Improvement of motor performance of HIV-positive patients under AZT therapy.
We performed motor tests (most rapid alternating movements [MRAMs] of index fingers and most rapid contractions [MRCs] of voluntary isometric index finger extensions) in HIV-positive patients with (group 1) and without (group 2) AZT treatment over a 6-month period. Whereas MRAMs remained uninfluenced, MRCs showed a clear improvement in the treated group and a decline in the nontreated group, according to the T helper cell counts. MRCs were not only a sensitive test procedure for detecting subclinical lesions in HIV-positive patients, but also a reliable therapy control measurement.
Arendt
G
G
Department of Neurology, University of Duesseldorf, Germany.
Hefter
H
H
Buescher
L
L
Hilperath
F
F
Elsing
C
C
Freund
H J
HJ
D006679:HIV Seropositivity / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007958:Leukocyte Count; D009068:Movement / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000187:drug effects; D013601:T-Lymphocytes / Q000473:pathology; D015215:Zidovudine / Q000627:therapeutic use*
D015215:Zidovudine