title: Experimental evaluation of ten clinically used arterial prostheses.
abstract: The arterial grafts currently in use are classified into five basic categories; 10 different commercially available prostheses were chosen to represent these categories. The Vascutek and Bionit are made from knitted Dacron and have medium porosity, requiring preclotting by the surgeon. The DeBakey Soft Woven and Plasma TFE grafts are made from woven Dacron and have low porosity, not requiring preclotting under most circumstances. Also studied were woven and knitted grafts with leakage resistance referred to as "impervious" Dacron grafts: the Vascutek Gelseal, the Bard Albumin Coated DeBakey Vasculour II, the Microvel with Hemashield, and the albumin saturated, autoclaved DeBakey Soft Woven graft. Gore-Tex and Impra are expanded polytetrafluoroethylene grafts which do not require preclotting. For each type, five grafts 6 cm long and 8 mm in diameter were implanted in the descending thoracic aorta of healthy adult dogs for 16 weeks. The physical characteristics, biocompatibility, and healing patterns varied according to the structure and treatment of the grafts. Pretreatment with biomaterials during manufacture is quite effective in preventing transinterstices blood loss during implantation, but results in altered physical qualities, increased thrombogenicity and delayed healing in comparison to the effects of preclotting with autogenous blood at the time of implantation.
authors.affiliation: Hope Heart Institute, Seattle, Washington 98122.
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: R E
authors.initials: RE
authors.lastname: Arnell
authors.forename: L R
authors.initials: LR
authors.lastname: Sauvage
authors.forename: H D
authors.initials: HD
authors.lastname: Wu
authors.forename: Q
authors.initials: Q
authors.lastname: Shi
authors.forename: A R
authors.initials: AR
authors.lastname: Wechezak
authors.forename: D
authors.initials: D
authors.lastname: Mungin
authors.forename: M
authors.initials: M
authors.lastname: Walker
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D004285:Dogs; D005260:Female; D008297:Male; D008422:Materials Testing / Q000295:instrumentation*; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D014945:Wound Healing / Q000502:physiology
chemical_list: D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene