title: Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1.
abstract: The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the kappa B sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cis-acting negative regulatory element.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0650.
authors.forename: D M
authors.initials: DM
authors.lastname: Markovitz
authors.forename: M C
authors.initials: MC
authors.lastname: Hannibal
authors.forename: M J
authors.initials: MJ
authors.lastname: Smith
authors.forename: R
authors.initials: R
authors.lastname: Cossman
authors.forename: G J
authors.initials: GJ
authors.lastname: Nabel
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D001483:Base Sequence; D017252:CD3 Complex; D004252:DNA Mutational Analysis; D015967:Gene Expression Regulation, Viral; D016322:HIV Enhancer / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology; D008934:Mitogens / Q000494:pharmacology; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D008934:Mitogens; D016328:NF-kappa B; D011948:Receptors, Antigen, T-Cell; D014157:Transcription Factors