title: Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
abstract: We found deletions of both alleles of the retinoblastoma gene (Rb) and the candidate Wilms' tumor gene (WT33) in a surgically resected human insulinoma by blot hybridization. Rearrangement of Krev-1, a transformation suppressor gene, was also detected in this case. The clinical and histological findings suggested that this tumor would be a benign insulinoma. The result suggests that the inactivation of multiple tumor suppressor genes could be involved even in the development of benign human tumors.
authors.affiliation: Department of Microbiology, University of Tsukuba.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamura
authors.forename: T
authors.initials: T
authors.lastname: Futagawa
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D005260:Female; D015321:Gene Rearrangement; D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor; D016162:Genes, Wilms Tumor; D006801:Humans; D007340:Insulinoma / Q000235:genetics*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics*