title: c-myc over-expression in human primary ovarian tumours: its relevance to tumour progression.
abstract: Expression of the c-myc gene was analyzed in 56 human primary ovarian cancer tissues, including 51 common epithelial and 5 non-epithelial tumours to determine molecular events in the carcinogenic process in ovaries. Over-expression of the c-myc gene was found in 37.3% of all ovarian tumour tissues, and in 63.5% of serous adenocarcinoma tissues. Significant over-expression of the c-myc gene at Stage III compared with other stages, and one remarkable case of over-expression in a serous tumour of low malignant potential suggest that c-myc expression is temporarily activated at some stage(s) during tumorigenesis of ovarian cancer, especially of serous tumours.
authors.affiliation: Department of Obstetrics and Gynecology, Kumamoto University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tashiro
authors.forename: K
authors.initials: K
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Okamura
authors.forename: A
authors.initials: A
authors.lastname: Iwai
authors.forename: M
authors.initials: M
authors.lastname: Fukumoto
mesh_terms: D005260:Female; D015870:Gene Expression; D016259:Genes, myc; D006801:Humans; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology