The role of interleukin-6 in vitamin A deficiency during Plasmodium falciparum malaria and possible consequences for vitamin A supplementation.
Kinetics of serum levels of interleukin-6 (IL-6) were studied in patients with acute Plasmodium falciparum malaria in relation to vitamin A and its binding proteins, retinol binding protein (RBP) and pre-albumin. It was found that IL-6 levels followed the rise and decrease of parasitaemia by 12 hr and correlated inversely with levels of vitamin A and its binding proteins. These data suggest that vitamin A supplementation alone might still be insufficient to restore a malaria-induced vitamin A deficiency.
Tabone
M D
MD
INSERM U 313, Hôpital de la Salpétrière, Paris, France.
Muanza
K
K
Lyagoubi
M
M
Jardel
C
C
Pied
S
S
Amedee-Manesme
O
O
Grau
G E
GE
Mazier
D
D
D000328:Adult; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D016778:Malaria, Falciparum / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014801:Vitamin A / Q000097:blood / Q000627:therapeutic use*; D014802:Vitamin A Deficiency / Q000188:drug therapy / Q000209:etiology*
D015850:Interleukin-6; D014801:Vitamin A