[Effect of heparin and/or antithrombin III in a model of disseminated intravascular coagulation induced by endotoxin in rabbits].
Disseminated intravascular coagulation (DIC) was induced in 84 rabbits by intravenous infusion of 20 micrograms/kg/h of endotoxin during 6 hours. The following treatments were administered simultaneously with endotoxin: heparin, 5, 10 and 20 UI/kg/h, antithrombin III (AT III), 10, 20 and 40 U/kg/h or as a 240 U/kg bolus dose, and heparin (10 UI/kg/h) plus AT III (20 U/kg/h). Blood samples were taken before endotoxin and 2 and 6 hours after endotoxin to perform screening coagulation assays, factors V, VIII and XII, AT III, fibrin monomers and fibrinogen degradation products. All treatments were able to modify some of the parameters related to DIC, but only AT III bolus dose and heparin plus AT III significantly reduced fibrin deposition in kidneys (p less than 0.05). All the therapeutic schedules significantly diminished the mortality rate. We conclude that AT III bolus dose and heparin plus AT III are useful in the treatment of endotoxin-induced intravascular coagulation in rabbits.
Gómez
C
C
Servicio de Hematología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Páramo
J A
JA
Rocha
E
E
D000818:Animals; D000990:Antithrombin III / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D005337:Fibrin / Q000378:metabolism; D006493:Heparin / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D012772:Shock, Septic / Q000097:blood / Q000150:complications*
D000990:Antithrombin III; D005337:Fibrin; D006493:Heparin
Efecto de la heparina y/o antitrombina III en un modelo de coagulacíon intravascular diseminada inducida por endotoxina en conejos.