title: Cytogenetic study of acute lymphoblastic leukemia and its correlation with immunophenotype and genotype.
abstract: Among 72 Chinese patients with acute lymphoblastic leukemia (ALL), 50 had clonal chromosomal abnormalities. Structural abnormalities were detected in 42 patients: these included t(9;22) in 9, t(1;19) in 6, t(4;11) in 5, del(11)(q23) in 4, and del(6q) in 4. Adults had a higher incidence of t(9;22) and t(1;19) but a lower incidence of t(4;11) and hyperdiploid greater than 50 karyotype than children. A significant difference was also noted in white blood cell (WBC) count among various karyotypic groups. Patients with chromosomal abnormalities t(9;22), t(1;19), t(4;11) and del(11) (q23) had a shorter complete remission duration as compared with patients free of these abnormalities. Immunophenotyping was performed on 69 patients. All patients with t(9;22), t(1;19), and t(4;11) had B-lineage ALL restricted to certain stages of maturation: groups III and IV, groups IV and V, and group II, respectively (according to the classification of Foon and Tood). Among patients with t(9;22), t(4;11), and del(11)(q23), which have been considered to be associated with acute mixed-lineage leukemia, one each, respectively, showed myeloid antigen expression on the leukemic blasts (My+ ALL). No cross-lineage rearrangements of immunoglobulin (Ig) or T-cell receptor (TCR) genes were detected in these karyotypic subgroups of patients who underwent gene analysis.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
authors.forename: H F
authors.initials: HF
authors.lastname: Tien
authors.forename: C H
authors.initials: CH
authors.lastname: Wang
authors.forename: F Y
authors.initials: FY
authors.lastname: Lee
authors.forename: M C
authors.initials: MC
authors.lastname: Liu
authors.forename: S M
authors.initials: SM
authors.lastname: Chuang
authors.forename: Y C
authors.initials: YC
authors.lastname: Chen
authors.forename: M C
authors.initials: MC
authors.lastname: Shen
authors.forename: D T
authors.initials: DT
authors.lastname: Lin
authors.forename: K H
authors.initials: KH
authors.lastname: Lin
authors.forename: W M
authors.initials: WM
authors.lastname: Chuu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics*; D015139:Blotting, Southern; D001854:Bone Marrow Cells; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002877:Chromosomes, Human; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D002892:Chromosomes, Human, Pair 22; D002894:Chromosomes, Human, Pair 4; D002899:Chromosomes, Human, Pair 9; D005260:Female; D015321:Gene Rearrangement; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007223:Infant; D016256:Lewis X Antigen / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011123:Polyploidy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014178:Translocation, Genetic; D014312:Trisaccharides / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D007143:Immunoglobulin Heavy Chains; D016256:Lewis X Antigen; D011948:Receptors, Antigen, T-Cell; D014312:Trisaccharides