Analysis of sodium-23 nuclear magnetic resonance spin-lattice relaxation for the study of the intracellular sodium state.
Sodium-23 Nuclear Magnetic Resonance relaxation spectroscopy has been used to investigate the state of intracellular Na+ in control and CCl4-treated rat livers. The analysis of spin-lattice relaxation rates at 1.88 and 7.07 Tesla based on a two-site exchange model led to estimates of pertinent modulation times. Also it has been found that a relatively high quantity of Na+ (PB = 1.59 x 10(-2)) is bound to charged sites of intracellular macromolecules or membranes. The degree of binding strongly decreases in CCl4 treated rat livers.
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Dipartimento di Scienze Chimiche, Università degli Studi di Cagliari, Italy.
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D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008433:Mathematics; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism*
D012964:Sodium; D002251:Carbon Tetrachloride