A comparison of the flanking regions of the mouse cytotoxic cell proteinase genes.
T lymphocyte activation correlates with the transcriptional induction of a variety of genes that encode proteins that are believed to play a role in specific effector functions of the mature cells. Transcripts corresponding to members of the cytotoxic cell proteinase (CCP) family of genes accumulate with different kinetics depending upon the nature of the T cell stimulus. The profile of expression for each family member is unique. Sequences corresponding to the 5' and 3' flanking regions of each of the CCP genes were isolated and sequenced. A comparison of these sequences reveal regions of conservation that are consistent with the differential expression observed and indicate potential regulatory elements.
Prendergast
J A
JA
Department of Biochemistry, University of Alberta, Edmonton, Canada.
Helgason
C D
CD
Bleackley
R C
RC
D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002460:Cell Line; D004247:DNA; D005786:Gene Expression Regulation; D053804:Granzymes; D051379:Mice; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D012697:Serine Endopeptidases / Q000235:genetics*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000201:enzymology*; D014158:Transcription, Genetic
D004247:DNA; D053804:Granzymes; D012697:Serine Endopeptidases