Dexamethasone induces a transient relative cardiomegaly in neonatal rats.
Effects of s.c. administration of dexamethasone (1-25 micrograms/rat pup/d) during the first 5 d postpartum on survival rates, body weight, heart weight, heart-to-body weight ratios, and heart dimensions were determined. Dexamethasone decreased survival, body weight, and heart weight, but increased heart-to-body weight ratios and myocardial percentage of dry weight (0.44 to 0.52-1.06 and 20 to 23%, respectively; p less than 0.05) by 7 d postpartum. By 21 d postpartum, differences in absolute body weight and heart weight between control and experimental animals were reduced; however, myocardial percentage of dry weight and heart-to-body weight ratios were indistinguishable. Microscopic analysis of 7-d-old hearts disclosed that interventricular septum, left ventricular free wall thicknesses, and left ventricle chamber diameter were reduced (0.93 to 0.76-0.85 mm, 1.19-1.34 to 0.92-1.07 mm, and 1.35-1.40 to 0.89-1.23 mm, respectively; p less than 0.05), whereas right ventricular free wall thickness was unaffected and right ventricle chamber diameter was increased (0.29-0.31 to 0.42-0.46 mm) by dexamethasone. Thus, dexamethasone reduced survival and retarded growth of neonatal rats. Retardation of heart growth was less severe, producing a transient relative cardiomegaly characterized by 1) increased myocardial percentage of dry weight, 2) increased left ventricular free wall-to-chamber ratio, and 3) retention of absolute right ventricular free wall thickness. This relative cardiomegaly appeared to be resolved by 21 d postpartum, as reflected in myocardial percentage of dry weight and heart-to-body weight ratios.(ABSTRACT TRUNCATED AT 250 WORDS)
Sicard
R E
RE
Department of Pediatrics, Rhode Island Hospital, Providence 02903.
Werner
J C
JC
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D006332:Cardiomegaly / Q000139:chemically induced* / Q000473:pathology; D003907:Dexamethasone / Q000633:toxicity*; D004195:Disease Models, Animal; D006130:Growth Disorders / Q000139:chemically induced / Q000473:pathology; D006321:Heart / Q000187:drug effects / Q000254:growth & development; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D003907:Dexamethasone