The Y-associated XY275 low allele is not restricted to indigenous African peoples.
The level of linkage disequilibrium between the XY275 MspI polymorphism and the X and Y boundaries was investigated in 21 different southern African populations. A full range of frequencies of the high allele was observed on the 1,013 X chromosomes studied, in keeping with published data. In previous studies fixation of the high allele on the Y chromosome was observed in all but two groups--a Pygmy and a Tsumkwe San population. However, in the present study of 673 Y chromosomes, the low allele was found to be associated with the Y chromosome in several different Bantu-speaking negroid groups, the Khoisan-speaking negroid Dama, the Khoisan, two groups of mixed ancestry, and the South African Asiatic-Indian population. The discovery of the low allele on Y chromosomes of caucasoid individuals suggests that more than one class of Y chromosome gave rise to the present-day non-African population. The data also fail to provide support for the theory that Africa is the site of origin of Homo sapiens, but they equally do not exclude it.
Spurdle
A
A
Department of Human Genetics, School of Pathology, South African Institute for Medical Research, Johannesburg.
Ramsay
M
M
Jenkins
T
T
D000353:Africa, Southern; D000483:Alleles; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D044383:Black People / Q000235:genetics*; D002874:Chromosome Mapping; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D015186:Hominidae / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D016133:Polymerase Chain Reaction; D044465:White People / Q000235:genetics*; D014960:X Chromosome; D014998:Y Chromosome
D009838:Oligodeoxyribonucleotides