title: Effect of estradiol and ethynylestradiol on microtubule distribution in Chinese hamster V79 cells.
abstract: The effects of estradiol (E2) and ethynylestradiol (EE2) on the chromosome number and cellular microtubule architecture of Chinese hamster V79 cells were studied using fluorescent anti-tubulin antibody. Treatment with 20 microM E2 for 48 h induced only a small amount of tetraploid cells, but the normal microtubule network was disrupted completely by only 3 h of treatment. This data reveals that E2 has higher microtubule-disruptive activity than diethylstilbestrol in V79 cells.
authors.affiliation: Kyoritsu College of Pharmacy, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakibara
authors.forename: T
authors.initials: T
authors.lastname: Oda
authors.forename: E
authors.initials: E
authors.lastname: Aizu-Yokota
authors.forename: K
authors.initials: K
authors.lastname: Ichinoseki
mesh_terms: D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004958:Estradiol / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D008870:Microtubules / Q000187:drug effects*
chemical_list: D004997:Ethinyl Estradiol; D004958:Estradiol