T lymphocyte dependent enteropathy in murine Trichinella spiralis infection.
Mice infected with Trichinella spiralis developed significant enteropathy, comprising villus atrophy, crypt hyperplasia, goblet cell hyperplasia and a decrease in intra-epithelial lymphocyte numbers by 10 days post-infection, when most of the parasites had been expelled from the gut. However, worm expulsion was prevented by treatment with cyclosporin A and, despite a continued parasite burden, cyclosporin A treated animals had no villus atrophy or changes in inflammatory cell numbers. These results confirm that the expulsion of T. spiralis from the mouse gut is accompanied by a significant intestinal lesion and that both of these phenomena are T-cell mediated.
Garside
P
P
Immunology Department, University of Glasgow, Western Infirmary.
Grencis
R K
RK
Mowat
A M
AM
D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use; D004751:Enteritis / Q000188:drug therapy / Q000469:parasitology / Q000473:pathology; D006965:Hyperplasia; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000469:parasitology / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D010270:Parasite Egg Count; D013601:T-Lymphocytes / Q000276:immunology*; D014235:Trichinellosis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
D016572:Cyclosporine