Hemiballism and chorea in a patient with parkinsonism due to a multisystem degeneration.
Dyskinesias associated with dopaminergic treatment in idiopathic Parkinson's disease (PD) can be indistinguishable from those arising spontaneously in other conditions involving degeneration of, or damage to, the basal ganglia. However, those due to levodopa treatment of PD disappear on cessation of therapy. We report a patient with a clinical diagnosis of PD who, on levodopa treatment, developed hemiballism and chorea that were originally thought to be drug induced. However, the dyskinesias persisted despite stopping levodopa. Postmortem analysis showed a multisystem degeneration.
Steiger
M J
MJ
Department of Clinical Neurology, Institute of Neurology, London, U.K.
Pires
M
M
Scaravilli
F
F
Quinn
N P
NP
Marsden
C D
CD
D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002230:Carbidopa / Q000009:adverse effects / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000150:complications* / Q000473:pathology; D002819:Chorea / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D003937:Diagnosis, Differential; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D009069:Movement Disorders / Q000209:etiology* / Q000473:pathology; D009410:Nerve Degeneration / Q000502:physiology; D010300:Parkinson Disease / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology
D000978:Antiparkinson Agents; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa