title: [1,2-Bis(2-hydroxyphenyl)ethylenediamine]dichloroplatinum(II), a new compound for the therapy of ovarian cancer. II. Synthesis and preliminary testing of the enantiomeric complexes.
abstract: The enantiomeric [1,2-bis(2-hydroxyphenyl)-ethylenediamine]dichloroplatinum(II) complexes were synthesized and their configuration assessed. A preliminary test in the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line, which was previously characterized by its sensitivity against several therapeutically used drugs, showed that both enantiomers produce cytocidal effects in a concentration of 2.5 microM. A difference between the enantiomers became evident from the faster onset of cytocidal activity of the S,S-configurated compound.
authors.affiliation: Institut für Pharmazie, Universität Regensburg, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Bernhardt
authors.forename: R
authors.initials: R
authors.lastname: Gust
authors.forename: H
authors.initials: H
authors.lastname: Reile
authors.forename: H D
authors.initials: HD
authors.lastname: vom Orde
authors.forename: R
authors.initials: R
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Keller
authors.forename: T
authors.initials: T
authors.lastname: Spruss
authors.forename: H
authors.initials: H
authors.lastname: Schönenberger
authors.forename: T
authors.initials: T
authors.lastname: Burgemeister
authors.forename: A
authors.initials: A
authors.lastname: Mannschreck
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C073528:(1,2-bis(2-hydroxyphenyl)ethylenediamine)dichloroplatinum (II)