[Effect of the dry distillation tar of delipidated soybean (Glyteer) on a psoriasic model in the mouse (4)].
Effect of Glyteer (GL) on edema and epidermal hyperplasia in mouse ear by 12-o-tetradecanoylphorbol-13-acetate (TPA) were investigated by its topical application; and the effects were compared with those of betamethasone 17-valerate (BV), indomethacin (IM) and cyclosporin (CS). GL significantly inhibited the edema in mouse ear at 6 hr after TPA treatment. The inhibitory activity of GL on the edema had the same potency as those of BV, IM and CS. Furthermore, GL inhibited the epidermal weight and its protein amount on the hyperplastic response in mouse ear at 3 days after TPA treatment, and the inhibitory activity of GL was also confirmed by the pathologic findings. The mode of the inhibitory action of GL was the same as those of BV and CS, but not that of IM. From those results, it is suggested that GL possesses a potent therapeutic effect for psoriasis.
Ito
K
K
Research Laboratory, Fujinaga Pharmaceutical Co., Ltd., Tokyo, Japan.
Namikawa
S
S
Takeuchi
K
K
D000818:Animals; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006965:Hyperplasia / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D011506:Proteins / Q000378:metabolism; D011565:Psoriasis / Q000139:chemically induced / Q000188:drug therapy*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013025:Glycine max; D013638:Tars / Q000627:therapeutic use*; D013755:Tetradecanoylphorbol Acetate
D003879:Dermatologic Agents; D011506:Proteins; D013638:Tars; C007876:glyteen; D013755:Tetradecanoylphorbol Acetate