Relationship of anticoagulation and radiographic contrast agents to thrombosis during coronary angiography and angioplasty: are there real concerns?
Radiographic contrast agents are essential for the performance of coronary angiography and angioplasty. Historical data show that thrombosis-related events have occurred since coronary angiography has been performed. Newer non-ionic agents have been shown to be safer than conventional high osmolar ionic agents especially in high risk patients, but concern has been raised about a potentially increased risk of thrombosis with the use of these agents. A review of basic and clinical evidence for this perception does not support the view that an increase in thrombosis-related events has occurred as a results of non-ionic contrast media use in coronary angiographic procedures.
Hill
J A
JA
Division of Cardiology, University of Florida College of Medicine, Gainesville 32610.
Grabowski
E F
EF
D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects; D003287:Contrast Media / Q000009:adverse effects* / Q000494:pharmacology; D017023:Coronary Angiography / Q000009:adverse effects*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D013927:Thrombosis / Q000097:blood / Q000209:etiology*
D000925:Anticoagulants; D003287:Contrast Media; D006493:Heparin