title: Dose response and duration of action of dorzolamide, a topical carbonic anhydrase inhibitor.
abstract: The multiple-dose, dose-response relationship and duration of action of the novel topical carbonic anhydrase inhibitor dorzolamide (previously known as MK-507) were investigated in a double-masked, randomized, placebo-controlled, parallel study in 73 patients with bilateral primary open angle glaucoma or ocular hypertension. Dorzolamide (0.7%, 1.4%, or 2%) or placebo was administered every 12 hours for 5 days and then every 8 hours for 7 days. Intraocular pressure was investigated with multiple 12-hour diurnal curves. All concentrations of dorzolamide demonstrated substantial lowering of intraocular pressure throughout the day when given twice daily (9% to 21%) or three times daily (14% to 24%). Although a dose-dependent response was observed immediately following the first dose, there were no significant differences between concentrations or dose response at either the twice or three times daily dosing regimen. Three times daily administration of 2% dorzolamide demonstrated a mean percent decrease in intraocular pressure of 18% to 22% throughout the day (mean decrease, 4.5 to 6.1 mm Hg). Dorzolamide appears to have substantial potential in the treatment of glaucoma and ocular hypertension.
authors.affiliation: Clinical Research, Merck Sharp & Dohme Research Laboratories, West Point, Pa. 19486.
authors.forename: E A
authors.initials: EA
authors.lastname: Lippa
authors.forename: L E
authors.initials: LE
authors.lastname: Carlson
authors.forename: B
authors.initials: B
authors.lastname: Ehinger
authors.forename: L O
authors.initials: LO
authors.lastname: Eriksson
authors.forename: K
authors.initials: K
authors.lastname: Finnström
authors.forename: C
authors.initials: C
authors.lastname: Holmin
authors.forename: S E
authors.initials: SE
authors.lastname: Nilsson
authors.forename: K
authors.initials: K
authors.lastname: Nyman
authors.forename: C
authors.initials: C
authors.lastname: Raitta
authors.forename: A
authors.initials: A
authors.lastname: Ringvold
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy*; D010919:Placebos; D013449:Sulfonamides / Q000008:administration & dosage* / Q000627:therapeutic use; D013876:Thiophenes / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D010919:Placebos; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide