The arthritis of ulcerative colitis: clinical and genetic aspects.
Seventy-nine consecutive patients with active ulcerative colitis were studied to establish the prevalence and clinical features of articular involvement. HLA typing for A and B loci was performed. Forty-nine patients showed an articular involvement (62%). Three different clinical patterns were identified: ankylosing spondylitis occurring in 20 subjects; peripheral arthritis in 15; unclassifiable spondylitis in 14. When compared to the general population in our area, patients with colitis showed a significantly higher prevalence of the HLA-A1 (p less than 0.005), B21 (p less than 0.001) and B27 (p less than 0.05); among patients with colitis, those with arthritis revealed higher frequency of HLA-B27 (p less than 0.05). Our study reveals a high prevalence of unclassifiable spondylitis during ulcerative colitis, and suggests a new approach to the classification of seronegative spondarthritis.
Scarpa
R
R
Department of Internal Medicine, 2nd Medical School, University of Naples, Italy.
del Puente
A
A
D'Arienzo
A
A
di Girolamo
C
C
della Valle
G
G
Panarese
A
A
Lubrano
E
E
Oriente
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000453:epidemiology / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013166:Spondylitis / Q000209:etiology; D013167:Spondylitis, Ankylosing / Q000209:etiology
D006680:HLA Antigens