title: Nitrous oxide administration using commonly available oxygen therapy devices.
abstract: Administration of nitrous oxide is useful for providing sedation and analgesia. The therapeutic range for nitrous oxide is 20-30%. Several oxygen treatment devices have been used for administering nitrous oxide, but little is known about the concentrations of nitrous oxide and oxygen delivered to the trachea. We have studied this, using an analogue lung model, with several oxygen therapy devices. With a 1:1 nitrous oxide-oxygen mixture in the primary flow for all systems, end-expired nitrous oxide concentrations varied between 6.5% and 34.3%. Therapeutic concentrations were produced using the Hudson (nominal oxygen concentration 60%) fixed-performance mask, the variable performance Hudson mask at 4 litre min-1, the MC masks at 4 and 6 litre min-1 and the nasal prongs at 6 and 8 litre min-1. Simultaneous end-expired oxygen concentrations for all devices tested were within a safe range.
authors.affiliation: Magill Department of Anaesthetics, Westminster Hospital, London.
authors.forename: P
authors.initials: P
authors.lastname: Joshi
authors.forename: R
authors.initials: R
authors.lastname: Ooi
authors.forename: N
authors.initials: N
authors.lastname: Soni
mesh_terms: D000698:Analgesia; D000769:Anesthesia, Inhalation / Q000295:instrumentation; D006801:Humans; D006993:Hypnotics and Sedatives; D008168:Lung / Q000502:physiology; D008397:Masks; D008954:Models, Biological; D009609:Nitrous Oxide / Q000008:administration & dosage*; D010100:Oxygen / Q000008:administration & dosage*; D010102:Oxygen Inhalation Therapy / Q000295:instrumentation*
chemical_list: D006993:Hypnotics and Sedatives; D009609:Nitrous Oxide; D010100:Oxygen