Possible participation of endogenous opioid peptides on the mechanism involved in analgesia induced by vouacapan.
The involvement of opioid peptides in the mechanism of action of vouacapan, a new experimental compound extracted from seeds of Pterodon poligalaeflorus Benth, was investigated both in mice utilizing acetic acid writhing response and in rats utilizing inflammatory hyperalgesia induced by carrageenan and modified Randall-Selitto method. Vouacapan, in both models, caused a dose-dependent analgesia when injected p.o., s.c. and i.p. The analgesic effect was partially blocked by naloxone, nalorphine and n-methyl-nalorphine. Significant tolerance to analgesic effect was observed following repeated administration of vouacapan or morphine. On the last day of treatment, cross administration revealed symmetrical and asymmetrical cross-tolerance between vouacapan and morphine, in rats and mice, respectively. We conclude that a release of endorphins could be involved in the analgesic mechanism of vouacapan in both models tudied.
Duarte
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ID
Department of Pharmacology, UFMG, Belo Horizonte, Brasil.
Ferreira-Alves
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DL
Nakamura-Craig
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M
D000700:Analgesics / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D000818:Animals; D004224:Diterpenes / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D004333:Drug Administration Routes; D004361:Drug Tolerance; D004723:Endorphins / Q000502:physiology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage; D009269:Nalorphine / Q000031:analogs & derivatives / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D004224:Diterpenes; D004723:Endorphins; D009270:Naloxone; C073437:vouacapan; D009020:Morphine; D009269:Nalorphine