Fish oil decreases natural resistance of mice to infection with Salmonella typhimurium.
Mortality rate in mice fed fish oil for 4 weeks was remarkably higher after a very low peroral (PO) challenge with Salmonella typhimurium, as compared with those fed diets rich in either corn oil or hydrogenated coconut oil, or a low fat (chow) diet. None of the surviving mice fed the fish oil diet showed bacterial counts in their spleens, unlike 45.4% to 66.6% of surviving mice fed high fat or low fat diets. The spleens of mice fed fish oil presented the highest number of bacteria 7 days after intraperitoneal infection with the same bacterial strain. Thus, the current studies demonstrate that a diet rich in fish oil decreases host resistance to infection.
Chang
H R
HR
Department of Genetics and Microbiology, University of Geneva Medical School, Centre Médical Universitaire, Switzerland.
Dulloo
A G
AG
Vladoianu
I R
IR
Piguet
P F
PF
Arsenijevic
D
D
Girardier
L
L
Pechère
J C
JC
D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D001835:Body Weight; D004041:Dietary Fats / Q000494:pharmacology; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D007113:Immunity, Innate / Q000187:drug effects; D051379:Mice; D012481:Salmonella Infections, Animal / Q000276:immunology* / Q000401:mortality; D012486:Salmonella typhimurium
D004041:Dietary Fats; D005395:Fish Oils