title: Naloxone-associated patient violence: an overlooked toxicity?
abstract: OBJECTIVE
  To report two cases of a previously unreported adverse effect, violent patient behavior, after the reversal of sedation by intravenous naloxone.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Responses of two individuals who had reversal of sedation by intravenous naloxone are compared.
  
  
  RESULTS
  Placement of patient restraints before the administration of intravenous naloxone to obtunded or unconscious patients can make an important contribution to the safety of patients, healthcare personnel, and public safety personnel, as illustrated by the violent reaction of one unrestrained patient after naloxone administration.
  
  
  CONCLUSIONS
  Patient restraint should be considered before naloxone administration to protect the patient and healthcare workers. In the prehospital setting, limiting the use of naloxone to patients with decreased mental status and respiratory depression would decrease the likelihood of naloxone-induced violent behavior.
authors.affiliation: Department of Emergency Medicine, School of Medicine, University of Missouri-Kansas City.
authors.forename: G M
authors.initials: GM
authors.lastname: Gaddis
authors.forename: W A
authors.initials: WA
authors.lastname: Watson
mesh_terms: D000328:Adult; D002606:Charcoal / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009270:Naloxone / Q000008:administration & dosage / Q000009:adverse effects*; D014754:Violence
chemical_list: D002606:Charcoal; D009270:Naloxone