title: [A case report of Candida prosthetic endocarditis: an autopsy review].
abstract: Most of the increasing numbers of cases of Candida endocarditis have developed after cardiac surgery. We report a case of Candida parapsilosis endocarditis after mitral valve replacement in a patient with no predisposing factors. In this report we mainly examined the pathological findings in this patient with postmortem examination. A woman, age 55, underwent valve replacement with a Björk-Shiley prosthesis for mitral stenosis. The spike fever occurred on the 22nd postoperative day and Candida parapsilosis was cultured from the blood. On the 76th day, a conscious disturbance with the right side hemiplegia was experienced. A CT scan revealed massive hemorrhagic infarction. Despite the intensive care the patient died of cerebral damage. Pathologic findings showed that the vegetation in the major orifice of the Björk-Shiley valve was composed of both necrotic debris and tissue, with Candida organisms being scattered throughout the interstices. Additionally there were also multiple myocardial abscesses with necrotic tissue.
authors.affiliation: Department of Cardiovascular Surgery, Osaka National Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Otaki
authors.forename: M
authors.initials: M
authors.lastname: Kawashima
authors.forename: A
authors.initials: A
authors.lastname: Yamaguchi
authors.forename: N
authors.initials: N
authors.lastname: Kitamura
mesh_terms: D002177:Candidiasis; D004696:Endocarditis / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve; D016459:Prosthesis-Related Infections / Q000382:microbiology* / Q000473:pathology