Dual-action penems and carbapenems.
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.
Corraz
A J
AJ
Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
Dax
S L
SL
Dunlap
N K
NK
Georgopapadakou
N H
NH
Keith
D D
DD
Pruess
D L
DL
Rossman
P L
PL
Then
R
R
Unowsky
J
J
Wei
C C
CC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D015780:Carbapenems