Bovine submandibular gland extracts interact with the human hemostasis factors.
Glycoconjugates were extracted from the bovine submandibular gland and their anticoagulant activity was tested on the blood coagulation of human beings. The methods employed demonstrated that the thromboelastographic parameters were only modified by the highest concentration of glycoconjugates. Activated Partial Thromboplastin Time (aPTT) and Thrombin Time (TT) were affected by dose-coupling response. Prothrombin Time (PT) and Reptilase Time (RT) were not modified.
Menghi
G
G
Dipartimento di Biologia M.C.A., Università di Camerino, Italy.
Piciotti
D
D
Ravaglia
F
F
D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001780:Blood Coagulation Tests; D002417:Cattle; D006001:Glycoconjugates / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D013363:Submandibular Gland / Q000378:metabolism*; D013916:Thrombelastography
D001779:Blood Coagulation Factors; D006001:Glycoconjugates