title: [Cryptococcosis: presentation of 26 cases].
abstract: BACKGROUND
  Cryptococcosis is more frequently observed since the appearance of the acquired immunodeficiency syndrome (AIDS). AIDS has modified the clinical and evolutive forms of the disease. This study reviews the changes produced in the infection from the context of AIDS.
  
  
  METHODS
  The present is a retrospective study (1985-1990) including patients presenting: 1) a positive latex agglutination test (serum or spinal fluid) or 2) a Sabouraud culture positive for cryptococcus. Clinical histories were revised collecting clinical, radiologic, analytic, therapeutic and evolutive data.
  
  
  RESULTS
  Twenty-six patients (21 males) were included in the study. Twenty patients had the human immunodeficiency virus. The clinical picture was: 22 cases with cryptococcal meningitis (13 with hematogenous participation), 3 with pulmonary cryptococcosis and one with disseminated cryptococcosis without meningeal involvement. The patients with AIDS had: greater frequency of positive hemocultures, higher serologic titers and fewer with the meningeal syndrome. The number of T4 lymphocytes was lower than 150 elements/ml in AIDS patients. In 17 patients treatment with amphotericin B and 5-fluorocytosine was administered, 5 received amphotericin B and two fluconazole and two did not receive the above since they had not been diagnosed alive. There were 6 deaths and 10 relapses in 6 AIDS patients and none in the remaining patients.
  
  
  CONCLUSIONS
  The incidence of cryptococcosis has increased as a consequence of AIDS. In these patients the disease occurs in advanced stages of immunodeficiency and frequently in disseminated, severe and paucisymptomatic forms. Treatment is usually effective although a maintenance therapy is required to avoid relapse.
authors.affiliation: Servico de Enfermedades Infecciosas, Hospital Clínic i Provincial, Barcelona.
authors.forename: E
authors.initials: E
authors.lastname: Pedrol
authors.forename: J
authors.initials: J
authors.lastname: Mallolas
authors.forename: J M
authors.initials: JM
authors.lastname: González-Clemente
authors.forename: J M
authors.initials: JM
authors.lastname: Miró
authors.forename: A
authors.initials: A
authors.lastname: Azón
authors.forename: J M
authors.initials: JM
authors.lastname: Gatell
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: J
authors.initials: J
authors.lastname: Mensa
authors.forename: E
authors.initials: E
authors.lastname: Soriano
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000150:complications*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000032:analysis; D003453:Cryptococcosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D003454:Cryptococcus / Q000302:isolation & purification; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D012189:Retrospective Studies
chemical_list: D000946:Antigens, Fungal; D000666:Amphotericin B; D005437:Flucytosine
vernacular_title: Criptococosis: presentación de 26 casos.