Photochemistry of tiaprofenic acid, a nonsteroidal anti-inflammatory drug with phototoxic side effects.
The phototoxic nonsteroidal anti-inflammatory drug tiaprofenic acid (1) is photolabile under aerobic conditions. Irradiation of a methanol solution of 1 under oxygen produces the photoproducts 2, 3, 4, and 5, and also produces a singlet oxygen as evidenced by trapping with 2,5-dimethylfuran.
Boscá
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F
Departamento de Quimica, Universidad Politécnica de Valencia, Spain.
Miranda
M A
MA
Vargas
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F
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000737:chemistry*; D006801:Humans; D010777:Photochemistry; D010787:Photosensitivity Disorders / Q000209:etiology; D011422:Propionates / Q000009:adverse effects / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011422:Propionates; C021270:tiaprofenic acid