Uses and limitations of positron emission tomography in clinical pharmacokinetics/dynamics (Part I).
Positron emission tomography (PET) involves imaging the biodistribution and tissue localisation of small amounts of radiolabelled biomolecules or drugs. In Part I of this article, the applications of pharmacokinetics in PET are discussed in order to derive quantitative measures of physiological function. Part II will examine the use of PET imaging as a tool to study the pharmacokinetics and pharmacodynamics of specific drugs.
Ponto
L L
LL
Department of Radiology, University of Iowa, Iowa City.
Ponto
J A
JA
D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D014055:Tomography, Emission-Computed / Q000379:methods*