[Fatal varicella pneumonia unresponsive to acyclovir therapy in a child with a malignancy].
Acyclovir has become the drug of choice for prevention of visceral dissemination of Varicella-zoster virus infections in immunocompromised individuals. This article describes a 6-year-old girl taking cytotoxic therapy and radiotherapy for treatment of Hodgkin lymphoma who developed cutaneous varicella infection. Despite the early administration of acyclovir a fatal varicella pneumonia occurred and she died on the 4th day of hospitalization. Since the resistance is inducible, the increase of unresponsiveness to acyclovir in immunocompromised hosts with varicella infection is a potential risk that can cause to increase in fatalities in these patients.
Ceyhan
M
M
Dr. Hacettepe Universitesi Tip Fakültesi, Pediatrik Enfeksiyon Hastaliklari Unitesi.
Kanra
G
G
Seçmeer
G
G
Okuyan
K
K
Kale
G
G
D000212:Acyclovir / Q000627:therapeutic use*; D002644:Chickenpox / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000150:complications* / Q000628:therapy; D006801:Humans; D016867:Immunocompromised Host; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D011859:Radiography; D012307:Risk Factors; D016896:Treatment Outcome
D000212:Acyclovir
Malignansili bir çocukta acyclovir tedavisine cevap vermeyen fatal su çiçeği pnömonisi.