title: Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study.
abstract: To account for the superior prognosis of hyperdiploid, B-progenitor acute lymphoblastic leukemia (ALL), we investigated the influence of trisomy in 1021 children greater than or equal to 1 year old by recursive partitioning analysis. The patients were treated according to a stratified, randomized study testing antimetabolite-based therapies. Trisomies of several individual chromosomes were associated with a better prognosis in a univariate statistical analysis. Of greater importance, trisomy of both chromosomes 4 and 10 identified a subgroup of patients (n = 180) with an extremely favorable 4-year event-free survival (EFS). Combined trisomy of chromosomes 4 and 10 retained its prognostic significance after stratification of patients by DNA index, age, and leukocyte count. Among patients with a DNA index greater than 1.16, patients with trisomies of both chromosomes 4 and 10 had a 4-year EFS of 96.6% (n = 161, SE = 3.8%), whereas patients with neither or only one of these trisomies had a 4-year EFS of 70.4% (n = 73, SE = 11.5%). All 19 patients with a DNA index less than or equal to 1.16 but with trisomies of chromosomes 4 and 10 remain in remission, suggesting that favorable chromosome trisomy dominates in a situation in which the cellular DNA content of less than or equal to 1.16 predicts a less favorable outcome. We conclude that combined trisomy of chromosomes 4 and 10 independently predicts EFS among children with B-progenitor ALL. Patients within the B-progenitor group who have this feature (about 20% of those with clonal abnormalities) are likely to be cured with antimetabolite-based chemotherapy--an approach that should produce few significant late effects.
authors.affiliation: Tomorrows Children's Institute, Hackensack Medical Center, NJ.
authors.forename: M B
authors.initials: MB
authors.lastname: Harris
authors.forename: J J
authors.initials: JJ
authors.lastname: Shuster
authors.forename: A
authors.initials: A
authors.lastname: Carroll
authors.forename: A T
authors.initials: AT
authors.lastname: Look
authors.forename: M J
authors.initials: MJ
authors.lastname: Borowitz
authors.forename: W M
authors.initials: WM
authors.lastname: Crist
authors.forename: R
authors.initials: R
authors.lastname: Nitschke
authors.forename: J
authors.initials: J
authors.lastname: Pullen
authors.forename: C P
authors.initials: CP
authors.lastname: Steuber
authors.forename: V J
authors.initials: VJ
authors.lastname: Land
mesh_terms: D000293:Adolescent; D000328:Adult; D002051:Burkitt Lymphoma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002879:Chromosomes, Human, Pair 10; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D007223:Infant; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011379:Prognosis; D012074:Remission Induction; D014314:Trisomy