[Adenylate cyclase. A possible factor in the pathogenicity of Yersinia pestis].
Biological effect of homogenous preparation of Y. pestis adenylate cyclase on eucaryotic cells was studied. Adenylate cyclase, added (7.5 x 10(8) g/ml) to guinea pig macrophages lowers the level of chemiluminescence to 50-70%, has an appreciable cytotoxic effect on peritoneal macrophages and suppresses phosphorylation processes of leucocyte proteins from white mice. The experimental results obtained allow to suggest Y. pestis adenylate cyclase to be a pathogenic factor, contributing to the development of plague infection.
Michankin
B N
BN
Institut antipesteux, Rostov-Don, URSS.
Chevchenko
L A
LA
Asseeva
L E
LE
D000262:Adenylyl Cyclases / Q000494:pharmacology*; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006168:Guinea Pigs; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D051379:Mice; D010766:Phosphorylation; D015010:Yersinia pestis / Q000201:enzymology* / Q000472:pathogenicity
D000262:Adenylyl Cyclases
Adénylate-cyclase. Un éventuel facteur de la pathogénicité de Yersinia pestis.