[Preparation of stable W/O/W type multiple emulsion containing water-soluble drugs and in vitro evaluation of its drug-releasing properties].
The stable water-in-oil-in-water (W/O/W) multiple emulsion was prepared by a two-step procedure for emulsification using glyceryl tricaprylate (Panasate-800) as the oil phase. The water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine were selected and entrapped separately in the inner aqueous phase of W/O/W multiple emulsion. In consideration of parenteral administration, pH 7.4 phosphate buffered saline was used in both inner and outer aqueous phases. Moreover, these multiple emulsions could be significantly stable for a month at room temperature by the addition of hydrophilic polymer like gelatin and of amino acid like lysine to the inner aqueous phase.
Zhang
W
W
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Miyakawa
T
T
Uchida
T
T
Goto
S
S
D000675:Ampyrone / Q000008:administration & dosage*; D000983:Antipyrine / Q000008:administration & dosage*; D002434:Cefadroxil / Q000008:administration & dosage*; D002515:Cephradine / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D012995:Solubility; D013696:Temperature; D014867:Water
D004655:Emulsions; D014867:Water; D000675:Ampyrone; D002434:Cefadroxil; D002515:Cephradine; D000983:Antipyrine