Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in mice.
The efficacy of oxime (HI-6, toxogonin or PAM Cl) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combinations of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffective. HI-6 was the only oxime which reactivated GF inhibited acetylcholinesterase. This might explain the reason why the HI-6 treated mice appeared to recover more quickly from the incapacitating effects following GF poisoning.
Clement
J G
JG
Biomedical Defence Section, Defence Research Establishment Suffield, Ralston, Alta., Canada.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001285:Atropine / Q000627:therapeutic use; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000627:therapeutic use; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009422:Nervous System Diseases / Q000139:chemically induced / Q000517:prevention & control*; D009768:Obidoxime Chloride / Q000627:therapeutic use; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000032:analysis; D010091:Oximes / Q000627:therapeutic use*; D011220:Pralidoxime Compounds / Q000627:therapeutic use; D011726:Pyridinium Compounds / Q000627:therapeutic use
D000931:Antidotes; D002619:Chemical Warfare Agents; D002801:Cholinesterase Reactivators; D009943:Organophosphorus Compounds; D010091:Oximes; D011220:Pralidoxime Compounds; D011726:Pyridinium Compounds; D009768:Obidoxime Chloride; D001285:Atropine; C022870:asoxime chloride; C028797:pralidoxime; C053914:cyclohexyl methylphosphonofluoridate