Structures of americanol A and isoamericanol A having a neurotrophic property from the seeds of Phytolacca americana.
The structures of new neo-lignans, isoamericanol A (1) and americanol A (2) isolated from the seeds of Phytolacca americana have been elucidated on the basis of spectroscopic data and then confirmed by chemical correlation with the previously known isoamericanin A (3) and americanin A (4). Isoamericanol A, americanol A, and americanin A have been found to enhance choline acetyltransferase activity at 10(-5) M in a cultured neuronal cell system derived from fetal rat hemisphere.
Fukuyama
Y
Y
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Hasegawa
T
T
Toda
M
M
Kodama
M
M
Okazaki
H
H
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004146:Dioxanes / Q000032:analysis* / Q000494:pharmacology; D004789:Enzyme Activation; D005260:Female; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011247:Pregnancy; D051381:Rats
D004146:Dioxanes; C074373:americanol A; C074374:isoamericanol A; D002795:Choline O-Acetyltransferase