Osteoporosis syndromes: patient selection for calcitonin therapy.
Synthetic calcitonin-salmon is a treatment option for older patients with postmenopausal osteoporotic syndromes. Some clinical trials reveal a simple suppression of annual bone-loss rates with calcitonin therapy, whereas others show significant dose-related increases in vertebral and long-bone mass. Response is greater in patients with high-turnover (type I) osteoporosis than in those with the low/normal (type II) form. Candidates for calcitonin-salmon therapy include older women with established vertebral fractures, those who are osteopenic by bone mass analysis, and those in need of preventive therapy because of an accumulation of risk factors.
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Division of Bone and Mineral Diseases, School of Medicine, Washington University, St. Louis.
D000368:Aged; D002116:Calcitonin / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000145:classification / Q000150:complications / Q000188:drug therapy*; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control; D013577:Syndrome
C028815:salmon calcitonin; D002116:Calcitonin