title: Adenosine-induced atrioventricular block: a rapid and reliable method to assess surgical and radiofrequency catheter ablation of accessory atrioventricular pathways.
abstract: Adenosine has been shown to inhibit anterograde and retrograde conduction through the atrioventricular (AV) node while having little or no effect on accessory pathway conduction. Its rapid onset of action and short half-life make it particularly suitable for repetitive measurements. In this study, the utility of adenosine was tested in assessing completeness of accessory pathway ablation. Sixteen patients with an accessory pathway were studied (eight surgical ablations, eight catheter ablations with radiofrequency energy). Before ablation, no accessory pathway was sensitive to adenosine. Twelve patients with pre-excitation showed high grade AV node block with maximal pre-excitation on the administration of adenosine during atrial pacing. Four patients with a concealed accessory pathway demonstrated high grade AV block without evidence of latent anterograde accessory pathway conduction. Preablation ventriculoatrial (VA) block was not observed in any of the 16 patients in response to adenosine during ventricular pacing. Immediately after accessory pathway ablation, all patients developed AV and VA block with the administration of adenosine during atrial and ventricular pacing, respectively. These findings were confirmed during follow-up study 1 week later. Atrioventricular block during atrial and ventricular pacing with adenosine affords a reliable and immediate assessment of successful pathway ablation.
authors.affiliation: Department of Medicine, Pediatrics and Surgery, University of Florida, Gainesville.
authors.forename: S
authors.initials: S
authors.lastname: Keim
authors.forename: A B
authors.initials: AB
authors.lastname: Curtis
authors.forename: L
authors.initials: L
authors.lastname: Belardinelli
authors.forename: M L
authors.initials: ML
authors.lastname: Epstein
authors.forename: E D
authors.initials: ED
authors.lastname: Staples
authors.forename: B B
authors.initials: BB
authors.lastname: Lerman
mesh_terms: D000241:Adenosine / Q000009:adverse effects / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000601:surgery; D001283:Atrioventricular Node / Q000187:drug effects*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D004564:Electrocoagulation / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006327:Heart Block / Q000139:chemically induced* / Q000503:physiopathology; D006329:Heart Conduction System / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D000078702:Radiofrequency Therapy; D013617:Tachycardia, Supraventricular / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000241:Adenosine