Cortical sensory representation of the human hand: size of finger regions and nonoverlapping digit somatotopy.
Findings differ on cortical representation of fingers between human and animal studies, and on digit somatotopy among human studies. To resolve these differences, we mapped cortical sensory representation of each of the five digits and of median and ulnar nerves in three patients, using focal peripheral electrical shock stimuli. We compared locations and sizes of cortical regions among digits and nerves, using the model of a current dipole in a sphere applied to electrocorticography from subdural grids. Cortical representation was larger for the index finger than for the little finger and for the middle finger than for the ring finger, which are similar to findings in the monkey but different from Penfield's classic sensory homunculus. The thumb was larger than the middle finger, as in the homunculus. There was nonoverlapping somatotopy of all digits in each patient. These findings demonstrate a previously unrecognized similarity of cortical sensory organization of the fingers between humans and other primates.
Sutherling
W W
WW
Department of Neurology, University of California, Los Angeles.
Levesque
M F
MF
Baumgartner
C
C
D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000503:physiopathology / Q000601:surgery; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005385:Fingers / Q000294:innervation; D006225:Hand / Q000294:innervation* / Q000502:physiology; D006801:Humans; D011930:Reaction Time