Antiproliferative action of prostatic inhibin on NRK-49F and BALB/c 3T3 cell lines.
Prostatic inhibin purified from human seminal plasma (10.7 kDa, 94 amino acids) is very well known for its endocrine action on pituitary to suppress synthesis and secretion of FSH. In the present report we have revealed its antiproliferative action on two fibroblast cell lines, NRK-49F (ED50 = 2.5 ng/ml) and Balb/c 3T3 (ED50 = 24.5 ng/ml) which may mark its emergence as a negative growth regulator.
Mundle
S D
SD
Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India.
Rao
S G
SG
Sheth
N A
NA
D016475:3T3 Cells / Q000187:drug effects; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007265:Inhibins / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011467:Prostate / Q000737:chemistry*
D007265:Inhibins; D004247:DNA