title: [Chromosomic etiology of male sterility and infertility].
abstract: Recent advances in the knowledge of sexual development have been obtained by studying individuals with dysgenetic gonads and reproductive tract alterations. By using probes Y-ADN in these patients, it was found that a gene of the short arms of Y chromosome, induces testicular differentiation. The way this gene acts is not known, but the observation that there are homologue sequencies in X and Y, suggests the possibility that sexual differentiation depends on genic doses. Other genes like the one that codifies for antigen H-Y, for skeletal maturation, body growth, dental size and spermatogenesis regulation, have been identified in chromosome Y. Findings that have allowed a better understanding of genetic and cytogenetic factor involved in sterility-infertility.
authors.affiliation: Departamento de Genética, Hospital General Centro Médico La Raza, IMSS, D.F.
authors.forename: M E
authors.initials: ME
authors.lastname: Vega Hernández
authors.forename: N
authors.initials: N
authors.lastname: Pedrón Nuevo
authors.forename: M C
authors.initials: MC
authors.lastname: Márquez Orozco
mesh_terms: D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D012733:Sex Differentiation; D013091:Spermatogenesis; D014998:Y Chromosome
vernacular_title: Etiología cromosómica de la esterilidad e infertilidad masculina.