title: Resolution of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine and selective inhibition of human immunodeficiency virus by the (-) enantiomer.
abstract: Two enantiomers of 9-(c-4,t-5-bishydroxymethylcyclopent-2-en-r-1-yl)-9H- adenine (BCA) which showed a potent and selective anti-HIV effects have been synthesized and evaluated against human immunodeficiency virus type 1. The result demonstrated that the potent-HIV activity of racemic BCA is expressed solely by the (-) isomer.
authors.affiliation: Pharmaceutical Institute, Tohoku University, Sendai, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Katagiri
authors.forename: T
authors.initials: T
authors.lastname: Shiraishi
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Toyota
authors.forename: C
authors.initials: C
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Yusa
authors.forename: T
authors.initials: T
authors.lastname: Oh-hara
authors.forename: T
authors.initials: T
authors.lastname: Tsuruo
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003517:Cyclopentanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D013237:Stereoisomerism
chemical_list: D000998:Antiviral Agents; D003517:Cyclopentanes; C074108:9-(4,5-bishydroxymethylcyclopent-2-en-1-yl)-9H-adenine; D000225:Adenine