Nursing sickness in lactating mink (Mustela vison). II. Pathophysiology and changes in body fluid composition.
An investigation of the pathophysiological characteristics of nursing sickness in mink was carried out as a follow-up study of a previous epidemiological survey at a Danish fur research farm during the 1989 breeding season. In a total of 48 nursing females of the Standard Black and Pastel type, concentrations of several pertinent biochemical constituents of whole blood, plasma, urine and skeletal muscle were determined in order to identify nutritional and metabolic factors involved in the origin and development of the disease. Compared to the reference data obtained in 17 apparently normal lactating dams the findings in 31 females suffering from nursing sickness presented varying clinical and biochemical signs of progressive dehydration and emaciation: aldosteronism, hypovolemia, hyponatremia, hyperkalemia (in the face of muscle potassium depletion), hyperglycemia and azotemic acidemia. Neither ketosis nor severe lactacidemia was observed. The urine was almost devoid of sodium and chloride, and urinary potassium concentration diminished by approximately 50%. The concentrating ability of the kidneys was reduced to less than one third of the maximum value. The results were consistent with severe dehydration and emaciation due to heavy losses of energy, water and body mass along with increasing milk production. The progressive nature of the disease supported the hypothesis that nursing sickness is due to the combined effects of heavy milk production and excessive tissue catabolism along with reduced or ceased dietary intake, and maybe increasing environmental stress. In the advanced stage of the disease coma and death appear to be the inevitable outcome of the metabolic strains for continuing milk production.
Wamberg
S
S
Department of Physiology, Odense University, Denmark.
Clausen
T N
TN
Olesen
C R
CR
Hansen
O
O
D000136:Acid-Base Equilibrium; D000450:Aldosterone / Q000097:blood; D000818:Animals; D001826:Body Fluids / Q000737:chemistry*; D001835:Body Weight; D004573:Electrolytes / Q000032:analysis / Q000097:blood / Q000652:urine; D005260:Female; D007775:Lactation Disorders / Q000503:physiopathology / Q000662:veterinary*; D008098:Litter Size; D008907:Mink; D009132:Muscles / Q000737:chemistry; D014886:Weaning
D004573:Electrolytes; D000450:Aldosterone