title: Salmonella typhimurium enterotoxin mediated fluid secretion.
abstract: Unidirectional Na+ and Cl- fluxes were studied in rats treated with S. typhimurium enterotoxin (S-LT). There was net absorption of Na+ and Cl- in the control group, while in the toxin treated animals there was net secretion of Na+ and Cl- (P less than 0.001). There was no change in the transport of D-glucose in the toxin treated group as compared to the control animals. The Na+, K(+)-ATPase pump was unaltered in the S-LT treated animals (198.67 +/- 11.23 nmoles Pi/mg protein/min) as compared to the control group (189.93 +/- 10.09 nmoles Pi/mg protein/min). There was no change in the unidirectional fluxes of Ca+2 in the S-LT treated animals as compared to the control animals, suggesting no change in the permeability of the S-LT treated intestinal membrane to Ca+2.
authors.affiliation: Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh.
authors.forename: S
authors.initials: S
authors.lastname: Khurana
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
authors.forename: D
authors.initials: D
authors.lastname: Panigrahi
authors.forename: M
authors.initials: M
authors.lastname: Khullar
authors.forename: B N
authors.initials: BN
authors.lastname: Walia
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D004731:Endotoxins; D004768:Enterotoxins / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D001427:Bacterial Toxins; D002712:Chlorides; D004731:Endotoxins; D004768:Enterotoxins; C027952:salmonella toxin; D012964:Sodium; D002118:Calcium