title: Structural relationships of actin-binding proteins.
abstract: The sequences of a large number of actin-binding proteins have been compared. These findings, together with the results of protein-chemical analysis, peptide synthesis and site-directed and deletion mutagenesis, have led to the assignment of actin-binding sites. Within these segments, small actin-binding motifs have been delineated. Most actin-binding proteins interact with actin subdomain-1 but our analyses reveal neither primary nor secondary structure homology among these proteins, suggesting that actin binding does not follow simple structural principles.
authors.affiliation: Laboratory of Physiological Chemistry, University of Ghent, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Vandekerckhove
authors.forename: K
authors.initials: K
authors.lastname: Vancompernolle
mesh_terms: D000199:Actins / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D008840:Microfilament Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D013329:Structure-Activity Relationship
chemical_list: D000199:Actins; D008840:Microfilament Proteins