title: Differential activity of bacteriocins and cefotaxime against Serratia marcescens clinical isolate SMG40 and its pigmented variant.
abstract: Strain Serratia marcescens SMG40 was nonpigmented but yielded pigmented variants at low frequency. Of 15 tested bacteriocins, 10 were active against the original strain, but only 7 were active against the pigmented variant Pdg+. Moreover, active cephalosporins, e.g., cefotaxime, were more active against the Pdg+ variant than against strain SMG40. These reciprocal differences in susceptibility to some bacteriocins and to cefotaxime were maintained in subclones derived from Pdg+/- sectored colonies. However, mutants of pigmentation isolated from the Pdg+ variant were not modified with regard to bacteriocins and cefotaxime. Other clinical isolates of Serratia were examined for comparison, but strain SMG40 appeared to be unique.
authors.affiliation: Laboratory of Microbiology, Brussels University School of Medicine, Belgium.
authors.forename: J P
authors.initials: JP
authors.lastname: Gratia
authors.forename: L
authors.initials: L
authors.lastname: Crenier
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D001430:Bacteriocins / Q000494:pharmacology*; D002439:Cefotaxime / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010860:Pigments, Biological; D010878:Piperacillin / Q000494:pharmacology; D012706:Serratia marcescens / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D001430:Bacteriocins; D002511:Cephalosporins; D010860:Pigments, Biological; D000658:Amoxicillin; D002439:Cefotaxime; D002444:Cefuroxime; D010878:Piperacillin