The multimeric pattern of von Willebrand's factor (vWF) can be demonstrated also in the severe form of the disease.
The multimeric analysis was carried out on the plasma of 18 patients with severe von Willebrand's disease (vWD) using two different types of agarose: Seakem HGT(P) and Seaplaque LGT. No pattern was found in any of the patients using Seakem HGT(P). On the contrary, by Seaplaque LGT, a multimeric pattern was found in four patients belonging to three different families, indicating that it is possible to identify and characterize variable multimeric patterns also in type III vWD.
Pezzetti
L
L
Department of Haematology, Ospedale Niguarda Cà Granda, Milano, Italy.
Redaelli
R
R
Caimi
T M
TM
Cattaneo
D
D
Baudo
F
F
De Cataldo
F
F
D001704:Biopolymers; D006801:Humans; D014842:von Willebrand Diseases / Q000097:blood*; D014841:von Willebrand Factor / Q000737:chemistry*
D001704:Biopolymers; D014841:von Willebrand Factor