title: Vaccine protection of chimpanzees against challenge with HIV-1-infected peripheral blood mononuclear cells.
abstract: Because human immunodeficiency virus (HIV) can be transmitted as cell-free virus or as infected cells (cell-associated virus), vaccines must protect against infection by both viral forms. Vaccine-mediated protection of nonhuman primates against low doses of cell-free HIV-1, HIV-2, or simian immunodeficiency virus (SIV) has been demonstrated. It is now shown that multiple immunizations of chimpanzees with HIV-1 antigens protected against infection with cell-associated virus. Protection can persist for extended periods (one animal had not been exposed to viral antigens for 1 year before challenge). These results show that it is possible to elicit long-lasting protective immunity against cell-associated HIV-1.
authors.affiliation: Department of Microbiology, University of Alabama, Birmingham 35294.
authors.forename: P N
authors.initials: PN
authors.lastname: Fultz
authors.forename: P
authors.initials: P
authors.lastname: Nara
authors.forename: F
authors.initials: F
authors.lastname: Barre-Sinoussi
authors.forename: A
authors.initials: A
authors.lastname: Chaput
authors.forename: M L
authors.initials: ML
authors.lastname: Greenberg
authors.forename: E
authors.initials: E
authors.lastname: Muchmore
authors.forename: M P
authors.initials: MP
authors.lastname: Kieny
authors.forename: M
authors.initials: M
authors.lastname: Girard
mesh_terms: D016915:AIDS Vaccines; D000818:Animals; D015488:HIV Antigens / Q000276:immunology / Q000627:therapeutic use; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology*; D007110:Immunity, Active; D007116:Immunization, Passive; D007156:Immunologic Memory; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008137:Longitudinal Studies; D002679:Pan troglodytes / Q000276:immunology*
chemical_list: D016915:AIDS Vaccines; D015488:HIV Antigens