title: Supercritical fluid extraction of active components in a drug formulation.
abstract: Sulfamethoxazole and trimethoprim have been extracted from a drug formulation, Septra Infusion, with pure supercritical carbon dioxide. Both direct extraction of the aqueous-based matrix and indirect extraction of the formulation immobilized onto Celite were studied. Exhaustive analytical extraction was achieved when active components were less than 1.0 mg. A number of co-extractants were found, but each was blind to the HPLC/UV assay.
authors.affiliation: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061.
authors.forename: L J
authors.initials: LJ
authors.lastname: Mulcahey
authors.forename: L T
authors.initials: LT
authors.lastname: Taylor
mesh_terms: D004338:Drug Combinations; D013420:Sulfamethoxazole / Q000032:analysis*; D014295:Trimethoprim / Q000032:analysis*
chemical_list: D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole