Markers of a hypercoagulable state following acute ischemic stroke.
OBJECTIVE
The nature of hematologic disorders in different stroke subtypes remains uncertain. The purpose of this study was to clarify the differences in the coagulation and fibrinolytic activities among ischemic stroke subtypes.


METHODS
We performed sequential measurements of hematologic parameters in 21 patients with acute cardioembolic stroke, 10 patients with atherothrombotic stroke, 23 patients with lacunar stroke, and 20 age-matched controls.


RESULTS
A marked elevation of plasma concentrations of the thrombin-antithrombin III complex and crosslinked D-dimer was observed only in cardioembolic stroke within 48 hours of onset (p less than 0.01), persisting for one month with a gradual decline. In atherothrombotic stroke, however, the level of crosslinked D-dimer was not elevated at the onset, but increased seven days after onset (p less than 0.01). No significant changes in these marker levels were observed in lacunar stroke.


CONCLUSIONS
Our findings suggest that the nature of altered coagulation and fibrinolysis are different in various subtypes of ischemic stroke, and that an assessment of these hematologic parameters may be useful for the early classification of these subtypes.
Takano
K
K
Department of Medicine, National Cardiovascular Center, Osaka, Japan.
Yamaguchi
T
T
Uchida
K
K
D000208:Acute Disease; D000990:Antithrombin III / Q000032:analysis; D015415:Biomarkers; D001778:Blood Coagulation Disorders / Q000209:etiology*; D002545:Brain Ischemia / Q000097:blood / Q000150:complications*; D002561:Cerebrovascular Disorders / Q000097:blood / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000032:analysis
D015415:Biomarkers; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases