Plasma free fatty acids and serum insulin in subjects feeding at 12-hour intervals; effects of methionyl growth hormone and of acipimox, an inhibitor of lipolysis.
In normal men, plasma free fatty acids (FFA) are influenced by feeding and by fasting; in addition, iv infusions of methionyl growth hormone (met-GH), so far performed during morning hours, induce an FFA rise that can be blocked by acipimox (ACX), a nicotinic acid analogue. The aims of the present study were to evaluate, in the absence of food interferences, the following aspects: i) Fasting FFA, glycerol, and insulin (IRI) in the morning and in the evening, and their response to met-GH ii) The effect of ACX and of a sustained release ACX formulation (ACX-SR) on fasting and met-GH induced lipolysis and on IRI levels. In a double blind study, 6 normal men received 50% cal at 09:30 h and 50% at 21:30 h; during placebo administrations FFA, glycerol, and IRI levels were lower at 06:30 h than at 18:30 h, and an iv met-GH infusion (160 ng/kg/min lasting 180 min) had a similar effect on FFA and on glycerol at 06:30 h and at 18:30 h. ACX-SR, administered at 21:30 h and 09:30 h, lowered FFA and glycerol in the morning as well as in the evening, and prevented met-GH induced lipolysis in the morning, but not in the evening.(ABSTRACT TRUNCATED AT 250 WORDS)
Pontiroli
A E
AE
Istituto San Raffaele, Cattedra di Clinica Medica, Università di Milano, Italy.
Lanzi
R
R
Monzani
M
M
Musatti
L
L
Guglielmone
C
C
Pozza
G
G
D002940:Circadian Rhythm; D004311:Double-Blind Method; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005502:Food; D005990:Glycerol / Q000097:blood*; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D019382:Human Growth Hormone; D006801:Humans; D007328:Insulin / Q000097:blood*; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D011719:Pyrazines / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D006728:Hormones; D007328:Insulin; D011719:Pyrazines; D019382:Human Growth Hormone; D013006:Growth Hormone; C027696:acipimox; D005990:Glycerol