Treatment of acute spinal cord injuries: comparison of thyrotropin-releasing hormone and nimodipine.
The effects of nimodipine and thyrotropin-releasing hormone (TRH) were compared in a clip-compression model of experimental spinal cord injuries (SCI) in rats. Thirty rats received a 50-g clip-compression injury on the cord at T9. Ten rats were given 0.02 mg/kg nimodipine and dextran 40 (3 ml) i.v. 1 h after injury. Ten rats were given 2 mg/kg TRH and dextran 40 (3 ml) i.v. 1 h after injury followed by 1 mg/kg per hour for 4 h. The remaining ten rats were given only saline. TRH treatment significantly improved somatosensory-evoked potentials (SEPs) and mean arterial blood pressures (MABPs), whereas nimodipine treatment had no effect on these variables (Fisher's exact test (P less than 0.01).
Ceylan
S
S
Department of Neurosurgery, KTU Medical Faculty, Trabzon, Turkey.
Ilbay
K
K
Baykal
S
S
Ceylan
S
S
Sener
U
U
Ozmenoğlu
M
M
Kalelioğlu
M
M
Aktürk
F
F
Komsuoğlu
S S
SS
Ozoran
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000378:metabolism; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D009553:Nimodipine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*
D009553:Nimodipine; D013973:Thyrotropin-Releasing Hormone; D002118:Calcium