Monoclonal antibody immunoconjugates in the diagnosis and treatment of advanced melanoma.
It appears that monoclonal antibody immunoconjugates may have a role in the radioimmunodiagnosis of melanoma. The precise method of administering the immunoconjugate still remains to be defined. Also evident is the possibility of treating patients with metastatic melanoma with repeated doses of a monoclonal antibody ricin A-chain immunotoxin, but appropriate dosing schedules of the immunotoxin need to be explored further. The agents selected for suppressing the immune response need further study.
Bhardwaj
S
S
Department of Neoplastic Diseases, Mount Sinai Medical Center, New York, New York 10029.
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006801:Humans; D007159:Immunologic Tests; D000922:Immunotoxins / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D012276:Ricin / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; C059257:XomaZyme; D012276:Ricin