[Selective decontamination of the intestine and total gnotobiologic isolation in treatment of mice with acute radiation sickness].
Comparative study of ciprofloxacin, pefloxacin and amikacin showed that ciprofloxacin and pefloxacin had a selective action on the intestinal microflora of conventional mice. Amikacin induced inhibition not only of the opportunistic bacteria but also of the representatives of the indigenous microflora. The use of the drugs in combination with total gnotobiological isolation in treatment of experimental radiation sickness provided an increase in survival of the irradiated animals, the more so as ciprofloxacin was used.
Romanchuk
L A
LA
Bush
V
V
Korshunov
V M
VM
D000208:Acute Disease; D000583:Amikacin / Q000627:therapeutic use; D000818:Animals; D002939:Ciprofloxacin / Q000627:therapeutic use; D003666:Decontamination / Q000379:methods*; D005856:Germ-Free Life / Q000187:drug effects*; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology; D051379:Mice; D008808:Mice, Inbred CBA; D009894:Opportunistic Infections / Q000517:prevention & control*; D015366:Pefloxacin / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000382:microbiology
D015366:Pefloxacin; D002939:Ciprofloxacin; D000583:Amikacin
Primenenie selektivnoĭ dekontaminatsii kishechnika i obshcheĭ gnotobiologicheskoĭ izoliatsii pri lechenii mysheĭ s ostroĭ luchevoĭ bolezn'iu.