Inhibiting effects of serotonin antagonists on the proliferation of mercuric chloride stimulated human peripheral blood T lymphocytes.
The serotonin antagonists ketanserin and methiotepine were tested for a modulating effect on the proliferative response of human peripheral blood T lymphocytes to mercuric chloride. This response was inhibited by ketanserin at 8 x 10(-5) mol/l and by methiotepine at 8.0 x 10(-6) mol/l. There were no additive effects at these concentrations of antagonists and at 10(-5) mol/l of serotonin. Low concentrations of ketanserin eliminated the inhibiting effect of serotonin on mercuric chloride induced proliferation of T lymphocytes. It thus seems as if the inhibiting effect of serotonin on T lymphocytes is mediated by 5-HT1c or 5-HT2 receptors, while the mechanism for the intrinsic inhibiting effect of the antagonists at present is unknown.
Nordlind
K
K
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Sundström
E
E
Bondesson
L
L
D000704:Analysis of Variance; D002478:Cells, Cultured; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008627:Mercuric Chloride / Q000494:pharmacology; D008719:Methiothepin / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects*
D012702:Serotonin Antagonists; D012701:Serotonin; D008627:Mercuric Chloride; D008719:Methiothepin; D007650:Ketanserin