Adrenal contribution to the induction of sexual behavior in the female musk shrew.
Sexually experienced female musk shrews (Suncus murinus) lack an ovarian, vaginal, and behavioral estrous cycle. Females, once induced by their initial contact with a male, are able to display copulatory behavior whenever a male is present (Rissman, Silveira, and Bronson, 1988). Based on plasma levels of steroids, and on hormone replacement studies conducted after ovariectomy (OVX), we have shown that testosterone (T) plays an essential role in the regulation of female sexual behavior (Rissman and Crews, 1988; Rissman, Clendenon, and Krohmer, 1990a; Rissman, 1991). To date we have only examined the potential contribution of adrenal steroids to female sexual behavior in a preliminary manner. After adrenalectomy, gonadally intact females display significantly lower levels of sexual behavior than controls (Rissman and Bronson, 1987). The following experiments were conducted to examine the role the adrenal steroids (in contrast to the medullary hormones) play in the induction of female sexual behavior in the musk shrew. In the first experiment gonadally intact females were treated with dexamethasone (DEX) to reduce the secretion of adrenal steroids. Significantly fewer females receiving DEX demonstrated sexual behavior as compared with controls. In the second study, OVX females received T-filled Silastic implants. When DEX was administered to OVX + T females at a dose that dropped circulating T levels to those found in ovary and adrenal intact females, no effect on sexual behavior was noted. The data show that the adrenals are a behaviorally important source of T and contribute toward the hormonal control of sexual behavior in these female mammals.
Fortman
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NSF Center for Biological Timing, Department of Biology, University of Virginia, Charlottesville 22901.
Dellovade
T L
TL
Rissman
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EF
D000311:Adrenal Glands / Q000502:physiology*; D000374:Aggression / Q000502:physiology; D000728:Androgens / Q000502:physiology; D000818:Animals; D003307:Copulation / Q000502:physiology; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000502:physiology*; D012741:Sexual Maturation / Q000502:physiology*; D012788:Shrews / Q000502:physiology*; D013739:Testosterone / Q000502:physiology
D000728:Androgens; D012739:Gonadal Steroid Hormones; D013739:Testosterone