title: Incorporation of N-acyl-2-amino-2-deoxy-hexoses into glycosphingolipids of the pheochromocytoma cell line PC 12.
abstract: The synthesis of N-acyl-2-amino-2-deoxy-hexoses, their metabolism and their incorporation into glycosphingolipids of rat pheochromocytoma cell line PC 12 were investigated. The data indicate that in PC 12 cells the N-acyl-2-amino-2-deoxy-hexoses, N-propanoyl-D-glucosamine and N-butanoyl-D-glucosamine are metabolized to the corresponding phosphates, and that N-propanoyl-D-glucosamine is also metabolized to N-propanoyl neuraminic acid. Using variously radiolabelled N-acyl-2-amino-2-deoxy-hexoses, their incorporation into glycosphingolipids was shown.
authors.affiliation: Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kayser
authors.forename: C C
authors.initials: CC
authors.lastname: Geilen
authors.forename: C
authors.initials: C
authors.lastname: Paul
authors.forename: R
authors.initials: R
authors.lastname: Zeitler
authors.forename: W
authors.initials: W
authors.lastname: Reutter
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006028:Glycosphingolipids / Q000378:metabolism*; D006601:Hexoses / Q000096:biosynthesis / Q000378:metabolism*; D016716:PC12 Cells
chemical_list: D006028:Glycosphingolipids; D006601:Hexoses