title: Studies on the mechanisms of HTLV-I leukemogenesis.
abstract: The factors that regulate low viral expression and long latency after HTLV-I infection are poorly understood. To study the possible mechanisms involved in the regulation of gene expression and cell transformation, we studied whether (1) methylation could play a role in viral transcription, and (2) tax product could favor chromosomal instability. The results indicate that methylation of HTLV-I LTRs blocks their transcriptional activity and that tax protein triggers DNA damage.
authors.affiliation: Institute of Oncology, University of Padova, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Saggioro
authors.forename: F
authors.initials: F
authors.lastname: Majone
authors.forename: M
authors.initials: M
authors.lastname: Forino
authors.forename: L
authors.initials: L
authors.lastname: Turchetto
authors.forename: L
authors.initials: L
authors.lastname: Chieco-Bianchi
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004249:DNA Damage; D016355:Genes, pX / Q000502:physiology*; D015490:HTLV-I Infections / Q000150:complications* / Q000235:genetics; D006801:Humans; D015458:Leukemia, T-Cell / Q000209:etiology* / Q000235:genetics; D008745:Methylation / Q000187:drug effects; D015162:Micronucleus Tests; D010957:Plasmids / Q000235:genetics*; D013755:Tetradecanoylphorbol Acetate; D014158:Transcription, Genetic / Q000235:genetics*; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: D013755:Tetradecanoylphorbol Acetate