Synthesis and pharmacology of some new carbamodithioic acid esters.
In this study 13 new dithiocarbamates were prepared by reacting 3-methyl-6-chloroacetyl-benzoxazolinone with potassium N,N-disubstituted dithiocarbamate derivatives. The structures of the compounds were confirmed by UV, IR, 1H-NMR, mass spectroscopic methods and elementary analysis. The anticholinergic activity was tested on rabbit ileum. With exception of one compound all derivatives exhibited a stronger antihistaminic activity as compared with their anticholinergic action.
Safak
C
C
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Erdogan
H
H
Yesilada
A
A
Erol
K
K
Cimgi
I
I
D000818:Animals; D001583:Benzoxazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D002219:Carbamates / Q000032:analysis / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006633:Histamine Antagonists / Q000138:chemical synthesis*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis*; D011817:Rabbits; D013055:Spectrophotometry, Infrared
D001583:Benzoxazoles; D002219:Carbamates; D006633:Histamine Antagonists; D010276:Parasympatholytics