title: Chondrodiatasis in rabbits: a study of the effect of transphyseal bone lengthening on cell division, synthetic function, and microcirculation in the growth plate.
abstract: The effects of chondrodiatasis on chondrocyte division, matrix synthesis, and microcirculation in rabbit growth plate were studied. The procedure did not produce any significant change in the percentage of cells labeled with tritiated thymidine, the intensity of radioactive sulfate labeling of the matrix, or the blood supply of the physis. These findings suggest that the procedure does not work by stimulating cell division, synthetic function, or vascularity of the plate, but rather by stretching the matrix passively.
authors.affiliation: Pediatric Orthopaedic Unit, Massachusetts General Hospital, Boston 02114.
authors.forename: E B
authors.initials: EB
authors.lastname: Elmer
authors.forename: M G
authors.initials: MG
authors.lastname: Ehrlich
authors.forename: D J
authors.initials: DJ
authors.lastname: Zaleske
authors.forename: C
authors.initials: C
authors.lastname: Polsky
authors.forename: H J
authors.initials: HJ
authors.lastname: Mankin
mesh_terms: D000818:Animals; D001345:Autoradiography; D001852:Bone Lengthening; D001857:Bone Matrix / Q000254:growth & development / Q000378:metabolism*; D001858:Bone Nails; D002356:Cartilage / Q000166:cytology*; D002455:Cell Division; D005269:Femur / Q000254:growth & development; D006132:Growth Plate / Q000098:blood supply / Q000502:physiology*; D008833:Microcirculation; D011817:Rabbits; D013997:Time Factors