Prospective trial on captopril-related cough.
OBJECTIVE
Quantify and characterize cough as an adverse reaction secondary to captopril.


METHODS
Cohort analytic study: six-month prospective trial including two-week, placebo, run-in period; five-month, single-blind, active treatment; and two-week, dechallenge period.


METHODS
Outpatient clinic.


METHODS
199 previously treated or newly diagnosed untreated patients with mild to moderate hypertension.


METHODS
Captopril 50 mg/d during five months.


METHODS
Self-questionnaires, interviews, dechallenge, and rechallenge periods. Naranjo's algorithm.


CONCLUSIONS
(1) Cumulative incidence of captopril-induced cough over a five-month period was 7.1 percent (95 percent C.I., 6.8-7.4 percent). Incidence of drug withdrawal secondary to severe cough was 1.0 percent; this figure is somewhat similar to first reports about the reaction. (2) Cough was a generally mild to moderate symptom, present day and night in 71.4 percent of patients and resistant to antitussive agents. Cough was not statistically related to sex, age, or smoking habit; however, the female gender and the development of a common cold may be predisposing factors.
Lefebvre
J
J
Hypertension Research Unit, Research Center, Centre Hospitalier de l'Université Laval, Ste-Foy, Québec, Canada.
Poirier
L
L
Lacourcière
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002216:Captopril / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016037:Single-Blind Method
D002216:Captopril