Antitumor-promoting activities of hydrolyzable tannins in mouse skin.
Ellagic acid and gallic acid and its derivatives, applied topically to female CF-1 mice 20 min before each 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment inhibit the inductions of epidermal ornithine decarboxylase activity, hydroperoxide production and DNA synthesis caused by this potent tumor promoter in relation with their abilities to inhibit the promotion of skin papillomas and carcinomas in the two-step initiation-promotion protocol. Because of its potency against TPA promotion, tannic acid, which is already known to inhibit tumor initiation, may inhibit the multistage process of carcinogenesis.
Gali
H U
HU
Division of Biology, Kansas State University, Manhattan 66506-4901.
Perchellet
E M
EM
Klish
D S
DS
Johnson
J M
JM
Perchellet
J P
JP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002277:Carcinoma / Q000139:chemically induced / Q000517:prevention & control; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D051379:Mice; D009955:Ornithine Decarboxylase / Q000096:biosynthesis; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate
D000970:Antineoplastic Agents; D047348:Hydrolyzable Tannins; D006861:Hydrogen Peroxide; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate