Pharmacological studies on the new mucoactive agent (-)-6(S)-hydroxy-4(R)-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol .
The pharmacological activity and acute toxicity of (-)-6(S)-hydroxy-4(R)-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol (CO/1408, CAS 103079-06-7), a new mucoactive drug, were evaluated. After oral and intravenous administration CO/1408 increased the pulmonary secretion of fluorescein in rats, as an index of bronchosecretogogue activity. In addition, CO/1408 markedly increased the mucociliary transport rate. In in vitro study CO/1408 did not modify the viscosity of pig gastric mucin. Acute toxicity studies showed a very low toxicity after single dose indicating a high safety level for the doses used in this report. The results obtained point out the potential usefulness of CO/1408 to ameliorate the symptoms observed in some obstructive pulmonary diseases.
Zuccari
G
G
Research and Development Laboratories, Camillo Corvi S.p.A., Piacenza, Italy.
Brandolini
L
L
Clavenna
G
G
Fantini
P L
PL
D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D010856:Columbidae; D003511:Cyclohexanols / Q000494:pharmacology* / Q000633:toxicity; D053138:Cyclohexenes; D005100:Expectorants / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009077:Mucins / Q000378:metabolism; D009079:Mucociliary Clearance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism; D013552:Swine; D014783:Viscosity
D003511:Cyclohexanols; D053138:Cyclohexenes; D005100:Expectorants; D009077:Mucins; C065237:6-hydroxy-4-(1-hydroxy-1-methylethyl)-1-cyclohexene-1-ethanol; D000111:Acetylcysteine