5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a new class of monoamine oxidase-B inactivators.
Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids. Both compounds were found to be irreversible inactivators of monoamine oxidase B. These compounds constitute the first members of a new class of monoamine oxidase inactivators.
Ding
Z
Z
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113.
Silverman
R B
RB
D000818:Animals; D002417:Cattle; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D007700:Kinetics; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D008744:Methylamines / Q000138:chemical synthesis / Q000494:pharmacology; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism
D005663:Furans; D007783:Lactones; D008744:Methylamines; D008996:Monoamine Oxidase Inhibitors