A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure.
RK-1409, a new inhibitor of protein kinase C, was isolated from the culture broth of Streptomyces platensis subsp. malvinus RK-1409. The structure was elucidated as 7-oxostaurosporine on the basis of spectroscopic analyses and oxidation of staurosporine.
Koshino
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H
Antibiotics Laboratory, RIKEN, Saitama, Japan.
Osada
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Isono
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K
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013056:Spectrophotometry, Ultraviolet; D019311:Staurosporine / Q000031:analogs & derivatives; D013302:Streptomyces / Q000378:metabolism
D000470:Alkaloids; C073929:7-oxostaurosporine; D011493:Protein Kinase C; D019311:Staurosporine