Fc gamma RII, but not erythropoietin or GM-CSF, mediates calcium mobilization in fetal hemopoietic blast cells.
A proportion of fetal liver hemopoietic blast cells express Fc gamma RII, and addition of the anti-Fc gamma RII monoclonal antibody CIKM5 induces a rise in calcium in these cells in suspension. Although these cells are thus capable of mobilizing intracellular calcium in response to surface receptor mediated events, neither granulocyte-macrophage colony-stimulating factor (GM-CSF) nor erythropoietin produced detectable changes in intracellular calcium ion concentration in these cells.
Jones
H M
HM
Department of Haematology, University College and Middlesex School of Medicine, University College London, England.
Edelman
P
P
Pilkington
G R
GR
Watts
M
M
Linch
D C
DC
D000911:Antibodies, Monoclonal / Q000276:immunology; D000943:Antigens, Differentiation / Q000276:immunology / Q000502:physiology*; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D002460:Cell Line; D004921:Erythropoietin / Q000494:pharmacology*; D005333:Fetus / Q000166:cytology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism / Q000473:pathology; D007951:Leukemia, Myeloid / Q000378:metabolism / Q000473:pathology; D015473:Leukemia, Promyelocytic, Acute / Q000378:metabolism / Q000473:pathology; D011961:Receptors, Fc / Q000276:immunology / Q000502:physiology*; D017452:Receptors, IgG; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D011961:Receptors, Fc; D017452:Receptors, IgG; D004921:Erythropoietin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D002118:Calcium