Evaluation of epidermal growth factor receptor in squamous cell carcinoma of the oral cavity.
Forty-seven cases of oral squamous cell carcinoma were examined immunohistochemically by the avidin-biotin peroxidase complex method with anti-epidermal growth factor (EGF) receptor mouse monoclonal antibody, and 24 cases (51%) were shown to have EGF receptor-positive cells. Correlation was strong between presence of EGF receptors and differentiation; the EGF receptor-positive cells were differentiated, whereas poorly differentiated tumors exhibited less intense staining. EGF receptor gene and c-erb B-1 by Southern blot analysis disclosed that one of 25 cases of squamous cell carcinoma exhibited a fourfold amplification of the gene.
Yamada
T
T
First Department of Oral Surgery, Tokyo, Japan.
Takagi
M
M
Shioda
S
S
D015139:Blotting, Southern; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000235:genetics; D002454:Cell Differentiation; D066246:ErbB Receptors / Q000032:analysis*; D005784:Gene Amplification; D006801:Humans; D007124:Immunoenzyme Techniques; D009061:Mouth Mucosa / Q000737:chemistry; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000235:genetics; D014062:Tongue Neoplasms / Q000737:chemistry / Q000235:genetics
D066246:ErbB Receptors