title: Nodular sclerosing Hodgkin's disease showing positive reaction for anti-IL 6/BSF2 antibody.
abstract: A 53-year-old man presented with bilateral cervical lymph node swelling and low fever. Swollen lymph node was biopsied, and diagnosed as nodular sclerosing Hodgkin's disease (HD). By combined radio- and chemotherapy, he went into complete remission. After 3 years, fever of 38-39.2 degrees C and lymph node swelling appeared in the para-aortic region and later became systemic. A biopsy was diagnosed as syncytial variant of HD with aid of immunohistochemistry on frozen sections. Large atypical mono- or binucleated cells reacted with anti-interleukin 6 (IL-6) antibody. The patient's disease progressed with fever, and he died 66 months after the onset of disease. A previous biochemical study showed that IL-6 displayed a real relation to the generation of fever. Therefore it is suggested that fever in this patient is related to IL-6.
authors.affiliation: Department of Pathology, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Aozasa
authors.forename: M
authors.initials: M
authors.lastname: Ohsawa
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
mesh_terms: D003131:Combined Modality Therapy; D005334:Fever / Q000209:etiology*; D006689:Hodgkin Disease / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D012074:Remission Induction
chemical_list: D015850:Interleukin-6