title: General perspectives, pathogenesis, pathophysiology, and skeletal dysfunction.
abstract: A better understanding of the pathogenesis and pathophysiology of the metastatic process is leading to improvements in diagnosis and treatment. Evaluation of specific areas of disorder of skeletal function, including hematopoiesis, mineral metabolism, and structural support, is important. Continued developments are necessary to minimize or prevent effects on the skeleton related to the metastatic process.
authors.affiliation: Department of Orthopedics, Mayo Clinic, Rochester, Minn. 55905.
authors.forename: F J
authors.initials: FJ
authors.lastname: Frassica
authors.forename: F H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D001696:Biomechanical Phenomena; D001859:Bone Neoplasms / Q000175:diagnosis / Q000503:physiopathology* / Q000556:secondary; D001842:Bone and Bones / Q000378:metabolism; D003937:Diagnosis, Differential; D006410:Hematopoiesis; D006801:Humans; D008903:Minerals / Q000378:metabolism; D009362:Neoplasm Metastasis / Q000503:physiopathology
chemical_list: D008903:Minerals