Animal experimentation relevant to human marrow transplantation.
Animal experimentation has advanced the understanding of cellular events in the afferent and efferent phases of graft-versus-host disease. New immunosuppressive agents such as FK-506, deoxyspergualin, and interleukin-1 receptor antagonist have shown successful prevention and treatment of graft-versus-host disease in rats and mice. Pretransplant and posttransplant immunosuppressive regimens capable of enhancing engraftment of T-cell-depleted marrow have been defined in murine marrow transplantation. Evidence has begun to emerge indicating that engraftment can be enhanced by T cells that do not cause graft-versus-host disease. Finally, investigations have begun to define approaches for enhancing graft-versus-leukemia effects not only in allogeneic marrow transplantation but also in autologous transplantation.
Martin
P J
PJ
University of Washington, Seattle.
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000502:physiology*; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D007942:Leukemia, Experimental / Q000628:therapy; D008212:Lymphocyte Depletion; D013601:T-Lymphocytes