Cocaine, social behavior, and alcohol-solution drinking in monkeys.
Eight group-living male monkeys received cocaine (0 to 3.0 mg/kg) individually or as a group. Cocaine suppressed social affiliative behaviors, eating, and drinking (of both alcohol and control solutions). It induced bizarre stereotypies, hypervigilance, panic-like fleeing, enhancement and then suppression of locomotion, and a seizure. Cocaine had little effect on aggressiveness or sexual behavior. Proportion of time spent lying or sitting changed significantly. Cocaine produced severe behavioral abnormality in this social setting.
Crowley
T J
TJ
Department of Psychiatry, University of Colorado School of Medicine, Denver 80262.
Mikulich
S K
SK
Williams
E A
EA
Zerbe
G O
GO
Ingersoll
N C
NC
D000378:Agonistic Behavior / Q000187:drug effects; D000428:Alcohol Drinking / Q000523:psychology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D006608:Hierarchy, Social; D007273:Injections, Intramuscular; D008251:Macaca; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012919:Social Behavior; D012931:Social Environment
D003042:Cocaine