title: Distal limb deficiency following chorionic villus sampling?
abstract: We have reviewed the follow-up of almost 3000 completed pregnancies in the Münster CVS Program and identified 4 children with distal limb deficiencies. Two cases involved only minor anomalies of distal digital phalanges. One child had a Hanhart anomaly (hypoglossia hypodactylia). We also reviewed 24 cases of limb defects following CVS reported previously. With the exception of a single series, neither the overall incidence of affected children nor cases reported from larger series provide unambiguous evidence of an increased risk of distal limb deficiency caused by CVS.
authors.affiliation: Department of Human Genetics, Universitätsklinik Münster, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schloo
authors.forename: P
authors.initials: P
authors.lastname: Miny
authors.forename: W
authors.initials: W
authors.lastname: Holzgreve
authors.forename: J
authors.initials: J
authors.lastname: Horst
authors.forename: W
authors.initials: W
authors.lastname: Lenz
mesh_terms: D002675:Child, Preschool; D015193:Chorionic Villi Sampling / Q000009:adverse effects* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D017880:Limb Deformities, Congenital; D011247:Pregnancy; D011261:Pregnancy Trimester, First