title: Composition and turnover of phospholipids and neutral lipids in human breast cancer and reference tissues.
abstract: The phospholipid (PL) content was 4-fold higher while the triacylglycerol (TG) content tended to be 65% lower in human breast cancer tissues as compared with non-cancerous reference parts from excised breast tissues. The variation in TG content among breast tissues was very large while that of PL was relatively small. The fatty acid compositions of PL were significantly different between the cancer and reference tissues; the proportions of octadecenoate (18:1), docosahexaenoate (22:6n-3), the total n-3 fatty acids and the n-3/n-6 ratio, but not the proportion of arachidonate (20:4n-6), were significantly higher in the major PL of cancer tissues as compared with those of the reference tissues. No significant differences were observed in the proportion of the major fatty acids of TG in these tissues. The turnover of lipids was faster in the cancer tissues than in the reference tissues. The turnover of TG was faster than that of PL in the cancer tissues, whereas the opposite was true in the reference tissues, indicating significant differences in lipid metabolism between these tissues. A striking difference in the n-3 and n-6 fatty acids of the reference tissues noted for Japanese and Finnish women is discussed in relation to the roles of eicosanoids and eicosanoid precursors in mammary carcinogenesis.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Okuyama
authors.forename: J
authors.initials: J
authors.lastname: Yura
authors.forename: H
authors.initials: H
authors.lastname: Takeyama
authors.forename: N
authors.initials: N
authors.lastname: Shinagawa
authors.forename: N
authors.initials: N
authors.lastname: Tsuruga
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Kawase
authors.forename: T
authors.initials: T
authors.lastname: Tsujimura
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000737:chemistry*; D001943:Breast Neoplasms / Q000737:chemistry / Q000378:metabolism*; D015777:Eicosanoids / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D014280:Triglycerides / Q000032:analysis
chemical_list: D015777:Eicosanoids; D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; D005990:Glycerol