Eicosanoids production in endometriosis.
In order to investigate the production of eicosanoids in human endometrium, myometrium, leiomyoma, adenomyosis, normal ovary, non-endometrial cyst and endometrial cyst, slices of each tissue were incubated. 6-Keto-prostaglandin (PG) F1 alpha, thromboxane (TX) B2, PGF2 alpha and PGE2 concentrations in the incubation medium were measured by direct RIA. 6-Keto-PGF1 alpha production of adenomyosis was significantly higher than that of endometrium, myometrium and leiomyoma, especially in the menstrual phase. The production of eicosanoids in endometrial cyst was significantly higher than that of non-endometrial cyst and normal ovary. These results suggest that endometriosis is associated with increased eicosanoid production in vivo.
Koike
H
H
Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
Egawa
H
H
Ohtsuka
T
T
Yamaguchi
M
M
Ikenoue
T
T
Mori
N
N
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000328:Adult; D003560:Cysts / Q000378:metabolism; D015237:Dinoprost / Q000096:biosynthesis; D015232:Dinoprostone / Q000096:biosynthesis; D015777:Eicosanoids / Q000096:biosynthesis*; D004715:Endometriosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D013929:Thromboxane B2 / Q000096:biosynthesis; D014594:Uterine Neoplasms / Q000378:metabolism
D015777:Eicosanoids; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D015232:Dinoprostone