Effects of intracarotid infusion of neuropeptide Y on cerebral blood flow in rats.
Neuropeptide Y (NPY) was continuously administered to Wistar rats intracarotidly via the external carotid artery and local cerebral blood flow (LCBF) was measured by a quantitative autoradiography using [14C]iodoantipyrine. A remarkable reduction in LCBF was observed in the NPY infused hemisphere. This depression was irregular and was particularly evident in the hippocampus, selective thalamic nuclei and the cerebral cortex.
Okazaki
S
S
Department of Neurosurgery, Asahikawa Medical College, Japan.
Sako
K
K
Yonemasu
Y
Y
D000818:Animals; D000983:Antipyrine / Q000031:analogs & derivatives; D001345:Autoradiography; D002250:Carbon Radioisotopes; D002339:Carotid Arteries; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D008297:Male; D009478:Neuropeptide Y / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D009478:Neuropeptide Y; D000983:Antipyrine; C008135:iodoantipyrine