Inoculated mouse model of Pneumocystis carinii infection.
A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice. The advantage of this strain of mice include that they are widely available, inexpensive, and were not infected with Pneumocystis before inoculation. Inoculated mice that were not treated had a mean infectivity score of 4.1 compared with inoculated mice treated with the effective anti-Pneumocystis drug combination of trimethoprim plus sulfamethoxazole, which had a mean infectivity score of 0.1, an approximately 4 log difference. The inoculated BALB/c mouse provides a model to serve as a valuable addition to rat models currently used, providing a source of organisms from a different host for cross-species comparisons and for studies of drug efficacy for therapy and prophylaxis. The inoculated mouse is especially cost effective and allows testing of compounds in short supply.
Bartlett
M S
MS
Department of Pathology, Indiana University School of Medicine, Indianapolis 46202-5250.
Queener
S F
SF
Durkin
M M
MM
Shaw
M A
MA
Smith
J W
JW
D000634:Aminoquinolines / Q000627:therapeutic use; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D003907:Dexamethasone; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D016720:Pneumocystis Infections / Q000188:drug therapy / Q000276:immunology* / Q000517:prevention & control; D011319:Primaquine / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D000634:Aminoquinolines; D000962:Antimalarials; C055852:tafenoquine; D002981:Clindamycin; D003907:Dexamethasone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D011319:Primaquine