Cholinergic and adrenergic drugs affect delayed type hypersensitivity in C57BL/6 mice.
The present study examined the influence of systemic administration of neuroactive drugs on delayed-type hypersensitivity (DTH) in C57BL/6 mice. The cholinergic agonist nicotine and the acetylcholinesterase inhibitor physostigmine decreased DTH, whereas the alpha-adrenergic agonist clonidine stimulated DTH. In contrast isoprenaline, a specific beta-adrenergic agonist suppressed DTH. It is concluded from these observations that the autonomic nervous system modulates those processes governing DTH. It seems that the alpha-adrenergic subsystem stimulates, whereas the beta-adrenergic subsystem and the parasympathicus inhibit DTH.
Günther
B
B
Department of Animal Models, Institute of Microbiology and Experimental Therapy, Jena, Federal Republic of Germany.
Clausing
P
P
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D004334:Drug Administration Schedule; D006968:Hypersensitivity, Delayed / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000494:pharmacology*; D013566:Sympathomimetics / Q000008:administration & dosage / Q000494:pharmacology*
D010277:Parasympathomimetics; D013566:Sympathomimetics