title: Action of Escherichia coli heat-stable enterotoxin II on isolated sections of mouse ileum.
abstract: When Escherichia coli STII was applied to the serosa of the ileum at a concentration of 40 micrograms/ml, an acceleration of the spontaneous motility and a weak contraction were induced 2-3 min later. The induction was not affected by the addition of atropine (10(-6) M), but was abolished by the addition of papaverine (10(-4) M). When STII was applied to the mucosa, the acceleration of the spontaneous motility appeared 7-8 min later, but a contraction was not induced. These results suggest that STII acts directly on muscle cell of the ileum and enhances the spontaneous motility of the intestine.
authors.affiliation: Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hitotsubashi
authors.forename: M
authors.initials: M
authors.lastname: Akagi
authors.forename: A
authors.initials: A
authors.lastname: Saitou
authors.forename: H
authors.initials: H
authors.lastname: Yamanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001427:Bacterial Toxins / Q000633:toxicity*; D003470:Culture Media; D004768:Enterotoxins / Q000633:toxicity*; D004926:Escherichia coli; D029968:Escherichia coli Proteins; D005769:Gastrointestinal Motility / Q000187:drug effects; D006358:Hot Temperature; D007082:Ileum / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010208:Papaverine / Q000494:pharmacology
chemical_list: D001427:Bacterial Toxins; D003470:Culture Media; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C034151:heat stable toxin (E coli); D001285:Atropine; D010208:Papaverine