Rhabdomyonecrosis experimentally induced in Wistar rats by Africanized bee venom.
Damage is reported to skeletal muscle experimentally induced in Wistar rats by Africanized bee venom (ABV). Rhabdomyonecrosis was demonstrated indirectly by increased serum levels of the enzymes aspartate-aminotransferase and total creatine kinase, and directly by necrosis and inflammation observed by standard light microscopy of skeletal muscle. To our knowledge, this is the first report of a systemic damaging effect of ABV on skeletal muscle of experimentally envenomated rats. These data appear to reproduce experimentally some of the findings reported in cases of human envenomation due to multiple Africanized bee stings.
Azevedo-Marques
M M
MM
Department of Internal Medicine, Faculty of Medicine, Ribeirão Preto, SP, Brazil.
Ferreira
D B
DB
Costa
R S
RS
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D001514:Bee Venoms / Q000633:toxicity*; D003402:Creatine Kinase / Q000097:blood*; D009132:Muscles / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology
D001514:Bee Venoms; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase