Meningoencephalitis due to penicillin-resistant Streptococcus pneumoniae.
The case of a 68-year-old man suffering from pneumococcal meningoencephalitis is reported. Antibacterial susceptibility tests revealed a multiply resistant pneumococcal strain. High doses of cefotaxime were necessary to sterilize the cerebrospinal fluid despite the achievement of a satisfactory level of antibiotic in the cerebrospinal fluid with moderate dosage. In France, as well as in many countries, high doses of third-generation cephalosporins such as cefotaxime or ceftriaxone should be administered for the initial therapy of suspected pneumococcal meningitis.
Vassal
T
T
Service de Réanimation Polyvalente, Hôpital Saint-Antoine, Paris, France.
Piot
O
O
Mallat
Z
Z
Lesage
D
D
Guidet
B
B
Offenstadt
G
G
D000368:Aged; D002439:Cefotaxime / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000382:microbiology
D002439:Cefotaxime