Hormonal responses to ingesting water or a carbohydrate beverage during a 2 h run.
Ingestion of fluids providing carbohydrate and electrolytes extends endurance times during prolonged exercise. To understand the contribution of these factors, we examined hormonal, physiologic, and metabolic responses to ingesting water (W) or a 7% glucose polymer/fructose/electrolyte solution (GPFE) in 10 men (age: 30 +/- 2 yr, VO2max: 57.4 +/- 3.2 ml.kg-1.min-1) who ran on a treadmill for 2 h at 60-65% of their VO2max. Subjects drank 200 ml of W or GPFE at 0-time and every 30 min while running (30,60, and 90 min). Changes in serum sodium, potassium, and osmolality; heart rate; plasma lactate and glucose; and serum insulin and plasma norepinephrine were similar for both fluid treatments. In contrast, changes in serum free fatty acids (FFA), plasma cortisol, and arginine vasopressin (AVP) differed across fluid treatments: with GPFE, exercise abolished the rise in plasma cortisol, and attenuated the rise in both AVP and FFA. The observed suppression of cortisol and AVP was not related to changes in any of the parameters examined, but were strongly correlated with each other. These findings suggest that adding carbohydrate and electrolytes to fluids ingested during prolonged exercise decreases activation of the hypothalamic-pituitary-adrenal axis, a potentially beneficial change. However, mobilization of FFA was also decreased. The mechanism by which they occur remains elusive.
Deuster
P A
PA
Department of Military Medicine, Uniformed Services University of the Health Sciences School of Medicine, Behtesda, MD 20814.
Singh
A
A
Hofmann
A
A
Moses
F M
FM
Chrousos
G C
GC
D000328:Adult; D001127:Arginine Vasopressin / Q000097:blood; D001628:Beverages; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010101:Oxygen Consumption; D010807:Physical Endurance; D011897:Random Allocation; D012420:Running; D014867:Water / Q000008:administration & dosage*
D004040:Dietary Carbohydrates; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D014867:Water; D001127:Arginine Vasopressin; D006854:Hydrocortisone