Interaction between ethanol and dextroamphetamine: effects on psychomotor performance.
The objective of this study was to investigate the interaction between ethanol and dextroamphetamine with regard to psychomotor performance. Twelve healthy, male, paid volunteers, moderate users of ethanol and amphetamines, participated in this study. Ethanol (0.85 g/kg or placebo) was administered over a 30-min interval. Five minutes before the termination of ethanol or placebo ingestion, dextroamphetamine elixir (0.09 mg/kg, 0.18 mg/kg or placebo) diluted in 50 ml of orange juice was administered. Subjects were tested in a single-blind, latin-square, crossover design with each of the following six conditions: placebo ethanol/placebo dextroamphetamine; placebo ethanol/low-dose dextroamphetamine; placebo ethanol/high-dose dextroamphetamine; ethanol/placebo dextroamphetamine; ethanol/low-dose dextroamphetamine; and ethanol/high-dose dextroamphetamine. The variables measured in this study were: subjective rating of ethanol and dextroamphetamine intoxication, accuracy and latency of response in the Simulator Evaluation of Drug Impairment (SEDI task), blood ethanol concentration by breath analyzer, and plasma concentrations of dextroamphetamine by gas chromatography. Results indicate ethanol induced decrements in performance of the skills necessary to drive an automobile were significantly decreased by dextroamphetamine in a dose-response fashion. The administration of dextroamphetamine did not decrease the subjective ratings of ethanol intoxication.
Perez-Reyes
M
M
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599-7175.
White
W R
WR
McDonald
S A
SA
Hicks
R E
RE
D000328:Adult; D000428:Alcohol Drinking / Q000097:blood / Q000523:psychology*; D000435:Alcoholic Intoxication / Q000097:blood / Q000523:psychology; D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003913:Dextroamphetamine / Q000493:pharmacokinetics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol / Q000493:pharmacokinetics; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D016037:Single-Blind Method
D000431:Ethanol; D003913:Dextroamphetamine