title: Quantitative dependence of MR signal intensity on tissue concentration of Gd(HP-DO3A) in the nephrectomized rat.
abstract: Cardiac-gated SE 20/224 +/- 20 MR images were obtained from nephrectomized rats before and after intravenously administering 153Gd-Gd(HP-DO3A). The concentration of Gd, [Gd], was linear in dose in myocardium, skeletal muscle, and blood. Under steady-state conditions, where d[Gd]/dt = 0, image intensities (IIN) in regions of interest were compared with the measured [Gd]. IIN was linear in myocardium at less than or equal to 0.61 mumol/g-myocardium (less than or equal to 0.5 mmol/kg dose) and in skeletal muscle at less than or equal to 0.63 mumol/g-muscle (less than or equal to 0.75 mmol/kg). Above 0.6 mumol Gd/g-tissue, IIN did not increase further. The in vivo data were consistent with measured ex vivo and in vivo relaxivities. A 29% greater slope for IIN versus [Gd] in myocardium [14,439 +/- 4350 IIN (mumol/g)] than in muscle [10,258 +/- 5,296 IIN/(mumol/g)] was attributed to a significant difference in blood content: 25% versus 2% weight blood in myocardium and skeletal muscle, respectively. Two components were apparent from plots of ex vivo 1/T1 versus [Gd] in myocardium and muscle, and only one for blood.
authors.affiliation: Contrast Media Department, Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903-0191.
authors.forename: P
authors.initials: P
authors.lastname: Wedeking
authors.forename: C H
authors.initials: CH
authors.lastname: Sotak
authors.forename: J
authors.initials: J
authors.lastname: Telser
authors.forename: K
authors.initials: K
authors.lastname: Kumar
authors.forename: C A
authors.initials: CA
authors.lastname: Chang
authors.forename: M F
authors.initials: MF
authors.lastname: Tweedle
mesh_terms: D000818:Animals; D003287:Contrast Media; D005682:Gadolinium; D006321:Heart / Q000033:anatomy & histology; D006571:Heterocyclic Compounds; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009132:Muscles / Q000033:anatomy & histology; D009392:Nephrectomy; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium