title: Quality of life improvements in CAPD patients treated with subcutaneously administered erythropoietin for anemia.
abstract: Twenty-two continuous ambulatory peritoneal dialysis (CAPD) patients, mean age 48 years, at 3 U.K. renal units were assessed with the Nottingham Health Profile (NHP) before and after treatment with recombinant human erythropoietin (r-HuEPO). Mean (SD) hemoglobin (Hb) at baseline was 7.5 (1.0) gm/dL and 10.8 (1.5) gm/dL at retest. There were significant improvements in energy (p less than 0.0001), social life (p less than 0.005), relationships at home (p less than 0.05) and leisure pursuits (p less than 0.05). Twelve patients, mean age 51 years, who had already completed more than 9 months on r-HuEPO treatment were reassessed to determine the changes sustained. Mean (SD) Hb at second retest was 12.8 (1.3) gm/dL. Improvement in energy continued to be significant, and emotional wellbeing showed further improvement. Problems with household tasks, which had not shown significant improvement at Test B, were now considerably reduced (p = 0.016). The study showed far-reaching benefits similar to those reported in hemodialysis patients, in a population with a higher mean age and higher potential coexisting illness or disability than most reported hemodialysis studies.
authors.affiliation: Churchill Hospital, Oxford, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Auer
authors.forename: G
authors.initials: G
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Stevens
authors.forename: P
authors.initials: P
authors.lastname: Griffiths
authors.forename: D
authors.initials: D
authors.lastname: Howarth
authors.forename: E
authors.initials: E
authors.lastname: Anastassiades
authors.forename: R
authors.initials: R
authors.lastname: Gokal
authors.forename: D
authors.initials: D
authors.lastname: Oliver
mesh_terms: D000203:Activities of Daily Living; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000523:psychology*; D011788:Quality of Life; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin