title: Synthesis and antitumor activity of 4'-O-acylanthracyclines.
abstract: 4'-O-Acyl derivatives of doxorubicin, daunorubicin, 13-deoxocarminomycin, 13-deoxo-10-hydroxycarminomycin, 13-deoxo-11-deoxycarminomycin were synthesized through the formation and mild acid hydrolysis of 2-oxazoline intermediates. The antitumor activity of these 4'-O-acyl derivatives against P388 leukemia was similar to or more effective than the parent anthracyclines.
authors.affiliation: Pharmaceutical Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: H
authors.initials: H
authors.lastname: Kawai
authors.forename: N
authors.initials: N
authors.lastname: Komeshima
authors.forename: M
authors.initials: M
authors.lastname: Sakakibara
authors.forename: K
authors.initials: K
authors.lastname: Tatsuta
authors.forename: N
authors.initials: N
authors.lastname: Otake
authors.forename: H
authors.initials: H
authors.lastname: Umezawa
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents