Amlodipine in post-infarction angina.
Once-daily administration of amlodipine is a highly effective treatment for patients with angina pectoris. This study has confirmed its benefit in a relatively large subgroup of patients with post-myocardial infarction angina. Amlodipine reduced the number of angina attacks and nitroglycerin consumption and substantially improved the ability of the patient to perform physical exercise. The circadian pattern of angina attacks was markedly attenuated by amlodipine with patients reporting fewer attacks during the mid-morning peak that was clearly evident at baseline. The advantage of once-daily dosing, together with the excellent control of angina achieved in post-infarction patients, make amlodipine a good choice for therapy.
Taylor
S H
SH
University Department of Cardiovascular Studies, General Infirmary, Leeds, UK.
D017311:Amlodipine; D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D017311:Amlodipine; D009543:Nifedipine