[Acute myelogenous leukemia transformed from myelodysplastic syndrome with tetraploid chromosome constitution].
A 57-year-old female presented with general fatigue. She had neither lymphadenopathy nor hepatosplenomegaly. Laboratory data revealed anemia and leukopenia (1,500/microliters) with a differential count of 4.5% leukemic cells. The myelogram revealed 34.4% leukemic cells, of which diameter ranged from 20 to 28 microns. The diagnosis was acute myelogenous leukemia (FAB: M2) with myelodysplasia. Cytogenetic analysis revealed that the leukemic cells had chromosome abnormalities involving both diploidy and tetraploidy with structural rearrangement. Structural rearrangement included del(5) (q22q33), del(15) (q22q24), and t(3; 12) (q25;p13). Small dose aclacinomycin-A treatment was effective in reducing the number of leukemic cells in bone marrow, and both anemia and leukocytopenia were improved.
Furuya
H
H
Department of Internal Medicine, Shimane Medical University.
Tsuchiyama
S
S
Sato
T
T
Ishibashi
R
R
Notsu
K
K
Takagi
C
C
Yamamoto
H
H
Kato
Y
Y
D015250:Aclarubicin / Q000008:administration & dosage; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D011123:Polyploidy
D015250:Aclarubicin