Synthesis and optical resolution of an antiallergic agent KW4099 with thromboxane A2 antagonistic activity.
A new antiallergic agent with thromboxane A2 antagonistic activity, KW4099, was synthesized by a simple method. Its optical resolution was accomplished with the use of (+)- or (-)-2,2'-(1,1'-binaphthyl)phosphoric acid as a resolving agent.
Sugaya
T
T
Sakai Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Osaka, Japan.
Kuge
Y
Y
Tomioka
S
S
Tamaki
K
K
D003990:Dibenzoxepins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006967:Hypersensitivity / Q000188:drug therapy; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
D003990:Dibenzoxepins; D010880:Piperidines; C074371:KW 4099; D013928:Thromboxane A2