title: The protective effect of early intraoperative injection of viscoelastic material in trabeculectomy.
abstract: In a prospective study, we evaluated the effect of intracameral injection of sodium hyaluronate (HA) in trabeculectomy on short- and long-term results, including the effect on the corneal endothelium. Twenty-two patients were randomly assigned into two groups: group A, consisting of 11 patients, underwent standard trabeculectomy; in group B (11 patients), additionally, HA was injected into the anterior chamber immediately following paracentesis in an attempt to minimize shallowing of the chamber after the subsequent trabeculectomy. Both groups had comparable age distributions, preoperative intraocular pressures (IOPs), preoperative endothelial cell counts, postoperative IOPs after 3 months, and glaucoma medication indices. The reduction in the number of endothelial cells after 1 month was significantly greater in group A than in group B (16.1% vs 6.7%). Also, significantly more shallow anterior chambers occurred in group A (three eyes vs one eye). However, 1 day postoperatively, the average IOP was 16.4 mm Hg in group A, as compared with 25 mm Hg in group B. Thus, although HA, injected early in trabeculectomy, appeared to protect against corneal endothelial loss and flat anterior chamber, it also seemed to be associated with early IOP spikes.
authors.affiliation: Maurice and Gabriela Goldschleger Eye Institute, Tel Aviv University, Sackler School of Medicine, Tel Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Barak
authors.forename: A
authors.initials: A
authors.lastname: Alhalel
authors.forename: R
authors.initials: R
authors.lastname: Kotas
authors.forename: S
authors.initials: S
authors.lastname: Melamed
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000473:pathology; D002452:Cell Count; D003316:Corneal Diseases / Q000517:prevention & control; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000188:drug therapy / Q000601:surgery*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D007429:Intraocular Pressure; D007430:Intraoperative Care; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D014130:Trabeculectomy
chemical_list: D006820:Hyaluronic Acid