title: Glucose-induced modulation of nutrient influx in Schistosoma mansoni.
abstract: The tegumental influx of adenine, adenosine, arginine, choline, histidine, and lysine has been measured in mated and separated male and female Schistosoma mansoni 7-10 wk postinfection. Tissue uptake indices were measured after a brief rinse in either 5 mM glucose or glucose-free saline. Data indicate that schistosomes respond rapidly to this 2-3-sec exposure to glucose-free medium, and lowered uptake rates are observed. Similar studies, measuring cytosine and lysine uptake in Schistosoma japonicum indicate that, in this species also, reduced nutrient influx is seen after a transient exposure to glucose-free medium. It is proposed that these metabolites are not taken up by active transport processes, but rather the effect observed is the consequence of a rapid change in glucose metabolism.
authors.affiliation: Comprehensive Epilepsy Program, Veterans Administration West Los Angeles Medical Center, California.
authors.forename: E M
authors.initials: EM
authors.lastname: Cornford
authors.forename: A M
authors.initials: AM
authors.lastname: Fitzpatrick
mesh_terms: D000225:Adenine / Q000378:metabolism; D000241:Adenosine / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000378:metabolism; D001692:Biological Transport; D002794:Choline / Q000378:metabolism; D003596:Cytosine / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006639:Histidine / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D008297:Male; D012549:Schistosoma japonicum / Q000378:metabolism; D012550:Schistosoma mansoni / Q000378:metabolism*
chemical_list: D006639:Histidine; D003596:Cytosine; D001120:Arginine; D005947:Glucose; D000225:Adenine; D008239:Lysine; D000241:Adenosine; D002794:Choline