title: Neutralization of the effects of captopril by the use of ibuprofen in an elderly woman.
abstract: This case report demonstrates that the antihypertensive effects of captopril were neutralized by the concomitant administration of ibuprofen. If elderly patients on ACE inhibitors show evidence of a "noncompliant" worsening of their hypertension, a thorough review of all the patient's medications, including the use of over-the-counter ibuprofen, should be undertaken.
authors.affiliation: Department of Family Practice, University of Texas Health Science Center, San Antonio 78284-7795.
authors.forename: D V
authors.initials: DV
authors.lastname: Espino
authors.forename: M C
authors.initials: MC
authors.lastname: Lancaster
mesh_terms: D000368:Aged; D002216:Captopril / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010003:Osteoarthritis / Q000188:drug therapy; D013467:Sulindac / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D013467:Sulindac; D002216:Captopril; D007052:Ibuprofen