[Experimental studies on antitumor effects of endogenously induced LAK (CTL) therapy for metastatic liver tumor].
Antitumor effects of endogenously induced LAK (CTL) therapy by trans-hepatic arterial administration with OK-432 and rIL-2 for metastatic liver tumor were examined.


RESULTS
The number of metastatic nodules (NMN) showed a significant correlation with the number of inoculated tumor cells. NMN of the treated group was significantly reduced over that of the saline group in cases of 2.5 x 10(6) VX2 cells inoculation, while the survival day showed no prolongation even in the treated group. On the other hand, when 1 x 10(5) tumor cells were inoculated the survival day was slightly more prolonged in the treated group than in the saline group. The PHA-induced blastogenesis of peripheral blood was significantly increased at 10 days after the therapy in case of non-tumor bearer, while in cases of tumor bearer it was decreased at 7 days after the therapy.
Kaneda
N
N
2nd Dept. of Surgery, Gifu University School of Medicine.
Saji
S
S
Kashizuka
T
T
Kawai
M
M
Sugiyama
Y
Y
Miya
K
K
D000818:Animals; D005260:Female; D007376:Interleukin-2 / Q000627:therapeutic use*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000556:secondary / Q000628:therapy*; D008213:Lymphocyte Activation; D010844:Picibanil / Q000627:therapeutic use*; D011817:Rabbits
D007376:Interleukin-2; D010844:Picibanil