Effects of phosphorus/calcium-restricted and phosphorus/calcium-replete 32% protein diets in dogs with chronic renal failure.
Twenty-four dogs with induced, severe chronic renal failure were allotted to 2 groups of 12 each. Group-A dogs were fed a 0.4% phosphorus (P)/0.6% calcium, 32% protein diet, and group-B dogs were fed a 1.4% P/1.9% calcium, 32% protein diet. Dogs were studied over 24 months to determine clinical status, survival, blood biochemical alterations, glomerular filtration rate (GFR), urinary excretion of P and protein, renal morphologic changes, and renal tissue concentrations of calcium, P, and magnesium. Group-A dogs developed statistically significant differences from group-B dogs in several blood biochemical values (PCV and total solids, calcium, P, potassium, sodium, chloride, total CO2 (TCO2), anion gap, and parathyroid hormone concentrations) and in urinary P excretion. Mean (+/- SEM) GFR values in group-A and group-B dogs were nearly identical when diets were initiated (group A = 0.73 +/- 0.05 ml/min/kg of body weight; group B = 0.72 +/- 0.08 ml/min/kg), but significantly (P = 0.0346) lower GFR developed in group-B than in group-A dogs over time. At 24 months, GFR in survivors was 0.83 +/- 0.08 and 0.63 +/- 0.15 ml/min/kg for dogs of groups A and B, respectively. Other measurements favored the hypothesis that P/calcium restriction was beneficial, but values failed to reach statistical significance. Survival was greater at 24 months in group-A than in group-B (7 vs 5) dogs, and renal tissue concentrations of calcium and P were higher in group-B than in group-A dogs. Differences were not detected between groups in urinary excretion of protein and in the type or severity of renal lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
Finco
D R
DR
Department of Physiology and Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Brown
S A
SA
Crowell
W A
WA
Groves
C A
CA
Duncan
J R
JR
Barsanti
J A
JA
D000136:Acid-Base Equilibrium; D000818:Animals; D001794:Blood Pressure; D002118:Calcium / Q000032:analysis / Q000097:blood; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000097:blood; D002712:Chlorides / Q000097:blood; D004044:Dietary Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000178:diet therapy*; D004285:Dogs; D004435:Eating; D005260:Female; D005919:Glomerular Filtration Rate; D006400:Hematocrit / Q000662:veterinary; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000178:diet therapy / Q000662:veterinary*; D008274:Magnesium / Q000032:analysis; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000032:analysis / Q000097:blood / Q000652:urine; D016226:Phosphorus, Dietary / Q000008:administration & dosage / Q000627:therapeutic use*; D012709:Serum Albumin / Q000032:analysis; D012964:Sodium / Q000097:blood
D002136:Calcium, Dietary; D002712:Chlorides; D004044:Dietary Proteins; D010281:Parathyroid Hormone; D016226:Phosphorus, Dietary; D012709:Serum Albumin; D002245:Carbon Dioxide; D010758:Phosphorus; D012964:Sodium; D008274:Magnesium; D002118:Calcium