title: Neurocirculatory asthenia revisited: elevated arterial pressure at presentation is a marker for subsequent hypertension.
abstract: Neurocirculatory asthenia (NCA) is a fairly common functional disorder often encountered among military recruits. Symptoms in NCA tend to appear in waves, and are believed to disappear completely with the passage of time. Elevated arterial pressure is known to occur as part of the various haemodynamic manifestations of NCA. However, the exact prevalence of hypertension, as well as its long-term prognosis, is still unknown. The present case-control study was designed to address these two issues. The target population consisted of 370 patients with NCA representing two separate cohorts: patients diagnosed in 1979, 10 years prior to this study, and patients diagnosed in 1983-84, 5 years prior to the study. An overall 20% prevalence rate of mild hypertension at diagnosis was calculated for the entire study population. In total, 100 patients representing equal numbers of hypertensive and matched normotensive subjects from each cohort were re-evaluated. At follow-up, hypertension was present in 27% (1979 cohort) and 30% (1983-84 cohort) of patients originally considered to be hypertensive. Hypertension was either non-existent (1979 cohort) or limited to a single case (1983-84 cohort) among originally normotensive individuals. In parallel, resting heart rate was higher in the hypertensive subjects of the 1979 cohort both at presentation (85.5 +/- 3.2 vs. 73.7 +/- 2.4 beats min-1; P less than 0.005) and at follow-up (79.6 +/- 3.2 vs. 70.0 +/- 2.5 beats min-1; P less than 0.01). These results indicate that hypertension complicates the diagnosis of NCA in 20% of patients and that, contrary to common belief, it cannot be regarded as another transient manifestation of this condition. Thus hypertension in this context is, as in the younger members of the population in general, a major risk factor for lifelong hypertension, rather than an inconsequential phenomenon.
authors.affiliation: Institute of Endocrinology, Elias Sourasky-Tel Aviv Medical Center, Ichilov Hospital, Tel Aviv, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Lev
authors.forename: K
authors.initials: K
authors.lastname: Tordjman
authors.forename: A
authors.initials: A
authors.lastname: Pines
authors.forename: E Z
authors.initials: EZ
authors.lastname: Fisman
authors.forename: Y
authors.initials: Y
authors.lastname: Drory
authors.forename: N
authors.initials: N
authors.lastname: Stern
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001794:Blood Pressure; D015992:Body Mass Index; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D009449:Neurocirculatory Asthenia / Q000150:complications*; D012307:Risk Factors; D013997:Time Factors