title: Expression of alpha-melanocyte stimulating hormone and the invasive ability of the B16 murine melanoma.
abstract: The expression of alpha melanocyte stimulating hormone (MSH) has been investigated in two variants of the B16 murine melanoma. The presence of MSH was demonstrated by immunohistochemical methods using anti-MSH antibodies. The low metastasis variant B16-F1, which grows as an encapsulated non-invasive tumour, showed no alpha-MSH immunoreactivity. In contrast, the high metastasis variant BL6 was found to be alpha-MSH positive and the immunoreactivity was found predominantly in the peripheral invading zones of the tumour.
authors.affiliation: Cancer Research Unit, Medical School, University of Newcastle upon Tyne, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Zubair
authors.forename: M S
authors.initials: MS
authors.lastname: Lakshmi
authors.forename: G V
authors.initials: GV
authors.lastname: Sherbet
mesh_terms: D000818:Animals; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis*; D008546:Melanoma, Experimental / Q000737:chemistry / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness
chemical_list: D009074:Melanocyte-Stimulating Hormones