title: Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC.
abstract: The length of time after which persons infected with HIV-1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV-1-infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV-1-infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.
authors.affiliation: Department of Immuno-Allergology, Centre Hospitalier de Luxembourg.
authors.forename: F
authors.initials: F
authors.lastname: Hentges
authors.forename: A
authors.initials: A
authors.lastname: Hoffmann
authors.forename: F
authors.initials: F
authors.lastname: Oliveira de Araujo
authors.forename: R
authors.initials: R
authors.lastname: Hemmer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D000483:Alleles; D003181:Complement C4 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D015497:HIV-1; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D003181:Complement C4; D006680:HLA Antigens