Effects of angiotensin-converting enzyme inhibitors on urinary excretions: interactions with diuretics.
The excretions of urinary sodium, potassium, magnesium, urate, and water after dosing with diuretics or the angiotensin-converting enzyme inhibitor perindopril are reported, as well as the results of other recent studies. Perindopril in low dose had no significant effect on any of these 24-hour urinary excretions and in high dose, in contrast to captopril and enalapril, does not increase magnesium loss. These effects were studied in healthy volunteers, which may not reflect urinary excretions in hypertensive patients.
Leary
W P
WP
Department of Clinical Pharmacology, University of Natal, Durban, South Africa.
Reyes
A J
AJ
Van der Byl
K
K
D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D004347:Drug Interactions; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008274:Magnesium / Q000652:urine; D020913:Perindopril; D012016:Reference Values; D012964:Sodium / Q000652:urine; D014527:Uric Acid / Q000652:urine; D014556:Urine / Q000737:chemistry*
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D014527:Uric Acid; D005665:Furosemide; D012964:Sodium; D008274:Magnesium; D020913:Perindopril