Effect of hydrochlorothiazide on renal hypercalciuria.
The long-term effect of hydrochlorothiazide (HCT) was studied in 30 children (17 boys and 13 girls), aged 4-13 years (mean 7.6 +/- 3.4), with renal hypercalciuria (HCU) for a period of 2.5 +/- 0.95 years. The purpose of the study was to evaluate the effect of HCT mainly on renal calcium excretion, but also on serum K+, Ca, P, Mg, cPTH, nephrogenic cAMP (ncAMP) and bone mineral content (BMC). In addition to the above-mentioned parameters, oxalate, uric acid, citrate and cystine levels in 24-hour urine collections were also measured, and UCa/UCr, UP/UCr, UMg/UCr in 3-hour urine collections were assayed. The results of the study showed that 1 mg/kg/day of HCT caused a rapid and long-lasting correction of HCU, a decrease in serum cPTH and ncAMP, a significant increase in BMC and prevention of the formation of new urinary stones or of the increase in size of stones already present. No side effects were observed.
Voskaki
I
I
Institute of Child Health, Aghia Sophia Children's Hospital, Athens, Greece.
al Qadreh
A
A
Mengreli
C
C
Sbyrakis
S
S
D015519:Bone Density; D002118:Calcium / Q000652:urine*; D002648:Child; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D007669:Kidney Calculi / Q000097:blood / Q000188:drug therapy / Q000652:urine; D008297:Male; D013997:Time Factors
D006852:Hydrochlorothiazide; D002118:Calcium