Evidence for a clonal origin of relative penicillin resistance among type 9L pneumococci in northwestern Canada.
The relationships among capsular type, protein type, and penicillin resistance for capsular group 9 Streptococcus pneumoniae collected in northwestern Canada between 1974 and 1987 were examined. The group 9 relatively penicillin-resistant (RPR) isolates were of the rare 9L capsular type. Of 47 penicillin-susceptible (PS) group 9 isolates that were typed for capsule, only 1 was 9L. Among 29 PS group 9 isolates that were protein typed, 9 protein types were observed. Of the 70 RPR isolates, 51 were protein type P23, 1 was P19, and 18 could not be typed (P0). Protein types P23 differed from P0 by a single epitope on pneumococcal surface protein A. These results suggest that the Canadian P23 and P0 capsular group 9 isolates are likely subclones of a primordial 9L RPR strain.
Waltman
W D
WD
Department of Microbiology, University of Alabama, Birmingham 35294.
Talkington
D F
DF
Lipinski
A E
AE
Crain
M J
MJ
Dixon
J M
JM
Briles
D E
DE
D000911:Antibodies, Monoclonal / Q000276:immunology; D016667:Bacterial Capsules / Q000032:analysis*; D001426:Bacterial Proteins / Q000032:analysis; D006801:Humans; D010403:Penicillin Resistance / Q000235:genetics*; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics
D000911:Antibodies, Monoclonal; D001426:Bacterial Proteins