title: Dose-responsive effect of radiotherapy on the tumor uptake of L-[methyl-11C]methionine; feasibility for monitoring recurrence of tumor.
abstract: The L-[methyl-11C]methionine [( 11C]Met) uptake by rat AH109A tumor was decreased irradiation-dose dependently from the control to 5, 10 and 20 Gy. After 10 Gy irradiation, the [11C]Met uptake decreased earlier than the tumor volume reduction, and later, it significantly increased earlier than the recurrent growth. Double tracer autoradiography with [14C]Met and 4-[18F]fluoroantipyrine showed a decrease in the [14C]Met tumor uptake without change of blood flow after irradiation. The [11C]Met uptake representing amino acid metabolism is a sensitive indicator for monitoring radiotherapeutic effect on tumor.
authors.affiliation: Department of Radiology, Tohoku University, Sendai, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kubota
authors.forename: K
authors.initials: K
authors.lastname: Ishiwata
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: R
authors.initials: R
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: J
authors.initials: J
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: M
authors.initials: M
authors.lastname: Tada
mesh_terms: D000818:Animals; D001345:Autoradiography; D004307:Dose-Response Relationship, Radiation; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism* / Q000532:radiotherapy; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D012039:Regional Blood Flow / Q000528:radiation effects
chemical_list: D008715:Methionine; C038344:methionine methyl ester