A case of facio-scapulo-humero-peroneal myopathy with inflammatory changes. Preliminary data on distribution of mononuclear cells in muscle tissue.
We report the case of a 49 year old woman with clinical, electrophysiological and histochemical signs of facio-scapulohumeroperoneal dystrophy characterized by highly inflammatory changes. Lymphocyte typing by immunofluorescence and immunoperoxidase techniques on a muscle biopsy fragment revealed a large number of T8 cells at endomysial sites. There was no evidence of direct invasion of sound fibers by lymphocytes, which are thus unlikely to have exerted a primary cytotoxic action on the muscle tissue. Another finding was an increased number of macrophages in both endomysial and perivascular regions. Cell-mediated immunity did not play a significant role in the pathogenesis of our case, unlike other reported cases of polymyositis and facioscapulohumeral dystrophy with inflammatory findings.
Marolda
M
M
Clinica Neurologica, II Facoltà di Medicina, Università di Napoli.
Camporeale
F S
FS
Orsini
A V
AV
Cioffi
M
M
Ricci
M
M
De Mattia
G
G
Buscaino
G A
GA
D001706:Biopsy; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism / Q000473:pathology*; D009220:Myositis / Q000209:etiology / Q000473:pathology; D009468:Neuromuscular Diseases / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use
D011241:Prednisone