title: Successful treatment of systemic Exophiala dermatitidis infection in a patient with chronic granulomatous disease.
abstract: Exophiala dermatitidis, one of the saprophytic dematiaceous fungi, is a rare cause of human infection that, when invasive, is nearly always fatal. Besides the more common subcutaneous infection usually caused by traumatic inoculation, infection can also spread hematogenously, in which case the organism has a distinct neurotropism. A patient with autosomal recessive chronic granulomatous disease of childhood who was found to have a progressive pulmonary and central nervous system infection with E. dermatitidis responded to an aggressive, multifaceted therapeutic approach. Scanning electron microscopy of the cultured conidiogenous cells confirmed that the manner of conidiogenesis is typical of the genus Exophiala. We report the first successful treatment of an infection involving the lungs and central nervous system by a combination of surgical resection of the pulmonary source and medical therapy with amphotericin B, flucytosine or ketoconazole, and transfused white cells, followed by a prolonged course of fluconazole.
authors.affiliation: Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: R T
authors.initials: RT
authors.lastname: Kenney
authors.forename: K J
authors.initials: KJ
authors.lastname: Kwon-Chung
authors.forename: A T
authors.initials: AT
authors.lastname: Waytes
authors.forename: D A
authors.initials: DA
authors.lastname: Melnick
authors.forename: H I
authors.initials: HI
authors.lastname: Pass
authors.forename: M J
authors.initials: MJ
authors.lastname: Merino
authors.forename: J I
authors.initials: JI
authors.lastname: Gallin
mesh_terms: D000328:Adult; D001922:Brain Abscess / Q000188:drug therapy* / Q000209:etiology; D003131:Combined Modality Therapy; D005093:Exophiala / Q000302:isolation & purification* / Q000648:ultrastructure; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D017708:Leukocyte Transfusion; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008855:Microscopy, Electron, Scanning; D009181:Mycoses / Q000209:etiology / Q000628:therapy*; D011859:Radiography