Increased mucin levels in submandibular saliva from mice following repeated isoproterenol treatment.
Mucin decreases with age in the submandibular glands of mice and can be restored by chronic administration of isoproterenol. Mice were given repeated injections of isoproterenol to determine if the increase of mucin in the submandibular gland leads to elevated levels of mucin in the submandibular saliva. Mucin was significantly elevated in both the gland and the saliva after isoproterenol. Gland contents of mucin and the concentration of mucin in their salivas were positively correlated for both the isoproterenol (p = 0.01) and the control group (p less than 0.01).
Denny
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PA
Department of Basic Sciences, School of Dentistry, University of Southern California, Los Angeles 90089-0641.
Hong
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SH
Klauser
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DK
Denny
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PC
D000818:Animals; D005260:Female; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D009077:Mucins / Q000032:analysis*; D009929:Organ Size; D010862:Pilocarpine / Q000494:pharmacology; D012463:Saliva / Q000737:chemistry / Q000187:drug effects*; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D013363:Submandibular Gland / Q000187:drug effects* / Q000378:metabolism
D009077:Mucins; D012471:Salivary Proteins and Peptides; D010862:Pilocarpine; D007545:Isoproterenol