Prenatal transmission of hepatitis B virus to neonates born to serum hepatitis B virus DNA-positive mothers.
Hepatitis B virus (HBV) DNA was detected by in vitro enzymatic DNA amplification techniques in 66.7% (six of nine) of hepatitis B virus surface antigen (HBsAg)-positive and in 21.1% (7 of 33) of HBsAg-negative pregnant women. Five of the HBV DNA and HBsAg-positive women and one HBV DNA-positive but HBsAg-negative woman gave birth to infants positive for serum HBV DNA at time of birth. These results suggest that HBsAg-negative pregnant women are potentially capable of transmitting HBV DNA to their infants.
Pao
C C
CC
Department of Biochemistry, Chang Gung Medical College, Taiwan, Republic of China.
Yao
D S
DS
Lin
C Y
CY
Hsieh
T T
TT
D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006509:Hepatitis B / Q000382:microbiology / Q000635:transmission*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D007231:Infant, Newborn; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens