title: Prodromal symptoms and signs of bipolar relapse: a report based on prospectively collected data.
abstract: Prospectively collected data on 19 recently hospitalized patients with bipolar disorder were examined for prodromal changes preceding relapse. The 4-month periods before six manic and six depressive relapses were compared with each other and with a comparable period for seven patients who did not relapse. The Brief Psychiatric Rating Scale was used to assess symptoms. Significant elevations in unusual thought content were found 1 month before manic relapse. Depressive relapsers evidenced higher levels of conceptual disorganization throughout the prerelapse period. Nonrelapsers showed very stable symptom profiles.
authors.affiliation: Department of Psychology, University of California, Los Angeles 90024-1563.
authors.forename: E S
authors.initials: ES
authors.lastname: Altman
authors.forename: M M
authors.initials: MM
authors.lastname: Rea
authors.forename: J
authors.initials: J
authors.lastname: Mintz
authors.forename: D J
authors.initials: DJ
authors.lastname: Miklowitz
authors.forename: M J
authors.initials: MJ
authors.lastname: Goldstein
authors.forename: S
authors.initials: S
authors.lastname: Hwang
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data*; D011594:Psychometrics; D012008:Recurrence