New chromosomal abnormality. t(1;19;?) in a case of B-chronic lymphocytic leukemia.
Cytogenetic analysis was performed on peripheral blood cells stimulated with interleukin 6 (IL-6), lipopolysaccharide from Escherichia coli (LPS), phytohemagglutinin (PHA), pokeweed mitogen (PWM) and tetradecanoyl-phorbol-acetate (TPA), in a patient with B-chronic lymphocytic leukemia, showing a t(1;19;?) translocation as the sole abnormality. To our knowledge, this translocation has not been described before in any human neoplasia. In this case, the poor response to therapy (survival time 4 months) suggested that t(1;19;?) could be related to an aggressive course of the disease.
Montero
S
S
Department of Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, Spain.
Caballín
M R
MR
Coll
M D
MD
Besses
C
C
Woessner
S
S
Egozcue
J
J
Solé
F
F
D000368:Aged; D000369:Aged, 80 and over; D002699:Chlorambucil / Q000627:therapeutic use; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D005260:Female; D006801:Humans; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy / Q000235:genetics*; D011241:Prednisone / Q000627:therapeutic use; D014178:Translocation, Genetic / Q000235:genetics*; D014407:Tumor Cells, Cultured
D002699:Chlorambucil; D011241:Prednisone