Bioactive polymers: in vitro and in vivo study of controlled release neomycin.
Neomycin is coupled on xanthan-a polysaccharide of microbial biosynthesis produced by Xanthomonas campestris-through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A controlled release of neomycin, following a zero order kinetics is observed, regardless of the eluent flow. Neomycin complexed on xanthan, administered in a unique daily dose to patients suffering from dysentery in the 100 cases taken in study, has shown a high clinical efficiency as compared with the treatments with ampicillin or furazolidone, administered for 5-10 days or longer.
Dumitriu
S
S
Polytechnic Institute of Jassy, Department of Macromolecular Chemistry, Romania.
Dumitriu
M
M
Dimitriu
S M
SM
Turcu
T
T
Grigore
L
L
Dumitriu
D
D
Iacob
M
M
D000328:Adult; D002648:Child; D003692:Delayed-Action Preparations; D003967:Diarrhea / Q000188:drug therapy / Q000382:microbiology; D004337:Drug Carriers; D004405:Dysentery, Bacillary / Q000188:drug therapy / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009355:Neomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011135:Polysaccharides, Bacterial; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology; D012486:Salmonella typhimurium; D012761:Shigella boydii; D012763:Shigella flexneri; D012764:Shigella sonnei; D013997:Time Factors
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011135:Polysaccharides, Bacterial; D009355:Neomycin; C002563:xanthan gum