Enhanced vasodilatory responses to bradykinin in stroke-prone spontaneously hypertensive rats.
Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from SHRSP and WHY. BK-induced dilatation was greater in kidneys from SHRSP relative to WHY and was not affected by indomethacin or captopril. These results indicate that renal vasodilatory responsiveness to bradykinin is enhanced in SHRSP with established hypertension.
Stier
C T
CT
Department of Pharmacology, New York Medical College, Valhalla 10595.
Selig
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N
Itskovitz
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HD
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002561:Cerebrovascular Disorders / Q000235:genetics*; D004198:Disease Susceptibility; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D000109:Acetylcholine; D001920:Bradykinin