Rapid and reliable induction of partial status epilepticus in naive rats by low-frequency (3-Hz) stimulation of the amygdala.
Naive rats were electrically stimulated in the amygdala with biphasic square wave pulses at 3 Hz in a model of partial status epilepticus (SE). This treatment led to the rapid kindling of seizures in all rats, and the subsequent induction of SE in 100% of rats stimulated for approximately 30-60 min. Extensive gliosis and degeneration was seen in the basal forebrain of the SE brains. This method of inducing SE is simpler, more rapid, and more reliable than similar methods reported previously.
Cain
D P
DP
Department of Psychology, University of Western Ontario, London, Canada.
McKitrick
D J
DJ
Boon
F
F
D000679:Amygdala / Q000503:physiopathology*; D000818:Animals; D004558:Electric Stimulation; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D013226:Status Epilepticus / Q000503:physiopathology*; D013997:Time Factors