Fate of conidia of Paracoccidioides brasiliensis after ingestion by resident macrophages or cytokine-treated macrophages.
Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice significantly inhibited transformation of ingested conidia.
Cano
L E
LE
Corporacion para Investigaciones Biologicas, Hospital Pablo Tobon Uribe, Medellin, Colombia.
Brummer
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E
Stevens
D A
DA
Restrepo
A
A
D000818:Animals; D000941:Antigens / Q000276:immunology; D016207:Cytokines / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology; D008264:Macrophages / Q000382:microbiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010228:Paracoccidioides / Q000254:growth & development*; D013154:Spleen / Q000502:physiology
D000941:Antigens; D016207:Cytokines; D007371:Interferon-gamma