title: Radiation of jejunal interposition in T3-T4 upper aerodigestive tumours.
abstract: 30 patients with T3 and T4 tumours of the upper aerodigestive tract had their tumours resected by pharyngolaryngectomy. This was followed by reconstruction of a gullet or creation of a siphon as a tracheohypopharyngeal shunt for voice restoration with a free jejunal autograft. All patients were treated postoperatively with 60Co gamma radiation, 6 MeV photons or 7.5 to 10 MeV electrons of a beta-tron, with a dose of 50-65 Gy in the area of the primary tumour and 50-65 Gy to the neck. 4 patients refused further treatment after a depth dose of between 16 and 32 Gy. Local recurrence occurred in 40% of cases. The survival rate was 36.6% (11/30) after a mean follow-up time of 21.5 months, although 2 patients died of intercurrent diseases without recurrence of their tumours. The results obtained justify active surgical intervention with postoperative irradiation even at an advanced stage of the tumour.
authors.affiliation: Vienna University Clinic of Radiotherapy and Radiobiology, Austria.
authors.forename: L
authors.initials: L
authors.lastname: Handl-Zeller
authors.forename: G
authors.initials: G
authors.lastname: Hohenberg
authors.forename: M
authors.initials: M
authors.lastname: Grasl
authors.forename: C
authors.initials: C
authors.lastname: Stanek
authors.forename: H
authors.initials: H
authors.lastname: Piza
authors.forename: R
authors.initials: R
authors.lastname: Roka
authors.forename: K
authors.initials: K
authors.lastname: Ehrenberger
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D003679:Deglutition / Q000502:physiology; D005260:Female; D006801:Humans; D007583:Jejunum / Q000637:transplantation*; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D010611:Pharyngectomy; D011183:Postoperative Complications / Q000517:prevention & control; D013060:Speech / Q000502:physiology