Lipoprotein profile of children with asthma receiving long-term theophylline therapy: a preliminary study.
Lipid profiles were determined in three groups of children: children with asthma receiving long-term therapy with slow-releasing theophylline, children with asthma not treated with theophylline, and a control group of children without asthma. Total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A levels and the high-density lipoprotein/low-density lipoprotein ratio were significantly higher among theophylline-treated children. The observed changes do not seem to increase the risks of atherosclerotic coronary artery disease.
Yagupsky
P
P
Department of Pediatrics, Soroka Medical Center, Ben Gurion University of Negev, Beer-Sheva, Israel.
Shahak
E
E
Tal
A
A
Bearman
J E
JE
Zuili
I
I
Shany
S
S
D001053:Apolipoproteins / Q000097:blood; D001249:Asthma / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003324:Coronary Artery Disease / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000187:drug effects; D008297:Male; D012307:Risk Factors; D013806:Theophylline / Q000627:therapeutic use*; D013997:Time Factors
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D003692:Delayed-Action Preparations; D008074:Lipoproteins; D002784:Cholesterol; D013806:Theophylline