Interleukin-1 and interleukin-6 synergize in preparing resting murine B cells to respond to anti-mu: correlation with c-myc expression.
We demonstrate that stimulation with interleukin (IL)-1 and IL-6 prepares high-density B cells to enter the S phase more promptly in response to subsequent stimulation with anti-mu F(ab')2. The stimulatory effect of IL-1 and IL-6 is compared to the one described for IL-4. In contrast to IL-4, preculture in IL-1 and IL-6 does not induce an increase in cell volume or in expression of class II major histocompatibility complex antigens on resting B cells. Similarly, the expression of the p55 subunit of the IL-2 receptor and of the transferrin receptor was not detected on resting B cells stimulated with IL-1 and IL-6. However, the stimulatory effect of IL-1 and IL-6 is correlated with an increased expression of c-myc proto-oncogene mRNA in resting murine B cells.
Escriou
N
N
Unité d'Immunogénétique Cellulaire, Institut Pasteur 25, Paris, France.
Jankovic
D L
DL
Thèze
J
J
D000818:Animals; D000906:Antibodies; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D004357:Drug Synergism; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D016259:Genes, myc / Q000187:drug effects* / Q000276:immunology; D007148:Immunoglobulin mu-Chains / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology / Q000494:pharmacology*; D015850:Interleukin-6 / Q000276:immunology / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008811:Mice, Inbred DBA; D011994:Recombinant Proteins / Q000494:pharmacology
D000906:Antibodies; D007148:Immunoglobulin mu-Chains; D007375:Interleukin-1; D015850:Interleukin-6; D011994:Recombinant Proteins