title: Vulvar sarcoma: a report of four cases.
abstract: The clinical profiles of four patients with primary vulvar sarcomas are presented. Two patients had leiomyosarcoma in association with pregnancy, a third patient had a leiomyosarcoma with epithelioid elements, and a fourth had alveolar rhabdomyosarcoma. The natural history of the disease in the three leiomyosarcomas (including the case with epithelioid elements) was characterized by an indolent protracted course and frequent local recurrence, followed by distant fatal metastases. The patient with alveolar rhabdomyosarcoma is alive-with-disease. Surgery, chemotherapy, and radiotherapy achieved palliation rather than cure. Pregnancy did not seem to influence the prognosis.
authors.affiliation: Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: Y N
authors.initials: YN
authors.lastname: Bakri
authors.forename: M
authors.initials: M
authors.lastname: Akhtar
authors.forename: M
authors.initials: M
authors.lastname: el-Senoussi
authors.forename: R
authors.initials: R
authors.lastname: Wierzbicki
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D012086:Reoperation; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery