Effects of m-nisoldipine and nisoldipine on electric activity of human atrial tissue.
Using intracellular microelectrode technique and microcomputer analyzing system, the effects of m-nisoldipine (m-Nis) and nisoldipine (Nis) on spontaneous electric activity of human atrial tissue were studied. APA and Vmax were remarkably decreased by m-Nis (0.25 and 1.25 mumol.L-1) and Nis (0.25 mumol.L-1). RPF was also greatly decreased as a result of inhibition in VDD. The inhibitory effects of m-Nis on transmembrane potentials were less than those of Nis at equal concentration (0.25 mumol.L-1). Neither MDP nor APD90 was affected by m-Nis and Nis.
Yang
X P
XP
Department of Physiology, Institute of Basic Medicine, Hebei Medical College, Shijiazhuang, China.
An
R H
RH
He
R R
RR
Xie
Y K
YK
Liu
S X
SX
Liu
S
S
D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D016275:Atrial Function; D002648:Child; D002675:Child, Preschool; D006801:Humans; D066298:In Vitro Techniques; D007536:Isomerism; D008839:Microelectrodes; D015737:Nisoldipine / Q000494:pharmacology*
D015737:Nisoldipine