Cytochrome P450 and the arachidonate cascade.
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.
Capdevila
J H
JH
Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232.
Falck
J R
JR
Estabrook
R W
RW
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D000090762:Cytochrome P-450 CYP2J2; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006900:Hydroxylation; D007668:Kidney / Q000502:physiology; D008563:Membrane Lipids / Q000502:physiology; D008566:Membranes / Q000502:physiology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism
D001095:Arachidonic Acids; D008563:Membrane Lipids; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010105:Oxygenases; C067516:arachidonic acid 18-hydroxylase; D000090762:Cytochrome P-450 CYP2J2