Effect of fenfluramine on mood: a double-blind placebo-controlled trial.
Depressed patients (n = 10), schizophrenics (n = 6), and normal control subjects was (n = 9) were administered fenfluramine hydrochloride (FF) (60 mg/os) or placebo in the context of a randomized, double-blind crossover trial. No effect of FF on mood or activation was detected over a 6-hr period. A previous report claiming acute antidepressant effects of FF in depressed subjects was not confirmed.
Lichtenberg
P
P
Department of Research, Ezrath Nashim Hospital, Jerusalem, Israel.
Shapira
B
B
Blacker
M
M
Gropp
C
C
Calev
A
A
Lerer
B
B
D000328:Adult; D000339:Affect / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D005260:Female; D005277:Fenfluramine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D005277:Fenfluramine