Aminophylline hypersensitivity apparently due to ethylenediamine.
Asthmatic patients receive multiple drugs as part of their treatment program. When a subsequent allergic reaction occurs, the ethylenediamine component of aminophylline is usually not suspected as the etiologic agent. We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation. Patch testing for ethylenediamine was positive.
Terzian
C G
CG
Section of General Internal Medicine, College of Medicine, University of Illinois, Chicago.
Simon
P A
PA
D000208:Acute Disease; D000628:Aminophylline / Q000008:administration & dosage / Q000009:adverse effects* / Q000737:chemistry; D001249:Asthma / Q000188:drug therapy*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004636:Emergency Service, Hospital; D005029:Ethylenediamines / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007275:Injections, Intravenous; D008875:Middle Aged; D010328:Patch Tests
D005029:Ethylenediamines; D000628:Aminophylline; C031234:ethylenediamine