Expression of IL-2 receptor/p75 on lymphocytes from patients with rubella.
We analyzed the Interleukin-2 receptor (IL-2R) expression on fresh lymphocytes from three patients with rubella. Flow cytometric analysis demonstrated that lymphocytes from the patients expressed a considerable amount of IL-2R/p75 recognized by Mik-beta 1 monoclonal antibody (MoAb), although they did not react with anti-IL-2R/p55 (CD25) MoAb. The expression of IL-2R/p75 reached a peak at the end of the acute phase of illness. Fresh lymphocytes from rubella patients showed a marked proliferative response to IL-2, which was completely inhibited by Mik-beta 1, indicating that their IL-2R is a functional receptor. The present data suggest that IL-2R/p75 expression is involved in the host immune response triggered by the rubella virus.
Komada
Y
Y
Department of Pediatrics, Mie University School of Medicine, Japan.
Oitani
K
K
Zhou
Y W
YW
Zhang
S L
SL
Sakurai
M
M
D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000378:metabolism*; D012409:Rubella / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015375:Receptors, Interleukin-2