title: Dual-action penems and carbapenems.
abstract: Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed for both classes of compounds, indicative of a dual-mode of action.
authors.affiliation: Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
authors.forename: A J
authors.initials: AJ
authors.lastname: Corraz
authors.forename: S L
authors.initials: SL
authors.lastname: Dax
authors.forename: N K
authors.initials: NK
authors.lastname: Dunlap
authors.forename: N H
authors.initials: NH
authors.lastname: Georgopapadakou
authors.forename: D D
authors.initials: DD
authors.lastname: Keith
authors.forename: D L
authors.initials: DL
authors.lastname: Pruess
authors.forename: P L
authors.initials: PL
authors.lastname: Rossman
authors.forename: R
authors.initials: R
authors.lastname: Then
authors.forename: J
authors.initials: J
authors.lastname: Unowsky
authors.forename: C C
authors.initials: CC
authors.lastname: Wei
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D015780:Carbapenems / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems