title: Metabolic products of microorganisms. 263. Nikkomycins SZ, SX, SoZ and SoX, new intermediates associated to the nikkomycin biosynthesis of Streptomyces tendae.
abstract: New intermediates associated with nikkomycin biosynthesis, called nikkomycins SZ, SX, SoZ and SoX, were isolated and characterized from the culture broth of Streptomyces tendae Tü 901/S 2566. They are analogues to octosyl acids, shunt metabolites of polyoxin biosynthesis. The decreasing amounts of nikkomycins SZ and SX, produced in the culture medium, shows a significant correlation to the increasing amounts of the biologically active nikkomycins Z and X, dependent on the increasing concentration of iron.
authors.affiliation: Biologisches Institut, LB Mikrobiologie/Antibiotika, Universität Tübingen, Germany.
authors.forename: T C
authors.initials: TC
authors.lastname: Schüz
authors.forename: H P
authors.initials: HP
authors.lastname: Fiedler
authors.forename: H
authors.initials: H
authors.lastname: Zähner
authors.forename: M
authors.initials: M
authors.lastname: Rieck
authors.forename: W A
authors.initials: WA
authors.lastname: Konig
mesh_terms: D000617:Aminoglycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism*; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D007093:Imidazoles; C073933:nikkomycin So(Z); C073931:nikkomycin S(X); C073932:nikkomycin So(X); C073930:nikkomycin S(Z); D014498:Uracil