Simultaneous occurrence of t(14;18) and t(8;22) common acute lymphoblastic leukemia.
A young male patient progressed rapidly from localized abdominal lymph node enlargement to overt acute lymphoblastic leukemia. Despite aggressive treatment, he died of progressive CNS leukemia 5 months after initial presentation. At diagnosis, karyotypic analysis of an abdominal lymph node revealed the coexistence of t(14;18) (q32;q21), specific for follicular lymphoma, and t(8;22) (q24;q11), a variant Burkitt translocation. Such cases might be considered as a model for a general mechanism of tumor progression with cascade-like involvement of oncogenes.
Marosi
C
C
First Department of Medicine, University of Vienna, Austria.
Bettelheim
P
P
Chott
A
A
Köller
U
U
Kreiner
G
G
Steger
G
G
Jäger
U
U
Pirc-Danoewinata
H
H
Lechner
K
K
D000328:Adult; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D014178:Translocation, Genetic