Trisomy 2 in three cases of canine haemangiopericytoma.
Two female (12 and 14 years old) and one male dog (10 years old) developed haemangiopericytomas. Three copies of chromosome 2 were present in the tumours of all three dogs. Additional alterations were an interstitially deleted chromosome 1, centric fusions 3/34 and 8/15, isochromosome 32 and two unidentified marker chromosomes (M1, M2) in one bitch. In the other bitch, the additional alterations were trisomy 37, centric fusions 8/38 and 30/31, and a derivative chromosome 13 (der13). In the male dog, tandem fusion 2/19 was present in addition to two structurally normal chromosomes 2.
Mayr
B
B
Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.
Furtmueller
G
G
Schleger
W
W
Reifinger
M
M
D000818:Animals; D002871:Chromosome Banding / Q000662:veterinary; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D006393:Hemangiopericytoma / Q000235:genetics / Q000662:veterinary*; D006614:Hindlimb; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000662:veterinary*; D014314:Trisomy