[HTLV-I retroviral variant in Zaire in patient with chronic neuromyelopathy. Nucleotidic sequence of the envelope gene].
The oncoretrovirus HTLV-I is the etiological agent of adult T cell leukemia (ATL) and tropical spastic paraparesis/HLTV-I associated myelopathy (TSP/HAM). In contrast to the human lentiretroviruses, HIV-I and HIV-2, the causative agents of AIDS, HTLV-I is genetically very stable. We report here the molecular characterization of the envelope gene of an HTLV-I variant present in a TSP/HAM patient from Zaïre, raising the question of its relevance to disease or the ethnic and/or geographical origin of the patient.
Gessain
A
A
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institute of Health, Bethesda.
Boeri
E
E
Kazadi
K
K
Garin
B
B
Salaün
J J
JJ
Gallo
R
R
de Thé
G
G
Franchini
G
G
D001483:Base Sequence; D002908:Chronic Disease; D015023:Democratic Republic of the Congo; D015752:Genes, env / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000382:microbiology*
Variant retroviral HTLV-I au Zaïre chez un patient ayant une neuromyélopathie chronique. Séquence nucléotidique du gène d'enveloppe.