title: [Manifestations and early course of type I diabetes mellitus--a decisive period from the viewpoint of controlling the further development of the disease].
abstract: The autoimmune process focused on B-cells of the islets of Langerhans and leading gradually to their destruction is latent before the manifestation of diabetic symptoms. The detection of this preclinical stage in particular in sporadic cases is in common clinical practice, due to the low prevalence of the disease in the population and pretentious character as regards applied methods, unreal. Therefore attention is focused on the period of clinical manifestation of the diabetic syndrome and its early stages when by early diagnosis and intensive insulin or immunosuppressive treatment it is still possible to preserve a substantial proportion of functional B-cells and influence in an effective manner the onset and duration of remission. The authors summarize experience assembled during the eighties, incl. therapeutic procedures and problems of active immunomodulation in the prehyperglycaemic stage of the disease.
authors.affiliation: Endokrinologický ústav, Praha.
authors.forename: K
authors.initials: K
authors.lastname: Vondra
authors.forename: T
authors.initials: T
authors.lastname: Merhaut
authors.forename: M
authors.initials: M
authors.lastname: Voborská
authors.forename: V
authors.initials: V
authors.lastname: Zamrazil
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D013997:Time Factors
vernacular_title: Manifestace a casný průbĕh diabetes mellitus I. typu--rozhodující období z hlediska moznosti ovlivnĕní dalsího vývoje onemocnĕní.