title: Management of dysfunction in the transplanted lung: experience with 7 clinical cases. Washington University Lung Transplant Group.
abstract: In a series of 34 lung transplant patients, donor lung dysfunction occurred on 7 occasions. One patient underwent retransplantation and the remaining 6 were treated conservatively. Survival was 100% in the donor lung dysfunction group. Percent predicted forced expiratory volume in 1 second, carbon monoxide diffusion, room air oxygen tension, and distance walked in 6 minutes were all lower (p less than 0.05) at 1 month after transplantation in those patients with donor lung dysfunction as compared with those without. These differences were not significant at 3 months after transplantation. We conclude that donor lung dysfunction can usually be managed conservatively with satisfactory results. Longer follow-up of this group of patients will be necessary to determine the long-term consequences of early graft injury.
authors.affiliation: Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.
authors.forename: D A
authors.initials: DA
authors.lastname: Haydock
authors.forename: E P
authors.initials: EP
authors.lastname: Trulock
authors.forename: L R
authors.initials: LR
authors.lastname: Kaiser
authors.forename: S R
authors.initials: SR
authors.lastname: Knight
authors.forename: M K
authors.initials: MK
authors.lastname: Pasque
authors.forename: J D
authors.initials: JD
authors.lastname: Cooper
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical / Q000009:adverse effects; D002248:Carbon Monoxide / Q000097:blood; D015331:Cohort Studies; D003422:Critical Care; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006801:Humans; D007902:Length of Stay; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000209:etiology / Q000503:physiopathology; D016040:Lung Transplantation / Q000502:physiology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion / Q000502:physiology; D011667:Pulmonary Veins / Q000601:surgery; D012086:Reoperation; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D015996:Survival Rate
chemical_list: D002248:Carbon Monoxide; D010100:Oxygen