12q13 abnormality in rhabdomyosarcoma. A nonrandom occurrence?
We describe two cases of rhabdomyosarcoma with a translocation involving 12q13 as the primary cytogenetic abnormality. Literature review of 35 cases has identified 3 other cases with this abnormality, and we speculate that this may be another nonrandom rearrangement in rhabdomyosarcoma.
Roberts
P
P
Regional Cytogenetics Unit, St. James's University Hospital, Leeds, United Kingdom.
Browne
C F
CF
Lewis
I J
IJ
Bailey
C C
CC
Spicer
R D
RD
Williams
J
J
Batcup
G
G
D000293:Adolescent; D002648:Child; D002881:Chromosomes, Human, Pair 12; D005260:Female; D006801:Humans; D008297:Male; D012208:Rhabdomyosarcoma / Q000235:genetics* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000235:genetics* / Q000628:therapy; D013848:Thigh; D014178:Translocation, Genetic / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000628:therapy