title: On the computer-aided and optimal design of keratorefractive surgery.
abstract: BACKGROUND
  Several recent papers have discussed the use of engineering-based computer methods for the analysis of keratorefractive surgical procedures. What has been lacking is a broader view of the role of engineering analysis in keratorefractive surgery. This article demonstrates how these various analysis methods can be coupled to provide a comprehensive methodology for the design of refractive surgical procedures.
  
  
  METHODS
  A structural model of the eye, based on a linearly elastic, transversely isotropic finite element formulation is coupled to a full-eye optical model. The optical errors due to refractive keratotomy are estimated by ray tracing through the optical model and measuring the position of the resulting focal plane relative to the retina. Computer-based optimization methods are employed to determine the surgical parameters necessary to correct myopia for a given set of surgical design goals.
  
  
  RESULTS
  Results based on a hypothetical eye demonstrate agreement with clinical trends. Radial keratotomies are designed that eliminate refractive error while minimizing invasiveness in one case and maximizing the optical zone size in another. It is also shown that there is significant potential to customize this process on a patient-by-patient basis using clinically measured data.
  
  
  CONCLUSIONS
  We present an overview of the research necessary to bring this approach to fruition. While only a first step, the methodology presented in this article has the potential to increase the predictability of keratorefractive surgery by substantially increasing both the quality and the quantity of the information available to the refractive surgeon preoperatively.
authors.affiliation: Department of Mechanical Engineering, University of California, Davis 95616-5294.
authors.forename: S A
authors.initials: SA
authors.lastname: Velinsky
authors.forename: M R
authors.initials: MR
authors.lastname: Bryant
mesh_terms: D001696:Biomechanical Phenomena; D003198:Computer Simulation; D003315:Cornea / Q000502:physiology; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D055095:Optics and Photonics; D054140:Refractive Surgical Procedures; D013813:Therapy, Computer-Assisted