Survival of patients with t(1;7)(p11;p11). Report of two cases and review of the literature.
t(1;7)(p11;p11) is a relatively rare chromosome aberration, in most cases associated with acute myeloid leukemia or myelodysplasia. Earlier, many patients received chemotherapy for a malignant disease. The prognosis is usually poor. I describe two patients and review the literature. Thirty-six of the 73 had a history of previous exposure to chemotherapy or radiotherapy. Alkylating agents had been used in 29. The median survival after observation of the translocation was only 11 months, a much shorter survival time than is common for patients with secondary hematologic disorders. Sex, diagnosis, hemoglobin concentration, and percentage of metaphases containing t(1;7) were independent prognostic factors. Despite its relation to earlier chemotherapy, the chromosome aberrations associated with t(1;7) lack the cytogenetic features characteristic of therapy-induced disorders.
Pedersen
B
B
Danish Cancer Society, Department of Cytogenetics, Aarhus Amtssygehus.
D000970:Antineoplastic Agents / Q000009:adverse effects; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000139:chemically induced / Q000235:genetics; D011379:Prognosis; D014178:Translocation, Genetic
D000970:Antineoplastic Agents