Use of lithium for treatment of estrogen-induced bone marrow hypoplasia in a dog.
Marrow hypoplasia and consequent pancytopenia caused by simultaneous administration of estradiol cyclopentylpropionate and diethylstilbestrol were diagnosed in a 6-year-old Old English Sheep-dog. The dog was treated with lithium carbonate (11 mg/kg of body weight, PO, q 12 h) for 6 weeks. Despite the generally grave prognosis associated with estrogen toxicosis, lithium treatment was apparently successful in inducing regeneration of the bone marrow. Side effects of lithium treatment were not noticed.
Hall
E J
EJ
Veterinary Hospital, University of Pennsylvania, Philadelphia 19104.
D000658:Amoxicillin / Q000627:therapeutic use; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000150:complications / Q000662:veterinary*; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D008094:Lithium / Q000627:therapeutic use*; D010198:Pancytopenia / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary
D004958:Estradiol; D004054:Diethylstilbestrol; C007630:estradiol 17 beta-cypionate; D000658:Amoxicillin; D008094:Lithium