A case of primary biliary cirrhosis associated with Hashimoto's thyroiditis, scleroderma and Sjögren's syndrome.
A 53-year-old woman was admitted because of Raynaud's phenomenon, polyarthralgia and polymyalgia. Biopsy specimens of the liver and thyroid gland revealed characteristic findings of primary biliary cirrhosis (PBC) (stage I by Scheuer's classification) and chronic thyroiditis. Her clinical features were also complicated by scleroderma (type I by Barnett's classification) and Sjögren's syndrome (Sjs) with keratoconjunctivitis sicca. Thyroid hormone replacement therapy led to improvement in thyroid function, normalization of the biliary tract enzymes and alleviation of subjective symptoms.
Horita
M
M
First Department of Internal Medicine, Medical College of Oita, Japan.
Takahashi
N
N
Seike
M
M
Nasu
S
S
Takaki
R
R
D001323:Autoantibodies / Q000097:blood; D001659:Biliary Tract / Q000201:enzymology; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000201:enzymology / Q000473:pathology; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000150:complications*; D012859:Sjogren's Syndrome / Q000150:complications*; D013967:Thyroiditis, Autoimmune / Q000150:complications* / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies