[Oligoclonal bands of four IgG subfractions and IgM and IgA in the serum and cerebrospinal fluid of friends with multiple sclerosis].
Using the methods of isoelectric focusing and immunoblotting the CSF and serum immunoglobulins were analysed in 47 patients with multiple sclerosis and 57 patients with other neurological diseases. The oligoclonal bands were found in the IgG fraction in 42 multiple sclerosis (ms) patients and 13 controls. The percent proportion of oligoclonal bands in various IgG subfractions was similar in both groups and was: 66% and 61% respectively for IgG1, 22% and 22% for IgG3, 12% and 17% for IgG2. In no case was IgG4 found. Additionally sporadic oligoclonality of IgA and IgM in CSF was found. Positive results were obtained in 2 and 2 cases with ms, and in one control case (only IgA), among controls the oligoclonal bands were found most frequently in neuroinfections (38.5%) and polyneuropathy (20.5%).
Warecka
K
K
Kliniki Neurologicznej Uniwersytetu Medycznego w Lubece i z Instytutu Badawczego w Borsel, Niemcy.
Schnackenberg
K
K
Hass
H
H
Brinkmann
G
G
Kulczycki
J
J
D006801:Humans; D015151:Immunoblotting; D007070:Immunoglobulin A / Q000134:cerebrospinal fluid*; D007128:Immunoglobulin Fragments / Q000032:analysis*; D007075:Immunoglobulin M / Q000134:cerebrospinal fluid*; D007525:Isoelectric Focusing; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000276:immunology*
D007070:Immunoglobulin A; D007128:Immunoglobulin Fragments; D007075:Immunoglobulin M
Oligoklonalność w zakresie czterech podfrakcji IgG oraz IgM i IgA płynu mózgowo-rdzeniowego i surowicy u chorych na stwardnienie rozsiane.