Concurrent adrenocortical carcinoma and Conn's adenoma in a man with primary hyperaldosteronism. In vivo and in vitro studies.
This is a report of a rare and unusual case of adrenal pathology. A patient presented with clinical and biological signs of primary aldosteronism and computed body tomography scan led to our suspecting the presence of a left adrenocortical carcinoma. The in vitro studies performed on the resected tumour showed very low synthesis of mineralocorticoids and glucocorticoids. The patient could not be reexamined until 15 months later, when he still suffered hypertension; another tomography scan revealed a mass on the right adrenal gland. The studies performed on this second tumour confirmed the diagnosis of Conn's adenoma: active in vitro biosynthesis of 18-hydroxy-corticosterone and aldosterone from exogenous tritiated precursors.
Touitou
Y
Y
Biochemical Department, Faculté de Médecine, Paris, France.
Boissonnas
A
A
Bogdan
A
A
Auzéby
A
A
D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D000328:Adult; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008901:Mineralocorticoids / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D005938:Glucocorticoids; D008901:Mineralocorticoids