Preparation and investigation of inclusion complexes containing nitrazepam.
Nitrazepam is a valuable drug, being one of the often used minor tranquillizers in psychotherapy. However, its solubility characteristics are very unfavourable. Products were prepared with dimethyl-beta-cyclodextrin in different combinations (8.58%, 19.48% and 27.29%) and by several methods such as mixing, kneading, precipitation and spray-drying.
Czékus
G
G
Department of Pharmaceutical Technology, Albert Szent-Györgyi Medical University, Szeged.
Jung
N
N
Kata
M
M
D003505:Cyclodextrins / Q000737:chemistry; D009567:Nitrazepam / Q000737:chemistry*; D012995:Solubility
D003505:Cyclodextrins; D009567:Nitrazepam