[Significance of oncogenes and growth factors in hypernephroma].
In all cells there are a number of genes that regulate cell division and growth. In an "activated" form they are called oncogenes and play a role in the carcinogenesis. The activation results from such alterations as point mutation and translocation or alterations with increased synthesis of genes and gene product. There are different oncogene families. Up to now only a small number have been tested in renal cancer cells.
Peter
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Urologische Klinik und Poliklinik, Heinrich-Heine Universität Düsseldorf.
D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000503:physiopathology; D003062:Codon; D004273:DNA, Neoplasm / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation / Q000235:genetics; D009857:Oncogenes / Q000235:genetics*; D016133:Polymerase Chain Reaction; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics; D014158:Transcription, Genetic / Q000235:genetics
D003062:Codon; D004273:DNA, Neoplasm; D006133:Growth Substances; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
Bedeutung von Onkogenen und Wachstumsfaktoren bei Hypernephrom.