title: Simultaneous occurrence of t(14;18) and t(8;22) common acute lymphoblastic leukemia.
abstract: A young male patient progressed rapidly from localized abdominal lymph node enlargement to overt acute lymphoblastic leukemia. Despite aggressive treatment, he died of progressive CNS leukemia 5 months after initial presentation. At diagnosis, karyotypic analysis of an abdominal lymph node revealed the coexistence of t(14;18) (q32;q21), specific for follicular lymphoma, and t(8;22) (q24;q11), a variant Burkitt translocation. Such cases might be considered as a model for a general mechanism of tumor progression with cascade-like involvement of oncogenes.
authors.affiliation: First Department of Medicine, University of Vienna, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Marosi
authors.forename: P
authors.initials: P
authors.lastname: Bettelheim
authors.forename: A
authors.initials: A
authors.lastname: Chott
authors.forename: U
authors.initials: U
authors.lastname: Köller
authors.forename: G
authors.initials: G
authors.lastname: Kreiner
authors.forename: G
authors.initials: G
authors.lastname: Steger
authors.forename: U
authors.initials: U
authors.lastname: Jäger
authors.forename: H
authors.initials: H
authors.lastname: Pirc-Danoewinata
authors.forename: K
authors.initials: K
authors.lastname: Lechner
mesh_terms: D000328:Adult; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic