title: [Correlations between plasma concentrations of atrial natriuretic factor and right ventricular function in patients with severe cardiac failure].
abstract: The atrial natriuretic factor (ANF) is secreted by the atria in mild and moderate cardiac failure but, during the evolution of the cardiac failure, the ventricles are also recruited and secrete ANF. In order to investigate the relation between plasma ANF and Doppler echocardiographic parameters of severe cardiac failure, the concentrations were measured simultaneously in 20 patients with NYHA Class III and IV cardiac failure (10 due to ischaemic and 10 due to primary dilated cardiomyopathy) despite optimal medical treatment including an angiotensin converting enzyme inhibitor. Overall, there was a weak negative correlation between the plasma ANF concentrations and the decrease in right ventricular surface area (r = -0.58, p less than 0.005, n = 20 patients). This relation was highly significant in ischaemic cardiomyopathy (r = -0.81, p less than 0.002, n = 10 patients) and not significant in primary dilated cardiomyopathy (r = -0.29, NS, n = 10 patients). No relationship was observed between plasma ANF and other echocardiographic parameters (atrial surface area, right and left ventricular dimensions, left ventricular ejection fraction and mass) or with Doppler aortic indices (acceleration, maximum and mean velocities, aortic velocity-time integrals). However, plasma ANF was related to the velocity of mitral regurgitant jets (r = -0.70, p less than 0.01) which is dependent on left ventricular pump function. These results show that plasma ANF concentrations are only related to right ventricular systolic function and the velocity of mitral regurgitation in patients with severe cardiac failure.
authors.affiliation: Service de cardiologie, hôpital Ambroise-Paré, Boulogne.
authors.forename: J F
authors.initials: JF
authors.lastname: Arnal
authors.forename: G
authors.initials: G
authors.lastname: Delorme
authors.forename: O
authors.initials: O
authors.lastname: Dubourg
authors.forename: E
authors.initials: E
authors.lastname: Pussard
authors.forename: A
authors.initials: A
authors.lastname: Beauchet
authors.forename: G
authors.initials: G
authors.lastname: Jondeau
authors.forename: H
authors.initials: H
authors.lastname: Sahraie
authors.forename: A
authors.initials: A
authors.lastname: Berdeaux
authors.forename: J P
authors.initials: JP
authors.lastname: Bourdarias
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D009320:Atrial Natriuretic Factor / Q000097:blood*; D004452:Echocardiography; D006333:Heart Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D009638:Norepinephrine / Q000097:blood; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right
chemical_list: D009320:Atrial Natriuretic Factor; D009638:Norepinephrine
vernacular_title: Corrélation entre les concentrations plasmatiques de facteur atrial natriurétique et la fonction ventriculaire droite chez des patients en insuffisance cardiaque sévère.