title: Pharmacokinetic and metabolic aspects of the moclobemide-food interaction.
abstract: The effect of a protein-rich meal on the pharmacokinetics of moclobemide was studied after intravenous (75 mg) and oral (100 mg) administrations of this selective MAO-A inhibitor to eight healthy male volunteers. The meal chosen did not affect plasma concentration-time curves of the drug after oral administration apparently, because the influence of blood flow changes to the liver on hepatic first-pass metabolism (AUC increases) and on systemic clearance (AUC decreases) balance each other out.
authors.affiliation: Department of Anaesthesia, Mount Sinai Hospital, Toronto, Canada.
authors.forename: A F
authors.initials: AF
authors.lastname: Cole
authors.forename: J G
authors.initials: JG
authors.lastname: Baxter
authors.forename: B J
authors.initials: BJ
authors.lastname: Jackson
authors.forename: P
authors.initials: P
authors.lastname: Hew-Wing
authors.forename: T W
authors.initials: TW
authors.lastname: Güntert
authors.forename: D
authors.initials: D
authors.lastname: Lalka
mesh_terms: D000293:Adolescent; D000328:Adult; D001549:Benzamides / Q000493:pharmacokinetics*; D001682:Biological Availability; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology; D005502:Food; D006801:Humans; D007208:Indocyanine Green; D007275:Injections, Intravenous; D008102:Liver Circulation / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D020912:Moclobemide
chemical_list: D001549:Benzamides; D004044:Dietary Proteins; D007208:Indocyanine Green; D020912:Moclobemide