Influence of treatment with mouse immunoglobulin on the rate of viable neonates in the CBA/J x DBA/2 J model.
In the CBA/J (H-2k) x DBA/2J (H-2d) murine model, the protective value of pooled murine immunoglobulin i.p. was compared with that of serum taken 7 days after termination of CBA/J (H-2k) x BALB/c (H-2d) pregnancy. A control group of CBA/J females received treatment with autologous virgin serum. CBA/J females at 7 weeks of age were injected 3 days before mating with DBA/2J males and 3 days after sighting of the vaginal plug. An effect of treatment can be shown following IgG therapy (P less than 0.05). The highest rate of viable fetuses was documented in the immunoglobulin-treated females, while the rate of viable offspring did not differ in the two serum-treated animal groups.
Heine
O
O
Department of Gynecology and Obstetrics, Justus Liebig University, Giessen, Federal Republic of Germany.
Mueller-Eckhardt
G
G
Stitz
L
L
Pabst
W
W
D000818:Animals; D001667:Binding, Competitive; D003433:Crosses, Genetic; D005260:Female; D005327:Fetal Resorption / Q000235:genetics / Q000276:immunology*; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D011247:Pregnancy
D007136:Immunoglobulins