title: Epidural pethidine and bupivacaine in labour.
abstract: A double-blind randomised study was performed to assess the value of the addition of pethidine 50 mg to the initial dose of bupivacaine given for epidural analgesia in labour. Forty-nine patients received either 1 ml of saline (n = 24), or 50 mg of pethidine (n = 25), added to 9 ml of 0.25% bupivacaine as an initial injection for intrapartum epidural analgesia. There was a significant increase in the mean duration of analgesia in the pethidine group. However, pethidine did not increase the speed of onset of analgesia, or improve the quality of analgesia.
authors.affiliation: University Hospital of Wales, Heath Park, Cardiff.
authors.forename: N D
authors.initials: ND
authors.lastname: Edwards
authors.forename: M
authors.initials: M
authors.lastname: Hartley
authors.forename: P
authors.initials: P
authors.lastname: Clyburn
authors.forename: M
authors.initials: M
authors.lastname: Harmer
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural; D016362:Analgesia, Obstetrical; D002045:Bupivacaine; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008614:Meperidine; D007744:Obstetric Labor Complications / Q000517:prevention & control; D011247:Pregnancy
chemical_list: D008614:Meperidine; D002045:Bupivacaine