Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet.
Tubeimoside 1, one of the new triterpenoid saponins from the bulb of Bolbostemma paniculatum (Maxim) Franquet, had an anti-inflammatory effect on mouse ear edema induced by arachidonic acid and 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, a potent anti-tumorigenic effect of tubeimoside 1 was observed in 2-stage carcinogenesis of mouse skin after oral administration as well as topical application. Thus, tubeimoside 1 appears to be a promising agent for cancer chemoprevention.
Yu
L J
LJ
Department of Biochemistry, Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, Xian, People's Republic of China.
Ma
R D
RD
Wang
Y Q
YQ
Nishino
H
H
Takayasu
J
J
He
W Z
WZ
Chang
M
M
Zhen
J
J
Liu
W S
WS
Fan
S X
SX
D000287:Administration, Topical; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D005260:Female; D051379:Mice; D012503:Saponins / Q000008:administration & dosage / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014315:Triterpenes
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; C051084:tubeimoside I; D013755:Tetradecanoylphorbol Acetate