title: An evaluation of buffered aspirin and aspirin tablets in postoperative pain after third molar surgery.
abstract: 1. Single doses (500 and 1000 mg) of both buffered aspirin and aspirin tablets were compared with placebo in a randomised double-blind trial of parallel design in patients with postoperative pain after third molar surgery. 2. Only buffered aspirin 500 mg provided significant pain relief (P = 0.016) during the 5 h investigation period. 3. A significant correlation (P = 0.004) was observed between overall pain scores after the various aspirin treatments and aspirin esterase activity. 4. Buffered aspirin preparations afforded a slight advantage over aspirin tablets in the control of postoperative pain after third molar surgery. However, the duration of analgesia was short (approximately 2 h). 5. Aspirin esterase activity appears to be an important determinant of the drug's efficacy in postoperative dental pain.
authors.affiliation: Department of Operative Dentistry, Dental School, Newcastle upon Tyne.
authors.forename: R A
authors.initials: RA
authors.lastname: Seymour
authors.forename: M
authors.initials: M
authors.lastname: Weldon
authors.forename: P
authors.initials: P
authors.lastname: Kelly
authors.forename: E
authors.initials: E
authors.lastname: Nicholson
authors.forename: J E
authors.initials: JE
authors.lastname: Hawkesford
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D002021:Buffers; D005260:Female; D006801:Humans; D008297:Male; D008964:Molar, Third / Q000601:surgery*; D010149:Postoperative Pain / Q000188:drug therapy*; D013607:Tablets
chemical_list: D002021:Buffers; D013607:Tablets; D001241:Aspirin