title: Correlation of urine protein/creatinine ratio and twenty-four-hour urinary protein excretion in normal cats and cats with surgically induced chronic renal failure.
abstract: Urine protein/creatinine (UP/C) ratios and 24-hour urinary protein excretion were compared in clinically normal cats and cats with surgically induced chronic renal failure (CRF). Mean 24-hour urinary protein excretion in 30 clinically normal cats fed a 28% protein diet (dry weight basis) was 4.93 mg/kg/24-hour (SD = 1.34) with a range of 2.99 to 8.88. Mean UP/C ratio in these cats was 0.134 (SD = 0.037) with a range of 0.073 to 0.239. Mean 24-hour urinary protein excretion in CRF cats was 10.49 mg/kg/24-hour (SD = 11.28) with a range of 2.16 to 62.93. Mean UP/C ratio in the CRF cats was 0.359 (SD = 0.374) with a range of 0.061 to 1.916. Linear regression showed high correlation (R2 = 0.973, P less than 0.001) between 24-hour urinary protein excretion and UP/C ratio in clinically normal cats and cats with surgically induced chronic renal failure. The regression equation for 24-hour urinary protein excretion versus UP/C ratio was: 24-hour urinary protein excretion = 29.39 (UP/C) + 0.18. Results of this study indicate that UP/C ratios are a valid estimate of 24-hour urinary protein excretion in clinically normal and CRF cats. Dietary protein intake significantly affected UP/C ratios in clinically normal cats and cats with surgically induced CRF. Therefore, the influence of dietary protein should be considered when interpreting UP/C ratios.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul.
authors.forename: L G
authors.initials: LG
authors.lastname: Adams
authors.forename: D J
authors.initials: DJ
authors.lastname: Polzin
authors.forename: C A
authors.initials: CA
authors.lastname: Osborne
authors.forename: T D
authors.initials: TD
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000652:urine*; D002415:Cats; D003404:Creatinine / Q000652:urine*; D005260:Female; D007676:Kidney Failure, Chronic / Q000652:urine / Q000662:veterinary*; D011507:Proteinuria / Q000652:urine / Q000662:veterinary*; D012044:Regression Analysis
chemical_list: D003404:Creatinine