title: Probability of finding a compatible sibling donor for bone marrow transplantation in Ireland.
abstract: This study was undertaken to ascertain the frequency of compatible sibling donors for individuals requiring bone marrow transplantation (BMT) in Ireland. During the study period 1984-89, a total of 392 patients were HLA typed. Of these, 218 (55.6%) had a compatible sibling donor. Among the latter there were 4 degrees of compatibility: 168 (42.9%) were HLA-A,B,DR identical MLC unreactive: three (0.8%) were HLA-A,B,DR identical MLC reactive: 12 (3.0%) were HLA-A,B,DR identical (no MLC performed) and 35 (8.9%) were HLA-A, B identical (no DR or MLC performed). The leukaemias and aplastic anaemia comprised 82.9% of all requests. The majority of patients with acute myeloid leukaemia (64.4%), acute lymphoblastic leukaemia (51.2%), chronic myeloid leukaemia (73.9%) and aplastic anaemia (77.3%) had a potential sibling donor. Subsequently 144 of these patients had an allogeneic BMT, 79.9% of which were for patients with leukaemia (acute and chronic). This study found that there was a higher probability of finding a donor within the family than reported in most series. A clear relationship was demonstrated between family size and the likelihood of obtaining a HLA-identical sibling donor.
authors.affiliation: Department of Haematology, St James's Hospital, Dublin, Ireland.
authors.forename: J
authors.initials: J
authors.lastname: O'Riordan
authors.forename: A
authors.initials: A
authors.lastname: Finch
authors.forename: E
authors.initials: E
authors.lastname: Lawlor
authors.forename: S R
authors.initials: SR
authors.lastname: McCann
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology*; D006680:HLA Antigens; D006402:Hematologic Diseases / Q000601:surgery; D006650:Histocompatibility Testing; D006801:Humans; D007494:Ireland; D007938:Leukemia / Q000601:surgery; D007959:Lymphocyte Culture Test, Mixed; D009369:Neoplasms / Q000601:surgery; D011336:Probability; D012801:Sibling Relations; D014019:Tissue Donors; D009927:Tissue and Organ Procurement
chemical_list: D006680:HLA Antigens