[Manganese-DPDP in the MR tomography of malignant liver tumors. The initial results with a new hepatobiliary contrast agent].
The new hepatobiliary contrast agent Mangan-DPDP, unlike extracellular Gd-DTPA, leads to a constant increase in signal intensity of normal liver tissue in MR imaging of the liver which lasts at least for 30 minutes. In 19 patients with malignant liver tumors there was no difference in the contrast between tumor and liver when using a dose of 5 or 10 mumol/kg. Contrast enhanced T1-w SE- and T1-w GE sequences show a significant increase in tumor/liver contrast compared with T1-weighted unenhanced sequences. This increase was also significant when compared with T2-w SE sequences. In 16% additional focal lesions were detected on the enhanced scan.
Steudel
A
A
Radiologische Klinik, Rheinische Friedrich-Wilhelms-Universität Bonn.
Layer
G
G
Kraheck
H
H
Hartlapp
J
J
Reiser
M
M
D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage; D004341:Drug Evaluation; D004492:Edetic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007262:Infusions, Intravenous; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008345:Manganese / Q000008:administration & dosage; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012680:Sensitivity and Specificity
D003287:Contrast Media; D008345:Manganese; D011732:Pyridoxal Phosphate; D004492:Edetic Acid; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
Mangan-DPDP in der MR-Tomographie maligner Lebertumoren. Erste Ergebnisse mit einem neuen hepatobiliären Kontrastmittel.