title: Chronic progressive CNS histoplasmosis presenting in childhood: response to fluconazole therapy.
abstract: An 18-year-old Hispanic female developed symptoms of a Histoplasma capsulatum infection at 9 1/2 years of age. Initial problems of ataxia and hydrocephalus were followed by seizures and a cranial nerve palsy which developed over several years. T1-weighted cranial magnetic resonance imaging studies revealed numerous high-signal lesions; subsequently, signs of multisystem dissemination developed. Treatment included ventriculoperitoneal shunting, corticosteroids, amphotericin B, and a new antifungal agent, fluconazole, which was responsible for marked improvement.
authors.affiliation: Department of Neurology, University of Miami School of Medicine, Florida.
authors.forename: I V
authors.initials: IV
authors.lastname: Rivera
authors.forename: R G
authors.initials: RG
authors.lastname: Curless
authors.forename: F J
authors.initials: FJ
authors.lastname: Indacochea
authors.forename: G B
authors.initials: GB
authors.lastname: Scott
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy*; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination
chemical_list: D015725:Fluconazole