Incidence of cystic fibrosis in Saguenay-Lac-St.-Jean (Quebec, Canada).
The incidence of cystic fibrosis (CF) in Saguenay-Lac-St.-Jean, a geographically isolated region of Quebec, was estimated to be 1 in 902 during the period 1975-1988. The carrier rate was calculated to be 1 in 15 inhabitants. The high incidence of CF in Saguenay-Lac-St.-Jean is probably the result of a founder effect and genetic drift for one or more mutations. Historical, demographic, and social factors also may have contributed to the high incidence.
Daigneault
J
J
Department of Human Sciences, Universite du Quebec a Chicoutimi, Canada.
Aubin
G
G
Simard
F
F
De Braekeleer
M
M
D002353:Carrier State / Q000453:epidemiology; D002410:Catholicism; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D004641:Emigration and Immigration; D005602:France / Q000208:ethnology; D005787:Gene Frequency; D005788:Gene Pool; D006801:Humans; D015994:Incidence; D011792:Quebec / Q000453:epidemiology; D044465:White People