[Carnitine metabolism in chronic kidney failure].
Carnitine plays an important role in regulating the flow of energetic substrates and their balance through cellular membranes. Usually in chronic renal failure, increased plasma levels of carnitine are found. In early hemodialysis a slow decrease of the muscle concentrations of carnitine is found, followed by a decrease of plasma concentrations long after substitutive treatment. Several signs and symptoms are attributable to carnitine deficiency. It is reported that these changes regress with suitable supply of intravenous carnitine after dialysis end for 15-30 days, and subsequently with chronic administration in the dialysis fluid.
Fiorini
F
F
Divisione di Medicina, U.S.L. 2, Sanremese.
Patrone
E
E
Castellucci
A
A
D002331:Carnitine / Q000172:deficiency / Q000378:metabolism* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy; D006435:Renal Dialysis
D002331:Carnitine
Metabolismo della carnitina nell'insufficienza renale cronica.