Synthesis of alkylphosphonates, a new class of antineoplastic agents.
Three different phosphonate analogues of hexadecylphosphocholine, a representative of a new class of antineoplastic agents, were synthesized. The structures of the newly synthesized compounds have been devised to contain only one cleavage point for either phospholipase C or phospholipase D. These structural features should allow an examination of the importance of these enzymes for the antineoplastic activities of alkylphosphocholines.
Ries
U J
UJ
Max-Planck-Institute for Biophysical Chemistry, Dept. 145, Göttingen, FRG.
Fleer
E A
EA
Eibl
H
H
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D063065:Organophosphonates / Q000138:chemical synthesis*; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000138:chemical synthesis
D000970:Antineoplastic Agents; D063065:Organophosphonates; D010767:Phosphorylcholine; C039128:miltefosine