Common variable immunodeficiency in a family.
Common variable immunodeficiency (CVID) is mainly characterised by hypo- or agammaglobulinaemia of late onset, usually discovered in the second decade of life. In individuals CVID is associated with a variable impairment of cellular immunity and the susceptibility to microbial infection may vary as well. CVID is described in a mother and a son who suffered from serious bacterial infections. In addition, minor immunological test abnormalities of apparently healthy first degree relatives are described.
Van Spronsen
D J
DJ
Department of Internal Medicine, Oncology/AIDS division, Medisch Spectrum Twente/Ziekenhuis Enschede, Netherlands.
Kerbert-Dreteler
M
M
van der Sluijs Veer
G
G
ten Napel
C H
CH
D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics* / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010375:Pedigree
D007136:Immunoglobulins