The effect of combinations of ampligen and zidovudine or dideoxyinosine against human immunodeficiency viruses in vitro.
The combinations of ampligen and zidovudine at ratios of 100:1, 25:1, 10:1, and 1:50 acted synergistically to reduce cytopathology caused by HIV in MT-2 cell cultures. Combination indices were less than 1 at all of these ratios representing different combinations of concentrations and at 3 effective doses (ED30, ED50, ED70). Combination of drugs which show synergism at a wide range of ratios of combinations suggest that they may be useful clinically, and that the antiviral efficacy of ZDV may be increased in combination with ampligen. Synergism was also found between ampligen and zidovudine by reduction of HIV-produced plaques in a HeLa cell line expressing CD-4 receptors. However the combination of ampligen and dideoxyinosine against HIV in MT-2 cells was only additive and not synergistic.
O'Marro
S D
SD
AIDS Clinical Trials Unit, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Armstrong
J A
JA
Asuncion
C
C
Gueverra
L
L
Ho
M
M
D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D016049:Didanosine / Q000494:pharmacology*; D004357:Drug Synergism; D006678:HIV / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D011070:Poly I-C / Q000494:pharmacology*; D011072:Poly U / Q000494:pharmacology*; D015215:Zidovudine / Q000494:pharmacology*
D000998:Antiviral Agents; D011072:Poly U; D015215:Zidovudine; C047490:poly(I).poly(c12,U); D016049:Didanosine; D011070:Poly I-C