[Systemic plasmacytosis with polyclonal hypergammaglobulinemia and numerous plasma cells in the blood].
We report a patient with systemic plasmacytosis with polyclonal hyperimmunoglobulinemia who at presentation showed a blood and bone marrow picture suggestive of plasma cell leukemia. A 78-year-old woman was admitted to our hospital because of marked hepatosplenomegaly and generalized lymphadenopathy. She had leukocytosis with 42% plasmacytes, and plasma cells were increased also in her bone marrow (32.6%). She had marked polyclonal hyperimmunoglobulinemia with increased IgG, IgA and IgE. IgM and IgD were normal. She complained of cough and dyspnea. Her general condition was too poor to remove a lymph node for pathological examination. After treatment with daunorubicin, vincristine and prednisolone (DVP), her lymphadenopathy diminished rapidly, the immunoglobulins decreased and the plasma cells in her blood disappeared. She achieved a complete remission and has been in good condition without further treatment for 24 months.
Fujiwara
M
M
Department of Internal Medicine, Nagaoka Red Cross Hospital.
Soga
N
N
Kurokawa
I
I
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001772:Blood Cell Count; D003630:Daunorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000188:drug therapy / Q000473:pathology*; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007952:Leukemia, Plasma Cell / Q000175:diagnosis; D010950:Plasma Cells / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D014750:Vincristine; D011239:Prednisolone; D003630:Daunorubicin