[Complement activation by C-reactive protein in various inflammatory diseases (in vitro)].
C-reactive protein (CRP)-mediated complement activation can be tested on cryostat sections of the rat kidney by indirect immunofluorescence (C3-IFT). In contrast to a positive C3-IFT regularly obtained with sera of patients with polymyalgia rheumatica, we found unexpectedly negative C3-IFT results in 5/18 patients with seropositive rheumatoid arthritis and in 11/14 patients with bacterial endocarditis in spite of elevated CRP and normal hemolytic complement in these sera. Differential diagnostic and pathophysiological aspects of these findings are addressed.
Vaith
P
P
Abteilung für Rheumatologie und Klinische Immunologie, Universitätsklinik Freiburg.
Schlayer
M
M
Engelter
S
S
Peter
H H
HH
D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D002097:C-Reactive Protein / Q000502:physiology*; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D004697:Endocarditis, Bacterial / Q000503:physiopathology; D006801:Humans; D066298:In Vitro Techniques; D011111:Polymyalgia Rheumatica / Q000503:physiopathology*; D012217:Rheumatoid Factor / Q000032:analysis
D003176:Complement C3; D003181:Complement C4; D002097:C-Reactive Protein; D012217:Rheumatoid Factor
Komplementaktivierung durch C-reaktives Protein bei verschiedenen inflammatorischen Erkrankungen (in vitro).