Recombinant interleukin-1 alpha, interleukin-2 and M-CSF-1 enhance the survival of newborn C57BL/6 mice inoculated intraperitoneally with a lethal dose of herpes simplex virus-1.
Recombinant Interleukin-1 alpha (IL-1 alpha), Interleukin-2 (IL-2) and recombinant macrophage colony-stimulating factor-1 (M-CSF-1) as well as combinations of IL-2 and M-CSF-1 were studied for their ability to protect seven-day-old C57BL/6 mice against HSV-1 infection. Treatment of the mice with IL-2, M-CSF-1 or combinations of IL-2 and M-CSF-1 significantly increased survival rates. Treatment with IL-1 alpha (10 U and 100 U/mouse) was most effective in protection against HSV-1, resulting in significantly increased survival rates more than four times greater than the survival rate of the infected control group.
Berkowitz
C
C
Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Becker
Y
Y
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000382:microbiology; D004195:Disease Models, Animal; D006561:Herpes Simplex / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D007375:Interleukin-1 / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000627:therapeutic use*; D016173:Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D011994:Recombinant Proteins / Q000627:therapeutic use; D016019:Survival Analysis; D015996:Survival Rate
D007375:Interleukin-1; D007376:Interleukin-2; D011994:Recombinant Proteins; D016173:Macrophage Colony-Stimulating Factor