Effects of the dopamine antagonist (+)-SCH 23390 on intracellularly recorded responses of ganglion cells in the rabbit retina.
The effects of the dopamine D1 antagonist (+)-SCH 23390 on the responses of ganglion cells in the superfused rabbit retinal preparation were studied by intracellular recording. At low micromolar concentrations, (+)-SCH 23390 hyperpolarized OFF-center brisk ganglion cells and reduced or abolished any spontaneous spike activity that was present. The light-evoked EPSPs at the onset of a spot or annulus were reduced or abolished, while the EPSPs at light offset were in most cases potentiated. (+)-SCH 23390 depolarized ON-center brisk ganglion cells and increased spontaneous spike activity. The light-evoked EPSPs to spots and annuli were either unaffected or reduced roughly to the same extent. The findings in this study are compared with findings in a recent study in which the effects of (+)-SCH 23390 on the extracellularly recorded responses of ganglion cells in the rabbit retina were examined.
Jensen
R J
RJ
Department of Biomedical Sciences, Southern College of Optometry, Memphis, TN 38104.
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D004594:Electrophysiology; D007736:Kynurenic Acid / Q000494:pharmacology; D011817:Rabbits; D012165:Retinal Ganglion Cells / Q000187:drug effects / Q000502:physiology*
D001552:Benzazepines; D007736:Kynurenic Acid