title: Recurrent renal vein thrombosis and renal failure associated with antithrombin-III deficiency.
abstract: This paper describes a healthy 13-year-old girl presenting with acute flank pain and anuria due to renal vein thrombosis. A similar spontaneous and unexplained thrombosis resulted in the loss of the contralateral kidney 1 year earlier. Urgent surgical thrombectomy and anticoagulation resulted in moderate recovery of renal function. Predisposition to venous thrombosis in this child was secondary to a marked familial deficiency of circulating antithrombin-III. An early diagnosis of this condition is essential for the formulation of preventive measures and may lead to specific therapeutic intervention at the onset of acute thrombotic complications.
authors.affiliation: Nephrology Division, Children's Hospital of Pittsburgh, PA 15213.
authors.forename: D
authors.initials: D
authors.lastname: Ellis
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D020152:Antithrombin III Deficiency; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007677:Kidney Function Tests; D012008:Recurrence; D012082:Renal Veins / Q000000981:diagnostic imaging; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D014463:Ultrasonography
chemical_list: D006493:Heparin