Comparison of bone matrix-derived bone morphogenetic proteins from various animals.
Bone matrix-derived bone morphogenetic protein (BMP) was extracted from bovine, porcine, rabbit, Sprague-Dawley rat, and Wistar rat bone and purified. The purified fractions all had similar molecular weights and induced new bone in 3 weeks when implanted into muscle pouches of Wistar rats. Bone matrix-derived BMP is believed to consist of subunits and that of different animal origin to contain the same fraction with BMP activity.
Bessho
K
K
Department of Oral and Maxillofacial Surgery, Mie University School of Medicine, Japan.
Tagawa
T
T
Murata
M
M
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001681:Biological Assay; D001857:Bone Matrix / Q000737:chemistry*; D019485:Bone Morphogenetic Proteins; D002118:Calcium / Q000032:analysis; D002417:Cattle; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D004591:Electrophoresis, Polyacrylamide Gel; D006133:Growth Substances / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D008970:Molecular Weight; D010012:Osteogenesis / Q000187:drug effects; D011506:Proteins / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012967:Sodium Dodecyl Sulfate; D013045:Species Specificity; D013552:Swine
D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins; D012967:Sodium Dodecyl Sulfate; D000469:Alkaline Phosphatase; D002118:Calcium