Cosegregation of Christmas disease and major affective disorder in a pedigree.
Three males with factor-IX deficiency (Christmas disease) in one pedigree all had severe affective disorder. This apparent cosegregation, if true, would support the hypothesis that in some pedigrees, a gene for major affective disorder is located on the X chromosome.
Gill
M
M
Institute of Psychiatry, DeCrespigny Park, London.
Castle
D
D
Duggan
C
C
D000368:Aged; D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology; D006580:Genetic Carrier Screening; D008040:Genetic Linkage / Q000235:genetics*; D002836:Hemophilia B / Q000235:genetics* / Q000523:psychology; D006801:Humans; D008297:Male; D010375:Pedigree; D012729:Sex Chromosome Aberrations / Q000235:genetics* / Q000523:psychology; D014960:X Chromosome