[Borrelia burgdorferi may be the causal agent of sarcoidosis].
Serum antibody to Borrelia burgdorferi was measured in 33 patients with sarcoidosis who were confirmed clinically and pathologically. The results showed that 81.8% of the patients were positive. In addition, a strain of Borrelia burgdorferi was isolated from a patient's blood. Fourteen patients received ceftriaxone 2 g per day and/or penicillin 12 million per day and a patient received lincomycin 1.2 g per day. The antibody titer of the patients turned to normal level, their SACE turned to normal range, and chest X-ray findings were markedly improved in 3 cases after the treatment. According to the facts mentioned above, we consider that Borrelia burgdorferi may be the causal agent of sarcoidosis and sarcoidosis might be a special type of Lyme disease.
Hua
B
B
Naval General Hospital of PLA, Beijing.
Li
Q D
QD
Wang
F M
FM
D000328:Adult; D000907:Antibodies, Bacterial / Q000378:metabolism; D015748:Borrelia burgdorferi Group / Q000276:immunology; D002443:Ceftriaxone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008193:Lyme Disease; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D012507:Sarcoidosis / Q000188:drug therapy / Q000382:microbiology*
D000907:Antibodies, Bacterial; D010406:Penicillins; D002443:Ceftriaxone