title: The lack of an effect of intraocular steroids on irradiated fibroblasts in experimental proliferative vitreoretinopathy.
abstract: Contraction of intraocular membranes is an important event in the development of proliferative vitreoretinopathy (PVR). When sufficient numbers of cells are present in the vitreous cavity, the retina usually detaches as a result of the contractive force generated by these cells. Steroids reduce the occurrence of retinal detachments in rabbit models of PVR by inhibiting the proliferation of injected fibroblasts. In this study, we used non-proliferative, irradiated cells to determine a possible effect of steroids on preretinal membrane contraction in PVR. We found no clinical difference between steroid treated eyes and sham-treated control eyes. Surgical reduction of the contractile tissue and medical therapy to prevent reproliferation are necessary in order to treat PVR effectively.
authors.affiliation: Department of Ophthalmology, Duke University Eye Center, Durham, NC 27710.
authors.forename: D B
authors.initials: DB
authors.lastname: Chandler
authors.forename: T
authors.initials: T
authors.lastname: Hida
authors.forename: G
authors.initials: G
authors.lastname: Rozakis
authors.forename: V S
authors.initials: VS
authors.lastname: Forbes
authors.forename: R
authors.initials: R
authors.lastname: Machemer
mesh_terms: D000818:Animals; D002588:Cesium Radioisotopes; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000188:drug therapy*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects*; D007267:Injections; D008297:Male; D011817:Rabbits; D012163:Retinal Detachment / Q000188:drug therapy; D012164:Retinal Diseases / Q000188:drug therapy*; D014222:Triamcinolone Acetonide / Q000494:pharmacology*; D014822:Vitreous Body / Q000473:pathology
chemical_list: D002588:Cesium Radioisotopes; D014222:Triamcinolone Acetonide