Acute renal failure following hemorrhagic shock: protective and aggravating factors.
Acute renal failure following hemorrhagic shock was studied in awake rats. The animals were bled to maintain the mean arterial blood pressure between 40 and 60 mm Hg during 180 min. After this period, the blood was reinfused and the rats were studied 24 h later. Hemorrhagic shock caused a less intensive renal injury than 60-min bilateral renal artery clamping. Renal function in the latter model was worse (p less than 0.05) as shown by serum creatinine (SCr) (0.75 +/- 0.10 vs 1.2 +/- 0.2 mg/dL), blood urea nitrogen (BUN) (26.0 +/- 2.8 vs 53.0 +/- 8.5 mg/dL), fractional excretion of sodium (FENa, %) (0.3 +/- 0.1 vs 1.8 +/- 1.0) and potassium (FEK, %) (41.4 +/- 5.7 vs 76.3 +/- 14.2) and urine/plasma creatine (U/PCr (86.4 +/- 15.7 vs 38.8 +/- 15.5). The rats which received verapamil (10 micrograms/kg/min) prior and during the HS did not show increase in SCr (0.5 +/- 0.06 vs 0.75 +/- 0.1 mg/dL, p less than 0.05). This effect was also observed in the rats which received intravenous allopurinol (40 mg/kg) before HS, SCr did not increase (0.5 +/- 0.04 vs 0.75 +/- 0.1 mg/dL, p = 0.05), suggesting a protective effect of those substances in HS.(ABSTRACT TRUNCATED AT 250 WORDS)
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Laboratório de Pesquisa Básica da Disciplina de Nefrologia, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Seguro
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Rocha
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D058186:Acute Kidney Injury / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D000493:Allopurinol / Q000627:therapeutic use; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003681:Dehydration / Q000150:complications; D005609:Free Radicals; D005839:Gentamicins / Q000009:adverse effects; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000517:prevention & control; D012771:Shock, Hemorrhagic / Q000150:complications*; D014700:Verapamil / Q000627:therapeutic use
D005609:Free Radicals; D005839:Gentamicins; D000493:Allopurinol; D014700:Verapamil; D002118:Calcium