[Experimental chemotherapy of peritoneal carcinomatosis of colonic origin in rats].
Animal models are useful in the evaluation of adjuvant or palliative treatment modalities of human colonic adenocarcinoma. In the present paper, the efficacy of 22 usual chemotherapeutic agents was evaluated in a model of peritoneal carcinomatosis of colonic origin in the BD IX rat. Mitomycin, cisplatine, carboplatine, cyclophosphamide, ifosfamide, and thiotepa were very effective agents on microscopic carcinomatosis (treatment given 3 days after an intraperitoneal inoculation of 1 x 10(6) DHD/K12/PROb cells). Intravenous administration was as effective as the intraperitoneal route, except for anthracyclines and 5-fluorouracil. Rats treated at early stages by thiotepa or cisplatin survived up to 4 months after cell injection and did not display tumor at autopsy. Administered late (15 days after cell injection), none of the drugs were able to cure the rats with carcinomatosis.
Chauffert
B
B
Groupe de Recherche sur les Cancers Digestifs Humains et Expérimentaux, INSERM U 252, Faculté de Médecine, Dijon.
Dimanche-Boitrel
M T
MT
Genne
P
P
Petit
J M
JM
Onier
N
N
Jeannin
J F
JF
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor; D005260:Female; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D051381:Rats; D013852:Thiotepa / Q000008:administration & dosage / Q000627:therapeutic use
D000970:Antineoplastic Agents; D016685:Mitomycin; D003520:Cyclophosphamide; D013852:Thiotepa; D002945:Cisplatin; D007069:Ifosfamide
Chimiothérapie expérimentale d'une carcinomatose péritonéale d'origine colique chez le rat.