title: Enhancement of bone bonding to bioactive ceramics by demineralized bone powder.
abstract: In an attempt to enhance the bonding of bone to bioactive ceramics, allogeneic demineralized bone powder (DBP) was used in combination with bioactive ceramic implants in rabbit tibiae. Rectangular plates (10 x 15 x 2 mm) made of apatite-wollastonite-containing glass ceramics were implanted in the proximal metaphyses of the bilateral tibiae of 20 rabbits, with DBP packed into the medullary cavity. In the control group, only the plates of A-W GC were implanted in the bilateral tibiae of 20 rabbits. Four rabbits from each group were killed at two, four, eight, 12, and 25 weeks after implantation for the tensile test. Results of the tensile test and histologic examination of the undecalcified specimens by Giemsa surface stain and contact microradiography confirmed that DBP significantly accelerated the process of bone bonding to the implant and increased the strength of bone-implant bonding.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kotani
authors.forename: T
authors.initials: T
authors.lastname: Yamamuro
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Kitsugi
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Kawanabe
authors.forename: T
authors.initials: T
authors.lastname: Kokubo
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins; D002516:Ceramics / Q000378:metabolism*; D006133:Growth Substances / Q000378:metabolism*; D016348:Osseointegration; D019736:Prostheses and Implants; D011506:Proteins / Q000378:metabolism*; D011817:Rabbits; D013718:Tensile Strength; D013977:Tibia / Q000166:cytology; D016474:Weight-Bearing
chemical_list: D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D011506:Proteins