Clonal elimination of self reactive V beta 6+ T cells induced by H-2 products expressed on thymic radio-resistant components.
The role of thymic radio-resistant cells on clonal elimination of V beta 6+ T cells that are reactive to minor lymphocyte stimulatory (Mls)-1a plus I-E antigens has been investigated. Previous studies with allogeneic bone marrow chimeras revealed that radio-sensitive I-E+ cells derived from donor bone marrow in the thymus play a major role in the clonal elimination of V beta 6+ T cells. However, we could show that not only the thymic bone marrow derived components but also the radio-resistant ones (presumably thymic epithelial cells) might be involved in induction of clonal elimination of the self-reactive T cells. The proportion of V beta 6+ T cells present varied with the H-2 haplotype of the thymus and the cell types presenting Mls-1a products, which might be attributable to differences in the affinity of the H-2 products to T cell antigen receptors and differences in the amount of tolerogens expressed on the stromal cells.
Arase
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Institute of Immunological Science, Hokkaido University, Sapporo, Japan.
Arase
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Ogasawara
K
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Good
R A
RA
Onoè
K
K
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology; D002678:Chimera / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D007108:Immune Tolerance; D051379:Mice; D008815:Mice, Inbred Strains; D016747:Minor Lymphocyte Stimulatory Antigens; D011836:Radiation Tolerance; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology / Q000528:radiation effects; D014184:Transplantation, Homologous
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta