Complexation of iron with the orally active decorporation drug L1 (3-hydroxy-1,2-dimethyl-4-pyridinone).
The stability constants for the Fe(III) complexes of the orally active iron decorporation drug L1 (3-hydroxy-1,2-dimethyl-4-pyridinone) have been determined by potentiometric titration [glass electrode, 25.0 degrees C, mu = 0.15 mol/L (isotonic) NaCl]. A simple computer model of blood plasma (citrate 100 mumol/L, transferrin 37 mumol/L) has been used to compare the Fe(III) binding efficacies in blood of L1 and the clinically used intravenously administered chelating agent deferoxamine.
Kline
M A
MA
Department of Chemistry, University of British Columbia, Vancouver, Canada.
Orvig
C
C
D002614:Chelating Agents / Q000378:metabolism*; D003198:Computer Simulation; D000077543:Deferiprone; D003676:Deferoxamine / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000097:blood / Q000378:metabolism*; D011199:Potentiometry; D011728:Pyridones / Q000097:blood / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism
D002614:Chelating Agents; D011728:Pyridones; D014168:Transferrin; D000077543:Deferiprone; D007501:Iron; D003676:Deferoxamine