Blood pressure changes modify the release rates of catecholamines in the intermediate nucleus of the solitary tract.
In anaesthetized cats, the intermediate aspect of the nucleus of the solitary tract (NTS) was bilaterally superfused with artificial CSF through push-pull cannulae. The release of the endogenous catecholamines dopamine, noradrenaline and adrenaline was determined in the superfusates radioenzymatically. Blood pressure changes were elicited by intravenous injections of drugs (noradrenaline or chlorisondamine), or electrical stimulation of the intermediate NTS with the tip of the push-pull cannula. Intravenous injections of noradrenaline (3 or 10 micrograms/kg) elicited a rise in the arterial blood pressure which was associated with a decrease in the release rate of adrenaline in the intermediate NTS. The release rates of dopamine and noradrenaline were not influenced. The intravenous injection of chlorisondamine (3 mg/kg) lowered blood pressure and diminished the release rate of dopamine in the intermediate NTS. The release rate of noradrenaline was not modified by chlorisondamine. Electrical stimulation of the intermediate NTS contralateral to the superfused nucleus increased moderately the arterial blood pressure and decreased the release rate of noradrenaline and dopamine, while the release of adrenaline was not influenced. The findings suggest that experimentally induced changes in the arterial blood pressure by drugs injected intravenously modify the release rates of adrenaline and dopamine in the intermediate NTS so as to counteract the blood pressure change. In the intermediate NTS, release of adrenaline from adrenergic nerve terminals seems to act hypertensive. The results obtained with chlorisondamine point to a hypotensive function of endogenous dopamine in the intermediate NTS.
Singewald
N
N
Institut für Pharmakodynamik und Toxikologie, Universität Innsbruck, Austria.
Klausmair
A
A
Philippu
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D002714:Chlorisondamine / Q000008:administration & dosage / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism*; D009638:Norepinephrine / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology
D002714:Chlorisondamine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine