[Cerebrospinal fluid cytology in meningeal invasion of leukemia and malignant lymphoma. Reliable diagnosis by immunocytochemistry].
Cerebrospinal fluid cytology was performed in 64 patients who were suspected of having a meningeal infiltration of malignant lymphoma or leukemia. Conventional staining with May Grünwald Giemsa revealed a positive result in 51 cases, and a negative result in one case. In 4 cases diagnosis was hampered by blood contamination or a lack of CSF cells. In the remaining 8 cases with doubtful cytologic specimens, additional immunocytochemic staining allowed definite diagnosis. In 5 of these cases malignancy was confirmed, while in the remaining 3 an inflammatory cell pattern was found and later confirmed by follow-up. In summary, immunocytochemistry was essential for definite diagnosis in 12% of CSF cell specimens suspected of leukemia or malignant lymphoma. It may be concluded that immunocytochemistry in CSF cytology is a valuable tool for enhancement of diagnostic reliability.
Bamborschke
S
S
Klinik und Poliklinik für Neurologie und Psychiatrie Universität Köln.
Huber
M
M
D000328:Adult; D014408:Biomarkers, Tumor / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000556:secondary*
D014408:Biomarkers, Tumor
Liquorzytologie bei meningealer Aussaat von Leukämien und malignen Lymphomen. Sichere Diagnose durch Immunzytochemie.