Inhibitory effects of (1E,3E,5E,7E)-5-hydroxy-4-(8-phenyl-1,3,5,7- octatetraenyl)-2(5H)-furanone on proliferation of human malignant tumor cells.
A butenolide compound (1E,3E,5E,7E)-5-hydroxy-4-(8-phenyl-1,3,5,7- octatetraenyl)-2(5H)-furanone (KNK-41), was shown to have strong anti-tumor activity. KNK-41 inhibited the proliferation of various kinds of human malignant tumor cells, such as HeLa (cervical carcinoma), HGC-27 (gastric cancer), PANC-1 (pancreatic cancer) and GOTO (neuroblastoma). Flow cytometric analysis indicated that KNK-41 caused an arrest in G0/G1 phase of the cell cycle. However, it scarcely affected DNA synthesis and the level of c-myc mRNA. These results suggest that the growth-inhibitory effect of KNK-41 is the result of G0/G1 arrest and not of the suppression of DNA synthesis and/or c-myc expression.
Satomi
Y
Y
Department of Biochemistry, Kyoto Prefectural University of Medicine, Japan.
Nishino
H
H
Iwashima
A
A
Torihara
M
M
Tamai
Y
Y
Ito
M
M
D015107:4-Butyrolactone / Q000031:analogs & derivatives; D000970:Antineoplastic Agents / Q000494:pharmacology*; D015152:Blotting, Northern; D002338:Carotenoids / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000187:drug effects; D005434:Flow Cytometry; D005663:Furans / Q000494:pharmacology*; D016259:Genes, myc; D006367:HeLa Cells; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009447:Neuroblastoma / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology; D012333:RNA, Messenger / Q000187:drug effects; D013274:Stomach Neoplasms / Q000473:pathology; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000473:pathology
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D005663:Furans; D009363:Neoplasm Proteins; D012333:RNA, Messenger; C074393:5-hydroxy-4-(8-phenyl-1,3,5,7-octatetraenyl)-2(5H)-furanone; C016040:peridinin; D002338:Carotenoids; C004511:butenolide; D015107:4-Butyrolactone; D013936:Thymidine