Interstitial pneumonitis, pulmonary fibrosis, and chronic graft-versus-host disease.
Pneumonopathies in association with graft-versus-host disease (GVHD) are known, but the evolution of biopsy-proven interstitial pneumonitis (IP) to pulmonary fibrosis as a major pulmonary manifestation in an individual patient with chronic GVHD has not been previously reported. We present a patient with chronic GVHD who developed IP and then pulmonary fibrosis. We suggest that IP with evolution to pulmonary fibrosis was a major pulmonary manifestation of chronic GVHD in this patient.
Kaplan
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Department of Pediatrics, Children's Hospital of Philadelphia.
Pietra
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GG
August
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CS
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008297:Male; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology