A novel variant of human interferon alpha 1 gene.
A 520-base pair human IFN-alpha gene was isolated by PCR method twice from chromosome DNA of a Chinese (Han Nationality) fetal liver. The nucleotide sequences were determined. These two separately amplified DNA fragments shared the completely identical nucleotide sequence but possessed C and G at positions 410 and 541, respectively, which differ from those of IFN-alpha 1 and IFN-alpha D previously described. Therefore the deduced amino acid sequence would have an Ala at position 114 and a Val at position 158. At all other sites it has the same amino acids as those in IFN-alpha 1 and IFN-alpha D. We recommend that IFN-alpha D gene, IFN-alpha I gene and IFN-alpha I/158V gene found in our laboratory, be named IFN-alpha 1a gene, IFN-alpha 1b gene and IFN-alpha 1c gene.
Li
M F
MF
Institute of Virology, Chinese Academy of Preventive Medicine, Beijing.
Jin
Q
Q
Hu
G
G
Guo
H Y
HY
Hou
Y D
YD
D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005333:Fetus; D005796:Genes; D006801:Humans; D016898:Interferon-alpha / Q000235:genetics*; D008099:Liver / Q000166:cytology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction
D016898:Interferon-alpha; D004247:DNA