title: Cellular infiltration of the vitreous in a patient with X-linked immunodeficiency with increased IgM.
abstract: We studied visual impairment caused by benign lymphoid infiltration of the vitreous bilaterally, as a complication of a primary immunodeficiency, X-linked immunodeficiency with increased IgM in an 8-year-old boy. Immunophenotyping of a vitreous aspirate showed a mixed cell population, including lymphocytes (T helper, suppressor-cytotoxic T cells, and B cells) and macrophages. Cultures of the vitreous were negative for bacterial or fungal pathogens. The vitreous infiltrates have been resistant to treatment with corticosteroids and cytotoxic agents.
authors.affiliation: Department of Ophthalmology, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: K J
authors.initials: KJ
authors.lastname: Johns
authors.forename: D S
authors.initials: DS
authors.lastname: Hummell
authors.forename: T L
authors.initials: TL
authors.lastname: McCurley
authors.forename: A R
authors.initials: AR
authors.lastname: Lawton
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics*; D002648:Child; D005128:Eye Diseases / Q000473:pathology; D005654:Fundus Oculi; D008040:Genetic Linkage; D006801:Humans; D006942:Hypergammaglobulinemia / Q000235:genetics* / Q000276:immunology; D007075:Immunoglobulin M; D016131:Lymphocyte Subsets / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008297:Male; D014822:Vitreous Body / Q000473:pathology*; D014960:X Chromosome
chemical_list: D007075:Immunoglobulin M