Adipsic, but not anorectic, effect of fluprazine hydrochloride in rats.
The present experiment explored the anorectic and adipsic effects of fluprazine hydrochloride, a phenylpiperazine compound. Thirty-eight albino rats were randomly assigned either to a control saline group (six rats) or to groups (eight subjects each) receiving an IP dose of fluprazine in saline (1.25, 2.5, 5 or 10 mg/kg). No anorectic effect of the drug doses was observed 30, 60, 90, 120, 180 and 240 min, and 24 h after drug injection. However, water drinking was significantly decreased 30 min after drug administration, with 5 and 10 mg/kg, compared to saline.
Colotla
V A
VA
Facultad de Psicología, Universidad Nacional Autónoma de México, Coyoacán, D.F.
Mendoza L
D
D
Valencia-Flores
M
M
Dorantes
M E
ME
Luján
M
M
Campos-Sepúlveda
E
E
D000704:Analysis of Variance; D000818:Animals; D004435:Eating / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D013894:Thirst / Q000187:drug effects*
D010879:Piperazines; C035521:fluprazine