title: Primary B-cell lymphoma with histologic features of a T-cell neoplasm.
abstract: A 58-year-old white man had dermatomyositis and primary cutaneous B-cell lymphoma. The cutaneous lymphoma was evidenced by a noduloulcerative disease of the lower extremities. Histologic results resembled a T-cell process with a diffuse, superficial infiltrate composed of small- and medium-sized lymphocytes with angioinvasion and epidermotropism. The infiltrate extended into the deep dermis and panniculus with scattered large lymphocytes and necrosis. With the help of gene-rearrangement analysis and immunophenotyping, the true B-cell lineage was discovered. The importance of gene-rearrangement analysis and immunophenotyping in the diagnosis of cutaneous lymphoma is emphasized.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
authors.forename: N G
authors.initials: NG
authors.lastname: Landa
authors.forename: B D
authors.initials: BD
authors.lastname: Zelickson
authors.forename: P J
authors.initials: PJ
authors.lastname: Kurtin
authors.forename: R K
authors.initials: RK
authors.lastname: Winkelmann
mesh_terms: D015139:Blotting, Southern; D003882:Dermatomyositis / Q000150:complications; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D007866:Leg / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*