Dose-responsive effect of radiotherapy on the tumor uptake of L-[methyl-11C]methionine; feasibility for monitoring recurrence of tumor.
The L-[methyl-11C]methionine [( 11C]Met) uptake by rat AH109A tumor was decreased irradiation-dose dependently from the control to 5, 10 and 20 Gy. After 10 Gy irradiation, the [11C]Met uptake decreased earlier than the tumor volume reduction, and later, it significantly increased earlier than the recurrent growth. Double tracer autoradiography with [14C]Met and 4-[18F]fluoroantipyrine showed a decrease in the [14C]Met tumor uptake without change of blood flow after irradiation. The [11C]Met uptake representing amino acid metabolism is a sensitive indicator for monitoring radiotherapeutic effect on tumor.
Kubota
K
K
Department of Radiology, Tohoku University, Sendai, Japan.
Ishiwata
K
K
Yamada
S
S
Kubota
R
R
Sato
T
T
Takahashi
J
J
Ito
H
H
Ido
T
T
Tada
M
M
D000818:Animals; D001345:Autoradiography; D004307:Dose-Response Relationship, Radiation; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism* / Q000532:radiotherapy; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives* / Q000378:metabolism; D051381:Rats; D012039:Regional Blood Flow / Q000528:radiation effects
D008715:Methionine; C038344:methionine methyl ester