title: Amphicrine carcinoma of the uterine cervix.
abstract: A case of amphicrine carcinoma of the uterine cervix is described in a 27-year-old woman whose initial cervical biopsy specimen showed small cell undifferentiated neuroendocrine carcinoma. Despite an initial complete clinical response to VP-16 and carboplatin, residual tumor was noted in the cervical cone biopsy specimen and she was treated with external-beam irradiation and cesium implants. The neoplasm subsequently metastasized and required additional VP-16 and carboplatin for control. The pathologic features and biologic behavior of this unusual type of neuroendocrine neoplasm are described in this case report.
authors.affiliation: Diagnostic Specialties Laboratory, Bremerton, Washington 98310.
authors.forename: S P
authors.initials: SP
authors.lastname: Hammar
authors.forename: S J
authors.initials: SJ
authors.lastname: Insalaco
authors.forename: R B
authors.initials: RB
authors.lastname: Lee
authors.forename: D E
authors.initials: DE
authors.lastname: Bockus
authors.forename: F L
authors.initials: FL
authors.lastname: Remington
authors.forename: A
authors.initials: A
authors.lastname: Yu
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002454:Cell Differentiation; D003594:Cytoplasmic Granules / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009490:Neurosecretory Systems / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure