New isoxazole derivatives of retinoids: synthesis and activity on growth and differentiation of tumor cells.
The effects of several newly synthesized isoxazole analogues of retinoids on differentiation and proliferation of 'in vitro' cultured tumor cell lines are reported. Some of the tested compounds exhibit significative differentiating action, inducing adipogenic conversion of the Chinese hamster FH06T1-1 cell line in a range of 2-10 times the activity of retinoic acid and retinol. In addition, most of the compound tested display antiproliferative activity comparable to that of natural retinoids. The reported data could be of interest for experimental anticancer therapy.
Simoni
D
D
Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Manfredini
S
S
Tabrizi
M A
MA
Bazzanini
R
R
Baraldi
P G
PG
Ferroni
R
R
Traniello
F
F
Nastruzzi
C
C
Feriotto
G
G
Gambari
R
R
D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D011905:Genes, ras / Q000502:physiology; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008168:Lung / Q000166:cytology; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D012176:Retinoids / Q000138:chemical synthesis / Q000494:pharmacology*; D014162:Transfection; D014407:Tumor Cells, Cultured / Q000187:drug effects
D007555:Isoxazoles; D012176:Retinoids