title: Perspectives on the origins of multiple myeloma and plasmacytomas in mice.
abstract: The natural history of multiple myeloma and related human plasma cell tumors is compared to the process of plasmacytomagenesis in mice. Intriguing new findings are beginning to give a more complete picture of the evolution of these tumors. Mouse plasmacytomas consistently develop chromosomal translocations that dysregulate c-myc, but consistent oncogenic mutations have not yet been defined in multiple myeloma.
authors.affiliation: Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland.
authors.forename: M
authors.initials: M
authors.lastname: Potter
mesh_terms: D000818:Animals; D051379:Mice; D008815:Mice, Inbred Strains; D009101:Multiple Myeloma / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D010950:Plasma Cells / Q000473:pathology; D010954:Plasmacytoma / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D014178:Translocation, Genetic