title: Detection of autoimmunity parameters in the acquired immunodeficiency syndrome (AIDS).
abstract: We have examined various autoimmunity parameters in AIDS with special emphasis on the expression of pemphigus and bullous pemphigoid antibodies. Sera from healthy seropositive individuals without syphilis (CS-, n = 17), seropositive individuals with syphilis (cs+, n = 11), and patients with AIDS (n = 6) were studied and compared with normal controls (n = 30); autoimmunity parameters related to dermatology were evaluated. Indirect immunofluorescence (IIF) for pemphigus and pemphigoid antibodies, antinuclear antibodies (ANA), anti-DNA antibodies, antismooth muscle antibodies (ASMA) antimitochondrial antibodies (AMA), and antithyroid antibodies (ATA) was carried out and findings were graded with a cumulative index (CI) for each patient group. Pemphigus and bullous pemphigoid-like antibodies (IgG, PV + BP) were detected in 33% of the AIDS patients. Statistically increased CI (P less than 0.01) was found in the CS- group compared with the CS+ group and in the AIDS group compared with CS- (P less than 0.01).
authors.affiliation: Department of Dermatology, Athens Hospital for Infectious Diseases, Greece.
authors.forename: K
authors.initials: K
authors.lastname: Kyriakis
authors.forename: A
authors.initials: A
authors.lastname: Tosca
authors.forename: J
authors.initials: J
authors.lastname: Katsantonis
authors.forename: M
authors.initials: M
authors.lastname: Hatzivasiliou
authors.forename: G
authors.initials: G
authors.lastname: Eliopoulos
authors.forename: J
authors.initials: J
authors.lastname: Stratigos
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D010391:Pemphigoid, Bullous / Q000276:immunology; D010392:Pemphigus / Q000276:immunology; D013587:Syphilis / Q000150:complications / Q000276:immunology
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M