title: Relationship between angiographic infarct size and left ventricular filling.
abstract: Infarct size may influence left ventricular filling after acute myocardial infarction. Pulsed Doppler transmitral flow velocities were compared in 47 patients at 7 +/- 6 days following acute myocardial infarction and 47 age-matched controls. Patients were stratified by angiographic infarct size into Groups I, II, III (corresponding angiographic hypokinetic scores less than 2; 2-2.99; greater than or equal to 3 SD/cord). Early diastolic transmitral Doppler flow velocities did not differ between infarct groups but atrial transmitral Doppler flow measurements did: peak A velocity (p = 0.001), A velocity time integral (p less than 0.001), and total velocity time integral (p = 0.001). Compared to controls atrial transmitral Doppler flow was augmented in Group I, whilst atrial and total transmitral Doppler flow were depressed in Group III. Peak A velocity and A velocity time integral were inversely related to infarct size (R = -0.44 to -0.54) and directly to left ventricular ejection fraction (R = 0.59 to 0.65). Large infarct size following myocardial infarction is associated with lower atrial and total transmitral Doppler flow velocities.
authors.affiliation: Department of Cardiology and Health Information Systems, Royal North Shore Hospital, St Leonards, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Cranswick
authors.forename: R
authors.initials: R
authors.lastname: Davis
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: S N
authors.initials: SN
authors.lastname: Hunyor
mesh_terms: D000328:Adult; D000368:Aged; D016280:Atrial Function, Right; D017023:Coronary Angiography; D003326:Coronary Circulation; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D013318:Stroke Volume; D016277:Ventricular Function, Left