title: "Floating" labyrinth. Pathophysiology and treatment of perilymph fistula.
abstract: Collapse of the membranous labyrinth of the pars superior is a morphological change observed in 50% of animals with experimentally produced perilymph fistula, although the extent and degree of the collapse may vary greatly. The moderately collapsed membranous labyrinth may drift with CSF and/or perilymph pressure changes and this may stimulate sensory cells of the utricle and/or semicircular canals if the sensory cells are intact and the collapsed wall is in contact with the otolithic membrane and/or cupula. This condition is termed "floating" labyrinth. Caloric irregularity is often observed in electronystagmograms recorded from animals with experimental perilymph fistula. This is also observed in patients with perilymph fistula. Partial destruction of the vestibular organs using argon laser was performed in a patient with perilymph fistula who was incapacitated because of persistent positional vertigo after closure of the oval window fistula. Irradiation of the argon laser beam was directed to the macula utriculi, utriculoampullary nerve and singular nerve. The hearing of the patient was maintained, and vertigo disappeared after laser labyrinthectomy.
authors.affiliation: Department of Otolaryngology, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: M
authors.initials: M
authors.lastname: Hara
authors.forename: Y H
authors.initials: YH
authors.lastname: Young
mesh_terms: D001301:Audiometry, Pure-Tone; D002150:Caloric Tests; D007758:Ear, Inner / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005402:Fistula / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D007759:Labyrinth Diseases / Q000503:physiopathology* / Q000601:surgery; D053685:Laser Therapy; D008575:Meniere Disease / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D010498:Perilymph / Q000502:physiology*