Inhibition of pigeon breast muscle alpha-ketoglutarate dehydrogenase by phosphonate analogues of alpha-ketoglutarate.
Succinylphosphonate (SP) is a powerful inhibitor of alpha-ketoglutarate dehydrogenase (KGD). Methylation of the phosphonate reduces its inhibitory effect. The complex of KGD with SP undergoes a kinetically slow transition similar to the process observed during catalysis. alpha-Ketoglutarate binds to the enzyme-inhibitor complex, preventing its isomerisation.
Bunik
V I
VI
Department of Biochemistry, Moscow State University, Russia.
Biryukov
A I
AI
Zhukov YuN
D000818:Animals; D010856:Columbidae; D007655:Ketoglutarate Dehydrogenase Complex / Q000037:antagonists & inhibitors*; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D007700:Kinetics; D008745:Methylation; D009132:Muscles / Q000201:enzymology*; D063065:Organophosphonates / Q000494:pharmacology*
D007656:Ketoglutaric Acids; D063065:Organophosphonates; D007655:Ketoglutarate Dehydrogenase Complex