Arthritis in patients with psoriasis treated with gamma-interferon.
We observed 3 patients with psoriasis who developed arthritis during treatment of psoriatic skin disease with intramuscular recombinant human gamma-interferon (IFN-gamma). Symptoms primarily involved the hands, feet, shoulders, and neck. One patient had acute plantar fasciitis. Routine laboratory studies were unrevealing. Patients presented with symptoms initially between the 10th and 12th weeks of treatment and the arthritis resolved after cessation of IFN-gamma. One patient was subsequently retreated with IFN-gamma for 4 weeks and had a temporary recurrence of arthritis with an associated rise and fall of his articular index.
O'Connell
P G
PG
Department of Rehabilitation Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Gerber
L H
LH
Digiovanna
J J
JJ
Peck
G L
GL
D000328:Adult; D015535:Arthritis, Psoriatic / Q000139:chemically induced*; D002986:Clinical Trials as Topic; D006801:Humans; D007273:Injections, Intramuscular; D007371:Interferon-gamma / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy
D007371:Interferon-gamma