Extrarenal sorbitol clearance after liver transplantation.
Extrarenal sorbitol clearance was measured in liver transplant patients after a steady-state perfusion. Four measurements were performed in 3 patients with various liver diseases (beginning or patent acute rejection, cytomegalovirus hepatitis, hepatic metastasis). The mean (+/- SD) extrarenal sorbitol clearance was 14.8 +/- 0.1 ml/min.kg. In 5 patients with minimal or no liver abnormalities, the mean from 5 measurements of extrarenal sorbitol clearance was 18.9 +/- 5.0 ml/min.kg. Extrarenal sorbitol clearance values in this later group were higher than the values previously reported in healthy subjects.
Paintaud
G
G
Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon.
Miguet
J P
JP
Bresson-Hadni
S
S
Gillet
M
M
Mantion
G
G
Bechtel
P
P
D000328:Adult; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011183:Postoperative Complications / Q000378:metabolism; D011184:Postoperative Period; D013012:Sorbitol / Q000493:pharmacokinetics*
D013012:Sorbitol