[Chromosomic etiology of male sterility and infertility].
Recent advances in the knowledge of sexual development have been obtained by studying individuals with dysgenetic gonads and reproductive tract alterations. By using probes Y-ADN in these patients, it was found that a gene of the short arms of Y chromosome, induces testicular differentiation. The way this gene acts is not known, but the observation that there are homologue sequencies in X and Y, suggests the possibility that sexual differentiation depends on genic doses. Other genes like the one that codifies for antigen H-Y, for skeletal maturation, body growth, dental size and spermatogenesis regulation, have been identified in chromosome Y. Findings that have allowed a better understanding of genetic and cytogenetic factor involved in sterility-infertility.
Vega Hernández
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ME
Departamento de Genética, Hospital General Centro Médico La Raza, IMSS, D.F.
Pedrón Nuevo
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N
Márquez Orozco
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MC
D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D012733:Sex Differentiation; D013091:Spermatogenesis; D014998:Y Chromosome
Etiología cromosómica de la esterilidad e infertilidad masculina.