title: Bone mineral content in patients with primary hyperparathyroidism: a comparison of conservative management with surgical treatment.
abstract: The management of patients with asymptomatic hyperparathyroidism remains controversial. This study examined the extent to which the presence of prospect of bone disease should influence treatment. Bone mineral content (BMC) of the distal forearm was measured by single photon absorptiometry in 67 patients with mild hyperparathyroidism. Twenty-six patients treated surgically and 17 managed conservatively were reviewed regularly for up to 4 years. Eighty per cent of patients had a baseline fat-corrected BMC within the local reference interval for age and sex, but about 75 per cent of values fell below the mean. BMC at the 'distal' site of the surgically treated patients improved or stabilized, but a continuing decline was seen in the patients managed conservatively (P less than 0.01). Differences were small and concern about future osteoporotic fracture should seldom be a major factor in making decisions about surgical correction of mild hyperparathyroidism.
authors.affiliation: Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Mole
authors.forename: M H
authors.initials: MH
authors.lastname: Walkinshaw
authors.forename: A
authors.initials: A
authors.lastname: Gunn
authors.forename: C R
authors.initials: CR
authors.lastname: Paterson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005542:Forearm; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008593:Menopause / Q000502:physiology; D008875:Middle Aged; D016105:Parathyroidectomy; D013997:Time Factors