Drug-induced pemphigus related to angiotensin-converting enzyme inhibitors.
We report a case of drug-induced pemphigus caused by an angiotensin-converting enzyme inhibitor, captopril. The cutaneous reaction remitted after withdrawal of captopril therapy. Unique to this case, however, was the substitution of another angiotensin-converting enzyme inhibitor, enalapril, without exacerbation of the pemphigus. To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril. A difference in chemical structure between these two drugs, particularly of a sulfur moiety, may help explain why the drug-induced disease did not recur.
Kaplan
R P
RP
Division of Dermatology, UCLA School of Medicine 90024.
Potter
T S
TS
Fox
J N
JN
D000368:Aged; D000369:Aged, 80 and over; D002216:Captopril / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D010392:Pemphigus / Q000139:chemically induced*; D013997:Time Factors
D002216:Captopril