The deleterious effect of macrophage colony-stimulating factor (CSF-1) on the pathology of experimental candidiasis in mice.
Mice infected with Candida albicans albicans intravenously were treated before or after infection with macrophage colony-stimulating factor (CSF-1) to elevate their circulating monocyte and tissue macrophage counts. Both treatments exacerbated the disease, causing a doubling of the rate of weight loss and leading to significantly earlier death. The results suggest that macrophages play a major role in the pathology of the disease.
Hume
D A
DA
M.D. Anderson Cancer Center, Department of Cell Biology, Houston, TX 77030.
Denkins
Y
Y
D000818:Animals; D002177:Candidiasis / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D011994:Recombinant Proteins / Q000494:pharmacology; D015431:Weight Loss / Q000187:drug effects
D011994:Recombinant Proteins; D016173:Macrophage Colony-Stimulating Factor