Reversible hypophosphatemic rickets following ifosfamide treatment.
A 7-year-old boy developed renal tubular dysfunction and hypophosphatemic rickets following treatment for relapsed embryonal rhabdomyosarcoma. Multi-agent chemotherapy included ifosfamide; the child received a total of 108 g/m2. The complete Fanconi syndrome which ensued, including excessive loss of calcium, resolved spontaneously and progressively 18 months after the last dose of ifosfamide. The patient had no further symptoms of rickets and radiological signs had almost completely normalized. Further follow-up was not possible as, despite further treatment, the child died of progressive disease.
Van Gool
S
S
Department of Pediatrics, University Hospital, Gasthuisberg, Leuven, Belgium.
Brock
P
P
Wijndaele
G
G
Van de Casseye
W
W
Kruger
M
M
Proesmans
W
W
Casteels-Van Daele
M
M
D000008:Abdominal Neoplasms / Q000188:drug therapy; D002648:Child; D005198:Fanconi Syndrome / Q000139:chemically induced*; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D011859:Radiography; D012208:Rhabdomyosarcoma / Q000188:drug therapy; D014953:Wrist / Q000000981:diagnostic imaging
D007069:Ifosfamide