title: Systemic immunostimulation after retinal laser treatment in retinitis pigmentosa.
abstract: Systemic immunostimulation followed an experimental treatment trial of scatter argon laser photocoagulation directed to the retina of one eye of 10 patients with heredo-degenerative retinitis pigmentosa (RP). Significantly increased RP lymphocyte CD25, CD26, and CD4/CD26 activation epitope expressions over prelaser values and controls were found with a normalization of soluble interleukin-2 receptor secretion after laser treatment. Serum interferon-gamma was low both pre- and postlaser. Interestingly, when a panel of viral antibodies was tested, only those to rubella virus were elevated in the early postlaser period. The character of RP immunostimulation after laser-induced inflammation could be consistent with an antigenic stimulus from laser-released retinal proteins which might be of autoimmune or latent infectious origin. Enhanced immune responses may be a common but unrecognized sequellae of retinal laser.
authors.affiliation: Department of Ophthalmology, Ohio State University College of Medicine, Columbus.
authors.forename: L L
authors.initials: LL
authors.lastname: Williams
authors.forename: B T
authors.initials: BT
authors.lastname: Shannon
authors.forename: R B
authors.initials: RB
authors.lastname: Chambers
authors.forename: L E
authors.initials: LE
authors.lastname: Leguire
authors.forename: F H
authors.initials: FH
authors.lastname: Davidorf
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000378:metabolism; D000917:Antibody Formation; D000943:Antigens, Differentiation / Q000378:metabolism; D005434:Flow Cytometry; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000378:metabolism; D007834:Lasers; D007958:Leukocyte Count; D008028:Light Coagulation; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000737:chemistry / Q000378:metabolism; D012174:Retinitis Pigmentosa / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D012995:Solubility
chemical_list: D000914:Antibodies, Viral; D000943:Antigens, Differentiation; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma