title: [Hyperalphalipoproteinemia: causes of therapeutic errors in primary care].
abstract: OBJECTIVE
  To consider using request for cholesterol together with high density lipoproteins (cHDL) before any hypolipemic treatment.
  
  
  METHODS
  Three clinical observations.
  
  
  METHODS
  General medicine surgery of the La Orden Health Centre in Huelva.
  
  
  METHODS
  Patients diagnosed with hyperalphalipoproteinemia in whom the total cholesterol (Ct) rate did not lower after treatment with hypolipemic drugs and diet.
  
  
  RESULTS
  In all patients, the Ct, triglyceride (TG), cHDL, cholesterol together with low density lipoproteins (cLDL), very low density lipoproteins (cVLDL) and apoprotein A1 (Apo A1) were determined using enzymatic, ultracentrifuge and immunonephelometric methods. The cHDL reference value was 30-70 and 30-85 mg/dl in males and females respectively. The results obtained in the three observations were: Ct (288, 292 and 284 mg/dl) cHDL (118, 122 and 114 mg/dl) Apo A1 (2.44, 2.36 and 2.02 milligrams) which were all high, whereas cLDL and cVLDL and the TG obtained normal results.
  
  
  CONCLUSIONS
  We consider it necessary to carry out a cHDL and cLDL study before starting any type of hypolipemic treatment. The clinical importance of correct diagnosis of hyperalphalipoproteinemia is obvious, as hypercholesterolemia can be treated with hypolipemic drugs in spite of cLDL being normal. The cases described underline the importance of basing decisions on the treatment of hypercholesterolemia in cLDL figures and not in Ct figures.
authors.affiliation: Centro de Salud La Orden, Huelva.
authors.forename: E
authors.initials: E
authors.lastname: Márquez Contreras
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez Peña
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy; D006951:Hyperlipoproteinemias / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011320:Primary Health Care; D014280:Triglycerides / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol
vernacular_title: Hiperalfalipoproteinemias: causas de errores terapéuticos en atención primaria.