Feeding in infancy: short- and long-term effects on cardiovascular function.
Cardiovascular responses of adult organisms to feeding are well characterized and, in general, are understood as acute adaptations required for processing and distributing nutrients. Research over the past several years has shown that infants also have important cardiovascular responses to nutrient intake and that these are regulated by changes in autonomic activity to the heart and vasculature. Recent studies have provided results that suggest these responses in infancy may make an important contribution to the long-term development of cardiovascular function, in particular, adult blood pressure (BP). The purpose of this presentation will be to review the evidence that has led to this conclusion, offer ideas about how this potential early-life shaping of subsequent cardiovascular function may come about, and suggest further studies that will be required in order to characterize the mechanisms responsible for these effects.
Myers
M M
MM
Department of Psychiatry, Columbia College of Physicians and Surgeons, Columbia University, New York, NY.
Shair
H N
HN
Hofer
M A
MA
D000375:Aging; D000818:Animals; D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000254:growth & development; D006339:Heart Rate; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008425:Maternal Behavior; D009034:Mother-Child Relations; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY