Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac-1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA-1.
The alpha 5 beta 1, alpha 6 beta 4 and Mac-1 integrins all participate in the endocytotic cycle. By contrast, alpha 3 beta 1, alpha 4 beta 1 and LFA-1 do so much more slowly, or not at all, in the cell lines examined. This indicates that the alpha-chains appear to determine whether an integrin cycles or not, and that alpha 5 beta 1, alpha 6 beta 4 and Mac-1 can be brought to the leading edge of a moving cell by endocytosis and recycling.
Bretscher
M S
MS
Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK.
D000818:Animals; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D004705:Endocytosis; D005353:Fibronectins / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000032:analysis / Q000502:physiology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000032:analysis; D016177:Macrophage-1 Antigen / Q000032:analysis / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic / Q000032:analysis / Q000502:physiology*
D005353:Fibronectins; D016023:Integrins; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; D017469:Receptors, Fibronectin; D011971:Receptors, Immunologic