Impact of HIV infection on mycobacterial disease.
The current epidemic of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome has resulted in a worldwide resurgence of tuberculosis. In the United States, the number of new cases of tuberculosis has increased in the past five years, leading to a cumulative excess of about 15,000 cases. The clinical and epidemiologic picture of tuberculosis in AIDS patients differs drastically from the standard presentation of tuberculosis cases in HIV-negative patients. The diagnosis and management of tuberculosis, particularly atypical mycobacterial infections, present a challenge in HIV-infected patients. Prevention of the transmission of disease is a major concern. Since atypical mycobacterial infection and disease pose a greater management challenge, this article summarizes diagnosis and treatment of atypical mycobacterial infection in HIV-positive patients.
Mehta
J B
JB
James H. Quillen College of Medicine of East Tennessee State University, Johnson City.
Morris
F
F
D000328:Adult; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D014481:United States / Q000453:epidemiology