title: Analysis of upstream sequences of the human estrogen receptor gene.
abstract: An upstream region of the human estrogen receptor gene (ER) spanning from -2776 to -38 in relation to a previously described exon 1 was sequenced and analyzed for the possible presence of open reading frames (ORF) and regulatory motifs. We identified a long 459 bp ORF beginning at -2301. Most of the transcriptional regulatory motifs present within the ER upstream sequence are distributed either upstream or downstream of this long ORF which displays a TATA box, a CACC motif and a canonical cap site in the 5' flanking region.
authors.affiliation: Istituto di Chimica Biologica, Università degli Studi di Ferrara, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Piva
authors.forename: R
authors.initials: R
authors.lastname: Gambari
authors.forename: F
authors.initials: F
authors.lastname: Zorzato
authors.forename: L
authors.initials: L
authors.lastname: Kumar
authors.forename: L
authors.initials: L
authors.lastname: del Senno
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D006801:Humans; D008969:Molecular Sequence Data; D016364:Reading Frames; D011960:Receptors, Estrogen / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D011960:Receptors, Estrogen