title: Insulin dosage adjustment in diabetes.
abstract: A prototype computer system has been developed to provide advice on the day-to-day adjustment of carbohydrate intake and insulin regimen in the insulin-treated diabetic patient. The system also produces a 24-hour simulation of the patient's blood glucose profile based on these adjustments. Advice is generated by a qualitative knowledge-based system which suggests what the next step in improving glycaemic control might be for a given patient, e.g. 'decrease evening medium-acting insulin by two units'. Simulations are provided by a non-linear model which consists of a one-compartment glucose model linked to a model with plasma and 'active' insulin compartments. A description of the integrated system is provided and its operation illustrated by clinical case studies from insulin-treated diabetic patients.
authors.affiliation: Department of Endocrinology and Chemical Pathology, United Medical School, St. Thomas' Hospital, London, UK.
authors.forename: E D
authors.initials: ED
authors.lastname: Lehmann
authors.forename: T
authors.initials: T
authors.lastname: Deutsch
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004360:Drug Therapy, Computer-Assisted; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D007328:Insulin