title: Endometrium in in-vitro fertilization cycles: morphological and functional differentiation in the implantation phase.
abstract: Secretory differentiation of endometrium after multiple follicular stimulation using gonadotrophin releasing hormone and human menopausal gonadotrophin has been studied both histologically and immunohistochemically in 30 women undergoing in-vitro fertilization treatment. None had embryo transfer. Patients were randomly allocated to receive luteal phase support with a single dose of human chorionic gonadotrophin. The latter failed to produce any significant enhancement of endometrial structure or secretions. Appropriate glandular morphology was present in a greater proportion of those who were successfully stimulated than those who responded poorly. However, defective secretion of the cycle-dependent component studied, using monoclonal antibody D9B1, was demonstrated in two-thirds of cases regardless of the ovarian response. Early vascular maturation in the stroma was a common finding, and was thus considered as a feature of structural modulation of these endometria.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Manchester, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Seif
authors.forename: J M
authors.initials: JM
authors.lastname: Pearson
authors.forename: Z H
authors.initials: ZH
authors.lastname: Ibrahim
authors.forename: C H
authors.initials: CH
authors.lastname: Buckley
authors.forename: J D
authors.initials: JD
authors.lastname: Aplin
authors.forename: P
authors.initials: P
authors.lastname: Buck
authors.forename: P L
authors.initials: PL
authors.lastname: Matson
authors.forename: B A
authors.initials: BA
authors.lastname: Lieberman
mesh_terms: D000911:Antibodies, Monoclonal; D001706:Biopsy; D002064:Buserelin / Q000008:administration & dosage*; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D010064:Embryo Implantation; D004717:Endometrium / Q000033:anatomy & histology* / Q000187:drug effects; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007150:Immunohistochemistry; D007632:Keratan Sulfate / Q000032:analysis; D008596:Menotropins / Q000008:administration & dosage*; D011374:Progesterone / Q000097:blood
chemical_list: D000911:Antibodies, Monoclonal; D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins; D007632:Keratan Sulfate; D002064:Buserelin