title: Risk of second brain tumour after conservative surgery and radiotherapy for pituitary adenoma.
abstract: OBJECTIVE
  To assess the risk of second brain tumour in patients with pituitary adenoma treated with conservative surgery and external beam radiotherapy.
  
  
  METHODS
  Long term follow up of a cohort of patients with pituitary adenoma and comparison of tumour occurrence with population incidence rates.
  
  
  METHODS
  The Royal Marsden Hospital.
  
  
  METHODS
  334 patients with pituitary adenoma treated with conservative surgery and radiotherapy (median dose 45 Gy) and followed up for 3760 person years.
  
  
  METHODS
  Second intracranial tumour and systemic malignancy.
  
  
  RESULTS
  Five patients developed a second brain tumour: two had astrocytoma, two meningioma, and one meningeal sarcoma. The cumulative risk of developing a second brain tumour over the first 10 years after treatment was 1.3% (95% confidence interval 0.4% to 3.9%) and over 20 years 1.9% (0.7% to 5.0%). The relative risk of a second brain tumour compared with the incidence in the normal population was 9.38 (3.05 to 21.89). There was no excess risk of any other type of second primary malignancy.
  
  
  CONCLUSIONS
  There is an increased risk of second intracranial tumour in patients with pituitary adenoma treated with surgery and radiotherapy. Although radiation is likely to be the most important factor contributing to the excess risk, further study is required in a cohort of similar patients not receiving radiation.
authors.affiliation: Institute of Cancer Research, Sutton, Surrey.
authors.forename: M
authors.initials: M
authors.lastname: Brada
authors.forename: D
authors.initials: D
authors.lastname: Ford
authors.forename: S
authors.initials: S
authors.lastname: Ashley
authors.forename: J M
authors.initials: JM
authors.lastname: Bliss
authors.forename: S
authors.initials: S
authors.lastname: Crowley
authors.forename: M
authors.initials: M
authors.lastname: Mason
authors.forename: B
authors.initials: B
authors.lastname: Rajan
authors.forename: D
authors.initials: D
authors.lastname: Traish
mesh_terms: D000236:Adenoma / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000209:etiology*; D001932:Brain Neoplasms / Q000209:etiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008577:Meningeal Neoplasms / Q000209:etiology*; D008579:Meningioma / Q000209:etiology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology*; D010911:Pituitary Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011183:Postoperative Complications; D011878:Radiotherapy / Q000009:adverse effects; D012306:Risk; D012307:Risk Factors