Comparison of laser Doppler fluxmetry and the thermal diffusion method of measuring skin blood flow with hydrogen clearance.
Laser Doppler fluxmetry (LDF) and the thermal diffusion method (TDF) were compared with the hydrogen clearance method in ten rabbit ears. The LDF signal followed the rapid change in blood flow caused by aortic occlusion and the signal obtained by TDF showed a time delay and the response was less steep compared with the LDF signal. Simultaneous recording showed both methods correlated well with the hydrogen clearance method, but the relationship varied among the studies (the slope 0.0189-0.0967 for LDF, the slope 0.052-0.682 for TDF). Both methods appear to provide a good indicator of the response pattern of blood flow in the region tested. However, variability among the subjects indicates that the quantitative application of both techniques is difficult.
Tamura
T
T
Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.
Togawa
T
T
Yokoyama
K
K
D000818:Animals; D004058:Diffusion; D006859:Hydrogen / Q000493:pharmacokinetics*; D007834:Lasers; D008657:Metabolic Clearance Rate / Q000502:physiology; D011817:Rabbits; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D013696:Temperature
D006859:Hydrogen