[Genetic abnormalities in "sporadic" colorectal cancers].
There are many genetic abnormalities in colorectal cancers, and they can schematically be studied according to 3 approaches. 1. The quantitative abnormalities of the DNA content of the nucleus and the cell cycle are studied with flow cytometry. 2. Karyotypic abnormalities relating to the loss and/or gain of chromosomes or structural abnormalities are studied by cytogenetics. 3. Oncogene or anti-oncogene mutations carried out by these chromosomal segments are studied by molecular biology. When compared to the clinical data, some of these abnormalities have a prognostic value. They allow an insight into the fundamental mechanisms of colorectal carcinogenesis. Finally, they may allow predicting and assessing the efficacy of some adjunctive therapies, especially that of medication.
Salmon
R J
RJ
Institut Curie, Paris.
Remvikos
Y
Y
Muleris
M
M
Thomas
G
G
D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D015179:Colorectal Neoplasms / Q000235:genetics*; D003582:Cytogenetics; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D005434:Flow Cytometry; D016163:Genes, DCC / Q000235:genetics; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D008967:Molecular Biology; D009857:Oncogenes / Q000235:genetics*; D011003:Ploidies; D011379:Prognosis
D004273:DNA, Neoplasm
Anomalies génétiques dans les cancers colo-rectaux "sporadiques".