Novel thiazolidine-2,4-diones as potent euglycemic agents.
A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.
Hulin
B
B
Central Research, Pfizer Inc., Groton, Connecticut 06340.
Clark
D A
DA
Goldstein
S W
SW
McDermott
R E
RE
Dambek
P J
PJ
Kappeler
W H
WH
Lamphere
C H
CH
Lewis
D M
DM
Rizzi
J P
JP
D000438:Alcohols / Q000737:chemistry; D000818:Animals; D001578:Benzopyrans / Q000737:chemistry; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D007659:Ketones / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045162:Thiazolidinediones
D000438:Alcohols; D001578:Benzopyrans; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007659:Ketones; D013844:Thiazoles; D045162:Thiazolidinediones; C066021:englitazone