title: Embryonic stem cells and homologous recombination.
abstract: Mice with defined genetic defects can now be generated using gene targeting technology based on the successful generation of mouse embryonic stem cells with the potential for germ line transmission, and the development of methods for detection of homologous recombination.
authors.affiliation: R.W. Johnson Pharmaceutical Research Institute, Toronto, Canada.
authors.forename: W P
authors.initials: WP
authors.lastname: Fung-Leung
authors.forename: T W
authors.initials: TW
authors.lastname: Mak
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D004622:Embryo, Mammalian / Q000276:immunology; D005802:Genes, MHC Class II / Q000276:immunology; D006410:Hematopoiesis / Q000276:immunology; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology; D008822:Mice, Transgenic / Q000276:immunology; D011995:Recombination, Genetic / Q000276:immunology*; D013234:Stem Cells / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology