Prevalence of antibodies to recombinant virion infectivity factor in the sera of prospectively studied patients with HIV-1 infection.
Two hundred twenty-four sera were collected from 34 HIV-1 infected patients during an observation period of up to 4.5 years (109 patient years of observation). The sera were tested for the presence of antibodies against the HIV-1 virion infectivity factor (vif) protein. Thirty sera from 6 HIV-1 seronegative individuals served as negative controls. The sera were immunoblotted against a recombinant, prokaryotically expressed vif protein. The prevalence of anti-vif antibodies increased significantly with progression of the disease from 18% to 81% (P less than 0.0001) which suggests a possible role of vif in HIV-1 replication and pathogenicity.
Schwander
S
S
Department of Clinical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Braun
R W
RW
Kühn
J E
JE
Hufert
F T
FT
Kern
P
P
Dietrich
M
M
Wieland
U
U
D015415:Biomarkers; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013997:Time Factors
D015415:Biomarkers; D015483:HIV Antibodies