Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
We found deletions of both alleles of the retinoblastoma gene (Rb) and the candidate Wilms' tumor gene (WT33) in a surgically resected human insulinoma by blot hybridization. Rearrangement of Krev-1, a transformation suppressor gene, was also detected in this case. The clinical and histological findings suggested that this tumor would be a benign insulinoma. The result suggests that the inactivation of multiple tumor suppressor genes could be involved even in the development of benign human tumors.
Iwamura
Y
Y
Department of Microbiology, University of Tsukuba.
Futagawa
T
T
Kaneko
M
M
Nakagawa
K
K
Kawai
K
K
Yamashita
K
K
Nakamura
T
T
Hayashi
H
H
D000368:Aged; D002872:Chromosome Deletion; D005260:Female; D015321:Gene Rearrangement; D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor; D016162:Genes, Wilms Tumor; D006801:Humans; D007340:Insulinoma / Q000235:genetics*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics*