title: The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex.
abstract: The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interfering with CTL generation and localization in the tumor mass.
authors.affiliation: Institute of Oncology, University of Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Rosato
authors.forename: V
authors.initials: V
authors.lastname: Bronte
authors.forename: F
authors.initials: F
authors.lastname: Pollis
authors.forename: S
authors.initials: S
authors.lastname: Mandruzzato
authors.forename: A
authors.initials: A
authors.lastname: Zambon
authors.forename: P
authors.initials: P
authors.lastname: Zanovello
authors.forename: D
authors.initials: D
authors.lastname: Collavo
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D051379:Mice; D008979:Moloney murine leukemia virus; D008980:Moloney murine sarcoma virus; D012513:Sarcoma, Experimental / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D016169:Lymphocyte Function-Associated Antigen-1