title: Nucleotide sequence comparison of the M1 genome segment of reovirus type 1 Lang and type 3 Dearing.
abstract: The mammalian reoviruses possess a genome composed of 10 double stranded RNA segments. The serotype 1 strain Lang M1 segment was sequenced and compared to the published type 3 sequence. Both segments were 2304 base-pairs long coding for the mu 2 protein predicted to be 736 amino acids long. The sequences were highly conserved with 97.2% conservation of nucleotide sequence and 98.6% conservation of amino acid sequence. The M1 segments of serotypes 1 and 3 have recently diverged as indicated by the distribution of variation with respect to codon positions. The conservation of amino acid sequence indicated that the mu 2 protein has a relatively high functional density.
authors.affiliation: Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ont., Canada.
authors.forename: S
authors.initials: S
authors.lastname: Zou
authors.forename: E G
authors.initials: EG
authors.lastname: Brown
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D016679:Genome, Viral; D012089:Mammalian orthoreovirus 3 / Q000235:genetics*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger / Q000737:chemistry; D012367:RNA, Viral / Q000737:chemistry / Q000302:isolation & purification; D012087:Reoviridae / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification
chemical_list: D012333:RNA, Messenger; D012367:RNA, Viral; D014764:Viral Proteins