Serum amyloid A protein concentration in bone marrow transplantation for beta thalassaemia.
OBJECTIVE
To investigate whether serum amyloid A protein (SAA) and C-reactive protein (CRP) concentrations could be used in the management of beta thalassaemic patients undergoing bone marrow transplantation (BMT).


METHODS
Serum SAA and CRP concentrations were determined in paired samples from 66 patients with beta thalassaemia before and after BMT. Serum SAA concentrations were determined by an enzyme linked immunoassay (EIA); serum CRP concentrations were determined by a nephelometric assay.


RESULTS
Serum SAA concentrations before transplantation were significantly higher in the group that subsequently rejected the transplant than the group without complications. SAA concentrations increased after BMT in acute graft versus host disease (GvHD) and rejection. No significant increase in SAA or CRP was found in chronic GvHD. Increases in serum in SAA and CRP concentrations were not related to concomitant infection episodes.


CONCLUSIONS
The different acute phase response in acute GvHD and rejection compared with chronic GvHD suggests that different immunopathogenic mechanisms are responsible.
Uguccioni
M
M
Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla-Putti, Bologna, Italy.
Meliconi
R
R
Lalli
E
E
Nesci
S
S
Delfini
C
C
Lucarelli
G
G
Gasbarrini
G
G
Facchini
A
A
D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000502:physiology*; D002097:C-Reactive Protein / Q000032:analysis*; D002908:Chronic Disease; D006084:Graft Rejection / Q000502:physiology; D006086:Graft vs Host Disease / Q000097:blood*; D006801:Humans; D011184:Postoperative Period; D000685:Serum Amyloid A Protein / Q000032:analysis*; D013789:Thalassemia / Q000097:blood* / Q000601:surgery
D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein