title: Supply-dependent oxygen consumption and mixed venous oxyhemoglobin saturation during isovolemic hemodilution in pigs.
abstract: To assess the responsiveness of mixed venous oximetry under conditions of supply-independent and supply-dependent oxygen consumption, we subjected ten pigs to graded isovolemic hemodilution while measuring cardiopulmonary variables, including oxygen consumption (VO2), oxygen delivery (DO2), and mixed venous oxyhemoglobin saturation (SvO2). Supply-dependent VO2 was reached at an average hemoglobin concentration of 3.9 +/- 0.7 g.dl-1, an SvO2 of 38.2 +/- 8.1 percent, and an oxygen extraction ratio of 0.55 +/- 0.10. The change in SvO2 corresponding to a 100-ml decrease in DO2 was -9.2 +/- 3.7 percent when VO2 was supply-independent and -7.6 +/- 5.2 percent when it was supply-dependent (NS). However, the rate of decline in SvO2 in the supply-dependent range was significantly slower than the rate calculated assuming unchanged VO2 (-32.6 +/- 16.3 percent; p less than 0.01). The results indicate that appearance of supply-dependence of VO2 does not render mixed venous oximetry unresponsive to further deterioration of oxygen supply during isovolemic hemodilution.
authors.affiliation: Department of Anesthesiology, University of South Florida College of Medicine, Tampa.
authors.forename: J
authors.initials: J
authors.lastname: Räsänen
mesh_terms: D000818:Animals; D001810:Blood Volume / Q000502:physiology*; D006321:Heart / Q000502:physiology; D006438:Hemodilution; D008168:Lung / Q000502:physiology; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology*; D010108:Oxyhemoglobins / Q000032:analysis*; D013552:Swine; D014680:Veins
chemical_list: D010108:Oxyhemoglobins; D010100:Oxygen