Selective inhibition of cough and bronchoconstriction in conscious guinea pigs.
In guinea-pigs citric acid-induced cough and bronchoconstriction were inhibited by beta 2-agonist and xanthine drugs. Lidocaine inhibited only cough. Cromoglycate and ipratropium bromide inhibited only bronchoconstriction. We conclude that cough and bronchoconstriction in guinea-pigs are distinct reflexes and that the inhibitory pharmacology of these airway reflexes may agree in many respects, with that observed in asthmatic subjects.
Forsberg
K
K
Astra Draco AB, Lund, Sweden.
Karlsson
J A
JA
Zackrisson
C
C
Persson
C G
CG
D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D016084:Bronchoconstriction / Q000187:drug effects*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002951:Citrates; D019343:Citric Acid; D003371:Cough / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D006168:Guinea Pigs; D009241:Ipratropium / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D013726:Terbutaline / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology
D000996:Antitussive Agents; D001993:Bronchodilator Agents; D002951:Citrates; D014970:Xanthines; D019343:Citric Acid; D008012:Lidocaine; D013806:Theophylline; C034347:enprofylline; D009241:Ipratropium; D013726:Terbutaline