title: A specific sequence of stimulation is required to induce synthesis of the antimicrobial molecule nitric oxide by mouse macrophages.
abstract: Nitric oxide production by macrophages required either simultaneous or sequential exposure to gamma interferon and lipopolysaccharide; exposure to lipopolysaccharide followed by exposure to gamma interferon gave little response. The apparently evanescent nature of the lipopolysaccharide signal, necessitating persistent stimulation, could be essential to down-regulating nitric oxide production after bacteria are cleared in vivo.
authors.affiliation: Wilkinson Laboratory of the Cancer Center, University of Kansas Medical Center, Kansas City 66160.
authors.forename: R B
authors.initials: RB
authors.lastname: Lorsbach
authors.forename: S W
authors.initials: SW
authors.lastname: Russell
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D007371:Interferon-gamma