[Activities of antithrombin III and heparin cofactor II in patients with pathologic blood coagulation conditions].
To investigate the physio-pathological functions of HC-II, assays for HC-II and AT-III were performed simultaneously on the samples from patients with DIC, liver dysfunction or renal disease from the three view points of consumption, production and loss of AT-III and HC-II. For the AT-III activity, two kinds of assays were applied: the automatic chromogenic substrate method and a newly developed clotting method which receives no effects from HC-II activity. The activity of HC-II was significantly lower than that of AT-III in patients with either DIC or liver dysfunction. However, no significant difference between HC-II and AT-III activities in patients with either thrombosis or renal disease. There were high correlations between HC-II and AT-III activities were found in the patients with liver dysfunction, suggesting that low activity was due to decreased production of HC-II and AT-III in the liver. It will be necessary that elucidation of the significant functions of HC-II not only in coagulation and hemostasis but also in regulation of local inflammation and invasion of neoplasm is necessary.
Hirokawa
S
S
Second Department of Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University.
Kaji
T
T
Tazawa
K
K
Fujimaki
M
M
Hayashi
T
T
Niiya
K
K
Sakuragawa
N
N
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism*; D004211:Disseminated Intravascular Coagulation / Q000097:blood*; D015844:Heparin Cofactor II / Q000378:metabolism*; D006801:Humans; D007674:Kidney Diseases / Q000097:blood; D008107:Liver Diseases / Q000097:blood*; D008875:Middle Aged
D015844:Heparin Cofactor II; D000990:Antithrombin III