title: Effects of clonidine-induced hypotension and dopamine-induced hypertension on blood flows in prostatic adenocarcinoma (Dunning R3327) and normal tissues.
abstract: In the present study it was investigated whether hypertension induced by dopamine or hypotension induced by clonidine could influence the relative blood distribution in a s.c. transplanted prostatic adenocarcinoma in relation to blood flow in normal tissues in rats. The blood flow was measured by using a radioactive microspheres technique. A bolus injection of 5 micrograms clonidine caused a decrease in the systemic blood pressure with 15-45 mm Hg, and blood flow to the central parts of the tumor, decreased with more than 50%. In the prostate, testes and ileo-psoas muscle a similar reaction was seen. During an infusion of 95-120 micrograms/kg/min dopamine, the blood pressure increased with 15-30 mm Hg, but the blood flow to the tumor was unchanged. However, in the testes and kidneys a decreased blood flow was observed. Moreover, mean blood flow to the central parts of the tumor decreased with increase in tumor size. The results further indicated that hyper- or hypotension or concomitantly given vasoactive drugs with the specific cancer treatment can have unwarranted effects on the distribution of cytotoxic drugs and oxygenation of the tumor.
authors.affiliation: Department of Oncology, University Hospital, Umeå, Sweden.
authors.forename: O
authors.initials: O
authors.lastname: Jonsson
authors.forename: A
authors.initials: A
authors.lastname: Widmark
authors.forename: K
authors.initials: K
authors.lastname: Grankvist
authors.forename: J E
authors.initials: JE
authors.lastname: Damber
authors.forename: R
authors.initials: R
authors.lastname: Henriksson
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D011467:Prostate / Q000098:blood supply*; D011471:Prostatic Neoplasms / Q000098:blood supply*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D003000:Clonidine; D004298:Dopamine