Mutations in the precursor region of a Bacillus subtilis sporulation sigma factor.
Transcription from some sporulation-specific promoters of Bacillus subtilis is dependent on synthesis of pro-sigma E and its conversion to sigma E by proteolysis. Certain mutations in the precursor region of sigE, the gene encoding pro-sigma E, apparently allow the mutant sigE products to be active as sigma factors without being proteolysed in the normal way.
Rong
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Department of Molecular Biology and Microbiology, Tufts University Health Sciences Campus, Boston, Massachusetts 02111.
Sonenshein
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D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D009024:Morphogenesis; D016296:Mutagenesis; D011401:Promoter Regions, Genetic / Q000235:genetics; D011498:Protein Precursors / Q000096:biosynthesis / Q000235:genetics*; D011499:Protein Processing, Post-Translational; D012689:Sequence Homology, Nucleic Acid; D012808:Sigma Factor / Q000096:biosynthesis / Q000235:genetics*; D013171:Spores, Bacterial / Q000378:metabolism; D014157:Transcription Factors
D001426:Bacterial Proteins; D011498:Protein Precursors; D012808:Sigma Factor; D014157:Transcription Factors; C092468:spoIIR protein, Bacillus subtilis; C030069:spore-specific proteins, Bacillus; C063202:sporulation-specific sigma factors