title: The effect of A23187 on glucose production from methylglyoxal and pyruvate in isolated murine hepatocytes.
abstract: 1. A23187 increased the glucose production from methylglyoxal in isolated hepatocytes, and maximal stimulation was obtained at 10(-6) M. The effect of A23187 was dependent on the presence of Ca2+. 2. Glucose production from pyruvate (less than 1 mM) in isolated hepatocytes was stimulated by A23187 in the presence of 2.5 mM Ca2+ and was depressed at pyruvate concentrations above 1 mM. Both the virtual Km and the virtual Vmax of glucose production from pyruvate were decreased by A23187.
authors.affiliation: Semmelweis University, Medical School, First Institute of Biochemistry, Budapest, Hungary.
authors.forename: M P
authors.initials: MP
authors.lastname: Kalapos
authors.forename: P
authors.initials: P
authors.lastname: Riba
authors.forename: T
authors.initials: T
authors.lastname: Garzó
authors.forename: F
authors.initials: F
authors.lastname: Antoni
authors.forename: J
authors.initials: J
authors.lastname: Mandl
mesh_terms: D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D005943:Gluconeogenesis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D011765:Pyruvaldehyde / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism*; D019289:Pyruvic Acid
chemical_list: D011773:Pyruvates; D000001:Calcimycin; D004533:Egtazic Acid; D011765:Pyruvaldehyde; D019289:Pyruvic Acid; D002118:Calcium