Lethal effects of normeperidine.
Normeperidine, having a longer half-life than meperidine, can accumulate faster. Its excitatory neurotoxicity is manifest with administration of multiple meperidine doses or in cases of renal failure. This is a report of the lethal effects of normeperidine in a patient with renal failure who had abused meperidine.
Jiraki
K
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Cuyahoga County Coroner's Office, Cleveland, OH 44106.
D000328:Adult; D002800:Cholinesterase Inhibitors / Q000493:pharmacokinetics / Q000506:poisoning*; D006207:Half-Life; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000209:etiology; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000506:poisoning; D019966:Substance-Related Disorders / Q000150:complications*
D002800:Cholinesterase Inhibitors; D008614:Meperidine; C002752:normeperidine