Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC.
The length of time after which persons infected with HIV-1 progress to AIDS is variable. Certain alleles at the MHC have been shown to influence negatively the clinical outcome of HIV-1-infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV-1-infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleles.
Hentges
F
F
Department of Immuno-Allergology, Centre Hospitalier de Luxembourg.
Hoffmann
A
A
Oliveira de Araujo
F
F
Hemmer
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology; D000328:Adult; D000483:Alleles; D003181:Complement C4 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D015497:HIV-1; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D008285:Major Histocompatibility Complex; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D003181:Complement C4; D006680:HLA Antigens