Toxic effects of ackee oil (Blighia sapida L) following subacute administration to rats.
Subacute intraperitoneal administration of the lipid portion of the unripe ackee arillus, referred to as "ackee oil", resulted in marked neutropenia (p less than 0.001) and increase in platelets (p less than 0.01) without anaemia, in rats. Blood urea, sodium and aspartate aminotransferase levels were significantly decreased but glucose and bilirubin levels were similar to those of controls. The lungs showed areas of petechial haemorrhages and a dose-related perivascular and peribronchial mononuclear cell infiltration. The pulmonary toxicity may be interpreted as a hypersensitive reaction to ackee oil. Further research is in progress on the neutropenic effects of ackee oil.
Singh
P
P
Department of Pharmacology, Anatomy, U.W.I., Jamaica.
Gardner
M
M
Poddar
S
S
Choo-Kang
E
E
Coard
K
K
Rickards
E
E
D000818:Animals; D007563:Jamaica; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009503:Neutropenia / Q000139:chemically induced; D010936:Plant Extracts / Q000633:toxicity; D010938:Plant Oils / Q000378:metabolism / Q000633:toxicity*; D010976:Platelet Count / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D010936:Plant Extracts; D010938:Plant Oils