Minimal residual disease in leukemia: state of the art 1991.
Recent achievements in decreasing the detection level of "minimal residual disease" in leukemia are summarized both in a relevant rat model for acute myelocytic leukemia (BNML) and in the human leukemias. Detection levels as low as 1 leukemic cell per 10(8)-10(9) and 10(5)-10(6) normal bone marrow cells have become realistic in the animal model and in human leukemia, respectively. The implications of these new tools for detecting hidden leukemic cells are discussed.
Hagenbeek
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Institute of Applied Radiobiology and Immunology TNO, Rijswijk, The Netherlands.
D000818:Animals; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis; D002470:Cell Survival; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005819:Genetic Markers; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology; D009929:Organ Size; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000473:pathology; D051381:Rats; D011914:Rats, Inbred BN; D014410:Tumor Stem Cell Assay
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D005819:Genetic Markers