Aminoglutethimide in malignant melanoma. A phase II study.
The role of steroid hormones has been suggested in the growth of malignant melanoma, and since aromatase activity has been found in melanoma tissue, we carried out a phase II study of aminoglutethimide, an aromatase inhibitor in malignant melanoma patients. Fifteen heavily pretreated patients entered the study. No response was observed--the treatment was well tolerated. We concluded that aminoglutethimide is very unlikely to be useful in melanoma patients.
Block
S
S
Centre Oscar Lambret, BP 307-59020 Lille, France.
Bonneterre
J
J
Adenis
A
A
Pion
J M
JM
Demaille
A
A
D000328:Adult; D000368:Aged; D000616:Aminoglutethimide / Q000627:therapeutic use*; D047072:Aromatase Inhibitors; D004341:Drug Evaluation; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged
D047072:Aromatase Inhibitors; D000616:Aminoglutethimide