[Fluorescein angiographic observation of cellular changes in the retinal pigment epithelium after laser photocoagulation].
Lesions in the retinal pigment epithelium (RPE) of 16 pigmented rabbits were produced by dye laser photocoagulation using with three different wavelengths: 514, 577 and 630 nm. The power setting and exposure time was the same throughout. The size of the coagulation spot was set either at 500 or 1,000 microns. The retinal lesions were examined by high resolution fluorescein angiography on day 2, 7 and 30 after photocoagulation. Scanning electron microscopic examination of RPE was also performed in selected cases. On fluorescein angiography, the damaged RPE cells appeared as negative fluorescent spots with intense fluorescent margins, throughout the period of observation. The size of the lesion also remained constant. There were no difference in the damage or recovery of RPE cells in relation to the 3 different laser wavelengths. In some area of lesion, the fluorescein angiographic findings closely matched those observed by scanning electron microscopy.
Hayashi
N
N
Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Japan.
Yo
Y
Y
Iida
T
T
Abe
T
T
Takahashi
N
N
Yoneya
S
S
D000818:Animals; D005451:Fluorescein Angiography; D007834:Lasers / Q000009:adverse effects; D008028:Light Coagulation / Q000009:adverse effects*; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000528:radiation effects*; D011817:Rabbits