[The usefulness of determining antigliadin IgA antibodies for the detection and follow-up of adult celiac disease].
Antibodies to gliadin IgA (IgA-AGA) were detected by enzyme-linked-immunosorbent-technique (ELISA) in 30 healthy controls, 20 coeliac patients and 25 patients with non coeliac malabsorption. All the controls had levels of IgA-AGA in the normal range (25AV). Three of the 25 patients with non coeliac malabsorption presented high titres of IgA-AGA. Thirty six determinations of IgA-AGA were made on the coeliac patients. All but one of the determinations made during the symptomatic phase of the disease were 25AV. The highest titres corresponded either to untreated patients or patients with complications (cirrhosis, lymphoma). In our study the sensitivity and the specificity of the test for symptomatic patients were 94.4% and 94.5% respectively.
Iglesias Picazo
M R
MR
Hospital de La Princesa, Servicio de Medicina-Digestivo, Universidad Autónoma de Madrid.
Jiménez Alonso
I
I
Melón Rey
M A
MA
Rodríguez Gómez
S
S
Sánchez Alonso
J
J
Villanueva Sánchez
C
C
Pajares García
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002446:Celiac Disease / Q000175:diagnosis*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D007070:Immunoglobulin A; D005903:Gliadin
Utilidad de la determinación de los anticuerpos antigliadina IgA séricos para la detección y seguimiento de la enfermedad celiaca del adulto.