title: In vitro and in vivo evaluation of a hydrophilized silicone intraocular lens.
abstract: The surface of a silicone-disc intraocular lens (IOL) was hydrophilized by plasma etching (oxygen plasma) and compared to an untreated but otherwise identical IOL. Various methods of surface analysis were used to characterize the modification (e.g., X-ray photoelectron spectroscopy, contact angle estimation). A cytotoxic effect of the modified surface was excluded by cell culture experiments evaluating cell spreading, cell morphology, DNA and protein synthesis. In vivo experiments on rabbits indicated that the postoperative foreign-body reaction was not significantly affected by the hydrophilization of the IOL surface. Throughout the entire follow-up (12 weeks) we found less induced posterior synechias in the eyes with hydrophilized lenses than in those with untreated lenses (P = .009). While the IOL dislocations out of the capsular bag and the posterior capsular opacification rate did not differ significantly between the two groups of eyes, we did see special patterns of posterior capsular opacification on the posterior capsules of eyes with the hydrophilized IOL.
authors.affiliation: Institute of Pathology of the RWTH Aachen, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Hettlich
authors.forename: R
authors.initials: R
authors.lastname: Kaufmann
authors.forename: H
authors.initials: H
authors.lastname: Harmeyer
authors.forename: E
authors.initials: E
authors.lastname: Imkamp
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirkpatrick
authors.forename: C
authors.initials: C
authors.lastname: Mittermayer
mesh_terms: D000818:Animals; D002386:Cataract / Q000209:etiology* / Q000473:pathology; D002455:Cell Division; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology; D015726:Giant Cells / Q000648:ultrastructure; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008264:Macrophages / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D012826:Silicone Elastomers / Q000494:pharmacology; D013499:Surface Properties; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D012826:Silicone Elastomers