Serum gastrin concentrations in colorectal cancer patients.
Fasting serum gastrin concentrations were shown to be elevated in colorectal cancer patients compared with controls (P = 0.0037), which was mainly accounted for by a subgroup of patients who had significantly elevated levels. In cancer patients there was no difference in gastrin concentrations in blood taken from a tumour-draining mesenteric vein and from a peripheral vein at the time of colonic resection. Serum gastrin concentrations were significantly lower after apparently curative resection for colorectal cancer (P = 0.028), suggesting that the elevated serum gastrin seen in these patients may be due, at least in part, to secretion of gastrin by the tumour.
Charnley
R M
RM
Department of Surgery, University Hospital, Nottingham.
Thomas
W M
WM
Stanley
J
J
Morris
D L
DL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D005215:Fasting / Q000097:blood; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008642:Mesenteric Veins; D008875:Middle Aged; D011184:Postoperative Period
D005755:Gastrins