Elevation of immunoreactive serum Mn-superoxide dismutase in patients with acute myocardial infarction.
Serum Mn-superoxide dismutase (Mn-SOD) levels were determined in patients with acute myocardial infarction by an enzyme-linked immunosorbent assay (ELISA). The serial determinations performed on 29 patients with acute myocardial infarction indicated that Mn-SOD appears in serum in a biphasic manner; an early small elevation was observed at approximately 16.2 (+/- 7.3) h and a high elevation at approximately 108 (+/- 20.6) h after the onset of symptoms. A negative correlation was found between the maximum value of the late elevation of Mn-SOD and left ventricular function. Plasma levels of tumor necrosis factor-alpha (TNF-alpha) were also elevated in acute myocardial infarction. These facts suggest that TNF-alpha secretion from the infarcted area resulted in the production of Mn-SOD and that the induced Mn-SOD was released from myocytes into serum through damaged membranes, resulting in the late elevation.
Suzuki
K
K
Department of Biochemistry, Osaka University Medical School, Japan.
Kinoshita
N
N
Matsuda
Y
Y
Higashiyama
S
S
Kuzuya
T
T
Minamino
T
T
Tada
M
M
Taniguchi
N
N
D000328:Adult; D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D016277:Ventricular Function, Left
D014409:Tumor Necrosis Factor-alpha; D013482:Superoxide Dismutase