The geography of non-ocular malignant melanoma in India: its association with latitude, ozone levels and UV light exposure.
Ultraviolet light from sunlight is implicated in the aetiology of non-ocular malignant melanoma, mostly from Western studies. This study reports the relation of such melanomas from 7 cancer registries in different parts of India with latitude, altitude, ozone levels and ultraviolet (UV) light exposure. A log linear model was fitted using GLIM, assuming Poisson errors in incidence; linear and non-linear regression techniques were also used. Results show slight negative associations of melanoma with latitude, chi 2 = -3.37, p = 0.07, and statistically non-significant ones with atmospheric ozone levels (r = -0.36, n.s.), and a positive association with UV (r = 0.30, n.s.). Melanoma incidence from 4 places relates in a parabolic curve with latitude (y = 1-0.09 chi 2 + 0.003 chi 2 in males and y = 1.73-0.17 chi 2 + 0.005 chi 2 in females). Patients originally from west coastal ethnic/linguistic communities predominate in Bombay. Geographic patterns of melanoma in Indians are similar with those in white Caucasians. Ultraviolet light exposure may also be involved in its aetiology in non-white Caucasians, such as Indians.
Krishnamurthy
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National Cancer Registry Project, Indian Council of Medical Research, Tata Memorial Hospital Annexe, Parel, Bombay.
D001272:Atmosphere; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008545:Melanoma / Q000453:epidemiology* / Q000209:etiology; D010126:Ozone; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology; D013472:Sunlight / Q000009:adverse effects; D014466:Ultraviolet Rays / Q000009:adverse effects
D010126:Ozone