[Blood coagulation, fibrinolysis and various values of Lansbury's activity index in rheumatoid arthritis patients].
To clarify pathophysiological significance of blood coagulation and fibrinolysis in rheumatoid arthritis (RA) patients with various values of Lansbury's activity index, we analysed by means of the urokinase activated platelet rich plasma thromboelastography. In RA patients, coagulation time (k) and reaction time (r)+k were shorter, maximal amplitude (ma) was larger and lysis time (LT) was longer comparing with those in healthy control. Especially LT and ma showed marked differences between RA patients and control subjects. The mild RA patients whose Lansbury's activity indexes were 0-19% had significant differences from healthy control subjects, in order of LT less than ma less than r+less than k, the probability values were smaller. Significant coefficients of positive correlations with Lansbury's activity index were higher in order of LT greater than LT/k greater than ma x LT. These findings suggested that RA patients had fibrin formation, which had close relations with maximal amplitude (ma) and lysis time (LT) which had positive correlation with Lansbury's activity index.
Motohashi
Y
Y
Center for the Rheumatic Diseases, Maebashi Red Cross Hospital, Gunma.
Nakazawa
T
T
D000203:Activities of Daily Living; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000534:rehabilitation; D001777:Blood Coagulation; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged