title: Histatins 2 and 4 are autoproteolytic degradation products of human parotid saliva.
abstract: Freshly collected human parotid saliva contains 8 cationic proteins, as demonstrated by capillary electrophoresis. These proteins include lysozyme, histatin 6 and the 6 salivary histidine-rich polypeptides (HRPs 1-6). Neither histatin 2 nor histatin 4 are present in native undegraded parotid saliva but appear only after autoproteolytic degradation of the saliva. Histatin 2 appears to arise through slow degradation of HRP-1, and histatin 4 is mainly produced as a rapid breakdown product of HRP-3.
authors.affiliation: School of Dental Medicine, State University of New York, Stony Brook.
authors.forename: L
authors.initials: L
authors.lastname: Xu
authors.forename: K
authors.initials: K
authors.lastname: Lal
authors.forename: J J
authors.initials: JJ
authors.lastname: Pollock
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D008969:Molecular Sequence Data; D010306:Parotid Gland / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry*; D012471:Salivary Proteins and Peptides / Q000378:metabolism*; D000099053:Histidine-Rich Glycoprotein
chemical_list: D011506:Proteins; D012471:Salivary Proteins and Peptides; D000099053:Histidine-Rich Glycoprotein