[No improvement of joint cartilage healing after trauma by the administration of insulin-like growth factor I, epidermal growth factor and fibroblast growth factor in rabbits].
Insulin-like growth factor I (Somatomedin C), epidermal growth factor, and fibroblast growth factor exert a stimulatory effect on articular chondrocyte metabolism in vitro. We studied the effect of these peptides on the repair of standardized full-thickness articular cartilage defects in the knee-joints of 32 young adult rabbits. In our in vivo study, the growth factors failed to stimulate cartilage cell replication, chondrocyte proteoglycan synthesis or defect filling. The trauma, however, had a significant stimulatory effect on the mitotic activity of the chondrocytes near the defect, but not on the synthesis of sulfated proteoglycans.
Neidel
J J
JJ
Klinik und Poliklinik für Orthopädie, Universität zu Köln.
D000818:Animals; D001345:Autoradiography; D002358:Cartilage, Articular / Q000187:drug effects / Q000293:injuries*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006133:Growth Substances / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D006133:Growth Substances; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D007334:Insulin-Like Growth Factor I
Keine Verbesserung der Gelenkknorpelheilung nach Trauma durch intraarticuläre Gabe von insulinartigem Wachstumsfaktor I, epidermalem Wachstumsfaktor und Fibroblasten-Wachstumsfaktor beim Kaninchen.