Antiplasmid activity of phenothiazines, benzo[a]phenothiazines and benz[c]acridines.
Various synthetic derivatives of phenothiazines, benzo[a]phenothiazines and benz[c]acridines were compared for their abilities to induce antiplasmid activity against E. coli F'lac plasmid. Several phenothiazine derivatives were much more potent in antiplasmid activity than benzo[a]phenothiazine- or benz[c]acridine derivatives. Their antiplasmid activity seemed to be enhanced by Cl- or CF3- substitution at 2 C atom, and modified by the side chain length and charge at the L-region of the molecules, as well as by hydrophilicity.
Motohashi
N
N
Department of Medicinal Chemistry, Meiji College of Pharmacy, Tokyo, Japan.
Sakagami
H
H
Kurihara
T
T
Csuri
K
K
Molnar
J
J
D000166:Acridines / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D010640:Phenothiazines / Q000494:pharmacology*; D010957:Plasmids / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000166:Acridines; D010640:Phenothiazines; C032894:benz(a)acridine