title: Base-of-tongue cancer treated with external beam irradiation plus brachytherapy: oncologic and functional outcome.
abstract: Between January 1981 and June 1990, 36 previously untreated patients with squamous cancer of the base of the tongue were treated with radiation therapy. This therapy consisted of a 5,000-5,400-cGy external beam plus a 2,000-3,000-cGy boost to the base of the tongue with an iridium-192 implant. Necks with negative nodes were only irradiated, while necks with positive nodes were treated with irradiation plus neck dissection. Actuarial local control and survival at 2 years were 87.5%. Neck control was achieved in 35 of 36 patients. When implantation was performed with the nonlooping technique, the injury rate was statistically higher than in patients who underwent implantation with the looping technique (P = .02). Thirty patients participated in a function assessment involving a Performance Status Scale for patients with head and neck cancer. The authors concluded that management of base-of-tongue cancer with external beam irradiation plus brachytherapy is both oncologically and functionally successful.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
authors.forename: L B
authors.initials: LB
authors.lastname: Harrison
authors.forename: M J
authors.initials: MJ
authors.lastname: Zelefsky
authors.forename: R B
authors.initials: RB
authors.lastname: Sessions
authors.forename: D E
authors.initials: DE
authors.lastname: Fass
authors.forename: J G
authors.initials: JG
authors.lastname: Armstrong
authors.forename: D G
authors.initials: DG
authors.lastname: Pfister
authors.forename: E W
authors.initials: EW
authors.lastname: Strong
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000008:administration & dosage; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011879:Radiotherapy Dosage; D013997:Time Factors; D014062:Tongue Neoplasms / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D007496:Iridium Radioisotopes