title: [Predictive factors of response to chemotherapy in epidermoid cancer of the esophagus. Study apropos of 60 patients and evaluation of a response score].
abstract: The aim of this study was to select predictive factors for response to chemotherapy in esophageal squamous cell carcinoma. Sixty patients, aged between 39 and 77 years (mean 61.5) received two initial chemotherapy sessions of 5 FU (1 mg/m2/24 h) and cisplatinum (20 mg/m2/24 h) during four days. Sixteen clinical, endoscopic, biological, and histological factors were collected. The response to chemotherapy was evaluated one month after completion of the second session by means of endoscopic and computed tomographic data. Thirty-two percent (CI: 20-44 percent) of patients had an objective response to chemotherapy (according to WHO criteria). Univariate analysis showed two predictive factors: obstructing pattern of tumor (P less than 0.01) and albuminemia less than 35 g/l (P less than 0.01). A response score was calculated with a stepwise regression model. The score correctly predicted a satisfactory response to chemotherapy with a sensitivity and specificity of 84.2 and 73 percent, respectively. Overall survival of these patients was statistically higher (P less than 0.001) compared with patients without any response. A satisfactory response to chemotherapy in patients with esophageal squamous cell carcinoma can be expected according to certain pretreatment factors.
authors.affiliation: Service d'Hépato-Gastroentérologie, CHRU d'Angers.
authors.forename: T
authors.initials: T
authors.lastname: Charlois
authors.forename: P
authors.initials: P
authors.lastname: Burtin
authors.forename: A K
authors.initials: AK
authors.lastname: Ben Bouali
authors.forename: B
authors.initials: B
authors.lastname: Person
authors.forename: P
authors.initials: P
authors.lastname: Ferrero
authors.forename: J
authors.initials: J
authors.lastname: Delaby
authors.forename: J
authors.initials: J
authors.lastname: Boyer
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012074:Remission Induction
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Facteurs prédictifs de réponse à la chimiothérapie du cancer épidermoïde de l'oesophage. Etude à propos de 60 patients et élaboration d'un score de réponse.