A new tetracycline antibiotic with antitumor activity. II. The structural elucidation of SF2575.
The structure of a new antitumor antibiotic SF2575, has been determined by spectroscopic analyses of the antibiotic and its alkaline degradation products. The relative stereochemistry has been confirmed by X-ray crystallographic analysis. The antibiotic has a 2-naphthacenecarboxamide carbon skelton which is structurally related to the tetracycline antibiotics and it is unique by bearing C-glycoside, salicyclic acid and angelic acid moieties.
Hatsu
M
M
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Sasaki
T
T
Gomi
S
S
Kodama
Y
Y
Sezaki
M
M
Inouye
S
S
Kondo
S
S
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D008968:Molecular Conformation; D013754:Tetracyclines / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D013754:Tetracyclines; C074360:SF 2575