title: Integrating chromosome structure with function.
abstract: Historically, the metaphase chromosome and its architecture has been viewed as the ultimate representation of a non-functional inactive chromatin state. Recent studies of centromere (kinetochore) function in concert with studies of the placement and function of several classes of chromosomal proteins now call for a reevaluation of this view. In this article a model of chromosome structure with functional correlates is presented. Evidence for the existence of a functional chromosomal region, the "Surface Domain" is discussed.
authors.affiliation: Department of Anatomy and Medical Biochemistry, University of Calgary, Alberta, Canada.
authors.forename: J B
authors.initials: JB
authors.lastname: Rattner
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology; D002875:Chromosomes / Q000502:physiology* / Q000648:ultrastructure*; D006801:Humans