Central nervous system stimulants as symptomatic treatments for AIDS-related neuropsychiatric impairment.
Seven patients with AIDS-related cognitive and emotional deficits had neuropsychologic testing and then were treated with methylphenidate or dextroamphetamine in individualized doses. Three patients showed marked functional improvement and 5 of the 7 became more spontaneous, reactive, and animated. Additional neuropsychologic testing showed statistically significant improvement in a subset of tests; however, scores did not return to baseline in tests done after the treatment was discontinued for 1-3 days.
Angrist
B
B
New York DVA Medical Center, NY 10010.
d'Hollosy
M
M
Sanfilipo
M
M
Satriano
J
J
Diamond
G
G
Simberkoff
M
M
Weinreb
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000523:psychology; D000328:Adult; D003913:Dextroamphetamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D008774:Methylphenidate / Q000627:therapeutic use*; D008875:Middle Aged; D009483:Neuropsychological Tests; D016037:Single-Blind Method
D008774:Methylphenidate; D003913:Dextroamphetamine