title: Quantitative relationships of the interaction between sound and kanamycin.
abstract: It is well known that the ototoxicity resulting from the use of aminoglycoside antibiotics in experimental animals can be augmented by intense sound. However, the dose-effect relationship of this interaction is not known. This study was designed to determine the shape of this dose-effect relationship in guinea pigs at sound intensities approaching those that would be experienced by patients receiving aminoglycoside antibiotics. We found a linear relationship between the probit of the percent of missing cochlear outer hair cells and decibel-A scale sound intensity when the animals were treated with kanamycin plus white noise ranging from 115 to 45 dBA.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Oregon Hearing Research Center, Portland 97201.
authors.forename: R E
authors.initials: RE
authors.lastname: Brummett
authors.forename: K E
authors.initials: KE
authors.lastname: Fox
authors.forename: J B
authors.initials: JB
authors.lastname: Kempton
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000473:pathology; D007612:Kanamycin / Q000494:pharmacology*; D012044:Regression Analysis; D013016:Sound
chemical_list: D007612:Kanamycin