title: Abnormal uptake of technetium-99m hexakis-2-methoxyisobutylisonitrile in a primary cardiac lymphoma.
abstract: Abnormally high uptake of technetium-99m hexakis-2-methoxyisobutylisonitrile (99mTc-SESTAMIBI) in the right ventricle and in the septum was observed in a 47-year-old woman initially presenting with dysarthria and left hemiparesis. Endomyocardial biopsy demonstrated a high-grade malignant non-Hodgkin's lymphoma. Complete remission was achieved by combined cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy and radiotherapy of the heart and mediastinum. The post-remission single photon emission tomography (SPET) 99mTc-SESTAMIBI study showed a homogeneous distribution pattern, in agreement with echocardiography computed tomography and magnetic resonance imaging. Increased uptake of 99mTc-SESTAMIBI, a myocardial perfusion agent, has been observed in some benign and malignant tumours. It may prove to be useful in the diagnosis and follow-up of malignancies.
authors.affiliation: Department of Nuclear Medicine, Ospedali Riuniti di Bergamo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Medolago
authors.forename: G
authors.initials: G
authors.lastname: Virotta
authors.forename: A
authors.initials: A
authors.lastname: Pitì
authors.forename: M
authors.initials: M
authors.lastname: Tespili
authors.forename: F
authors.initials: F
authors.lastname: D'Adda
authors.forename: M R
authors.initials: MR
authors.lastname: Rottoli
authors.forename: B
authors.initials: B
authors.lastname: Comotti
authors.forename: T
authors.initials: T
authors.lastname: Motta
authors.forename: C
authors.initials: C
authors.lastname: Orlandi
authors.forename: C
authors.initials: C
authors.lastname: Bertocchi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006338:Heart Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000532:radiotherapy; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011241:Prednisone / Q000008:administration & dosage; D011877:Radionuclide Imaging; D012074:Remission Induction; D017256:Technetium Tc 99m Sestamibi; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015609:Organotechnetium Compounds; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D017256:Technetium Tc 99m Sestamibi; D011241:Prednisone