title: [Thrombolysis-block technique--a new local form of treatment of distal venous and arterial occlusions of the leg].
abstract: Lysis-block technique is a new treatment form for deep vein and arterial thrombosis. A strictly local lysis is achieved by using "BIERS blockade" combined with a peripheral intravenous injection of the lytic substance. The new technique is demonstrated on four patients. Two patients had popliteal vein thrombosis. One patient was treated with urokinase. The other patient (unsuccessfully) with urokinase and (subsequently) successfully with rt-PA. In both cases full recanalization of the vessels was achieved. Two patients had occlusions of lower leg arteries. Clinically and angiographically perfusion could be distinctively improved by fibrinolytic treatment with urokinase. Analysis of fibrinogen and plasminogen levels showed no systemic fibrinolytic effect. This was of importance in one patient with a meningioma and in another patient with peptic ulcers of the stomach where otherwise no fibrinolysis would have been possible. Thus, lysis-block-therapy is an important new alternative to systemic fibrinolytic treatment especially in those patients with contraindications for systemic lysis.
authors.affiliation: Geriatrische Klinik, Städtische Kliniken Duisburg.
authors.forename: T
authors.initials: T
authors.lastname: Heimig
authors.forename: M
authors.initials: M
authors.lastname: Martin
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography / Q000187:drug effects; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D015912:Thrombolytic Therapy / Q000295:instrumentation*; D013924:Thrombophlebitis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator
vernacular_title: Lyseblock-Technik--eine neue lokale Behandlungsform von Unterschenkelvenen- und-arterienverschlüssen.