Effect of angiotensin II on the endolymphatic sac direct current potential.
The effect of angiotensin II (ANG II), known as a potent pressor hormone, on the endolymphatic sac direct current potential (ESP) was examined. Intravenous administration of ANG II produced a reversible decrease in the ESP at doses exceeding 0.1 microgram/kg. The effect of ANG II on the ESP was dose-dependent at doses of less than 3 micrograms/kg with a saturated effect at doses of more than 3 micrograms/kg. The maximum reduction of the ESP produced by ANG II was 33.8 +/- 2.9% (m +/- SE, n = 6) of the original amplitude. The action of ANG II on the ESP was blocked by propranolol (beta-adrenergic antagonist). The mechanism underlying the action of ANG II on the ESP is discussed.
Mori
N
N
Department of Otolaryngology, Kagawa Medical School, Japan.
Uozumi
N
N
Sakai
S
S
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004712:Endolymphatic Sac / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D007275:Injections, Intravenous; D008954:Models, Biological; D011433:Propranolol / Q000494:pharmacology*
D000804:Angiotensin II; D011433:Propranolol