title: [Free radicals in clinical biology. Origin, pathogenic effect and defense mechanisms].
abstract: Free radicals are chemical species with an unpaired electron on their outer orbit. This review discusses the various endogenous and exogenous sources of free radicals; toxicity of free radicals, especially for DNA and cell membranes; a number of pathophysiologic states related to overproduction of free radicals; the natural protective systems--involving enzymes or scavengers--which prevent free radical-induced cell injury, and therapeutic trials of antioxidants for improving protection against free radicals in a number of conditions.
authors.affiliation: Laboratoire de Biochimie, Hôpital Corentin Celton, Issy-Les-Moulineaux, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Fulbert
authors.forename: M J
authors.initials: MJ
authors.lastname: Cals
mesh_terms: D001161:Arteriosclerosis / Q000139:chemically induced*; D002338:Carotenoids / Q000378:metabolism; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D005609:Free Radicals / Q000009:adverse effects / Q000032:analysis / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism; D009369:Neoplasms / Q000139:chemically induced*; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
chemical_list: D005609:Free Radicals; D008563:Membrane Lipids; D014810:Vitamin E; D002338:Carotenoids; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
vernacular_title: Les radicaux libres en biologie clinique: origine, rôle pathogène et moyens de défense.