title: Increased PIVKA-II concentrations in patients with cystic fibrosis.
abstract: Serum vitamin K concentrations and prothrombin induced by absence of vitamin K (PIVK-II) concentrations were assayed in 43 patients with cystic fibrosis. Twenty nine showed a normal PIVKA-II and vitamin K concentrations; 14 showed an increased PIVKA-II concentration, in one of whom serum vitamin K was decreased. Although their vitamin K concentrations were normal, some patients with cystic fibrosis still had an increased PIVKA-II. There was a significant correlation between PIVKA-II concentrations and the administration of antibiotics, a factor which has not previously been considered responsible for an increase in PIVKA-II.
authors.affiliation: Département de Pédiatrie, Hôpital des Enfants-Malades, Paris.
authors.forename: M
authors.initials: M
authors.lastname: de Montalembert
authors.forename: G
authors.initials: G
authors.lastname: Lenoir
authors.forename: A
authors.initials: A
authors.lastname: Saint-Raymond
authors.forename: J
authors.initials: J
authors.lastname: Rey
authors.forename: J J
authors.initials: JJ
authors.lastname: Lefrère
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007223:Infant; D011516:Prothrombin / Q000032:analysis*; D014810:Vitamin E / Q000097:blood; D014812:Vitamin K / Q000097:blood*; D014813:Vitamin K Deficiency / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D014812:Vitamin K; D014810:Vitamin E; D011516:Prothrombin