title: Effects of carbon dioxide inhalation on cerebral blood flow and oxygen tissue level in spontaneously hypertensive rabbits.
abstract: OBJECTIVE
  Because previous studies have yielded conflicting results, this study was designed to investigate the efficiency of cerebrovascular reactivity to carbon dioxide in hypertension associated with moderate diffuse cerebral ischemic lesions.
  
  
  METHODS
  The effects of carbon dioxide inhalation on mean arterial blood pressure, heart and respiration rates, cerebral cortical blood flow, polarographically detected oxygen currents (oxygen availability), and cerebral electrical activity were compared in 14 spontaneously hypertensive and 16 normotensive rabbits anesthetized with urethane and alpha-chloralose. Blood flow was measured with the hydrogen clearance and thermal clearance methods.
  
  
  RESULTS
  In the resting state the frequency of electrical activity shifted to slower components, the levels of oxygen availability and cerebral blood flow were lower (p less than 0.01), and the ratio of the two latter parameters was greater (p less than 0.01) in hypertensive rabbits than in normotensive animals. Carbon dioxide inhalation induced more marked increases in cerebral blood flow, respiration rate, and oxygen availability in hypertensive (p less than 0.01) than in normotensive (p less than 0.05) rabbits. The ratio of oxygen availability to cerebral blood flow decreased (p less than 0.01) in the former and did not change significantly in the latter group. The carbon dioxide-induced rise in blood flow was also slower and more protracted in hypertensive rabbits (p less than 0.01). Histological investigation revealed groups of neurons with ischemic changes in the cortex of the hypertensive rabbits.
  
  
  CONCLUSIONS
  We suggest that in hypertensive rabbits the mild multiple ischemic lesions are the basis of functional disturbances, including reduced resting cerebral blood flow, greater oxygen tissue level, slower response to carbon dioxide, and greater vasodilatory capacity.
authors.affiliation: Department of Neurology and Psychiatry, University of Debrecen Medical School, Hungary.
authors.forename: K
authors.initials: K
authors.lastname: Hegedüs
authors.forename: I
authors.initials: I
authors.lastname: Fekete
authors.forename: L
authors.initials: L
authors.lastname: Molnár
mesh_terms: D000280:Administration, Inhalation; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000473:pathology; D002245:Carbon Dioxide / Q000008:administration & dosage* / Q000494:pharmacology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004569:Electroencephalography; D005260:Female; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D011817:Rabbits; D012016:Reference Values
chemical_list: D002245:Carbon Dioxide