title: Interruptions adversely affect local control and survival with hyperfractionated radiation therapy of carcinomas of the upper respiratory and digestive tracts. New evidence for accelerated proliferation from Radiation Therapy Oncology Group Protocol 8313.
abstract: Hyperfractionated radiation therapy (HFX) attempts to overcome tumor proliferation during treatment by permitting higher total doses in the same overall time as standard fractionation. Whereas interruptions, including splits, reduce local control with standard fractionation in carcinoma of the upper respiratory and digestive tracts, HFX might compensate for interruptions. Patients were randomized to receive total doses of 6720, 7200, 7680, and 8160 cGy, using 120 cGy twice daily, 5 days per week. Those analyzed received +/- 4% of assigned total dose and lived 90 days or more. Treatment was completed within 5 days of the time specified for each treatment arm in 233 patients; 48, 80, and 131 patients had delays 14, 10, and 5 days or more, respectively. Locoregional control and survival were significantly (P less than or equal to 0.03) reduced with delays of 5 days or more when corrected for prognostic factors. Late effects of radiation therapy were not affected by interruptions. These data support the hypothesis that proliferation (possibly accelerated) of tumor clonogens during treatment influences the outcome.
authors.affiliation: University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: J D
authors.initials: JD
authors.lastname: Cox
authors.forename: T F
authors.initials: TF
authors.lastname: Pajak
authors.forename: V A
authors.initials: VA
authors.lastname: Marcial
authors.forename: L
authors.initials: L
authors.lastname: Coia
authors.forename: M
authors.initials: M
authors.lastname: Mohiuddin
authors.forename: K K
authors.initials: KK
authors.lastname: Fu
authors.forename: H M
authors.initials: HM
authors.lastname: Selim
authors.forename: R W
authors.initials: RW
authors.lastname: Byhardt
authors.forename: P
authors.initials: P
authors.lastname: Rubin
authors.forename: H G
authors.initials: HG
authors.lastname: Ortiz
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002470:Cell Survival; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D010610:Pharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage / Q000592:standards*; D016019:Survival Analysis; D013997:Time Factors