A transcription-dependent DNase I-hypersensitive site in a far upstream segment of the chicken alpha-globin gene domain coincides with a matrix attachment region.
A site of hypersensitivity to DNase I has been found at the 5'-side of the chicken alpha-globin gene domain, ca. 8 Kbp upstream to the first gene. The presence of this site in different types of chicken cells correlates with the transcriptional status of the domain. A matrix attachment region (MAR) has also been found in the same subfragment, suggesting that it may be involved in the control of transcription of the chicken alpha-globin genes.
de Moura Gallo
C V
CV
Institut Jacques Monod, Université Paris 7, France.
Vassetzky
Y S
YS
Huesca
M
M
Scherrer
K
K
D001355:Alpharetrovirus / Q000235:genetics; D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D002645:Chickens; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification / Q000378:metabolism; D003850:Deoxyribonuclease I; D004912:Erythrocytes / Q000502:physiology; D005796:Genes; D005914:Globins / Q000235:genetics* / Q000378:metabolism; D008970:Molecular Weight; D005810:Multigene Family; D015530:Nuclear Matrix / Q000378:metabolism*; D015183:Restriction Mapping; D014158:Transcription, Genetic
D005914:Globins; D004247:DNA; D003850:Deoxyribonuclease I