Mechanisms of induction of tolerance to syngeneic IgE.
We have previously shown that T cell tolerance to syngeneic IgE in mice is delayed after birth for 2-3 weeks and is induced concurrently with the appearance of IgE in serum. Although inoculation of IgE in saline on the day of birth caused T cell tolerance, an apparent inconsistency was our inability to tolerize mice after day 2, despite evidence indicating that endogenously-produced IgE is effective at the age of 2-3 weeks. Data presented here indicate that repeated i.p. inoculations, during this period, of smaller doses of IgE in saline induce tolerance in many individual mice, thus mimicking to a degree the naturally occurring events. Another earlier finding was that normal adult B cells, but not T cells, can tolerize T cells to IgE when administered on the day of birth. We have now observed that B cells bearing surface IgE are much more tolerogenic than the remaining B cells.
Haba
S
S
Department of Biology, Brandeis University, Waltham, MA 02254.
Nisonoff
A
A
D000818:Animals; D000831:Animals, Newborn; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000008:administration & dosage / Q000097:blood / Q000302:isolation & purification; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology; D014461:Ultracentrifugation
D000888:Antibodies, Anti-Idiotypic; D007073:Immunoglobulin E