Tirilazad mesylate protects vitamins C and E in brain ischemia-reperfusion injury.
Brain concentrations of the antioxidant vitamins C and E decreased following unilateral carotid occlusion and reperfusion for 2 or 24 h in gerbils. Administration of the 21-aminosteroid inhibitor of lipid peroxidation, tirilazad mesylate (U74006F), prevented the decrease in level of both of these vitamins following 2 h of reperfusion. After 24 h of reperfusion, however, alpha-tocopherol (vitamin E) continued to be protected, but ascorbic acid (vitamin C) showed a pronounced decrease in content. The changes in concentrations of these vitamins are consistent with U74006F acting to inhibit peroxidation in the CNS by scavenging of lipid peroxyl radicals and suggest that, in the presence of this agent, injury-induced depletion of ascorbic acid may occur without irreversible tissue damage.
Sato
P H
PH
Department of Pharmacology, Michigan State University, East Lansing 48824.
Hall
E D
ED
D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis / Q000378:metabolism*; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry; D002545:Brain Ischemia / Q000378:metabolism*; D005849:Gerbillinae; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors*; D008297:Male; D011281:Pregnatrienes / Q000494:pharmacology*; D015427:Reperfusion Injury / Q000378:metabolism*; D013997:Time Factors; D014810:Vitamin E / Q000032:analysis / Q000378:metabolism*
D008054:Lipid Peroxides; D011281:Pregnatrienes; D014810:Vitamin E; D001205:Ascorbic Acid; C053355:tirilazad