Cells can use their transferrin receptors for locomotion.
Cells of the B lymphoblastoid cell line JY attach to substrata made of antibodies to the transferrin receptor. Many of these attached cells migrate considerable distances. JY cells also attach to an anti-integrin substratum (anti LFA-1), but on this surface they do not migrate. These results suggest that a circulating receptor--the transferrin receptor--can be used for locomotory purposes, whereas LFA-1, which is not endocytosed in these cells, cannot be used for locomotion. This indicates that the endocytotic cycle can drive cell locomotion.
Bretscher
M S
MS
MRC, Laboratory of Molecular Biology, Cambridge, UK.
D001402:B-Lymphocytes; D002460:Cell Line; D002465:Cell Movement / Q000502:physiology*; D004705:Endocytosis; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology / Q000502:physiology*; D008938:Mitosis; D011990:Receptors, Transferrin / Q000276:immunology / Q000502:physiology*
D007140:Immunoglobulin Fab Fragments; D016169:Lymphocyte Function-Associated Antigen-1; D011990:Receptors, Transferrin