[Long-term results of corpus cavernosum auto-injection therapy in treatment of patients with chronic erectile dysfunction].
From May 1985 to July 1989, 143 patients suffering from chronic erectile dysfunction (21-70 years old) underwent constant corpus cavernosum auto-injection therapy (CCAT) with papaverine alone (1257 injections) or with a standardized papaverine-phentolamine mixture (11035 injections). On the basis of these 12,292 protocol auto-injections and over 4 years' experience with intracavernosal auto-injection therapy we conclude: CCAT, especially with the papaverine-phentolamine mixture, constitutes an effective therapy (full rigidity in 95.9%) with tolerable side-effects for chronic erectile dysfunction when preceded by careful patient selection and thorough multidisciplinary evaluation, especially in the case of arterial and/or neurogenic aetiology of the erectile dysfunction; in addition, the contraindications must be strictly observed, the treatment and technique fully explained, and a regular system instituted. CCAT is generally well accepted by the patients and their partners (100%/98.3%) and has distinct positive effects on self-esteem (77.8%), performance anxiety (84.4%) and partnership (79.5%). The most serious side-effect was prolonged erection (25 out of 12,292 injections). In 3 patients reversible fibrotic changes near the tunica albuginea were observed.
Gall
H
H
Dermatologische Abteilung, Bundeswehrkrankenhaus Ulm.
Sparwasser
C
C
Bähren
W
W
Scherb
W
W
Holzki
G
G
Irion
R
R
D004305:Dose-Response Relationship, Drug; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D007267:Injections; D008134:Long-Term Care; D008297:Male; D008393:Marriage / Q000523:psychology; D010208:Papaverine / Q000008:administration & dosage* / Q000009:adverse effects; D010342:Patient Acceptance of Health Care; D010410:Penile Erection / Q000187:drug effects*; D010411:Penile Induration / Q000139:chemically induced; D010646:Phentolamine / Q000008:administration & dosage* / Q000009:adverse effects; D012649:Self Concept
D010208:Papaverine; D010646:Phentolamine
Langzeitergebnisse der Schwellkörperautoinjektionstherapie bei der Behandlung von Patienten mit chronisch erektiler Dysfunktion.