title: Local application of diminazene aceturate: an effective treatment for cutaneous leishmaniasis?
abstract: In a controlled clinical trial we tested the effect of diminazene aceturate (Berenyl, Bayer) in local application against cutaneous leishmaniasis. The study was performed among schoolchildren in Nyala, West-Sudan in 1988 during a major outbreak of cutaneous leishmaniasis in this region. Sixty-six schoolchildren with cutaneous leishmaniasis were enrolled in the study. The children were randomly assigned to either diminazene aceturate (Berenil) or cetrimide 15% + chlorhexidine 1.5% (Savlon) treatment. The study results show a significant faster healing of the ulcers in the children treated with diminazene aceturate (chi-square 7.31, p less than 0.01). We conclude that diminazene aceturate should be considered as a potential topical drug in the treatment of cutaneous leishmaniasis.
authors.forename: L
authors.initials: L
authors.lastname: Lynen
authors.forename: W
authors.initials: W
authors.lastname: Van Damme
mesh_terms: D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002593:Cetrimonium Compounds / Q000627:therapeutic use*; D002648:Child; D002710:Chlorhexidine / Q000627:therapeutic use; D004133:Diminazene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy*; D008297:Male
chemical_list: D000981:Antiprotozoal Agents; D002593:Cetrimonium Compounds; C003915:diminazene aceturate; D002710:Chlorhexidine; D004133:Diminazene