Acetaldehyde, ethanol and acetone concentrations in blood of alcohol-treated mice receiving aldehyde dehydrogenase-loaded erythrocytes.
Blood levels of acetaldehyde (ACh), ethanol and acetone were investigated in mice treated with ethanol for 6 months and receiving compatible erythrocytes (RBCs) overloaded with aldehyde dehydrogenase (AlDH). Following an acute dose of ethanol, ACh levels were significantly lower in these animals than in alcohol-treated mice receiving AlDH-unloaded RBCs, and were similar to the ACh levels of normal mice. The peak ethanol concentration was higher in normal mice than in both groups of alcohol-treated animals, while acetone concentrations were not significantly different in the three groups of animals.
Ninfali
P
P
Istituto di Chimica Biologica, Università degli Studi, Urbino, Italy.
Rossi
L
L
Baronciani
L
L
Tirillini
B
B
Ropars
C
C
Magnani
M
M
D000079:Acetaldehyde / Q000097:blood*; D000096:Acetone / Q000097:blood*; D000437:Alcoholism / Q000201:enzymology*; D000444:Aldehyde Dehydrogenase / Q000097:blood*; D000818:Animals; D016913:Blood Component Transfusion; D004912:Erythrocytes / Q000201:enzymology*; D000431:Ethanol / Q000493:pharmacokinetics*; D008099:Liver / Q000201:enzymology; D008111:Liver Function Tests; D008657:Metabolic Clearance Rate / Q000502:physiology; D051379:Mice
D000096:Acetone; D000431:Ethanol; D000444:Aldehyde Dehydrogenase; D000079:Acetaldehyde