title: Physiologic implications of adding small amounts of carbon dioxide to the gas mixture during inhalation of xenon.
abstract: In addition to being a physiologically active tracer of CBF, xenon (Xe) in subanesthetic concentrations produces a relatively mild lowering of carbon dioxide (CO2) in the blood and elevation of transcranial Doppler (TCD) velocity. The addition of small concentrations of CO2 (0.4-1.2%) to the inhaled mixture produced no measurable effect on end tidal (P(et)) CO2 or TCD velocity. Cerebral blood flow (CBF) alterations induced by Xe are minimized by allowing P(et)CO2 to fall, permitting quantitative measurement of CBF by the Xe/CT CBF method.
authors.affiliation: Department of Neurosurgery, University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: E C
authors.initials: EC
authors.lastname: Marks
authors.forename: H
authors.initials: H
authors.lastname: Yonas
authors.forename: M H
authors.initials: MH
authors.lastname: Sanders
authors.forename: J T
authors.initials: JT
authors.lastname: Love
authors.forename: C
authors.initials: C
authors.lastname: Maxwell
authors.forename: S
authors.initials: S
authors.lastname: Schimmerman
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014978:Xenon / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D002245:Carbon Dioxide; D014978:Xenon