title: Why do hemophiliacs bleed?
abstract: A revised hypothesis of coagulation integrates all the factors known to be involved into a single pathway that is initiated by factor VIIa/tissue factor and in which "contact" factors are not required. A key point is that the initial hemostatic response must be "consolidated" by the progressive local generation of factor Xa and thrombin.
authors.affiliation: Washington University School of Medicine, St. Louis.
authors.forename: G J
authors.initials: GJ
authors.lastname: Broze
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D008954:Models, Biological; D013925:Thromboplastin / Q000037:antagonists & inhibitors / Q000502:physiology
chemical_list: D013925:Thromboplastin