title: 28K antigen in the urothelium.
abstract: We have been investigating the nature of the mucosal lining of human urinary bladder. Surface material was obtained from bladders at autopsy and used for biochemical analysis. Western immunoblotting and tissue immunochemistry identified a molecule of Mr 28,000 (28K) which is present within surface cells of the urothelium (umbrella cells). Antiserum to 28K stained sections of the bladder of two patients with squamous cell carcinoma of the bladder and other patients with squamous metaplasia. We consider 28K to be a component of the normal human bladder surface that is increased in patients with squamous metaplasia and may also be present in squamous cell carcinoma of the bladder.
authors.affiliation: Department of Medicine, University of Southern California School of Medicine, Los Angeles.
authors.forename: J Z
authors.initials: JZ
authors.lastname: Montgomerie
authors.forename: A J
authors.initials: AJ
authors.lastname: Keyser
authors.forename: H J
authors.initials: HJ
authors.lastname: Holshuh
authors.forename: D G
authors.initials: DG
authors.lastname: Schick
mesh_terms: D000941:Antigens / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry*; D004848:Epithelium / Q000737:chemistry; D006801:Humans; D001743:Urinary Bladder / Q000737:chemistry*; D001749:Urinary Bladder Neoplasms / Q000737:chemistry*
chemical_list: D000941:Antigens