Role of fatty acid metabolites in the development of myocardial ischemic damage.
1. The review deals with possible mechanisms by which fatty acids amplify ischemic damage in myocardium. 2. The accumulation of free fatty acids, long chain acyl CoA and carnitine esters during hypoxia and their effects on various enzymatic systems are discussed. 3. Findings on the influence of exogenous fatty acids as well as observations concerning an inhibition of fatty acid degradation are also considered. 4. Finally the role of an oxygen steal effect, as an indirect mechanism for the fatty acid induced amplification of ischemic damage, is discussed.
Hütter
J F
JF
Pharmakologisches Institut, Bayer AG, Wuppertal, Fed. Rep. Germany.
Soboll
S
S
D000818:Animals; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology*; D005227:Fatty Acids / Q000378:metabolism* / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000648:ultrastructure; D010101:Oxygen Consumption / Q000187:drug effects
D005227:Fatty Acids