Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes.
The phenolic diterpene carnosic acid appears to be the main substance for general oxidation leading to artifacts with gamma- or delta-lactone structure in extracts of Rosmarinus officinalis and Salvia officinalis. Until now it was only possible to prepare carnosic acid by hydrogenolysis of carnosol. A semipreparative HPLC method has been developed isolating carnosic acid among other phenolic diterpenes. The separated substances were identified by 13C-nuclear magnetic resonance (NMR), 1H-NMR, mass and IR spectroscopy. Conversion of carnosic acid and carnosol to other phenolic diterpenes was investigated by HPLC.
Schwarz
K
K
Institute of Food Science, University of Hannover, Federal Republic of Germany.
Ternes
W
W
D045784:Abietanes; D000975:Antioxidants / Q000032:analysis* / Q000737:chemistry; D002336:Carnosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010616:Phenanthrenes / Q000737:chemistry; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification*; D013055:Spectrophotometry, Infrared
D045784:Abietanes; D000975:Antioxidants; D004224:Diterpenes; D010616:Phenanthrenes; D010936:Plant Extracts; C068623:carnosol; D002336:Carnosine; C018381:salvin