title: Reduced rate of uptake of zinc ions in a calf affected with the lethal syndrome A46 relative to clinically normal calves using whole body radio-isotope scanning of 62Zn.
abstract: Four clinically healthy control calves were scanned and blood clearance was determined from blood samples taken during the first hour after intravenous injection of 62Zn. Furthermore, one clinically healthy control calf and one calf suffering from the lethal hereditary syndrome A46 were scanned and blood samples taken from five min after intravenous and abomasal injection of 62Zn and onwards for a period of up to 26th. The results show a very fast liver uptake of 62Zn. The estimated rate of plasma/blood clearance and liver uptake for the control calves agrees with values derived from studies on other animals. In contrast, the A46 calf had a decreased rate of plasma/blood clearance and liver uptake relative to the control calves.
authors.affiliation: Department of Mathematics and Physics, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: R
authors.initials: R
authors.lastname: Bauer
authors.forename: E
authors.initials: E
authors.lastname: Brummerstedt
authors.forename: M
authors.initials: M
authors.lastname: Jensen
authors.forename: H
authors.initials: H
authors.lastname: Mejborn
authors.forename: M
authors.initials: M
authors.lastname: Smith
mesh_terms: D000818:Animals; D001692:Biological Transport; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000378:metabolism*; D007153:Immunologic Deficiency Syndromes / Q000378:metabolism / Q000662:veterinary*; D008657:Metabolic Clearance Rate; D011877:Radionuclide Imaging; D015032:Zinc / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics
chemical_list: D015032:Zinc