Inhibition of polyketide synthesis in Alternaria alternata by the fatty acid synthesis inhibitor cerulenin.
The fatty acid synthase inhibitor cerulenin (50 to 100 micrograms/ml) inhibited production of the polyketide mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) by the mold Alternaria alternata. The results suggested that AOH synthesis was inhibited by a direct mechanism by cerulenin, whereas production of AME was probably limited by a shortage of the precursor AOH.
Hiltunen
M
M
Department of Physiological Botany, University of Uppsala, Sweden.
Söderhäll
K
K
D000528:Alternaria / Q000187:drug effects* / Q000378:metabolism; D002569:Cerulenin / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis; D007783:Lactones / Q000378:metabolism*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors*
D005227:Fatty Acids; D007783:Lactones; D009097:Multienzyme Complexes; D002569:Cerulenin; C005197:alternariol; C018206:alternariol monomethyl ether