Midazolam sedation reversed with flumazenil for cardioversion.
Midazolam was used for anaesthesia in 20 patients undergoing cardioversion; 10 received flumazenil, which caused immediate rapid reversal of anaesthesia, and these patients maintained SpO2 greater than 95%, breathing air, within 5-10 min. In contrast, patients in the placebo group were still partially sedated and required oxygen therapy for up to 2 h to maintain a normal SpO2. Arterial pressure, but not heart rate, also was greater in the flumazenil group in the recovery period.
Fennelly
M E
ME
Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Powell
H
H
Galletly
D C
DC
Whitwam
J G
JG
D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001145:Arrhythmias, Cardiac / Q000628:therapy; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004554:Electric Countershock; D005442:Flumazenil / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008874:Midazolam / Q000037:antagonists & inhibitors*; D008875:Middle Aged
D005442:Flumazenil; D008874:Midazolam