title: Cerebral blood flow velocity in normal, full-term newborns is not related to ductal closure.
abstract: OBJECTIVE
  To correlate changes in blood flow velocity in the anterior and middle cerebral arteries with closure of the ductus arteriosus in normal, full-term newborns during the first 2 days following delivery.
  
  
  METHODS
  Survey.
  
  
  METHODS
  Large community hospital.
  
  
  METHODS
  Twenty-three normal, full-term neonates.
  
  
  METHODS
  Volunteer sample.
  
  
  METHODS
  None.
  
  
  RESULTS
  We measured blood flow velocity in the anterior and middle cerebral arteries, cardiac output, and patency of the ductus arteriosus using pulsed Doppler, M-mode, and real-time ultrasound. The initial examination was performed at (mean +/- SD) 7.6 +/- 2 hours and the second examination was performed at 30 +/- 3 hours. The systolic, diastolic, and mean blood flow velocity in the anterior and middle cerebral arteries increased significantly from day 1 to day 2. Cardiac output did not change significantly (252 +/- 49 vs 279 +/- 69 cm3/kg per minute). Thirteen newborns on day 1, but only two newborns on day 2, had echocardiographic evidence of a patent ductus arteriosus. Newborns whose ductus was already closed on day 1 had similar increases in blood flow velocity in the anterior and middle cerebral arteries from day 1 to day 2 compared with newborns whose ductus had closed from day 1 to day 2.
  
  
  CONCLUSIONS
  The normal increase in blood flow velocity in the anterior and middle cerebral arteries in the first 2 days following delivery is not related to changes in cardiac output or ductal closure.
authors.affiliation: Department of Pediatrics, William Beaumont Hospital, Royal Oak, Mich 48073-6769.
authors.forename: D G
authors.initials: DG
authors.lastname: Batton
authors.forename: S
authors.initials: S
authors.lastname: Riordan
authors.forename: T
authors.initials: T
authors.lastname: Riggs
mesh_terms: D001011:Aorta / Q000033:anatomy & histology; D001783:Blood Flow Velocity; D002302:Cardiac Output; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D003971:Diastole; D004373:Ductus Arteriosus / Q000000981:diagnostic imaging / Q000502:physiology*; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005069:Evaluation Studies as Topic; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D013318:Stroke Volume; D013599:Systole; D013997:Time Factors