[Scintigraphic evaluation of the peak systolic pressure-end-systolic volume relation: comparison with invasive left ventricular contractile indexes].
We calculated the slope of peak systolic pressure-end-systolic volume relation (P/V slope) and the ratio of peak systolic pressure to end-systolic volume (P/V ratio) using radionuclide ventriculography and indirect sphygmomanometry to evaluate left ventricular contractility, and to assess the usefulness of these indexes, we compared them with mean VCF, LVEF, ESVI and ESS/ESVI using cardiac catheterization. Subjects were 12 patients who had received both radionuclide ventriculography and cardiac catheterization within a two weeks period. Left ventricular end-systolic volume and peak blood pressure were measured at 3 different points, one in the control state and the other two at two different hemodynamic states during infusion of Methoxamine. We defined P/V slope as the slope of the regression line of peak systolic pressure-end-systolic volume relation, and P/V ratio as the ratio of peak systolic pressure to left ventricular end-systolic volume at control. Left ventricular volume was measured by the non-gated-SPECT method and changes of the left ventricular volume was measured by the multigate method. P/V slope was correlated exponentially with mean VCF, LVEF and ESVI (y = 0.34.e1.9x, r = 0.86, p less than 0.001 for mean VCF; y = 0.25.e0.041x, r = 0.83, p less than 0.001 for LVEF; y = 7.8.e-0.028x, r = 0.88, p less than 0.001 for ESVI), and correlated linearly with ESS/ESVI (y = 1.6x-3.7, r = 0.88, p less than 0.001). P/V ratio was also correlated exponentially with mean VCF, LVEF and ESVI (y = 0.47.e1.4x, r = 0.86, p less than 0.001 for mean VCF; y = 0.35.e0.032x, r = 0.86, p less than 0.001 for LVEF; y = 4.8.e-0.021x, r = 0.87, p less than 0.001 for ESVI), and correlated linearly with ESS/ESVI (y = 1.2x-2.6, r = 0.83, p less than 0.001). We concluded that P/V slope and P/V ratio were useful indexes to evaluate left ventricular contractility noninvasively.
Yamamoto
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First Department of Internal Medicine, Niigata University School of Medicine.
D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization; D002306:Cardiac Volume; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D015637:Gated Blood-Pool Imaging; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D013599:Systole; D016277:Ventricular Function, Left