Monoclonal large granular lymphocyte proliferation in SLE with HTLV-I seroreactivity.
A 60-year-old part Aboriginal woman was observed to develop severe neutropenia and a large granular lymphocyte (LGL) proliferation five years after the diagnosis of systemic lupus erythematosus (SLE). Monoclonality of the CD3+, CD4-, CD8+ LGL population was confirmed using the novel approach of X-linked restriction fragment length polymorphism (RFLP) analysis. Indeterminate HTLV-I serology was present. The patient responded to steroid therapy. LGL proliferation in the setting of SLE and the use of X-linked RFLP analysis to define LGL clonality have not previously been reported.
Marlton
P
P
Mater Misericordiae Hospitals, Brisbane, Qld., Australia.
Taylor
K
K
Elliott
S
S
McCormack
J
J
D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008875:Middle Aged
D000911:Antibodies, Monoclonal