Local control of prostate cancer by intraarterial infusion chemotherapy facilitated by the use of angiotensin II.
Intraarterial infusion chemotherapy with angiotensin II was carried out in 8 prostate cancer patients whose ages ranged from 61 to 77 years. They had stage C or D tumor progression and complained of difficult urination, bone pain or lymphedema caused by intrapelvic tumor infiltration. Endocrine therapy had been done before the infusion therapy but the clinical status showed little change with a persistence of local symptoms. Cis-platinum and doxorubicin were infused with an indwelling catheter into both internal iliac arteries. After the completion of 1-5 courses, 6 of 8 patients responded remarkably in local symptoms. It is thought that intraarterial infusion chemotherapy can be used safely and effectively in elderly patients.
Mutoh
S
S
Department of Urology, Kumamoto University Medical School, Japan.
Aikou
I
I
Soejima
K
K
Ueda
S
S
Fukushima
S
S
Kishimoto
S
S
Takagi
Y
Y
D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D000804:Angiotensin II / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002408:Catheters, Indwelling; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007083:Iliac Artery; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D000804:Angiotensin II; D004317:Doxorubicin; D002945:Cisplatin