A putative role of hypercholesterolemia in progressive glomerular injury.
Recently, much experimental evidence has accumulated contending that hypercholesterolemia is an aggravating factor in the progression of initial glomerular injury to glomerulosclerosis. Many of the features of progressive glomerular disease share biological properties with those of atherosclerosis, and data suggesting a noxious role for oxidized low-density lipoprotein in the glomerulosclerosis process are emerging. This review discusses these issues and examines the pathobiology of cholesterol-induced glomerular injury.
Diamond
J R
JR
Division of Nephrology, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033.
Karnovsky
M J
MJ
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood; D008264:Macrophages / Q000502:physiology; D009404:Nephrotic Syndrome / Q000097:blood*; D012307:Risk Factors