Serum determinations in toxic isopropanol ingestion.
A toxic dose of isopropyl alcohol was ingested by six male mongrel dogs to evaluate the relationship between acetone production and isopropyl degradation. Maximal serum isopropyl levels were achieved approximately 2 to 3 hours after ingestion of 60 mL of 70% isopropyl alcohol. Acetonemia occurred rapidly in the serum (within 15 minutes of ingestion) and continued to rise after isopropanol levels plateaued. The levels of acetone and isopropanol correlated positively throughout the study model with an r of .54 (P less than .001). It is concluded that there is a positive relationship between acetone production and isopropyl metabolism in the setting of a toxic ingestion of isopropanol. Acetone's persistence as a serum marker may be beneficial in identifying isopropyl hours after a suspected ingestion.
Jerrard
D
D
Division of Emergency Medicine, University of Maryland, Baltimore.
Verdile
V
V
Yealy
D
D
Krenzelok
E
E
Menegazzi
J
J
D000433:1-Propanol / Q000097:blood / Q000378:metabolism / Q000506:poisoning*; D000096:Acetone / Q000097:blood* / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004285:Dogs; D008297:Male; D013997:Time Factors
D015415:Biomarkers; D000096:Acetone; D000433:1-Propanol