title: Sequence analysis of two exons from the murine dystrophin locus.
abstract: We have isolated two genomic clones from the murine dystrophin locus, containing single exons encoding protein sequence from the putative actin-binding domain of the amino-terminus and the terminal portion of the triple helical domain. Using interspecific backcross progeny mice, both clones were shown to be X-linked. Sequence analysis indicated that the amino-terminal clone contains a 173 bp exon exhibiting 90% nucleotide sequence identity to human dystrophin exon 6, whilst the C-terminal clone contains a 61 bp exon with 93% nucleotide sequence identity to the human cDNA sequence.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, Norfolk Place, London, UK.
authors.forename: M K
authors.initials: MK
authors.lastname: Maconochie
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
authors.forename: A J
authors.initials: AJ
authors.lastname: Greenfield
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D016189:Dystrophin / Q000235:genetics*; D005091:Exons; D051379:Mice; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D016415:Sequence Alignment
chemical_list: D016189:Dystrophin; D004247:DNA