title: Meningitis due to penicillin-resistant Streptococcus pneumoniae in patients with chronic graft-versus-host disease.
abstract: Two episodes of meningitis due to penicillin-resistant Streptococcus pneumoniae occurring in two patients with chronic graft-versus-host disease (GVHD) are reported. Both patients were treated with ceftazidime. The first patient died, unresponsive to therapy. The second patient showed clinical improvement, reverting to her baseline mental status. This report draws attention to the fact that in chronic GVHD patients: (1) bacterial prophylaxis does not ensure protection against encapsulated bacteria; (2) rapid microbiological investigation is recommended with any upper respiratory tract infections.
authors.affiliation: Divisione di Ematologia-Laboratorio di Microbiologia Clinica Ospedale, Pescara, Italy.
authors.forename: D
authors.initials: D
authors.lastname: D'Antonio
authors.forename: P
authors.initials: P
authors.lastname: Di Bartolomeo
authors.forename: A
authors.initials: A
authors.lastname: Iacone
authors.forename: P
authors.initials: P
authors.lastname: Olioso
authors.forename: G
authors.initials: G
authors.lastname: Di Girolamo
authors.forename: F
authors.initials: F
authors.lastname: Angrilli
authors.forename: G
authors.initials: G
authors.lastname: Papalinetti
authors.forename: G
authors.initials: G
authors.lastname: Fioritoni
authors.forename: S
authors.initials: S
authors.lastname: Betti
authors.forename: G
authors.initials: G
authors.lastname: Torlontano
mesh_terms: D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000517:prevention & control; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002442:Ceftazidime / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery; D008297:Male; D008586:Meningitis, Pneumococcal / Q000188:drug therapy / Q000209:etiology*; D010403:Penicillin Resistance; D055728:Primary Myelofibrosis / Q000601:surgery
chemical_list: D002442:Ceftazidime