title: Bacterial adherence to plain and tobramycin-laden polymethylmethacrylate beads.
abstract: Antibiotic-impregnated polymethylmethacrylate (PMMA) bead chains are in current clinical use for prophylaxis and management of osteomyelitis. The in vivo interaction between PMMA beads and an experimentally infected wound is examined. Two modes of bacterial adherence to plain PMMA beads are demonstrated. In this report, tobramycin-sensitive bacteria did not attach to tobramycin-laden beads. Therefore, implanted PMMA beads should contain an antibiotic to which the infecting bacteria is sensitive.
authors.affiliation: Department of Orthopaedic Surgery, University of Louisville, KY 40292.
authors.forename: V O
authors.initials: VO
authors.lastname: Lyons
authors.forename: S L
authors.initials: SL
authors.lastname: Henry
authors.forename: M
authors.initials: M
authors.lastname: Faghiri
authors.forename: D
authors.initials: D
authors.lastname: Seligson
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D008768:Methylmethacrylates; D008855:Microscopy, Electron, Scanning; D019736:Prostheses and Implants; D011817:Rabbits; D013211:Staphylococcus aureus / Q000502:physiology* / Q000648:ultrastructure; D014031:Tobramycin / Q000008:administration & dosage*; D014946:Wound Infection / Q000382:microbiology*
chemical_list: D008768:Methylmethacrylates; D014031:Tobramycin