Effect of progesterone and oestradiol benzoate on oestrous behaviour and secretion of luteinizing hormone in ovariectomized fallow deer (Dama dama).
Eighteen ovariectomized fallow deer does and two adult bucks were used to investigate the effect of exogenous progesterone and oestradiol benzoate on oestrous behaviour and secretion of luteinizing hormone (LH). In Expts 1 and 2, conducted during the breeding season (April-September), does were treated with intravaginal Controlled Internal Drug Release (CIDR) devices (0.3 g progesterone per device) for 12 days and differing doses of oestradiol benzoate administered 24 h after removal of the CIDR device. The dose had a significant effect on the proportion of does that exhibited oestrus within the breeding season (P less than 0.001), the incidence of oestrus being 100% with 1.0, 0.1 and 0.05 mg, 42% for 0.01 mg and 0% for 0.002 mg oestradiol benzoate. There was a significant log-linear effect of dose on the log duration of oestrus, which was 6-20, 2-14, 2-12 and 2 h after treatment with 1, 0.1, 0.05 and 0.01 mg of oestradiol benzoate, respectively. Dose had a significant effect on the peak plasma LH concentration (P less than 0.01), mean (+/- s.e.m.) surge peaks of 27.7 +/- 2.3, 25.9 +/- 1.8 and 18.6 +/- 3.4 ng/ml being observed following treatment with 1, 0.1 and 0.01 mg oestradiol benzoate respectively. In Expt 3, also conducted during the breeding season, progesterone treatment (0 vs. 6-12 days) before the administration of 0.05 mg oestradiol benzoate had a significant effect on the incidence of oestrus (0/6 vs. 10/12, P less than 0.05), but not on LH secretion. The duration of progesterone treatment (6 vs. 12 days) had no effect on oestrus.(ABSTRACT TRUNCATED AT 250 WORDS)
Jabbour
H N
HN
Ruakura Agricultural Centre, Ministry of Agriculture and Fisheries, Hamilton, New Zealand.
Asher
G W
GW
Smith
J F
JF
Morrow
C J
CJ
D000818:Animals; D003670:Deer / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008550:Melatonin / Q000494:pharmacology; D010052:Ovariectomy; D011374:Progesterone / Q000494:pharmacology; D012621:Seasons
D012739:Gonadal Steroid Hormones; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D008550:Melatonin