title: Effect of growth hormone and resistance exercise on muscle growth in young men.
abstract: The purpose of this study was to determine whether growth hormone (GH) administration enhances the muscle anabolism associated with heavy-resistance exercise. Sixteen men (21-34 yr) were assigned randomly to a resistance training plus GH group (n = 7) or to a resistance training plus placebo group (n = 9). For 12 wk, both groups trained all major muscle groups in an identical fashion while receiving 40 micrograms recombinant human GH.kg-1.day-1 or placebo. Fat-free mass (FFM) and total body water increased (P less than 0.05) in both groups but more (P less than 0.01) in the GH recipients. Whole body protein synthesis rate increased more (P less than 0.03), and whole body protein balance was greater (P = 0.01) in the GH-treated group, but quadriceps muscle protein synthesis rate, torso and limb circumferences, and muscle strength did not increase more in the GH-treated group. In the young men studied, resistance exercise with or without GH resulted in similar increments in muscle size, strength, and muscle protein synthesis, indicating that 1) the larger increase in FFM with GH treatment was probably due to an increase in lean tissue other than skeletal muscle and 2) resistance training supplemented with GH did not further enhance muscle anabolism and function.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
authors.forename: K E
authors.initials: KE
authors.lastname: Yarasheski
authors.forename: J A
authors.initials: JA
authors.lastname: Campbell
authors.forename: K
authors.initials: K
authors.lastname: Smith
authors.forename: M J
authors.initials: MJ
authors.lastname: Rennie
authors.forename: J O
authors.initials: JO
authors.lastname: Holloszy
authors.forename: D M
authors.initials: DM
authors.lastname: Bier
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D001834:Body Water / Q000378:metabolism; D004032:Diet; D005951:Glucose Tolerance Test; D005998:Glycine / Q000378:metabolism; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D007930:Leucine / Q000378:metabolism; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology; D012016:Reference Values; D013997:Time Factors; D014891:Weight Lifting
chemical_list: D001786:Blood Glucose; D011506:Proteins; D011994:Recombinant Proteins; D013006:Growth Hormone; D007930:Leucine; D005998:Glycine