The exact values of the probability of fixation of underdominant chromosomal rearrangements.
A numerical analysis of the probability of fixation of a chromosomal mutation with partial sterility of the heterozygote in a single population is performed. Three different genetic models are considered: the first model entails constant selection against the heterozygote and is the model almost universally used in previous works; in the other two models selection against the heterozygote depends on its frequency. The exact values of the fixation probability are found by iterating transition matrices with genotype specification. Differences in results among models are small. The exact values found in the first model are compared to estimates obtained from approximations. Solutions based on diffusion models give good approximations when selection against the heterozygote is low, especially if the population is very small. For the higher values of the selection coefficient against the heterozygote, the estimates are rather imprecise, especially when the populations are not very small.
Spirito
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Department of Genetics and Molecular Biology, Faculty of M.F.N. Sciences, La Sapienza University, Rome, Italy.
D000818:Animals; D005799:Genes, Dominant / Q000235:genetics*; D006580:Genetic Carrier Screening; D005828:Genetics, Population; D006801:Humans; D007246:Infertility / Q000235:genetics*; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation / Q000235:genetics*; D012641:Selection, Genetic