title: [Chin neuropathy of neoplastic origin].
abstract: Three patients with mental neuropathy ("numb chin syndrome") secondary to systemic cancer are described. Two patients had malignant lymphoma and one a probable hypernephroma. In 2 patients, facial numbness was a presenting symptom of the malignancy. Investigations disclosed metastatic lesions of the mandible in one patient and cerebrospinal fluid was normal in 2 patients. Two patients died at 1 and 8 months respectively after onset of the neuropathy. Although benign in appearance, numb chin syndrome is most often, and sometimes initially, associated with visceral neoplasia or malignant hemopathy. It is a factor of poor prognosis. The pathogenesis is related either to metastasis of mandible, or neoplastic infiltration of the nerve itself.
authors.affiliation: Service de neurologie, Centre hospitalier universitaire vaudois, Lausanne.
authors.forename: C
authors.initials: C
authors.lastname: Henny
authors.forename: T
authors.initials: T
authors.lastname: Kuntzer
authors.forename: F
authors.initials: F
authors.lastname: Regli
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis; D002680:Chin / Q000294:innervation*; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000209:etiology*; D008339:Mandibular Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000556:secondary; D008479:Mediastinal Neoplasms / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D010292:Paresthesia / Q000209:etiology*
vernacular_title: Neuropathie mentonnière d'origine néoplasique.