Antiplaque efficacy of a triclosan/copolymer prebrush rinse: a plaque prevention clinical study.
A 5-day, double-blind parallel clinical study was conducted to determine the antiplaque efficacy of a pre-brush rinse containing 0.03% triclosan and 0.125% of a copolymer of polyvinyl methyl ether maleic acid as compared to a matching matching placebo pre-brush rinse. A total of 114 subjects were stratified into two balanced groups according to baseline Quigley-Hein Plaque Index scores. Each group was randomly assigned to use either the triclosan/copolymer pre-brush rinse or the placebo pre-brush rinse. All subjects received a thorough oral prophylaxis at the start of the study. They rinsed their mouths twice daily (mornings and evenings) for 1 minute with 15 cc of their assigned pre-brush rinse. Immediately after rinsing, subjects brushed their teeth for 30 seconds with a commercially-available dentifrice containing 0.76% sodium monofluorophosphate and a soft-bristled toothbrush. The morning rinsing/brushing procedure was done under supervision at the clinical facility. The evening rinsing/brushing procedure was done at home. After 5 days' use of their assigned pre-brush rinse, subjects were evaluated for plaque formation using the modified Quigley-Hein Plaque Index scoring system. As compared to the matching placebo pre-brush rinse, the results showed: 1) The triclosan/copolymer pre-brush rinse provided a 28.15% reduction in plaque formation on all surfaces of the teeth. This reduction was statistically significant (P less than 0.001); 2) The triclosan/copolymer pre-brush rinse provided a 50% reduction in plaque formation on the "more difficult to brush" surfaces of the teeth.(ABSTRACT TRUNCATED AT 250 WORDS)
Deasy
M J
MJ
University of Medicine and Dentistry, New Jersey Dental School.
Gattista
G
G
Rustogi
K N
KN
Volpe
A R
AR
D000328:Adult; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use*; D009067:Mouthwashes / Q000627:therapeutic use*; D011095:Polyethylenes / Q000627:therapeutic use*; D014260:Triclosan / Q000627:therapeutic use*
D008298:Maleates; D009067:Mouthwashes; D011095:Polyethylenes; D014260:Triclosan; C043105:poly(methyl vinyl ether-co-maleic anhydride)