title: High-performance liquid chromatographic method for the analysis of Oltipraz in human serum and urine.
abstract: A rapid, sensitive procedure for the analysis of Oltipraz in serum and urine using high-performance liquid chromatography was developed. The proposed method illustrates recovery of Oltipraz from biological fluids was greater than 80%. Detection and separation of Oltipraz required as little as 1 ml of serum or urine. Oltipraz was detectable when 2 ng or more of drug was present in 1 ml of serum or urine; the method is highly reproducible when 5 ng/ml or more Oltipraz is present in the biological fluid.
authors.affiliation: Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317.
authors.forename: J L
authors.initials: JL
authors.lastname: Bennett
authors.forename: J
authors.initials: J
authors.lastname: McMillan
authors.forename: N V
authors.initials: NV
authors.lastname: Dimitrov
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D011719:Pyrazines / Q000032:analysis* / Q000097:blood / Q000652:urine; D011786:Quality Control; D012015:Reference Standards; D013871:Thiones; D013876:Thiophenes
chemical_list: D011719:Pyrazines; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz