title: Antimutagenicity of milk cultured with lactic acid bacteria against N-methyl-N'-nitro-N-nitrosoguanidine.
abstract: The antimutagenic effect of cultured milk using 71 strains of lactic acid bacteria belonging to the genus Lactobacillus, Streptococcus, Lactococcus, and Bifidobacterium on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine was investigated in vitro using Salmonella typhimurium TA 100 as an indicator bacterium. Each cultured milk sample displayed its characteristic antimutagenic effect on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. The milk cultured with Lactobacillus acidophilus LA 106 (LA2) showed the highest inhibition of 77% against the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine among the strains tested. Changes in the antimutagenic effect of the milk cultured by Lb. acidophilus LA 106 (LA2) during incubation were also examined using N-methyl-N'-nitro-N-nitrosoguanidine as a mutagen.
authors.affiliation: Technical Research Laboratory, Takanashi Milk Products Co., Ltd., Kanagawa-ken, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hosoda
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Chiba
authors.forename: A
authors.initials: A
authors.lastname: Hosono
mesh_terms: D000818:Animals; D001644:Bifidobacterium / Q000378:metabolism; D005285:Fermentation; D007778:Lactobacillus / Q000378:metabolism; D007779:Lactobacillus acidophilus / Q000378:metabolism*; D007780:Lacticaseibacillus casei / Q000378:metabolism; D017045:Lactococcus / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000037:antagonists & inhibitors*; D008892:Milk / Q000382:microbiology / Q000502:physiology*; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects; D013291:Streptococcus / Q000378:metabolism; D016985:Streptococcus bovis / Q000378:metabolism
chemical_list: D008769:Methylnitronitrosoguanidine