Inhibition of urea transport across renal tubules by pyrazinoylguanidine and analogs.
In addition to glomerular filtration and passive back diffusion of urea, there occurs across the renal tubule bidirectional transport of urea inhibitable in one or both directions by specific analogs of pyrazinoylguanidine (PZG). Effect of PZG on the profiles of sodium and urea concentrations along the tubule (stop flow) are consistent with their independent transport. Inhibition of urea and sodium reabsorption by PZG is dose dependent. PZG does not inhibit potassium excretion.
Beyer
K H
KH
Department of Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey 17033.
Gelarden
R T
RT
Vesell
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ES
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate; D006146:Guanidines / Q000494:pharmacology*; D007684:Kidney Tubules / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism; D013329:Structure-Activity Relationship; D014508:Urea / Q000037:antagonists & inhibitors* / Q000378:metabolism
D006146:Guanidines; D011719:Pyrazines; C056104:2-pyrazinoylguanidine; D000584:Amiloride; D014508:Urea; D012964:Sodium; D011188:Potassium