[Significance of the level of carcinoembryonic antigen in the alveolar lavage fluid in cancerous and non-cancerous bronchopulmonary pathology].
In a prospective study the level of carcinoembryonic antigen (ACE) were simultaneously measured in plasma and bronchoalveolar lavage liquid (LBA), in fifteen patients suffering from bronchopulmonary cancer and fifteen patients suffering from non-malignant pulmonary disease. In these two groups the level of ACE in LBA liquid (cancer 8,990 +/- 4,050 ng/ml; controls 2,510 +/- 1,060 ng/ml) were clearly more elevated than the corresponding plasma levels (cancer 1,931 +/- 1,760 ng/ml; controls 8.2 +/- 2 ng/ml) and the plasma levels of ACE were more elevated in the cancer group; in the same group the ACE levels in the LBA liquid were more elevated in the tumour group (4,770 +/- 2,180 ng/ml versus 808 +/- 300 ng/ml). This study has also shown the elevated levels of ACE in the LBA liquid in patients suffering from chronic bronchial inflammation (2,510 +/- 1,060 ng/ml) and during the course of acute bacterial pneumonia. The contribution of the ACE level in LBA liquid in relation to the plasma levels in the diagnosis of bronchopulmonary cancer would thus appear to have no clinical value, but the exact relationships between the phenomenon of chronic bronchial inflammation and metaplasia of the bronchial epithelium merit further study.
Menard
O
O
Service de Pneumologie, Hôpital de Brabois, Vandoeuvre-lès-Nancy.
Dousset
B
B
Jacob
C
C
Anthoine
D
D
Martinet
Y
Y
D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D002277:Carcinoma / Q000097:blood / Q000737:chemistry; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000378:metabolism*; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000378:metabolism; D008175:Lung Neoplasms / Q000097:blood / Q000737:chemistry*; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000097:blood / Q000378:metabolism; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen
Signification des taux d'antigène carcino-embryonnaire dans le liquide de lavage alvéolaire en pathologie bronchopulmonaire cancéreuse et non cancéreuse.