An experimental model of ameboma in guinea pig.
Among the wide variety of clinicopathological manifestations of intestinal amebiasis, amebomas occur rarely and their pathogenesis is not well understood. When cholesterol-fed, 2- to 4-week-old guinea pigs were infected intracecally with a virulent, monoaxenic strain of Entamoeba histolytica, gross and histologically characteristic amebomas developed in 85% of the animals by the 3rd day, in 94% by the 9th day, and in 96% by the 12th day postinfection, by which time most of them had died. Amebomas were confirmed by histopathology. Thus, a model of consistent production of amebomas was documented.
Bhatti
H S
HS
Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Bhushnurmath
S
S
Mahajan
R C
RC
Ganguly
N K
NK
Sehgal
R
R
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D002429:Cecal Diseases / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D002432:Cecum / Q000469:parasitology / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004404:Dysentery, Amebic / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D004748:Entamoeba histolytica / Q000276:immunology / Q000302:isolation & purification; D005260:Female; D006099:Granuloma / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D006168:Guinea Pigs; D008297:Male; D009336:Necrosis; D010503:Periodic Acid-Schiff Reaction
D000913:Antibodies, Protozoan; D002784:Cholesterol