title: del(6q) as a possible primary change in malignant mesothelioma.
abstract: Detailed cytogenetic and fluorescence in situ hybridization analysis of an untreated pleural malignant mesothelioma revealed two clonal cell populations, both with a single abnormality affecting chromosome 6. The majority of cells had a deletion together with an inversion of the long arm of chromosome 6, while a smaller population showed loss of this chromosome. The normal 6 was retained. Most reports show that mesotheliomas are characterized by complex karyotypes, involving numerous chromosomes. Abnormalities of chromosome 6 (particularly deletions of the long arm) are among the consistent changes. Our case apparently is the first report of a mesothelioma with a single change involving chromosome 6, which could be the primary cytogenetic change.
authors.affiliation: Cancer Center of Genetrix, Inc., Scottsdale, Arizona 85251.
authors.forename: A M
authors.initials: AM
authors.lastname: Meloni
authors.forename: C F
authors.initials: CF
authors.lastname: Stephenson
authors.forename: F P
authors.initials: FP
authors.lastname: Li
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping; D008654:Mesothelioma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008957:Models, Genetic; D009693:Nucleic Acid Hybridization; D010997:Pleural Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery