Tianeptine, a specific serotonin uptake enhancer, decreases ethanol intake in rats.
The effect on ethanol intake of the selective 5-HT uptake enhancer tianeptine was examined in rats and compared with that of fluoxetine, a specific 5-HT uptake inhibitor. Both treatments significantly decreased ethanol intake (54% by tianeptine and 57% by fluoxetine). Fluoxetine also decreased food intake whereas tianeptine did not. Body weight was decreased by 12.5% in fluoxetine-treated rats but was not modified by tianeptine. It is proposed that tianeptine has a specific action on ethanol intake, possibly related to its effect on serotonin function.
Daoust
M
M
Faculté de Médecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Compagnon
P
P
Legrand
E
E
Mocaër
E
E
D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D013841:Thiazepines / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D011985:Receptors, Serotonin; D013841:Thiazepines; D005473:Fluoxetine; C050504:tianeptine