title: Suppression of annual testicular development in Indian Palm squirrel, Funambulus pennanti by 8 hr temporal relationship of serotonin and dopamine precursor drugs.
abstract: Daily injections of 5-HTP (5-hydroxytryptophan, serotonin precursor) and L-DOPA (L-Dihydroxyphenylalanine, dopamine precursor) given 8 hour apart inhibited normal testicular growth in seasonally breeding Indian Palm Squirrel, Funambulus pennanti leading to complete gonadal atrophy, which was maintained till the end of the study. HCG administration induced higher degree of gonadal development but, when the two treatments (HCG + 8 hr relationship of 5-HTP and L-DOPA) were given simultaneously no significant difference was observed compared to control. Results indicate that induced suppression of gonadal function in a fashion similar to seasonal regression leading to non-breeding condition is the consequence of specific phase relationship (8 hr) between serotonergic and dopaminergic activities and not due to Serotonin or dopamine alone. This suggestion gets support from the finding that gonadal condition of squirrels receiving only 5-HTP (5-HTP control) or L-DOPA (DOPA control) was not different from control and exhibited normal testicular growth. It also seems that neurotransmitter precursor drugs given 8 hr apart possibly inhibited the activity of neuroendocrine-gonadal axis since this effect was overpowered by stimulatory effect of gonadotrophin. The findings strongly support the hypothesis that specific phase relation of circadian serotonergic and dopaminergic oscillations account for seasonal reproductive conditions.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varanasi, India.
authors.forename: C M
authors.initials: CM
authors.lastname: Chaturvedi
authors.forename: A B
authors.initials: AB
authors.lastname: Singh
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D012589:Sciuridae / Q000254:growth & development*; D013737:Testis / Q000254:growth & development*; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin; D007980:Levodopa; D006916:5-Hydroxytryptophan