Does ispaghula husk stimulate the entire colon in diverticular disease?
The effect of ispaghula husk on colonic motility of the right and left side was examined in 10 patients with left sided diverticular disease using an untethered pressure sensitive radiotelemetry capsule. After treatment, ispaghula husk reduced mouth to rectum transit by a median of 8.8 hours and the time to midtransverse colon by five hours. In the right colon there was an increase in the median percentage activity of 7% and the median number of pressure waves greater than 5 mm Hg/hour rose by 35.3. Motility changes in the left colon were less pronounced. Five of the seven patients with abdominal pain and six of the nine patients with altered bowel habit responded to treatment. These results suggest that it is ispaghula husk's action on the right unaffected colon which alleviates the symptoms of left sided diverticular disease.
Thorburn
H A
HA
University Department of Surgery, Glasgow Royal Infirmary.
Carter
K B
KB
Goldberg
J A
JA
Finlay
I G
IG
D000368:Aged; D001639:Bicarbonates / Q000627:therapeutic use*; D002951:Citrates / Q000627:therapeutic use*; D019343:Citric Acid; D003106:Colon / Q000187:drug effects* / Q000503:physiopathology; D004241:Diverticulum, Colon / Q000178:diet therapy / Q000188:drug therapy* / Q000503:physiopathology; D004338:Drug Combinations; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000627:therapeutic use*; D017693:Sodium Bicarbonate
D001639:Bicarbonates; D002951:Citrates; D004338:Drug Combinations; D010936:Plant Extracts; D019343:Citric Acid; C018299:citric acid, ispaghula husk, sodium bicarbonate drug combination; D017693:Sodium Bicarbonate