title: Slowly progressive familial dementia with recurrent strokes and white matter hypodensities on CT scan.
abstract: We describe 2 normotensive sisters presenting slowly progressive dementia associated with acute or subacute focal neurological symptoms, unilateral or bilateral motor signs, and dysarthria. Their father, who died in the seventh decade, had a similar clinical picture. Computerized axial tomography (CT) scan of the head showed symmetrical hypodensities in the periventricular white matter and mild to moderate hydrocephalus. In these patients a diagnosis of Binswanger's disease was based on the clinical features supported by white matter changes on CT scan. Our study suggests that genetic factors may play a role in the etiology of Binswanger's disease.
authors.affiliation: Clinica Neurologica Università di Bologna, Ospedale Bellaria.
authors.forename: F
authors.initials: F
authors.lastname: Salvi
authors.forename: R
authors.initials: R
authors.lastname: Michelucci
authors.forename: R
authors.initials: R
authors.lastname: Plasmati
authors.forename: L
authors.initials: L
authors.lastname: Parmeggiani
authors.forename: P
authors.initials: P
authors.lastname: Zonari
authors.forename: M
authors.initials: M
authors.lastname: Mascalchi
authors.forename: C A
authors.initials: CA
authors.lastname: Tassinari
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000000981:diagnostic imaging / Q000523:psychology; D015140:Dementia, Vascular / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012008:Recurrence; D013577:Syndrome; D014057:Tomography, X-Ray Computed