title: Maturation and insulin-like immunoreactivity in rat submandibular salivary glands: possible implication of G regulatory proteins.
abstract: Streptozotocin-induced diabetes is accompanied by an increase in insulin-like immunoreactivity concentration in rat submandibular salivary glands. In this study we have examined whether, in normal state, maturation is accompanied by changes in insulin-like immunoreactivity concentration of rat submandibular salivary glands. Insulin-like immunoreactivity concentrations of submandibular salivary glands were significantly higher in 11 months old rats compared with 3.5 months old control animals. A pertussis toxin pretreatment provoked an increase in insulin-like immunoreactivity, suggesting that a pertussis toxin sensitive G-protein is involved in the regulation of insulin-like immunoreactivity in the rat submandibular salivary glands.
authors.affiliation: Facility of Dental Surgery, Laboratory of Physiology, Montpellier, France.
authors.forename: D
authors.initials: D
authors.lastname: Deville de Périère
authors.forename: R
authors.initials: R
authors.lastname: Puech
authors.forename: D
authors.initials: D
authors.lastname: Hillaire-Buys
authors.forename: G
authors.initials: G
authors.lastname: Ribes
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D007328:Insulin / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D013363:Submandibular Gland / Q000254:growth & development / Q000378:metabolism*
chemical_list: D007328:Insulin; D019204:GTP-Binding Proteins