Effect of energy intake on postprandial plasma hormones and triglyceride concentrations in infant female baboons (Papio species).
We previously reported that female baboons overfed during infancy were not fatter at weaning, but developed hypertrophic obesity after puberty. To clarify the mechanisms of this dietary effect on adipocyte hypertrophy, we determined the effects of infant overfeeding on preweaning plasma hormone and triglyceride levels and their relationship with fat cell volume at weaning (19 weeks of age). Newborn female baboons from 3 sires and 24 dams were fed either 280 kilojoules (normally fed; n = 12) or 395 kilojoules (overfed; n = 10) per 100 g Similac formula for 18 weeks. Both formulas contained 9.2%, 43.1%, and 48.5% of calories as protein, carbohydrate, and fat, respectively. During the first 9 weeks, overfed infants had significantly higher fasting and postprandial insulin, total T3, and free T3 concentrations; lower cortisol levels; and lower excretion of urinary 17-hydroxycorticosteroids (17-OHCS) than normally fed infants. These effects were no longer significant at 17-18 weeks. Infant diet did not influence fasting and postprandial plasma triglyceride levels, and fat cell volume was not influenced by energy intake. However, fat cell volume was positively associated with postprandial triglyceride concentrations and inversely associated with postmeal nadir cortisol levels. These results demonstrate that infant overfeeding initiates early alterations in insulin, T3, free T3, and cortisol, but these effects persist only as long as there is a significant increase in energy intake.
Lewis
D S
DS
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas 78228-0147.
Jackson
E M
EM
Mott
G E
GE
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D001827:Body Height / Q000187:drug effects; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005526:Food, Formulated; D006854:Hydrocortisone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D010215:Papio / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D015065:17-Hydroxycorticosteroids; D007328:Insulin; D013963:Thyroid Hormones; D014280:Triglycerides; D006854:Hydrocortisone