title: Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.
abstract: An Mr = 524,000 oligomeric protein was isolated from bovine cartilage and designated COMP (Cartilage Oligomeric Matrix Protein). The protein is composed of disulfide-bonded subunits with an apparent Mr of 100,000 each. It is markedly anionic, probably due to its high contents of aspartic acid and glutamic acid, as well as to its substitution with negatively charged carbohydrates. COMP was found in all cartilages analyzed, but could not be detected in other tissues by enzyme-linked immunosorbent assay of guanidine HCl extracts. Within a given cartilage, COMP shows a preferential localization to the territorial matrix surrounding the chondrocytes.
authors.affiliation: Department of Medical and Physiological Chemistry, University of Lund, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Hedbom
authors.forename: P
authors.initials: P
authors.lastname: Antonsson
authors.forename: A
authors.initials: A
authors.lastname: Hjerpe
authors.forename: D
authors.initials: D
authors.lastname: Aeschlimann
authors.forename: M
authors.initials: M
authors.lastname: Paulsson
authors.forename: E
authors.initials: E
authors.lastname: Rosa-Pimentel
authors.forename: Y
authors.initials: Y
authors.lastname: Sommarin
authors.forename: M
authors.initials: M
authors.lastname: Wendel
authors.forename: A
authors.initials: A
authors.lastname: Oldberg
authors.forename: D
authors.initials: D
authors.lastname: Heinegård
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002241:Carbohydrates / Q000032:analysis; D002358:Cartilage, Articular / Q000737:chemistry* / Q000166:cytology; D002417:Cattle; D002499:Centrifugation, Density Gradient; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins / Q000032:analysis / Q000737:chemistry* / Q000302:isolation & purification; D007124:Immunoenzyme Techniques; D046911:Macromolecular Substances; D064235:Matrilin Proteins; D008970:Molecular Weight; D051381:Rats
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D046911:Macromolecular Substances; D064235:Matrilin Proteins