Antitumour activity of mononuclear phagocytes: role of tumour necrosis factor alpha.
Tumour necrosis factor alpha (TNF) is a cytokine produced by mononuclear phagocytes (MP) originally discovered for its cytotoxic activity on tumour cell targets. It was subsequently demonstrated that, in addition to its oncolytic potential, TNF exerts a wide variety of activities on the host defensive system against malignancies. This article briefly reviews the current concepts on the role of TNF in the antitumour activity of MP.
Spatafora
M
M
Consiglio Nazionale delle Ricerche, Istituto di Fisiopatologia Respiratoria, Università di Palermo, Italy.
Gjomarkaj
M
M
Merendino
A
A
Melis
M
M
Chiappara
G
G
Pace
E
E
D003602:Cytotoxicity, Immunologic / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000235:genetics; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D010586:Phagocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology* / Q000627:therapeutic use
D014409:Tumor Necrosis Factor-alpha