The coronary bed and its role in the cardiovascular system: a review and an introductory single-branch model.
To investigate cardiovascular haemodynamics under normal and pathological conditions, a closed-loop model of the cardiovascular system already presented in the literature, has been complemented by a model of the coronary bed. Oxygen available to the myocardium is strictly related to the coronary blood flow; we have developed threshold criteria which correlate cardiac output with the coronary flow. The system utilizes control systems related to the cardiac contractility and frequency, and imitates feedback mechanisms peculiar to the heart. The work exemplifies the autoregulation of events that occur when the equilibrium of the system is disturbed. It is suggested that the heart plays an active role in trying to restore the haemodynamic parameters to their physiological values.
Mantero
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S
Dipartimento di Bioingegneria, Politecnico di Milano, Italy.
Pietrabissa
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R
Fumero
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R
D001783:Blood Flow Velocity; D003326:Coronary Circulation; D003331:Coronary Vessels; D004560:Electricity; D005069:Evaluation Studies as Topic; D005246:Feedback; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction