title: Antiplatelet, anticoagulant and fibrinolytic agents in acute ischaemic stroke and TIA.
abstract: In acute ischaemic stroke and transient ischaemic attacks both platelets and coagulation factors are activated. This is the rationale for the use of antiplatelet and anticoagulant agents in the prevention of acute ischaemic stroke. Evidence also suggests that antiplatelet agents anticoagulants and dissolution of a thrombus occluding a major cerebral vessel (by means of fibrinolytic agents) may be beneficial as therapy for the acute phase of ischaemic stroke.
authors.affiliation: Department of Clinical Neurosciences, Western General Hospital, Edinburgh.
authors.forename: P
authors.initials: P
authors.lastname: Sandercock
authors.forename: R
authors.initials: R
authors.lastname: Lindley
authors.forename: J
authors.initials: J
authors.lastname: Wardlaw
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000517:prevention & control; D002985:Clinical Protocols / Q000592:standards; D016527:Drug Costs; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000517:prevention & control; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D011859:Radiography; D016032:Randomized Controlled Trials as Topic
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors