title: Aplastic anemia in a male with loss of the Y chromosome.
abstract: We carried out chromosomal analysis of a 33-year-old male who was diagnosed as having aplastic anemia. The patient showed severe pancytopenia, a normal NAP score, hypoplastic marrow and no myelodysplastic changes. 45,XO was found in all bone marrow cells examined, and in 10% of peripheral blood cells examined. To our knowledge, this is the first reported case of male aplastic anemia to show loss of the Y chromosome in all bone marrow cells examined, and this case may suggest a possible mechanism of juvenile onset of aplastic anemia.
authors.affiliation: Department of Internal Medicine, Sasebo Kyosai Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuguchi
authors.forename: H
authors.initials: H
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Fukumoto
authors.forename: S
authors.initials: S
authors.lastname: Okamura
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D000782:Aneuploidy; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D014998:Y Chromosome