Safety and immunogenicity of combined rabies and typhoid fever immunization.
The prevalence of rabies and typhoid fever in many developing countries poses a serious health hazard to travellers. The development of a combined immunization schedule would be advantageous. A study was performed on 104 adult volunteers using purified Vero cell rabies vaccine and Typhim Vi, a purified capsular polysaccharide, either separately or in combination. No significant difference was observed in immunogenicity or tolerance between the two groups. A 3-year follow-up study is planned.
Fritzell
C
C
Centre Antirabique, Hôpital de l'Institut Pasteur, Paris, France.
Rollin
P E
PE
Touir
M
M
Sureau
P
P
Teulieres
L
L
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D012485:Salmonella typhi / Q000276:immunology; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D011135:Polysaccharides, Bacterial; D011819:Rabies Vaccines; D014436:Typhoid-Paratyphoid Vaccines; C057664:Vi polysaccharide vaccine, typhoid