Absence of structural rearrangements of chromosome 11 in human primary malignant melanoma.
Cytogenetic analysis of 10 primary and 18 metastatic malignant melanomas revealed that structural abnormalities of chromosome 11 were present in 50% of metastatic lesions and were not found in primary tumors. Our findings suggest that chromosome 11 aberrations represent secondary changes in malignant melanoma tumorigenesis.
Nedoszytko
B
B
Department of Biology and Genetics, Medical Academy, Gdańsk, Poland.
Mrózek
K
K
Limon
J
J
D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D002999:Clone Cells; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D014407:Tumor Cells, Cultured