title: Large parathyroid functioning carcinoma (1,200 g) presenting as a substernal goiter.
abstract: Parathyroid carcinoma is a rare tumor responsible for 0.5-5% of primary hyperparathyroidism. It is usually small (not more than 27 g) and the precise diagnosis of malignancy is made when local or distant metastases are found. We describe a case of a 37 yr old male presenting with a substernal goiter and no specific symptoms except hypertension. This mass had cysts and calcifications and it was in the anterior upper mediastinum. The patient had severe hypercalcemia (Ca greater than 14 mg/dl), high PTH levels and mild renal failure. Bone scanning showed signs of hyperparathyroidism. The patient was subjected to total thyroidectomy and removal of the mass en block. The tumor was circumscribed lobulated and mostly cystic. It weighed 1,200 g (380 g after evacuation of cysts) and measured 12 x 9 x 4.5 cm. Histologic examination showed a highly differentiated adenocarcinoma of parathyroid with metastasis in a regional lymph node. Almost 4 years later the patient is alive and well without hypercalcemia and without evidence of distant metastases.
authors.affiliation: Department of Endocrinology, Hippokration Hospital, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Avramides
authors.forename: K
authors.initials: K
authors.lastname: Papamargaritis
authors.forename: A
authors.initials: A
authors.lastname: Antoniadis
authors.forename: D
authors.initials: D
authors.lastname: Gakis
authors.forename: M
authors.initials: M
authors.lastname: Leontsini
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D002291:Carcinoma, Papillary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D006042:Goiter / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D006961:Hyperparathyroidism / Q000150:complications; D008297:Male; D010282:Parathyroid Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology