Influence of substituting B2O3 for CaF2 on the bonding behaviour to bone of glass-ceramics containing apatite and wollastonite.
Glass-ceramics containing crystalline oxy-fluoroapatite (Ca10(PO4)6(O,F2)) and wollastonite (CaSiO3) (designated AWGC) are reported to have a fairly high mechanical strength as well as the capability of forming a chemical bond with bone tissue. The chemical composition is MgO 4.6, CaO 44.9, SiO2 34.2, P2O5 16.3, and CaF2 0.5 in weight ratio. In this study the influence of substituting B2O3 for CaF2 on the bonding behaviour of glass-ceramics containing apatite and wollastonite to bone tissue was investigated. Two kinds of glass-ceramics containing apatite and wollastonite were prepared. CaF2 0.5 was replaced with B2O3 at 0.5 and 2.0 in weight ratio (designated AWGC-0.5B and AWGC-2.0B). Rectangular ceramic plates (15 x 10 x 2 mm, abraded with No. 2000 alumina powder) were implanted into a rabbit tibia. The failure load, when an implant detached from the bone, or the bone itself broke, was measured. The failure load of AWGC-0.5B was 8.00 +/- 1.82 kg at 10 weeks after implantation and 8.16 +/- 1.36 kg at 25 weeks after implantation. The failure load of AWGC-2B was 8.08 +/- 1.70 kg at 10 weeks after implantation and 9.92 +/- 2.46 kg at 25 weeks after implantation. None of the loads for the two kinds of glass-ceramics decreased as time passed. Giemsa surface staining and contact microradiography revealed direct bonding between glass-ceramics and bone. SEM-EPMA showed a calcium-phosphorus rich layer (reaction zone) at the interface of ceramics and bone tissue. The thickness of the reaction zone was 10 to -15 microns and did not increase as time passed.(ABSTRACT TRUNCATED AT 250 WORDS)
Kitsugi
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Department of Orthopaedic Surgery, Faculty of Medicine, University of Kyoto, Japan.
Yamamuro
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Nakamura
T
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Yoshii
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S
Kokubo
T
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Takagi
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M
Shibuya
T
T
D000818:Animals; D001031:Apatites; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001843:Bone Cements; D001842:Bone and Bones / Q000033:anatomy & histology / Q000502:physiology / Q000601:surgery; D001895:Boron; D001896:Boron Compounds; D017610:Calcium Compounds; D002124:Calcium Fluoride; D002516:Ceramics; D005898:Glass; D008297:Male; D008422:Materials Testing; D019736:Prostheses and Implants; D011817:Rabbits; D017640:Silicates; D012824:Silicic Acid
D001031:Apatites; D001672:Biocompatible Materials; D001843:Bone Cements; D001896:Boron Compounds; D017610:Calcium Compounds; D017640:Silicates; D012824:Silicic Acid; C042168:boron oxide; D001895:Boron; D002124:Calcium Fluoride; C031293:calcium silicate