title: Efficacy of ivermectin as an anthelmintic in leopard frogs.
abstract: Ivermectin administered cutaneously at dosages of 2 mg/kg of body weight eliminated nematode infections in leopard frogs. Three clinical trials were conducted. In the first trial, 5 groups of 11 frogs were given ivermectin IM at dosages of 0, 0.2, 0.4, 2, or 20 mg/kg. All frogs given ivermectin IM at dosages of 2.0 mg/kg or greater died. In trial 2, 44 frogs, allotted to 5 groups, were given ivermectin cutaneously at 0, 0.2, 2, or 20 mg/kg. Cutaneously administered ivermectin was not toxic at dosages up to 20 mg/kg. In trial 3, nematode infections were eliminated in all 10 frogs treated cutaneously with ivermectin at 2.0 mg/kg.
authors.affiliation: Lincoln Park Zoological Gardens, Chicago, IL 60614-3895.
authors.forename: J
authors.initials: J
authors.lastname: Letcher
authors.forename: M
authors.initials: M
authors.lastname: Glade
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000469:parasitology; D007273:Injections, Intramuscular / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010243:Paralysis / Q000139:chemically induced / Q000662:veterinary; D011894:Rana pipiens / Q000469:parasitology*; D012869:Skin Absorption
chemical_list: D007559:Ivermectin