title: A case of CREST syndrome with rapidly progressive liver damage.
abstract: A patient with CREST syndrome (calcinosis cutis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) who had severe jaundice (total bilirubin 29.1 mg/dl) and rapidly progressive liver damage is reported. The liver damage findings matched the criteria of autoimmune chronic active hepatitis (CAH). There have been no prior reports of a case of CREST syndrome with autoimmune CAH in Japan. Anticentromere antibody (ACA) was detected in the serum; ACA seemed to be related to the pathogenesis of these two diseases.
authors.affiliation: Department of Medicine, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yabe
authors.forename: K
authors.initials: K
authors.lastname: Noma
authors.forename: N
authors.initials: N
authors.lastname: Tada
authors.forename: S
authors.initials: S
authors.lastname: Mochizuki
authors.forename: M
authors.initials: M
authors.lastname: Nagano
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D002114:Calcinosis / Q000150:complications*; D002503:Centromere / Q000276:immunology; D015154:Esophageal Motility Disorders / Q000150:complications; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D011928:Raynaud Disease / Q000150:complications*; D013577:Syndrome; D013684:Telangiectasis / Q000150:complications
chemical_list: D001323:Autoantibodies