Preparation and in vitro and in vivo evaluation of quinolones with selective activity against gram-positive organisms.
A series of quinolones were prepared which contained oximes or substituted oximes as replacements for the amine substituents normally found on the pyrrolidine or piperidine fragments of quinolone antibacterial agents. These substituents led to compounds that had selective activity against Gram-positive organisms. These compounds showed in vivo activity against Staphylococcus aureus. Only compound 29 had in vivo activity against Streptococcus pneumoniae.
Cooper
C S
CS
Anti-infective Research Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500.
Klock
P L
PL
Chu
D T
DT
Hardy
D J
DJ
Swanson
R N
RN
Plattner
J J
JJ
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D042462:4-Quinolones; D000890:Anti-Infective Agents