title: Effects of a vascular graft/natural artery compliance mismatch on pulsatile flow.
abstract: Attempts have been made to correlate small-diameter vascular graft patency with compliance matching between the graft and the host artery. Without knowledge about the mechanisms of failure by compliance mismatch, however, such correlations remain empirical. We have developed a flow system which mimics the flow in peripheral arteries and techniques to model a compliance mismatch in a straight elastic tube, as might occur with vascular repair. Our goal was to investigate one proposed mechanism of graft failure by compliance mismatch, that of a blood flow disturbance. Flow visualization experiments showed that, under pulsatile flow, a compliance mismatch caused trapping of 40 microns microspheres at the wall near the distal or downstream anastomosis. This suggests that the presence of a microscopic flow separation or stagnant zone in vivo may contribute to the intimal hyperplasia and thrombosis seen in failed grafts.
authors.affiliation: Department of Materials Science and Engineering, University of Utah, Salt Lake City 84112.
authors.forename: S F
authors.initials: SF
authors.lastname: Stewart
authors.forename: D J
authors.initials: DJ
authors.lastname: Lyman
mesh_terms: D000054:Acceleration; D000714:Anastomosis, Surgical; D000818:Animals; D001158:Arteries / Q000502:physiology* / Q000601:surgery / Q000637:transplantation*; D001783:Blood Flow Velocity; D001794:Blood Pressure; D004285:Dogs; D004548:Elasticity; D005263:Femoral Artery; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012039:Regional Blood Flow; D013314:Stress, Mechanical; D013927:Thrombosis / Q000503:physiopathology; D014654:Vascular Patency