title: Intravenous fluid therapy in neurologic injury.
abstract: Cerebral autoregulation and the blood-brain barrier are two important mechanisms that attempt to preserve brain homeostasis. The function of either may be disrupted by injury. When autoregulation is impaired, blood pressure and hematocrit determine cerebral oxygen delivery. Injury to the blood-brain barrier impairs brain volume regulation and may contribute to cerebral edema. The choice of intravenous fluid influences cerebral blood flow, cerebral oxygen delivery, brain metabolism, and brain volume.
authors.affiliation: Department of Anesthesiology, New York, University Medical Center, New York.
authors.forename: K M
authors.initials: KM
authors.lastname: Sutin
authors.forename: K J
authors.initials: KJ
authors.lastname: Ruskin
authors.forename: B S
authors.initials: BS
authors.lastname: Kaufman
mesh_terms: D000818:Animals; D001809:Blood Viscosity; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D001930:Brain Injuries / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D002245:Carbon Dioxide / Q000502:physiology; D002415:Cats; D002560:Cerebrovascular Circulation; D003102:Colloids / Q000494:pharmacology / Q000627:therapeutic use; D000077324:Crystalloid Solutions; D004285:Dogs; D005073:Evoked Potentials, Somatosensory; D005440:Fluid Therapy / Q000379:methods* / Q000592:standards; D006400:Hematocrit; D006438:Hemodilution / Q000592:standards; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D007552:Isotonic Solutions; D009997:Osmotic Pressure; D010100:Oxygen / Q000502:physiology; D010952:Plasma Substitutes / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D012756:Sheep; D012769:Shock / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D002245:Carbon Dioxide; D010100:Oxygen