[Preliminary studies of the relationship between micronucleus formation and cell cycle. IV. Micronucleus formation induced by chemical mutagens at G0, G1, S and G2 phases of human lymphocytes].
In this paper the authors studied quantitatively the micronucleus formation at various phases of interphase in human lymphocytes induced by chemical mutagens by means of control of cell culture intervals, autoradiography and block of metaphase cells etc. The results show that mutagenic anti-tumor drugs: bimolane (treatment in vitro) and thio-tepa etc. (treatment in vivo) can induce micronucleus formation at various phases of interphase in lymphocytes. The frequency of micronucleus (MNF) induced at G1 phase is significantly higher than that at G0 and G2 phase. The MNF at S phase of cells is obviously lower than at G1. This result suggests that most of the micronucleated cells at G1 phase do not enter S phase and micronucleus rarely form at S phase of cells.
Xue
K
K
Cancer Institute of Jiangsu Province, Nanjing.
Ma
G
G
Wu
J
J
Shan
Z
Z
D000293:Adolescent; D000328:Adult; D002453:Cell Cycle / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000473:pathology; D005260:Female; D016193:G1 Phase / Q000187:drug effects; D016195:G2 Phase / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009153:Mutagens / Q000009:adverse effects*; D016192:Resting Phase, Cell Cycle / Q000187:drug effects; D016196:S Phase / Q000187:drug effects
D009153:Mutagens