[Presence of inhibitors of activated partial thromboplastin time (TTPA). Clinical repercussion in obstetric patients].
Partial thromboplastin time, activated with kaolin (TTPA) is a qualitative test used to find defects of some factor of intrinsic via of coagulation or to rule out the presence of some circulating inhibitor. The lupus anticoagulant (LA) is part of a group of several auto-antibody with pathogenic potential in several branches of medicine, mainly rheumatology, hematology and gyneco-obstetrics. In this last area the LA has been associated with different obstetrical repercussions. The purpose of this study was to determine the main obstetrical events associated with patients with circulating anticoagulants identified by TTPA with kaolin. Ninety six patients were included in cases-control study. Group I (n = 48) cases and Group II (n = 48) controls, were selected from the same population and information source. The cases were included when presenting prolongation of more than 4 seconds of TTPA activated with kaolin regarding a control with lack of correction with normal plasma. A registration sheet for data captation, was designed specially for this study. The comparability of both groups was established, as there were no differences (significant) among the variable considered as basal. The group of cases presented with a greater frequency of habitual abortion, neonatal death and thrombotic phenomena. This relationship of autoimmunological pictures with recurrent fetal loss and thromboembolic incidents has been consistently described in literature. To this respect, several immunological abnormalities. Including positive anticardiolipin antibodies and VDRL falsely positive. The incidence, in this country of these entities, is unknown. These observations show the need of a methodologic superation.(ABSTRACT TRUNCATED AT 250 WORDS)
Bustos
H H
HH
Clínica de Esterilidad, Instituto Nacional de Perinatología, México, D.F.
Huber
R
R
Baptista
H
H
Izquierdo
H
H
Sánchez Contreras
J
J
D000026:Abortion, Habitual / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007226:Infant Mortality; D010314:Partial Thromboplastin Time; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
Presencia de inhibidores del tiempo tromboplastina parcial activada (TTPA). Repercusión clínica en pacientes obstétricas.