title: Effect of aging on metabolic zonation in rat liver: acinar distribution of GSH metabolism.
abstract: The effect of age on the glutathione antioxidant system and its acinar distribution in rat liver was studied. GSH/GSSG ratio in blood and liver was lower in old than in young rats. Hepatic glutathione peroxidase and glutathione S-transferase activities were higher in old than in young rats, whereas hepatic gamma-glutamyl transpeptidase activity was lower in old than in young rats. Glutathione reductase and glucose-6-phosphate dehydrogenase activities did not change with age in rat liver. Total glutathione levels and glutathione peroxidase activity were higher in periportal than in perivenous areas of young rats, but this heterogeneous distribution did not occur in old rats. No change with age was found in hepatic zonation of glutathione reductase and glucose-6-phosphate dehydrogenase.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universitat de Valencia, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Sastre
authors.forename: J V
authors.initials: JV
authors.lastname: Rodriguez
authors.forename: F V
authors.initials: FV
authors.lastname: Pallardó
authors.forename: E
authors.initials: E
authors.lastname: Gasco
authors.forename: M
authors.initials: M
authors.lastname: Asensi
authors.forename: J V
authors.initials: JV
authors.lastname: Ferrer
authors.forename: J
authors.initials: J
authors.lastname: Miquel
authors.forename: J
authors.initials: J
authors.lastname: Viña
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism*; D019803:Glutathione Disulfide; D008099:Liver / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D008315:Malondialdehyde; D005978:Glutathione; D019803:Glutathione Disulfide