title: Modulation of daily water intake by dopamine in caudate and accumbens nuclei in rats.
abstract: Bilateral lesions of accumbens and caudate nuclei resulted in significant and sustained increase in water intake. Administration of different doses of dopamine (DA) into these nuclei facilitated a dose-dependent increase in 24-h water intake, whereas injection of spiperone following administration of DA inhibited DA-facilitated water intake in a dose-dependent manner. Conversely, administration of DA and spiperone did not elicit any change in water intake in septal nuclei; rather septal lesion facilitated the water intake. This suggests that the nucleus accumbens and nucleus caudatus act as facilitatory thirst areas and that DA is a possible dipsogenic neurotransmitter in these nuclei. This also suggests that the nucleus septal lateralis is a thirst-inhibiting centre where DA may not be involved in dipsogenesis.
authors.affiliation: Department of Physiology, Jawaharlal Institute of Post-Graduate, Medical Education and Research, Pondicherry, India.
authors.forename: G K
authors.initials: GK
authors.lastname: Pal
authors.forename: B
authors.initials: B
authors.lastname: Bharathi
authors.forename: D P
authors.initials: DP
authors.lastname: Thombre
mesh_terms: D000818:Animals; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D004326:Drinking / Q000502:physiology*; D005260:Female; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology*; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*
chemical_list: D011954:Receptors, Dopamine; D004298:Dopamine