title: Effects of m-nisoldipine and nisoldipine on electric activity of human atrial tissue.
abstract: Using intracellular microelectrode technique and microcomputer analyzing system, the effects of m-nisoldipine (m-Nis) and nisoldipine (Nis) on spontaneous electric activity of human atrial tissue were studied. APA and Vmax were remarkably decreased by m-Nis (0.25 and 1.25 mumol.L-1) and Nis (0.25 mumol.L-1). RPF was also greatly decreased as a result of inhibition in VDD. The inhibitory effects of m-Nis on transmembrane potentials were less than those of Nis at equal concentration (0.25 mumol.L-1). Neither MDP nor APD90 was affected by m-Nis and Nis.
authors.affiliation: Department of Physiology, Institute of Basic Medicine, Hebei Medical College, Shijiazhuang, China.
authors.forename: X P
authors.initials: XP
authors.lastname: Yang
authors.forename: R H
authors.initials: RH
authors.lastname: An
authors.forename: R R
authors.initials: RR
authors.lastname: He
authors.forename: Y K
authors.initials: YK
authors.lastname: Xie
authors.forename: S X
authors.initials: SX
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Liu
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D016275:Atrial Function; D002648:Child; D002675:Child, Preschool; D006801:Humans; D066298:In Vitro Techniques; D007536:Isomerism; D008839:Microelectrodes; D015737:Nisoldipine / Q000494:pharmacology*
chemical_list: D015737:Nisoldipine