Chronic treatment with phosphatidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain.
Chronic treatment (21 days) with phosphatidylserine (BC-PS) partially restored the reduced density of muscarinic cholinergic receptors in several regions of the aged (18 months) mouse brain. The effect was similar whether 3H-QNB or 3H-NMS was used as radioligand. The affinity of both radioligands was not altered by BC-PS treatment. Similar treatment of young (3 months) animals was without any effect on muscarinic cholinergic receptor density in all brain regions investigated. The effect was dose-dependent with elevations of receptor density between 15 and 28% for daily IP doses between 10 and 40 mg/kg, respectively. Similar treatment of aged mice with phosphatidylcholine (40 mg/kg) was without any effect. The data give further evidence that chronic treatment of aged animals with BC-PS reverses a variety of aged-related deficits of brain function.
Gelbmann
C M
CM
Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, FRG.
Müller
W E
WE
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects; D007700:Kinetics; D008560:Membrane Fluidity / Q000187:drug effects; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D010718:Phosphatidylserines / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate; D011976:Receptors, Muscarinic / Q000187:drug effects*
D010718:Phosphatidylserines; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate