Induction of dyspnea by aerosol of endothelin-1/histamine or/methacholine in the conscious guinea pig.
The inhalation of aerosol of endothelin-1 (ET-1) induced dyspneal behavior in conscious guinea pigs pretreated with histamine or methacholine inhalation, although it was not observed by the inhalation of ET-1 alone. The dyspneal response to the inhalation of ET-1/histamine was potently inhibited by indomethacin, but it was not affected by nifedipine or diphenhydramine.
Koshi
T
T
Tokyo Research Laboratories, Kowa Co., Ltd., Japan.
Etoh
Y
Y
Torii
T
T
Wada
Y
Y
Hirata
M
M
Ohkuchi
M
M
Okabe
T
T
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D003243:Consciousness; D004347:Drug Interactions; D004417:Dyspnea / Q000139:chemically induced*; D016232:Endothelins / Q000008:administration & dosage; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage; D013997:Time Factors
D000336:Aerosols; D016232:Endothelins; D016210:Methacholine Chloride; D006632:Histamine