G1 events and the regulation of genes for S-phase enzymes.
The genes for S-phase enzymes are expressed at low levels in quiescent mammalian cells but at high levels during DNA replication. Regulation occurs at multiple levels by mechanisms that are different for each gene. Current research is focused on identifying the control elements and trans-acting factors for each gene and establishing relationships between these regulatory mechanisms and the G1 signal transduction pathway.
Johnson
L F
LF
Ohio State University, Columbus.
D000818:Animals; D002453:Cell Cycle / Q000235:genetics* / Q000502:physiology; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics; D013940:Thymidylate Synthase / Q000235:genetics
D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase