[The effect of exposure to 60Co accelerated electrons and gamma quanta on the activity of oxidative and hydrolytic enzymes in the rat brain].
In experiments with 112 male Wistar rats it was shown that accelerated electrons (85 Gy) caused a significant increase in activities of succinate dehydrogenase (SDG) by 15.8% and lactate dehydrogenase (LDG) by 17.0%, and a decrease in activities of alkaline phosphatase (AP) and monoamine oxidase (MAO) by 10.6 and 7.8% respectively within the sensorimotor region of the cerebral cortex immediately after irradiation. Activity of SDG and MAO decreased (by 16.4% and 7.8% respectively) in the caudate nucleus over the same period of time. An increase in the accelerated electron dose from 85 to 500 Gy did not change the direction and the rate of the radiation response of the enzymes. Exposure of rats to 60Co gamma quanta (75 Gy) increased SDG and LDG activity (by 21.4 and 17.3% respectively) within the sensorimotor cortex as late as 10 min after irradiation. A repeated significant increase in SDG and LDG activity was observed 2 hr after irradiation.
Lyshov
V F
VF
Vasin
M V
MV
Chernov
Iu N
IuN
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000528:radiation effects*; D001923:Brain Chemistry / Q000528:radiation effects; D002421:Caudate Nucleus / Q000201:enzymology / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004583:Electrons; D005720:Gamma Rays; D006651:Histocytochemistry; D006867:Hydrolases / Q000528:radiation effects*; D008297:Male; D009044:Motor Cortex / Q000201:enzymology / Q000528:radiation effects; D010088:Oxidoreductases / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003037:Cobalt Radioisotopes; D010088:Oxidoreductases; D006867:Hydrolases
Vliianie vozdeĭstviia uskorennykh élektronov i gamma-kvantov 60Co na aktivnost' okislitel'nykh i gidroliticheskikh fermentov golovnogo mozga krys.