title: Cytokine responses to cardiopulmonary bypass with membrane and bubble oxygenation.
abstract: The systemic inflammatory response to cardiopulmonary bypass was assessed in 20 patients who underwent elective coronary artery bypass grafting with flat-sheet membrane oxygenation (group I; n = 10; age, 59 +/- 5 years) or bubble oxygenation (group II; n = 10; age, 62 +/- 8 years). The duration of cardiopulmonary bypass was 46 +/- 12 minutes in group I and 47 +/- 15 minutes in group II. Plasma interleukin-6, plasma interleukin-1 beta, transpulmonary leukocyte counts, pulmonary hemodynamic variables, and respiratory index were determined in all patients perioperatively. The plasma interleukin-6 response (median [range]) was similar in both groups at the end of the operation, peaked 4 hours postoperatively (99 [30 to 320] pg/mL in group I; 123 [21 to 300] pg/mL in group II; p greater than 0.05), and remained elevated 48 hours postoperatively (76 [9 to 140] pg/mL in group I; 65 [25 to 159] pg/mL in group II; p greater than 0.05). No significant interleukin-1 beta response was demonstrated. Pulmonary neutrophil and lymphocyte sequestration was observed on commencement of cardiopulmonary bypass in group II but did not occur in either group on discontinuation of cardiopulmonary bypass. Pulmonary vascular resistance at the end of the operation (82 [48 to 320] dynes.s.cm-5 in group I; 119 [54 to 385] dynes.s.cm-5 in group II; p greater than 0.05) was similar to preoperative values (151 [30 to 327] dynes.s.cm-5 in group I; 185 [62 to 291] dynes.s.cm-5 in group II; p greater than 0.05). The respiratory index at the end of the operation was similarly and significantly increased in both groups (1.26 [0.92 to 4.17] in group I; 1.44 [0.73 to 3.30] in group II).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Cardiothoracic Surgery, Oxford Heart Centre, England.
authors.forename: J
authors.initials: J
authors.lastname: Butler
authors.forename: G L
authors.initials: GL
authors.lastname: Chong
authors.forename: R J
authors.initials: RJ
authors.lastname: Baigrie
authors.forename: R
authors.initials: R
authors.lastname: Pillai
authors.forename: S
authors.initials: S
authors.lastname: Westaby
authors.forename: G M
authors.initials: GM
authors.lastname: Rocker
mesh_terms: D000368:Aged; D001998:Bronchopulmonary Sequestration; D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010107:Oxygenators, Membrane; D011652:Pulmonary Circulation; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6