The role of the MHC in autoimmunity: an overview.
The basis for MHC associations with autoimmune diseases is still unknown; however, recent progress in the study of the MHC, its gene products and their functions suggests a number of possible mechanisms. These paradigms are described and their applicability to particular autoimmune diseases is considered.
Mellins
E D
ED
Department of Pediatrics, University of Washington, Seattle.
D000938:Antigen-Presenting Cells / Q000502:physiology; D001327:Autoimmune Diseases / Q000503:physiopathology; D015551:Autoimmunity / Q000502:physiology*; D005796:Genes; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000502:physiology*; D008954:Models, Biological; D013601:T-Lymphocytes / Q000502:physiology
D006680:HLA Antigens