Oxidative damage to human plasma proteins by ozone.
Exposure of human plasma to ozone produces oxidative protein damage, measured as protein carbonyl formation. Isolated human albumin or creatine phosphokinase are oxidized much faster than are total proteins. Consideration must be given to proteins as targets of oxidative injury by ozone in vivo.
Cross
C E
CE
Department of Medicine, University of California, Davis Medical Center, Sacramento 95817.
Reznick
A Z
AZ
Packer
L
L
Davis
P A
PA
Suzuki
Y J
YJ
Halliwell
B
B
D000328:Adult; D001798:Blood Proteins / Q000187:drug effects* / Q000378:metabolism; D003402:Creatine Kinase / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010126:Ozone / Q000009:adverse effects*; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism
D001798:Blood Proteins; D005609:Free Radicals; D012709:Serum Albumin; D010126:Ozone; D003402:Creatine Kinase