title: Recombinant globulins: novel research tools and possible pharmaceuticals.
abstract: A novel approach to the study of proteins is the construction of chimeras consisting of a target protein fused to an immunoglobulin constant domain. These recombinant globulins have been used in the identification of ligand-receptor pairs, determination of functional consequences of receptor engagement, the elucidation of structural domains necessary for ligand binding, and as potential therapeutic agents.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington.
authors.forename: D
authors.initials: D
authors.lastname: Hollenbaugh
authors.forename: N J
authors.initials: NJ
authors.lastname: Chalupny
authors.forename: A
authors.initials: A
authors.lastname: Aruffo
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002678:Chimera / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D008024:Ligands; D011993:Recombinant Fusion Proteins / Q000276:immunology; D012106:Research; D013329:Structure-Activity Relationship
chemical_list: D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D008024:Ligands; D011993:Recombinant Fusion Proteins