[Study on immune persistency of combined diphtheria-pertussis-tetanus (DPT) triple vaccine].
Immune efficacy and persistency were studied by comparison of two-dose immunization of adsorbed DPT at one and two month interval and two & three dose immunization of unadsorbed DPT during 1970s and 1980s. Serological investigation showed that antibody response to diphtheria, tetanus were elicited in four groups of children after primary immunization, but, the antibody response to pertussis was poor in children immunized with unadsorbed DPT. Three kinds of antibody titres were increased significantly after booster immunization. Antibody persists more than eight years for diphtheria, about five years for tetanus and only three years for pertussis. Comparison of two-dose immunization of adsorbed DPT at two months interval and three dose immunization of unadsorbed DPT showed that antibody response to diphtheria, pertussis and tetanus were satisfied in adsorbed DPT than in unadsorbed one after primary immunization, and there is no difference between primary and booster immunization.
Diao
L
L
Jiangsu Health and Anti-epidemic Station, Nanjing.
D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D013997:Time Factors
D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine