The effect of myo-inositol treatment on basement membrane thickening in the BB/W-rat retina.
A polyol-pathway related perturbation of myo-inositol metabolism has been invoked in the pathogenesis of diabetic complications, including retinal microvasculopathy. Previous studies have demonstrated a beneficiary effect of aldose reductase inhibition on basement membrane thickening of retinal microvessels in diabetic animals. In the present study we demonstrate a significant but partial effect on basement membrane thickening following myo-inositol supplementation. Qualitative structural changes, such as nodular swellings, fibrillar changes and basement membrane projections were not effected by myo-inositol supplementation, suggesting that although abnormal myo-inositol tissue levels may play a role in basement membrane thickening, other factors may be of primary pathogenetic importance.
Chakrabarti
S
S
Department of Pathology, University of Manitoba, Winnipeg, MB, Canada.
Sima
A A
AA
D000818:Animals; D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology*; D001786:Blood Glucose / Q000378:metabolism; D002196:Capillaries / Q000187:drug effects / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000473:pathology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000473:pathology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D007294:Inositol / Q000633:toxicity*; D011236:Prediabetic State / Q000097:blood / Q000473:pathology*; D051381:Rats; D011913:Rats, Inbred BB; D012016:Reference Values; D012160:Retina / Q000187:drug effects / Q000473:pathology*; D012171:Retinal Vessels / Q000187:drug effects / Q000473:pathology*
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007294:Inositol