Gonadotropin releasing hormone agonist treatment for severe menorrhagia in patients with contraindications to surgery.
Four patients with heavy menorrhagia, severe iron-deficiency anemia and contraindications to surgery were treated with a gonadotropin-releasing hormone agonist in a depot formulation. At 2 months of therapy they were all amenorrheic, and at 6 months the hematologic values had improved markedly. Gonadotropin-releasing hormone agonists may obviate emergency surgery in patients at high surgical risk or could constitute the first line of sequential therapeutic regimens, once general health conditions have improved.
Vercellini
P
P
Department of Obstetrics and Gynecology, L. Mangiagalli, University of Milano, School of Medicine, Italy.
Ferrari
A
A
D'Alberton
A
A
Motta
T
T
Maggi
R
R
Molteni
P
P
D000328:Adult; D002064:Buserelin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000075202:Contraindications; D005260:Female; D017273:Goserelin; D006801:Humans; D007044:Hysterectomy; D008595:Menorrhagia / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged
D017273:Goserelin; D002064:Buserelin