Mass treatment of filariasis using DEC-medicated salt.
Diethylcarbamazine (DEC)-medicated salt was used to control bancroftian filariasis in 20 endemic counties and cities of Fujian Province in China. The population was 5,189,126 and the microfilaria (mf) rates were between 1.56 and 11.81%. The total dose of DEC was 6-10.5 g per person over a period of 2-4 months. Six to 9 months after treatment the mf rate was reduced to 0-0.57% with a mean of 0.07% (621/823,796). In 184 villages sampled one year post treatment the mf rate was 0.22% (371/171,067) and in 29 villages 2-4 years after treatment the mf rate was 0.05% (31/56,459). In a region of endemic Malayan filariasis, with a population of 67,778 and mf rate of 3.82-4.36%, treatment with DEC-medicated salt to a dosage of 3.2 g DEC per person was administered for 2 months. Six months after treatment the mean mf rate was reduced from 4.08 to 0.26% (10/3841). Filariasis in all the villages controlled with DEC-medicated salt reached the basic criteria of elimination (mf rate below 1%).
Liu
J
J
Fujian Provincial Institute of Parasitic Diseases, Fuzhou, PR China.
Chen
Z
Z
Huang
X
X
Tu
Z
Z
D000818:Animals; D002009:Brugia / Q000302:isolation & purification; D002681:China / Q000453:epidemiology; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004605:Elephantiasis, Filarial / Q000188:drug therapy*; D005368:Filariasis / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D008842:Microfilariae / Q000302:isolation & purification; D010349:Patient Compliance; D012982:Sodium, Dietary; D014958:Wuchereria bancrofti / Q000302:isolation & purification
D012982:Sodium, Dietary; D004049:Diethylcarbamazine