Ifosfamide in plasma cell leukemia: a report of two cases and review of the literature.
We report two patients with primary plasma cell leukemia (PLC) treated with a single agent, ifosfamide. One patient had a total disappearance of plasma cells (PC) from the peripheral blood and the bone marrow and disappearance of the myeloma protein, is disease free 8 months after completion of treatment, and alive 14 months after diagnosis. The second patient had a partial response with persistence of plasma cells in the bone marrow lasting 7 months, after which she had a frank relapse of the disease. We suggest that ifosfamide may be an active agent in plasma cell malignancies and needs further evaluation in multiple myeloma.
Malhotra
H
H
Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
Dhabhar
B N
BN
Saikia
T K
TK
Gopal
R
R
Nadkarni
K S
KS
Nair
C N
CN
Advani
S H
SH
D000328:Adult; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D007952:Leukemia, Plasma Cell / Q000188:drug therapy*; D008875:Middle Aged
D007069:Ifosfamide