Early endotoxin tolerance in suckling rats.
Early endotoxin tolerance has not been well investigated in the newborn. This study demonstrated that a sublethal dose of Salmonella enteritidis lipopolysaccharide (S. ent-LPS) or rough mutant Salmonella minnesota LPS (Re-LPS) induced early endotoxin tolerance in suckling rats, showing blunted hypoglycemia and decreased mortality. The mortality of endotoxic shock was lower in S. ent-LPS pretreated group than Re-LPS pretreated group. A sublethal dose of S. ent-LPS caused lactacidemia but Re-LPS did not. Therefore, early endotoxin tolerance appeared to be related to physiologic responses to the initial LPS exposure.
Goto
M
M
Department of Pediatrics, Loyola University of Chicago, Maywood 60153.
Yoshioka
T
T
Young
R
R
Gottschalk
M E
ME
Anderson
C L
CL
Zeller
W P
WP
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001786:Blood Glucose / Q000378:metabolism; D004731:Endotoxins / Q000633:toxicity*; D007773:Lactates / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012475:Salmonella / Q000378:metabolism
D001786:Blood Glucose; D004731:Endotoxins; D007773:Lactates; D008070:Lipopolysaccharides