[The effect of ionizing radiation on the Ca2+, Mg2(+)-ATPase activity of plasma membranes].
A study was made of a change in Ca2+, Mg(2+)-ATPase activity induced by the effect of ionizing radiation (5-10(4) Gy) on a thymocyte plasma membrane suspension. The Michaelis' constant and maximum rate of enzymic reactions were determined. With a dose of 10(3) Gy the structural changes in Ca2+, Mg(2+)-ATPase were shown to reduce the affinity of the substrate to an active enzyme center and to decrease the rate of the enzyme/substrate complex degradation.
Dreval'
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D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism / Q000528:radiation effects*; D000252:Calcium-Transporting ATPases / Q000378:metabolism / Q000528:radiation effects*; D002417:Cattle; D002462:Cell Membrane / Q000201:enzymology / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D066298:In Vitro Techniques; D010315:Particle Accelerators; D013379:Substrate Specificity / Q000528:radiation effects; D013950:Thymus Gland / Q000201:enzymology / Q000528:radiation effects
D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases
Vliianie ioniziruiushchego izlucheniia na aktivnost' Ca2+, Mg2(+)-ATFazy plazmaticheskikh membran.