title: [Dysautonomia and multi-systemic atrophy of the nervous system (Shy-Drager's syndrome)].
abstract: The clinical expressions of primary autonomic nervous system failure are more or less numerous, orthostatic hypotension being only one of them. Clinical analysis reveals 3 categories of manifestations: pure progressive dysautonomia, dysautonomia associated with Parkinson's disease, and dysautonomia associated with multiple system atrophy of the nervous system also known as Shy-Drager syndrome. Neuropathological studies show that lesions of the efferent autonomic nervous system (tractus intermediolateralis, sympathetic ganglia) are frequently associated with lesions of the central nervous system the role of which in dysautonomia is still imperfectly known. Lesions of the central nervous system may present as genuine Parkinson's disease with Lew bodies or as multiple systemic atrophy with its two best individualized aspects: striatonigral atrophy and olivopontocerebellar atrophy. These various neurological aspects have their counterpart in biochemical abnormalities, prognosis and response to treatment.
authors.affiliation: Clinique Neurologique, Hôpital Beaujon, Clichy.
authors.forename: C
authors.initials: C
authors.lastname: Masson
mesh_terms: D000368:Aged; D001004:Anus Diseases / Q000209:etiology*; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology* / Q000628:therapy; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D012791:Shy-Drager Syndrome / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D013997:Time Factors; D001745:Urinary Bladder Diseases / Q000209:etiology; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents; D007980:Levodopa; D005438:Fludrocortisone
vernacular_title: Dysautonomie et atrophie multisystématisée du système nerveux (syndrome de Shy-Drager).