[Effects of silybin on acute myocardial infarction and reperfusion injury in anesthetized rats].
The effects of silybin (Sil) on myocardial infarction size and ischemia- and reperfusion-induced arrhythmias were studied in anesthetized open chest Sprague-Dawley rats. It was found that pretreatment with Sil 20, 50, and 80 mg.kg-1 iv reduced significantly infarct size by 34.7%, 35.0%, and 50.6% respectively at 4 h after ligation. Sil prevented ischemic arrhythmia only at the dose of 80 mg.kg-1. In reperfusion experiment, pretreatment with Sil 20 mg.kg-1 decreased significantly reperfusion-induced arrhythmia.
Chen
H
H
Department of Cardiology, Changhai Hospital, Shanghai, China.
Su
D F
DF
Zhang
T H
TH
Ding
H J
HJ
Yang
Y C
YC
Chen
S C
SC
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000150:complications; D051381:Rats; D011919:Rats, Inbred Strains; D012838:Silymarin / Q000627:therapeutic use*
D012838:Silymarin