title: The effect of intramedullary polymethylmethacrylate on healing of intercalary cortical allografts in a canine model.
abstract: The purpose of this study was to evaluate the effect of intramedullary polymethylmethacrylate (PMMA) bone cement on the healing of intercalary allografts. Thirteen adult beagles had bilateral intercalary femoral allografts implanted. The medullary canal of one randomly assigned allograft in each dog was filled with PMMA. Healing was followed clinically and femora were evaluated radiographically, biomechanically, histologically, and histomorphometrically 9 months after surgery. There was an increased percent of eroded surface at the endosteal area of the center region of grafts containing PMMA and there was an increased percent osteoblast surface in this area in grafts not containing PMMA. There was an increased percent eroded surface at the periosteal area in the center region in grafts not containing PMMA and there was an increased percent osteoblast surface at the periosteal area in the graft adjacent to the host junction in grafts containing PMMA. There was no significant difference between PMMA-treated and untreated allografts in any other parameters measured. The results from this study suggest that, although the pattern of incorporation is altered, intramedullary PMMA does not appear to effect allograft healing adversely.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
authors.forename: R C
authors.initials: RC
authors.lastname: Straw
authors.forename: B E
authors.initials: BE
authors.lastname: Powers
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow
authors.forename: M F
authors.initials: MF
authors.lastname: Cooper
authors.forename: A S
authors.initials: AS
authors.lastname: Turner
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001843:Bone Cements / Q000494:pharmacology; D016025:Bone Transplantation / Q000379:methods*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000378:metabolism / Q000494:pharmacology*; D008954:Models, Biological; D010006:Osteoblasts / Q000187:drug effects / Q000502:physiology; D011859:Radiography; D014184:Transplantation, Homologous / Q000379:methods*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001843:Bone Cements; D008768:Methylmethacrylates; D020366:Methylmethacrylate