Interaction of moclobemide and tricyclic antidepressants with the tyramine pressor effect in rats.
Tyramine at high doses (20 mg/kg) increased arterial blood pressure in freely moving rats. This increase was completely prevented by pretreatment with inhibitors of neuronal membrane carriers for noradrenaline (e.g. desipramine or oxaprotiline). Pretreatment with moclobemide induced a mild potentiation of this tyramine-pressor effect which could also be attenuated dose-dependently by co-administration of oxaprotiline.
Burkard
W
W
Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
d'Agostini
F
F
Kettler
R
R
Da Prada
M
M
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D020912:Moclobemide; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D014439:Tyramine / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D020912:Moclobemide; D009638:Norepinephrine; D014439:Tyramine