Facilitation of specific tolerance induction in adult mice by RS-61443.
RS-61443 is an immunosuppressive agent that facilitates pancreatic islet allograft acceptance in two mouse strain combinations (BALB/c----CBA and C57Bl/6J----BALB/c). A remarkable feature of this agent is its ability to facilitate long-term graft acceptance after a short (30 days) period of treatment; following withdrawal of the agent 40-70% of islet allografts are maintained for an indefinite period. This long-term graft acceptance has been shown to result from specific tolerance induction in the recipient animal. The state of specific tolerance is an active rather than a passive form of tolerance, such as clonal deletion or anergy. Active tolerance induction is cyclosporine-sensitive, although cyclosporine enhances graft acceptance when used in combination therapy with RS-61443, this agent inhibits tolerance development under the influence of RS-61443.
Hao
L
L
Barbara Davis Center for Childhood Diabetes, Department of Microbiology/Immunology and Pediatrics, University of Colorado Health Sciences Center, Denver 80262.
Calcinaro
F
F
Gill
R G
RG
Eugui
E M
EM
Allison
A C
AC
Lafferty
K J
KJ
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006085:Graft Survival / Q000187:drug effects; D007108:Immune Tolerance / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016381:Islets of Langerhans Transplantation / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009173:Mycophenolic Acid