title: Extrarenal sorbitol clearance after liver transplantation.
abstract: Extrarenal sorbitol clearance was measured in liver transplant patients after a steady-state perfusion. Four measurements were performed in 3 patients with various liver diseases (beginning or patent acute rejection, cytomegalovirus hepatitis, hepatic metastasis). The mean (+/- SD) extrarenal sorbitol clearance was 14.8 +/- 0.1 ml/min.kg. In 5 patients with minimal or no liver abnormalities, the mean from 5 measurements of extrarenal sorbitol clearance was 18.9 +/- 5.0 ml/min.kg. Extrarenal sorbitol clearance values in this later group were higher than the values previously reported in healthy subjects.
authors.affiliation: Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Besançon.
authors.forename: G
authors.initials: G
authors.lastname: Paintaud
authors.forename: J P
authors.initials: JP
authors.lastname: Miguet
authors.forename: S
authors.initials: S
authors.lastname: Bresson-Hadni
authors.forename: M
authors.initials: M
authors.lastname: Gillet
authors.forename: G
authors.initials: G
authors.lastname: Mantion
authors.forename: P
authors.initials: P
authors.lastname: Bechtel
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011183:Postoperative Complications / Q000378:metabolism; D011184:Postoperative Period; D013012:Sorbitol / Q000493:pharmacokinetics*
chemical_list: D013012:Sorbitol