Drug use in the newborn. Effects on the kidney.
In the neonate, there are a number of age-related differences in drug disposition (bioavailability, distribution, metabolism, and excretion), and these are directly related to the degree of prematurity. This article discusses the use of drugs that are commonly administered to the neonatal patient, with special emphasis given to renal considerations. These drugs include diuretics, theophylline, converting enzyme inhibitors, calcium channel blockers, indomethacin, and dopamine.
Wahlig
T M
TM
Division of Neonatology, University of Minnesota Medical School, Minneapolis.
Thompson
T R
TR
Sinaiko
A R
AR
D000959:Antihypertensive Agents / Q000494:pharmacology; D004232:Diuretics / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D004358:Drug Therapy / Q000592:standards*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007231:Infant, Newborn; D007668:Kidney / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology
D000959:Antihypertensive Agents; D004232:Diuretics; D013806:Theophylline; D004298:Dopamine; D007213:Indomethacin