Evoked potentials (EPs) in experimental allergic encephalomyelitis: a study of EP modifications during the course of a controlled disease.
24 juvenile strain 13 guinea pigs were sensitized with homologous spinal cord homogenate in complete Freund's adjuvant in order to obtain Experimental Allergic Encephalomyelitis (EAE) in the Chronic Relapsing (CR-EAE), Chronic Progressive (CP-EAE) and Acute (A-EAE) forms. Visual, Brain-Stem Acoustic, Somatosensory Evoked Potentials were recorded in these animals, prior to the sensitizing injection and during the course of the disease. The aim of our study was to observe modifications of Evoked Potentials during progression of a demyelinating disease. Latency delays of Evoked Potentials appeared 15 days after the sensitizing injection, preceding or simultaneously with clinical alterations and when demyelinated plaques were not detected in anatomical specimens.
Onofrj
M
M
Department of Neurology, Università Statale G. D'Annunzio, Facoltà di Medicina e Chirurgia, Chieti, Italy.
Gambi
D
D
Bazzano
S
S
Colamartino
P
P
Fulgente
T
T
Malatesta
G
G
Ferracci
F
F
D000208:Acute Disease; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000473:pathology / Q000503:physiopathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000473:pathology / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D006168:Guinea Pigs; D009103:Multiple Sclerosis / Q000473:pathology / Q000503:physiopathology; D011930:Reaction Time; D013116:Spinal Cord / Q000473:pathology