title: Platelet-derived growth factor in Dupuytren's disease.
abstract: This study investigated whether platelet-derived growth factor, a potent inducer of cell proliferation, was identifiable in association with myofibroblasts in Dupuytren's disease. Myofibroblasts in the hypercellular disease stages showed a strong reaction to platelet-derived growth factor antibody using light and electron microscopic immunochemical labels. Platelet-derived growth factor may play a role as a cellular signal for myofibroblast proliferation in the formation of the pathognomonic nodule in Dupuytren's disease.
authors.affiliation: Department of Orthopaedics, School of Medicine, State University of New York, Stony Brook 11794-8181.
authors.forename: M A
authors.initials: MA
authors.lastname: Badalamente
authors.forename: L C
authors.initials: LC
authors.lastname: Hurst
authors.forename: S K
authors.initials: SK
authors.lastname: Grandia
authors.forename: S P
authors.initials: SP
authors.lastname: Sampson
mesh_terms: D000328:Adult; D000368:Aged; D002455:Cell Division; D004387:Dupuytren Contracture / Q000378:metabolism / Q000473:pathology*; D005205:Fascia / Q000737:chemistry / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000737:chemistry / Q000473:pathology; D006225:Hand; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000032:analysis*
chemical_list: D010982:Platelet-Derived Growth Factor