Pathologic features of SIV-induced disease and the association of macrophage infection with disease evolution.
Since the original isolation of simian immunodeficiency virus (SIV) from a macaque with an AIDS-like disease, numerous studies have demonstrated the close biologic and genetic relationship of the SIVs to the HIVs. Probably most important, the clinical spectrum of disease associated with SIVmac/SIVsmm infection in rhesus monkeys is strikingly similar to AIDS in HIV-1-infected human beings. Herein are summarized the pathologic features of SIVmac-induced disease in a cohort of rhesus monkeys, with special reference to the role of infected macrophages in the development of AIDS-related manifestations.
Simon
M A
MA
Department of Pathology, Harvard Medical School, New England Regional Primate Research Center, Southborough, MA.
Chalifoux
L V
LV
Ringler
D J
DJ
D000818:Animals; D004198:Disease Susceptibility / Q000382:microbiology*; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000209:etiology / Q000473:pathology; D008264:Macrophages / Q000382:microbiology; D009894:Opportunistic Infections / Q000473:pathology; D009928:Organ Specificity; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000473:pathology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D015302:Simian Immunodeficiency Virus