Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.
Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J/A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.
Faust
C J
CJ
Institute for Molecular Genetics, Baylor College of Medicine, Houston, TX 77030.
Verkerk
A J
AJ
Wilson
P J
PJ
Morris
C P
CP
Hopwood
J J
JJ
Oostra
B A
BA
Herman
G E
GE
D000818:Animals; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D016532:Mucopolysaccharidosis II / Q000235:genetics*; D011995:Recombination, Genetic; D013045:Species Specificity; D014960:X Chromosome
D004247:DNA