title: [A reproductive study of Weiser-Maples guinea pigs].
abstract: The Weiser-Maples (WE) guinea pig strain was introduced by Backshire Co., Ltd. (USA) in 1977. We have been breeding WE strain guinea pigs for skin melanization research. The WE guinea pig colony produced 1271 pups in 417 litters from May 1978 through December 1983. Breeding date are shown below. The mean litter size was 3.05, the stillborn rate was 15.2%, the weaning rate for live-born pups was 93.5% and the sex ratio was 1.01. The average age at first vaginal membrane rupture was 31.4 days at which time body weight was 290.5g. The mean length of the first 7 estrous cycles was about 17 days, with no cyclical variation in length. The mean duration of gestation was 67.9 days. Duration of pregnancy varied with litter size. There was an inverse relationship between litter size and duration of pregnancy. Most of the pups were delivered alive in mid-pregnancy with a parturition range of 56 to 76 days. The probability of pup death depends on gestational length: the lowest incidence of mortality was seen in litters born at 70 days. The mortalities were related to litter size but not to parity. There was an inverse relationship between birth weight and litter size. In WE guinea pigs, the mean weight for a litter of 1 was 120 g; for a litter of 5, the mean body weight was 58g. Male body weights were slightly heavier than female at birth and at weaning age. The mean body weights are shown below, date of birth: female 88.3g, male 93.3g, weaning age (2 weeks): female 181.1g, male 198.8g and 30 weeks: female 758.7g, male 1018.0g. These date for WE guinea pigs are comparable to those of other strains.
authors.affiliation: Shiseido Co., Ltd., Safety and Analytical Research Center, Kanagawa, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Inaba
authors.forename: Y
authors.initials: Y
authors.lastname: Wakisaka
mesh_terms: D000818:Animals; D001724:Birth Weight; D004971:Estrus; D005260:Female; D005865:Gestational Age; D006128:Growth; D006168:Guinea Pigs / Q000502:physiology*; D008098:Litter Size; D008297:Male; D008423:Maternal Age; D009929:Organ Size; D010298:Parity; D011247:Pregnancy; D012098:Reproduction