial and/or neurogenic aetiology of the erectile dysfunction. In addition, the contraindications must be strictly observed, the treatment and technique fully explained, and a regular follow-up instituted. CAT is generally well accepted by the patients and their partners (98.8%/97.6%) and has distinct positive effects on self-esteem (77.8%), performance anxiety (84.4%), and partnership (79.5%). The most serious side-effect was prolonged erection (25 out of 17642 injections). In 6 patients reversible fibrotic changes near the tunica albuginea were observed.
authors.affiliation: Abteilung Dermatologie, Bundeswehrkrankenhaus, Ulm, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Gall
authors.forename: C
authors.initials: C
authors.lastname: Sparwasser
authors.forename: W
authors.initials: W
authors.lastname: Bähren
authors.forename: W
authors.initials: W
authors.lastname: Scherb
authors.forename: R
authors.initials: R
authors.lastname: Irion
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety; D003075:Coitus; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010409:Penile Diseases / Q000188:drug therapy* / Q000523:psychology; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000187:drug effects; D010646:Phentolamine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D012646:Self Administration
chemical_list: D010208:Papaverine; D010646:Phentolamine