Hypomagnesaemia-induced hypocalcaemia: concentrations of parathyroid hormone, prolactin and 1,25-dihydroxyvitamin D during magnesium replenishment.
Three patients with hypomagnesaemia-induced hypocalcaemia were investigated during the phase of magnesium replenishment. Before treatment, serum levels of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were at the lower limit of normal. In spite of a rapid rise of parathyroid hormone (PTH) after intravenous administration of magnesium, a reactive increase in 1,25-dihydroxyvitamin D in serum was absent or delayed. The increase of serum calcium into the normal range occurred before any consistent change in the concentrations of this vitamin D metabolite. The rise of serum prolactin in response to the increase in PTH was blunted or absent, and is a further example of a transient PTH resistance during the phase of magnesium replenishment.
Leicht
E
E
Medizinische Klinik, Universität des Saarlandes, Homburg/Saar, Germany.
Schmidt-Gayk
H
H
Langer
H J
HJ
Sneige
N
N
Biro
G
G
D000437:Alcoholism / Q000097:blood / Q000150:complications; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood*; D003424:Crohn Disease / Q000097:blood / Q000150:complications / Q000601:surgery; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000209:etiology*; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use*; D008275:Magnesium Deficiency / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D010281:Parathyroid Hormone / Q000097:blood* / Q000378:metabolism; D011388:Prolactin / Q000097:blood*; D012778:Short Bowel Syndrome / Q000097:blood
D010281:Parathyroid Hormone; D011388:Prolactin; D002117:Calcitriol; D008274:Magnesium; D002112:Calcifediol