[Histological evaluation of intra-arterial infusion and systemic chemotherapy of pancreatic carcinomas].
Histological analyses of 16 autopsies of pancreatic carcinoma [9 cases after intra-arterial infusion chemotherapy (IAC), and 7 cases of systemic chemotherapy (SC)] were performed. Histological effects of chemotherapy (Shimosato) were seen in 15 cases, but less than 5 Grade II a. cases of IAC and 4 cases of SC showed Grade IIa, 3 cases of IAC and 3 cases of SC showed Grade I. The ratio of Grade IIa was almost the same in IAC and SC. But histologically, anaplastic change, sarcomatous change and Bizarre cells, immunohistologically positive to anti-EMA and Vimentin antibody, were dominant in IAC. And clinically, serum tumor markers (CEA, CA19-9) were fewer in almost all the cases in IAC. These results may suggest that the anti-tumor effect of IAC was greater than the histological appearance.
Kunimura
T
T
1st Dept. of Pathology, Showa University School of Medicine, Tokyo, Japan.
Morohoshi
T
T
Sato
M
M
Kikuchi
H
H
Kanda
M
M
Taguchi
S
S
Hatta
Y
Y
Miura
K
K
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005641:Tegafur / Q000008:administration & dosage
D005641:Tegafur; D016685:Mitomycin; D005472:Fluorouracil