title: Angular deformity of the lower extremity in children with renal osteodystrophy.
abstract: We have treated 15 children with end-stage renal disease (ESRD), renal osteodystrophy, and genu valgum in the last 22 years. In a retrospective review, we determined that periods of metabolic instability, best characterized as an alkaline phosphatase of 500 U for at least 10 months, were associated with progression of deformity. Histomorphometric bone biopsy provided information that proved essential for effective evaluation and treatment in this group. Complications of corrective osteotomy were related to perioperative metabolic instability. A surgical treatment protocol is described, emphasizing preoperative assessment by histomorphometric bone biopsy and multimodal medical management to maintain metabolic stability perioperatively.
authors.affiliation: Department of Orthopaedics, University of Colorado Health Science Center, Denver.
authors.forename: J R
authors.initials: JR
authors.lastname: Davids
authors.forename: R
authors.initials: R
authors.lastname: Fisher
authors.forename: G
authors.initials: G
authors.lastname: Lum
authors.forename: S
authors.initials: S
authors.lastname: Von Glinski
mesh_terms: D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001706:Biopsy; D001842:Bone and Bones / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications*; D006801:Humans; D016916:Joint Deformities, Acquired / Q000201:enzymology / Q000601:surgery*; D010027:Osteotomy / Q000379:methods*; D012189:Retrospective Studies
chemical_list: D000469:Alkaline Phosphatase