Effects of nonsteroidal anti-inflammatory drugs on endogenous gastrointestinal prostaglandins and therapeutic strategies for prevention and treatment of nonsteroidal anti-inflammatory drug-induced damage.
Although nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for pain relief and treatment of arthritis, they can induce gastric and duodenal ulcers and life-threatening complications. The mechanisms of their anti-inflammatory action and their gastroduodenal toxic effects are related, in part, to inhibition of prostaglandin synthesis. This review article discusses prostaglandins, their functions in the gastrointestinal tract, anti-inflammatory actions of NSAIDs, and mechanisms by which NSAIDs produce gastroduodenal ulcers. Also reviewed are risk factors associated with the development of NSAID-related ulcers and pharmacologic strategies for the prevention and treatment of NSAID-induced ulcers.
Cryer
B
B
Medical Service, Department of Veterans Affairs Medical Center, Dallas, TX 75216.
Feldman
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D011453:Prostaglandins / Q000502:physiology*; D012307:Risk Factors; D013276:Stomach Ulcer / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins