title: Plasma catecholamine concentrations after successful resuscitation in patients.
abstract: OBJECTIVE
  To measure plasma catecholamine concentrations after cardiopulmonary resuscitation (CPR) and to correlate catecholamine concentrations with heart rate (HR), BP, and plasma glucose and lactate concentrations.
  
  
  METHODS
  Prospective, descriptive study.
  
  
  METHODS
  Emergency medical service at a University Hospital.
  
  
  METHODS
  Ten patients (58 to 85 yrs) with out-of-hospital cardiac arrest.
  
  
  METHODS
  At 1, 5, 15, 30, and 60 mins after restoration of spontaneous circulation, blood samples were drawn and BP and HR were measured. Plasma catecholamine concentrations were measured by high-pressure liquid chromatography and plasma glucose and lactate concentrations were measured by enzymatic methods.
  
  
  RESULTS
  Median plasma epinephrine and norepinephrine concentrations were 136.3 micrograms/L (136,300 pg/mL), range 27.6 to 397.6 micrograms/L (27,600 to 397,600 pg/mL), and 4.7 micrograms/L (4700 pg/mL), range 1.8 to 14.5 micrograms/L (1800 to 14,500 pg/mL), respectively, at 1 min. Median plasma epinephrine and norepinephrine concentrations decreased to 8.7 micrograms/L (8700 pg/mL), range 1.2 to 55.0 micrograms/L (1200 to 55,000 pg/mL) and 1.9 micrograms/L (1900 pg/mL), range 1.3 to 5.8 micrograms/L (1300 to 5800 pg/mL), respectively, at 60 mins after restoration of spontaneous circulation. Epinephrine concentrations decayed with a semilogarithmic decay pattern. The half-life for the alpha phase was 2.2 mins and was 38.7 mins for the beta phase. Mean values of systolic arterial pressure were between 136 +/- 23 mm Hg at 1 min and 120 +/- 15 mm Hg at 30 mins. Median plasma glucose concentrations were between 8.2 mmol/L (147.7 mg/dL; range 5.8 to 11.2 mmol/L [104.5 to 201.8 mg/dL]) at 1 min and 13.9 mmol/L (250.4 mg/dL; range 9.7 to 16.6 mmol/L [174.8 to 299.1 mg/dL]) at 30 mins. Lactate values were between 11.4 mmol/L (range 4.7 to 16.5) at 1 min and 5.2 mmol/L (range 2.7 to 12.5) at 60 mins. No significant correlations were found between circulating catecholamine concentrations and the other variables.
  
  
  CONCLUSIONS
  After CPR, plasma catecholamine concentrations remained at high values but they did not lead to increases in BP, HR, or circulating glucose concentrations.
authors.affiliation: Clinic of Anesthesiology, Ulm University, FRG.
authors.forename: A W
authors.initials: AW
authors.lastname: Prengel
authors.forename: K H
authors.initials: KH
authors.lastname: Lindner
authors.forename: H
authors.initials: H
authors.lastname: Ensinger
authors.forename: A
authors.initials: A
authors.lastname: Grünert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D016887:Cardiopulmonary Resuscitation / Q000592:standards*; D004298:Dopamine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D004636:Emergency Service, Hospital; D004837:Epinephrine / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D006323:Heart Arrest / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D006439:Hemodynamics; D006785:Hospitals, University; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood* / Q000493:pharmacokinetics; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007773:Lactates; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine