Chediak-Higashi syndrome in a black child.
Chediak-Higashi syndrome (CHS) is an uncommon genetic disorder with a constellation of clinical, pathologic, and immunologic manifestations. It is rarely reported in blacks. Pathognomonic intracellular inclusions in white blood cells are well recognized; however, characteristic abnormal melanin aggregation into giant melanosomes also occurs, as can be readily seen by histologic evaluation of hair. We present a case of CHS in a black child.
Anderson
L L
LL
Department of Medicine, Brooke Army Medical Center, Fort Sam Houston, Texas.
Paller
A S
AS
Malpass
D
D
Schmidt
M L
ML
Berger
T G
TG
D044383:Black People; D002609:Chediak-Higashi Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D014481:United States / Q000453:epidemiology; D001741:Black or African American