title: The influence of isoflurane on the vascular reflex response to lung inflation in dogs.
abstract: Positive pressure ventilation can affect hemodynamic stability by neuroreflex-mediated activity. Inhalational anesthesia is known to attenuate the arterial baroreflex function; however, little information is known about the effect of volatile anesthetics on the lung inflation reflex. The influence of isoflurane on static lung inflation reflex-induced changes in venous capacitance and systemic resistance was investigated in dogs. After controlling carotid sinus pressure at 50 mmHg and initiating total cardiopulmonary bypass, the lungs were inflated to tracheal pressures of 10 and 20 mmHg. The systemic vascular resistance index (SVRI) decreased by 0.04 +/- 0.03 and 0.13 +/- 0.03 mmHg.kg.min.ml-1 during tracheal inflation pressures of 10 and 20 mmHg, respectively. There as an accompanying change in systemic vascular capacitance index (SVCI) by 1.0 +/- 0.65 and 3.3 +/- 0.82 ml.kg-1 during tracheal inflation pressures of 10 and 20 mmHg. The addition of isoflurane decreased the reflex vascular response to lung inflation in a dose-dependent manner. A concentration of 1 MAC isoflurane administered via the cardiopulmonary bypass machine attenuated the change in SVRI to tracheal inflation pressures of 10 and 20 mmHg by 75% and 67%, respectively. Isoflurane at 1 MAC also reduced the reflex capacitance response to tracheal pressures of 10 and 20 mmHg by 36% each. Lung inflation-induced changes in SVRI and SVCI were abolished at isoflurane concentrations of 2 MAC. We conclude that under the conditions of this study, 1 MAC isoflurane was shown to attenuate lung reflex-induced changes in SVRI and SVCI and that at higher isoflurane concentrations (2 MAC) these reflex-induced changes were not seen.
authors.affiliation: Department of Anesthesiology, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: E Y
authors.initials: EY
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Kay
authors.forename: S
authors.initials: S
authors.lastname: Hoka
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Bosnjak
authors.forename: R L
authors.initials: RL
authors.lastname: Coon
authors.forename: J P
authors.initials: JP
authors.lastname: Kampine
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D007530:Isoflurane / Q000494:pharmacology*; D008168:Lung / Q000502:physiology*; D011175:Positive-Pressure Respiration; D012018:Reflex / Q000187:drug effects* / Q000502:physiology
chemical_list: D007530:Isoflurane