Fluoxetine-induced psoriasis.
BACKGROUND
A number of medications have been reported to induce psoriasis. We report two cases of fluoxetine-related psoriasis and discuss similarities between lithium-, trazodone hydrochloride-, and fluoxetine-induced psoriasis.


METHODS
Two women being treated for depression with fluoxetine developed psoriasis after 6 and 12 months' exposure. This time frame is clinically similar to that observed with lithium-induced psoriasis.


CONCLUSIONS
The occurrence of lithium- and fluoxetine-induced psoriasis may not be random. Both drugs modulate serotonergic function, a factor that may contribute to the pathophysiology of psoriasis. If a patient on acute or long-term fluoxetine therapy develops psoriasis, the drug should be considered as a possible etiologic agent.
Hemlock
C
C
Mount Sinai School of Medicine, New York, NY.
Rosenthal
J S
JS
Winston
A
A
D000328:Adult; D003863:Depression / Q000188:drug therapy; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects*; D006801:Humans; D008094:Lithium / Q000009:adverse effects; D008875:Middle Aged; D011565:Psoriasis / Q000139:chemically induced*
D005473:Fluoxetine; D008094:Lithium