title: Immunological abnormalities in haemophiliacs.
abstract: 10 years ago, it became apparent that haemophiliacs were developing diseases which were indicative of underlying immunodeficiency. The results of investigation confirmed that many had abnormal immune systems, particularly with regard to cell-mediated immunity. These abnormalities were thought to be a consequence of the use of clotting factor concentrates, and indeed the discovery of HIV and its mode of transmission, confirmed these suspicions. However, it subsequently became clear that HIV infection did not explain all the abnormalities observed. Many in vivo studies have shown that the immune systems of HIV-negative haemophiliacs are not entirely normal, and in vitro studies have shown that clotting factor concentrates per se have a modulating effect on immune function. We have reviewed particularly the abnormalities seen in HIV-negative haemophiliacs and their possible causes, as well as the specific features of HIV infection in haemophiliacs.
authors.affiliation: Department of Haematology, Royal Infirmary of Edinburgh, UK.
authors.forename: H G
authors.initials: HG
authors.lastname: Watson
authors.forename: C A
authors.initials: CA
authors.lastname: Ludlam
mesh_terms: D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D015658:HIV Infections / Q000209:etiology / Q000635:transmission; D006679:HIV Seropositivity / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications / Q000276:immunology* / Q000401:mortality; D006801:Humans; D008107:Liver Diseases / Q000209:etiology; D065227:Transfusion Reaction; D014779:Virus Replication / Q000276:immunology
chemical_list: D001779:Blood Coagulation Factors