Correlation of serum concentrations of ibuprofen stereoisomers with clinical response in the treatment of hip and knee osteoarthritis.
Stereoselective pharmacokinetic measurements of the active enantiomer, S-ibuprofen, were correlated with clinical response in 45 participants in a randomized double blinded 4 week comparison of ibuprofen, 1200 or 2400 mg/day, for treatment of hip or knee osteoarthritis. Ibuprofen dose correlated with S-ibuprofen area under the serum concentration curve (AUC), trough and average concentration, but not with clinical outcome. AUC of S-ibuprofen correlated with improvement in disability, rest pain and in the physician's global assessment (p = 0.02, 0.08, and 0.10, respectively), and negatively with the subject's weight and creatinine clearance (p = 0.09 and 0.07, respectively). Some individual variation in responsiveness to ibuprofen (and other nonsteroidal antiinflammatory drugs) may be attributed to pharmacokinetic differences.
Bradley
J D
JD
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202-5103.
Rudy
A C
AC
Katz
B P
BP
Ryan
S I
SI
Kalasinski
L A
LA
Brater
D C
DC
Hall
S D
SD
Brandt
K D
KD
D000328:Adult; D004185:Disability Evaluation; D005260:Female; D006621:Hip Joint; D006801:Humans; D007052:Ibuprofen / Q000097:blood / Q000627:therapeutic use*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010003:Osteoarthritis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D012649:Self Concept; D013237:Stereoisomerism; D011795:Surveys and Questionnaires
D007052:Ibuprofen