title: The hypertensinogenic activity of 18,19-dihydroxycorticosterone in adrenalectomized rats.
abstract: Adrenalectomized, spontaneously hypertensive rats (SHR) were used to test the hypertensinogenic property of recently synthesized 18,19-dihydroxycorticosterone (18,19-Di-OH-B). The steroid was given via Alzet miniosmotic pump, with and without aldosterone. Neither 18,19-Di-OH-B (5 micrograms) nor aldosterone (5 micrograms) increased blood pressure in SHR when given alone; when administered together they resulted in a significant rise in blood pressure. Results indicate a high probability that certain mineralocorticoids, which are inactive by themselves, might play a role in the etiology of hypertension when acting together under physiological conditions.
authors.affiliation: Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Fragman
authors.forename: M
authors.initials: M
authors.lastname: Harnik
authors.forename: E
authors.initials: E
authors.lastname: Peleg
authors.forename: N
authors.initials: N
authors.lastname: Zamir
authors.forename: T
authors.initials: T
authors.lastname: Rosenthal
mesh_terms: D015069:18-Hydroxycorticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000311:Adrenal Glands / Q000503:physiopathology*; D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood
chemical_list: D004338:Drug Combinations; C051957:18,19-dihydroxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D012083:Renin