Establishment of a new cell line derived from a human gliosarcoma.
A permanent cell line, GI-1, was established from a human gliosarcoma, and its characteristics were investigated. The original tumor was a mixture of two different neoplasms which had components of both glioma and sarcoma. The established cell line expressed various mesenchymal antigens, but not neuroepithelial antigens. It was noted, however, that the cell line produced tumors with the morphological features of human glioma after inoculation in athymic mice. The contrast of the pathological characteristics in tissue culture and in xenograft was unique, and this finding suggests that the GI-1 cell line may have the features of both glioma and sarcoma.
Iwasaki
K
K
Department of Neurosurgery, Kyoto University Medical School, Japan.
Kikuchi
H
H
Miyatake
S
S
Kondo
S
S
Oda
Y
Y
D000782:Aneuploidy; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002460:Cell Line; D005353:Fibronectins / Q000032:analysis; D005625:Frontal Lobe; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005910:Glioma / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007797:Laminin / Q000032:analysis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009368:Neoplasm Transplantation; D010296:Parietal Lobe; D009418:S100 Proteins / Q000032:analysis; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured / Q000737:chemistry / Q000473:pathology / Q000637:transplantation; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D014408:Biomarkers, Tumor; D005353:Fibronectins; D005904:Glial Fibrillary Acidic Protein; D007797:Laminin; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin; D014841:von Willebrand Factor