A unique circulating inhibitor with specificity for coagulation factor X.
An 84-year-old woman presented with extensive cutaneous and gastrointestinal bleeding. Initial laboratory studies revealed a prolonged prothrombin time and activated partial thromboplastin time. Further investigations revealed a circulating anticoagulant with specificity for factor X. The patient's hemorrhage resolved with supportive measures only. Approximately 11 months after presentation, the inhibitor disappeared.
Lankiewicz
M W
MW
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2101.
Bell
W R
WR
D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation / Q000502:physiology*; D003937:Diagnosis, Differential; D005171:Factor X Deficiency / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans