Analogues of natural phloroglucinols as antagonists against both thromboxane A2 and leukotriene D4.
Antagonists against both thromboxane A2 and leukotriene D4 were prepared from phloroglucinol. These compounds showed almost the same activity as the chinesins which were isolated from Hypericum chinese L. The correlation between the structures and activity was studied in the synthesized and naturally occurring phloroglucinol derivatives.
Tada
M
M
Laboratory of Bio-organic Chemistry, Tokyo University of Agriculture and Technology, Japan.
Chiba
K
K
Takakuwa
T
T
Kojima
E
E
D000818:Animals; D006168:Guinea Pigs; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*; D014132:Trachea / Q000502:physiology
D013189:SRS-A; D013928:Thromboxane A2; D010696:Phloroglucinol