Direct mechanomyographic measurement of the myorelaxant action of baclofen and diazepam in normal and reserpinized rats.
A pathologically increased muscle tone is frequently observed. Objective methods for measuring directly the muscle-relaxant action of drugs in laboratory animals are scarce. This study shows that a computerized mechanomyographic method allows the assessment of myorelaxant drugs. The method consists of the successive bending and straightening of the rat's foot in the ankle joint and the separate measurement of resistance of extensors and flexors of the hind foot to passive movements. The two well-known antispastic drugs diazepam and baclofen reduced the normal muscle tone in both groups of muscles in non-treated animals as well as the muscle tone increased by reserpine (10 mg/kg i.p.). The results obtained show that the mechanomyographic method directly and reliably reveals the myorelaxant action of drugs.
Wolfarth
S
S
Department of Neuropharmacology, Polish Academy of Sciences, Kraków.
Kolasiewicz
W
W
Ossowska
K
K
Bober
M
M
D000704:Analysis of Variance; D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000494:pharmacology*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006614:Hindlimb; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects*; D009213:Myography / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology*
D012110:Reserpine; D001418:Baclofen; D003975:Diazepam