title: Lymphoma of ovary with stromal luteinization, presenting as secondary amenorrhea.
abstract: A case of primary lymphoma of the ovary with extensive stromal luteinization is presented. Immunohistochemical markers that work satisfactorily in fixed tissues allowed a diagnosis of B cell lymphoma to be made on formalin-fixed tissue sections. Immunohistochemical analysis of frozen tissue and genotypic analysis confirmed the diagnosis of B cell lymphoma. By electron microscopy two populations of cells, including large atypical lymphoid cells and luteinized stromal cells, were identified. Presentation with amenorrhea and resumption of menstrual periods after removal of the tumor suggested the possibility of functional activity in the luteinized stromal cells. Stromal luteinization has not been previously described in primary ovarian lymphoma.
authors.affiliation: Department of Pathology, New York University Medical Center, New York.
authors.forename: K R
authors.initials: KR
authors.lastname: Mittal
authors.forename: A
authors.initials: A
authors.lastname: Blechman
authors.forename: M A
authors.initials: MA
authors.lastname: Greco
authors.forename: F
authors.initials: F
authors.lastname: Alfonso
authors.forename: R
authors.initials: R
authors.lastname: Demopoulos
mesh_terms: D000328:Adult; D000568:Amenorrhea / Q000175:diagnosis* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D015139:Blotting, Southern; D004273:DNA, Neoplasm / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008183:Luteal Phase; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008854:Microscopy, Electron; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm