[Antitumor effect of liposome-entrapped carboplatin after intraperitoneal administration in rats].
We examined the distribution in tissue and antitumor effects of freeze-dried liposome-entrapped carboplatin (Lipo-CBDCA) after intraperitoneal administration to rats bearing AH 130 tumors. Liposomes composed of egg lecithin and cholesterol were used as drug carriers. The serum concentration of platinum was decreased for a short time after the intraperitoneal administration of Lipo-CBDCA. After at least 3 hours, the serum concentration of platinum was higher with free CBDCA intraperitoneal or intravenous administration. The antitumor effects of Lipo-CBDCA were determined in rats with peritoneal dissemination due to AH 130 tumors. Intraperitoneal Lipo-CBDCA prolonged the life span of the tumor-bearing rats. No side effects of the chemotherapy were demonstrated in biochemical and histological studies in the liver, kidney, spleen and small intestine. These results indicate that intraperitoneal chemotherapy with Lipo-CBDCA may be more effective than that with free CBDCA managing in peritoneal dissemination, and may be therapeutically useful without toxic side effects.
Yasui
T
T
First Dept. of Surgery, Medical School, Nagoya City University.
Mizuno
I
I
Ichino
T
T
Akamo
Y
Y
Yamamoto
T
T
Itabashi
Y
Y
Saito
T
T
Kurahashi
S
S
Tanimoto
N
N
Yura
J
J
D000818:Animals; D016190:Carboplatin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers; D007263:Infusions, Parenteral; D007668:Kidney / Q000378:metabolism; D008081:Liposomes; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010538:Peritonitis / Q000188:drug therapy / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains
D004337:Drug Carriers; D008081:Liposomes; D016190:Carboplatin