Symptomatic and prophylactic treatment of migraine and tension-type headache.
Pharmacotherapy is the mainstay for patients with persistent headaches. When simple analgesics can no longer be used, combination analgesics are prescribed. Symptomatic medications also include antiemetics, ergot derivatives, corticosteroids, neuroleptics, and narcotics. Nonsteroidal anti-inflammatory drugs are commonly used both symptomatically and prophylactically, and are the treatment of choice for menstrual migraine. Exertional migraine, benign orgasmic cephalalgia, chronic paroxysmal hemicrania, cough headache, and "ice-pick" headache are treated with indomethacin. Ergotamine tartrate is often recommended when simple or combination analgesics do not relieve headaches. Dihydroergotamine (DHE) is effective for treating intractable headache; because it has fewer side effects than ergotamine, it is tolerated by patients unable to tolerate other ergotamine preparations. DHE is administered IM and, for occasional use, patients can be taught self-injection. Repetitive IV DHE therapy for chronic severe headaches requires hospitalization; most patients become headache-free within 3 days. Patients who refuse hospitalization, do not respond to the drug, or are not suitable candidates for DHE therapy may receive a short course of a corticosteroid, a neuroleptic or, rarely, a narcotic. For frequent headaches, prophylactic treatment usually begins with a tricyclic antidepressant or a beta blocker.
Schulman
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EA
Temple University School of Medicine, Philadelphia, Pennsylvania.
Silberstein
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SD
D000700:Analgesics / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D004087:Dihydroergotamine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004876:Ergot Alkaloids / Q000627:therapeutic use; D006261:Headache / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000517:prevention & control
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004876:Ergot Alkaloids; D004087:Dihydroergotamine