[Warmed water administered into tumor feeding artery via percutan-trans-catheter (PTC) as thermotherapy after chemotherapy].
1. Experimental Study. Walker-256 (5 x 10(7) cells, which were resistant to hyperthermia, were implanted into the dorsal hind paw of Wistar rats. Warmed (37 degrees C or 40 degrees C) physiological saline using 0.05% of noradrenaline injected into the tumor feeding artery (PTCT) after chemotherapy in D-4 and D-8 groups. (When tumor cells were implanted 4 days before in D-4 group and the tumor vessels were not formed. In D-8 group, when implanted 8 days before, many tumor vessels were observed.) The tumor growth curve at 6 days after treatment by PTCT (40 degrees C) and chemotherapy was inhibited in the D-8 group, not in the D-4 group. The tumor blood flow rate was about 80% impaired compared with the controls at 60 minutes. Microcirculatory disturbance of the tumor vessels was found in 6 (12) hours after PTCT and chemotherapy, even though the temperature of the tumor tissue was no more than 32 degrees C. 2. Clinical study. Warmed (47 degrees C) 5% glucose solution with addition of 0.05 mg of noradrenaline (PTCT) after chemotherapy (MMC: 6-10 mg, or CDDP: 10 mg) was administered into the tumor feeding artery of liver tumor (7 cases), pancreas tumor (4 cases), gall bladder tumor (2 cases) and metastatic bone tumor (1 case) with 80% (12/15) PR.
Satou
T
T
Dept. of Surgery, Koriyama National Hospital.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000098:blood supply / Q000473:pathology / Q000628:therapy*; D005947:Glucose / Q000008:administration & dosage; D006358:Hot Temperature / Q000627:therapeutic use*; D007269:Injections, Intra-Arterial; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage*; D009638:Norepinephrine / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D013696:Temperature
D012462:Saline Solution, Hypertonic; D016685:Mitomycin; D005947:Glucose; D009638:Norepinephrine