A simplified approach to in vitro fertilization.
A simplified protocol for in vitro fertilization treatment was developed using low-dose clomiphene for ovarian stimulation, timing of human chorionic gonadotropin administration based solely on sonographic criteria, in-office egg retrieval and use of a simplified culture medium for embryo culture. Twenty-six infertile women underwent 39 treatment cycles, with 33 egg retrievals resulting in 29 embryo transfers. Clinical pregnancy was obtained in six patients (20.7% per embryo transfer), for a rate comparable to that achieved with conventional in vitro fertilization treatment in an age-matched control group. This simplification of in vitro fertilization treatment protocols can lead to decreased patient stress and costs without a substantially lower success rate.
Steinkampf
M P
MP
Department of Obstetrics and Gynecology, University of Alabama, Birmingham School of Medicine, AL 35294.
Kretzer
P A
PA
McElroy
E
E
Conway-Myers
B A
BA
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use; D002985:Clinical Protocols / Q000592:standards*; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use; D004624:Embryo Transfer / Q000379:methods / Q000592:standards; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D010062:Ovulation Induction / Q000379:methods / Q000592:standards; D011247:Pregnancy; D011256:Pregnancy Outcome
D006063:Chorionic Gonadotropin; D002996:Clomiphene