title: Serum levels of immunoreactive thymosin alpha 1 and thymosin beta 4 in large cohorts of healthy adults.
abstract: Enzyme linked immunosorbent assays were used to measure serum levels of immunoreactive thymosin alpha 1 and thymosin beta 4 in 681 healthy adults (range 18 yr-101 yr). Immunoreactive thymosin alpha 1 was found to occur at a geometric mean of 540 pg/ml with a range from 252 to 1158 pg/ml. There were no differences in the levels when analyzed according to race, sex or age. Immunoreactive thymosin beta 4 was measured at a geometric mean of 12.6 ng/ml with a range from 6.9 to 23.0 ng/ml. There were no differences in the levels when analyzed according to race or sex, however, there was a slight upward trend with increasing age. This data may be useful as a reference when monitoring clinical studies, determining the kinetics of drug metabolism and distinguishing patient groups with elevated levels of either of these peptides.
authors.affiliation: Department of Medicine, Wayne State University School of Medicine, Detroit, MI 48201.
authors.forename: F E
authors.initials: FE
authors.lastname: Weller
authors.forename: U
authors.initials: U
authors.lastname: Shah
authors.forename: G D
authors.initials: GD
authors.lastname: Cummings
authors.forename: P B
authors.initials: PB
authors.lastname: Chretien
authors.forename: M G
authors.initials: MG
authors.lastname: Mutchnick
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077596:Thymalfasin; D013947:Thymosin / Q000031:analogs & derivatives* / Q000097:blood; D000099201:Thymosin beta(4)
chemical_list: D000077596:Thymalfasin; D013947:Thymosin; D000099201:Thymosin beta(4)