title: Antioxidant-influenced alterations in glutathione reductase activity in different age groups of male mice.
abstract: The glutathione reductase activity was estimated in brain and liver of male mice of different age groups fed on butylated hydroxy anisole (BHA), propyl gallate (PG) and alpha-tocopherol (TP). A significant increase in glutathione reductase activity was observed with TP during all the phases (pre-reproductive, reproductive and post-reproductive). Antioxidants enhanced the enzyme activity in both the tissues with the exception of BHA in brain during reproductive and PG in liver during pre-reproductive phases respectively. The enhanced reducing potential of the cell in terms of added bioconversion of GSSG to GSH may account for increase in longevity on antioxidant treatment.
authors.affiliation: Department of Molecular Biology, Guru Nanak Dev University, Amritsar, India.
authors.forename: S C
authors.initials: SC
authors.lastname: Khanna
authors.forename: S K
authors.initials: SK
authors.lastname: Garg
authors.forename: S P
authors.initials: SP
authors.lastname: Sharma
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D005980:Glutathione Reductase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D011435:Propyl Gallate / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D002083:Butylated Hydroxyanisole; D011435:Propyl Gallate; D005980:Glutathione Reductase