title: Simultaneous injection of hepatitis B vaccine with BCG and killed poliovirus vaccine.
abstract: In most developing countries, hepatitis B virus is endemic and prevention has to be carried out early in life and on a mass scale. In these regions, simultaneous administration of multiple antigens is normal practice. We have therefore investigated the interaction of hepatitis B vaccine with BCG and inactivated polio vaccine. The serological antibody response to poliovirus and HBsAg as well as the cellular immune response to tuberculin post BCG immunization were assessed. The immune responses to HBsAg, BCG and polio vaccines injected simultaneously were comparable to those observed after separate administration of each vaccine. Moreover, no increase of adverse reactions was noted. Results confirmed that HB vaccine could be introduced into the WHO expanded programmes on immunization without impairing the expected protective efficacy against the targeted vaccine-preventable diseases.
authors.affiliation: Institut de Virologie et Laboratoire de Microbiologie, Faculté de Pharmacie, Tours, France.
authors.forename: P
authors.initials: P
authors.lastname: Coursaget
authors.forename: E
authors.initials: E
authors.lastname: Relyveld
authors.forename: A
authors.initials: A
authors.lastname: Brizard
authors.forename: M P
authors.initials: MP
authors.lastname: Frenkiel
authors.forename: B
authors.initials: B
authors.lastname: Fritzell
authors.forename: L
authors.initials: L
authors.lastname: Teulières
authors.forename: C
authors.initials: C
authors.lastname: Bourdil
authors.forename: B
authors.initials: B
authors.lastname: Yvonnet
authors.forename: E
authors.initials: E
authors.lastname: Jeannée
authors.forename: S
authors.initials: S
authors.lastname: Guindo
mesh_terms: D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D017325:Hepatitis B Vaccines; D006801:Humans; D007114:Immunization; D007231:Infant, Newborn; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D001500:BCG Vaccine; D017325:Hepatitis B Vaccines; D011054:Poliovirus Vaccine, Inactivated; D015164:Vaccines, Inactivated; D014761:Viral Hepatitis Vaccines