Kainic acid lesion of the striatum increases dopamine release but reduces 3-methoxytyramine level.
Kainic acid lesion of the striatum leads to the disruption of the striatonigral regulatory loop. Although microdialysis showed an increase in dopamine release, two days after kainic acid injection, 3-methoxytyramine levels are dramatically decreased. This suggests that the postsynaptic membrane-bound catechol-O-methyltransferase (COMT), but not the glial COMT, is responsible for the formation of measured 3-methoxytyramine.
Naudon
L
L
Unité de Neuropsychopharmacologie Expérimentale, U.R.A. 1170 du CNRS, Faculté de Médecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
Dourmap
N
N
Leroux-Nicollet
I
I
Costentin
J
J
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000502:physiology*; D003956:Dialysis; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007608:Kainic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D015102:3,4-Dihydroxyphenylacetic Acid; D002394:Catechol O-Methyltransferase; C001746:3-methoxytyramine; D007608:Kainic Acid; D004298:Dopamine; D006719:Homovanillic Acid