Elevated levels of paf-acether in blood of patients with type 1 diabetes mellitus.
Infusion of paf-acether (paf, first described as platelet-activating factor) into animals stimulates glycogenolysis and lipolysis and decreases insulin levels. This study reports a 50-fold increase in blood levels of paf in patients with Type 1 insulin-dependent diabetes mellitus without micro or macrovascular complications (1.07 +/- 0.42 ng/ml, n = 10) as compared with healthy volunteers (0.04 +/- 0.02 ng/ml, n = 9). By contrast, paf is not statistically elevated (p greater than 0.05) in patients with Type 2 non-insulin-dependent, diabetes mellitus with lipid abnormalities and micro or macrovascular complications (0.32 +/- 0.18 ng/ml, n = 9). In the three groups same levels of paf precursors and acetylhydrolase activity (the enzyme which inactivates paf) were noted suggesting an increase in paf biosynthesis by Type 1 diabetic patients. Elevated paf levels could perpetuate hyperglycaemia and tend to promote or accentuate micro or macrovascular complications. This study adds another biological difference between Type 1 and Type 2 diabetes.
Nathan
N
N
Département d'Anesthésie, CHU Dupuytren, Limoges, France.
Denizot
Y
Y
Huc
M C
MC
Claverie
C
C
Laubie
B
B
Benveniste
J
J
Arnoux
B
B
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D010972:Platelet Activating Factor / Q000032:analysis*; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D006442:Glycated Hemoglobin; D010743:Phospholipids; D010972:Platelet Activating Factor; D014280:Triglycerides