title: [Idiopathic hypercalciuria and bone density].
abstract: A decrease in bone density of the spine has been reported in individuals with hypercalciuria and the finding of the latter in osteoporosis patients is not uncommon. We studied 21 men and 8 women (mean age 47 +/- 13) with idiopathic hypercalciuria (IHCU) defined by an urinary calcium of more than 7.5 mmol/24 h in men and 6.25 mmol/24 h in women. The duration of IHCU was 10 (+/-) 8 years. Among the 29 patients, 24 had one or more renal calculi. Twenty one had been treated, by low calcium diet only (and diuresis), combined with a thiazide diuretic, or sodium phytate, or phosphorus. Bone mineral content (BMC) was measured in the lumbar spine and the upper end of the femur using an ORIS ODC 200 densitometer and compared with 29 control subjects paired for age and sex. No difference was found between the two groups concerning BMC values in either the spine or the 3 femoral sites (neck, Ward, trochanter). BMC was not correlated with urinary calcium. Thus individuals with IHCU showed no decrease in their bone mass, among this group seen in a department of nephrology. The influence of the treatment of IHCU remains to be defined.
authors.affiliation: Service de Rhumatologie, Hôpital de Boisguillaume, CHU de Rouen.
authors.forename: A
authors.initials: A
authors.lastname: Daragon
authors.forename: M
authors.initials: M
authors.lastname: Dhib
authors.forename: J P
authors.initials: JP
authors.lastname: Morin
authors.forename: M
authors.initials: M
authors.lastname: Godin
authors.forename: J P
authors.initials: JP
authors.lastname: Fillastre
mesh_terms: D000328:Adult; D015519:Bone Density / Q000502:physiology*; D002118:Calcium / Q000652:urine*; D002128:Calcium Metabolism Disorders / Q000503:physiopathology*; D005260:Female; D005270:Femur Head / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D013131:Spine / Q000503:physiopathology
chemical_list: D002118:Calcium
vernacular_title: Hypercalciurie idiopathique et densité osseuse.