[Preoperative administration of 5-FU emulsion for lymph nodes metastasis of pancreatic carcinoma].
5-FU oil emulsion (n = 5) or 5-FU dry syrup (n = 4), at a daily dose of 332mg for 7 days, was administered preoperatively to patient with periampullary carcinoma to evaluate the uptake of 5-FU to regional lymph nodes. In the group given 5-FU oil emulsion, the mean concentration of 5-FU was 293 +/- 97 ng/ml (mean +/- S.E.D), and that of the group given dry syrup was 72 +/- 20 ng/ml. Although no statistically significant difference was found, 5-FU seemed to reach the regional lymph nodes as an emulsion rather than as an aqueous solution. Preoperative administration of 5-FU emulsion might have some favorable effect on lymph node metastasis and lymph invasion of pancreatic carcinoma.
Kakizaki
K
K
Dept. of Surgery, Sendai National Hospital.
Yamada
Y
Y
Yamauchi
H
H
D000284:Administration, Oral; D002277:Carcinoma / Q000473:pathology*; D004655:Emulsions; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism; D008207:Lymphatic Metastasis; D010190:Pancreatic Neoplasms / Q000473:pathology*; D011300:Preoperative Care
D004655:Emulsions; D005472:Fluorouracil