title: Diagnostic and prognostic criteria for heat stroke with special reference to plasma enzyme and isoenzyme release patterns.
abstract: 1. The aim of this study was to investigate the potential value of isoenzyme release patterns as parameters of hyperthermic injury in improving the diagnostic protocol for heat stroke. 2. Rats were exposed to combinations of exercise and hyperthermic stress. Following exposure, respective release patterns of isoenzymes were determined. 3. Isoenzyme release patterns following hyperthermic injury portray both the type and extent of tissue damage more clearly than do plasma total enzyme release patterns. 4. The sensitivity of isoenzymes as a diagnostic criterion is extended to include both a temporal component (i.e. an accurate diagnosis will be possible at an earlier stage subsequent to hyperthermic exposure) and at the same time to be indicative of the exposure.
authors.affiliation: Chamber of Mines Research Organization, Johannesburg, South Africa.
authors.forename: A
authors.initials: A
authors.lastname: van der Linde
authors.forename: A J
authors.initials: AJ
authors.lastname: Kielblock
authors.forename: D A
authors.initials: DA
authors.lastname: Rex
authors.forename: S E
authors.initials: SE
authors.lastname: Terblanche
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001831:Body Temperature; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D004798:Enzymes / Q000097:blood*; D006359:Heat Exhaustion / Q000175:diagnosis* / Q000201:enzymology; D007527:Isoenzymes / Q000097:blood*; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D005082:Physical Exertion; D011379:Prognosis; D051381:Rats; D013312:Stress, Physiological / Q000097:blood
chemical_list: D004798:Enzymes; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase