[The regional cerebral circulation in infarct patients. Rapid dynamic T2*-weighted MRT after a bolus injection of gadolinium-DTPA].
The aim was to validate the MRI assessment of regional cerebral blood flow. Measurements were performed on a 1.5 T imaging system using a fast T2*-weighted gradient-echo sequence. After intravenous injection of gadolinium-DTPA 30 images were acquired in the same slice position during 84 seconds. In 12 volunteers we observed a symmetrical cortical decrease of signal intensity during the passage of the contrast medium. In 9/23 patients with impairment of cerebral blood flow a circumscribed area of reduced signal intensity decrease (hypoperfusion) was found. In 4/23 patients the decrease of signal intensity was more pronounced than in normals (hyperfusion). In 9/23 patients signal intensity changes were normal. HMPAO-SPECT confirmed successful MRI assessment of cerebral blood flow in 22/23 patients.
Böck
J C
JC
Strahlenklinik und Poliklinik, Universitätsklinikum Rudolf Virchow, Freie Unversität, Berlin.
Sander
B
B
Hierholzer
J
J
Cordes
M
M
Haustein
J
J
Schörner
W
W
Felix
R
R
D002544:Cerebral Infarction / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000008:administration & dosage; D005682:Gadolinium / Q000008:administration & dosage; D019786:Gadolinium DTPA; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009942:Organometallic Compounds / Q000008:administration & dosage; D015609:Organotechnetium Compounds / Q000008:administration & dosage; D010091:Oximes / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage; D011446:Prospective Studies; D012016:Reference Values; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D003287:Contrast Media; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA
Regionale Gehirndurchblutung bei Infarktpatienten. Schnelle dynamische T2*-gewichtete MRT nach Gadolinium-DTPA-Bolusinjektion.