title: The effect of dihydrotestosterone on the estrogen-induced cytodifferentiation of the chick oviduct.
abstract: The androgenic effects on the estrogen-induced cytodifferentiation of the chick oviduct epithelium were investigated. Dihydrotestosterone was shown to have an effect on the organization of stromal cells. Since these cells contained androgen receptor (AR), it is reasonable to assume an involvement of androgens in the differentiation and functioning of these cells through a direct action. Immunohistochemical analysis revealed a wide distribution of AR. AR was shown to be expressed in both the endothelial and smooth muscle cells of blood vessels. In the immature oviduct AR was located in the epithelial, mesenchymal and mesothelial cells. In the differentiating oviduct, whether induced by exogenous estrogen or normally by endogenous hormones, AR was also expressed by the tubular gland cells. Dihydrotestosterone alone had no effect on the morphology of the immature oviduct, suggesting the involvement of the determinants of differentiation in the action of androgen together with estrogen.
authors.affiliation: Department of Biomedical Sciences, University of Tampere, Finland.
authors.forename: T K
authors.initials: TK
authors.lastname: Joensuu
authors.forename: M K
authors.initials: MK
authors.lastname: Bläuer
authors.forename: T
authors.initials: T
authors.lastname: Sannisto
authors.forename: P J
authors.initials: PJ
authors.lastname: Tuohimaa
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002645:Chickens; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D004054:Diethylstilbestrol / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D010057:Oviducts / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D011374:Progesterone / Q000494:pharmacology*; D011467:Prostate / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011944:Receptors, Androgen / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D012867:Skin / Q000166:cytology / Q000187:drug effects; D012879:Skin Physiological Phenomena
chemical_list: D000726:Androgen Antagonists; D011944:Receptors, Androgen; D013196:Dihydrotestosterone; D011374:Progesterone; D017373:Cyproterone Acetate; D004958:Estradiol; D004054:Diethylstilbestrol; D003534:Cyproterone