title: [Drug-induced psychiatric disturbance by lidocaine].
abstract: Lidocaine is widely used as an antiarrhythmic agent. One of the side effects of lidocaine is disorientation. Measurement was made of the plasma level of lidocaine in twelve consecutive cases. Lidocaine infusion had been given to these cases for more than twenty-four hours. Measurements were then made of the frequency of psychiatric disturbance. Psychiatric disturbances were recognised in six cases and the plasma levels in four cases among them were more than 5 micrograms.ml-1. The psychiatric disturbances disappeared within three hours after the cessation of lidocaine infusion. When disorientation occurs in a patient who receives lidocaine treatment, drug-induced psychiatric disturbance should be suspected.
authors.affiliation: Department of Anesthesiology, Wakayama Red Cross Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Yoshiyama
authors.forename: T
authors.initials: T
authors.lastname: Tsujimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Sohgawa
authors.forename: T
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects* / Q000097:blood; D008297:Male; D008875:Middle Aged; D009949:Orientation / Q000187:drug effects*
chemical_list: D008012:Lidocaine