Redressing the balance--the ethics of not entering an eligible patient on a randomised clinical trial.
A double standard exists whereby a treatment given outside a clinical trial is less stringently reviewed than a protocol treatment. We propose a remedy which would require the decision not to participate in an approved, available clinical trial to be subject to the same ethical requirements as trial entry.
Segelov
E
E
Department of Medical Oncology, Royal Prince Alfred Hospital, Camperdown NSW, Australia.
Tattersall
M H
MH
Coates
A S
AS
D001291:Attitude of Health Personnel; D028744:Ethics Committees, Research; D004992:Ethics, Medical; D006801:Humans; D028681:Moral Obligations; D009369:Neoplasms / Q000628:therapy*; D010342:Patient Acceptance of Health Care; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D035842:Research Subjects; D036302:Therapeutic Human Experimentation; D028761:Withholding Treatment