P300 as indicator of effects of prophylactic cranial radiation.
In order to assess the late adverse effects of cranial radiation on the central nervous system, 33 children with acute lymphocytic leukemia were examined through event-related potential P300, brain response analysis. P300 latency was significantly prolonged in children who received both prophylactic cranial radiation and intrathecal methotrexate. Although a longitudinal study is necessary, we believe that P300 is useful in the assessment of the adverse effects of cranial radiation in children with acute lymphocytic leukemia.
Sato
T
T
Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
Miyao
M
M
Muchi
H
H
Gunji
Y
Y
Iizuka
A
A
Yanagisawa
M
M
D000161:Acoustic Stimulation; D001143:Arousal / Q000187:drug effects / Q000528:radiation effects*; D001921:Brain / Q000528:radiation effects*; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000175:diagnosis*; D002540:Cerebral Cortex / Q000187:drug effects / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004569:Electroencephalography / Q000187:drug effects / Q000528:radiation effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000139:chemically induced / Q000175:diagnosis*; D011879:Radiotherapy Dosage; D011930:Reaction Time / Q000187:drug effects / Q000528:radiation effects; D012307:Risk Factors
D008727:Methotrexate