[Inhibition of growth and metastasis of Lewis lung carcinoma in C57BL mice immunized with PGE2-bovine thyroglobulin conjugate].
C57BL mice were immunized with PGE2 with bovine thyroglobulin (BTG) as protein carrier. One week after immunization, mice were challenged with Lewis carcinoma cells, a tumor with high endogenous production of PGE2. A group of mice orally treated with indomethacin (INDO) was similarly inoculated with the tumor cells for comparison. The results indicated that the PGE2 content in the tumor, as determined by RIA, was very much reduced in both PGE2-immunized and INDO-treated animals. Marked inhibition of tumor growth was observed in PGE2-immunized and in INDO-treated mice, with inhibition rates of 57.4% and 63.1%, respectively. In addition, much less number of lung metastatic foci developed in the two groups of mice as compared to the control (P less than 0.002). BTG had no influence at all on tumor growth and metastatic spread. The results support the view that PGE2 plays an important role in tumor development and metastasis.
Li
W
W
Hubei Medical College First Hospital, Wuhan.
D000818:Animals; D015232:Dinoprostone / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use; D004337:Drug Carriers; D005260:Female; D007114:Immunization; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013954:Thyroglobulin / Q000008:administration & dosage
D004337:Drug Carriers; D013954:Thyroglobulin; D015232:Dinoprostone