title: Autologous bone marrow transplantation for adult poor-risk lymphoblastic lymphoma in first remission.
abstract: OBJECTIVE
  Adult patients with poor-risk lymphoblastic lymphoma (LBL) treated with intensive multiagent chemotherapy (acute lymphoblastic leukemia [ALL]-like regimens) have a poor prognosis, with a disease-free long-term survival rate of less than 20%, caused by a very high relapse rate. Thus, adult patients with poor-risk LBL are candidates for alternative intensive consolidation therapy.
  
  
  METHODS
  Nine adult patients with poor-risk LBL in first remission after treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP; six patients) or ALL-like regimens (three patients), were treated with high-dose cyclophosphamide and total body irradiation (TBI) followed by nonpurged autologous bone marrow transplantation (ABMT).
  
  
  RESULTS
  Two of nine patients relapsed at 4 and 8 months, respectively, after BMT, and one patient died of acute myeloblastic leukemia (AML) 7 months after ABMT without recurrence of his lymphoma. Six patients are in unmaintained first remission with a follow-up of 12 to 113 months (median, 53 months) after transplantation.
  
  
  CONCLUSIONS
  These results suggest that intensive consolidation therapy with high-dose cyclophosphamide and TBI followed by nonpurged ABMT may improve the long-term prognosis of this disease.
authors.affiliation: Department of Haematology, University Hospital Utrecht, The Netherlands.
authors.forename: L F
authors.initials: LF
authors.lastname: Verdonck
authors.forename: A W
authors.initials: AW
authors.lastname: Dekker
authors.forename: G C
authors.initials: GC
authors.lastname: de Gast
authors.forename: H M
authors.initials: HM
authors.lastname: Lokhorst
authors.forename: H K
authors.initials: HK
authors.lastname: Nieuwenhuis
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery* / Q000628:therapy; D012074:Remission Induction / Q000379:methods; D012307:Risk Factors; D014182:Transplantation, Autologous