The effect of hyperosmolarity on muscle glycogen accumulation.
Soleus (red) and extensor digitorum longus (white) muscles from Sprague Dawley rats were incubated with 6-14C-labelled glucose in normal and in hyperosmotic media. Hyperosmolarity decreased 6-14C-glucose incorporation into muscle glycogen in a dose dependent manner and increased glycolysis and glucose oxidation. Increased glycogenolysis rather than decreased glycogenesis was responsible for the reduction in labelled glycogen accumulation.
Li
J
J
Department of Medicine, Medical College of Virginia, Richmond.
Stillman
J S
JS
Clore
J N
JN
Blackard
W G
WG
D000818:Animals; D006003:Glycogen / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D009132:Muscles / Q000378:metabolism*; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains
D006003:Glycogen