[Comparative research on cellular immunostimulation by whole-body irradiation].
The effect of the cellular immune response by total body irradiation was investigated. The transplant survival (skin grafts) was determined as immune parameter. Donors were colony-bred Wistar rats and recipients were colony-bred Sprague-Dawley rats. The investigations were carried out with irradiated rats and with rats irradiated after thymectomy and/or adrenalectomy as well as with animals without irradiation. A single total-body irradiation (1 and 2 Gy) was administered. The skin graft survival in irradiated rats was significant shorter (radiogenic immunostimulation) than in unirradiated rats; there were no significant differences between the operated (thymectomy and/or adrenalectomy) and not operated animals. Including precedent examinations this radiogenic immunostimulation is caused by a relatively selective inactivation of T-suppressor cells.
Dietz
R
R
Service de Radiologie/Centre Hospitalier de Luxembourg.
Schwarze
G
G
D000315:Adrenalectomy; D000818:Animals; D003037:Cobalt Radioisotopes; D007111:Immunity, Cellular / Q000276:immunology / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology; D013934:Thymectomy; D014181:Transplantation Immunology / Q000276:immunology / Q000528:radiation effects*; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes
Vergleichende Untersuchungen über die zelluläre Immunstimulation durch Ganzkörperbestrahlung.