title: Accessory protein function in the DNA polymerase III holoenzyme from E. coli.
abstract: DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.
authors.affiliation: Howard Hughes Medical Institute, Microbiology Department, Cornell University Medical College, NY 10021.
authors.forename: M
authors.initials: M
authors.lastname: O'Donnell
mesh_terms: D004258:DNA Polymerase III / Q000737:chemistry*; D004926:Escherichia coli / Q000201:enzymology*; D008954:Models, Biological
chemical_list: D004258:DNA Polymerase III