Application of derivative resolution of UV spectra to the quality control of rifaximine and its possible impurities.
An UV spectrophotometric method with derivative resolution was developed for the analysis of rifaximine (a synthetic rifamycin) in the presence of potential impurities of synthesis and oxidation. The method was particularly suitable for the qualitative identification of the set of compounds and had good detection limits.
Corti
P
P
Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Italia.
Savini
L
L
Celesti
L
L
Ceramelli
G
G
Montecchi
L
L
D004340:Drug Contamination; D011786:Quality Control; D012294:Rifamycins / Q000032:analysis*; D000078262:Rifaximin; D013056:Spectrophotometry, Ultraviolet
D012294:Rifamycins; D000078262:Rifaximin