title: The influence of single topical application of dichlorvos on blood esterases and toxicity in male calves.
abstract: The effect of dichlorvos on inducing changes in blood esterase activities and systemic toxicity was investigated following single topical applications of 1, 3 or 6% dichlorvos concentrations to male calves. Dichlorvos at 1% concentration did not produce any signs of toxicity, whereas 3 and 6% concentrations induced mild to severe toxicity characteristic of anticholinesterase poisoning. Dichlorvos at all concentrations significantly inhibited erythrocyte cholinesterase (25-75%), plasma cholinesterase (30-85%), and serum carboxylesterase (15-51%) activities in male calves. The dose-dependent inhibition was maximum 12 h after insecticide exposure. The extent of inactivation of blood esterases was not correlated with the severity of toxicity. Inhibition of blood cholinesterases by the 6% dichlorvos was still present 21 d after the dichlorvos exposure.
authors.affiliation: Department of Pharmacology, Bangladesh Agricultural University, Mymensingh.
authors.forename: M
authors.initials: M
authors.lastname: Abdul Awal
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D002417:Cattle / Q000502:physiology*; D002802:Cholinesterases / Q000097:blood*; D004006:Dichlorvos / Q000633:toxicity*; D008297:Male
chemical_list: D004006:Dichlorvos; D002265:Carboxylic Ester Hydrolases; D002802:Cholinesterases