title: Closed circular DNA as a probe for protein-induced structural changes.
abstract: Biological systems are replete with examples of DNA formed into a closed loop structure, either alone or in close association with proteins. Such closed circular DNA molecules are subject to a topological constraint that modifies, often in a major way, the structure and reactivity of the DNA. The topological constraint also permits closed circular DNAs to be used as analytical tools to learn about the structure of DNA-protein complexes.
authors.affiliation: Department of Mathematics, University of California, Los Angeles 90024.
authors.forename: J H
authors.initials: JH
authors.lastname: White
authors.forename: R M
authors.initials: RM
authors.lastname: Gallo
authors.forename: W R
authors.initials: WR
authors.lastname: Bauer
mesh_terms: D015342:DNA Probes; D004270:DNA, Circular / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D013329:Structure-Activity Relationship
chemical_list: D015342:DNA Probes; D004270:DNA, Circular; D004268:DNA-Binding Proteins; D012321:DNA-Directed RNA Polymerases