Myasthenia gravis with thymoma is not associated with an increased incidence of non-muscle autoimmune disorders.
Three groups of thymectomized patients with myasthenia gravis (MG) were selected for study, 16 with thymoma, 16 with thymic atrophy and 32 with follicular hyperplasia of the thymus. All 16 patients with thymoma, 15/16 with thymus atrophy and 30/32 with follicular hyperplasia had AChR antibodies. Non-receptor muscle (CA) antibodies were found in sera of 15/16 patients with thymoma, 3/16 with thymus atrophy and in none of the sera from patients with follicular hyperplasia. There were 2 patients with thymoma and polymyositis, but none of the thymoma patients had rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or other autoimmune disorders. Among the 32 patients with follicular hyperplasia of the thymus were 2 with SLE, 2 with RA and 1 with juvenile diabetes mellitus. In this study, there was an increased incidence of non-muscle autoimmune disorders among MG patients with follicular hyperplasia of the thymus but not among MG patients with thymoma.
Aarli
J A
JA
Department of Neurology, Gade Institute, University Hospital, University of Bergen, Norway.
Gilhus
N E
NE
Matre
R
R
D000328:Adult; D000368:Aged; D001284:Atrophy; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000276:immunology; D009157:Myasthenia Gravis / Q000209:etiology*; D011978:Receptors, Nicotinic / Q000276:immunology; D013934:Thymectomy; D013945:Thymoma / Q000150:complications* / Q000601:surgery; D013950:Thymus Gland / Q000473:pathology; D013953:Thymus Neoplasms / Q000150:complications* / Q000601:surgery
D001323:Autoantibodies; D011978:Receptors, Nicotinic