Does a critical hemodynamic situation develop from right ventriculotomy and free wall infarct or from small changes in dysfunctional right ventricle afterload?
An experimental model for right ventricle free wall infarct associated with double ventriculotomy and tricuspid insufficiency was created to evaluate whether right ventricle failure can cause profound refractory heart failure or whether modifications in right ventricular afterload are more influential in this regard. In our model, the left ventricle, interventricular septum and right atrial wall were maintained intact and pulmonary banding made it possible to modify right ventricular afterload during the experiment. The results of our study showed that pure right ventricular failure does affect the hemodynamic state negatively, but it is not itself, a cause of death in dogs. A slight increase in the dysfunctional right ventricular afterload produced a profound deterioration in the hemodynamic state that required pulmonary artery debanding within no more than 10 minutes.
Fantidis
P
P
Experimental Surgery Department, Hospital La Paz, Facultad de Medicina, Universidad Autonoma, Madrid, Spain.
Castejon
R
R
Fernández Ruiz
A
A
Madero-Jarabo
R
R
Cordovilla
G
G
Sanz Galeote
E
E
D000818:Animals; D003250:Constriction; D004285:Dogs; D006333:Heart Failure / Q000209:etiology*; D006352:Heart Ventricles / Q000601:surgery*; D006439:Hemodynamics; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology*; D011651:Pulmonary Artery / Q000503:physiopathology; D014262:Tricuspid Valve Insufficiency / Q000150:complications / Q000503:physiopathology*; D016278:Ventricular Function, Right