title: [Arthropathy due to hemochromatosis: often inaugural manifestation of the disease].
abstract: Idiopathic hemochromatosis is a recessive autosomal disorder of iron metabolism manifested by a tissue overload affecting many organs, including the liver, the heart, the endocrine glands and the joints. Of 53 patients we studied, 66% had articular symptoms (mainly arthralgias of the metacarpophalangeal joints) and 49% had radiological lesions such as chondrocalcinosis and structural joint damage. The radiological signs were slightly more frequent in women (56.3%) than men (45.9%). Mean age at diagnosis was moderately higher in the group with arthropathy (52 years) than in the group without (44 years). Analysis of clinical, radiological and biological data, including parathormone values, did not reveal other parameters differentiating the two groups. A family study does not support the hypothesis of double heredity for hemochromatosis and arthropathy. In 20% of the patients the arthropathy was the inaugural feature of the hemochromatosis. The interval between first symptoms and diagnosis for these patients (5.3 years on average) is unfortunately long. Determination of transferrin saturation allows early diagnosis.
authors.affiliation: Département de médecine, Hôpital cantonal universitaire, Genève.
authors.forename: P
authors.initials: P
authors.lastname: Aellen
authors.forename: P A
authors.initials: PA
authors.lastname: Guerne
authors.forename: D
authors.initials: D
authors.lastname: Zenagui
authors.forename: T L
authors.initials: TL
authors.lastname: Vischer
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006432:Hemochromatosis / Q000097:blood / Q000150:complications*; D006801:Humans; D007592:Joint Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D008111:Liver Function Tests; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D011859:Radiography; D014168:Transferrin / Q000032:analysis
chemical_list: D014168:Transferrin
vernacular_title: L'arthropathie de l'hémochromatose: manifestation souvent inaugurale de la maladie.