Interactions among antioxidants in health and disease: vitamin E and its redox cycle.
Probably most diseases at some point during their course involve free radical reactions in tissue injury. In some cases, free radical reactions may be involved in multiple sites and at different stages of a chronic disease. So, both acute and degenerative diseases are thought to involve free radical reactions in tissue injury. An overview will be given of the evidence for the occurrence of free radicals and the importance of antioxidant interventions, with particular reference to the lipophilic antioxidant vitamin E (tocopherols and tocotrienols).
Packer
L
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Department of Molecular and Cell Biology, University of California, Berkeley 94720.
D000375:Aging; D000787:Angina Pectoris / Q000188:drug therapy; D000970:Antineoplastic Agents; D000975:Antioxidants; D016718:Arachidonic Acid / Q000502:physiology; D002908:Chronic Disease; D003327:Coronary Disease / Q000188:drug therapy; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D010084:Oxidation-Reduction; D005082:Physical Exertion; D015290:Second Messenger Systems; D015398:Signal Transduction; D014018:Tissue Distribution; D014810:Vitamin E / Q000737:chemistry / Q000502:physiology* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D000975:Antioxidants; D014810:Vitamin E; D016718:Arachidonic Acid