[Nasolabial allergic reaction to intranasal administration of apomorphine in Parkinson disease].
A patient is presented who used apomorphine, a potent dopamine agonist in the treatment of Parkinson patients. He suffered of severe dystonia of the legs, which did not respond to conservative treatment. The apomorphine was delivered bij intranasal spray. The patient developed an allergic reaction with swollen nose and lips, which disappeared within one day after discontinuation of the treatment. Subcutaneous administration caused no symptoms. Cutaneous challenge with apomorphine caused a positive reaction. We raise the hypothesis that the allergic reaction was due to the binding of apomorphine to certain proteins in cutis or nasal mucosa.
van Laar
T
T
Afd. Neurologie, Medisch Spectrum Twente, Enschede.
Kruyswijk
M R
MR
Jansen
E N
EN
D000281:Administration, Intranasal; D000799:Angioedema / Q000139:chemically induced*; D001058:Apomorphine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007279:Injections, Subcutaneous; D008046:Lip; D008297:Male; D008875:Middle Aged; D009666:Nose; D010300:Parkinson Disease / Q000188:drug therapy*
D001058:Apomorphine
Nasolabiale allergische reactie op intranasale toediening van apomorfine bij de ziekte van Parkinson.