Induction of cellular chaos during quinidine toxicity. Predictive power of nonlinear dynamic analysis for drug-induced proarrhythmia--a hypothesis.
Karagueuzian
H S
HS
Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
Kogan
B Y
BY
Khan
S S
SS
Denton
T A
TA
Karplus
W J
WJ
Mandel
W J
WJ
Diamond
G A
GA
D000818:Animals; D002304:Cardiac Pacing, Artificial; D003198:Computer Simulation; D004285:Dogs; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D008297:Male; D011690:Purkinje Fibers / Q000503:physiopathology*; D011802:Quinidine / Q000009:adverse effects*; D013610:Tachycardia / Q000139:chemically induced* / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000139:chemically induced* / Q000503:physiopathology
D011802:Quinidine