The low affinity receptor for IgE (CD23) in human: a multifunctional receptor/cytokine?
This review relates the molecular and the functional aspects of the low affinity IgE receptor for IgE (CD23), and the possible cooperation with additional cytokines, lipid mediators and/or pharmacological agents (i.e. beta 2-adrenoceptor agonists etc ...) that appear to be involved in the regulation of the IgE-dependent immune and inflammatory responses in human. The possible contribution of CD23 to the initiation and the development of various diseases is also discussed.
Dugas
B
B
Département d'Immunologie, Institut Henri Beaufour, Les Ulis, France.
Mencia-Huerta
J M
JM
Braquet
P
P
D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007109:Immunity / Q000502:physiology; D007073:Immunoglobulin E / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism; D011961:Receptors, Fc / Q000378:metabolism*; D017455:Receptors, IgE
D000944:Antigens, Differentiation, B-Lymphocyte; D016207:Cytokines; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E