Neural mechanisms of hyperalgesia.
Hyperalgesia, or enhanced sensitivity to pain, is a symptom often associated with inflammation, nerve injury and various diseases. Although hyperalgesia appears to be mediated by sensitization of peripheral and central pain-signalling neurons, underlying mechanisms of sensitization are not well understood. Recent contributions to our knowledge of the mechanisms underlying hyperalgesia and sensitization are reviewed.
Simone
D A
DA
University of Minnesota, Minneapolis.
D000818:Animals; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology*; D010525:Peripheral Nerves / Q000166:cytology / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology