A new tetracycline antibiotic with antitumor activity. I. Taxonomy and fermentation of the producing strain, isolation and characterization of SF2575.
A new antitumor antibiotic SF2575 has been isolated from a culture filtrate of Streptomyces sp. SF2575. The molecular formula was determined to be C40H43NO15 by elemental analysis, mass and 13C NMR spectral analyses. The spectral data revealed SF2575 to be a new tetracycline antibiotic. It was active against Gram-positive bacteria and exhibited antitumor activity against P388 leukemia in mice.
Hatsu
M
M
Pharmaceutical Research Center, Meiji Seika Kaish, Ltd., Yokohama, Japan.
Sasaki
T
T
Watabe
H
H
Miyadoh
S
S
Nagasawa
M
M
Shomura
T
T
Sezaki
M
M
Inouye
S
S
Kondo
S
S
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013302:Streptomyces / Q000145:classification* / Q000378:metabolism; D013754:Tetracyclines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D013754:Tetracyclines; C074360:SF 2575