Utilization of pulse oximetry for the study of the inhibitory effects of antiviral agents on influenza virus in mice.
Pulmonary disease in mice induced by influenza virus was monitored by measurement of oxygen saturation (SaO2) in blood with a pulse oximeter. The SaO2 declined in inverse proportion to the viral inoculum. The known antiviral agent ribavirin inhibited the SaO2 decline, prevented death, lowered lung consolidation, and reduced the level of recoverable virus. Pulse oximetry is an effective means of monitoring murine influenzal disease and can be used in the study of potential antiviral drugs.
Sidwell
R W
RW
Institute for Antiviral Research, Utah State University, Logan 84322-5600.
Huffman
J H
JH
Gilbert
J
J
Moscon
B
B
Pedersen
G
G
Burger
R
R
Warren
R P
RP
D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D009980:Influenza A virus; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood; D012254:Ribavirin / Q000627:therapeutic use
D000998:Antiviral Agents; D012254:Ribavirin; D010100:Oxygen