title: [Intraperitoneal chemotherapy for ovarian adenocarcinoma: pharmacokinetics of cisplatin].
abstract: Chemotherapy using cis dichlorodiamine platinum (CDDP) in doses of 30 and 60 mg/m2 was carried out in 6 patients who had adenocarcinoma of the ovary, that had not been treated before, 15 to 120 minutes before surgery was carried out. The results of doses of platin given on the blood levels are demonstrated. A slight and progressive increase in the plasma levels of CDDP with peaks between 0.6 and 1.95 of total platinum and 0.22 mcg/ml of free platin were found. The tissue levels in the region of the ovaries were found to be between 0.16 and 0.94 mcg/mg. There was a stepwise increase in the levels found in the pathological peritoneal cover of between 0.42 and 31.2 mcg/mg. This dropped as time went by; and then led to change in accordance with the intra-peritoneal concentrations. This study shows that it is possible when giving drugs intraperitoneally to avoid high plasma peaks and to obtain good levels of concentration of cisplatin in the peritoneum.
authors.affiliation: Service de Gynécologie-Obstétrique, Hôpital Lariboisière, Paris.
authors.forename: J H
authors.initials: JH
authors.lastname: Ravina
authors.forename: A
authors.initials: A
authors.lastname: Szyller
authors.forename: P
authors.initials: P
authors.lastname: Mintz
authors.forename: S
authors.initials: S
authors.lastname: Ferrand
authors.forename: N
authors.initials: N
authors.lastname: Ciraru-Vigneron
authors.forename: B
authors.initials: B
authors.lastname: Zylberberg
authors.forename: R
authors.initials: R
authors.lastname: Bourdon
authors.forename: M
authors.initials: M
authors.lastname: Galliot
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D001706:Biopsy; D002945:Cisplatin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
chemical_list: D002945:Cisplatin
vernacular_title: Chimiothérapie intrapéritonéale pour adénocarcinome ovarien: pharmacocinétique du cisplatine.