title: Specificity of screening in United Kingdom trial of early detection of breast cancer.
abstract: OBJECTIVE
  To study the specificity of screening for breast cancer by clinical examination with or without mammography and to estimate the extra breast biopsies resulting from a population screening programme.
  
  
  METHODS
  Non-randomised, population based study.
  
  
  METHODS
  Two screening districts (Edinburgh and Guildford) and four comparison districts (Dundee, Oxford, Southmead, and Stoke).
  
  
  METHODS
  49,956 women aged 45-64 in the screening districts and 127,109 women in the comparison districts.
  
  
  METHODS
  The screening districts offered women annual screening by clinical examination, with mammography in alternate years for seven years.
  
  
  METHODS
  Numbers of true positive, false positive, true negative, and false negative results; specificity and predictive value of screening; numbers of benign and malignant biopsy specimens.
  
  
  RESULTS
  At their first mammographic and clinical screen 94% (30,035/31,997) of women without breast cancer were correctly classified as negative; 6% (1962) were referred for further investigation, but only 321 (1%) required a biopsy to establish that the suspicious lesion was not malignant. At subsequent screens specificity improved to 96%, and only 0.4% of women without cancer received biopsy. After the first screen the ratio of benign to malignant biopsy specimens was the same as that among women in the comparison centres, but because mammographic screening increased the number of women with both malignant and benign disease referred the number of biopsies was increased up to twofold in the years women were offered screening by mammography.
  
  
  CONCLUSIONS
  Our provision of a prompt, highly specialised assessment of women with suspicious lesions at screening may have contributed to the relatively low specificities, while at the same time probably mitigating the adverse effects of low specificity.
mesh_terms: D001706:Biopsy / Q000706:statistics & numerical data; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000517:prevention & control*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008327:Mammography; D008403:Mass Screening; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity