The effects of beta-endorphin infusions into the amygdala on visual and olfactory sensory processing during sexual behaviour in the male rat.
Sexually experienced male rats infused bilaterally into the amygdala with 60 pmol beta-endorphin show decreased rate of precopulatory investigation of the female and delayed intromission latency, but copulation is left unaltered. Such males are still able to discriminate between the odours of bedding from receptive and unreceptive females, demonstrating that beta-endorphin does not impair the ability to detect sexually relevant odours. Preventing visual cues emitted by females during proceptive behaviour (by treating them with haloperidol) delayed intromission latency but had no effect on preintromission investigation. Intra-amygdaloid beta-endorphin exacerbated the effects of this treatment on the intromission latency. Inducing anosmia in males (by applying zinc sulphate solution to the olfactory mucosa) decreased their anogenital investigation and delayed their intromission latency. These effects were not enhanced by intra-amygdaloid beta-endorphin. Allowing males to investigate and initiate the first intromission prior to intra-amygdaloid infusion had no effects on subsequent intromissions. However, if following an intromission with one female and an infusion of beta-endorphin, the male was presented with an unfamiliar female then the effects of intra-amygdaloid beta-endorphin on investigation and intromission returned. These results suggest that beta-endorphin in the amygdala interferes with the processing of female-specific olfactory information. Without this processed information, classification of the female as a sexual stimulus may be impeded and thus sexual arousal delayed.
McGregor
A
A
Department of Anatomy, University of Cambridge, U.K.
Herbert
J
J
D000679:Amygdala / Q000033:anatomy & histology; D000818:Animals; D003463:Cues; D004192:Discrimination, Psychological / Q000187:drug effects; D005260:Female; D007267:Injections; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D000857:Olfaction Disorders / Q000523:psychology; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012903:Smell / Q000502:physiology*; D013431:Sulfates / Q000494:pharmacology; D014785:Vision, Ocular / Q000502:physiology*; D015032:Zinc / Q000494:pharmacology; D019287:Zinc Sulfate; D001615:beta-Endorphin / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000494:pharmacology*
D013431:Sulfates; D001615:beta-Endorphin; D019287:Zinc Sulfate; D015032:Zinc