[The effective antibacterial spectrum of sulfacetamide].
Swabs of the anterior eye segment of 180 eyes (145 patients) taken in the time period between August 1, 1989 until August 30, 1989 were sent to an external, independent microbiological institute in order to verify in-vitro antibacterial properties of marketed sulfacetamide containing drugs. MIC test was performed with isolated pathogenic bacterial strains without knowledge of the underlying diagnosis. It was shown that sulfacetamide is able to inhibit the growth of all isolated strains. Depending on the type of bacteria concentrations of 0.006 up to 6.4% sodium sulfacetamide proved to be effective. Simultaneously, all patients were treated with sulfacetamide containing ointment and/or eye drops 4 times daily for maximum of 14 days. With swabs taken at intervals of 7 and 14 days no bacterial growth was detected.
Roth
H W
HW
Institut für wissenschaftliche Kontaktoptik, Ulm.
Leimbeck
R
R
Sonnenschein
B
B
Anger
C B
CB
Weber
S
S
D001419:Bacteria / Q000187:drug effects; D001762:Blepharitis / Q000188:drug therapy* / Q000382:microbiology; D003234:Conjunctivitis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D013409:Sulfacetamide / Q000008:administration & dosage*
D009883:Ophthalmic Solutions; D013409:Sulfacetamide
Zum antibakteriellen Wirkungsspektrum von Sulfacetamid.