title: Poor prognosis acute myeloid leukaemia treated by matched unrelated donor marrow transplant without preceding total body irradiation.
abstract: Two patients with acute myeloid leukaemia, one in relapse after autologous bone marrow transplantation (BMT) (aged 52 years) and the other with primary resistant disease secondary to previously treated malignancy, have received marrow transplants from matched unrelated donors. Cytoreductive conditioning in both cases was with high-dose combination chemotherapy alone. Engraftment was aided by the administration of total lymphoid irradiation together with in vivo antilymphocyte antibody prior to marrow infusion. Both patients survive in complete remission, currently at 12 and 15 months post-BMT respectively. The avoidance of total body irradiation in BMT patients at high risk of early treatment-related mortality may be advantageous.
authors.affiliation: Department of Haematology, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK.
authors.forename: E J
authors.initials: EJ
authors.lastname: Kanfer
authors.forename: I
authors.initials: I
authors.lastname: Macdonald
authors.forename: G
authors.initials: G
authors.lastname: Hall
authors.forename: H
authors.initials: H
authors.lastname: Ward
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Evans
authors.forename: J
authors.initials: J
authors.lastname: Taylor
authors.forename: L
authors.initials: L
authors.lastname: Camba
authors.forename: M G
authors.initials: MG
authors.lastname: Glaser
authors.forename: D M
authors.initials: DM
authors.lastname: Samson
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000379:methods*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation