Ito cells and fibrogenesis in chronic alcoholic liver disease.
The relationships between the number of Ito cells; serum N-terminal type III procollagen and laminin; clinical and biochemical parameters of liver function derangement; histomorphometrically assessed total amount of liver fibrosis; and daily ethanol intake were studied in 43 patients affected by chronic alcoholic liver disease (10 cirrhotics). Significant correlations were found between serum laminin and N-terminal type III procollagen and histological, clinical and biochemical data of liver function derangement, but no correlation was found between the aforementioned parameters and the percentage of Ito cells, which in turn seemed to be related to ethanol ingestion.
González-Reimers
C E
CE
Dpto. de Medicina Interna, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
Brajín-Rodríguez
M M
MM
Santolaria-Fernández
F
F
Diaz-Flores
L
L
Conde-Martel
A
A
Rodríguez-Rodríguez
E
E
Essardas-Daryanani
H
H
D000273:Adipose Tissue / Q000473:pathology; D001707:Biopsy, Needle; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D007797:Laminin / Q000097:blood*; D008099:Liver / Q000473:pathology*; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood / Q000473:pathology*; D008111:Liver Function Tests; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*
D007797:Laminin; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide