Glial fibrillary acidic protein stimulates proliferation and immunoglobulin synthesis of lymphocytes from Alzheimer's disease patients.
The level of anti-GFAP (glial fibrillary acidic protein) IgG antibody titer was assayed in sera of patients with Alzheimer's disease, multi-infarct dementia, and the age-matched control subjects. Significantly higher level of anti-CFAP titer was found in sera of Alzheimer's disease patients. The in vitro lymphocyte response was studied by stimulation with GFAP and interleukin 2 (IL-2). The lymphocytes of Alzheimer's disease patients showed higher proliferative response than those of the control by GFAP and IL-2 stimulation. The IgG secretion by lymphocytes from Alzheimer's disease patients was also stimulated by GFAP as well as by GFAP plus IL-2. The results demonstrate that the lymphocytes of Alzheimer's disease patients are more responsive to GFAP than those of the control subjects.
Nakamura
K
K
Department of Neuropsychiatry, Osaka University Medical School, Japan.
Takeda
M
M
Tanaka
T
T
Tanaka
J
J
Kato
Y
Y
Nishinuma
K
K
Nishimura
T
T
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000276:immunology; D002455:Cell Division; D002478:Cells, Cultured; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D008875:Middle Aged
D005904:Glial Fibrillary Acidic Protein; D007074:Immunoglobulin G