title: Development of a shielded 241Am applicator for continuous low dose rate irradiation of rat rectum.
abstract: This paper describes the development of sources, applicators, and techniques that can be used to irradiate rat rectums with continuous irradiation at dose rates of interest in brachytherapy, either with the full circumference of the rectum irradiated, or with half of the circumference shielded from the radiation. The system uses encapsulated 241Am sources, to irradiate rat rectum with 60 keV photons continuously at a dose rate of up to 50 cGy/hr. Details of the design and fabrication of the 241Am sources, the rectal applicator, the dosimetry of the system, and the protocols for preparing and irradiating the rats, and for detecting early rectal injury using histological examination of irradiated rectum are presented. Highly effective shielding (attenuation factors as low as 0.04) of half of the circumference of the rat rectum was achievable. Unidirectional 241Am irradiators for intracavitary brachytherapy offer a unique tool for examining the effects of shielding a portion of the circumference of the rat rectum, on the radiation tolerance of the rectum.
authors.affiliation: Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: R
authors.initials: R
authors.lastname: Nath
authors.forename: S
authors.initials: S
authors.lastname: Rockwell
authors.forename: C R
authors.initials: CR
authors.lastname: King
authors.forename: P
authors.initials: P
authors.lastname: Bongiorni
authors.forename: M
authors.initials: M
authors.lastname: Kelley
authors.forename: D
authors.initials: D
authors.lastname: Carter
mesh_terms: D000576:Americium / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001918:Brachytherapy / Q000295:instrumentation*; D004867:Equipment Design; D008297:Male; D011835:Radiation Protection / Q000295:instrumentation*; D011836:Radiation Tolerance; D051381:Rats; D012007:Rectum / Q000502:physiology / Q000528:radiation effects*
chemical_list: D000576:Americium