The role of protein kinase C in migration of rat glioma cells from spheroid cultures.
The role of protein kinase C in migration of tumor cells from spheroid cultures was investigated using parental rat glioma cells and their TPA resistant counterparts. These two lines differed in their PKC content as judged by the histone phosphorylation method. Also 4 days of treatment with IRA led to PKC down-regulation. Cells having a drastically decreased PKC level migrated better than those having a normal PKC content.
Janik
P
P
Department of Tumor Biology, Cancer Center Institute of Oncology, Warsaw, Poland.
Szaniawska
B
B
Miloszewska
J
J
Pietruszewska
E
E
Kowalczyk
D
D
D000818:Animals; D001932:Brain Neoplasms / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement; D005910:Glioma / Q000503:physiopathology*; D011493:Protein Kinase C / Q000378:metabolism*; D051381:Rats; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate