title: Anti-inflammatory effects of vitamin E on experimental lens-induced uveitis.
abstract: The anti-phlogistic effect of dietary vitamin E supplementation on the acute inflammation observed in experimental lens-induced uveitis in Brown Norway rats was studied. The effects of vitamin E were examined using histopathologic parameters as well as by measuring the levels of arachidonic acid metabolites. Histologic examination of the eyes revealed that the vitamin E-deficient animals had the most severe destruction of the retina, while those animals receiving the vitamin E-supplemented diet exhibited the best preservation of the retinal architecture. Levels of arachidonic acid metabolites, as determined by radioimmunoassay, were significantly higher in vitamin E deficient rats as compared with rats on a normal diet.
authors.affiliation: Doheny Eye Institute, Los Angeles, CA.
authors.forename: L
authors.initials: L
authors.lastname: Cid
authors.forename: G
authors.initials: G
authors.lastname: Pararajasegaram
authors.forename: A
authors.initials: A
authors.lastname: Sevanian
authors.forename: W
authors.initials: W
authors.lastname: Gauderman
authors.forename: J L
authors.initials: JL
authors.lastname: Romero
authors.forename: G E
authors.initials: GE
authors.lastname: Marak
authors.forename: N A
authors.initials: NA
authors.lastname: Rao
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000032:analysis; D002829:Choroid / Q000737:chemistry / Q000473:pathology; D003459:Crystallins / Q000032:analysis; D005260:Female; D011863:Radioimmunoassay; D051381:Rats; D011914:Rats, Inbred BN; D014605:Uveitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003459:Crystallins; D014810:Vitamin E; D016718:Arachidonic Acid