Effect of benzimidazole drugs on the uptake of low molecular weight nutrients in Trichuris globulosa.
Thiabendazole (100 microM) and fenbendazole (250 microM) were found to inhibit U-14 C-glucose, (Na)-1-14C-palmitate and (Na)-1-14 C-acetate uptake markedly (P less than 0.001) in adult Trichuris globulosa. The inhibition was more pronounced with thiabendazole than with fenbendazole. 14C-Glucose was found to be Na(+)-dependent and a mediated process. Bile salts, viz. sodium cholate and sodium desoxycholate in the concentration range of 5-10 mM, were found to inhibit the uptake of 14C-glucose and 14C-palmitate (P less than 0.01) by the parasites. The optimum pH for (Na)-1-14C-palmitate and (Na)-1-14C-acetate uptake was 6.7 and 6.2, respectively while the optimum temperature for the uptake of these compounds was 37 degrees C.
Sarwal
R
R
Department of Zoology, Panjab University, Chandigarh, India.
Sanyal
S N
SN
Khera
S
S
D000085:Acetates / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D005273:Fenbendazole / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006041:Goats; D010168:Palmitates / Q000378:metabolism; D013827:Thiabendazole / Q000494:pharmacology*; D014258:Trichuris / Q000187:drug effects* / Q000378:metabolism
D000085:Acetates; D001647:Bile Acids and Salts; D010168:Palmitates; D005273:Fenbendazole; D005947:Glucose; D013827:Thiabendazole