title: Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride.
abstract: Cellular Mg2+ depletion has been reported in patients on long term diuretic therapy. We therefore measured lymphocyte free Mg2+ concentrations in patients with congestive cardiac failure treated with loop diuretics or a frusemide/amiloride mixture (Frumil) and compared them with control subjects. There was no correlation between lymphocyte free Mg2+ levels and plasma Mg2+ concentrations. Patients treated with loop diuretics did not show lymphocyte intracellular free Mg2+ depletion compared with normal controls, and those on Frumil showed higher intracellular free Mg2+ levels than normal.
authors.affiliation: Department of Pharmacology & Therapeutics, Leicester Royal Infirmary.
authors.forename: L L
authors.initials: LL
authors.lastname: Ng
authors.forename: M C
authors.initials: MC
authors.lastname: Garrido
authors.forename: J E
authors.initials: JE
authors.lastname: Davies
authors.forename: M J
authors.initials: MJ
authors.lastname: Brochwicz-Lewinski
authors.forename: L B
authors.initials: LB
authors.lastname: Tan
mesh_terms: D000584:Amiloride / Q000627:therapeutic use*; D002034:Bumetanide / Q000627:therapeutic use*; D002413:Cations, Divalent; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008274:Magnesium / Q000097:blood*; D013050:Spectrometry, Fluorescence
chemical_list: D002413:Cations, Divalent; D002034:Bumetanide; D000584:Amiloride; D005665:Furosemide; D008274:Magnesium