Vitamin E levels in gastric mucosa and indomethacin-induced gastric lesions in rats.
The role of vitamin E as a gastroprotective agent from indomethacin-induced damage was investigated in male rats with deficient or supplemented levels of vitamin E in their blood and tissues. Ten weeks of feeding a vitamin E deficient diet produced very low levels of the vitamin in all the tissues studied (below 1.2 micrograms/g tissue). Ten weeks of feeding a diet high in vitamin E content produced high levels of vitamin E in fundus (26 micrograms/g), antrum (18 micrograms/g), duodenum (21 micrograms/g), liver (41 micrograms/g) and plasma (11 micrograms/ml). Oral administration of indomethacin (15 mg/kg) to rats deficient or supplemented with vitamin E resulted in similar degrees of injuries to their gastric mucosa. These data together with previous results indicates that if vitamin E functions as an antioxidant in vivo, lipid peroxidation is not the main cause of gastric damage due to indomethacin.
Zaror-Behrens
G
G
Bureau of Human Prescription Drugs, GEHO Division, Vanier, Ontario, Canada.
Greselin
E
E
Madere
R
R
Behrens
W A
WA
D000284:Administration, Oral; D000818:Animals; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage / Q000378:metabolism*
D014810:Vitamin E; D007213:Indomethacin