Pregnancy in sickle cell disease in Bahrain.
OBJECTIVE
To review the maternal and fetal complications in pregnant women with sickle cell disease and to compare their pregnancy outcome with those of controls.


METHODS
A case-control study.


METHODS
Ministry of Health hospitals in Bahrain.


METHODS
147 pregnancies in 140 women with sickle cell disease and 294 controls matched for age and parity.


METHODS
The characteristics of women who had crises, the frequency of the crises, hypertensive disorders of pregnancy, infection, diabetes, perinatal mortality and the delivery statistics in the index and control women.


RESULTS
Maternal mortality was 1.4% and perinatal mortality was 73.3/1000 total births in women with sickle cell disease, there were no maternal deaths and the perinatal mortality was 6.8/1000 births in the control group. Anaemia was treated by blood transfusion in 47% of women with sickle cell disease and, of these, 39% had a crisis that appeared to have been precipitated by the transfusion in the absence of any other predisposing factors. The presence of raised HbF did not decrease the number of crises but reduced their severity.


CONCLUSIONS
Pregnancy in women with sickle cell disease should be monitored very closely as it constitutes a high risk to both the mother and the baby.
el-Shafei
A M
AM
Department of Obstetrics & Gynaecology, Salmaniya Medical Centre, Arabian Gulf University, State of Bahrain.
Dhaliwal
J K
JK
Sandhu
A K
AK
D000328:Adult; D000740:Anemia / Q000150:complications; D001424:Bacterial Infections / Q000150:complications; D001445:Bahrain / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007226:Infant Mortality; D007231:Infant, Newborn; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012805:Sickle Cell Trait / Q000453:epidemiology*