An evaluation of the penetration of cefuroxime axetil into human paranasal sinus tissue.
Nineteen patients presenting for sinus surgery were studied to evaluate the percentage penetration from serum to paranasal sinus tissue of a single orally administered dose of cefuroxime axetil. The methods and results are presented. Cefuroxime penetrates well into human sinus mucosa following oral administration and the concentrations obtained exceed minimum inhibitory concentrations of cefuroxime for the most common pathogens in sinusitis.
Sudderick
R M
RM
Dept. of O.R.L., Charing Cross Hospital, London, United Kingdom.
Lund
V J
VJ
Thomson
J P
JP
McCombe
A
A
Mackay
I S
IS
D000284:Administration, Oral; D001424:Bacterial Infections / Q000188:drug therapy; D002444:Cefuroxime / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D010256:Paranasal Sinuses / Q000378:metabolism*; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011446:Prospective Studies; D012852:Sinusitis / Q000188:drug therapy
D011355:Prodrugs; D002444:Cefuroxime; C040738:cefuroxime axetil