title: Fluoxetine-induced psoriasis.
abstract: BACKGROUND
  A number of medications have been reported to induce psoriasis. We report two cases of fluoxetine-related psoriasis and discuss similarities between lithium-, trazodone hydrochloride-, and fluoxetine-induced psoriasis.
  
  
  METHODS
  Two women being treated for depression with fluoxetine developed psoriasis after 6 and 12 months' exposure. This time frame is clinically similar to that observed with lithium-induced psoriasis.
  
  
  CONCLUSIONS
  The occurrence of lithium- and fluoxetine-induced psoriasis may not be random. Both drugs modulate serotonergic function, a factor that may contribute to the pathophysiology of psoriasis. If a patient on acute or long-term fluoxetine therapy develops psoriasis, the drug should be considered as a possible etiologic agent.
authors.affiliation: Mount Sinai School of Medicine, New York, NY.
authors.forename: C
authors.initials: C
authors.lastname: Hemlock
authors.forename: J S
authors.initials: JS
authors.lastname: Rosenthal
authors.forename: A
authors.initials: A
authors.lastname: Winston
mesh_terms: D000328:Adult; D003863:Depression / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008094:Lithium / Q000009:adverse effects; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced*
chemical_list: D005473:Fluoxetine; D008094:Lithium