title: Contact sensitivity and systemic antibody responses in dairy cows treated with recombinant bovine somatotropin.
abstract: Effects of exogenous bST on humoral and cell-mediated immune responses in lactating dairy cows were determined. The systemic antibody response to human erythrocytes and the cutaneous sensitivity response induced by dinitrochlorobenzene were the immune responses investigated. Cows were treated with either 0, 10.3, or 20.6 mg of bST/d for 266 d starting between wk 4 and 5 of lactation. Systemic immunizations and contact sensitivity were initiated during midlactation, 22 wk after bST treatments began. Hemagglutinating antibody titers and areas under the response profiles were not statistically different for bST-treated versus control cows. The cutaneous sensitivity response was similarly not affected by bST administration. Present antibody titer results agreed with our previous observations that bST did not affect serum IgM concentrations, but the cutaneous sensitivity results were in contrast with our finding of augmented proliferative responsiveness of mitogen-stimulated peripheral blood lymphocytes in bST-treated versus control cows. It is possible that exogenous bST affects some immune processes and lymphocyte subsets and not others. Further research is required to determine the practical significance of the variable immunomodulation elicited by exogenous bST.
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, ON, Canada.
authors.forename: J L
authors.initials: JL
authors.lastname: Burton
authors.forename: B W
authors.initials: BW
authors.lastname: McBride
authors.forename: B W
authors.initials: BW
authors.lastname: Kennedy
authors.forename: J H
authors.initials: JH
authors.lastname: Burton
authors.forename: T H
authors.initials: TH
authors.lastname: Elsasser
authors.forename: B
authors.initials: B
authors.lastname: Woodward
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002417:Cattle / Q000276:immunology*; D003877:Dermatitis, Contact / Q000662:veterinary; D004137:Dinitrochlorobenzene / Q000009:adverse effects; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects*; D006386:Hemagglutination Tests / Q000662:veterinary; D006968:Hypersensitivity, Delayed / Q000662:veterinary; D007111:Immunity, Cellular / Q000187:drug effects; D011994:Recombinant Proteins / Q000009:adverse effects
chemical_list: D004137:Dinitrochlorobenzene; D011994:Recombinant Proteins; D013006:Growth Hormone