title: Effects of phosphatidylserine in Alzheimer's disease.
abstract: We studied 51 patients meeting clinical criteria for probable Alzheimer's disease (AD). Patients were treated for 12 weeks with a formulation of bovine cortex phosphatidylserine (BC-PS; 100 mg t.i.d.) or placebo, and those treated with the drug improved on several cognitive measures relative to those administered placebo. Differences between treatment groups were most apparent among patients with less severe cognitive impairment. Results suggest that phosphatidylserine may be a promising candidate for study in the early stages of AD.
authors.affiliation: Memory Assessment Clinics, Inc., Bethesda, MD 20814.
authors.forename: T
authors.initials: T
authors.lastname: Crook
authors.forename: W
authors.initials: W
authors.lastname: Petrie
authors.forename: C
authors.initials: C
authors.lastname: Wells
authors.forename: D C
authors.initials: DC
authors.lastname: Massari
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010718:Phosphatidylserines / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D010718:Phosphatidylserines