title: Early endotoxin tolerance in suckling rats.
abstract: Early endotoxin tolerance has not been well investigated in the newborn. This study demonstrated that a sublethal dose of Salmonella enteritidis lipopolysaccharide (S. ent-LPS) or rough mutant Salmonella minnesota LPS (Re-LPS) induced early endotoxin tolerance in suckling rats, showing blunted hypoglycemia and decreased mortality. The mortality of endotoxic shock was lower in S. ent-LPS pretreated group than Re-LPS pretreated group. A sublethal dose of S. ent-LPS caused lactacidemia but Re-LPS did not. Therefore, early endotoxin tolerance appeared to be related to physiologic responses to the initial LPS exposure.
authors.affiliation: Department of Pediatrics, Loyola University of Chicago, Maywood 60153.
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
authors.forename: R
authors.initials: R
authors.lastname: Young
authors.forename: M E
authors.initials: ME
authors.lastname: Gottschalk
authors.forename: C L
authors.initials: CL
authors.lastname: Anderson
authors.forename: W P
authors.initials: WP
authors.lastname: Zeller
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001786:Blood Glucose / Q000378:metabolism; D004731:Endotoxins / Q000633:toxicity*; D007773:Lactates / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012475:Salmonella / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D004731:Endotoxins; D007773:Lactates; D008070:Lipopolysaccharides