title: Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.
abstract: Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J/A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.
authors.affiliation: Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030.
authors.forename: C J
authors.initials: CJ
authors.lastname: Faust
authors.forename: A J
authors.initials: AJ
authors.lastname: Verkerk
authors.forename: P J
authors.initials: PJ
authors.lastname: Wilson
authors.forename: C P
authors.initials: CP
authors.lastname: Morris
authors.forename: J J
authors.initials: JJ
authors.lastname: Hopwood
authors.forename: B A
authors.initials: BA
authors.lastname: Oostra
authors.forename: G E
authors.initials: GE
authors.lastname: Herman
mesh_terms: D000818:Animals; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D016532:Mucopolysaccharidosis II / Q000235:genetics*; D011995:Recombination, Genetic; D013045:Species Specificity; D014960:X Chromosome
chemical_list: D004247:DNA