Ataxic polyneuropathy and anti-Pr2 IgM kappa M proteinemia.
A case of ataxic neuropathy associated with IgM kappa M proteinemia is reported. Double filtration plasmapheresis effectively treated the neuropathy. The IgM kappa antibody had anti-Pr2 cold agglutinin activity. We demonstrated reactivities of the IgM kappa antibody to sialosyl paragloboside, sialosyl lactosaminyl paragloboside, GT1b, GD1a, GD1b, GM3 and GD3 on high-performance thin-layer chromatography immunostaining and enzyme-linked immunosorbent assay, which is previously unreported antigenic specificity of the M proteins in cases of paraproteinemic neuropathy. IgM M protein with anti-Pr2 cold agglutinin activity may play a pathogenetic role in peripheral nerve demyelination, because the target antigens of the M protein are present in myelin and possibly in endothelial cells of the peripheral nervous system.
Arai
M
M
Department of Neurology, Niigata University, Japan.
Yoshino
H
H
Kusano
Y
Y
Yazaki
Y
Y
Ohnishi
Y
Y
Miyatake
T
T
D001259:Ataxia / Q000209:etiology* / Q000628:therapy; D002240:Carbohydrate Sequence; D003450:Cryoglobulins / Q000032:analysis*; D003711:Demyelinating Diseases / Q000150:complications*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008081:Liposomes; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009431:Neural Conduction; D010265:Paraproteinemias / Q000150:complications*; D010956:Plasmapheresis; D012021:Reflex, Abnormal
D003450:Cryoglobulins; D005732:Gangliosides; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D008081:Liposomes