Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin.
The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R-(+)-PL in terms of penetration through rat stratum corneum.
Miyazaki
K
K
Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
Kaiho
F
F
Inagaki
A
A
Dohi
M
M
Hazemoto
N
N
Haga
M
M
Hara
H
H
Kato
Y
Y
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D011433:Propranolol / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption; D013237:Stereoisomerism
D011433:Propranolol