[Primary malignant teratoma of the thyroid. Two cases involving immunohistochemical and ultrastructural studies].
Two cases of primary malignant teratoma of the thyroid are reported. The first case, which occurred in a 21-year-old female, was mostly composed of tumoral neural tissue and foci of foetal cartilage. The patient died with lung metastases within 5 months after the first symptoms. The second case, which occurred is a 8-year-old infant female, had epithelial and mesenchymal components without neural tissue. This case had a better prognosis with survival of four years after initial diagnosis. The different tumoral components were identified by a thorough histopathological examination of the thyroidectomy with immunological and ultrastructural studies. As for other teratomas, presence of immature neural tissue bore a poor prognosis. The clinical, histopathological features and the histogenesis of this rare tumour are described and literature is reviewed.
Lecomte-Houcke
M
M
Service d'Anatomie et de Cytologie Pathologiques A, Faculté de Médecine de Lille.
Parent
M
M
Carnaille
B
B
Baranzelli
M C
MC
Chauvet-Hogedez
G
G
Proye
C
C
Dupont
A
A
D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary; D011379:Prognosis; D013724:Teratoma / Q000737:chemistry* / Q000556:secondary / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000648:ultrastructure; D013965:Thyroidectomy
Teratomes malins primitifs de la thyroïde. Deux observations avec études immunohistochimique et ultrastructurale.