title: Neonatal lupus erythematosus in Japan.
abstract: BACKGROUND
  Although more than 200 cases of neonatal lupus erythematosus (NLE) have been reported, the prognosis, clinical characteristics, and genetic background of the patients are still obscure. Their symptoms seem to vary in different races.
  
  
  OBJECTIVE
  We had an opportunity to see two clinically different types of NLE. It is important to define the clinical characteristics in Japanese cases and to compare them to caucasian NLE cases reported earlier.
  
  
  METHODS
  Sixty Japanese infants with NLE and their mothers reported in Japan were investigated and compared with cases reported from other countries.
  
  
  RESULTS
  Japanese cases were highly associated with anti-SS-A/Ro, anti-SS-B/La, anti-ribonuclear protein, and anti-DNA antibodies. A low frequency of congenital heart block was noted but 8.3% of the cases progressed to systemic lupus erythematosus. HLA-DRw12 was a significantly relative risk in NLE.
  
  
  CONCLUSIONS
  The clinical characteristics of Japanese NLE patients were different from those of caucasian patients reported in the literature.
authors.affiliation: Department of Dermatology, Fukushima Medical College, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Kaneko
authors.forename: O
authors.initials: O
authors.lastname: Tanji
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Ohto
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D008179:Lupus Erythematosus, Discoid / Q000150:complications / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology; D008297:Male; D011379:Prognosis
chemical_list: D000974:Antibodies, Antinuclear; D006680:HLA Antigens