Bioavailability of two ibuprofen oral paste formulations in fed or nonfed ponies.
The bioavailability and pharmacokinetics of ibuprofen, a nonsteroidal antiinflammatory drug, was studied in healthy Shetland ponies. Ibuprofen was administered IV, as a suspension, and as a solid solution oral paste to ponies from which food was withheld. The suspension paste was also administered to ponies that received hay and water ad libitum. Both formulations had an absolute bioavailability of about 80%. Bioavailability was not influenced by feeding.
Vandenbossche
G M
GM
Laboratory of Pharmaceutical Technology, Gent, Belgium.
Bouckaert
S
S
De Muynck
C
C
Mommens
G
G
Van Zeveren
A
A
Remon
J P
JP
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004435:Eating / Q000502:physiology; D005260:Female; D006207:Half-Life; D006736:Horses / Q000378:metabolism*; D007052:Ibuprofen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D009824:Ointments; D014018:Tissue Distribution
D009824:Ointments; D007052:Ibuprofen