title: Cerebral hemodynamics and cerebral blood volume: MR assessment using gadolinium contrast agents and T1-weighted Turbo-FLASH imaging.
abstract: OBJECTIVE
  To assess the degree and regional pattern of first-pass brain enhancement using dynamic MR imaging.
  
  
  METHODS
  Ultrafast MR imaging (1.06-second acquisition time per image) was performed in 19 healthy subjects following a bolus IV injection of a gadolinium contrast agent; 36 patients with suspected pathology were studied using the same protocol.
  
  
  RESULTS
  Calculated percent blood volumes were 4.9% for right cortical gray matter, 4.8% for left cortical gray matter, and 2.6% for white matter. Subtraction images were obtained that depicted the first pass "blood pool" pattern of enhancement (gray and white matter) which was significant.
  
  
  CONCLUSIONS
  Preliminary evidence suggests utility for cerebral "blood pool" imaging, especially if reduced image acquisition times can be achieved.
authors.affiliation: Barrow Neurological Institute, St. Joseph Hospital and Medical Center, Phoenix, AZ 85013.
authors.forename: B L
authors.initials: BL
authors.lastname: Dean
authors.forename: C
authors.initials: C
authors.lastname: Lee
authors.forename: J E
authors.initials: JE
authors.lastname: Kirsch
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: R M
authors.initials: RM
authors.lastname: Dempsey
authors.forename: L C
authors.initials: LC
authors.lastname: Pettigrew
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D019786:Gadolinium DTPA