title: Ischaemic heart disease and consumption of hydrogenated marine oils in England and Wales.
abstract: OBJECTIVE
  The aim was to examine the hypothesis that hydrogenated fats, particularly those obtained from marine oils, may present a health hazard.
  
  
  METHODS
  Storage fat specimens obtained at necropsy were collected from several areas in England and Wales during 1975-1978. Cases (n = 136 samples) consisted of males dying of ischaemic heart disease, male deaths from unrelated causes acting as controls (n = 95 samples). The fatty acid compositions of the specimens were determined, and analysis included those acids--16:1 trans and "higher" C-20 plus C-22 (H)--highly characteristic of partially hydrogenated marine oils.
  
  
  RESULTS
  The case samples, which had been shown to be the richer in 16:1 trans (p less than 0.005), were now found to have a significantly higher value of the ratio 16:1 trans to H (p less than 0.002), arising from consumption of differing hydrogenated marine oil types.
  
  
  CONCLUSIONS
  It is concluded that the cases had consumed a greater amount (p less than 0.001) of hydrogenated marine oils of a certain type, ie, that manufactured from certain highly unsaturated raw oils. The process of partial hydrogenation results in conversion to a product containing large amounts of polyunsaturated acids (PUFA) which are no longer in the natural all-cis methylene interrupted configuration. Such isomeric PUFA may obstruct or compete with utilisation of natural PUFA. It is further concluded that the case excess did not rise from medical advice favouring margarine or from any difference in social class status, but rather from fortuitous selection of margarine brand.
authors.affiliation: Department of Science and Chemical Engineering, Polytechnic of Wales, Pontypridd, Mid-Glamorgan, United Kingdom.
authors.forename: L H
authors.initials: LH
authors.lastname: Thomas
mesh_terms: D003327:Coronary Disease / Q000453:epidemiology / Q000517:prevention & control*; D004739:England / Q000453:epidemiology; D005224:Fats, Unsaturated / Q000008:administration & dosage*; D005227:Fatty Acids / Q000032:analysis; D005395:Fish Oils / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008383:Margarine; D012923:Social Class; D014852:Wales / Q000453:epidemiology
chemical_list: D005224:Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils; D008383:Margarine