title: Relationship between precorneal retention of viscous eye drops and tear fluid composition.
abstract: The influence of viscolysers on the precorneal residence of a fluorescent tracer was determined, using slit lamp fluorophotometry. The solution acceptability was evaluated by the volunteers by answering a standard questionnaire. The relationship between precorneal retention of viscous eye drops, discomfort and tear fluid composition after instillation of various cellulosic solutions was examined. Irritating hydroxypropylcellulose solution increases the total protein concentration of tears, without change in the ratio of lysozyme to total protein.
authors.affiliation: University of Antwerp (UIA), Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Ludwig
authors.forename: N J
authors.initials: NJ
authors.lastname: van Haeringen
authors.forename: V M
authors.initials: VM
authors.lastname: Bodelier
authors.forename: M
authors.initials: M
authors.lastname: Van Ooteghem
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D003315:Cornea / Q000378:metabolism*; D005136:Eye Proteins / Q000032:analysis*; D019793:Fluorescein; D005452:Fluoresceins / Q000008:administration & dosage; D015590:Fluorophotometry; D006801:Humans; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D009994:Osmolar Concentration; D013500:Surface Tension; D013666:Tears / Q000737:chemistry / Q000187:drug effects; D014783:Viscosity
chemical_list: D005136:Eye Proteins; D005452:Fluoresceins; D009883:Ophthalmic Solutions; C042434:tear proteins; D065347:Hypromellose Derivatives; D002482:Cellulose; C002283:hydroxyethylcellulose; D008747:Methylcellulose; C008079:hydroxypropylcellulose; D019793:Fluorescein