title: Maculopathy caused by intra-arterially administered cisplatin and intravenously administered carmustine.
abstract: Eight patients with malignant gliomas were monitored with clinical examinations to study the effects of the combination of intravenous administration of carmustine and infraophthalmic intra-arterial administration of cisplatin on retinal and optic nerve function. Three patients developed a severe macular retinal pigment abnormality in the eye ipsilateral to the intra-arterial infusion. Electrophysiologic studies disclosed no evidence of a generalized disturbance in the photoreceptors, middle retinal layers, or retinal pigment epithelium. In contrast to previous studies involving patients whose visual loss was caused by vaso-occlusive lesions in the retina and optic nerve, our study involved patients with clinically significant maculopathy, that was not vascular in origin and that developed after treatment with carmustine and cisplatin. We suggest that the deficit may result from a localized retinal pigment disturbance in the macula.
authors.affiliation: Department of Ophthalmology, New York University Medical Center, New York.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kupersmith
authors.forename: W H
authors.initials: WH
authors.lastname: Seiple
authors.forename: K
authors.initials: K
authors.lastname: Holopigian
authors.forename: K
authors.initials: K
authors.lastname: Noble
authors.forename: E
authors.initials: E
authors.lastname: Hiesiger
authors.forename: F
authors.initials: F
authors.lastname: Warren
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D002330:Carmustine / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D004594:Electrophysiology; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005910:Glioma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007275:Injections, Intravenous; D008266:Macula Lutea; D008875:Middle Aged; D012164:Retinal Diseases / Q000139:chemically induced*
chemical_list: D002945:Cisplatin; D002330:Carmustine