Association of t(15;17) and t(8;21) in the initial phase of an acute promyelocytic leukemia.
Two clones were observed at the initial phase of an acute myelogenous leukemia (AML): 46,XX,t(15;17) and 46,XX,t(8;21),t(15;17). Clinical, immunologic, and morphologic findings were in favor of expression of both chromosomal anomalies. Relapse occurred after 12 months of complete remission with typical acute promyelocytic leukemia (APL) syndrome when t(15;17) alone was then most predominant.
Charrin
C
C
Laboratoire d'Hématologie et Cytogénétique, Hôpital Edouard Herriot, Lyon, France.
Ritouet
D
D
Campos
L
L
Devaux
Y
Y
Archimbaud
E
E
Fraisse
J
J
Fiere
D
D
Germain
D
D
D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D014178:Translocation, Genetic
D015703:Antigens, CD