Influence of dexamethasone on the RM 3/1-positive macrophages in the peripheral blood and tissues of a New World monkey (the marmoset Callithrix jacchus).
Subcutaneous injection of the glucocorticoid dexamethasone in the primate Callithrix jacchus increased the proportion of the macrophage subtype RM 3/1 in the blood from a basic level of 16% positive monocytes to about 65%. The elevated numbers of RM 3/1-positive cells were seen 24 and 72 h after application and were independent of the dosages used (50 or 150 micrograms/kg). Oral administration had no effect. CD4-, CD14- and CDw14-antigen expression of monocytes was not influenced by the dexamethasone treatment. In tissues, e.g. spleen, thymus, liver, skin and kidney, RM 3/1-positive macrophages revealed a similar distribution as in human tissues but no differences in glucocorticoid treated to control animals could be observed. These results show that glucocorticoids induce in the monkey Callithrix jacchus a distinct monocyte subtype similarly as in man while other macrophage phenotypes were not influenced.
Zwadlo-Klarwasser
G
G
Institute of Pharmacology, Medical Faculty, RWTH Aachen, FRG.
Neubert
R
R
Stahlmann
R
R
Schmutzler
W
W
D000818:Animals; D015704:CD4 Antigens / Q000032:analysis; D002144:Callithrix; D003907:Dexamethasone / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007668:Kidney / Q000166:cytology; D008099:Liver / Q000166:cytology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D012867:Skin / Q000166:cytology; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D015704:CD4 Antigens; D003907:Dexamethasone