Inhibition of aeroallergen-induced bronchial eosinophilia by azelastine in guinea pigs.
The ability of azelastine to influence allergic bronchial eosinophil infiltration in guinea pigs was studied. Aeroallergen challenge of actively sensitized guinea pigs produces eosinophil infiltration in bronchoalveolar lavage fluid collected 20-24 h after aeroallergen exposure. Azelastine and methylprednisolone, administered orally 2 h before challenge, inhibited eosinophilic infiltration yielding the ED50s of 1.55 and 4.48 mg/kg, respectively. WEB-2086, a platelet-activating factor antagonist (3 mg/kg), and theophylline, a phosphodiesterase inhibitor (30 mg/kg), also suppressed allergic bronchial infiltration of eosinophils by 44%. The data obtained in this study demonstrate that azelastine exerts direct bronchial anti-inflammatory activity in guinea pigs.
Chand
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Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, N.J. 08512.
Nolan
K
K
Diamantis
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W
Sofia
R D
RD
D000284:Administration, Oral; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology; D010793:Phthalazines / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011657:Pulmonary Eosinophilia / Q000139:chemically induced / Q000188:drug therapy*; D013806:Theophylline / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology
D001381:Azepines; D001993:Bronchodilator Agents; D010793:Phthalazines; D010972:Platelet Activating Factor; D014230:Triazoles; C052518:WEB 2086; D013806:Theophylline; D008775:Methylprednisolone; C020976:azelastine