Sustained release of 5-fluorouracil from oil/water emulsions.
Release profile of 5-fluorouracil (5-FU) from O/W emulsion and bone marrow toxicity of 5-FU to mice were compared with those of an aqueous solution of 5-FU. 5-FU emulsion had lower bone marrow toxicity and a slower drug release rate than the 5-FU aqueous solution which exhibited high bone marrow toxicity and fast drug release rate. A correlation between the rate of drug release and bone marrow toxicity was suggested.
Ishikawa
M
M
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Kikuta
H
H
Imaizumi
A
A
Suzuki
E
E
Takayanagi
Y
Y
Sasaki
K
K
D000818:Animals; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000473:pathology; D003692:Delayed-Action Preparations; D004655:Emulsions; D005472:Fluorouracil / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000633:toxicity; D051379:Mice; D009821:Oils; D014867:Water
D003692:Delayed-Action Preparations; D004655:Emulsions; D009821:Oils; D014867:Water; D005472:Fluorouracil