title: Degeneration of the ipsilateral substantia nigra following cerebral infarction in the striatum.
abstract: OBJECTIVE
  In rats, degeneration of the ipsilateral substantia nigra occurs a few weeks after occlusion of the middle cerebral artery. The aim of this study was to clarify whether similar change is observed in stroke patients.
  
  
  METHODS
  Eighteen patients with striatal infarction and six patients with cortical infarction in the territory of the middle cerebral artery were examined by means of sequential magnetic resonance imaging.
  
  
  RESULTS
  In all patients with striatal infarction, T2-weighted images revealed a high-signal-intensity spot in the ipsilateral substantia nigra. Changes in the ipsilateral substantial nigra appeared at day 14 after stroke on average and then became less intense and smaller a few months after the stroke. By contrast, we observed no nigral changes in any patient with cortical infarction.
  
  
  CONCLUSIONS
  The degenerative change in the ipsilateral substantia nigra initially found in the rat model similarly occurred in patients with striatal infarction. This remote change in the substantia nigra may represent magnetic resonance imaging detection of neuropathologic changes in this region through the striatonigral pathway.
authors.affiliation: Department of Neurosurgery, Tokyo Metropolitan Bokuto Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakane
authors.forename: A
authors.initials: A
authors.lastname: Teraoka
authors.forename: R
authors.initials: R
authors.lastname: Asato
authors.forename: A
authors.initials: A
authors.lastname: Tamura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002544:Cerebral Infarction / Q000175:diagnosis / Q000473:pathology*; D003342:Corpus Striatum; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013378:Substantia Nigra / Q000473:pathology*