Tissue distribution of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in two strains of male rats.
Albino and hooded male rats were administered 14C-labeled 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) by gavage. The tissue distribution was investigated by means of whole-body autoradiography and liquid scintillation counting. MeIQx was rapidly absorbed from the alimentary tract and distributed to several tissues. The major predilection sites were the liver and kidneys. The amount of radioactivity decreased dramatically within a few days. However, unextractable radioactive material was still detectable in these organs 6 days after the administration.
Tjøtta
K
K
Department of Food Hygiene, Norwegian College of Veterinary Medicine, Oslo.
Ingebrigtsen
K
K
Aune
T
T
D000818:Animals; D001345:Autoradiography; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009153:Mutagens / Q000008:administration & dosage / Q000493:pharmacokinetics; D011810:Quinoxalines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D012867:Skin / Q000378:metabolism; D013045:Species Specificity; D014018:Tissue Distribution
D009153:Mutagens; D011810:Quinoxalines; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline