Relationship between interleukin 6, agalactosyl IgG and pristane-induced arthritis.
IL-6 titres in sera and peritoneal exudate fluids (PEF) derived from pristane injected DBA/1 and CBA/Igb mice were measured. Arthritic DBA/1 mice had significantly higher serum IL-6 titres than nonarthritic or normal mice at 160 days post pristane injection. By contrast, although both arthritic and non-arthritic CBA/Igb mice had higher serum IL-6 titres than normal mice, there was no significant difference in serum IL-6 titre between these two groups at day 200-230. In both strains of mice, the IL-6 titres in PEF were more than 10 times serum levels regardless of arthritis. As previously reported for CBA/Igb mice, agalactosyl IgG levels are raised in pristane injected DBA/1 mice and the percentage is higher in arthritic animals than that in non-arthritic mice. An association between serum agalactosyl IgG levels and PEF IL-6 in pristane injected DBA/1 was demonstrated. Moreover, the injection of recombinant IL-6 into normal mice increased their serum agalactosyl IgG levels. However, it is considered that IL-6 is not the only factor involved in the production of agalactosyl IgG.
Hitsumoto
Y
Y
Department of Pathology and Microbiology, School of Medical Science, University of Bristol, UK.
Thompson
S J
SJ
Zhang
Y W
YW
Rook
G A
GA
Elson
C J
CJ
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D004195:Disease Models, Animal; D005122:Exudates and Transudates / Q000737:chemistry; D006031:Glycosylation; D007074:Immunoglobulin G / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013729:Terpenes
D007074:Immunoglobulin G; D015850:Interleukin-6; D013729:Terpenes; C064155:agalactosyl IGG; C009042:pristane