title: [Clinical evaluation of 123I-BMIPP myocardial scintigraphy in patients with hypertrophic cardiomyopathy].
abstract: 123I-BMIPP myocardial scintigraphy was performed in 13 patients with hypertrophic cardiomyopathy and compared with 201Tl myocardial scintigraphy performed within 3 months for evaluating the clinical significance of 123I-BMIPP myocardial scintigraphy. SPECT images were divided into 13 segments and segmental images were visually scored on a 4 (increased tracer uptake) to 0 (severely decreased tracer uptake) scale according to the tracer uptake. In comparison of 123I-BMIPP early images and 201Tl perfusion images, mismatches were seen in about 70% of all segments. The number of segments demonstrating lower myocardial uptake of 123I-BMIPP was larger than that of 201Tl. In hypertrophic regions, the tracer uptake of 123I-BMIPP early images was significantly lower than that of 201Tl images and the lower uptake of 123I-BMIPP delayed images was more marked. In non-hypertrophic regions, no significant difference was seen between the tracer uptakes of 123I-BMIPP early images and 201Tl images but the tracer uptake of 123I-BMIPP delayed images was significantly lower than that of 201Tl images. The mismatch between the tracer uptakes of 123I-BMIPP images and 201Tl images was thought to be a reflection of disordered myocardial fatty acid metabolism. "Washout", the difference between the tracer uptakes of 123I-BMIPP early images and delayed images was also thought to be a reflection of disordered myocardial fatty acid metabolism. These results suggest that 123I-BMIPP is a promising radiopharmaceutical for evaluating disordered myocardial fatty acid metabolism in patients with HCM.
authors.affiliation: Second Department of Medicine, Kyoto Prefectural University of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Ohtsuki
authors.forename: H
authors.initials: H
authors.lastname: Sugihara
authors.forename: I
authors.initials: I
authors.lastname: Umamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Shiga
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: A
authors.initials: A
authors.lastname: Azuma
authors.forename: Y
authors.initials: Y
authors.lastname: Kohno
authors.forename: H
authors.initials: H
authors.lastname: Katsume
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D007462:Iodobenzenes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D013793:Thallium / Q000493:pharmacokinetics; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid; D013793:Thallium