title: [Primary malignant teratoma of the thyroid. Two cases involving immunohistochemical and ultrastructural studies].
abstract: Two cases of primary malignant teratoma of the thyroid are reported. The first case, which occurred in a 21-year-old female, was mostly composed of tumoral neural tissue and foci of foetal cartilage. The patient died with lung metastases within 5 months after the first symptoms. The second case, which occurred is a 8-year-old infant female, had epithelial and mesenchymal components without neural tissue. This case had a better prognosis with survival of four years after initial diagnosis. The different tumoral components were identified by a thorough histopathological examination of the thyroidectomy with immunological and ultrastructural studies. As for other teratomas, presence of immature neural tissue bore a poor prognosis. The clinical, histopathological features and the histogenesis of this rare tumour are described and literature is reviewed.
authors.affiliation: Service d'Anatomie et de Cytologie Pathologiques A, Faculté de Médecine de Lille.
authors.forename: M
authors.initials: M
authors.lastname: Lecomte-Houcke
authors.forename: M
authors.initials: M
authors.lastname: Parent
authors.forename: B
authors.initials: B
authors.lastname: Carnaille
authors.forename: M C
authors.initials: MC
authors.lastname: Baranzelli
authors.forename: G
authors.initials: G
authors.lastname: Chauvet-Hogedez
authors.forename: C
authors.initials: C
authors.lastname: Proye
authors.forename: A
authors.initials: A
authors.lastname: Dupont
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary; D011379:Prognosis; D013724:Teratoma / Q000737:chemistry* / Q000556:secondary / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000648:ultrastructure; D013965:Thyroidectomy
vernacular_title: Teratomes malins primitifs de la thyroïde. Deux observations avec études immunohistochimique et ultrastructurale.