title: [Stage-independence and individual outcome of neuro-cognitive deficits in HIV. A follow-up study of 62 HIV-positive hemophilic patients].
abstract: 62 of a series of 188 HIV-positive hemophiliacs, who had been neuropsychologically evaluated already in 1988 (T1), were re-examined 1 1/2 years later (T2). The aims of the study were to confirm the cross-sectional results of the 1988 study and to compare cross-sectional and longitudinal aspects of HIV infection and associated neurocognitive deficits. Patients were staged at T1 and T2 according to CDC classification criteria and retested using parallel tests of attention, verbal/nonverbal memory performance and depression. The following results were observed: (i) Data at T2 paralleled the findings from 1988, indicating increased deficits in attention and verbal learning and memory at an advanced stage of the disease. No association with the T4/T8 ratio was found. (ii) Between T1 and T2, 65% of the patients showed no change in stage, 27% changed one stage and only 8% showed a rapid progression through two stages. (iii) Only this latter group showed a significant cognitive deterioration over time. The remaining groups exhibited inconsistent performance changes which did not correlate with depression of changes of the T4/T8 ratio. Conclusively, the longitudinal data support the assumption of stage independent and individual different courses of the neurocognitive manifestations of HIV. A small minority of patients, however, manifested a rapid progression of the disease during the T1-T2 interval.
authors.affiliation: Universitätsklinik für Epileptologie, Bonn.
authors.forename: C
authors.initials: C
authors.lastname: Helmstaedter
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: C
authors.initials: C
authors.lastname: Niese
authors.forename: H H
authors.initials: HH
authors.lastname: Brackmann
authors.forename: R
authors.initials: R
authors.lastname: Sass
mesh_terms: D015526:AIDS Dementia Complex / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000150:complications* / Q000523:psychology; D006467:Hemophilia A / Q000150:complications* / Q000523:psychology; D006801:Humans; D007361:Intelligence Tests / Q000706:statistics & numerical data; D008137:Longitudinal Studies; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011594:Psychometrics
vernacular_title: Stadienunabhängig und individuell verlaufende neurokognitive Defizite bei HIV. Eine Follow-up-Studie an 62 HIV-positiven Hämophilen.