Bioavailability to rats and toxicological potential in mice of bound residues of malathion in beans.
Under conditions of local practice, the application of 2,3-succinate-14C-malathion on beans led to the formation of 17-18% of bound 14C-residues after 30 weeks. When fed to rats, 75% of these residues became bioavailable after 2 days with the major part, excreted via expired air (8%) and urine (60%). The main radioactive metabolites detected in urine were malathion monocarboxylic acid and malathion dicarboxylic acid. Feeding of bound residues to mice (1.8 ppm in feed) for 90 days resulted in a reduction in body weight gain after 60 days and inhibition of erythrocyte cholinesterase activity after 90 days. Increased levels of serum glutamic oxaloacetic transaminase and alkaline phosphatase were also observed. The results strongly suggest that bean-bound malathion residues can cause adverse biological effects in mice.
Zayed
S M
SM
Middle Eastern Regional Radioisotope Centre for the Arab Countries, National Research Centre Dokki, Cairo, Egypt.
Farghaly
M
M
Mostafa
I Y
IY
D000469:Alkaline Phosphatase / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects / Q000378:metabolism; D001682:Biological Availability; D002250:Carbon Radioisotopes; D002802:Cholinesterases / Q000187:drug effects / Q000378:metabolism; D007887:Fabaceae; D005506:Food Contamination; D008294:Malathion / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D051379:Mice; D010573:Pesticide Residues / Q000493:pharmacokinetics / Q000633:toxicity*; D010946:Plants, Medicinal; D051381:Rats
D002250:Carbon Radioisotopes; D010573:Pesticide Residues; D001219:Aspartate Aminotransferases; D002802:Cholinesterases; D000469:Alkaline Phosphatase; D008294:Malathion