["Primary" pulmonary arterial hypertension associated with HIV infection. Two cases].
We report two cases of pulmonary arterial hypertension (PAHT) in HIV infected patients who never were, or had ceased to be, drug addicts. A study of these cases and a review of the literature show that this association is not fortuitous and persists after the classical causes of PAHT (pulmonary embolism, toxic factors, cirrhosis) have been excluded. The clinical features and the results of complementary cardiovascular examinations are identical with those of the so-called "primary" PAHT. The prognosis is severe: 50 percent of the patients died of the consequences of PAHT 1 year after the first clinical signs. Histology displays signs of plexogenic pulmonary arteriopathy, as in primary PAHT. In HIV patients pulmonary arterial hypertension occurs independently of the degree of immunodeficiency. Its relation with other HIV-related vasculites and their physiopathology are discussed.
Piette
A M
AM
Service de Médecine interne, Centre médico-chirurgical Foch, Suresnes.
Legoux
B
B
Gepner
P
P
Chapman
A
A
D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D008297:Male; D014665:Vasodilator Agents / Q000627:therapeutic use
D014665:Vasodilator Agents
Hypertension artérielle pulmonaire "primitive" associée à l'infection par le VIH. Deux observations.