Bacterial vaginosis: treatment with clindamycin cream versus oral metronidazole.
In a randomized, double-blind study, 48 women with symptomatic bacterial vaginosis were assigned to receive either 5 g of 2% clindamycin vaginal cream daily or 500 mg metronidazole oral tablets twice a day for 7 days. After completion of therapy, there was no significant difference in cure rates (clindamycin 72% versus metronidazole 87%). One month later, 61% of the patients in each group were still cured. Adverse reactions were mild in both groups. We conclude that clindamycin cream is a safe, well tolerated, and effective alternative to oral metronidazole for treatment of bacterial vaginosis.
Schmitt
C
C
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan.
Sobel
J D
JD
Meriwether
C
C
D000284:Administration, Oral; D000328:Adult; D002981:Clindamycin / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011446:Prospective Studies; D014622:Vaginal Creams, Foams, and Jellies; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
D014622:Vaginal Creams, Foams, and Jellies; D008795:Metronidazole; D002981:Clindamycin