[Significance of vitamin K (VK) administration in patients under chemotherapy during postoperative fasting period].
Recently coagulopathy caused by vitamin K (VK) deficiency following antibiotic therapy in malnourished patients has been reported. We studied on the same problem particularly in patients under chemotherapy during postoperative fasting period. For this purpose, prothrombin time (PT), vitamin K-dependent coagulation factors (Factor II (F-II), VII (F-VII) and protein C), PIVKA-II (PK-II) and plasma level of VK in two groups of patients with or without VK administration were measured in esophageal cancer patients. In the group with VK, VK2 were given intravenously everyday. In the group without VK, PT prolonged and F-II decreased from the seventh postoperative day, especially on the 14th day significantly. Although F-VII and protein C decreased on the first day and returned subsequently on the seventh day, no significance was observed between two groups. PK-II increased clearly in the group without VK from the seventh day, whereas no significant changes were observed in the group with VK. The plasma level of VK1 decreased in both groups, but VK2, especially MK-4, was high in the group with VK.
Ojiro
M
M
First Department of Surgery, School of Medicine, Kagoshima University, Japan.
Takenoshita
M
M
Toshinaga
T
T
Shimazu
H
H
D000970:Antineoplastic Agents / Q000627:therapeutic use; D015415:Biomarkers; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000601:surgery; D005167:Factor VII / Q000032:analysis; D005215:Fasting; D006801:Humans; D011184:Postoperative Period; D011486:Protein C / Q000032:analysis; D011498:Protein Precursors / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D014812:Vitamin K / Q000008:administration & dosage* / Q000097:blood
D000970:Antineoplastic Agents; D015415:Biomarkers; D011486:Protein C; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D005167:Factor VII; D011516:Prothrombin