title: Evaluation of serum levels of soluble interleukin-2 receptor as an indicator of disease activity in systemic lupus erythematosus.
abstract: Serum levels of the soluble form of the interleukin-2 receptor (sIL-2R) were measured in the sera of 32 patients with systemic lupus erythematosus. A significant correlation was observed between the levels of sIL-2R and the SLAM score of disease activity (R:0.40; p: less than 0.05). The correlation was slightly lower than those between the SLAM score and the levels of anti-dsDNA or of the complement activity. The levels of sIL-2R were not significantly correlated with those of serum anti-ds-DNA and complement, nor with a sign of peripheral blood B cell hyperactivity, such as the spontaneous in vitro production of anti-DNA antibodies.
authors.affiliation: Servizio di Immunologia Clinica, Spedali Civili, Brescia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Airŏ
authors.forename: S
authors.initials: S
authors.lastname: Braga
authors.forename: E
authors.initials: E
authors.lastname: Prati
authors.forename: D
authors.initials: D
authors.lastname: Brugnoni
authors.forename: M
authors.initials: M
authors.lastname: Bettinzioli
authors.forename: R
authors.initials: R
authors.lastname: Gorla
authors.forename: R
authors.initials: R
authors.lastname: Cattaneo
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012720:Severity of Illness Index
chemical_list: D000974:Antibodies, Antinuclear; D015375:Receptors, Interleukin-2