title: Cardiovascular effects and fatalities associated with intravenous administration of doxycycline to horses and ponies.
abstract: Intravenous use of doxycycline in horses is associated with deleterious side effects on the cardiovascular system which may result in fatalities. At dosages and infusion rates used in these studies, supraventricular tachycardia, systemic arterial hypertension, clinical signs of discomfort, collapse and death were observed. Results of the present study suggest that the intravenous use of doxycycline should be avoided in horses.
authors.affiliation: Department of Anatomy, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: J L
authors.initials: JL
authors.lastname: Riond
authors.forename: J E
authors.initials: JE
authors.lastname: Riviere
authors.forename: W M
authors.initials: WM
authors.lastname: Duckett
authors.forename: C E
authors.initials: CE
authors.lastname: Atkins
authors.forename: A D
authors.initials: AD
authors.lastname: Jernigan
authors.forename: Y
authors.initials: Y
authors.lastname: Rikihisa
authors.forename: S L
authors.initials: SL
authors.lastname: Spurlock
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004318:Doxycycline / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography / Q000662:veterinary; D004573:Electrolytes / Q000097:blood; D005260:Female; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000502:physiology*; D007262:Infusions, Intravenous / Q000662:veterinary; D008297:Male; D009132:Muscles / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
chemical_list: D004573:Electrolytes; D004318:Doxycycline