title: Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells.
abstract: A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) which could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 microM, blocks arachidonate metabolism.
authors.affiliation: CJF INSERM 88-03, Faculté de Médecine, Université de Limoges, France.
authors.forename: A
authors.initials: A
authors.lastname: Najid
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Cook
authors.forename: H
authors.initials: H
authors.lastname: Chable-Rabinovitch
authors.forename: C
authors.initials: C
authors.lastname: Delage
authors.forename: A J
authors.initials: AJ
authors.lastname: Chulia
authors.forename: M
authors.initials: M
authors.lastname: Rigaud
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007942:Leukemia, Experimental; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000097245:Ursolic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D014315:Triterpenes; D000097245:Ursolic Acid