title: Preparation of poly (D,L) lactide microspheres by emulsion-solvent evaporation, and their clinical applications as a convenient embolic material.
abstract: The aim of preoperative embolization is to facilitate surgical removal by reducing tumor volume and vascularity, thereby decreasing blood loss during surgery. In a search for a better embolic material, compared to heterogeneous commercial products, we describe here in detail the preparation of poly (D,L) lactide microspheres by an emulsion-solvent evaporation process. The size distribution of the microparticles and their aggregation state--critical parameters in view of such application--have been investigated. Their effectiveness, as an embolic material, has been evaluated by some preliminary experiments undertaken on humans. The results were assessed on clinical and histological grounds.
authors.affiliation: Department of Macromolecular Chemistry and Organic Catalysis, University of Liège, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Grandfils
authors.forename: P
authors.initials: P
authors.lastname: Flandroy
authors.forename: N
authors.initials: N
authors.lastname: Nihant
authors.forename: S
authors.initials: S
authors.lastname: Barbette
authors.forename: R
authors.initials: R
authors.lastname: Jérome
authors.forename: P
authors.initials: P
authors.lastname: Teyssié
authors.forename: A
authors.initials: A
authors.lastname: Thibaut
mesh_terms: D004621:Embolization, Therapeutic; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008863:Microspheres; D011091:Polyesters
chemical_list: D011091:Polyesters; C033616:poly(lactide)