Replication of action of cholecystokinin tetrapeptide in panic disorder: clinical and behavioral findings.
Eleven patients with panic disorder were challenged with cholecystokinin tetrapeptide (CCK-4) on two occasions. The effects of CCK-4 were consistent except symptom onset was more rapid with the second injection. Demonstrating that the effects of CCK-4 are reproducible in panic patients opens the doors for studies of the effects of drug treatment on CCK-4-induced panic.
Bradwejn
J
J
Division of Psychopharmacology, St. Mary's Hospital Center, Montreal, PQ, Canada.
Koszycki
D
D
Payeur
R
R
Bourin
M
M
Borthwick
H
H
D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000139:chemically induced* / Q000523:psychology; D010555:Personality Inventory; D010919:Placebos; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013758:Tetragastrin / Q000008:administration & dosage / Q000494:pharmacology
D010919:Placebos; D013758:Tetragastrin