title: Squamous carcinoma of oral tongue: prognostic significance of flow-cytometric DNA content.
abstract: Thirty-eight squamous carcinomas of the mobile tongue were flow cytometrically analyzed for their DNA content, and the results correlated with clinicopathologic parameters and patient survival. Tumor size (p = 0.01), depth of invasion (p = 0.05), histologic differentiation (p = 0.03), ploidy pattern (p = 0.01), and S-phase (p = 0.001) showed significant correlation with patients' clinical outcomes in univariate analyses. A multifactorial regression analysis of all significant parameters indicated that S-phase percentage and depth of tumor invasion were independent prognostic factors in this cohort.
authors.affiliation: Department of Pathology, Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston.
authors.forename: R
authors.initials: R
authors.lastname: Gomez
authors.forename: A K
authors.initials: AK
authors.lastname: el-Naggar
authors.forename: R M
authors.initials: RM
authors.lastname: Byers
authors.forename: L
authors.initials: L
authors.lastname: Garnsey
authors.forename: M A
authors.initials: MA
authors.lastname: Luna
authors.forename: J G
authors.initials: JG
authors.lastname: Batsakis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002455:Cell Division; D004247:DNA / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D011003:Ploidies; D011379:Prognosis; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology
chemical_list: D004247:DNA