title: Angiotensin II stimulation of the rat pituitary tumoral cell proliferation in vitro.
abstract: The effect of angiotensin II (AT II) on proliferation of rat pituitary tumoral cells was investigated in vitro. The tumoral cells were isolated from the prolactin-secreting pituitary tumors induced by stilboestrol implantation. The incorporation of [3H]-thymidine into DNA was used as an index of cell proliferation. It was found that AT II significantly enhanced the [3H]-thymidine incorporation into pituitary tumoral cells in the concentrations of 10(-10) and 10(-8) M. The stimulatory effect disappeared at the concentration of 10(-6) M. The possible involvement of pituitary renin-angiotensin system in pituitary tumorigenesis was discussed.
authors.affiliation: Institute of Endocrinology, Medical Academy of Lodz, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Kunert-Radek
authors.forename: M
authors.initials: M
authors.lastname: Pawlikowski
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D010911:Pituitary Neoplasms / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D000804:Angiotensin II