The influence of calcium on the ototoxicity of aminoglycosides.
Aminoglycosides in aquarium water produce a temporary impairment of sensitivity in the lateral line organ of fish. If Ca++ ions are supplied at the same time, the impairment in lateral line sensitivity can be alleviated in a dose-dependent manner. This mechanism appears to be based on competitive antagonism.
Kaus
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Klinik für Hals-, Nasen- und Ohrenkrankheiten, Dominikus Krankenhaus, Düsseldorf, Germany.
D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects* / Q000502:physiology; D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005399:Fishes / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008954:Models, Biological; D009355:Neomycin / Q000037:antagonists & inhibitors / Q000633:toxicity*
D009355:Neomycin; D002122:Calcium Chloride