Propofol and cholestatic pruritus.
Hepatic cholestatis is frequently associated with pruritus. This pruritus is often intractable and resistant to conventional treatment. We treated three patients with intractable cholestatic pruritus with subhypnotic doses of propofol, a new intravenous anesthetic induction agent. All patients rapidly became itch- and scratch-free for a period of 60-90 min. No sedation occurred; no other side effects were observed.
Borgeat
A
A
Department of Anesthesiology and Digestive Surgery, University Hospital of Geneva, Switzerland.
Wilder-Smith
O
O
Mentha
G
G
Huber
O
O
D000368:Aged; D002779:Cholestasis / Q000150:complications* / Q000209:etiology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications*; D015742:Propofol / Q000627:therapeutic use*; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology
D015742:Propofol