title: Accelerated aging of the brain in Werner's syndrome.
abstract: We report the electrophysiologic examination of a 55-year-old woman with Werner's syndrome. Needle EMG and peripheral conduction studies were normal. In contrast, EEG was moderately abnormal, the N20 and P25 potentials of SEPs were delayed and enlarged, and the event-related potential, P300, was delayed. These characteristic findings indicated accelerated aging of the brain, as in the other organs, in Werner's syndrome.
authors.affiliation: Department of Internal Medicine, Saga Medical School, Nabeshima, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Kakigi
authors.forename: C
authors.initials: C
authors.lastname: Endo
authors.forename: R
authors.initials: R
authors.lastname: Neshige
authors.forename: H
authors.initials: H
authors.lastname: Kohno
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D004576:Electromyography; D016057:Evoked Potentials, Auditory, Brain Stem; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009431:Neural Conduction; D014898:Werner Syndrome / Q000175:diagnosis / Q000503:physiopathology*