Nucleolar silver staining patterns of lymphocytes in sarcoidosis.
Bronchoalveolar lavage lymphocytes from 15 patients with pulmonary sarcoidosis and 8 healthy controls were investigated for nucleolar silver staining patterns and lymphocyte subpopulations. Patients with sarcoidosis had increased numbers of silver stained dots versus controls (2.20 +/- 0.24 versus 1.78 +/- 0.07; p less than 0.001). The number of silver stained dots showed the strongest positive correlation to helper cells (OKT 4+) (r = 0.781; p less than 0.0001). These results may be interpreted as further evidence of lymphocytic activation, especially of helper cells (OKT 4+) in pulmonary sarcoidosis.
Popp
W
W
Lungenabteilung, KH der Stadt Wien-Lainz, Vienna, Austria.
Zwick
H
H
Wanke
T
T
Braun
O
O
Holzner
J H
JH
Wachtler
F
F
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D002466:Cell Nucleolus / Q000737:chemistry*; D005260:Female; D006801:Humans; D016131:Lymphocyte Subsets / Q000737:chemistry* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis*; D009697:Nucleolus Organizer Region / Q000737:chemistry; D012016:Reference Values; D012507:Sarcoidosis / Q000473:pathology*; D016622:Silver Staining
D009687:Nuclear Proteins