title: Yeast in blood cultures. Evaluation of factors influencing outcome.
abstract: Sixty episodes of candidemia occurring between January 1987 and September 1989 were retrospectively reviewed and the outcome was compared for three patient categories: neutropenic, postsurgical, and nonneutropenic nonsurgical. Because of increasing reports of resistant yeasts, minimal inhibitory concentrations (MICs) to amphotericin B (amB) were determined to examine its relationship to patient outcome. No significant differences between patient categories were found for selected risk factors, mortality, or species isolated, although there was a tendency for Candida tropicalis to occur in neutropenic patients. Statistical analysis using logistic regression showed that both an amB dose greater than 500 mg and a yeast MIC greater than 0.78 micrograms/ml were independent prognosticators of patient outcome.
authors.affiliation: Division of Medical Microbiology, Vancouver General Hospital, British Columbia, Canada.
authors.forename: E A
authors.initials: EA
authors.lastname: Bryce
authors.forename: F J
authors.initials: FJ
authors.lastname: Roberts
authors.forename: A S
authors.initials: AS
authors.lastname: Sekhon
authors.forename: A J
authors.initials: AJ
authors.lastname: Coldman
mesh_terms: D000328:Adult; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000209:etiology / Q000382:microbiology* / Q000401:mortality; D005260:Female; D016469:Fungemia / Q000209:etiology / Q000382:microbiology* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications; D011183:Postoperative Complications / Q000382:microbiology; D012189:Retrospective Studies; D016896:Treatment Outcome