title: Relationship of age at menarche and subsequent fertility.
abstract: We investigated retrospectively the relationship between the age at menarche and reproductive ability in 2278 married women. Those who had a pregnancy experienced menarche at a mean age (+/- SEM) of 13.7 +/- 0.1 years, and those who were infertile had menarche at a mean age of 14.0 +/- 0.2 years, difference in the times of onset of menarche being significant (P less than 0.05). Moreover, a group in whom menstruation started after the age of 18 years had a significantly higher rate of infertility (15.7%) than the others (5.0%). Irregular menstruations during the first few years after menarche was also related to decreased reproductive ability. These findings indicate the importance of menarche before the age of 18 for normal reproductive functioning.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Komura
authors.forename: A
authors.initials: A
authors.lastname: Miyake
authors.forename: C F
authors.initials: CF
authors.lastname: Chen
authors.forename: O
authors.initials: O
authors.lastname: Tanizawa
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000209:etiology*; D008572:Menarche / Q000502:physiology*; D008598:Menstruation / Q000502:physiology; D008599:Menstruation Disturbances / Q000150:complications; D008875:Middle Aged; D011247:Pregnancy / Q000502:physiology*; D012189:Retrospective Studies