[Intra-arterial chemotherapy of local recurrence and non-curative case of colorectal cancer].
Twelve colorectal cancer patients, including 9 with local recurrent cancer and 3 with remnant cancer after surgery, were treated with intraarterial chemotherapy. Three cases were treated with MMC injection alone, 1 case with MMC combined with irradiation (MMC-R) and 8 cases with ADM combined with irradiation (ADM-R). In 7 evaluable patients, the response rate was 28.6% with 1 CR case, 1 PR case and 5 NC cases. The 2 cases treated with ADM-R were successful. Six of 8 patients treated with ADM-R survived more than 1 year, while all 4 patients treated with MMC or MMC-R died within 8 months. The cumulative survival rate after ADM-R treatment was 44% at 24 months. It is suggested that the combination of intra-arterial chemotherapy and radiation therapy is an effective treatment for local recurrence and non-curative cases of colorectal cancer.
Hashimoto
M
M
Dept. of Surgery, Social Insurance Saitama Chuo Hospital.
Murayama
Y
Y
Sano
M
M
Katai
H
H
Maeda
K
K
Sakai
S
S
Koh
J
J
Yamamoto
O
O
Hosoda
Y
Y
Suzuki
K
K
D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D004317:Doxorubicin / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D016685:Mitomycin / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D011379:Prognosis; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D015996:Survival Rate
D016685:Mitomycin; D004317:Doxorubicin