CD23 expression in aged rats.
CD23 is considered as an activation marker. Its expression on lymphocytes was studied during aging by using 1- to 142-week-old rats. Before analysis, all animals were injected with monoclonal IgE, in order to detect their full expression of CD23 molecules on their lymphocyte surface membranes. In elderly rats, a decrease was observed in the percentages of CD23+ lymphocytes from mesenteric lymph nodes, spleen, Peyer's patches and peripheral blood. In addition, these lymphocytes expressed significantly fewer CD23 molecules per cell. Almost all CD23+ cells belonged to the B lineage and were bearing both IgM and IgD on their membranes. It is suggested that a decrease in the number of both IgM+IgD+CD23+ lymphocytes and CD23 molecules per cell may contribute to immune deficiency in the elderly.
Chavez
V
V
University of Louvain, Faculty of Medicine, Experimental Immunology Unit, Brussels, Belgium.
Parreira Soares
M
M
Bazin
H
H
D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis*; D005260:Female; D015870:Gene Expression; D007073:Immunoglobulin E / Q000378:metabolism; D007075:Immunoglobulin M / Q000032:analysis; D016130:Immunophenotyping; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011961:Receptors, Fc / Q000096:biosynthesis*; D017455:Receptors, IgE
D000944:Antigens, Differentiation, B-Lymphocyte; D007075:Immunoglobulin M; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E