Cerebrovascular accidents following hormonochemotherapy in cancer patients.
It has become increasingly apparent that the administration of cytotoxic drugs or hormones may be associated with life-threatening vascular episodes. We report on seven women and one man who developed cerebrovascular accident (CVA) during or immediately after the administration of several hormonochemotherapeutic regimens. No patient died from the stroke. Five patients made a complete recovery; one showed remarkable improvement, and two, slight improvement. Several explanations for CVA were proposed, but the pathophysiological basis of the relationship between the arterial occlusive complication and hormonochemotherapy is unclear.
Pectasides
D
D
First Department of Medical Oncology, Metaxas Memorial Cancer Hospital, Piraeus, Greece.
Barbounis
V
V
Athanassiou
A
A
Mariatos
P
P
D000328:Adult; D000792:Angiography; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002544:Cerebral Infarction / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed