title: The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese.
abstract: The relationship between the low Km aldehyde dehydrogenase (ALDH2) phenotype determined by the isoelectric focusing of hair root lysates, facial flushing and alcohol drinking patterns in Japanese (N = 282) was examined. Men who had inactive ALDH2 drank significantly less alcohol than those with active ALDH2. Although the effect was less noticeable, a similar relationship was detected in women. Two types of flushing responses were determined: one due to the inactive ALDH2, the other unrelated to this variant form of the isozyme. A striking difference between these flushing types, in terms of the inhibitory influence over drinking patterns, was noted. Nearly 86% of the subjects who reported always flushing in the face were shown to have inactive ALDH2, whereas infrequent flushing and absence of flushing were associated with active ALDH2. Thus, facial flushing may be used as an indicator of ALDH2 phenotype.
authors.affiliation: National Institute on Alcoholism, Kurihama National Hospital, Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
authors.forename: T
authors.initials: T
authors.lastname: Muramatsu
authors.forename: K
authors.initials: K
authors.lastname: Shigemori
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Kono
authors.forename: M C
authors.initials: MC
authors.lastname: Dufour
authors.forename: T C
authors.initials: TC
authors.lastname: Harford
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D000444:Aldehyde Dehydrogenase / Q000235:genetics* / Q000502:physiology; D003431:Cross-Cultural Comparison; D005260:Female; D005483:Flushing / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D006197:Hair / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000235:genetics* / Q000502:physiology; D007564:Japan; D008297:Male; D008875:Middle Aged; D010641:Phenotype
chemical_list: D007527:Isoenzymes; D000444:Aldehyde Dehydrogenase