Intermediate filament dynamics.
The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place. This incorporation appears to be required for maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational level, phosphorylation is an important factor in regulating dynamic aspects of intermediate filament organization and structure.
Eriksson
J E
JE
Department of Cell, Molecular and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611-3008.
Opal
P
P
Goldman
R D
RD
D000818:Animals; D007381:Intermediate Filament Proteins / Q000378:metabolism; D007382:Intermediate Filaments / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation
D007381:Intermediate Filament Proteins