Seasonal changes in thyroid-gonadal interactions in the edible dormouse, Glis glis.
This study was conducted to determine changes in thyroid-gonadal interaction in the edible dormouse during the phase of the annual cycle that corresponds to the end of the breeding season (from June to September). We evaluated intra-hypothalamic luteinizing hormone-releasing hormone (LHRH) content, and plasma concentrations of luteinizing hormone (LH), testosterone, thyroid-stimulating hormone (TSH) and thyroxine (T4) in three groups of dormice: (1) controls; (2) dormice receiving sufficient T4 supplementation to maintain June levels in control animals until September, thus counteracting the seasonal reduction of T4 that normally begins in July; and (3) thyroidectomized dormice. The effect of thyroidectomy was only detectable in June, when plasma T4 concentration in the control group was maximal, and consisted of a significant decrease in plasma testosterone levels. This provides strong support for the hypothesis that thyroid function positively influences gondal function during the breeding season. The T4 supplementation resulted in a decrease in hypothalamic LHRH concentration, suggesting that an increased LHRH release led to the observed stimulated hypophyseal secretion of LH in June and September and the increased circulating testosterone levels in September. There was no detectable effect in July and August. These results show that thyroid axis activation of the hypothalamic-pituitary-gondal system is only possible during certain phases of the annual cycle, particularly evidenced here during the breeding season. They also reinforce our conclusions drawn from the thyroidectomy results. Conversely, the summer testicular regression which normally occurs after the breeding season is no longer controlled by plasma T4 levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Jallageas
M
M
Laboratoire de Neurobiologie Endocrinologique, URA 1197, C.N.R.S., Université de Montpellier II, France.
Mas
N
N
Gautron
J P
JP
Saboureau
M
M
Roussel
J P
JP
D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis; D007031:Hypothalamus / Q000737:chemistry; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D012377:Rodentia / Q000502:physiology*; D012621:Seasons; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D013972:Thyrotropin; D013974:Thyroxine