title: Smoke aldehyde component influences pulmonary edema.
abstract: The pulmonary edema of smoke inhalation is caused by the toxins of smoke and not the heat. We investigated the potential of smoke consisting of carbon in combination with either acrolein or formaldehyde (both common components of smoke) to cause pulmonary edema in anesthetized sheep. Seven animals received acrolein smoke, seven animals received a low-dose formaldehyde smoke, and five animals received a high-dose formaldehyde smoke. Pulmonary arterial pressure, pulmonary capillary wedge pressure, and cardiac output were not affected by smoke in any group. Peak airway pressure increased after acrolein (14 +/- 1 to 21 +/- 2 mmHg; P less than 0.05) and after low- and high-dose formaldehyde (14 +/- 1 to 21 +/- 1 and 20 +/- 1 mmHg, respectively; both P less than 0.05). The partial pressure of O2 in arterial blood fell sharply after acrolein [219 +/- 29 to 86 +/- 9 (SE) Torr; P less than 0.05] but not after formaldehyde. Only acrolein resulted in a rise in lung lymph flow (6.5 +/- 2.2 to 17.9 +/- 2.6 ml/h; P less than 0.05). Lung lymph-to-plasma protein ratio was unchanged for all three groups, but clearance of lymph protein was increased after acrolein. After acrolein, the blood-free extravascular lung water-to-lung dry weight ratio was elevated (P less than 0.05) compared with both low- and high-dose formaldehyde groups (4.8 +/- 0.4 to 3.3 +/- 0.2 and 3.6 +/- 0.2, respectively). Lymph clearance (ng/h) of thromboxane B2, leukotriene B4, and the sulfidopeptide leukotrienes was elevated after acrolein but not formaldehyde.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine (Pulmonary/Critical Care Unit), Massachusetts General Hospital, Boston.
authors.forename: C A
authors.initials: CA
authors.lastname: Hales
authors.forename: S W
authors.initials: SW
authors.lastname: Musto
authors.forename: S
authors.initials: S
authors.lastname: Janssens
authors.forename: W
authors.initials: W
authors.lastname: Jung
authors.forename: D A
authors.initials: DA
authors.lastname: Quinn
authors.forename: M
authors.initials: M
authors.lastname: Witten
mesh_terms: D000171:Acrolein / Q000633:toxicity; D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D005557:Formaldehyde / Q000633:toxicity; D006439:Hemodynamics / Q000187:drug effects; D008196:Lymph / Q000187:drug effects / Q000502:physiology; D011652:Pulmonary Circulation / Q000187:drug effects; D011654:Pulmonary Edema / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D012756:Sheep; D012906:Smoke / Q000009:adverse effects* / Q000032:analysis; D015208:Smoke Inhalation Injury / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D000447:Aldehydes; D012906:Smoke; D005557:Formaldehyde; D000171:Acrolein