Differential inhibition of a cell surface protease on normal and tumour cells.
This report is concerned with a cell surface protease which may be important for cell migration. We investigated the molecular recognition of this protease on pancreatic carcinoma cells by proteins (a) extractable from the cells of normal pancreas, and (b) present in normal serum. We then compared these data with results obtained from studies on lung carcinoma cells.
Steven
F S
FS
Department of Biochemistry & Molecular Biology, School of Biological Sciences, University of Manchester, U.K.
Benbow
E W
EW
D002265:Carboxylic Ester Hydrolases / Q000032:analysis / Q000037:antagonists & inhibitors*; D010450:Endopeptidases; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology*; D010179:Pancreas / Q000201:enzymology*; D010190:Pancreatic Neoplasms / Q000201:enzymology*
D002265:Carboxylic Ester Hydrolases; C037288:guanidinobenzoate esterase; D010450:Endopeptidases