Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice.
The anticarcinogenic effect of dietary turmeric on benzo[a]pyrene-(BP) induced forestomach neoplasia and 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin tumorigenesis in female Swiss mice was evaluated. To further elucidate the mechanism of antineoplastic action of turmeric, its effect on the hepatic cytochrome b5, cytochrome P-450, glutathione, and glutathione S-transferase activities was studied in female Swiss mice. Turmeric (2% or 5%) in the diet significantly inhibited the BP-induced forestomach tumors, and this response was dose and time dependent. The 2% turmeric diet significantly suppressed DMBA-induced skin tumors in mice. The 5% turmeric diet for seven consecutive days resulted in a 38% decrease in the hepatic cytochrome b5 and cytochrome P-450 levels. Glutathione content was increased by 12%, and the glutathione S-transferase activity was enhanced by 32% in the liver. Our results document a protective effect of turmeric on BP-induced forestomach and DMBA-induced skin tumors in mice.
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Carcinogenesis Division, Tata Memorial Centre, Parel, Bombay, India.
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D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001564:Benzo(a)pyrene; D003474:Curcumin / Q000494:pharmacology*; D004032:Diet; D005260:Female; D005982:Glutathione Transferase / Q000032:analysis; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D001564:Benzo(a)pyrene; D015127:9,10-Dimethyl-1,2-benzanthracene; D005982:Glutathione Transferase; D003474:Curcumin