Follicular center cell lymphoma of childhood in Japan.
Following a histologic review of 108 patients with childhood lymphoma from 20 hospitals in the Osaka, Hyogo, Nara, and Kyoto prefectures of Japan during the period 1964-1989, 16 cases (15%) were classified as follicular center cell (FCC) lymphomas. None had a follicular pattern of proliferation. The age range was from 2 to 15 years (median 10) with no peak incidence. The male/female ratio was 1.3:1. Presentation was nodal in 10 patients and extranodal in 6. Chronic infection and other predisposing factors for the development of FCC lymphomas in childhood are discussed, with a review of the literature.
Aozasa
K
K
Department of Pathology, Nara Medical University, Kashihara, Japan.
Ohsawa
M
M
Hashimoto
K
K
Kobayashi
Y
Y
Kobashi
Y
Y
Shima
N
N
Yamabe
H
H
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008224:Lymphoma, Follicular / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D008297:Male; D012737:Sex Factors