title: Trace elements and the electroencephalogram during long-term lithium treatment.
abstract: Endogenous bromine has been found to be raised during lithium treatment, and it has been suggested that it may augment the therapeutic effect of lithium. Our findings in a study of 12 patients and 12 controls support this contention. Electroencephalographic effects of bromine, vanadium and aluminium were studied--higher bromine and vanadium levels were associated with irregular cortical activity. Electroencephalographic abnormalities were associated with more side-effects of lithium.
authors.affiliation: University of Sheffield, Royal Hallamshire Hospital.
authors.forename: N S
authors.initials: NS
authors.lastname: Harvey
authors.forename: J
authors.initials: J
authors.lastname: Jarratt
authors.forename: N I
authors.initials: NI
authors.lastname: Ward
mesh_terms: D000535:Aluminum / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D001966:Bromine / Q000097:blood; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D014131:Trace Elements / Q000097:blood*; D014639:Vanadium / Q000097:blood
chemical_list: D014131:Trace Elements; D014639:Vanadium; D008094:Lithium; D000535:Aluminum; D001966:Bromine