The stereo-, regio-, and chemo-selective conversion of diterpenoids, kamebakaurin to oriaonin.
In this paper, we report the first stereo-, regio-, and chemo-selective conversion of oridonin from kamebakaurin. The overall yield in 7 steps is 9%.
Zhou
W S
WS
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
Cheng
Y X
YX
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D004224:Diterpenes / Q000138:chemical synthesis*; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; C011959:oridonin; C047382:kamebakaurin