The effects of N-methyl-D-aspartate antagonism on the inspiratory activities of developing animals.
In developing kittens, antagonism of N-methyl-D-aspartate receptors by systemic injections of MK-801 produced: (a) blockage of the inspiratory off-switch, prolonging phrenic and hypoglossal discharges; (b) age-dependent changes of sympathetic inspiratory discharges, elimination of inspiratory-related discharges in animals less than or equal to 36 days old and prolongation of these discharges in older animals; (c) suppression of high-frequency oscillations in phrenic activities.
Sica
A L
AL
Department of Pediatrics, Schneider Children's Hospital, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
Siddiqi
Z A
ZA
Pisana
F M
FM
D000375:Aging / Q000502:physiology; D000818:Animals; D002415:Cats; D003655:Decerebrate State; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005260:Female; D007002:Hypoglossal Nerve / Q000187:drug effects / Q000502:physiology; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D010791:Phrenic Nerve / Q000502:physiology; D012119:Respiration / Q000187:drug effects*; D013238:Stereotaxic Techniques
D016202:N-Methylaspartate; D016291:Dizocilpine Maleate