title: Large artery dilation produced by converting enzyme inhibition in hypertension: therapeutic aspects.
abstract: Large artery dilation is produced by angiotensin-converting enzyme inhibition in hypertensive subjects despite a significant blood pressure reduction. The resulting increase in arterial compliance may be due both to blood pressure decrease and to arterial smooth muscle relaxation. In healthy volunteers and in hypertensive subjects, dosages causing large artery dilation seem to be higher than those causing pure arteriolar dilation with resulting blood pressure reduction. Similar findings have been noted to obtain compliance enhancement. Such results may be important in considering antihypertensive therapy, particularly when remodeling of the cardiovascular system is considered in long-term treatment.
authors.affiliation: Department of Internal Medicine, Hôpital Broussais, Paris, France.
authors.forename: M E
authors.initials: ME
authors.lastname: Safar
authors.forename: R G
authors.initials: RG
authors.lastname: Asmar
authors.forename: A
authors.initials: A
authors.lastname: Benetos
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D001916:Brachial Artery / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors