title: Characterization of an epizootic of pulmonary edema in swine associated with fumonisin in corn screenings.
abstract: In 1989, corn screenings were associated with acute interstitial pulmonary edema, hydrothorax, and death in swine. Attack rate was 5-50%, case fatality rate was 50-90%, and clinical course was 1-2 days. Screenings from farms with pigs affected with pulmonary edema contained 20-330 micrograms fumonisin B1 per gram. Screenings containing 92 micrograms fumonisin B1 per gram fed to weanling pigs caused pulmonary edema and death. Sterilized corn inoculated with Fusarium moniliforme and diluted 1:1 with clean corn contained fumonisin B1 (17 micrograms/g) and caused acute pulmonary edema when fed for 5 days. Survivors developed subacute hepatotoxicosis with individual hepatocellular necrosis, hepatomegalocytosis, and increased numbers of mitotic figures. Similar liver lesions occurred in pigs given fumonisin B1 intravenously at 0.8 mg/kg body weight for 14 days.
authors.affiliation: Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Iowa State University, Ames 50011.
authors.forename: G D
authors.initials: GD
authors.lastname: Osweiler
authors.forename: P F
authors.initials: PF
authors.lastname: Ross
authors.forename: T M
authors.initials: TM
authors.lastname: Wilson
authors.forename: P E
authors.initials: PE
authors.lastname: Nelson
authors.forename: S T
authors.initials: ST
authors.lastname: Witte
authors.forename: T L
authors.initials: TL
authors.lastname: Carson
authors.forename: L G
authors.initials: LG
authors.lastname: Rice
authors.forename: H A
authors.initials: HA
authors.lastname: Nelson
mesh_terms: D000821:Animal Feed / Q000032:analysis / Q000506:poisoning*; D000818:Animals; D003645:Death, Sudden / Q000209:etiology / Q000662:veterinary; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D005516:Food Microbiology; D037341:Fumonisins; D005670:Fusarium / Q000302:isolation & purification / Q000378:metabolism; D007087:Illinois / Q000453:epidemiology; D007484:Iowa / Q000453:epidemiology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D009183:Mycotoxins / Q000032:analysis / Q000506:poisoning*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality; D003313:Zea mays
chemical_list: D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1