Dose responsive suppression of myointimal hyperplasia by dexamethasone.
The effect of increasing doses of dexamethasone on the development of myointimal hyperplasia in the rabbit carotid artery was studied by use of a balloon catheter injury model. Seventy New Zealand white rabbits underwent a standardized 2F balloon catheter stripping of the left carotid intima. The animals were randomly assigned to one of seven groups, each receiving daily injections of either saline (group I, N = 10) or graded doses of dexamethasone: 0.025 mg/kg (group II, N = 10); 0.050 mg/kg (group III, N = 10); 0.075 mg/kg (group IV, N = 10); 0.100 mg/kg (group V, N = 10); 0.125 mg/kg (group VI, N = 10); 0.150 mg/kg (group VII, N = 10). Injections were started 2 days before the intimal injury and continued daily, five times a week, for 8 weeks. The vessels were harvested 12 weeks after injury, and the ratio of the absolute area of intimal hyperplasia to the normalized area enclosed by the internal elastic lamina was measured as an index of myointimal hyperplasia. Also, at the time of harvest, blood flow (ml/min) was measured and the resistance delta P/flow (mm Hg/ml/min) calculated for each vessel in vivo. Twelve-week patency rates were 60% in the control group I, 90% in groups II and III, and 100% in groups IV, V, VI, and VII. The value for the intimal hyperplasia/internal elastic lamina index, expressed as a percent, was 22.2 +/- 3.7 for control group I, 17.7 +/- 2.1 group II, 14.8 +/- 3.0 group III, 12.8 +/- 2.4 group IV, 11.5 +/- 1.8 group V, 5.4 +/- 1.3 group VI, and 3.9 +/- 1.1 for group VII.(ABSTRACT TRUNCATED AT 250 WORDS)
Colburn
M D
MD
Section of Vascular Surgery, UCLA School of Medicine 90024-1749.
Moore
W S
WS
Gelabert
H A
HA
Quiñones-Baldrich
W J
WJ
D000704:Analysis of Variance; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology*; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006965:Hyperplasia / Q000188:drug therapy; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D011817:Rabbits; D011897:Random Allocation
D003907:Dexamethasone