Robustness of the no-interference model for ordering genetic markers.
Under the assumption of no chromatid interference, we derive constraints on the probabilities of the different recombination patterns among m + 1 genetic loci. An application of these constraints is a proof that the ordering of the loci that maximizes the likelihood under the assumption of no interference is, in fact, a consistent estimator of the true order even when there is interference.
Speed
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Department of Statistics, University of California, Berkeley 94720.
McPeek
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Evans
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D002842:Chromatids / Q000648:ultrastructure; D002874:Chromosome Mapping / Q000379:methods; D008040:Genetic Linkage; D016013:Likelihood Functions; D011336:Probability; D011995:Recombination, Genetic