title: Transforming growth factor alpha expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma--an immunohistochemical study.
abstract: Using a monoclonal antibody (GF10) and a standard immunohistochemical technique, immuno-expression of transforming growth factor alpha (TGF-alpha) was found consistently within the differentiated compartment of normal adult human gastric mucosa. In 70% of mucosal samples exhibiting intestinal metaplasia there was more or less uniform TGF-alpha immunoreactivity throughout the intestinalized mucosa. Similarly, 60% of cases of dysplasia and 60% of gastric carcinomas showed strong immunoreactivity in most of the cells. However, whereas 93% of intestinal-type cancers showed strong immunoreactivity only 30% of the diffuse type were stained and then only weakly. Transforming growth factor alpha expression is thus a fairly regular feature of several types of differentiated gastric epithelia (normal, metaplastic, dysplastic and intestinal-type carcinoma), while its relative absence may be a factor in the histogenesis of the diffuse type of gastric carcinoma.
authors.affiliation: Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: M M
authors.initials: MM
authors.lastname: Nasim
authors.forename: D M
authors.initials: DM
authors.lastname: Thomas
authors.forename: M R
authors.initials: MR
authors.lastname: Alison
authors.forename: M I
authors.initials: MI
authors.lastname: Filipe
mesh_terms: D005753:Gastric Mucosa / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007422:Intestines / Q000737:chemistry* / Q000473:pathology; D008679:Metaplasia / Q000378:metabolism; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology; D016211:Transforming Growth Factor alpha / Q000032:analysis*
chemical_list: D016211:Transforming Growth Factor alpha