title: Chronic granulomatous disease presenting with osteomyelitis: favorable response to treatment with interferon-gamma.
abstract: A 3-year-old boy with chronic granulomatous disease presented with abscesses related to underlying osteomyelitis. Treatment with appropriate antibiotics resulted in resistance of the organisms. Treatment with interferon-gamma was encouraging in that it caused the osteomyelitis to heal and prevented its relapse when used as long-term prophylaxis.
authors.affiliation: Department of Orthopaedic Surgery, University of Cape Town, Red Cross Children's Hospital, South Africa.
authors.forename: P J
authors.initials: PJ
authors.lastname: Gill
authors.forename: E
authors.initials: E
authors.lastname: Goddard
authors.forename: D W
authors.initials: DW
authors.lastname: Beatty
authors.forename: E B
authors.initials: EB
authors.lastname: Hoffman
mesh_terms: D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D008297:Male; D010019:Osteomyelitis / Q000150:complications* / Q000628:therapy; D011994:Recombinant Proteins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D007371:Interferon-gamma