[The effect of hypoxia due to iron-deficiency anemia on the physicochemical properties of biological membranes].
The lipid structure and Ca2+ permeability of red blood cell, hepatocyte and cardiomyocyte membranes were determined while investigating the effect of hypoxia caused by iron deficiency anemia upon the structural and functional state of biological membranes. The lipid composition and barrier characteristics of membranes change under conditions of hypoxia caused by experimental iron deficiency anemia. Quantitative changes in the cell membrane lipids may be considered as an important molecular mechanism of Ca2+ transport disorder in membranes, increase of Ca2+ permeability producing its surplus in the cells and subsequent metabolic homeostatic disturbances.
Mkhitarian
L S
LS
Korotkoruchko
A H
AH
Lipkan
H M
HM
D000747:Anemia, Hypochromic / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D000818:Animals; D002118:Calcium / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002463:Cell Membrane Permeability / Q000502:physiology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004910:Erythrocyte Membrane / Q000502:physiology*; D006321:Heart / Q000503:physiopathology*; D000860:Hypoxia / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D007501:Iron / Q000097:blood; D008099:Liver / Q000503:physiopathology*; D008563:Membrane Lipids / Q000032:analysis; D051381:Rats
D008563:Membrane Lipids; D007501:Iron; D002118:Calcium
Vplyv gipoksiï, zumovlenoï zalizodefitsytnoiu anemiieiu, na fiziko-khimichni vlastyvosti biolohichnykh membran.