Pediatric heart transplantation for doxorubicin-induced cardiomyopathy.
The prognosis of patients with a history of successfully treated malignancy, who subsequently undergo organ transplantation and long-term immunosuppression, is uncertain. We report the case of a 14-year-old girl in whom doxorubicin-induced cardiomyopathy developed after aggressive therapy for a fibroblastic osteosarcoma. The patient underwent orthotopic heart transplantation and remains in remission 14 months after surgery.
McManus
R P
RP
Department of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee 53226.
O'Hair
D P
DP
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000601:surgery; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005266:Femoral Neoplasms / Q000188:drug therapy; D016027:Heart Transplantation; D006801:Humans; D012516:Osteosarcoma / Q000188:drug therapy
D004317:Doxorubicin