[An HLA-B27 negative case of ankylosing spondylitis with acute iridocyclitis].
The author experienced a 34-year-old male case of acute iridocyclitis with fibrinous exudates accompanied by ankylosing spondylitis with negative HLA-B27. Who was diagnosed definite ankylosing spondylitis by the New York criteria. The cause of ankylosing spondylitis was postulated to be a cross reaction between HLA-B27 and a certain Gram-negative bacillus. However, our case with negative HLA-B27 suggested the causes could comprise multiple factors in addition to HLA-B27. Since the clinical picture of iridocyclitis observed in our case showed no difference with those of HLA-B27 positive cases, iridocyclitis associated with ankylosing spondylitis is considered to be the same entity regardless of HLA-B27 being present or not.
Yoshikawa
M
M
Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
Nakamura
S
S
Ohno
S
S
D000208:Acute Disease; D000328:Adult; D015796:HLA-B27 Antigen / Q000378:metabolism*; D006801:Humans; D015863:Iridocyclitis / Q000209:etiology*; D008297:Male; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000276:immunology
D015796:HLA-B27 Antigen