Hepatotoxicity associated with cocaine abuse.
The mechanisms evaluated in animals as being responsible for cocaine associated hepatotoxicity are presented. The importance of the P-450 enzyme system in cocaine associated hepatotoxicity is emphasized. Moreover, the putative critical role of free radicals in such injury is discussed. Finally, the growing literature on clinical cases of cocaine hepatotoxicity is reviewed.
Van Thiel
D H
DH
Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15213.
Perper
J A
JA
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D003042:Cocaine / Q000009:adverse effects* / Q000493:pharmacokinetics; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D006801:Humans; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications* / Q000201:enzymology / Q000534:rehabilitation
D003577:Cytochrome P-450 Enzyme System; D003042:Cocaine