title: Common variable immunodeficiency in a family.
abstract: Common variable immunodeficiency (CVID) is mainly characterised by hypo- or agammaglobulinaemia of late onset, usually discovered in the second decade of life. In individuals CVID is associated with a variable impairment of cellular immunity and the susceptibility to microbial infection may vary as well. CVID is described in a mother and a son who suffered from serious bacterial infections. In addition, minor immunological test abnormalities of apparently healthy first degree relatives are described.
authors.affiliation: Department of Internal Medicine, Oncology/AIDS division, Medisch Spectrum Twente/Ziekenhuis Enschede, Netherlands.
authors.forename: D J
authors.initials: DJ
authors.lastname: Van Spronsen
authors.forename: M
authors.initials: M
authors.lastname: Kerbert-Dreteler
authors.forename: G
authors.initials: G
authors.lastname: van der Sluijs Veer
authors.forename: C H
authors.initials: CH
authors.lastname: ten Napel
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000235:genetics* / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010375:Pedigree
chemical_list: D007136:Immunoglobulins