title: Ifosfamide in plasma cell leukemia: a report of two cases and review of the literature.
abstract: We report two patients with primary plasma cell leukemia (PLC) treated with a single agent, ifosfamide. One patient had a total disappearance of plasma cells (PC) from the peripheral blood and the bone marrow and disappearance of the myeloma protein, is disease free 8 months after completion of treatment, and alive 14 months after diagnosis. The second patient had a partial response with persistence of plasma cells in the bone marrow lasting 7 months, after which she had a frank relapse of the disease. We suggest that ifosfamide may be an active agent in plasma cell malignancies and needs further evaluation in multiple myeloma.
authors.affiliation: Department of Medical Oncology, Tata Memorial Hospital, Bombay, India.
authors.forename: H
authors.initials: H
authors.lastname: Malhotra
authors.forename: B N
authors.initials: BN
authors.lastname: Dhabhar
authors.forename: T K
authors.initials: TK
authors.lastname: Saikia
authors.forename: R
authors.initials: R
authors.lastname: Gopal
authors.forename: K S
authors.initials: KS
authors.lastname: Nadkarni
authors.forename: C N
authors.initials: CN
authors.lastname: Nair
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D007952:Leukemia, Plasma Cell / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D007069:Ifosfamide