title: [A patient with liver cirrhosis manifesting various symptoms including cerebellar ataxia due to germanium intoxication].
abstract: A patient with hepatitis B virus-associated cirrhosis manifested various symptoms such as anemia, renal damage and neurological signs including cerebellar ataxia due to long-term administration of germanium-containing food. The patient was a 40-year-old male who had taken germanium containing mineral cheese for 26 months after he was diagnosed as having cirrhosis. Twenty four months after beginning to take the mineral cheese, he began manifesting paresthesia of the extremities, dysarthria and gait ataxia. Laboratory findings revealed anemia and renal damage. Biopsy of the peripheral nerve revealed loss of the large sheathed nerve, a characteristic feature of germanium intoxication. A high concentration of germanium (GeO2) was detected in patient's hair and urine. Cerebellar ataxia was characteristic in this patient, which was not reported in the previous papers.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka.
authors.forename: M
authors.initials: M
authors.lastname: Fujimoto
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi
authors.forename: R
authors.initials: R
authors.lastname: Shimamura
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
authors.forename: J
authors.initials: J
authors.lastname: Kudo
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
authors.forename: J
authors.initials: J
authors.lastname: Kira
authors.forename: K
authors.initials: K
authors.lastname: Miyata
mesh_terms: D000328:Adult; D002524:Cerebellar Ataxia / Q000139:chemically induced*; D002611:Cheese; D005527:Food, Fortified / Q000009:adverse effects*; D005857:Germanium / Q000009:adverse effects / Q000506:poisoning*; D006801:Humans; D008103:Liver Cirrhosis / Q000188:drug therapy*; D008297:Male
chemical_list: D005857:Germanium; C040516:germanium oxide