Hypercalcemia in idiopathic myelofibrosis: modulation of calcium and collagen homeostasis by 1,25-dihydroxyvitamin D3.
A case of idiopathic myelofibrosis (IMF) presenting with hypercalcemia and hypercalcitriolemia is reported. It is proposed that ectopic production of the active vitamin D metabolite related to ongoing clonal expansion in the bone marrow accounts for the hypercalcemic state. Consistently low levels of circulating type I procollagen propeptide (PICP) and lack of progression of the bone marrow fibrosis during almost 6 months of follow-up point to an in vivo inhibition of type I collagen synthesis by 1,25-dihydroxyvitamin D3.
Voss
A
A
Department of Medicine, Svendborg Hospital, Denmark.
Schmidt
K
K
Hasselbalch
H
H
Junker
P
P
D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002117:Calcitriol / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood*; D003094:Collagen / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D006934:Hypercalcemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications*; D011347:Procollagen / Q000097:blood
D011347:Procollagen; D003094:Collagen; D002117:Calcitriol; D002118:Calcium; D006918:Hydroxyurea