The dilemma of a low rate of chromosomal mosaicism found in fetal blood sampling.
We report a case in which mosaicism of trisomy 13 was detected in 4/10 cells (40 per cent) in amniotic fluid cell cultures, followed by a low rate of mosaicism (1/160 cells) detected in a fetal blood sample. This finding presents a dilemma both for the genetic counsellor and for the parents in determining whether or not to terminate the pregnancy.
Fejgin
M
M
Genetics Unit, Sapir Medical Center, Kfar Saba, Israel.
Barnes
I
I
Lipnick
N
N
Magid
Z
Z
Kohn
G
G
Amiel
A
A
D000328:Adult; D002882:Chromosomes, Human, Pair 13; D003937:Diagnosis, Differential; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D009030:Mosaicism; D011296:Prenatal Diagnosis; D014314:Trisomy