CSF cholecystokinin concentrations in patients with panic disorder and in normal comparison subjects.
Cholecystokinin concentrations in the CSF of 25 patients with panic disorder and 16 normal comparison subjects were ascertained by radioimmunoassay. The patients with panic disorder had significantly lower CSF concentrations of cholecystokinin, which may reflect increased CNS cholecystokinin receptor sensitivity, reduced numbers of receptors, or a compensatory reduction in cholecystokinin octapeptide secondary to theoretically increased central cholecystokinin tetrapeptide activity.
Lydiard
R B
RB
Institute of Psychiatry, Medical University of South Carolina, Charleston 29425.
Ballenger
J C
JC
Laraia
M T
MT
Fossey
M D
MD
Beinfeld
M C
MC
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism; D002766:Cholecystokinin / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008875:Middle Aged; D016584:Panic Disorder / Q000134:cerebrospinal fluid* / Q000378:metabolism / Q000503:physiopathology; D011949:Receptors, Cholecystokinin / Q000378:metabolism / Q000502:physiology; D012844:Sincalide / Q000378:metabolism; D013758:Tetragastrin / Q000378:metabolism
D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; D002766:Cholecystokinin; D012844:Sincalide