Double 20q- anomaly in myelodysplastic syndrome.
Two patients with myelodysplastic syndrome (MDS) whose bone marrow (BM) cells contained duplicate 20q- chromosomes are reported. No particular differences between the hematologic findings of four patients with single 20q- and the two patients with double 20q- chromosomes were noted. No differences in breakpoints on the 20q- chromosome were noted in these six patients, and the breakpoint was identified as 20q11. The presence of double 20q- chromosomes in MDS patients suggests, however, that the deleted chromosome has oncogenic activity.
Ohyashiki
K
K
First Department of Internal Medicine, Tokyo Medical College, Japan.
Murakami
T
T
Ohyashiki
J H
JH
Kodama
A
A
Sakai
N
N
Ito
H
H
Toyama
K
K
D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002890:Chromosomes, Human, Pair 20; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology*