title: Mechanism of ovulation.
abstract: This article provides a fundamental basis for a better understanding of normal ovarian physiologic processes relevant to the pathophysiology of ovarian dysfunction and the treatment of infertility. The discussion centers on the pelvic clock, which regulates by steroidal and nonsteroidal endocrine and paracrine messages both hypothalamic-pituitary and intraovarian functions essential to successful reproduction, and the steroidal milieu that generates the approximately 28-day human menstrual cycle.
authors.affiliation: Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk.
authors.forename: F
authors.initials: F
authors.lastname: Irianni
authors.forename: G D
authors.initials: GD
authors.lastname: Hodgen
mesh_terms: D001920:Bradykinin / Q000502:physiology; D003338:Corpus Luteum / Q000502:physiology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology; D006062:Gonadotropins / Q000502:physiology; D006632:Histamine / Q000502:physiology; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology; D008597:Menstrual Cycle / Q000502:physiology; D009866:Oogenesis / Q000502:physiology; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000098:blood supply; D010060:Ovulation / Q000502:physiology*; D010062:Ovulation Induction / Q000379:methods; D011453:Prostaglandins / Q000502:physiology
chemical_list: D006062:Gonadotropins; D011453:Prostaglandins; D006632:Histamine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D001920:Bradykinin