[Significance of ultraviolet light in the pathogenesis of systemic lupus erythematosus: case report and discussion of the literature].
A 33-year-old woman with a 9-year history of psoriasis developed a severe SLE with no signs of visceral involvement during a 3-week exposure to PUVA (psoralen and UVA) therapy. The patient fulfilled the criteria of the American Rheumatism Association (25) for the diagnosis of SLE. She showed dermatological lesions including facial erythema, photo-sensibility arthritis, hematological disorders including leuko-, lympho-, thrombocytopenia, antinuclear antibodies, and dsDNA antibodies. With a therapy that included corticosteroids, chloroquine, and azathioprine the disease could be controlled. The coincidence of a PUVA therapy and the first flare-up of an SLE demonstrates a possible pathogenic role of UV light in SLE.
Pirner
K
K
Medizinische Klinik III mit Poliklinik, Universität Erlangen-Nürnberg.
Rubbert
A
A
Salinger
R
R
Kalden
J R
JR
Manger
B
B
D001706:Biopsy; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000139:chemically induced / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000473:pathology; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology
Bedeutung des UV-Lichtes in der Pathogenese des SLE: Kasuistik und Diskussion der Literatur.