Deafferentation syndrome in the rat: effects of sex, age, and lesion type.
A deafferentation syndrome can be produced in Sprague-Dawley rats following dorsal root sections. The behavior may be objective evidence of dysesthesias, thus serving as an experimental model to study chronic dysesthesias caused by deafferentation in humans. This article examines the effects of sex, age, and lesion type on the expression of the deafferentation syndrome in Sprague-Dawley rats. No significant differences were found in the expression of the deafferentation syndrome with respect to age and weight in male rats within the ranges studied. Sex and lesion type did alter the expression of the syndrome.
Rossitch
E
E
Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina 27710.
Lyerly
M A
MA
Ovelmen-Levitt
J
J
Young
J N
JN
Nashold
B S
BS
D000375:Aging / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight; D005260:Female; D015171:Ganglionectomy; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis; D012727:Sex Characteristics; D013126:Spinal Nerve Roots / Q000601:surgery; D013577:Syndrome