Comparative study of the prognostic value of nuclear grade and silver-binding nucleolar organizer region in renal cell carcinomas.
Silver-binding nucleolar organizer region (AgNOR) and nuclear grade were histologically assessed in 112 renal cell carcinomas. Nuclear grade was better capable of stratification than AgNOR in terms of survival prediction. It also had prognostic significance when total metastatic rates were evaluated. Although higher mean AgNOR numbers were constantly associated with higher nuclear grades, two arbitrary classifications of AgNOR (less than 1.5, 1.5-3.5, greater than 3.5; less than 2, 2-3, greater than 3) failed to resolve the survival difference.
Yang
A H
AH
Department of Pathology, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Wang
T Y
TY
Liu
H C
HC
D002292:Carcinoma, Renal Cell / Q000473:pathology* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D011379:Prognosis; D016622:Silver Staining / Q000379:methods; D015996:Survival Rate