title: Expression of adult T-cell leukaemia-derived factor, a human thioredoxin homologue, in the human ovary throughout the menstrual cycle.
abstract: An immunohistochemical study of the expression of adult T-cell leukaemia-derived factor (ADF), a human thioredoxin homologue, was performed in the normal human ovary throughout the menstrual cycle. Primordial follicles were negative for ADF. Both granulosa cells and theca interna cells at the stages of preantral and antral follicles contained ADF. The staining intensity of these cells was very strong in the preovulatory dominant follicle. After ovulation, both granulo-lutein and theca-lutein cells were positive for ADF. During pregnancy, the theca-lutein cells revealed very intense ADF staining. The theca interna cells of the atretic follicles showed ADF staining, while the granulosa cells of such follicles did not. These results suggest that ADF localizes in the ovarian steroidogenic cells which have the binding sites of either luteinizing hormone or follicle-stimulating hormone, and that ADF expression is closely associated with the activity of the ovarian steroidogenic cells.
authors.affiliation: Department of Gynaecology and Obstetrics, Faculty of Medicine, Kyoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwai
authors.forename: S
authors.initials: S
authors.lastname: Fujii
authors.forename: Y
authors.initials: Y
authors.lastname: Nanbu
authors.forename: H
authors.initials: H
authors.lastname: Nonogaki
authors.forename: I
authors.initials: I
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Masutani
authors.forename: J
authors.initials: J
authors.lastname: Yodoi
mesh_terms: D000328:Adult; D003338:Corpus Luteum / Q000166:cytology / Q000473:pathology / Q000502:physiology; D016207:Cytokines; D005260:Female; D005496:Follicular Atresia; D006107:Granulosa Cells / Q000166:cytology / Q000473:pathology / Q000502:physiology; D006801:Humans; D008597:Menstrual Cycle; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D010053:Ovary / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D011247:Pregnancy; D013799:Theca Cells / Q000166:cytology / Q000473:pathology / Q000502:physiology; D013879:Thioredoxins / Q000032:analysis
chemical_list: D016207:Cytokines; D009363:Neoplasm Proteins; C055533:adult T cell leukemia-derived factor; D013879:Thioredoxins