title: Relationship between levodopa-independent symptoms and central atrophy evaluated by magnetic resonance imaging in Parkinson's disease.
abstract: Thirty patients with Parkinson's disease were studied for the purpose of investigation relations between motor symptoms and cerebral atrophy evaluated by magnetic resonance imaging (MRI). Axial symptoms (gait disorder, postural instability and difficulty in arising from a chair), assessed at the time of maximum clinical improvement, were significantly correlated with frontal atrophy, while no correlation was found between the basal parkinsonian disability score and cerebral atrophy. It is suggested that frontal atrophy observed by MRI is linked with axial motor symptoms resulting from non-dopaminergic lesions. The origin of this atrophy is unknown.
authors.affiliation: Clinique Neurologique, Hôpital Fontmaure, Chamalières, France.
authors.forename: F
authors.initials: F
authors.lastname: Durif
authors.forename: P
authors.initials: P
authors.lastname: Pollak
authors.forename: M
authors.initials: M
authors.lastname: Hommel
authors.forename: C
authors.initials: C
authors.lastname: Ardouin
authors.forename: J F
authors.initials: JF
authors.lastname: Le Bas
authors.forename: G
authors.initials: G
authors.lastname: Crouzet
authors.forename: J
authors.initials: J
authors.lastname: Perret
mesh_terms: D000368:Aged; D001284:Atrophy; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D007980:Levodopa