EDTA treatment of intermittent claudication--a double-blind, placebo-controlled study.
A double-blind, randomized multicentre study was undertaken to evaluate the possible effect of chelation treatment with ethylenediamine-tetraacetic acid (EDTA) in patients with severe intermittent claudication. A total of 153 patients received 20 intravenous infusions of either 3 g Na2EDTA or placebo during a period of 5-9 weeks. Vitamin, mineral and trace element supplements were administered orally. The changes observed in the pain-free and maximal walking distances, measured on a treadmill, were similar in the two groups. During the 3-month (n = 149) and 6-month (n = 123) follow-up period, no long-term therapeutic effect of EDTA could be demonstrated. The ankle-brachial blood pressure index remained unchanged throughout the study period. This study failed to demonstrate any effect of EDTA chelation treatment in intermittent claudication.
Guldager
B
B
Department of Surgery, Central Hospital Hillerød, Denmark.
Jelnes
R
R
Jørgensen
S J
SJ
Nielsen
J S
JS
Klaerke
A
A
Mogensen
K
K
Larsen
K E
KE
Reimer
E
E
Holm
J
J
Ottesen
S
S
D000368:Aged; D000704:Analysis of Variance; D004311:Double-Blind Method; D004492:Edetic Acid / Q000627:therapeutic use*; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007383:Intermittent Claudication / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016138:Walking
D004492:Edetic Acid