title: The distribution of cis- and trans-acitretin in human epidermis.
abstract: The concentrations of trans-acitretin and its principal metabolite, cis-acitretin, were measured by h.p.l.c. after single and multiple dosing (50 mg orally for 13 days) in plasma, blister fluid and epidermal samples from four healthy male volunteers. Within-day epidermal concentrations of trans-acitretin exceeded those of the cis-form which were at the limit of assay sensitivity. No accumulation of trans-acitretin was observed in plasma or blister fluid but AUC values for the drug in blister roof cells tended to be higher after multiple dosing.
authors.affiliation: Laboratoria voor Medische Biochemie en voor Klinische Analyse, Gent, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Meyer
authors.forename: W
authors.initials: W
authors.lastname: Lambert
authors.forename: A
authors.initials: A
authors.lastname: De Leenheer
authors.forename: J
authors.initials: J
authors.lastname: De Bersaques
authors.forename: A
authors.initials: A
authors.lastname: Kint
mesh_terms: D017255:Acitretin; D000328:Adult; D001768:Blister / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004817:Epidermis / Q000378:metabolism*; D006801:Humans; D008297:Male; D013237:Stereoisomerism; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D014212:Tretinoin; D017255:Acitretin