[Experimental histological study of the local toxicity of intra-tubal injections of methotrexate].
The injection of methotrexate is an alternative to laparoscopic surgical treatment of unruptured ectopic pregnancy. An experimental trial on rabbits was designed to evaluate this new approach. In situ injection of methotrexate does not cause either real tubal epithelial impairment, nor an adverse effect on treated rabbits' fertility. However, sub-peritoneal injections of methotrexate are responsible for a typical histological lesion. These results are discussed emphasising the importance of the way the administration is carried out.
Lecuru
F
F
Clinique Universitaire de Gynécologie-Obstétrique et Pathologie de la Reproduction, Pavillon Paul-Gellé, Roubaix.
Buchet-Bouverne
B
B
Querleu
D
D
Bethouart
M
M
Crépin
G
G
Vasquez
G
G
D000818:Animals; D001706:Biopsy; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D007247:Infertility, Female / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D007249:Inflammation; D007267:Injections; D007279:Injections, Subcutaneous; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D010532:Peritoneal Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*; D011817:Rabbits
D008727:Methotrexate
Etude histologique expérimentale de la toxicité locale de l'injection intratubaire de méthotrexate.