Primary cutaneous plasmacytoma: the use of in situ hybridization to detect monoclonal immunoglobulin light-chain mRNA.
A case of primary cutaneous plasmacytoma in a 16-year-old male is described. The neoplastic nature of the plasma cell infiltrate has been clearly established by the demonstration of monoclonal kappa immunoglobulin light-chain mRNA using in situ hybridization with biotin-labelled oligonucleotide probes applied to routine tissue sections.
Walker
E
E
Department of Pathology, Royal Infirmary, Glasgow, Scotland, UK.
Robertson
A G
AG
Boorman
J G
JG
McNicol
A M
AM
D000293:Adolescent; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D008297:Male; D009693:Nucleic Acid Hybridization; D010954:Plasmacytoma / Q000235:genetics* / Q000276:immunology; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis*; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology
D007147:Immunoglobulin Light Chains; D012333:RNA, Messenger; D012334:RNA, Neoplasm