Sleep and wakefulness after treatment for craniopharyngioma in childhood; influence on the quality and maturation of sleep.
Craniopharyngiomas are situated in immediate vicinity of sleep regulating structures in the basal forebrain area, and the tumor and its treatment might influence the regulation of sleep and wakefulness. In 10 patients treated for craniopharyngioma nighttime sleep quality and daytime vigilance were examined with polygraphic sleep records and multiple sleep latency tests (MSLT). Two girls and 8 boys, 7.1-22.9 years of age, were studied after a follow-up time of 1.5-16.1 years postoperatively. The results were compared to those of 18 normal children. The regulation of the ultradian sleep rhythm was normal but the ability to maintain nighttime sleep was severely disturbed. The patients had an increased number of awakenings and spent long time awake during two recorded nights. Two patients had excessive daytime somnolence during this examination, one after severe sleep disturbance, the other without any known cause. The pattern of sleep and vigilance did not change in puberty in the expected fashion. The disturbances may well have an impact on the psychosocial situation of the patients.
Palm
L
L
Department of Pediatrics, University Hospital, Lund, Sweden.
Nordin
V
V
Elmqvist
D
D
Blennow
G
G
Persson
E
E
Westgren
U
U
D000293:Adolescent; D000328:Adult; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology*; D003397:Craniopharyngioma / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009460:Neurologic Examination; D010902:Pituitary Gland / Q000503:physiopathology; D010911:Pituitary Neoplasms / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000503:physiopathology*; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology; D014851:Wakefulness / Q000502:physiology*