title: Familial occurrence of pruritic urticarial papules and plaques of pregnancy.
abstract: BACKGROUND
  The occurrence of pruritic urticarial papules and plaques of pregnancy (PUPPP) was noted in four women with unusual family relationships.
  
  
  OBJECTIVE
  The purpose of the study was to document the occurrence of PUPPP in these families and to make observations on their possible relevance.
  
  
  METHODS
  Case reports of the four patients are detailed. Histologic and HLA studies are recorded.
  
  
  RESULTS
  In both families, sisters were married to brothers. A common paternal influence is suggested.
  
  
  CONCLUSIONS
  We postulate that PUPPP may be a maternal response to a circulating paternal factor for which tolerance develops in subsequent pregnancies.
authors.affiliation: University of the Witwatersrand Medical School, Johannesburg, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Weiss
authors.forename: P
authors.initials: P
authors.lastname: Hull
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D004200:Diseases in Twins / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D010375:Pedigree; D011247:Pregnancy / Q000235:genetics; D011248:Pregnancy Complications / Q000473:pathology*; D011537:Pruritus / Q000235:genetics* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014581:Urticaria / Q000235:genetics* / Q000473:pathology
chemical_list: D006680:HLA Antigens