Preferential excretion of glycated albumin in C57BL-Ks-J mice: effects of diabetes.
Urinary excretion of glycated albumin was quantitated in genetically hyperglycemic mice (C57BL-Ks-J, db/db mice), a model for non-insulin-dependent diabetes mellitus, and compared with their non-diabetic littermates. The data indicated a preferential excretion of glycated albumin in non-diabetic mice. This phenomenon of 'editing' of glycated albumin is decreased significantly in diabetic mice. Quantitative measurements of overall excretion of glycated albumin suggested that the loss of editing in diabetic mice is due to the dilution of glycated albumin by the unmodified albumin which is excreted in large amounts in diabetic mice. Therefore, the loss of editing observed in this model resembled the one we characterized in insulin-dependent diabetic humans and a streptozotocin-diabetic rat model.
Kowluru
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Division of Life Sciences, Los Alamos National Laboratory, University of California, New Mexico 87545.
Kowluru
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D000419:Albuminuria; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000652:urine*; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced; D051379:Mice; D008810:Mice, Inbred C57BL; D012709:Serum Albumin; D000093423:Glycated Serum Albumin
D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin