title: Hemorrhage induces c-fos immunoreactivity in spinally projecting neurons of cat subretrofacial nucleus.
abstract: Neuronal expression of c-fos product in the cat rostral ventrolateral medulla was studied by immunohistochemistry. Spinally projecting neurons of the subretrofacial (SRF) nucleus were pre-labeled by retrograde transport of fluorescent latex microspheres from the lumbar cord. In 3 animals which were bled by approximately 25% blood volume from a carotid cannula, 48-62% of SRF-spinal neurons expressed c-fos immunoreactivity. In 2 control animals, the corresponding values were 2% and 4%. The data show that bulbospinal neurons of presumed vasomotor function express c-fos in response to hemorrhage.
authors.affiliation: Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
authors.forename: R M
authors.initials: RM
authors.lastname: McAllen
authors.forename: E
authors.initials: E
authors.lastname: Badoer
authors.forename: A D
authors.initials: AD
authors.lastname: Shafton
authors.forename: B J
authors.initials: BJ
authors.lastname: Oldfield
authors.forename: M J
authors.initials: MJ
authors.lastname: McKinley
mesh_terms: D000818:Animals; D002415:Cats; D002543:Cerebral Hemorrhage / Q000378:metabolism*; D008526:Medulla Oblongata / Q000378:metabolism* / Q000473:pathology; D009434:Neural Pathways / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D013116:Spinal Cord / Q000473:pathology
chemical_list: D016760:Proto-Oncogene Proteins c-fos