title: 31P MRS as an early prognostic indicator of patient response to chemotherapy.
abstract: In this study 31P spectral changes were closely monitored following the initial administration of cytotoxic drugs and related to five parameters of patient response. Pre- and postchemotherapy 31P MRS examinations were performed on 16 patients with large, malignant tumors. These included four tumor types: (i) lymphoma (n = 7), (ii) breast carcinoma (n = 4), (iii) musculoskeletal tumors (n = 4), and (iv) adenocarcinoma (n = 1). A mean of 5 spectra/patient (range 2-10) was performed following the initial chemotherapy. The spectral trends exhibited by 14 of 16 patients reached "points of maximum change," after which they began to revert toward prechemotherapy values. In 2 of 16 patients that did not respond to the initial chemotherapy regimen, no spectral trends were observed. The degree of change of certain spectral parameters, namely, decreases in PME, PME/PDE, PME/PCr, PME/NTP, PDE/PCr, and tumor pH, as well as increases in the ratios Pi/PME and Pi/PDE, were associated with good patient response and separated responders from nonresponders. Pi/PME appears the most promising for discriminating partial from complete responders.
authors.affiliation: Institute of Radiological Sciences, Mater Misericordiae Hospital, Dublin, Ireland.
authors.forename: O M
authors.initials: OM
authors.lastname: Redmond
authors.forename: J P
authors.initials: JP
authors.lastname: Stack
authors.forename: N G
authors.initials: NG
authors.lastname: O'Connor
authors.forename: D N
authors.initials: DN
authors.lastname: Carney
authors.forename: P A
authors.initials: PA
authors.lastname: Dervan
authors.forename: B J
authors.initials: BJ
authors.lastname: Hurson
authors.forename: J T
authors.initials: JT
authors.lastname: Ennis
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents