Duplication mitosis in carcinoma.
As proposed in 'Duplication mitosis in epithelio-glandular tissue' (1), histological continuity is dependent on duplication mitosis. Organoid continuity of carcinomas is also likely to be dependent on duplication mitosis. Cancerous duplication may be due to deterioration of the maturation capacity of carcinoma cells and caused by a cellular abnormality that rejects the effect of the maturation factor. The fundamental therapeutic approach to carcinoma should be altered from one of cell destruction to one of inducing cell-phase maturation.
Hirata
Y
Y
Hirata Hospital, Kochi City, Japan.
D002454:Cell Differentiation; D006801:Humans; D008938:Mitosis; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D014411:Neoplastic Stem Cells / Q000473:pathology