Effects of timolol ophthalmic solution on the intra-ocular pressure rise induced by suxamethonium and tracheal intubation.
Thirty patients received topical application of either timolol ophthalmic solution 0.25%, or normal saline, 2 h before elective ophthalmic surgery in a double-blind study. The responses to suxamethonium and tracheal intubation were compared by measuring intra-ocular pressure before induction of anaesthesia, 1 min after administration of thiopentone 2-4 mg.kg-1, 1 min after administration of suxamethonium 1 mg.kg-1, and 1, 2.5 and 5 min after tracheal intubation. There was no significant difference between the groups.
Bricker
S R
SR
St. Paul's Eye Hospital, Liverpool.
McGalliard
J N
JN
Mercer
N P
NP
Smith
G T
GT
Trimble
R B
RB
Mostafa
S M
SM
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008875:Middle Aged; D009798:Ocular Hypertension / Q000209:etiology / Q000517:prevention & control*; D009883:Ophthalmic Solutions; D013508:Ophthalmologic Surgical Procedures; D011292:Premedication; D013390:Succinylcholine / Q000009:adverse effects*; D013999:Timolol / Q000008:administration & dosage / Q000627:therapeutic use*
D009883:Ophthalmic Solutions; D013999:Timolol; D013390:Succinylcholine