title: Two cases of adrenal myelolipoma.
abstract: We report myelolipoma found in two patients, of whom one had hormonal abnormalities related to adrenal function. The first patient was a 36-year-old woman, who was found incidentally to have a left adrenal tumor by CT scan during admission for treatment of Guillain-Barré syndrome. Obesity, hirsutism and osteoporosis were also evident, and the patient was forwarded for additional endocrine function analysis, which revealed elevation of serum cortisol, urine 17-OHCS and 17-KS, and a decreased level of ACTH. These abnormalities returned to normal after excision of the tumor. Pathologically, the tumor was composed of mature fat cells and hematopoietic components, and was diagnosed as myelolipoma. The second patient was a 63-year-old woman, who was receiving follow-up care for hyperthyroidism. A right adrenal tumor was noted incidentally in a routine examination by CT scan. Endocrinologically, she was found to have no abnormalities of adrenal function. The tumor was excised, and diagnosed pathologically as myelolipoma, being composed of mature fat cells and hematopoietic components. Generally, although most myelolipomas have no endocrine function, our first patient showed features of Cushing's syndrome. Thus it is suggested that an interrelationship may exist between myelolipoma and endocrinological alteration.
authors.affiliation: Department of Pathology, Jikei University, School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Asano
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Hori
authors.forename: S
authors.initials: S
authors.lastname: Wakui
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: A
authors.initials: A
authors.lastname: Akiyama
authors.forename: M
authors.initials: M
authors.lastname: Furusato
authors.forename: S
authors.initials: S
authors.lastname: Aizawa
mesh_terms: D000304:Adrenal Cortex Function Tests; D000310:Adrenal Gland Neoplasms / Q000473:pathology* / Q000601:surgery; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006888:Hydroxycholesterols / Q000652:urine; D008067:Lipoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D006888:Hydroxycholesterols; D006854:Hydrocortisone