title: Sequences of primate insulin genes support the hypothesis of a slower rate of molecular evolution in humans and apes than in monkeys.
abstract: The chimpanzee and African green monkey insulin genes have been cloned and sequenced. These two sequences together with the previously reported sequences for the human and owl monkey insulin genes provide additional support for the hominoid-rate-slowdown hypothesis, i.e., a slower rate of nucleotide substitution in humans and apes than in monkeys. When these sequences and other primate sequences available for the relative-rate test were considered together, the substitution rate in the Old World monkey lineage was shown to be significantly higher than the rates in the human and chimpanzee lineages. This was true regardless of whether the eta-globin pseudogene was included in the analysis. Therefore, in contrast to the claim by Easteal, the hominoid-rate-slowdown is not unique to the eta-globin pseudogene but appears to be a rather general phenomenon. On average, the substitution rate at silent sites is about 1.5 times higher in the Old World monkey lineage than in the human and chimpanzee lineages.
authors.affiliation: Howard Hughes Medical Institute, Department of Medicine, University of Chicago.
authors.forename: S
authors.initials: S
authors.lastname: Seino
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
authors.forename: W H
authors.initials: WH
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002460:Cell Line; D002522:Chlorocebus aethiops; D004247:DNA; D014644:Genetic Variation; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000235:genetics*; D007700:Kinetics; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D011323:Primates / Q000235:genetics*; D013045:Species Specificity
chemical_list: D007328:Insulin; D004247:DNA