title: A bacterial binding site which binds human chorionic gonadotropin but not human luteinizing hormone.
abstract: Exposed sites on Pseudomonas maltophilia (ATC #1637), which bind both human chorionic gonadotropin (hCG) and a native hCG-like ligand with equal high affinity, are described. This high-affinity binding site (Kd = 1.3 x 10(-10) binds hCG, but does not bind human luteinizing hormone (hLH), nor related human glycoprotein hormones, thyrotropin, and follicle stimulating hormone. A lower affinity, 2.3 x 10(-9), is also described which binds hLH and hCG equally well. This is the first description of a high-affinity binding site in nature, which distinguishes hCG from hLH.
authors.affiliation: Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132.
authors.forename: D T
authors.initials: DT
authors.lastname: Carrell
authors.forename: W D
authors.initials: WD
authors.lastname: Odell
mesh_terms: D001665:Binding Sites; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism*; D011549:Pseudomonas / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D006063:Chorionic Gonadotropin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin