The nervous systems of helminths as targets for drugs.
Processes that critically differentiate parasitic helminths and their hosts are obvious candidates for chemotherapeutic intervention. The recognition that neurobiology distinguishes helminths from their vertebrate hosts is due in part to the fact that several efficacious anthelmintics, derived generally from empirical screening, have been found to act selectively on the neuromuscular system of these parasites. In addition, basic physiological and pharmacological research has revealed considerable differences in the ways in which helminths and their hosts transmit information in the nervous system and respond to it in innervated tissues. Unfortunately, most of these differences have yet to be exploited in chemotherapy. The topics for this review include an analysis of mechanistic aspects of the pharmacology of anthelmintics that act on neuromuscular systems and a consideration of the prospects for discovery of novel drugs that act on this system.
Geary
T G
TG
Upjohn Company, Upjohn Laboratories, Kalamazoo, Michigan 49001.
Klein
R D
RD
Vanover
L
L
Bowman
J W
JW
Thompson
D P
DP
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D002589:Cestoda / Q000187:drug effects; D006373:Helminthiasis / Q000188:drug therapy*; D006376:Helminths / Q000187:drug effects*; D009348:Nematoda / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects; D014200:Trematoda / Q000187:drug effects
D000871:Anthelmintics