Clotting abnormalities in chronic liver disease.
In patients with chronic liver disease (CLD), several clotting changes can be observed. The most frequent abnormality is the reduced synthesis of many clotting factors, including vitamin-K-dependent and vitamin-K-independent ones. A low platelet count is another frequent feature of patients with CLD, which, however, is not always associated with the prolongation of bleeding time. Hyperfibrinolytic syndrome is usually seen in patients with decompensated state, and may further deteriorate the clotting abnormalities and favor bleeding complications. The assessment of the clotting system may be a useful approach to evaluate liver function and predict prognosis of patients with CLD.
Violi
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Università degli Studi di Roma La Sapienza, Istituto di I Clinica Medica Generale, Italia.
Ferro
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Quintarelli
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Saliola
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M
Cordova
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C
Balsano
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D001778:Blood Coagulation Disorders / Q000209:etiology*; D001780:Blood Coagulation Tests; D001791:Blood Platelet Disorders / Q000209:etiology; D002908:Chronic Disease; D005342:Fibrinolysis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008107:Liver Diseases / Q000097:blood / Q000150:complications*; D010976:Platelet Count; D012307:Risk Factors; D013921:Thrombocytopenia / Q000209:etiology