[Evaluating the effectiveness of chemotherapy in patients with head-neck tumors using positron emission tomography (PET scan)].
Positron emission tomography (PET) demonstrates the qualitative and quantitative characteristics of multiple metabolic pathways. In a prospective study we evaluated the metabolism of glucose in the tumors of ten patients suffering from head and neck cancer before and after chemotherapy with cisplatin and 5-fluorouracil. Using 18-fluorodeoxyglucose (FDG), it was possible to show changes in tumor metabolism after chemotherapy. In general, chemotherapy reduced the volume of the primary tumor and the lymph nodes. There was a linear relation between the changes in metabolism and growth rate, but in a few patients the lymph nodes and the primary tumor showed a different metabolic reaction. With FDG metabolism and PET we were able to determine the response rate of the tumor in vivo before chemotherapy.
Seifert
E
E
HNO-Klinik, Klinikum Mannheim, Fakultät für klinische Medizin der Universität Heidelberg.
Schadel
A
A
Haberkorn
U
U
Strauss
L G
LG
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism*; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy*; D002455:Cell Division / Q000502:physiology; D002945:Cisplatin / Q000008:administration & dosage; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D019788:Fluorodeoxyglucose F18; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D009959:Oropharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011446:Prospective Studies; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D002945:Cisplatin; D005472:Fluorouracil
Die Beurteilung der Effektivität einer Chemotherapie bei Patienten mit Kopf-Hals-Tumoren mittels Positronenemissionstomographie (PET).