Bioconversion of tamoxifen by microbes.
Screening studies of tamoxifen (TAM) have shown that only one culture, Streptomyces rimosus ATCC 2234 was able to metabolize tamoxifen to 4-hydroxy tamoxifen (OHT) which was obtained in a 10% yield and chemically identified by 2 D nmr spectroscopy. A number of microorganisms were capable of biotransforming TAM to tamoxifen-N-oxide (TNO), and desmethyltamoxifen (DMT). The chemical identity of the isolated metabolites was achieved using gas chromatography/mass spectrometry and different nmr spectroscopic techniques.
el-Sharkawy
S H
SH
Department of Pharmacognosy, University of Mississippi, Oxford 38677.
D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D005658:Fungi / Q000378:metabolism*; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000493:pharmacokinetics*
D013629:Tamoxifen; C016601:afimoxifene; C028787:N-desmethyltamoxifen