Antinociceptive properties of thiamine, pyridoxine and cyanocobalamin following repeated oral administration to mice.
Following repeated oral administration for 7 days thiamine (thiamine nitrate, CAS 532-43-4), pyridoxine (pyridoxol hydrochloride, CAS 58-56-0), and cyanocobalamin (CAS 68-19-9) exhibited at high dose levels alone or in combination dose-related antinociceptive properties in the writhing test in the mouse. Cyanocobalamin exerted a potentiating effect in the combination of the 3 vitamins.
Leuschner
J
J
LPT-Laboratory of Pharmacology and Toxicology, Hamburg, Fed. Rep. of Germany.
D000284:Administration, Oral; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D005260:Female; D051379:Mice; D010147:Pain Measurement; D011736:Pyridoxine / Q000494:pharmacology / Q000633:toxicity; D013831:Thiamine / Q000494:pharmacology / Q000633:toxicity; D014805:Vitamin B 12 / Q000494:pharmacology / Q000633:toxicity; D014803:Vitamin B Complex / Q000494:pharmacology* / Q000633:toxicity
D000700:Analgesics; D014803:Vitamin B Complex; D011736:Pyridoxine; D014805:Vitamin B 12; D013831:Thiamine