title: Differential cardiovascular effects of propranolol, atenolol, and pindolol measured by impedance cardiography.
abstract: We have evaluated Sramek's method of impedance cardiography as a non-invasive way of detecting the cardiovascular effects of drugs. We made cardiovascular measurements using the method during passive tilting and exercise 2 h after the oral administration of atenolol (50 and 100 mg), propranolol (40 and 80 mg), pindolol (5 and 10 mg), and placebo in seven separate studies involving eight healthy male volunteers. Equivalent doses of the pure antagonists atenolol (beta 1) and propranolol (beta 1, beta 2) produced similar reductions in heart rate, systolic blood pressure, and cardiac index, and increases in stroke volume and total peripheral resistance, particularly during exercise. In contrast the partial agonist pindolol produced increases in heart rate and cardiac index, and reductions in peripheral resistance at rest. During passive tilting and exercise pindolol reduced heart rate, but cardiac output and total peripheral resistance were unchanged except at the highest levels of exercise. The similar cardiovascular effects of atenolol and propranolol, but differing effects of pindolol, are consistent with reports using other methods of measurement. This suggests that impedance cardiography may have a place in the non-invasive assessment of the cardiovascular effects of drugs.
authors.affiliation: Division of Pharmacological Sciences and Toxicology, United Medical School, London, UK.
authors.forename: S H
authors.initials: SH
authors.lastname: Thomas
authors.forename: R C
authors.initials: RC
authors.lastname: Cooper
authors.forename: M
authors.initials: M
authors.lastname: Ekwuru
authors.forename: S
authors.initials: S
authors.lastname: Fletcher
authors.forename: J
authors.initials: J
authors.lastname: Gilbody
authors.forename: T S
authors.initials: TS
authors.lastname: Husseyin
authors.forename: M
authors.initials: M
authors.lastname: Ishaque
authors.forename: R
authors.initials: R
authors.lastname: Jagathesan
authors.forename: G
authors.initials: G
authors.lastname: Reddy
authors.forename: S E
authors.initials: SE
authors.lastname: Smith
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001262:Atenolol / Q000494:pharmacology*; D002307:Cardiography, Impedance / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D010869:Pindolol / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D012016:Reference Values
chemical_list: D001262:Atenolol; D011433:Propranolol; D010869:Pindolol