Acute pancreatitis associated with ketoprofen.
An 80-year-old man had acute pancreatitis during the fourth week of antibiotic therapy for enterococcal endocarditis and 12 days after initiation of ketoprofen therapy for osteoarthritis of the hip. Pancreatitis resolved after discontinuance of ketoprofen therapy and while continuing antibiotic therapy for endocarditis. Common causes of pancreatitis were excluded by laboratory testing. Ketoprofen may have been the cause of pancreatitis in this case; we have suggested two possible mechanisms related to prostaglandin inhibition.
Cobb
T K
TK
Department of Internal Medicine, Texas Tech University School of Medicine, Amarillo.
Pierce
J R
JR
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects*; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*
D007660:Ketoprofen