[Hereditary angioneurotic edema associated with DIC and treated effectively by nafamostat mesilate].
A 36-year-old woman with disseminated intravascular coagulation syndrome (DIC) was admitted to the Third Department of Internal Medicine of the National Defense Medical College Hospital. Even after she recovered from DIC, she had a low level of C1-inactivator. Her past history, family history and family study revealed that she and her family showed hereditary angioneurotic edema (HANE). There have been no reports of HANE associated with DIC. She had two HANE attacks after discharge. We used nafamostat mesilate, a strong inhibitor of activated first complement component, to treat the attacks. She obtained subjective relief and her serological data were improved. Nafamostat mesilate was considered effective for HANE attack.
Mineshita
M
M
Third Department of Internal Medicine, National Defense Medical College.
Kayashima
S
S
Makishima
M
M
Kimura
F
F
Sasaki
T
T
Takagi
S
S
Matuura
Y
Y
Shimomura
S
S
Yamamoto
K
K
Satou
N
N
D000328:Adult; D000799:Angioedema / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D001550:Benzamidines; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D010375:Pedigree
D001550:Benzamidines; D003174:Complement C1 Inactivator Proteins; D006146:Guanidines; C032855:nafamostat