title: The arthritis of ulcerative colitis: clinical and genetic aspects.
abstract: Seventy-nine consecutive patients with active ulcerative colitis were studied to establish the prevalence and clinical features of articular involvement. HLA typing for A and B loci was performed. Forty-nine patients showed an articular involvement (62%). Three different clinical patterns were identified: ankylosing spondylitis occurring in 20 subjects; peripheral arthritis in 15; unclassifiable spondylitis in 14. When compared to the general population in our area, patients with colitis showed a significantly higher prevalence of the HLA-A1 (p less than 0.005), B21 (p less than 0.001) and B27 (p less than 0.05); among patients with colitis, those with arthritis revealed higher frequency of HLA-B27 (p less than 0.05). Our study reveals a high prevalence of unclassifiable spondylitis during ulcerative colitis, and suggests a new approach to the classification of seronegative spondarthritis.
authors.affiliation: Department of Internal Medicine, 2nd Medical School, University of Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Scarpa
authors.forename: A
authors.initials: A
authors.lastname: del Puente
authors.forename: A
authors.initials: A
authors.lastname: D'Arienzo
authors.forename: C
authors.initials: C
authors.lastname: di Girolamo
authors.forename: G
authors.initials: G
authors.lastname: della Valle
authors.forename: A
authors.initials: A
authors.lastname: Panarese
authors.forename: E
authors.initials: E
authors.lastname: Lubrano
authors.forename: P
authors.initials: P
authors.lastname: Oriente
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000453:epidemiology / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000235:genetics / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000145:classification; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013166:Spondylitis / Q000209:etiology; D013167:Spondylitis, Ankylosing / Q000209:etiology
chemical_list: D006680:HLA Antigens