Lifetime prevalence of major depression and its effect on treatment outcome in obese type II diabetic patients.
OBJECTIVE
To assess the lifetime prevalence of major depression (MD) and its relation to glycemic control among a group of non-insulin-dependent (type II) diabetic subjects seeking obesity treatment and to determine whether a history of MD affected response to treatment.


METHODS
Sixty-six obese subjects with type II diabetes (22 men, 44 women) completed the Inventory to Diagnose Depression-Lifetime Version before a 52-wk behavioral weight-control program. Weight, glycosylated hemoglobin, fasting blood glucose, and mood were assessed at pre- and posttreatment.


RESULTS
Thirty-two percent of the subjects reported a history of MD. Neither a history of MD nor current depressive symptoms were associated with pretreatment glycemic control. However, a history of MD was related to treatment attrition (52.4 vs. 22.2%, P = 0.03). Subjects with and without a history of MD showed comparable improvements in weight, glycemic control, and mood.


CONCLUSIONS
A history of MD among type II diabetic patients seeking obesity treatment was not related to pretreatment glycemic control but was associated with higher rates of attrition from treatment. Individuals with a history of MD who completed the program did not differ from those with no history of MD in response to treatment.
Marcus
M D
MD
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania.
Wing
R R
RR
Guare
J
J
Blair
E H
EH
Jawad
A
A
D000328:Adult; D000368:Aged; D001521:Behavior Therapy; D001786:Blood Glucose / Q000378:metabolism; D003866:Depressive Disorder / Q000150:complications* / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000523:psychology* / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000523:psychology* / Q000628:therapy; D003927:Diet, Diabetic; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D015995:Prevalence; D016896:Treatment Outcome
D001786:Blood Glucose; D006442:Glycated Hemoglobin