title: [Mutilans type of rheumatoid arthritis].
abstract: In order to investigate the clinical and pathological features of arthritis mutilans, the clinical history, activity of inflammation, histological findings and treatment have been studied on the basis of follow-up of rheumatoid arthritis (RA) patients with arthritis mutilans. A high incidence of arthritis mutilans was observed in rheumatoid patients who have a younger onset, longer history and higher activity of RA without specific pathophysiological features. Joint destruction may further progress in arthritis mutilans despite intensive treatment with disease modifying anti-rheumatic drugs (DMARDs), and multi-joint replacement may be required in the patients with this type of arthritis.
authors.affiliation: Department of Orthopaedic Surgery, Kobe University School of Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Saura
authors.forename: T
authors.initials: T
authors.lastname: Matsubara
authors.forename: K
authors.initials: K
authors.lastname: Hirohata
mesh_terms: D000293:Adolescent; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000473:pathology; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging