title: Absence of structural rearrangements of chromosome 11 in human primary malignant melanoma.
abstract: Cytogenetic analysis of 10 primary and 18 metastatic malignant melanomas revealed that structural abnormalities of chromosome 11 were present in 50% of metastatic lesions and were not found in primary tumors. Our findings suggest that chromosome 11 aberrations represent secondary changes in malignant melanoma tumorigenesis.
authors.affiliation: Department of Biology and Genetics, Medical Academy, Gdańsk, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Nedoszytko
authors.forename: K
authors.initials: K
authors.lastname: Mrózek
authors.forename: J
authors.initials: J
authors.lastname: Limon
mesh_terms: D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D002999:Clone Cells; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D014407:Tumor Cells, Cultured