The cellular and molecular regulation of 1,25(OH)2D3 production.
The synthesis of 1,25(OH)2D3 is a critical control point in the regulation of calcium metabolism, and possibly in the growth and differentiation of a number of cell types. This paper reviews our current understanding of the regulation of this process at the cellular and molecular levels, with the emphasis on the mechanisms of feedback control 1,25(OH)2D3 itself, control of parathyroid hormone, the roles of cyclic AMP dependent protein kinase and protein kinase C, and the interaction between the various intracellular regulators of 1,25(OH)2D3 production.
Henry
H L
HL
Department of Biochemistry, University of California, Riverside 92521.
Dutta
C
C
Cunningham
N
N
Blanchard
R
R
Penny
R
R
Tang
C
C
Marchetto
G
G
Chou
S Y
SY
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000378:metabolism; D000818:Animals; D002112:Calcifediol / Q000378:metabolism*; D002117:Calcitriol / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D010281:Parathyroid Hormone / Q000502:physiology; D011493:Protein Kinase C / Q000378:metabolism
D010281:Parathyroid Hormone; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; D011493:Protein Kinase C; D002117:Calcitriol; D002112:Calcifediol