Meniscal repair by fibrocartilage? An experimental study in the dog.
Longitudinal lesions in the avascular part of the dog's meniscus were repaired by implantation of a porous polyurethane. Ingrowing repair tissue was characterized by biochemical and immunological analysis. Histologically, repair tissue initially was composed of fibrous tissue containing type I collagen. After 3 months, fibrocartilaginous tissue developed inside the implants, whereas control defects only showed fibrous repair tissue. Both type I and II collagen, the major collagen types of normal meniscal fibrocartilage, could be detected in this newly formed fibrocartilage. It is concluded that fibrocartilage resembling normal meniscal tissue is formed and that longitudinal lesions can be healed after meniscal repair by implantation of a porous polymer.
Klompmaker
J
J
Department of Orthopaedic Surgery, University of Groningen, The Netherlands.
Jansen
H W
HW
Veth
R P
RP
Nielsen
H K
HK
de Groot
J H
JH
Pennings
A J
AJ
Kuijer
R
R
D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D002358:Cartilage, Articular / Q000502:physiology*; D003094:Collagen / Q000032:analysis; D004285:Dogs; D008592:Menisci, Tibial / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D011140:Polyurethanes; D019736:Prostheses and Implants
D011140:Polyurethanes; D003094:Collagen