title: Bioavailability to rats and toxicity in mice of carbofuran residues bound to faba beans.
abstract: 14C-carbofuran penetrated readily into seeds of Vicia faba and the rate of penetration was found to be dose dependent. The percentage of bound residues was generally low and did not exceed 3% of the applied dose. When the bound residues were fed to rats 46% of the radioactivity was eliminated via CO2 and urine, while tissues contained 25%. Carbofuran phenol and 3-hydroxy carbofuran represented the main metabolites in the urine. These data indicate that bean-bound carbofuran residues are highly bioavailable to rats. Feeding mice with bound carbofuran residues for 90 days led to inhibition of erythrocyte cholinesterase activity after 30 days (35-40%) while the plasma enzyme remained unaffected. Serum transaminases and blood urea nitrogen were significantly elevated, indicating injury to hepatic and renal structures. The results strongly suggest that the bound residues can induce adverse biological effects in mice.
authors.affiliation: Middle Eastern Regional Radioisotope Centre for the Arab Countries, Cairo, Egypt.
authors.forename: I Y
authors.initials: IY
authors.lastname: Mostafa
authors.forename: S M
authors.initials: SM
authors.lastname: Zayed
authors.forename: M
authors.initials: M
authors.lastname: Farghaly
authors.forename: F
authors.initials: F
authors.lastname: Mahdy
mesh_terms: D000818:Animals; D001682:Biological Availability; D002235:Carbofuran / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D002802:Cholinesterases / Q000187:drug effects / Q000378:metabolism; D007887:Fabaceae; D005260:Female; D005506:Food Contamination / Q000032:analysis; D005511:Food Handling; D008297:Male; D051379:Mice; D010573:Pesticide Residues / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D010573:Pesticide Residues; D002802:Cholinesterases; D002235:Carbofuran