title: Polysaccharide encapsulated bacterial infection in sickle cell anemia: a thirty year epidemiologic experience.
abstract: Annual age-specific incidence rates of Streptococcus pneumoniae or Haemophilus influenzae bacterial septicemia in sickle cell anemia (SS) were determined for the years of 1957 through 1989. Forty-nine patients had 64 episodes of septicemia among a population of 786 SS patients observed for 8,138 person-years. Peak frequency of infection occurred between 1968-1971 and 1975-1981 with a conspicuous absence of episodes in 1972, 1973, 1982-1984, and 1986-1987, thus demonstrating cycles of high and low attack rates. The annual age-specific incidence rate of septicemia varied from 64.5 (1965) to 421.1 (1980) per 1,000 person-years for those under 2 years of age and never exceeded 10.2 per 1,000 in those over 4 years of age. Following the introduction of pneumococcal polyvalent vaccine in 1978, incidence of infection decreased in SS children greater than 2 years of age. No modification of the risk of infection was observed in immunized children less than 2 years of age. During these three decades, there has been a ten-fold increase in the number of SS adults over 20 years of age. The relative risk of chronic sickle complications comparing the survivors of septicemia to the non-infected patients was: subsequent death 1.76, retinopathy 4.06, avascular necrosis 1.95, symptomatic cholelithiasis 1.33, stroke 1.30, and priapism 1.26. These data suggest that prognosis for lifetime severe SS is initially manifested as an increased risk of septicemia during childhood.
authors.affiliation: Department of Pediatrics, Division of Hematology-Oncology, University of Southern California, School of Medicine, Los Angeles.
authors.forename: W Y
authors.initials: WY
authors.lastname: Wong
authors.forename: D R
authors.initials: DR
authors.lastname: Powars
authors.forename: L
authors.initials: L
authors.lastname: Chan
authors.forename: A
authors.initials: A
authors.lastname: Hiti
authors.forename: C
authors.initials: C
authors.lastname: Johnson
authors.forename: G
authors.initials: G
authors.lastname: Overturf
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D004812:Epidemiologic Methods; D006192:Haemophilus Infections / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D006193:Haemophilus influenzae; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015993:Life Tables; D011008:Pneumococcal Infections / Q000150:complications* / Q000453:epidemiology / Q000401:mortality; D012307:Risk Factors; D013296:Streptococcus pneumoniae; D016019:Survival Analysis