title: Pharmacokinetics of lorazepam in critically ill neonates with seizures.
abstract: Pharmacokinetic data were evaluated in 10 term neonates with seizures after intravenous administration of lorazepam, 0.05 mg/kg or 0.1 mg/kg. All seizure activity ceased, with no adverse effects. Pharmacokinetic data revealed a decreased volume of distribution and clearance, and a prolonged half-life in comparison with data from older children and adults. These findings are consistent with physiologic differences in the neonate.
authors.affiliation: Department of Pediatrics, Lutheran General Children's Medical Center, Park Ridge, Illinois.
authors.forename: C A
authors.initials: CA
authors.lastname: McDermott
authors.forename: A L
authors.initials: AL
authors.lastname: Kowalczyk
authors.forename: E R
authors.initials: ER
authors.lastname: Schnitzler
authors.forename: H H
authors.initials: HH
authors.lastname: Mangurten
authors.forename: K A
authors.initials: KA
authors.lastname: Rodvold
authors.forename: S
authors.initials: S
authors.lastname: Metrick
mesh_terms: D016638:Critical Illness; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007275:Injections, Intravenous; D008140:Lorazepam / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D008140:Lorazepam