Total lymphoid irradiation in chronic progressive multiple sclerosis.
6 patients with severe chronic progressive multiple sclerosis were subjected to total lymphoid irradiation (TLI) to assess clinical efficacy and side effects. During a 4 year follow-up the disability progression was continuous. Side effects during TLI were well tolerated; side effects after TLI brought about a worsening of the quality of life. One patient died of pneumonia. In this preliminary study TLI did not reduce the worsening of disability in MS patients.
Capra
R
R
Clinica Neurologica, Università di Brescia.
Marcianó
N
N
Mattioli
F
F
Di Monda
V
V
Vignolo
L A
LA
Buffoli
A
A
Micheletti
E
E
Magno
L
L
D000328:Adult; D002908:Chronic Disease; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008208:Lymphatic System; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology / Q000532:radiotherapy*