[Horton's disease with involvement of the arterial trunks of the arms. Pathogenic role of anticardiolipin antibodies? Report of two cases].
Diffuse arterial involvement in temporal arteritis is well known but the intimate mechanisms of vasculopathy is unknown. Recently the presence of anticardiolipin antibodies (aCL) has been recognized in giant cell arteritis. We report two cases of temporal arteritis with diffuse arterial involvement associated with aCL (axillary arteries in the two cases associated with femoral arteries in one). During corticosteroid and anticoagulant therapy, a rapid improvement was noted with regression of upper-limb ischemia. One month later, the aCL were absent. These cases confirm the presence of aCL in giant cell arteritis with diffuse arterial involvement. These antibodies might imply severe vascular damage and could play a role in pathogenesis of the vasculopathy of temporal arteritis. Their presence suggests the necessity of anticoagulant therapy at the beginning of corticosteroid therapy.
Cailleux
N
N
Service de Médecine Interne, Angéiologie, Diabétologie, CHU Rouen-Boisguillaume.
Lévesque
H
H
Borg
J Y
JY
Clavier
E
E
Courtois
H
H
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000925:Anticoagulants / Q000627:therapeutic use; D001132:Arm / Q000098:blood supply*; D001158:Arteries; D002308:Cardiolipins / Q000276:immunology*; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D002308:Cardiolipins
Maladie de Horton avec atteinte des troncs artériels des membres supérieurs. Rôle pathogène des anticorps anticardiolipine? A propos de deux observations.