title: Lack of activity of amphotericin B in systemic murine fusarial infection.
abstract: Systemic fusarial infections have emerged as a significant cause of mortality in cancer patients. Yet, little is known about the management of these infections. The in vivo antifungal activity of amphotericin B in CF1 mice with disseminated fusarial infections was studied. Two pathogenic strains of Fusarium solani were used. Intraperitoneal administration of amphotericin B in daily doses of 0.5, 1, and 2 mg/kg for less than or equal to 10 days did not prolong survival of treated animals. Clearance of F. solani from kidneys was similar in mice treated with 1 mg/kg per day of amphotericin B and in untreated animals. These results are in agreement with the known in vitro and in vivo resistance of Fusarium species to amphotericin B.
authors.affiliation: Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030.
authors.forename: E J
authors.initials: EJ
authors.lastname: Anaissie
authors.forename: R
authors.initials: R
authors.lastname: Hachem
authors.forename: C
authors.initials: C
authors.lastname: Legrand
authors.forename: P
authors.initials: P
authors.lastname: Legenne
authors.forename: P
authors.initials: P
authors.lastname: Nelson
authors.forename: G P
authors.initials: GP
authors.lastname: Bodey
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D004195:Disease Models, Animal; D004361:Drug Tolerance; D005670:Fusarium / Q000187:drug effects*; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy*
chemical_list: D000666:Amphotericin B