title: Involvement of subplate neurons in the formation of ocular dominance columns.
abstract: During development of the mammalian visual system, axon terminals of lateral geniculate nucleus (LGN) neurons, initially intermixed within layer 4 of the visual cortex, gradually segregate according to eye preference to form ocular dominance columns. In addition to LGN axons and layer 4 neurons, subplate neurons may also participate in interactions leading to column formation. Deletion of subplate neurons before the formation of ocular dominance columns prevents the segregation of LGN axons within layer 4. Thus, interactions between LGN axons and layer 4 neurons are not sufficient; subplate neurons are also required for formation of ocular dominance columns in the visual cortex.
authors.affiliation: Department of Neurobiology, Stanford University School of Medicine, CA 94305.
authors.forename: A
authors.initials: A
authors.lastname: Ghosh
authors.forename: C J
authors.initials: CJ
authors.lastname: Shatz
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001369:Axons / Q000502:physiology; D002415:Cats; D016923:Cell Death / Q000187:drug effects; D007608:Kainic Acid / Q000494:pharmacology; D009474:Neurons / Q000166:cytology* / Q000187:drug effects; D009799:Ocular Physiological Phenomena; D014793:Visual Cortex / Q000166:cytology / Q000254:growth & development*; D014795:Visual Pathways / Q000254:growth & development
chemical_list: D007608:Kainic Acid