title: Serum gastrin concentrations in colorectal cancer patients.
abstract: Fasting serum gastrin concentrations were shown to be elevated in colorectal cancer patients compared with controls (P = 0.0037), which was mainly accounted for by a subgroup of patients who had significantly elevated levels. In cancer patients there was no difference in gastrin concentrations in blood taken from a tumour-draining mesenteric vein and from a peripheral vein at the time of colonic resection. Serum gastrin concentrations were significantly lower after apparently curative resection for colorectal cancer (P = 0.028), suggesting that the elevated serum gastrin seen in these patients may be due, at least in part, to secretion of gastrin by the tumour.
authors.affiliation: Department of Surgery, University Hospital, Nottingham.
authors.forename: R M
authors.initials: RM
authors.lastname: Charnley
authors.forename: W M
authors.initials: WM
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Stanley
authors.forename: D L
authors.initials: DL
authors.lastname: Morris
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D005215:Fasting / Q000097:blood; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008642:Mesenteric Veins; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D005755:Gastrins