[The effect of a combination of propofol and fentanyl on cerebral blood flow. A study using transcranial doppler].
The results of the association propofol fentanyl on the velocity of the middle cerebral artery were studied by means of a transcranial doppler on twenty ASA I patients without any intracranial pathology. Anaesthesia induction by propofol (2.5 mg.kg-1) and fentanyl (2 micrograms.kg-1) induced a significant fall of average velocities (p: 0.0001) and an increase of the resistance index (p: 0.0001) without any associated variation of mean blood pressure and CO2 expiratory fraction. These results corroborate the variations of cerebral blood flow and cerebral vascular resistances reported in the literature and give evidence, in all probability, of a cerebral autoregulation phenomenon.
Boishardy
N
N
Département d'Anesthésie-Réanimation, CHRU, Angers.
Chapotte
C
C
Houi
N
N
Poirier
T
T
Granry
J C
JC
Delhumeau
A
A
D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D002536:Cerebral Arteries / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002648:Child; D005260:Female; D005283:Fentanyl; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D015742:Propofol; D014465:Ultrasonics; D014463:Ultrasonography
D005283:Fentanyl; D015742:Propofol
Effet de l'association propofol-fentanyl sur les flux sanguins cérébraux. Etude par doppler transcrânien.