Immunological evaluation of cefodizime: a unique molecule among cephalosporins.
The immunomodulatory properties of cefodizime, a new aminothiazolyl cephalosporin, are reviewed. Cefodizime displays in vitro and ex vivo stimulatory effects on phagocyte bactericidal function. It also increases certain lymphocyte responses, including delayed type hypersensitivity and antibody production. In addition, it restores various immune functions in immunocompromised animals and humans. The immunomodulating activity of this drug is further supported by its in vivo efficacy in experimental models of infections using cefodizime-sensitive or -resistant pathogens. Cefodizime appears to be a promising molecule, exhibiting potent antimicrobial activity and exerting potentially beneficial effects on the immune system.
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INSERM U 294, Laboratoire d'Immunologie et d'Hématologie, CHU Xavier Bichat, Paris, France.
D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000472:pathogenicity; D002439:Cefotaxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D014774:Virulence / Q000187:drug effects
D007155:Immunologic Factors; D002439:Cefotaxime; C033356:cefodizime