[Contact factors in severe sepsis].
Coagulation and fibrinolysis are not activated in an isolated system but it involves numerous interrelations with the kininogen-kinin pathway and the complement. In severe sepsis, substances released by microorganisms, notably lipopolysaccharides, can activate the contact system, and particularly in such circumstances, contact activation probably plays a role in the occurrence of haemodynamic changes and consumption coagulopathy. Evidence of kininogen-kinin pathway activation as assessed by biological investigations in patients with severe sepsis, could lead to the therapeutical use of natural or synthetic protease inhibitors.
Dosquet
C
C
Laboratoire d'Immuno-Hématologie, Hôpital Lariboisière, Paris.
Wautier
J L
JL
D001059:Apoproteins / Q000627:therapeutic use; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000502:physiology*; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D004731:Endotoxins / Q000097:blood; D015956:Factor XIIa / Q000502:physiology; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007610:Kallikreins / Q000502:physiology; D007704:Kininogens / Q000502:physiology; D018805:Sepsis / Q000097:blood* / Q000188:drug therapy
D001059:Apoproteins; D001779:Blood Coagulation Factors; D003174:Complement C1 Inactivator Proteins; D004731:Endotoxins; D007704:Kininogens; D007610:Kallikreins; D015956:Factor XIIa
Facteurs de contact au cours des états septiques graves.