title: Comparison of cysteine-proteinases inhibitory properties of human high-molecular-weight-kininogen (HMrK) purified from plasma and serum.
abstract: We have purified both plasma and serum High Molecular Weight Kininogens (HMrK) and studied their inhibitory properties against members of the cysteine proteinases super-family. The clotting pathway liberates two different fragments by limited proteolysis of HMrK. The inhibitory properties of these fragments against the cysteine proteinases of the papain super-family are conserved after blood clotting, i.e. when the procoagulant domain of HMrK was destroyed.
authors.affiliation: Laboratoire de Biochimie, Faculté de Medecine, Broussais Hotel-Dieu, Université Pierre et Marie Curie, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Pagano
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D006801:Humans; D007704:Kininogens / Q000097:blood / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D015853:Cysteine Proteinase Inhibitors; D007704:Kininogens