Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XVII: Oligoamines with fluorescent properties. Part A: Fluorescent bridged nitrogen functions.
Eleven dimethanamines and one disydnonimine with fluorescent properties have been synthesized. All of them show antiplatelet activities (IC50, Born-test) in concentrations between 14-75 mumol/L. Five of them inhibited fibrin formation induced by thromboplastin by more than 75% in a 200 mu molar concentration. Both effect do not run parallel. The most space consuming fluorophores show the smallest inhibition of the platelet aggregation. Best results were obtained with an azulene, acenaphthene or naphthalene moiety between the two basic nitrogen functions.
Rehse
K
K
Institut für Pharmazie, Freien Universität Berlin.
Seidel
T
T
D000925:Anticoagulants / Q000138:chemical synthesis* / Q000494:pharmacology; D005453:Fluorescence; D006801:Humans; D066298:In Vitro Techniques; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011073:Polyamines / Q000138:chemical synthesis* / Q000494:pharmacology
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D011073:Polyamines