A protein which specifically binds to single stranded TTAGGGn repeats.
Nuclei from tissues of many vertebrates contain a soluble 37 kd protein which binds with a high degree of specificity to oligonucleotides which contain the G rich strand of the telomeric terminal repeats, TTAGGG. In some tissues this is an abundant nuclear protein.
McKay
S J
SJ
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK.
Cooke
H
H
D000818:Animals; D001483:Base Sequence; D004277:DNA, Single-Stranded / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000302:isolation & purification / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D051379:Mice; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D013045:Species Specificity; D016615:Telomere / Q000378:metabolism
D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins