title: A new tetracycline antibiotic with antitumor activity. II. The structural elucidation of SF2575.
abstract: The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicyclic acid and angelic acid moieties.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hatsu
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Gomi
authors.forename: Y
authors.initials: Y
authors.lastname: Kodama
authors.forename: M
authors.initials: M
authors.lastname: Sezaki
authors.forename: S
authors.initials: S
authors.lastname: Inouye
authors.forename: S
authors.initials: S
authors.lastname: Kondo
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D008968:Molecular Conformation; D013754:Tetracyclines / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D013754:Tetracyclines; C074360:SF 2575