N-acyl 3-alkylidenyl- and 3-alkyl azetidin-2-ones: a new class of monocyclic beta-lactam antibacterial agents. 1. Structure-activity relationships of 3-isopropylidene and 3-isopropyl analogs.
The synthesis and antibacterial activity of a series of N-acyl 3-isopropylidenyl- and 3-isopropyl 2-azetidinones having potent in vitro antibacterial activity, particularly against anaerobic organisms, is described. A distinguishing structural feature of these compounds is the lack of any ionizable moiety appendant to the lactam nitrogen.
Brickner
S J
SJ
Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
Gaikema
J J
JJ
Zurenko
G E
GE
Greenfield
L J
LJ
Manninen
P R
PR
Ulanowicz
D A
DA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams