title: GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.
abstract: Sequence comparison of Drosophila melanogaster glucose dehydrogenase, Escherichia coli choline dehydrogenase, Aspergillus niger glucose oxidase and Hansenula polymorpha methanol oxidase indicates that these four diverse flavoproteins are homologous, defining a new family of proteins named the GMC oxidoreductases. These enzymes contain a canonical ADP-binding beta alpha beta-fold close to their amino termini as found in other flavoenzymes. This domain is encoded by a single exon of the D. melanogaster glucose dehydrogenase gene.
authors.affiliation: Department of Molecular Biology, Vanderbilt University, Nashville, TN 37235.
authors.forename: D R
authors.initials: DR
authors.lastname: Cavener
mesh_terms: D000429:Alcohol Oxidoreductases / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001419:Bacteria / Q000201:enzymology; D002384:Catalysis; D050545:Choline Dehydrogenase; D004331:Drosophila melanogaster / Q000201:enzymology; D005658:Fungi / Q000201:enzymology; D042843:Glucose 1-Dehydrogenase; D005948:Glucose Dehydrogenases / Q000737:chemistry / Q000378:metabolism; D005949:Glucose Oxidase / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D010088:Oxidoreductases / Q000737:chemistry / Q000145:classification* / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid
chemical_list: D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D005948:Glucose Dehydrogenases; D042843:Glucose 1-Dehydrogenase; D005949:Glucose Oxidase; C029293:methanol oxidase; D050545:Choline Dehydrogenase