title: [Late hemorrhagic disease in newborn infants. Is the current preventive treatment with oral vitamin K adequate?].
abstract: During recent years, we have observed two cases of haemorrhage due to vitamin K deficiency which developed late in the neonatal period. One patient was a female infant aged six weeks with severe intracranial bleeding and the other was a female infant aged three weeks with marked haemorrhage from the umbilicus. Both of these infants were entirely breast-fed and had received vitamin K (1 mg fytomenadion) orally at birth. Both infants had unrecognized alfa-1-antitrypsin deficiency with liver involvement. In other European countries, many cases of late haemorrhagic disease of the newborn due to vitamin K deficiency have been registered in infants who had received oral vitamin K prophylaxis. On the basis of these observations and investigations which suggest that oral vitamin K prophylaxis is not so effective as intramuscular administration, it is suggested that the present oral vitamin K prophylaxis should be altered.
authors.affiliation: Børneafdelingen, Aalborg Sygehus.
authors.forename: K N
authors.initials: KN
authors.lastname: Hansen
authors.forename: L
authors.initials: L
authors.lastname: Tegllund
authors.forename: A
authors.initials: A
authors.lastname: Lange
authors.forename: F
authors.initials: F
authors.lastname: Ebbesen
mesh_terms: D000284:Administration, Oral; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011859:Radiography; D014472:Umbilicus / Q000098:blood supply; D014812:Vitamin K / Q000008:administration & dosage*; D014813:Vitamin K Deficiency / Q000150:complications / Q000517:prevention & control*; D006475:Vitamin K Deficiency Bleeding / Q000209:etiology / Q000517:prevention & control*
chemical_list: D014812:Vitamin K
vernacular_title: Sen haemoragisk sygdom hos nyfødte. Er den nuvoerende perorale K-vitaminprofylakse tilstroekkelig?