[Prevalence of lipid disorders and their course after blood pressure control in essential arterial hypertension].
BACKGROUND
Arterial hypertension and hyperlipidemia are the principal factors of cardiovascular risk with an association which appears to obey common pathogenic bonds. In the present study the initial prevalence of hypercholesterolemia and hypertriglyceridemia was determined in a sample of essential hypertensives and the long term effect of different antihypertensive treatments on lipid metabolism has been analyzed.


METHODS
Total cholesterol, its LDL and HDL fractions and plasmatic triglycerides were determined in a sample of 158 hypertensive patients prior to the initiation of antihypertensive treatment and following one year of normotension.


RESULTS
The initial prevalence of lipid disturbances was of 47% (isolated hypercholesterolemia 17%, isolated hypertriglyceridemia 14% and mixed anomalies 16%). After one year of tension control the initial prevalence was not modified. In the patients controlled with a low sodium diet a decrease in total cholesterol and an increase in cholesterol-HDL were observed in those treated with atenolol, and a decrease in cholesterol-LDL was seen in those receiving captopril. The group treated with nifedipin presented no significant variations of the lipid profile.


CONCLUSIONS
The prevalence of lipid disturbances is greater among the hypertensive patient than in the general population. The rational treatment of a hypertensive patient must not only regard blood pressure figures but also control the other risk factors since the drugs commonly used in the treatment of arterial hypertension generally demonstrate a neutral effect on lipid metabolism.
Sánchez
M
M
Servicio de Medicina Interna General, Hospital Clínic i Provincial, Facultad de Medicina, Universidad de Barcelona.
Sobrino
J
J
Coca
A
A
de la Sierra
A
A
Lluch
M M
MM
Aguilera
M T
MT
Picado
M J
MJ
Urbano-Márquez
A
A
D005500:Follow-Up Studies; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000453:epidemiology*; D006973:Hypertension / Q000150:complications / Q000628:therapy*; D015228:Hypertriglyceridemia / Q000150:complications / Q000453:epidemiology*; D015995:Prevalence
Prevalencia de los trastornos lipídicos y su evolución tras el control tensional en la hipertensión arterial esencial.