Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate.
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmacokinetic profile and thermogenic effect during a short-time infusion (5 h at 10 g/h) in 7 male volunteers. Sebacate in serum and urine was measured by high-performance liquid chromatography. A single-compartment model with two linear elimination routes was fitted. Metabolic measurements (VO2, VCO2, respiratory quotient, metabolic rate) were continuously performed for 8 h (5 h during and 3 h after the infusion) by a canopy indirect calorimeter. The apparent volume of distribution of sebacate was 8.39 +/- 0.69 liters, and the plasma fractional removal rate constant was 0.0086 +/- 0.00077 min-1. The average half-life and plasma clearance were 80.6 min and 72 ml/min, respectively. The increase in metabolic rate, the decrease in respiratory quotient and the changes in ketone body, glucagon and insulin levels during the infusion were not significant. 24-hour catecholamine excretion was within normal limits. Calories administered by sebacate seem to be available for utilization without relevant metabolic side effects.
Greco
A V
AV
Istituto di Clinica Medica, CNR Centro Studio Fisiopathologia Shock, Università Cattolica del Sacro Cuore, Roma, Italia.
Mingrone
G
G
Raguso
C
C
Tataranni
A
A
Finotti
E
E
Tacchino
R M
RM
Capristo
E
E
De Gaetano
A
A
Castagneto
M
M
D000328:Adult; D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D003652:Decanoic Acids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003998:Dicarboxylic Acids / Q000097:blood / Q000652:urine; D004734:Energy Metabolism; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009765:Obesity / Q000378:metabolism
D003652:Decanoic Acids; D003998:Dicarboxylic Acids; C011107:sebacic acid