Destructive arthritis without lymphocyte infiltration in H2-c-fos transgenic mice.
H2-c-fos transgenic (c-fos+) mice are characterized by the inability to raise specific IgG antibodies against immunizing Ag. To examine the contribution of Ag-specific IgG antibody to the development of arthritis, Ag-induced arthritis was produced in c-fos+ mice and their control littermates (c-fos- mice). Intra-articular injection of OVA into c-fos- mice hyperimmunized with OVA induced destructive arthritis with massive lymphocyte infiltration. The c-fos+ mice also developed destructive arthritis comparable in degree with that seen in c-fos- mice. However, joints from the c-fos+ mice had few or no infiltrating lymphocytes. The majority of cells invading the extensively eroded collagenous tissue in the c-fos+ mice had a mesenchymal appearance. These cells, producing excess amounts of c-Fos protein, adhered to and invaded the cartilage matrix when cultured on cartilage slices. These cells, thus, appear to directly cause joint destruction in c-fos+ mice.
Shiozawa
S
S
Department of Medicine, Kobe University School of Medicine, Japan.
Tanaka
Y
Y
Fujita
T
T
Tokuhisa
T
T
D000818:Animals; D001168:Arthritis / Q000209:etiology / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology; D002356:Cartilage / Q000473:pathology; D016762:Genes, fos; D007074:Immunoglobulin G / Q000502:physiology*; D008214:Lymphocytes / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000276:immunology; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis; D013582:Synovial Fluid / Q000166:cytology
D007074:Immunoglobulin G; D016760:Proto-Oncogene Proteins c-fos; D010047:Ovalbumin