Candida infection with and without nystatin prophylaxis. A 11-year experience with patients with burn injury.
The incidence of opportunistic infections after thermal injury is high. Since 1985, we have been practicing Candida prophylaxis using nystatin "swish-and-swallow" and topical therapy. Patients treated between 1980 and 1984 served as controls and received no Candida prophylaxis. Although mean burn size, full-thickness injury, and age were comparable, the incidence of Candida colonization (26.7% vs 15.6%), infection (21.3% vs 10.0%), and sepsis (12.2% vs none) was significantly different between control and nystatin-treated groups, respectively. With prophylaxis, the incidence of Candida wound infection has been significantly reduced, and systemic candidiasis has been eradicated, eliminating the need for toxic systemic antifungal agents.
Desai
M H
MH
Shriners Burns Institute-Galveston, TX 77550.
Rutan
R L
RL
Heggers
J P
JP
Herndon
D N
DN
D000278:Administration, Buccal; D000287:Administration, Topical; D002056:Burns / Q000150:complications* / Q000401:mortality; D002177:Candidiasis / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D016469:Fungemia / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D006801:Humans; D009761:Nystatin / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies; D014946:Wound Infection / Q000209:etiology / Q000517:prevention & control*
D009761:Nystatin