Mapping of the human GSPT1 gene, a human homolog of the yeast GST1 gene, to chromosomal band 16p13.1.
The GSPT1 gene, a human homolog of the yeast GST1 gene (formerly named GST1-Hs), was mapped on human chromosome 16p13.1 by a combination of nonradioactive in situ hybridization and Giemsa staining. Southern blot hybridization with a panel of human-rodent somatic cells confirmed the location of the GSPT1 gene on chromosome 16 and also showed the existence of a homologous gene on the X chromosome. A breakpoint for nonrandom chromosome rearrangements has been found in the region of GSPT1 in patients with acute nonlymphocytic leukemia.
Ozawa
K
K
Gene Bank, Riken Institute, Ibaraki, Japan.
Murakami
Y
Y
Eki
T
T
Yokoyama
K
K
Soeda
E
E
Hoshino
S
S
Ui
M
M
Hanaoka
F
F
D015139:Blotting, Southern; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid; D014960:X Chromosome
D005982:Glutathione Transferase