Opsonophagocytosis of Pneumocystis carinii.
The interaction of Pneumocystis carinii purified from rat lungs with rat peritoneal macrophages and human circulating polymorphonuclear leucocytes was studied by amplified chemiluminescence and examination of stained cytospin preparations. A polyclonal rat antiserum to P. carinii was opsonic with both types of phagocyte. Complement had no opsonic properties alone but produced a synergic effect in combination with antibody.
Taylor
M B
MB
Department of Medical Microbiology, Wright Fleming Institute, St Mary's Hospital Medical School, London.
Phillips
M
M
Easmon
C S
CS
D000818:Animals; D000908:Antibodies, Fungal / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology*; D010587:Phagocytosis; D011010:Pneumocystis / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains
D000908:Antibodies, Fungal; D007106:Immune Sera; D009895:Opsonin Proteins; D003165:Complement System Proteins