Platelet-derived growth factor in Dupuytren's disease.
This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.
Badalamente
M A
MA
Department of Orthopaedics, School of Medicine, State University of New York, Stony Brook 11794-8181.
Hurst
L C
LC
Grandia
S K
SK
Sampson
S P
SP
D000328:Adult; D000368:Aged; D002455:Cell Division; D004387:Dupuytren Contracture / Q000378:metabolism / Q000473:pathology*; D005205:Fascia / Q000737:chemistry / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000737:chemistry / Q000473:pathology; D006225:Hand; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000032:analysis*
D010982:Platelet-Derived Growth Factor