title: Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion.
abstract: The use of aerosolized gadopentetate dimeglumine to define regional lung ventilation and of intravenously administered polylysine-(gadopentetate dimeglumine)40 to assess regional lung perfusion was investigated. In 10 healthy rats who breathed aerosolized gadopentetate dimeglumine (0.25 mol/L) for 5 minutes, pulmonary signal intensity increased diffusely in both lungs by more than 70%. When the same animals received intravenously administered polylysine-(gadopentetate dimeglumine)40 (0.1 mmol of gadolinium per kilogram), there was an additional 300% enhancement of the pulmonary parenchyma. In a rat model of acute unilateral pulmonary embolism (n = 5), perfusion defects were identified after administration of polylysine-(gadopentetate dimeglumine)40, but no ventilation abnormality was seen after inhalation of gadopentetate dimeglumine. In a rat model of acute unilateral airway obstruction (n = 5), only the ventilated right lung enhanced after inhalation of gadopentetate dimeglumine. In four of these animals, the focal ventilation defect was accompanied by a matched decrease in perfusion, seen after enhancement of the blood pool with polylysine-(gadopentetate dimeglumine)40.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143-0628.
authors.forename: Y
authors.initials: Y
authors.lastname: Berthezène
authors.forename: V
authors.initials: V
authors.lastname: Vexler
authors.forename: O
authors.initials: O
authors.lastname: Clément
authors.forename: A
authors.initials: A
authors.lastname: Mühler
authors.forename: M E
authors.initials: ME
authors.lastname: Moseley
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
mesh_terms: D000336:Aerosols; D000402:Airway Obstruction / Q000175:diagnosis / Q000503:physiopathology; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D019786:Gadolinium DTPA; D008168:Lung / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000008:administration & dosage; D004369:Pentetic Acid / Q000008:administration & dosage; D011107:Polylysine / Q000008:administration & dosage / Q000031:analogs & derivatives; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D014692:Ventilation-Perfusion Ratio
chemical_list: D000336:Aerosols; D003287:Contrast Media; D009942:Organometallic Compounds; C068674:polylysine-(Gd-DTPA); D011107:Polylysine; D004369:Pentetic Acid; D019786:Gadolinium DTPA