title: Course of carotid artery occlusions with impaired cerebrovascular reactivity.
abstract: OBJECTIVE
  Retrospective studies have found a close correlation between an impaired cerebrovascular reserve capacity and the incidence of hemodynamic stroke. The present study evaluates this relation prospectively.
  
  
  METHODS
  We measured the CO2 reactivity in 85 patients with internal carotid artery occlusions by transcranial Doppler sonography (Doppler CO2 test). All patients were prospectively followed for 38 +/- 15 (mean +/- SD) months.
  
  
  RESULTS
  In the group with sufficient CO2 reactivity, four of 48 (8%) developed ipsilateral transient symptoms, none a stroke. In cases with diminished or exhausted cerebrovascular reserve capacity, 12 of 37 (32%) suffered an ipsilateral event (four transient ischemic attacks, eight strokes) (p less than 0.01).
  
  
  CONCLUSIONS
  The Doppler CO2 test seems to be a valuable method of estimating the risk of stroke in patients with carotid artery occlusions.
authors.affiliation: Department of Neurology, University of Ulm, FRG.
authors.forename: B
authors.initials: B
authors.lastname: Kleiser
authors.forename: B
authors.initials: B
authors.lastname: Widder
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001808:Blood Vessels / Q000503:physiopathology; D002545:Brain Ischemia / Q000209:etiology; D002245:Carbon Dioxide; D002340:Carotid Artery Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002546:Ischemic Attack, Transient / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D002245:Carbon Dioxide