title: Cisplatin-induced imbalances in the pattern of chimeric marker gene expression in HeLa cells.
abstract: The effects of the antitumor drug cisplatin on gene expression have been measured during transient transfections in HeLa cells. The results indicate a surprising diversity of response. Expression from two promoters is strongly induced, both in non-replicating plasmids and cellular integrants, whereas expression from two other promoters is strongly inhibited. The results suggest that a drug-induced imbalance in gene expression may contribute to the antitumor properties of cisplatin.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles 90024.
authors.forename: G L
authors.initials: GL
authors.lastname: Evans
authors.forename: J D
authors.initials: JD
authors.lastname: Gralla
mesh_terms: D002678:Chimera; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics / Q000378:metabolism; D002945:Cisplatin / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D010957:Plasmids / Q000187:drug effects; D011401:Promoter Regions, Genetic / Q000187:drug effects*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D014162:Transfection
chemical_list: D011993:Recombinant Fusion Proteins; D015500:Chloramphenicol O-Acetyltransferase; D002945:Cisplatin