title: Laser Doppler measurements of skin blood flow before, during, and after lumbar sympathetic blockade in children and young adults with reflex sympathetic dystrophy syndrome.
abstract: Changes in the skin capillary blood flow (SBF) and temperature before, during, and 1 hour after unilateral lumbar paravertebral sympathetic blockade (LSB) were studied simultaneously with laser Doppler flowmetry and thermometry in patients with reflex sympathetic dystrophy syndrome. The baseline flow measurements in the toes on the affected limb were significantly lower than in the contralateral limb (p less than 0.01). During LSB, a 10-fold increase in SBF was detected within 4 minutes after injection of a local anesthetic agent when the sympathetic blockade was effective; an increase of more than 1 degrees C in the skin temperature occurred within 11 minutes. Measurements 1 hour after blockade showed an 18-fold (mean) increase in SBF in the toes (p less than 0.0001) and a 2-fold (mean) increase in SBF in the thighs (p less than 0.001). There was a significant decrease in the skin blood flow in the contralateral toes after the sympathetic blockade (p less than 0.01). We conclude that laser Doppler flow measurements can be used to detect immediate onset of sympathetic blockade in patients under general anesthetic or conscious sedation.
authors.affiliation: Department of Anaesthesia, Harvard Medical School, Boston, MA.
authors.forename: J E
authors.initials: JE
authors.lastname: Irazuzta
authors.forename: C B
authors.initials: CB
authors.lastname: Berde
authors.forename: N F
authors.initials: NF
authors.lastname: Sethna
mesh_terms: D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D001340:Autonomic Nerve Block; D002648:Child; D016292:Procedural Sedation; D005260:Female; D006801:Humans; D007834:Lasers; D008297:Male; D008833:Microcirculation / Q000502:physiology; D012019:Reflex Sympathetic Dystrophy / Q000503:physiopathology / Q000628:therapy*; D012039:Regional Blood Flow / Q000502:physiology; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature / Q000502:physiology; D013116:Spinal Cord; D013848:Thigh / Q000098:blood supply; D014034:Toes / Q000098:blood supply