Chemical and in vivo studies of interaction between cadmium and vitamin B6.
The interaction of vitamin B6 pyridoxine with cadmium acetate in ethanolic solution has been studied. The new compound Cd(PN-H)(OOCCH3) (PN-H = pyridoxinato anion) was isolated and its structure studied in the solid state by IR and 13C and 113Cd CP/MAS NMR spectroscopies. The effect of pyridoxine on survival rate among male Sprague rats injected intraperitoneally with 5 mg CdCl2.H2O/kg was also investigated. Vitamin treatment seems to increase (Protocol C) or does not affect the cadmium lethality. Although the analysis of the metal burden in some organs seems to suggest a light increase of the cadmium level in the liver, this change has no significance at a statistical level.
Couce
M D
MD
Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Galicia, Spain.
Varela
J M
JM
Sánchez
A
A
Casas
J S
JS
Sordo
J
J
López-Rivadulla
M
M
D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D019256:Cadmium Chloride; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011736:Pyridoxine / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013055:Spectrophotometry, Infrared
D002712:Chlorides; D002104:Cadmium; D019256:Cadmium Chloride; D011736:Pyridoxine