Mechanisms of signal transduction by Ras.
The role of Ras in the transduction of signals that control cell growth is undisputed. However, the identity of the Ras signalling pathway remains unknown. Evidence is mounting that Ras can receive signals from different cell surface receptors most likely via a common intermediate, GAP. A new insight into the possible function of Ras is provided by the recent findings that certain ligands can induce the coordinated redistribution of Ras and cell surface receptors. The next challenge is to identify the specific targets for the action of Ras.
Bar-Sagi
D
D
Cold Spring Harbor Laboratory, NY 11724.
D000818:Animals; D002455:Cell Division / Q000502:physiology; D020690:GTPase-Activating Proteins; D005786:Gene Expression Regulation / Q000502:physiology; D011905:Genes, ras / Q000502:physiology*; D006153:Guanosine Diphosphate / Q000378:metabolism / Q000502:physiology; D006160:Guanosine Triphosphate / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D011506:Proteins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D020703:ras GTPase-Activating Proteins
D020690:GTPase-Activating Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D020703:ras GTPase-Activating Proteins; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate