Ciclosporin in Goodpasture's syndrome.
We report the case of a 39-year-old male patient with Goodpasture's syndrome. Despite therapy with prednisone, cyclophosphamide and plasma exchanges, serum creatinine (Scr) progressively increased up to 10.3 mg/dl (936 mumol/l) and hemoptysis recurred 3 months after initiation of treatment. Ciclosporin (CS) starting at 6 mg/kg/day was given. Scr began to decrease 2 weeks later and eventually stabilized at approximately 2.0 mg% (182 mumol/l). This case illustrates one of the potential uses of CS in human glomerular disease.
Quérin
S
S
Department of Medicine, Hôtel-Dieu de Montréal Hospital, Montréal, Québec, Canada.
Schürch
W
W
Beaulieu
R
R
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use*; D005920:Glomerular Mesangium / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D010951:Plasma Exchange; D011241:Prednisone / Q000627:therapeutic use
D016572:Cyclosporine; D003520:Cyclophosphamide; D011241:Prednisone