Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: XXVIII. Intermediate generalizations (Part C).
This is the final section of an intermediate phase of generalizations dealing with aspects of enhancers. It is concluded that a binding type protein(s) complex near a LTR segment. This creates destabilization of heterochromatin that allows transcription mechanisms. If this process is promoted by anomalous enhancer activity such as those produced by chemical inducers which modify chromatin states or cause hypomethylated enhancer regions, then normally repressed embryonic gene products, such as protooncogene growth factors, can be transcribed inappropriately to a specific developmental stage, eg post-embryonically.
Hancock
R L
RL
Canadian Institute of Theoretical Biology, Scott's Bay, Nova Scotia.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002454:Cell Differentiation; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004742:Enhancer Elements, Genetic / Q000187:drug effects; D005326:Fetal Proteins / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008745:Methylation; D008954:Models, Biological; D011519:Proto-Oncogenes / Q000187:drug effects
D002273:Carcinogens; D005326:Fetal Proteins; D004247:DNA