Behavioural effects after cholinergic stimulation of the reticular thalamic nucleus in rats.
This study investigated the functional relationship between the experimentally induced changes in the activity of the cholinergic, muscarinergic system of the rostral area of the nucleus reticularis thalami (TRN) and the motor behaviour. The effect of direct stimulation of the rostral TRN by the cholinergic agonist carbachol on the behaviour of freely moving rats was observed. Unilateral injection of carbachol (0.2-3.2 micrograms/0.5 microliters) into the rostral TRN caused catalepsy which appeared rapidly and was short-lasting. Furthermore, it induced impairment of the performance on the rota rod. Both effects were dose-dependent. The cholinergic antagonist scopolamine (6.66 micrograms) coadministered with the equimolar dose of carbachol (3.2 micrograms) antagonized the effects of carbachol on both behavioural tests. The described effects seem to be cholinergic- and site-specific within the rostral TRN. The present results suggest that activation of the cholinergic, muscarinergic receptors in the rostral TRN modulate the motor function of rats.
Kolasiewicz
W
W
Department of Neuro-Psychopharmacology, Polish Academy of Sciences, Krakow.
Sauss
C
C
Block
F
F
Sontag
K H
KH
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology; D002217:Carbachol / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology*; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000502:physiology*; D012601:Scopolamine / Q000494:pharmacology; D013787:Thalamic Nuclei / Q000502:physiology*
D002217:Carbachol; D012601:Scopolamine