Genomic organization of the gene and a related pseudogene for a human folate binding protein.
An unprocessed pseudogene which is 90% homologous with the cDNA encoding a folate binding protein in KB cells has been cloned from a human genomic library. This pseudogene contains TGA stop codons, base deletions and substitutions and lacks a 5' region. The size of the exons and the intron-exon sites are almost identical to the organization of the gene encoding this protein which has now been characterized from genomic DNA using the polymerase chain reaction with selected primers to the cDNA.
Sadasivan
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Department of Medicine, State University of New York, Health Science Center, Brooklyn.
Cedeno
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Rothenberg
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SP
D000595:Amino Acid Sequence; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002460:Cell Line; D003001:Cloning, Molecular; D003062:Codon; D005091:Exons; D058973:Folate Receptors, GPI-Anchored; D005796:Genes; D015698:Genomic Library; D006801:Humans; D007438:Introns; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011544:Pseudogenes; D011956:Receptors, Cell Surface
D002352:Carrier Proteins; D003062:Codon; D058973:Folate Receptors, GPI-Anchored; D011956:Receptors, Cell Surface