title: Cytology of transitional-cell carcinoma of the urinary bladder: diagnostic yield and histologic basis.
abstract: The diagnostic yield of cytology in histologically proven transitional-cell carcinoma (TCC) of the urinary bladder has been studied in 100 cases. Cytohistologic correlation rates were 20 percent, 61.7 percent, and 92.8 percent, respectively, for grade 1, 2, and 3 tumors. When further evaluated, G2 cases were segregated into 2 subcategories, G2a and G2b, based on histologic preservation of nuclear polarity, pleomorphism, and other cellular irregularities. Correlation rates were rather low for G2a cases (6/18, 33%) and high for G2b cases, (23/29; 79%). The prevalence of atypical cells was 2 (11.1%) cases in G2a and 16 (55.2%) cases in G2b. The results of this study confirm that cytology has an extremely varying diagnostic yield in urinary bladder TCC. Greater cell exfoliation, increased atypia, and a tendency to infiltration of G2b and G3 cases probably account for the higher diagnostic yield detected in these groups.
authors.affiliation: Department of Anatomic Pathology, University of Trieste, Italy.
authors.forename: L
authors.initials: L
authors.lastname: DiBonito
authors.forename: M M
authors.initials: MM
authors.lastname: Musse
authors.forename: S
authors.initials: S
authors.lastname: Dudine
authors.forename: G
authors.initials: G
authors.lastname: Falconieri
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000652:urine; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000652:urine