[Detection of human papillomaviruses (HPV) in laryngeal papilloma. An in situ hybridization study].
Together 35 papillomas of the larynx (8 juveniles, 27 adults) were studied for the presence of HPV-DNA by means of nucleic acid hybridization. The hybridization procedure was carried out "in situ" with biotinylated probes of HPV 6/11 and 16/18 under stringent conditions. The results are shown in Table 1. In all juvenile papillomas we detected HPV 6/11, but we did not find positive signals after hybridization with HPV 16/18, 25 (92.6%) of the examinated adult papillomas were HPV 6/11 positive. The detection procedure of HPV 16/18 was positive twice (11.8%). The results of our studies support the hypothesis of HPV 6/11 in development of larynxpapillomas.
Arndt
O
O
HNO-Klinik, Marienkrankenhaus Hamburg.
Zeise
K
K
Bauer
I
I
Brock
J
J
D000328:Adult; D001706:Biopsy; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology*; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010212:Papilloma / Q000473:pathology*; D014412:Tumor Virus Infections / Q000473:pathology*
D015344:DNA Probes, HPV
Der Nachweis humaner Papillomviren (HPV) in Larynxpapillomen. Eine In-situ-Hybridisierungsstudie.