title: Animal model for ischemic facial nerve paralysis with selective vascular embolization.
abstract: An experimental model that reliably and easily produces acute ischemic facial nerve paralysis would be useful for the controlled study of treatment and to improve our understanding of the pathophysiology and treatment of facial nerve palsy. Most documented models that simulate clinical facial nerve palsy cause direct damage to the nerve. We describe an experimental model for ischemic facial nerve paralysis in the cat that employs arterial block of the internal and external maxillary and posterior auricular arteries using embolizing material (Avitene). All animals develop stable acute ischemic facial nerve palsy lasting for approximately 2 months. Electromyographic study of this model revealed that the site of the lesion resulting from selective embolization may be within the temporal bone. This model has the advantages of simplicity of technique, cost-effective use of cats, and reproducibility of facial nerve palsy.
authors.affiliation: Department of Otolaryngology, Hyogo College of Medicine, Nishinomiya, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kumoi
authors.forename: H
authors.initials: H
authors.lastname: Iritani
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Minatogawa
mesh_terms: D000818:Animals; D001767:Blinking / Q000502:physiology; D002415:Cats; D003094:Collagen; D004195:Disease Models, Animal; D004576:Electromyography; D004617:Embolism / Q000150:complications*; D005154:Facial Nerve / Q000098:blood supply* / Q000473:pathology; D005158:Facial Paralysis / Q000209:etiology*; D005260:Female; D007511:Ischemia / Q000150:complications*; D008297:Male; D009407:Nerve Block / Q000379:methods; D009410:Nerve Degeneration / Q000502:physiology; D013701:Temporal Bone / Q000473:pathology
chemical_list: D003094:Collagen