Effect of estrogen and progesterone on L-dopa induced dyskinesia in MPTP-treated monkeys.
A group of 4 cynomolgus monkeys was rendered parkinsonian by the toxin MPTP and then treated daily with L-DOPA until all animals developed dyskinesia. At this point, 17 beta-estradiol, 17 alpha-estradiol and progesterone were injected s.c. singly or in combination for 7 days and the treatment with L-DOPA reinstituted. Our results show that the pretreatment with 17 beta-estradiol reduced the dyskinetic effect without altering the therapeutic response to L-DOPA, while 17 alpha-estradiol did not alter the dyskinetic and the antiparkinsonian effect.
Gomez-Mancilla
B
B
Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.
Bédard
P J
PJ
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D004359:Drug Therapy, Combination; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology / Q000517:prevention & control*; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D007980:Levodopa / Q000627:therapeutic use / Q000633:toxicity*; D008252:Macaca fascicularis; D010302:Parkinson Disease, Secondary / Q000188:drug therapy*; D011374:Progesterone / Q000627:therapeutic use*
D007980:Levodopa; D011374:Progesterone; D004958:Estradiol; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine