Carbon catabolite regulation of gentamicin formation.
The effect of utilizable carbon sources on the production of gentamicin by Micromonospora purpurea has been studied. High D-glucose and D-xylose concentrations (40 mg/ml), exerted a strong and permanent negative action on antibiotic formation. On the other hand, similar concentrations of D-fructose, D-mannose, maltose and starch caused no effect. The glucose action is seen only if added during the logarithmic growth phase; moreover, the sugar needs to be metabolized to show its negative effect.
Escalante
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Departamento de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico D.F.
Gonzalez
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Obregon
A M
AM
Sanchez
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S
D050260:Carbohydrate Metabolism; D003470:Culture Media; D005839:Gentamicins / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D008847:Micromonospora / Q000378:metabolism*; D014994:Xylose / Q000378:metabolism*
D003470:Culture Media; D005839:Gentamicins; D014994:Xylose; D005947:Glucose