title: Copper-metallothionein induction in the liver of LEC rats.
abstract: Recently, copper (Cu) was found to be unusually accumulated, suggesting the induction of metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop spontaneous jaundice with hereditary hepatitis. Thus, the direct relationship between the unusual Cu accumulation and the induction of Cu-MT was investigated by giving LEC rats Cu-overloaded or Cu-deficient diets. Results based on the determinations of Cu and MT levels in several organs, as well as the gel-filtration profiles of the cytosols of liver homogenates, showed that dietary Cu induced Cu-MT and development of hepatic injury associated with jaundice.
authors.affiliation: Department of Analytical Chemistry, Kyoto Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: H
authors.initials: H
authors.lastname: Kamada
authors.forename: A
authors.initials: A
authors.lastname: Fukudome
authors.forename: M
authors.initials: M
authors.lastname: Kito
authors.forename: S
authors.initials: S
authors.lastname: Takeshima
authors.forename: M
authors.initials: M
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Otaki
authors.forename: K
authors.initials: K
authors.lastname: Nakajima
authors.forename: K
authors.initials: K
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Hagino
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D006520:Hepatitis, Animal / Q000235:genetics*; D007565:Jaundice / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008668:Metallothionein / Q000096:biosynthesis*; D051381:Rats; D011922:Rats, Mutant Strains
chemical_list: D003300:Copper; D008668:Metallothionein