Influence of hormonal treatment on the response of the rat isolated uterus to histamine and histamine receptor agonists.
The response of the isolated uterus to histamine and histamine agonists was investigated in progesterone- and oestrogen-treated rats. The uterine inhibitory responses to histamine and 4-methylhistamine (a histamine H2 receptor agonist) were similar in KCl-contracted uteri from progesterone- and oestrogen-treated rats. The histamine H1 receptor agonist, 2-pyridyl-ethylamine, produced a relaxant response only in progesterone dominant uterus. This was inhibited by the histamine H1 receptor antagonist. In the rat isolated uterus which was not preconstricted by KCl, neither histamine, 4-methylhistamine, nor 2-pyridyl-ethylamine produced any effect in the presence or absence of ranitidine. Ranitidine competitively antagonized the histamine-relaxant uterine response in oestrogen-treated rats (pA2 = 7.21 (6.83-7.58)), but not in progesterone-treated rats, except in the presence of clemizole (10(-7) M) when the pA2 value of ranitidine against histamine was similar to that obtained in oestrogen-treated rats (pA2 = 6.74 (6.64-6.85)). These results indicate that treatment with ovarian steroids influences responses mediated by the histamine receptors of the isolated rat uterus. Both histamine H2 and H1 receptors contribute to the uterine inhibitory effect of histamine in progesterone-treated rats.
Rubio
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Departament de Farmacologia, Facultat de Medicina i Odontologia, Universitat de València, Spain.
Estañ
L A
LA
Morales-Olivas
F J
FJ
Martinez-Mir
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I
D000818:Animals; D004347:Drug Interactions; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006632:Histamine / Q000494:pharmacology*; D008761:Methylhistamines / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011968:Receptors, Histamine / Q000187:drug effects*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
D004967:Estrogens; D008761:Methylhistamines; D011725:Pyridines; D011968:Receptors, Histamine; D011374:Progesterone; C025566:4-methylhistamine; D011189:Potassium Chloride; D006632:Histamine; D011899:Ranitidine; C006183:2-(2-aminoethyl)pyridine