Formation of PAF-like compounds by peroxidation of phospholipids from bovine brain.
This short review describes the identification by mass spectrometry of phospholipids having an sn-2-short-chain monocarboxylate, dicarboxylate or omega-hydroxycarboxylate group in a fraction with PAF-like activity from a bovine brain lipid extract. The similar molecular heterogeneities of these unique phospholipids suggest that they are formed via a common mechanism, possibly peroxidation of membrane phosphatidylcholines. This possibility is supported by the finding that these PAF-like compounds were actually formed during peroxidation of synthetic phosphatidylcholines induced by Fe2+/ascorbate/EDTA.
Tokumura
A
A
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Tanaka
T
T
Yotsumoto
T
T
Tsukatani
H
H
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D015227:Lipid Peroxidation; D013058:Mass Spectrometry; D010743:Phospholipids / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000096:biosynthesis*; D010974:Platelet Aggregation / Q000187:drug effects
D010743:Phospholipids; D010972:Platelet Activating Factor