title: Intrapulmonary sublesions detected before surgery in patients with lung cancer.
abstract: BACKGROUND
  The treatment of patients with multiple intrapulmonary lesions remains controversial.
  
  
  METHODS
  Fifty-three patients with lung cancer, in whom preoperative evaluation disclosed intrapulmonary nodules distinct from the main tumor, were analyzed retrospectively to establish the optimal treatment in such cases.
  
  
  RESULTS
  These sublesions proved to be intrapulmonary metastases (PM) in 16 cases (30%), multiple primary lung cancers in 7 cases (13%), and various nonmalignant lesions in the others. The survival of the 53 patients, and of patients with clinical Stage I/II disease in particular, compared favorably with that of all patients with resected lung cancer. Those with multiple sublesions had a poorer prognosis, irrespective of their nature. Although patients with PM as sublesions often had clinically advanced cancer, metastatic foci, per se, did not influence the survival data as calculated by a multivariate analysis.
  
  
  CONCLUSIONS
  The authors conclude that the existence of a solitary intrapulmonary sublesion should not preclude surgical treatment, unless surgery is contraindicated because of other clinical and radiologic findings.
authors.affiliation: Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Kanagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kunitoh
authors.forename: K
authors.initials: K
authors.lastname: Eguchi
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: R
authors.initials: R
authors.lastname: Tsuchiya
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: N
authors.initials: N
authors.lastname: Moriyama
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011859:Radiography; D012189:Retrospective Studies; D016019:Survival Analysis