IgG antibody against GM1, GD1b and asialo-GM1 in chronic polyneuropathy following Mycoplasma pneumoniae infection.
Serum IgG in a patient with chronic polyneuropathy after Mycoplasma pneumoniae infection reacted with ganglioside GM1, GD1b and asialo-GM1 on thin-layer chromatograms using an immunostaining technique as well as an enzyme-linked immunosorbent assay, suggesting that the galactosyl (beta 1-3)N-acetylgalactosaminyl moiety could be a target antigen in this patient. Serum IgG reacting with these glycolipids may be involved in the pathogenesis of both motor and sensory neuropathies in this patient.
Yoshino
H
H
Department of Neurology, Niigata University, Japan.
Inuzuka
T
T
Miyatake
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D002648:Child; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011019:Pneumonia, Mycoplasma / Q000276:immunology*; D011129:Polyradiculoneuropathy / Q000175:diagnosis / Q000276:immunology*
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside