[Recovery of chronic hepatitis B- delta infection by zidovudine and recombinant interferon alpha combination therapy in a patient with Kaposi's sarcoma associated with HIV infection].
A 39 years old homosexual male suffering from chronic type B hepatitis superinfected by HDV, and positive for anti-HIV1 was treated with zidovudine associated with high doses of recombinant interferon alpha for onset of an extensive cutaneous Kaposi sarcoma. Other than the long-lasting disappearance of Kaposi's lesions, this therapy was followed by complete recovery from hepatitis B and D. Serological and hepatic clearance of both viruses was marked by two successive cytolytic peaks separated by a 9 month interval. The patient's immunologic status has remained stable at 30 months. To our knowledge, such a success had never been reported in the literature and the clearance of both hepatitis B and D viruses in an AIDS patient stands in sharp contrast with the usual rapidly progressive evolution of those triple coinfections. This phenomenon illustrates the potential benefits of zidovudine in association with high dose of interferon alpha in HIV patients suffering from hepatitis D.
Gaudin
J L
JL
Service d'Hépato-Gastroentérologie, Hôtel-Dieu, Lyon.
Causse
X
X
Zoulim
F
F
Chevallier
M
M
Trépo
C
C
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D004359:Drug Therapy, Combination; D006509:Hepatitis B / Q000150:complications / Q000628:therapy*; D003699:Hepatitis D / Q000150:complications / Q000628:therapy*; D006801:Humans; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications / Q000628:therapy; D011994:Recombinant Proteins; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000628:therapy; D012878:Skin Neoplasms / Q000209:etiology / Q000628:therapy; D015215:Zidovudine / Q000008:administration & dosage / Q000627:therapeutic use*
D007370:Interferon Type I; D011994:Recombinant Proteins; D015215:Zidovudine
Guérison d'une hépatite virale B-delta chronique par l'association zidovudine et interféron alpha recombinant chez un sujet ayant un sarcome de Kaposi associé au VIH.