title: Transfusion-associated graft-versus-host disease in a presumably immunocompetent patient after transfusion of stored packed red cells.
abstract: A 54-year-old woman developed transfusion-associated graft-versus-host disease (TA-GVHD) after the transfusion of stored packed red cells obtained from unrelated donors. The patient was presumed to be immunocompetent. A diagnosis of TA-GVHD was made by clinical features and postmortem pathologic findings. Sex chromatin analysis of the patient's lymphocytes demonstrated chimerism. HLA typing of the blood donors revealed one to be HLA-homozygous for one of the patient's HLA haplotypes (A33-B44-Cblank). This case illustrates the risk in the general patient population of TA-GVHD after routine blood transfusion therapy. Workers should be aware of this possibility and should continue searching for an efficient way to prevent it.
authors.affiliation: Department of Hematology, Tokyo Metropolitan Komagome Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: S
authors.initials: S
authors.lastname: Takamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Sakamaki
authors.forename: K
authors.initials: K
authors.lastname: Akagi
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: M
authors.initials: M
authors.lastname: Takenaka
authors.forename: Y
authors.initials: Y
authors.lastname: Onozawa
mesh_terms: D016913:Blood Component Transfusion / Q000009:adverse effects*; D001782:Blood Donors; D002843:Chromatin / Q000302:isolation & purification; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics; D006239:Haplotypes; D006400:Hematocrit; D006801:Humans; D007121:Immunocompetence; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D002843:Chromatin; D006680:HLA Antigens