Experimental otitis media evaluated by magnetic resonance imaging: an in vivo model.
The use of magnetic resonance imaging in otitis media research is being explored in our laboratory. In this study, we present a new method for studying changes in the middle ear cleft due to an episode of induced otitis media in the chinchilla model. It uses gadolinium-diethylenetriamine pentaacetic acid, a magnetic resonance imaging contrast agent, to examine the uptake and washout characteristics of middle ear mucosa during an inflammatory episode. Parameters such as the time to maximum intensity of the mucosa and the washout rate of the contrast agent from the mucosa were significantly correlated to the duration of the infection.
Chan
K H
KH
Department of Otolaryngology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania.
Swarts
J D
JD
Hashida
Y
Y
Doyle
W J
WJ
Kardatzke
D
D
Wolf
G L
GL
D000818:Animals; D002415:Cats; D002682:Chinchilla; D003287:Contrast Media; D004195:Disease Models, Animal; D005260:Female; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D010033:Otitis Media / Q000175:diagnosis*; D004369:Pentetic Acid
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA