title: The rabbit jejunal 'imino carrier' and the ileal 'imino acid carrier' describe the same epithelial function.
abstract: For rabbit jejunal brush border vesicles an 'imino carrier' has been defined as a sodium-dependent, alanine-resistant transporter of cyclic imino acids, while for intact rabbit jejunal and ileal epithelia an 'imino acid carrier' has been defined as a sodium-dependent transporter of both aliphatic and cyclic imino acids. This study on intact rabbit intestine examines whether these two terms describe the same epithelial function. The KPro1/2 and the KProi against JMeAIBmc are identical and so are KMeAIB1/2 and KMeAIBi against JPromc. Likewise, KLeui is the same against the transport of both proline and MeAIB. It is, therefore, concluded that the terms 'imino carrier' and 'imino acid carrier' describe the same epithelial function: A sodium-dependent, relatively high afinity, saturable transporter of both aliphatic and cyclic imino acids. Estimates of the apparent affinity and inhibitory constants for MeAIB, proline and leucine confirm that the jejuno-ileal variation of amino acid transport along the rabbit small intestine is a variation of maximal transport capacity.
authors.affiliation: Department of Medicine F, Gentofte Hospital, University of Copenhagen, Denmark.
authors.forename: L K
authors.initials: LK
authors.lastname: Munck
authors.forename: B G
authors.initials: BG
authors.lastname: Munck
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D007082:Ileum / Q000378:metabolism*; D007098:Imino Acids / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D007700:Kinetics; D008871:Microvilli / Q000378:metabolism*; D011392:Proline / Q000494:pharmacology; D011817:Rabbits; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000596:Amino Acids; D002352:Carrier Proteins; D007098:Imino Acids; D015091:beta-Alanine; C012924:2,2-dimethyl-beta-alanine; D011392:Proline