Pathologic changes induced by phospholipase A2 isolated from the venom of Collett's snake, Pseudechis colletti: a light and electron microscopic study.
Pseudechis colletti is an Australian elapid snake with a range limited to central Queensland, Australia. The venom of this snake, as well as that of several other Australian elapids, has been shown to contain a phospholipase A2 (PLA2) which can cause a marked myoglobinuria in mice. Few studies have described the histopathologic and ultrastructural changes that result from myotoxic PLA2-induced damage. Our investigation demonstrated that the isolated PLA2 induced myodegeneration and necrosis in myocardium in a dose-related manner, with subsequent myoglobinuria and myoglobinuric nephropathy.
Weinstein
S A
SA
Department of Toxinology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011.
Bell
R C
RC
Brown
C R
CR
Fletcher
J E
JE
Smith
L A
LA
D000818:Animals; D004546:Elapid Venoms / Q000201:enzymology* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009132:Muscles / Q000187:drug effects* / Q000648:ultrastructure; D010741:Phospholipases A / Q000378:metabolism / Q000633:toxicity*; D054467:Phospholipases A2
D004546:Elapid Venoms; D010741:Phospholipases A; D054467:Phospholipases A2