Elevated serum manganese superoxide dismutase in acute leukemias.
We measured the serum levels of manganese-superoxide dismutase (Mn-SOD) in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Serum Mn-SOD level for normal subjects was 94.1 +/- 23.5 ng/ml (mean +/- S.D.), the levels for AML and ALL patients were 159.6 +/- 77.1 ng/ml and 154.4 +/- 77.0 ng/ml, respectively. The serum Mn-SOD levels were unrelated to individual intracellular Mn-SOD levels, but correlated well with serum lactate dehydrogenase values. Regression of the leukemia was accompanied by decrease in the serum level of Mn-SOD. Serum Mn-SOD may thus serve as a measure of the activity of the disease.
Nishiura
T
T
Department of Biochemistry, Osaka University Medical School, Japan.
Suzuki
K
K
Kawaguchi
T
T
Nakao
H
H
Kawamura
N
N
Taniguchi
M
M
Kanayama
Y
Y
Yonezawa
T
T
Iizuka
S
S
Taniguchi
N
N
D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology*; D009000:Monocytes / Q000201:enzymology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood*
D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase