Measurement of blood-brain barrier permeability using dynamic Gd-DTPA scanning--a comparison of methods.
Two recently published methods of blood-brain barrier permeability measurement using Gd-DTPA scanning are compared by authors representing each group. The physiological models are reconciled. Results from both groups agree. These show that the transfer constant (the permeability surface area product per unit volume of tissue) of the defective blood-brain barrier in multiple sclerosis is in the range 1-12.10(-4) s-1.
Larsson
H B
HB
Danish Research Centre of Magnetic Resonance, Hvidovre Hospital, Denmark.
Tofts
P S
PS
D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000378:metabolism; D003287:Contrast Media; D005682:Gadolinium / Q000097:blood / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008954:Models, Biological; D009942:Organometallic Compounds / Q000097:blood / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000097:blood / Q000493:pharmacokinetics*; D010539:Permeability
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA