title: Primary malignant lymphoma of the thyroid: a clinicopathological analysis.
abstract: A retrospective analysis of 70 patients with primary malignant lymphoma of the thyroid treated at this institute between 1965-1983 has been conducted. The clinicopathological features and prognostic factors have been studied. The mean age was 67.5 years and there was a marked female:male ratio of 8:1. A total of 32 (45.7%) Stage IE and 38 (54.3%) Stage IIE patients were identified. In 64 cases histological material was reviewed and classified employing the Kiel classification. All the tumors were of B cell lineage and the majority were follicle center cell type. A biopsy only was performed in 27 patients, lobectomy in 11 patients, subtotal thyroidectomy in 27 and macroscopic thyroidectomy in 5 patients. All patients were treated with radiotherapy. The overall 5-year survival was 42%, with 63% for Stage IE and 27% for Stage IIE. The corrected overall 5-year survival was 49% with 68% for Stage IE and 36% for Stage IIE. The corresponding overall relapse free survival was 42% with 60% for Stage IE, and 31% for Stage IIE. Factors of prognostic significance for relapse and survival were stage, radiotherapy dose, stridor, retrosternal extension and fixation.
authors.affiliation: Department of Radiotherapy and Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
authors.forename: J P
authors.initials: JP
authors.lastname: Logue
authors.forename: R J
authors.initials: RJ
authors.lastname: Hale
authors.forename: A L
authors.initials: AL
authors.lastname: Stewart
authors.forename: M B
authors.initials: MB
authors.lastname: Duthie
authors.forename: S S
authors.initials: SS
authors.lastname: Banerjee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery