Familial occurrence of pruritic urticarial papules and plaques of pregnancy.
BACKGROUND
The occurrence of pruritic urticarial papules and plaques of pregnancy (PUPPP) was noted in four women with unusual family relationships.


OBJECTIVE
The purpose of the study was to document the occurrence of PUPPP in these families and to make observations on their possible relevance.


METHODS
Case reports of the four patients are detailed. Histologic and HLA studies are recorded.


RESULTS
In both families, sisters were married to brothers. A common paternal influence is suggested.


CONCLUSIONS
We postulate that PUPPP may be a maternal response to a circulating paternal factor for which tolerance develops in subsequent pregnancies.
Weiss
R
R
University of the Witwatersrand Medical School, Johannesburg, South Africa.
Hull
P
P
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D004200:Diseases in Twins / Q000235:genetics; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D010375:Pedigree; D011247:Pregnancy / Q000235:genetics; D011248:Pregnancy Complications / Q000473:pathology*; D011537:Pruritus / Q000235:genetics* / Q000473:pathology; D012867:Skin / Q000473:pathology; D014581:Urticaria / Q000235:genetics* / Q000473:pathology
D006680:HLA Antigens