title: Squamous-cell carcinoma of the scrotum.
abstract: Squamous-cell carcinoma of the scrotum has a poor prognosis unless locally confined. Patients with stage A1 disease have approximately a 75% or better chance for long-term survival. Occupation-related and -induced scrotal carcinomas are less frequent now because of better hygiene, protective clothing, and awareness of the carcinogenicity of industrial oils. A rise in the incidence of the disease might result from the HPV epidemic. The basic treatment of squamous-cell carcinomas of the scrotum still depends on wide local excision of the primary lesion. Patients should be treated with a broad-spectrum antibiotic for 4 to 6 weeks prior to sentinel node biopsy or ilioinguinal lymphadenectomy. Sentinel node biopsy should be performed to rule out micrometastasis and to establish the need for a formal ilioinguinal lymphadenectomy. Radiation therapy has little therapeutic benefit in the management of squamous-cell carcinoma of the scrotum. Bleomycin might be useful as adjuvant therapy for widespread ilioinguinal disease before attempted resection, although this has yet to be proved.
authors.affiliation: Department of Urology, St. Luke's/Roosevelt Hospital Center, New York, New York.
authors.forename: F C
authors.initials: FC
authors.lastname: Lowe
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000266:history / Q000628:therapy; D005834:Genital Neoplasms, Male / Q000453:epidemiology / Q000266:history / Q000628:therapy; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000266:history; D012611:Scrotum; D014481:United States / Q000453:epidemiology