title: Cellular automaton model of ventricular fibrillation.
abstract: A theoretical analysis of ventricular fibrillation and the requirements for fibrillation are performed using a discrete element neighborhood (cellular automaton) model of ventricular conduction. The model is configured as a 2500 element rectangular grid on the surface of a cylinder. It is shown that vulnerability to fibrillation is strongly influenced by excited state duration which primarily determines the nature of the underlying reentry activity. As excited state duration is increased fibrillation changes from "coarse" macroreentrant activity to the more chaotic "fine" fibrillation sustained by multiple wavelets of microreentry. In general, defibrillation is achieved by a stimulus strong enough to depolarize the majority of relative refractory elements. The threshold for defibrillation is increased for the more irregular microreentrant fibrillation.
authors.affiliation: Department of Electrical and Electronic Engineering, University of Ulster, Co. Antrim, Northern Ireland.
authors.forename: R H
authors.initials: RH
authors.lastname: Mitchell
authors.forename: A H
authors.initials: AH
authors.lastname: Bailey
authors.forename: J
authors.initials: J
authors.lastname: Anderson
mesh_terms: D003198:Computer Simulation; D004554:Electric Countershock; D004562:Electrocardiography; D006329:Heart Conduction System / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D014693:Ventricular Fibrillation / Q000503:physiopathology* / Q000628:therapy