title: Fundamental and clinical aspects of anti neutrophil cytoplasmic antibodies (ANCA).
abstract: Anti-neutrophil cytoplasmic antibodies (ANCA) are associated with different forms of both primary and secondary vasculitis and glomerulonephritis. These antibodies are directed against different enzymes located in granulocyte granules. In this review ANCA-related antigens and solid phase assays for ANCA detection will be discussed. Furthermore, we will address the clinical relevance of ANCA and will deliberate on their possible pathogenic implications.
authors.affiliation: University Hospital, Department of Nephrology, Leiden, The Netherlands.
authors.forename: E C
authors.initials: EC
authors.lastname: Hagen
authors.forename: B E
authors.initials: BE
authors.lastname: Ballieux
authors.forename: M R
authors.initials: MR
authors.lastname: Daha
authors.forename: L A
authors.initials: LA
authors.lastname: van Es
authors.forename: F J
authors.initials: FJ
authors.lastname: Van der Woude
mesh_terms: D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D003593:Cytoplasm / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology; D014890:Granulomatosis with Polyangiitis / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007158:Immunologic Techniques; D009504:Neutrophils / Q000276:immunology*; D013577:Syndrome; D014657:Vasculitis / Q000276:immunology
chemical_list: D001324:Autoantigens; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M