title: Capsaicin pretreatment of rats does not prevent tissue extravasation of albumin from intra-abdominal trauma.
abstract: Intra-abdominal surgery causes a loss of plasma into tissues within and around the abdomen, predisposing to a decreased tissue viability and postoperative complications. In a rat model of intra-abdominal trauma, we investigated whether neuropeptides released from thin afferent nerve endings may contribute to this extravasation. Newborn male Wistar rats were pretreated with capsaicin 50 mg/kg s.c., leading to a lifelong degeneration of thin afferents. The same animals, when adult, were subjected to experiments under chloralose anesthesia in which tissue clearances of radiolabelled albumin were determined by a double isotope technique. Non-pretreated animals served as controls. In non-traumatized animals, pretreated rats had a higher loss of labelled albumin in calf muscle. In animals subjected to the standardized intra-abdominal trauma, the pretreatment did not decrease the trauma-induced loss of albumin. In neck skin, the loss of protein was higher in pretreated animals, possibly due to a decreased trauma-induced sympathetic activation. In conclusion, degeneration of thin afferent fibers may alter the autonomic reflex response to intra-abdominal trauma, but neuropeptide release from afferents apparently plays no role in the relocation of albumin.
authors.affiliation: Department of Anesthesiology, Sahlgren's Hospital, Göteborg, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Akerström
authors.forename: B
authors.initials: B
authors.lastname: Lisander
mesh_terms: D000007:Abdominal Injuries / Q000378:metabolism*; D000418:Albumins / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002211:Capsaicin / Q000008:administration & dosage*; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000418:Albumins; D002211:Capsaicin