title: Regulation of histone gene expression.
abstract: Histone genes are expressed during the S phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell-cycle progression and the onset of differentiation. Much work has been carried out on the H4 gene promoter, which appears to be organized into a series of distinct regulatory elements. The three-dimensional organization of the promoter and, in particular, its spatial relationship with the nuclear matrix scaffold, may be important factors of transcription regulation.
authors.affiliation: University of Massachusetts Medical Center, Worcester.
authors.forename: G S
authors.initials: GS
authors.lastname: Stein
authors.forename: J L
authors.initials: JL
authors.lastname: Stein
authors.forename: A J
authors.initials: AJ
authors.lastname: van Wijnen
authors.forename: J B
authors.initials: JB
authors.lastname: Lian
mesh_terms: D001483:Base Sequence; D002453:Cell Cycle / Q000235:genetics; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D006657:Histones / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic
chemical_list: D006657:Histones; D004247:DNA