IL-5 responsive subsets among normal and lymphomatous murine B cells.
Two normal murine B-cell subpopulations, germinal center and coelomic B cells, and at least some of the lymphomas derived from them, respond to IL-5. In the case of normal B cells, a comitogen (DxS) is required. IFN-gamma is strongly inhibitory to proliferation of the coelomic B-cell subset but not for germinal center cells or the SJL lymphomas derived from them.
Tsiagbe
V K
VK
Department of Pathology, New York University Medical School, New York 10016.
Nicknam
M H
MH
Fattah
D
D
Thorbecke
G J
GJ
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D003114:Colony-Forming Units Assay; D007371:Interferon-gamma / Q000494:pharmacology; D015848:Interleukin-5 / Q000494:pharmacology*; D016393:Lymphoma, B-Cell / Q000276:immunology*; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology
D015848:Interleukin-5; D011994:Recombinant Proteins; D007371:Interferon-gamma