Immune response to the nominal phosphoprotein of rabies virus.
The immune response to the nominal phosphoprotein (NS protein) of rabies virus was investigated with the use of a vaccinia recombinant virus that expressed the NS protein of a fixed rabies virus strain. Mice of the H-2k haplotype that were injected with either live rabies virus or the vaccinia recombinant virus developed a strong cytolytic T-cell response specific for the NS protein. This response was under immune response (Ir) gene control. The NS protein as presented by the vaccinia recombinant virus was a poor inducer of rabies virus-specific T-helper (Th) cells and B cells in the H-2k background. Furthermore, mice of the H-2k haplotype could not be protected by vaccination with the vaccinia recombinant virus expressing the NS protein, although protection in outbred mice was partial and incomplete. These data indicate that cytolytic T cells to the NS protein of rabies virus are insufficient to protect mice against a challenge with rabies virus.
Larson
J K
JK
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104-4268.
Wunner
W H
WH
Ertl
H C
HC
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology / Q000382:microbiology; D001483:Base Sequence; D002213:Capsid / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D006367:HeLa Cells; D006801:Humans; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D011994:Recombinant Proteins / Q000378:metabolism; D013045:Species Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000382:microbiology; D014616:Vaccinia virus / Q000235:genetics; D014758:Viral Core Proteins / Q000276:immunology*; D017361:Viral Nonstructural Proteins
D000914:Antibodies, Viral; D010750:Phosphoproteins; D011994:Recombinant Proteins; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins