Increase of extracellular acetylcholine level in rat frontal cortex induced by (+)N-allylnormetazocine as measured by brain microdialysis.
Acute administration of (+)N-allylnormetazocine ((+) SKF-10,047) was found to increase the extracellular acetylcholine (ACh) level in rat frontal cortex, as measured by brain microdialysis in freely-moving rats. The increase elicited by (+)SKF-10,047 was dose-dependent and the increase was significant at a dose of 5.0 mg/kg, compared with the saline-treated group. On the other hand, the extracellular dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) level in the frontal cortex was not changed by (+)SKF-10,047 at 5.0 mg/kg, whereas extracellular ACh level increased markedly in this area. These results suggest that (+)SKF-10,047 can affect some central nervous system (CNS) functions through the increment of extracellular ACh level in rat frontal cortex at lower doses.
Matsuno
K
K
Central Research Laboratories, Santen Pharmaceutical Co. Ltd., Osaka, Japan.
Matsunaga
K
K
Mita
S
S
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D003956:Dialysis; D005110:Extracellular Space / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism*; D008297:Male; D010620:Phenazocine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D015102:3,4-Dihydroxyphenylacetic Acid; C012134:SK&F 10047; D010620:Phenazocine; D000109:Acetylcholine