Locomotor activity but not conditioned place preference is differentially affected by a moderate dose of ethanol administered to P and NP rats.
The conditioned place preference (CPP) test and spontaneous motor activity were used in order to determine if ethanol-preferring (P) rats differ from ethanol nonpreferring (NP) rats after the administration of a moderate (1.0 g/kg) dose of ethanol. Results indicate that both of the selectively bred lines of rats found ethanol aversive, with little difference between the P and the NP rats. In contrast, the NP rats were shown to be more sensitive to the motor-impairing effect of ethanol.
Schechter
M D
MD
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
D000428:Alcohol Drinking; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004777:Environment; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011922:Rats, Mutant Strains; D012054:Reinforcement, Psychology
D000431:Ethanol