DNA polymerase epsilon: in search of a function.
The current model of eukaryotic DNA replication involves the two DNA polymerases delta and alpha as the leading and lagging strand enzymes, respectively. A DNA polymerase first discovered in yeast has now been found in all eukaryotic cells and is termed DNA polymerase epsilon. In yeast, the gene for DNA polymerase epsilon has recently been found to be essential for viability, raising new questions about its functions.
Hübscher
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Department of Pharmacology and Biochemistry, University of Zürich-Irchel, Switzerland.
Thömmes
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D000818:Animals; D004258:DNA Polymerase III; D004260:DNA Repair / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology
D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase