title: Monoclonal large granular lymphocyte proliferation in SLE with HTLV-I seroreactivity.
abstract: A 60-year-old part Aboriginal woman was observed to develop severe neutropenia and a large granular lymphocyte (LGL) proliferation five years after the diagnosis of systemic lupus erythematosus (SLE). Monoclonality of the CD3+, CD4-, CD8+ LGL population was confirmed using the novel approach of X-linked restriction fragment length polymorphism (RFLP) analysis. Indeterminate HTLV-I serology was present. The patient responded to steroid therapy. LGL proliferation in the setting of SLE and the use of X-linked RFLP analysis to define LGL clonality have not previously been reported.
authors.affiliation: Mater Misericordiae Hospitals, Brisbane, Qld., Australia.
authors.forename: P
authors.initials: P
authors.lastname: Marlton
authors.forename: K
authors.initials: K
authors.lastname: Taylor
authors.forename: S
authors.initials: S
authors.lastname: Elliott
authors.forename: J
authors.initials: J
authors.lastname: McCormack
mesh_terms: D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis*; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008875:Middle Aged
chemical_list: D000911:Antibodies, Monoclonal