title: Anticoccidial efficacy of semduramicin in battery studies with laboratory isolates of coccidia.
abstract: The anticoccidial activity of semduramicin against laboratory isolates of five species of poultry Eimeria was investigated. In laboratory scale battery trials, semduramicin at 20 to 30 ppm demonstrated broad-spectrum anticoccidial efficacy equivalent to salinomycin at 60 ppm. Also, semduramicin at 25 ppm was fed to uninfected cockerels in batteries for 21 days, and growth rate and feed efficiency were found to be equivalent to birds fed salinomycin at 60 ppm. Semduramicin was well tolerated when coadministered with tiamulin. Semduramicin demonstrated the same activity whether produced by semisynthesis or by direct fermentation.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: A P
authors.initials: AP
authors.lastname: Ricketts
authors.forename: E A
authors.initials: EA
authors.lastname: Glazer
authors.forename: T T
authors.initials: TT
authors.lastname: Migaki
authors.forename: J A
authors.initials: JA
authors.lastname: Olson
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D004224:Diterpenes / Q000494:pharmacology / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use; D016786:Eimeria tenella / Q000187:drug effects*; D007476:Ionophores / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009550:Nigericin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D011201:Poultry Diseases / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D007476:Ionophores; C014224:tiamulin; C072941:semduramicin; D009550:Nigericin