Stress and brain histaminergic system: effects of weak electric foot-shock.
A weak electric foot-shock stressful stimulus (0.5 mA x 1 s x 5 times) significantly increases plasma corticosterone (CS) levels and modifies [3H]-histamine ([3H]-HA) binding site constants related to H2 receptors in rat cortical membranes. Progressive and total recovery of basal binding characteristics occurs 90 min later. A double-foot-shock stress procedure delays [3H]-HA binding characteristic recovery instead of strengthening stress effects. This finding is further evidence of involvement of the brain's histamine receptors in the response to mild stress.
Ghi
P
P
Institute of Pharmacology and Pharmacognosy, School of Pharmacy, University of Torino, Italy.
Blengio
M
M
Ferretti
C
C
Portaleone
P
P
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004558:Electric Stimulation; D006632:Histamine / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011970:Receptors, Histamine H2 / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*; D014316:Tritium
D011970:Receptors, Histamine H2; D014316:Tritium; D006632:Histamine