title: Longitudinal study of bone loss after thyroidectomy and suppressive thyroxine therapy in premenopausal women.
abstract: The effects of suppressive doses of L-thyroxine on the appendicular and axial bone mineral content were followed for 12-36 months after total or subtotal thyroidectomy in 15 premenopausal women. Compared to age-matched controls, these patients had a more marked bone loss of the spinal bone mineral content (2.6 +/- 1.9% vs 0.2 +/- 1.2% per year). The changes in radial cortical bone density were not significantly different from the control group. We conclude that when a suppressive therapy with L-thyroxine is necessary the rate of bone loss should be monitored at regular intervals.
authors.affiliation: Istituto di Clinica Medica Generale, Università di Parma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pioli
authors.forename: M
authors.initials: M
authors.lastname: Pedrazzoni
authors.forename: E
authors.initials: E
authors.lastname: Palummeri
authors.forename: M
authors.initials: M
authors.lastname: Sianesi
authors.forename: R
authors.initials: R
authors.lastname: Del Frate
authors.forename: P P
authors.initials: PP
authors.lastname: Vescovi
authors.forename: M
authors.initials: M
authors.lastname: Prisco
authors.forename: V
authors.initials: V
authors.lastname: Ulietti
authors.forename: D
authors.initials: D
authors.lastname: Costi
authors.forename: M
authors.initials: M
authors.lastname: Passeri
mesh_terms: D000328:Adult; D015519:Bone Density; D001862:Bone Resorption; D002116:Calcitonin / Q000097:blood; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008593:Menopause; D008875:Middle Aged; D011184:Postoperative Period; D013965:Thyroidectomy; D013974:Thyroxine / Q000627:therapeutic use*
chemical_list: D002116:Calcitonin; D013974:Thyroxine