Stromal amyloid in pheochromocytomas.
Amyloid has been documented in the stroma of a number of neuroendocrine tumors. It is usually associated with elaboration of a polypeptide hormone product. Twenty-three adrenal pheochromocytomas occurring in 18 patients were graded for the extent of amyloid deposits on the hematoxylin-eosin-stained slides, confirmed to be amyloid by Congo red stain and polarization microscopy. Fourteen of 20 cases (70%) showed evidence of stromal amyloid; in two thirds of these cases, it was considered abundant. The awareness of amyloid deposits in approximately 70% of pheochromocytomas is important for surgical pathologists, as this occurrence has not been thought to be common in these tumors and might be a source of diagnostic difficulty.
Steinhoff
M M
MM
Department of Pathology, Washington University Medical School, St. Louis, MO.
Wells
S A
SA
DeSchryver-Kecskemeti
K
K
D000310:Adrenal Gland Neoplasms / Q000737:chemistry* / Q000648:ultrastructure; D000682:Amyloid / Q000032:analysis*; D003224:Congo Red; D006801:Humans; D010673:Pheochromocytoma / Q000737:chemistry* / Q000648:ultrastructure
D000682:Amyloid; D003224:Congo Red