[Effects of rhynchophylline and isorhynchophylline on blood pressure and blood flow of organs in anesthetized dogs].
In anesthetized thoracotomized dogs, rhynchophylline (Rhy 5 mg.kg-1, iv) reduced the mean arterial pressure (MAP), heart rate (HR), and coronary blood flow (CBF) by 1.16 +/- s 0.67 kPa, 19 +/- 12 beats/min, and 0.12 +/- 0.04 ml.min-1.g-1, whereas isorhynchophylline (Isorhy 1 mg.kg-1, iv) reduced the parameters by 3.58 +/- 0.19 kPa, 26 +/- 18 beats/min, and 0.10 +/- 0.04 ml.min-1.g-1, respectively. In unthoracotomized dogs, Rhy (10 mg.kg-1, iv) decreased renal blood flow (RBF) by 0.35 +/- 0.16 ml.min-1.g-1, but did not change the MAP. Isorhy (5 mg.kg-1, iv) reduced the MAP by 3.44 +/- 1.44 kPa, but the RBF remained unaffected. These results indicated that the hypotensive effect of Isorhy in a dosage not affecting RBF was more potent than that of Rhy.
Shi
J S
JS
Department of Pharmacology, Zunyi Medical College, China.
Liu
G X
GX
Wu
Q
Q
Huang
Y P
YP
Zhang
X D
XD
D000470:Alkaloids / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D026121:Indole Alkaloids; D007668:Kidney / Q000098:blood supply; D000078183:Oxindoles; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
D000470:Alkaloids; D000959:Antihypertensive Agents; D026121:Indole Alkaloids; D000078183:Oxindoles; C052714:rhyncophylline