title: Comparative study on the inhibition of acetylcholinesterase activity in the freshwater fish Cyprinus carpio by mercury and zinc.
abstract: The effects of sublethal concentrations of mercury (0.1mg/l) and zinc (6 mg/l) on acetylcholinesterase activity and acetylcholine content of gill, kidney, intestine, brain, liver and muscle of the freshwater fish Cyprinus carpio at 1, 15 and 30 days of exposure were studied. A significant suppression in acetylcholinesterase activity was recorded in all the organs from both mercury and zinc intoxicated fish at all the exposure periods. Concurrently, a significant increase in the content of acetylcholine in the organs was observed. These changes observed in the organs of mercury treated fish in different exposure periods were in the order 1 greater than 15 less than 30 days and in zinc treated fish 1 greater than 15 greater than 30 days. Further, these changes were greater in magnitude in the brain, liver and muscle (non-osmoregulatory organs) than in the gill, kidney and intestine (osmoregulatory organs) in both metal media.
authors.affiliation: Department of Zoology, Sri Krishnadevaraya University, Anantapur, India.
authors.forename: A
authors.initials: A
authors.lastname: Suresh
authors.forename: B
authors.initials: B
authors.lastname: Sivaramakrishna
authors.forename: P C
authors.initials: PC
authors.lastname: Victoriamma
authors.forename: K
authors.initials: K
authors.lastname: Radhakrishnaiah
mesh_terms: D000109:Acetylcholine / Q000032:analysis; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D005399:Fishes / Q000378:metabolism*; D005880:Gills / Q000737:chemistry; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008628:Mercury / Q000633:toxicity*; D009132:Muscles / Q000737:chemistry; D015032:Zinc / Q000633:toxicity*
chemical_list: D002800:Cholinesterase Inhibitors; D008628:Mercury; D015032:Zinc; D000109:Acetylcholine