Cytometric haematological analysis of experimental Yersinia pseudotuberculosis infection at temperatures of cultivation of 25 degrees C and 37 degrees C.
The dynamics of acute lethal infection with Yersinia pseudotuberculosis (serovar III) grown at 25 degrees C and 37 degrees C, respectively, were studied in guinea-pigs. Using an automated hematology analyzer, the quantity and quality of the host cellular response was determined at the primary site of infection (the peritoneal cavity) and in parallel in the blood. A much more intensive leucocytic response of monocytic type was observed in the animals infected with microorganism grown at 37 degrees C. This type of reaction was associated with a lower mortality rate and a relatively benign progression of the infection.
Markova
N
N
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
Najdenski
H
H
Veljanov
D
D
Petkova
V
V
Shishkova
N
N
D000818:Animals; D016470:Bacteremia / Q000097:blood* / Q000401:mortality; D005260:Female; D006168:Guinea Pigs; D007958:Leukocyte Count; D008099:Liver / Q000382:microbiology; D008297:Male; D010529:Peritoneal Cavity / Q000166:cytology; D013696:Temperature; D015011:Yersinia pseudotuberculosis / Q000254:growth & development; D015012:Yersinia pseudotuberculosis Infections / Q000097:blood* / Q000401:mortality