[The problem of the radiosensitivity of bone marrow cellular elements and assessments of the postradiation kinetics of myelopoiesis (an analysis based on data on the sequelae of the accident at the Chernobyl Atomic Electric Power Station].
On the basis of the data obtained from 61 cases of accidental exposure (0.1-12.5 Gy) at the Chernobyl A.P.S. the kinetics of acute radiation bone-marrow syndrome was analyzed and radiosensitivity of the entire spectrum of human granulocytic compartment cells was estimated. The radiosensitivity estimates were made by a "functional" criterion, developed by the authors, which was based on the comparative ability of irradiated and nonirradiated bone marrow cells of different maturity to produce peripheral blood neutrophils. Changes were found in physiology of myeloid cells during their maturation: the maturation mechanism, for cells of the committed pool, was "attached" to the division process, whereas these processes were independent for cells of the dividing and maturing pool. It is once again confirmed that the transit time of a maturing myeloid cell, to begin with the primarily committed one and to end with a peripheral blood neutrophil, is not constant and lasts normally for 32 days.
Gruzdev
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GP
Chistopol'skiĭ
A S
AS
D000059:Accidents; D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology / Q000528:radiation effects*; D002455:Cell Division / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006410:Hematopoiesis / Q000528:radiation effects*; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000528:radiation effects; D006801:Humans; D007958:Leukocyte Count / Q000528:radiation effects; D009504:Neutrophils / Q000473:pathology / Q000528:radiation effects; D009688:Nuclear Reactors; D011210:Power Plants; D011832:Radiation Injuries / Q000097:blood; D011836:Radiation Tolerance; D013997:Time Factors; D014455:Ukraine
Problema radiochuvstvitel'nosti kletochnykh élementov kostnogo mozga i nekotorye otsenki postradiatsionnoĭ kinetiki mielopoéza (analiz po dannym posledstviĭ avarii na ChAES).