title: Sertoli-Leydig cell tumor of the ovary: a rare cause of amenorrhea.
abstract: A 15-year-old girl presented to a primary care clinic with secondary amenorrhea, masculinization, and rapidly increasing abdominal girth. Evaluation revealed a large pelvic mass, which was found at laparotomy to be a bilateral Sertoli-Leydig cell tumor producing androgens and high levels of alpha-fetoprotein (AFP). The patient underwent bilateral salpingo-oophorectomy. Other pelvic structures were uninvolved. The postoperative course was unremarkable, with testosterone and AFP levels in the normal range. A thorough literature search revealed no cases in which bilateral Sertoli-Leydig cell tumors were associated with high AFP levels. This case was unusual in its pathology, dramatic in its presentation, and valuable in its implications regarding the work-up of amenorrhea in young women.
authors.affiliation: Family Practice Residency Program, Santa Monica Hospital Medical Center, California.
authors.forename: W G
authors.initials: WG
authors.lastname: Larsen
authors.forename: E A
authors.initials: EA
authors.lastname: Felmar
authors.forename: M E
authors.initials: ME
authors.lastname: Wallace
authors.forename: R
authors.initials: R
authors.lastname: Frieder
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D007984:Leydig Cell Tumor / Q000150:complications* / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D012707:Sertoli Cell Tumor / Q000150:complications* / Q000473:pathology