title: The surgical management of Melkersson-Rosenthal syndrome.
abstract: A triad of facial palsy, orofacial edema, and furrowed tongue constitutes an uncommon condition known as Melkersson-Rosenthal syndrome (MRS). We report on 14 patients with Melkersson-Rosenthal syndrome. Two patients had facial palsy, 12 had orofacial edema, and 1 patient had a furrowed tongue. Nine patients were treated medically. Intralesional steroid therapy had a 75 percent recurrence rate. Systemic steroid therapy resulted in remission in two of three patients. Surgical excision and reconstruction were carried out in five patients with chronic lip or eyelid edema. This provided relief in all cases. The etiology, clinical presentation, and histologic features are discussed. Three illustrative cases are presented. An algorithm is provided that guides the surgeon with regard to both the medical and surgical treatment of the patient with Melkersson-Rosenthal syndrome.
authors.affiliation: Division of Plastic Surgery, Sunnybrook Health Science Centre, Toronto, Ont., Canada.
authors.forename: L T
authors.initials: LT
authors.lastname: Glickman
authors.forename: J S
authors.initials: JS
authors.lastname: Gruss
authors.forename: B D
authors.initials: BD
authors.lastname: Birt
authors.forename: N
authors.initials: N
authors.lastname: Kohli-Dang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D005143:Eyelids / Q000601:surgery; D005260:Female; D006801:Humans; D008046:Lip / Q000601:surgery; D008297:Male; D008556:Melkersson-Rosenthal Syndrome / Q000175:diagnosis / Q000209:etiology / Q000601:surgery* / Q000628:therapy; D008875:Middle Aged