[Glucose determination as prognosis index of intra-amniotic infection].
Intraamniotic infection is a frequent problem in Obstetrics, and is related with an important maternal and fetal impact, being important pre-term delivery and premature rupture of membranes. The "golden" test for this entity is bacteriological culture. Its use is limited in function of time (more than two days) and disponibility. The rapid diagnosis of infection in vital to start antimicrobial management and evaluation of uterine evacuation. Low concentrations of glucose (G) have been used as prognostic of infection in different biological compartments. The objective of this study is to evaluate the usefulness of G as prognostic index of intraamniotic infection (PIIAI) as compared with Gram tincture (GT) and bacteriological culture. Sixty four patients were included. Group I (n = 33) with infection, and group II (n = 31) without infection. Average of G for group I was 19.96 +/- 07.61 ES and 114.46 +/- 20.09 ES for the group II, with p less than 0.001. The sensitivity (S), specificity (Sp), positive predictive value (+PV) and negative (-PV) for a concentration of G in amniotic fluid less than 15 mg/dl was 72, 77, 77 and 72% respectively. The S, Sp +PV and -PV for G minor than 10 mg/dl was 69, 87, 85 and 73%. Gram tinction had a S, Sp +PV and -PV of 57, 83, 79, 65%. If both determinations are put together (G and GT), one sees and S of 88%, Sp 77% +PV 80% and -PV 85%.(ABSTRACT TRUNCATED AT 250 WORDS)
Bustos Lopez
H H
HH
Departamento de Bioquímica e Infectología e Inmunología Perinatal, Instituto Nacional de Perinatología, México, D.F.
Luis Arredondo
J
J
Villanueva Diaz
C
C
Soto Martinez
J
J
Arias Martinez
J
J
Vadillo Ortega
F
F
D000650:Amnion; D000653:Amniotic Fluid / Q000737:chemistry*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005947:Glucose / Q000032:analysis*; D006801:Humans; D007239:Infections / Q000175:diagnosis*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D011379:Prognosis; D015203:Reproducibility of Results
D005947:Glucose
Determinación de glucosa como indice pronóstico de infección intraamniótica.