title: A potential animal model for studying CF heterozygote advantage: genetic variation in theophylline-inducible colonic chloride currents among inbred strains of mice.
abstract: We have used Ussing chambers to measure chloride secretion by colonic segments (mucosa, muscularis, and serosa) from various inbred strains of mice. We found lower theophylline-induced Cl- secretion in the DBA/2J than in the C57BL/6J strain. Their F1 showed significantly higher levels of Cl- secretion than did the C57BL/6J parental strain while colonic segments from five recombinant inbred B x D lines ranged between the C57BL/6J and F1 values. No major component of the variation appeared to be associated with alleles of the met oncogene region of chromosome 6 or the H-2 region of chromosome 17.
authors.affiliation: Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor 48109.
authors.forename: A
authors.initials: A
authors.lastname: Sweet
authors.forename: R P
authors.initials: RP
authors.lastname: Erickson
authors.forename: C
authors.initials: C
authors.lastname: Huntington
authors.forename: D
authors.initials: D
authors.lastname: Dawson
mesh_terms: D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D003550:Cystic Fibrosis / Q000235:genetics*; D004195:Disease Models, Animal; D004553:Electric Conductivity; D005260:Female; D014644:Genetic Variation; D006579:Heterozygote; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019859:Proto-Oncogene Proteins c-met; D013806:Theophylline / Q000494:pharmacology
chemical_list: D002712:Chlorides; D011518:Proto-Oncogene Proteins; D013806:Theophylline; D019859:Proto-Oncogene Proteins c-met