Abnormal expression of actin in lymphocytes of Alzheimer's disease and Down's syndrome patients.
Alzheimer's disease (AD) is a degenerative disorder of the central nervous system accompanied by several immunological disturbances and a number of common features exist between AD and Down's syndrome (DS). High resolution two-dimensional electrophoresis of lymphocyte proteins demonstrates an actin abnormality in AD and DS: a double actin spot instead of the single spot observed in controls. This dual form was studied by pulse-chase experiments and seems to be related to extracellular factors which influence the post-translational modification of actin. These results agree with the immunological disturbances observed in AD and DS, and with the well established hypothesis that AD is a systemic as well as cerebral disease.
Jabbour
W
W
Laboratoire de Biologie Cellulaire, INSERM U 298, Centre Hospitalier Universitaire, Angers, France.
Pouplard-Barthelaix
A
A
Houlgatte
R
R
Emile
J
J
D000199:Actins / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D003470:Culture Media; D004314:Down Syndrome / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008715:Methionine; D008875:Middle Aged; D010449:Peptide Mapping
D000199:Actins; D003470:Culture Media; D008715:Methionine