title: Cytogenetic findings in liposarcoma correlate with histopathologic subtypes.
abstract: The cytogenetic findings in 31 liposarcomas from 26 patients are reported. Four other tumors did not grow. Three histologic types are represented in this analysis. The well-differentiated liposarcomas were characterized by telomeric associations, large marker chromosomes and ring chromosomes, and in some cases, double minutes. The pleomorphic liposarcomas contained very high clonal chromosomal numbers with near-tetraploid modes and numerous variable, often unidentifiable, chromosomal abnormalities. The myxoid liposarcomas were characterized primarily by a t(12;16)(q13;p11) as the sole abnormality or additional changes. These results indicate that cytogenetic findings may provide a new criterion, not only for establishing the diagnosis of liposarcoma, but also for differentiating confusing histologic types of liposarcoma and these lesions from other types of sarcomas.
authors.affiliation: Cancer Center of Southwest Biomedical Research, Institute and Genetrix, Inc., Scottsdale, Arizona 85251.
authors.forename: C
authors.initials: C
authors.lastname: Sreekantaiah
authors.forename: C P
authors.initials: CP
authors.lastname: Karakousis
authors.forename: S P
authors.initials: SP
authors.lastname: Leong
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D000368:Aged; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D008080:Liposarcoma / Q000235:genetics* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000473:pathology*