Amniotic fluid and umbilical artery levels of sex hormones and prostaglandins in human cocaine users.
Biochemical evaluation of amniotic fluid contents is often used to monitor fetal secretory and excretory functions. To determine whether cocaine use during pregnancy affects fetal endocrine secretions, amniotic fluid and umbilical artery samples were collected at term, and selected gonadal hormones and prostaglandins were assayed. Gestational age, birth weights, and placental weights were recorded. The data showed that birth weights were significantly decreased (P less than 0.001) in cocaine users, but gestational age and placental weights were unaffected. Amniotic fluid levels of androstenedione and testosterone were decreased (P less than 0.05) in males born to cocaine users; females were not affected. Prostaglandins (PGF2 alpha and PGE2) were significantly increased (P less than 0.01) in cocaine users. In the umbilical artery, follicle-stimulating hormone was increased (P less than 0.01) in males and females, while luteinizing hormone was increased (P less than 0.01) only in males. We conclude that cocaine passes through the placenta and affects the fetal testes-hypophyseal endocrine system.
Ahluwalia
B S
BS
Howard University, College of Medicine, Department of Obstetrics & Gynecology, Washington, D.C.
Clark
J F
JF
Westney
L S
LS
Smith
D M
DM
James
M
M
Rajguru
S
S
D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D001724:Birth Weight / Q000187:drug effects; D003042:Cocaine / Q000009:adverse effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D005865:Gestational Age; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology; D010920:Placenta / Q000187:drug effects; D011247:Pregnancy; D011453:Prostaglandins / Q000097:blood / Q000378:metabolism*; D011863:Radioimmunoassay; D012727:Sex Characteristics; D014469:Umbilical Arteries / Q000378:metabolism*
D012739:Gonadal Steroid Hormones; D011453:Prostaglandins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003042:Cocaine