title: Influence of anticoagulation on blood loss following dental extractions.
abstract: The coagulation activity level at which oral surgery procedures can be performed in anticoagulated patients without triggering bleeding complications and without enhancing the risk of developing thrombo-embolic events remains controversial. The objective of the present study was to evaluate blood loss following dental extractions at different levels of anticoagulation and to determine its effect on wound closure rates. Blood loss was measured following the removal of four front teeth in warfarinized rabbits. Immediate blood loss was evaluated by determining the tooth socket bleeding times and by using a technique based on hemoglobin determinations. Long-term blood loss was assessed by comparison of labeled red-blood-cell disappearance curves. The results showed that blood loss following dental extractions was significantly greater in animals anticoagulated at a therapeutic level than in non-anticoagulated control animals. Determination of blood loss at different levels of anticoagulation clearly demonstrated that complete correction of the coagulation activity was unnecessary. Partial correction (INR values of 1.6-1.8) allowed extractions to be performed without extensive blood loss. With this technique of partial correction, the period of interruption of the anticoagulation could be kept very short, and the risk of postoperative bleeding complications was minimal. Wound closure rates were negatively influenced in anticoagulated animals.
authors.affiliation: Catholic University of Leuven, School for Dentistry, Oral Pathology and Maxillofacial Surgery, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: DeClerck
authors.forename: F
authors.initials: F
authors.lastname: Vinckier
authors.forename: J
authors.initials: J
authors.lastname: Vermylen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001760:Bleeding Time; D016063:Blood Loss, Surgical / Q000706:statistics & numerical data*; D016009:Chi-Square Distribution; D003730:Dental Care for Persons with Disabilities; D011817:Rabbits; D014081:Tooth Extraction / Q000009:adverse effects*; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D014859:Warfarin