Comparative absorption of atropine from a metered-dose inhaler and an intramuscular injection.
The inhalation of atropine sulfate from a pressurized metered-dose inhaler was investigated in a nonrandomized four-period rising-dose study. Eight healthy, nonsmoking subjects received 1.7, 3.4, and 5.2 mg of atropine sulfate by inhalation and 1.67 mg of atropine free base (equivalent to 2 mg of atropine sulfate) by intramuscular (i.m.) injection. Serum atropine sulfate concentrations were measured over a 24-h period by gas chromatography/mass spectrometry. Mean serum concentrations increased nonproportionally as the inhaled dose increased. Mean peak concentrations were 4.9, 6.1, and 7.9 ng/ml for the inhaled doses and 8.4 ng/ml for the i.m. dose. Typical anticholinergic effects were seen after all doses.
Kehe
C R
CR
3M Pharmaceuticals, St. Paul, Minnesota.
Lasseter
K C
KC
Miller
N C
NC
Wick
K A
KA
Shamblen
E C
EC
Ekholm
B P
BP
Sandahl
J H
JH
Chang
S F
SF
Goldlust
M B
MB
Kvam
D C
DC
D000042:Absorption; D000280:Administration, Inhalation; D000328:Adult; D001285:Atropine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008401:Gas Chromatography-Mass Spectrometry; D006207:Half-Life; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009330:Nebulizers and Vaporizers
D001285:Atropine