title: [Influence of extrinsic denervation of the pancreas on food-stimulated pancreas secretion and cholecystokinin and neurotensin release in the dog].
abstract: In the present study we examined the effect of extrinsic pancreatic denervation on meal-stimulated pancreatic exocrine secretion and the release of neurotensin and CCK in dogs. Denervation of the pancreas significantly decreased protein output from preoperatively 16,661 +/- 1824 mg x 150 min to 2033 +/- 316 mg x 150 min postoperatively (p less than 0.001), and bicarbonate secretion from 297.5 +/- 36 mmol x 150 min to 104.85 +/- 16 mmol x 150 min (p less than 0.01). Release of neurotensin and CCK was not altered by interruption of the extrinsic pancreatic nerves. Our findings are consistent with the hypothesis that pancreatic secretory response to a meal is predominantly mediated by neutral extrinsic reflexes.
authors.affiliation: Klinik und Poliklinik für Allgemeinchirurgie im Zentrum Chirurgie, Universität Göttingen.
authors.forename: H
authors.initials: H
authors.lastname: Köhler
authors.forename: R
authors.initials: R
authors.lastname: Nustede
authors.forename: M
authors.initials: M
authors.lastname: Barthel
authors.forename: A
authors.initials: A
authors.lastname: Schafmayer
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000493:pharmacokinetics; D002766:Cholecystokinin / Q000097:blood*; D003714:Denervation; D004285:Dogs; D005260:Female; D005502:Food; D007328:Insulin / Q000378:metabolism; D008297:Male; D009496:Neurotensin / Q000097:blood*; D010179:Pancreas / Q000294:innervation / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D011506:Proteins / Q000378:metabolism
chemical_list: D001639:Bicarbonates; D007328:Insulin; D011506:Proteins; D009496:Neurotensin; D002766:Cholecystokinin
vernacular_title: Einfluss der extrinsischen Denervation des Pankreas auf die nahrungsstimulierte Pankreassekretion und die Freisetzung von Cholezystokinin (CCK) und Neurotensin beim Hund.