title: The Gubbio data. Epidemiology and pathophysiology. Gubbio Study Research Group.
abstract: The relation between the maximal velocity of red blood cell sodium-lithium countertransport and blood pressure/hypertension has been studied in 2,748 men and women aged 25-74 years who participated in the 1983-85 baseline examination of the Gubbio Population Study, an epidemiologic investigation performed in a hill town of north central Italy. Men had a higher sodium-lithium countertransport velocity than women at all ages, and, in both sexes, a higher velocity was observed at successive ages. Hypertensives of both sexes had a higher sodium-lithium countertransport velocity than normotensive individuals, the difference remaining significant after control for age, body mass index and plasma uric acid concentration. Individuals with high sodium-lithium countertransport velocity had significantly greater prevalence of hypertension in both sexes. The data show the existence of a cross-sectional association between sodium-lithium countertransport velocity and hypertension in general population. Prospective study of the Gubbio population is now in progress to investigate the relation between baseline sodium-lithium countertransport velocity, its change over the years and the incidence of hypertension.
authors.affiliation: Merck Sharp & Dohme, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Laurenzi
authors.forename: M
authors.initials: M
authors.lastname: Cirillo
authors.forename: M
authors.initials: M
authors.lastname: Trevisan
mesh_terms: D000328:Adult; D000368:Aged; D001693:Biological Transport, Active; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D007558:Italy / Q000453:epidemiology; D007700:Kinetics; D008094:Lithium / Q000097:blood; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood
chemical_list: D008094:Lithium; D012964:Sodium