title: Koningic acid (heptelidic acid) inhibition of glyceraldehyde-3-phosphate dehydrogenases from various sources.
abstract: Koningic acid is a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which binds to the cysteine residue at the active site. We have determined sensitivity of GAPDHs in comparison with their amino acid sequences. It was found that koningic acid sensitivity of GAPDHs is highly dependent on the sequences of the S-loop domain of the enzyme.
authors.affiliation: Department of Applied Biological Science, Tokyo Noko University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: A
authors.initials: A
authors.lastname: Endo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002645:Chickens; D004912:Erythrocytes / Q000201:enzymology; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors*; D006801:Humans; D008969:Molecular Sequence Data; D009132:Muscles / Q000201:enzymology; D012717:Sesquiterpenes / Q000494:pharmacology; D013552:Swine
chemical_list: D012717:Sesquiterpenes; C027285:heptelidic acid; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases