title: T-cell acute lymphoblastic leukemia following therapy of rhabdomyosarcoma.
abstract: Multiple studies have documented an increased risk of secondary malignancies in patients receiving alkylating agents. Secondary leukemia following chemotherapy accounts for about 20% of all secondary neoplasms; most are acute nonlymphocytic. Secondary acute lymphoblastic leukemia has rarely been reported in either adult or childhood cancer. We report the development of acute T-cell lymphoblastic leukemia in a child following successful treatment of a paravertebral embryonal rhabdomyosarcoma (ERS). Southern blot analysis of DNA extracted from the T-cell lymphoblasts, using probes homologous to loci on the short arm of chromosome 11; P-calcitonin, P40.1 and H-ras, did not demonstrate the chromosomal loss of heterozygosity (LOH), a common feature of embryonal rhabdomyosarcoma. The data presented support the assumption that de novo leukemia emerged following treatment of the primary malignancy.
authors.affiliation: Department of Pediatric-Hematology/Oncology, Beilinson Medical Center, Petah Tikva, Israel.
authors.forename: C
authors.initials: C
authors.lastname: Kaplinsky
authors.forename: A
authors.initials: A
authors.lastname: Frisch
authors.forename: I J
authors.initials: IJ
authors.lastname: Cohen
authors.forename: Y
authors.initials: Y
authors.lastname: Goshen
authors.forename: L
authors.initials: L
authors.lastname: Jaber
authors.forename: I
authors.initials: I
authors.lastname: Yaniv
authors.forename: B
authors.initials: B
authors.lastname: Stark
authors.forename: H
authors.initials: H
authors.lastname: Tamary
authors.forename: R
authors.initials: R
authors.lastname: Zaizov
mesh_terms: D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000139:chemically induced* / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000235:genetics; D012208:Rhabdomyosarcoma / Q000188:drug therapy* / Q000532:radiotherapy
chemical_list: D004273:DNA, Neoplasm