title: [Suramin induces lysosomal storage disorder in HT29-D4 cells during a mechanism of polarized endocytosis].
abstract: During the course of suramin-induced differentiation, a marked lysosomal storage disorder is observed in HT29-D4. This impairment could account for the toxic side effects of the drug during clinical trials in humans. It is shown that the perturbation is caused by a process of endocytosis of suramin-serum albumin complexes by the apical membrane of differentiated HT29-D4 cells.
authors.affiliation: Lab. d'Histologie, Fac. de Médecine Secteur Nord, Marseille.
authors.forename: S
authors.initials: S
authors.lastname: Baghdiguian
authors.forename: J A
authors.initials: JA
authors.lastname: Boudier
authors.forename: B
authors.initials: B
authors.lastname: Verrier
authors.forename: J P
authors.initials: JP
authors.lastname: Zappitelli
authors.forename: J
authors.initials: J
authors.lastname: Fantini
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D002461:Cell Line, Transformed; D002471:Cell Transformation, Neoplastic; D002999:Clone Cells / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology; D004705:Endocytosis / Q000187:drug effects*; D016464:Lysosomal Storage Diseases / Q000139:chemically induced* / Q000473:pathology; D013498:Suramin / Q000009:adverse effects*; D014407:Tumor Cells, Cultured / Q000473:pathology
chemical_list: D013498:Suramin
vernacular_title: La suramine provoque une perturbation du système lysosomal des cellules HT29-D4 au cours d'un mécanisme d'endocytose polarisée.