Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.
Exposure of rat portal veins to an N2-gassed buffer markedly increased 86Rb outflow. Moreover, glucose caused a pronounced reduction in 86Rb outflow from portal veins perfused with an N2-gassed buffer. Pinacidil, cromakalim and diazoxide provoked a sustained increase in 86Rb outflow. The stimulatory effect of pinacidil was not impaired in the absence of extracellular Ca2+ but was completely abolished by glibenclamide. These observations are compatible with the involvement of a metabolic process in the control of the K+ permeability, namely with the existence in rat portal veins of ATP-sensitive K+ channels.
Antoine
M H
MH
Laboratory of Pharmacology, Faculty of Medicine, Brussels Free University, Belgium.
Herchuelz
A
A
Lebrun
P
P
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D019806:Cromakalim; D003981:Diazoxide / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006146:Guanidines / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism*; D010539:Permeability / Q000187:drug effects; D020110:Pinacidil; D011169:Portal Vein / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D011758:Pyrroles / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012414:Rubidium Radioisotopes
D001578:Benzopyrans; D006146:Guanidines; D015221:Potassium Channels; D011758:Pyrroles; D012414:Rubidium Radioisotopes; D019806:Cromakalim; D020110:Pinacidil; D000255:Adenosine Triphosphate; D005947:Glucose; D003981:Diazoxide; D011188:Potassium