title: [Preparation of stable W/O/W type multiple emulsion containing water-soluble drugs and in vitro evaluation of its drug-releasing properties].
abstract: The stable water-in-oil-in-water (W/O/W) multiple emulsion was prepared by a two-step procedure for emulsification using glyceryl tricaprylate (Panasate-800) as the oil phase. The water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine were selected and entrapped separately in the inner aqueous phase of W/O/W multiple emulsion. In consideration of parenteral administration, pH 7.4 phosphate buffered saline was used in both inner and outer aqueous phases. Moreover, these multiple emulsions could be significantly stable for a month at room temperature by the addition of hydrophilic polymer like gelatin and of amino acid like lysine to the inner aqueous phase.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Miyakawa
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: S
authors.initials: S
authors.lastname: Goto
mesh_terms: D000675:Ampyrone / Q000008:administration & dosage*; D000983:Antipyrine / Q000008:administration & dosage*; D002434:Cefadroxil / Q000008:administration & dosage*; D002515:Cephradine / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D012995:Solubility; D013696:Temperature; D014867:Water
chemical_list: D004655:Emulsions; D014867:Water; D000675:Ampyrone; D002434:Cefadroxil; D002515:Cephradine; D000983:Antipyrine