Down-regulation of interleukin-2 receptor expression on natural killer cells/large granular lymphocytes by interleukin-4.
It has recently been demonstrated that IL-4 inhibits IL-2 receptor expression on T cells. Studies have also shown that IL-4 can inhibit IL-2-induced natural killer cell (NK) cytotoxicity, and that IL-4 in combination with IL-2 and large granular lymphocyte (NK/LGL) cells suppresses Ig synthesis. Therefore, we examine whether IL-2 receptor expression on NK/LGL cells is affected with or without IL-4, using fluorescent receptor analysis. Our results demonstrate that IL-4 inhibits/down-regulates the expression of IL-2 receptors on either phytohemagglutinin or IL-2-stimulated NK/LGL cells.
Bosse
D
D
Biological Products Branch, Centers for Disease Control, Atlanta, Ga. 30333.
Ades
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E
D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D015536:Down-Regulation / Q000187:drug effects; D006801:Humans; D007376:Interleukin-2 / Q000037:antagonists & inhibitors; D015847:Interleukin-4 / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D015847:Interleukin-4