title: Kainic acid lesion of the striatum increases dopamine release but reduces 3-methoxytyramine level.
abstract: Kainic acid lesion of the striatum leads to the disruption of the striatonigral regulatory loop. Although microdialysis showed an increase in dopamine release, two days after kainic acid injection, 3-methoxytyramine levels are dramatically decreased. This suggests that the postsynaptic membrane-bound catechol-O-methyltransferase (COMT), but not the glial COMT, is responsible for the formation of measured 3-methoxytyramine.
authors.affiliation: Unité de Neuropsychopharmacologie Expérimentale, U.R.A. 1170 du CNRS, Faculté de Médecine et de Pharmacie de Rouen, Saint Etienne du Rouvray, France.
authors.forename: L
authors.initials: L
authors.lastname: Naudon
authors.forename: N
authors.initials: N
authors.lastname: Dourmap
authors.forename: I
authors.initials: I
authors.lastname: Leroux-Nicollet
authors.forename: J
authors.initials: J
authors.lastname: Costentin
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002394:Catechol O-Methyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000502:physiology*; D003956:Dialysis; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism*; D006719:Homovanillic Acid / Q000378:metabolism; D007608:Kainic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D002394:Catechol O-Methyltransferase; C001746:3-methoxytyramine; D007608:Kainic Acid; D004298:Dopamine; D006719:Homovanillic Acid