Serotonergic aspects of the response of human platelets to immune-adjuvant muramyl dipeptide.
The human platelet serotonergic responses of aggregation and uptake were shown to be modulated by muramyl peptides. Muramyl dipeptide inhibited serotonin uptake in a temperature dependent and stereospecific manner. It also blocked the binding to platelets of [3H]imipramine, a well-known inhibitor of serotonin uptake. Muramyl dipeptide decreased serotonin2 (5-HT2) mediated platelet aggregation, and blocked the binding of a 5-HT2-specific ligand: lysergic acid diethylamide. Since muramyl peptides are released upon degradation of bacteria, the findings offer a possible mechanism for neuro-immune modulation by emphasizing the interaction between 5-HT (a neurotransmitter) and muramyl peptides (immuno-adjuvants).
Polanski
M
M
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Karnovsky
M L
ML
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002352:Carrier Proteins / Q000097:blood / Q000378:metabolism; D006801:Humans; D007099:Imipramine / Q000378:metabolism; D007650:Ketanserin / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D017374:Paroxetine; D010880:Piperidines / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000378:metabolism
D000276:Adjuvants, Immunologic; D002352:Carrier Proteins; D010880:Piperidines; D010975:Platelet Aggregation Inhibitors; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C025366:serotonin-binding protein; D012701:Serotonin; D017374:Paroxetine; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000244:Adenosine Diphosphate; D008238:Lysergic Acid Diethylamide; D007650:Ketanserin; D007099:Imipramine