title: Evolution of influenza A(H1N1) viruses during a period of low antigenic drift in 1986-91: sequence of the HA1 domain of influenza A/Finland/158/91.
abstract: This study used the nucleotide sequence coding for the HA1 domain of virus haemagglutinin to show that influenza A/Finland/158/91, which represents the H1N1 subtype viruses prevalent in Finland in 1990/91, was a direct descendant of a virus (A/NN/1605/88) isolated during the 1988/89 epidemic season in Japan. The elevated rate of 7.4 x 10(-3) nucleotide substitutions per site per year is discussed. The new branch of H1N1 subtype viruses is characterized by loss of a glycosylation site, which may affect subsequent antigenic drift.
authors.affiliation: National Public Health Institute (NPHI), Helsinki.
authors.forename: L
authors.initials: L
authors.lastname: Kinnunen
authors.forename: N
authors.initials: N
authors.lastname: Ikonen
authors.forename: T
authors.initials: T
authors.lastname: Pöyry
authors.forename: R
authors.initials: R
authors.lastname: Pyhälä
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D005387:Finland; D006389:Hemagglutinins, Viral / Q000235:genetics*; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*
chemical_list: D006389:Hemagglutinins, Viral