Estimation of the male and female mutation rates in Duchenne muscular dystrophy (DMD).
We present the results of an international collaborative study aimed at estimating the ratio of male to female mutation rates in Duchenne muscular dystrophy based on the method of C. Müller and T. Grimm. With a sample size of 295, this ratio is found to be very close to 1, thus giving evidence for equal mutation rates in males and females in Duchenne muscular dystrophy.
Müller
B
B
Abteilung für pädiatrische Genetik und pränatale Diagnostik, Kinderpoliklinik der Universität, München, Federal Republic of Germany.
Dechant
C
C
Meng
G
G
Liechti-Gallati
S
S
Doherty
R A
RA
Hejtmancik
J F
JF
Bakker
E
E
Read
A P
AP
Jeanpierre
M
M
Fischbeck
K H
KH
D015139:Blotting, Southern; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D009136:Muscular Dystrophies / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D012737:Sex Factors; D014481:United States