title: Enhanced ingrowth of porous-coated CoCr implants plasma-sprayed with tricalcium phosphate.
abstract: Tricalcium phosphate (TCP) is an osteo-conductive bioceramic which, when applied to a porous-coated prosthesis, may enhance osseous ingrowth and mechanical stability. TCP plasma-sprayed and unsprayed porous-coated tibial intramedullary rods were bilaterally implanted in seven adult rabbits. All rabbits were killed at 12 weeks. Pull-out tests were performed on 4 rabbits while all were evaluated histologically for osseous response and adverse tissue reaction. TCP-sprayed implants showed significantly greater osseous ingrowth in comparison to unsprayed implants. Neither implant type exhibited adverse tissue reactions. Average pull-out strengths were 69 lb for treated rods and 72 lb for controls (p greater than 0.05); quality of fit for all pull-out specimens except one was deemed poor. We conclude that plasma-sprayed TCP enhances osseous ingrowth into porous-coated devices. However, our data further suggest that enhanced ingrowth may not always lead to enhanced fixation.
authors.affiliation: Dartmouth Biomedical Engineering Center, Hanover, New Hampshire 03756.
authors.forename: J C
authors.initials: JC
authors.lastname: Chae
authors.forename: J P
authors.initials: JP
authors.lastname: Collier
authors.forename: M B
authors.initials: MB
authors.lastname: Mayor
authors.forename: V A
authors.initials: VA
authors.lastname: Surprenant
authors.forename: L A
authors.initials: LA
authors.lastname: Dauphinais
mesh_terms: D000497:Alloys; D000818:Animals; D001846:Bone Development / Q000187:drug effects*; D002130:Calcium Phosphates / Q000494:pharmacology*; D002858:Chromium Alloys; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D011817:Rabbits; D013977:Tibia / Q000473:pathology / Q000502:physiology
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D002858:Chromium Alloys; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous