title: Evolution of osteocalcin, alkaline phosphatase and parathyroid hormone after parathyroidectomy in patients receiving chronic maintenance hemodialysis.
abstract: Parathyroid hormone (PTH), osteocalcin and alkaline phosphatase (AP) were investigated before and after parathyroidectomy in 12 patients receiving hemodialysis. Early post-parathyroidectomy, PTH decreased (p less than 0.001), AP increased (p less than 0.05), but osteocalcin remained unchanged. At 3 months, osteocalcin and AP declined. A negative correlation was observed between aluminum staining and post-parathyroidectomy osteocalcin. In conclusion, early post-parathyroidectomy, osteocalcin and AP reflect persistent osteoblastic activity, which declined after 3 months. In patients receiving hemodialysis both variables may represent different aspects of osteoblastic activity and osteocalcin allows mixed uremic osteodystrophy after parathyroidectomy.
authors.affiliation: Department of Rheumatology, Saint Pierre Hospital, Free University of Brussels, Belgium.
authors.forename: A M
authors.initials: AM
authors.lastname: Peretz
authors.forename: M M
authors.initials: MM
authors.lastname: Dhaene
authors.forename: A
authors.initials: A
authors.lastname: Drowart
authors.forename: P
authors.initials: P
authors.lastname: Kinnaert
authors.forename: F M
authors.initials: FM
authors.lastname: Vertongen
authors.forename: P P
authors.initials: PP
authors.lastname: Bourdoux
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood*; D016105:Parathyroidectomy; D011184:Postoperative Period; D011446:Prospective Studies; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D010281:Parathyroid Hormone; D015675:Osteocalcin; D000469:Alkaline Phosphatase