title: 1991 Labat Lecture. The effect of local anesthetics on the peripheral vasculature.
abstract: The effects of local anesthetic agents on the peripheral vasculature are not uniform and not easily described. Factors governing these effects are as follows: the method of application (i.e., intravenously, intraarterially, or locally): When injected into the venous system, a stimulating effect (central nervous system effect) is usual, which dominates over a peripheral vasoconstriction effect; the concentration: Resistance to flow is reduced with high concentrations and vasoconstriction occurs with low concentrations; the target organ (e.g., skin, placenta, lungs, splanchnic bed, and spinal cord), which is significant; an anti-adrenaline-like effect; isomers, which can differ in their effect (mepivacaine, not bupivacaine). With these final comments I would like to conclude this presentation. I hope that it has been as stimulating for you as an audience as it has been for me in preparing it. I would again like to express my deep and sincere gratitude for the honor you have bestowed upon me and for the kind attention you have devoted to my lecture.
authors.affiliation: Department of Anaesthesiology, Linköping University, Sweden.
authors.forename: J B
authors.initials: JB
authors.lastname: Löfström
mesh_terms: D000776:Anesthesiology / Q000266:history; D000779:Anesthetics, Local / Q000494:pharmacology*; D001363:Awards and Prizes; D001783:Blood Flow Velocity / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D049673:History, 20th Century; D006801:Humans; D012955:Societies, Medical; D014481:United States; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D000779:Anesthetics, Local