title: Ergot pharmacology and alternative delivery systems for ergotamine derivatives.
abstract: Dihydroergotamine mesylate (DHE) has been used in migraine therapy since the 1940s. Renewed interest in its use has been kindled by research in receptor pharmacology and by efficacy of DHE-45 in breaking the cycle of chronic daily headache. Nasal and oral routes of administration may widen the applicability of DHE.
authors.affiliation: San Francisco Headache Clinic, University of California Medical Center 94109.
authors.forename: J
authors.initials: J
authors.lastname: Goldstein
mesh_terms: D004087:Dihydroergotamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004333:Drug Administration Routes; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*
chemical_list: D004087:Dihydroergotamine