I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse.
Analysis of TCR beta-chain V region (V beta) frequency among NOD lymphocytes reveals a profound depletion of V beta 3+ T cells, and a recent study has linked this phenomenon to the Mtv-3 insertion on chromosome 11. When the V beta 17a gene segment is introduced into mice with an nonobese diabetic mouse background, T cells bearing the TCR encoded by this gene segment are also dramatically reduced in frequency. Deletion of V beta 17a+ T cells segregates with deletion of T cells bearing V beta 3 and occurs in the absence of I-E, which had been shown in previous studies to be a major deleting element for V beta 17a+ thymocytes.
McDuffie
M
M
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262.
Schweiger
D
D
Reitz
B
B
Ostrowska
A
A
Knight
A M
AM
Dyson
P J
PJ
D000818:Animals; D002872:Chromosome Deletion; D000949:Histocompatibility Antigens Class II / Q000502:physiology*; D006825:Hybridomas / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis; D051379:Mice; D016688:Mice, Inbred NOD; D016747:Minor Lymphocyte Stimulatory Antigens / Q000032:analysis; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000032:analysis* / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007376:Interleukin-2; D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta