title: Changing patterns of glucose metabolism during the course of subacute sclerosing panencephalitis as measured with 18FDG-positron-emission tomography.
abstract: 18FDG-positron emission tomography performed at different stages in the course of subacute sclerosing panencephalitis revealed a changing pattern of metabolic disturbance. In clinical stage II patients the inflammation in the basal ganglia appeared to lead to neuronal excitation accompanied by hypermetabolism. Widespread cortical functional inhibition of metabolism followed. The striatal inflammation ended with necrosis and hypometabolism, with resulting functional cortical disinhibition; later, deep midbrain structures and brain stem became hypermetabolic. A patient clinically in remission showed no such changes in cerebral glucose metabolism.
authors.affiliation: Neurologische Universitätsklinik, Köln, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Huber
authors.forename: G
authors.initials: G
authors.lastname: Pawlik
authors.forename: S
authors.initials: S
authors.lastname: Bamborschke
authors.forename: G R
authors.initials: GR
authors.lastname: Fink
authors.forename: H
authors.initials: H
authors.lastname: Karbe
authors.forename: M
authors.initials: M
authors.lastname: Schlenker
authors.forename: H
authors.initials: H
authors.lastname: Bewermeyer
authors.forename: W D
authors.initials: WD
authors.lastname: Heiss
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000276:immunology; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004569:Electroencephalography; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008459:Measles virus / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000000981:diagnostic imaging / Q000276:immunology / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D000914:Antibodies, Viral; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose