Primary B-cell lymphoma with histologic features of a T-cell neoplasm.
A 58-year-old white man had dermatomyositis and primary cutaneous B-cell lymphoma. The cutaneous lymphoma was evidenced by a noduloulcerative disease of the lower extremities. Histologic results resembled a T-cell process with a diffuse, superficial infiltrate composed of small- and medium-sized lymphocytes with angioinvasion and epidermotropism. The infiltrate extended into the deep dermis and panniculus with scattered large lymphocytes and necrosis. With the help of gene-rearrangement analysis and immunophenotyping, the true B-cell lineage was discovered. The importance of gene-rearrangement analysis and immunophenotyping in the diagnosis of cutaneous lymphoma is emphasized.
Landa
N G
NG
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
Zelickson
B D
BD
Kurtin
P J
PJ
Winkelmann
R K
RK
D015139:Blotting, Southern; D003882:Dermatomyositis / Q000150:complications; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D007866:Leg / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*