Captopril ameliorates the posturally induced fall in creatinine clearance in patients with chronic glomerulonephritis.
The clinical usefulness of an angiotensin-converting enzyme inhibitor on the posturally induced fall in creatinine clearance (ClCr) was studied in patients with biopsy-proved chronic glomerulonephritis (CGN). After a change from supine to upright position, ClCr fell significantly in all patients. This fall was significantly ameliorated by the pretreatment with captopril (fall in ClCr 28.8 +/- 14.3% for nontreated vs 16.5 +/- 11.5% for treated patients; n = 12; p less than 0.05). The ameliorating effect was more marked in patients with mesangial cell proliferation (MP) than those without it (fall in ClCr 7.2 +/- 6.3% for MP vs 17.1 +/- 12.3% for no MP; n = 6; p less than 0.05). The results suggest that captopril apparently had a renoprotective effect on the orthostatic acute fall in ClCr in patients with CGN, especially those with MP.
Kuriyama
S
S
Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Shimada
T
T
Hashimoto
T
T
Sakai
O
O
D000328:Adult; D002216:Captopril / Q000494:pharmacology*; D002908:Chronic Disease; D003404:Creatinine / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005921:Glomerulonephritis / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011187:Posture; D016683:Supine Position
D002216:Captopril; D003404:Creatinine