Nonrandom association of atrioventricular canal and del (8p) syndrome.
We describe a patient with partial deletion of the short arm of chromosome 8 with an atrioventricular canal. This type of congenital heart defect was found in 4 of the 7 previously reported del (8p) children with a congenital heart defect in which the cardiac assessment was complete. The prevalence of an atrioventricular canal in this aneuploidy is high and suggests a nonrandom association of the 2 anomalies.
Marino
B
B
Department of Pediatric Cardiology and Genetics, Bambino Gesù Hospital, Rome, Italy.
Reale
A
A
Giannotti
A
A
Digilio
M C
MC
Dallapiccola
B
B
D000015:Abnormalities, Multiple / Q000235:genetics; D002872:Chromosome Deletion; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006330:Heart Defects, Congenital / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009006:Monosomy; D009206:Myocardium / Q000473:pathology*