title: Mechanical properties and histology of charge modified bioprosthetic tissue resistant to calcification.
abstract: Modification of bioprosthetic heart valves tissue by covalently binding protamine sulphate, results in stable covalent links of protamine to the tissue, conferring resistance to calcification. We report here the morphological evaluation and mechanical properties (elastic modulus and ultimate tensile strength) of protamine-bound bioprosthetic tissue that have high anticalcification potential. Protamine-bound bioprosthetic tissue had significantly higher tissue modulus and ultimate tensile strength values than control tissue groups. However, the mechanical properties and tissue architecture were inferior to those of bioprosthetic tissue.
authors.affiliation: Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Golomb
authors.forename: I
authors.initials: I
authors.lastname: Lewinstein
authors.forename: V
authors.initials: V
authors.lastname: Ezra
authors.forename: F J
authors.initials: FJ
authors.lastname: Schoen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001705:Bioprosthesis; D002114:Calcinosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002417:Cattle; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D008422:Materials Testing; D010496:Pericardium; D011479:Protamines; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D011479:Protamines