title: Stromal amyloid in pheochromocytomas.
abstract: Amyloid has been documented in the stroma of a number of neuroendocrine tumors. It is usually associated with elaboration of a polypeptide hormone product. Twenty-three adrenal pheochromocytomas occurring in 18 patients were graded for the extent of amyloid deposits on the hematoxylin-eosin-stained slides, confirmed to be amyloid by Congo red stain and polarization microscopy. Fourteen of 20 cases (70%) showed evidence of stromal amyloid; in two thirds of these cases, it was considered abundant. The awareness of amyloid deposits in approximately 70% of pheochromocytomas is important for surgical pathologists, as this occurrence has not been thought to be common in these tumors and might be a source of diagnostic difficulty.
authors.affiliation: Department of Pathology, Washington University Medical School, St. Louis, MO.
authors.forename: M M
authors.initials: MM
authors.lastname: Steinhoff
authors.forename: S A
authors.initials: SA
authors.lastname: Wells
authors.forename: K
authors.initials: K
authors.lastname: DeSchryver-Kecskemeti
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000737:chemistry* / Q000648:ultrastructure; D000682:Amyloid / Q000032:analysis*; D003224:Congo Red; D006801:Humans; D010673:Pheochromocytoma / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D000682:Amyloid; D003224:Congo Red