title: Monitoring of serum KL-6 antigen in a patient with radiation pneumonia.
abstract: Serum marker KL-6 antigen has been reported to be a valuable indicator of the disease activity of interstitial pneumonia. It is not clear how sensitive the serum KL-6 antigen level is in reflecting histologic changes in lung tissues. We report here the results of serial measurements of serum KL-6 antigen in a 76-year-old male patient with radiation pneumonia. Serum KL-6 antigen levels were more sensitive than lactate dehydrogenase and procollagen type III N-terminal peptide. The level of serum KL-6 antigen appears to reflect the histologic changes of the lung more sensitively than does C-reactive protein.
authors.affiliation: Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: N
authors.initials: N
authors.lastname: Kohno
authors.forename: M
authors.initials: M
authors.lastname: Akiyama
authors.forename: K
authors.initials: K
authors.lastname: Hiwada
mesh_terms: D000368:Aged; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006023:Glycoproteins; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D011658:Pulmonary Fibrosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D011832:Radiation Injuries / Q000175:diagnosis*; D011859:Radiography
chemical_list: D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase