Cardiotoxic effects of astemizole overdose in children.
Astemizole, a nonsedating antihistamine, caused a prolonged corrected QT interval, ventricular dysrhythmias, and atrioventricular heart block after overdose in five children. Cardiotoxic effects lasted an average of 2 1/2 days. Children poisoned with astemizole need emergent medical evaluation, a 12-lead electrocardiogram with calculation of the corrected QT interval, and continuous cardiac monitoring for 24 hours.
Wiley
J F
JF
Section of General Pediatrics, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania.
Gelber
M L
ML
Henretig
F M
FM
Wiley
C C
CC
Sandhu
S
S
Loiselle
J
J
D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000175:diagnosis; D016589:Astemizole / Q000506:poisoning*; D002648:Child; D002675:Child, Preschool; D004562:Electrocardiography; D006327:Heart Block / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male
D016589:Astemizole