The role of radiation therapy in the management of spinal cord compression due to extramedullary haematopoiesis in thalassaemia.
Extramedullary haematopoiesis associated with thalassaemia leading to spinal cord compression is an extremely rare event in the course of the disease. The efficacy of radiation therapy is advocated in the management of such a complication. Two patients with thalassaemia, who had presented with spinal cord compression, were successfully treated by a modest dose of local radiotherapy. In one of the patients, however, radiotherapy was resorted to after an initial decompressive laminectomy and partial removal of the intraspinal haematopoietic mass proved unsuccessful. The other patient was managed solely by radiation therapy.
Singhal
S
S
Department of Radiation Oncology and Neurosurgery, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi.
Sharma
S
S
Dixit
S
S
De
S
S
Chander
S
S
Rath
G K
GK
Mehta
V S
VS
D000328:Adult; D003131:Combined Modality Therapy; D006411:Hematopoiesis, Extramedullary / Q000502:physiology / Q000528:radiation effects*; D006413:Hematopoietic System / Q000473:pathology; D006801:Humans; D007796:Laminectomy; D008297:Male; D009460:Neurologic Examination; D013116:Spinal Cord / Q000473:pathology; D013117:Spinal Cord Compression / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D013789:Thalassemia / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery