title: Interleukin-1 beta increases synaptic inhibition in rat hippocampal pyramidal neurons in vitro.
abstract: Interleukin-1 (IL-1), a cytokine with a broad spectrum of biological activity, modulates electrical properties of central neurons in the brain. The effects of IL-1 beta (143 pM) on conductances opened by synaptic stimulation of the Schaffer collaterals were studied by intracellular recording of hippocampal pyramidal cells of the CA1 region. IL-1 beta enhanced and prolonged synaptic inhibition by about 2 to 3-fold. Heat-inactivated IL-1 beta had no effect. This finding implies that IL-1 beta changes interneuronal communication in the hippocampus with a possible impact on neuronal plasticity.
authors.affiliation: Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA.
authors.forename: M L
authors.initials: ML
authors.lastname: Zeise
authors.forename: S
authors.initials: S
authors.lastname: Madamba
authors.forename: G R
authors.initials: GR
authors.lastname: Siggins
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D051381:Rats; D013569:Synapses / Q000187:drug effects
chemical_list: D007375:Interleukin-1