title: Infection after injury: association with blood transfusion.
abstract: This study was undertaken to evaluate the association between red blood cell transfusions and infections in an easily stratified, homogenous group of injured adults. All received their initial transfusions upon arrival to the emergency department. Over 5 years, 390 uncross-matched trauma patients received type "O" red blood cells (RBCs) during initial resuscitation. One hundred fifty-four (39%) died within 7 days because of injuries sustained: 236 (61%) survived at least 7 days. Of these 236, clear differences could be seen between those receiving 6 or fewer or 7 or more units of RBCs. When adjusted for age, sex, and severity of injury (Champion Trauma Score, Injury Severity Score, TRISS), the risk of infection was higher in those receiving 7 or more units of RBCs. Similarly, risk of infection was related to units of RBCs transfused in a dose-related fashion. Blood transfusions should be avoided, if possible. Arbitrary "trigger points" for transfusions should be abandoned.
authors.affiliation: Department of Surgery, University of South Florida, Tampa 33606.
authors.forename: A S
authors.initials: AS
authors.lastname: Rosemurgy
authors.forename: M B
authors.initials: MB
authors.lastname: Hart
authors.forename: C G
authors.initials: CG
authors.lastname: Murphy
authors.forename: M H
authors.initials: MH
authors.lastname: Albrink
authors.forename: A
authors.initials: A
authors.lastname: Piazza
authors.forename: G F
authors.initials: GF
authors.lastname: Leparc
authors.forename: R E
authors.initials: RE
authors.lastname: Harris
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D001424:Bacterial Infections / Q000209:etiology*; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D007422:Intestines / Q000293:injuries; D008297:Male; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012307:Risk Factors; D015996:Survival Rate; D065227:Transfusion Reaction; D015599:Trauma Severity Indices; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D000017:ABO Blood-Group System