title: Effects of trazodone on EEG sleep and clinical state in major depression.
abstract: The effects of the antidepressant trazodone on clinical state and on EEG sleep in eight outpatients with a major depressive disorder were investigated in a single blind study. A medication period of 5 weeks was preceded and followed by one week placebo treatment. Five subjects showed a positive treatment response. Trazodone did not influence sleep continuity and slow wave sleep, but did suppress REM sleep significantly. A significant increase of REM sleep latency was also found. These results are in contrast with earlier reports on trazodone's effects on EEG sleep but are in accordance with the general finding that antidepressants influence REM sleep characteristics without necessarily affecting sleep continuity.
authors.affiliation: Department of Clinical Psychiatry, University of Limburg, Maasstricht, The Netherlands.
authors.forename: A L
authors.initials: AL
authors.lastname: van Bemmel
authors.forename: R G
authors.initials: RG
authors.lastname: Havermans
authors.forename: R
authors.initials: R
authors.lastname: van Diest
mesh_terms: D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D016037:Single-Blind Method; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects; D014196:Trazodone / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014196:Trazodone