Clinical response of nasal adenocarcinoma to cisplatin chemotherapy in 11 dogs.
In 11 dogs with nasal adenocarcinoma, IV treatment with 2 to 8 cycles of cisplatin at a dosage of 60 mg/m2 of body surface, given at 3-week intervals, resulted in a survival time of 8 to 128 weeks (mean, 32.7 weeks; median, 20 weeks). Radiography revealed complete remission in 2 dogs and partial remission in 1 dog, for an overall response rate of 27%. Clinical problems such as nasal discharge (n = 11), sneezing (n = 6), and epistaxis (n = 4) resolved in 1 to 2 weeks in all dogs after beginning chemotherapy.
Hahn
K A
KA
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-7403.
Knapp
D W
DW
Richardson
R C
RC
Matlock
C L
CL
D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004285:Dogs; D009669:Nose Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed / Q000662:veterinary
D002945:Cisplatin