[Targeting cancer chemotherapy using temperature-sensitive liposomes containing adriamycin conjugated with monoclonal antibodies].
Liposomes have a specific liquid-crystalline phase transition temperature (Tc), at which they release an entrapped drug. Temperature-sensitive liposomes containing adriamycin (TS-Lip-ADM) were made of dipalmitoylphosphatidylcholine (DPPC, Tc: 41 degrees C), distearoylphosphatidylcholine (DSPC, Tc: 54 degrees C), cholesterol and adriamycin. Monoclonal antibodies against human alpha-fetoprotein (AFP) were conjugated to TS-Lip-ADM. When liposomal suspension was immersed in a bath, the release rate of ADM from TS-Lip-ADM = Ab increased, as the temperature increased from 34 degrees C to 42 degrees C. ADM release was dependent on the temperature.
Shibata
S
S
Dept. of Surgery, School of Medicine, Keio University.
Kumai
K
K
Takahashi
T
T
Murayama
Y
Y
Ishibiki
K
K
Kitajima
M
M
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D006801:Humans; D006979:Hyperthermia, Induced; D000922:Immunotoxins / Q000627:therapeutic use*; D008081:Liposomes
D000911:Antibodies, Monoclonal; D004337:Drug Carriers; D000922:Immunotoxins; D008081:Liposomes; D004317:Doxorubicin