[Measurement of small bowel transit time in dogs with acetaminophen and indocyanine green].
We developed an experimental method to measure the gastric and the small bowel transit times in dogs without using X-ray nor radioisotopes. The dog with the ileostomy was given food containing acetaminophen (APAP) and indocyanine green (ICG), then we sampled blood and ileal contents of the dog. We could measure the gastric transit time by detecting plasma APAP and the small bowel transit time by detecting ICG in the intestinal contents. Using this experimental system, we examined the times after feeding milk or solid meal. The gastric transit time after taking solid meal was longer than that after taking milk, but this difference was not significant, and the small bowel transit time after taking solid meal was significantly shorter than that after taking milk.
Yamaki
K
K
First Department of Surgery, Faculty of Medicine, Kyoto University.
Manabe
T
T
Yamamoto
M
M
Tobe
T
T
Kobayashi
Y
Y
Mitani
T
T
Kurono
M
M
D000082:Acetaminophen; D000818:Animals; D004285:Dogs; D005772:Gastrointestinal Transit; D007208:Indocyanine Green; D007421:Intestine, Small / Q000502:physiology*
D000082:Acetaminophen; D007208:Indocyanine Green