Role of cell growth factor (interleukin-2) and its receptors in carcinoma cervix patients.
Host immunity plays an important role in neoplasia. Neoplastic activity is known to correspond with the disturbances in immunological mechanisms. T-lymphocytes DNA replication and mitosis are determined by a critical threshold of signals generated by the interaction between interleukin-2 (IL-2) and its receptors. So we planned to study the level of IL-2 in carcinoma cervix patients. Twenty healthy (normal) and fifty carcinoma cervix patients were investigated. The level of IL-2 was estimated by thymidine incorporation [Anderson et al., Eur. J. Immun. 9 (1979) 581-587]. A remarkable decrease in concentration of IL-2 in serum of the patients (mean = 21.62 U/100 microliters) when compared with normal healthy individuals (36.86 U/100 microliters). Immunotherapy in the form of IL-2 can be suggested in such patients.
Rani
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Anatomy Department, All India Institute of Medical Sciences, New Delhi.
Vaidya
M C
MC
Rani
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D000328:Adult; D004261:DNA Replication; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D015375:Receptors, Interleukin-2 / Q000032:analysis*; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000473:pathology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2