Formation of biologically active 13,14-dihydro-prostaglandin E1 during intravenous infusion of prostaglandin E1 in newborns with ductus arteriosus-dependent congenital heart disease.
Plasma concentrations of prostaglandin (PG) E1 (12-150, median 25 pg ml-1) and 13,14-dihydro-PGE1 (3-62, median 45.5 pg ml-1) were measured by gas chromatography-mass spectrometry in eight newborns with ductus arteriosus-dependent congenital heart disease during continuous intravenous infusion of PGE1. Formation of 13,14-dihydro-PGE1 was demonstrated for the first time in neonates. Since 13,14-dihydro-PGE1 has similar biological activities as the parent compound PGE1, pharmacological effects during PGE1 infusion are most likely related to both PGE1 and the generation and action of 13,14-dihydro-PGE1.
Leonhardt
A
A
Department of Paediatrics, University of Marburg, Germany.
Schweer
H
H
Wolf
D
D
Seyberth
H W
HW
D000527:Alprostadil / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000097:blood; D004374:Ductus Arteriosus, Patent / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn
C069881:13,14-dihydroprostaglandin E1; D000527:Alprostadil