title: Electrocardiographic alterations during treatment of mucocutaneous leishmaniasis with meglumine antimoniate and allopurinol.
abstract: The electrocardiographic (ECG) changes in Bolivian patients with mucocutaneous leishmaniasis, treated with meglumine antimoniate and allopurinol, were evaluated. Electric changes due to the antimonial compound appeared in 45% of the patients, and consisted of repolarization alteration, principally affecting the T wave and the S-T segment. The changes disappeared within 2 months following the end of the antimonial treatment. In patients with associated Chagas disease and leishmaniasis, antimonial therapy did not aggravate the ECG changes characteristic of Chagasic cardiopathy.
authors.affiliation: Instituto Boliviano de Biología de Altura, c/o Embajada de Francia, La Paz, Bolivia.
authors.forename: G
authors.initials: G
authors.lastname: Antezana
authors.forename: R
authors.initials: R
authors.lastname: Zeballos
authors.forename: C
authors.initials: C
authors.lastname: Mendoza
authors.forename: P
authors.initials: P
authors.lastname: Lyevre
authors.forename: L
authors.initials: L
authors.lastname: Valda
authors.forename: F
authors.initials: F
authors.lastname: Cardenas
authors.forename: I
authors.initials: I
authors.lastname: Noriega
authors.forename: H
authors.initials: H
authors.lastname: Ugarte
authors.forename: J P
authors.initials: JP
authors.lastname: Dedet
mesh_terms: D000293:Adolescent; D000328:Adult; D000493:Allopurinol / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002598:Chagas Cardiomyopathy / Q000503:physiopathology; D014355:Chagas Disease / Q000150:complications; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D007897:Leishmaniasis, Mucocutaneous / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008536:Meglumine / Q000627:therapeutic use*; D000077485:Meglumine Antimoniate; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D000493:Allopurinol; D008536:Meglumine; D000077485:Meglumine Antimoniate