title: Enoximone in newborns with refractory postoperative low-output states (LOS).
abstract: Enoximone was administered to 16 newborns with postoperative, catecholamine-refractory cardiac low-output states in addition to high-dose catecholamine treatment. Haemodynamic changes were assessed at baseline and during treatment. Haemodynamic parameters were improved in 12 newborns ("responders"), 9 of these survived. Three responders died; one from cardiac low-output and 2 from uncorrectable congenital heart disease verified by autopsy. Four newborns did not respond to enoximone therapy ("non-responders") and died. The haemodynamic effects of enoximone were characterized by an increase in cardiac index (+160%, P less than 0.0008), and a fall in right (-26%, P less than 0.0004) and left (-34%, P less than 0.003) atrial pressures. It is concluded that enoximone can be an effective agent in the treatment of cardiac low-output states refractory to high-dose catecholamines in neonates up to 7 months old.
authors.affiliation: German Heart Center, Berlin.
authors.forename: G
authors.initials: G
authors.lastname: Hausdorf
authors.forename: N
authors.initials: N
authors.lastname: Friedel
authors.forename: F
authors.initials: F
authors.lastname: Berdjis
authors.forename: H A
authors.initials: HA
authors.lastname: Dieterich
authors.forename: J J
authors.initials: JJ
authors.lastname: Fell
authors.forename: H T
authors.initials: HT
authors.lastname: Dressler
authors.forename: A
authors.initials: A
authors.lastname: Werneyer
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
authors.forename: P E
authors.initials: PE
authors.lastname: Lange
mesh_terms: D002303:Cardiac Output, Low / Q000188:drug therapy* / Q000209:etiology; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017335:Enoximone; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D011183:Postoperative Complications
chemical_list: D002316:Cardiotonic Agents; D007093:Imidazoles; D017335:Enoximone