title: Aerobilia and hypomotility of the sphincter of Oddi in a patient with chronic intestinal pseudo-obstruction.
abstract: A 50-year-old woman with a typical history of chronic idiopathic intestinal pseudo-obstruction was admitted to hospital because of an acute episode of abdominal cramps, nausea, and vomiting. The diagnosis of chronic idiopathic intestinal pseudo-obstruction had been established in this patient who had malnutrition and extreme weight loss as a result of severe malabsorption syndrome. The abdominal roentgenogram showed a typical hypotonic intestine with an enlarged stomach and distended intestinal loops with the radiological signs of an ileus. In addition to former episodes, there was also a transient aerobilia. The patient had not undergone biliary surgery or endoscopic sphincterotomy. To investigate the cause of the findings, endoscopic retrograde cholangiopancreatography and endoscopic manometry of the sphincter of Oddi were performed. The endoscopy showed the stomach and duodenum with a wide and dilated lumen and no spontaneous motility. Endoscopic manometry of the biliary tract and the sphincter of Oddi showed several abnormalities compared with a group of normal volunteers or patients who were examined via biliary manometry for other reasons. There was a low basal pressure (3.5 mm Hg) in the sphincter of Oddi together with low-amplitude phasic contractions (25-30 mm Hg), but the contraction frequency was in the normal range. Further investigations of the motility of the gastrointestinal tract in this patient showed diffuse esophageal spasms and a markedly delayed gastric emptying. The findings of biliary manometry in this patient suggest involvement of the sphincter of Oddi and the biliary system in chronic idiopathic pseudo-obstruction.
authors.affiliation: II Medizinische Klinik und Poliklinik, Technischen Universität München, Germany.
authors.forename: H D
authors.initials: HD
authors.lastname: Allescher
authors.forename: L
authors.initials: L
authors.lastname: Safrany
authors.forename: H
authors.initials: H
authors.lastname: Neuhaus
authors.forename: H
authors.initials: H
authors.lastname: Feussner
authors.forename: M
authors.initials: M
authors.lastname: Classen
mesh_terms: D000388:Air; D001659:Biliary Tract / Q000503:physiopathology*; D002908:Chronic Disease; D004947:Esophagus / Q000000981:diagnostic imaging; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology / Q000503:physiopathology*; D008365:Manometry; D008875:Middle Aged; D011859:Radiography; D009803:Sphincter of Oddi / Q000503:physiopathology*