[Good results of cyclophosphamide in steroid toxicity in the treatment of nephrotic syndrome caused by minimal-lesion glomerulopathy in childhood].
The effect of cyclophosphamide therapy was evaluated in the treatment of children with nephrotic syndrome due to minimal lesions. Most of the children, 37 out of 43, presented with frequent relapsing nephrotic syndrome. Cyclophosphamide was given in a dose of 3 mg/kg body weight/day for a period of 8 weeks. Two patients received two courses, one patient received three courses. Only one patient, who was steroid-resistant, did not respond to cyclophosphamide therapy (therapy was, however, stopped after 3 weeks because of haemorrhagic cystitis). 57% of the patients were still in remission after 18 months (n = 37) and 50% after 30 months (n = 34). A haemorrhagic cystitis developed in 3 patients and leucopenia in 2 patients. From this study, which confirms data reported in literature, it can be concluded that cyclophosphamide has a beneficial effect in children with minimal lesion nephrotic syndrome and steroid toxicity.
de Moor
R
R
Academisch Ziekenhuis St. Radboud, afd. Kindernefrologie, Nijmegen.
de Jong
M
M
Monnens
L
L
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use*; D003556:Cystitis / Q000139:chemically induced; D004351:Drug Resistance; D004361:Drug Tolerance; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007970:Leukopenia / Q000139:chemically induced; D009402:Nephrosis, Lipoid / Q000150:complications*; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000209:etiology; D012074:Remission Induction; D012189:Retrospective Studies
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide
Goede resultaten van cyclofosfamide bij steroïdtoxiciteit in de behandeling van het nefrotisch syndroom door 'minimal lesion'-glomerulopathie op kinderleeftijd.