title: Autoantibodies to the chromosomal protein HMG-17 in juvenile rheumatoid arthritis.
abstract: OBJECTIVE
  To determine the antibody profiles in sera from patients with juvenile rheumatoid arthritis (JRA).
  
  
  METHODS
  Immunoblotting using nuclear extracts and recombinant high-mobility group (HMG) nonhistone chromosomal proteins.
  
  
  RESULTS
  Antibodies directed against HMG-17 were found in 47% of antinuclear antibody (ANA)-positive patients with pauciarticular-onset JRA and in 16% of ANA-positive patients with polyarticular-onset JRA. HMG-17 values of 6% and 8%, respectively, were detected in ANA-negative patients with JRA and in those with nonrheumatic diseases.
  
  
  CONCLUSIONS
  There is evidence for a high prevalence of anti-HMG-17 antibodies in sera of patients with pauciarticular-onset JRA.
authors.affiliation: Institute of Molecular Genetics, University of Heidelberg, Federal Republic of Germany.
authors.forename: G
authors.initials: G
authors.lastname: Neuer
authors.forename: M
authors.initials: M
authors.lastname: Bustin
authors.forename: H
authors.initials: H
authors.lastname: Michels
authors.forename: H
authors.initials: H
authors.lastname: Truckenbrodt
authors.forename: F A
authors.initials: FA
authors.lastname: Bautz
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001171:Arthritis, Juvenile / Q000276:immunology* / Q000503:physiopathology; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006609:High Mobility Group Proteins / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D008297:Male
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006609:High Mobility Group Proteins