Lanomycin and glucolanomycin, antifungal agents produced by Pycnidiophora dispersa. I. Discovery, isolation and biological activity.
The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14 alpha-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.
O'Sullivan
J
J
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, N.J. 08543-4000.
Phillipson
D W
DW
Kirsch
D R
DR
Fisher
S M
SM
Lai
M H
MH
Trejo
W H
WH
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D004875:Ergosterol / Q000096:biosynthesis; D005260:Female; D005285:Fermentation; D051379:Mice; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011714:Pyrans; C074358:lanomycin; C074359:glucolanomycin; D004875:Ergosterol