title: Proliferative responses of lymphocytes to mitogens in the gray, short-tailed opossum, Monodelphis domestica.
abstract: A South American opossum (Monodelphis domestica) is a model animal for studies on the health effects of exposure to ultraviolet radiation (UVR). As part of a broad evaluation of immune function in this animal, we have tested in vitro mitogenic responses using whole blood cultures. Lymphocytes proliferated in the presence of phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM), but were unresponsive to bacterial lipopolysaccharide (LPS).
authors.affiliation: Photomedicine Program, Lovelace Medical Foundation, Albuquerque, NM 87108.
authors.forename: C M
authors.initials: CM
authors.lastname: Brozek
authors.forename: E W
authors.initials: EW
authors.lastname: Kaleta
authors.forename: D F
authors.initials: DF
authors.lastname: Kusewitt
authors.forename: R D
authors.initials: RD
authors.lastname: Ley
mesh_terms: D000818:Animals; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008934:Mitogens / Q000276:immunology*; D009893:Opossums / Q000276:immunology*
chemical_list: D008934:Mitogens