title: Stress ulcers and organ failure in intubated patients in surgical intensive care units.
abstract: This study compared prophylactic administration of either intragastric misoprostol (200 micrograms four times a day), a prostaglandin E1 analog, or bolus intravenous cimetidine (300 mg every 6 hours) in preventing stress lesions and stress bleeding in 127 adult postoperative patients who required mechanical ventilation and also had developed hypotension or sepsis. Both drug treatments were equally effective in preventing the development of diffuse gastritis (greater than 10 gastric hemorrhagic lesions) and in preventing upper gastrointestinal hemorrhage (UGIH). The combined data from both groups showed that for the 44 (35%) patients who died, death was significantly associated with the presence at study entry of renal failure (64% of 25 patients with renal failure died), hepatic failure (57% of 23 patients) or coagulopathy (62% of 29 patients) (p less than 0.02 for each), and with the number of organ system failures at study entry (48% of 69 patients with multiple organ system failures died, p less than 0.001). Death was also significantly associated with the presence of adult respiratory distress syndrome (ARDS) at study entry or the development of ARDS (63% of 24 patients with ARDS died, p less than 0.001), and the development of UGIH (5% of 93 patients with known bleeding outcome died, p less than 0.05). The number of stress lesions that developed was significantly associated with subsequent UGIH (p less than 0.001). Additional organ system failure developed during the study in 31% of the 127 patients, as did diffuse gastritis in 20% of 111 patients who had a follow-up endoscopy. These results demonstrate that postoperative patients who require mechanical ventilation and have hypotension or sepsis are at significant risk for the development of stress gastric lesions and multiple organ system failure even when prophylaxis for stress ulcers is provided. Furthermore, the presence of ARDS, renal failure, hepatic failure, coagulopathy, and UGIH are significantly associated with death.
authors.affiliation: Department of Surgery, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033.
authors.forename: L F
authors.initials: LF
authors.lastname: Martin
authors.forename: F V
authors.initials: FV
authors.lastname: Booth
authors.forename: H D
authors.initials: HD
authors.lastname: Reines
authors.forename: L G
authors.initials: LG
authors.lastname: Deysach
authors.forename: R L
authors.initials: RL
authors.lastname: Kochman
authors.forename: L J
authors.initials: LJ
authors.lastname: Erhardt
authors.forename: G S
authors.initials: GS
authors.lastname: Geis
mesh_terms: D002423:Cause of Death; D002927:Cimetidine / Q000627:therapeutic use; D003422:Critical Care; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016595:Misoprostol / Q000627:therapeutic use; D009102:Multiple Organ Failure / Q000150:complications* / Q000517:prevention & control; D010437:Peptic Ulcer / Q000517:prevention & control*; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control*; D010919:Placebos; D011014:Pneumonia / Q000209:etiology; D011183:Postoperative Complications; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000150:complications; D013312:Stress, Physiological / Q000150:complications*; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D015996:Survival Rate; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D010919:Placebos; D016595:Misoprostol; D002927:Cimetidine