title: Mapping of the human VLA-alpha 4 gene to chromosome 2q31-q32.
abstract: The integrin VLA-4 (alpha 4: beta 1; CD49d/CD29) is involved in both cellular adhesion to extracellular matrix and cell-cell interactions. We have determined that the human gene coding for VLA-alpha 4 is located on the long arm of chromosome 2 by using fluorescence in situ hybridization. The VLA-alpha 4 gene has been more precisely mapped to the 2q31-q32 region after GTG banding (G-bands by trypsin using Giemsa). These data suggest that the VLA-4 gene belongs to the COL3A1-(ELN-FN)-COL6A3 linkage group and establishes a potential genetic relationship between the alpha 4 and alpha v integrin subunits.
authors.affiliation: Servicio de Inmunologia, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Fernández-Ruiz
authors.forename: F
authors.initials: F
authors.lastname: Pardo-Manuel de Villena
authors.forename: M A
authors.initials: MA
authors.lastname: Rubio
authors.forename: A L
authors.initials: AL
authors.lastname: Corbí
authors.forename: S
authors.initials: S
authors.lastname: Rodriguez de Córdoba
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-Madrid
mesh_terms: D002448:Cell Adhesion; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D039001:Integrin alpha Chains; D008856:Microscopy, Fluorescence; D009693:Nucleic Acid Hybridization; D016029:Receptors, Very Late Antigen / Q000235:genetics*
chemical_list: C063493:CDw49d; D039001:Integrin alpha Chains; D016029:Receptors, Very Late Antigen