title: Changes seen on magnetic resonance imaging in the intervertebral disc space after chemonucleolysis: a hypothesis concerning regeneration of the disc after chemonucleolysis.
abstract: Measurements of the intervertebral disc space were made by magnetic resonance imaging and plain film examinations over a period of 2 years in 26 patients who had undergone chemonucleolysis. The height of the posterior portion of the disc decreased after 3 months and never recovered; the height of the anterior portion also decreased but recovered slightly over the same period. The angle of lordosis and the range of motion in the treated segment were decreased, but recovered. Marked decrease in signal from the disc was observed after 2 weeks which did not recover till 2 years after chemonucleolysis. We suspect that the disc degenerated markedly after chemonucleolysis and changed into a type of scar tissue, maturation of which could stabilize the affected segment.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Nagoya University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Mimatsu
authors.forename: N
authors.initials: N
authors.lastname: Kawakami
authors.forename: T
authors.initials: T
authors.lastname: Miura
mesh_terms: D000293:Adolescent; D000328:Adult; D002358:Cartilage, Articular / Q000187:drug effects / Q000473:pathology; D002917:Chymopapain / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007403:Intervertebral Disc / Q000187:drug effects* / Q000473:pathology; D007404:Intervertebral Disc Chemolysis; D008159:Lumbar Vertebrae / Q000187:drug effects* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016059:Range of Motion, Articular / Q000187:drug effects; D012038:Regeneration / Q000187:drug effects*
chemical_list: D002917:Chymopapain