title: [The immunochemical mechanisms of body adaptation to a chemical environment].
abstract: For the first time the dynamics of metabolic and immune responses to xenobiotics were analyzed in their long-term effect on the organism. It was shown that the organism gradually lost the capacity to respond to xenobiotics with the induction of hepatic cytochrome P450 and immune response. Possible mechanisms of this phenomenon are under consideration.
authors.forename: I E
authors.initials: IE
authors.lastname: Kovalev
authors.forename: N V
authors.initials: NV
authors.lastname: Shipulina
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects / Q000276:immunology*; D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000276:immunology; D004782:Environmental Health; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects / Q000276:immunology; D007120:Immunochemistry; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000276:immunology; D015262:Xenobiotics / Q000009:adverse effects* / Q000493:pharmacokinetics
chemical_list: D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System
vernacular_title: Immunokhimicheskie mekhanizmy adaptatsii organizma k okruzhaiushcheĭ khimicheskoĭ srede.