Folate supplements prevent recurrence of neural tube defects.
In a multicenter, randomized, double-blind intervention study, 4 mg of folate daily given around the time of conception significantly reduced the recurrence of neural tube defects. Supplementation with a folate-free multiple vitamin did not reduce the recurrence rate.
D005260:Female; D005492:Folic Acid / Q000627:therapeutic use*; D006801:Humans; D009436:Neural Tube Defects / Q000517:prevention & control*; D011247:Pregnancy; D012008:Recurrence
D005492:Folic Acid