[The histochemical formation of the myoadenylate deaminase reaction in human skeletal musculature].
Muscle biopsies from control subjects, patients with neuromuscular diseases and premature infants and neonates were investigated for myoadenylate deaminase activity (MAD) by histochemistry. A histochemically picture of MAD-deficiency is more frequently then the clinically defined MAD-deficiency syndrome with an autosomal recessive pattern of inheritance. The high incidence of the carrier state, secondary MAD-deficiency and connections with other diseases are the causes. An individual predisposition for loading crisis of these patients in a high physical stress situation is probable.
Herrmann
V
V
Landesnervenklinik Brandenburg, Abteilung Neuropathologie.
D000659:AMP Deaminase / Q000172:deficiency / Q000378:metabolism*; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000378:metabolism / Q000473:pathology; D009132:Muscles / Q000033:anatomy & histology / Q000201:enzymology*; D009468:Neuromuscular Diseases / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy
D000659:AMP Deaminase
Zum histochemischen Bild der Myoadenylat-Deaminase-Reaktion (MAD) an humaner Skelettmuskulatur.