The influence of adjuvants on the generation of autoantibody and specific suppression in rat erythrocyte-immunized mice.
A number of adjuvants were investigated for their ability to modulate either the autoimmune response induced in mice by immunization with rat erythrocytes (RRBC) or the ability of RRBC-primed spleen cells to suppress the induction of anti-red cell autoimmunity in recipient mice. The inability of the agents used to do so is discussed on the background of models used to explain the generation of suppression in this system.
Elliott
J I
JI
Department of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, UK.
Hutchings
P
P
Malkovsky
M
M
Cooke
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001886:Bordetella pertussis / Q000276:immunology; D003298:Coombs Test; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D005620:Freund's Adjuvant / Q000276:immunology; D007165:Immunosuppression Therapy / Q000379:methods*; D007371:Interferon-gamma / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D007376:Interleukin-2; D007371:Interferon-gamma; D005620:Freund's Adjuvant