title: DNA image cytometry: a prognostic tool in rectal cancer?
abstract: In 68 patients the DNA content of tumor cells was measured by image cytometry after resection of the rectum because of cancer. In the DNA histogram a differentiation between diploid (n = 19), polyploid (n = 24), hypotriploid (n = 17), and hypertriploid (n = 8) tumors was possible. The best relapse-free survival time was found in patients with diploid tumors. The prognosis worsened from polyploid to hypotriploid and was worse in hypertriploid tumors. Testing for a prognostic advantage of diploid over aneuploid tumors without adjustment for additional factors simply by means of the log-rank statistic gave a (one-sided) P of 0.1013. In a multivariate analysis the degree of differentiation turned out most important. Again, an appropriate test for prognostic relevance of DNA content failed to be significant (P = 0.3264).
authors.affiliation: Department of General and Abdominal Surgery, Johannes Gutenberg-University Mainz, Germany.
authors.forename: T C
authors.initials: TC
authors.lastname: Böttger
authors.forename: H E
authors.initials: HE
authors.lastname: Gabbert
authors.forename: M
authors.initials: M
authors.lastname: Stöckle
authors.forename: S
authors.initials: S
authors.lastname: Wellek
authors.forename: R
authors.initials: R
authors.lastname: Hils
authors.forename: A
authors.initials: A
authors.lastname: Heintz
authors.forename: T
authors.initials: T
authors.lastname: Junginger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003198:Computer Simulation; D003592:Cytophotometry / Q000379:methods*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011003:Ploidies; D011379:Prognosis; D012004:Rectal Neoplasms / Q000235:genetics / Q000473:pathology*; D012307:Risk Factors
chemical_list: D004273:DNA, Neoplasm