[The calcium and phosphorus content of the bone tissue in ovariectomized rats with a fracture of the tibia: the effect of vitamin K and vitamin D metabolites].
Calcium and phosphorus content in the bone tissue of ovariectomized rats with a shinbone fracture has been estimated. It was found out that unlike pseudo-operated animals whose fracture was accompanied by a decrease of calcium and phosphorus content and density in the right proximal epiphysis of the femur, in case of ovariectomized rats those parameters increased. Under those conditions a decrease in the epiphysis density and calcium and phosphorus content both in the shinbone and in the femur of the left extremity was similar both in pseudo-operated and ovariectomized rats. Administration of 1 alpha (OH)D3, 24R, 25(OH)2D3 and vitamin K to ovariectomized animals with a shinbone fracture produced no positive effect on the bone tissue, which anyhow, did not exclude a possibility of a positive effect in other doses and for a longer period of time.
Sokol'nikov
A A
AA
Kodentsova
V M
VM
Spirichev
V B
VB
D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy / Q000378:metabolism; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013978:Tibial Fractures / Q000188:drug therapy / Q000378:metabolism*; D014807:Vitamin D / Q000627:therapeutic use*; D014812:Vitamin K / Q000627:therapeutic use*
D014812:Vitamin K; D014807:Vitamin D; D010758:Phosphorus; D002118:Calcium
Soderzhanie kal'tsiia i fosfora v kostnoĭ tkani u ovariéktomirovannykh krys s perelomom bol'shoĭ bertsovoĭ kosti: vliianie vitamina K i metabolitov vitamina D.