title: Evaluation of a subunit vaccine for bovine adenovirus type 3.
abstract: The hexon subunit of bovine adenovirus serotype 3 (BAV-3) was purified by use of anion-exchange chromatography. A vaccine composed of the purified hexon in immune-stimulating complexes was administered and induced high titer of virus-neutralizing antibody in rabbits and calves.
authors.affiliation: Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph, Canada.
authors.forename: I A
authors.initials: IA
authors.lastname: York
authors.forename: J
authors.initials: J
authors.lastname: Thorsen
mesh_terms: D000256:Adenoviridae / Q000276:immunology* / Q000648:ultrastructure; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002213:Capsid / Q000276:immunology / Q000302:isolation & purification / Q000648:ultrastructure; D036022:Capsid Proteins; D002417:Cattle; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D016882:ISCOMs / Q000276:immunology; D015151:Immunoblotting; D008854:Microscopy, Electron; D011817:Rabbits; D014611:Vaccination / Q000662:veterinary; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins; D016882:ISCOMs; D014614:Vaccines, Synthetic; D014765:Viral Vaccines; C018315:hexon capsid protein, Adenovirus