title: Effects of recombinant human interleukin-6 alone and in combination with recombinant interleukin-1 alpha and tumor necrosis factor alpha on antibacterial resistance in mice.
abstract: In this study, recombinant human interleukin-6 (rIL-6) was tested for its ability to alter the resistance of mice to experimental Listeria monocytogenes infection. Single bolus or repeated injections of rIL-6 by itself did not increase antilisteria resistance. When rIL-6 was injected in combination with suboptimal concentrations of rIL-1 alpha and tumor necrosis factor alpha (rTNF-alpha), it did not augment their abilities to mediate protection in the spleen and had a marginal effect on the level of protection in the liver. Injection of rIL-6 together with protective doses of rIL-1 alpha did not diminish the protection stimulated by the latter. Unlike rIL-1 alpha and recombinant tumor necrosis factor alpha, rIL-6 appears to have little ability to elevate antibacterial resistance.
authors.affiliation: Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
authors.forename: C J
authors.initials: CJ
authors.lastname: Czuprynski
authors.forename: M
authors.initials: M
authors.lastname: Haak-Frendscho
authors.forename: N
authors.initials: N
authors.lastname: Maroushek
authors.forename: J F
authors.initials: JF
authors.lastname: Brown
mesh_terms: D000818:Animals; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007275:Injections, Intravenous; D007375:Interleukin-1 / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000008:administration & dosage / Q000627:therapeutic use*; D008089:Listeria monocytogenes / Q000187:drug effects / Q000276:immunology; D008088:Listeriosis / Q000276:immunology / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha