title: Hormonal treatment of unresectable pancreatic cancer with LHRH analogue (goserelin).
abstract: Recently non-controlled clinical trials reported encouraging results using a suppressive endocrine treatment in patients with unresectable pancreatic cancer. In this study 15 patients were given an LHRH analogue every 4 weeks (goserelin 3.6 mg), while 18 patients with advanced stage pancreatic carcinoma were given only symptomatic therapy. All patients treated with goserelin had sexual hormone suppression. Follow-up included abdominal ultrasound or computed tomography scan every 3 months; Ca 19-9 assay and routine laboratory blood tests were performed every month. No partial or complete response, no performance status or Ca 19-9 level changes were found. No significant difference in survival was seen in the two groups of patients. This study suggests that goserelin is unlikely to have a major influence on the survival of patients with advanced pancreatic carcinoma and casts further doubt upon the hormone-dependence of this neoplasm.
authors.affiliation: Clinical Chirurgica I, Cattedra di Patologia Speciale Chirurgica, University of Padua, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Sperti
authors.forename: C
authors.initials: C
authors.lastname: Pasquali
authors.forename: S
authors.initials: S
authors.lastname: Catalini
authors.forename: F
authors.initials: F
authors.lastname: Cappellazzo
authors.forename: B
authors.initials: B
authors.lastname: Bonadimani
authors.forename: C
authors.initials: C
authors.lastname: Militello
authors.forename: S
authors.initials: S
authors.lastname: Pedrazzoli
mesh_terms: D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D002064:Buserelin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood; D017273:Goserelin; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D011446:Prospective Studies; D016019:Survival Analysis
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D012739:Gonadal Steroid Hormones; D006065:Gonadotropins, Pituitary; D017273:Goserelin; D002064:Buserelin