Salmonella typhimurium enterotoxin mediated fluid secretion.
Unidirectional Na+ and Cl- fluxes were studied in rats treated with S. typhimurium enterotoxin (S-LT). There was net absorption of Na+ and Cl- in the control group, while in the toxin treated animals there was net secretion of Na+ and Cl- (P less than 0.001). There was no change in the transport of D-glucose in the toxin treated group as compared to the control animals. The Na+, K(+)-ATPase pump was unaltered in the S-LT treated animals (198.67 +/- 11.23 nmoles Pi/mg protein/min) as compared to the control group (189.93 +/- 10.09 nmoles Pi/mg protein/min). There was no change in the unidirectional fluxes of Ca+2 in the S-LT treated animals as compared to the control animals, suggesting no change in the permeability of the S-LT treated intestinal membrane to Ca+2.
Khurana
S
S
Department of Experimental Medicine, Postgraduate Institute of Medical Education & Research, Chandigarh.
Ganguly
N K
NK
Panigrahi
D
D
Khullar
M
M
Walia
B N
BN
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D002118:Calcium / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D004731:Endotoxins; D004768:Enterotoxins / Q000633:toxicity*; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D001427:Bacterial Toxins; D002712:Chlorides; D004731:Endotoxins; D004768:Enterotoxins; C027952:salmonella toxin; D012964:Sodium; D002118:Calcium