title: Delayed reactions to contrast media after interleukin-2 immunotherapy.
abstract: A prospective study was conducted by means of a questionnaire to determine the prevalence of delayed reactions to contrast media administered intravenously (iopamidol) and orally (diatrizoate sodium) in 170 patients who had received interleukin-2 (IL-2) and in 631 patients who did not. Another control group of 100 non-IL-2 patients received only oral contrast medium. Delayed reactions (eg, fever rash, flulike symptoms, joint pain, flushing, pruritus, and dizziness) were reported in 3.9% (25 of 631) of non-IL-2 patients and in 11.8% (20 of 170) of IL-2 patients. Reactions were mild in the non-IL-2 patients but were more severe in the IL-2 patients. Two IL-2 patients required hospitalization. Only rash, flulike symptoms, and pruritus were statistically more common in IL-2 patients than in non-IL-2 patients. The prevalence of delayed reactions to nonionic contrast medium is higher in patients who have received IL-2 than in the general population. Most delayed reactions do not require therapy, but, when necessary, therapy is usually limited to relief of symptoms.
authors.affiliation: Diagnostic Radiology Department, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: P L
authors.initials: PL
authors.lastname: Choyke
authors.forename: D L
authors.initials: DL
authors.lastname: Miller
authors.forename: M T
authors.initials: MT
authors.lastname: Lotze
authors.forename: J M
authors.initials: JM
authors.lastname: Whiteis
authors.forename: B
authors.initials: B
authors.lastname: Ebbitt
authors.forename: S A
authors.initials: SA
authors.lastname: Rosenberg
mesh_terms: D000284:Administration, Oral; D003973:Diatrizoate / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007167:Immunotherapy; D007275:Injections, Intravenous; D007376:Interleukin-2 / Q000627:therapeutic use*; D007479:Iopamidol / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D007376:Interleukin-2; D003973:Diatrizoate; D007479:Iopamidol