Expression of c-jun and Egr-1 genes in rat liver in response to partial hepatectomy, and injection of turpentine.
In rat liver stimulated by partial hepatectomy a significant expression of Egr-1 and to less extent c-jun genes was observed within 15-30 min after the surgery. The induction is transient and vanishes within one hour. Egr-1 and c-jun were also induced in liver after subcutaneous injection of turpentine, a strong inducer of acute phase response. A maximum activation of these genes was observed within 4-9 hours after administration of turpentine. Both Egr-1 and c-jun extend the list of "immediate early" genes involved in proliferative response and constitute a group of genes inducible at the beginning of acute phase response.
Biesiada
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E
Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Krawczyk
Z
Z
Chorazy
M
M
D000210:Acute-Phase Reaction / Q000235:genetics*; D000818:Animals; D015152:Blotting, Northern; D002453:Cell Cycle / Q000235:genetics; D015342:DNA Probes; D015870:Gene Expression; D016758:Genes, jun / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000187:drug effects; D008115:Liver Regeneration / Q000235:genetics*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014425:Turpentine / Q000494:pharmacology*
D015342:DNA Probes; D014425:Turpentine