[Evaluation of the efficacy of metformin-glibenclamide treatment in overweight non-insulin dependent diabetics].
The authors evaluated the efficacy of treatment with the metformin-glibenclamide combination in 30 non-insulin dependent overweight diabetic patients in poor metabolic control during sulfonylurea treatment. After three months' therapy, a significant reduction of glycaemia, insulinaemia and fructosamine were found. Therefore, the addition of biguanides in those patients, was able to reduce blood glucose levels and to improve insulin resistance. In addition the metformin glibenclamide combination never produced relevant side effects of lactic acidosis, which is the most dangerous event during biguanide treatment.
Laurenti
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Istituto di I Clinica Medica, Università degli Studi di Roma La Sapienza.
Bravi
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Faldetta
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De Mattia
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D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005905:Glyburide / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood; D008687:Metformin / Q000008:administration & dosage*; D008875:Middle Aged; D009765:Obesity; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D008687:Metformin; D005905:Glyburide
Valutazione dell'efficacia del trattamento metformina-glibenclamide in pazienti diabetici non insulino-dipendenti in eccedenza ponderale.