title: P300 as indicator of effects of prophylactic cranial radiation.
abstract: In order to assess the late adverse effects of cranial radiation on the central nervous system, 33 children with acute lymphocytic leukemia were examined through event-related potential P300, brain response analysis. P300 latency was significantly prolonged in children who received both prophylactic cranial radiation and intrathecal methotrexate. Although a longitudinal study is necessary, we believe that P300 is useful in the assessment of the adverse effects of cranial radiation in children with acute lymphocytic leukemia.
authors.affiliation: Department of Pediatrics, Jichi Medical School, Tochigi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Miyao
authors.forename: H
authors.initials: H
authors.lastname: Muchi
authors.forename: Y
authors.initials: Y
authors.lastname: Gunji
authors.forename: A
authors.initials: A
authors.lastname: Iizuka
authors.forename: M
authors.initials: M
authors.lastname: Yanagisawa
mesh_terms: D000161:Acoustic Stimulation; D001143:Arousal / Q000187:drug effects / Q000528:radiation effects*; D001921:Brain / Q000528:radiation effects*; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000175:diagnosis*; D002540:Cerebral Cortex / Q000187:drug effects / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004569:Electroencephalography / Q000187:drug effects / Q000528:radiation effects*; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000139:chemically induced / Q000175:diagnosis*; D011879:Radiotherapy Dosage; D011930:Reaction Time / Q000187:drug effects / Q000528:radiation effects; D012307:Risk Factors
chemical_list: D008727:Methotrexate