[Cutaneous lupus erythematosus and cardiolipin antibodies. Incidence and clinical significance].
In recent years, the importance of antiphospholipid antibodies in systemic lupus erythematosus and various other dermatological and internal diseases has been recognized. Characteristic symptoms associated with these antibodies are venous and arterial thrombosis, recurrent fetal loss, thrombocytopenia, and haemolytic anaemia. Two antiphospholipid antibody subgroups that are clinically relevant can be discerned: anticardiolipin antibodies and lupus coagulant. In this study, 51 clinically well-characterized patients with predominantly cutaneous lupus erythematosus were screened for the presence of anticardiolipin antibodies. Anticardiolipin antibodies could be detected in only three patients. These data suggest that, in patients with cutaneous lupus erythematosus, anticardiolipin antibodies should be measured only in the presence of symptoms associated with antiphospholipid antibodies.
Kind
P
P
Hautklinik, Heinrich Heine-Universität Düsseldorf.
Schuppe
H C
HC
Jung
K P
KP
Degitz
K
K
Lakomek
H J
HJ
Goerz
G
G
D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis / Q000276:immunology*; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis / Q000276:immunology
D001323:Autoantibodies; D002308:Cardiolipins
Kutaner Lupus erythematodes und Kardiolipin-Antikörper. Vorkommen und klinische Bedeutung.