title: Lupus anticoagulant: correlation with magnetic resonance imaging of brain lesions.
abstract: Brain magnetic resonance imaging (MRI) was performed in 21 patients with systemic lupus erythematosus (SLE) with and without lupus anticoagulant (LAC), one lupus-like patient and 5 patients with primary antiphospholipid antibody syndrome. Thirteen patients had white matter focal brain lesions on MRI, 10 of whom had LAC (p = 0.03). We found no correlation between these lesions and neurologic manifestations, nor any clinical or serologic indices of activity of SLE. Our MRI lesions were similar to those described in multiple sclerosis and may indicate a similar pathologic process.
authors.affiliation: Beilinson Medical Center, Petah Tiqva, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Molad
authors.forename: Y
authors.initials: Y
authors.lastname: Sidi
authors.forename: M
authors.initials: M
authors.lastname: Gornish
authors.forename: M
authors.initials: M
authors.lastname: Lerner
authors.forename: J
authors.initials: J
authors.lastname: Pinkhas
authors.forename: A
authors.initials: A
authors.lastname: Weinberger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis*; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000378:metabolism*; D008177:Lupus Vulgaris / Q000175:diagnosis / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: D016682:Lupus Coagulation Inhibitor