Chronic granulomatous disease presenting with osteomyelitis: favorable response to treatment with interferon-gamma.
A 3-year-old boy with chronic granulomatous disease presented with abscesses related to underlying osteomyelitis. Treatment with appropriate antibiotics resulted in resistance of the organisms. Treatment with interferon-gamma was encouraging in that it caused the osteomyelitis to heal and prevented its relapse when used as long-term prophylaxis.
Gill
P J
PJ
Department of Orthopaedic Surgery, University of Cape Town, Red Cross Children's Hospital, South Africa.
Goddard
E
E
Beatty
D W
DW
Hoffman
E B
EB
D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use; D008297:Male; D010019:Osteomyelitis / Q000150:complications* / Q000628:therapy; D011994:Recombinant Proteins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use
D011994:Recombinant Proteins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D007371:Interferon-gamma