Some clotting factors in plasma during danazol therapy: free and total protein S, but not C4b-binding protein, are elevated by danazol therapy.
Anabolic steroids are known to increase the plasma concentrations of certain plasma proteins. In four patients given treatment with danazol, an attenuated androgen, the concentrations of heparin cofactor II, Hageman factor (factor XII), protein C, and both free and total protein S increased significantly when tested 39 to 103 days after the start of therapy. The titers of these proteins in samples obtained 21 days to 5 years after therapy was discontinued were similar to those before treatment, except for total protein S, the titer of which remained elevated. No significant changes in the titers of C4b binding protein or plasma plasmin inhibitory activity were found.
Thorisdottir
H
H
Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH.
Evans
J A
JA
Schwartz
H J
HJ
Comp
P
P
Haluschak
J
J
Ratnoff
O D
OD
D000328:Adult; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D015935:Complement C4b / Q000378:metabolism*; D003169:Complement Inactivator Proteins; D003613:Danazol / Q000627:therapeutic use*; D004715:Endometriosis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008297:Male; D017293:Protein S; D019896:alpha 1-Antitrypsin Deficiency
D001779:Blood Coagulation Factors; D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D017293:Protein S; D015935:Complement C4b; D003613:Danazol