Expression of alpha-melanocyte stimulating hormone and the invasive ability of the B16 murine melanoma.
The expression of alpha melanocyte stimulating hormone (MSH) has been investigated in two variants of the B16 murine melanoma. The presence of MSH was demonstrated by immunohistochemical methods using anti-MSH antibodies. The low metastasis variant B16-F1, which grows as an encapsulated non-invasive tumour, showed no alpha-MSH immunoreactivity. In contrast, the high metastasis variant BL6 was found to be alpha-MSH positive and the immunoreactivity was found predominantly in the peripheral invading zones of the tumour.
Zubair
A
A
Cancer Research Unit, Medical School, University of Newcastle upon Tyne, U.K.
Lakshmi
M S
MS
Sherbet
G V
GV
D000818:Animals; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis*; D008546:Melanoma, Experimental / Q000737:chemistry / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009361:Neoplasm Invasiveness
D009074:Melanocyte-Stimulating Hormones