Improved insulin sensitivity in hyperinsulinaemic ponies through physical conditioning and controlled feed intake.
Ten hyperinsulinaemic ponies divided into conditioned (N = 5) and rested (N = 5) groups were evaluated for their insulin and glucose response following oral glucose administration at Weeks 0, 2, 4, and 6. All ponies received a controlled intake of a pelleted ration during the study. In both groups body weight had decreased from baseline by Week 4 and remained low. After 2 weeks of exercise, ponies in the conditioned group had significantly decreased insulin and glucose indices, including peak insulin response, area under the insulin curve from 0 to 210 min (TIS), and the TIS value: area under the glucose curve from 0 to 210 min. By Week 4 of conditioning, although the insulin and glucose indices continued to decrease in the exercised ponies, there was no significant difference between the groups. Over the first 6 weeks of the study all ponies improved their insulin sensitivity accompanied by a loss of body weight. The conditioned ponies were further evaluated during deconditioning at Weeks 8, 10 and 12. The improved insulin sensitivity was maintained during deconditioning.
Freestone
J F
JF
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
Beadle
R
R
Shoemaker
K
K
Bessin
R T
RT
Wolfsheimer
K J
KJ
Church
C
C
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D004435:Eating; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D006946:Hyperinsulinism / Q000628:therapy / Q000662:veterinary*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D009752:Nutritional Status; D010805:Physical Conditioning, Animal
D001786:Blood Glucose; D007328:Insulin