title: Subconjunctival injection of 5-fluorouracil following trabeculectomy for congenital and infantile glaucoma.
abstract: Trabeculectomy and subsequent subconjunctival injections of 5-fluorouracil (5-FU) were performed in four eyes (two children) with congenital glaucoma. Each of these eyes had previously undergone either goniotomy, trabeculotomy, or both; these procedures, however, had failed to control intraocular pressure (IOP) and progressive optic nerve damage. Sixteen and a half months (+/- 1.5 months) after the trabeculectomy and 5-FU treatments, the IOP in these eyes was in the low teens and there was no evidence of further optic-nerve or visual-field deterioration. Although trabeculectomy has been shown to be unsuccessful in managing congenital glaucoma, when it is done with the adjunct of subconjunctival injections of 5-FU, it may be advisable in these cases after previous surgery has failed.
authors.affiliation: Department of Ophthalmology, Kaplan Hospital, Rehovot, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Zalish
authors.forename: H
authors.initials: H
authors.lastname: Leiba
authors.forename: M
authors.initials: M
authors.lastname: Oliver
mesh_terms: D002648:Child; D003228:Conjunctiva; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005901:Glaucoma / Q000151:congenital* / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D008297:Male; D012086:Reoperation; D014130:Trabeculectomy; D014792:Visual Acuity
chemical_list: D005472:Fluorouracil