Catecholamine effects on dissociated tiger salamander Muller (glial) cells.
Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell response to the CAs is concentration dependent. At high concentrations ascorbate, an antioxidant used to protect the CAs from oxidation, stimulated a net outward current and a decrease in Rn. When the effects of ascorbate were considered, the CA response at 1 mM was no larger than the response at 100 microM, indicating that 100 microM CA maximally stimulated the Muller cell response.
Henshel
D S
DS
Washington University Medical School, Department of Ophthalmology, St. Louis, MO 63110.
Miller
R F
RF
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology*; D004594:Electrophysiology; D004837:Epinephrine / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D014562:Caudata
D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine