Pregnancy rates in beef cattle after administering a GnRH agonist 11 to 14 days after insemination.
The objective of our study was to determine the dose-pregnancy rate response of a GnRH agonist injected once during the luteal phase in virgin heifers (four locations) and suckled beef cows (two locations) during the spring of 1989. The same treatments in virgin heifers were used at one location in the fall of 1989. Heifers and cows were inseminated at a synchronized estrus and then assigned randomly to each of three doses (0, 100, or 200 micrograms) of fertirelin acetate administered in 4 ml of saline in a double-blind study after being blocked by inseminator and service sire. Injections were given (i.m.) once on d 11, 12, 13, or 14 after estrus. Pregnancy rates were determined by palpation of the uterus per rectum and(or) by actual calving dates. Overall pregnancy rates for heifers across five locations were 86/201 (43%), 100/197 (51%), and 100/203 (49%) for the 0, 100, and 200 micrograms doses of fertirelin acetate, respectively. Pregnancy rates for heifers at two locations based on calving data were 28/48 (50%), 31/47 (66%), and 34/52 (65%) for the three doses. Both the 100- and 200-micrograms doses increased (P less than .05) pregnancy rates in heifers based on palpation results, whereas only the 200-micrograms dose tended to increase (P = .10) pregnancy rates based on calving results. Pregnancy rates based on palpation for suckled beef cows at two locations were 36/51 (71%), 30/43 (70%), and 34/51 (67%), and the corresponding pregnancy rates based on calving results were 30/41 (73%), 32/36 (89%), and 31/38 (82%) for the 0, 100, and 200 micrograms doses, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Rettmer
I
I
Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201.
Stevenson
J S
JS
Corah
L R
LR
D000818:Animals; D002417:Cattle / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004971:Estrus / Q000187:drug effects; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006728:Hormones / Q000008:administration & dosage / Q000494:pharmacology; D007315:Insemination, Artificial / Q000662:veterinary*; D008183:Luteal Phase; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011897:Random Allocation
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; C009936:fertirelin