title: Importance of dynamic properties of idiotopes in interactions with anti-Id antibodies.
abstract: The concept of fluctuating conformational substates in equilibrium characterizing variable-regions of immunoglobulin idiotypes is discussed in terms of the dynamic properties of idiotopes and their stabilization upon interactions with anti-idiotope antibodies. Uniquely, polyclonal anti-Id antibodies are viewed in cooperative immobilizing interactions with the idiotopes thereby facilitating formation of stable complexes.
authors.affiliation: Department of Microbiology, University of Illinois, Urbana 61801.
authors.forename: E W
authors.initials: EW
authors.lastname: Voss
authors.forename: K M
authors.initials: KM
authors.lastname: Weidner
authors.forename: L K
authors.initials: LK
authors.lastname: Denzin
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000911:Antibodies, Monoclonal; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007147:Immunoglobulin Light Chains / Q000276:immunology; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D007143:Immunoglobulin Heavy Chains; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains