Toxicities of the nonsteroidal anti-inflammatory drugs.
There has been significant progress in defining the risks associated with the use of nonsteroidal anti-inflammatory drugs. There is now clear consensus that certain patient subsets are at an increased risk for gastroduodenal mucosal damage when those patients are treated with these drugs. The therapy for treating mucosal damage or preventing it has also been better defined. The studies published this year have provided a better understanding of those patients who should be considered as candidates for possible therapy for prophylaxis against mucosal damage and which drugs might be useful. The patients who are at risk to develop renal dysfunction remain less well defined. This paper reviews the current relevant literature.
Simon
L S
LS
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D004064:Digestive System / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D012216:Rheumatic Diseases / Q000188:drug therapy / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal