title: [In-vitro activity pattern of gallbladder muscle tissues in patients with and without gallstones--variable response to cholecystokinin, motilin and neurotensin].
abstract: Data about gallbladder motility in stone disease and stone free conditions are discussed controversially. This study is aimed at to evaluate in vitro the responses of human gallbladder muscle stripes to cholecystokinin, motilin and neurotensin. Following the results, a stratification of the "stone-disease-group" seems to be necessary: 41% of the gallbladders (stone disease) demonstrate a deep reduction in contractility to cholecystokinin ("non-contractors"), whereas 59% of the gallbladders contract in the same pattern like the controls ("contractors"). Interestingly, the majority of the gallbladders in the "contractor" group demonstrate a high spontaneous activity which is absent in stone free gallbladders. Motilin and neurotensin either do not induce any effect.
authors.affiliation: Zentren der Chirurgie, Universitätsklinikum Frankfurt/M.
authors.forename: E
authors.initials: E
authors.lastname: Hanisch
authors.forename: J
authors.initials: J
authors.lastname: Hawlicek
authors.forename: R
authors.initials: R
authors.lastname: Jakobi
authors.forename: S
authors.initials: S
authors.lastname: Falk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002766:Cholecystokinin / Q000494:pharmacology; D002769:Cholelithiasis / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005704:Gallbladder / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009037:Motilin / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009496:Neurotensin; D010528:Peristalsis
chemical_list: D009496:Neurotensin; D009037:Motilin; D002766:Cholecystokinin
vernacular_title: In-vitro-Aktivitätsmuster der Gallenblasenmuskulatur von Steinträgern und Nicht-Steinträgern--Differenzierte Antwort auf Cholezystokinin, Motilin und Neurotensin.