title: Duplication mitosis in epithelio-glandular tissue.
abstract: As duplication mitosis occurs in epithelio-glandular tissue, a different concept of histological continuity and organization of this tissue is needed. In epithelio-glandular tissue, duplication mitosis play a role in histological continuity, while maturation mitosis leads to histological organization. Duplication mitosis reproduces stem cells for the cell turnover process. The life-span of the cell copies is limited to a certain period by maturation mitosis. Conservation of duplication mitosis and its alteration to maturation mitosis are regulated by a histological mechanism in the gland crypt, involving duplication and maturation factors. The result is that epithelio-glandular tissue is maintained within a prescribed physiological volume without excessive multiplication.
authors.affiliation: Hirata Hospital, Kochi City, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
mesh_terms: D004702:Endocrine Glands / Q000033:anatomy & histology / Q000166:cytology / Q000254:growth & development; D004847:Epithelial Cells; D004848:Epithelium / Q000033:anatomy & histology / Q000254:growth & development; D006801:Humans; D007422:Intestines / Q000033:anatomy & histology / Q000166:cytology* / Q000254:growth & development; D008938:Mitosis; D008954:Models, Biological; D013234:Stem Cells / Q000166:cytology