title: Proximal femur density in type 1 and 2 diabetic patients.
abstract: This study reports on the proximal femur mineral content in 36 Type 1 and 60 Type 2 diabetic patients. Bone mass measurements were performed in the neck, Ward's triangle and in the trochanteric area of the femur, using dual-photon absorptiometry with 153Gd. Bone mineral density (BMD) was significantly decreased in Type 1 diabetic men and women as well in Type 2 men, when compared with a non diabetic matched population. In Type 1 men, neck and Ward's triangle densities were reduced from 0.94 +/- 0.05 to 0.86 +/- 0.11 (p = 0.007) and from 0.87 +/- 0.10 to 0.74 +/- 0.14 g.cm-2 (p = 0.011), respectively. In Type 1 women, BMD was reduced from 0.97 +/- 0.10 to 0.90 +/- 0.10 g.cm-2 (p = 0.023) in the femoral neck. In Type 2 men, BMD in Ward's triangle was also significantly lower than in controls: 0.69 +/- 0.14 vs 0.76 +/- 0.19 g.cm-2, respectively (p = 0.001). In contrast, no bone loss was observed in a group of Type 2 overweight diabetic women. No statistical correlation was observed between bone loss and age, duration of diabetes, body mass index, C-peptide levels, daily insulin doses, HbA1 and the presence of diabetic complications. In conclusion, long-standing Type 1 diabetic men and women and Type 2 diabetic men have a decrease in the proximal femur bone mass. Type 2 diabetic women appear to be protected from diabetic osteopenia.
authors.affiliation: Division of Endocrinology, University Hospital UCL of Mont-Godinne, Yvoir, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Buysschaert
authors.forename: F
authors.initials: F
authors.lastname: Cauwe
authors.forename: J
authors.initials: J
authors.lastname: Jamart
authors.forename: C
authors.initials: C
authors.lastname: Brichant
authors.forename: P
authors.initials: P
authors.lastname: De Coster
authors.forename: A
authors.initials: A
authors.lastname: Magnan
authors.forename: J
authors.initials: J
authors.lastname: Donckier
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015519:Bone Density; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000503:physiopathology; D005260:Female; D005269:Femur; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012727:Sex Characteristics
chemical_list: D002096:C-Peptide; D006442:Glycated Hemoglobin