title: Comparative evaluation of the elasticity and flexibility of bioimpregnated knitted grafts.
abstract: Longitudinal elasticities of whole human blood clot, whole canine blood clot, Factor XIII cross-linked fibrin, glutaraldehyde-fixed human albumin, and formaldehyde-fixed collagen, gelatin and collagen/gelatin were determined and normalized to human whole blood clot. Matrices of a knitted Dacron graft were then impregnated with albumin, collagen, and collagen/gelatin and their longitudinal elasticities were determined and normalized to a preclotted graft. Comparisons were also made for the longitudinal elasticities of a virgin graft, a manipulated control for a preclotted graft, and a manipulated control for the matrix-impregnated grafts. Flexibilities were then calculated based on the weights and elasticities of these grafts and normalized to the flexibility of the preclotted graft. Fibrin had twice and 39 times more longitudinal elasticity than human blood clot and collagen, respectively. The preclotted graft has longitudinal elastic properties similar to a virgin graft, and is 2.8, 2, and 1.4 times more elastic than the albumin, collagen and collagen/gelatin grafts, respectively. The preclotted graft was 2.5, 2, and 1.4 times more flexible than the albumin, collagen and collagen/gelatin grafts, respectively.
authors.affiliation: Hope Heart Institute, Providence Medical Center, Seattle, Washington 98122.
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: A
authors.initials: A
authors.lastname: Kaplan
authors.forename: L R
authors.initials: LR
authors.lastname: Sauvage
authors.forename: H D
authors.initials: HD
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Kaplan
authors.forename: Y
authors.initials: Y
authors.lastname: Usui
authors.forename: M W
authors.initials: MW
authors.lastname: Walker
mesh_terms: D000418:Albumins; D000818:Animals; D001696:Biomechanical Phenomena; D001705:Bioprosthesis; D001777:Blood Coagulation; D001807:Blood Vessel Prosthesis; D003094:Collagen; D004285:Dogs; D004548:Elasticity; D005780:Gelatin; D006801:Humans; D008955:Models, Cardiovascular; D011093:Polyethylene Terephthalates; D011474:Prosthesis Design
chemical_list: D000418:Albumins; D011093:Polyethylene Terephthalates; D005780:Gelatin; D003094:Collagen