title: A distributed model of exchange processes within the osteon.
abstract: In order to understand various exchange processes within the osteon, a mathematical model to describe the system has been developed which allows for concentration gradients in the axial and radial directions as well as cellular consumption and binding to bone surface. The normal values for the model parameter are discussed and the effects of the model parameters on the behaviour of the model are investigated. This model supports the idea that diffusion alone may be an inefficient mechanism in transport between blood and osteocytes.
authors.affiliation: Department of Orthopaedic Surgery, University of Edinburgh, Medical School, U.K.
authors.forename: I D
authors.initials: ID
authors.lastname: McCarthy
authors.forename: L
authors.initials: L
authors.lastname: Yang
mesh_terms: D001692:Biological Transport; D001857:Bone Matrix / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002196:Capillaries / Q000378:metabolism; D002199:Capillary Permeability; D005110:Extracellular Space / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006253:Haversian System / Q000033:anatomy & histology / Q000098:blood supply / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D010011:Osteocytes / Q000378:metabolism; D012039:Regional Blood Flow
chemical_list: D005947:Glucose; D002118:Calcium