Mode of interaction of 5-fluorouracil, radiation, and mitomycin C: in vitro studies.
An examination of the effects of radiation combined with either 5-fluorouracil, Mitomycin C, or both drugs in vitro has been made using a mouse squamous tumor cell line SCC VIITo and cell viability as an endpoint. Depending on how the survival endpoint was calculated, the interaction of 5-fluorouracil, Mitomycin C, or 5-fluorouracil plus Mitomycin C with radiation was greater than additive (plating efficiency) or only additive (viable cells per flask). These results suggest that the cytostatic effect of these drugs may be an important aspect of their action clinically.
Dobrowsky
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Division of Experimental Therapeutics, Ontario Cancer Institute, Toronto, Canada.
Dobrowsky
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Rauth
A M
AM
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005472:Fluorouracil / Q000494:pharmacology*; D066298:In Vitro Techniques; D051379:Mice; D016685:Mitomycin / Q000494:pharmacology*; D011836:Radiation Tolerance / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000528:radiation effects*
D016685:Mitomycin; D005472:Fluorouracil