[Zonisamide induced tremor--report of two cases].
Zonisamide is a new antiepileptic drug which has a wide range of antiepileptic efficacy. This drug is becoming widely to be used for patients with refractory epilepsies. The author reports two patients who developed resting and postural hand tremor after administration of zonisamide. The tremor was confined to the upper extremities and was enhanced with the emotional stress. The tremor has 4-5 Hz frequency and was severe enough to disturb their daily activities. Mild cogwheel rigidity was seen, but neither akinesia nor gait disturbance was recognized. The symptoms disappeared completely after cessation of the drug. This side effect should always be kept in mind in the treatment with zonisamide.
Taira
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Department of Neurosurgery, Itabashi Chuo Medical Hospital, Japan.
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004576:Electromyography; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects*; D011187:Posture; D012146:Rest; D014202:Tremor / Q000139:chemically induced* / Q000503:physiopathology; D000078305:Zonisamide
D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide