[Does silicone induce autoimmune diseases? Review of the literature and case reports].
Silicone is able to induce different immunological reactions: Local foreign body reactions with activation of fibroblasts, granuloma formation and clinical manifestation of autoimmune diseases may occur. We report 4 cases with possible autoimmune disease in connection with breast augmentation. In one case explantation lead to both clinical and serological improvement with a decrease of antinuclear antibodies from 1:1280 to 1:160. In addition we report the spectrum of silicone induced systemic side effects and discuss the possible cellular reactions as well as the immunological changes.
Kaiser
W
W
II. Medizinische Abteilung, Allgemeines Krankenhaus Linz, Osterreich.
Zazgornik
J
J
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000139:chemically induced; D001327:Autoimmune Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D016462:Mammaplasty; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced*; D019736:Prostheses and Implants; D012307:Risk Factors; D012828:Silicones / Q000009:adverse effects*
D012828:Silicones
Führt Silikon zu Autoimmunerkrankungen? Literaturübersicht und Fallberichte.