title: Spatial control of the gap gene knirps in the Drosophila embryo by posterior morphogen system.
abstract: The gap genes of Drosophila are the first zygotic genes to respond to the maternal positional signals and establish the body pattern along the anterior-posterior axis. The gap gene knirps, required for patterning in the posterior region of the embryo, can be activated throughout the wild-type embryo and is normally repressed from the anterior and posterior sides. These results provide direct molecular evidence that the posterior morphogen system interacts in a fundamentally different manner than do hunchback and bicoid, which are responsible for anterior pattern formation.
authors.affiliation: Max-Planck Institut für Biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Göttingen, Germany.
authors.forename: M J
authors.initials: MJ
authors.lastname: Pankratz
authors.forename: M
authors.initials: M
authors.lastname: Busch
authors.forename: M
authors.initials: M
authors.lastname: Hoch
authors.forename: E
authors.initials: E
authors.lastname: Seifert
authors.forename: H
authors.initials: H
authors.lastname: Jäckle
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes; D008969:Molecular Sequence Data; D009024:Morphogenesis; D012045:Regulatory Sequences, Nucleic Acid