title: Trisomy 8p: unusual origin detected by fluorescence in situ hybridization.
abstract: Chromosomal analysis of a neonate with brain and heart abnormalities revealed trisomy for 8p. The mother's karyotype showed 47 chromosomes with one chromosome 8 being represented as two separate chromosomes, an acrocentric 8p and a telocentric 8q. G-banding and silver staining revealed a satellite and nucleolus organizing region (NOR) on the 8p. Centromeric-specific probes to the centromeres of chromosomes 8, 15, 13/21, 22 and the acrocentric chromosomes revealed that only the 8q centromere was of chromosome-8 origin, while the 8p centromere was of chromosome-14 origin.
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
authors.forename: K
authors.initials: K
authors.lastname: Barnum
authors.forename: C I
authors.initials: CI
authors.lastname: Kaye
authors.forename: K S
authors.initials: KS
authors.lastname: Kagan-Hallett
authors.forename: J C
authors.initials: JC
authors.lastname: Liang
mesh_terms: D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D015342:DNA Probes / Q000235:genetics; D005260:Female; D005453:Fluorescence; D006801:Humans; D007231:Infant, Newborn; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic / Q000235:genetics; D014314:Trisomy
chemical_list: D015342:DNA Probes