title: [Functional activity of leukocytes and enzyme indicators in acute intestinal infections].
abstract: To assess functional activity of leukocytes, lipid peroxidation and enzymes indicating the severity of organ lesion in food poisoning and acute dysentery, the investigators employed the techniques of luminol- and biacridine-activated chemiluminescence of pure granulocyte population and whole blood, plasma chemiluminescence, assays of AAT, AsAT, AP, LDG. A relationship was established between chemiluminescence of leukocytes and whole blood, between leukocytic functional activity and the disease duration and severity. Indomethacin treatment of the patients reduced intoxication, did not affect leukocytic function, diminished plasma chemiluminescence. Functional activity of leukocytes and the enzymes levels were prognostically significant. Low response of leukocytes to the stimulus, i.e. a small rise of functional activity, served an unfavourable prognostic sign. A role of active oxygen forms produced by leukocytes is suggested in pathogenesis of alimentary toxo-infection.
authors.forename: P Iu
authors.initials: PIu
authors.lastname: Popov
authors.forename: I M
authors.initials: IM
authors.lastname: Roslyĭ
authors.forename: V A
authors.initials: VA
authors.lastname: Malov
authors.forename: S G
authors.initials: SG
authors.lastname: Pak
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004796:Clinical Enzyme Tests; D004403:Dysentery / Q000097:blood* / Q000175:diagnosis; D005517:Foodborne Diseases / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008875:Middle Aged
chemical_list: D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000135:Acid Phosphatase; D007213:Indomethacin
vernacular_title: Funktsional'naia aktivnost' leĭkotsitov i nekotorye énzimologicheskie pokazateli pri ostrykh kishechnykh infektsiiakh.