title: Does choice of the anesthetic influence renal function during infrarenal aortic surgery?
abstract: Reconstructive infrarenal aortic surgery is associated with impairment of renal function owing to vasoconstriction during and after aortic cross-clamping. To assess the influence of anesthetic technique on renal hemodynamics during aortic surgery, 34 patients received one of four anesthetics: isoflurane (n = 10), halothane (n = 9), droperidol (n = 8), and flunitrazepam (n = 7). Supplemental anesthesia consisted of midazolam, fentanyl, nitrous oxide in oxygen (50%), and pancuronium. Before aortic cross-clamping, effective renal plasma flow (ERPF) (131iodohippuran clearance) and glomerular filtration rate (GFR) (99technetium-DTPA clearance) were low in the halothane and flunitrazepam groups (118.4 +/- 25.6 and 170 +/- 35 mL/min for ERPF; 19.7 +/- 5.2 and 26.9 +/- 5.8 mL/min for GFR, respectively) and better preserved in the isoflurane group (253.4 +/- 51.5 and 44.9 +/- 8.4 mL/min, respectively; P less than 0.05 between isoflurane and halothane groups) or in the droperidol group as regards GFR (75.4 +/- 9.4 mL/min, P less than 0.05). During clamping, both renal variables were not markedly affected in any group except in the droperidol group in whom GFR significantly decreased from preclamp value. The GFR was then significantly higher in the isoflurane group (49.5 +/- 9.2 mL/min) than in the halothane and flunitrazepam groups (14.8 +/- 3.7 and 26.5 +/- 10.1 mL/min, respectively; P less than 0.05). After aortic declamping, ERPF and GFR increased markedly in the halothane group, and there was no significant difference between the groups. These results suggest that renal hemodynamics are less altered with droperidol-fentanyl anesthesia during abdominal surgery but not during aortic cross-clamping.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, Hôpital St-Eloi, Centre Hospitalo-Universitaire, Montpellier, France.
authors.forename: P
authors.initials: P
authors.lastname: Colson
authors.forename: X
authors.initials: X
authors.lastname: Capdevilla
authors.forename: D
authors.initials: D
authors.lastname: Cuchet
authors.forename: M
authors.initials: M
authors.lastname: Saussine
authors.forename: J R
authors.initials: JR
authors.lastname: Séguin
authors.forename: C
authors.initials: C
authors.lastname: Marty-Anè
authors.forename: B
authors.initials: B
authors.lastname: Roquefeuil
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000777:Anesthetics; D001012:Aorta, Abdominal / Q000601:surgery*; D004329:Droperidol; D005260:Female; D005283:Fentanyl; D005445:Flunitrazepam; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006221:Halothane; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007530:Isoflurane; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012079:Renal Circulation / Q000187:drug effects
chemical_list: D000777:Anesthetics; D005445:Flunitrazepam; D007530:Isoflurane; D004329:Droperidol; D005283:Fentanyl; D006221:Halothane