title: The role of bradykinin in the etiology of vasogenic brain edema and perilesional brain dysfunction.
abstract: The feline infusion model of brain edema was used to evaluate the role of bradykinin in the etiology and pathophysiology of vasogenic brain edema. Bradykinin (3 or 90 ug in 600 microL saline) did not alter normocapnic regional cerebral blood flow (rCBF) nor induce specific changes in either the somatosensory (SEP) or motor (MEP) evoked potentials. The mean increases in ICP (from 4.5 to 16.1 mmHg) and peri-infusion white matter water content (from 69.4 to 79.8 ml/100 g tissue), mean decrease in lumped craniospinal compliance (from 0.040 to 0.014 ml/mmHg) and local histological changes were all similar to those after 600 microL saline infusion. The interstitial bradykinin infusion caused focal blood-brain-barrier (BBB) opening to Evans Blue dye and was chemotaxic for granulocytes. After the infusion there was a global loss of rCBF CO2 reactivity but there was no ischemia at normocapnia. These results show that bradykinin in brain edema fluid, at concentrations greater than those found in neuropathological conditions, can open the BBB of normal cerebral parenchymal capillaries and cause vascular dysregulation. In neuropathological conditions bradykinin may therefore potentiate formation of vasogenic brain edema but does not contribute to perilesional brain dysfunction.
authors.affiliation: Department of Clinical Neurosciences, Western General Hospital, Edinburgh, Scotland.
authors.forename: I R
authors.initials: IR
authors.lastname: Whittle
authors.forename: I R
authors.initials: IR
authors.lastname: Piper
authors.forename: J D
authors.initials: JD
authors.lastname: Miller
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001920:Bradykinin / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D001929:Brain Edema / Q000503:physiopathology*; D001931:Brain Mapping; D002415:Cats; D002540:Cerebral Cortex / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D007427:Intracranial Pressure / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012039:Regional Blood Flow
chemical_list: D001920:Bradykinin