The occurrence of pericapillary fibrin in venous hypertension and ischaemic leg ulcers: a histopathological study.
The presence of pericapillary fibrin and complement C3c in the ulcers of 19 patients with venous hypertension and 14 patients with ischaemic leg ulcers was investigated using histochemical and immunohistochemical techniques. There was deposition of fibrin around the capillaries in the central part of the ischaemic ulcers, and the venous hypertension ulcers, and in the non-ulcerated skin around one of the venous hypertension ulcers and two of the ischaemic leg ulcers. The deposition of fibrin is a secondary phenomenon that occurs in the area of ulcerated skin and does not play a major causal role in the formation of chronic leg ulcers.
Balslev
E
E
Department of Pathology, Bispebjerg Hospital, Denmark.
Thomsen
H K
HK
Danielsen
L
L
Warburg
F
F
D000368:Aged; D000369:Aged, 80 and over; D002196:Capillaries / Q000378:metabolism / Q000473:pathology; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D005337:Fibrin / Q000032:analysis*; D006801:Humans; D007511:Ischemia / Q000150:complications; D007866:Leg / Q000098:blood supply; D007871:Leg Ulcer / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014690:Venous Pressure / Q000502:physiology*
D005337:Fibrin; D003165:Complement System Proteins