title: Prevention of appearance of radiological lesions in early rheumatoid arthritis: a randomized, single-blind study comparing intra-articular rifamycin with auranofin.
abstract: In a prospective, randomized, single-blind study of 116 patients with early rheumatoid arthritis (mean disease duration 7 months), therapeutic activity of intra-articular rifamycin SV (525 mg/week) infiltration into each peripheral joint over 10 weeks was compared with that of 3 mg auranofin given orally twice daily. The incidence of side-effects was lower in rifamycin-treated patients. At the end of follow-up, the clinical variables and erythrocyte sedimentation rate showed a significant and persistent improvement both in 16 patients who continued the auranofin treatment regularly and in 55 treated with rifamycin who had completed the therapeutic cycle 62.5 months before; the latex test decreased only in the rifamycin group. In patients treated with auranofin or who changed to other commonly used antirheumatic agents, 57% of those with an initially negative radiological picture developed new radiological lesions in at least one of the small joints compared with 9% in the rifamycin group. Although the number of patients treated with rifamycin was small and the follow-up relatively short, the results of the study indicated that treatment with intra-articular rifamycin SV may prevent the appearance of radiological lesions in patients with early rheumatoid arthritis and normal radiographs initially.
authors.affiliation: Rheumatology Unit, L. Sacco Hospital, Milan, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Caruso
authors.forename: S
authors.initials: S
authors.lastname: Santandrea
authors.forename: P
authors.initials: P
authors.lastname: Sarzi Puttini
authors.forename: F
authors.initials: F
authors.lastname: Montrone
authors.forename: L
authors.initials: L
authors.lastname: Boccassini
authors.forename: V
authors.initials: V
authors.lastname: Azzolini
authors.forename: M
authors.initials: M
authors.lastname: Cazzola
authors.forename: D
authors.initials: D
authors.lastname: Dell'Acqua
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001310:Auranofin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012294:Rifamycins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D012294:Rifamycins; D001310:Auranofin; C023808:rifamycin SV