The protective effect of puerarin against myocardial reperfusion injury. Study on cardiac function.
In order to find out if puerarin could protect the hearts from myocardial reperfusion injury after cardiac arrest, twelve dogs divided into two equal groups were placed on moderately hypothermic cardiopulmonary bypass and their hearts were subjected to 140 min of cold cardioplegic arrest and 60 min of reperfusion. In the control group, the hearts were perfused with a crystalloid cardioplegic solution (CPS) through the aortic root every 20 min during arrest. In the treated group, the hearts received CPS containing puerarin (2 mg/kg). Cardiac hemodynamic variables were monitored throughout the experiments. Left ventricular function curves were formed before ischemia and after 60 min of reperfusion. The results showed that the recovery of left ventricular function in the treated group was significantly better than that in the controls (81 +/- 11% versus 39 +/- 7%, P less than 0.01). Compared with preischemic values, the increase of coronary blood flow (CBF) at cardiac arrest in the puerarin-treated group was higher than that in the control group (214 +/- 11 versus 177 +/- 4 ml/min, P less than 0.01). The data indicate that puerarin has protective effects on the cardiac function after prolonged arrest and reperfusion.
Fan
L L
LL
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Sun
L H
LH
Li
J
J
Yue
X H
XH
Yu
H X
HX
Wang
S Y
SY
D000818:Animals; D002314:Cardioplegic Solutions; D002315:Cardiopulmonary Bypass; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016277:Ventricular Function, Left / Q000502:physiology*
D002314:Cardioplegic Solutions; D007529:Isoflavones; D014665:Vasodilator Agents; C033607:puerarin