title: [Relations between the levels of lipoprotein (a) and results of coronarography in patients with ischemic heart disease. Preliminary results].
abstract: The authors make a short revision about Lipoprotein(a) [Lp(a)], which has been referred as an independent risk factor for coronary disease. To confirm this results in a portuguese population, we studied serum Apo(a) [method IRMA.Kit Pharmacia.1 U/L Apo(a) = 1 mg/L Lp(a)], Apo A, Apo B, total cholesterol, HDL-cholesterol, triglycerides, calcium, uric acid, glucose, fibrinogen and ESR in 37 patients who were submitted to postmyocardial infarction coronarography (Judkins technic--Seldinger. Classic incidences. Significative lesions: greater than or equal to 75% in coronary vessels or greater than or equal to 50% in common main nk). The purpose was to search for changes on the plasmatic levels according to the results of the coronarography. The only change observed was in the Lp(a) levels, with important variations (p less than 0.05) between the defined groups: patients without significant coronary disease or disease on just one vessel [media (mean) = 30.1 mg/dl. Standard error (SE) = 7.9 mg/dl.n = 11] and another group of patients with coronary disease of two or three vessels [mean = 50.5 mg/dl.SE = 7.0 mg/dl.n = 26]; among the patients with two vessels disease were found significant changes (p less than 0.02) on Lp(a) levels according to the descending anterior coronary being [mean = 79.5 mg/dl.SE = 4.3 mg/dl.n = 8] or not [mean = 38.5 mg/dl.SE = 14.3 mg/dl.n = 7] implicated. These observations make the suggestion of Lp(a) as a risk factor for coronary disease, and a predictor for the gravity of the coronary disease in myocardial infarction.
authors.affiliation: Serviços de Medicina II dos HUC, Coimbra.
authors.forename: J M
authors.initials: JM
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Maldonado
authors.forename: I
authors.initials: I
authors.lastname: Rocha
authors.forename: A
authors.initials: A
authors.lastname: Costa
authors.forename: J
authors.initials: J
authors.lastname: Morais
authors.forename: M E
authors.initials: ME
authors.lastname: Morais
authors.forename: H
authors.initials: H
authors.lastname: Ribeiro
authors.forename: M
authors.initials: M
authors.lastname: Freitas
authors.forename: L A
authors.initials: LA
authors.lastname: Providência
authors.forename: P S
authors.initials: PS
authors.lastname: Silva
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D017270:Lipoprotein(a); D008074:Lipoproteins
vernacular_title: Ralação entre os níveis da Lipoproteína (a) e o resultado da coronariografia em doentes com cardiopatia isquémica. Resultados preliminares.