title: Simultaneous treatment of chickens with salinomycin and tiamulin in feed.
abstract: Laboratory and field experiments involving more than 100,000 birds were performed to assess the effect of simultaneous in-feed medication of chickens with salinomycin and tiamulin at various concentrations. In an artificial infection study with Mycoplasma gallisepticum, low levels of tiamulin (10-40 ppm) did not induce signs of ionophore intoxication with salinomycin at 60 ppm in the feed, whereas levels of 50 ppm caused early signs with a mild growth depression. A level of 20 ppm gave a maximum average improvement in growth rate of 12.5%. There was a dose-related response in mycoplasma lesion inhibition, with 50 ppm reducing lesions by 75%. In the two field trials, chickens suffering from mycoplasmosis complicated with infectious bronchitis and receiving 60 ppm salinomycin in the feed showed marked improvements in mortality rates, lesion scores, and feed-conversion efficiency when tiamulin was added at 20 ppm and 30 ppm in the feed. There were no signs of incompatibility between the two antibiotics at these levels.
authors.affiliation: Veterinary Medical Research Institute, Hungarian Academy of Sciences, Budapest.
authors.forename: L
authors.initials: L
authors.lastname: Stipkovits
authors.forename: E
authors.initials: E
authors.lastname: Csiba
authors.forename: G
authors.initials: G
authors.lastname: Laber
authors.forename: D G
authors.initials: DG
authors.lastname: Burch
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D004224:Diterpenes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004435:Eating / Q000187:drug effects; D009175:Mycoplasma Infections / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000517:prevention & control*; D011714:Pyrans / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012137:Respiratory System / Q000473:pathology; D012141:Respiratory Tract Infections / Q000517:prevention & control / Q000662:veterinary; D013047:Specific Pathogen-Free Organisms; D000095662:Polyether Polyketides
chemical_list: D004224:Diterpenes; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides; C014224:tiamulin