Mitochondrial genetics: a paradigm for aging and degenerative diseases?
Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.
Wallace
D C
DC
Department of Genetics and Molecular Medicine, Emory University School of Medicine, Atlanta, GA 30322.
D000375:Aging / Q000235:genetics*; D000544:Alzheimer Disease / Q000235:genetics; D001483:Base Sequence; D003327:Coronary Disease / Q000235:genetics; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D006816:Huntington Disease / Q000235:genetics; D008969:Molecular Sequence Data; D009135:Muscular Diseases / Q000235:genetics; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics; D010085:Oxidative Phosphorylation; D010300:Parkinson Disease / Q000235:genetics; D012343:RNA, Transfer / Q000235:genetics
D004272:DNA, Mitochondrial; D012343:RNA, Transfer