title: Changes in surface antigens on preimplantation mouse embryos.
abstract: Changes in the expression of specific cell surface antigens on preimplantation mouse embryos were examined by immunocytochemistry. Embryos were recovered at various times during the preimplantation phase of normal pregnancy, and from pregnancies with experimentally induced delayed implantation, and were probed with a panel of monoclonal antibodies against murine leukocyte antigens. Antibodies directed against certain macrophage surface glycoproteins (i.e., Mac-2 and Mac-3) and those against lysosome-associated membrane glycoproteins (i.e., LAMP-1 and LAMP-2) reacted specifically with cell surface determinants on the embryos. Differences in the spatiotemporal patterns of antibody binding during normal and delayed implantation indicate that expression of the antigenic determinants recognized by these antibodies is regulated individually in response to intrinsic as well as extrinsic signals at the time of implantation, and thus they may be important for the process of embryo implantation.
authors.affiliation: Department of Cell Biology, Texas Tech University Health Sciences Center, Lubbock 79430.
authors.forename: H M
authors.initials: HM
authors.lastname: Weitlauf
authors.forename: K A
authors.initials: KA
authors.lastname: Knisley
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D001755:Blastocyst / Q000276:immunology*; D010064:Embryo Implantation / Q000276:immunology; D010065:Embryo Implantation, Delayed / Q000276:immunology; D005260:Female; D037502:Galectin 3; D007150:Immunohistochemistry; D051907:Lysosomal Membrane Proteins; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D011247:Pregnancy
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000943:Antigens, Differentiation; D000954:Antigens, Surface; D037502:Galectin 3; D051907:Lysosomal Membrane Proteins; D008562:Membrane Glycoproteins