[Primary hypothyroidism presenting with amenorrhea, galactorrhea, hyperprolactinemia and enlarged pituitary].
The combination of amenorrhea, galactorrhea, and hyperprolactinemia in a young woman usually suggests a prolactin-secreting adenoma of the anterior pituitary gland. Primary thyroid failure may also be associated with hyperprolactinemia, galactorrhea and suprasellar enlargement of the pituitary. 2 women, aged 23 and 28, respectively, presented with the latter syndrome. 1 was even a candidate for neurosurgery. However, because serum TSH and prolactin levels were elevated, thyroxin replacement therapy was started. It induced normal menses, galactorrhea stopped, and in follow-up CT scans the pituitary become normal in size. Hyperprolactinemia with secondary hypothyroidism, caused by a pituitary adenoma, must be distinguished from primary hypothyroidism, also a cause of hyperprolactinemia.
Tadmor
O P
OP
Gynecology Dept., Shaare Zedek Medical Center, Jerusalem.
Barr
I
I
Diamant
Y Z
YZ
D000236:Adenoma / Q000175:diagnosis; D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D003937:Diagnosis, Differential; D005260:Female; D005687:Galactorrhea / Q000209:etiology*; D006801:Humans; D006965:Hyperplasia; D006966:Hyperprolactinemia / Q000209:etiology*; D007037:Hypothyroidism / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D010902:Pituitary Gland / Q000473:pathology*; D010903:Pituitary Gland, Anterior; D010911:Pituitary Neoplasms / Q000175:diagnosis; D013974:Thyroxine / Q000627:therapeutic use
D013974:Thyroxine