Noncariogenicity of maltitol in specific pathogen-free rats infected with mutans streptococci.
The effect of maltitol on caries development was examined in an experimental caries system employing specific pathogen-free (SPF) Sprague-Dawley rats. Fourteen strains of oral streptococci, including mutans streptococci, did not utilize the maltitol nor produce sufficient acid to demineralize tooth enamel. Furthermore, maltitol did not serve as a substrate for glucosyltransferases of either Streptococcus mutans MT8148R or Streptococcus sobrinus 6715 to synthesize water-insoluble glucan. Maltitol induced no significant dental caries in SPF rats infected with these mutans streptococci, and replacement of the dietary sucrose content with maltitol resulted in a trend towards caries reduction in SPF rats.
Ooshima
T
T
Department of Pedodontics, Osaka University Faculty of Dentistry, Japan.
Izumitani
A
A
Minami
T
T
Yoshida
T
T
Sobue
S
S
Fujiwara
T
T
Hamada
S
S
D000818:Animals; D001422:Bacterial Adhesion; D002327:Cariostatic Agents / Q000378:metabolism* / Q000494:pharmacology; D003731:Dental Caries / Q000209:etiology / Q000382:microbiology*; D003773:Dental Plaque / Q000209:etiology / Q000382:microbiology; D005936:Glucans / Q000096:biosynthesis; D008297:Male; D008320:Maltose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D013047:Specific Pathogen-Free Organisms; D013291:Streptococcus / Q000378:metabolism; D013295:Streptococcus mutans / Q000378:metabolism*; D013298:Streptococcus sanguis / Q000378:metabolism; D016986:Streptococcus sobrinus / Q000378:metabolism; D013395:Sucrose / Q000378:metabolism; D013402:Sugar Alcohols / Q000378:metabolism* / Q000494:pharmacology; D013549:Sweetening Agents / Q000378:metabolism* / Q000494:pharmacology
D002327:Cariostatic Agents; D005936:Glucans; D011135:Polysaccharides, Bacterial; D013402:Sugar Alcohols; D013549:Sweetening Agents; D013395:Sucrose; D008320:Maltose; C010745:maltitol