Are there salvage routes within the general secretory pathway in yeast?
It is generally accepted that both extracellular protein secretion and plasma membrane expansion in yeast occur basically as in higher eukaryotic cells. In addition to the constitutive (default) secretory pathway, some specialized mammalian cells possess a regulated route which at present has not been detected in yeast. However, there is a body of experimental results suggesting that under certain circumstances export of integral plasma membrane and exocellular proteins may take place through alternative (salvage) pathways. The existence of these latter routes would enable the yeast cell to adapt more efficiently to distinct or adverse conditions requiring the secretion of discrete amounts of specific sets of proteins.
Gozalbo
D
D
Sección de Microbiología, Facultad de Farmacia, Universitat de València, Spain.
Martínez
J P
JP
Sentandreu
R
R
D002352:Carrier Proteins / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism*; D005800:Genes, Fungal; D006023:Glycoproteins / Q000096:biosynthesis / Q000378:metabolism; D006056:Golgi Apparatus / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D015388:Organelles / Q000502:physiology; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D002352:Carrier Proteins; D005656:Fungal Proteins; D006023:Glycoproteins; D008565:Membrane Proteins