Effect of anticancer drugs on the release of interleukin-6 in vitro.
This study investigates the effects of anticancer drugs and immunomodulating agents on the release of interleukin-6 (IL-6) from lipopolysaccharide-stimulated human peripheral blood mononuclear leucocytes in vitro. The addition of non-cytotoxic concentrations of Adriamycin (doxorubicin), vincristine and 4-OOH-cyclophosphamide (the in vitro active analogue of cyclophosphamide) resulted in suppression of IL-6 release. The drugs bleomycin, FK156 [D-lactoyl-L-alanyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl-(L)-g lycine], FK565 [heptanoyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl-(D)-alan ine] and the immunosuppressive agent cyclosporin A did not alter the release of IL-6 in the same experimental system.
Hasan
S I
SI
Royal College of Surgeons of England, London, UK.
Blaney
B A
BA
Turk
J L
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000378:metabolism*; D051379:Mice; D012636:Secretory Rate / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D015850:Interleukin-6; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide