title: Influence of local anaesthesia and local hypothermia on leucocyte, temperature, and transferrin response to surgery.
abstract: Leucocyte counts, rectal temperature, P-cortisol, P-glucose, P-transferrin, P-orosomucoid, P-IgM and hematocrit were investigated in 24 men undergoing inguinal herniotomy. The patients were randomised to epidural analgesia (n = 8), local infiltration anaesthesia (n = 8) or local infiltration anaesthesia plus local wound hypothermia with ice bags (n = 8). The rectal temperature rose (p less than 0.01) in patients randomised to epidural analgesia but not in the other groups. However, blood granulocyte and acute phase protein changes were similar in all groups. The neural blockade was sufficient in all patients as judged by lack of increase in P-cortisol and P-glucose. Thus, local infiltration anaesthesia and wound hypothermia could not prevent the inflammatory response to small clean surgery.
authors.affiliation: Department of Surgical Gastroenterology, Herlev Hospital, Copenhagen.
authors.forename: S
authors.initials: S
authors.lastname: Schulze
authors.forename: B
authors.initials: B
authors.lastname: Rye
authors.forename: I W
authors.initials: IW
authors.lastname: Møller
authors.forename: H
authors.initials: H
authors.lastname: Kehlet
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000772:Anesthesia, Local; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D001831:Body Temperature / Q000502:physiology*; D006098:Granulocytes / Q000502:physiology; D006400:Hematocrit; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007036:Hypothermia, Induced; D007962:Leukocytes / Q000502:physiology*; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy; D013514:Surgical Procedures, Operative; D014168:Transferrin / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D014168:Transferrin; D006854:Hydrocortisone