Malignant hyperpyrexia: a rare cause of postoperative death.
A middle aged man developed very high fever, status epilepticus, and terminal acute renal failure with myoglobinuria after surgery. A post mortem examination showed widespread muscle necrosis with hypercontraction bands. Muscle enzyme studies and electron microscopic examination disclosed central core disease, a condition closely related to malignant hyperpyrexia. This condition is a genetically inherited disorder which can be triggered by certain volatile anaesthetic agents or Suxamethonium. In this patient the condition may have been triggered by either the Isoflurane or the postoperative status epilepticus.
Prescott
R J
RJ
Department of Histopathology, Christie Hospital and Holt Radium Institute, Withington, Manchester.
Roberts
S P
SP
Williams
G
G
D006801:Humans; D007530:Isoflurane / Q000009:adverse effects; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology / Q000473:pathology*; D008875:Middle Aged; D009135:Muscular Diseases / Q000473:pathology*; D009336:Necrosis; D011183:Postoperative Complications / Q000473:pathology*; D013226:Status Epilepticus / Q000150:complications
D007530:Isoflurane