title: Selective abortion for familial Alzheimer disease?
abstract: Advances in human genetics will soon allow prenatal diagnosis of genetic conditions in the fetus that range from trivial to devastating. This commentary explores the concept of severity in genetic diseases and decisions regarding selective abortion. Familial Alzheimer disease is used as a model for the analysis of ethical issues raised by prenatal diagnosis and the subsequent termination of pregnancy. The genetics of the disease has yet to be elucidated, but this condition may be amenable to prenatal diagnosis in the near future, at least in some families. Abortion is a choice open to women in the United States; however, it is still desirable to discuss on purely ethical grounds pregnancy termination in the case of late-onset but severe diseases.
authors.affiliation: Center for Biomedical Ethics, Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: S G
authors.initials: SG
authors.lastname: Post
authors.forename: J R
authors.initials: JR
authors.lastname: Botkin
authors.forename: P
authors.initials: P
authors.lastname: Whitehouse
mesh_terms: D000025:Abortion, Eugenic; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D026689:Ethical Analysis; D004992:Ethics, Medical; D005260:Female; D030342:Genetic Diseases, Inborn; D005819:Genetic Markers; D006262:Health; D006801:Humans; D026684:Personal Autonomy; D011247:Pregnancy; D037841:Pregnant People; D011296:Prenatal Diagnosis; D013315:Stress, Psychological
chemical_list: D005819:Genetic Markers