title: Long-term results of iodine 125 irradiation of uveal melanoma.
abstract: The authors report on 64 of the first 65 patients treated with iodine 125. The mean follow-up was 64.9 months. After treatment, 29 patients (45.3%) retained visual acuity of 20/100 or better, and 18 patients (28.1%) retained visual acuity within two lines of visual acuity before irradiation. Eleven patients (17.2%) died of metastasis, and 5 patients (7.8%) had local recurrence. Cataract developed in 29 (45.3%) patients; keratitis developed in only 2 (3.1%) patients, and dry eye developed in none. Neovascular glaucoma developed in 7 (10.9%) patients, and 15 (23.4%) patients had radiation retinopathy. Eleven patients (17.2%) required enucleation for either tumor growth or neovascular glaucoma. These results show the increasing number of radiation complications seen with long-term observation and the frequently seen adverse visual outcome.
authors.affiliation: Department of Ophthalmology, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.
authors.forename: S
authors.initials: S
authors.lastname: Packer
authors.forename: S
authors.initials: S
authors.lastname: Stoller
authors.forename: M L
authors.initials: ML
authors.lastname: Lesser
authors.forename: F S
authors.initials: FS
authors.lastname: Mandel
authors.forename: P T
authors.initials: PT
authors.lastname: Finger
mesh_terms: D001918:Brachytherapy / Q000009:adverse effects; D002830:Choroid Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008137:Longitudinal Studies; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity
chemical_list: D007457:Iodine Radioisotopes