title: Successful treatment of angioimmunoblastic lymphadenopathy with dysproteinemia with cyclosporin A.
abstract: Angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) is a lymphoma-like disease. Although the histologic appearance of this disease is benign, it is clinically malignant, with chemotherapy being ineffective and the prognosis being poor. In this article, the authors report the results of treating two patients with AILD with cyclosporin A. One patient had cervical lymphadenopathy and fever, and AILD was refractory to both chemotherapy and alpha-interferon. However, treatment with cyclosporin A achieved complete remission. The other patient had generalized lymphadenopathy, and cyclosporin A was used as the treatment of first choice. Complete remission also was achieved in this patient, who still is in remission. These two cases demonstrate that cyclosporin A can be effective for treating AILD.
authors.affiliation: Department of Internal Medicine, Hyogo Medical Center for Adults, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Murayama
authors.forename: S
authors.initials: S
authors.lastname: Imoto
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Matozaki
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
mesh_terms: D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000188:drug therapy; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D012074:Remission Induction
chemical_list: D016572:Cyclosporine