Tumor markers of epithelial and stromal cell origin at second-look laparotomy in ovarian carcinoma.
The accuracy of CA 125, amino-terminal propeptide of type III procollagen (PIIINP), and clinical examination were evaluated in association with 48 second-look laparotomies of ovarian carcinoma patients treated with cytotoxic chemotherapy. At laparotomy, there were 23 macroscopical and 6 microscopical tumors. Nineteen patients were disease-free. Clinical examination, CA 125, and PIIINP were correctly positive in 93, 92, and 82% of cases, respectively. When CA 125 and PIIINP were used simultaneously this value increased to 100%. The sensitivity of CA 125 (43%) and PIIINP (56%) was unsatisfactory, but with their combination it increased to 62%. The use of CA 125, PIIINP, or both increased the sensitivity of clinical examination by 14, 24, and 27%, respectively. Of all the occult tumors, CA 125 detected 33%, PIIINP 57%, and both 66%. The detection rate of macroscopical tumors missed at clinical examination by both was 71%. Hence, PIIINP may be a clinically valuable complement to CA 125 and clinical examination before second-look laparotomy.
Tomás
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Department of Obstetrics and Gynecology, University of Oulu, Finland.
Kauppila
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D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D007813:Laparotomy; D008875:Middle Aged; D009994:Osmolar Concentration; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000473:pathology; D010446:Peptide Fragments / Q000032:analysis*; D011237:Predictive Value of Tests; D011347:Procollagen / Q000032:analysis*; D012086:Reoperation; D012680:Sensitivity and Specificity
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide