[Changes in systemic fibrinolysis and blood coagulation parameters in local thrombolysis with tissue plasminogen activator (rt-PA)].
During the local fibrinolysis with rt-PA (2.5 mg/h) systemic plasminogen and alpha 2-antiplasmin activities slightly decrease, but the fibrinolytic system is compensated during the whole treatment. The d-dimer plasma levels increase dependently on the mass of thrombus. Despite the administration of high doses of heparin during the fibrinolysis thrombin is formed, measured as thrombin-antithrombin III complex (TAT).
Klein
P
P
Aggertalklinik Engelskirchen, Universität Bonn.
Roth
F J
FJ
Rieger
H
H
Popov-Cenic
S
S
D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D001807:Blood Vessel Prosthesis; D004305:Dose-Response Relationship, Drug; D005263:Femoral Artery / Q000187:drug effects* / Q000601:surgery; D005342:Fibrinolysis / Q000187:drug effects* / Q000502:physiology; D006083:Graft Occlusion, Vascular / Q000097:blood / Q000188:drug therapy*; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007261:Infusions, Intra-Arterial; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator
Anderungen systemischer Fibrinolyse- und Gerinnungsparameter während der lokalen Lyse mit Tissue Plasminogen Activator (rt-PA).