title: Assessment of portosystemic shunting from superior mesenteric vein by duodenal administration of iodoamphetamine I123.
abstract: Portosystemic shunting (PSS) from the superior mesenteric vein (SMV) was evaluated with the duodenal administration of iodoamphetamine I123 (IMP) in patients with chronic hepatitis and liver cirrhosis. After duodenal intubation, IMP was administered through a tube, and then scintigraphy including the pulmonary and hepatic regions was performed. In all patients, images of the liver and/or lungs were observed within 10 min and became clear with time, due to a good absorption of IMP from the intestine. On the other hand, IMP appears not to be absorbed from the stomach. The portosystemic shunt index was calculated by dividing counts of lungs by counts of liver and lungs. The shunt index (mean +/- SE) was 1.5% +/- 0.8%, 12.6% +/- 3.7% and 28.3% +/- 4.5% in chronic hepatitis, compensated cirrhosis and decompensated cirrhosis, respectively. This index was significantly higher in cirrhosis, especially in decompensated cirrhosis. Therefore, transintestinal portal scintigraphy with IMP could be a useful method for the non-invasive and quantitative evaluation of PSS from the SMV in portal hypertension.
authors.affiliation: Department of Radiology and Nuclear Medicine, Osaka University Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kashiwagi
authors.forename: H
authors.initials: H
authors.lastname: Fukui
authors.forename: T
authors.initials: T
authors.lastname: Kozuka
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Takei
authors.forename: A
authors.initials: A
authors.lastname: Kasahara
authors.forename: S
authors.initials: S
authors.lastname: Kawano
authors.forename: H
authors.initials: H
authors.lastname: Fusamoto
authors.forename: T
authors.initials: T
authors.lastname: Kamada
authors.forename: M
authors.initials: M
authors.lastname: Azuma
mesh_terms: D000662:Amphetamines / Q000008:administration & dosage; D002908:Chronic Disease; D006505:Hepatitis / Q000000981:diagnostic imaging*; D006801:Humans; D007441:Intubation, Gastrointestinal; D007457:Iodine Radioisotopes / Q000008:administration & dosage; D020367:Iofetamine; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D008642:Mesenteric Veins / Q000002:abnormalities* / Q000000981:diagnostic imaging; D011168:Portal System / Q000002:abnormalities* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine