Comparative study of tilidine-naloxone and pentazocine in knee and hip osteoarthritis.
Fifty patients, twenty-five suffering from severe knee osteoarthritis and twenty-five from acute hip osteoarthritis, received pentazocine or a new preparation of tilidine-naloxone for a period of 2 weeks, in a double-blind study. The two drugs were found to have the same efficacy and tolerance in both diseases with a minor but not statistically significant superiority for tilidine-naloxone. Similar quantities of drugs were taken over the study period, while patients were allowed to take as many as 8 capsules per day to relieve pain. There were quite equivalent side-effects and no marked changes in laboratory tests.
Van Cauwenberge
H
H
Department of Internal Medicine, Centre Hospitalier Universitaire Sart-Tilman, Liège, Belgium.
Ruhwiedel
M
M
Albert
A
A
Franchimont
P
P
D000368:Aged; D004311:Double-Blind Method; D004338:Drug Combinations; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000009:adverse effects / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy*; D015207:Osteoarthritis, Hip / Q000188:drug therapy*; D010423:Pentazocine / Q000009:adverse effects / Q000627:therapeutic use*; D013993:Tilidine / Q000009:adverse effects / Q000627:therapeutic use*
D004338:Drug Combinations; D009270:Naloxone; D013993:Tilidine; D010423:Pentazocine