title: Myeloblastic leukemoid reaction in paroxysmal nocturnal hemoglobinuria associated with myelodysplasia.
abstract: Paroxysmal nocturnal hemoglobinuria (PNH) has been observed to evolve into myelofibrosis and acute myeloid leukemia. Myeloblastic leukemoid reaction has not been described in PNH. We described a patient with PNH with myelodysplasia and septicemia. The marrow aspirates showed a picture of myeloblastosis which subsided when sepsis was controlled. The myeloblastic leukemoid reaction in our patient related to overwhelming sepsis, splenectomy and overt hemolysis.
authors.affiliation: Department of Internal Medicine, Tri-Service General Hospital, National Defence Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: W S
authors.initials: WS
authors.lastname: Ko
authors.forename: L M
authors.initials: LM
authors.lastname: Chen
authors.forename: T Y
authors.initials: TY
authors.lastname: Chao
authors.forename: W S
authors.initials: WS
authors.lastname: Hwang
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006801:Humans; D007955:Leukemoid Reaction / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000473:pathology; D018805:Sepsis / Q000150:complications / Q000628:therapy