title: Heart transplantation after mechanical circulatory support: four years' experience.
abstract: To determine the effect of mechanical circulatory support before heart transplantation, we conducted a retrospective analysis of 207 men who underwent staged orthotopic transplantations. Of these patients, 185 (group I) required pharmacologic support before transplantation; 14 (group II) required mechanical circulatory support with an intraaortic balloon pump (duration of support, 1 to 26 days); and eight (group III) required advanced mechanical circulatory support with an implantable left ventricular assist device (duration of support, 19 to 132 days). A comparison of complications after transplantation (infection and rejection), hospitalization, and survival showed that no significant differences existed among the three groups. In each group, respectively, 1-year survival was 80.9%, 77.3%, and 75%, and 2-year survival was 75.7%, 67.7%, and 75%. Based on our experience, patients receiving mechanical circulatory support before transplantation can be expected to have a good outcome. In fact, such support can help to improve their end-organ perfusion, and, thus, their status as heart transplantation candidates. Furthermore, this study shows that advanced mechanical circulatory support is possible even for prolonged periods, with low risk of sudden death. This finding is an important step toward development of a permanent assist device.
authors.affiliation: Cullen Cardiovascular Research Laboratories, Texas Heart Institute, Houston 77225-0345.
authors.forename: S
authors.initials: S
authors.lastname: Birovljev
authors.forename: B
authors.initials: B
authors.lastname: Radovancevic
authors.forename: C M
authors.initials: CM
authors.lastname: Burnett
authors.forename: J D
authors.initials: JD
authors.lastname: Vega
authors.forename: G
authors.initials: G
authors.lastname: Bennink
authors.forename: J L
authors.initials: JL
authors.lastname: Lonquist
authors.forename: J M
authors.initials: JM
authors.lastname: Duncan
authors.forename: O H
authors.initials: OH
authors.lastname: Frazier
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D006084:Graft Rejection; D016027:Heart Transplantation / Q000401:mortality*; D006353:Heart-Assist Devices; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007423:Intra-Aortic Balloon Pumping; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011300:Preoperative Care; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D007166:Immunosuppressive Agents