Long-term treatment in infantile choriocarcinoma.
The long-term treatment of a 5 month old boy with precocious puberty secondary to the production of chorionic gonadotropin (hCG) by a choriocarcinoma is described. Of 13 cases of infantile choriocarcinoma reported in the literature, none were successfully treated. The present study describes a partially successful outcome with embolization of a hepatic tumor, irradiation of lung and right submandibular tumors, chemotherapy with methotrexate (MTX), actinomycin D (ACD), cyclophosphamide (CPA) and etoposide (VP16), and splenectomy and hepatic lobectomy. Subsequently, the residual hepatic tumors were treated with high dose melphalan (HDM) followed by reinfusion of unpurged autologous marrow.
Hongo
T
T
Department of Pediatrics, Hamamatsu University School of Medicine, Japan.
Fujii
Y
Y
Fukuoka
T
T
Iijima
S
S
Matsusita
T
T
Nakagawa
Y
Y
Igarashi
Y
Y
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D017024:Chemotherapy, Adjuvant; D002675:Child, Preschool; D002822:Choriocarcinoma / Q000378:metabolism / Q000628:therapy*; D006063:Chorionic Gonadotropin / Q000096:biosynthesis*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004621:Embolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009378:Neoplasms, Multiple Primary / Q000628:therapy*; D011239:Prednisolone / Q000008:administration & dosage; D011629:Puberty, Precocious / Q000209:etiology*; D013365:Submandibular Gland Neoplasms / Q000378:metabolism / Q000628:therapy*; D014747:Vinblastine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D006063:Chorionic Gonadotropin; D003609:Dactinomycin; D014750:Vincristine; D014747:Vinblastine; D003520:Cyclophosphamide; D011239:Prednisolone; D008727:Methotrexate