Molecular sequence accuracy: analysing imperfect data.
Molecular sequences are experimentally derived data that can be expected to contain errors as a result of diverse phenomena such as biological variation, molecular cloning artifacts, imperfect sequence determination, and data handling during contig assembly. Errors will affect the reliability of database searches and sequence alignments, but their impact may be minimized by the use of analytical techniques that anticipate that the data will be imperfect.
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National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894.
D000595:Amino Acid Sequence; D003627:Data Interpretation, Statistical; D008969:Molecular Sequence Data; D015203:Reproducibility of Results