Hormonal regulation of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase in rat liver cytosol.
In rat liver, dihydrodiol dehydrogenase and 3 alpha-hydroxysteroid dehydrogenase activities are catalyzed by the same protein. This study shows that estrogen and growth hormone can induce the enzyme in hypophysectomized rats. This implies that estrogen can exert an effect on hepatic steroid and carcinogen metabolism in the absence of the anterior pituitary.
Penning
T M
TM
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104-6084.
Isaacson
K
K
Lyttle
C R
CR
D015096:3-Hydroxysteroid Dehydrogenases / Q000096:biosynthesis*; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); D000367:Age Factors; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D007016:Hypophysectomy; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010052:Ovariectomy; D010088:Oxidoreductases / Q000096:biosynthesis*; D010641:Phenotype; D051381:Rats; D012737:Sex Factors
D004958:Estradiol; D013006:Growth Hormone; D010088:Oxidoreductases; D015096:3-Hydroxysteroid Dehydrogenases; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); C048338:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase