Galacardins A and B, new glycopeptide antibiotics.
A strain of actinomycetes identified as Saccharothrix sp. SANK 64289 was found to produce new antibiotics, galacardins A and B. Their physico-chemical properties showed that they were new members of glycopeptide antibiotics. They were structurally related to beta-avoparcin but differed from it only in sugar composition. Though beta-avoparcin does not contain galactose, galacardins A and B did contain two and one moles of galactose, respectively. They showed strong antimicrobial activity against Gram-positive bacteria and also showed excellent in vivo protective activity against Staphylococcus aureus infection in mice.
Takeuchi
M
M
Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Takahashi
S
S
Enokita
R
R
Sakaida
Y
Y
Haruyama
H
H
Nakamura
T
T
Katayama
T
T
Inukai
M
M
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D006020:Glycopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006020:Glycopeptides; C074357:galacardin B; C074356:galacardin A