Cycloid psychosis: regional cerebral blood flow correlates of a psychotic episode.
Eight patients meeting Leonhard's criteria for cycloid psychosis were investigated on repeated occasions during a psychotic episode, with regional cerebral blood flow measurements and clinical ratings. The results showed that, at admission to the hospital, when the patients were clinically exacerbated, the mean hemispheric blood flow was significantly elevated compared with values from a normal control group. The hemispheric blood flow level covaried significantly with the degree of clinical symptoms, such that the more elevated the cortical blood flow was, the more behaviorally disturbed was the patient. At discharge from the hospital, the patients had no residual symptoms and the cortical blood flow was normal. These findings differ distinctly from those commonly made in other psychoses, such as schizophrenia.
Warkentin
S
S
Department of Psychiatry, University of Lund, Sweden.
Nilsson
A
A
Karlson
S
S
Risberg
J
J
Franze'n
G
G
Gustafson
L
L
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000523:psychology; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply*; D002746:Chlorpromazine / Q000008:administration & dosage; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004359:Drug Therapy, Combination; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010546:Perphenazine / Q000008:administration & dosage; D011618:Psychotic Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000523:psychology; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D013881:Thioridazine / Q000008:administration & dosage
D010546:Perphenazine; D006220:Haloperidol; D013881:Thioridazine; D002746:Chlorpromazine