T-cell mitogenic responses in fully xenogeneic chimeras (WF rat----B10 mouse) are restored by blocking the L-arginine-dependent nitric oxide pathway.
Wren
S M
SM
Department of Surgery, University of Pittsburgh, Pennsylvania 15261.
Hoffman
R A
RA
Billiar
T R
TR
Abou el Ezz
A
A
Hronakes
M L
ML
Ildstad
S T
ST
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002478:Cells, Cultured; D002678:Chimera / Q000276:immunology*; D003208:Concanavalin A; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009569:Nitric Oxide / Q000378:metabolism*; D037121:Plant Lectins; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014183:Transplantation, Heterologous / Q000276:immunology; D019323:omega-N-Methylarginine
D037121:Plant Lectins; D003208:Concanavalin A; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine