title: Cytotoxic activity of bis-[di-n-butyl(4-aminosalicylato)tin] oxide, NSC: 628561, bis-[diphenyl(4-aminosalicylato)tin] oxide, NSC: 628562, and some related compounds, against a series of human tumour cell lines.
abstract: Bis[di-n-butyl (4-aminosalicylato)tin] oxide [NSC: 628561] (compound 1), bis [diphenyl(4-aminosalicylato)tin] oxide [NSC: 628562] (compound 2), and six other analogous compounds of the type [n-Bu2 (XYZ-C6H2COO)Sn]2O (compounds 3 to 8), were tested in vitro at the National Cancer Institute, Bethesda, Maryland, USA, for cytotoxic activity against a series of human cell lines. Compounds 1, 6 and 8 score globally satisfactorily since four of the five relevant sensitivity or selectivity parameters, DGI50, DTGI or DLC50, DH and MGDH, are statistically significant. Compounds 3 and 7 are less satisfactory because only three such parameters are statistically significant. For compound 2, only two of the parameters are significant.
authors.affiliation: Vrije Universiteit Brussel, AOSC Department, Faculty of Applied Sciences, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Gielen
authors.forename: R
authors.initials: R
authors.lastname: Willem
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009947:Organotin Compounds / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009947:Organotin Compounds; C074102:bis(di-n-butyl(4-aminosalicylate)tin)oxide; C074103:bis(diphenyl(4-aminosalicylate)tin)oxide