title: Synergistic interaction of cyclosporin A and verapamil on vincristine and daunorubicin resistance in multidrug-resistant human leukemia cells in vitro.
abstract: We studied the effects of cyclosporin A and verapamil on the modulation of vincristine and daunorubicin resistance in a multidrug-resistant subline of human T-cell acute lymphatic leukemia GM3639. Our results show that cyclosporin A is more effective than verapamil as a modulator of the high degree of primary vincristine resistance and the low degree of daunorubicin cross-resistance expressed by this cell line. Isobologram analysis revealed that the combined modulators act synergistically in correcting both vincristine and daunorubicin resistance.
authors.affiliation: Department of Medicine, College of Medicine, University of California, Irvine 92717.
authors.forename: K
authors.initials: K
authors.lastname: Osann
authors.forename: P
authors.initials: P
authors.lastname: Sweet
authors.forename: L M
authors.initials: LM
authors.lastname: Slater
mesh_terms: D016572:Cyclosporine / Q000494:pharmacology*; D003630:Daunorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D004357:Drug Synergism; D006801:Humans; D007700:Kinetics; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology*
chemical_list: D014750:Vincristine; D016572:Cyclosporine; D014700:Verapamil; D003630:Daunorubicin