title: Significance of phototherapy-induced riboflavin deficiency in the full-term neonate.
abstract: As a result of impaired fatty acid oxidation, a characteristic urinary dicarboxylic aciduria occurs in the riboflavin deficient animal. We compared the occurrence of riboflavin deficiency induced by phototherapy with changes in urinary organic acid profiles in 8 full-term, breast-fed neonates who received phototherapy for hyperbilirubinemia, and in 10 full-term, breastfed controls. Riboflavin status was assessed by measuring flavin adenine dinucleotide saturation of erythrocyte glutathione reductase. All 8 neonates exposed to phototherapy developed riboflavin deficiency (p less than 0.001). Riboflavin deficiency was progressive with the duration of phototherapy. None of the controls was riboflavin deficient. Urine organic acid profiles indicative of mitochondrial acyl-CoA dehydrogenase activity (fatty acid beta-oxidation, quantitated by gas chromatography mass spectrometry) showed no changes between the study and control groups in mono-, di-, or tricarboxylic acids or other organic acids. The riboflavin deficiency induced by phototherapy in full-term neonates was not of sufficient severity to limit riboflavin-dependent fatty acid oxidation.
authors.affiliation: Foothills Hospital, Calgary, Canada.
authors.forename: H J
authors.initials: HJ
authors.lastname: Amin
authors.forename: A K
authors.initials: AK
authors.lastname: Shukla
authors.forename: F
authors.initials: F
authors.lastname: Snyder
authors.forename: E
authors.initials: E
authors.lastname: Fung
authors.forename: N M
authors.initials: NM
authors.lastname: Anderson
authors.forename: H G
authors.initials: HG
authors.lastname: Parsons
mesh_terms: D001724:Birth Weight; D001942:Breast Feeding; D005865:Gestational Age; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D007231:Infant, Newborn; D010789:Phototherapy / Q000009:adverse effects*; D012257:Riboflavin Deficiency / Q000097:blood / Q000209:etiology* / Q000503:physiopathology