Biochemical ethanol effects affected by a non-steroidal anti-inflammatory drug.
The non-steroidal anti-inflammatory drug, piroxicam, prevents the hepatic increase of triacylglycerols and malondialdehyde resulting from the acute intoxication of rats with ethanol. In addition, in the intoxicated rats, piroxicam consistently produces a decrease in the levels of blood ethanol in comparison with control animals. It is suggested that the anti-inflammatory compound stimulates ethanol oxidation.
Zentella de Piña
M
M
Depto. de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, D.F.
Hernández-Tobías
A
A
Saldaña-Balmori
Y
Y
Díaz-Belmont
A
A
Piña
E
E
D000818:Animals; D000431:Ethanol / Q000037:antagonists & inhibitors*; D007700:Kinetics; D015227:Lipid Peroxidation; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010894:Piroxicam / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D010894:Piroxicam; D000431:Ethanol