title: Genes for tryptophan biosynthesis in the halophilic archaebacterium Haloferax volcanii: the trpDFEG cluster.
abstract: Tryptophan auxotrophs of the archaebacterium Haloferax volcanii define a cluster of overlapping genes homologous to eubacterial-eukaryotic trpD, -F, -E, and -G, linked in that order and each preceded by a possible ribosome binding site. Residues involved in feedback inhibition of eubacterial anthranilate synthetases are conserved.
authors.affiliation: Canadian Institute for Advanced Research, Dalhousie University, Halifax, Nova Scotia.
authors.forename: W L
authors.initials: WL
authors.lastname: Lam
authors.forename: S M
authors.initials: SM
authors.lastname: Logan
authors.forename: W F
authors.initials: WF
authors.lastname: Doolittle
mesh_terms: D019747:Aldose-Ketose Isomerases; D000595:Amino Acid Sequence; D000877:Anthranilate Phosphoribosyltransferase / Q000235:genetics; D000878:Anthranilate Synthase / Q000235:genetics; D001483:Base Sequence; D002238:Carbohydrate Epimerases / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000235:genetics*; D006216:Halobacteriaceae / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D014364:Tryptophan / Q000378:metabolism*
chemical_list: D014364:Tryptophan; D000877:Anthranilate Phosphoribosyltransferase; D000878:Anthranilate Synthase; D002238:Carbohydrate Epimerases; D019747:Aldose-Ketose Isomerases; C029865:phosphoribosylanthranilate isomerase