title: Treatment and results of chronic toxoplasmosis. Analysis of 33 cases.
abstract: Women who grew up in Turkey, where undercooked meat is part of the usual diet, have an increased risk of toxoplasmosis. This study covers treatment and prognosis of 33 cases with chronic toxoplasmosis. The study group was selected among the patients with a history of repeated abortions, recurrent preterm labor, stillbirths and babies with congenital anomaly after all other causative reasons were ruled out. IgG and IgM antibody titers were detected by Sabin-Feldman's dye test and indirect fluorescence antibody test. 33 patients, who had negative IgM and IgG antibody titers above 1/64, were accepted as having chronic toxoplasmosis and were included in our study group. These patients were treated with our pyrimethamine treatment protocol (Dinçer Formula) for 36 days before their pregnancies. IgG antibody titers were repeated in the 8th and the 20th week of pregnancy. With the exception of 7 cases, 24 patients (72.7%) still had IgG antibody titers of more than 1/64 and were given the same treatment protocol in the 8th week of pregnancy. Very early abortions occurred in 2 cases. Of 24 patients, 8 had antibody titers still above 1/64 and were treated with spiramycine. While 28 cases (84.8%) had healthy and living infants, pregnancies of 3 cases are still continuing. No teratogenic effects of pyrimethamine on the fetuses were seen. As a result, we can say that a patient who presents with complaints of repeated abortions, recurrent preterm labor or stillbirth should be investigated for toxoplasmosis during pregnancy; even if the IgG antibody test is normal before pregnancy, she should be treated with the protocol mentioned above before pregnancy and in the 8th week of pregnancy when chronic toxoplasmosis is diagnosed.
authors.affiliation: Department of Obstetrics and Gynecology, Medical School of Ankara University, Turkey.
authors.forename: S D
authors.initials: SD
authors.lastname: Cengir
authors.forename: F
authors.initials: F
authors.lastname: Ortaç
authors.forename: F
authors.initials: F
authors.lastname: Söylemez
mesh_terms: D000022:Abortion, Spontaneous / Q000628:therapy; D005260:Female; D005313:Fetal Death / Q000517:prevention & control; D006801:Humans; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000517:prevention & control; D011739:Pyrimethamine / Q000627:therapeutic use*; D014123:Toxoplasmosis / Q000188:drug therapy* / Q000517:prevention & control; D014421:Turkey
chemical_list: D011739:Pyrimethamine