[Efficacy of preoperative adjuvant chemotherapy using adriamycin targeting the regional lymph nodes for gastric cancer--lymph node-targeting delivery of adriamycin in rabbits].
Chemotherapy targeting the regional lymph nodes for gastric cancer may be more effective preoperatively than postoperatively since anticancer drugs can be transported to the regional lymph nodes via the lymphatic flow through the stomach. Distribution of Adriamycin (ADR) among the various organs was assessed following its intravenous injection in rabbits. The delivery index of the drug to each organ was assessed by the ratio of the area under the concentration-time curve (AUC) of each organ to the AUC of the regional lymph nodes following the intravenous administration. The delivery index was 0.14 for the stomach, 0.11 for the heart, 0.53 for bone marrow, 0.74 for the spleen, and 0.14 for the liver. These data suggest that preoperative adjuvant chemotherapy by intravenous administration of ADR may be effective in targeting ADR at the regional lymph nodes. Tissue ADR concentrations in the regional lymph nodes were assessed following gastric submucosal administration of ADR in rabbits. The targeting index for the regional lymph nodes was 8.20, measured by the ratio of AUC following a gastric submucosal injection to AUC after the intravenous injection of ADR. This suggests that it may be possible to selectively target chemotherapy to regional lymph nodes by employing a gastric submucosal administration of ADR.
Akamo
Y
Y
First Dept. of Surgery, School of Medicine, Nagoya City University, Japan.
Mizuno
I
I
Ichino
T
T
Yamamoto
T
T
Yasui
T
T
Itabashi
Y
Y
Saito
T
T
Kurahashi
S
S
Tanimoto
N
N
Shinagawa
N
N
D000818:Animals; D017024:Chemotherapy, Adjuvant; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D005753:Gastric Mucosa / Q000378:metabolism; D008198:Lymph Nodes / Q000378:metabolism*; D011300:Preoperative Care; D011817:Rabbits; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D004317:Doxorubicin