title: A novel derivative of the prosthetic group heme d1: S-methylporphyrindione d1.
abstract: Several derivatives of heme d1 have been characterized by ultraviolet-visible, NMR, and mass spectrometry. Most arise from side reactions during the isolation of d1 from the enzyme. One, however, has now been shown to correspond to the replacement of a meso proton by an S-methyl group. Since the porphyrin is not exposed to S-methyl-containing reagents during its isolation, this raises hypotheses that it has its origin in vivo.
authors.affiliation: Department of Chemistry, University of Alabama, Tuscaloosa 35487-0336.
authors.forename: R
authors.initials: R
authors.lastname: Timkovich
authors.forename: R T
authors.initials: RT
authors.lastname: Carlin
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003574:Cytochrome c Group; D003580:Cytochromes / Q000737:chemistry*; D006418:Heme / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008652:Mesoporphyrins / Q000737:chemistry / Q000302:isolation & purification*; D009572:Nitrite Reductases
chemical_list: D003574:Cytochrome c Group; D003580:Cytochromes; D008652:Mesoporphyrins; C073354:S-methylporphyrindione d1; D006418:Heme; C029400:heme d1; C019315:cytochrome cd1; D009572:Nitrite Reductases