Pharmacokinetics of lorazepam in critically ill neonates with seizures.
Pharmacokinetic data were evaluated in 10 term neonates with seizures after intravenous administration of lorazepam, 0.05 mg/kg or 0.1 mg/kg. All seizure activity ceased, with no adverse effects. Pharmacokinetic data revealed a decreased volume of distribution and clearance, and a prolonged half-life in comparison with data from older children and adults. These findings are consistent with physiologic differences in the neonate.
McDermott
C A
CA
Department of Pediatrics, Lutheran General Children's Medical Center, Park Ridge, Illinois.
Kowalczyk
A L
AL
Schnitzler
E R
ER
Mangurten
H H
HH
Rodvold
K A
KA
Metrick
S
S
D016638:Critical Illness; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D007275:Injections, Intravenous; D008140:Lorazepam / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy* / Q000378:metabolism
D008140:Lorazepam