Review of regional therapy of liver metastases in colorectal cancer.
Hepatic metastases are a major cause of mortality in patients with colorectal carcinoma. The rationale for regional therapy is presented. The randomized studies are reviewed and they demonstrated a significantly higher response rate with hepatic arterial therapy versus systemic therapy. Survival information is difficult to evaluate because some of the studies are small and some had a crossover design, but two studies demonstrate a significant improvement in 2-year survival after hepatic arterial therapy versus systemic therapy. New modalities to increase response rate and decrease toxicity are presented.
Kemeny
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Memorial Sloan Kettering Cancer Center, New York, NY 10021.
D015179:Colorectal Neoplasms; D005467:Floxuridine / Q000008:administration & dosage* / Q000378:metabolism; D006499:Hepatic Artery; D006801:Humans; D007260:Infusion Pumps; D007261:Infusions, Intra-Arterial; D002955:Leucovorin / Q000008:administration & dosage; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary*; D016032:Randomized Controlled Trials as Topic
D005467:Floxuridine; D002955:Leucovorin