title: Correction of HIV-associated thrombocytopenia with low doses of interferon alfa.
abstract: We have presented a case of HIV-associated thrombocytopenia successfully treated with low dose interferon alfa-2a. Increases in platelet levels were achieved within 1 week without hospitalization or surgery. Further, the patient had no systemic side effects from therapy. Zidovudine alone was ineffective in maintaining noncritical platelet counts. Interferon alfa-2a is a nonimmunosuppressive, nonsurgical therapy that can correct HIV-associated thrombocytopenia without requiring hospitalization.
authors.affiliation: Brown University Program in Medicine, Rhode Island Hospital, Providence 02903.
authors.forename: K P
authors.initials: KP
authors.lastname: Murphy
authors.forename: M D
authors.initials: MD
authors.lastname: Stein
authors.forename: R P
authors.initials: RP
authors.lastname: D'Amico
mesh_terms: D000328:Adult; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D010976:Platelet Count; D011994:Recombinant Proteins; D013921:Thrombocytopenia / Q000150:complications / Q000628:therapy*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins