Simultaneous study of the biodistribution of radio-yttrium complexed with EDTMP and citrate ligands in tumour-bearing rats.
The influence of the ligands ethylenediaminetetramethylene phosphonic acid (EDTMP) and citrate (CIT) on the biodistribution of radio-yttrium in rats bearing a DS-carcinosarcoma was compared. 88Y-EDTMP and 87Y-CIT were i.v. injected into the same animals. Faster blood clearance and higher renal excretion were observed for the EDTMP-ligand. Of high practical interest is the reduced liver uptake of radio-yttrium (by one order of magnitude) with the EDTMP complex. Since bone and tumour accumulation is only weakly influenced, high tumour-to-liver ratios (up to 14) were observed. We propose to use EDTMP or similar complex ligands for liver blocking when radionuclides like 90Y, 169Yb, 225Ac or other group 3 elements are to be applied in endoradionuclide therapy technique.
Beyer
G J
GJ
Central Institute of Nuclear Research, Rossendorf, RI Department, Dresden, Fed. Rep. Germany.
Bergmann
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R
Kampf
G
G
Mäding
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P
Rösch
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F
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002296:Carcinosarcoma / Q000378:metabolism*; D002951:Citrates / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D009943:Organophosphorus Compounds / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D015021:Yttrium Radioisotopes / Q000493:pharmacokinetics
D002951:Citrates; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D015021:Yttrium Radioisotopes; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid; C045937:yttrium citrate