An analysis of the variation of plasma concentrations of placental protein 14 in artificial cycles.
OBJECTIVE
To analyze the factors affecting the variation of plasma concentration of placental protein 14 (PP14) in artificial cycles.


METHODS
The effects of different hormone replacement therapy (HRT) regimens were examined in a crossover design.


METHODS
Jessop Hospital for Women, Sheffield, United Kingdom.


METHODS
Eighteen women with premature ovarian failure: 6 associated with Turner's syndrome and 12 with idiopathic premature ovarian failure.


METHODS
Four different HRT regimens; 36 study cycles.


METHODS
Plasma PP14 concentrations on days 1, 15, 19, and 29 of the artificial cycles.


RESULTS
In cycles treated with a standard HRT, the levels were similar to those of the natural cycle. Subjects with Turner's syndrome did not have elevated PP14 levels, whereas the majority (9/12 [75%]) of those with idiopathic premature ovarian failure had elevated levels on day 29 of the cycle. Levels of PP14 were reduced when either the doses of estradiol valerate were reduced to 1/3 or the doses of progesterone (P) were reduced to 1/5 of the standard HRT.


CONCLUSIONS
Plasma levels of PP14 are dependent not only on P stimulation but also on adequate estrogen priming.
Li
T C
TC
University of Sheffield, Sheffield City Polytechnic, United Kingdom.
Dalton
C
C
Bolton
A E
AE
Ling
E
E
Warren
A
A
Cooke
I D
ID
D000328:Adult; D004958:Estradiol / Q000097:blood / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood* / Q000187:drug effects; D011257:Pregnancy Proteins / Q000097:blood*; D016649:Primary Ovarian Insufficiency / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood; D012016:Reference Values; D014424:Turner Syndrome / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*
D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone