title: [The effect of calcium antagonists on total calcium and magnesium levels in the aorta of rabbits after administration of dietary cholesterol].
abstract: The objective of the work was to investigate the effect of calcium blockers--dilthiazem (2 mg.kg-1.day-1), isradipine (2.5 mg.kg-1.day-1) and verapamil (0.25 mg.kg-1.day-1) on the calcium and magnesium content of the rabbit aorta with experimental atherosclerosis induced by a 1% cholesterol diet. In the aorta of rabbits kept on a cholesterol diet the calcium and magnesium content, as compared with a control group on a ordinary diet, increased significantly. In the experimental groups to whom during the eight-week period on the cholesterol diet at regular 12-hour intervals calcium antagonists were administered the calcium and magnesium content of the aorta reached normal levels. The antiatherogenic effect was, however, produced only by verapamil when administered in therapeutic doses.
authors.affiliation: Katedra farmakológie Lekárskej fakulty Univerzity Komenského, Bratislava.
authors.forename: E
authors.initials: E
authors.lastname: Drábková
authors.forename: Z
authors.initials: Z
authors.lastname: Lazarová
authors.forename: S
authors.initials: S
authors.lastname: Edelsteinová
authors.forename: A
authors.initials: A
authors.lastname: Czirfusz
authors.forename: J
authors.initials: J
authors.lastname: Gratzlová
authors.forename: P
authors.initials: P
authors.lastname: Holub
mesh_terms: D000818:Animals; D001011:Aorta / Q000737:chemistry*; D001161:Arteriosclerosis / Q000378:metabolism*; D002118:Calcium / Q000032:analysis*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008274:Magnesium / Q000032:analysis*; D008297:Male; D011817:Rabbits
chemical_list: D002121:Calcium Channel Blockers; D002791:Cholesterol, Dietary; D008274:Magnesium; D002118:Calcium
vernacular_title: Vplyv kalciových antagonistov na celkový obsah vápnika a horcíka v aorte králikov po podávaní cholesterolovej diéty.