title: IgE-mediated rhesus monkey asthma: natural history and individual animal variation.
abstract: This report reviews the 20 years of experience with naturally occurring allergy in dogs and allergic rhesus monkeys. The primate model of allergy is characterized by IgE-mediated cutaneous and respiratory responses to Ascaris antigen. Individual assessments of these monkeys have been carried out over several years and separate populations which are analogous to human IgE-mediated allergic populations defined. These populations are as follows: (1) monkeys which have persistent and consistent IgE-mediated cutaneous and asthmatic responses to Ascaris antigen; (2) monkeys which have cutaneous and airway reactivity to Ascaris antigen but in which the airway reactivity subsides and disappears analogous to a spontaneous remission human asthma, and (3) finally, there is a group of animals with cutaneous reactivity but no asthma analogous to humans with a similar absence of asthma. Within these groups the animals, like humans, have individual variations of severity.
authors.affiliation: Department of Medicine, Northwestern University Medical School, Chicago, Ill.
authors.forename: R
authors.initials: R
authors.lastname: Patterson
authors.forename: K E
authors.initials: KE
authors.lastname: Harris
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D001200:Ascaris; D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity; D004195:Disease Models, Animal; D005260:Female; D007073:Immunoglobulin E; D008253:Macaca mulatta; D008297:Male
chemical_list: D000947:Antigens, Helminth; D007073:Immunoglobulin E