Susceptibility of anaerobic bacteria to tosufloxacin.
The in vitro activity of tosufloxacin against anaerobic cocci, Propionibacterium acnes, Clostridium perfringens, Clostridium difficile, Bacteroides fragilis, Bacteroides spp. and fusobacteria was determined by the agar dilution method. This activity was compared with that of ciprofloxacin, piperacillin, cefoxitin, imipenem, clindamycin, metronidazole and chloramphenicol. Tosufloxacin, imipenem, clindamycin, metronidazole and chloramphenicol were the most active agents tested. Tosufloxacin has an antibacterial activity that warrants investigation in clinical trials.
Nord
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CE
Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Sweden.
Lindmark
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A
Persson
I
I
Runow
C
C
D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*
D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C055185:tosufloxacin