Olfactory bulbectomy as a model for agitated hyposerotonergic depression.
Ablation of olfactory bulbs in rats reduced male sexual behavior, and altered the distribution of wheel-running activity between the light and dark phases of a 12:12 LD photoperiod. These effects were partially reversed by the tricyclic antidepressant amitriptyline. Olfactory bulbectomy also altered serotonin metabolism (5-HIAA/5-HT ratio) in the frontal cortex, nucleus accumbens, hippocampus and corpus striatum. These observations support the hypothesis that olfactory bulbectomy in rodents serves as a model of agitated hyposerotonergic depression.
Lumia
A R
AR
Biopsychology Program, Skidmore College, Saratoga Springs, NY 12866.
Teicher
M H
MH
Salchli
F
F
Ayers
E
E
Possidente
B
B
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm / Q000187:drug effects; D003863:Depression / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009830:Olfactory Bulb / Q000502:physiology*; D051381:Rats; D012701:Serotonin / Q000172:deficiency*; D012726:Sexual Behavior, Animal / Q000187:drug effects
D015306:Biogenic Monoamines; D000639:Amitriptyline; D012701:Serotonin