Serum androstanediol glucuronide in women with facial hirsutism.
BACKGROUND
Measurement of serum 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (3 alpha-diolG) has been proposed as a useful biochemical marker of peripheral androgen metabolism. Is 3 alpha-diol G a useful biochemical marker of peripheral androgen metabolism and does it correlate with degree of facial hirsutism?


OBJECTIVE
Our purpose was to assess possible correlation between serum 3 alpha-diol G and degree of facial hirsutism and to compare serum 3 alpha-diol G levels with levels of other commonly measured serum androgens.


METHODS
Twenty-three consecutive women with facial hirsutism were studied, and serum concentrations of 3 alpha-diol G, testosterone (total, free, and biologically active portions), dehydroepiandrosterone sulfate, and androstenedione were measured.


RESULTS
There was no correlation between serum 3 alpha-diol G levels and degree of facial hirsutism. There was a correlation between levels of 3 alpha-diol G and dehydroepiandrosterone sulfate (p less than 0.01), biologically active testosterone (p = 0.01), free free testosterone (p less than 0.02), and androstenedione (p less than 0.05).


CONCLUSIONS
Serum 3 alpha-diol G concentrations have no correlation with degree of facial hirsutism and do not provide additional information over the commonly measured androgens.
Salman
K
K
Division of Endocrinology, Hahnemann University Hospital, Philadelphia, PA 19102.
Spielvogel
R L
RL
Shulman
L H
LH
Miller
J L
JL
Vanderlinde
R E
RE
Rose
L I
LI
D000293:Adolescent; D000328:Adult; D000728:Androgens / Q000097:blood; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005148:Facial Dermatoses / Q000097:blood*; D005260:Female; D006628:Hirsutism / Q000097:blood*; D006801:Humans
D000728:Androgens; D015415:Biomarkers; D015113:Androstane-3,17-diol; C028895:androstane-3,17-diol glucuronide