title: [Moisture retaining effect and tolerance of urea-containing Externa in neurodermatitis patients].
abstract: Urea ointments and emulsions are excellently suited for the care and supportive therapy of neurodermatitis patients. In treating children and in the case of acutely irritated skin conditions, we have arrived at a concentration of 5% urea. All other dermatological conditions can be easily and effectively treated with a 10% urea preparation. It goes without saying that galenics also play an important role. An unbalanced composition can lead to poor results. In a short-term test (180 minutes) and in a long-term test (7 days), we tested the moisture level of the corneal layer with the corneometer in a climate-controlled room. We were able to show that urea in hydrous topical agents ensures acceleration of corneal hydration and helps retain water in the corneal layer. Thus, urea preparations can also be especially recommended for use in patients with neurodermatitis.
authors.affiliation: Universitäts-Hautklinik, Halle.
authors.forename: K M
authors.initials: KM
authors.lastname: Taube
mesh_terms: D003876:Dermatitis, Atopic / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D009824:Ointments; D013546:Sweating / Q000187:drug effects*; D014508:Urea / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014870:Water Loss, Insensible / Q000187:drug effects*
chemical_list: D009824:Ointments; D014508:Urea
vernacular_title: Feuchthalteeffekt und Verträglichkeit von harnstoffhaltigen Externa bei Neurodermitikern.