title: High-dose etoposide in treatment of metastatic breast cancer.
abstract: High-dose etoposide (1,500-2,500 mg/m2) was used for the treatment of 23 previously treated patients with advanced breast cancer. Six of 23 (26%) showed objective regression with a median duration of response of 5 months. Responses were seen at all sites apart from bone. Response was related to dose level with 11/23 responses of measurable lesions occurring at doses greater than or equal to 2,000 mg/m2 as compared to 2/23 responses at a dose of 1,500 mg/m2. The treatment regimen was able to be given on an outpatient basis with only routine supportive measures. High-dose etoposide may come to play a role in high-dose combination chemotherapy regimens for advanced breast cancer.
authors.affiliation: Department of Medicine, University of the Witwatersrand Medical School, Johannesburg Hospital, South Africa.
authors.forename: W R
authors.initials: WR
authors.lastname: Bezwoda
authors.forename: L
authors.initials: L
authors.lastname: Seymour
authors.forename: S
authors.initials: S
authors.lastname: Ariad
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005047:Etoposide / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis
chemical_list: D005047:Etoposide