title: Lack of bronchial hyperresponsiveness to methacholine and to isocapnic dry air hyperventilation in heart/lung and double-lung transplant recipients with normal lung histology. The Paris-Sud Lung Transplant Group.
abstract: To investigate whether survivors of heart/lung and double-lung transplantations have normal or increased nonspecific bronchial responsiveness, nine heart/lung and four double-lung transplant recipients with normal lung histology underwent methacholine challenge and voluntary isocapnic dry air hyperventilation (VIH) in a randomized order at a mean time of 14.8 +/- 12.1 months after surgery. Transplant recipients were compared with 10 normal subjects and 11 patients with mild asthma. Asthmatic patients had a mean provocative concentration of methacholine inducing a 20% fall (PC20) in FEV1 of 3.4 +/- 3.6 mg/ml (SD). Seventy seven percent of the transplant recipients and 70% of the normal subjects had PC20 superior to 32 mg/ml. The percentage fall from baseline FEV1 after VIH was 12.6 +/- 10.4% in asthmatic patients as compared with 1.9 +/- 2.9% in transplant recipients (p = 0.002) and 0.45 +/- 1.2% in normal subjects (p = 0.001). The decrease in FEV1 after VIH was similar in transplant recipients and normal subjects (p = 0.14). These results show that heart/lung or double-lung transplant recipients with normal lung histology have a normal response to nonspecific bronchial stimulation.
authors.affiliation: Laboratories d'Explorations Fonctionnelles Respiratories, Hôpital Marie-Lannelongue, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Herve
authors.forename: N
authors.initials: N
authors.lastname: Picard
authors.forename: M
authors.initials: M
authors.lastname: Le Roy Ladurie
authors.forename: D
authors.initials: D
authors.lastname: Silbert
authors.forename: J
authors.initials: J
authors.lastname: Cerrina
authors.forename: F
authors.initials: F
authors.lastname: Le Roy Ladurie
authors.forename: A
authors.initials: A
authors.lastname: Chapelier
authors.forename: P
authors.initials: P
authors.lastname: Dartevelle
authors.forename: G
authors.initials: G
authors.lastname: Simonneau
authors.forename: F
authors.initials: F
authors.lastname: Parquin
mesh_terms: D000328:Adult; D001249:Asthma / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000502:physiology; D005260:Female; D016041:Heart-Lung Transplantation / Q000502:physiology*; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology*; D016040:Lung Transplantation / Q000502:physiology*; D008297:Male; D016210:Methacholine Chloride; D008875:Middle Aged
chemical_list: D016210:Methacholine Chloride