title: Globus pallidus calcification in Down syndrome with progressive neurologic deficits.
abstract: We report a 10-year-old Down syndrome patient who developed dystonia, choreoathetosis, dysarthria, and dysphagia beginning with hemiparesis. Cranial computed tomography disclosed bilateral calcification in the globus pallidus which resembled a sign of premature aging. Conversely, the clinical course and magnetic resonance imaging findings resembled those of Hallervorden-Spatz syndrome.
authors.affiliation: Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okano
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: E
authors.initials: E
authors.lastname: Kohmura
authors.forename: H
authors.initials: H
authors.lastname: Yoshioka
authors.forename: T
authors.initials: T
authors.lastname: Sawada
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000175:diagnosis* / Q000473:pathology; D005917:Globus Pallidus / Q000473:pathology*; D006429:Hemiplegia / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D009468:Neuromuscular Diseases / Q000175:diagnosis* / Q000473:pathology; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000175:diagnosis* / Q000473:pathology; D012618:Sea-Blue Histiocyte Syndrome / Q000175:diagnosis / Q000473:pathology; D014057:Tomography, X-Ray Computed