The hypertensinogenic activity of 18,19-dihydroxycorticosterone in adrenalectomized rats.
Adrenalectomized, spontaneously hypertensive rats (SHR) were used to test the hypertensinogenic property of recently synthesized 18,19-dihydroxycorticosterone (18,19-Di-OH-B). The steroid was given via Alzet miniosmotic pump, with and without aldosterone. Neither 18,19-Di-OH-B (5 micrograms) nor aldosterone (5 micrograms) increased blood pressure in SHR when given alone; when administered together they resulted in a significant rise in blood pressure. Results indicate a high probability that certain mineralocorticoids, which are inactive by themselves, might play a role in the etiology of hypertension when acting together under physiological conditions.
Fragman
S
S
Chorley Hypertension Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Harnik
M
M
Peleg
E
E
Zamir
N
N
Rosenthal
T
T
D015069:18-Hydroxycorticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000311:Adrenal Glands / Q000503:physiopathology*; D000315:Adrenalectomy; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood
D004338:Drug Combinations; C051957:18,19-dihydroxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D012083:Renin