Altered mammary responsiveness to estradiol and progesterone in mice exposed neonatally to diethylstilbestrol.
Mammary glands from ovariectomised neonatally diethylstilbestrol (DES)-exposed (0.1 microgram daily for the first 5 days of life) mice seem morphologically indistinguishable from those of ovariectomised controls. However, administration of exogenous hormones reveals a differential response. In DES-exposed mice, estrogen implantation resulted in greater incidence of dilated ducts along with greater incidence of dilated ducts along with greater incidence and severity of terminal ductal hyperplasia and greater severity of cystic alveolar adenosis; combined estrogen and progestin treatment resulted in greater severity of terminal duct hyperplasia and less alveolar formation, and progestin treatment resulted in lower incidence and degree of lateral budding. Thus, mammary sensitivity to sex steroids is altered by early exposure of mice to DES.
Bern
H A
HA
Department of Integrative Biology, University of California, Berkeley 94720.
Mills
K T
KT
Hatch
D L
DL
Ostrander
P L
PL
Iguchi
T
T
D000818:Animals; D000831:Animals, Newborn; D003560:Cysts / Q000139:chemically induced / Q000473:pathology; D004054:Diethylstilbestrol / Q000633:toxicity*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006965:Hyperplasia; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology*
D011374:Progesterone; D004958:Estradiol; D004054:Diethylstilbestrol