title: Intermittent micromotion inhibits bone ingrowth. Titanium implants in rabbits.
abstract: We studied the effects of micromotion on bone ingrowth into a 1-mm canal through a titanium chamber implanted in the proximal tibia of rabbits. The implant surface became "osseointegrated," but an interior core was movable, allowing the central portion of the canal to be moved in relation to the ends. Thus, the ingrowing bone in the canal had to pass an area of ad latus motion. When implanted in rabbit tibiae, the canal became filled with ingrown cancellous bone. Bone ingrowth was inhibited by 20 cycles of 0.5-mm movement applied during a 30-second period once daily. With this regimen, the canal was usually filled with vascularized fibrous tissue and significantly less bone. The micromotion chamber may enable detailed studies of the effects of different motion variables on ingrowth of bone.
authors.affiliation: Department of Orthopedics, University Hospital, Lund, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Aspenberg
authors.forename: S
authors.initials: S
authors.lastname: Goodman
authors.forename: S
authors.initials: S
authors.lastname: Toksvig-Larsen
authors.forename: L
authors.initials: L
authors.lastname: Ryd
authors.forename: T
authors.initials: T
authors.lastname: Albrektsson
mesh_terms: D000497:Alloys; D000818:Animals; D001846:Bone Development; D009038:Motion; D016348:Osseointegration; D019736:Prostheses and Implants; D011817:Rabbits; D013977:Tibia / Q000378:metabolism* / Q000601:surgery; D014025:Titanium
chemical_list: D000497:Alloys; C031462:titanium alloy (TiAl6V4); D014025:Titanium