title: Minimum alveolar concentration of sevoflurane in children.
abstract: We have determined the minimum alveolar concentration (MAC) value of sevoflurane in 20 children, of both sexes, aged 3-5 yr. MAC was found to be 2.49 (SE 0.08)%, which was greater than that of adults in our previous study. The ratio of MAC values between children and adults is similar to that reported elsewhere for enflurane and isoflurane, but not for halothane. The anaesthetic ED95 that prevented 95% of patients from moving was 2.88%.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Hamamatsu University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Katoh
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
mesh_terms: D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000493:pharmacokinetics*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004987:Ethers / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D011650:Pulmonary Alveoli / Q000378:metabolism*; D000077149:Sevoflurane; D013990:Tidal Volume
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane