Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year.
Studies of cerebral oxidative metabolism were carried out by phosphorous magnetic resonance spectroscopy during the first week of life in 52 infants with clinical and/or biochemical evidence of birth asphyxia. 15 infants died and the 37 survivors were assessed by a wide range of neurodevelopmental tests at one year of age. The minimum recorded values for cerebral phosphocreatine/inorganic phosphate concentration ratio (an index of oxidative metabolism) were related to outcome. The results showed a significant relation between the extent of derangement of oxidative metabolism and the severity of adverse outcomes, including death, neurodevelopmental impairment and reduced head growth.
Roth
S C
SC
Department of Paediatrics, University College and Middlesex School of Medicine, London.
Edwards
A D
AD
Cady
E B
EB
Delpy
D T
DT
Wyatt
J S
JS
Azzopardi
D
D
Baudin
J
J
Townsend
J
J
Stewart
A L
AL
Reynolds
E O
EO
D000255:Adenosine Triphosphate / Q000378:metabolism; D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000503:physiopathology*; D001724:Birth Weight / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism
D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate