[An animal model of posttraumatic multiple system organ failure (MSOF)].
Hemorrhagic shock, sepsis, excessive systemic inflammatory reactions, and failure of intestinal mucosal barrier function are known to be major predisposing factors in the development of MSOF in patients after severe trauma or burns. We investigated the possibility of complicating clinically simulating MSOF in animals. Our results showed that, with compounded traumatic factors, including damages to the bowel, and proper circulatory and respiratory support, an animal model which simulated the pathophysiology and histopathology of MSOF could be reproduced to offer opportunity for the study of mechanisms and therapy. Markers of MSOF were also described for reference.
Hu
S
S
Trauma Center, Postgraduate Medical College, PLA 304th Hospital, Beijing.
D000818:Animals; D016470:Bacteremia / Q000150:complications; D004195:Disease Models, Animal; D004285:Dogs; D007421:Intestine, Small / Q000098:blood supply; D007511:Ischemia / Q000150:complications; D008297:Male; D009102:Multiple Organ Failure / Q000209:etiology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000150:complications; D014947:Wounds and Injuries / Q000150:complications*