title: Effect of chlorpromazine and haloperidol on negative contrast.
abstract: Rats shifted from 32 to 4% sucrose consume substantially less of the 4% solution than animals that have not had prior experience with the 32% sucrose. This negative contrast effect was not substantially influenced by chlorpromazine (1, 3, and 5 mg/kg) or haloperidol (0.1, 0.5, and 1.0 mg/kg). Haloperidol decreased overall lick frequency, but this decrease occurred proportionately in shifted and unshifted rats, leaving contrast intact. The benzodiazepine flurazepam (5, 10, and 20 mg/kg), included as a positive control, reduced contrast at the two highest doses. The results suggest that neuroleptics do not disrupt consummatory contrast and that dopaminergic antagonists may not influence reward relativity.
authors.affiliation: Department of Psychology, Rutgers University, New Brunswick, NJ 08903.
authors.forename: C F
authors.initials: CF
authors.lastname: Flaherty
authors.forename: H C
authors.initials: HC
authors.lastname: Becker
authors.forename: S
authors.initials: S
authors.lastname: Checke
authors.forename: G A
authors.initials: GA
authors.lastname: Rowan
authors.forename: P S
authors.initials: PS
authors.lastname: Grigson
mesh_terms: D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D003259:Consummatory Behavior / Q000187:drug effects*; D005479:Flurazepam / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule
chemical_list: D005479:Flurazepam; D006220:Haloperidol; D002746:Chlorpromazine