title: Pulmonary effects of body position, PEEP, and surfactant depletion in dogs.
abstract: The influence of position (sphinx, lateral, supine), surfactant depletion, and different positive end-expiratory pressure (PEEP) on functional residual capacity (FRC), series dead space (VdS) and compliance of the respiratory system (Crs) were evaluated in five dogs. Ventilation homogeneity as measured by an index (multiple breath alveolar mixing efficiency), oxygenation, and cardiovascular hemodynamics were additionally examined. The dogs were anesthetized with halothane, paralyzed, and mechanically ventilated. FRC and VdS were found to be notably large in dogs, 45 +/- 8 ml/kg and 6 +/- 1 ml/kg, respectively. FRC and ventilation homogeneity were improved in the sphinx position (prone position with upright head). Surfactant depletion by lung lavage with 37 degrees C saline caused an immediate and stable decrease in FRC, Crs, and oxygenation (P less than 0.05, respectively) for about 5 h without marked effects on the circulatory system. FRC and VdS increased with increasing PEEP. At the highest PEEP, 10 cmH2O (1 kPa), Crs decreased (P less than 0.05) and ventilation became more uneven, indicating alveolar overdistension.
authors.affiliation: Department of Anesthesiology, University of Texas Health Science Center, San Antonio.
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: J T
authors.initials: JT
authors.lastname: Gilbert
authors.forename: L
authors.initials: L
authors.lastname: Bunegin
authors.forename: J
authors.initials: J
authors.lastname: Gelineau
authors.forename: R B
authors.initials: RB
authors.lastname: Smith
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D005652:Functional Residual Capacity / Q000502:physiology; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology; D011175:Positive-Pressure Respiration; D011187:Posture; D011312:Pressure; D011659:Pulmonary Gas Exchange / Q000502:physiology; D011663:Pulmonary Surfactants / Q000502:physiology*; D012123:Pulmonary Ventilation / Q000502:physiology; D012119:Respiration / Q000502:physiology; D012126:Respiratory Dead Space / Q000502:physiology
chemical_list: D011663:Pulmonary Surfactants; D002245:Carbon Dioxide; D010100:Oxygen