The effect of the synthetic lecithin analogue, dimethyl-DL-2, 3-distearolyoxypropyl-2'hydroxylethylammonium acetate, on cytolytic T lymphocyte (CTL) activity.
The effect of the synthetic lecithin analogue, dimethyl-DL-2, 3-distearolyoxypropyl-2'hydroxylethylammonium acetate, on CTL cytolytic activity was studied. The analogue significantly inhibits H-2b anti H-2d cytolytic T lymphocytes at concentrations which do not impair lymphocyte viability, protein synthesis, or RNA synthesis. At these concentrations the inhibition is reversible upon removing the analogue. Thus, the inhibition produced by analogue simply is not a result of analogue toxicity. At higher concentrations of the analogue, CTL inhibition is very pronounced; however at these higher concentrations there is evidence of non-specific toxicity of the analogue on CTL.
Lindquist
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University of Connecticut School of Medicine, Farmington 06030.
D000818:Animals; D002478:Cells, Cultured; D051379:Mice; D008810:Mice, Inbred C57BL; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010741:Phospholipases A / Q000502:physiology; D014176:Protein Biosynthesis; D013228:Stearates; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects*
D010713:Phosphatidylcholines; D013228:Stearates; C015161:Rosenthal's inhibitor; D010741:Phospholipases A