Synthesis and anti-inflammatory activity of antioxidants, 4-alkylthio-o-anisidine derivatives.
In order to search for anti-inflammatory agents against autoimmune diseases, we synthesized 4-alkylthio-o-anisidine derivatives possessing antioxidant activity, and tested them for anti-inflammatory activity against the Arthus reaction in mice. Experimental inflammations, including the Arthus reaction, concanavalin A, phorbol ester and pyrophosphate-induced edemas in rats were inhibited by 4-propylthio-o-anisidine, which inhibited autoxidation of rat brain homogenate and suppressed the lipopolysaccharide-induced increase in the plasma malondialdehyde level in mice. An antioxidant may be an effective agent in immune complex type inflammation where active oxygen species play an important role.
Komeshima
N
N
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Osawa
T
T
Nishitoba
T
T
Jinno
Y
Y
Kiriu
T
T
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D001183:Arthus Reaction / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011919:Rats, Inbred Strains
D000814:Aniline Compounds; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; C075120:4-propylthio-2-anisidine