title: Pharmacokinetics of single dose oral digoxin in patients with uncomplicated type II diabetes mellitus.
abstract: Digoxin pharmacokinetics was studied in eight patients with uncomplicated type II diabetes mellitus and seven healthy volunteers. After a single oral dose of digoxin (1 mg), the drug concentration was measured in the serum collected at different time intervals, using a radioimmunoassay method. The diabetics had a higher serum concentration of drug when compared to control. The clearance rate of digoxin was significantly reduced in diabetics when compared to healthy volunteers. The elimination half-life of about 22 hours in both groups is much less than that reported in Western data. Possible reasons for this discrepancy are discussed.
authors.affiliation: Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
authors.forename: B
authors.initials: B
authors.lastname: Gitanjali
authors.forename: C
authors.initials: C
authors.lastname: Adithan
authors.forename: R
authors.initials: R
authors.lastname: Raveendran
authors.forename: C H
authors.initials: CH
authors.lastname: Shashindran
authors.forename: S
authors.initials: S
authors.lastname: Chandrasekar
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004077:Digoxin