title: The generation of memory B cells.
abstract: Immunization leads to the generation of antibody forming cells (AFC) and secondary B cells which differ substantially from primary B cells. Based on the function of the progeny of enriched precursor cell populations, naive progenitors of memory B cells have been separated from primary AFC precursors. Precursors of memory cells: (1) require multiple antigenic stimulations to generate antibody responses which are prolonged, of increased magnitude, and generated with rapid kinetics; (2) have the capacity to form germinal centers; (3) accumulate somatic mutations; (4) display repertoire similarities with secondary B cells; and (5) can be stimulated with cross-reactive antigens. The primary AFC precursors responded with characteristic primary responses.
authors.affiliation: Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
authors.forename: P J
authors.initials: PJ
authors.lastname: Linton
authors.forename: N R
authors.initials: NR
authors.lastname: Klinman
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D000941:Antigens / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells / Q000166:cytology; D007108:Immune Tolerance; D007114:Immunization; D007156:Immunologic Memory; D016219:Immunotherapy, Adoptive; D051379:Mice; D008954:Models, Biological; D013154:Spleen / Q000166:cytology / Q000276:immunology
chemical_list: D000941:Antigens