Sex differences in adrenal and hepatic alpha-tocopherol concentrations in rats.
Studies were done to determine whether there were differences in adrenal or hepatic concentrations of alpha-tocopherol in male versus female rats. alpha-Tocopherol levels were far greater in adrenal glands and livers from females than from males. There was no sex difference in the subcellular distribution of alpha-tocopherol in either organ, but alpha-tocopherol concentrations were generally greater in all subcellular fractions from females. Mitochondrial fractions contained approximately 50% of the total adrenal and hepatic alpha-tocopherol content. The results suggest that alpha-tocopherol concentrations in rat adrenals and livers are controlled, at least partly, by the gonadal hormones.
Feingold
I B
IB
Department of Pharmacology and Toxicology, Philadelphia College of Pharmacy and Science 19104.
Colby
H D
HD
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013347:Subcellular Fractions / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism*
D012739:Gonadal Steroid Hormones; D014810:Vitamin E