title: Cognitive profile in adult, normal intelligent female fragile X carriers.
abstract: Here we present the results of the study of the cognitive profile of 11 adult, normally intelligent female fragile X [fra(X)] carriers. In all individuals 3 types of testing were performed: full scale Wechsler Adult Intelligence Scale, a set of neuropsychological tests and an arithmetic achievement test. All 11 subjects showed an average to above-average intelligence but 10 of 11 performed better on the performance than on the verbal subscale. Neuropsychological tests suggest a dysfunction of the reticulo-thalamic axis with deficiency on tests requiring visual memory and a pronounced deficiency of attention skills combined with an impulsive way of completing tests.
authors.affiliation: Division of Child Psychiatry, University of Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Steyaert
authors.forename: M
authors.initials: M
authors.lastname: Borghgraef
authors.forename: C
authors.initials: C
authors.lastname: Gaulthier
authors.forename: J P
authors.initials: JP
authors.lastname: Fryns
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D003071:Cognition; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics / Q000523:psychology*; D006579:Heterozygote; D006801:Humans; D007360:Intelligence; D008433:Mathematics; D009483:Neuropsychological Tests; D014888:Wechsler Scales