Kidney functioning during lithium treatment: a prospective study of patients treated with lithium for up to ten years.
A cohort of 53 patients with affective disorders who originally carried through renal functional tests before start of prophylactic lithium treatment were followed up prospectively after an average period of 8.5 years (range 7-10 years). Ten patients who had continued lithium treatment were re-examined. In this subgroup, the glomerular function was unaffected by the treatment, whereas the average urine volume increased during lithium treatment (NS). Polyuria and low renal concentrating abilities were also found before start of treatment and these findings underline the importance of access to renal baseline information prior to lithium treatment.
Povlsen
U J
UJ
Department of Psychiatry, Rigshospitalet, University of Copenhagen, Denmark.
Hetmar
O
O
Ladefoged
J
J
Bolwig
T G
TG
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D003404:Creatinine / Q000097:blood; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007677:Kidney Function Tests; D008094:Lithium / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D008094:Lithium; D003404:Creatinine