Positive Kveim test in patients with coexisting sarcoidosis and human immunodeficiency virus infection.
We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were active in the patient with asymptomatic HIV infection. Both patients had granulomatous reactions to Kveim antigen, and one had such a reaction following an AIDS-defining infection. These findings suggest that non-T-cell mechanisms may be involved in granuloma formation in sarcoidosis.
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Division of Pulmonary and Critical Care Medicine, Mount Sinai Medical Center, New York.
Sperber
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Brown
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Chusid
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Teirstein
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D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007731:Kveim Test; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology