title: Synoviorthesis in young patients with hemophilia and inhibitory antibodies.
abstract: In five patients under the age of 15 with hemophilia and inhibitors, due to frequent joint bleedings, 13 joints were treated with synoviorthesis (intra-articular injection of radioactive gold). The patients received high doses of factor VIII/IX for 2-4 days or were treated simultaneously with tolerance induction according to the Malmö protocol. Of the 13 joints treated, a bleeding-free interval of more than 6 months was obtained in nine of which six remained free from bleedings for more than a year. Ease of performance, the limited requirements of pre- and postoperative care, and a definite decrease in the joint bleeding frequency render synoviorthesis well suited for use in hemophiliacs with inhibitors who are otherwise difficult to treat.
authors.affiliation: Department of Orthopaedics, University of Lund, Malmö General Hospital, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Löfqvist
authors.forename: C
authors.initials: C
authors.lastname: Petersson
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D005164:Factor IX / Q000276:immunology / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology / Q000627:therapeutic use; D006050:Gold Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D006395:Hemarthrosis / Q000209:etiology / Q000532:radiotherapy*; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006801:Humans; D007114:Immunization; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007165:Immunosuppression Therapy; D007270:Injections, Intra-Articular; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D012189:Retrospective Studies
chemical_list: D006050:Gold Radioisotopes; D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies; D003520:Cyclophosphamide; D005169:Factor VIII; D005164:Factor IX