title: A longitudinal study of plasma cortisol and depressive symptomatology by random regression analysis.
abstract: The authors utilized a random regression model to test the longitudinal relationship between depressive symptomatology and plasma cortisol levels obtained before and after the administration of dexamethasone in 62 affectively ill inpatients. This statistical model for longitudinal studies permits the inclusion of subjects with incomplete data as well as subjects measured at different time points. The most significant relationships were found between decreases in depressive symptoms and decreases in the 8:30 AM predexamethasone and the 4:00 PM postdexamethasone cortisol values. Patients were also classified as responders or nonresponders, and the rate of change in several plasma cortisol measures were separately analyzed for these two groups. No differences in the rate of change in plasma cortisol levels were found between responders and nonresponders. These results suggest that the decreases in cortisol production associated with clinical improvement may be partially explained by a regression toward the mean effect. Some of the possible explanations for these results are discussed.
authors.affiliation: Illinois State Psychiatric Institute, Department of Central Research, Chicago 60612.
authors.forename: R
authors.initials: R
authors.lastname: Sharma
authors.forename: D
authors.initials: D
authors.lastname: Hedeker
authors.forename: G
authors.initials: G
authors.lastname: Pandey
authors.forename: P
authors.initials: P
authors.lastname: Janicak
authors.forename: J
authors.initials: J
authors.lastname: Davis
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy; D003907:Dexamethasone; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012044:Regression Analysis
chemical_list: D000928:Antidepressive Agents; D003907:Dexamethasone; D006854:Hydrocortisone