The iridocyclitis of early onset pauciarticular juvenile rheumatoid arthritis: outcome in immunogenetically characterized patients.
In a cohort of 72 patients with iridocyclitis (iritis) and early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) the course of the eye disease was matched with ocular outcome. Chronicity of inflammation (greater than 6 months/episode) was correlated with complications of eye disease that caused impairment of vision. HLA antigens in these patients were compared with the HLA antigens in a cohort of 77 patients with EOPA-JRA in whom iridocyclitis had failed to develop over a followup of 5 years or longer. HLA-DR5 (11) was correlated with the presence of eye disease, and HLA-DR1 with its absence; HLA-DRw8, which strongly predisposes to EOPA-JRA, was neutral with respect to eye disease.
Malagon
C
C
Children's Hospital Medical Center, Cincinnati, OH 45229-2899.
Van Kerckhove
C
C
Giannini
E H
EH
Taylor
J
J
Lovell
D J
DJ
Levinson
J E
JE
Passo
M H
MH
Ginsberg
J
J
Burke
M J
MJ
Glass
D N
DN
D001171:Arthritis, Juvenile / Q000150:complications* / Q000235:genetics / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D005796:Genes; D006681:HLA-D Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D007125:Immunogenetics; D015863:Iridocyclitis / Q000209:etiology* / Q000503:physiopathology; D008297:Male
D006681:HLA-D Antigens