Glucose administration combined with photodynamic therapy of cancer improves therapeutic efficacy.
Both the scope and the levels of activity in basic research and in the clinical applications of PDT, have grown enormously during the past few years. Several studies have examined the synergism of hyperthermia and chemotherapeutic agents in combination with PDT to enhance tumor eradication. The present study investigates the synergism of glucose administration combined with phototherapy. The results of this study suggest that glucose administration is simple and well tolerated, and combined with PDT produces a larger percentage of animals cured than using PDT alone. Furthermore, the results indicate that this approach requires lower amounts of light and might enable dosage reduction of photosensitizer for optimal response, with minimal side effects, to the treatment of cancer.
Nelson
J S
JS
Beckman Laser Institute and Medical Clinic, University of California, Irvine 92715.
Kimel
S
S
Brown
L
L
Berns
M W
MW
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D053685:Laser Therapy; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D010778:Photochemotherapy / Q000379:methods*; D012074:Remission Induction
D005947:Glucose