title: [An experimental study on CPR and lung metabolism].
abstract: We investigated the influence of cardiac arrest upon the metabolic function of the lungs, especially on prostaglandins and angiotensin in pulmonary arterial and venous blood (PA, PV) in dogs resuscitated after cardiac arrest. Experiments were performed on 36 dogs. Cardiac arrest was produced with the electric ventricular fibrillation. The resuscitation was carried out with 100% oxygen using a ventilator. Open chest cardiac massage was performed and defibrillation was done with DC of 25-75 W.sec. Epinephrine and 7% sodium carbonate were administered. Experimental groups were as follow; Group 1 (G I): CPR 5 minutes after the cardiac arrest. Group 2 (G II): CPR 10 minutes after the cardiac arrest. There were no significant differences between G I and G II in hemodynamics and blood gas. AT I was higher in PA than in PV, and AT II showed no significant difference between PA and PV. PGE2 and PGF2 alpha showed no significant changes in G I. And in G II they reached the peak in PA after resuscitation, PGE2 increased in PV, and PGF2 alpha showed no significant changes in PV. TXB2 and 6-keto-PGF1 alpha showed no differences between PA and PV, and they reached a peak after resuscitation in G II.
authors.affiliation: Department of Anesthesiology, Tokyo Medical College.
authors.forename: H
authors.initials: H
authors.lastname: Kusagaya
mesh_terms: D000809:Angiotensins / Q000097:blood*; D000818:Animals; D016887:Cardiopulmonary Resuscitation; D004285:Dogs; D008168:Lung / Q000378:metabolism*; D011453:Prostaglandins / Q000097:blood*; D011651:Pulmonary Artery; D011667:Pulmonary Veins
chemical_list: D000809:Angiotensins; D011453:Prostaglandins