CD4 and CD8 may adopt a similar mode of binding to their MHC ligands.
A theoretical scheme is proposed by which the type-specific cell surface receptors of T-lymphocytes, CD8 and CD4, bind class I and II MHC proteins in a similar manner. The scheme has equivalent residues in the C'/C'' loop-C'' strand-C''/D loop region in domain 1 of CD4 and CD8 alpha binding to equivalent residues in the C and D beta-strands and C/D loops in HLA-DR beta 2 (class II) and HLA-A2 alpha 3 (class I) respectively through a series of electrostatic, hydrogen and hydrophobic bonds.
Brinkworth
R I
RI
Centre for Drug Design and Development, University of Queensland, Brisbane, Australia.
D000595:Amino Acid Sequence; D001665:Binding Sites; D015704:CD4 Antigens / Q000378:metabolism*; D016827:CD8 Antigens / Q000378:metabolism*; D006680:HLA Antigens / Q000378:metabolism*; D015234:HLA-A Antigens / Q000378:metabolism; D006684:HLA-DR Antigens / Q000378:metabolism; D008024:Ligands; D008962:Models, Theoretical; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid
D015704:CD4 Antigens; D016827:CD8 Antigens; D006680:HLA Antigens; D015234:HLA-A Antigens; D006684:HLA-DR Antigens; D008024:Ligands