Spatial memory in aged rats: population heterogeneity and effect of levocarnitine acetyl.
The existence in a population of aging rats of classes that display a different performance in the Morris water-maze test was investigated by cluster analysis procedure. These classes identified at 18 months of age showed a different response to levocarnitine acetyl and had a different behavioral profile when tested at 25 months of age. These findings demonstrate the need for an alternative interpretation of variability in animal populations as measured by the standard statistical analyses. The data analysis strategy we propose here will allow for the use of variability as a useful source of information.
Ghirardi
O
O
Institute for Research on Senescence, Sigma-Tau Pomezia, Rome, Italy.
Giuliani
A
A
Caprioli
A
A
Ramacci
M T
MT
Angelucci
L
L
D000108:Acetylcarnitine / Q000494:pharmacology*; D000375:Aging / Q000523:psychology*; D000818:Animals; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013028:Space Perception / Q000502:physiology*
D000108:Acetylcarnitine