title: Characteristics of trabecular bone resorption cavities in patients with chronic renal failure.
abstract: Using a computerised technique, resorption cavity characteristics in iliac crest trabecular bone were assessed in 30 patients with chronic renal failure and compared with data obtained from healthy subjects. The mean and maximum cavity depth were significantly greater in the patient group (P less than 0.0001); in addition, cavity area, the percentage of bone being remodelled, the number of cavities per mm trabecular surface and the percentage eroded surface were all significantly greater than in controls (P less than 0.0001). However, the surface length of individual cavities in the patient group did not differ significantly from that of controls. In the patient group, serum intact parathyroid hormone concentrations showed a significant positive correlation with mean resorption cavity depth (r = 0.451, P less than 0.05). Our results demonstrate that the increase in bone resorption associated with hyperparathyroidism secondary to chronic renal failure is due to an increase both in the number and depth of cavities, although the surface extent of individual cavities is normal. These findings indicate that factors determining the length of trabecular surface eroded and the depth of individual resorption cavities are controlled by different mechanisms.
authors.affiliation: Department of Pathology, University of Wales College of Medicine, Cardiff, UK.
authors.forename: P I
authors.initials: PI
authors.lastname: Croucher
authors.forename: C D
authors.initials: CD
authors.lastname: Wright
authors.forename: N J
authors.initials: NJ
authors.lastname: Garrahan
authors.forename: H
authors.initials: H
authors.lastname: Kudlac
authors.forename: A J
authors.initials: AJ
authors.lastname: Williams
authors.forename: J E
authors.initials: JE
authors.lastname: Compston
mesh_terms: D000328:Adult; D000368:Aged; D001862:Bone Resorption / Q000209:etiology / Q000473:pathology*; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged