title: Effect of combined deficiency of fat and vitamin A on N-nitrosodiethylamine-induced lung carcinogenesis in mice.
abstract: The present investigation shows the effect of combined dietary deprivation of fat and vitamin A on N-nitrosodiethylamine (NDEA) induced lung carcinogenesis in male Swiss NMRI mice. Lung tumors were induced by three intragastric administrations of NDEA (80, 80, 40, mg/kg body wt.) in normal saline with a gap of 4 weeks between each administration. The tumor incidence and tumor burden in control animals were found to be 39.1 and 3.9%, respectively. Fat deficiency decreased the tumor incidence to 30.4% and tumor burden to 3.7%. On the other hand, vitamin A deficiency increased them to 95.6 and 6.8%, respectively. Fat deprivation in the diet of animals fed with vitamin A deficient diet decreased the tumor burden and tumor incidence to 59.0 and 4.0%, respectively which were still more than in the control animals. This study suggests a protective role for low intake of fat in vitamin A deficiency.
authors.affiliation: Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: K L
authors.initials: KL
authors.lastname: Khanduja
authors.forename: I B
authors.initials: IB
authors.lastname: Koul
authors.forename: R K
authors.initials: RK
authors.lastname: Gandhi
authors.forename: S
authors.initials: S
authors.lastname: Sehgal
authors.forename: R R
authors.initials: RR
authors.lastname: Sharma
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000378:metabolism*; D004052:Diethylnitrosamine; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014801:Vitamin A / Q000378:metabolism; D014802:Vitamin A Deficiency / Q000150:complications*
chemical_list: D004041:Dietary Fats; D014801:Vitamin A; D004052:Diethylnitrosamine