Simplified experimental human dermatophytosis model.
The authors have improved and simplified previous methods for producing localized mycotic skin infections in an attempt to compare topical antifungal agents for their bioequivalency. Healthy human volunteers who had negative results for commercial, purified Trichophyton antigen (Trichophytin) were inoculated with Trichophyton mentagrophytes on two sites on each forearm in a randomized study designed to compare the antifungal activities of two ciclopirox olamine formulations. The lesions, easily induced by the authors' method, were localized and did not spread under the occlusive dressings. Infections established at the four sites on 26 subjects were treated twice daily for 14 days with the two active drug formulations and their vehicles. There were no significant differences in culture-documented cure rates or alleviation of clinical signs and symptoms between ciclopirox olamine lotion and cream. Each drug was significantly better than its vehicle. The authors' method seems to be effective and suitable for therapeutic studies.
Aly
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Department of Dermatology, University of California Medical Center, San Francisco.
Maibach
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Ho
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Abrams
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BB
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077768:Ciclopirox; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D009824:Ointments; D011728:Pyridones / Q000008:administration & dosage / Q000627:therapeutic use*; D013535:Suspensions; D014005:Tinea / Q000188:drug therapy*; D014249:Trichophyton / Q000187:drug effects*
D000935:Antifungal Agents; D009824:Ointments; D011728:Pyridones; D013535:Suspensions; D000077768:Ciclopirox