title: Meiotic delay of mouse spermatocytes carrying x-ray-induced translocations.
abstract: The kinetics of spermatocyte progression through meiotic prophase in cells with or without induced translocations were studied in mice that had been exposed to x-rays. Pulse-labeling experiments using 3H-thymidine, followed by autoradiographic analysis, indicated that at higher x-ray doses (6 and 7 Gy), translocation-carrying cells tend to spend more time in meiotic prophase than do normal cells. At 2 Gy, no such delay seemed to be present. The observed delay may explain the reduction in transmission of translocations to the next generation reported by others.
authors.affiliation: MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.
authors.forename: P P
authors.initials: PP
authors.lastname: van Buul
authors.forename: C M
authors.initials: CM
authors.lastname: Seelen
authors.forename: J H
authors.initials: JH
authors.lastname: Goudzwaard
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008297:Male; D008540:Meiosis / Q000235:genetics / Q000528:radiation effects*; D051379:Mice; D011418:Prophase / Q000235:genetics / Q000528:radiation effects*; D013090:Spermatocytes / Q000502:physiology / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000235:genetics / Q000528:radiation effects*