Cytostatics and anastomotic healing in the intestine: an experimental study on the effect of parenteral nutrition.
The effects of parenteral nutrition on the healing of experimental ileal and colonic anastomoses constructed on the 3rd day of a 5-day cytostatics course were investigated. Intravenous saline alone already reduced weight loss induced by cytostatics while parenteral nutrition almost completely prevented postoperative loss of weight. A negative effect of cytostatics on anastomotic bursting strength was found in the ileum 7 days after operation. Parenteral feeding negated this effect but had no positive effect on anastomotic hydroxyproline content. Thus, parenteral nutrition increases the strength of intestinal anastomoses, constructed during a cytostatics regimen, but intravenous saline alone also appears to have a similar effect.
de Roy van Zuidewijn
D B
DB
Department of General Surgery, St. Radboud University Hospital, Nijmegen, The Netherlands.
Hendriks
T
T
Wobbes
T
T
de Man
B
B
de Boer
H H
HH
D000714:Anastomosis, Surgical; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001835:Body Weight / Q000187:drug effects; D003106:Colon / Q000378:metabolism / Q000601:surgery*; D006909:Hydroxyproline / Q000032:analysis; D007082:Ileum / Q000378:metabolism / Q000601:surgery*; D008297:Male; D010288:Parenteral Nutrition; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects
D006909:Hydroxyproline