title: Carcinoma in situ, gonadoblastoma, and early invasive neoplasia in a nine-year-old girl with 46,XY gonadal dysgenesis.
abstract: Carcinoma in situ (CIS), gonadoblastoma, and early invasive neoplasia were detected in the dysgenetic gonad of a nine-year-old girl with 46,XY gonadal dysgenesis. A close relationship between the three neoplastic components was supported by morphological and immunohistochemical studies. Our findings support the hypothesis that all germ cell tumours, including gonadoblastomas, originate from CIS germ cells formed during early embryonic life.
authors.affiliation: University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: J
authors.initials: J
authors.lastname: Visfeldt
authors.forename: J
authors.initials: J
authors.lastname: Philip
authors.forename: N E
authors.initials: NE
authors.lastname: Skakkebaek
mesh_terms: D002278:Carcinoma in Situ / Q000235:genetics / Q000473:pathology*; D002648:Child; D004407:Dysgerminoma / Q000235:genetics / Q000473:pathology*; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications*; D006801:Humans; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology*