Stimulatory effects of islet amyloid polypeptide (amylin) on exocrine pancreas and gastrin release in conscious rats.
A rat islet amyloid polypeptide (amylin), 37-residue peptide amide was synthesized by the Fmoc-based solid phase method and the biological activity of synthetic rat amylin on exocrine pancreas was evaluated for the first time in conscious rat. Amylin (1, 10 nmol/kg/h) stimulated pancreatic exocrine secretion and plasma gastrin concentration. CR-1409, a CCK receptor antagonist, did not change amylin-stimulated pancreatic secretion. However, omeprazole (proton pump inhibitor) and atropine inhibited amylin-stimulated pancreatic secretion. This study suggests that amylin may play a role in biological action in the exocrine pancreas possibly mediated by gastric acid hypersecretion.
Funakoshi
A
A
National Kyushu Cancer Center, Fukuoka, Japan.
Miyasaka
K
K
Kitani
K
K
Nakamura
J
J
Funakoshi
S
S
Fukuda
H
H
Fujii
N
N
D000682:Amyloid / Q000502:physiology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001786:Blood Glucose / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009853:Omeprazole / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000682:Amyloid; D001786:Blood Glucose; D005755:Gastrins; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D001285:Atropine; D005934:Glucagon; D009853:Omeprazole