title: Effects of temperature and flow rate on regional blood flow and metabolism during cardiopulmonary bypass.
abstract: Eleven dogs were subjected to a 150-minute period of cardiopulmonary bypass that consisted of a high-flow, normothermic phase, a high-flow, hypothermic phase, a low-flow, hypothermic phase, and then a high-flow, rewarming phase. Regional blood flow and oxygen consumption to the brain, intestines, kidney, and hind limb were determined at baseline and at 10-minute intervals during cardiopulmonary bypass. Blood flow to the carotid artery, superior mesenteric artery, and renal artery declined significantly with hypothermic cardiopulmonary bypass whereas blood flow to the femoral artery increased significantly. Although total body oxygen consumption returned to baseline values at the end of the rewarming phase, oxygen consumption for these regions differed somewhat from their baseline values. We conclude that blood flow during hypothermic cardiopulmonary bypass is shunted to skeletal muscle, particularly with high pump flows. Additionally, the return of total body oxygen consumption to baseline after rewarming is not necessarily reflected at the regional level.
authors.affiliation: Division of Cardiothoracic Surgery, New York Hospital-Cornell Medical Center, New York 10021.
authors.forename: W D
authors.initials: WD
authors.lastname: Lazenby
authors.forename: W
authors.initials: W
authors.lastname: Ko
authors.forename: J A
authors.initials: JA
authors.lastname: Zelano
authors.forename: N
authors.initials: N
authors.lastname: Lebowitz
authors.forename: Y T
authors.initials: YT
authors.lastname: Shin
authors.forename: O W
authors.initials: OW
authors.lastname: Isom
authors.forename: K H
authors.initials: KH
authors.lastname: Krieger
mesh_terms: D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000378:metabolism; D002315:Cardiopulmonary Bypass; D002339:Carotid Arteries / Q000502:physiology; D004285:Dogs; D005260:Female; D005263:Femoral Artery / Q000502:physiology; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D008638:Mesenteric Arteries / Q000502:physiology; D009132:Muscles / Q000378:metabolism; D010101:Oxygen Consumption; D012039:Regional Blood Flow; D012077:Renal Artery / Q000502:physiology
chemical_list: D007773:Lactates; D019344:Lactic Acid