Protective effect of schisanhenol against oxygen radical induced mitochondrial toxicity on rat heart and liver.
Schisanhenol (SAL) had been shown to have potent antioxidant activities. The protective effects of SAL against oxygen radical induced mitochondrial injuries of rat heart and liver were investigated in the present study. The ferrous-cysteine induced mitochondrial lipid peroxidation was significantly inhibited by SAL, while the loss of ATPase activity induced by the lipid peroxidation was prevented. The rigidification of mitochondrial membrane, as well as swelling, lysis and disintegration of the mitochondria induced by ferrous-cysteine were all significantly inhibited by SAL. These results further confirm that SAL possesses antioxidant activity.
Lin
T
T
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
Liu
G
G
Pan
Y
Y
D000818:Animals; D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016166:Free Radical Scavengers; D005609:Free Radicals; D015227:Lipid Peroxidation; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008933:Mitochondrial Swelling / Q000187:drug effects; D010100:Oxygen / Q000633:toxicity*; D011083:Polycyclic Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D005609:Free Radicals; D011083:Polycyclic Compounds; C045309:schisanhenol; D010100:Oxygen