Reduced response to hepatitis B virus vaccination in boys with steroid-sensitive nephrotic syndrome.
Vaccination against hepatitis B virus (HBV) was performed in 18 boys (aged 5.7 +/- 2.4 years) suffering from steroid-sensitive nephrotic syndrome (SSNS) and in a control group of 21 healthy boys (aged 5.6 +/- 3.8 years). The percentage of patients who responded to vaccination was significantly lower than the control group 1, 6, 8, 12, 18 and 24 months after the start of vaccination. The titre of antibodies to HBV surface antigen produced by responders at 6 and 24 months was significantly lower in patients than in the control group. Boys with SSNS have an impaired response to HBV vaccination.
La Manna
A
A
Department of Paediatrics, University of Naples, Italy.
Polito
C
C
Foglia
A C
AC
Di Toro
A
A
Cafaro
M R
MR
Del Gado
R
R
D002675:Child, Preschool; D006509:Hepatitis B / Q000517:prevention & control* / Q000628:therapy; D006510:Hepatitis B Antibodies / Q000032:analysis / Q000276:immunology; D006511:Hepatitis B Antigens / Q000032:analysis / Q000276:immunology; D017325:Hepatitis B Vaccines; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000592:standards; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000276:immunology* / Q000503:physiopathology; D013997:Time Factors; D014611:Vaccination; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage*
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D017325:Hepatitis B Vaccines; D014761:Viral Hepatitis Vaccines