title: Measurement of serum haptoglobin as an indicator of the efficacy of malaria intervention trials.
abstract: Serum haptoglobin levels were measured by an enzyme-linked immunosorbent assay in Gambian children who participated in 3 malaria intervention trials with untreated or impregnated bed nets. In one study, in which a significant effect on clinical malaria was observed, the mean serum haptoglobin level was significantly higher in the intervention than in the control group. In the other 2 studies, in which no significant protection was observed, mean haptoglobin levels were similar in intervention and control groups. Measurement of serum haptoglobin may provide a useful indirect measure of the effectiveness of malaria control programmes.
authors.affiliation: Medical Research Council Laboratories, Fajara, Banjul, The Gambia.
authors.forename: F
authors.initials: F
authors.lastname: Sisay
authors.forename: P
authors.initials: P
authors.lastname: Byass
authors.forename: R W
authors.initials: RW
authors.lastname: Snow
authors.forename: B M
authors.initials: BM
authors.lastname: Greenwood
authors.forename: L H
authors.initials: LH
authors.lastname: Perrin
authors.forename: S
authors.initials: S
authors.lastname: Yerly
mesh_terms: D001512:Bedding and Linens; D002648:Child; D002675:Child, Preschool; D005260:Female; D005714:Gambia; D006242:Haptoglobins / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007300:Insect Control; D007306:Insecticides; D008288:Malaria / Q000097:blood* / Q000517:prevention & control*; D008297:Male; D026023:Permethrin; D011722:Pyrethrins
chemical_list: D006242:Haptoglobins; D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin