The content of urokinase-type plasminogen activator antigen as a prognostic factor in urinary bladder cancer.
Urokinase-type plasminogen activator (u-PA) is thought to be implicated in cancer invasion and metastasis. The aim of this study was to determine whether the u-PA content of cancer tissue is a prognostic factor in bladder cancer. Tissue samples from 46 patients with bladder cancer were assessed for u-PA antigen by a highly sensitive enzyme immunoassay. The relationships between the u-PA level in extracts of bladder cancer and the survival rates of the bladder-cancer patients were examined. Patients with a high u-PA level (8 ng/mg of protein and more) showed a statistically significantly higher rate of survival than those with a low u-PA level (p less than 0.005). The u-PA antigen level in cancer tissue was significantly lower in low-graded and non-invasive cancers than in others (p less than 0.01).
Hasui
Y
Y
Department of Urology, Miyazaki Medical College, Japan.
Marutsuka
K
K
Suzumiya
J
J
Kitada
S
S
Osada
Y
Y
Sumiyoshi
A
A
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D001706:Biopsy; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis* / Q000097:blood
D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; D014568:Urokinase-Type Plasminogen Activator