title: The role of interleukin-6 in vitamin A deficiency during Plasmodium falciparum malaria and possible consequences for vitamin A supplementation.
abstract: Kinetics of serum levels of interleukin-6 (IL-6) were studied in patients with acute Plasmodium falciparum malaria in relation to vitamin A and its binding proteins, retinol binding protein (RBP) and pre-albumin. It was found that IL-6 levels followed the rise and decrease of parasitaemia by 12 hr and correlated inversely with levels of vitamin A and its binding proteins. These data suggest that vitamin A supplementation alone might still be insufficient to restore a malaria-induced vitamin A deficiency.
authors.affiliation: INSERM U 313, Hôpital de la Salpétrière, Paris, France.
authors.forename: M D
authors.initials: MD
authors.lastname: Tabone
authors.forename: K
authors.initials: K
authors.lastname: Muanza
authors.forename: M
authors.initials: M
authors.lastname: Lyagoubi
authors.forename: C
authors.initials: C
authors.lastname: Jardel
authors.forename: S
authors.initials: S
authors.lastname: Pied
authors.forename: O
authors.initials: O
authors.lastname: Amedee-Manesme
authors.forename: G E
authors.initials: GE
authors.lastname: Grau
authors.forename: D
authors.initials: D
authors.lastname: Mazier
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D016778:Malaria, Falciparum / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014801:Vitamin A / Q000097:blood / Q000627:therapeutic use*; D014802:Vitamin A Deficiency / Q000188:drug therapy / Q000209:etiology*
chemical_list: D015850:Interleukin-6; D014801:Vitamin A