Effect of topical phenylephrine on the permeability of the blood-aqueous barrier in man.
The effects of a single instillation of 5% phenylephrine on aqueous flow and the coefficient of protein entry into the anterior chamber, an index of blood-aqueous barrier permeability, were determined in normal human eyes by measuring fluorescein concentrations with a fluorophotometer and aqueous protein concentrations with a laser flare-cell meter. Both parameters showed a concomitant biphasic change. The coefficient of protein entry showed significant increases of 31 and 66% at 1 and 2 h, and a significant decrease of 18% at 3 h. Aqueous flow showed significant increases of 81 and 125% at 1 and 2 h and a significant decrease of 20% at 4 h. It is suggested that a change in the permeability of the blood-aqueous barrier might be related to changes in aqueous flow after topical phenylephrine.
Araie
M
M
Department of Ophthalmology, University of Tokyo School of Medicine, Japan.
Mori
M
M
Oshika
T
T
D000287:Administration, Topical; D000328:Adult; D001082:Aqueous Humor / Q000378:metabolism*; D001693:Biological Transport, Active; D001769:Blood / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003459:Crystallins / Q000378:metabolism; D019793:Fluorescein; D005452:Fluoresceins / Q000378:metabolism; D015590:Fluorophotometry; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D010656:Phenylephrine / Q000493:pharmacokinetics*; D011680:Pupil / Q000502:physiology
D003459:Crystallins; D005452:Fluoresceins; D010656:Phenylephrine; D019793:Fluorescein