title: Approaches to the management of hypercholesterolaemia.
abstract: Patients with hypercholesterolaemia need to be carefully evaluated for underlying secondary or genetic causes. All such subjects require dietary advice. Those with total cholesterol levels persistently in excess of 6.5 mmol/l despite diet, and in the presence of multiple cardiac risk factors may need drug therapy. Drug therapy is likely to be life-long and the potential benefits need to be carefully assessed against the long-term safety of the agents employed.
authors.affiliation: Department of Clinical Chemistry, Queen Elizabeth Medical Centre, Birmingham, U.K.
authors.forename: C M
authors.initials: CM
authors.lastname: Florkowski
authors.forename: R
authors.initials: R
authors.lastname: Cramb
mesh_terms: D001629:Bezafibrate / Q000627:therapeutic use; D001647:Bile Acids and Salts / Q000378:metabolism; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D006937:Hypercholesterolemia / Q000628:therapy*; D009525:Niacin / Q000627:therapeutic use; D011341:Probucol / Q000627:therapeutic use
chemical_list: D001647:Bile Acids and Salts; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D009525:Niacin; D011341:Probucol; D001629:Bezafibrate