title: Lactate transport during differentiation of skeletal muscle cells: evidence for a specific carrier in L6 myotubes.
abstract: Cellular uptake of lactate involves a carrier in numerous types of mammalian cells. In cultured rat L6 myoblasts, lactate diffuses freely. We show that during myogenesis a carrier appears at the myotube stage. The degree of cellular differentiation was determined by microscopic observation and by measurement of a marker of biochemical differentiation: the increase in specific activity of creatine kinases.
authors.affiliation: Laboratoire de physiologie des adaptations, CHU Cochin, Paris, France.
authors.forename: K
authors.initials: K
authors.lastname: el Abida
authors.forename: A
authors.initials: A
authors.lastname: Duvallet
authors.forename: L
authors.initials: L
authors.lastname: Thieulart
authors.forename: M
authors.initials: M
authors.lastname: Rieu
authors.forename: M
authors.initials: M
authors.lastname: Beaudry
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002454:Cell Differentiation; D002478:Cells, Cultured; D003402:Creatine Kinase / Q000378:metabolism; D007700:Kinetics; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D009132:Muscles / Q000166:cytology / Q000378:metabolism*
chemical_list: D007773:Lactates; D019344:Lactic Acid; D003402:Creatine Kinase