Helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion.
The effect of Helicobacter pylori lipopolysaccharide on guinea pig gastric mucosal pepsinogen secretion has been examined using an Ussing chamber technique. Luminal addition of H. pylori lipopolysaccharide resulted in a fifty-fold stimulation of pepsinogen secretion compared to a twelve-fold increase with E. coli lipopolysaccharide. Electron microscopy showed marked degranulation of zymogen granules but no evidence of chief cell disruption.
Young
G O
GO
Gastrointestinal Clinic, Department of Medicine, University of Cape Town, South Africa.
Stemmet
N
N
Lastovica
A
A
van der Merwe
E L
EL
Louw
J A
JA
Modlin
I M
IM
Marks
I N
IN
D000818:Animals; D004926:Escherichia coli; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D016480:Helicobacter pylori; D066298:In Vitro Techniques; D008070:Lipopolysaccharides; D008564:Membrane Potentials / Q000502:physiology; D008853:Microscopy; D010435:Pepsinogens / Q000378:metabolism*; D013268:Stimulation, Chemical
D008070:Lipopolysaccharides; D010435:Pepsinogens