Endothelium-derived hyperpolarizing factor (EDHF).
In vascular tissues, many types of stimulants which release endothelium-derived relaxing factor (EDRF) hyperpolarized the smooth muscle membrane in an endothelium-dependent manner. The hyperpolarizations were resistant to inhibitors of the actions of EDRF, thereby suggesting that they were elicited by an unidentified substance called endothelium-derived hyperpolarizing factor (EDHF). The EDHF induced hyperpolarization was produced by an increase in K(+)-permeability of the membrane, and was one of the factors to induce endothelium-dependent vasodilations. Release of EDHF required an increase in endothelial Ca2+, due either to release of Ca2+ from intracellular storage or to its influx from the external media.
Suzuki
H
H
Department of Physiology, Nagoya City University Medical School, Japan.
Chen
G
G
Yamamoto
Y
Y
D000818:Animals; D001685:Biological Factors / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D002463:Cell Membrane Permeability; D004285:Dogs; D004594:Electrophysiology; D004727:Endothelium / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000502:physiology; D011188:Potassium / Q000378:metabolism
D001685:Biological Factors; C067410:endothelium-dependent hyperpolarization factor; D011188:Potassium; D002118:Calcium