Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals.
311 chemicals were tested under code, for mutagenicity, in Salmonella typhimurium; 35 of the chemicals were tested more than once in the same or different laboratories. The tests were conducted using a preincubation protocol in the absence of exogenous metabolic activation, and in the presence of liver S-9 from Aroclor-induced male Sprague-Dawley rats and Syrian hamsters. Some of the volatile chemicals were also tested in desiccators. A total of 120 chemicals were mutagenic or weakly mutagenic, 3 were judged questionable, and 172 were non-mutagenic. The remaining 16 chemicals produced different responses in the two or three laboratories in which they were tested. The results and data from these tests are presented.
Zeiger
E
E
Experimental Carcinogenesis and Mutagenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.
Anderson
B
B
Haworth
S
S
Lawlor
T
T
Mortelmans
K
K
D000818:Animals; D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity*; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects*
D002273:Carcinogens; D009153:Mutagens