title: The contributions to solvent uptake by skin and inhalation exposure.
abstract: Solvent exposures were assessed among 97 auto body repair workers in order to determine whether skin contact represented a significant route of exposure. Each subject's cumulative skin exposure was ranked categorically based on simple observation: 49 none, 33 incidental or low, and 15 moderate or high. The median time-weighted average air exposure to solvents was 8.4% of the American Conference of Governmental Industrial Hygienists (ACGIH) combined solvent threshold limit value (TLV) with a range of 0-62% TLV, including toluene (median 4 ppm) and xylenes (median 0.9 ppm). Urine methyl hippuric acids (MHAs, metabolites of xylenes) were low compared to the ACGIH biological exposure index (BEI) with a median of 2% and a range of 0-12% BEI but were strongly correlated with both the level of airborne xylenes and skin exposure when considered simultaneously by using analysis of covariance (R = 0.91, p less than 0.0001). MHA excretion attributable to skin exposure for 15 min or more generally was comparable to or greater than that from associated air exposure over the full work shift. This study had limited ability to assess quantitatively the contributions of toluene exposures, but there was evidence that skin exposures also contributed significantly to toluene absorption. Air sampling will substantially underestimate a worker's total solvent dose in the setting of moderate or high skin exposure. Simple observation was effective in identifying workers in this sample who appeared to have sufficient skin exposure to produce a measurable increase in solvent uptake.
authors.affiliation: Department of Environmental Health, University of Washington, Seattle 98195.
authors.forename: W
authors.initials: W
authors.lastname: Daniell
authors.forename: A
authors.initials: A
authors.lastname: Stebbins
authors.forename: D
authors.initials: D
authors.lastname: Kalman
authors.forename: J F
authors.initials: JF
authors.lastname: O'Donnell
authors.forename: S W
authors.initials: SW
authors.lastname: Horstman
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis / Q000493:pharmacokinetics*; D000704:Analysis of Variance; D001336:Automobiles; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D004784:Environmental Monitoring; D006626:Hippurates / Q000652:urine; D006801:Humans; D001239:Inhalation; D008297:Male; D008452:Maximum Allowable Concentration; D016273:Occupational Exposure; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D012997:Solvents / Q000493:pharmacokinetics*
chemical_list: D000395:Air Pollutants, Occupational; D006626:Hippurates; D012997:Solvents; D003404:Creatinine; C030514:hippuric acid