Intracellular free magnesium in lymphocytes from patients with congestive cardiac failure treated with loop diuretics with and without amiloride.
Cellular Mg2+ depletion has been reported in patients on long term diuretic therapy. We therefore measured lymphocyte free Mg2+ concentrations in patients with congestive cardiac failure treated with loop diuretics or a frusemide/amiloride mixture (Frumil) and compared them with control subjects. There was no correlation between lymphocyte free Mg2+ levels and plasma Mg2+ concentrations. Patients treated with loop diuretics did not show lymphocyte intracellular free Mg2+ depletion compared with normal controls, and those on Frumil showed higher intracellular free Mg2+ levels than normal.
Ng
L L
LL
Department of Pharmacology & Therapeutics, Leicester Royal Infirmary.
Garrido
M C
MC
Davies
J E
JE
Brochwicz-Lewinski
M J
MJ
Tan
L B
LB
D000584:Amiloride / Q000627:therapeutic use*; D002034:Bumetanide / Q000627:therapeutic use*; D002413:Cations, Divalent; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008274:Magnesium / Q000097:blood*; D013050:Spectrometry, Fluorescence
D002413:Cations, Divalent; D002034:Bumetanide; D000584:Amiloride; D005665:Furosemide; D008274:Magnesium