title: Review of chemical and UV light-induced melanomas in experimental animals in relation to human melanoma incidence.
abstract: In a few epidemiological studies on oil refinery workers, a slight excess of melanoma incidence has been reported. To see if this might be linked to exposure to polycyclic aromatic hydrocarbons (PAHs) contained in refinery streams, a review of animal data on the relationship between PAH exposure, UV light and melanoma induction has been carried out and compared with human data. This revealed that the highly carcinogenic PAH 7,12-dimethylbenz[a]anthracene (DMBA) was capable of inducing melanomas in hamsters, mice and guinea pigs, but only under certain experimental conditions. Evidence suggested that other carcinogenic PAHs were unable to induce melanomas. As high dose levels of DMBA were generally required to produce melanomas, it was not considered that the amounts present in refinery streams would be sufficient to account for an increase in melanoma incidence in exposed workers. This conclusion was substantiated by the failure of petroleum-derived complex hydrocarbon mixtures to produce melanomas in animals or man and by drawing attention to the absence of any association between melanoma incidence and the incidence of other skin cancers in man. If PAHs were responsible for an increase in melanoma incidence, an increase in other skin tumours would also be expected. It was concluded that animal data, taken in conjunction with other information, do not suggest that PAH exposure is likely to be the cause of any elevation in melanoma incidence in refinery workers. More detailed epidemiological findings would be required to establish whether any excess incidence of melanomas was due to sunlight, other risk factors or chance occurrences.
authors.affiliation: BP International Limited, Group Occupational Health Centre, Guildford, Surrey, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Ingram
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D006801:Humans; D015994:Incidence; D008545:Melanoma / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D008546:Melanoma, Experimental / Q000139:chemically induced / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D016273:Occupational Exposure; D011083:Polycyclic Compounds / Q000633:toxicity; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D011083:Polycyclic Compounds; D015127:9,10-Dimethyl-1,2-benzanthracene