Equine glomerulonephritis and renal failure associated with complexes of group-C streptococcal antigen and IgG antibody.
A 12-year-old thoroughbred gelding died from diffuse global glomerulonephritis, 3 months after a lower respiratory infection from which Streptococcus zooepidemicus was isolated. Immunopathological studies (immunofluorescence, immunodiffusion, immunoperoxidase testing and immunoblotting) indicated the presence of an immune reactant renal disease associated with IgG antibody and streptococcal antigens.
Divers
T J
TJ
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Timoney
J F
JF
Lewis
R M
RM
Smith
C A
CA
D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis*; D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D006734:Horse Diseases / Q000276:immunology* / Q000382:microbiology; D006736:Horses; D005779:Immunodiffusion; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis*; D007672:Kidney Cortex / Q000276:immunology; D007676:Kidney Failure, Chronic / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D008171:Lung Diseases / Q000276:immunology / Q000382:microbiology / Q000662:veterinary; D013290:Streptococcal Infections / Q000276:immunology / Q000662:veterinary*
D000942:Antigens, Bacterial; D003176:Complement C3; D007074:Immunoglobulin G