title: Determination of glycyrrhizin and 18 alpha-, 18 beta-glycyrrhetinic acid in rat plasma by high-performance thin-layer chromatography.
abstract: An HPTLC method is described for the simultaneous determination of glycyrrhizinic acid tripotassium salt (3K-G), 18 alpha- and 18 beta-glycyrrhetinic acid (18 alpha-GA, 18 beta-GA) in rat plasma, after oral administration of 3K-G (30 mg/kg once a day for 30 days). Systolic pressure and the volume of urine excreted in 24 hours were recorded during this period to observe any drug-induced effects.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Modena, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vampa
authors.forename: S
authors.initials: S
authors.lastname: Benvenuti
authors.forename: T
authors.initials: T
authors.lastname: Rossi
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood* / Q000493:pharmacokinetics / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004231:Diuresis / Q000187:drug effects; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid