title: [Prognostic parameters in localized breast cancer].
abstract: About 8% of women in Norway will develop breast cancer. 55% of these will have a node negative disease. The current debate concerns whether all women in stage I should be treated with adjuvant therapies. In this article we discuss different prognostic factors with the objective of subdividing node negative breast cancer patients into different prognostic groups. Risk factors include age under 30 years and over 70 years, increasing size of tumour, a high histological grade and negative oestrogen receptor status. We believe that, in future, evaluation of ploidy, proliferation antigens, oncogenes and possibly cathepsin D will be useful in selecting breast cancer patients in stage I for adjuvant therapy.
authors.affiliation: Avdeling for patologi, Det Norske Radiumhospital, Oslo.
authors.forename: W
authors.initials: W
authors.lastname: Reed
authors.forename: S
authors.initials: S
authors.lastname: Gundersen
authors.forename: P E
authors.initials: PE
authors.lastname: Lønning
authors.forename: J M
authors.initials: JM
authors.lastname: Nesland
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D012307:Risk Factors
chemical_list: D011960:Receptors, Estrogen
vernacular_title: Prognostiske parametere ved lokalisert brystkreft.