Botulinum toxin as a treatment for blepharospasm, spasmodic torticollis and hemifacial spasm.
Fifty-two patients affected by focal dystonia or hemifacial spasm were treated with repeated injections of botulinum toxin. A clinical improvement was observed in all patients with blepharospasm; clinical benefit had a mean duration of 10 weeks. Clinical results were less impressive, but also favorable in patients affected by spasmodic torticollis and by hemifacial spasm. In the latter, the incidence of drug-induced paresis was much higher than that observed in patients with blepharospasm, even though the doses of toxin injected were significantly lower.
Albanese
A
A
Istituto di Neurologia, Università Cattolica del Sacro Cuore, Roma, Italy.
Colosimo
C
C
Carretta
D
D
Dickmann
A
A
Bentivoglio
A R
AR
Tonali
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001764:Blepharospasm / Q000188:drug therapy* / Q000209:etiology; D001905:Botulinum Toxins / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005152:Facial Muscles / Q000187:drug effects; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D013035:Spasm / Q000188:drug therapy*; D014103:Torticollis / Q000188:drug therapy* / Q000209:etiology
D001905:Botulinum Toxins