Adverse effect of verapamil in myasthenia gravis.
Verapamil, a class IV anti-arrhythmic drug that blocks voltage-dependent calcium channels in cardiac and smooth muscle, also has effects on presynaptic and postsynaptic voltage-dependent calcium channels at the neuromuscular junction. In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.
Swash
M
M
Department of Neurology, Royal London Hospital, United Kingdom.
Ingram
D A
DA
D000075202:Contraindications; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications; D004576:Electromyography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000139:chemically induced* / Q000150:complications; D009469:Neuromuscular Junction / Q000187:drug effects; D011183:Postoperative Complications / Q000188:drug therapy; D013610:Tachycardia / Q000188:drug therapy*; D014700:Verapamil / Q000009:adverse effects* / Q000627:therapeutic use
D014700:Verapamil