[Unilateral leukopathia unguis toxica and diffuse hair loss after cytostatic perfusion of an extremity].
We report on a patient with simultaneous manifestation of two different side-effects of a cytostatic therapy, which have to be ascribed to cytotoxic influences of different intensity. In this 37-year-old woman, "Mees-like" transverse white bands appeared on all the nails on the left hand after isolated cytostatic perfusion of the left arm. The nails on the right hand and the feet remained free of visible changes. However, the low doses of cytostatic drugs shunted into the systematic circulation induced diffuse toxic hair loss.
Zaun
H
H
Hautklinik, Universität des Saarlandes, Homburg/Saar.
Omlor
G
G
D000328:Adult; D000505:Alopecia / Q000139:chemically induced*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D010478:Chemotherapy, Cancer, Regional Perfusion; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D005542:Forearm / Q000601:surgery; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000601:surgery; D008558:Melphalan / Q000008:administration & dosage / Q000009:adverse effects; D009260:Nail Diseases / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000601:surgery
D002945:Cisplatin; D008558:Melphalan
Einseitige Leukopathia unguis toxica und diffuser Haarausfall nach zytostatischer Extremitätenperfusion.