title: The kinetics of copper-62-PTSM in the normal human heart.
abstract: Copper-62-labeled pyruvaldehyde bis(N-4-methylthiosemicarbazone) copper(II) (PTSM) is a generator-produced myocardial perfusion tracer. Animal studies have shown high myocardial tissue extraction and prolonged retention. The aim of this study was to define myocardial kinetics of 62Cu-PTSM and to determine its suitability for evaluating myocardial perfusion at rest and during pharmacological vasodilation in human subjects. In six healthy volunteers, 62Cu-PTSM was administered at baseline and during a 6-min adenosine infusion (140 micrograms/kg/min). Dynamic PET imaging with high temporal resolution was performed over 20 min. Good image quality was observed at rest and following adenosine. Myocardial kinetics demonstrated prolonged tissue retention with a clearance half-life of 105 +/- 49 min at rest and 101 +/- 65 min following adenosine (p = ns). Copper-62-PTSM tissue retention was quantified and showed only a 1.97-fold increase from rest to adenosine studies. This suggests attenuation of tracer retention at high flow rates. Copper-62-PTSM represents a promising new radiopharmaceutical for the evaluation of myocardial perfusion in the human heart.
authors.affiliation: Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0028.
authors.forename: R S
authors.initials: RS
authors.lastname: Beanlands
authors.forename: O
authors.initials: O
authors.lastname: Muzik
authors.forename: M
authors.initials: M
authors.lastname: Mintun
authors.forename: T
authors.initials: T
authors.lastname: Mangner
authors.forename: K
authors.initials: K
authors.lastname: Lee
authors.forename: N
authors.initials: N
authors.lastname: Petry
authors.forename: G D
authors.initials: GD
authors.lastname: Hutchins
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
mesh_terms: D000241:Adenosine; D000328:Adult; D003300:Copper; D003301:Copper Radioisotopes; D003327:Coronary Disease / Q000000981:diagnostic imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; C063293:copper (II) pyruvaldehyde bis(N(4)-dimethylthiosemicarbazone); D003300:Copper; D000241:Adenosine