title: Childhood bacterial meningitis in Al-Baha province, Saudi Arabia.
abstract: A retrospective review of 71 paediatric patients admitted with bacterial meningitis to the King Fahad Hospital at Al-Baha, Saudi Arabia, during an 8-year period revealed a preponderance of males (67.6%) and young subjects with 88.7% being below 24 months of age. The commonest cerebrospinal fluid pathogens in the series were Haemophilus influenzae type B (HIB), Streptococcus pneumoniae and Group B-beta haemolytic streptococcus, which were responsible for 47.3, 34.5 and 9.1% of cases respectively. Neisseria meningitidis which is a major cause of meningitis in most other reports was uncommon in the present series, and was isolated from only two patients. All the children with Group B-beta haemolytic streptococcal meningitis were below 3 months of age while 96.2% of the children with HIB meningitis were younger than 2 years. Mortality was highest (40%) among the infants with Group B-beta haemolytic streptococcal meningitis. Six (23.1%) of the HIB isolated were resistant to ampicillin and two (7.7%) were resistant to both ampicillin and chloramphenicol. There is a need for greater emphasis on prevention through the use of available vaccines including the newly introduced conjugate vaccines against HIB which are capable of eliciting immune responses in infants as young as 2 months.
authors.affiliation: Department of Paediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: N A
authors.initials: NA
authors.lastname: al-Jurayyan
authors.forename: A S
authors.initials: AS
authors.lastname: al Mazyad
authors.forename: M N
authors.initials: MN
authors.lastname: al-Nasser
authors.forename: Y A
authors.initials: YA
authors.lastname: al-Eissa
authors.forename: A M
authors.initials: AM
authors.lastname: Abo-Bakr
authors.forename: A G
authors.initials: AG
authors.lastname: Boohene
authors.forename: J B
authors.initials: JB
authors.lastname: Familusi
mesh_terms: D016470:Bacteremia / Q000382:microbiology; D002555:Cerebrospinal Fluid / Q000166:cytology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000382:microbiology; D008583:Meningitis, Haemophilus / Q000453:epidemiology; D008585:Meningitis, Meningococcal / Q000453:epidemiology; D008586:Meningitis, Pneumococcal / Q000453:epidemiology; D012189:Retrospective Studies; D012529:Saudi Arabia / Q000453:epidemiology; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology