title: Effects of chronic maternal anemia on systemic and uteroplacental oxygenation in near-term pregnant sheep.
abstract: OBJECTIVE
  The hypothesis of our study was that both the systemic and uteroplacental circulations would adapt to chronic maternal anemia to ensure that oxygen supply to maternal tissues would be adequate.
  
  
  METHODS
  We measured cardiac output and uteroplacental blood flow and calculated systemic and uteroplacental oxygen delivery, extraction, and consumption in pregnant sheep that were anemic for 6 days (hematocrit 14%) and in normal sheep (hematocrit 28%).
  
  
  RESULTS
  When compared with normal pregnant sheep, anemic pregnant sheep had increases in cardiac output and uteroplacental blood flow, neither of which was sufficient to prevent systemic or uteroplacental oxygen delivery from decreasing. In spite of decreases in oxygen delivery, systemic and uteroplacental oxygen consumptions were maintained at normal levels because of increases in oxygen extraction.
  
  
  CONCLUSIONS
  Maternal systemic and uteroplacental circulations are capable of adapting well to chronic maternal anemia.
authors.affiliation: Department of Obstetrics, University of Pittsburgh School of Medicine, PA.
authors.forename: E H
authors.initials: EH
authors.lastname: Delpapa
authors.forename: D I
authors.initials: DI
authors.lastname: Edelstone
authors.forename: J R
authors.initials: JR
authors.lastname: Milley
authors.forename: M
authors.initials: M
authors.lastname: Balsan
mesh_terms: D000740:Anemia / Q000097:blood / Q000378:metabolism*; D000818:Animals; D002908:Chronic Disease; D005260:Female; D006439:Hemodynamics; D010101:Oxygen Consumption; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000378:metabolism*; D011270:Pregnancy, Animal / Q000378:metabolism*; D012756:Sheep; D014599:Uterus / Q000378:metabolism*