B-raf and a B-raf pseudogene are located on 7q in man.
The B-raf gene was localized to human chromosome region 7p11-7qter by Southern blot analysis of its segregation in a panel of rodent-human hybrids, using a B-raf cDNA clone. Chromosomal in situ hybridization refined the localization to 7q33-36. Analysis of genomic B-raf clones identified a B-raf pseudogene in addition to the active gene. Based on the chromosomal mapping data we conclude that the pseudogene is located near the active gene.
Sithanandam
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G
Biological Carcinogenesis and Development Program, PRI/Dyncorp, Frederick Cancer Research and Development Center, Maryland 21702-1201.
Druck
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T
Cannizzaro
L A
LA
Leuzzi
G
G
Huebner
K
K
Rapp
U R
UR
D001483:Base Sequence; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D011494:Protein Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019908:Proto-Oncogene Proteins c-raf; D011519:Proto-Oncogenes; D011544:Pseudogenes; D015183:Restriction Mapping
D011518:Proto-Oncogene Proteins; D011494:Protein Kinases; D019908:Proto-Oncogene Proteins c-raf