title: [Clinical studies on tosufloxacin (TFLX) in urology].
abstract: We clinically evaluated the usefulness of a new oral antimicrobial agent, TFLX, in the field of urology. The dose administered was 150 mg t.i.d and the duration of administration was 3 days. The clinical effect was evaluated according to the criteria of the Japanese UTI committee. The clinical response obtained on 164 female patients with acute simple cystitis was excellent in 118, moderate in 44 and poor in 2 patients. The efficacy rate was 98.78%. The clinical response obtained on 4 male patients with acute simple cystitis was excellent in 2 and moderate in 2 patients. The efficacy rate was 100%. The clinical response obtained on 3 female patients with simple pyelonephritis was excellent in 2 and moderate in 1 patient. The efficacy rate was 100%. The clinical response obtained on one patient with non-gonococcal urethritis was excellent by doctor's evaluation. The clinical response obtained on 7 patients with complicated UTI was excellent in 3 and moderate in 4 patients. The efficacy rate was 100%. Three patients complained of stomach distress or malaise and 2 patients developed rash. No abnormal laboratory data were observed. Thus, TFLX appears to be safe and suitable for use in the field of urology.
authors.affiliation: Department of Urology, Yokohama Municipal Citizens Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Fukushima
authors.forename: M
authors.initials: M
authors.lastname: Moriyama
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Hosaka
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Noguchi
authors.forename: T
authors.initials: T
authors.lastname: Shuin
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: S
authors.initials: S
authors.lastname: Yoshimura
mesh_terms: D042462:4-Quinolones; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D003556:Cystitis / Q000188:drug therapy; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D011704:Pyelonephritis / Q000188:drug therapy; D014526:Urethritis / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C055185:tosufloxacin