Propionibacterium acnes-enhanced lens-induced granulomatous uveitis in the rat.
Propionibacterium acnes (Corynebacterium parvum) is being implicated more frequently as a cause of intraocular inflammation following cataract surgery. In addition to its role as an infectious agent, P. acnes also may possess adjuvant-like or adjuvant-enhancing properties. The presence of this organism in an eye with residual lens material after extracapsular cataract surgery could augment inflammation resulting from a phacoantigenic (phacoanaphylactic) response. We have modified an established rat model of lens-induced granulomatous uveitis (LIGU) to examine the adjuvant properties of P. acnes. Our results suggest that P. acnes effectively potentiates LIGU.
Semel
J
J
Doheny Eye Institute, Los Angeles, CA.
Bowe
B
B
Guo
A
A
Lee
L
L
Rife
L
L
Polikoff
D
D
Summanen
P
P
Pararajasegaram
G
G
Finegold
S M
SM
Rao
N
N
D000276:Adjuvants, Immunologic; D000818:Animals; D003459:Crystallins / Q000276:immunology*; D004195:Disease Models, Animal; D005620:Freund's Adjuvant; D006099:Granuloma / Q000276:immunology / Q000473:pathology; D007903:Lens Capsule, Crystalline / Q000601:surgery; D007905:Lens Diseases / Q000276:immunology* / Q000473:pathology; D008297:Male; D011425:Propionibacterium acnes / Q000276:immunology*; D051381:Rats; D014605:Uveitis / Q000276:immunology* / Q000473:pathology
D000276:Adjuvants, Immunologic; D003459:Crystallins; D005620:Freund's Adjuvant