title: Bioconversion of tamoxifen by microbes.
abstract: Screening studies of tamoxifen (TAM) have shown that only one culture, Streptomyces rimosus ATCC 2234 was able to metabolize tamoxifen to 4-hydroxy tamoxifen (OHT) which was obtained in a 10% yield and chemically identified by 2 D nmr spectroscopy. A number of microorganisms were capable of biotransforming TAM to tamoxifen-N-oxide (TNO), and desmethyltamoxifen (DMT). The chemical identity of the isolated metabolites was achieved using gas chromatography/mass spectrometry and different nmr spectroscopic techniques.
authors.affiliation: Department of Pharmacognosy, University of Mississippi, Oxford 38677.
authors.forename: S H
authors.initials: SH
authors.lastname: el-Sharkawy
mesh_terms: D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D005658:Fungi / Q000378:metabolism*; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000493:pharmacokinetics*
chemical_list: D013629:Tamoxifen; C016601:afimoxifene; C028787:N-desmethyltamoxifen