Circulating concentrations and pattern of luteinizing hormone and follicle-stimulating hormone in circulation are changed by the circulating concentration of 17 beta-estradiol in the bovine male and female.
The objectives of the present study were 1) to determine whether 17 beta-estradiol (E2) regulation of tonic secretion of LH and FSH is sexually differentiated in the bovine and 2) to evaluate the effects of various physiological concentrations of E2 on the profiles and concentrations of gonadotropins in circulation. This was accomplished by administering different numbers of implants containing E2 to gonadectomized bovine males and females. Mean age at initiation of the study was 18.5 mo. Animals received 1, 2, 4, 8, or 16 implants of E2 or a sham implantation. Mean concentrations of LH in circulation and amplitude of LH pulses were similar between males and females after administration of E2. There was a cubic response for mean concentrations of LH and amplitudes of LH pulses across the dosages of E2 administered; lower concentrations of E2 had little effect, whereas higher concentrations of E2 suppressed both mean LH and amplitude of LH pulses. A linear decline in frequency of LH pulses occurred as concentrations of E2 in circulation increased. A treatment x sex interaction resulted for mean concentrations of FSH in circulation. Low doses of E2 resulted in a greater enhancement of circulating concentrations of FSH in males than in females. Tonic secretion of LH in bovine males and females responded in a similar manner to administration of various physiological concentrations of E2; however, a differential response between sexes was observed for FSH.
Wolfe
M W
MW
Department of Animal Science, University of Nebraska, Lincoln 68583-0908.
Roberson
M S
MS
Stumpf
T T
TT
Kittok
R J
RJ
Kinder
J E
JE
D000818:Animals; D002369:Castration / Q000662:veterinary; D002417:Cattle / Q000097:blood / Q000502:physiology*; D004343:Drug Implants; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D008297:Male; D012727:Sex Characteristics
D004343:Drug Implants; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone