Placental alterations, intrauterine growth retardation and teratogenicity associated with enalapril use in pregnant rats.
Enalapril (15 mg/kg/day p.o.) was given to 11 pregnant rats from day 1 to 9 (E1-9) and to 11 rats from day 10 to 20 (E10-20) of pregnancy; 12 rats were the control group. Fifteen animals were sacrificed on day 20 of pregnancy and 19 were allowed to progress into partum. Placentas were smaller in E10-20 rats (-15%, p less than 0.05) and had a simple hypocellular cordonal structure; in E1-9 animals the predominant pattern was a combination of complex and simple structure. At day 20 the fetuses in the treated groups were smaller than the controls (-5% in E1-9 and -16% in E10-20, p less than 0.05); differences disappeared on the 13th day postpartum. Two fetuses from treated mothers presented incomplete skull ossification. We believe this report adds arguments to preclude converting enzyme inhibitors in pregnancy.
Valdés
G
G
Department of Nephrourology, School of Medicine, Catholic University, Santiago, Chile.
Marinovic
D
D
Falcón
C
C
Chuaqui
R
R
Duarte
I
I
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects; D004311:Double-Blind Method; D004656:Enalapril / Q000633:toxicity*; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D010920:Placenta / Q000002:abnormalities / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens
D013723:Teratogens; D004656:Enalapril