title: Formation of biologically active 13,14-dihydro-prostaglandin E1 during intravenous infusion of prostaglandin E1 in newborns with ductus arteriosus-dependent congenital heart disease.
abstract: Plasma concentrations of prostaglandin (PG) E1 (12-150, median 25 pg ml-1) and 13,14-dihydro-PGE1 (3-62, median 45.5 pg ml-1) were measured by gas chromatography-mass spectrometry in eight newborns with ductus arteriosus-dependent congenital heart disease during continuous intravenous infusion of PGE1. Formation of 13,14-dihydro-PGE1 was demonstrated for the first time in neonates. Since 13,14-dihydro-PGE1 has similar biological activities as the parent compound PGE1, pharmacological effects during PGE1 infusion are most likely related to both PGE1 and the generation and action of 13,14-dihydro-PGE1.
authors.affiliation: Department of Paediatrics, University of Marburg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Leonhardt
authors.forename: H
authors.initials: H
authors.lastname: Schweer
authors.forename: D
authors.initials: D
authors.lastname: Wolf
authors.forename: H W
authors.initials: HW
authors.lastname: Seyberth
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000097:blood; D004374:Ductus Arteriosus, Patent / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn
chemical_list: C069881:13,14-dihydroprostaglandin E1; D000527:Alprostadil