Detrimental effect of hypotonic cromolyn sodium.
In a randomized, double-blind, placebo-controlled, crossover study, inhalation of the commercially available nebulized form of cromolyn sodium resulted in a significant decrease in forced midexpiratory flow rate between the 25th and 75th percentile points, equivalent to that observed for distilled water, in children with chronic asthma. We conclude that inhalation of the current hypotonic concentration of cromolyn sodium may be detrimental.
Chin
T W
TW
Department of Pediatrics, University of California, Irvine.
Nussbaum
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E
D000280:Administration, Inhalation; D000293:Adolescent; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D002648:Child; D004205:Cromolyn Sodium / Q000009:adverse effects*; D004311:Double-Blind Method; D006801:Humans; D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D008450:Maximal Midexpiratory Flow Rate / Q000187:drug effects; D012129:Respiratory Function Tests
D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D004205:Cromolyn Sodium