Metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in partially hepatectomized rats.
Changes in the metabolism of 1-(2-tetrahydrofuryl)-5-fluorouracil (tegafur) to 5-fluorouracil (5-FU) were examined in the plasma, lung, liver, stomach, small intestine, spleen and kidney in two-thirds partially hepatectomized rats. Concentrations of tegafur and 5-FU in plasma and tissues were determined 30 min after injecting 100 mg/kg of tegafur via the tail vein. The 5-FU concentration in the plasma remained unchanged for the first 7 days after hepatectomy. The tissue level of 5-FU was higher in the liver and kidney than in other organs examined, but there were no changes in levels of 5-FU in each organ examined. Our observations support the proposal that the conversion of tegafur to 5-FU is maintained in partially hepatectomized rats.
Maehara
Y
Y
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Takahashi
I
I
Yoshida
M
M
Emi
Y
Y
Baba
H
H
Kusumoto
H
H
Kohnoe
S
S
Sugimachi
K
K
D000818:Animals; D005472:Fluorouracil / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D005641:Tegafur / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D005641:Tegafur; D005472:Fluorouracil