title: Sirenomelia accompanying exposure of the embryo to cocaine.
abstract: We have reported two cases of sirenomelia sequence associated with a history of cocaine exposure during a major part or the entire extent of the first trimester of pregnancy. The two infants were delivered during a 2 1/2-year interval in a newborn population in which prenatal cocaine exposure rose to an estimated 25%. The incidence of sirenomelia in this population was 18-fold higher than previously reported. The potential relationship between sirenomelia and cocaine exposure during the first month of pregnancy warrants further investigation.
authors.affiliation: Department of Pediatrics and Child Health, Howard University College of Medicine, Washington, DC 20059.
authors.forename: S
authors.initials: S
authors.lastname: Sarpong
authors.forename: V
authors.initials: V
authors.lastname: Headings
mesh_terms: D000328:Adult; D003042:Cocaine; D004480:Ectromelia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011859:Radiography; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D003042:Cocaine