title: Occurrence of antinuclear antibodies in an unselected pregnancy population.
abstract: The occurrence of antinuclear antibodies (ANA) in an unselected population of pregnant women was studied by an indirect immunofluorescence method. Six women out of 116 were ANA-positive (5.2%), 2 of them having a moderately high titre (1:160 and 1:320) and 1 complement-fixing ANA. The antigenic specificity of ANA was anti-single-stranded DNA in 2 cases and RNAase-sensitive anti-extractable nuclear antigen in 1 case. Two of the ANA-positive women had pre-eclampsia laevis and 1 had a premature delivery. None of the infants of the ANA-positive women had symptoms of connective tissue disease. The occurrence of ANA among pregnant women was not significantly higher than among 70 non-pregnant female control subjects (7.1%).
authors.affiliation: Department of Medical Microbiology, University of Oulu, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Kiuttu
authors.forename: A L
authors.initials: AL
authors.lastname: Hartikainen-Sorri
authors.forename: R
authors.initials: R
authors.lastname: Mäkitalo
mesh_terms: D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D003168:Complement Fixation Tests; D004247:DNA / Q000276:immunology*; D004277:DNA, Single-Stranded / Q000276:immunology*; D005260:Female; D005387:Finland; D005455:Fluorescent Antibody Technique; D006386:Hemagglutination Tests; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000235:genetics / Q000276:immunology; D007075:Immunoglobulin M / Q000032:analysis / Q000235:genetics / Q000276:immunology; D007752:Obstetric Labor, Premature / Q000235:genetics / Q000276:immunology*; D010298:Parity; D011225:Pre-Eclampsia / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy / Q000235:genetics / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D004247:DNA