title: Tuberculosis in HIV seropositive individuals--a retrospective analysis.
abstract: A retrospective analysis of all culture-positive cases of Mycobacterium tuberculosis infection in HIV positive individuals, over a 5 year period, revealed 18 cases, drawn from a population of approximately 1500. The prevalence of culture proven M. tuberculosis over the 5 year period was therefore 1.2% and was strongly associated with either a concomitant, or a subsequent, AIDS diagnosis. Sixty-one per cent had pulmonary tuberculosis, 17% had both extra-pulmonary and pulmonary infection and 22% had extra-pulmonary infection alone. Although a wide range of radiological abnormalities was seen, segmental consolidation was the commonest, occurring in 57% of cases. Only 55% of the specimens were positive on initial stains for M. tuberculosis, with a mean duration of 4 weeks to become culture positive, emphasizing that early diagnosis rests on clinical suspicion.
authors.affiliation: Department of Genitourinary Medicine, St Mary's Hospital, Paddington, London, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: Tomlinson
authors.forename: F
authors.initials: F
authors.lastname: Moss
authors.forename: M
authors.initials: M
authors.lastname: McCarty
authors.forename: D
authors.initials: D
authors.lastname: Mitchell
authors.forename: J
authors.initials: J
authors.lastname: Main
authors.forename: J R
authors.initials: JR
authors.lastname: Harris
authors.forename: Q N
authors.initials: QN
authors.lastname: Karim
mesh_terms: D000328:Adult; D002423:Cause of Death; D006679:HIV Seropositivity / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008131:London / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology