title: Accelerated endocytosis and incomplete catabolism of radical-damaged protein.
abstract: Native bovine serum albumin (BSA) was endocytosed and degraded at a steady rate by resident peritoneal murine macrophages with barely detectable amounts remaining within the cells. Radical-damaged BSA was endocytosed and degraded up to 2.5-fold more rapidly than native BSA, but some radical-damaged BSA accumulated within the cells in a time-dependent manner. The extent of accumulation increased in parallel with that of radical damage. Thus, some radical-damaged BSA was processed less efficiently than native BSA. Such inefficient catabolism of radical-damaged proteins may contribute to certain diseases such as atherosclerosis.
authors.affiliation: Heart Research Institute, Camperdown, Sydney, Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Grant
authors.forename: W
authors.initials: W
authors.lastname: Jessup
authors.forename: R T
authors.initials: RT
authors.lastname: Dean
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004586:Electrophoresis; D004705:Endocytosis / Q000502:physiology*; D005609:Free Radicals / Q000378:metabolism; D006207:Half-Life; D006868:Hydrolysis; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D012710:Serum Albumin, Bovine