title: Long-term acid-base measurements in the fetal and maternal baboon.
abstract: OBJECTIVE
  The purpose of the study was to examine the relationship between maternal and fetal acid-base indexes in the baboon.
  
  
  METHODS
  Eight animals maintained in a tether system were studied during the third trimester. Results were analyzed using analysis of variance.
  
  
  RESULTS
  After recovery from surgery, pH in carotid artery blood of the fetus was 7.40 +/- 0.027 (mean +/- SD), PO2, 27.5 +/- 3.45 mm Hg; PCO2, 34.0 +/- 2.37 mm Hg; base deficit, 3.0 +/- 2.15 mEq/L; Hot, 33.4% +/- 2.69% and HbO2, 61.3% +/- 8.65%. The corresponding values in the mother were 7.48 +/- 0.035, 100.7 +/- 9.44 mm Hg, 26.4 +/- 2.95 mm Hg, 3.6 +/- 1.71 mEq/L, 32.6% +/- 4.0% and 97.9% +/- 1.28%, respectively. All indexes remained essentially the same until the onset of active labor, at which time the fetus became slightly acidotic and hypoxemic (pH less than 7.35, HbO2 less than 50%).
  
  
  CONCLUSIONS
  The baboon fetus has slightly higher pH2 and lower PaCO2 than the human fetus and PaO2, base deficit, and maternal-fetal gradients across the placenta in these two primate species are comparable.
authors.affiliation: Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
authors.forename: S S
authors.initials: SS
authors.lastname: Daniel
authors.forename: L S
authors.initials: LS
authors.lastname: James
authors.forename: G
authors.initials: G
authors.lastname: MacCarter
authors.forename: H O
authors.initials: HO
authors.lastname: Morishima
authors.forename: R I
authors.initials: RI
authors.lastname: Stark
mesh_terms: D000136:Acid-Base Equilibrium; D000704:Analysis of Variance; D000818:Animals; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010215:Papio; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen