Effects of ketanserin on blood pressure and heart rate in sinoaortic denervated rats.
The effects of ketanserin on blood pressure and heart rate were studied in sinoaortic denervated (SAD) rats. It was found that the dose-effect curves for blood pressure and heart rate were the same in anesthetized SAD and sham-operated rats. However, SAD sharpened the dose-effect curves in conscious freely moving rats. It is concluded that the lack of hypotensive effect of ketanserin in conscious normotensive animals is due in large part to the integrity of the arterial baroreflex.
Su
D F
DF
Department of Pharmacology, Second Military Medical University, Shanghai, China.
Yang
Y C
YC
Xie
J E
JE
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003714:Denervation; D006339:Heart Rate / Q000187:drug effects*; D007650:Ketanserin / Q000494:pharmacology*; D008297:Male; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000502:physiology
D007650:Ketanserin