Measurement of serum haptoglobin as an indicator of the efficacy of malaria intervention trials.
Serum haptoglobin levels were measured by an enzyme-linked immunosorbent assay in Gambian children who participated in 3 malaria intervention trials with untreated or impregnated bed nets. In one study, in which a significant effect on clinical malaria was observed, the mean serum haptoglobin level was significantly higher in the intervention than in the control group. In the other 2 studies, in which no significant protection was observed, mean haptoglobin levels were similar in intervention and control groups. Measurement of serum haptoglobin may provide a useful indirect measure of the effectiveness of malaria control programmes.
Sisay
F
F
Medical Research Council Laboratories, Fajara, Banjul, The Gambia.
Byass
P
P
Snow
R W
RW
Greenwood
B M
BM
Perrin
L H
LH
Yerly
S
S
D001512:Bedding and Linens; D002648:Child; D002675:Child, Preschool; D005260:Female; D005714:Gambia; D006242:Haptoglobins / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007300:Insect Control; D007306:Insecticides; D008288:Malaria / Q000097:blood* / Q000517:prevention & control*; D008297:Male; D026023:Permethrin; D011722:Pyrethrins
D006242:Haptoglobins; D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin