Blood levels and acute response to bupropion.
Twenty-three patients with major depressive disorder were treated with bupropion in an open-design protocol. Fifteen (65.2%) of the 23 responded with a more than 50% decrease in scores on the Beck Depression Inventory. Patients with trough blood levels of 10-29 ng/ml had a significantly better response than those with trough levels of 30 ng/ml or more. This preliminary result warrants further, double-blind evaluation.
Goodnick
P J
PJ
Department of Psychiatry, University of Miami, FL 33136.
D000328:Adult; D016642:Bupropion / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D016642:Bupropion