A case of nephrotic syndrome and renal dysfunction in a pregnant woman with diabetes mellitus.
A 29-year-old diabetic woman who developed severe anaemia, nephrotic syndrome, and hypertension before the 28th week of gestation, had residual evidence of toxaemia and renal dysfunction more than 1 month following delivery. The histopathological findings of renal biopsy specimens were considered most consistent with toxaemia of pregnancy complicated by diabetic glomerulosclerosis. We consider that rapid acceleration of renal dysfunction may have been induced by: (1) poor control of diabetes before pregnancy; (2) glomerular hyperfiltration of the remnant nephrons throughout pregnancy; (3) hypercoagulopathy associated with pregnancy; (4) appearance of hypertension following these three conditions.
Hironaka
K
K
Third Department of Medicine, Okayama University Medical School, Japan.
Makino
H
H
Kumagai
I
I
Haramoto
T
T
Yamasaki
Y
Y
Shikata
K
K
Takahashi
M
M
Nishii
M
M
Ota
Z
Z
D000328:Adult; D001485:Basement Membrane / Q000648:ultrastructure; D001706:Biopsy; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002196:Capillaries / Q000648:ultrastructure; D003928:Diabetic Nephropathies / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005260:Female; D005920:Glomerular Mesangium / Q000648:ultrastructure; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000098:blood supply / Q000473:pathology; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D009543:Nifedipine / Q000031:analogs & derivatives / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D011644:Puerperal Disorders / Q000503:physiopathology
D002121:Calcium Channel Blockers; D007328:Insulin; C035100:nilvadipine; D009543:Nifedipine