title: Coordinated regulation of vascular endothelial cell growth and prostacyclin production by epidermal growth factor: evidence of clonal variations among rat aortic endothelial cells.
abstract: Rat aortic endothelial cells were found to exhibit clonal variations in response to EGF stimulation in cell growth and prostacyclin synthesis. EGF-induced growth and prostacyclin synthesis appeared to be regulated in a coordinated manner in that a clone with a higher response to EGF growth stimulation also exhibited a higher response to EGF-stimulated prostacyclin synthesis. This observation implies a possible involvement of prostacyclin synthesis in some of the biological effects of EGF on vascular endothelial cells.
authors.affiliation: Department of Physiology, Chang Gung Medical College, Taiwan, Rep. of China.
authors.forename: J K
authors.initials: JK
authors.lastname: Chen
authors.forename: Y T
authors.initials: YT
authors.lastname: Lau
authors.forename: J
authors.initials: J
authors.lastname: Chu
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000166:cytology*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis*; D051381:Rats; D011921:Rats, Inbred WKY; D013997:Time Factors
chemical_list: D004815:Epidermal Growth Factor; D011464:Epoprostenol