A general method for calculating the mean transit times and distribution rate parameters of catenary metabolites.
A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precursor order and does not require separate administration of the metabolite. The approach is applied to published data for the primary and secondary metabolites of ketamine.
Cheng
H
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Department of Drug Metabolism, Merck Sharp and Dohme Research Laboratories, West Point, PA 19486.
D005772:Gastrointestinal Transit; D006801:Humans; D007649:Ketamine / Q000097:blood / Q000378:metabolism; D008433:Mathematics; D010599:Pharmacokinetics; D014018:Tissue Distribution
D007649:Ketamine