Racemized D-aspartate in Alzheimer neurofibrillary tangles.
Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo posttranslational modification by racemization to D-aspartate. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a greater number of these racemized D-aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains.
Fisher
G H
GH
Department of Chemistry, University of Miami, Coral Gables, FL 33124.
Payan
I L
IL
Chou
S J
SJ
Man
E H
EH
Cerwinski
S
S
Martin
T
T
Emory
C
C
Frey
W H
WH
D000544:Alzheimer Disease / Q000378:metabolism*; D001224:Aspartic Acid / Q000378:metabolism*; D052160:Benzothiazoles; D002849:Chromatography, Gas; D005456:Fluorescent Dyes; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D013237:Stereoisomerism; D013844:Thiazoles
D052160:Benzothiazoles; D005456:Fluorescent Dyes; D009419:Nerve Tissue Proteins; D013844:Thiazoles; C009462:thioflavin T; D001224:Aspartic Acid