Impaired levodopa response in Parkinson's disease during melanoma therapy.
A patient with melanoma and sporadic positive melanuria developed Parkinson's disease. Treatment with levodopa failed to modify tumoral progress. However, during chemotherapy with dacarbazine, the patient experienced a significant impairment to levodopa response.
Merello
M
M
Fleni (Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia), Buenos Aires, Argentina.
Esteguy
M
M
Perazzo
F
F
Leiguarda
R
R
D000328:Adult; D003606:Dacarbazine / Q000009:adverse effects* / Q000627:therapeutic use; D004298:Dopamine / Q000097:blood; D004347:Drug Interactions; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008543:Melanins / Q000652:urine; D008545:Melanoma / Q000150:complications* / Q000188:drug therapy; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000150:complications* / Q000188:drug therapy
D008543:Melanins; D007980:Levodopa; D003606:Dacarbazine; D004298:Dopamine