Fast-computed tomography evaluation of age-related changes in upper airway structure and function in normal men.
The reasons for the increase prevalence of snoring and sleep-disordered breathing in elderly adults are not clear. We hypothesized that age-related reductions in upper airway (UA) size, increased UA collapsibility, and/or inadequate compensatory action of the UA dilator muscles were contributory factors. Fast-computed tomography (CT) was used to examine UA size at FRC and atmospheric pressure, as well as its collapsibility and distensibility in response to negative and positive UA pressures actively generated by the subjects at FRC. The electromyographic activity of the genlogiossal muscle group (EMGgg) was recorded to assess UA dilator muscle response. Thirty adult men with normal overnight polysomnography (mean AHI = 4 +/- 1/h) were studied, and three subgroups of 10 subjects each, young (20-39), middle-age (40-59), and old (60-79), were compared. Unexpectedly, minimal UA cross-sectional area (Amin) at FRC and atmospheric pressure was larger in the old group than in the young group (73 +/- 9 versus 49 +/- 7 mm2, p = 0.04). In response to negative UA pressures of -10 and -50 cm H2O, there were no significant age group differences in Amin, indicating that no age-related increase in UA collapsibility was present. Although no significant difference in tonic EMGgg activity at FRC and atmospheric pressure was detected between groups, the old group demonstrated greater EMGgg activity than did the younger age groups in response to negative UA pressure loading (p less than 0.05). This finding indicated increased compensatory UA dilator muscle activity in response to negative pressures in the older subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Burger
C D
CD
Sleep Disorder Center, Mayo Clinic, Rochester, MN 55905.
Stanson
A W
AW
Sheedy
P F
PF
Daniels
B K
BK
Shepard
J W
JW
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D004576:Electromyography; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D012132:Respiratory Muscles / Q000502:physiology*; D012143:Respiratory Physiological Phenomena; D012137:Respiratory System / Q000000981:diagnostic imaging*; D012890:Sleep / Q000502:physiology; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000517:prevention & control; D014057:Tomography, X-Ray Computed / Q000379:methods*