title: Modifiers of bx1 alter the distribution of Ubx proteins in haltere imaginal discs of Drosophila.
abstract: The bithorax (bx) mutations in the Ultrabithorax (Ubx) gene of Drosophila melanogaster cause homeotic transformations of anterior third thoracic structures (T3a) toward anterior second thoracic structures (T2a) in the adult fly. A corresponding loss of Ubx protein expression in T3a of bx imaginal discs has been observed (White and Wilcox, 1985). We describe two genetic loci which modify the bx-induced transformation. A locus which we map very close to the pink peach (pp) gene suppresses the bx1 phenotype. In contrast, mutations in the suppressor of sable (su(s)) gene enhance the bx1 phenotype. A correlation was observed between patterns of Ubx protein expression and the phenotypic transformations observed.
authors.affiliation: Banting and Best Department of Medical Research, C.H. Best Institute, University of Toronto, Ontario, Canada.
authors.forename: A S
authors.initials: AS
authors.lastname: Manoukian
authors.forename: H M
authors.initials: HM
authors.lastname: Krause
authors.forename: E W
authors.initials: EW
authors.lastname: Larsen
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000502:physiology; D003434:Crossing Over, Genetic; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development; D005260:Female; D014644:Genetic Variation; D018398:Homeodomain Proteins; D010641:Phenotype; D013489:Suppression, Genetic; D013909:Thorax / Q000737:chemistry; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors; C066177:Ubx protein, Drosophila