Localization of the gene for a third G protein beta-subunit to mouse chromosome 6 near Raf-1.
The large family of signal transducing proteins known as G proteins are heterotrimers that dissociate into an independent alpha-subunit and beta gamma-subunit complex after ligand binding or other stimulation. For G alpha, at least 30 distinct sequences representing 10 different classes have been identified. On the other hand, cDNAs for only three G beta-subunit genes have been isolated so far. All three of the G beta genes have been chromosomally mapped in the human, but only two in the mouse. Using a human retinal cDNA for the third G protein beta-subunit, we have mapped the corresponding gene, termed Gnb-3, to mouse Chromosome 6 with somatic cell hybrids and have positioned it distal to but near the marker Raf-1 by analysis of the progeny of three genetic crosses.
Danciger
M
M
Jules Stein Eye Institute, UCLA School of Medicine.
Chakraborti
A
A
Farber
D B
DB
Kozak
C A
CA
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D003433:Crosses, Genetic; D004247:DNA / Q000235:genetics; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D005819:Genetic Markers; D006822:Hybrid Cells; D051379:Mice / Q000235:genetics*; D011487:Protein Conformation
D005819:Genetic Markers; D004247:DNA; D019204:GTP-Binding Proteins