Intratumor treatment of C3H mouse mammary carcinoma with 5-fluorouracil adsorbed on activated charcoal particles.
A dosage form comprising 5-fluorouracil (5-FU, 25 mg/ml) adsorbed on a suspension of micronized charcoal (100 mg/ml) 2-5 microns in diameter, adsorbing 5-FU in aqueous solution was studied for intratumor treatment of mammary carcinoma in animal experiments. An in vitro desorption method is described to determine the amount of 5-FU adsorbed on activated charcoal particles which would be released once the drug concentration decreased around the charcoal. In vivo results indicate that an intratumor injection of 5-FU adsorbed on activated charcoal particles is a highly effective method for achieving tumor regression without increasing toxicity.
Bonhomme
L
L
Laboratoire de Pharmacie, Hôpital Paul Brousse, Villejuif, France.
Mathieu
M C
MC
Amdidouche
D
D
Faure
E
E
Guisteau
D
D
Fredj
G
G
Naveau
S
S
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000327:Adsorption; D000818:Animals; D002606:Charcoal; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D013535:Suspensions
D013535:Suspensions; D002606:Charcoal; D005472:Fluorouracil