Nephrotoxic potential of N-(3,5-dichloro-4-hydroxyphenyl)succinimide and N-(3,5-dichloro-4-hydroxyphenyl)succinamic acid in Fischer-344 rats.
The ultimate nephrotoxicant species following administration of the agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) has yet to be determined. The purpose of this study was to examine the nephrotoxic potential of two potential metabolites of NDPS, N-(3,5-dichloro-4-hydroxyphenyl)-succinimide (NDHPS) and N-(3,5-dichloro-4-hydroxyphenyl)succinamic acid (NDHPSA). Male Fischer-344 rats (4 rats/group) were administered a single intraperitoneal injection of NDHPS or NDHPSA (0.2 or 0.4 mmol/kg) or vehicle and renal function was monitored at 24 and 48 h. Neither compound induced marked changes in renal function or morphology. These results suggest that NDHPS and NDHPSA do not contribute significantly to NDPS-induced nephrotoxicity.
Harvison
P J
PJ
Department of Pharmacology and Toxicology, Philadelphia College of Pharmacy and Science, PA 19104-4495.
Griffin
R J
RJ
Teets
V J
VJ
Nicoll
D W
DW
Brown
P I
PI
Rankin
G O
GO
D000818:Animals; D005659:Fungicides, Industrial / Q000378:metabolism / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship; D013386:Succinates / Q000378:metabolism / Q000633:toxicity*; D013388:Succinimides / Q000378:metabolism / Q000633:toxicity*
D005659:Fungicides, Industrial; D013386:Succinates; D013388:Succinimides; C074185:N-(3,5-dichloro-4-hydroxyphenyl)succinimide; C074186:N-(3,5-dichloro-4-hydroxyphenyl)succinamic acid; C007352:N-(3,5-dichlorophenyl)succinimide