[Evaluation of intraoperative intraperitoneal administration on anti-cancer drug for gastric cancer].
This study was undertaken in order to evaluate the effect of intraoperative intraperitoneal (IP) administration of cisplatin (CDDP) and/or mitomycin C (MMC) on patients who underwent an operation for gastric cancer, compared with an untreated group. There were no differences between the effect of CDDP and that of MMC. No differences were found between the survival rate of IP and untreated group in no liver and no peritoneal metastasis cases, nor in non-resection cases. However, the median survival time was longer at 377 days in IP group than at 213 days in the untreated group (p less than 0.1). The free CDDP levels in the serum after 50 mg IP injection remained effective for 15-30 min. On the other hand, the MMC levels in the serum after 20 mg IP proved in effective.
Kosaka
T
T
2nd Dept. of Surgery, Kanazawa Medical University.
Hirano
K
K
Takegawa
S
S
Kitabayashi
K
K
Gotoda
H
H
Akiyama
T
T
Kiriyama
M
M
Saito
H
H
Tomita
F
F
Kita
I
I
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005743:Gastrectomy; D006801:Humans; D007263:Infusions, Parenteral; D007430:Intraoperative Care; D008207:Lymphatic Metastasis; D016685:Mitomycin / Q000008:administration & dosage; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
D016685:Mitomycin; D002945:Cisplatin