Presumptive trimethoprim-sulfadiazine-related hepatotoxicosis in a dog.
Administration of trimethoprim-sulfadiazine in a dog was associated with vomiting, inappetence, and icterus, and high values of alanine transaminase, aspartate transaminase, alkaline phosphatase, gamma-glutamyltransferase, and total bilirubin concentration. The clinical signs and biochemical abnormalities resolved after discontinuation of the treatment. Histologic examination of sections from a liver biopsy specimen revealed moderate, predominantly portal hepatitis with cholestasis.
Rowland
P H
PH
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
Center
S A
SA
Dougherty
S A
SA
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D004338:Drug Combinations; D005500:Follow-Up Studies; D008099:Liver / Q000187:drug effects; D008107:Liver Diseases / Q000662:veterinary*; D008297:Male; D011711:Pyoderma / Q000188:drug therapy / Q000662:veterinary*; D013411:Sulfadiazine / Q000009:adverse effects* / Q000627:therapeutic use; D014295:Trimethoprim / Q000009:adverse effects* / Q000627:therapeutic use
D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim