title: Production of interleukin-1-like cytokine by cultured rat glomerular macrophages.
abstract: Resident glomerular macrophages from normal rats were isolated and grown through long-term cultures in order to obtain confluent cell monolayers. These cells have a secretory function as revealed by the production of a cytokine with a molecular weight similar to interleukin-1 (IL-1). The demonstration that rat glomerular macrophages secrete an IL-1-like cytokine emphasizes the role of these cells in a number of glomerular secretory functions, including some which have been commonly attributed only to mesangial contractile cells.
authors.affiliation: Department of Pathology, Hospital Ramon y Cajal Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Mampaso
authors.forename: T
authors.initials: T
authors.lastname: Bricio
authors.forename: A
authors.initials: A
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Molina
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005920:Glomerular Mesangium / Q000187:drug effects / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis*; D007678:Kidney Glomerulus / Q000166:cytology / Q000276:immunology*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007375:Interleukin-1; D008070:Lipopolysaccharides