title: [Treatment of liver metastases from gastric cancer].
abstract: Nine patients with liver metastases from gastric cancer were treated in our department since 1986. Hepatectomy was performed in 3 cases and hepatic arterial infusion chemotherapy was performed in 6 cases. In 3 patients in whom hepatectomy was performed, the extent of liver metastases showed 2 H1 and 1 H2. One has survived for 20 months, but the other 2 died after 5 and 7 months, respectively. In 6 patients in whom hepatic arterial infusion chemotherapy was performed, the extent of liver metastases was H3. These patients were treated with 5-FU.EPIR.MMC (3 cases), CDDP.MMC (1 case), MMC only (1 case) and 5-FU.ADM.MMC.CDDP (1 case). This treatment revealed a 50% response rate (CR 1, PR 2). The patient with CR has survived for 6 years and 2 patients with PR died after 8 and 12 months. The patient with CR showed high AFP level (55, 480 ng/ml), and 2 patients with PR showed high AFP level (24, 327 ng/ml) or high CEA level (3,903 ng/ml). The prognosis of hepatectomy for liver metastases from gastric cancer was not so good. Hepatic arterial infusion chemotherapy seemed to be a useful treatment for liver metastases from gastric cancer.
authors.affiliation: Dept. of Surgery II, Shinshu University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Kajikawa
authors.forename: N
authors.initials: N
authors.lastname: Horigome
authors.forename: K
authors.initials: K
authors.lastname: Hanasaki
authors.forename: E
authors.initials: E
authors.lastname: Shiohara
authors.forename: Y
authors.initials: Y
authors.lastname: Haba
authors.forename: N
authors.initials: N
authors.lastname: Koide
authors.forename: S
authors.initials: S
authors.lastname: Koike
authors.forename: W
authors.initials: W
authors.lastname: Adachi
authors.forename: G
authors.initials: G
authors.lastname: Kaneko
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005743:Gastrectomy; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D015251:Epirubicin; D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil