Hypoplastic/aplastic anemia. Role of bone marrow transplantation.
For young patients with SAA, allogeneic bone marrow transplantation is the best curative approach. Major obstacles to the success of allogeneic bone marrow transplantation include GVHD, infections, and graft rejection. A careful management approach to patients prior to transplant may decrease some of these complications. Immunosuppressive therapy should be utilized in older patients with SAA. Underlying clonal disorders, eg, acute leukemia and recurrent aplasia, are late complications.
Stewart
F M
FM
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville.
D000741:Anemia, Aplastic / Q000175:diagnosis / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods; D003937:Diagnosis, Differential; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy