title: Intermediate filament dynamics.
abstract: The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place. This incorporation appears to be required for maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational level, phosphorylation is an important factor in regulating dynamic aspects of intermediate filament organization and structure.
authors.affiliation: Department of Cell, Molecular and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611-3008.
authors.forename: J E
authors.initials: JE
authors.lastname: Eriksson
authors.forename: P
authors.initials: P
authors.lastname: Opal
authors.forename: R D
authors.initials: RD
authors.lastname: Goldman
mesh_terms: D000818:Animals; D007381:Intermediate Filament Proteins / Q000378:metabolism; D007382:Intermediate Filaments / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation
chemical_list: D007381:Intermediate Filament Proteins