title: Clinical effects of long-term use of neutralized dialysate for continuous ambulatory peritoneal dialysis.
abstract: The long-term effects of neutralized dialysate used in continuous ambulatory peritoneal dialysis (CAPD) were evaluated in 8 well-controlled patients. Twelve milliliters of 8.4% sodium bicarbonate was added to Dianeal PD-1 immediately before every administration. The final pH was 6.8 and the concentration of sodium bicarbonate was 6 mmol/l. The final sodium level was 138 mEq/l. This dialysate was used for 5 months. For 2 months before and 3 months after this period, Dianeal PD-2 was used as the dialysate for comparison. Blood bicarbonate levels significantly improved during the use of the neutralized dialysate. Blood sodium, chloride and magnesium levels and the effluent volume significantly increased. Sodium balance improved during the period when neutralized dialysate was used. Total leukocyte counts in the effluent decreased, and leukocyte viability increased. Abdominal distention, abdominal pain during instillation, nausea and headache improved. No side effects, including peritonitis, occurred during the trial of neutralized dialysate. The results suggest that this dialysate was less irritating to the peritoneal membrane than the control dialysate and that the therapeutic effects were satisfactory.
authors.affiliation: Kidney Center, Shirasagi Hospital, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Sakakura
authors.forename: M
authors.initials: M
authors.lastname: Yamakawa
authors.forename: N
authors.initials: N
authors.lastname: Horiuchi
authors.forename: S
authors.initials: S
authors.lastname: Hirata
authors.forename: Y
authors.initials: Y
authors.lastname: Iritani
authors.forename: H
authors.initials: H
authors.lastname: Nishitani
authors.forename: M
authors.initials: M
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
authors.forename: T
authors.initials: T
authors.lastname: Chiku
mesh_terms: D001806:Blood Urea Nitrogen; D004573:Electrolytes / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007674:Kidney Diseases / Q000628:therapy*; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010538:Peritonitis / Q000209:etiology; D012996:Solutions
chemical_list: D004573:Electrolytes; D012996:Solutions