title: [A new adjuvant therapy modality in the treatment of superficial bladder carcinoma. Study of feasibility of postoperative radiotherapy "flash"].
abstract: The Authors present the preliminary results of a feasibility study on the use of adjuvant radiotherapy (6 Gy single fraction, postoperatively, "flash") as a new treatment modality for superficial bladder cancer (Ta-T1, N0, M0, previously relapsed or not, G I-III). The rationale for this study derives mainly from the favourable results obtained with external beam radiotherapy, when applied before interstitial radiotherapy as a method to avoid scar relapses. Data regarding 55 cases treated with the "flash" are compared retrospectively with those regarding more than 100 cases treated with different types of "conventional" adjuvant therapy at the INRCA Center of Urology, during the last 3-4 years. The Authors stress the need for a prospective, randomized study of selected cases, to clarify if an adjuvant therapeutic modality is superior to the others. The radiotherapeutic option ("flash"), however, clearly produces less iatrogenic damage than the others, and is simpler and cheaper.
authors.affiliation: Unità di Radioterapia, USSL 10/D, Università degli Studi di Firenze.
authors.forename: S
authors.initials: S
authors.lastname: Magrini
authors.forename: F
authors.initials: F
authors.lastname: Melone
authors.forename: A
authors.initials: A
authors.lastname: Chiavacci
authors.forename: G
authors.initials: G
authors.lastname: Biti
authors.forename: O
authors.initials: O
authors.lastname: Gazzarrini
authors.forename: G
authors.initials: G
authors.lastname: Muraro
authors.forename: R
authors.initials: R
authors.lastname: Benelli
authors.forename: M
authors.initials: M
authors.lastname: Gavazzi
authors.forename: P
authors.initials: P
authors.lastname: Ponticelli
authors.forename: C
authors.initials: C
authors.lastname: Rimondi
mesh_terms: D001500:BCG Vaccine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery / Q000628:therapy
chemical_list: D001500:BCG Vaccine
vernacular_title: Una nuova modalità di terapia adiuvante nel trattamento dei carcinomi vescicali superficiali. Studio di fattibilità del "flash" radioterapico postoperatorio.