[Evaluation of cerebrospinal fluid proteins in patients with subacute sclerosing panencephalitis (SSPE)].
CSF proteins of 62 patients with SSPE aged 6 to 26 years were analysed by polyacrylamide gel electrophoresis. The total IgG concentration in the CSF was increased to 16.8 +/- 10 mg/dl and the IgG index was raised to from 2.7 +/- 0.5 to 3.6 +/- 3.0. All SSPE patients had pathological subfractions gamma 4 and gamma 5. The per cent proportion of the gamma 1 subfraction was raised only in the youngest patients. A tendency was observed for higher values of the prealbumin:albumin index and the prealbumin: transferrin index. The youngest SSPE patients had a tendency for greater total protein concentration, lower prealbumin concentration, and highest IgG index values (3.6 +/- 3.0). In early disease period a tendency was noted for higher concentration of total protein, higher total IgG level and higher IgG index. These results suggest that SSPE patients have a constant stimulation of B-cells and variable increase of blood-brain barrier permeability.
Rosnowska
M
M
Zakładu Biochemii Kierownik, Klinik Diagnostyki i Terapii Chorób Układu Nerwowego Instytutu Psychiatrii i Neurologii w Warszawie.
Sobczyk
W
W
Cendrowski
W
W
Karkowska
B
B
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000418:Albumins / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000134:cerebrospinal fluid*; D002648:Child; D004591:Electrophoresis, Polyacrylamide Gel; D005916:Globulins / Q000134:cerebrospinal fluid; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D011228:Prealbumin / Q000134:cerebrospinal fluid; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid*; D014168:Transferrin / Q000134:cerebrospinal fluid
D000418:Albumins; D002556:Cerebrospinal Fluid Proteins; D005916:Globulins; D007074:Immunoglobulin G; D011228:Prealbumin; D014168:Transferrin
Ocena białek płynu mózgowo-rdzeniowego u chorych na podostre stwardniejace zapalenie mózgu (SSPE).