Chronic progressive CNS histoplasmosis presenting in childhood: response to fluconazole therapy.
An 18-year-old Hispanic female developed symptoms of a Histoplasma capsulatum infection at 9 1/2 years of age. Initial problems of ataxia and hydrocephalus were followed by seizures and a cranial nerve palsy which developed over several years. T1-weighted cranial magnetic resonance imaging studies revealed numerous high-signal lesions; subsequently, signs of multisystem dissemination developed. Treatment included ventriculoperitoneal shunting, corticosteroids, amphotericin B, and a new antifungal agent, fluconazole, which was responsible for marked improvement.
Rivera
I V
IV
Department of Neurology, University of Miami School of Medicine, Florida.
Curless
R G
RG
Indacochea
F J
FJ
Scott
G B
GB
D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy*; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009460:Neurologic Examination
D015725:Fluconazole