Failure of interleukin-2 to alter systolic blood pressure in Dahl salt-sensitive rats.
The effect of interleukin-2 (IL-2) on systolic blood pressure in Dahl salt-sensitive rats was investigated. The treatment group received human IL-2 injections (5000 units/kg). Control animals received subcutaneous saline injections. Both groups of animals were placed on a diet containing 1.5% sodium the day of the first injection and maintained on that diet for the duration of the study. Systolic blood pressure increased in both the IL-2 treated and the control groups (P = .0001) over 7 weeks. The increase in SBP was the same for both groups (P = .8823 for between group differences). At the end of 7 weeks, when SBP in both groups was elevated to a similar degree, the IL-2 group and the control group were each administered 5000 units/kg of IL-2. SBP in both groups remained elevated, showing no decrease over the next two weeks. These results indicate that perhaps unlike in SHR, IL-2 does not alter systolic blood pressure in Dahl salt-sensitive rats.
Given
M B
MB
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Lowe
R F
RF
Williams
D L
DL
Sander
G E
GE
Giles
T D
TD
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D004342:Drug Hypersensitivity / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control; D007279:Injections, Subcutaneous; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D013599:Systole / Q000187:drug effects / Q000502:physiology
D007376:Interleukin-2; D012965:Sodium Chloride