title: Direct thrombosis of aneurysms with cellulose acetate polymer. Part II: Preliminary clinical experience.
abstract: The authors report the treatment of seven intracranial aneurysms in six patients with direct infusion of cellulose acetate polymer solution, a new liquid thrombotic material. These aneurysms were considered inoperable because of their size or location, or because of the patient's neurological condition. This material avoids the difficulties associated with balloon occlusion, and completely fills even irregularly shaped aneurysms. Cellulose acetate polymer solution hardens in about 5 minutes and remains solid once inside the aneurysm. Because this technique is less invasive than surgery, it can be used for high-risk patients in the acute stage of subarachnoid hemorrhage. Transient motor aphasia occurred in one patient. A small residual neck, which caused rebleeding 3 months after the treatment, remained in another patient. This article describes the new material, the procedure for direct thrombosis, and preliminary clinical results.
authors.affiliation: Department of Neurological Surgery, Okayama University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kinugasa
authors.forename: S
authors.initials: S
authors.lastname: Mandai
authors.forename: Y
authors.initials: Y
authors.lastname: Terai
authors.forename: I
authors.initials: I
authors.lastname: Kamata
authors.forename: K
authors.initials: K
authors.lastname: Sugiu
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
authors.forename: A
authors.initials: A
authors.lastname: Nishimoto
mesh_terms: D000328:Adult; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011108:Polymers / Q000627:therapeutic use*; D012008:Recurrence; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000150:complications
chemical_list: D011108:Polymers; C005062:acetylcellulose; D002482:Cellulose