[Epithelial membrane antigen in lymphosarcoma cells (immunomorphologic study)].
11 cases of different types of lymphosarcoma of T- and B-nature are studied immunohistochemically by means of antibodies against epithelial membrane antigen (EMA), including new Soviet monoclonal antibodies ICO-25 to this antigen, common leucocytic antigen, vimentin and cytokeratin. The phenomenon of the EMA including ICO-25 binding to the cells of some lymphosarcomas is confirmed. This indicates that the use of only this "epithelial differentiation marker" in not sufficient for the differentiation between lymphosarcoma and poorly differentiated carcinoma. Variability of lymphosarcoma cells staining by vimentin antibodies is shown, other limitations of the immunohistochemical examination of lymphoma are discussed. The conclusion is made of the necessity to use the spectrum of the above antibodies when differentiating between lymphosarcoma and poorly differentiated carcinoma.
Smirnov
A V
AV
Probatova
N A
NA
Sholokhova
E N
EN
Petsko
A A
AA
D000943:Antigens, Differentiation / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis*; D002277:Carcinoma / Q000175:diagnosis / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D008562:Membrane Glycoproteins / Q000032:analysis*; D018396:Mucin-1
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; D018396:Mucin-1
Epitelial'nyĭ membrannyĭ antigen v kletkakh limfosarkom (immunomorfologicheskoe issledovanie).