Hormonal and menstrual changes after laparoscopic sterilization by Falope-rings or Filshie-clips.
OBJECTIVE
To evaluate the influence of laparoscopic sterilization by Falope-rings (Cabot Medical Corp., Langhorne, PA) or Filshie-clips (Femcare, Nottingham, United Kingdom) on menstrual pattern and ovulatory function.


METHODS
A prospective, nonrandomized study of women sterilized by Falope-rings (n = 6) or Filshie-clips (n = 5). Menstrual charts were kept. Serum follicle-stimulating hormone (FSH), estradiol (E2) and progesterone (P) were measured by means of radioimmunoassay in one cycle before and 3, 6, and 12 months after the sterilization. Blood samples were drawn on day -6, -2, 0, +6, +10 of the menstrual cycle, ovulation corresponding to day 0. The women sterilized by Filshie-clips had abdominal ultrasonography of the ovaries measuring the leading follicle on day -6, -2, 0, +6 of the menstrual cycle.


METHODS
Twelve women, 25 to 38 years old, with regular menstrual cycles and no use of oral contraceptives or intrauterine contraceptive device at least 6 months before sterilization. One woman was excluded.


RESULTS
After the sterilization, all women reported unchanged menstrual pattern. The follicular rise in E2 unchanged, and FSH levels fell accordingly. Progesterone levels were ovulatory, but the midluteal P peak 3 months poststerilization was significantly decreased. Serial abdominal ultrasonography in women sterilized by Filshie-clips confirmed ovulation in all cycles except in one woman, who had an unruptured follicle in one cycle before and in the sixth cycle after sterilization.


CONCLUSIONS
Laparoscopic sterilization by Falope-rings or Filshie-clips does not seem to interfere with menstrual pattern or ovulatory function.
Thranov
I
I
Gentofte County Hospital, Rigshospitalet, Statens Seruminstitute, Copenhagen, Denmark.
Hertz
J B
JB
Kjer
J J
JJ
Andresen
A
A
Micic
S
S
Nielsen
J
J
Hancke
S
S
D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D010535:Laparoscopy; D008597:Menstrual Cycle; D008598:Menstruation / Q000502:physiology*; D010060:Ovulation; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D013246:Sterilization, Tubal / Q000295:instrumentation* / Q000379:methods
D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone