Amelioration of cardiodepressive effects of gadopentetate dimeglumine with addition of ionic calcium.
Doses of gadopentetate dimeglumine of 0.1-0.5 mmol/kg cause cardiodepressive effects when injected as a rapid central bolus into the left jugular vein. This study evaluated the hemodynamic effects of this magnetic resonance imaging contrast medium with and without calcium supplementation in a rat model. Also, the potential of gadopentetate dimeglumine to bind ionized serum calcium was investigated in vitro. Addition of calcium ions resulted in dose-dependent attenuation of the hemodynamic depression induced by gadopentetate dimeglumine alone. The cardiodepressive response was negated for a 0.1-mmol/kg dose of the contrast agent by addition of 6 mumol/kg of calcium, for a 0.3-mmol/kg dose by addition of 12 mumol/kg of calcium, and for a 0.5-mmol/kg dose by addition of 18 mumol/kg of calcium. Concentrations of 2 and 4 mmol/L of gadopentetate dimeglumine were found to bind 5.1% and 10.1% of the ionized calcium in rat serum under in vitro conditions, respectively.
Mühler
A
A
Department of Radiology, University of California, San Francisco 94143-0628.
Saeed
M
M
Brasch
R C
RC
Higgins
C B
CB
D000818:Animals; D002118:Calcium / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D003287:Contrast Media / Q000494:pharmacology*; D004338:Drug Combinations; D005260:Female; D005682:Gadolinium / Q000494:pharmacology*; D019786:Gadolinium DTPA; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D007477:Ions; D008297:Male; D008536:Meglumine / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D004369:Pentetic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D003287:Contrast Media; D004338:Drug Combinations; D007477:Ions; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA; D002118:Calcium