Deletion of chromosome 6q in two cases of acute myeloblastic leukemia and a review of the literature.
Two cases of acute myeloblastic leukemia (AML M2) associated with a deletion of chromosome 6q are described. One was a 38-year-old man with constitutional inversion of chromosome 9, and another was a 57-year-old female atomic-bomb survivor. The karyotype of these patients were 46,XY,del(6)(q12q14),inv(9)(p11q13), and 47,XX,6q-,+min, respectively. In both cases c-myb protooncogene, which is located in chromosome 6q, was neither deleted nor rearranged, and c-myb messenger RNA level was not elevated. These results suggest that c-myb is not involved in the leukemogenesis of AML with 6q- as well as lymphoid malignancies with 6q-. Out of 23 AML cases with 6q- reviewed, 6 cases had erythroleukemia, and 4 developed in Down syndrome patients.
Hirata
J
J
Department of Clinical Laboratory, Kyushu University Hospital, Fukuoka, Japan.
Abe
Y
Y
Taguchi
F
F
Takatsuki
H
H
Nishimura
J
J
Nawata
H
H
D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009857:Oncogenes
D004273:DNA, Neoplasm