A novel homoisocarbacyclin analog with potent and long-lasting activity.
A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3), has been accomplished. The analog (3), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities.
Shibasaki
M
M
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Takahashi
A
A
Aoki
T
T
Sato
H
H
Yamada
S
S
Kudo
M
M
Kogi
K
K
Narita
S
S
D000818:Animals; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits
D010975:Platelet Aggregation Inhibitors; C074379:TY 11223; D011464:Epoprostenol