Occupational asthma caused by a hardener containing an aliphatic and a cycloaliphatic diamine.
An otherwise healthy 44-yr-old man experienced a serious attack of bronchial obstruction after working with resins and hardeners, releasing fumes of a mixture of an alipathic and a cycloaliphatic diamine hardener. Eight hours after deliberate challenge with the hardener a large increase of airway resistance was found. Seventy-two hours after challenge, eosinophilia in the bronchoalveolar lavage (BAL) fluid together with a decrease of peripheral eosinophils was seen. After cessation of contact with this hardener, no more acute episodes occurred, although maintenance treatment with a topical corticosteroid and a beta 2-agonist remained necessary. A BAL performed 1 yr later showed a normal cell distribution. The results suggest that these aliphatic and cycloaliphatic diamine hardeners may be occupational hazards. Eosinophil inflammation may play a causal role.
Aleva
R M
RM
Department of Allergology, University Hospital, Groningen, The Netherlands.
Aalbers
R
R
Koëter
G H
GH
De Monchy
J G
JG
D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003514:Cyclohexylamines / Q000009:adverse effects*; D003959:Diamines / Q000009:adverse effects*; D004853:Epoxy Resins / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure; D011657:Pulmonary Eosinophilia / Q000139:chemically induced
D003514:Cyclohexylamines; D003959:Diamines; D004853:Epoxy Resins; C052964:isophorone diamine