title: Persistent unilateral tibialis anterior muscle hypertrophy with complex repetitive discharges and myalgia: report of two unique cases and response to botulinum toxin.
abstract: Unilateral enlargement of the tibialis anterior muscle associated with complex repetitive discharges occurred over several months in two patients and was preceded by pain and numbness in the lower leg. Neuroradiologic investigations excluded a compressive radiculopathy, but pharmacologic and neurophysiologic studies suggested a neurogenic basis for the muscle hypertrophy. Botulinum toxin A injection into the hypertrophied muscles led to a decreased muscle volume and cessation of muscle pain.
authors.affiliation: Department of Neurology, University Clinics, Mainz, Germany.
authors.forename: W A
authors.initials: WA
authors.lastname: Nix
authors.forename: I J
authors.initials: IJ
authors.lastname: Butler
authors.forename: S
authors.initials: S
authors.lastname: Roontga
authors.forename: L
authors.initials: L
authors.lastname: Gutmann
authors.forename: H C
authors.initials: HC
authors.lastname: Hopf
mesh_terms: D000328:Adult; D001905:Botulinum Toxins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D006984:Hypertrophy; D007273:Injections, Intramuscular; D007866:Leg; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009135:Muscular Diseases / Q000188:drug therapy / Q000473:pathology*
chemical_list: D001905:Botulinum Toxins