title: [Clinical profile and treatment of acute pulmonary embolism].
abstract: The clinical profiles of 15 patients with acute pulmonary embolism (APE) were analysed. The most common symptoms of APE were tachypnea and tachycardia with sudden onset. Both PO2 and PCO2 had decreased in almost all patients (mean PO2: 50 mmHg, PCO2: 30 mmHg). Chest roentgenogram (X-P) revealed hyperlucency of the lung field, prominence of proximal pulmonary artery and cardiac enlargement. ECG showed SI QIII TIII and ST-T changes in half of the cases. These changes, however, disappeared within 4 days in most patients. Lung scan and digital subtraction pulmonary angiography were useful for the diagnosis. Sixty percent of patients recovered only by medical therapy, and embolectomy was performed in only two patients. Fifty-three percent of patients were, however, considered to be candidates for the embolectomy, and half of them died because of ineffective medical therapy. From these results we concluded that the combination of severe hypoxemia and hypocapnia with abnormal chest X-P can be used for a diagnostic or therapeutic decision. If a patient has those findings, pulmonary angiography is recommended together with thrombolytic therapy. If a large embolus is detected, embolectomy is mandatory. The need for surgical therapy for APE is greater than we had imagined.
authors.affiliation: First Department of Surgery, Kagawa Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Maeta
authors.forename: S
authors.initials: S
authors.lastname: Imawaki
authors.forename: Y
authors.initials: Y
authors.lastname: Shiraishi
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Shirakawa
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015901:Angiography, Digital Subtraction; D001784:Blood Gas Analysis; D004562:Electrocardiography; D005260:Female; D016670:Gabexate / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000000981:diagnostic imaging; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D013902:Radiography, Thoracic; D011877:Radionuclide Imaging; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D016670:Gabexate; D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator