title: Reduced cellular immune competence of a temperature-sensitive dopa decarboxylase mutant strain of Drosophila melanogaster against the parasite Leptopilina boulardi.
abstract: 1. The melanotic encapsulation response made by larvae of a temperature-sensitive dopa decarboxylase (DDC) mutant strain of Drosophila against the parasitic wasp Leptopilina was severely compromised in hosts with reduced levels of DDC. 2. Dopa and 5,6-dihydroxyindole (DHI) were two hemolymph components identified in hosts exhibiting a melanotic encapsulation response. 3. This is the first study to implicate DDC in insect cellular immune responses, and to provide chemical evidence that the pigment formed during such responses is eumelanin derived from tyrosine.
authors.affiliation: Department of Biology, Loyola University of Chicago, IL 60626.
authors.forename: A J
authors.initials: AJ
authors.lastname: Nappi
authors.forename: Y
authors.initials: Y
authors.lastname: Carton
authors.forename: E
authors.initials: E
authors.lastname: Vass
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D004296:Dopa Decarboxylase / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics / Q000276:immunology*; D006458:Hemolymph; D007111:Immunity, Cellular; D007814:Larva; D013696:Temperature; D014863:Wasps
chemical_list: D002395:Catecholamines; D004296:Dopa Decarboxylase