Synthesis and O-demethylation rate of cis-[Pt(NH3)2(O6,9-dimethylguanine-7)2]Cl2: a study of the demethylation mechanism of O6-methylguanine-DNA methyltransferase.
Kohda
K
K
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Terashima
I
I
Sawada
N
N
Nozaki
I
I
Yasuda
M
M
Kawazoe
Y
Y
D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000737:chemistry; D003640:Dealkylation; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008780:Methyltransferases / Q000378:metabolism*; D019853:O(6)-Methylguanine-DNA Methyltransferase; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000378:metabolism*
D009944:Organoplatinum Compounds; C074484:cis-diamminebis(O(6),9-dimethylguanine-7)platinum(II); D006147:Guanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase; D002945:Cisplatin