title: Synthesis of 7-O-[2,6-dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)- alpha-L-talopyranosyl]daunomycinone.
abstract: 7-O-[2,6-Dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)-alpha -L- talopyranosyl]daunomycinones (7a-7c) have been prepared by condensation of 3'-O-benzoyl derivative of 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)daunomycinone with 2,3-difluorotetrahydropyran as the key reaction. Antitumor activities of these compounds are described.
authors.affiliation: Institute of Bioorganic Chemistry, Kawasaki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takagi
authors.forename: H
authors.initials: H
authors.lastname: Sohtome
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: S
authors.initials: S
authors.lastname: Umezawa
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006027:Glycosides / Q000138:chemical synthesis
chemical_list: D000903:Antibiotics, Antineoplastic; D006027:Glycosides; C074364:7-O-(2,6-dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)talopyranosyl)daunomycinone; D003630:Daunorubicin