Autoantibodies to the chromosomal protein HMG-17 in juvenile rheumatoid arthritis.
OBJECTIVE
To determine the antibody profiles in sera from patients with juvenile rheumatoid arthritis (JRA).


METHODS
Immunoblotting using nuclear extracts and recombinant high-mobility group (HMG) nonhistone chromosomal proteins.


RESULTS
Antibodies directed against HMG-17 were found in 47% of antinuclear antibody (ANA)-positive patients with pauciarticular-onset JRA and in 16% of ANA-positive patients with polyarticular-onset JRA. HMG-17 values of 6% and 8%, respectively, were detected in ANA-negative patients with JRA and in those with nonrheumatic diseases.


CONCLUSIONS
There is evidence for a high prevalence of anti-HMG-17 antibodies in sera of patients with pauciarticular-onset JRA.
Neuer
G
G
Institute of Molecular Genetics, University of Heidelberg, Federal Republic of Germany.
Bustin
M
M
Michels
H
H
Truckenbrodt
H
H
Bautz
F A
FA
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001171:Arthritis, Juvenile / Q000276:immunology* / Q000503:physiopathology; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006609:High Mobility Group Proteins / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D008297:Male
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006609:High Mobility Group Proteins