title: Adhesion of rheumatoid peripheral blood and synovial fluid mononuclear cells to high endothelial venules of gut mucosa.
abstract: Mononuclear cells isolated from paired blood and synovial fluid of seven patients with rheumatoid arthritis showed cytoadherence to porcine Peyer's patch high endothelial venules using the Stamper-Woodruff method. A significantly greater proportion of binding was found among the synovial fluid lymphocytes. These would appear to be a population of cells that share adherence characteristics with cells known to be of gut mucosal origin, suggesting that in rheumatoid arthritis some lymphocytes derived from mucosa migrate to joints.
authors.affiliation: Department of Microbiology, Leicester, United Kingdom.
authors.forename: A
authors.initials: A
authors.lastname: Kadioglu
authors.forename: P
authors.initials: P
authors.lastname: Sheldon
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002448:Cell Adhesion / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013582:Synovial Fluid / Q000166:cytology*; D014699:Venules / Q000166:cytology