title: Increase of serum somatomedin C in hyperthyroid patients with pregnancy.
abstract: In thyrotoxic women with pregnancy, serum somatomedin C (SmC) concentration was markedly elevated (mean +/- SD 13.57 +/- 4.66 U/ml) compared to thyrotoxic women without pregnancy (1.24 +/- 1.09 U/ml), non-pregnant euthyroid women previously treated for hyperthyroidism (0.87 +/- 0.30 U/ml), normal subjects with pregnancy (6.08 +/- 3.36 U/ml) and pregnant euthyroid women previously treated for hyperthyroidism (5.98 +/- 1.52 U/ml). Since SmC/growth hormone ratio was significantly more in thyrotoxic pregnant women than in normal pregnant women and euthyroid pregnant women previously treated for hyperthyroidism, and since human placental lactogen (HPL), human chorionic gonadotropin (HCG) and prolactin (PRL) do not crossreact with SmC antibody, it is suggested that excess thyroid hormone during pregnancy results in excessive hepatic somatomedin C production.
authors.affiliation: Department of Gerontology, Endocrinology and Metabolism, School of Medicine, Shinshu University, Naganoken, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Shirota
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
authors.forename: M
authors.initials: M
authors.lastname: Ishihara
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: K
authors.initials: K
authors.lastname: Kuma
authors.forename: K
authors.initials: K
authors.lastname: Kamoi
mesh_terms: D000328:Adult; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000150:complications; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood* / Q000150:complications; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D010928:Placental Lactogen / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011863:Radioimmunoassay; D013971:Thyrotoxicosis / Q000097:blood / Q000150:complications
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D010928:Placental Lactogen