title: Ketamine abolishes the tonic phase of the seizures evoked by sudden cooling of toad isolated spinal cords.
abstract: Spinal seizures evoked by sudden cooling (SSSC) were used to investigate the anticonvulsant activity of ketamine (KET) injected either intralymphatically (i.l., 5-40 mg/kg) or intrathecally (i.t., 0.5-1.0 mumol/20 microliters) using isolated spinal cord-hindleg preparation. KET inhibited the tonic phase and prolonged the clonic phase in a dose-dependent manner. The cionic phase was depressed or totally blocked at KET doses of 80-160 mg/kg, i.l. or 2 mumol/20 microliters, i.t. This depression was not prevented by i.t. administration of concanavalin A. The latency of onset of seizures was also increased by KET. KET abolishes the tonic-extensor phase of SSSC in which activation of N-methyl-D-aspartate-receptors may play a role.
authors.affiliation: Universidad Centroccidental Lisandro Alvarado, Escuela de Ciencias Veterinarias, Barquisimeto, Venezuela.
authors.forename: N L
authors.initials: NL
authors.lastname: Daló
authors.forename: J C
authors.initials: JC
authors.lastname: Piña-Crespo
mesh_terms: D000818:Animals; D002024:Bufo marinus; D003080:Cold Temperature; D004827:Epilepsy / Q000188:drug therapy* / Q000209:etiology; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*; D013997:Time Factors
chemical_list: D007649:Ketamine