Micronucleus formation in peripheral-blood lymphocytes from smokers and the influence of alcohol- and tea-drinking habits.
In recent years, studies on the genotoxic effects of smoking and its modifying factors have been widely followed with interest. In this report, frequencies of micronuclei (MNF) in peripheral-blood lymphocytes in 220 healthy smokers have been detected by the micronucleus test by finger-skin puncture, which needs only 1 to 2 drops of peripheral blood. On the basis of analysis of matched-pair data, the modifying effects of alcohol and tea are discussed. Our results show that (I) smoking significantly increases MNF in lymphocytes as compared with healthy non-smokers (p less than 0.01); (2) alcohol significantly increases MNF in smokers (p less than 0.01); (3) tea decreases MNF induced by smoking (p less than 0.01). Therefore, the anti-carcinogenic role of tea merits further study.
Xue
K X
KX
Cytogenetic Research Laboratory, Jiangsu Institute of Cancer Research, Nanjing, People's Republic of China.
Wang
S
S
Ma
G J
GJ
Zhou
P
P
Wu
P Q
PQ
Zhang
R F
RF
Xu
Z
Z
Chen
W S
WS
Wang
Y Q
YQ
D000328:Adult; D000368:Aged; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D015162:Micronucleus Tests; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control; D012907:Smoking / Q000473:pathology*; D013662:Tea
D013662:Tea; D000431:Ethanol