title: Molecular characterization of a Drosophila melanogaster variant strain defective in the Sgs-4 gene dosage compensation.
abstract: The X-linked Sgs-4 gene of Drosophila melanogaster encodes a salivary glue protein. Here we report the molecular characterization of a non-dosage compensated variant strain, named Karsnas, in which males accumulate only about half of the Sgs-4 polypeptide amount as do females. The results obtained show that significant nucleotide sequence alterations are accumulated within the Sgs-4 coding and 3' untranslated region of the variant strain, thus suggesting a possible role of these sequences in the Sgs-4 dosage compensation.
authors.affiliation: Dipartimento di Genetica, Biologia Generale e Molecolare, Università di Napoli, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Furia
authors.forename: F A
authors.initials: FA
authors.lastname: Digilio
authors.forename: D
authors.initials: D
authors.lastname: Artiaco
authors.forename: G
authors.initials: G
authors.lastname: Favia
authors.forename: L C
authors.initials: LC
authors.lastname: Polito
mesh_terms: D000818:Animals; D001483:Base Sequence; D004303:Dosage Compensation, Genetic; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005967:Glue Proteins, Drosophila / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics
chemical_list: D005967:Glue Proteins, Drosophila