title: Cervical ripening: a randomized study comparing prostaglandin E2 gel to prostaglandin E2 suppositories.
abstract: Prostaglandin (PG) E2 has proven effective in many studies as a pre-induction agent for cervical ripening. The purpose of this study was to compare the efficacy of a 5-mg dose of PGE2 prepared gel with that of a quartered PGE2 20-mg suppository. Previous studies have documented uniform distribution of PGE2 in the suppository. After 90 patients entered the study, there appeared to be an unacceptable rate of hyperstimulation following the induction dose using the suppository. The study was discontinued, and data analysis revealed a 24% hyperstimulation rate with the quartered suppository versus 0% with the gel. The successful vaginal delivery rates were equivalent, at 75% for the gel and 66% for the suppository. The 5-mg quartered suppository appeared to initiate an unacceptable amount of uterine activity, much greater than with the 5-mg gel dose.
authors.affiliation: St. Luke's Perinatal Center, St. Luke's Hospital, Kansas City, Missouri.
authors.forename: D
authors.initials: D
authors.lastname: Perryman
authors.forename: J D
authors.initials: JD
authors.lastname: Yeast
authors.forename: V
authors.initials: V
authors.lastname: Holst
mesh_terms: D000282:Administration, Intravaginal; D001034:Apgar Score; D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D015232:Dinoprostone / Q000008:administration & dosage*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005782:Gels; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D007751:Labor, Induced; D013488:Suppositories; D014590:Uterine Contraction / Q000187:drug effects
chemical_list: D005782:Gels; D013488:Suppositories; D015232:Dinoprostone