[Inhibitory effect of peptide YY on gastric acid output in rats].
The purpose of this study was to elucidate the effect of Peptide YY (PYY) on gastric acid output in association with gastric mucosal blood flow (GMBF), acetylcholine (ACh) release in the gastric wall and gastric vascular perfusion pressure in rats. Baclofen stimulated the gastric acid output and GMBF in a dose-dependent manner. Both atropine sulfate and truncal vagotomy completely abolished the effect of baclofen. PYY caused inhibition of baclofen-stimulated gastric acid output and reduction in baclofen-stimulated GMBF in a dose-dependent manner, however PYY didn't cause inhibition of pentagastrin- and histamine-induced acid output completely. But PYY had no effect on bethanechol-induced acid output. PYY inhibited the [3H] ACh release from cholinergic nerve endings of gastric body evoked by electrical transmural stimulation. PYY had little effect on gastric vascular perfusion pressure in the basal state, and basal gastric acid output. In the present study, it was concluded that the mechanism of the inhibitory effect of PYY on gastric acid output seems to involve reduced ACh release from cholinergic nerves.
Hashimoto
Y
Y
First Department of Surgery, Kobe University School of Medicine.
Nagahata
Y
Y
Urakawa
T
T
Saitoh
Y
Y
D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D003864:Depression, Chemical; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D008297:Male; D019894:Peptide YY; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D005768:Gastrointestinal Hormones; D010455:Peptides; D019894:Peptide YY; D001418:Baclofen