title: Taxonomical implications of the emergence of high frequency of occurrence of 2,4-diamino-6,7-diisopropylpteridine-resistant strains of Vibrio cholerae from clinical cases of cholera in Calcutta, India.
abstract: Of the 110 consecutive isolates of Vibrio cholerae recovered from cholera patients admitted to the Infectious Diseases Hospital, Calcutta, India, between July 1989 and October 1990, 90 and 82.7% were resistant to 10 and 150 micrograms of 2,4-diamino-6,7-diisopropylpteridine (O/129), respectively. Additionally, all O/129-resistant strains of V. cholerae were multiply resistant to antimicrobial agents. Except in the cases of four strains, resistance to O/129 was invariably linked with resistance to co-trimoxazole. Although O/129 susceptibility is still a useful test for Vibrio identification, resistance of V. cholerae to this compound in local areas might occasionally pose a problem.
authors.affiliation: National Institute of Cholera and Enteric Diseases, Calcutta, India.
authors.forename: T
authors.initials: T
authors.lastname: Ramamurthy
authors.forename: A
authors.initials: A
authors.lastname: Pal
authors.forename: S C
authors.initials: SC
authors.lastname: Pal
authors.forename: G B
authors.initials: GB
authors.lastname: Nair
mesh_terms: D002771:Cholera / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D006801:Humans; D007194:India; D011621:Pteridines / Q000494:pharmacology*; D012703:Serotyping; D014734:Vibrio cholerae / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D011621:Pteridines; C021594:O 129