title: Tissue procoagulant activity may be important in sustaining metastatic tumour growth.
abstract: There is strong evidence for an association between the haemostatic system and malignancy. Thus, cancer may adversely affect the host coagulation system while the haemostatic system may play a role in the development of both primary and metastatic tumours. Metastatic growth is not dependent simply on haemodynamic factors, and properties of both the tumour cell and host organ are important determinants of the site of metastatic growth. Previous studies have demonstrated that some organs are preferred sites for metastasis while others are less preferred or resistant. We have measured the procoagulant activity (PCA) of normal rat and human tissues and correlated the results with the previously reported ability of these organs to support metastatic tumour growth. In addition, we determined changes in PCA in rat tissues during oral anticoagulant therapy, and following colonic anastomosis and partial hepatectomy, procedures which are known to affect experimental metastasis. In both rat and human studies, organs which are preferred sites for metastasis had significantly higher PCA than non-preferred organs (P less than 0.001). The PCA of adrenal, lung and colon was significantly reduced by administration of warfarin (P less than 0.001). PCA was significantly (P less than 0.001) increased in both colonic anastomoses and regenerating liver and followed a time course similar to that of the enhanced tumour growth usually seen in these situations. Although the exact source of the procoagulant activity remains to be determined, the results suggest that there is a broad correlation between tissue PCA and the ability of a tissue to support metastatic tumour growth.
authors.affiliation: University Surgical Unit, Southampton General Hospital, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Carty
authors.forename: I
authors.initials: I
authors.lastname: Taylor
authors.forename: O S
authors.initials: OS
authors.lastname: Roath
authors.forename: K
authors.initials: K
authors.lastname: el-Baruni
authors.forename: J L
authors.initials: JL
authors.lastname: Francis
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001779:Blood Coagulation Factors / Q000502:physiology*; D003106:Colon / Q000601:surgery; D006801:Humans; D008115:Liver Regeneration; D009362:Neoplasm Metastasis; D051381:Rats; D014859:Warfarin / Q000494:pharmacology
chemical_list: D001779:Blood Coagulation Factors; D014859:Warfarin