Antifungal activities of salivary histidine-rich polypeptides against Candida albicans and other oral yeast isolates.
Twenty-six oral yeast isolates from 26 donors were tested for their susceptibility to salivary histidine-rich polypeptide-4 (HRP-4) in blastospore viability assays. HRP-4 was observed to inhibit blastospore division in all of the yeast isolates, although inhibition was variable depending upon both species and strain tested. Nine species of Candida and 2 strains of Trichosporon pullulans were included in the study. No significant differences in susceptibility to HRP-4 could be seen, irrespective of where in the oral cavity the yeast isolate was obtained.
Rayhan
R
R
School of Dental Medicine, State University of New York at Stony Brook.
Xu
L
L
Santarpia
R P
RP
Tylenda
C A
CA
Pollock
J J
JJ
D000935:Antifungal Agents / Q000494:pharmacology; D002175:Candida / Q000187:drug effects / Q000254:growth & development*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D011506:Proteins / Q000502:physiology*; D012463:Saliva / Q000382:microbiology / Q000502:physiology; D012471:Salivary Proteins and Peptides / Q000502:physiology*; D013172:Spores, Fungal / Q000187:drug effects; D014250:Trichosporon / Q000187:drug effects / Q000254:growth & development; D000099053:Histidine-Rich Glycoprotein
D000935:Antifungal Agents; D011506:Proteins; D012471:Salivary Proteins and Peptides; D000099053:Histidine-Rich Glycoprotein