Analysis of the detrusor smooth muscle action potential.
A method is described to record bladder smooth muscle action potential (AP) data and subsequently in digitized form analyze the constitutive elements of the AP. Manipulation of digitized data can give accurate descriptive information on the AP configuration and kinetics. In the future this type of analysis will hopefully lead to more precise, quantitative information on changes in the smooth muscle AP kinetics with disease states and facilitate a clearer understanding of the pathophysiological processes underlying changes in detrusor contractility.
Karim
O M
OM
James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Seki
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N
Mostwin
J L
JL
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D006168:Guinea Pigs; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D012984:Software; D001743:Urinary Bladder / Q000502:physiology*; D014563:Urodynamics