Nonpregnant women with a history of habitual abortion have normal and luteal function independent production of prostacyclin and thromboxane A2.
OBJECTIVE
To see if changes in prostacyclin and thromboxane A2 (TXA2) production during early pregnancy in women with habitual abortion is a pregnancy-induced change, we compared the production of these prostanoids in habitual aborters and in healthy controls in nonpregnant state and related it to luteal function.


METHODS
Comparison between patients (n = 16) with a history of at least three consecutive miscarriages and healthy controls without a history of abortions (n = 11).


METHODS
Departments I and II of Obstetrics and Gynecology, University Central Hospital of Helsinki, Helsinki, Finland.


RESULTS
Habitual aborters and control women exhibited no change in the urinary output of the stable degradation products of prostacyclin and TXA2 when studied between 0 and 2 and 5 and 8 days after the luteinizing hormone peak. Habitual aborters as a whole, or when subgrouped to those with normal (10 cycles) or defective luteal function (12 cycles) did not differ from the control series with regard to prostacyclin and TXA2 production.


CONCLUSIONS
Productions of prostacyclin and TXA2 are not relative to the luteal function and are normal in nonpregnant women with a history of habitual abortion.
Tulppala
M
M
Department I of Obstetrics and Gynecology Children's Hospital, University Central Hospital of Helsinki, Finland.
Viinikka
L
L
Ylikorkala
O
O
D000026:Abortion, Habitual / Q000378:metabolism / Q000503:physiopathology*; D000328:Adult; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008183:Luteal Phase; D008499:Medical Records; D011247:Pregnancy; D013928:Thromboxane A2 / Q000096:biosynthesis*
D013928:Thromboxane A2; D011464:Epoprostenol