[A glycolytic marker test for individualizing the selection of chemical compounds for antitumor activity].
Based on literature data on effects of various preparations on the glycolysis in tumor and normal cells, a glycolytic molecular biochemical marker is proposed to screen chemical substances as potential antitumor drugs. A glycolytic specificity was noted in tumor cells which was regarded as a criterion for distinction of tumor cells from normal ones and among various histotypes of tumor cells as well as for the selective sensitivity of tumor cells to a substance. 17 of 38 substances tested were observed to inhibit glycolysis in tumor cells. The testing chemical substances for an antitumor activity with application of the glycolytic marker is recommended. A possibility is discussed of applying the marker for testing potential antitumor drugs, their individualization, and genetic typing.
Piruzian
L A
LA
Mikhaĭlovskiĭ
E M
EM
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006019:Glycolysis / Q000187:drug effects*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor
Glikoliznaia markernaia proba dlia individualizatsii otbora khimicheskikh soedineniĭ na protivoopukholevuiu aktivnost'.