Bone marrow granulomas in acute myeloid leukaemia following interleukin 2 and lymphokine-activated killer cells.
Granulomas are thought to represent an immune reaction to antigenic stimulation. Bone marrow granulomas are uncommon, but in the following case report we show their transient appearance after interleukin 2 (IL-2) and autologous lymphokine-activated killer cell therapy. This is a previously unreported association, and may implicate IL-2 in the pathogenesis of granulomas.
O'Brien
D V
DV
Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
Boon
A P
AP
Boughton
B J
BJ
D000328:Adult; D001855:Bone Marrow Diseases / Q000209:etiology*; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D015979:Killer Cells, Lymphokine-Activated; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy*; D008297:Male
D007376:Interleukin-2