A case of developmental glaucoma presenting with abdominal colic and subnormal intraocular pressure.
A healthy baby boy presented with abdominal colic. He was subsequently noted to have enlarged, edematous corneas. A clinical diagnosis of developmental glaucoma was made despite ocular hypotony. Trabeculectomies were designed to include peripheral cornea. This served as a biopsy to confirm the diagnosis and as a surgical treatment for the condition. Morphological examination of the outflow system revealed findings compatible with a diagnosis of developmental glaucoma: a hypoplastic trabecular meshwork which contained an abundance of abnormal collagenous tissue in the extracellular spaces and the presence of endothelial cells overlying a continuous collagenous membrane. In the iris stroma there were numerous abnormal blood vessels, with a paucity of mural contractile cells.
Talbot
E M
EM
Royal Hospital for Sick Children, Yorkhill, Glasgow, Scotland, UK.
Pitts
J F
JF
Dudgeon
J
J
Lee
W R
WR
D003085:Colic / Q000150:complications*; D015715:Corneal Edema / Q000175:diagnosis; D005901:Glaucoma / Q000150:complications* / Q000601:surgery; D006801:Humans; D007223:Infant; D007429:Intraocular Pressure; D007498:Iris / Q000473:pathology; D008297:Male; D014129:Trabecular Meshwork / Q000473:pathology; D014130:Trabeculectomy