title: [Prognostic factors of radically operated stage Ib cervix cancer].
abstract: The present retrospective study attempts to evaluate the significance of factors such as age, histological type, histological grading, tumour size, lymph node metastases and tumour infiltration of the corpus uteri. Between 1975 and 1988, 312 patients were operated at our department or referred to postoperative radiotherapy. They fulfilled the inclusion criteria: histopathological stage Ib and radical hysterectomy with pelvic lymphadenectomy. The multivariate analysis confirmed, that the factors histological grading (G3 vs G1 + G2: relative risk (RR) = 2.66; 95% confidence interval (CI) = 1.36-5.18), tumour size (tumour infiltration of the cervix greater than 2/3 vs less than 2/3: RR = 2.36; 95% CI = 1.07-5.17), and pelvic lymph node metastases (positive vs negative: RR = 5.36; 95% CI = 2.70-10.65) are of significant importance for the survival. The results show, that patients with a cervical carcinoma in FIGO stage IB, with an infiltration of more than two thirds of the cervix with a more or less differentiation and with or without positive lymph node status, should be classified as high risk patients. In these unfavourable situations, a prospective randomised study should clarify the success rate of adjuvant therapy.
authors.affiliation: I. Universitäts Frauenklinik Wien.
authors.forename: N
authors.initials: N
authors.lastname: Vavra
authors.forename: H
authors.initials: H
authors.lastname: Kucera
authors.forename: W
authors.initials: W
authors.lastname: Eppel
authors.forename: M
authors.initials: M
authors.lastname: Barrada
authors.forename: H
authors.initials: H
authors.lastname: Salzer
authors.forename: M
authors.initials: M
authors.lastname: Schemper
authors.forename: P
authors.initials: P
authors.lastname: Sevelda
mesh_terms: D000328:Adult; D001918:Brachytherapy; D002584:Cervix Uteri / Q000473:pathology; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D011867:Radioisotope Teletherapy; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*
chemical_list: D003037:Cobalt Radioisotopes
vernacular_title: Prognosefaktoren des radikal operierten Zervixkarzinoms im Stadium Ib.