title: Results of a 4-week head-down tilt with and without LBNP countermeasure: I. Volume regulating hormones.
abstract: The volume regulating hormones were studied during a 4-week head-down tilt (CNES HDT) in five subjects with and without (controls) lower body negative pressure (LBNP). LBNP was applied 3 times a day for 3 weeks, 4 times a day for 4 d, and 6 times a day for 3 d the last week. In both groups we observed a significant decrease in body weight (3% in controls, 0.8% in LBNP), a significant increase in plasma renin activity and aldosterone (with an amplification of their rhythms), and a significant decrease in norepinephrine with no difference between the two groups. The only major hormonal difference was observed for atrial natriuretic factor (ANF), which decreased significantly in the control group and increased in the LBNP group. These results are compared with the improvement in orthostatic tolerance (OT) after HDT in the LBNP group in the same protocol (17). We conclude that many factors could be involved in the improvement of OT. The results suggest that better conservation of plasma volume in the LBNP group might have prevented a decrease in ANF. Whether ANF plays a role in the regulation of baroreceptor reflex with an improvement in OT is currently unknown.
authors.affiliation: Laboratoire de Physiologie de l'Environment, Faculté de Médecine Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Gharib
authors.forename: A
authors.initials: A
authors.lastname: Maillet
authors.forename: G
authors.initials: G
authors.lastname: Gauquelin
authors.forename: A M
authors.initials: AM
authors.lastname: Allevard
authors.forename: A
authors.initials: A
authors.lastname: Güell
authors.forename: R
authors.initials: R
authors.lastname: Cartier
authors.forename: P
authors.initials: P
authors.lastname: Arbeille
mesh_terms: D000450:Aldosterone / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D001810:Blood Volume / Q000502:physiology; D001826:Body Fluids / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D015444:Exercise; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology; D008150:Lower Body Negative Pressure; D011187:Posture; D011311:Pressoreceptors / Q000502:physiology; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood; D013026:Space Flight
chemical_list: D002395:Catecholamines; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D012083:Renin