title: Bone marrow granulomas in acute myeloid leukaemia following interleukin 2 and lymphokine-activated killer cells.
abstract: Granulomas are thought to represent an immune reaction to antigenic stimulation. Bone marrow granulomas are uncommon, but in the following case report we show their transient appearance after interleukin 2 (IL-2) and autologous lymphokine-activated killer cell therapy. This is a previously unreported association, and may implicate IL-2 in the pathogenesis of granulomas.
authors.affiliation: Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: D V
authors.initials: DV
authors.lastname: O'Brien
authors.forename: A P
authors.initials: AP
authors.lastname: Boon
authors.forename: B J
authors.initials: BJ
authors.lastname: Boughton
mesh_terms: D000328:Adult; D001855:Bone Marrow Diseases / Q000209:etiology*; D006099:Granuloma / Q000209:etiology*; D006801:Humans; D007376:Interleukin-2 / Q000009:adverse effects* / Q000627:therapeutic use; D015979:Killer Cells, Lymphokine-Activated; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy*; D008297:Male
chemical_list: D007376:Interleukin-2