title: [Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats].
abstract: The effects of silybin (Sil) on myocardial infarction size and ischemia- and reperfusion-induced arrhythmias were studied in anesthetized open chest Sprague-Dawley rats. It was found that pretreatment with Sil 20, 50, and 80 mg.kg-1 iv reduced significantly infarct size by 34.7%, 35.0%, and 50.6% respectively at 4 h after ligation. Sil prevented ischemic arrhythmia only at the dose of 80 mg.kg-1. In reperfusion experiment, pretreatment with Sil 20 mg.kg-1 decreased significantly reperfusion-induced arrhythmia.
authors.affiliation: Department of Cardiology, Changhai Hospital, Shanghai, China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: D F
authors.initials: DF
authors.lastname: Su
authors.forename: T H
authors.initials: TH
authors.lastname: Zhang
authors.forename: H J
authors.initials: HJ
authors.lastname: Ding
authors.forename: Y C
authors.initials: YC
authors.lastname: Yang
authors.forename: S C
authors.initials: SC
authors.lastname: Chen
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000150:complications; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000627:therapeutic use*
chemical_list: D012838:Silymarin