Dorsal tegmentum kindling in rats.
Electrical stimulations were applied daily for 40 days to the dorsal tegmentum in 9 rats through chronically implanted bipolar electrodes. The intensity of current (2 s trains of 50 Hz, 1 ms monophasic square waves) necessary to trigger a full tonic seizure was determined and applied for all further stimulations. Initial stimulations induced a tonic seizure with a low voltage fast electrocorticographic activity. After repeated stimulations, high amplitude spike and wave discharges developed over the cortex, their duration exceeding 50 s at the 40th stimulation. Simultaneously, the tonic seizures evolved into tonic-clonic fits with bilateral myoclonias following the tonic phase. These EEG and behavioral modifications persisted for 30 days after the last stimulus. These results demonstrate that kindling may be obtained from brainstem structures.
Maton
B
B
Clinique Neurologique, C.H.U., Strasbourg, France.
Hirsch
E
E
Vergnes
M
M
Depaulis
A
A
Marescaux
C
C
D000818:Animals; D004558:Electric Stimulation; D004569:Electroencephalography; D005625:Frontal Lobe / Q000502:physiology* / Q000503:physiopathology; D007696:Kindling, Neurologic; D008297:Male; D009043:Motor Activity; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology; D013681:Tegmentum Mesencephali / Q000502:physiology* / Q000503:physiopathology; D013997:Time Factors