title: 1 alpha-hydroxycholecalciferol for the treatment of the downer cow syndrome.
abstract: Seventeen Holstein cows that showed clinical and biochemical symptoms (hypocalcemia and hypophosphatemia) of parturient hypocalcemia within 48 h postcalving and did not respond to Ca therapy were divided into two groups. Eight cows received a second intravenous Ca infusion 24 h after the first one. This treatment increased plasma Ca concentration but had no significant effect on phosphatemia, and the cows remained unable to rise and stand during 48 h following this second Ca infusion. The 9 other cows received 1 alpha-hydroxycholecalciferol (1 microgram/kg of BW, half the dose intravenously, the other half intramuscularly). 1 alpha-Hydroxycholecalciferol induced a significant increase in plasma P concentration and recovery of all the 9 cows within 12 h after this treatment.
authors.affiliation: Métabolisme Minéral Institut National de la Recherche Agronomique, St-Genès-Champanelle, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Barlet
authors.forename: M J
authors.initials: MJ
authors.lastname: Davicco
mesh_terms: D000818:Animals; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005260:Female; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous / Q000662:veterinary; D010319:Parturient Paresis / Q000188:drug therapy*; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy; D011897:Random Allocation
chemical_list: D006887:Hydroxycholecalciferols; D010758:Phosphorus; D002117:Calcitriol; D002118:Calcium; C008088:alfacalcidol