title: The effect of anabolic steroids on the biomechanical and histological properties of rat tendon.
abstract: Twenty-four male rats were divided into four groups, with anabolic steroids and exercise as variables. Biomechanical tests and histological evaluations were performed. The results of the biomechanical tests suggested that anabolic steroids produce a stiffer tendon, which fails with less elongation. The energy at the time when the tendon failed, the toe-limit elongation, and the elongation at the time of the first failure were all affected significantly. Changes in the force at failure were not statistically significant. No alterations of structure were noted when the specimens were viewed with light microscopy. Alterations of the sizes of the collagen fibrils were noted on electron microscopy.
authors.affiliation: University of Oklahoma Health Sciences Center, Oklahoma City.
authors.forename: J W
authors.initials: JW
authors.lastname: Miles
authors.forename: W A
authors.initials: WA
authors.lastname: Grana
authors.forename: D
authors.initials: D
authors.lastname: Egle
authors.forename: K W
authors.initials: KW
authors.lastname: Min
authors.forename: J
authors.initials: J
authors.lastname: Chitwood
mesh_terms: D045930:Anabolic Agents / Q000633:toxicity*; D000704:Analysis of Variance; D000818:Animals; D001696:Biomechanical Phenomena; D003094:Collagen / Q000648:ultrastructure; D004548:Elasticity; D016018:Least-Squares Analysis; D016014:Linear Models; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives / Q000633:toxicity; D000077603:Nandrolone Decanoate; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013197:Stanozolol / Q000633:toxicity; D013314:Stress, Mechanical; D013499:Surface Properties; D013710:Tendons / Q000187:drug effects* / Q000648:ultrastructure; D013718:Tensile Strength
chemical_list: D045930:Anabolic Agents; D013197:Stanozolol; D009277:Nandrolone; D003094:Collagen; D000077603:Nandrolone Decanoate