Analysis of determinants of ventricular fibrillation induced by reperfusion: dissociation between electrical instability and myocardial damage.
To assess the underlying mechanisms of ventricular fibrillation induced by myocardial reperfusion after cardioplegic arrest, 62 patients undergoing an open heart operation were divided into two groups based on the absence (group 1, n = 37) or the development (group 2, n = 25) of reperfusion-induced ventricular fibrillation. There was no close relationship between the incidence of reperfusion-induced ventricular fibrillation and aortic clamp time. On reperfusion, the time to onset of cardiac activity was similar in groups 1 (2.4 +/- 1.8 minutes) and 2 (1.9 +/- 1.1 minutes). At that time, there was no significant difference in values of arterial oxygen and bicarbonate contents, pH, or base excess between the two groups, but myocardial temperature was significantly higher in group 2 (25.6 degrees +/- 3.4 degrees versus 27.6 degrees +/- 2.4 degrees C; p less than 0.05). In addition, serum levels of sodium (123.9 +/- 4.2 versus 126.1 +/- 3.7 mmol/L; p less than 0.05) and calcium (0.80 +/- 0.07 versus 0.84 +/- 0.05 mmol/L; p less than 0.05) were significantly higher and serum potassium levels (3.98 +/- 0.58 versus 3.55 +/- 0.61 mmol/L; p less than 0.02) and the serum potassium to calcium ratio (4.94 +/- 0.90 versus 4.29 +/- 0.72; p less than 0.01) significantly lower in group 2. Postoperative serum levels of the myocardial-specific isoenzyme of creatine kinase and myoglobin were similar in both groups. By multivariate analysis, shorter ischemic time, higher myocardial temperature, higher serum sodium concentration, and lower serum potassium to calcium ratio were found to influence induction of reperfusion-induced ventricular fibrillation.(ABSTRACT TRUNCATED AT 250 WORDS)
Kinoshita
K
K
Division of Cardiovascular Surgery, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
Mitani
A
A
Tsuruhara
Y
Y
Kanegae
Y
Y
Tokunaga
K
K
D001831:Body Temperature; D002245:Carbon Dioxide / Q000097:blood; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography; D004573:Electrolytes / Q000097:blood; D006801:Humans; D015425:Myocardial Reperfusion / Q000009:adverse effects*; D010100:Oxygen / Q000097:blood; D014693:Ventricular Fibrillation / Q000097:blood / Q000209:etiology* / Q000503:physiopathology
D004573:Electrolytes; D002245:Carbon Dioxide; D003402:Creatine Kinase; D010100:Oxygen