title: The antihypertensive effect of dietary supplementation with a 6-desaturated essential fatty acid concentrate as compared with sunflower seed oil.
abstract: There is increasing evidence that the type of fat in the diet may play a role in the control of blood pressure and development of hypertension. The purpose of the present study was to investigate the effect of a concentrated preparation of the 6-desaturated essential fatty acids gamma-linolenic acid (C18:3n-6), eicosapentaenoic acid (C20:5n-3) and docosahexaenoic acid (C22:6n-3) on individuals with raised BP. Eighteen volunteers from our College staff with elevated BP on several occasions but otherwise healthy, were divided into two groups following a two-week baseline period. One group received 4g sunflower seed oil daily and the other 4g of an oil preparation rich in C18:3n-6, C20:5n-3 and C22:6n-3 for six weeks. Major measurements included BP and fatty acids in phospholipids and cholesteryl esters. Dietary intakes and urinary fluid and electrolyte excretion were also monitored during baseline and intervention periods. The subjects' office diastolic BP showed a significantly greater effect of the concentrate over the sunflower seed oil, both overall (P = 0.03) and in interaction with time (P = 0.012). Fatty acids in plasma cholesteryl esters underwent mild alterations following the administration of the concentrate. There were no important changes in nutrient intakes or in sodium, potassium and fluid excretion during the trial period.
authors.affiliation: Department of Nutrition and Dietetics, King's College London, University of London, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Deferne
authors.forename: A R
authors.initials: AR
authors.lastname: Leeds
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004231:Diuresis; D005227:Fatty Acids / Q000097:blood; D005228:Fatty Acids, Essential / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006368:Helianthus; D006801:Humans; D008094:Lithium / Q000097:blood; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D000959:Antihypertensive Agents; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D010938:Plant Oils; D008094:Lithium