title: Clinical and laboratory features of type 1 diabetic children at the time of diagnosis.
abstract: The French incidence study has registered all new cases of Type 1 diabetic children under 20 years of age, from a population of 2.32 million, in an exhaustive and prospective manner. Three hundred and forty cases were identified between 1 January 1988 and 31 December 1989, yielding a mean annual incidence rate 7.3 per 10(5). The lowest rate was observed in the youngest age group (0-4 yr: 4.1 per 10(5)) and the highest around pubertal development (10-14 yr: 11.5 per 10(5)). Details of the previous personal and family history, and the clinical and biological pictures of the disease at diagnosis were recorded. Almost 8 per cent of the children had a first-degree relative with Type 1 diabetes. Polyuria, weight loss, fatigue and abdominal pain were the most frequently reported symptoms, which were of median duration 4.4 months. Mean weight loss before diagnosis was 9.4 +/- 6.8 (+/- SD)% of body weight and was not significantly related to age. Ketonuria was detected in 83.8 per cent and acidosis (total CO2 less than or equal to 18 mmol l-1, if measured) in 48 per cent of the cases. Ketonuria and acidosis were significantly more frequent in the younger age group than in the rest of the group (p less than 0.001).
authors.affiliation: Department of Diabetology, Robert Debré Hospital, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Lévy-Marchal
authors.forename: L
authors.initials: L
authors.lastname: Papoz
authors.forename: C
authors.initials: C
authors.lastname: de Beaufort
authors.forename: J
authors.initials: J
authors.lastname: Doutreix
authors.forename: V
authors.initials: V
authors.lastname: Froment
authors.forename: J
authors.initials: J
authors.lastname: Voirin
authors.forename: P
authors.initials: P
authors.lastname: Czernichow
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D016640:Diabetes, Gestational / Q000235:genetics; D005190:Family; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D011247:Pregnancy; D012042:Registries
chemical_list: D001786:Blood Glucose