title: Serum androstanediol glucuronide in women with facial hirsutism.
abstract: BACKGROUND
  Measurement of serum 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (3 alpha-diolG) has been proposed as a useful biochemical marker of peripheral androgen metabolism. Is 3 alpha-diol G a useful biochemical marker of peripheral androgen metabolism and does it correlate with degree of facial hirsutism?
  
  
  OBJECTIVE
  Our purpose was to assess possible correlation between serum 3 alpha-diol G and degree of facial hirsutism and to compare serum 3 alpha-diol G levels with levels of other commonly measured serum androgens.
  
  
  METHODS
  Twenty-three consecutive women with facial hirsutism were studied, and serum concentrations of 3 alpha-diol G, testosterone (total, free, and biologically active portions), dehydroepiandrosterone sulfate, and androstenedione were measured.
  
  
  RESULTS
  There was no correlation between serum 3 alpha-diol G levels and degree of facial hirsutism. There was a correlation between levels of 3 alpha-diol G and dehydroepiandrosterone sulfate (p less than 0.01), biologically active testosterone (p = 0.01), free free testosterone (p less than 0.02), and androstenedione (p less than 0.05).
  
  
  CONCLUSIONS
  Serum 3 alpha-diol G concentrations have no correlation with degree of facial hirsutism and do not provide additional information over the commonly measured androgens.
authors.affiliation: Division of Endocrinology, Hahnemann University Hospital, Philadelphia, PA 19102.
authors.forename: K
authors.initials: K
authors.lastname: Salman
authors.forename: R L
authors.initials: RL
authors.lastname: Spielvogel
authors.forename: L H
authors.initials: LH
authors.lastname: Shulman
authors.forename: J L
authors.initials: JL
authors.lastname: Miller
authors.forename: R E
authors.initials: RE
authors.lastname: Vanderlinde
authors.forename: L I
authors.initials: LI
authors.lastname: Rose
mesh_terms: D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005148:Facial Dermatoses / Q000097:blood*; D005260:Female; D006628:Hirsutism / Q000097:blood*; D006801:Humans
chemical_list: D000728:Androgens; D015415:Biomarkers; D015113:Androstane-3,17-diol; C028895:androstane-3,17-diol glucuronide