title: Lanomycin and glucolanomycin, antifungal agents produced by Pycnidiophora dispersa. I. Discovery, isolation and biological activity.
abstract: The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14 alpha-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, N.J. 08543-4000.
authors.forename: J
authors.initials: J
authors.lastname: O'Sullivan
authors.forename: D W
authors.initials: DW
authors.lastname: Phillipson
authors.forename: D R
authors.initials: DR
authors.lastname: Kirsch
authors.forename: S M
authors.initials: SM
authors.lastname: Fisher
authors.forename: M H
authors.initials: MH
authors.lastname: Lai
authors.forename: W H
authors.initials: WH
authors.lastname: Trejo
mesh_terms: D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D004875:Ergosterol / Q000096:biosynthesis; D005260:Female; D005285:Fermentation; D051379:Mice; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011714:Pyrans; C074358:lanomycin; C074359:glucolanomycin; D004875:Ergosterol