Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis.
Fatty acid composition was analysed in the producer of avermectins, Streptomyces avermitilis C-18 grown in chemically defined medium with different nitrogen sources. Significant differences in nitrogen regulation of fatty acid biosynthesis were found in this strain in comparison with other streptomycetes studied so far. This finding could be explained at the level of regulation of branched-chain amino acid metabolism.
Novák
J
J
Institute of Microbiology, Prague, Czechoslovakia.
Hájek
P
P
Rezanka
T
T
Vanĕk
Z
Z
D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D002087:Butyrates / Q000378:metabolism; D003470:Culture Media; D005227:Fatty Acids / Q000032:analysis / Q000096:biosynthesis*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism*
D000597:Amino Acids, Branched-Chain; D002087:Butyrates; D003470:Culture Media; D005227:Fatty Acids; D000644:Quaternary Ammonium Compounds; D007559:Ivermectin; C019264:avermectin; D009584:Nitrogen; C019475:2-methylbutanoic acid