A rank-based mixed model approach to multisite clinical trials.
New rank-based methods for analyzing data from multisite clinical trials are presented in the context of "mixed" linear models. In contrast to current rank methods, the new procedures test for a drug main effect in the presence of a random drug by site interaction (or drug by investigator interaction when there is only one investigator per site). Analogous procedures are also provided for the "fixed-effects" situation, and comparisons are made with current methods. The rationale for an analysis that assumes random investigator effects is described.
Boos
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DD
Department of Statistics, North Carolina State University, Raleigh 27695-8203.
Brownie
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C
D000704:Analysis of Variance; D001699:Biometry; D006801:Humans; D015233:Models, Statistical; D015337:Multicenter Studies as Topic / Q000706:statistics & numerical data*