title: The identity of IgE receptors (Fc epsilon RII) that mediate cellular activation of human macrophages: evidence against a role for CD23.
abstract: There is now compelling evidence that macrophages bind IgE, and are involved in several IgE-dependent responses. The CD23 antigen mediates a mitogenic response in "primed" B-lymphocytes, although its expression is not confined to B cells, and CD23 is inducably expressed in many cells including macrophages. CD23 is also known to bind IgE, a property that leads to inhibition of the mitogenic response in B cells. In the present review, the possibility that CD23 mediates IgE-dependent responses in macrophages has been re-examined, and it is proposed that the functional receptor for IgE on macrophages may be quite separate from the CD23 antigen.
authors.affiliation: Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, U.K.
authors.forename: J
authors.initials: J
authors.lastname: MacDermot
authors.forename: S
authors.initials: S
authors.lastname: Joseph
authors.forename: C T
authors.initials: CT
authors.lastname: Dollery
mesh_terms: D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology*; D001402:B-Lymphocytes / Q000502:physiology; D002460:Cell Line; D006801:Humans; D066298:In Vitro Techniques; D015847:Interleukin-4 / Q000502:physiology; D008262:Macrophage Activation; D008264:Macrophages / Q000502:physiology*; D011961:Receptors, Fc / Q000502:physiology*; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000502:physiology; D015398:Signal Transduction; D013929:Thromboxane B2 / Q000378:metabolism
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D015847:Interleukin-4; D013929:Thromboxane B2