The effects of intraocular gases on rabbit blood-retinal barrier permeability.
The effects of intravitreal expansile gases, sulfur hexafluoride and octafluoropropane, as well as air and needle insertion alone were assessed by iris fluorescein angiography and blood-retinal barrier permeability determination. Iris angiography, at 3 days after injection, indicated no differences between experimental and paired control eyes. Vitreous fluorophotometry on day 1, day 4 and day 7 after gas or sham injection also showed no differences between paired control and experimental eyes regardless of which experimental condition was employed. The results indicate that these gases are non-toxic to the blood-retinal barrier over a 7 day time course.
Green
K
K
Department of Ophthalmology, Medical College of Georgia, Augusta 30912.
Slagle
T
T
Cheeks
L
L
Norman
B C
BC
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001813:Blood-Retinal Barrier / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects*; D019793:Fluorescein; D005451:Fluorescein Angiography; D005452:Fluoresceins / Q000008:administration & dosage; D005466:Fluorocarbons / Q000494:pharmacology*; D015590:Fluorophotometry; D007498:Iris / Q000098:blood supply; D011817:Rabbits; D013459:Sulfur Hexafluoride / Q000494:pharmacology*; D014822:Vitreous Body / Q000378:metabolism
D005452:Fluoresceins; D005466:Fluorocarbons; C042852:perflutren; D019793:Fluorescein; D013459:Sulfur Hexafluoride