Cytogenetic study of acute lymphoblastic leukemia and its correlation with immunophenotype and genotype.
Among 72 Chinese patients with acute lymphoblastic leukemia (ALL), 50 had clonal chromosomal abnormalities. Structural abnormalities were detected in 42 patients: these included t(9;22) in 9, t(1;19) in 6, t(4;11) in 5, del(11)(q23) in 4, and del(6q) in 4. Adults had a higher incidence of t(9;22) and t(1;19) but a lower incidence of t(4;11) and hyperdiploid greater than 50 karyotype than children. A significant difference was also noted in white blood cell (WBC) count among various karyotypic groups. Patients with chromosomal abnormalities t(9;22), t(1;19), t(4;11) and del(11) (q23) had a shorter complete remission duration as compared with patients free of these abnormalities. Immunophenotyping was performed on 69 patients. All patients with t(9;22), t(1;19), and t(4;11) had B-lineage ALL restricted to certain stages of maturation: groups III and IV, groups IV and V, and group II, respectively (according to the classification of Foon and Tood). Among patients with t(9;22), t(4;11), and del(11)(q23), which have been considered to be associated with acute mixed-lineage leukemia, one each, respectively, showed myeloid antigen expression on the leukemic blasts (My+ ALL). No cross-lineage rearrangements of immunoglobulin (Ig) or T-cell receptor (TCR) genes were detected in these karyotypic subgroups of patients who underwent gene analysis.
Tien
H F
HF
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Wang
C H
CH
Lee
F Y
FY
Liu
M C
MC
Chuang
S M
SM
Chen
Y C
YC
Shen
M C
MC
Lin
D T
DT
Lin
K H
KH
Chuu
W M
WM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D015139:Blotting, Southern; D001854:Bone Marrow Cells; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002877:Chromosomes, Human; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D002892:Chromosomes, Human, Pair 22; D002894:Chromosomes, Human, Pair 4; D002899:Chromosomes, Human, Pair 9; D005260:Female; D015321:Gene Rearrangement; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007223:Infant; D016256:Lewis X Antigen / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011123:Polyploidy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014178:Translocation, Genetic; D014312:Trisaccharides / Q000235:genetics
D000951:Antigens, Neoplasm; D007143:Immunoglobulin Heavy Chains; D016256:Lewis X Antigen; D011948:Receptors, Antigen, T-Cell; D014312:Trisaccharides