Active avoidance learning in old rats chronically treated with levocarnitine acetyl.
The aging laboratory animal is recognized as a suitable experimental model for the investigation on drugs potentially able to retard the age-dependent decline in cognitive functions. There is robust evidence that levocarnitine acetyl (ALCAR), the acetyl derivative of carnitine, when administered chronically, prevents some age-related deficits of the central nervous system, mainly at the hippocampal level. On the basis of this evidence and because learning of active avoidance was demonstrated to become impaired with age, we decided to investigate the effect of ALCAR in rats. For statistical evaluation of results, the Cluster Analysis technique was chosen. This procedure pointed out the great heterogeneity of the old population and allowed the classification of the animals into homogeneous groups according to their response pattern. The effect of ALCAR was evident in the higher number of treated old animals yielding escape responses, indicating that ALCAR can preserve, at least partially, learning and memory from the natural decay occurring with age.
Ghirardi
O
O
Institute for Research on Senescence, Sigma Tau S.p.A., Pomezia, Rome, Italy.
Caprioli
A
A
Milano
S
S
Giuliani
A
A
Ramacci
M T
MT
Angelucci
L
L
D000108:Acetylcarnitine / Q000494:pharmacology*; D000375:Aging / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D016000:Cluster Analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000108:Acetylcarnitine