Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.
A retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%).
Carrington
B M
BM
Department of Diagnostic Radiology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
Thomas
N B
NB
Johnson
R J
RJ
D000328:Adult; D000368:Aged; D000792:Angiography / Q000009:adverse effects / Q000379:methods; D002404:Catheterization / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D002445:Celiac Artery; D003287:Contrast Media / Q000009:adverse effects; D004617:Embolism / Q000209:etiology; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D011677:Punctures / Q000009:adverse effects; D012189:Retrospective Studies; D013157:Splenic Artery / Q000000981:diagnostic imaging*; D013927:Thrombosis / Q000209:etiology
D003287:Contrast Media; D007376:Interleukin-2