Application of respiratory heat exchange for the measurement of lung water.
A noninvasive method for measuring pulmonary blood flow and lung mass (called airway thermal volume), based on the measurements of lung heat exchange with environment, is described. The lungs function as a steady-state heat exchange system, having an inner heat source (pulmonary blood flow) and an external heat sink (ventilation). Sudden changes in the steady-state condition, such as caused by hyperventilation of dry air, lead to a new steady state after a few minutes. The expired air temperature difference between the initial and final steady states is proportional to pulmonary blood flow, whereas the rate at which the new steady state is achieved is proportional to airway thermal volume. The method was tested in 20 isolated dogs lungs, 9 perfused goat lungs, and 27 anesthetized sheep. The expired air temperature fall during hyperventilation was inversely proportional to the perfusion rate of the isolated lungs, and half-time of the temperature fall was proportional to the lung tissue mass. Experiments in anesthetized sheep showed that the measured airway thermal volume is close to the total mass of the excised lungs, including its residual blood (r = 0.98). Pulmonary edema and fluid instillation into the bronchial tree increased in the measured lung mass.
Serikov
V B
VB
Cardiovascular Research Institute, University of California, San Francisco 94143.
Rumm
M S
MS
Kambara
K
K
Bootomo
M I
MI
Osmack
A R
AR
Staub
N C
NC
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D001834:Body Water / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006041:Goats; D066298:In Vitro Techniques; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D010477:Perfusion; D011652:Pulmonary Circulation / Q000502:physiology; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology; D012119:Respiration / Q000502:physiology; D012756:Sheep; D013990:Tidal Volume