Diffusion from gel in brain: modelisation and identification.
A mathematical model is proposed for describing the mechanism of diffusion from gel (Tissucol) into the extracellular space. After diffusion of the antibiotic in one dimension, the gradient concentration was determined with microvoltametric electrodes. These microelectrodes measure the free diffusible form of electroactive antibiotics in the extracellular brain space. The aim of this study was to find simultaneously the coefficient of diffusion and extraction of some antibiotics (in our case the Fotemustin) using the Alienor Algorithm. These coefficients are useful for predicting the concentration gradient into abscesses, fibrin, etc.
Bellagoun
A
A
MEDIMAT, Université P. et M. Curie, Paris, France.
Meulemans
A
A
Cherruault
Y
Y
D000465:Algorithms; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D001825:Body Fluid Compartments / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D003198:Computer Simulation; D004058:Diffusion; D004337:Drug Carriers; D005110:Extracellular Space / Q000378:metabolism; D015718:Fibrin Tissue Adhesive; D008954:Models, Biological; D051381:Rats; D012016:Reference Values
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D015718:Fibrin Tissue Adhesive