Pituitary gigantism caused by growth hormone excess from infancy.
A 2 1/4-year-old boy with pituitary gigantism had a large pituitary macroadenoma. Gross tumor removal has prevented further visual losses, but he has had persistent hypersecretion of growth hormone and prolactin. Treatment with somatostatin analog has decreased both hormone secretion and growth velocity.
Gelber
S J
SJ
Division of Pediatric Endocrinology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Heffez
D S
DS
Donohoue
P A
PA
D000236:Adenoma / Q000150:complications* / Q000601:surgery; D002675:Child, Preschool; D005877:Gigantism / Q000188:drug therapy / Q000209:etiology*; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use; D009896:Optic Atrophy / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications* / Q000601:surgery; D011388:Prolactin / Q000378:metabolism; D014786:Vision Disorders / Q000209:etiology
D011388:Prolactin; D013006:Growth Hormone; D015282:Octreotide