Burn-induced gastric mucosal hemodynamic disturbance in the rat. Role of platelet-activating factor.
The role of platelet-activating factor (PAF) as a mediator of gastric damage associated with burn injury was examined in the rat. Gastric mucosal hemodynamics was recorded continuously by means of laser-Doppler flowmetry and reflectance spectrophotometry. Burn injury induced prolonged hypotension and rapid-onset and long-lasting gastric mucosal hemodynamic derangement-that is, ischemia with congestion. This hemodynamic disturbance was significantly inhibited by CV-6209, a specific PAF antagonist. Elevated tissue levels of thiobarbituric acid reactants and pathologic changes in the gastric mucosa subsequent to burn injury were also significantly alleviated by the preadministration of CV-6209. These results strongly suggest a role of PAF as an important mediator of gastric damage after burn injury through its potent vasoactive effect on gastric microcirculation.
Binnaka
T
T
Third Dept. of Internal Medicine, Kansai Medical University, Osaka, Japan.
Yamaguchi
T
T
Kubota
Y
Y
Fujimura
K
K
Tani
K
K
Kitagawa
S
S
Mizuno
T
T
Inoue
K
K
D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001794:Blood Pressure; D002056:Burns / Q000503:physiopathology*; D005753:Gastric Mucosa / Q000098:blood supply / Q000293:injuries / Q000473:pathology / Q000503:physiopathology*; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D010100:Oxygen / Q000378:metabolism; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D011726:Pyridinium Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D013844:Thiazoles / Q000494:pharmacology; D053778:Thiazolidines; D014230:Triazoles / Q000494:pharmacology
D001381:Azepines; D006454:Hemoglobins; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; D013844:Thiazoles; D053778:Thiazolidines; D014230:Triazoles; C053321:CV 6209; C052518:WEB 2086; C065776:3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one; D010100:Oxygen