Cholecystokinin-induced c-fos expression in the rat brain stem is influenced by vagal nerve integrity.
Exogenous cholecystokinin (CCK) activates brain stem neurons in the area postrema and nucleus of the tractus solitarius, primarily in regions where vagal afferent fibres terminate. The present experiments show that vagal sensory fibres mediate CCK-induced c-fos in brain stem neurons, based on the findings that perivagal capsaicin pre-treatment in seven out of eight cases reduced or ablated c-fos expression in these regions.
Fraser
K A
KA
Department of Medical Physiology, University of Calgary, Alberta, Canada.
Davison
J S
JS
D000818:Animals; D001933:Brain Stem / Q000187:drug effects* / Q000502:physiology; D002211:Capsaicin / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos / Q000187:drug effects*; D007150:Immunohistochemistry; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation / Q000187:drug effects / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology
D016760:Proto-Oncogene Proteins c-fos; D002766:Cholecystokinin; D002211:Capsaicin