Regulation of the expression of the rat angiotensin II receptor mRNA.
Regulation of the expression levels of the rat angiotensin II receptor mRNA in the adrenal, aorta, kidney, and brain was assessed by the competitive polymerase chain reaction method. The bilateral nephrectomy or the administration of Dup753 markedly reduced the expression levels of this receptor mRNA in the adrenal and brain stem, but not in the kidney nor aorta. A continuous infusion of angiotensin II increased the expression level of this receptor mRNA in the adrenal but not in the other tissues. It is suggested that the expression level of this receptor mRNA in the adrenal is dependent on the renin angiotensin aldosterone system.
Iwai
N
N
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Inagami
T
T
D000199:Actins / Q000235:genetics; D000311:Adrenal Glands / Q000502:physiology*; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000502:physiology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D001933:Brain Stem / Q000502:physiology*; D002460:Cell Line; D002872:Chromosome Deletion; D005786:Gene Expression Regulation / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology; D007668:Kidney / Q000502:physiology*; D019808:Losartan; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D009392:Nephrectomy; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011945:Receptors, Angiotensin / Q000235:genetics*; D013777:Tetrazoles / Q000494:pharmacology
D000199:Actins; D001713:Biphenyl Compounds; D007093:Imidazoles; D012333:RNA, Messenger; D011945:Receptors, Angiotensin; D013777:Tetrazoles; D000804:Angiotensin II; D019808:Losartan