Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease.
In a case/control study, serum concentrations of vitamins A and E and major carotenoids were determined in patients with Alzheimer's disease, multi-infarct dementia and control subjects. The results showed that both Alzheimer's and multi-infarct dementia patients had significantly lower levels of vitamin E and beta-carotene than controls (vitamin E: 18.65 +/- 3.62 mumol/l in Alzheimer's disease and 15.80 +/- 6.93 mumol/l in multi-infarct dementia versus 30.03 +/- 12.03 mumol/l in controls; beta-carotene less than 0.13 to 0.42 mumol/l in Alzheimer's disease and less than 0.13 to 0.30 mumol/l in multi-infarct dementia versus 0.13 to 1.53 mumol/l in controls). Vitamin A was significantly reduced only in the Alzheimer's patients (1.56 +/- 0.78 mumol/l in Alzheimer's disease versus 2.13 +/- 0.86 mumol/l in controls).
Zaman
Z
Z
Department of Chemical Pathology, Central Middlesex Hospital, London.
Roche
S
S
Fielden
P
P
Frost
P G
PG
Niriella
D C
DC
Cayley
A C
AC
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D002338:Carotenoids / Q000097:blood*; D015161:Dementia, Multi-Infarct / Q000097:blood / Q000175:diagnosis; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D012016:Reference Values; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*; D019207:beta Carotene
D005609:Free Radicals; D019207:beta Carotene; D014801:Vitamin A; D014810:Vitamin E; D002338:Carotenoids