title: Effects of intravesically administered verapamil HC1 (calcium entry blocker) on the bladder function in unanesthetized rats.
abstract: The effects of intravesically administered verapamil HCl (calcium entry blocker) on the bladder function were investigated using an experimental model for unanesthetized rats. Intravesical verapamil HCl caused a marked suppression of maximum intravesical pressure accompanied by an increase of residual urine in a dose-dependent manner. The effect almost disappeared 90 min after the elimination of verapamil HCl. It is tentatively suggested that the intravesical instillation of verapamil HCl could be a potent therapy for disorders of bladder function, such as uninhibited contraction.
authors.affiliation: Department of Urology, Kyoto Prefectural University of Medicine.
authors.forename: O
authors.initials: O
authors.lastname: Ukimura
authors.forename: M
authors.initials: M
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Hosoi
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000283:Administration, Intravesical; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects*; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D014700:Verapamil