Analgesic activity of anticancer agent suramin.
Suramin exhibited morphine-like analgesic activity in mice. It antagonized both thermal (hot-plate) and acetic acid-evoked writhing responses with ED50 values 1/100 and 1/68, respectively, that of morphine. The suramin- and morphine-induced hot-plate analgesia was suppressed by administration of 0.5 mg/kg naloxone. However, lower doses (5-30 micrograms/kg) of naloxone produced dose-related potentiation or suppression of suramin and morphine analgesia. This potentiation effect may be due to the inhibition of writhing by naloxone itself rather than be a direct antagonism of the morphine effect.
Ho
B T
BT
Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston 77030.
Huo
Y Y
YY
Lu
J G
JG
Newman
R A
RA
Levin
V A
VA
D000698:Analgesia; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine; D009270:Naloxone; D010147:Pain Measurement; D013498:Suramin / Q000494:pharmacology*
D000700:Analgesics; D009270:Naloxone; D013498:Suramin; D009020:Morphine