title: Antifungal activity of n-tributyltin acetate against some common yam rot fungi.
abstract: The antifungal activity of n-tributyltin acetate (TBTA) was examined in relation to combating yam rot disease. TBTA exhibited a significant effect in vitro and in vivo on four yam rot fungal isolates tested. However, the in vitro toxicity of TBTA was drastically reduced when 2.5% Tween 80 was the solvent instead of 25% acetone, as indicated by the MICs of 156.0 and 5.0 micrograms/ml, respectively.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: P F
authors.initials: PF
authors.lastname: Olurinola
authors.forename: J O
authors.initials: JO
authors.lastname: Ehinmidu
authors.forename: J J
authors.initials: JJ
authors.lastname: Bonire
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001231:Aspergillus flavus / Q000187:drug effects / Q000254:growth & development; D001234:Aspergillus niger / Q000187:drug effects / Q000254:growth & development; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000187:drug effects / Q000254:growth & development; D012233:Rhizopus / Q000187:drug effects / Q000254:growth & development; D014220:Trialkyltin Compounds / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D014220:Trialkyltin Compounds; C011559:tributyltin