SV40 small t deletion mutants preferentially transform mononuclear phagocytes and B lymphocytes in vivo.
Hamsters injected intracardiacally with wild-type SV40 developed diverse tumors, with no one type predominating. However, hamsters injected with small t deletion mutants of SV40 uniformly developed true histiocytic or B-cell lymphomas, both of which arise from rapidly dividing cell populations, with very few tumors of other types. Our results are consistent with in vitro studies which suggest a requirement for the small t function in SV40 transformation of nondividing cells.
Cicala
C
C
Section on Viruses and Cellular Biology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
Pompetti
F
F
Nguyen
P
P
Dixon
K
K
Levine
A S
AS
Carbone
M
M
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D001402:B-Lymphocytes / Q000382:microbiology*; D002472:Cell Transformation, Viral; D006224:Cricetinae; D008223:Lymphoma / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000382:microbiology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000382:microbiology / Q000473:pathology; D008647:Mesocricetus; D008654:Mesothelioma / Q000473:pathology; D016296:Mutagenesis; D012516:Osteosarcoma / Q000473:pathology; D010586:Phagocytes / Q000382:microbiology*
D000952:Antigens, Polyomavirus Transforming