title: BIOSITE: a program for the interactive comparison of aligned homologous protein sequences.
abstract: A program, BIOSITE, providing for the interactive visual comparison of aligned homologous amino-acid sequences is presented, including an example of its application. The program allows for two types of comparison sequence to be generated: an 'identity' sequence and a 'difference' sequence. These may be used on subsets of sequences and in further comparisons to identify candidate sites involved in a distinct functional property. The program should prove a useful tool for biologists engaged in understanding sequence--function relationships.
authors.affiliation: Molecular Graphics Unit, Bath University, UK.
authors.forename: V B
authors.initials: VB
authors.lastname: Cockcroft
authors.forename: J T
authors.initials: JT
authors.lastname: Pedersen
authors.forename: G G
authors.initials: GG
authors.lastname: Lunt
authors.forename: D J
authors.initials: DJ
authors.lastname: Osguthorpe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics*; D011978:Receptors, Nicotinic / Q000235:genetics / Q000276:immunology; D016415:Sequence Alignment / Q000706:statistics & numerical data*; D012984:Software
chemical_list: D011506:Proteins; D011978:Receptors, Nicotinic