title: Albino-type misrouting of the optic nerve fibers not found in dissociated vertical deviation.
abstract: It has been suggested that albinolike misrouting of the visual pathway occurs in patients with dissociated vertical deviation (DVD). We re-examined this contention in ten DVD patients using visually evoked potentials. Full-field monocular pattern-onset checkerboard stimulation was employed. The visually evoked potentials were recorded simultaneously from both occipital lobes. Their differential activity during stimulation of the right eye was compared with that obtained during stimulation of the left. We found no predominance of crossed projection in any of the DVD cases. The results in nine normal subjects were similar. In 13 albino patients, however, there was a relative positivity in the contralateral hemisphere about 100 ms after pattern-onset, which reconfirmed predominance of the crossed projection. Possible artifacts are discussed that may have led to the assumption of misrouting in DVD in two previous reports.
authors.affiliation: Universitäts-Augenklinik, Abteilung Neuroophthalmologie und Schielbehandlung, Freiburg, Federal Republic of Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bach
authors.forename: G
authors.initials: G
authors.lastname: Kommerell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016117:Albinism, Ocular / Q000503:physiopathology*; D016115:Albinism, Oculocutaneous / Q000503:physiopathology*; D002648:Child; D005074:Evoked Potentials, Visual; D006801:Humans; D008875:Middle Aged; D009900:Optic Nerve / Q000503:physiopathology*; D010364:Pattern Recognition, Visual; D013285:Strabismus / Q000503:physiopathology*; D014795:Visual Pathways