[The radiation modification of the sugar fragment in DNA: the formation of breaks, a change in polymer conformation and the transfer of the damage to the base].
Comparative analysis of the author's own data and data reported in the literature on the nature of the intermediate and end molecular products of radiolysis of DNA, its precursors and substances stimulating certain DNA fragments, allows to attribute the formation of breaks and alkaline-labile sites in DNA strands and changes in the polymer conformation, to the formation and transformations of some types of primary radicals of the sugar fragment. In order to explain certain effects induced by irradiation of DNA and its precursors (a balance of basic products of radiation destruction of DNA and ESR data concerning low temperature radiolysis of bases, nucleotides and nucleosides) the author proposes a model of the transfer of a damage (free valence) from 2-deoxyribosyl to a base within one nucleotide.
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D001482:Base Composition / Q000528:radiation effects; D002236:Carbohydrate Conformation / Q000528:radiation effects; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000528:radiation effects*; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004249:DNA Damage; D066298:In Vitro Techniques; D009690:Nucleic Acid Conformation / Q000528:radiation effects*; D012996:Solutions
D002241:Carbohydrates; D012996:Solutions; D004247:DNA
Radiatsionnaia modifikatsiia sakharnogo fragmenta v DNK: obrazovanie razryvov, izmenenie konformatsii polimera, peredacha povrezhdeniia na osnovanie.