Kindling and its consequences on learning in rats.
To study the learning performance of pentylenetetrazol- and amygdala-kindled Wistar rats we used the following learning tests: short-term memory was tested in the response-to-change model, brightness discrimination was tested in a Y-chamber, and two-way active avoidance learning was tested in a shuttle-box. Short-term memory was not impaired by both kindling procedures. Considering two-way active avoidance learning the performance of pentylenetetrazol (PTZ)-kindled rats was significantly diminished. This effect persists over a period of 4 weeks. However, amygdala (AMY)-kindled rats acquired this task like the controls. In brightness discrimination reaction (BDR) the learning performance of PTZ-kindled animals was not influenced. Although the acquisition of BDR was nearly identical, the 24-h retention was remarkably diminished in AMY-kindled rats. It was hypothesized that the different kindling procedures interfere in different ways and extent with neuronal circuits resulting in different functional impairments.
Becker
A
A
Medical Academy Magdeburg, Institute of Pharmacology and Toxicology, Germany.
Grecksch
G
G
Rüthrich
H L
HL
Pohle
W
W
Marx
B
B
Matthies
H
H
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001288:Attention / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology*; D001931:Brain Mapping; D004193:Discrimination Learning / Q000502:physiology*; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D010433:Pentylenetetrazole; D051381:Rats; D011919:Rats, Inbred Strains; D012153:Retention, Psychology / Q000502:physiology*
D010433:Pentylenetetrazole