title: Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat.
abstract: Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU.
authors.affiliation: Doheny Eye Institute, Los Angeles, CA.
authors.forename: J
authors.initials: J
authors.lastname: Semel
authors.forename: B
authors.initials: B
authors.lastname: Bowe
authors.forename: A
authors.initials: A
authors.lastname: Guo
authors.forename: L
authors.initials: L
authors.lastname: Lee
authors.forename: L
authors.initials: L
authors.lastname: Rife
authors.forename: D
authors.initials: D
authors.lastname: Polikoff
authors.forename: P
authors.initials: P
authors.lastname: Summanen
authors.forename: G
authors.initials: G
authors.lastname: Pararajasegaram
authors.forename: S M
authors.initials: SM
authors.lastname: Finegold
authors.forename: N
authors.initials: N
authors.lastname: Rao
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D003459:Crystallins / Q000276:immunology*; D004195:Disease Models, Animal; D005620:Freund's Adjuvant; D006099:Granuloma / Q000276:immunology / Q000473:pathology; D007903:Lens Capsule, Crystalline / Q000601:surgery; D007905:Lens Diseases / Q000276:immunology* / Q000473:pathology; D008297:Male; D011425:Propionibacterium acnes / Q000276:immunology*; D051381:Rats; D014605:Uveitis / Q000276:immunology* / Q000473:pathology
chemical_list: D000276:Adjuvants, Immunologic; D003459:Crystallins; D005620:Freund's Adjuvant