Regulation of IL-2 production by mononuclear cells from rheumatoid arthritis synovial fluids.
Products of polyamine oxidation down-regulate IL-2 production by peripheral blood T cells. We show here that the production of IL-2 by rheumatoid arthritis synovial fluid mononuclear cells is inversely correlated with the concentrations of polyamines in these cells. In addition, the inhibition of polyamine biosynthesis or oxidation in cultures of these cells enhances their ability to produce IL-2. Our findings suggest that polyamine oxidation plays an important role in the suppression of T cell function characteristic of rheumatoid arthritis synovial fluids.
Flescher
E
E
University of Texas Health Science Center, San Antonio 78284-7874.
Bowlin
T L
TL
Talal
N
N
D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D009952:Ornithine / Q000031:analogs & derivatives / Q000494:pharmacology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors; D011073:Polyamines / Q000037:antagonists & inhibitors; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011700:Putrescine / Q000031:analogs & derivatives / Q000494:pharmacology; D013582:Synovial Fluid / Q000276:immunology / Q000378:metabolism*
D007376:Interleukin-2; D011073:Polyamines; D011448:Prostaglandin Antagonists; C044445:MDL 72527; C025025:alpha-methylornithine; D009952:Ornithine; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011700:Putrescine