title: Thrombocytosis and hyposplenism in an infant with fetal hydantoin syndrome.
abstract: An infant boy with fetal hydantoin syndrome was evaluated for the finding of thrombocytosis. Delayed splenic maturation was identified by a decreased splenic uptake of 99mTc sulfur colloid and by an increased number of pitted erythrocytes at 6 months of age. We speculate that the patient's thrombocytosis may be related to delayed maturation of splenic function and conclude that hyposplenism and secondary thrombocytosis may be associated with fetal hydantoin syndrome.
authors.affiliation: Department of Pediatrics, Children's Hospital of Los Angeles, California 90027.
authors.forename: O
authors.initials: O
authors.lastname: Alvarez
authors.forename: J H
authors.initials: JH
authors.lastname: Miller
authors.forename: T D
authors.initials: TD
authors.lastname: Coates
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects*; D007223:Infant; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D011247:Pregnancy; D013158:Splenic Diseases / Q000139:chemically induced*; D013577:Syndrome; D013922:Thrombocytosis / Q000139:chemically induced*
chemical_list: D006827:Hydantoins