Bile acid and sterol solubilization in 2-hydroxypropyl-beta-cyclodextrin.
The use of 2-hydroxypropyl-beta-cyclodextrin has made it possible to prepare stable aqueous solutions of cholesterol, 26-hydroxycholesterol, 7 alpha-hydroxycholesterol, and monohydroxy bile acids such as lithocholic and 3 beta-hydroxy-5-cholenoic acids. These solutions are suitable for cell culture studies and for parenteral administration to animals.
De Caprio
J
J
Division of Hepatic Diseases, New York University Medical Center 10016.
Yun
J
J
Javitt
N B
NB
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D001647:Bile Acids and Salts / Q000008:administration & dosage / Q000737:chemistry*; D002478:Cells, Cultured; D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D012996:Solutions; D013261:Sterols / Q000008:administration & dosage / Q000737:chemistry*; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins
D001647:Bile Acids and Salts; D003505:Cyclodextrins; D004337:Drug Carriers; D012996:Solutions; D013261:Sterols; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; C479658:hydroxypropyl-alpha-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin