title: Salvage surgery plus androgen deprivation for radioresistant prostatic adenocarcinoma.
abstract: We report on 34 patients with persistent local radiation resistant prostate cancer who underwent salvage surgical resection and hormonal deprivation. Initially, salvage prostatectomy was done in 11 patients but in 1 disease recurred locally and cystectomy was performed, for a total of 24 patients undergoing cystoprostatectomy. There were no postoperative complications in the prostatectomy group and the average postoperative stay was 7.6 days (range 6 to 12 days). Of 11 patients 4 (36%) are completely continent. There were 2 complications in the cystoprostatectomy group (1 small bowel obstruction and 1 prolonged ileus). The average postoperative stay without complication was 11 days (range 7 to 16 days). Of the 34 patients 24 (71%) are alive without radiographic evidence of disease, including 2 with detectable prostate specific antigen values at a mean of 53 months after surgery (range 25 to 93 months). Of the patients 3 (9%) are alive with radiographically evident recurrent disease (mean 53 months, range 49 to 77 months) and 7 (21%) are dead of disease (mean 52 months, range 20 to 120 months).
authors.affiliation: Department of Urology, City of Hope National Medical Center, Duarte, California.
authors.forename: T E
authors.initials: TE
authors.lastname: Ahlering
authors.forename: G
authors.initials: G
authors.lastname: Lieskovsky
authors.forename: D G
authors.initials: DG
authors.lastname: Skinner
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy / Q000601:surgery* / Q000628:therapy; D000368:Aged; D000728:Androgens / Q000502:physiology*; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000532:radiotherapy / Q000601:surgery* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000532:radiotherapy / Q000601:surgery* / Q000628:therapy; D016879:Salvage Therapy
chemical_list: D000728:Androgens