Tumor suppressor genes in the cell cycle.
In the past year, two tumor suppressor genes, retinoblastoma and p53, have been established as important players in cell-cycle control, mediated by phosphorylation and by stage-specific transcription complexes. Evidence that they also participate in other transcription complexes is accumulating and searches are underway for the downstream genes under their regulation. Genes down-regulated in tumor cells are being screened by subtractive hybridization to bridge the gap between transcription factors and their targets.
Sager
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Dana-Farber Cancer Institute, Boston, Massachusetts.
D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D016161:Genes, Retinoblastoma; D016147:Genes, Tumor Suppressor; D006801:Humans; D016160:Retinoblastoma Protein / Q000502:physiology; D012641:Selection, Genetic
D016160:Retinoblastoma Protein