Role of ciprofloxacin in typhoid fever.
A study was conducted to investigate the effects of ciprofloxacin in typhoid fever and to compare its efficacy with chloramphenicol. Eighty patients between 20-45 years with positive blood culture were included in the study. Seventy five percent patients treated with ciprofloxacin became afebrile within 72 hours while with chloramphenicol it took upto 120-144 hours for the same percentage of patients to become afebrile. Four patients resistant to chloramphenicol, cotrimoxazole and ampicillin/amoxycillin, also responded to ciprofloxacin. There were no significant adverse effects indicating that ciprofloxacin is safe and effective drug for resistant and nonresistant cases of typhoid fever.
Akhtar
M A
MA
Division of Medicine, Army Medical College, Rawalpindi.
Hussain
A
A
Karamat
K A
KA
Naqi
N
N
Zubdi
N
N
D000328:Adult; D002701:Chloramphenicol / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D014435:Typhoid Fever / Q000188:drug therapy*
D002939:Ciprofloxacin; D002701:Chloramphenicol