Adrenal function in adult asthmatics during long-term daily treatment with 800, 1,200, and 1,600 micrograms triamcinolone acetonide. Multicenter study.
A study to assess the effect of the long-term use of triamcinolone acetonide (TA) on adrenal function was conducted with 143 male and female patients with asthma who were randomly assigned to receive 800, 1200, or 1,600 micrograms of TA daily for six months. Adrenal function was assessed prior to treatment and after two weeks and one, three, and six months of TA use. The effect of TA was evaluated by measuring plasma cortisol levels just prior to and 30 min after a bolus IV injection of 0.25 mg cosyntropin. Adrenal suppression was assumed if the plasma concentration of cortisol did not increase by at least 7 micrograms/dl from the prestimulation value, and remained below 18 micrograms/dl 30 min after the cosyntropin injection. Urine collected for 24 h prior to each cosyntropin stimulation was assayed for free cortisol and related metabolites to confirm suppression. Although all treatment regimens caused some reduction in the 24-h excretion of corticosteroid products, none of the mean values was below the normal ranges. The mean data indicate that TA had no significant effect on adrenal function at any dose or at any time for the patients overall. Individually, three patients exhibited some reduction in adrenal function.
Altman
L C
LC
Division of Allergy and Infectious Disease, University of Washington, Seattle.
Findlay
S R
SR
Lopez
M
M
Lukacsko
P
P
Morris
R J
RJ
Pinnas
J L
JL
Ratner
P H
PH
Szefler
S J
SJ
Welch
M J
MJ
D015065:17-Hydroxycorticosteroids / Q000652:urine; D000280:Administration, Inhalation; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D003366:Cosyntropin; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D015065:17-Hydroxycorticosteroids; D003366:Cosyntropin; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone