PacB, a plasmid-encoded property which confers to E. coli K12 resistance to channel-forming colicins.
Plasmids belonging to incompatibility groups HI (subgroups HI2 and HI3 but not HI1) and HII but not from any other incompatibility group, confer to E. coli resistance against the bactericidal action of colicin B. Additionally it was demonstrated that this plasmid-encoded property, PacB, is not restricted to a specific colicin (colicin B) but also modifies bacterial susceptibility to the lethal activity determined by the channel-forming colicins A, B, E1, Ia, Ib, K, and N. PacB+ bacteria remain susceptible to colicins with other modes of action. This property appears to be highly conserved among the HI2 plasmids.
Rodriguez Lemoine
V
V
Centro de Biología Celular, Facultad de Ciencias, Universidad Central de Venezuela, Caracas.
D003087:Colicins / Q000494:pharmacology*; D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D011815:R Factors
D003087:Colicins