Antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, Thaliblastine, on two human glioma cell lines.
The antiproliferative activity of the non-myelotoxic antitumour agent of plant origin, Thaliblastine, on two human glioma cell lines is described. Thaliblastine was added once one day following start of culture; proliferation was monitored over 7 days. The antiproliferative activity of Thaliblastine was strongly dependent on concentration and time of incubation. The ID50 of Thaliblastine in T406 and GW27 glioma lines was 5.1 micrograms/ml and 8.2 micrograms/ml (7.0 microM and 11.2 microM), respectively.
Todorov
D K
DK
National Oncological Center, Sofia, Bulgaria.
Zeller
W J
WJ
D001060:Aporphines / Q000008:administration & dosage / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D014407:Tumor Cells, Cultured / Q000187:drug effects
D001060:Aporphines