Enalapril-induced anemia in two kidney transplant recipients.
Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication. Hemoglobin levels normalized after administration of enalapril was stopped. In one patient, it was demonstrated that the discontinuation of enalapril was followed by a decrease in renal blood flow and a significant increase in the plasma erythropoietin levels that preceded the rise in hemoglobin. These observations are consistent with the hypothesis that angiotensin-converting enzyme inhibition may cause anemia by increasing renal blood flow and consequently decreasing erythropoietin levels.
Graafland
A D
AD
Department of Nephrology and Transplantation, Leiden University Hospital, The Netherlands.
Doorenbos
C J
CJ
van Saase
J C
JC
D000328:Adult; D000740:Anemia / Q000139:chemically induced*; D004656:Enalapril / Q000009:adverse effects*; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology
D004921:Erythropoietin; D004656:Enalapril