CGS 5649 B, a new compound, reverses age-related cognitive dysfunctions in rats.
CGS 5649 B improves the learning performance of aged rats in a one-way active-avoidance situation. If, under reversed conditions, treated aged rats are also tested for passive avoidance, they show "place learning," which our findings have demonstrated to be typical of young rats. The effects of the substance are not confined to these experimental models nor are they species specific: it also facilitates passive avoidance in mice and social learning in rats. The compound is effective if administered before or immediately after the learning trial.
Mondadori
C
C
Pharmaceutical Research Department, Ciba-Geigy Limited, Basel, Switzerland.
Buerki
H
H
Borkowski
J
J
Radeke
E
E
Ducret
T
T
Glatt
A
A
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004877:Ergoloid Mesylates / Q000494:pharmacology; D005650:Fumarates / Q000494:pharmacology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010889:Piracetam / Q000494:pharmacology; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D012193:Reversal Learning / Q000187:drug effects; D012919:Social Behavior
D005650:Fumarates; D004877:Ergoloid Mesylates; C032005:fumaric acid; D010889:Piracetam