Direct effect of thyroid hormone on left ventricular myocardial relaxation.
The left ventricular diastolic indices of the hyperthyroid (HTH) patients without cardiac disease (n = 31) were compared with those of the normal controls (NC) (n = 49) using echocardiography. The HTH group had a significantly shorter IIa-mitral valve opening time (IIa-MVO), and a significantly larger maximum descending rate of the left ventricular posterior wall (maxPWDR), peak E and peak A than the NC group. IIa-MVO, maxPWDR, peak E and E/A showed significant simple correlation with T3 in the HTH group. To elucidate spurious correlation among these indices and T3, partial correlation analysis among these indices and its influencing factors were calculated. IIa-MVO, maxPWDR and peak E showed significant partial correlation coefficients with T3, but peak E had a lesser partial correlation with T3 than with age and left ventricular end-diastolic volume. Fourteen of the hyperthyroid patients were reexamined after antithyroid treatment. Their diastolic indices were found to be normalized compared with pre-treatment values and showed no significant difference with those of NC group. Augmented myocardial relaxation in patients with hyperthyroidism correlated with the thyroid hormone level, and IIa-MVO and maxPWDR were more effective indices of left ventricular myocardial relaxation than peak E and E/A in hyperthyroidism.
Dazai
Y
Y
Department of Internal Medicine, Yawatahama City General Hospital, Ehime, Japan.
Katoh
I
I
Yoshida
R
R
D000328:Adult; D000368:Aged; D003971:Diastole; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013961:Thyroid Gland / Q000503:physiopathology; D013963:Thyroid Hormones / Q000502:physiology*; D014284:Triiodothyronine / Q000097:blood; D016277:Ventricular Function, Left
D013963:Thyroid Hormones; D014284:Triiodothyronine