A study of the stability of W/O/W multiple emulsions.
The stability of W/O/W emulsions has been studied in batch agitators. The surfactants suitable for W/O/W emulsions were screened and the factors affecting the emulsion stability were also studied. Results showed that polyamine E644 was an excellent emulsifier for W/O emulsions since the emulsion stabilized by it has not only good stability but also shows smaller swelling. The stability of the emulsion increases with increase in membrane viscosity and concentration of surfactant, but decreases with increase in concentration of the internal reagent in the internal phase and the carriers in the membrane. Raising the agitation speed and the time for preparing the W/O emulsion is beneficial to membrane stability due to formation of smaller internal droplets, but raising the speed for dispersing the W/O emulsion in the external phase results in an increase in membrane breakage.
Yan
N
N
Department of Chemical Engineering, Suzhou University, China.
Zhang
M
M
Ni
P
P
D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000737:chemistry; D007648:Kerosene; D008566:Membranes; D009821:Oils / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors; D014783:Viscosity; D014867:Water / Q000737:chemistry*
D004337:Drug Carriers; D004655:Emulsions; D007202:Indicators and Reagents; D007648:Kerosene; D009821:Oils; D013501:Surface-Active Agents; D014867:Water; D012964:Sodium