title: Seasonal changes in cell mediated immune responses to soluble Plasmodium falciparum antigens in children with haemoglobin AA and haemoglobin AS.
abstract: In this longitudinal study peripheral blood mononuclear cells (PBMC) were obtained before and during the malaria season from healthy HbAA and HbAS children. Cells were compared for proliferation in response to stimulation by soluble Plasmodium falciparum antigens (SPAg) or purified derivative of tuberculin (PPD). The lymphoproliferative responses to SPAg of the paired PBMC samples showed 2 distinct seasonal changes in relation to the haemoglobin phenotype. In HbAA children, the lymphoproliferative responses to SPAg were suppressed during the malaria season. In contrast, they were enhanced in HbAS children during the malaria season. No distinct seasonal change in the response to PPD was found in relation to the haemoglobin phenotype. The study points to the role of the sickle cell trait in modulating the cellular immune responses to falciparum malaria.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, University of Khartoum, Sudan.
authors.forename: Y A
authors.initials: YA
authors.lastname: Abu-Zeid
authors.forename: N H
authors.initials: NH
authors.lastname: Abdulhadi
authors.forename: T G
authors.initials: TG
authors.lastname: Theander
authors.forename: L
authors.initials: L
authors.lastname: Hviid
authors.forename: B O
authors.initials: BO
authors.lastname: Saeed
authors.forename: S
authors.initials: S
authors.lastname: Jepsen
authors.forename: J B
authors.initials: JB
authors.lastname: Jensen
authors.forename: R A
authors.initials: RA
authors.lastname: Bayoumi
mesh_terms: D000293:Adolescent; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D006441:Hemoglobin A / Q000737:chemistry*; D006451:Hemoglobin, Sickle / Q000737:chemistry*; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008938:Mitosis; D009000:Monocytes / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D012621:Seasons
chemical_list: D000953:Antigens, Protozoan; D006451:Hemoglobin, Sickle; C028672:hemoglobin AA; C028671:hemoglobin AS; D006441:Hemoglobin A