title: VAD or VMBCP in severe multiple myeloma. The Groupe d'Etudes et de Recherche sur le Myélome (GERM).
abstract: A randomized trial has been performed in which 91 patients with stage III myeloma and additional severe criteria were randomly allocated to either VAD or VMBCP. No significant difference was noted between these two groups using the following criteria: response rate (VMBCP: 54%; VAD: 39%), impact on symptoms, median survival (VMBCP: 14 months, VAD: 17 months). However, toxic effects and refusal to pursue treatment were more frequent with VAD than with VMBCP (12 v 6). Therefore, in this trial, VMBCP appears to be more useful than VAD.
authors.affiliation: Laboratory of Haematology, Charles Nicolle Hospital, Rouen, France.
authors.forename: M
authors.initials: M
authors.lastname: Monconduit
authors.forename: J F
authors.initials: JF
authors.lastname: Menard
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: X
authors.initials: X
authors.lastname: Le Loet
authors.forename: J F
authors.initials: JF
authors.lastname: Bernard
authors.forename: B
authors.initials: B
authors.lastname: Grosbois
authors.forename: J P
authors.initials: JP
authors.lastname: Pollet
authors.forename: I
authors.initials: I
authors.lastname: Azais
authors.forename: J P
authors.initials: JP
authors.lastname: Laporte
authors.forename: C
authors.initials: C
authors.lastname: Doyen
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002330:Carmustine / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000401:mortality; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014750:Vincristine; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D008558:Melphalan; D002330:Carmustine; D011241:Prednisone