Renal magnesium wasting associated with acetaminophen abuse.
We report a case of magnesium deficiency associated with acetaminophen abuse. Metabolic studies showed that the patient's fractional excretion of magnesium was 12% when her serum magnesium level was 1.0 mg/dL. Renal biopsy demonstrated severe tubulointerstitial disease. The significant wasting of magnesium at a time when serum magnesium levels were depressed suggests renal magnesium wasting syndrome. This defect was temporally related to abuse of acetaminophen.
Tuso
P J
PJ
UCLA School of Medicine.
Nortman
D
D
D000082:Acetaminophen; D000368:Aged; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000097:blood / Q000209:etiology*; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000150:complications; D019966:Substance-Related Disorders / Q000150:complications*
D000082:Acetaminophen; D008274:Magnesium