New cholesterol biosynthesis inhibitors MC-031 (O-demethylchlorothricin), -032 (O-demethylhydroxychlorothricin), -033 and -034.
In the course of our screening for microbial compounds which possessed inhibitory activities against biosynthesis of cholesterol from mevalonate, we isolated four new compounds from the cultural broth of Streptomyces sp. A7361. They are structurally related to, but distinct from chlorothricin.
Kawashima
A
A
Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Nakamura
Y
Y
Ohta
Y
Y
Akama
T
T
Yamagishi
M
M
Hanada
K
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D018942:Macrolides; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D018942:Macrolides; C073936:MC 033; C073937:MC 034; C073935:O-demethylhydroxychlorothricin; C073934:O-demethylchlorothricin