title: [Metabolic transformation of schizandrin].
abstract: The metabolic transformation of schizandrin, isolated from the kernel of Schizandra chinensis Bill, was studied in vitro with phenobarbital-induced rat liver microsomal fractio containing the NADPH-generating system. The major metabolites were isolated by preparative HPLC and identified as 7,8-dihydroxy-schizandrin, 7,8-dihydroxy-2-demethyl schizandrin and 7,8-dihydroxy-3-demethyl schizandrin by UV, NMR, MS spectral analysis. The 7,8-dihydroxy-schizandrin was confirmed further by comparison with spectral and chromatographic behavior of the authentic compound. The metabolic biotransformation of schizandrin in vivo was also determined.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Cui
authors.forename: M Z
authors.initials: MZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D034242:Cyclooctanes; D017705:Lignans; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D011083:Polycyclic Compounds / Q000493:pharmacokinetics*; D051381:Rats
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D011083:Polycyclic Compounds; C011105:schizandrin