title: [Involvement of PAF (Platelet-Activating Factor) in chloroquine-induced retinopathy].
abstract: Chloroquine retinopathy is a severe toxic retinal impairment which may result in loss of vision by alterations of the pigmentary epithelium and photoreceptors. Currently, there is no specific treatment for this retinopathy. In order to test the possible involvement of Platelet-Activating Factor (PAF) in chloroquine-induced retinopathy and the use of PAF antagonists for prevention of this condition, we have examined the effect of these substances on the electroretinogram (ERG) of isolated rat retina. When retinas from normal rats were perfused with chloroquine (10(-6) M), a marked and rapid decrease in ERG b-wave amplitude was observed. In contrast, chloroquine had no effect on the ERG of retina isolated from animals pretreated with the PAF antagonist, BN 50730 (30 mg/kg/day i.p., 5 days). The results obtained indicate that (i) chloroquine is a toxic drug for retinal function, (ii) PAF plays a key role in chloroquine retinopathy and (iii) PAF antagonists may constitute valuable agents for the treatment of this retinal impairment.
authors.affiliation: Laboratoire de Biophysique, I.N.S.E.R.M., n. U71, Facultés de Médecine et de Pharmacie, Clermont-Ferrand.
authors.forename: G
authors.initials: G
authors.lastname: Meyniel
authors.forename: M
authors.initials: M
authors.lastname: Doly
authors.forename: M
authors.initials: M
authors.lastname: Millerin
authors.forename: P
authors.initials: P
authors.lastname: Braquet
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000009:adverse effects*; D004596:Electroretinography; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000502:physiology*; D051381:Rats; D012160:Retina / Q000187:drug effects; D012164:Retinal Diseases / Q000139:chemically induced* / Q000503:physiopathology* / Q000517:prevention & control
chemical_list: D010972:Platelet Activating Factor; D002738:Chloroquine
vernacular_title: Implication du PAF (Platelet-Activating Factor) dans la rétinopathie à la chloroquine.