title: [Mast cells in the focus of an acute infectious inflammation].
abstract: On the model of E. coli-induced acute infectious peritonitis in rats it is established that the mast cell reaction and histamine level increase in exudate and inflamed mesentery tissue are biphase and are observed predominantly following the inflammatory agent action, in the period corresponding to the immediate phase of peritoneal cavity vessel permeability increases. The preliminary elimination of mast cells significantly inhibits a rise in the vascular permeability in the immediate phase and slightly affects the delayed phase, thus prolonging exudation. At the same time the dynamics of free histamine indicates its direct involvement in mediation and/or modulation as well as in subsequent inflammatory events. The common rules of mast cell involvement and vascular permeability increase in infectious and aseptic inflammation have been shown.
authors.forename: M O
authors.initials: MO
authors.lastname: Klymenko
authors.forename: S V
authors.initials: SV
authors.lastname: Tatarko
mesh_terms: D000208:Acute Disease; D000818:Animals; D001202:Ascitic Fluid / Q000737:chemistry / Q000166:cytology / Q000503:physiopathology; D002199:Capillary Permeability / Q000502:physiology; D004927:Escherichia coli Infections / Q000503:physiopathology*; D005490:Focal Infection / Q000503:physiopathology*; D006632:Histamine / Q000032:analysis / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D008643:Mesentery / Q000737:chemistry / Q000503:physiopathology; D010538:Peritonitis / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006632:Histamine
vernacular_title: Tuchni klityny u vohnyshchi hostroho infektsiĭnoho zapaleniia.