Growth plate injury of the long bones in treated beta-thalassemia.
In 12 patients affected by thalassemia major who received an intensive transfusion regimen combined with continuous iron chelation therapy (desferrioxamine 50-80 mg/kg daily), radiologic abnormalities of the long bones were observed similar to those observed in rickets and scurvy. These abnormalities were associated with a growth retardation. The pathogenesis of these lesions is uncertain, but probably the toxic effect of desferrioxamine plays an important role in their development. A relative deficiency of vitamins D and/or C cannot be entirely excluded.
Orzincolo
C
C
Department of Radiology, St. Anna Hospital, Ferrara, Italy.
Scutellari
P N
PN
Castaldi
G
G
D000293:Adolescent; D015913:Chelation Therapy / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003676:Deferoxamine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000139:chemically induced / Q000000981:diagnostic imaging; D006132:Growth Plate / Q000000981:diagnostic imaging / Q000187:drug effects*; D006801:Humans; D007501:Iron; D008297:Male; D011859:Radiography; D013789:Thalassemia / Q000628:therapy*
D007501:Iron; D003676:Deferoxamine