Effects of intravesically administered verapamil HC1 (calcium entry blocker) on the bladder function in unanesthetized rats.
The effects of intravesically administered verapamil HCl (calcium entry blocker) on the bladder function were investigated using an experimental model for unanesthetized rats. Intravesical verapamil HCl caused a marked suppression of maximum intravesical pressure accompanied by an increase of residual urine in a dose-dependent manner. The effect almost disappeared 90 min after the elimination of verapamil HCl. It is tentatively suggested that the intravesical instillation of verapamil HCl could be a potent therapy for disorders of bladder function, such as uninhibited contraction.
Ukimura
O
O
Department of Urology, Kyoto Prefectural University of Medicine.
Kojima
M
M
Itoh
H
H
Hosoi
S
S
Watanabe
H
H
D000283:Administration, Intravesical; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects*; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D014700:Verapamil