title: Understanding anticancer drug resistance: opportunities for modulation and impact on new drug design.
abstract: As our understanding of the mechanisms of cytotoxic drug resistance improves, it becomes feasible to circumvent this resistance through the rational design of non cross-resistant analogues or modulation of existing agents. Although this knowledge has yet to make a major impact on the success of cancer therapy, there are good reasons to be optimistic that this increased knowledge will be translated into more effective therapy in the future.
authors.affiliation: Drug Development Section, Institute of Cancer Research, Sutton, Surrey, U.K.
authors.forename: I R
authors.initials: IR
authors.lastname: Judson
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004260:DNA Repair; D015195:Drug Design; D004351:Drug Resistance; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins