Trisomy 4 in acute nonlymphocytic leukemia. Report of two cases and review of the literature.
Two patients with M2 subtype of acute nonlymphocytic leukemia (ANLL) and trisomy 4 as a primary karyotype change are described. The abnormality was observed in 100% of bone marrow (BM) metaphases in both cases. It appeared alone in one case and was associated with trisomy 13 in 94% of metaphases in the other. These are the second and third cases of ANLL with trisomy 4 documented in Italy. Neither patient appears to have incurred any environmental or therapeutic insult.
Donti
E
E
First Department of Internal Medicine, University of Perugia, Italy.
Maccari
A
A
Tabilio
A
A
Ardisia
C
C
Campanari
N
N
Donti
G V
GV
D000368:Aged; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014407:Tumor Cells, Cultured