A behavior profile of the MRL/Mp lpr/lpr mouse and its association with hydrocephalus.
Since the NZB and BXSB autoimmune mouse strains have cortical ectopias and associated behavioral changes, mice from the MRL/l (MRL/Mp lpr/lpr) autoimmune strain were given a series of behavioral tests followed by anatomical analyses of their brains and immune assays of plasma. No cortical ectopias were found, but this strain was discovered to have a high incidence of hydrocephalus: 46% had severe dilatation of the lateral and third ventricles, 30% had moderate dilatation, and 24% had minimal or no enlargement of the ventricles (total N = 57). Those mice in the severe hydrocephalus group were poorer in a nonspatial discrimination learning task, had less paw asymmetry, and were less active in a swimming task. No association was found between degree of hydrocephalus and any immune parameter.
Denenberg
V H
VH
Biobehavioral Sciences Graduate Degree Program, University of Connecticut, Storrs 06269-4154.
Sherman
G F
GF
Rosen
G D
GD
Morrison
L
L
Behan
P O
PO
Galaburda
A M
AM
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis; D001327:Autoimmune Diseases / Q000235:genetics / Q000523:psychology*; D001522:Behavior, Animal / Q000502:physiology*; D003167:Complement Activation; D004924:Escape Reaction / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006849:Hydrocephalus / Q000235:genetics / Q000523:psychology*; D007136:Immunoglobulins / Q000032:analysis; D008232:Lymphoproliferative Disorders / Q000235:genetics; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology / Q000523:psychology*; D009043:Motor Activity / Q000502:physiology; D012737:Sex Factors; D013037:Spatial Behavior
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins