title: Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication.
abstract: The aim of this study was to test the question of hyperhomocyst(e)inaemia as a risk factor for intermittent claudication (IC) independent of other important risk factors for peripheral atherosclerotic disease, such as smoking, hypertension, diabetes mellitus, hypercholesterolaemia, hypertriglyceridaemia, low levels of high-density-lipoprotein (HLD) cholesterol and age. The study population was recruited from an epidemiological study in Linköping County, Sweden, where all middle-aged men (n = 15,253, 45-69 years of age) were screened for IC. Seventy-eight subjects with verified IC and 98 healthy sex- and age-matched controls were randomly selected. Plasma levels of homocyst(e)ine (including the sum of free and bound forms of homocysteine and their disulphide oxidation products, homocystine, and homocysteine-cysteine mixed disulphide) were significantly higher (16.74 +/- 5.45 mumol l-1, mean value +/- SD, P = 0.0002) in IC subjects than in controls (13.80 +/- 3.21 mumol l-1), with 23% of the claudicants above the 95th percentile for controls. Stepwise logistic regression analysis revealed that the difference in plasma homocyst(e)ine was independent of the other above-mentioned risk factors. Moreover, the elevation of plasma homocyst(e)ine in claudicants was mainly confined to subjects with serum folate levels of less than or equal to 11.0 nmol l-1. The results suggest that folic acid supplementation should be tried in IC subjects with hyperhomocyst(e)inaemia.
authors.affiliation: Department of Internal Medicine, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Mölgaard
authors.forename: M R
authors.initials: MR
authors.lastname: Malinow
authors.forename: C
authors.initials: C
authors.lastname: Lassvik
authors.forename: A C
authors.initials: AC
authors.lastname: Holm
authors.forename: B
authors.initials: B
authors.lastname: Upson
authors.forename: A G
authors.initials: AG
authors.lastname: Olsson
mesh_terms: D000368:Aged; D005080:Exercise Test; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006711:Homocystine / Q000097:blood*; D006801:Humans; D007383:Intermittent Claudication / Q000097:blood*; D008055:Lipids / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D008055:Lipids; D006710:Homocysteine; D006711:Homocystine; D005492:Folic Acid