title: Breast cancer with extensive intraductal component: treatment with immediate interstitial boost irradiation.
abstract: Extensive intraductal component (EIC) has been reported to have a prominent role in local recurrence after treatment of early-stage breast cancer with lumpectomy and irradiation. Pathologic specimens from 250 breasts (245 patients) treated between June 1982 and June 1990 with lumpectomy, immediate (boost) interstitial iridium-192 to 15-20 Gy, and external-beam irradiation to the entire breast to 45-50 Gy were reviewed. EIC was present in 61 breasts. At a median follow-up period of 58 months (range, 14-110 months), there were 10 recurrences in the 250 treated breasts. Of these 10, three were in patients from the group with EIC. The 10-year actuarial recurrence rates in breasts with and without EIC were 9.1% and 5.2%, respectively. The difference between the two rates was not significant. If an immediate boost with interstitial iridium is used in therapy, the influence of EIC on local failure is insignificant.
authors.affiliation: Department of Radiation Oncology, University of Kansas Medical Center, Kansas City 66103.
authors.forename: L
authors.initials: L
authors.lastname: Krishnan
authors.forename: W R
authors.initials: WR
authors.lastname: Jewell
authors.forename: E C
authors.initials: EC
authors.lastname: Krishnan
authors.forename: R
authors.initials: R
authors.lastname: Cherian
authors.forename: F
authors.initials: F
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002277:Carcinoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008722:Methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local