Inhibition of interferon gamma production by peripheral blood mononuclear leukocytes of patients with sarcoidosis. Pathogenic implications.
Interferon gamma (IFN-gamma) production by stimulated peripheral mononuclear leukocytes of 30 patients with sarcoidosis was studied. A significant inhibition (64 percent, 5 to 330 IU/ml vs normal individuals = 1,000 +/- 250 IU/ml) in the IFN-gamma synthesis was found. The inhibition is due to a defect in the circulating monocytes and not in the peripheral T lymphocytes of these patients. This defect in the peripheral IFN-gamma production could be involved in the pathogenesis of this disease.
Bertrán
G
G
Departamento de Sustancias Vasoactivas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Arzt
E
E
Resnik
E
E
Mosca
C
C
Nahmod
V
V
D001681:Biological Assay / Q000379:methods; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000037:antagonists & inhibitors* / Q000097:blood / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism*; D008171:Lung Diseases / Q000097:blood* / Q000209:etiology; D010835:Phytohemagglutinins; D012507:Sarcoidosis / Q000097:blood* / Q000209:etiology
D010835:Phytohemagglutinins; D007371:Interferon-gamma