Use of a specific cholecystokinin receptor antagonist (L-364,718) to determine the role of cholecystokinin on feeding and body weight in rats with obstructive jaundice.
We conducted a study to examine the role of cholecystokinin in feeding behavior and weight change in rats with obstructive jaundice. Daily food and water intake, body weight, and short-term food intake were determined in two groups of rats with surgically induced obstructive jaundice and in control rats. One group of rats with obstructive jaundice was given L-364,718, a selective cholecystokinin receptor antagonist. Plasma bilirubin and cholecystokinin levels were measured in each rat before and 7 days after surgery. Daily food intake and body weight were decreased in obstructive jaundice rats compared with control rats during the first week after surgery (P less than .05); however, obstructive jaundice rats treated with L-364,718 had increased food intake and body weight (P less than .05). Short-term food intake measured for 30 minutes and 120 minutes in food-deprived obstructive jaundice rats was decreased when compared with control rats (P less than .05), but the obstructive jaundice rats given L-364,718 had increased short-term food intake (P less than .05). Water intake was similar between the two groups of rats. Plasma levels of cholecystokinin and bilirubin were increased in obstructive jaundice rats with and without L-364,718 treatment (P less than .05). The results support the concept that endogenously elevated levels of plasma cholecystokinin play an important role in decreased food intake and subsequent loss of body weight in rats with obstructive jaundice.
Tangoku
A
A
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock 72205.
Doi
R
R
Chowdhury
P
P
Pasley
J N
JN
McKay
D W
DW
Rayford
P L
PL
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001663:Bilirubin / Q000097:blood; D001835:Body Weight; D002766:Cholecystokinin / Q000037:antagonists & inhibitors* / Q000097:blood / Q000502:physiology*; D002779:Cholestasis / Q000097:blood*; D020109:Devazepide; D005247:Feeding Behavior; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001570:Benzodiazepinones; D002766:Cholecystokinin; D020109:Devazepide; D001663:Bilirubin