title: Synthesis and O-demethylation rate of cis-[Pt(NH3)2(O6,9-dimethylguanine-7)2]Cl2: a study of the demethylation mechanism of O6-methylguanine-DNA methyltransferase.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kohda
authors.forename: I
authors.initials: I
authors.lastname: Terashima
authors.forename: N
authors.initials: N
authors.lastname: Sawada
authors.forename: I
authors.initials: I
authors.lastname: Nozaki
authors.forename: M
authors.initials: M
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Kawazoe
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000737:chemistry; D003640:Dealkylation; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008780:Methyltransferases / Q000378:metabolism*; D019853:O(6)-Methylguanine-DNA Methyltransferase; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000378:metabolism*
chemical_list: D009944:Organoplatinum Compounds; C074484:cis-diamminebis(O(6),9-dimethylguanine-7)platinum(II); D006147:Guanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase; D002945:Cisplatin