Evaluation of a bilayer artificial skin capable of sustained release of an antibiotic.
A bilayer artificial skin, composed of an upper silicone sheet and a lower collagen sponge, has been developed by modifying a technique proposed by Yannas and Burke. We have applied it clinically with success, but infection sometimes occurred in the area where the artificial skin was placed. To use it safely in an infected wound, we developed a new type of artificial skin capable of sustained release of antibiotic. Microspheres of poly-L-lactic acid containing an antibiotic, were installed in the upper silicone sheet. The usefulness of the new type of artificial skin was suggested by in vitro studies.
Matsuda
K
K
Department of Plastic Surgery, Faculty of Medicine, Kyoto University, Japan.
Suzuki
S
S
Isshiki
N
N
Yoshioka
K
K
Wada
R
R
Hyon
S H
SH
Ikada
Y
Y
D001672:Biocompatible Materials; D001684:Biological Dressings; D003692:Delayed-Action Preparations; D006801:Humans; D008422:Materials Testing; D008863:Microspheres; D012867:Skin; D014031:Tobramycin / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D014031:Tobramycin