Does ondansetron attenuate amphetamine-induced behaviour in human volunteers?
The effect of the 5-HT3 receptor antagonist, ondansetron, on the decrease in hunger produced by amphetamine was assessed in nine male volunteers using a double-blind cross-over design. Amphetamine (15 mg orally) produced a significant decrease in self-ratings of hunger 2.5 h after administration. This effect was significantly attenuated by pre-treatment with ondansetron (12 mg orally over 24 h). These findings in humans are consistent with data from animal studies suggesting that ondansetron can attenuate certain catecholamins-mediated behaviours produced by amphetamine. However, explanations founded on pharmacokinetic factors cannot be presently excluded.
Silverstone
P H
PH
Psychopharmacology Research Unit, Littlemore Hospital, Oxford, UK.
Johnson
B
B
Cowen
P J
PJ
D000328:Adult; D000661:Amphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001519:Behavior / Q000187:drug effects*; D006801:Humans; D006815:Hunger / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D017294:Ondansetron; D012016:Reference Values; D012702:Serotonin Antagonists
D007093:Imidazoles; D012702:Serotonin Antagonists; D017294:Ondansetron; D000661:Amphetamine