GM-CSF therapy for drug-induced agranulocytosis.
Five patients with drug-induced agranulocytosis were treated with recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF)). With the exception of one patient who experienced a very short period of neutropenia, GM-CSF did not appear to alter the natural course of the disease. From our experience and from a critical review of the literature we conclude that the efficacy of GM-CSF in agranulocytosis is far from certain, and that the use of growth factors in this condition remains investigational.
Delannoy
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Department of Hematology, Hôpital de Jolimont, La Louvière, Belgium.
D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor