[Synthesis of alpha-chrysanthemylmethyl-gamma- and delta-lactones with cytostatic activity].
The synthesis of the alpha-chrysanthemylmethylen-gamma- and delta-lactones 7-9, 11, 12 from the lactones 1-3, 5 and that of 10 from 2-oxo-chroman (4) and the aldehyd 6 is described. The compounds 7-9 and 11, 12 show cytostatic activity.
Falsone
G
G
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Trieste, Trieste, Italia.
Cateni
F
F
el-Alali
A
A
Papaioannau
A
A
Ravalico
L
L
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011722:Pyrethrins / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D007783:Lactones; D011722:Pyrethrins
Synthese von alpha-Chrysanthemylmethylen-gamma- und delta-Lactonen mit zytostatischer Wirkung.