Automated clean-up procedure for the gas chromatographic-high-resolution mass spectrometric determination of polychlorinated dibenzo-p-dioxins and dibenzofurans in milk.
A highly automated extraction and clean-up method for polychlorinated dibenzodioxins and polychlorinated dibenzofurans is described. The method includes the use of gel permeation chromatography, alumina clean-up and porous graphitized carbon chromatography, followed by analysis by gas chromatography-high-resolution mass spectrometry. The procedure allows for the analysis of six milk samples per day in addition to two quality control samples and a blank. Detection limits on a fat basis for the individual congeners in milk samples are in the sub-ppt range. Long-term performance was investigated and data are given for reproducibility, precision and accuracy.
van Rhijn
J A
JA
State Institute for Quality Control of Agricultural Products, Wageningen, Netherlands.
Traag
W A
WA
Kulik
W
W
Tuinstra
L G
LG
D000818:Animals; D001572:Benzofurans / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D008892:Milk / Q000032:analysis*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis; D011108:Polymers / Q000032:analysis*; D011786:Quality Control; D015203:Reproducibility of Results
D001572:Benzofurans; D000072317:Polychlorinated Dibenzodioxins; D011108:Polymers; C016068:polychlorodibenzofuran