Capsaicin-like activity of N-ethylmaleimide in rat stomach.
1. N-Ethylmaleimide (NEM) and capsaicin induced a release of calcitonin gene-related peptide-like immunoreactivity (CGRP-li) in superfusates from rat gastric corpus. 2. The prior application of capsaicin completely blocked CGRP-li release by NEM while the exposure to NEM reduced the capsaicin-evoked CGRP-li outflow by about 51%. 3. These findings provide evidence that NEM might exert capsaicin-like activity in rat stomach and the release of CGRP-li from capsaicin-sensitive afferent fibres might influence the properties exerted by NEM in this tissue.
Evangelista
S
S
Pharmacology Department, Malesii Pharmaceuticals, Firenze, Italy.
Renzi
D
D
Guzzi
P
P
Surrenti
C
C
Santicioli
P
P
Maggi
C A
CA
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000276:immunology / Q000378:metabolism*; D002211:Capsaicin / Q000494:pharmacology*; D005033:Ethylmaleimide / Q000494:pharmacology*; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects* / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D013270:Stomach / Q000187:drug effects / Q000294:innervation*
D015740:Calcitonin Gene-Related Peptide; D005033:Ethylmaleimide; D002211:Capsaicin