title: Effect of total gastrectomy on remnant islet cell function after major pancreatectomy in rats.
abstract: This study was designed to investigate the effect of total gastrectomy on remnant islet cell function after 85% distal pancreatectomy in rats. Eight-week-old Wistar male rats were divided into the following three groups: group 1, laparotomy; group 2, distal pancreatectomy; and group 3, distal pancreatectomy with total gastrectomy. Four weeks after the operation, i.v. glucose tolerance tests (ivGTT) were performed. The body weight in group 3 rats 4 weeks after the operation was significantly lower than that of the other two groups (p less than 0.05). Glucose tolerance was impaired in both groups 2 and 3; group 3 was more impaired than group 2. Immunoreactive insulin (IRI) concentration in both groups 2 and 3 was much lower than that in group 1 throughout the ivGTT. Furthermore, IRI concentration in group 3 was lower than group 2 at all times. The integrated secretion of insulin for the 45 minutes after glucose injection was lower in group 3 than in group 2. It is concluded that total gastrectomy injures remnant pancreatic endocrine function after 85% distal pancreatectomy in rats.
authors.affiliation: Department of Surgery II, Yamaguchi University School of Medicine, Ube, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Shinagawa
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D005743:Gastrectomy; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test; D007275:Injections, Intravenous; D007515:Islets of Langerhans / Q000502:physiology*; D008297:Male; D010179:Pancreas / Q000502:physiology / Q000601:surgery; D010180:Pancreatectomy; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000502:physiology / Q000601:surgery; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D005947:Glucose