title: Stroke topography and outcome in relation to hyperglycaemia and diabetes.
abstract: In a prospective study to analyse stroke topography and outcome in diabetics and to determine the prognostic value of blood glucose and glycosylated haemoglobin estimation, we evaluated 176 patients with acute stroke. The patients were classified into four groups on the basis of history, fasting glucose, and glycosylated haemoglobin: euglycaemic patients with no history of diabetes, stress hyperglycaemia, newly diagnosed diabetics, and known diabetics. A high prevalence of undiagnosed diabetes was shown. No difference was found in the type or site of stroke between the four groups. No difference was found in the site of symptomatic or incidental lesions on computerised axial tomography. Patients with stress hyperglycaemia and known diabetics had more severe strokes. Mortality was higher in patients with stress hyperglycaemia, newly diagnosed diabetics, and the combined diabetes groups. This increased mortality was evident in the hyperglycaemic and diabetic groups, even after excluding patients with cerebral haemorrhage. Stroke severity and mortality also increased independently with blood glucose in the euglycaemic group. We conclude that there is a correlation between admission glucose concentration, diabetes, and poor stroke outcome, which may not be attributed to stroke type or location.
authors.affiliation: Department of Neurology, Royal Melbourne Hospital, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Kiers
authors.forename: S M
authors.initials: SM
authors.lastname: Davis
authors.forename: R
authors.initials: R
authors.lastname: Larkins
authors.forename: J
authors.initials: J
authors.lastname: Hopper
authors.forename: B
authors.initials: B
authors.lastname: Tress
authors.forename: S C
authors.initials: SC
authors.lastname: Rossiter
authors.forename: J
authors.initials: J
authors.lastname: Carlin
authors.forename: S
authors.initials: S
authors.lastname: Ratnaike
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001931:Brain Mapping; D002543:Cerebral Hemorrhage / Q000097:blood / Q000175:diagnosis / Q000401:mortality; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis / Q000401:mortality; D002561:Cerebrovascular Disorders / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D003925:Diabetic Angiopathies / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011446:Prospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin