[Side effects of clozapine in therapy of psychotic disorders in adolescents. A retrospective clinical study].
A retrospective study was conducted of 53 consecutive inpatients (through 1990) with psychotic disorders. The patients were between 13 and 18 years of age. In all cases this was the first time they had been treated with clozapine. The adverse effects seen under clozapine are discussed. During the use of clozapine assessments were made of liver enzymes, leukocytes, blood pressure and body temperature. There was an increase in liver enzyme values in 37.7% of the patients, leukopenia under 4000/mm3 in 15.1%, an increase in body temperature in 3.8% and bradycardia together with hypotensive dysregulation in 1.9%.
Amminger
G P
GP
Universitätsklinik für Neuropsychiatrie des Kindes- und Jugendalters in Wien.
Resch
F
F
Reimitz
J
J
Friedrich
M H
MH
D000293:Adolescent; D001317:Austria; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D012189:Retrospective Studies; D012307:Risk Factors
D003024:Clozapine
Nebenwirkungen von Clozapin in der Therapie psychotischer Zustandsbilder bei Jugendlichen. Eine retrospektive klinische Studie.