[Inhibition of photosensitization of morin on DNA synthesis of ascites hepatoma cells].
Morin (0.012, 0.12, 1.2, 12.0 micrograms.ml-1) significantly inhibited the DNA synthesis of ascitic hepatoma (AH) cells. The inhibition of DNA synthesis and cell mortality was dependent on its concentrations as well as the illumination time. Photosensitization of morin was not due to 1O2 and O2-, but closely related to OH. and H2O2. The mechanism of the inhibition may be attributed to the damage of DNA replication template.
Zhou
X F
XF
Department of Biology, Lanzhou University, China.
Zheng
R L
RL
Huang
M
M
D000818:Animals; D004273:DNA, Neoplasm / Q000096:biosynthesis* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers; D008114:Liver Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D047309:Flavones
D004273:DNA, Neoplasm; D005419:Flavonoids; D016166:Free Radical Scavengers; D011838:Radiation-Sensitizing Agents; C008548:morin; D047309:Flavones