Balance of prostacyclin and thromboxane in offspring of parents with premature coronary arterial disease.
6-keto-prostaglandin F1a and thromboxane B2 were determined in order to obtain more information about the prostacyclin synthesis and thromboxane A2 release in 3- to 18-year-old healthy children and in offspring of parents who have had an acute myocardial infarction before the age of 45. The authors demonstrated a reduction of plasma prostacyclin synthesis in children with a positive family history of premature coronary arterial disease. Thromboxane levels in the affected adolescent boys were significantly lower compared with the controls. The ratio of thromboxane:prostacyclin in endangered children did not show a significant difference from that of healthy controls. These data indicate that prostaglandins are a definitive marker for identifying cardiovascular risk children. It must be supposed that in adolescence, only in boys, with a positive family history of premature coronary arterial disease, a compensatory mechanism exists to protect them from developing an imbalance in the regulation of prostaglandins.
Mihai
K
K
Department of Paediatrics, County Hospital, Kecskemét, Hungary.
Petö
J
J
Kolthay
E
E
Makáry
A
A
Timár
S
S
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood*; D000293:Adolescent; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D012307:Risk Factors; D013929:Thromboxane B2 / Q000097:blood*
D015415:Biomarkers; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol