title: Leukemia: stem cells, preleukemia and cure.
abstract: Several new or evolving concepts of leukemia biology and treatment are considered including: most leukèmias result from transformation of a stem cell, their phenotype reflecting the site of clonal expansion rather than transformation; most leukemias are preceded by one or more preleukemia phases; and cure may be possible by re-establishing preleukemia or forcing maturation of leukemia cells.
authors.affiliation: Department of Medicine, UCLA School of Medicine.
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
authors.forename: A
authors.initials: A
authors.lastname: Butturini
mesh_terms: D002471:Cell Transformation, Neoplastic; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D011289:Preleukemia / Q000628:therapy*; D013234:Stem Cells / Q000473:pathology*