Arthritis transferred by cells derived from pre-inflammatory rat synovium.
Different cell populations isolated from rats during the period of latency of adjuvant arthritis were injected into the bloodstream of naive rats to test their ability to transfer articular disorders. Synovium-derived cells (synoviocytes) were able to induce arthritis in 3 out of 4 recipient animals, whereas peripheral blood leukocytes, peritoneal exudate macrophages, lymph node cells, synoviocyte lysates and synoviocytes from control animals were not able to do so. This model of cellular transferred arthritis is associated with antibody titres to hsp65 in rat sera. Our findings suggest a crucial role for synovial cells in the pathogenesis of adjuvant disease, which might be linked to their function as accessory cells.
Ramos-Ruiz
R
R
Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
Bernabeu
C
C
Ariza
A
A
Fernández
J M
JM
Larraga
V
V
López-Bote
J P
JP
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D006360:Heat-Shock Proteins / Q000378:metabolism; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013583:Synovial Membrane / Q000276:immunology*
D006360:Heat-Shock Proteins; D007376:Interleukin-2; D008562:Membrane Glycoproteins