Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease.
We report the presence of autophagic vacuoles (AV) in neuronal perikarya and neuronal processes of rodents with experimental scrapie and Creutzfeldt-Jakob disease. AV were composed of sequestrated cytoplasmic areas containing ribosomes and occasionally mitochondria and small secondary vacuoles. The formation of AV may contribute to neuronal degeneration and ultimately to neuronal loss.
Liberski
P P
PP
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Yanagihara
R
R
Gibbs
C J
CJ
Gajdusek
D C
DC
D000818:Animals; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology*; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology; D009474:Neurons / Q000648:ultrastructure*; D012270:Ribosomes / Q000648:ultrastructure; D012608:Scrapie / Q000473:pathology*