title: Interactions between bacteria and influenza A virus in the development of influenza pneumonia.
abstract: Different proteases from various microorganisms present in the respiratory tract were capable of enhancing influenza virus infectivity and pathogenicity in mice by proteolytic activation of hemagglutinin (HA). Aerococcus viridans, isolated from a patient with pneumonia, secreted a protease that could activate HA directly, similarly to some Staphylococcus aureus strains. The protease of Pseudomonas aeruginosa could not activate HA directly, but combined application of P. aeruginosa protease and virus into mice enhanced virus titers and pathogenicity. Generation of trypsin-like activity in bronchoalveolar lavage fluids resulting from this combination treatment may be responsible for HA activation. A similar indirect effect on HA activation was induced by streptokinase and staphylokinase, which are known to generate plasmin by plasminogen activation. It was concluded that plasminogen-activating streptococci and staphylococci facilitate viral replication and pathogenicity of plasmin-sensitive influenza virus strains by amplification of the plasminogen/plasmin system.
authors.affiliation: Institut für Virologie Justus-Liebig-Universität, Giessen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Scheiblauer
authors.forename: M
authors.initials: M
authors.lastname: Reinacher
authors.forename: M
authors.initials: M
authors.lastname: Tashiro
authors.forename: R
authors.initials: R
authors.lastname: Rott
mesh_terms: D000818:Animals; D009980:Influenza A virus / Q000472:pathogenicity*; D008168:Lung / Q000382:microbiology; D051379:Mice; D008954:Models, Biological; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D010960:Plasminogen Activators / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D013289:Streptococcaceae / Q000472:pathogenicity; D014775:Virus Activation
chemical_list: D010960:Plasminogen Activators