title: Platelet activation and vascular damage in gestational hypertension.
abstract: Increased plasma fibronectin levels are a highly sensitive and specific predictor of gestational hypertension. Of a total of 105 apparently healthy normotensive primigravid women seen at the outpatient clinic, 10 with increased plasma levels of fibronectin (mean +/- 2 SD), were compared with 14 controls. Parameters of early vascular damage (laminin, preprocollagen III), platelet activation (beta-thromboglobulin, platelet factor 4), and coagulation (thrombin-antithrombin III complexes, fibrinopeptide A) were measured at regular (weekly or monthly) intervals. Abnormal values of laminin (p less than 0.005) and fibronectin (p less than 0.0001) were found up to 4 weeks before the onset of clinical disease. Levels of beta-thromboglobulin (p less than 0.0001) were also elevated at least 4 weeks before the appearance of clinical symptoms. Our results show that increased levels of laminin, fibronectin, and platelet activation, as indicated by beta-thromboglobulin levels, are preclinical features of gestational hypertension and indicate that vascular damage has occurred. Fibrin formation would appear to occur later.
authors.affiliation: Department of Obstetrics and Gynecology, A.Z. Sint-Jan, Brugge, Belgium.
authors.forename: V C
authors.initials: VC
authors.lastname: Ballegeer
authors.forename: B
authors.initials: B
authors.lastname: Spitz
authors.forename: L A
authors.initials: LA
authors.lastname: De Baene
authors.forename: A F
authors.initials: AF
authors.lastname: Van Assche
authors.forename: M
authors.initials: M
authors.lastname: Hidajat
authors.forename: A M
authors.initials: AM
authors.lastname: Criel
mesh_terms: D001777:Blood Coagulation; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005353:Fibronectins / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000473:pathology; D007797:Laminin / Q000097:blood; D015539:Platelet Activation; D011225:Pre-Eclampsia / Q000097:blood / Q000209:etiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood* / Q000473:pathology; D011446:Prospective Studies; D001620:beta-Thromboglobulin / Q000378:metabolism
chemical_list: D005353:Fibronectins; D007797:Laminin; D001620:beta-Thromboglobulin