Inorganic fluoride in prolonged isoflurane sedation.
An 18-year-old girl received isoflurane sedation for 48 h to facilitate mechanical ventilation. This resulted in a serum inorganic fluoride level of 37.3 mumol.l-1 when the isoflurane was stopped. As the serum fluoride level may continue to rise after isoflurane and as this level is approaching toxicity, the role of isoflurane sedation in the critically ill should be approached cautiously.
Breheny
F X
FX
Intensive Care Unit, Fremantle Hospital, Australia.
D000293:Adolescent; D003422:Critical Care; D005260:Female; D005459:Fluorides / Q000097:blood*; D006801:Humans; D006993:Hypnotics and Sedatives; D007530:Isoflurane / Q000009:adverse effects*; D012121:Respiration, Artificial; D013226:Status Epilepticus / Q000628:therapy
D006993:Hypnotics and Sedatives; D007530:Isoflurane; D005459:Fluorides