Fertility rates with delayed fibrin glue: vasovasostomy in rats.
OBJECTIVE
To determine if fibrin glued vasovasostomy had comparable fertility rates to sutured vasovasostomy.


METHODS
Twenty adult male Sprague-Dawley rats underwent bilateral vasectomy. Two weeks after vasectomy, 10 rats had a bilateral sutured vasal anastomosis consisting of four mucosal and four seromuscular sutures with 10-0 nylon. The second group of 10 rats underwent bilateral fibrin glue vasal anastomosis consisting of two transmural sutures with 10-0 nylon followed by application of fibrin glue. One month after vasectomy reversal, each male rat was mated with a female rat for a period of 2 weeks.


METHODS
Animal laboratory. PATIENTS PARTICIPANTS: Twenty male Sprague-Dawley rats.


METHODS
Bilateral vasectomies in 20 male Sprague-Dawley rats. Two weeks after vasectomy, 10 rats had bilateral sutured vasal anastomosis, and 10 rats had bilateral glued vasal anastomosis.


METHODS
Pregnancy after vasectomy reversal.


RESULTS
Ten of 10 rats in the sutured group produced offspring for a fertility rate of 100%. Eight of 10 rats in the fibrin glue group produced offspring for a fertility rate of 80%. There was no statistically significant difference in the pregnancy rates between the two groups at the 95% confidence interval.


CONCLUSIONS
Fibrin glue-delayed vasectomy reversal produces comparable fertility rates compared with conventional sutured vasectomy reversal in the rat.
Weiss
J N
JN
Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York.
Mellinger
B C
BC
D000269:Adhesives; D000818:Animals; D005260:Female; D005298:Fertility; D005337:Fibrin; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000502:physiology / Q000601:surgery*; D014659:Vasectomy
D000269:Adhesives; D005337:Fibrin