title: Lower limb paralysis: its effect on the recanalization of deep-vein thrombosis.
abstract: Fifty patients with lower limb deep-vein thrombosis (DVT) confirmed by venography were studied prospectively to determine the time required for recanalization. The patients were anticoagulated with heparin and warfarin for at least three months; impedance plethysmography, Doppler, and duplex scans were repeated at scheduled intervals. The 24 patients who were paralyzed took longer for recanalization than did the 26 nonparalyzed patients; this difference was statistically significant between the paraplegic-quadriplegic and nonparalyzed groups (54 vs 33 days; t = 2.12, p = .04). Patients with motor complete paraplegia or quadriplegia took longest for recanalization (57 days). Although most variables were not statistically significant on comparison, a somewhat longer recanalization time was seen in men and in those with DVTs located more proximally. Because of delay in recanalization, patients with lower limb paralysis may have persistent swelling due to venous insufficiency and may be at greater risk for development of the postphlebitic syndrome.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Northwestern University Medical School, Chicago, IL.
authors.forename: A C
authors.initials: AC
authors.lastname: Lim
authors.forename: E J
authors.initials: EJ
authors.lastname: Roth
authors.forename: D
authors.initials: D
authors.lastname: Green
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D010243:Paralysis / Q000150:complications*; D010992:Plethysmography, Impedance; D011446:Prospective Studies; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors; D014463:Ultrasonography; D014654:Vascular Patency
chemical_list: D000925:Anticoagulants