title: Prevalence of antibodies to recombinant virion infectivity factor in the sera of prospectively studied patients with HIV-1 infection.
abstract: Two hundred twenty-four sera were collected from 34 HIV-1 infected patients during an observation period of up to 4.5 years (109 patient years of observation). The sera were tested for the presence of antibodies against the HIV-1 virion infectivity factor (vif) protein. Thirty sera from 6 HIV-1 seronegative individuals served as negative controls. The sera were immunoblotted against a recombinant, prokaryotically expressed vif protein. The prevalence of anti-vif antibodies increased significantly with progression of the disease from 18% to 81% (P less than 0.0001) which suggests a possible role of vif in HIV-1 replication and pathogenicity.
authors.affiliation: Department of Clinical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schwander
authors.forename: R W
authors.initials: RW
authors.lastname: Braun
authors.forename: J E
authors.initials: JE
authors.lastname: Kühn
authors.forename: F T
authors.initials: FT
authors.lastname: Hufert
authors.forename: P
authors.initials: P
authors.lastname: Kern
authors.forename: M
authors.initials: M
authors.lastname: Dietrich
authors.forename: U
authors.initials: U
authors.lastname: Wieland
mesh_terms: D015415:Biomarkers; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity; D015497:HIV-1; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D015415:Biomarkers; D015483:HIV Antibodies