Aggressive "breast-like" adenocarcinoma of vulva.
A case of vulvar adenocarcinoma seen in a 42-year-old woman is reported. The tumor involved the right labium majus and diffusely spread into the surrounding soft tissues as well as the inguinal lymph nodes and was histologically composed of nests, cords, and tubular formations recalling an aggressive duct carcinoma of breast. Likewise, tumor cells exhibited positivity for common breast tumor markers, such as epithelial membrane antigen, carcinoembryonic antigen, and glandular keratins. The possible origin of the neoplasm from mammary ectopic tissue in vulva or from vulvar skin adnexa is briefly discussed.
Di Bonito
L
L
Department of Anatomic Pathology, University of Trieste, Italy.
Patriarca
S
S
Falconieri
G
G
D000230:Adenocarcinoma / Q000473:pathology*; D001050:Apocrine Glands; D014408:Biomarkers, Tumor / Q000032:analysis; D001940:Breast; D002828:Choristoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D014846:Vulvar Neoplasms / Q000473:pathology*
D014408:Biomarkers, Tumor