In vitro antiproliferative effects of tricyclic psychopharmaceutical agents and synergism with some resistance modifiers.
Some of the phenothiazines and dibenz[b,f]azepines exert an antiproliferative effect on HEp-2 and rat prolactinoma cells. The same compounds also have effects on different membrane-bound biochemical events, such as H2O2 formation and the peroxide-generated chemiluminescence of polymorphonuclear leukocytes. The superoxide dismutase inhibition by 7,8-dioxochlorpromazine and 6,9-dioxochlorpromazine have some relation to the growth inhibitory action on the growth of HEP-2 and prolactinoma cells in vitro. The antiproliferative effects of phenothiazines were synergized with resistance modifiers like verapamil, omeprazole and tubulozole-C, due to increased drug-influx or decreased drug-efflux and due to possible action on the cytoskeleton.
Molnar
J
J
Institute of Microbiology, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
Tarodi
B
B
Galfi
M
M
Matkovics
B
B
Motohashi
N
N
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004148:Dioxolanes / Q000494:pharmacology; D004351:Drug Resistance; D004357:Drug Synergism; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010640:Phenothiazines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D000970:Antineoplastic Agents; D004148:Dioxolanes; D010640:Phenothiazines; D011619:Psychotropic Drugs; C040422:tubulazole; D014700:Verapamil; D013482:Superoxide Dismutase