Epithelioid sarcoma. Flow cytometric study of DNA content and regional DNA heterogeneity.
The DNA content and regional DNA heterogeneity in correlation with clinicopathologic parameters and patient survival were investigated in epithelioid sarcoma. Such neoplasms preponderantly manifest diploid DNA content and a remarkably stable intratumoral and intertumoral DNA content. Small tumor size (less than 5.0 cm) and low S-phase fraction (less than 5%) were significant prognostic factors in this study. Ploidy status, mitotic rate, age, and postsurgical treatment were not significantly correlated with survival.
el-Naggar
A K
AK
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Garcia
G M
GM
D000293:Adolescent; D000328:Adult; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D014644:Genetic Variation / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D012509:Sarcoma / Q000737:chemistry* / Q000235:genetics / Q000401:mortality; D012983:Soft Tissue Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000401:mortality
D004273:DNA, Neoplasm