title: The management of renal transplant artery stenosis in children by percutaneous transluminal angioplasty.
abstract: Between 1967 and 1989 in this unit 262 children (age at transplantation 9 months to 17 years, mean 9.6 years) had 345 renal transplants performed. Transplant artery stenosis (TAS) was found in 30 (8.7%) as demonstrated by arteriography, performed only when there was unexplained deterioration in transplant function, hypertension that was difficult to control, or in the presence of a vascular bruit. All patients with TAS except one had received a cadaveric allograft. From 1980 onward, percutaneous transluminal angioplasty (PTA) has been available for TAS, and this was attempted on 21 occasions in 16 patients. Nine patients demonstrated angiographic improvement following the procedure, and 7 showed immediate clinical improvement. On one occasion angioplasty precipitated graft loss. Five patients underwent planned corrective surgery, 4 after unsuccessful angioplasties. Our experience suggests that PTA should be the first method of intervention for TAS. Moderate success, both in angiographic and clinical terms, can be achieved, negating the need for surgery, while failure of PTA does not preclude surgical attempts at correction.
authors.affiliation: Evelina Children's Hospital, London, United Kingdom.
authors.forename: N D
authors.initials: ND
authors.lastname: McMullin
authors.forename: J F
authors.initials: JF
authors.lastname: Reidy
authors.forename: C G
authors.initials: CG
authors.lastname: Koffman
authors.forename: S P
authors.initials: SP
authors.lastname: Rigden
authors.forename: G
authors.initials: G
authors.lastname: Haycock
authors.forename: C
authors.initials: C
authors.lastname: Chantler
authors.forename: M
authors.initials: M
authors.lastname: Bewick
mesh_terms: D000293:Adolescent; D000792:Angiography; D000800:Angioplasty, Balloon; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006084:Graft Rejection; D006801:Humans; D006978:Hypertension, Renovascular / Q000188:drug therapy; D007223:Infant; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D009392:Nephrectomy; D012078:Renal Artery Obstruction / Q000209:etiology / Q000628:therapy*; D014184:Transplantation, Homologous
chemical_list: D000959:Antihypertensive Agents