title: MRI susceptometry: image-based measurement of absolute susceptibility of MR contrast agents and human blood.
abstract: We present a novel NMR imaging technique that allows absolute determination of the magnetic susceptibility constant, chi, of a solution. By comparing the phase difference of MR images produced with an instant (echo planar) "offset" spin-echo sequence, we obtain a direct measure of the magnetic field perturbations caused by the solution. We demonstrate this method with Gd(DTPA), Dy(DTPA), human red blood cells, and superparamagnetic iron oxide particles.
authors.affiliation: Massachusetts General Hospital, Department of Radiology, Charlestown 02129.
authors.forename: R M
authors.initials: RM
authors.lastname: Weisskoff
authors.forename: S
authors.initials: S
authors.lastname: Kiihne
mesh_terms: D003287:Contrast Media; D003911:Dextrans; D004419:Dysprosium; D004912:Erythrocytes; D052203:Ferrosoferric Oxide; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D066298:In Vitro Techniques; D007501:Iron; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; D004369:Pentetic Acid / Q000031:analogs & derivatives
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D010087:Oxides; D004419:Dysprosium; D004369:Pentetic Acid; C055865:dysprosium DTPA; D005682:Gadolinium; D007501:Iron; C065507:ferumoxides; D019786:Gadolinium DTPA; D052203:Ferrosoferric Oxide