[The respiratory activity of the liver mitochondria and the viability of rat pups subjected to changes in their carbohydrate metabolism in the prenatal development period].
It is shown that hyperglycemia after insulin introduction to the pregnant rats delays oxidation of pyruvate and malate by liver mitochondria as well as decreases offspring vitality. Digestive hyperglycemia activates utilization of this intermediate by liver mitochondria, that increases the rat vitality.
Makhmudov
E S
ES
Akhmerov
R N
RN
Babaeva
R N
RN
Kim
N P
NP
D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006943:Hyperglycemia / Q000503:physiopathology; D007328:Insulin / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats
D004040:Dietary Carbohydrates; D007328:Insulin; D005947:Glucose
Dykhatel'naia aktivnost' mitokhondriĭ pecheni i zhiznesposobnost' krysiat, podvergnutykh izmeneniiami ikh uglevodnogo obmena v prenatal'nyĭ period razvitiia.