title: The effect of intravenous metformin on glucose metabolism during hyperglycaemia in type 2 diabetes.
abstract: A stepped intravenous metformin infusion was used in conjunction with the hyperglycaemic clamp technique to study the dose-response relationship of plasma metformin concentration with hepatic glucose production and peripheral glucose disposal in nine patients with Type 2 diabetes. The study was of double-blind crossover design, using NaCl infusion as control. Plasma metformin concentrations spanning the therapeutic range (1.64 +/- 0.13 mg l-1 and 6.57 +/- 0.61 mg l-1) were achieved. No differences in peripheral glucose disposal were demonstrated when compared with NaCl infusion (3.4 +/- 0.1 vs 3.6 +/- 0.2 (+/- SE) mg kg-1 min-1 and 3.4 +/- 0.2 vs 3.3 +/- 0.2 mg kg-1 min-1, respectively). There was also no difference in basal hepatic glucose production during metformin and NaCl infusion (2.7 +/- 0.3 vs 2.8 +/- 0.2 mg kg-1 min-1). No acute effect of metformin on hepatic glucose production or peripheral glucose disposal was observed, implying that a chronic persistent effect is more important in these respects than immediate effects consequent upon changes in plasma drug level.
authors.affiliation: Department of Medicine, University of Newcastle upon Tyne, UK.
authors.forename: C F
authors.initials: CF
authors.lastname: Sum
authors.forename: J M
authors.initials: JM
authors.lastname: Webster
authors.forename: A B
authors.initials: AB
authors.lastname: Johnson
authors.forename: C
authors.initials: C
authors.lastname: Catalano
authors.forename: B G
authors.initials: BG
authors.lastname: Cooper
authors.forename: R
authors.initials: R
authors.lastname: Taylor
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000209:etiology; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood; D008297:Male; D008687:Metformin / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008687:Metformin