title: [Nephrolithiasis and bone involvement in primary hyperparathyroidism. The relative role of vitamin D].
abstract: In order to analyze the role of 1,25(OH)2 D3 in bone and renal presentation forms of primary hyperparathyroidism (PHP), 61 patients, whose diagnosis had been confirmed surgically, were studied. An increase in serum 1,25(OH)2 D3 levels was found in PHP when compared to normal controls (49.1 +/- 2.8 pg/ml vs 34.1 +/- 1.4 pg/ml) (p less than 0.5). This increase directly correlates with serum alkaline phosphatase and creatinine clearance and inversely correlates with age. When patients were divided into two groups: A (n = 35) and B (n = 26) according to normal or increased 1,25(OH)2 D3 respectively, no difference was found in the clinical presentation forms of PHP. However, higher values of the biochemical parameters and bone remodeling markers were found in group B than in group A. This suggests the role of 1,25(OH)2 D3 as a modulator of metabolic activity in PHP and its possible therapeutic character in the clinical control of asymptomatic forms.
authors.affiliation: Servicio de Medicina Interna, Fundación Jiménez Díaz, Madrid.
authors.forename: A
authors.initials: A
authors.lastname: Díez Labajo
authors.forename: M L
authors.initials: ML
authors.lastname: Traba
authors.forename: A
authors.initials: A
authors.lastname: Rapado
authors.forename: M V
authors.initials: MV
authors.lastname: Alvarez Arroyo
authors.forename: B
authors.initials: B
authors.lastname: Peramo
authors.forename: M
authors.initials: M
authors.lastname: Díaz Curiel
authors.forename: C
authors.initials: C
authors.lastname: de la Piedra
authors.forename: J L
authors.initials: JL
authors.lastname: Calleja
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D002117:Calcitriol / Q000097:blood*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D006961:Hyperparathyroidism / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D007669:Kidney Calculi / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D002117:Calcitriol
vernacular_title: Nefrolitiasis y participación ósea en el hiperparatiroidismo primario. Papel relativo de la vitamina D.