Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography.
There have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. In this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sites for dopamine, serotonin and norepinephrine using qualitative autoradiography. No effects of cocaine on any of the binding sites were observed and therefore, it is concluded that cocaine, unlike amphetamine derivatives which have similar pharmacologic properties, does not produce neurotoxic effects on monoamine neurons.
Benmansour
S
S
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia.
Tejani-Butt
S M
SM
Hauptmann
M
M
Brunswick
D J
DJ
D000818:Animals; D001345:Autoradiography; D015306:Biogenic Monoamines / Q000378:metabolism* / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D007099:Imipramine / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008454:Mazindol / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000378:metabolism; D011954:Receptors, Dopamine / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology
D015306:Biogenic Monoamines; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C024316:cianopramine; D008454:Mazindol; D003042:Cocaine; D007099:Imipramine; D009638:Norepinephrine