title: Expression of IL-2 receptor/p75 on lymphocytes from patients with rubella.
abstract: We analyzed the Interleukin-2 receptor (IL-2R) expression on fresh lymphocytes from three patients with rubella. Flow cytometric analysis demonstrated that lymphocytes from the patients expressed a considerable amount of IL-2R/p75 recognized by Mik-beta 1 monoclonal antibody (MoAb), although they did not react with anti-IL-2R/p55 (CD25) MoAb. The expression of IL-2R/p75 reached a peak at the end of the acute phase of illness. Fresh lymphocytes from rubella patients showed a marked proliferative response to IL-2, which was completely inhibited by Mik-beta 1, indicating that their IL-2R is a functional receptor. The present data suggest that IL-2R/p75 expression is involved in the host immune response triggered by the rubella virus.
authors.affiliation: Department of Pediatrics, Mie University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Komada
authors.forename: K
authors.initials: K
authors.lastname: Oitani
authors.forename: Y W
authors.initials: YW
authors.lastname: Zhou
authors.forename: S L
authors.initials: SL
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000378:metabolism*; D012409:Rubella / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D015375:Receptors, Interleukin-2