title: Chemical and in vivo studies of interaction between cadmium and vitamin B6.
abstract: The interaction of vitamin B6 pyridoxine with cadmium acetate in ethanolic solution has been studied. The new compound Cd(PN-H)(OOCCH3) (PN-H = pyridoxinato anion) was isolated and its structure studied in the solid state by IR and 13C and 113Cd CP/MAS NMR spectroscopies. The effect of pyridoxine on survival rate among male Sprague rats injected intraperitoneally with 5 mg CdCl2.H2O/kg was also investigated. Vitamin treatment seems to increase (Protocol C) or does not affect the cadmium lethality. Although the analysis of the metal burden in some organs seems to suggest a light increase of the cadmium level in the liver, this change has no significance at a statistical level.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Galicia, Spain.
authors.forename: M D
authors.initials: MD
authors.lastname: Couce
authors.forename: J M
authors.initials: JM
authors.lastname: Varela
authors.forename: A
authors.initials: A
authors.lastname: Sánchez
authors.forename: J S
authors.initials: JS
authors.lastname: Casas
authors.forename: J
authors.initials: J
authors.lastname: Sordo
authors.forename: M
authors.initials: M
authors.lastname: López-Rivadulla
mesh_terms: D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D019256:Cadmium Chloride; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity; D004347:Drug Interactions; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011736:Pyridoxine / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013055:Spectrophotometry, Infrared
chemical_list: D002712:Chlorides; D002104:Cadmium; D019256:Cadmium Chloride; D011736:Pyridoxine