title: Palmitic acid kinetics in fasting, traumatized patients.
abstract: The contribution of free fatty acid oxidation to the elevation in energy expenditure after trauma has not been well characterized. Six control subjects and six traumatized patients were fasted for 48 hours and given a primed continuous infusion of (1-14C)palmitate to measure plasma palmitate and total free fatty acid kinetics. Traumatized patients had greater urinary nitrogen losses (20.8 vs. 9.3 g N per day) and a significantly greater ratio of measured to predicted resting energy expenditure (+36% vs. -6%) compared with controls. Individual and total plasma free fatty acid concentrations were similar for the two groups. The turnover and oxidation of plasma palmitate and total free fatty acids were not changed by multiple trauma. These results demonstrated that plasma free fatty acids and palmitate do not contribute to increased energy expenditure following trauma.
authors.affiliation: Department of Surgery, Medical College of Ohio, Toledo.
authors.forename: R H
authors.initials: RH
authors.lastname: Birkhahn
authors.forename: R J
authors.initials: RJ
authors.lastname: Cardwell
authors.forename: G C
authors.initials: GC
authors.lastname: Birkhahn
authors.forename: K A
authors.initials: KA
authors.lastname: Crist
authors.forename: A M
authors.initials: AM
authors.lastname: Taha
authors.forename: N R
authors.initials: NR
authors.lastname: Thomford
mesh_terms: D000328:Adult; D000368:Aged; D002153:Calorimetry, Indirect; D004734:Energy Metabolism; D005215:Fasting / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D005260:Female; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000378:metabolism*; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000097:blood / Q000493:pharmacokinetics*; D011184:Postoperative Period
chemical_list: D005230:Fatty Acids, Nonesterified; D010169:Palmitic Acids; D019308:Palmitic Acid