A novel derivative of the prosthetic group heme d1: S-methylporphyrindione d1.
Several derivatives of heme d1 have been characterized by ultraviolet-visible, NMR, and mass spectrometry. Most arise from side reactions during the isolation of d1 from the enzyme. One, however, has now been shown to correspond to the replacement of a meso proton by an S-methyl group. Since the porphyrin is not exposed to S-methyl-containing reagents during its isolation, this raises hypotheses that it has its origin in vivo.
Timkovich
R
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Department of Chemistry, University of Alabama, Tuscaloosa 35487-0336.
Carlin
R T
RT
D002851:Chromatography, High Pressure Liquid; D003574:Cytochrome c Group; D003580:Cytochromes / Q000737:chemistry*; D006418:Heme / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008652:Mesoporphyrins / Q000737:chemistry / Q000302:isolation & purification*; D009572:Nitrite Reductases
D003574:Cytochrome c Group; D003580:Cytochromes; D008652:Mesoporphyrins; C073354:S-methylporphyrindione d1; D006418:Heme; C029400:heme d1; C019315:cytochrome cd1; D009572:Nitrite Reductases