title: Human immunodeficiency virus type 1 enhances intracellular growth of Mycobacterium avium in human macrophages.
abstract: Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human macrophages. Human monocytes isolated from the peripheral blood of healthy individuals were infected with HIV-1, M. avium, or both. The intracellular growth of M. avium and the replication of HIV-1 were monitored for up to 5 weeks. Intracellular mycobacterial growth was seen in all M. avium infected cell cultures and was paralleled by increased production of interleukin 1 alpha and beta. Preinfection of the macrophages with HIV-1 reduced the interleukin 1 production and accelerated the intracellular growth of M. avium. These findings may explain in part the impaired control of mycobacterial infections seen with patients with AIDS.
authors.affiliation: National Bacteriological Laboratory, Karolinska Institute, Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Källenius
authors.forename: T
authors.initials: T
authors.lastname: Koivula
authors.forename: K J
authors.initials: KJ
authors.lastname: Rydgård
authors.forename: S E
authors.initials: SE
authors.lastname: Hoffner
authors.forename: A
authors.initials: A
authors.lastname: Valentin
authors.forename: B
authors.initials: B
authors.lastname: Asjö
authors.forename: C
authors.initials: C
authors.lastname: Ljungh
authors.forename: U
authors.initials: U
authors.lastname: Sharma
authors.forename: S B
authors.initials: SB
authors.lastname: Svenson
mesh_terms: D002478:Cells, Cultured; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D008264:Macrophages / Q000382:microbiology*; D009162:Mycobacterium avium / Q000254:growth & development*; D014779:Virus Replication
chemical_list: D007375:Interleukin-1