title: Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin.
abstract: The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R-(+)-PL in terms of penetration through rat stratum corneum.
authors.affiliation: Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: F
authors.initials: F
authors.lastname: Kaiho
authors.forename: A
authors.initials: A
authors.lastname: Inagaki
authors.forename: M
authors.initials: M
authors.lastname: Dohi
authors.forename: N
authors.initials: N
authors.lastname: Hazemoto
authors.forename: M
authors.initials: M
authors.lastname: Haga
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D011433:Propranolol / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption; D013237:Stereoisomerism
chemical_list: D011433:Propranolol