In vivo fluoride concentrations measured for two hours after a NaF or a novel two-solution rinse.
The concentrations of fluoride in various samples from the oral environment were measured at timed intervals after a novel rinse or a NaF rinse, both containing a total of 12 mmol/L (228 ppm) fluoride. The novel rinse consisted of two solutions mixed just before application: Part A contained calcium chloride and sodium acetate; part B contained a hydrolyzable source of fluoride (sodium hexafluorosilicate) and sodium phosphate. Samples were obtained as follows: Single-site plaque-fluid samples were obtained by centrifugation of first-molar plaque; pooled whole-plaque samples were collected from second molars; centrifuged, pooled whole-saliva was collected by vacuum. All samples were analyzed by micro-analytical methods. Results showed that, compared with NaF, the two-solution rinse produced significantly higher salivary fluoride concentrations, plaque-fluid fluoride concentrations, and acid-extractable fluoride in the whole plaque by factors of about 4, 2, and 6, respectively, at 120 min. The results of this study suggest that the new rinse may provide a greater cariostatic effect at the same fluoride dosage than does a NaF rinse.
Vogel
G L
GL
American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standard Technology, Gaithersburg, Maryland 20899.
Mao
Y
Y
Carey
C M
CM
Chow
L C
LC
Takagi
S
S
D000328:Adult; D002122:Calcium Chloride / Q000008:administration & dosage / Q000627:therapeutic use; D003773:Dental Plaque / Q000737:chemistry*; D005122:Exudates and Transudates / Q000737:chemistry; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012636:Secretory Rate; D012824:Silicic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D009067:Mouthwashes; D010710:Phosphates; D012824:Silicic Acid; C004832:hexafluorosilicate; D012969:Sodium Fluoride; D002122:Calcium Chloride; D005459:Fluorides; C018279:sodium phosphate