The roles of platelet-activating factor (PAF) in pulmonary vasoconstriction during venous air embolism in anesthetized mongrel dogs.
Chemical mediators play minor roles in the acute lung injury caused by venous air embolism. The function of PAF in this condition was examined. Eight open chest mongrel dogs, mechanically ventilated, received air at an infusion rate of 0.1 ml/kg per min for 15 min. In addition, four dogs received air under continuous infusion of PAF at 10 ng/kg per min, the other four dogs under pretreatment with the PAF antagonist, CV-3988, at 10 mg/kg. In conclusion, PAF did not mediate pulmonary vasoconstriction but did modulate it and might possibly modulate cardiac deterioration in air embolism.
Ohno
S
S
Department of Pulmonary Medicine, Jichi Medical School, Tochigi, Japan.
Suzuki
N
N
Kitamura
S
S
D000758:Anesthesia; D000818:Animals; D004285:Dogs; D004618:Embolism, Air / Q000503:physiopathology*; D008168:Lung / Q000098:blood supply*; D010972:Platelet Activating Factor / Q000502:physiology*; D014661:Vasoconstriction; D014680:Veins / Q000503:physiopathology*
D010972:Platelet Activating Factor