title: The role of surgery in abdominal non-Hodgkin's lymphoma: experience from the Childrens Cancer Study Group.
abstract: To determine the appropriate role of surgical intervention in non-Hodgkin's lymphoma primary to the abdomen, we analyzed the effect of multiple prognostic determinants on event-free survival for patients entered into the CCG-551 study. Eighty-four patients were identified with abdominal lymphoma and of these adequate data for analysis was available on 68 (81%). Variables of interest included: extent of disease at diagnosis, completeness of resection, use of bowel resection, radiation to the primary site, and sex/age/race. The median age on study was 8 years; 79% of patients were white and 85% were male. Thirty-three patients (49%) presented with localized disease. Laparotomy was performed in 67 children (99%) with complete gross resection in 28 (42%). Of the 10 reported surgical complications, 8 occurred in those with extensive disease who were incompletely resected. Radiation to the primary site was given in 60% of patients with median dose of 2,000 cGy. Analysis was performed both for the overall group and for the subgroup receiving optimal chemotherapy for histopathology. Variables with significant predictive effect on event-free survival in univariate analysis included extent of disease (P less than or equal to .001), complete resection (P less than or equal to .002), and use of bowel resection (P less than or equal to .004). However, in multivariate analysis, only extent of disease was an independent predictor of outcome. The data support a role for complete operative excision of localized lymphomas especially when accomplished with bowel resection. Aggressive attempts at debulking extensive retroperitoneal or mesenteric lymphomas are contraindicated.
authors.affiliation: Lymphoma Strategy Group, Childrens Cancer Study Group, Arcadia, CA.
authors.forename: M P
authors.initials: MP
authors.lastname: LaQuaglia
authors.forename: C J
authors.initials: CJ
authors.lastname: Stolar
authors.forename: M
authors.initials: M
authors.lastname: Krailo
authors.forename: P
authors.initials: P
authors.lastname: Exelby
authors.forename: S
authors.initials: S
authors.lastname: Siegel
authors.forename: A
authors.initials: A
authors.lastname: Meadows
authors.forename: D
authors.initials: D
authors.lastname: Hammond
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007414:Intestinal Neoplasms / Q000473:pathology / Q000601:surgery; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications; D011336:Probability; D012086:Reoperation; D015996:Survival Rate; D016896:Treatment Outcome