title: Radiotherapy of malignant subdiaphragmatic implants in advanced ovarian carcinoma: a new technique.
abstract: We report the development of a new technique using remote afterloading intraoperative radiation therapy to deliver a tumoricidal dose to diaphragmatic tumor implants. A multi-positional lucite applicator was designed based on anatomic studies of the diaphragmatic surface to accommodate a high dose rate iridium source in a series of needles placed 1.5 cm apart. The applicator curvature can vary from planar to full accommodation of the diaphragmatic surface with a constant source to surface distance of 0.5 cm. The applicator has been piloted in three patients with ovarian carcinoma with residual subdiaphragmatic disease found at second look laparotomy, to deliver a dose of 1,500 to 2,000 cGy at 0.5 cm. Tolerance of the diaphragm and hepatic surface has been excellent. There were no postoperative complications and no deterioration in liver function studies. The additional postoperative external beam irradiation directed with the aid of surgically placed clips and gated to respiratory movements permits achievement of a tumoricidal dose while limiting the treated volume and related toxicities.
authors.affiliation: Division of Radiation Oncology, Georgetown University School of Medicine, Washington, D.C. 20007.
authors.forename: M
authors.initials: M
authors.lastname: Pirkowski
authors.forename: R
authors.initials: R
authors.lastname: Holloway
authors.forename: G
authors.initials: G
authors.lastname: Delgado
authors.forename: W
authors.initials: W
authors.lastname: Barnes
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Torrisi
authors.forename: G
authors.initials: G
authors.lastname: Popescu
authors.forename: J
authors.initials: J
authors.lastname: Rodgers
authors.forename: A
authors.initials: A
authors.lastname: Dritschilo
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D003131:Combined Modality Therapy; D003964:Diaphragm; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery
chemical_list: D007496:Iridium Radioisotopes