Clinical and immunologic effects of lipid-based parenteral nutrition in AIDS.
The effect of lipid-based parenteral nutrition was assessed in eight patients with AIDS and weight loss of 10% or greater. All patients received home parenteral nutrition consisting of a lipid-based system with 50% of nonprotein calories given as fat. Measurements were made of body weight, serum albumin, and immune function as assessed by mitogen responses, P24 antigen levels and T-cell counts. Over a period of 2 months, weight gain and improved well-being were noted in all patients. An improved in vitro lymphocyte mitogenic response to phytohemagglutinin and to concanavalin A was also noted. No change in T-cell subsets was observed. Viral cultures and P24 serum levels also remained unchanged. Lipid-based parenteral nutrition is safe and probably efficacious in AIDS.
Singer
P
P
Department of Anesthesiology, Montefiore Medical Center, Bronx, NY 10467.
Rubinstein
A
A
Askanazi
J
J
Calvelli
T
T
Lazarus
T
T
Kirvelä
O
O
Katz
D P
DP
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000628:therapy*; D000328:Adult; D001835:Body Weight; D003208:Concanavalin A / Q000494:pharmacology; D004655:Emulsions; D002149:Energy Intake; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D016331:Parenteral Nutrition, Home; D010743:Phospholipids; D010835:Phytohemagglutinins; D012450:Safflower Oil; D012709:Serum Albumin / Q000378:metabolism; D013024:Soybean Oil
D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; D010835:Phytohemagglutinins; D012709:Serum Albumin; C063336:safflower oil, soybean oil, phospholipid emulsion; D003208:Concanavalin A; D013024:Soybean Oil; D012450:Safflower Oil