Oral intraepidermal IgA pustulosis and Crohn's disease.
A case is reported of a 60-year-old woman with Crohn's disease who developed recurrent oral blisters and erosions. The histopathology of the buccal mucosa showed intraepidermal bullae and clefts with an intense accumulation of neutrophils in the epithelium. Direct immunofluorescence revealed intercellular IgA predominantly in the basal and suprabasal layers and in one biopsy concurrent deposits of IgG. No circulating autoantibodies were detected.
Borradori
L
L
Department of Dermatology, Hôpital Saint Louis, University of Paris VII, France.
Saada
V
V
Rybojad
M
M
Flageul
B
B
Kuffer
R
R
Lémann
M
M
Verola
O
O
Modigliani
R
R
Morel
P
P
D003424:Crohn Disease / Q000150:complications* / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000276:immunology; D009061:Mouth Mucosa / Q000276:immunology*; D012871:Skin Diseases / Q000209:etiology* / Q000276:immunology
D007070:Immunoglobulin A