title: Recombinant human erythropoietin is effective in correcting erythropoietin-deficient anaemia after allogeneic bone marrow transplantation.
abstract: Two children affected by severe aplastic anaemia (SAA) underwent allogeneic bone marrow transplantation (BMT) using partially matched family donors. In both cases there was a successful engraftment of donor haemopoietic stem cells. However, after an initial erythropoietic recovery, 5 months following BMT both children became severely anaemic. Although multiple factors were responsible for anaemia, in both cases there was a markedly impaired erythropoietin response to anaemia, as indicated by the inappropriately low levels of serum erythropoietin (EPO). Treatment with recombinant human erythropoietin (rHuEPO) induced a sustained erythropoietic response with complete correction of anaemia. This pilot study suggests that rHuEPO can be effective in correcting long-lasting anaemia after marrow transplantation, characterized by inadequate erythropoietin production.
authors.affiliation: Clinica Pediatrica, Università di Pavia, I.R.C.C.S. Policlinico San Matteo, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
authors.forename: P
authors.initials: P
authors.lastname: Pedrazzoli
authors.forename: G
authors.initials: G
authors.lastname: Barosi
authors.forename: M
authors.initials: M
authors.lastname: Zecca
authors.forename: F
authors.initials: F
authors.lastname: Porta
authors.forename: L
authors.initials: L
authors.lastname: Liberato
authors.forename: D
authors.initials: D
authors.lastname: Gambarana
authors.forename: L
authors.initials: L
authors.lastname: Nespoli
authors.forename: M
authors.initials: M
authors.lastname: Cazzola
mesh_terms: D000740:Anemia / Q000097:blood / Q000188:drug therapy*; D000741:Anemia, Aplastic / Q000601:surgery; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002675:Child, Preschool; D004921:Erythropoietin / Q000097:blood / Q000172:deficiency* / Q000627:therapeutic use*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D010865:Pilot Projects; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin