Adsorption and desorption of indomethacin on cellulose-like biopolymers: chitin and chitosan.
The adsorption-desorption effect of cellulose-like biopolymers such as chitin and chitosan, and microcrystalline cellulose on indomethacin was investigated. The adsorptive capacity was ranked in the order: chitosan greater than chitin greater than microcrystalline cellulose. All the adsorption isotherms were found to follow Langmuir and Freundlich equations. However, chitosan-acetate gel powders and chitosan powders with pre-added acetic acid and methanol did not follow these equations, due to gel formations that led to more adsorption of indomethacin on the interlayer space of the gel. The strong adsorption of chitosan might result in difficult desorption of indomethacin.
Lin
S Y
SY
Department of Medical Research, Veterans General Hospital-Taipei, Republic of China.
Perng
R I
RI
D002240:Carbohydrate Sequence; D002626:Chemistry, Pharmaceutical; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D007213:Indomethacin / Q000737:chemistry*; D008969:Molecular Sequence Data
D002686:Chitin; D048271:Chitosan; D007213:Indomethacin