title: Anaerobic metabolism as an indicator of aerobic function during exercise in cardiac patients.
abstract: To determine whether patients with heart disease depend more than normal subjects on anaerobic metabolism to perform the same level of exercise, the anaerobic threshold, slope of the increase in carbon dioxide output with respect to oxygen uptake (delta VCO2/delta VO2) and the slope of the increase in oxygen uptake with respect to the increase in work rate (delta VO2/delta WR) both below and above the anaerobic threshold during exercise were evaluated. A total of 106 patients with chronic heart disease and 42 healthy subjects performed a symptom-limited incremental exercise test in a ramp pattern on a cycle ergometer. Peak oxygen uptake was significantly lower in the patients with heart disease than in the normal subjects. The anaerobic threshold, which was 20 +/- 4.6 ml/min per kg in normal subjects, decreased significantly with progressing severity of functional class: 16 +/- 2.4, 14.1 +/- 2.5 and 11.3 +/- 1.5 ml/min per kg, respectively, in patients in class I, class II and class III. The slope of delta VO2/delta WR, which represents the degree of aerobic metabolism, was also decreased both below and above the anaerobic threshold with increasing severity of heart disease. delta VCO2/delta VO2 below the anaerobic threshold was approximately 0.9 (p = NS between normal subjects and patients). However, delta VCO2/delta VO2 above the anaerobic threshold became steeper with increasing severity of heart disease: 1.37 +/- 0.17 in normal subjects versus 1.55 +/- 0.24, 1.67 +/- 0.3 and 1.8 +/- 0.35 respectively, in patients in functional class I, class II and class III.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Koike
authors.forename: M
authors.initials: M
authors.lastname: Hiroe
authors.forename: H
authors.initials: H
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Yajima
authors.forename: A
authors.initials: A
authors.lastname: Nogami
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Takamoto
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D000332:Aerobiosis / Q000502:physiology; D015308:Anaerobic Threshold / Q000502:physiology*; D000693:Anaerobiosis / Q000502:physiology; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000378:metabolism*; D005260:Female; D006331:Heart Diseases / Q000378:metabolism / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D011659:Pulmonary Gas Exchange
chemical_list: D002245:Carbon Dioxide