Anticoagulant effects of sulphonated polyurethanes.
Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma.
Silver
J H
JH
Department of Chemical Engineering, University of Wisconsin-Madison 53706.
Hart
A P
AP
Williams
E C
EC
Cooper
S L
SL
Charef
S
S
Labarre
D
D
Jozefowicz
M
M
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001672:Biocompatible Materials; D001777:Blood Coagulation / Q000187:drug effects; D004285:Dogs; D005337:Fibrin / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D011140:Polyurethanes / Q000737:chemistry / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000494:pharmacology; D013917:Thrombin / Q000037:antagonists & inhibitors
D000925:Anticoagulants; D001672:Biocompatible Materials; D011140:Polyurethanes; D013451:Sulfonic Acids; D005337:Fibrin; D013917:Thrombin