title: Absence of food effects on the pharmacokinetics of terfenadine.
abstract: Administration of terfenadine (Seldane) immediately after a high fat breakfast slightly affects the rate but not the extent of absorption relative to fasting administration. Mean peak levels of the active metabolite were increased by 13 per cent but delayed by 0.9 h while AUC was virtually the same as when terfenadine was administered while fasting. Changes in rate of absorption may be due to delayed gastric emptying and more rapid terfenadine solubilization. In any case, these rate differences are unlikely to be clinically important in the absence of differences in extent of absorption.
authors.affiliation: Marion Merrell Dow Inc., Cincinnati, OH 45215.
authors.forename: M G
authors.initials: MG
authors.lastname: Eller
authors.forename: B J
authors.initials: BJ
authors.lastname: Walker
authors.forename: L
authors.initials: L
authors.lastname: Yuh
authors.forename: K K
authors.initials: KK
authors.lastname: Antony
authors.forename: B E
authors.initials: BE
authors.lastname: McNutt
authors.forename: R A
authors.initials: RA
authors.lastname: Okerholm
mesh_terms: D000328:Adult; D001682:Biological Availability; D004041:Dietary Fats / Q000008:administration & dosage*; D005215:Fasting / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D016593:Terfenadine / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*
chemical_list: D004041:Dietary Fats; D016593:Terfenadine