[Short-term therapy with high dosage omeprazole and amoxicillin for Helicobacter pylori eradication. A pilot study].
In an open study, 50 patients with Helicobacter pylori-associated ulcer disease or severe functional dyspepsia were treated over one week with 2 x 40 mg omeprazole in the morning and evening preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. Fourty-seven patients (ulcer disease: n = 40, functional dyspepsia: n = 7) completed the study without contravening the protocol. The proportion of Helicobacter pylori eradication four weeks after cessation of study medication was 61.7% (29/47 patients) as judged from negative biopsy urease test, specific culture and histology after modified Giemsa staining. Three patients experienced side effects (stomatitis, self-limiting diarrhea, allergic exanthema).
Labenz
J
J
Medizinische Klinik, Universität Essen.
Gyenes
E
E
Rühl
G H
GH
Börsch
G
G
D000658:Amoxicillin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D009853:Omeprazole / Q000008:administration & dosage*; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000382:microbiology; D010865:Pilot Projects
D000658:Amoxicillin; D009853:Omeprazole
Kurzzeittherapie mit hochdosiertem Omeprazol und Amoxicillin zur Helicobacter-pylori-Eradikation. Eine Pilotstudie.