title: The lysine analog L-oxalysine is an inhibitor of RNA synthesis.
abstract: 1. The lysine analog L-4-oxalysine was found to be a potent inhibitor of RNA synthesis in Candida albicans. 2. The compound was a weak inhibitor of protein synthesis and DNA synthesis was not affected. 3. The inhibition of RNA synthesis was reversed by L-lysine but not D-lysine. 4. The decrease in the level of newly synthesized RNA in cells treated with L-oxalysine was due to inhibition of de novo synthesis rather than to degradation of RNA.
authors.affiliation: Department of Microbiology, University of Tennessee, Knoxville 37901.
authors.forename: H
authors.initials: H
authors.lastname: Zheng
authors.forename: H L
authors.initials: HL
authors.lastname: Zhang
authors.forename: J M
authors.initials: JM
authors.lastname: Becker
authors.forename: F
authors.initials: F
authors.lastname: Naider
authors.forename: W R
authors.initials: WR
authors.lastname: Farkas
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D004271:DNA, Fungal / Q000096:biosynthesis; D004587:Electrophoresis, Agar Gel; D005656:Fungal Proteins / Q000096:biosynthesis; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives*; D012331:RNA, Fungal / Q000096:biosynthesis*
chemical_list: D000596:Amino Acids; D000600:Amino Acids, Dicarboxylic; D004271:DNA, Fungal; D005656:Fungal Proteins; D012331:RNA, Fungal; C027136:4-oxalysine; D008239:Lysine