title: Persistent gastrointestinal symptoms after correction of malrotation.
abstract: Persistent vomiting, diarrhoea, or intolerance of feeding, are well recognised problems in children after surgical correction of intestinal malrotation. Conversely, intestinal malrotation is a common accompaniment of chronic idiopathic intestinal pseudo-obstruction. We investigated motor activity of the small intestine during fasting in eight children who had persistent vomiting, intolerance of full enteral feeding, or severe diarrhoea after surgical correction of intestinal malrotation. Abnormality of motor function similar to that found in neuropathic pseudo-obstruction was found in seven of the eight patients. Persistence of symptoms after surgical correction of a malrotation is associated with a motility disturbance which seems to be due to a defect of intrinsic enteric innervation. Such a defect may be important in the aetiology of the malrotation.
authors.affiliation: Institute of Child Health, University of London.
authors.forename: S P
authors.initials: SP
authors.lastname: Devane
authors.forename: R
authors.initials: R
authors.lastname: Coombes
authors.forename: V V
authors.initials: VV
authors.lastname: Smith
authors.forename: W M
authors.initials: WM
authors.lastname: Bisset
authors.forename: I W
authors.initials: IW
authors.lastname: Booth
authors.forename: B D
authors.initials: BD
authors.lastname: Lake
authors.forename: P J
authors.initials: PJ
authors.lastname: Milla
mesh_terms: D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology; D005247:Feeding Behavior / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology / Q000503:physiopathology; D007421:Intestine, Small / Q000002:abnormalities* / Q000601:surgery*; D008365:Manometry; D011183:Postoperative Complications / Q000209:etiology*; D014102:Torsion Abnormality; D014839:Vomiting / Q000209:etiology