title: Long-term followup after nephron sparing surgery for renal cell carcinoma in von Hippel-Lindau disease.
abstract: We reviewed the long-term outcome of nephron sparing surgery in 9 patients with localized bilateral renal cell carcinoma and von Hippel-Lindau disease. One patient died of metastatic renal cell carcinoma 43 months postoperatively. One patient has not had recurrent tumor and was alive at 74 months postoperatively. The remaining 7 patients (mean followup 88 months) had local recurrence of tumor in the operated kidney and a secondary renal operation was done in 6 of them. Overall, 6 patients are free of tumor but only 3 of them retain functioning native renal parenchyma. We conclude that the results of nephron sparing surgery in patients with renal cell carcinoma and von Hippel-Lindau disease are less satisfactory than in patients with sporadic renal cell carcinoma.
authors.affiliation: Department of Urology, Cleveland Clinic Foundation, Ohio 44195.
authors.forename: A C
authors.initials: AC
authors.lastname: Novick
authors.forename: S B
authors.initials: SB
authors.lastname: Streem
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000556:secondary / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009399:Nephrons; D013514:Surgical Procedures, Operative / Q000379:methods; D013997:Time Factors; D006623:von Hippel-Lindau Disease / Q000150:complications*