The lysine analog L-oxalysine is an inhibitor of RNA synthesis.
1. The lysine analog L-4-oxalysine was found to be a potent inhibitor of RNA synthesis in Candida albicans. 2. The compound was a weak inhibitor of protein synthesis and DNA synthesis was not affected. 3. The inhibition of RNA synthesis was reversed by L-lysine but not D-lysine. 4. The decrease in the level of newly synthesized RNA in cells treated with L-oxalysine was due to inhibition of de novo synthesis rather than to degradation of RNA.
Zheng
H
H
Department of Microbiology, University of Tennessee, Knoxville 37901.
Zhang
H L
HL
Becker
J M
JM
Naider
F
F
Farkas
W R
WR
D000596:Amino Acids / Q000494:pharmacology; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D004271:DNA, Fungal / Q000096:biosynthesis; D004587:Electrophoresis, Agar Gel; D005656:Fungal Proteins / Q000096:biosynthesis; D007700:Kinetics; D008239:Lysine / Q000031:analogs & derivatives*; D012331:RNA, Fungal / Q000096:biosynthesis*
D000596:Amino Acids; D000600:Amino Acids, Dicarboxylic; D004271:DNA, Fungal; D005656:Fungal Proteins; D012331:RNA, Fungal; C027136:4-oxalysine; D008239:Lysine