Effect of L-threo-3, 4-dihydroxyphenylserine on orthostatic hypotension in a patient with spinal cord injury.
A 72-year-old female who underwent the extirpation of metastatic intraspinal tumor showed an extremely wide variation of blood pressure with recurrent episodes of syncope due to paroxysmal hypotension. Treatment of the patient with salt supplement and L-threo-3, 4-dihydroxyphenylserine, an exogenous precursor of norepinephrine, markedly improved the syncopal attack as well as the daily activity.
Muneta
S
S
Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
Iwata
T
T
Hiwada
K
K
Murakami
E
E
Sato
Y
Y
Imamura
Y
Y
D000230:Adenocarcinoma / Q000150:complications / Q000556:secondary / Q000601:surgery; D000368:Aged; D001794:Blood Pressure; D015103:Droxidopa / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate; D006801:Humans; D007024:Hypotension, Orthostatic / Q000188:drug therapy* / Q000209:etiology; D009638:Norepinephrine / Q000627:therapeutic use; D012083:Renin / Q000097:blood; D013119:Spinal Cord Injuries / Q000150:complications*; D013125:Spinal Neoplasms / Q000150:complications / Q000556:secondary / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology
D012083:Renin; D015103:Droxidopa; D009638:Norepinephrine