Effect of magnesium lithospermate B in rats with sodium-induced hypertension and renal failure.
To evaluate the antihypertensive effect of magnesium lithospermate B isolated from Salviae miltiorrhizae radix, determinations of blood pressure and urinary excretions of sodium, potassium, prostaglandin E2 (PGE2) and kallikrein, which have been proposed to play an important role in the regulation of blood pressure, were made in rats with sodium-induced hypertension and renal failure. In rats given magnesium lithospermate B, blood pressure was significantly decreased, whereas urinary excretion of electrolytes was significantly increased. Urinary PGE2 excretion following administration of magnesium lithospermate B increased as the dose of the compound was stepped up. The activity of kallikrein in urine was also increased by the treatment. From these results, the blood pressure-lowering action of magnesium lithospermate B may be due in part to enhancement of the kallikrein-prostaglandin system.
Yokozawa
T
T
Department of Applied Biochemistry, Toyama Medical and Pharmaceutical University, Japan.
Lee
T W
TW
Oura
H
H
Nonaka
G
G
Nishioka
I
I
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D015232:Dinoprostone / Q000652:urine; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D007610:Kallikreins / Q000652:urine; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000008:administration & dosage
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D012982:Sodium, Dietary; C061091:lithospermate B; D012964:Sodium; D007610:Kallikreins; D015232:Dinoprostone; D011188:Potassium