5-HT3 receptor antagonists reverse helpless behaviour in rats.
The effects of the 5-HT3 receptor antagonists, zacopride, ondansetron and ICS 205-930, were investigated in an animal model of depression, the learned helplessness test. Rats previously subjected to a session of 60 inescapable foot-shocks exhibited a deficit of escape performance in three subsequent shuttle-box sessions. The 5-HT3 receptor antagonists administered i.p. twice daily on a chronic schedule (zacopride 0.03-2 mg/kg per day; ondansetron and ICS 205-930: 0.125-2 mg/kg per day) reduced the number of escape failures at low to moderate daily doses. This effect was not observed with the highest dose(s) of zacopride, ondansetron and ICS 205-930 tested. These results indicate that 5-HT3 antagonists may have effects like those of conventional antidepressants in rats.
Martin
P
P
Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Gozlan
H
H
Puech
A J
AJ
D000704:Analysis of Variance; D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000627:therapeutic use*; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D006380:Helplessness, Learned; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D007211:Indoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D017294:Ondansetron; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists; D000077526:Tropisetron
D001549:Benzamides; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D007093:Imidazoles; D007211:Indoles; D012702:Serotonin Antagonists; D017294:Ondansetron; D000077526:Tropisetron; C055971:zacopride