Lack of evidence for perfluorodecanoyl- or perfluorooctanoyl-coenzyme A formation in male and female rats.
Perfluorodecanoic (PFDA) and perfluorooctanoic (PFOA) acids belong to the structurally diverse group of compounds known to cause peroxisomal proliferation. It has been hypothesized that the common mode of action of these compounds is that they act through an activated coenzyme A (CoA) thioester. Using rat liver microsomal and isolated rat hepatocyte incubation conditions that were effective in producing a CoA conjugate of clofibric acid, no corresponding CoA derivative could be found for either PFDA or PFOA.
Kuslikis
B I
BI
School of Pharmacy, University of Wisconsin, Madison 53706.
Vanden Heuvel
J P
JP
Peterson
R E
RE
D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D002210:Caprylates / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002995:Clofibric Acid / Q000031:analogs & derivatives / Q000378:metabolism; D003065:Coenzyme A / Q000378:metabolism*; D003652:Decanoic Acids / Q000378:metabolism*; D005260:Female; D005466:Fluorocarbons / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D000214:Acyl Coenzyme A; D002210:Caprylates; D003652:Decanoic Acids; D005466:Fluorocarbons; C051513:clofibric acid-coenzyme A; C036567:perfluorodecanoic acid; D002995:Clofibric Acid; C023036:perfluorooctanoic acid; D003065:Coenzyme A