Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.
A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.
Walker
C
C
Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
Goldsworthy
T L
TL
Wolf
D C
DC
Everitt
J
J
D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D004128:Dimethylnitrosamine; D004195:Disease Models, Animal; D007672:Kidney Cortex / Q000473:pathology; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D051381:Rats; D011922:Rats, Mutant Strains
D004128:Dimethylnitrosamine