title: Risk factors for tumors of the brain and meninges: results from the Adelaide Adult Brain Tumor Study.
abstract: A population-based case-control study of incident primary brain tumors in adults was carried out in Adelaide, Australia in the period 1987 through 1990. It included 110 subjects with newly diagnosed primary glioma, 60 subjects with meningioma and 417 controls selected from the Australian Electoral Roll and frequency-matched to cases for age (within 2 years), sex and postal code. Some interesting new associations were found: (1) an increased risk of glioma in women who reported working with cathode-ray tubes (relative risk = 4.1, 95% confidence interval: 1.3-13.2); (2) a decreased risk of glioma in those with a history of allergic diseases (relative risk = 0.5, 95% confidence interval: 0.3-0.9); and (3) an increased risk of meningioma in those exposed to passive smoking from a spouse, especially amongst females (relative risk = 2.7, 95% confidence interval: 1.2-6.1). A pooled analysis of the multi-center group of studies to which the present study belongs should allow more confident claims concerning risk factors for brain tumors.
authors.affiliation: SEARCH Programme, Unit of Analytic Epidemiology, International Agency for Research on Cancer, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Ryan
authors.forename: M W
authors.initials: MW
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: North
authors.forename: A J
authors.initials: AJ
authors.lastname: McMichael
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects; D001315:Australia / Q000453:epidemiology; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D004232:Diuretics / Q000009:adverse effects; D055590:Electromagnetic Phenomena; D004781:Environmental Exposure; D006633:Histamine Antagonists / Q000009:adverse effects; D006801:Humans; D008577:Meningeal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology; D009603:Nitroso Compounds / Q000009:adverse effects; D012307:Risk Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014881:Water Supply
chemical_list: D004232:Diuretics; D006633:Histamine Antagonists; D009603:Nitroso Compounds; D014028:Tobacco Smoke Pollution