title: Study of the biological and prognostic significance of the antigen CaMBr8 on breast carcinoma.
abstract: We previously reported that the expression on the primary tumour of the antigen CaMBr8 was related to a short survival, attributable either to higher tumour aggressiveness or a poor response to oophorectomy. To further verify the CaMBr8 prognostic value, we analysed retrospectively 862 breast cancer patients with a 19 year follow-up. In this series, CaMBr8 expression was found to be associated to some negative prognostic factors (premenopausal status, lymphnode invasion, a high number of mitosis and HER-2/neu oncoprotein expression), but had no influence on the patients' survival. Direct association with a poor prognosis was only evident in patients with lobular or mixed breast carcinoma, which however represent only a small fraction of the total breast cancers. Another possibility was that CaMBr8 could identify a subgroup of patients which did not respond to hormone therapy. To verify this hypothesis we evaluated on a second series of 116 patients the relationship between CaMBr8 expression and hormone-receptor levels. A negative association emerged which was also observed in vitro in the human breast cancer line MCF-7 treated with Sodium Butyrate, a differentiation inducer, which reduced hormone-receptor levels and increased CaMBr8 expression. In conclusion, the longer survival of CaMBr8 negative tumour patients observed in the initial study, was probably related to a better response to oophorectomy, due to the hormone-receptor level of their tumours.
authors.affiliation: Experimental Oncology E, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Facheris
authors.forename: F
authors.initials: F
authors.lastname: Perrone
authors.forename: S
authors.initials: S
authors.lastname: Ménard
authors.forename: S
authors.initials: S
authors.lastname: Andreola
authors.forename: P
authors.initials: P
authors.lastname: Bazzini
authors.forename: R
authors.initials: R
authors.lastname: Bufalino
authors.forename: S
authors.initials: S
authors.lastname: Canevari
authors.forename: N
authors.initials: N
authors.lastname: Cascinelli
authors.forename: E
authors.initials: E
authors.lastname: Colzani
authors.forename: G
authors.initials: G
authors.lastname: Di Fronzo
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000276:immunology* / Q000401:mortality*; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone