Cluster headache: oxygen saturation and end-tidal CO2 during and without attack.
Twenty-eight cluster headache patients were examined either in remission (n = 10), in the interparoxysmal period ("cluster phase") (n = 12), or during spontaneously occurring (n = 7), or nitroglycerin provoked (n = 7) attacks. Fourteen healthy controls participated in the study. Oxygen saturation (SaO2), end-tidal CO2 (PCO2), and respiratory rate (R.R.) were recorded for the controls and the patients during the different phases of cluster headache. Both PCO2 and SaO2 tended to be lower during the interparoxysmal period of the cluster phase when compared to the control group or to the remission. During both nitroglycerin-provoked and spontaneous attacks, PCO2 and SaO2 tended to respectively decrease and increase, both when compared with the "cluster phase" and with the period immediately prior to attack ("pre-attack"). Hence the "pre-attack" state may, on an average, be characterized by a slight hypoxia and a slight hyperventilation. Marked, clinically observable hyperventilation was present only in the occasional cluster headache patient. There was no SaO2 decrease from the "cluster phase" (interparoxysmal period) to the period immediately preceding the attack ("pre-attack"), and SaO2 "dips" preceding an attack were only observed in one cluster headache patient. As demonstrated previously by our group, a considerable lowering of SaO2 (i.e. partly to less than or equal to 83%) does only exceptionally lead to attack (Zhao et al, 1990). This observation combined with the evidence presented herein may seem to indicate that the slight pre-attack oxygen desaturation probably is too small to be a symptom-producing factor in cluster headache--be it in the spontaneously occurring or in the induced attack.(ABSTRACT TRUNCATED AT 250 WORDS)
Zhao
J M
JM
Department of Neurology, Regionsykehuset i Trondheim, Trondheim University Hospitals, Norway.
Sand
T
T
Sjaastad
O
O
D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000032:analysis; D003027:Cluster Headache / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000502:physiology*; D013990:Tidal Volume
D002245:Carbon Dioxide; D010100:Oxygen