title: The effect of indomethacin on anthralin inflammation.
abstract: The effect of prostaglandin inhibition, using topical indomethacin, on anthralin inflammation was studied. Indomethacin gel and gel base were applied to opposite flexor forearm skin sites of 11 volunteers for 2 h and then washed off. Anthralin and UVB were then applied to the gel-treated skin and the anthralin- and UVB-induced erythema and oedema were measured at 2, 6, 24 and 48 h using Harpenden callipers and a reflectance erythrometer. Prostaglandin inhibition was demonstrated by a significant reduction of UVB erythema at the indomethacin-treated sites compared to the gel-base-treated sites. There was a small but significant reduction in anthralin erythema, but not oedema, at the indomethacin-treated sites compared to the gel-base sites. This study demonstrates that prostaglandins, and other inflammatory mediators because the inhibitory effect was small, are involved in anthralin inflammation.
authors.affiliation: Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
authors.forename: B
authors.initials: B
authors.lastname: Ramsay
authors.forename: N
authors.initials: N
authors.lastname: Rice
authors.forename: C
authors.initials: C
authors.lastname: Lawrence
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000875:Anthralin / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000517:prevention & control*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D004890:Erythema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D005782:Gels; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D005782:Gels; D000875:Anthralin; D007213:Indomethacin