title: The International Cooperative Study on the Timing of Aneurysm Surgery. The North American experience.
abstract: OBJECTIVE
  The timing of aneurysm surgery after subarachnoid hemorrhage is a major neurosurgical controversy addressed by the International Cooperative Study on the Timing of Aneurysm Surgery (1980-1983). The present report examines the results of this trial in the subgroup of patients admitted to North American centers.
  
  
  METHODS
  The method of study was a large, multicenter, prospective, epidemiological survey. Neurosurgeons were required to indicate prospectively the interval to planned aneurysm surgery at the time of patient admission. Outcome at 6 months was determined by a blinded evaluator, and overall management results were analyzed by the planned surgical interval.
  
  
  RESULTS
  Seven hundred seventy-two (21.9% of the total study population) patients admitted from days 0 to 3 after subarachnoid hemorrhage were accrued in North American centers. Overall outcome in patients planned for surgery in days 0-3 was equivalent in terms of mortality (after adjustment for prognostic variables) to patients planned for days 11-32, but the early patients had significantly improved rates of good recovery (70.9% versus 61.7%, p less than 0.01). Patients planned for surgery during the days 7-10 interval had nearly twice the mortality of patients in the other intervals.
  
  
  CONCLUSIONS
  In contrast to the results from the overall trial, which found no difference between early and delayed surgery, results were best in North American centers when surgery was planned between days 0 and 3 after subarachnoid hemorrhage. These findings argue strongly for early diagnosis and referral for surgical intervention of North American patients suspected of having a ruptured cerebral aneurysm.
authors.affiliation: Department of Neurology, University of Virginia School of Medicine, Charlottesville.
authors.forename: E C
authors.initials: EC
authors.lastname: Haley
authors.forename: N F
authors.initials: NF
authors.lastname: Kassell
authors.forename: J C
authors.initials: JC
authors.lastname: Torner
mesh_terms: D000328:Adult; D002533:Cerebral Angiography; D004812:Epidemiologic Methods; D005260:Female; D006306:Health Surveys; D006801:Humans; D007391:International Cooperation; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009656:North America; D011182:Postoperative Care; D011183:Postoperative Complications; D011300:Preoperative Care; D011446:Prospective Studies; D016019:Survival Analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed