title: Testotoxicosis: gonadotrophin-independent male sexual precocity.
abstract: In this era of rapidly developing investigational tools and pharmacology, the pathophysiology of precocious puberty is becoming well defined. What was previously thought to be a form of gonadotrophin releasing hormone (GNRH)-dependent central precocious puberty is now classified as GNRH-independent familial testotoxicosis. We present two such cases and review the clinical features, pathophysiology and treatment of testotoxicosis.
authors.affiliation: Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: A A
authors.initials: AA
authors.lastname: Aziz
authors.forename: S M
authors.initials: SM
authors.lastname: Jafri
authors.forename: N U
authors.initials: NU
authors.lastname: Haque
mesh_terms: D002648:Child; D002675:Child, Preschool; D005837:Genitalia, Male / Q000473:pathology; D006801:Humans; D008297:Male; D011629:Puberty, Precocious / Q000097:blood* / Q000473:pathology; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone