title: A nonsteroidal follicular factor is involved in maturation process of Xenopus laevis oocytes.
abstract: Xenopus laevis postvitellogenic ovarian follicles release into conditioned medium nonsteroidal factor(s) that potentiate progesterone-induced oocyte maturation. The molecular weight of this factor is between 1000 and 10,000 Da. The potentiating activity is suppressed when follicles are incubated with cyanoketone to inhibit steroidogenesis, suggesting that the secretion of the potentiating factor can be modulated in vitro. These results indicate that the steroid-independent pathway in vitro, previously reported in oocytes exposed to insulin or IGF-1 to induce meiotic resumption, may be of physiological importance.
authors.affiliation: Laboratoire de Biologie de la Reproduction, URA 256 CNRS, Université de Rennes I, France.
authors.forename: F
authors.initials: F
authors.lastname: Chesnel
authors.forename: A
authors.initials: A
authors.lastname: Bourry
authors.forename: D
authors.initials: D
authors.lastname: Boujard
authors.forename: J
authors.initials: J
authors.lastname: Joly
mesh_terms: D000818:Animals; D002606:Charcoal / Q000494:pharmacology; D003489:Cyanoketone / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry*; D007328:Insulin / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008540:Meiosis / Q000502:physiology; D009865:Oocytes / Q000737:chemistry / Q000502:physiology*; D009866:Oogenesis / Q000187:drug effects / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology; D012741:Sexual Maturation / Q000187:drug effects / Q000502:physiology; D014982:Xenopus laevis / Q000502:physiology*
chemical_list: D007328:Insulin; D002606:Charcoal; D003489:Cyanoketone; D011374:Progesterone; D007334:Insulin-Like Growth Factor I