Dopamine D1 antagonists potentiate the durations of bar and cling catalepsy and the dorsal immobility response in rats.
The effects of dopamine D1 antagonists SCH 23390 or SK&F 83566 (at SC doses of 0.00, 0.01, 0.05, and 0.1 mg/kg) were tested for 2 h on bar and cling catalepsy and the dorsal immobility response. Each of the drugs potentiated the duration of each of the three measures of immobility in a dose- and time-dependent manner. Each of the drugs had rapid but brief effects on all three response measures; the peak effect of SK&F 83566 took place at 20 min and that for SCH 23390 at 40 min for each behavior. At each effective drug dose, SCH 23390 had a greater effect than SK&F 83566 on each behavior. Dopamine D1 antagonists potentiated three different immobility responses, as do dopamine D2 antagonists.
Meyer
M E
ME
Department of Psychology, University of Florida, Gainesville 32611.
Cottrell
G A
GA
Van Hartesveldt
C
C
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001552:Benzazepines / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced; D018492:Dopamine Antagonists; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology; D017447:Receptors, Dopamine D1
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D001552:Benzazepines; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; C044846:SKF83566