title: Phagocytic and bactericidal function of mouse macrophages to Salmonella typhimurium in schistosomiasis mansoni.
abstract: Patients infected with schistosomes may develop a clinical picture of chronic salmonellosis. We have investigated the altered function of macrophages capable of playing a role in the development of chronic salmonellosis associated with Schistosoma mansoni in an experimental model. The capacity of mouse peritoneal macrophages to ingest and kill Salmonella was assessed in mice infected with S. mansoni with or without concurrent Salmonella typhimurium infection. Schistosomiasis was associated with a significant decrease in the phagocytic index of macrophages, due to the reduced number of cells engaged in phagocytosis. However, the number of bacteria ingested by these cells was comparable to that of the control group. The bactericidal capacity of macrophages from S. mansoni-infected mice was also significantly lower than that of cells from normal mice. Macrophages from animals infected only with Salmonella typhimurium showed an increased phagocytic capacity. It was concluded that S. mansoni infection alters phagocytosis and intracellular destruction of salmonellae. This demonstration of a novel mechanism of survival of salmonellae represents a step forward in understanding the pathogenesis and management of chronic septicemic salmonellosis.
authors.affiliation: Departamento de Patologia, Faculdade de Ciencias da Saude, Universidade de Brasilia, Brazil.
authors.forename: M I
authors.initials: MI
authors.lastname: Muniz-Junqueira
authors.forename: A
authors.initials: A
authors.lastname: Prata
authors.forename: C E
authors.initials: CE
authors.lastname: Tosta
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001770:Blood Bactericidal Activity; D002908:Chronic Disease; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D010587:Phagocytosis; D012481:Salmonella Infections, Animal / Q000150:complications / Q000276:immunology; D012486:Salmonella typhimurium / Q000472:pathogenicity*; D012555:Schistosomiasis mansoni / Q000150:complications / Q000276:immunology*; D015163:Superinfection