title: [Spinal leptomeningeal tumor spread disclosing a pineocytoma].
abstract: A 39-year-old female was admitted to the hospital because of a sudden meningeal syndrome followed by diplopia, cervical, dorsal and sciatic nerve pains, and right peripheral facial palsy. Cerebrospinal fluid obtained by lumbar puncture showed a protein level at 23 g/l. Myelography and magnetic resonance imaging (MRI) were in favor of a lumbar arachnoiditis. A meningeal biopsy revealed a tumour infiltration with foci of cells that were stained with anti-glial fibrillary acidic protein antibody. Cerebral MRI was performed to search for a central nervous system (CNS) primary tumour, and disclosed a pineal mass. Five months after the onset of the disease, the patient worsened her clinical state and died. Necropsy confirmed the presence of a pineocytoma with astrocytic differentiation and diffuse leptomeningeal spread. This exceptional occurrence leads us to discuss about primary tumours of the CNS with leptomeningeal spread.
authors.affiliation: Service d'Anatomie Pathologique, Hôpital Albert Michallon.
authors.forename: B
authors.initials: B
authors.lastname: Pasquier
authors.forename: F
authors.initials: F
authors.lastname: Le Marc'Hadour
authors.forename: A
authors.initials: A
authors.lastname: Dieny
authors.forename: A
authors.initials: A
authors.lastname: Ciapa
authors.forename: T
authors.initials: T
authors.lastname: Lefrancq
authors.forename: F
authors.initials: F
authors.lastname: Bost
authors.forename: S
authors.initials: S
authors.lastname: Martal
authors.forename: M
authors.initials: M
authors.lastname: Micoud
authors.forename: D
authors.initials: D
authors.lastname: Pasquier
mesh_terms: D000328:Adult; D001099:Arachnoid; D001706:Biopsy; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000556:secondary*; D010870:Pineal Gland; D010871:Pinealoma / Q000556:secondary*
vernacular_title: Essaimage tumour leptomeninge spinal révélateur d'un pineocytome.