[Analysis of lymphocyte surface markers in childhood acute lymphoblastic leukemia during maintenance chemotherapy].
In this study we investigated T-cell subsets, HLA-DR and IL2 receptor (IL2R, CD25) expression on T-cells in peripheral blood lymphocytes from the patients with childhood acute leukemia undergoing maintenance chemotherapy with 6-MP and MTX, and compared them with those in the healthy controls. There were decrease of relative number of CD4 positive (CD4+) cells and the increase of relative number of CD8 positive (CD8+) cells in comparison with those in controls; thus the ratio of CD4+ cells to CD 8+ cells decreased. HLA-DR and IL2R expression on T-cells increased in the patients. Increased HLA-DR expression was detected on both CD4+ cells and CD8+ cells, but the increased IL2R expression was related only to CD4+ cells. IL2R expression in the patients with side effects was higher than in controls. Methotrexate (MTX)-induced increase of HLA-DR and IL2R expression was observed in 2 of every 3 patients undergoing intensive chemotherapy.
Sugita
K
K
Second Dept. of Pediatrics, Dokkyo University, School of Medicine, Tochigi, Japan.
Kurosawa
H
H
Sakakibara
H
H
Eguchi
M
M
Furukawa
T
T
D000954:Antigens, Surface / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016516:CD4-CD8 Ratio; D002648:Child; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D015122:Mercaptopurine / Q000008:administration & dosage; D008727:Methotrexate / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012074:Remission Induction; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000954:Antigens, Surface; D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2; D015122:Mercaptopurine; D008727:Methotrexate