Genetic toxicology studies of an anti-AIDS drug.
SC-48334 (N-butyldeoxynojirimycin) is an experimental anti-AIDS drug which is currently in clinical trials. This drug is an aminosugar derivative. Its biological properties have been previously published [1]. Since many antiviral agents which are nucleic acid analogs exhibit mutagenic and/or clastogenic properties, the genotoxic potential of SC-48334 was examined in the Ames Salmonella/microsome assay, the Chinese hamster ovary cell/hypoxanthine guanine phosphoribosyl transferase (CHO/HGPRT) assay and the mouse bone marrow micronucleus assay. No toxic or mutagenic effects were observed in either the bacterial or mammalian in vitro mutation assays. Likewise, no clastogenic activity was observed in the in vivo micronucleus assay. Therefore, the administration of this drug in humans is not likely to have mutagenic effects and would probably not have a carcinogenic effect.
Oshiro
Y
Y
Research and Development Division, Searle, Skokie, IL 60077.
Guzzie
P J
PJ
Balwierz
P S
PS
Soelter
S G
SG
Rohrbacher
E
E
Gad
S C
SC
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D016466:CHO Cells / Q000187:drug effects / Q000201:enzymology; D006224:Cricetinae; D003412:Cricetulus; D004353:Drug Evaluation, Preclinical; D005260:Female; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D007041:Hypoxanthine Phosphoribosyltransferase / Q000187:drug effects / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D012475:Salmonella / Q000187:drug effects / Q000235:genetics
D000998:Antiviral Agents; D017485:1-Deoxynojirimycin; C059896:miglustat; D007041:Hypoxanthine Phosphoribosyltransferase; D005944:Glucosamine