Enkephalin- and serotonin-like immunoreactivity in the aortico-pulmonary paraganglia of the white-belly opossum Didelphis albiventris (Marsupialia).
Serial histological sections of the interatrial septum and basal heart vessels of the weaned and juvenile white-belly opossum (Didelphis albiventris) were obtained in order to study the presence of paraganglia and their content of regulatory peptides and serotonin. Paraganglion groups were mapped between the aorta and pulmonary arteries and close to the bifurcation of the pulmonary trunk and were found to contain cells with immunoreactivity to serotonin and to the neuroendocrine markers PGP 9.5 and NSE. When these paraganglia were tested for immunoreactivity to a battery of regulatory peptides, all were found to be positive for methionine-enkephalin, leucine-enkephalin and galanin. The hypothesis is raised that these peptides and serotonin, besides catecholamines, produced by these paraganglia may play a physiological role in the functions of the cardiovascular system of the white-belly opossum.
Gobbi
H
H
Department of Pathology, School of Medicine, Federal University of Minas Gerais, Brazil.
Barbosa
A J
AJ
Nogueira
J C
JC
Polak
J M
JM
Teixeira
V P
VP
Almeida
H O
HO
D000818:Animals; D002319:Cardiovascular System / Q000254:growth & development*; D004745:Enkephalins / Q000302:isolation & purification*; D007150:Immunohistochemistry; D008867:Microtomy; D009893:Opossums / Q000502:physiology*; D010233:Paraganglia, Chromaffin / Q000737:chemistry*; D010455:Peptides / Q000302:isolation & purification; D012701:Serotonin / Q000302:isolation & purification*; D014886:Weaning
D004745:Enkephalins; D010455:Peptides; D012701:Serotonin