title: Spliced leader RNA sequences of Trypanosoma rangeli are organized within the 5S rRNA-encoding genes.
abstract: The spliced leader RNA(SL RNA)-encoding genes of the salivarian New World trypanosome, Trypanosoma rangeli, are organized within the 5S rRNA tandem repeats. Each repeat contains genes encoding an SL RNA and a 5S rRNA in the same orientation of transcription. This SL-5S organization is also present in the African trypanosome, Trypanosoma vivax. A similar association of SL and 5S genes has been observed in some nematodes, but has not been described previously in trypanosomatids.
authors.affiliation: Yale-MacArthur Center for Molecular Parasitology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: S
authors.initials: S
authors.lastname: Aksoy
authors.forename: G L
authors.initials: GL
authors.lastname: Shay
authors.forename: M S
authors.initials: MS
authors.lastname: Villanueva
authors.forename: C B
authors.initials: CB
authors.lastname: Beard
authors.forename: F F
authors.initials: FF
authors.lastname: Richards
mesh_terms: D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012326:RNA Splicing; D012341:RNA, Ribosomal, 5S / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment; D014158:Transcription, Genetic; D014345:Trypanosoma / Q000235:genetics*
chemical_list: D012341:RNA, Ribosomal, 5S; D004247:DNA