Bradykinin modulation of the hydroosmotic effect of the antidiuretic hormone in water-transporting epithelia.
Rocha e Silva's utmost contribution to science was the isolation of bradykinin, a naturally occurring nonapeptide known to have a broad spectrum of actions. Amongst them, considerable evidence suggests that the diuretic effects of endogenous bradykinin are, in part, mediated by inhibition of vasopressin-stimulated water transport. This is true for both the mammalian renal cortical collecting tubule and the urinary bladder of the toad (functionally analogous to the tubule). A review of the main contributions that led to that knowledge is presented.
Furtado
M R
MR
Laboratory of Kidney and Biomembranes, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
D000818:Animals; D001692:Biological Transport; D001834:Body Water / Q000378:metabolism*; D001920:Bradykinin / Q000502:physiology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009994:Osmolar Concentration; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D001920:Bradykinin