Human insulin-specific immunoglobulin G antibody and hypoglycemic attacks after the injection of gold thioglucose.
A 56-year-old woman with granulomas of gold thioglucose in her hips exhibited recurrent bouts of hypoglycemic attacks. The first attack occurred 2 years after the last injection of gold thioglucose, when large amounts of extractable insulin and human insulin-specific antibody were noted in her serum. Histological examination of the resected granulomas showed marked infiltration of lymphocytes, plasma cells, and macrophages containing yellowish-brown granules, which proved to be gold by electron microscopy using X-ray microanalysis. After resection of the granuloma, however, the frequency of the hypoglycemic attacks decreased remarkably as well as the levels of both extractable insulin and human insulin-specific antibody.
Yao
K
K
Diabetes Center, Tokyo Women's Medical College, Japan.
Uchigata
Y
Y
Kyono
H
H
Yokoyama
H
H
Eguchi
Y
Y
Fukushima
H
H
Yamauchi
K
K
Hirata
Y
Y
D000918:Antibody Specificity; D006051:Aurothioglucose / Q000008:administration & dosage / Q000009:adverse effects*; D004577:Electron Probe Microanalysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006046:Gold / Q000032:analysis; D006099:Granuloma / Q000473:pathology; D006615:Hip; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D007267:Injections; D007328:Insulin / Q000097:blood / Q000276:immunology*; D008214:Lymphocytes / Q000473:pathology / Q000648:ultrastructure; D008264:Macrophages / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged
D007074:Immunoglobulin G; D007328:Insulin; D006051:Aurothioglucose; D006046:Gold