Influence of three-day antimicrobial therapy and lactobacillus vaginal suppositories on recurrence of urinary tract infections.
Forty-one adult women with acute lower urinary tract infections (UTI) were randomly treated for three days with norfloxacin or trimethoprim/sulfamethoxazole (TMP/SMX). Infection was eradicated in 100% of norfloxacin-treated patients and in 95% of TMP/SMX-treated patients. UTI recurred in 29% of patients treated with norfloxacin and in 41% of those treated with TMP/SMX. Post-therapy vaginal administration of lactobacillus suppositories resulted in a recurrence rate of UTI of only 21%, while in patients given sterilized skim-milk suppositories the recurrence rate was 47%. This study indicates that lactobacillus vaginal suppositories are safe and may be effective in reducing the recurrence of UTI following antimicrobial therapy.
Reid
G
G
Department of Microbiology and Immunology, University of Western Ontario, London, Canada.
Bruce
A W
AW
Taylor
M
M
D000328:Adult; D004755:Enterobacteriaceae; D004756:Enterobacteriaceae Infections / Q000188:drug therapy*; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D007709:Klebsiella; D007710:Klebsiella Infections / Q000188:drug therapy; D007778:Lactobacillus; D009643:Norfloxacin / Q000627:therapeutic use; D010570:Pessaries; D011511:Proteus; D011512:Proteus Infections / Q000188:drug therapy; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D009643:Norfloxacin