title: Second messenger signalling in olfaction.
abstract: The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the reaction cascades (desensitization). Recent evidence suggests that secondary reactions in olfaction (adaptation) may also be controlled by second messengers.
authors.affiliation: University of Stuttgart-Hohenheim, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Breer
authors.forename: I
authors.initials: I
authors.lastname: Boekhoff
mesh_terms: D000818:Animals; D006801:Humans; D015290:Second Messenger Systems / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D012903:Smell / Q000502:physiology*