title: In situ and invasive vulvar cancer incidence trends (1973 to 1987).
abstract: OBJECTIVE
  The objective of this study was to examine recent trends in the incidence of vulvar cancer.
  
  
  METHODS
  Cases of in situ and invasive squamous cell vulvar cancer were identified from nine Surveillance, Epidemiology, and End Results cancer registries.
  
  
  RESULTS
  The incidence rate of in situ vulvar cancer nearly doubled between 1973 to 1976 and 1985 to 1987, whereas the rate of invasive squamous cell carcinoma remained relatively stable.
  
  
  CONCLUSIONS
  Possible reasons for this discordance include the following: (1) Women affected by the "sexual revolution" are not yet old enough to have invasive vulvar carcinoma; (2) early diagnosis and treatment of in situ carcinoma have mitigated anticipated increases in invasive vulvar carcinoma incidence; (3) in situ and invasive carcinomas of the vulva have different etiologies, with the sexually transmitted human papillomavirus involved in the etiology of in situ carcinoma and other factors involved with most invasive squamous cell carcinoma.
authors.affiliation: Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892.
authors.forename: S R
authors.initials: SR
authors.lastname: Sturgeon
authors.forename: L A
authors.initials: LA
authors.lastname: Brinton
authors.forename: S S
authors.initials: SS
authors.lastname: Devesa
authors.forename: R J
authors.initials: RJ
authors.lastname: Kurman
mesh_terms: D000328:Adult; D044383:Black People; D002278:Carcinoma in Situ / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000453:epidemiology*; D044465:White People