The effect of subacute prazosin treatment on hepatic metabolic enzyme system of young and elderly rats.
We have studied cytochrome P-450 content, aminopyrine-N-demethylating activity, serum bilirubin level, in young 10 weeks old and elderly, 14 months old CFY rats grouped according to sex. The effect of the selective alpha 1-adrenoceptor antagonist antihypertensive prazosin was examined in the previously described groups of animals. We could state that neither oxidative nor conjugative reactions of the liver declined with aging. In a subacute 12 days treatment period prazosin has not impaired liver functions.
Gergely
J
J
University Medical School of Debrecen, Department of Pharmacology, Hungary.
Kulcsár
A
A
D000375:Aging / Q000378:metabolism; D000633:Aminopyrine N-Demethylase / Q000187:drug effects; D000818:Animals; D001663:Bilirubin / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats
D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D001663:Bilirubin; D011224:Prazosin