title: Translocation (6;16) in a case of granulosa cell tumor of the ovary.
abstract: We performed a cytogenetic study of an ovarian granulosa cell tumor (GCT). Tumor cells showed a translocation (6;16); the full karyotype was 45,XX-6,dic(6;16)(q11;q22)/44,XX,-6,-22,dic(6;16)(q11;q22),-22/46,XX,- 6,dic(6;16)(q11;q22), +dic(6;16)(q11;q22). This is the second case of GCT with structural changes of chromosome 6 leading to loss of 6q material.
authors.affiliation: Department of Pathology and Gynecology, Erasme Hospital, Free University of Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Verhest
authors.forename: B
authors.initials: B
authors.lastname: Nedoszytko
authors.forename: J C
authors.initials: JC
authors.lastname: Noel
authors.forename: J M
authors.initials: JM
authors.lastname: Dangou
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Limon
mesh_terms: D000328:Adult; D002885:Chromosomes, Human, Pair 16; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006106:Granulosa Cell Tumor / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic