title: Low and variable presence of valproic acid in human brain.
abstract: We studied the distribution of valproic acid (VPA) between brain (gray matter) and serum in 13 patients receiving chronic VPA therapy who underwent cortical resections for intractable seizures. Valproate concentration in cerebral cortex was remarkably low compared with either total or unbound valproate concentration in serum. The respective brain-to-serum partition ratios based on total and free drug in serum were 0.111 +/- 0.051 and 0.544 +/- 0.175. In comparison with other commonly used antiepileptic drugs, valproate has the distinction of exhibiting the lowest brain-to-blood partitioning. Moreover, the brain-to-serum concentration ratio varied over a four-fold range between patients. Some of this variability was related to variation in serum protein binding, as indicated by a modest correlation between the partition ratio and serum free fraction (r = +0.687). However, the brain-to-unbound concentration ratio still showed a three-fold variation. The variability in distribution of VPA between brain and blood is probably one of the underlying factors for the lack of a clearly definable therapeutic range of serum VPA concentration in epileptic patient populations.
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of Washington, Seattle 98195.
authors.forename: D D
authors.initials: DD
authors.lastname: Shen
authors.forename: G A
authors.initials: GA
authors.lastname: Ojemann
authors.forename: R L
authors.initials: RL
authors.lastname: Rapport
authors.forename: R L
authors.initials: RL
authors.lastname: Dills
authors.forename: P N
authors.initials: PN
authors.lastname: Friel
authors.forename: R H
authors.initials: RH
authors.lastname: Levy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001923:Brain Chemistry; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000188:drug therapy / Q000378:metabolism*; D014635:Valproic Acid / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use
chemical_list: D014635:Valproic Acid