Production of interleukin-1-like cytokine by cultured rat glomerular macrophages.
Resident glomerular macrophages from normal rats were isolated and grown through long-term cultures in order to obtain confluent cell monolayers. These cells have a secretory function as revealed by the production of a cytokine with a molecular weight similar to interleukin-1 (IL-1). The demonstration that rat glomerular macrophages secrete an IL-1-like cytokine emphasizes the role of these cells in a number of glomerular secretory functions, including some which have been commonly attributed only to mesangial contractile cells.
Mampaso
F
F
Department of Pathology, Hospital Ramon y Cajal Madrid, Spain.
Bricio
T
T
Martin
A
A
Molina
A
A
D000818:Animals; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005920:Glomerular Mesangium / Q000187:drug effects / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis*; D007678:Kidney Glomerulus / Q000166:cytology / Q000276:immunology*; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains
D007375:Interleukin-1; D008070:Lipopolysaccharides