title: [Ca2+] and [Na+] in rat ventricular myocytes showing negative and positive force frequency relationships.
abstract: Ventricular cells that show a positive force-frequency relationship show graded changes of intracellular [Ca2+] (Cai), [Na+] (Nai) and sarcoplasmic reticulum Ca2+ content with changes of stimulation frequency. Cells that show a negative force-frequency relationship show smaller changes of Nai and no change in the Ca2+ load of the sarcoplasmic reticulum as stimulation frequency is changed.
authors.affiliation: Department of Physiology, University of Leeds, U.K.
authors.forename: J E
authors.initials: JE
authors.lastname: Frampton
authors.forename: S M
authors.initials: SM
authors.lastname: Harrison
authors.forename: C H
authors.initials: CH
authors.lastname: Orchard
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*
chemical_list: D012964:Sodium; D002118:Calcium