Is Parkinson's disease a mitochondrial disorder?
Parkinson's disease (PD) is a common degenerative disease, but its etiology is still unknown. However, since the discovery of MPTP, many investigators have been interested in the mitochondrial function in PD. We investigated mitochondrial functions in PD patients using the methods which have successfully been applied to mitochondrial myopathies (MM), i.e. assay of lactate and pyruvate, measurement of muscle mitochondrial respiratory enzyme activities and Southern blot analysis of muscle mitochondrial DNA. Parkinson's disease patients did not differ from controls in the mean blood and CSF (cerebrospinal fluid) lactate and pyruvate levels at the basal resting state or during an aerobic exercise. But mitochondrial complex I activity of the skeletal muscle was significantly decreased in PD. In the Southern blot analysis, we could not find major deletions or insertions of mitochondrial DNA in PD. Our studies disclosed a differential mitochondrial impairment between PD and MM. We discuss the implication of our observation.
Nakagawa-Hattori
Y
Y
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Yoshino
H
H
Kondo
T
T
Mizuno
Y
Y
Horai
S
S
D000332:Aerobiosis; D000368:Aged; D015139:Blotting, Southern; D004272:DNA, Mitochondrial / Q000378:metabolism; D005080:Exercise Test; D006801:Humans; D007773:Lactates / Q000097:blood / Q000134:cerebrospinal fluid; D019344:Lactic Acid; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D010300:Parkinson Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D011773:Pyruvates / Q000097:blood / Q000134:cerebrospinal fluid; D019289:Pyruvic Acid
D004272:DNA, Mitochondrial; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid