title: Technetium-99m HM-PAO single photon emission computed tomography imaging in transient global amnesia.
abstract: Five right-handed patients with pure transient global amnesia were evaluated with technetium-99m hexamethylpropyleneamine oxime single photon emission computed tomography after the amnesic attack. Independent of the interval between the procedure and the amnesic episode, single photon emission computed tomography demonstrated a decreased cerebral blood flow in the left temporal lobe in one patient and in the left parietotemporal region in three patients, with a more marked reduction in the temporal lobe. The remaining three patients were normal. A control single photon emission computed tomographic study was carried out in one patient 3 months after the amnesic attack and showed a left-sided persistent temporal hypoperfusion. These findings suggest that in some patients, transient global amnesia can be due to a vascular mechanism requiring strong investigations for vascular risk factors and appropriate treatment. During a follow-up period of 12 to 32 months, none of the patients with regional hypoperfusion suffered cerebrovascular events, suggesting that single photon emission computed tomography has no predictive value for further stroke.
authors.affiliation: Department of Neurology, Mont-Godinne Hospital, University of Louvain, Yvoir, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Laloux
authors.forename: C
authors.initials: C
authors.lastname: Brichant
authors.forename: F
authors.initials: F
authors.lastname: Cauwe
authors.forename: P
authors.initials: P
authors.lastname: Decoster
mesh_terms: D000368:Aged; D000647:Amnesia / Q000000981:diagnostic imaging*; D001921:Brain / Q000098:blood supply; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D010091:Oximes; D010296:Parietal Lobe / Q000000981:diagnostic imaging; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime