title: Predictive value of testing random urine sample to detect microalbuminuria in diabetic subjects during outpatient visit.
abstract: The predictive value of random urine sample during outpatient visit to predict persistent microalbuminuria was studied in 76 Type 1, insulin-dependent diabetic subjects, 61 Type 2, non-insulin-dependent diabetic subjects, and 72 Type 2, insulin-treated diabetic subjects. Seventy-six patients attended outpatient clinic during morning, and 133 during afternoon. Microalbuminuria was suspected if Urinary Albumin Excretion (UAE) exceeded 20 mg/l. All patients were hospitalized within 6 months following outpatient visit, and persistent microalbuminuria was assessed then if UAE was between 30 and 300 mg/24 h on 2-3 occasions in 3 urines samples. Of these 209 subjects eighty-three were also screened with Microbumintest (Ames-Bayer), a semi-quantitative method. Among the 209 subjects, 71 were positive both for microalbuminuria during outpatient visit and a persistent microalbuminuria during hospitalization: sensitivity 91.0%, specificity 83.2%, concordance 86.1%, and positive predictive value 76.3% (chi-squared test: 191; p less than 10(-4)). Data were not different for subjects examined on morning, or on afternoon. Among the 83 subjects also screened with Microbumintest, 22 displayed both a positive reaction and a persistent microalbuminuria: sensitivity 76%, specificity 81%, concordance 80%, and positive predictive value 69% (chi-squared test: 126; p less than 10(-4)). Both types of screening appeared equally effective during outpatient visit. Hence, a persistent microalbuminuria can be predicted during an outpatient visit in a diabetic clinic.
authors.affiliation: Unité de Diabétologie, Centre Hospitalier Régional et Universitaire, Angers, France.
authors.forename: B
authors.initials: B
authors.lastname: Bouhanick
authors.forename: G
authors.initials: G
authors.lastname: Berrut
authors.forename: A M
authors.initials: AM
authors.lastname: Chameau
authors.forename: M
authors.initials: M
authors.lastname: Hallar
authors.forename: F
authors.initials: F
authors.lastname: Bled
authors.forename: B
authors.initials: B
authors.lastname: Chevet
authors.forename: J
authors.initials: J
authors.lastname: Vergely
authors.forename: V
authors.initials: V
authors.lastname: Rohmer
authors.forename: P
authors.initials: P
authors.lastname: Fressinaud
authors.forename: M
authors.initials: M
authors.lastname: Marre
mesh_terms: D000328:Adult; D000419:Albuminuria; D015415:Biomarkers / Q000652:urine; D003922:Diabetes Mellitus, Type 1 / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000652:urine*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006760:Hospitalization; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011379:Prognosis; D012016:Reference Values
chemical_list: D015415:Biomarkers; D007328:Insulin