Effect of swimming on prednisolone-induced osteoporosis in elderly rats.
We investigated the possible ameliorating and preventive effect of swimming on prednisolone-induced osteoporosis in elderly rats. A total of 48 female Sabra strain rats were randomly assigned to the following groups and treatments: (1) control (C), (2) swimming (S), (3) prednisolone-treated (CP), and (4) swimming + prednisolone (SP). An additional 8 rats were sacrificed and examined at the onset of the study. Groups C and S were sham injected; groups CP and SP were injected with prednisolone (Ultracorten), 80 mg/kg three times per week for 10 weeks. Groups S and SP swam 1 h daily, 5 days per week for 10 weeks. SP rats swam simultaneously with prednisolone administration. At the end of the swimming period, in vivo bone mineral content (BMC) measurements were performed on rat vertebrae L4-5 by single-photon absorptiometry. Later, the humerus and femur were removed for the following measurements: morphometric, bone density (BD) by Compton scattering technique, bone ion content by atomic absorption, and hydration fraction by proton magnetic resonance (PMR). We found that the humeral BD of S rats was greater by 14% for group S over C and 3% greater for group SP over CP (P less than 0.05). Vertebral BMC was higher by 15% in group S over C and 11% higher for group SP over CP (P less than 0.05). Femoral calcium (mg/g dry bone) ion content was higher by 5% in group S over C and 8% in group SP over CP group (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Swissa-Sivan
A
A
Jerusalem Center for Osteoporosis, Israel.
Statter
M
M
Brooks
G A
GA
Azevedo
J
J
Viguie
C
C
Azoury
R
R
Greenfield
C
C
Oman
S
S
Leichter
I
I
Zinker
B A
BA
D000375:Aging / Q000502:physiology*; D000818:Animals; D001834:Body Water / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000502:physiology; D005260:Female; D007477:Ions; D009682:Magnetic Resonance Spectroscopy; D010024:Osteoporosis / Q000139:chemically induced / Q000517:prevention & control*; D011239:Prednisolone; D051381:Rats; D013550:Swimming
D007477:Ions; D011239:Prednisolone