Analyses of plasma for metabolic and hormonal changes in rats flown aboard COSMOS 2044.
Plasma samples from rats flown aboard COS-MOS 2044 were analyzed for the levels of key metabolites, electrolytes, enzymes, and hormones. The major differences between the flight group and the synchronous control were elevations in glucose, cholesterol, phosphate, creatinine, blood urea nitrogen, lactate dehydrogenase, and aspartate amino-transferase and decreased levels of thyroxine. Most of these differences were not mimicked by tail suspension of ground-based rats; however, both flight and suspended rats exhibited inhibited testosterone secretion. Corticosterone, immunoreactive growth hormone, and prolactin showed inconsistent differences from the various control groups, suggesting that the levels of these hormones were not due to actual or simulated microgravity.
Merrill
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AH
Department of Biochemistry, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322.
Wang
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Mullins
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Grindeland
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Popova
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IA
D000311:Adrenal Glands / Q000502:physiology; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004573:Electrolytes / Q000097:blood; D004798:Enzymes / Q000097:blood; D006728:Hormones / Q000097:blood*; D008297:Male; D009929:Organ Size / Q000502:physiology; D010949:Plasma / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D013737:Testis / Q000502:physiology
D001798:Blood Proteins; D004573:Electrolytes; D004798:Enzymes; D006728:Hormones