title: Recurrent Histoplasma capsulatum pneumonia: a case report.
abstract: The epidemiological, clinical and therapeutical findings are described in a case of recurrent pulmonary histoplasmosis due to Histoplasma capsulatum. The patient, a bulldozer-operator, worked in Africa for a long period in extremely dusty conditions without any protection. Three different episodes of H. capsulatum pneumonia recurred during eighteen months after his return from Africa. A full dose treatment by Amphotericin B failed to eliminate disease recurrence on three occasions. The high concentration of airborne H. capsulatum spores inhaled could have been the main cause of the difficulty obtaining a rapid sterilization of the microorganism by Amphotericin B and disease recurrence. The late start of the treatment or the unexplained ability of some persons to develop repeated infections even with normal immunological parameters could be another explanation for the reported phenomenon.
authors.affiliation: Institute of Infectious Diseases, IRCSS-Policlinico S. Matteo, Pavia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tinelli
authors.forename: G
authors.initials: G
authors.lastname: Michelone
authors.forename: C
authors.initials: C
authors.lastname: Cavanna
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D004391:Dust / Q000009:adverse effects*; D006660:Histoplasmosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D009784:Occupational Diseases / Q000188:drug therapy / Q000209:etiology*; D011014:Pneumonia / Q000188:drug therapy / Q000209:etiology*; D012008:Recurrence
chemical_list: D004391:Dust; D000666:Amphotericin B; D007654:Ketoconazole