Synthesis and activity of C-21 alkylamino derivatives of (9R)-erythromycylamine.
Novel analogs of (9R)-9-deoxo-9-(N,N-dimethylamino)erythromycin A bearing N-alkylamino substituents at the C-21 position were synthesized. These compounds retained antibacterial activity. The C-21, N,N-dimethylamino analog showed a modest improvement in activity against some Gram-negative bacteria.
Lartey
P A
PA
Abbott Laboratories, Abbott Park, IL 60064.
DeNinno
S L
SL
Faghih
R
R
Hardy
D J
DJ
Clement
J J
JJ
Plattner
J J
JJ
D001419:Bacteria / Q000187:drug effects; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
C007626:erythromyclamine; D004917:Erythromycin