title: Theoretical considerations and perspectives on the onset of action of moclobemide.
abstract: The aim of this paper is to focus on methodological problems related to clinical studies on the onset of action of antidepressants, especially moclobemide. The methodological discussion proposed focuses on: --global efficacy as a function of time; --proposals for a specific approach to the study of the onset of action; --quality of the response and onset of action; --the dimensional level and the onset of action.
authors.affiliation: F. Hoffmann-La Roche Ltd, Basel, Switzerland.
authors.forename: J P
authors.initials: JP
authors.lastname: Gachoud
authors.forename: H
authors.initials: H
authors.lastname: Mikkelsen
authors.forename: S
authors.initials: S
authors.lastname: Ammar
authors.forename: D
authors.initials: D
authors.lastname: Widlöcher
authors.forename: R
authors.initials: R
authors.lastname: Jouvent
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D020912:Moclobemide
chemical_list: D000928:Antidepressive Agents; D001549:Benzamides; D020912:Moclobemide