title: Total intravenous anaesthesia for direct laryngoscopy: propofol infusion compared to thiopentone combined with midazolam and methohexitone infusion.
abstract: Total intravenous anaesthesia for direct laryngoscopy was investigated in 40 patients, randomized into four groups of 10 patients each. First, propofol infusion was compared to thiopentone combined with midazolam. Next, a comparison of propofol infusion with methohexitone infusion was undertaken. The propofol group showed significantly lower peroperative blood pressure compared to the thiopentone/midazolam group. The second propofol group required significantly less alfentanil to stabilize the blood pressure, compared to the methohexitone group. Completeness of recovery, assessed by means of a coin counting test, was faster in the propofol group compared to the thiopentone/midazolam group, while no difference could be demonstrated between the second propofol group and the methohexitone group. It is concluded that propofol seems to be superior to both thiopentone/midazolam and methohexitone with respect to the stability of peroperative blood pressure. Concerning recovery, propofol is superior to thiopentone/midazolam, but offers no advantage over methohexitone.
authors.affiliation: Department of Anesthesia, Gentofte University Hospital, Denmark.
authors.forename: N M
authors.initials: NM
authors.lastname: Sonne
authors.forename: T G
authors.initials: TG
authors.lastname: Clausen
authors.forename: N
authors.initials: N
authors.lastname: Valentin
authors.forename: S
authors.initials: S
authors.lastname: Halck
authors.forename: A
authors.initials: A
authors.lastname: Munksgaard
mesh_terms: D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D007828:Laryngoscopy; D008297:Male; D008723:Methohexital; D008874:Midazolam; D008875:Middle Aged; D015742:Propofol; D013874:Thiopental
chemical_list: D008723:Methohexital; D013874:Thiopental; D008874:Midazolam; D015742:Propofol