title: Multiple-fibre low-power interstitial laser hyperthermia: studies in the normal liver.
abstract: Multiple four-fibre low-power interstitial laser hyperthermia was performed in the canine liver to establish the parameters with which large areas of thermal necrosis could be made. Using 1.5 W for 670 s (4020 J in total) and a fibre spacing of 1.5 cm, lesions with dimensions of 3.6 x 3.1 x 2.8 cm were achieved in 75 per cent of those attempted. There was no mortality and a low morbidity rate. These lesions could be visualized in both their development and resolution using ultrasonography. Healing occurred by 1 year. Temperatures in the centre of the heated region were 60 degrees C, which is more than enough to cause thermal cell death. There was good correlation between the temperatures recorded, the sonographic changes seen, and the pathological evidence of necrosis. Multiple-fibre low-power interstitial laser hyperthermia performed with ultrasonic guidance may be of use in the treatment of liver tumours.
authors.affiliation: National Medical Laser Centre, University College and Middlesex Hospital Medical School, London, UK.
authors.forename: A C
authors.initials: AC
authors.lastname: Steger
authors.forename: W R
authors.initials: WR
authors.lastname: Lees
authors.forename: P
authors.initials: P
authors.lastname: Shorvon
authors.forename: K
authors.initials: K
authors.lastname: Walmsley
authors.forename: S G
authors.initials: SG
authors.lastname: Bown
mesh_terms: D000818:Animals; D004285:Dogs; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007834:Lasers; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D009336:Necrosis; D013997:Time Factors; D014463:Ultrasonography