title: The relationship between clinical staging, oestrogen receptor status and silver-binding nucleolar organiser regions (AgNOR) in breast carcinoma.
abstract: Forty benign and 31 malignant breast tissues were examined using a one stage colloid-stabilising silver technique for argyrophilic nucleolar organiser regions (AgNOR). In 31 patients TNM staging was correlated to AgNOR score. There was a positive correlation with the T-stage and AgNOR score of the tumor (Spearman's rank correlation coefficient = 0.437). The N-stage and AgNOR score for breast cancers (n = 10) were inversely related, and there was a significant difference between the lymph node positive and negative groups (P less than 0.05). No significant relationship was identified between oestrogen receptor negative and positive groups and AgNOR score (P = 0.63). Mean regression analysis suggests that independent of the Bloom's grade, the AgNOR score is an indicator of tumour size.
authors.affiliation: University Surgical Unit, Southampton General Hospital, UK.
authors.forename: A K
authors.initials: AK
authors.lastname: Ohri
authors.forename: S K
authors.initials: SK
authors.lastname: Ohri
authors.forename: A
authors.initials: A
authors.lastname: Herbert
authors.forename: G
authors.initials: G
authors.lastname: Royle
authors.forename: I
authors.initials: I
authors.lastname: Taylor
mesh_terms: D001941:Breast Diseases / Q000378:metabolism / Q000473:pathology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011960:Receptors, Estrogen / Q000502:physiology*; D012044:Regression Analysis; D016622:Silver Staining
chemical_list: D011960:Receptors, Estrogen