title: An amino-proximal domain required for the localization of FtsQ in the cytoplasmic membrane, and for its biological function in Escherichia coli.
abstract: The location of FtsQ, an Escherichia coli protein essential for cell division, is, under physiological conditions, in the cytoplasmic membrane facing towards the periplasmic space. An amino-proximal hydrophobic domain is required for FtsQ to reach its location and for its activity in the cell. Overexpression of modified forms of FtsQ is deleterious for the cell.
authors.affiliation: Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Dopazo
authors.forename: P
authors.initials: P
authors.lastname: Palacios
authors.forename: M
authors.initials: M
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Pla
authors.forename: M
authors.initials: M
authors.lastname: Vicente
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D001692:Biological Transport; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism*; D003001:Cloning, Molecular; D003854:Deoxyribonucleotides; D004591:Electrophoresis, Polyacrylamide Gel; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D029968:Escherichia coli Proteins; D005816:Genetic Complementation Test; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009154:Mutation; D010957:Plasmids; D014357:Trypsin
chemical_list: D001426:Bacterial Proteins; D003854:Deoxyribonucleotides; D029968:Escherichia coli Proteins; C068023:FtsQ protein, E coli; D008565:Membrane Proteins; D014357:Trypsin