title: Intra-arterial 4-hydroxyanisole chemotherapy for locally recurrent malignant melanoma: a re-appraisal.
abstract: Ten female patients with recurrent cutaneous malignant melanoma (MM) confined to the lower limb were treated with 4-hydroxyanisole (4HA) infused intra-arterially. 10 g of 4HA was infused twice per day up to a maximum dose of 80 g. 4HA infusion caused significant alterations in liver function which precluded completion of the treatment regimen in all but two patients. No tumour regression was observed in any patient. We cannot recommend this technique for managing patients with recurrent cutaneous MM.
authors.affiliation: Department of Plastic Surgery, West Norwich Hospital, Norfolk.
authors.forename: H J
authors.initials: HJ
authors.lastname: Belcher
authors.forename: M
authors.initials: M
authors.lastname: Nizam
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Neill
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000840:Anisoles / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000840:Anisoles; D000970:Antineoplastic Agents; C009760:mequinol