Hydrogels in endovascular embolization. V. Antitumour agent methotrexate-containing p(HEMA).
The aminohexyl derivative of the copolymer of 2-hydroxyethyl methacrylate and ethylene dimethacrylate (p(HEMA)-Hex) in the form of regular spherical particles was used as a polymeric carrier for chemically sorbed methotrexate (MTX). The effect of the washed p(HEMA)-Hex-MTX carrier on the morphological structure of donor blood, on blood coagulation indicators and on responses of the living tissue surrounding the material which has been in the blood vessel of the rabbit for various periods of time was evaluated. MTX is capable of diffusion for several days from the embolic material.
Horák
D
D
Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague.
Svec
F
F
Adamyan
A
A
Titova
M
M
Skuba
N
N
Voronkova
O
O
Trostenyuk
N
N
Vishnevskii
V
V
Gumargalieva
K
K
D000818:Animals; D001672:Biocompatible Materials; D001769:Blood; D004621:Embolization, Therapeutic; D005263:Femoral Artery / Q000187:drug effects / Q000473:pathology; D005782:Gels; D006487:Hemostasis; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008727:Methotrexate / Q000008:administration & dosage*; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy; D011102:Polyhydroxyethyl Methacrylate; D011817:Rabbits
D001672:Biocompatible Materials; D005782:Gels; D011102:Polyhydroxyethyl Methacrylate; D008727:Methotrexate