Occurrence of (E)-4-hydroxy-2-nonenal in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis.
(E)-4-Hydroxy-2-nonenal (HNE), a cytotoxic propagation product of lipid peroxidation, is present in the synovial fluid (0.54 (0.19) mumol/l; mean (SE), n = 9) and plasma (0.34 (0.09) mumol/l, n = 9) of patients with rheumatoid arthritis. This compound was also found in the synovial fluid (0.24 (0.19) mumol/l, n = 9) and plasma (0.09 (0.03) mumol/l, n = 9) of patients with osteoarthritis. The concentration of HNE in the plasma of patients with rheumatoid arthritis was significantly greater than in patients with osteoarthritis.
Selley
M L
ML
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Royal Canberra Hospital, Garran, ACT.
Bourne
D J
DJ
Bartlett
M R
MR
Tymms
K E
KE
Brook
A S
AS
Duffield
A M
AM
Ardlie
N G
NG
D000447:Aldehydes / Q000032:analysis* / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D010003:Osteoarthritis / Q000378:metabolism*; D013582:Synovial Fluid / Q000737:chemistry*
D000447:Aldehydes; C027576:4-hydroxy-2-nonenal