title: Primary localized amyloidosis of the bladder: a case of AL (lambda) amyloid protein and combination therapy using dimethyl sulfoxide and cepharanthin.
abstract: We report a case of primary localized amyloidosis of the bladder with amyloid deposits which was characterized as being of immunoglobulin light chain origin (AL) including lambda type (A lambda) and P component (AP) using the KMnO4 pretreatment method and immunohistochemical procedures. The patient was treated successfully with intravesical dimethyl sulfoxide instillation and oral administration of high-dose cepharanthin after transurethral resection. Combination therapy with dimethyl sulfoxide and cepharanthin was shown to be useful for primary localized amyloidosis of the bladder.
authors.affiliation: Department of Urology, Niigata University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishiyama
authors.forename: F
authors.initials: F
authors.lastname: Gejyo
authors.forename: Y
authors.initials: Y
authors.lastname: Katayama
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D000368:Aged; D000470:Alkaloids / Q000627:therapeutic use*; D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000188:drug therapy* / Q000378:metabolism; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D001743:Urinary Bladder / Q000737:chemistry; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000378:metabolism; D052117:Benzodioxoles
chemical_list: D000470:Alkaloids; D000682:Amyloid; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D044182:Benzylisoquinolines; D004121:Dimethyl Sulfoxide; C035222:amyloid protein AL; C006947:cepharanthine; D052117:Benzodioxoles