title: Combined radiotherapy and surgery: local control and complications in early carcinoma of the uterine cervix--the Villejuif experience, 1975-1984.
abstract: From January 1975 to December 1984, 441 patients were treated by combined radiotherapy and surgery at the Institut Gustave Roussy (IGR) for Stage IB (288) and II (proximal) (103) carcinoma of the uterine cervix. Standard treatment consisted of pre-operative utero-vaginal brachytherapy (60 Gy) using a mould technique followed by a colpo-hysterectomy and external iliac lymphadenectomy. Overall 5 year actuarial survival for the whole population was 87% and disease-free survival 85%. Loco-regional relapse occurred in 23 patients (5%). Of these, 12 were central pelvic failures, 8 regional failures and 3 combined central and regional failures. There were 36 systemic relapses (8%) of which 12 relapsed concurrently in the pelvis. Five year actuarial pelvic disease-free, disease-free and overall survival was 87, 85 and 87%, respectively, for the whole population. 340 patients developed one or more complications [Grade 1: 198/441 (44%), Grade 2: 121/441 (27%) and Grade 3 or 4: 21/441 (4.7%)]. Five year actuarial survival for the whole population was poorer for histologically node positive than for node negative (89 vs. 55%, p less than 0.0001). Pre-operative brachytherapy followed by surgery can provide good local control with acceptable morbidity in early cervical cancer.
authors.affiliation: Institut Gustave Roussy, Villejuif, France.
authors.forename: A L
authors.initials: AL
authors.lastname: Gerbaulet
authors.forename: I H
authors.initials: IH
authors.lastname: Kunkler
authors.forename: G R
authors.initials: GR
authors.lastname: Kerr
authors.forename: C
authors.initials: C
authors.lastname: Haie
authors.forename: G
authors.initials: G
authors.lastname: Michel
authors.forename: M
authors.initials: M
authors.lastname: Prade
authors.forename: C
authors.initials: C
authors.lastname: Lhomme
authors.forename: M
authors.initials: M
authors.lastname: Masselot
authors.forename: M
authors.initials: M
authors.lastname: Albano
authors.forename: A
authors.initials: A
authors.lastname: Dutreix
mesh_terms: D003131:Combined Modality Therapy; D005260:Female; D005602:France; D006801:Humans; D009367:Neoplasm Staging; D011880:Radiotherapy Planning, Computer-Assisted; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery