Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis.
Plasma tumour necrosis factor-alpha (TNF-alpha) was measured in 15 children with atopic dermatitis, 13 children with bronchial asthma, and 11 healthy controls. Plasma TNF-alpha concentration was increased in atopic dermatitis and the magnitude of the increase was correlated with the severity of the dermatitis but TNF-alpha concentration was not increased in bronchial asthma. A significant correlation was found between plasma TNF-alpha and plasma histamine concentrations in atopic dermatitis. The data suggest that the overproduction of TNF-alpha is associated with increased plasma histamine concentration, and might play a part in the pathophysiological mechanism of atopic dermatitis.
Sumimoto
S
S
Department of Paediatrics, Sumitomo Hospital, Osaka, Japan.
Kawai
M
M
Kasajima
Y
Y
Hamamoto
T
T
D000293:Adolescent; D001249:Asthma / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood*; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D007223:Infant; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D014409:Tumor Necrosis Factor-alpha; D006632:Histamine