title: Alveolar haemorrhage with pleural effusion as a manifestation of epithelioid haemangioendothelioma.
abstract: A 22 year old male was admitted with haemoptysis. A chest X-ray showed bilateral confluent alveolar infiltrates. Bronchoscopy revealed blood oozing from all bronchopulmonary segments. Open lung biopsy disclosed bilateral effusions and large necrotizing nodules with pleural adhesions. Histological examination showed tumour cells, which were negative to epithelial and embryogenic markers but positive to factor VIII. This confirmed the diagnosis of an epithelioid haemangioendothelioma. This rare tumour, usually has an indolent course, whereas in our case it was complicated by alveolar and intrapleural bleeding.
authors.affiliation: Pulmonary and Allergic Diseases Institute, Ichilov Medical Center, Tel-Aviv, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Struhar
authors.forename: P
authors.initials: P
authors.lastname: Sorkin
authors.forename: J
authors.initials: J
authors.lastname: Greif
authors.forename: S
authors.initials: S
authors.lastname: Marmor
authors.forename: E
authors.initials: E
authors.lastname: Geller
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D006390:Hemangioendothelioma / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis; D006469:Hemoptysis / Q000209:etiology; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology; D008175:Lung Neoplasms / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis; D008297:Male; D010996:Pleural Effusion / Q000209:etiology*; D011650:Pulmonary Alveoli; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D005169:Factor VIII