Systemic lupus erythematosus in a child receiving long-term interferon therapy.
Systemic lupus erythematosus (SLE) developed in a 10 1/2-year-old white boy with juvenile laryngeal papillomatosis who had been treated with interferon alfa-n1 for 7 years. His age, gender, and fast recovery after discontinuation of interferon therapy and institution of appropriate treatment for SLE are compatible with a diagnosis of drug-induced SLE. Autoimmune disorders may occur as a complication of interferon therapy.
Tolaymat
A
A
Department of Pediatrics, University of Florida Health Science Center, Jacksonville 32209.
Leventhal
B
B
Sakarcan
A
A
Kashima
H
H
Monteiro
C
C
D001327:Autoimmune Diseases / Q000209:etiology; D002648:Child; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D007822:Laryngeal Neoplasms / Q000628:therapy; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000276:immunology; D008297:Male; D010212:Papilloma / Q000628:therapy; D013997:Time Factors
D016898:Interferon-alpha