title: Collagenous deposits on explanted intraocular lenses.
abstract: An immunohistochemical study of type I collagen in deposits on the surface of two intraocular lenses (IOLs) explanted from human eyes was conducted. Type I collagen-immunoreactive proteinaceous deposits with cells were found around the haptics of an iris-supported IOL. A few such deposits and what appeared to be macrophages were observed on the optic. A few cells (presumably macrophages and giant cells) were observed on a posterior chamber IOL, whereas proteinaceous deposits that reacted positively to the antibody were not identified. Type I collagen-immunoreactive deposits on the iris-supported IOL were thought to be the products of fibroblastic cells, originating from iris tissue, that attached directly to the haptics and helped stabilize the implant.
authors.affiliation: Department of Ophthalmology, Wakayama Medical College, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Saika
authors.forename: M
authors.initials: M
authors.lastname: Tamura
authors.forename: K
authors.initials: K
authors.lastname: Uenoyama
authors.forename: A
authors.initials: A
authors.lastname: Yamanaka
authors.forename: K
authors.initials: K
authors.lastname: Ohkubo
authors.forename: K
authors.initials: K
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Iwane
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000032:analysis*; D005347:Fibroblasts / Q000378:metabolism; D015726:Giant Cells / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D007910:Lenses, Intraocular; D008264:Macrophages / Q000378:metabolism; D008297:Male; D012086:Reoperation
chemical_list: D003094:Collagen