title: The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye.
abstract: The argos gene encodes a protein that is required for viability and that regulates the determination of cells in the Drosophila eye. A developmental analysis of argos mutant eyes indicates that the mystery cells, which are usually nonneuronal, are transformed into extra photoreceptors, and that supernumerary cone cells and pigment cells are also recruited. Clonal analysis indicates that argos acts nonautonomously and can diffuse over the range of several cell diameters. Conceptual translation of the argos gene suggests that it encodes a secreted protein.
authors.affiliation: Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
authors.forename: M
authors.initials: M
authors.lastname: Freeman
authors.forename: C
authors.initials: C
authors.lastname: Klämbt
authors.forename: C S
authors.initials: CS
authors.lastname: Goodman
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002450:Cell Communication; D002999:Clone Cells; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D004627:Embryonic Induction; D005123:Eye / Q000196:embryology*; D015870:Gene Expression; D005796:Genes; D008969:Molecular Sequence Data; D010641:Phenotype; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D015398:Signal Transduction
chemical_list: D012333:RNA, Messenger; D004247:DNA