title: Effects of caffeine on paracetamol activation in rat and mouse liver microsomes.
abstract: 1. The effects of caffeine on the NADPH-dependent production of paracetamol-glutathione conjugate were studied in rat and mouse liver microsomes. 2. In the presence of caffeine, glutathione conjugate production in rat microsomes was enhanced, whereas that in mouse microsomes was not affected significantly, showing an apparent species difference. 3. The data partly explain the species difference in the effects of caffeine on paracetamol hepatotoxicity.
authors.affiliation: Division of Health Science, Tokyo Medical and Dental University, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Shigesawa
authors.forename: T
authors.initials: T
authors.lastname: Kamiyama
authors.forename: K
authors.initials: K
authors.lastname: Tajiri
authors.forename: H
authors.initials: H
authors.lastname: Miyakawa
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics*; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D008658:Inactivation, Metabolic; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000082:Acetaminophen; D002110:Caffeine; D009249:NADP; C034780:3-(glutathion-S-yl)acetaminophen