title: Rapid screening for bacteriuria in pregnancy.
abstract: We evaluated a bioluminescence assay as a screening test for the detection of bacteriuria in pregnancy. A total of 1,000 urine specimens from a randomly selected group of pregnant women undergoing prenatal surveillance was investigated. Sequential dilution of urine specimens on CLED agar plates served as a reference method. Set against the reference group, bioluminescence screening scored a 93% sensitivity, a 78% specificity and a 99% predictive accuracy for negative results. All urine specimens were also analysed chemically for the presence of nitrite and leucocyte esterase by dip sticks. Dip sticks proved to be insufficient because of poor sensitivities of 54% and 59%, respectively. The bioluminescence assay is an effective, time- as well as labor-saving but questionably cost-effective method for the detection of bacteriuria in pregnancy.
authors.affiliation: Universitätsklinik für Chemotherapie, Wien, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Graninger
authors.forename: D
authors.initials: D
authors.lastname: Fleischmann
authors.forename: B
authors.initials: B
authors.lastname: Schneeweiss
authors.forename: L
authors.initials: L
authors.lastname: Aram
authors.forename: F
authors.initials: F
authors.lastname: Stockenhuber
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D001437:Bacteriuria / Q000517:prevention & control / Q000652:urine*; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008403:Mass Screening / Q000379:methods*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000652:urine*; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D000255:Adenosine Triphosphate