Evaluation of serum levels of soluble interleukin-2 receptor as an indicator of disease activity in systemic lupus erythematosus.
Serum levels of the soluble form of the interleukin-2 receptor (sIL-2R) were measured in the sera of 32 patients with systemic lupus erythematosus. A significant correlation was observed between the levels of sIL-2R and the SLAM score of disease activity (R:0.40; p: less than 0.05). The correlation was slightly lower than those between the SLAM score and the levels of anti-dsDNA or of the complement activity. The levels of sIL-2R were not significantly correlated with those of serum anti-ds-DNA and complement, nor with a sign of peripheral blood B cell hyperactivity, such as the spontaneous in vitro production of anti-DNA antibodies.
Airŏ
P
P
Servizio di Immunologia Clinica, Spedali Civili, Brescia, Italy.
Braga
S
S
Prati
E
E
Brugnoni
D
D
Bettinzioli
M
M
Gorla
R
R
Cattaneo
R
R
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012720:Severity of Illness Index
D000974:Antibodies, Antinuclear; D015375:Receptors, Interleukin-2