title: Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year.
abstract: Studies of cerebral oxidative metabolism were carried out by phosphorous magnetic resonance spectroscopy during the first week of life in 52 infants with clinical and/or biochemical evidence of birth asphyxia. 15 infants died and the 37 survivors were assessed by a wide range of neurodevelopmental tests at one year of age. The minimum recorded values for cerebral phosphocreatine/inorganic phosphate concentration ratio (an index of oxidative metabolism) were related to outcome. The results showed a significant relation between the extent of derangement of oxidative metabolism and the severity of adverse outcomes, including death, neurodevelopmental impairment and reduced head growth.
authors.affiliation: Department of Paediatrics, University College and Middlesex School of Medicine, London.
authors.forename: S C
authors.initials: SC
authors.lastname: Roth
authors.forename: A D
authors.initials: AD
authors.lastname: Edwards
authors.forename: E B
authors.initials: EB
authors.lastname: Cady
authors.forename: D T
authors.initials: DT
authors.lastname: Delpy
authors.forename: J S
authors.initials: JS
authors.lastname: Wyatt
authors.forename: D
authors.initials: D
authors.lastname: Azzopardi
authors.forename: J
authors.initials: J
authors.lastname: Baudin
authors.forename: J
authors.initials: J
authors.lastname: Townsend
authors.forename: A L
authors.initials: AL
authors.lastname: Stewart
authors.forename: E O
authors.initials: EO
authors.lastname: Reynolds
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000503:physiopathology*; D001724:Birth Weight / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism
chemical_list: D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate