title: Ultrastructure of electrical synapses: review.
abstract: This article reviews studies providing information on the ultrastructure of electrical synapses. Although the review focuses on electron-microscopic investigations, its aim is to examine how the structure of an electrical synapse relates to its function. It begins by presenting a historical overview of the early studies which were responsible for the recognition of electrical synapses. The structure of gap junctions which are the morphological correlates of electrical synapses is illustrated and the ultrastructure and function of the two types of electrical synapse, rectifying and non-rectifying, described. Recent papers investigating the ultrastructure of electrical and mixed electrical-chemical synapses in invertebrates and vertebrates are reviewed. For earlier references, the reader is directed to previous reviews on the subject. Much new information, however, on the structure and formation of electrical synapses has been obtained from work on cultured neurons and from electron-microscopic, immunocytochemical, conformational and molecular studies. This article reviews those studies and in light of their findings, re-examines the relationships of the structure of electrical synapses with their function.
authors.affiliation: Department of Zoology, University of Cambridge, U.K.
authors.forename: B
authors.initials: B
authors.lastname: Leitch
mesh_terms: D000818:Animals; D008854:Microscopy, Electron; D013569:Synapses / Q000648:ultrastructure*