[The dynamics of [3H]-cholesterol incorporation into the liver and aortic tissue of guinea pigs on long-term ethanol administration].
The effect of ethanol administration to guinea pigs (4 g/kg, per os) on the dynamics of [3H]-cholesterol incorporation into the liver and aorta tissues was studied for 3 months. It has been discovered that specific radioactivity of the control animals linearly increased during 24 hours in the blood serum. Ethanol reduced it as compared with the control only 0.5 h after a label has been introduced. Cholesterol renovation in the liver remained unchanged under the prolonged effect of ethanol. In the aorta the ethanol effect was characterized by a decrease of [3H]-cholesterol specific radioactivity 0.5 h after its administration. However, in this case the ratio of aorta/blood serum radioactivity increased. A day after the labelled cholesterol administration to alcoholized animals the radioactivity calculated per 1 mg of cholesterol and per unit of tissue weight and referred to the blood serum radioactivity was lower as compared to the control level.
Bozhko
G Kh
GKh
Chursina
V S
VS
Voloshin
P V
PV
D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D006168:Guinea Pigs; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D000431:Ethanol; D002784:Cholesterol
Dinamika vkliucheniia [3H]-kholesterina v tkani pecheni i aorty morskikh svinok pri dlitel'nom vvedeniia étanola.