title: Variations in corticomotor and somatosensory evoked potentials: effects of temperature, halothane anesthesia, and arterial partial pressure of CO2.
abstract: The effects of temperature, halothane concentration, and arterial partial pressure of CO2 on corticomotor evoked potentials (CMEPs) and somatosensory evoked potentials (SSEPs) were studied. Hypothermia causes an increase in CMEP and SSEP latencies. Corticomotor evoked potential amplitude increases with hypothermia to reach a maximum at or below 28 degrees C. As the temperature decreases from 42 degrees C, SSEP amplitude initially increases to reach a maximum between 36 and 34 degrees C and then decreases with further reductions in temperature. Increased arterial partial pressure of CO2 decreases amplitude and increases latencies of the CMEPs and SSEPs. The concentration of halothane has no effect on CMEP amplitude or latency. However, SSEP amplitude is inversely related to halothane concentration, and SSEP latency is directly related to halothane concentration. These results suggest that physiologic variables must be carefully measured when evoked potentials are utilized in any animal or human study. Moreover, each type of evoked potential has a unique response to alterations of these variables.
authors.affiliation: Department of Surgery, Veterans Affairs Medical Center, Houston, Texas.
authors.forename: J L
authors.initials: JL
authors.lastname: Browning
authors.forename: M L
authors.initials: ML
authors.lastname: Heizer
authors.forename: D S
authors.initials: DS
authors.lastname: Baskin
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006221:Halothane / Q000494:pharmacology*; D007035:Hypothermia / Q000378:metabolism*; D008297:Male; D010313:Partial Pressure
chemical_list: D002245:Carbon Dioxide; D006221:Halothane