title: Effects of lesions of locus coeruleus/subcoeruleus on diffuse noxious inhibitory controls in the rat.
abstract: Diffuse noxious inhibitory controls (DNIC) acting on trigeminal convergent neurons were compared in sham-operated animals and rats with quinolinic acid induced lesions of the locus coeruleus/subcoeruleus (LC/SC). No significant differences were observed between control animals and those with ipsilateral, contralateral or bilateral lesions of the LC/SC, in respect of: (1) the general properties of the recorded units; and (2) the magnitude of the depressions of C-fiber-evoked responses of convergent neurons produced by immersing each paw in a 50 degrees C water bath (i.e. DNIC). It is concluded that the LC/SC is not involved, at least directly, in the supraspinal part of the loop which subserves DNIC in the rat.
authors.affiliation: I.N.S.E.R.M. U.161, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Bouhassira
authors.forename: Z
authors.initials: Z
authors.lastname: Bing
authors.forename: D
authors.initials: D
authors.lastname: Le Bars
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D004594:Electrophysiology; D005528:Foot; D007101:Immersion; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D014279:Trigeminal Nucleus, Spinal / Q000166:cytology / Q000502:physiology