title: Demonstration of human motor cortex activation using SPECT.
abstract: Recent advances in single photon emission computed tomography (SPECT) have allowed improved image resolution with lower doses of labelled tracer. Capitalizing on these improvements, the authors have developed a new SPECT protocol for imaging neuronal activation. We outline this technique and describe how it can demonstrate increased human motor cortex activity in normal subjects performing a motor task. The ability to accurately demonstrate neuronal activation with SPECT using this method may have important scientific and clinical implications.
authors.affiliation: Institute of Nuclear Medicine, University College and Middlesex School of Medicine, (UCMSM), London, United Kingdom.
authors.forename: M S
authors.initials: MS
authors.lastname: George
authors.forename: H A
authors.initials: HA
authors.lastname: Ring
authors.forename: D C
authors.initials: DC
authors.lastname: Costa
authors.forename: K
authors.initials: K
authors.lastname: Kouris
authors.forename: P J
authors.initials: PJ
authors.lastname: Ell
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005385:Fingers / Q000294:innervation / Q000502:physiology; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime