Effect of serum from patients with endometriosis on the development of mouse embryos.
The effect of serum from patients with endometriosis on the in vitro development of 2-cell mouse embryos was evaluated in the present study. Embryos were cultured for 72 h in 5% serum supplement from patients with endometriosis, infertile patients with no evidence of endometriosis, and Ham's F-10 medium with no serum supplement. Significantly less embryos developed to the blastocyst stage at 72 h in the endometriosis group as compared with the nonendometriosis groups and Ham's F-10 medium (p less than 0.05). These results suggest the presence of one or more serum factors that are toxic to early embryonic development and thus may play a role in the infertility associated with endometriosis, especially with respect to early embryonic loss.
Abu-Musa
A
A
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Takahashi
K
K
Kitao
M
M
D000818:Animals; D001755:Blastocyst; D003470:Culture Media; D005314:Embryonic and Fetal Development; D004715:Endometriosis / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology; D008597:Menstrual Cycle; D051379:Mice; D008813:Mice, Inbred ICR
D003470:Culture Media