Liquid chromatographic estimation of tranylcypromine in human plasma.
A simple, selective and quantitative estimation of tranylcypromine using liquid chromatography and electrochemical detection with apomorphine as internal standard in human plasma is described. Sample preparation is done by liquid-liquid extraction. The absolute mean recovery of apomorphine is 95%, the recovery of tranylcypromine is 81%. This method gives a simple estimation method to assay plasma concentrations of tranylcypromine in the therapeutic range (5-200 ng/ml) with good reproducibility and linearity.
Krugers Dagneaux
P G
PG
Medisch Spectrum Twente, Department of Clinical Pharmacy, Enschede, The Netherlands.
Loohuis
C P
CP
Klein Elhorst
J T
JT
Van der Veer
T S
TS
D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014191:Tranylcypromine / Q000097:blood*
D014191:Tranylcypromine