title: Maternal immunization with gametocyte antigens as a means of providing protective immunity against Eimeria maxima in chickens.
abstract: In the present study, we wished to demonstrate the ability of surface gametocyte antigens to induce protective immunity against Eimeria maxima infections in chickens. In order to accomplish this goal, we employed maternal immunization as a means of providing large amounts of specific antibodies to offspring chicks. Upon challenge with sporulated E. maxima oocysts, chicks from hens immunized with affinity-purified gametocyte antigens showed greatly reduced oocyst production compared with chicks from sham-immunized hens. These results suggest that maternal immunization with gametocyte antigens can be used as a means to provide transmission-blocking immunity against E. maxima infections.
authors.affiliation: Kuvin Centre for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Wallach
authors.forename: A
authors.initials: A
authors.lastname: Halabi
authors.forename: G
authors.initials: G
authors.lastname: Pillemer
authors.forename: O
authors.initials: O
authors.lastname: Sar-Shalom
authors.forename: D
authors.initials: D
authors.lastname: Mencher
authors.forename: M
authors.initials: M
authors.lastname: Gilad
authors.forename: U
authors.initials: U
authors.lastname: Bendheim
authors.forename: H D
authors.initials: HD
authors.lastname: Danforth
authors.forename: P C
authors.initials: PC
authors.lastname: Augustine
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D000953:Antigens, Protozoan / Q000276:immunology*; D002645:Chickens; D003048:Coccidiosis / Q000276:immunology; D004539:Eimeria / Q000254:growth & development; D005260:Female; D007114:Immunization; D011247:Pregnancy
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan