title: [HTLV-I retroviral variant in Zaire in patient with chronic neuromyelopathy. Nucleotidic sequence of the envelope gene].
abstract: The oncoretrovirus HTLV-I is the etiological agent of adult T cell leukemia (ATL) and tropical spastic paraparesis/HLTV-I associated myelopathy (TSP/HAM). In contrast to the human lentiretroviruses, HIV-I and HIV-2, the causative agents of AIDS, HTLV-I is genetically very stable. We report here the molecular characterization of the envelope gene of an HTLV-I variant present in a TSP/HAM patient from Zaïre, raising the question of its relevance to disease or the ethnic and/or geographical origin of the patient.
authors.affiliation: Laboratory of Tumor Cell Biology, National Cancer Institute, National Institute of Health, Bethesda.
authors.forename: A
authors.initials: A
authors.lastname: Gessain
authors.forename: E
authors.initials: E
authors.lastname: Boeri
authors.forename: K
authors.initials: K
authors.lastname: Kazadi
authors.forename: B
authors.initials: B
authors.lastname: Garin
authors.forename: J J
authors.initials: JJ
authors.lastname: Salaün
authors.forename: R
authors.initials: R
authors.lastname: Gallo
authors.forename: G
authors.initials: G
authors.lastname: de Thé
authors.forename: G
authors.initials: G
authors.lastname: Franchini
mesh_terms: D001483:Base Sequence; D002908:Chronic Disease; D015023:Democratic Republic of the Congo; D015752:Genes, env / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D015368:Human T-lymphotropic virus 1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000382:microbiology*
vernacular_title: Variant retroviral HTLV-I au Zaïre chez un patient ayant une neuromyélopathie chronique. Séquence nucléotidique du gène d'enveloppe.