[Suramin induces lysosomal storage disorder in HT29-D4 cells during a mechanism of polarized endocytosis].
During the course of suramin-induced differentiation, a marked lysosomal storage disorder is observed in HT29-D4. This impairment could account for the toxic side effects of the drug during clinical trials in humans. It is shown that the perturbation is caused by a process of endocytosis of suramin-serum albumin complexes by the apical membrane of differentiated HT29-D4 cells.
Baghdiguian
S
S
Lab. d'Histologie, Fac. de Médecine Secteur Nord, Marseille.
Boudier
J A
JA
Verrier
B
B
Zappitelli
J P
JP
Fantini
J
J
D000230:Adenocarcinoma / Q000473:pathology; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D004705:Endocytosis / Q000187:drug effects*; D016464:Lysosomal Storage Diseases / Q000139:chemically induced* / Q000473:pathology; D013498:Suramin / Q000009:adverse effects*; D014407:Tumor Cells, Cultured / Q000473:pathology
D013498:Suramin
La suramine provoque une perturbation du système lysosomal des cellules HT29-D4 au cours d'un mécanisme d'endocytose polarisée.