title: Effect of period of exposure on the developmental toxicity of butyl benzyl phthalate in rats.
abstract: The objective of the present study was to determine if periods of exposure would modify the developmental toxicity of butyl benzyl phthalate (BBP). Pregnant Wistar rats were given BBP at a dose of 2.0% in the diet on days 0-20, days 0-7, days 7-16 or days 16-20 of pregnancy. Food consumption and body weight gain were decreased in the pregnant rats given BBP. All dams given BBP on days 0-20 exhibited complete resorption of all the implanted embryos. Post-implantation loss in the pregnant rats given BBP on days 0-7 or 7-16 was higher than that in the control and pair-fed pregnant rats. No increase in post-implantation loss was found in the pregnant rats given BBP on days 16-20. Pre-implantation loss in the BBP-treated groups was comparable to the control and pair-fed groups. Striking teratogenicity was detected in fetuses of the dams given BBP on days 7-16. Cleft palate and fusion of the sternebrae were predominantly observed. About 95% of the fetuses in this group had cleft palate. The incidence of malformations in this group was significantly and markedly higher than that in the control and pair-fed groups.
authors.affiliation: National Institute of Hygienic Sciences, Osaka Branch, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ema
authors.forename: T
authors.initials: T
authors.lastname: Itami
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001842:Bone and Bones / Q000002:abnormalities; D003338:Corpus Luteum / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D010064:Embryo Implantation / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D007682:Kidney Pelvis / Q000002:abnormalities; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D010795:Phthalic Acids; C027561:butylbenzyl phthalate