[Fluconazole treatment of cryptococcal meningitis associated with HIV infection. Presentation of 4 cases].
We present four cases of C. neoformans meningitis (CNM) in patients with Human Immunodeficiency Virus (HIV) infection treated with fluconazole p.o. at an initial dose of 400 mg followed by 200 mg/day during a follow up period ranging from 3 to 12 months, and who presented an excellent clinical evolution. When comparing them to our previous cases who were treated with Amphotericin-B in combination with 5-fluorocytosine, a decrease in mean hospital stay (p less than 0.001) and a smaller incidence of secondary effects were observed. Treatment with fluconazole seems to be an effective alternative in treatment of CNM. Future greater studies are needed to confirm this findings.
Roig
P
P
Sección de Enfermedades Infecciosas, Hospital General Universitario deValencia.
Carrasco
R
R
Salavert
M
M
Nieto
A
A
Bernacer
B
B
Rodríguez
M
M
Navarro
V
V
D000284:Administration, Oral; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005437:Flucytosine / Q000008:administration & dosage; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007902:Length of Stay; D008297:Male; D016919:Meningitis, Cryptococcal / Q000188:drug therapy*; D013997:Time Factors
D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine
Tratamiento con fluconazol de la meningitis criptocócica asociada a la infección por VIH. Presentación de cuatro casos.