title: In vivo T1 values from guinea pig brain depend on body temperature.
abstract: T1 and T2 values were calculated from guinea pig brain in vivo at 0.5 T. T1 values showed significant dependence on body temperature, but the effect varied significantly from animal to animal and from one tissue type to another. Mean dependencies were 8.2 ms/degrees C for corpus callosum, 14.7 ms/degrees C for gray matter, and 21.5 ms/degrees C for hemispheric white matter (1.7, 2.6, and 4.5%/degrees C, respectively), all with respect to core temperature. These findings suggest that body temperature monitoring and control may be needed when sensitive measurements of T1 are being made. There was evidence for regulation of brain temperature within the hyperthermic range of body temperature.
authors.affiliation: Multiple Sclerosis NMR Research Group, Institute of Neurology, London, United Kingdom.
authors.forename: B D
authors.initials: BD
authors.lastname: Youl
authors.forename: C P
authors.initials: CP
authors.lastname: Hawkins
authors.forename: J K
authors.initials: JK
authors.lastname: Morris
authors.forename: E P
authors.initials: EP
authors.lastname: DuBoulay
authors.forename: P S
authors.initials: PS
authors.lastname: Tofts
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D003337:Corpus Callosum / Q000033:anatomy & histology / Q000502:physiology; D006168:Guinea Pigs; D006979:Hyperthermia, Induced; D007036:Hypothermia, Induced; D008279:Magnetic Resonance Imaging