title: Galacardins A and B, new glycopeptide antibiotics.
abstract: A strain of actinomycetes identified as Saccharothrix sp. SANK 64289 was found to produce new antibiotics, galacardins A and B. Their physico-chemical properties showed that they were new members of glycopeptide antibiotics. They were structurally related to beta-avoparcin but differed from it only in sugar composition. Though beta-avoparcin does not contain galactose, galacardins A and B did contain two and one moles of galactose, respectively. They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus infection in mice.
authors.affiliation: Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: R
authors.initials: R
authors.lastname: Enokita
authors.forename: Y
authors.initials: Y
authors.lastname: Sakaida
authors.forename: H
authors.initials: H
authors.lastname: Haruyama
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Katayama
authors.forename: M
authors.initials: M
authors.lastname: Inukai
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D006020:Glycopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C074357:galacardin B; C074356:galacardin A