title: HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.
abstract: Actin, one of the most abundant proteins of the cell, is hydrolyzed by the human immunodeficiency virus type 1 (HIV-1) protease during acute infection of cultured human T lymphocytes. The actin fragments produced during the course of infection are identical to those obtained by recombinant HIV-1 protease digests of (1) a lysate from uninfected T lymphocytes and (2) globular actin itself. Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis.
authors.affiliation: Biochemistry Unit, Upjohn Laboratories, Kalamazoo, MI 49001.
authors.forename: L D
authors.initials: LD
authors.lastname: Adams
authors.forename: A G
authors.initials: AG
authors.lastname: Tomasselli
authors.forename: P
authors.initials: P
authors.lastname: Robbins
authors.forename: B
authors.initials: B
authors.lastname: Moss
authors.forename: R L
authors.initials: RL
authors.lastname: Heinrikson
mesh_terms: D000199:Actins / Q000378:metabolism*; D002460:Cell Line; D015180:Electrophoresis, Gel, Two-Dimensional; D016333:HIV Protease / Q000378:metabolism*; D015497:HIV-1 / Q000201:enzymology* / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D013601:T-Lymphocytes / Q000382:microbiology
chemical_list: D000199:Actins; D016333:HIV Protease