Pulmonary and haemodynamic effects of extracorporeal circulation in the cat and the beneficial effects of prostacyclin.
Side-effects of a veno-venous extracorporeal system and possible beneficial effects of prostacyclin (epoprostenol) are analyzed on the cat. Three groups were studied; one control group without extracorporeal circulation and two groups with an extracorporeal flow of 10-12 ml/kg/min, one of which was given prostacyclin (70-110 ng/kg/min). The extracorporeal circulation triggered a decrease in arterial saturation (from 99 to 91%) and carbon dioxide elimination (increase in arterial to end-tidal PCO2 by about 1 kpa) a metabolic acidosis (pH approximately 7.20), a platelet consumption (approximately 50%) and shortened survival time, side-effects reduced by prostacyclin. Further, there was a marked increase in haemoglobin concentration indicating hypovolemia via capillary fluid filtration. None of these side-effects were seen in the control group. Extracorporeal circulation as a trigger for pulmonary dysfunction and for impaired tissue nutrition with possible beneficial effects of prostacyclin is discussed, and also form a clinical point of view (i.e. extracorporeal lung assistance, ECLA), on the basis of the results.
Jahr
J
J
Department of Physiology and Biophysics, University of Lund, Sweden.
Grände
P O
PO
D000818:Animals; D001784:Blood Gas Analysis; D002415:Cats; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D011464:Epoprostenol / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects; D008171:Lung Diseases / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D010100:Oxygen / Q000097:blood; D010976:Platelet Count / Q000187:drug effects; D015996:Survival Rate
D006454:Hemoglobins; D011464:Epoprostenol; D010100:Oxygen