The analysis of 10 potential spindle poisons for their ability to induce CREST-positive micronuclei in human diploid fibroblasts.
Ten compounds selected for use within a coordinated Commission of the European Communities programme on aneuploidy induction (cadmium chloride, chloral hydrate, colchicine, diazepam, econazole, hydroquinone, pyrimethamine, thiabendazole, thimerosal and vinblastine) were tested for their ability to induce CREST-positive micronuclei in cultured human diploid fibroblasts. Significant increases in CREST-positive micronuclei were produced by cadmium chloride, chloral hydrate, colchicine, diazepam and vinblastine. Thiabendazole produced a significant increase in the ratio of CREST-positive to CREST-negative micronuclei and was also classified as positive. Colchicine, diazepam and chloral hydrate were also tested in V79 Chinese hamster cells, where they all induced CREST-positive micronuclei.
Bonatti
S
S
National Institute for Research on Cancer, Genova, Italy.
Cavalieri
Z
Z
Viaggi
S
S
Abbondandolo
A
A
D000782:Aneuploidy; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004171:Diploidy; D005069:Evaluation Studies as Topic; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity; D012595:Scleroderma, Systemic / Q000276:immunology
D009153:Mutagens