[Evaluating biological tolerance of PMMA, heparin-modified PMMA and hydrogel intraocular lenses using slit lamp microscopy].
In order to find a difference in the biocompatibility of different IOL-materials we examined the lens-surface of poly(methylmetacrylate)-(PMMA-), heparin surface-modified PMMA-(HSM-PMMA-) and hydrogel-IOLs in a prospective study by specular microscopy. Documentation consisted of cellular reaction, precipitates on the lens-surface and irregularities of the IOL-material. Early postoperative on HSM-PMMA and hydrogel-IOLs there were fewer fibroblast-like cells as compared to PMMA-IOLs. In the later postoperative period foreign body giant cells were seen on PMMA-IOLs in 26.6%, on HSM-PMMA and hydrogel-IOLs in less than 10% of the cases. In cases with increased postoperative inflammation or contact between uveal tissue and lens-surface we found more cells and in a higher percentage. Concerning precipitates on the surface and material irregularities we also found lens-specific differences. Clinical results were satisfactory for all lens-types.
Amon
M
M
Universitäts-Augenklinik, Wien.
Menapace
R
R
D000368:Aged; D005347:Fibroblasts / Q000473:pathology; D005549:Foreign-Body Reaction / Q000473:pathology*; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D006493:Heparin; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007910:Lenses, Intraocular; D008422:Materials Testing; D008768:Methylmethacrylates; D008853:Microscopy; D011092:Polyethylene Glycols; D011183:Postoperative Complications / Q000473:pathology*; D013499:Surface Properties
D008768:Methylmethacrylates; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D006493:Heparin
Beurteilung der biologischen Verträglichkeit von PMMA-, heparinmodifizierten PMMA- und Hydrogel-Intraokularlinsen mit Hilfe der Spiegelmikroskopie.