Neutralization of the effects of captopril by the use of ibuprofen in an elderly woman.
This case report demonstrates that the antihypertensive effects of captopril were neutralized by the concomitant administration of ibuprofen. If elderly patients on ACE inhibitors show evidence of a "noncompliant" worsening of their hypertension, a thorough review of all the patient's medications, including the use of over-the-counter ibuprofen, should be undertaken.
Espino
D V
DV
Department of Family Practice, University of Texas Health Science Center, San Antonio 78284-7795.
Lancaster
M C
MC
D000368:Aged; D002216:Captopril / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010003:Osteoarthritis / Q000188:drug therapy; D013467:Sulindac / Q000008:administration & dosage / Q000627:therapeutic use
D013467:Sulindac; D002216:Captopril; D007052:Ibuprofen