Autoimmune hemolytic anemia associated with anti-Sc1.
A case of autoimmune hemolytic anemia (AIHA) in a young child is described. The hemolysis was resistant to steroid therapy but responded to splenectomy and intravenous immunoglobulin. The autoantibody was shown to be anti-Sc1 by both serologic and immunoblotting techniques. This seems to be the first report of an autoanti-Sc1 detected by immunoblotting and the first example of AIHA in a child caused by autoanti-Sc1.
Owen
I
I
Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Chowdhury
V
V
Reid
M E
ME
Poole
J
J
Marsh
J C
JC
Hows
J M
JM
D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D017411:Ribonucleoproteins, Small Nuclear; D013156:Splenectomy; D055517:snRNP Core Proteins
D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins