title: Bilirubin uridine diphosphate glucuronosyltransferase hepatic activity in jaundice associated with congenital hypothyroidism.
abstract: Hepatic bilirubin uridine diphosphate glucuronosyltransferase activity was assayed in an infant with prolonged jaundice and congenital hypothyroidism before thyroid therapy. This activity was nil, suggesting a possible delayed maturation of the enzyme. Although further studies will be necessary to confirm this hypothesis, prolonged jaundice associated with congenital hypothyroidism may be due to a delayed maturation of the hepatic glucuronidation of bilirubin.
authors.affiliation: Service de Pédiatrie, Hôpital Antoine Béclère, Clamart, France.
authors.forename: P
authors.initials: P
authors.lastname: Labrune
authors.forename: A
authors.initials: A
authors.lastname: Myara
authors.forename: P
authors.initials: P
authors.lastname: Huguet
authors.forename: A
authors.initials: A
authors.lastname: Folliot
authors.forename: M
authors.initials: M
authors.lastname: Vial
authors.forename: F
authors.initials: F
authors.lastname: Trivin
authors.forename: M
authors.initials: M
authors.lastname: Odievre
mesh_terms: D001663:Bilirubin / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D003409:Congenital Hypothyroidism; D005260:Female; D014453:Glucuronosyltransferase; D006602:Hexosyltransferases / Q000378:metabolism*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000378:metabolism*; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000209:etiology / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*
chemical_list: C019787:bilirubin glucuronoside glucuronosyltransferase; D006602:Hexosyltransferases; D014453:Glucuronosyltransferase; D001663:Bilirubin