title: Prostate cancer presenting with malignant ascites: signet-ring cell variant of prostatic adenocarcinoma.
abstract: A case of prostate cancer presenting with malignant ascites as the sole clinical manifestation is reported. The clinical course simulated occult gastrointestinal malignancy. At the histologic level, the tumor had a signet-ring morphology. Detailed immunocytochemical and ultrastructural studies, however, confirmed the prostatic origin of this neoplasm. Signet-ring carcinoma of the prostate is a rare aggressive form of prostatic cancer which may present with a malignant effusion and may mimic gastrointestinal cancer.
authors.affiliation: Division of Radiation Oncology, Toronto Bayview Regional Cancer Centre, Canada.
authors.forename: P A
authors.initials: PA
authors.lastname: Catton
authors.forename: R W
authors.initials: RW
authors.lastname: Hartwick
authors.forename: J R
authors.initials: JR
authors.lastname: Srigley
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology* / Q000556:secondary; D001201:Ascites / Q000209:etiology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology*