[Fenofibrate-induced acute hepatitis with pseudo-cholangitis].
We report the case of acute hepatitis probably due to fenofibrate. Clinical features included abdominal pain and fever. Serum aminotransferases and alkaline phosphatase activities were moderately increased. Rechallenge induced a relapse of the symptoms and liver test abnormalities. High levels of eosinophils were present in the blood and in the liver suggesting an immunoallergic mechanism. Fenofibrate withdrawal was rapidly followed by favorable outcome.
Lelouch
S
S
Service des Maladies du Foie et de l'Appareil Digestif, Hôpital de Bicêtre, Le Kremlin Bicêtre.
Pelletier
G
G
Sinico
M
M
Ducreux
M
M
Etienne
J P
JP
D015746:Abdominal Pain / Q000209:etiology*; D000208:Acute Disease; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000473:pathology; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D011345:Fenofibrate / Q000009:adverse effects* / Q000627:therapeutic use; D005334:Fever / Q000209:etiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male
D011345:Fenofibrate
Hépatite aiguë pseudo-angiocholitique au fénofibrate.