title: Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB.
abstract: The nucleotide sequence of a 1.6-kb clone containing the gene for outer surface protein A (OspA) of a German strain (GO2) of Borrelia burgdorferi was determined. The deduced amino acid sequence showed a homology of 82% to the OspA molecules from three other B. burgdorferi strains. The best-conserved region was recognized at the 36-amino-terminal amino acids of OspA. OspB could not be identified in the strain investigated, probably because the nucleotide sequence of the ospAB operon prevented expression of the OspB gene.
authors.affiliation: Department of Medical Microbiology, University of Göttingen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Eiffert
authors.forename: A
authors.initials: A
authors.lastname: Ohlenbusch
authors.forename: W
authors.initials: W
authors.lastname: Fehling
authors.forename: H
authors.initials: H
authors.lastname: Lotter
authors.forename: R
authors.initials: R
authors.lastname: Thomssen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D001483:Base Sequence; D015748:Borrelia burgdorferi Group / Q000235:genetics*; D003001:Cloning, Molecular; D008969:Molecular Sequence Data; D009876:Operon; D011817:Rabbits
chemical_list: D001425:Bacterial Outer Membrane Proteins