title: Motor-evoked responses in primary lateral sclerosis.
abstract: Primary lateral sclerosis (PLS) may be distinguished on the basis of clinical and pathological features from amyotrophic lateral sclerosis (ALS). The former is featured by a much longer clinical course, exclusively upper motor neuron findings, losses of precentral pyramidal neurons, and preservation of anterior horn cells. Electrophysiological studies of 7 PLS cases have shown normal peripheral motor conduction, absent or very delayed motor-evoked potentials, the occasional late development of denervation activity in distal muscles, and normal somatosensory-evoked potentials.
authors.affiliation: Department of Clinical Neurological Sciences, University Hospital, London, Ontario, Canada.
authors.forename: W F
authors.initials: WF
authors.lastname: Brown
authors.forename: G C
authors.initials: GC
authors.lastname: Ebers
authors.forename: A J
authors.initials: AJ
authors.lastname: Hudson
authors.forename: C E
authors.initials: CE
authors.lastname: Pringle
authors.forename: J
authors.initials: J
authors.lastname: Veitch
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004576:Electromyography; D005071:Evoked Potentials / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000294:innervation; D009431:Neural Conduction / Q000502:physiology