title: Is the follicular dendritic cell a primarily stationary cell?
abstract: The cell nature of follicular dendritic cells (FDC), a member of dendritic cell group, was examined to see whether or not they are recirculating cells on splenic implantation study. Slices of BALB/c mouse spleen were implanted into C57BL/6 mice neonatally thymectomized and reconstructed by F1 (BALB/c x C57BL/6) thymus grafting. On H-2 class I immunohistology 6 months later, host spleens consisted of only the cells including FDC of host (C57BL/6) type. On the other hand, FDC of regenerated splenic grafts were of splenic donor (BALB/c) origin and haematogenic cells including germinal centre lymphocytes were of the host (C57BL/6) origin. The fact that the FDC in the regenerated splenic grafts reside irrespective of the replacement by host recirculating cells indicates that FDC belong primarily to stationary cell populations but not recirculating cell populations.
authors.affiliation: Second Department of Pathology, National Defense Medical College, Tokorozawa, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Imazeki
authors.forename: A
authors.initials: A
authors.lastname: Senoo
authors.forename: Y
authors.initials: Y
authors.lastname: Fuse
mesh_terms: D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000637:transplantation; D014184:Transplantation, Homologous