[Neurobiochemistry of experimental lesions of the basal nucleus of Meynert].
Lesions of the nucleus basalis magnocellularis (of Meynert) in rats induce severe cognitive impairments, in both mnesic and attentional functions. During the last 10 years, many studies tended to establish some relationships between the behavioral and biochemical effects of such lesions. Recent data show that the activity of some peptidergic and glutamaterigic neurons in target areas is modified by cholinergic deafferentation. A new physiological interpretation may be proposed for the associated cognitive deficits.
Reine
G
G
Unité de neurochimie, CNRS, Marseille.
Nieoullon
A
A
D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D002799:Cholinergic Fibers / Q000502:physiology; D003072:Cognition Disorders / Q000503:physiopathology*; D004195:Disease Models, Animal; D009448:Neurochemistry; D051381:Rats; D011950:Receptors, Cholinergic / Q000032:analysis; D013377:Substantia Innominata / Q000737:chemistry / Q000473:pathology / Q000503:physiopathology*
D011950:Receptors, Cholinergic
Neurobiochimie des lésions expérimentales du noyau basal de Meynert.