Molecular cloning of a novel adenosine receptor gene from rat brain.
We have isolated an adenosine receptor gene (RA2) from a rat brain cDNA library. This novel rat adenosine receptor has 410 amino acids, as deduced from its base sequence, and shows 82% amino acid identity with the dog A2 receptor. Amino acid sequence analysis indicates that RA2 protein contains seven transmembrane domains and belongs to the G protein-coupled receptor family. The variations in amino acid sequences between RA2 protein and the dog A2 receptor are largely confined to the extracellular second loop and the carboxyl terminus.
Chern
Y
Y
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, R.O.C.
King
K
K
Lai
H L
HL
Lai
H T
HT
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry; D003001:Cloning, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D051381:Rats; D011983:Receptors, Purinergic / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D011983:Receptors, Purinergic