Allopurinol-induced nephrotoxicity: protection by the antioxidant, butylated hydroxytoluene.
The present study was conducted to provide morphological evidence for allopurinol-induced nephrotoxicity in rats and its prevention by the antioxidant butylated hydroxytoluene (BHT). The kidneys of male Sprague Dawley rats fed a diet containing 0.3% allopurinol for 25 days exhibited a marked increase in the weight (2.5 times) as compared to the controls (without allopurinol). Upon microscopic examination, extensive tubulo-interstitial injury leading to structural damage was observed. Feeding BHT (0.4%) along with 0.3% allopurinol brought about a remarkable amelioration of the nephrotoxicity. The results indicate that usage of BHT along with the antiurecemic drug, allopurinol, may be helpful in improving the allopurinol-induced nephrotoxicity observed in some gout patients.
Ansari
N H
NH
Department of Ophthalmology, Univeristy of Texas Medical Branch, Galveston 77550.
Rajaraman
S
S
D000493:Allopurinol / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D002084:Butylated Hydroxytoluene; D000493:Allopurinol