title: CP-82,009, a potent polyether anticoccidial related to septamycin and produced by Actinomadura sp.
abstract: A new polyether antibiotic CP-82,009 (C49H84O17) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53676). Following purification by column chromatography and crystallization, the structure of CP-82,009 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-82,009 is among the most potent anticoccidial agents known, effectively controlling the Eimeria species that are the major causative agents of chicken coccidiosis at doses of 5 mg/kg or less in feed. It is also active in vitro against certain Gram-positive bacteria, as well as the spirochete, Serpulina (Treponema) hyodysenteriae.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, CT 06340.
authors.forename: J P
authors.initials: JP
authors.lastname: Dirlam
authors.forename: A M
authors.initials: AM
authors.lastname: Belton
authors.forename: J
authors.initials: J
authors.lastname: Bordner
authors.forename: W P
authors.initials: WP
authors.lastname: Cullen
authors.forename: L H
authors.initials: LH
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Nishiyama
authors.forename: J R
authors.initials: JR
authors.lastname: Oscarson
authors.forename: A P
authors.initials: AP
authors.lastname: Ricketts
mesh_terms: D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002645:Chickens; D003049:Coccidiostats / Q000302:isolation & purification* / Q000494:pharmacology; D004987:Ethers / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008968:Molecular Conformation; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D004987:Ethers; D011714:Pyrans; C074361:CP 82009; C011547:septamycin