title: Bacterial vaginosis: treatment with clindamycin cream versus oral metronidazole.
abstract: In a randomized, double-blind study, 48 women with symptomatic bacterial vaginosis were assigned to receive either 5 g of 2% clindamycin vaginal cream daily or 500 mg metronidazole oral tablets twice a day for 7 days. After completion of therapy, there was no significant difference in cure rates (clindamycin 72% versus metronidazole 87%). One month later, 61% of the patients in each group were still cured. Adverse reactions were mild in both groups. We conclude that clindamycin cream is a safe, well tolerated, and effective alternative to oral metronidazole for treatment of bacterial vaginosis.
authors.affiliation: Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: C
authors.initials: C
authors.lastname: Schmitt
authors.forename: J D
authors.initials: JD
authors.lastname: Sobel
authors.forename: C
authors.initials: C
authors.lastname: Meriwether
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002981:Clindamycin / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011446:Prospective Studies; D014622:Vaginal Creams, Foams, and Jellies; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
chemical_list: D014622:Vaginal Creams, Foams, and Jellies; D008795:Metronidazole; D002981:Clindamycin