[The interaction of lipoic acid and its metabolites with aspartate and alanine aminotransferases in a multienzyme complex from rat liver and brain mitochondria].
It is shown that lipoic acid and its metabolites--lipoamide and 4,6-dithiohexanoic acid can interact and inhibit the mitochondrial aspartate- and alanine-aminotransferase activities. This effect is much more pronounced in the case of multienzyme complexes--metabolon.
Fan
V T
VT
Petrov
S A
SA
Rozanov
A Ia
AIa
D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000187:drug effects*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004347:Drug Interactions; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*
D009097:Multienzyme Complexes; C015716:bisnorlipoate; D008063:Thioctic Acid; C013091:lipoamide; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase
Vzaiemodiia lipoievoï kysloty ta ïï metabolitiv z aspartat- i alaninaminotransferazoiu u mul'tienzymnomu kompleksi mitokhondriĭ pechinky i mozku shchuriv.