title: The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro.
abstract: Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.
authors.affiliation: Department of Virology, Glaxo Group Research Ltd., Greenford, Middlesex, United Kingdom.
authors.forename: J A
authors.initials: JA
authors.lastname: Coates
authors.forename: N
authors.initials: N
authors.lastname: Cammack
authors.forename: H J
authors.initials: HJ
authors.lastname: Jenkinson
authors.forename: I M
authors.initials: IM
authors.lastname: Mutton
authors.forename: B A
authors.initials: BA
authors.lastname: Pearson
authors.forename: R
authors.initials: R
authors.lastname: Storer
authors.forename: J M
authors.initials: JM
authors.lastname: Cameron
authors.forename: C R
authors.initials: CR
authors.lastname: Penn
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D003596:Cytosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D019259:Lamivudine; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D019259:Lamivudine; D003596:Cytosine