title: Synthesis and activity of C-21 alkylamino derivatives of (9R)-erythromycylamine.
abstract: Novel analogs of (9R)-9-deoxo-9-(N,N-dimethylamino)erythromycin A bearing N-alkylamino substituents at the C-21 position were synthesized. These compounds retained antibacterial activity. The C-21, N,N-dimethylamino analog showed a modest improvement in activity against some Gram-negative bacteria.
authors.affiliation: Abbott Laboratories, Abbott Park, IL 60064.
authors.forename: P A
authors.initials: PA
authors.lastname: Lartey
authors.forename: S L
authors.initials: SL
authors.lastname: DeNinno
authors.forename: R
authors.initials: R
authors.lastname: Faghih
authors.forename: D J
authors.initials: DJ
authors.lastname: Hardy
authors.forename: J J
authors.initials: JJ
authors.lastname: Clement
authors.forename: J J
authors.initials: JJ
authors.lastname: Plattner
mesh_terms: D001419:Bacteria / Q000187:drug effects; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C007626:erythromyclamine; D004917:Erythromycin