Mesalazine associated nephrogenic diabetes insipidus presenting as weight loss.
Nephrotoxicity in association with 5-aminosalicylic acid therapy is well recognised. In this patient the nephrotoxicity only became apparent after severe weight loss had occurred in association with nephrogenic diabetes insipidus. The patient aged 26 with ulcerative colitis received resin coated mesalazine (Asacol) 1200 mg/day and lost 12 kg in weight over a four month period, only complaining of thirst towards the end of this period.
Masson
E A
EA
Department of Medicine, University of Liverpool.
Rhodes
J M
JM
D000328:Adult; D000636:Aminosalicylic Acids / Q000009:adverse effects*; D003919:Diabetes Insipidus / Q000139:chemically induced*; D006801:Humans; D008297:Male; D019804:Mesalamine; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000503:physiopathology; D015431:Weight Loss / Q000502:physiology*
D000636:Aminosalicylic Acids; D019804:Mesalamine