Longitudinal study of bone loss after thyroidectomy and suppressive thyroxine therapy in premenopausal women.
The effects of suppressive doses of L-thyroxine on the appendicular and axial bone mineral content were followed for 12-36 months after total or subtotal thyroidectomy in 15 premenopausal women. Compared to age-matched controls, these patients had a more marked bone loss of the spinal bone mineral content (2.6 +/- 1.9% vs 0.2 +/- 1.2% per year). The changes in radial cortical bone density were not significantly different from the control group. We conclude that when a suppressive therapy with L-thyroxine is necessary the rate of bone loss should be monitored at regular intervals.
Pioli
G
G
Istituto di Clinica Medica Generale, Università di Parma, Italy.
Pedrazzoni
M
M
Palummeri
E
E
Sianesi
M
M
Del Frate
R
R
Vescovi
P P
PP
Prisco
M
M
Ulietti
V
V
Costi
D
D
Passeri
M
M
D000328:Adult; D015519:Bone Density; D001862:Bone Resorption; D002116:Calcitonin / Q000097:blood; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008593:Menopause; D008875:Middle Aged; D011184:Postoperative Period; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use*
D002116:Calcitonin; D013974:Thyroxine