title: Noninvasive glucose monitoring in diabetic patients: a preliminary evaluation.
abstract: Noninvasive monitoring of blood/tissue glucose concentrations has been successfully accomplished in individual diabetic subjects by using near-infrared (NIR) spectroscopy coupled with chemometric methods. Three different spectrometer configurations were tested: a) a Fourier-transform infrared spectrometer with an indium antimonide detector; b) a grating monochromator equipped with a silicon (Si) array detector, without fiber optics; and c) a grating monochromator equipped with an Si detector, with fiber-optic sampling. NIR spectra were obtained from diabetic subjects by transmission through the finger during a meal-tolerance test. The maximum range of observed plasma glucose concentrations obtained from the blood samples was 2.5-27 mmol/L. The NIR spectra were processed by using the chemometric multivariate calibration methods of partial least squares and principal component regression. The best calibration yielded a cross-validated average absolute error in glucose concentration of 1.1 mmol/L. This predictive ability suggests that noninvasive glucose determinations by NIR/chemometrics is a viable analytical method.
authors.affiliation: University of New Mexico School of Medicine, Albuquerque 87131.
authors.forename: M R
authors.initials: MR
authors.lastname: Robinson
authors.forename: R P
authors.initials: RP
authors.lastname: Eaton
authors.forename: D M
authors.initials: DM
authors.lastname: Haaland
authors.forename: G W
authors.initials: GW
authors.lastname: Koepp
authors.forename: E V
authors.initials: EV
authors.lastname: Thomas
authors.forename: B R
authors.initials: BR
authors.lastname: Stallard
authors.forename: P L
authors.initials: PL
authors.lastname: Robinson
mesh_terms: D001786:Blood Glucose / Q000032:analysis*; D002138:Calibration; D003920:Diabetes Mellitus / Q000097:blood*; D005069:Evaluation Studies as Topic; D006801:Humans; D012044:Regression Analysis; D013055:Spectrophotometry, Infrared
chemical_list: D001786:Blood Glucose