A method for identifying external control sites in metabolic systems.
A graphic method is presented for the identification of control sites in a metabolic system. This method is based on the matrix method for calculating net sensitivities developed by Crabtree and Newsholme (Biochem. J. 247: 113-120, 1987) and avoids the misidentification of control sites that can result from a simple inspection of a system. The method is easily adapted for analysis by computer and may be used for preliminary investigations of metabolic systems to identify potential control sites for further more quantitative investigations.
Crabtree
B
B
Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom.
D000818:Animals; D001330:Electronic Data Processing; D006801:Humans; D007700:Kinetics; D008660:Metabolism / Q000502:physiology*; D008954:Models, Biological