title: [Synaptophysin in the nervous system and endocrine cells].
abstract: Synaptophysin is a major integral membrane glycoprotein of neuronal synaptic vesicles that is present in virtually all synapses and shows a high degree of evolutionary conservation in mammalian species. It has also been detected in numerous endocrine cell types where it is localized in the membrane of small synaptic-like vesicles which are thought to constitute a previously unknown secretory pathway. Antibodies directed against synaptophysin are a valuable tool for the immunohistochemical quantitation of synapses. Moreover, synaptophysin is a most reliable and specific marker molecule for normal and neoplastic neuroendocrine cells. In the nervous system, synaptophysin-positive tumors comprise ganglioneuromas, ganglioneuroblastomas, neuroblastomas, paragangliomas and primitive neuroectodermal tumors.
authors.affiliation: Abteilung Anatomie 1 Medizinischen Hochschule Hannover.
authors.forename: P
authors.initials: P
authors.lastname: Redecker
authors.forename: D
authors.initials: D
authors.lastname: Grube
mesh_terms: D000818:Animals; D004702:Endocrine Glands / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009420:Nervous System / Q000378:metabolism*; D016708:Synaptophysin / Q000378:metabolism*
chemical_list: D016708:Synaptophysin
vernacular_title: Synaptophysin im Nervensystem und in endokrinen Zellen.