Opioid-dopaminergic mechanisms in the potentiation of d-amphetamine discrimination by interferon-alpha.
In rats trained to discriminate 0.8 mg/kg IP d-amphetamine from 1 ml/kg saline, 4 x 10(6) U/kg of recombinant human interferon-alpha (rIFN-alpha) given intramuscularly 1 h prior to tests potentiated responses elicited by 0.4 mg/kg d-amphetamine. Coadministration of the opioid receptor antagonist naloxone (1 mg/kg IP) with rIFN-alpha suppressed the potentiation of d-amphetamine by the cytokine. Opioid-dopaminergic mechanisms are proposed to explain the action of rIFN-alpha.
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BT
Department of Neuro-Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Huo
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Lu
J G
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Tansey
L W
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Levin
V A
VA
D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology*; D004723:Endorphins / Q000502:physiology*; D005108:Extinction, Psychological / Q000187:drug effects; D016898:Interferon-alpha / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D016898:Interferon-alpha; D003913:Dextroamphetamine; D004298:Dopamine