Reference values for apolipoproteins A-I and B in healthy subjects, by age.
We determined reference values of apolipoproteins A-I (apo A-I) and B (apo B) in serum from a population of 448 healthy subjects (265 men and 183 women, ages 18 to 61 years) by a kinetic immunonephelometric procedure. Frequency distributions of apo A-I were normal, whereas those of apo B were not and yielded asymmetrical curves. Thus, reference intervals for apo A-I were determined as mean +/- 2SD (1.08-1.89 g/L), but a nonparametric method was used for determining reference intervals for apo B (0.60-1.94 g/L). Apo B concentrations were significantly higher (P less than 0.001) in men than in women (0.63-2.01 g/L, mean 1.21 g/L; and 0.54-1.91 g/L, mean 1.08 g/L, respectively). No significant differences for apo A-I between men and women were observed. Concentrations of both proteins increased with age, but apo B increased more than apo A-I. We conclude that not only sex but also the age of the subjects must be considered in interpreting laboratory results for apolipoproteins.
Zunić
G
G
Institute for Medical Research, Military Medical Academy, Belgrade, Yugoslavia.
Jelić-Ivanović
Z
Z
Spasić
S
S
Stojiljković
A
A
Majkić-Singh
N
N
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood*; D016632:Apolipoprotein A-I / Q000032:analysis*; D001055:Apolipoproteins B / Q000097:blood*; D005260:Female; D006801:Humans; D007118:Immunoassay; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D012016:Reference Values; D012727:Sex Characteristics
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B