title: [Induction chemotherapy in the treatment of head and neck cancer in advanced stages].
abstract: Fifty patients with inoperable head and neck carcinomas were treated with Cisplatin-5-fluorouracil induction chemotherapy. After 3 years follow-up, characteristics of patients have been studied, that is: age, sex, stage, primary site, histological type, histological grade and performance status. The analysis of chemotherapy treatment and results on primary tumor and lymphatic areas are presented. A total response rate of 83.3% with 22.9% of complete response rate have been observed. Local treatment after chemotherapy is studied. Radiotherapy increased response in 33.4% of cases. Response duration and survival is to have a complete response after systemic and local treatment. Literature is revised.
authors.affiliation: Oncología Médica, Hospital General de Alicante.
authors.forename: C
authors.initials: C
authors.lastname: Balaña
authors.forename: B
authors.initials: B
authors.lastname: Massuti
authors.forename: J
authors.initials: J
authors.lastname: Minguell
authors.forename: J
authors.initials: J
authors.lastname: Talavera
authors.forename: B
authors.initials: B
authors.lastname: Sánchez
authors.forename: C
authors.initials: C
authors.lastname: Pico
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D006801:Humans; D008353:Mannitol / Q000008:administration & dosage; D008787:Metoclopramide / Q000008:administration & dosage; D009367:Neoplasm Staging; D012074:Remission Induction
chemical_list: D008353:Mannitol; D003907:Dexamethasone; D008787:Metoclopramide; D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Quimioterapia de inducción en el tratamiento del cáncer de cabeza y cuello en estadios avanzados.