title: Ten year follow-up study of women presenting to a genitourinary medicine clinic with anogenital warts.
abstract: One hundred heterosexual women presenting at our clinic in 1979 with anogenital warts, were reviewed 10 years later. Median duration of warts following initial clinic attendance was 2 months (range 0-120 months). In 1979 cervical PAP smear results were available for 76 patients; cervical intraepithelial neoplasia (CIN) was seen in 15/76 (19.7%) women; 3 (4%) women had low grade CIN, 12 (15.7%) women had high grade CIN. Nineteen women had had treatment for CIN between 1979 and 1989, 7 laser ablation, 9 cone biopsy, 2 laser ablation and cone biopsy, and one woman laser ablation, cauterization and cone biopsy. At 10-year follow-up in 1989 4/100 women had anogenital warts, 12/100 women had cytological evidence of CIN (7 low grade, 5 high grade), and 37/100 women had CIN detected on colposcopic biopsy (31 low grade, 6 high grade). No women developed invasive cervical carcinoma during the study period. CIN lesions, detected in 1979, regressed without any treatment in 2 women. Colposcopic biopsy was 3.1 times more sensitive than single cervical PAP smear at detecting CIN (4.4 times as sensitive in detecting low grade CIN; 1.2 times as sensitive in detecting high grade CIN). In 1989 CIN was detected in 7/19 (36.8%) of women who had undergone cervical treatment between 1979 and 1989, and in 35/81 (43.2%) of women having no cervical treatment within this period (chi squared P greater than 0.5). These findings suggest that cervical laser ablative therapy and cone biopsy do not in the long term influence the natural history of cervical human papilloma virus-associated disease (CIN) in women with anogenital warts.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast, Northern Ireland.
authors.forename: J
authors.initials: J
authors.lastname: Handley
authors.forename: H
authors.initials: H
authors.lastname: Lawther
authors.forename: T
authors.initials: T
authors.lastname: Horner
authors.forename: R
authors.initials: R
authors.lastname: Maw
authors.forename: W
authors.initials: W
authors.lastname: Dinsmore
mesh_terms: D000293:Adolescent; D000328:Adult; D001005:Anus Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D001706:Biopsy / Q000592:standards; D003127:Colposcopy / Q000592:standards; D003218:Condylomata Acuminata / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D009660:Northern Ireland / Q000453:epidemiology; D010044:Outpatient Clinics, Hospital; D065006:Papanicolaou Test; D012307:Risk Factors; D012680:Sensitivity and Specificity; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D014626:Vaginal Smears / Q000592:standards