title: Development and long-term fate of a cellular lining in fibrous polyurethane vascular prostheses implanted in the dog carotid and femoral artery. A scanning and light microscopical study up to 53 months after implantation.
abstract: The development and long-term fate of the inner cellular lining in 72 small caliber (3 mm inner diameter) fibrous polyurethane vascular prostheses explanted from dog carotid and/or femoral arteries at times ranging from 1.5 weeks up to 53 months after implantation were studied by scanning electron and light microscopy. A continuous cellular ingrowth from the vascular stumps into the 3 cm long prostheses was observed, which eventually resulted in a complete cellular lining 6 months after implantation. No other ways of endothelialization were noted. In fully endothelialized prostheses, the cellular ingrowth extended approximately 8 mm into the prostheses and consisted of several layers of fibroblasts and smooth muscle cells, covered by a very thin endothelioid cell layer. The newly developed lining was firmly anchored onto the inner prosthetic surface by means of cellular protrusions extended into the fibrous texture of the prosthetic wall. It was concluded that under experimental conditions in the dog complete endothelialization can be obtained in fibrous polyurethane vascular prostheses and that the lining remained thin and stable throughout the observation period of 53 months after implantation.
authors.affiliation: Laboratory Cellbiology and Histology, University Nijmegen, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Hess
authors.forename: C
authors.initials: C
authors.lastname: Jerusalem
authors.forename: S
authors.initials: S
authors.lastname: Steeghs
authors.forename: O
authors.initials: O
authors.lastname: Reijnders
authors.forename: B
authors.initials: B
authors.lastname: Braun
authors.forename: P
authors.initials: P
authors.lastname: Grande
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D001807:Blood Vessel Prosthesis / Q000706:statistics & numerical data; D002339:Carotid Arteries / Q000601:surgery* / Q000648:ultrastructure; D004285:Dogs; D004730:Endothelium, Vascular / Q000648:ultrastructure*; D005260:Female; D005263:Femoral Artery / Q000601:surgery* / Q000648:ultrastructure; D005500:Follow-Up Studies; D008297:Male; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes; D011474:Prosthesis Design; D013997:Time Factors
chemical_list: D011140:Polyurethanes