title: Synthesis and optical resolution of an antiallergic agent KW4099 with thromboxane A2 antagonistic activity.
abstract: A new antiallergic agent with thromboxane A2 antagonistic activity, KW4099, was synthesized by a simple method. Its optical resolution was accomplished with the use of (+)- or (-)-2,2'-(1,1'-binaphthyl)phosphoric acid as a resolving agent.
authors.affiliation: Sakai Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sugaya
authors.forename: Y
authors.initials: Y
authors.lastname: Kuge
authors.forename: S
authors.initials: S
authors.lastname: Tomioka
authors.forename: K
authors.initials: K
authors.lastname: Tamaki
mesh_terms: D003990:Dibenzoxepins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006967:Hypersensitivity / Q000188:drug therapy; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors*
chemical_list: D003990:Dibenzoxepins; D010880:Piperidines; C074371:KW 4099; D013928:Thromboxane A2