title: [Tropical sprue revealed by severe anemia in a woman from Guadeloupe].
abstract: The case of a young woman from Guadeloupe developing severe megaloblastic anemia is reported. She presented with fever and hemolysis (she had heterozygotic beta-thalassemia) after a six month history of diarrhea. She was shown to have folate deficiency, steatorrhea, vitamin K and B12 malabsorption. She responded well to intravenous folinic acid and tetracyclines. Diagnosis was based on the following criteria: a) no other cause of malabsorption was found despite a comprehensive inquiry, b) the pattern of the illness corresponded to the definition of disease. Three particular aspects are outlined: the acute onset, malabsorption of vitamin B12 requiring prolonged and combined treatment, and the unusual place in which the disease was contracted.
authors.affiliation: Unité de Gastroentérologie, Centre Hospitalier Intercommunal, Poissy.
authors.forename: Y
authors.initials: Y
authors.lastname: Hutin
authors.forename: C
authors.initials: C
authors.lastname: Eugène
mesh_terms: D000328:Adult; D000749:Anemia, Megaloblastic / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D005492:Folic Acid / Q000097:blood / Q000627:therapeutic use; D005494:Folic Acid Deficiency / Q000097:blood / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007263:Infusions, Parenteral; D013182:Sprue, Tropical / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013752:Tetracycline / Q000627:therapeutic use; D013789:Thalassemia / Q000150:complications; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000150:complications / Q000188:drug therapy; D014813:Vitamin K Deficiency / Q000097:blood / Q000150:complications / Q000188:drug therapy; D014900:West Indies
chemical_list: D005492:Folic Acid; D013752:Tetracycline; D014805:Vitamin B 12
vernacular_title: Sprue tropicale révélée par une anémie sévère chez une femme d'origine guadeloupéenne.