The vegetalizing factor. A member of the evolutionarily highly conserved activin family.
The mesoderm and endoderm inducing vegetalizing factor was partially sequenced after BrCN cleavage. A sequence which is highly conserved in activin A near the C-terminal end was identified. This shows that the factor belongs to the activin family. The activins are not confined to embryos and gonads, but widely distributed in other tissues like calf kidney and calf liver. Functional aspects are discussed.
Tiedemann
H
H
Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Germany.
Lottspeich
F
F
Davids
M
M
Knöchel
S
S
Hoppe
P
P
Tiedemann
H
H
D028341:Activins; D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D002417:Cattle; D002642:Chick Embryo; D007265:Inhibins / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification / Q000494:pharmacology; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008969:Molecular Sequence Data; D014319:Triturus; D014982:Xenopus laevis
D028341:Activins; D007265:Inhibins