Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures.
Nerve growth factor (NGF) protein levels were determined in various forebrain regions using a two-site immunoassay following kindling-induced seizures. In the dentate gyrus the NGF content was significantly elevated 7 days after the last seizure (to 152% of control). In the piriform and parietal cortices, maximal increases were seen at 12 h (to 261% of control) and at 24 h (to 169% of control), respectively, and the NGF content was then normalized at 7 days. The increased production of NGF might be a protective response or could be involved in plastic changes underlying kindling epileptogenesis.
Bengzon
J
J
Department of Neurology, University Hospital, Lund, Sweden.
Söderström
S
S
Kokaia
Z
Z
Kokaia
M
M
Ernfors
P
P
Persson
H
H
Ebendal
T
T
Lindvall
O
O
D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000502:physiology*; D016548:Prosencephalon / Q000033:anatomy & histology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism*
D009414:Nerve Growth Factors