Necrobiosis lipoidica: treatment with systemic corticosteroids.
In an attempt to find an effective therapy for necrobiosis lipoidica, we have treated six patients with this disease with a 5-week course of systemic corticosteroids. This treatment resulted in complete cessation of disease activity in all patients and no recurrence in a mean follow-up period of 7 months; however, restitution of atrophic skin lesions could not be achieved. The therapy was well tolerated and did not pose problems, even in diabetic patients. These results strongly suggest that short-course therapy of necrobiosis lipoidica with corticosteroids is of lasting benefit to these patients and should probably be considered early in the course of their skin disease.
Petzelbauer
P
P
Department of Dermatology I, University of Vienna Medical School, Austria.
Wolff
K
K
Tappeiner
G
G
D000284:Administration, Oral; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000188:drug therapy* / Q000473:pathology
D008775:Methylprednisolone