Diazepam binding inhibitor processing in the rhesus monkey brain: an immunocytochemical study.
Immunocytochemical methods were used to study the regional and cellular distribution of diazepam binding inhibitor (DBI)-, ODN (DBI 33-50)- and TTN (DBI 17-50)-like immunoreactivity (LI) in monkey brain. DBI-, ODN- and TTN-LI were found to have similar regional but different cellular distributions. The most intense staining was detected in limbic structures, especially the amygdala. The most notable staining discrepancy was the weak-to-moderate uniform DBI-LI and the very high patchy ODN-LI and TTN-LI in the ventral striatum. At the cellular level, DBI-LI was preferentially localized in glia-like cells, whereas ODN-LI and TTN-LI were mainly found in neurons.
Slobodyansky
E
E
Fidia-Georgetown Institute for the Neurosciences, Georgetown University School of Medicine, Washington, DC 20007.
Kurriger
G
G
Kultas-Ilinsky
K
K
D000679:Amygdala / Q000737:chemistry; D000818:Animals; D001923:Brain Chemistry; D001933:Brain Stem / Q000737:chemistry; D003342:Corpus Striatum / Q000737:chemistry; D026261:Diazepam Binding Inhibitor; D006624:Hippocampus / Q000737:chemistry; D007124:Immunoenzyme Techniques; D008253:Macaca mulatta; D009457:Neuroglia / Q000737:chemistry; D009474:Neurons / Q000737:chemistry*; D009479:Neuropeptides / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis*; D013378:Substantia Nigra / Q000737:chemistry
D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D010446:Peptide Fragments; C067529:diazepam binding inhibitor (33-50); C060941:triakontatetraneuropeptide