title: Inching toward reality: an improved likelihood model of sequence evolution.
abstract: Our previous evolutionary model is generalized to permit approximate treatment of multiple-base insertions and deletions as well as regional heterogeneity of substitution rates. Parameter estimation and alignment procedures that incorporate these generalizations are developed. Simulations are used to assess the accuracy of the parameter estimation procedure and an example of an inferred alignment is included.
authors.affiliation: Department of Genetics SK-50, University of Washington, Seattle 98195.
authors.forename: J L
authors.initials: JL
authors.lastname: Thorne
authors.forename: H
authors.initials: H
authors.lastname: Kishino
authors.forename: J
authors.initials: J
authors.lastname: Felsenstein
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D008969:Molecular Sequence Data; D016415:Sequence Alignment
chemical_list: D004247:DNA