title: Hepatotoxicity associated with cocaine abuse.
abstract: The mechanisms evaluated in animals as being responsible for cocaine associated hepatotoxicity are presented. The importance of the P-450 enzyme system in cocaine associated hepatotoxicity is emphasized. Moreover, the putative critical role of free radicals in such injury is discussed. Finally, the growing literature on clinical cases of cocaine hepatotoxicity is reviewed.
authors.affiliation: Department of Surgery, University of Pittsburgh School of Medicine, Pennsylvania 15213.
authors.forename: D H
authors.initials: DH
authors.lastname: Van Thiel
authors.forename: J A
authors.initials: JA
authors.lastname: Perper
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology*; D003042:Cocaine / Q000009:adverse effects* / Q000493:pharmacokinetics; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D006801:Humans; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications* / Q000201:enzymology / Q000534:rehabilitation
chemical_list: D003577:Cytochrome P-450 Enzyme System; D003042:Cocaine