title: Mania associated with fluoxetine treatment in adolescents.
abstract: Fluoxetine, a selective serotonin reuptake inhibitor, is gaining increased acceptance in the treatment of adolescent depression. Generally safe and well tolerated by adults, fluoxetine has been reported to induce mania. The cases of five depressed adolescents, 14-16 years of age, who developed mania during pharmacotherapy with fluoxetine, are reported here. Apparent risk factors for the development of mania or hypomania during fluoxetine pharmacotherapy in this population were the combination of attention-deficit hyperactivity disorder and affective instability; major depression with psychotic features; a family history of affective disorder, especially bipolar disorder; and a diagnosis of bipolar disorder. Further study is needed to determine the optimal dosage and to identify risk factors that increase individual vulnerability to fluoxetine induced mania in adolescents.
authors.affiliation: University of Michigan Department of Psychiatry, Ann Arbor 48109-0290.
authors.forename: S
authors.initials: S
authors.lastname: Venkataraman
authors.forename: M W
authors.initials: MW
authors.lastname: Naylor
authors.forename: C A
authors.initials: CA
authors.lastname: King
mesh_terms: D000293:Adolescent; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects*; D006760:Hospitalization; D006801:Humans
chemical_list: D005473:Fluoxetine