title: Recent advances in limb lengthening. Part II: Biological advances.
abstract: The most important recent advance in limb lengthening is the recognition that bone will regenerate, under appropriate conditions, within the gap of an osteotomized bone. Although Codivilla recognized this phenomenon, bone formation was inconsistent in his patients. Optimal distraction osteogenesis requires a knowledge of osteotomy techniques, length of latency period, rate and frequency of distraction, and mechanical effects of loading.
authors.affiliation: Department of Orthopedic Surgery, State University of New York, Syracuse.
authors.forename: J T
authors.initials: JT
authors.lastname: Sproul
authors.forename: C T
authors.initials: CT
authors.lastname: Price
mesh_terms: D001852:Bone Lengthening / Q000379:methods*; D001861:Bone Regeneration; D006801:Humans; D024510:Muscle Development; D010012:Osteogenesis / Q000502:physiology*; D010027:Osteotomy / Q000379:methods*; D013710:Tendons / Q000254:growth & development; D016474:Weight-Bearing