title: Cocaine, social behavior, and alcohol-solution drinking in monkeys.
abstract: Eight group-living male monkeys received cocaine (0 to 3.0 mg/kg) individually or as a group. Cocaine suppressed social affiliative behaviors, eating, and drinking (of both alcohol and control solutions). It induced bizarre stereotypies, hypervigilance, panic-like fleeing, enhancement and then suppression of locomotion, and a seizure. Cocaine had little effect on aggressiveness or sexual behavior. Proportion of time spent lying or sitting changed significantly. Cocaine produced severe behavioral abnormality in this social setting.
authors.affiliation: Department of Psychiatry, University of Colorado School of Medicine, Denver 80262.
authors.forename: T J
authors.initials: TJ
authors.lastname: Crowley
authors.forename: S K
authors.initials: SK
authors.lastname: Mikulich
authors.forename: E A
authors.initials: EA
authors.lastname: Williams
authors.forename: G O
authors.initials: GO
authors.lastname: Zerbe
authors.forename: N C
authors.initials: NC
authors.lastname: Ingersoll
mesh_terms: D000378:Agonistic Behavior / Q000187:drug effects; D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D006608:Hierarchy, Social; D007273:Injections, Intramuscular; D008251:Macaca; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012919:Social Behavior; D012931:Social Environment
chemical_list: D003042:Cocaine