title: Quantitation of immunoglobulin-containing cells in the jejunal lamina propria in tropical sprue.
abstract: Ten patients with tropical sprue (TS) and 10 with irritable bowel syndrome (IBS) as controls were studied to characterize the immunocytes in the jejunal mucosa. IgA cells numbered 516,155 +/- 48,715 cells/mm3 in TS and 729,308 +/- 146,011/mm3 in the IBS patients. IgG cell counts were 28,885 +/- 8,081/mm3 in TS and 10,615 +/- 4,100/mm3 in IBS; IgM counts were 170,729 +/- 25,015/mm3 in TS and 169,253 +/- 45,353/mm3 in IBS. A positive correlation was present between IgM-bearing plasma cells and corresponding serum immunoglobulins (r = +0.71; p less than 0.05). No correlation was evident between the different immunocytes (IgA, IgG, and IgM) and the duration of illness, serum albumin, and tests for absorption of fat, B-12, and D-xylose (p greater than 0.05). The gut immunocytes expressed in absolute numbers were higher in our controls and TS patients than reported in Western populations.
authors.affiliation: Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Malik
authors.forename: S K
authors.initials: SK
authors.lastname: Mehta
authors.forename: Y
authors.initials: Y
authors.lastname: Chandrashekhar
authors.forename: A
authors.initials: A
authors.lastname: Mahajan
authors.forename: V
authors.initials: V
authors.lastname: Nanda
authors.forename: R
authors.initials: R
authors.lastname: Kochhar
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000473:pathology*; D002452:Cell Count; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis*; D007413:Intestinal Mucosa / Q000737:chemistry / Q000473:pathology*; D007583:Jejunum / Q000737:chemistry / Q000473:pathology*; D008297:Male
chemical_list: D007136:Immunoglobulins