Functional analysis of human T cell subsets defined by CD45 isoform expression.
The properties of human CD45RA and CD45RO T cells are described. CD45RO cells respond to recall antigens and provide help for B lymphocytes. They produce a wide variety of cytokines including IL-2, IL-4 and IFN-gamma. CD45RA T cells respond poorly to recall antigens and produce mainly IL-2. The phenotype of CD45RO cells suggests that they may be in cycle and in vivo data shows that they have a short lifespan while CD45RA cells are long-lived. The lineage relationship of the two subsets is not clear but in vivo and in vitro evidence suggests bi-directional conversion between CD45RA and CD45RO phenotypes.
Beverley
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PC
Imperial Cancer Research Fund Human Tumour Immunology Group, University College and Middlesex School of Medicine, London, UK.
D015703:Antigens, CD / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D002454:Cell Differentiation; D002465:Cell Movement; D002470:Cell Survival; D016207:Cytokines / Q000378:metabolism; D015870:Gene Expression; D006649:Histocompatibility Antigens / Q000032:analysis* / Q000235:genetics / Q000502:physiology; D006801:Humans; D007156:Immunologic Memory; D017493:Leukocyte Common Antigens; D008213:Lymphocyte Activation; D012326:RNA Splicing; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D016207:Cytokines; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens