Viral expressions in Reed-Sternberg cells.
In the murine system natural hybridoma formation was observed first in 1968-9. In the #620 to 818 system a mouse leukemia virus-(MLV-) producer diploid lymphoma cell fused with an immune plasma cell. The tetraploid fusion product cells grew in suspension cultures and as ascites tumors in mice and continued the production of MLV particles and MLV-neutralizing antibodies. Analogy between the #620 to 818 system and the origin of RS cells is proposed. Indirect evidence suggests retroviral infection of the mononuclear HD cell which presumably is an interdigitating reticulum (IR) cell. Reactive B and T cells interact in an abnormal manner and fuse with the retrovirally infected IR cell. The fusion product cells display hyperdiploidy and a disarray of markers as IR markers are lost due to dedifferentiation (and regained upon differentiation induction) and B and/or T cell markers are gained. Conventional theories for the origin of RS cells fail to explain the great heterogeneity of their markers. Derivation of RS cells from IR cells and B and/or T lymphocytes as natural hybridomas offers plausible explanation for all the features of RS cells.
Sinkovics
J G
JG
Cancer Institute, St. Joseph's Hospital, Tampa, Florida 33677.
Gonzalez
F
F
Gyorkey
F
F
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis*; D006689:Hodgkin Disease / Q000382:microbiology / Q000473:pathology; D006825:Hybridomas / Q000473:pathology; D051379:Mice; D016253:Microscopy, Immunoelectron; D009500:Neutralization Tests; D016539:Reed-Sternberg Cells / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D013155:Spleen Focus-Forming Viruses / Q000276:immunology / Q000302:isolation & purification*
D000914:Antibodies, Viral