Effect of gamma-butyrolactone on baclofen inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
The effect of gamma-butyrolactone (GBL) on inhibition by baclofen of gastric carcinogenesis was investigated in Wistar rats. In week 52, baclofen significantly decreased the incidence of gastric cancers. Concomitant treatment with GBL significantly increased gastric acid secretion but had no influence on the inhibition by baclofen of gastric carcinogenesis. This finding suggest that GBL significantly increased the sensitivity of gamma-aminobutyric acid (GABA) receptor to GABA mimetics in gastric acid secretion but not in the inhibitory effect of gastric carcinogenesis.
Tatsuta
M
M
Department of Gastrointestinal Oncology, Center for Adult Diseases, Osaka, Japan.
Iishi
H
H
Baba
M
M
Nakaizumi
A
A
Uehara
H
H
Taniguchi
H
H
D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D005750:Gastric Juice / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006863:Hydrogen-Ion Concentration; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D011919:Rats, Inbred Strains; D012636:Secretory Rate / Q000187:drug effects; D013274:Stomach Neoplasms / Q000139:chemically induced*
D005755:Gastrins; D008769:Methylnitronitrosoguanidine; D004247:DNA; D001418:Baclofen; D015107:4-Butyrolactone