title: High-speed rotational angioplasty-induced echo contrast in vivo and in vitro optical analysis.
abstract: High-speed rotational angioplasty is being evaluated as an alternative interventional device for the endovascular treatment of chronic coronary occlusions. It has been postulated that this type of angioplasty device may produce particulate debris or cavitations that induce myocardial ischemia. To determine the clinical presence of myocardial ischemia during rotational angioplasty, echocardiographic monitoring for wall motion abnormalities was performed in 9 patients undergoing rotational atheroablation using the Auth Rotablator for 10-sec intervals at 150,000 and 170,000 rpm. No wall motion abnormalities were detected in 5 patients evaluated with transesophageal echocardiography or in 4 patients monitored transthoracically, although AV block developed in one patient. Video intensitometry of the myocardial contrast effect for rotation times ranging from 3 to 20 sec found transient contrast enhancement of the myocardium supplied by the treated vessel. Intensity varied over time with half-time decay between 5.6 and 40 sec, indicating the likelihood of microcavitation. An in vitro model was constructed to measure the cavitation potential of the Auth Rotablator. A burr of 1.25 mm diameter rotating at 160,000 rpm achieves a velocity in excess of the 14.7 m/sec critical cavitation velocity. Testing the device in fresh human blood and distilled water produced microcavitations responsible for the enhanced echo effect, with the intensity and longevity of cavitation more pronounced in blood and proportional to the rotation time and speed. The mean size of the microcavitation bubbles in water was 90 +/- 33 (52-145) microns measured from photographs taken with a copper vapour laser emitting light pulses of 50 nsec duration as light source. The mean velocity of bubbles was found to be 0.62 +/- 0.30 ranging from 0.23 to 1.04 m/sec. It was measured via the motion of the bubbles during 5 laser pulses within 800 nsec. Clearly, microcavitations are associated with enhanced myocardial echo contrast effect.
authors.affiliation: II. Medical Clinic, Johannes Gutenberg University, Mainz, Germany.
authors.forename: R J
authors.initials: RJ
authors.lastname: Zotz
authors.forename: R
authors.initials: R
authors.lastname: Erbel
authors.forename: A
authors.initials: A
authors.lastname: Philipp
authors.forename: A
authors.initials: A
authors.lastname: Judt
authors.forename: H
authors.initials: H
authors.lastname: Wagner
authors.forename: W
authors.initials: W
authors.lastname: Lauterborn
authors.forename: J
authors.initials: J
authors.lastname: Meyer
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D002302:Cardiac Output / Q000502:physiology; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D004452:Echocardiography / Q000295:instrumentation*; D004867:Equipment Design; D006452:Hemoglobinometry; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D013929:Thromboxane B2 / Q000097:blood; D014741:Video Recording / Q000295:instrumentation*
chemical_list: D013929:Thromboxane B2; D007770:L-Lactate Dehydrogenase