title: The influence of hepatic artery ligation and of vasopressin on liver tumour blood flow in rats.
abstract: The blood flow in an experimental adenocarcinoma in the rat liver was determined with the 133Xe-washout technique before and after hepatic artery ligation (HAL). There was an initial reduction of the washout of 50%. This was further reduced after 1 day by 50%, which was maintained for 7 days. Seven days after HAL or sham procedures the 133Xe-washout was of similar magnitude in the liver tumours, although after the sham procedure the tumours were larger (3.4 g vs. 1.5 g). The estimated tumour blood flow was then approximately 0.04 ml x min-1 x g-1. The influence on normal liver parenchyma of HAL was a reduction at 30 minutes, which was maintained for 7 days. Postacton--a synthetic vasopressin--did not influence the 133Xe-washout in normal liver parenchyma in non-tumour, as well as in tumour-bearing animals. There was no influence of Postacton on the 133Xe-washout in the liver tumours. Thirty minutes after HAL Postacton gave a reduction of blood flow in normal liver parenchyma of tumour-bearing animals, which is thus only from the portal vein. In tumours Postacton did not significantly reduce the tumour blood flow immediately after HAL.
authors.affiliation: Department of Surgery, Sahlgrenska Hospital, University of Göteborg, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Naredi
authors.forename: P
authors.initials: P
authors.lastname: Lindnér
authors.forename: S B
authors.initials: SB
authors.lastname: Holmberg
authors.forename: R
authors.initials: R
authors.lastname: Söderberg
authors.forename: G
authors.initials: G
authors.lastname: Carlsson
authors.forename: B
authors.initials: B
authors.lastname: Gustavsson
authors.forename: L
authors.initials: L
authors.lastname: Jacobsson
authors.forename: L
authors.initials: L
authors.lastname: Hafström
mesh_terms: D000818:Animals; D005260:Female; D006499:Hepatic Artery / Q000000981:diagnostic imaging; D008026:Ligation; D008102:Liver Circulation / Q000187:drug effects; D008113:Liver Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D014667:Vasopressins