Evaluation of the haemostatic profile in the pre- and post parturient mare, with particular focus on the perinatal period.
Various haemostatic analytes were systematically evaluated for four months pre-partum and five months post partum in 14 healthy mares. The plasma fibrinogen concentration and both Factor VIII:C and von Willebrand factor activity showed gradual increases from mid-gestation and reached maximal, or near maximal activity at parturition. These increases were paralleled by an increase in plasma fibronectin concentration, the appearance of fibrinogen degradation products, and a modest rise in antithrombin III concentration. In contrast, the activity of Factor VII and Factor IX, and the one-stage prothrombin (PT) time and the activated partial thromboplastin (APTT) time remained relatively constant throughout the pre- and post parturient period.
Gentry
P A
PA
Department of Clinical Pathology and Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Feldman
B F
BF
O'Neill
S L
SL
Madigan
J E
JE
Zinkl
J G
JG
D000818:Animals; D000990:Antithrombin III / Q000032:analysis; D005069:Evaluation Studies as Topic; D005164:Factor IX / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005353:Fibronectins / Q000032:analysis; D006487:Hemostasis; D006736:Horses / Q000097:blood*; D010314:Partial Thromboplastin Time / Q000662:veterinary; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*; D011517:Prothrombin Time / Q000662:veterinary; D014841:von Willebrand Factor / Q000032:analysis
D005338:Fibrin Fibrinogen Degradation Products; D005353:Fibronectins; D014841:von Willebrand Factor; D000990:Antithrombin III; D005167:Factor VII; D005169:Factor VIII; D005164:Factor IX; D005340:Fibrinogen