title: Meningoencephalitis due to penicillin-resistant Streptococcus pneumoniae.
abstract: The case of a 68-year-old man suffering from pneumococcal meningoencephalitis is reported. Antibacterial susceptibility tests revealed a multiply resistant pneumococcal strain. High doses of cefotaxime were necessary to sterilize the cerebrospinal fluid despite the achievement of a satisfactory level of antibiotic in the cerebrospinal fluid with moderate dosage. In France, as well as in many countries, high doses of third-generation cephalosporins such as cefotaxime or ceftriaxone should be administered for the initial therapy of suspected pneumococcal meningitis.
authors.affiliation: Service de Réanimation Polyvalente, Hôpital Saint-Antoine, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Vassal
authors.forename: O
authors.initials: O
authors.lastname: Piot
authors.forename: Z
authors.initials: Z
authors.lastname: Mallat
authors.forename: D
authors.initials: D
authors.lastname: Lesage
authors.forename: B
authors.initials: B
authors.lastname: Guidet
authors.forename: G
authors.initials: G
authors.lastname: Offenstadt
mesh_terms: D000368:Aged; D002439:Cefotaxime / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D002439:Cefotaxime