title: Intramedullary fixation of cortical bone osteotomies with self-reinforced polylactic rods in rabbits.
abstract: Osteotomies of the femoral shaft in rabbits were fixed with intramedullary rods made of poly-L-lactic acid (SR-PLLA) and poly-DL/L-lactic acid (SR-PDLLA/PLLA). Follow up was from one week to 2 years. In the PLLA group, in 37 out of 40 osteotomies the fixation was firm and the bone was united. In the PDLLA/PLLA group, the fixation was firm in 30 out of 45, but in 13 of these angular deformity of more than 10 degrees had occurred. The fixation had failed in 15. No inflammatory or foreign body reaction was seen in either group. This study demonstrates that SR-PLLA rods are suitable fixation for cortical osteotomies in rabbits.
authors.affiliation: Department of Orthopaedics and Traumatology, University Central Hospital, Helsinki, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Majola
authors.forename: S
authors.initials: S
authors.lastname: Vainionpää
authors.forename: K
authors.initials: K
authors.lastname: Vihtonen
authors.forename: J
authors.initials: J
authors.lastname: Vasenius
authors.forename: P
authors.initials: P
authors.lastname: Törmälä
authors.forename: P
authors.initials: P
authors.lastname: Rokkanen
mesh_terms: D000818:Animals; D001846:Bone Development; D003692:Delayed-Action Preparations; D005269:Femur / Q000166:cytology / Q000000981:diagnostic imaging / Q000601:surgery*; D007773:Lactates / Q000627:therapeutic use*; D019344:Lactic Acid; D010027:Osteotomy / Q000379:methods*; D011091:Polyesters; D011108:Polymers / Q000627:therapeutic use*; D011817:Rabbits; D011859:Radiography; D013997:Time Factors; D014945:Wound Healing
chemical_list: D003692:Delayed-Action Preparations; D007773:Lactates; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)