title: Trisomy 16 confined to chorionic villi and unfavourable outcome of pregnancy.
abstract: Two cases of trisomy 16 confined to placental tissue associated with an unfavourable outcome of the pregnancy are reported. In the first case, after a diagnosis of an apparent non-mosaic trisomy 16 at chorionic villi sample (CVS), an intrauterine fetal death occurred at the 22nd week. In the second case a mosaic with trisomy 16 was found in chorionic villi and the fetus was still-born at 38 weeks. From a comparison of their cases with those of the literature, the authors conclude that a trisomy 16 confined to placental tissue has a negative effect on fetal growth and pregnancy outcome.
authors.affiliation: Cattedra di Genetica Umana, Istituto di Scienze Biomediche S. Paolo, Università degli Studi di Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Simoni
authors.forename: B
authors.initials: B
authors.lastname: Brambati
authors.forename: F
authors.initials: F
authors.lastname: Maggi
authors.forename: L
authors.initials: L
authors.lastname: Jackson
mesh_terms: D000328:Adult; D002824:Chorionic Villi / Q000502:physiology*; D002885:Chromosomes, Human, Pair 16; D005260:Female; D005313:Fetal Death / Q000235:genetics*; D005317:Fetal Growth Retardation / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D014314:Trisomy