title: Triple therapy for advanced squamous cell cancer of the head and neck.
abstract: This study presents the results of treatment for Stage III and IV squamous cell carcinoma of the head and neck at the Princess Alexandra Hospital and Queensland Radium Institute, Brisbane. Patients were treated using a programme of sequential chemotherapy, surgery and radiotherapy. Between 1980 and 1988, 116 patients commenced the programme and 85 completed the treatment as planned. The Price-Hill regimen of chemotherapy was used until 1986 after which time it was replaced by cisplatin/5-fluorouracil (5FU). Two courses were usually given achieving an overall response rate of 36% (12% complete response). Cisplatin/5FU produced an overall response rate of 56% compared with 24% for the Price-Hill regimen. Radical surgical resections were performed using a free flap reconstruction in the majority of patients. Radiotherapy fields usually covered the primary site and both cervical lymph node areas to a dose of 50-60 Gy in 5-6 weeks. The lengthy treatment was generally well tolerated although there were two chemotherapy and two perioperative deaths. The overall actuarial survival for the 85 patients completing the triple therapy was 60%. These patients were analysed in more detail for possible prognostic factors.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors.forename: I M
authors.initials: IM
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Poulsen
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: D
authors.initials: D
authors.lastname: Robinson
authors.forename: D
authors.initials: D
authors.lastname: Thomson
authors.forename: W B
authors.initials: WB
authors.lastname: Coman
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011793:Queensland / Q000453:epidemiology; D011878:Radiotherapy / Q000592:standards*; D012044:Regression Analysis; D013524:Surgical Flaps / Q000592:standards*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil