The selective 5-HT2 receptor antagonist amperozide attenuates 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane-induced inhibition of male rat sexual behavior.
This study was aimed at exploring the role of 5-HT2/5-HT1C neurotransmission in male rat sexual behavior. The administration of the 5-HT2/5-HT1C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (1 mg/kg), suppressed sexual activity in most of the animals. The suppressive effect of DOI was antagonized by treatment with amperozide, a selective 5-HT2 receptor antagonist, in doses which did not by themselves affect sexual activity. In addition, several other serotonin antagonists were tested with varying affinity profiles for 5-HT2/5-HT1C receptors, including ketanserin, ritanserin, and mesulergine. All these compounds antagonized the suppressive action of DOI. In contrast, no antagonizing effect was obtained by treatment with (-)-alprenolol, a 5-HT1A antagonist. The present findings suggest that 5-HT2/5-HT1C receptors might be involved in the neural control of male rat sexual behavior, presumably by exerting an inhibitory influence on the behavior.
Klint
T
T
Kabi-Pharmacia Therapeutics AB, Malmö, Sweden.
Dahlgren
I L
IL
Larsson
K
K
D000526:Alprenolol / Q000494:pharmacology; D000662:Amphetamines / Q000037:antagonists & inhibitors*; D000818:Animals; D004873:Ergolines / Q000494:pharmacology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D000662:Amphetamines; D004873:Ergolines; D010879:Piperazines; D012702:Serotonin Antagonists; C049058:amperozide; D016713:Ritanserin; D000526:Alprenolol; D007650:Ketanserin; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine; C031649:mesulergine