title: Effects of isolation on interferon production and hematological and immunological parameters.
abstract: A 27-year-old woman was maintained in an isolated state for 131 days in Carlsbad Caverns, New Mexico. Her diet was vitamin D-depleted. Determinations on the effects of such isolation on levels and activities of peripheral blood cells that are important for hematological homeostasis and immunological function were carried out. Throughout the duration of the study, the percentage of lymphoid cells that expressed CD3, CD4, CD8, CD19, Leu 8, and other markers remained relatively constant although the absolute numbers of these cells varied. Although the percentage of natural killer (NK) cells did not vary, the activity of these cells did change. NK cell activity became elevated as the isolation study progressed. Production of interferon-gamma (IFN-gamma) in response to mitogen stimulation was higher than expected throughout the isolation periods, but returned to the normal range after termination of the isolation. Red and white cell counts dropped significantly upon entering isolation, but soon returned to normal.
authors.affiliation: Department of Microbiology and Immunology, School of Medicine, University of Louisville, KY 40292.
authors.forename: G
authors.initials: G
authors.lastname: Sonnenfeld
authors.forename: J
authors.initials: J
authors.lastname: Measel
authors.forename: M R
authors.initials: MR
authors.lastname: Loken
authors.forename: J
authors.initials: J
authors.lastname: Degioanni
authors.forename: S
authors.initials: S
authors.lastname: Follini
authors.forename: A
authors.initials: A
authors.lastname: Galvagno
authors.forename: M
authors.initials: M
authors.lastname: Montalbini
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology*; D010976:Platelet Count; D012934:Social Isolation
chemical_list: D007371:Interferon-gamma