Unusual cardiovascular localization of nonamyloid immunoglobulin deposition disease causing sudden death.
The case of a 38-yr-old man is presented in whom sudden death was attributed to coronary ostial stenosis caused by aortic intimal deposits of an amyloid-like material. Autopsy revealed wide-spread lymphocytic lymphoma with kappa light chain restriction. Histochemistry, immunoperoxidase light microscopy, transmission electron microscopy, and immunoelectron microscopy identified the coronary ostial, and massive other cardiovascular, deposits as para-amyloid of kappa light chain origin.
Walley
V M
VM
University of Ottawa Heart Institute, Department of Anatomical Pathology, Ottawa Civic Hospital, Canada.
Silver
M M
MM
D000328:Adult; D001011:Aorta / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D001024:Aortic Valve Stenosis / Q000150:complications / Q000378:metabolism; D002319:Cardiovascular System / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D003645:Death, Sudden / Q000209:etiology*; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis* / Q000378:metabolism; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron
D007145:Immunoglobulin kappa-Chains