Globus pallidus calcification in Down syndrome with progressive neurologic deficits.
We report a 10-year-old Down syndrome patient who developed dystonia, choreoathetosis, dysarthria, and dysphagia beginning with hemiparesis. Cranial computed tomography disclosed bilateral calcification in the globus pallidus which resembled a sign of premature aging. Conversely, the clinical course and magnetic resonance imaging findings resembled those of Hallervorden-Spatz syndrome.
Okano
S
S
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Takeuchi
Y
Y
Kohmura
E
E
Yoshioka
H
H
Sawada
T
T
D001853:Bone Marrow / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000175:diagnosis* / Q000473:pathology; D005917:Globus Pallidus / Q000473:pathology*; D006429:Hemiplegia / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000473:pathology; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000175:diagnosis* / Q000473:pathology; D012618:Sea-Blue Histiocyte Syndrome / Q000175:diagnosis / Q000473:pathology; D014057:Tomography, X-Ray Computed