Squamous carcinoma of oral tongue: prognostic significance of flow-cytometric DNA content.
Thirty-eight squamous carcinomas of the mobile tongue were flow cytometrically analyzed for their DNA content, and the results correlated with clinicopathologic parameters and patient survival. Tumor size (p = 0.01), depth of invasion (p = 0.05), histologic differentiation (p = 0.03), ploidy pattern (p = 0.01), and S-phase (p = 0.001) showed significant correlation with patients' clinical outcomes in univariate analyses. A multifactorial regression analysis of all significant parameters indicated that S-phase percentage and depth of tumor invasion were independent prognostic factors in this cohort.
Gomez
R
R
Department of Pathology, Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston.
el-Naggar
A K
AK
Byers
R M
RM
Garnsey
L
L
Luna
M A
MA
Batsakis
J G
JG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002455:Cell Division; D004247:DNA / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D011003:Ploidies; D011379:Prognosis; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
D004247:DNA