Filtering strategies in mass population screening for colorectal cancer: an economic evaluation.
On the basis of clinical trial data, 13 strategies for initial screening (filtering) for colorectal cancer are modeled for the purpose of economic evaluation. A wide range of detection cost estimates are generated, although ranking options by detection cost ignores the important consideration of undetected cancers. Formulating the problem as one of cost-effectiveness, however, allows the authors to demonstrate that members of a subset of strategies uniquely outperform all others and that the optimum strategy can be identified by the ex ante specification of the valuation of cancers missed on screening.
Walker
A
A
Department of Economics, University Hospital, University of Nottingham, England.
Whynes
D K
DK
D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D006801:Humans; D008403:Mass Screening / Q000191:economics* / Q000379:methods / Q000592:standards; D017059:Models, Econometric; D009780:Occult Blood; D010349:Patient Compliance; D015995:Prevalence; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires / Q000191:economics / Q000592:standards