Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.
Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.
Wolinsky
S M
SM
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
Wike
C M
CM
Korber
B T
BT
Hutto
C
C
Parks
W P
WP
Rosenblum
L L
LL
Kunstman
K J
KJ
Furtado
M R
MR
Muñoz
J L
JL
D000163:Acquired Immunodeficiency Syndrome / Q000151:congenital / Q000382:microbiology / Q000635:transmission*; D000595:Amino Acid Sequence; D001483:Base Sequence; D005260:Female; D005838:Genotype; D006031:Glycosylation; D015488:HIV Antigens / Q000235:genetics; D015699:HIV Envelope Protein gp120 / Q000235:genetics / Q000276:immunology; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007223:Infant; D008431:Maternal-Fetal Exchange; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D012641:Selection, Genetic; D016415:Sequence Alignment
D015488:HIV Antigens; D015699:HIV Envelope Protein gp120; D009838:Oligodeoxyribonucleotides