Cardiomyoplasty does not preclude heart transplantation.
Stimulated skeletal muscle grafts have been proposed to improve left ventricle function in patients with severe myocardial failure. In 1 particular case reported here, however, the postoperative functional improvement was only transient and disabling heart failure recurred after 9 months in spite of a vigorous latissimus muscle contraction. Heart transplantation was proposed to this patient and performed successfully. Technically, the key to heart removal depends on the retrograde dissection of the ventricular cavities, starting from the right atrioventricular groove. The intraoperative observations confirmed the viability of the latissimus dorsi muscle, inefficient on a highly dilated cardiomyopathy. Histopathological examination of the latissimus dorsi muscles showed that the transformation process of the stimulated muscle was good. Thus, severe cardiac dilatation seems to be one of the limitations of cardiomyoplasty. Cardiomyoplasty, when it fails, does not preclude heart transplantation. The histochemical studies confirm the electrophysiologic principle of cardiomyoplasty in humans.
Jegaden
O
O
Hôpital Cardiovasculaire et Pneumologique, Lyon, France.
Delahaye
F
F
Montagna
P
P
Vedrinne
C
C
Blanc
P
P
Rossi
R
R
Tabib
A
A
Saint Pierre
A
A
Delahaye
J P
JP
Mikaeloff
P H
PH
D001243:Assisted Circulation / Q000379:methods; D002303:Cardiac Output, Low / Q000209:etiology / Q000601:surgery; D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000637:transplantation*; D011183:Postoperative Complications / Q000601:surgery