title: A case of histiocytic necrotizing lymphadenitis with bone marrow and skin involvement.
abstract: We report a case of histiocytic necrotizing lymphadenitis (HNL) with bone marrow extension in a 29-year-old male in which many large mononuclear cells infiltrated the bone marrow and mimicked malignant lymphoma. A lymph node biopsy confirmed the diagnosis of HNL. Immunohistologically, the infiltrating cells in the bone marrow were positive for lysozyme, LeuM1, Kp-1 and T-cell markers. The cells did not show haemophagocytosis. A skin biopsy from an accompanying facial skin rash revealed a proliferation of large cells similar to those observed in affected foci of the lymph node in subcutaneous tissue. The infiltrating cells were mainly lysozyme and Kp-1-positive histiocytes, some with phagocytosis of nuclear debris but none characteristic of haemophagocytosis. Transformed T-cells were also infiltrating.
authors.affiliation: First Department of Pathology, School of Medicine, Fukuoka University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sumiyoshi
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: M
authors.initials: M
authors.lastname: Takeshita
authors.forename: T
authors.initials: T
authors.lastname: Okamura
mesh_terms: D000328:Adult; D015415:Biomarkers; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008199:Lymphadenitis / Q000473:pathology*; D008297:Male; D009113:Muramidase / Q000032:analysis; D012867:Skin / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D015415:Biomarkers; D009113:Muramidase