Transmission of toxoplasmosis by bone marrow transplant associated with Campath-1G.
A 12-year-old boy in third remission acute lymphoblastic leukaemia was given a mismatched transplant from his mother. He suffered prolonged neutropenia and pyrexia which was only finally diagnosed as toxoplasmosis using molecular biology methods and by his response to appropriate treatment. This was probably transmitted by bone marrow transplant since maternal immune T cells were removed by the use of Campath-1G and treatment with cyclosporin A probably prevented his IgM immune response and impeded the diagnosis.
Jurges
E
E
Westminster Bone Marrow Team, Westminster Children's Hospital, London, UK.
Young
Y
Y
Eltumi
M
M
Holliman
R E
RE
Vellodi
A
A
Rogers
T R
TR
Hobbs
J R
JR
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D000074301:CD52 Antigen; D002648:Child; D006023:Glycoproteins; D006801:Humans; D008212:Lymphocyte Depletion / Q000009:adverse effects; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology; D014123:Toxoplasmosis / Q000635:transmission*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D006023:Glycoproteins