Nifedipine in divided doses does not reverse left ventricular hypertrophy in spontaneously hypertensive rats.
This study investigated whether nifedipine administered in divided daily doses would diminish left ventricular hypertrophy (LVH) in spontaneously hypertensive rats (SHR). We administered nifedipine (12 mg/kg/day) in 3 divided doses by gastric gavage to 15-week-old male SHR (n = 10) for 4 weeks. Age- and sex-matched SHR served as controls (n = 10). Left ventricular (LV) function was evaluated by LV catheterization and cardiac output was determined by the thermodilution method. Plasma renin activity (PRA) and plasma norepinephrine levels were measured. Nifedipine significantly decreased blood pressure (p less than 0.01), shortened time constant T (p less than 0.05), and increased cardiac output (p less than 0.05). Nifedipine did not impair the LV systolic and diastolic indices during acute afterload elevation with angiotensin II. LV weight was similar in the 2 groups of rats. While PRA was unaltered, plasma norepinephrine levels were higher in the nifedipine-treated rats (p less than 0.05). These data indicate that nifedipine in 3 divided doses reduced blood pressure in SHR without compromising cardiac function but did not reverse LVH. The short hypotensive duration of nifedipine and its enhancement of sympathetic nervous activity may be responsible for the failure to reverse LVH, despite adequate blood pressure control.
Nishimura
H
H
Third Department of Internal Medicine, Osaka Medical College, Japan.
Kubota
J
J
Okabe
M
M
Ueyama
M
M
Kawamura
K
K
D000320:Adrenergic Fibers / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006332:Cardiomegaly / Q000473:pathology / Q000503:physiopathology*; D004334:Drug Administration Schedule; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000150:complications*; D008297:Male; D009200:Myocardial Contraction; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D012084:Renin-Angiotensin System; D016277:Ventricular Function, Left / Q000187:drug effects
D009543:Nifedipine