[Pathogenetic and clinical significance of peripheral activated T-lymphocyte subsets in Basedow's disease].
The peripheral activated T-cell subsets which express concurrently DR and CD antigens were determined in 22 patients with Graves' disease using the fluorescence-rosette double labelling technique. In the active phase of the disease a decrease in the percentage of CD8+ cells, an increase in the CD4+/CD8+ ratio and an elevation of various DR+CD+T-lymphocytes was found. A concurrent marked increase in DR+CD4+ cells accounts for an abnormality in the equilibrium of activated T-lymphocyte subsets and an increase in DR+CD4+/DR+CD8+ ratios. In comparison with the active phase the DR+CD3+ and DR+CD4+ cells decreased in remission, but DR+CD8+ cells remained unchanged. The decrease in the ratio of CD4+/CD8+ cells was less marked than that of the DR+CD4+/DR+CD8+ cells, which fell into the normal range. Our results suggest an excessive activation of T-helper cells as well as a deficiency in T-suppressor cells which may play an important role in the pathogenesis of Graves' disease.
Wenjuan
D
D
Forschungszentrum für experimentelle Medizin, Tongji Medizinische Universität, Wuhan, Volksrepublik China.
Shen
G
G
Ye
W
W
D000328:Adult; D015704:CD4 Antigens / Q000302:isolation & purification; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens / Q000302:isolation & purification; D005260:Female; D006111:Graves Disease / Q000097:blood*; D006684:HLA-DR Antigens / Q000302:isolation & purification; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens
Pathogenetische und klinische Bedeutung von Subpopulationen aktivierter T-Lymphozyten im peripheren Blut bei Morbus Basedow.