Increase in glucose consumption by acetylcysteine during hyperglycemic clamp. A study with healthy volunteers.
Thiols have been shown to be related to insulin secretion and to uptake of glucose into tissues. In the present study the effects of i.v. administration of acetylcysteine (N-acetylcysteine, NAC, CAS 616-91-1) on glucose consumption and plasma free thiols were studied in young healthy volunteers during hyperglycemic clamp. NAC (0.5-2.0 mg/kg) significantly increased glucose consumption. This effect was not obvious at higher doses of NAC. Plasma free NAC depended on the dose of NAC injected. The t1/2 of NAC was 11 min. NAC produced significant increases of plasma cysteine concentrations, and a slight but insignificantly increase of plasma glutathione. These data suggest that a moderate increase in plasma thiols augments glucose consumption during hyperglycemic clamp.
Ammon
H P
HP
Department of Pharmacology, University of Tübingen, Fed. Rep. of Germany.
Müller
P H
PH
Eggstein
M
M
Wintermantel
C
C
Aigner
B
B
Safayhi
H
H
Stützle
M
M
Renn
W
W
D000111:Acetylcysteine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005978:Glutathione / Q000097:blood; D006207:Half-Life; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008954:Models, Biological
D001786:Blood Glucose; D007328:Insulin; D005978:Glutathione; D005947:Glucose; D000111:Acetylcysteine