[A preliminary study on the mechanism of immune injury of Menière's disease--type V collagen play the role of antigen].
In the serum of patients with Meniere's disease, we have found significantly increased circular immune complex with solid C1q ELISA method (P less than 0.01), significantly increased anti-human placental type-V collagen antibody with ELISA method (P less than 0.01) and significantly increased immunoglobulin G and immunoglobulin M with single directional radiation immunodiffusion (P less than 0.01) when compare to control group. We have also induced spontaneous nystagmus by inoculating guinea pigs with this collagen. As a result, in the autoimmune lesion of Meniere's disease, type-V collagen may have an important role as antigen.
Zou
J
J
Third Affiliate Hospital, Third Military Medical College, Chongqing City.
D000328:Adult; D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D003094:Collagen / Q000276:immunology* / Q000502:physiology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008575:Meniere Disease / Q000139:chemically induced / Q000276:immunology*; D008875:Middle Aged
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003094:Collagen