title: Exclusive breast-feeding and weaning: effect on serum cholesterol and lipoprotein concentrations in infants during the first year of life.
abstract: The total serum cholesterol concentration of infants was investigated at birth (n = 193) and at the ages of 2 (n = 192), 4 (n = 192), 6 (n = 190), 9 (n = 188), and 12 months (n = 196). Concentrations of cholesterol--very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), high-density lipoprotein-2 (HDL2), HDL3--and apoprotein B were analyzed in 36 infants at 2, 6, 9, and 12 months of age. Serum cholesterol concentration rose significantly more slowly in the weaned infants compared with exclusively breast-fed infants. The mean difference in total serum cholesterol value between the exclusively breast-fed and weaned infants was largest at ages 2 (0.9 mmol/L, P less than .001), 4 (0.6 mmol/L, P less than .01), and 6 months (0.5 mmol/L, P less than .01). The LDL cholesterol concentration was lower in weaned infants compared with exclusively breast-fed infants at age 2 and 6 months; the mean difference in LDL cholesterol value was 0.9 mmol/L at age 2 months (P less than .001) and 0.7 mmol/L at age 6 months (P less than .025). Also, the apoprotein B concentration was lower in weaned infants; the mean difference was 24 mg/dL at age 2 months (P less than .01) and 30 mg/dL at age 6 months (P less than .05). The apoprotein B-LDL cholesterol ratio was stable and similar in both feeding groups through the year. The HDL2 cholesterol concentration was lower in the formula-fed than in breast-fed infants at 2 months of age while the VLDL and HDL3 cholesterol concentrations were independent of the diet.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Children's Hospital, University of Helsinki, Finland.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kallio
authors.forename: L
authors.initials: L
authors.lastname: Salmenperä
authors.forename: M A
authors.initials: MA
authors.lastname: Siimes
authors.forename: J
authors.initials: J
authors.lastname: Perheentupa
authors.forename: T A
authors.initials: TA
authors.lastname: Miettinen
mesh_terms: D001055:Apolipoproteins B / Q000097:blood; D001942:Breast Feeding; D002784:Cholesterol / Q000032:analysis / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D005312:Fetal Blood / Q000737:chemistry; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000032:analysis; D007231:Infant, Newborn; D008074:Lipoproteins / Q000032:analysis / Q000097:blood*; D008137:Longitudinal Studies; D008895:Milk, Human / Q000737:chemistry; D014280:Triglycerides / Q000032:analysis / Q000097:blood; D014886:Weaning
chemical_list: D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D005231:Fatty Acids, Unsaturated; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol