title: The effect of endolymphatic sac obliteration on vestibular sensory hair bundles. A high-resolution scanning electron microscopic investigation.
abstract: A tannic acid-osmium staining technique and high-resolution scanning electron microscopy were used to demonstrate changes in the glycocalyx and ciliary interconnections of the vestibular sensory cells of guinea pigs after extradural obliteration of the endolymphatic sac and duct. Three months after the obliteration, it was possible to observe degeneration in the glycocalyx and the ciliary interconnections as well as the tip links. These findings suggest that the endolymphatic hydrops causes an endolymphatic ionic imbalance which affects the glycocalyx and ciliary interconnections resulting in further morphological changes of the cilia. The tip links, which are believed to be involved in sensory cell transduction, also seem to be affected.
authors.affiliation: Department of Otolaryngology, Hiroshima University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Takumida
authors.forename: K
authors.initials: K
authors.lastname: Hirakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
mesh_terms: D000818:Animals; D002923:Cilia / Q000648:ultrastructure; D004487:Edema / Q000473:pathology*; D004711:Endolymphatic Duct / Q000294:innervation / Q000648:ultrastructure; D004712:Endolymphatic Sac / Q000294:innervation / Q000648:ultrastructure*; D006023:Glycoproteins; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000648:ultrastructure*; D007759:Labyrinth Diseases / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D011134:Polysaccharides
chemical_list: D006023:Glycoproteins; D011134:Polysaccharides