[Study of DDS to the lymph node-metastases of the gastric cancer by the endoscopic injection of Lip-ADM].
We studied the drug delivery and anti-tumor effect of the endoscopic injection of liposomal adriamycin (Lip-ADM) in the submucosa of stomach by rabbit model. Concerning the drug delivery to regional lymphnode, the lymphnode ADM concentration of Lip-ADM injection group was higher than that of free ADM group (p less than 0.05). We also studied the lymphnodes pathohistologically. The lymphnodes of the rabbits injected with Lip-ADM indicated massive necrosis, whereas those of the rabbits injected with free ADM indicated residual tumor. Among clinical cases, patients injected Lip-ADM had paraaortic lymphnodes in which the adriamycin remained 10 days. The endoscopic injection of Lip-ADM into the submucosa of the stomach appeared to be an effective drug delivery system.
Hirahata
S
S
Dept. of Surgery, Ashikaga Red Cross Hospital.
Kumai
K
K
Ishibiki
K
K
Kitajima
M
M
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005773:Gastroscopy; D015552:Injections, Intralesional; D008081:Liposomes; D008198:Lymph Nodes / Q000378:metabolism*; D008207:Lymphatic Metastasis / Q000473:pathology*; D011817:Rabbits; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*
D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin