title: Role of testosterone and dihydrotestosterone in spontaneous gynecomastia of adolescents.
abstract: To test a possible hormonal mechanism of gynecomastia at puberty, a group of pubertal spontaneous gynecomastia (PSG) and healthy young volunteers (HYV), Tanner's stage II-V, were studied. Peripheral blood samples were obtained for measuring follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), testosterone (T), dihydrotestosterone (DHT), estradiol (E-2) and estrone (E-1). No difference was established in steroids in pituitary hormonal concentration when both groups were compared on a sexual stage-matched control basis, except for T 2 SD in 5/9 subjects of PSG and DHT 2 SD in all of PSG. The T:DHT ratio varied from 5.0 to 15.4 in PSG and from 0.42 to 2.224 in HYV. Whether spontaneous gynecomastia might exist in an enzimatic blockade of 5 alpha-reductase and whether a decrease in the T:DHT ratio might favor the estrogen action for the progression of breast enlargement deserve further analysis.
authors.affiliation: Unidad de Investigación Clinica en Nutrición y, Instituto Mexicano del Seguro Social, México, DF.
authors.forename: S
authors.initials: S
authors.lastname: Villalpando
authors.forename: L
authors.initials: L
authors.lastname: Mondragón
authors.forename: C
authors.initials: C
authors.lastname: Barrón
authors.forename: E
authors.initials: E
authors.lastname: Pérez-Pastén
authors.forename: G
authors.initials: G
authors.lastname: Castañeda
authors.forename: R
authors.initials: R
authors.lastname: Alonso-Uriarte
authors.forename: V
authors.initials: V
authors.lastname: Cortés-Gallegos
mesh_terms: D000293:Adolescent; D013196:Dihydrotestosterone / Q000097:blood*; D006177:Gynecomastia / Q000097:blood*; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D013739:Testosterone / Q000097:blood*
chemical_list: D006728:Hormones; D013196:Dihydrotestosterone; D013739:Testosterone