Antithrombotic activity of verapamil.
The antithrombotic activity of verapamil (Ver) was assessed in an arterial thrombosis model and an ex vivo thrombosis model. Ver 2 and 4 mg.kg-1 ip markedly prolonged the time of thrombotic occlusion in rat carotid artery induced by electric stimulation. The weight of thrombus formed ex vivo was reduced by Ver 0.2 mg.kg-1 iv. However, Ver showed no effects on blood viscosity.
Liao
C L
CL
Thrombosis Research Centre, Shenzhen Institute of Geriatrics, China.
Zou
Q J
QJ
Li
J M
JM
Cui
H
H
Yuan
N R
NR
D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D005260:Female; D008297:Male; D011817:Rabbits; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy* / Q000517:prevention & control; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use*
D014700:Verapamil