title: Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.
abstract: A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.
authors.affiliation: Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709.
authors.forename: C
authors.initials: C
authors.lastname: Walker
authors.forename: T L
authors.initials: TL
authors.lastname: Goldsworthy
authors.forename: D C
authors.initials: DC
authors.lastname: Wolf
authors.forename: J
authors.initials: J
authors.lastname: Everitt
mesh_terms: D000818:Animals; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D004128:Dimethylnitrosamine; D004195:Disease Models, Animal; D007672:Kidney Cortex / Q000473:pathology; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D051381:Rats; D011922:Rats, Mutant Strains
chemical_list: D004128:Dimethylnitrosamine