Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements during maintenance haloperidol treatment in male patients with schizophrenia.
Measurement of plasma prolactin (PRL) concentration and plasma homovanillic acid (HVA) concentration was performed in 24 patients with schizophrenia during maintenance haloperidol treatment. A significant inverse correlation was found between plasma PRL and ratings of both dyskinesia and thought disorder. Plasma PRL was also correlated with negative symptoms. No relationship was found between plasma HVA and any symptom grouping. Twelve patients received an apomorphine challenge; a trend toward a significant inverse relationship was found between baseline dyskinesia and apomorphine-induced decreases in plasma PRL. Plasma PRL and plasma HVA may reflect different elements of dopamine function in the central nervous system during maintenance treatment; plasma PRL may be the useful marker under these conditions.
Newcomer
J W
JW
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Riney
S J
SJ
Vinogradov
S
S
Csernansky
J G
JG
D000328:Adult; D000368:Aged; D001058:Apomorphine; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004409:Dyskinesia, Drug-Induced / Q000097:blood / Q000175:diagnosis* / Q000523:psychology; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects*; D006719:Homovanillic Acid / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011388:Prolactin / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D011954:Receptors, Dopamine; D011388:Prolactin; D006220:Haloperidol; D001058:Apomorphine; D006719:Homovanillic Acid