Early and late B-cell development in the mouse.
A common principle in B-cell development is the stringent selection of cells expressing appropriate antibody V regions as surface receptors. Cells failing to do so appear destined to rapid death. These life-death decisions are mediated by signals whose nature is not yet understood but whose generation involves immunoglobulin receptor complexes on B cells and B-cell progenitors.
Rajewsky
K
K
Institute for Genetics, University of Cologne, Germany.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016923:Cell Death / Q000276:immunology; D002454:Cell Differentiation; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000276:immunology
D011947:Receptors, Antigen, B-Cell