Biological response to chopped-carbon-fiber-reinforced peek.
Polymer composites are being recognized as important implant materials for fracture fixation plates. The use of a composite material is dependent upon the mechanical properties of the material and its biocompatibility. The primary objective of this project was to evaluate 30% chopped-carbon-fiber-reinforced poly(etheretherketone) (CFRPEEK) as a potential material for use as a fracture fixation plate. A two-phase study was conducted. The first phase analyzed the short-term biocompatibility of CFRPEEK through rabbit muscle implant testing. CFRPEEK exhibited a nonspecific foreign body tissue reaction similar to the response observed with ultra-high-molecular-weight polyethylene (UHMWPE). In the second phase, four-hole CFRPEEK plates were implanted as internal fixation devices for transverse midshaft femoral osteotomies in beagles. The plates were effective in promoting fracture healing. A nonspecific foreign body reaction was observed to the plates and to particulate debris.
Jockisch
K A
KA
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207.
Brown
S A
SA
Bauer
T W
TW
Merritt
K
K
D000818:Animals; D001577:Benzophenones; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001860:Bone Plates; D002244:Carbon; D004285:Dogs; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology; D005593:Fracture Fixation, Internal; D007659:Ketones / Q000009:adverse effects; D008297:Male; D008422:Materials Testing; D009132:Muscles / Q000601:surgery; D010027:Osteotomy; D011092:Polyethylene Glycols / Q000009:adverse effects; D011108:Polymers; D011817:Rabbits
D001577:Benzophenones; D001672:Biocompatible Materials; D007659:Ketones; D011108:Polymers; C063834:polyetheretherketone; D011092:Polyethylene Glycols; D002244:Carbon