Preparation of poly (D,L) lactide microspheres by emulsion-solvent evaporation, and their clinical applications as a convenient embolic material.
The aim of preoperative embolization is to facilitate surgical removal by reducing tumor volume and vascularity, thereby decreasing blood loss during surgery. In a search for a better embolic material, compared to heterogeneous commercial products, we describe here in detail the preparation of poly (D,L) lactide microspheres by an emulsion-solvent evaporation process. The size distribution of the microparticles and their aggregation state--critical parameters in view of such application--have been investigated. Their effectiveness, as an embolic material, has been evaluated by some preliminary experiments undertaken on humans. The results were assessed on clinical and histological grounds.
Grandfils
C
C
Department of Macromolecular Chemistry and Organic Catalysis, University of Liège, Belgium.
Flandroy
P
P
Nihant
N
N
Barbette
S
S
Jérome
R
R
Teyssié
P
P
Thibaut
A
A
D004621:Embolization, Therapeutic; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008863:Microspheres; D011091:Polyesters
D011091:Polyesters; C033616:poly(lactide)