Elevated lead levels in a patient with sickle cell disease and inappropriate secretion of antidiuretic hormone.
A five-year-old girl with known sickle cell disease presented with severe hyponatremia and findings compatible with syndrome of inappropriate secretion of antidiuretic hormone (SIADH). She was found to have lead levels in the Class III category. By exclusion, we postulated that the SIADH was in some way related to the high lead levels, since this was the only abnormality the patient exhibited. The toxic lead levels and the elevated vasopressin levels rapidly responded to dimercaprol and calcium EDTA chelation therapy.
Suarez
C R
CR
Department of Pediatrics, Loyola University Medical Center, Maywood, Illinois 60153.
Black
L E
LE
Hurley
R M
RM
D000755:Anemia, Sickle Cell / Q000150:complications*; D015913:Chelation Therapy; D002675:Child, Preschool; D004112:Dimercaprol / Q000627:therapeutic use; D004492:Edetic Acid / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000188:drug therapy; D007854:Lead / Q000097:blood*; D007855:Lead Poisoning / Q000188:drug therapy / Q000209:etiology*; D014667:Vasopressins / Q000097:blood
D004112:Dimercaprol; D014667:Vasopressins; D007854:Lead; D004492:Edetic Acid