Antigen receptors on B lymphocytes.
Recent studies on the structure of the B cell antigen receptor demonstrate that the membrane-bound and antigen-binding immunoglobulin molecules are noncovalently associated with a heterodimer of two novel transmembrane proteins. The B cell antigen receptor is thus a multicomponent receptor complex whose structural features are similar to those of the T cell antigen receptor complex. Cross-linking of the B cell antigen receptor results in rapid tyrosine phosphorylation of substrate proteins. This suggests that the B cell receptor belongs to a subgroup of the tyrosine kinase receptor family with a noncovalently associated src-like tyrosine kinase.
Reth
M
M
Max-Planck-Institut für Immunobiologie, Freiberg, Germany.
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007072:Immunoglobulin D / Q000235:genetics; D007075:Immunoglobulin M / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D011947:Receptors, Antigen, B-Cell / Q000737:chemistry / Q000235:genetics
D007072:Immunoglobulin D; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell