title: Skin epidermal thickness and vascular density in type 1 diabetes.
abstract: Epidermal skin thickness and vascular density were assessed in skin biopsies obtained from the dorsum of the foot in 28 Type 1 diabetic patients and 17 normal control subjects, matched for age. Epidermal skin thickness did not differ significantly between control subjects (74 +/- 4 (+/- SE) microns) and diabetic patients (78 +/- 4 microns). It was not related to the duration of diabetes and presence of complications. Neither small (capillary) nor large (arteriole/venule) vessel densities differed significantly between control subjects (59 +/- 6 mm-2 and 19 +/- 2 mm-2) and diabetic patients (65 +/- 4 mm-2 and 22 +/- 3 mm-2). Vessel densities were unrelated to the duration of diabetes and presence of complications.
authors.affiliation: Department of Anatomy, Aberdeen Royal Infirmary, University of Aberdeen, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Malik
authors.forename: J
authors.initials: J
authors.lastname: Metcalfe
authors.forename: A K
authors.initials: AK
authors.lastname: Sharma
authors.forename: J L
authors.initials: JL
authors.lastname: Day
authors.forename: G
authors.initials: G
authors.lastname: Rayman
mesh_terms: D000328:Adult; D001160:Arterioles / Q000166:cytology / Q000473:pathology; D001706:Biopsy; D002196:Capillaries / Q000166:cytology / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D000078404:Epidermal Cells; D004817:Epidermis / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values; D012867:Skin / Q000098:blood supply / Q000166:cytology / Q000473:pathology*; D014699:Venules / Q000166:cytology / Q000473:pathology