title: The natural history of isolated left ventricular diastolic dysfunction.
abstract: OBJECTIVE
  To assess the natural history of isolated left ventricular diastolic dysfunction.
  
  
  METHODS
  Follow-up (average duration, 68 months) was obtained in 51 patients with isolated left ventricular diastolic dysfunction at cardiac catheterization, characterized by (1) an elevated left ventricular end-diastolic pressure; (2) normal left ventricular end-diastolic and end-systolic volumes; (3) normal left ventricular ejection fraction; (4) no coronary artery disease; and (5) no valvular disease.
  
  
  RESULTS
  During follow-up, seven patients died, but only one died of cardiac causes. Of the 44 living subjects, 20 (45%) noted new-onset symptoms of congestive heart failure, with 11 (25%) of these requiring hospitalization, and 12 (27%) required hospitalization for recurrent chest pain.
  
  
  CONCLUSIONS
  Isolated left ventricular diastolic dysfunction is associated with a low cardiac mortality; at the same time, however, it is associated with substantial morbidity.
authors.affiliation: Department of Internal Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, Dallas 75235.
authors.forename: W C
authors.initials: WC
authors.lastname: Brogan
authors.forename: L D
authors.initials: LD
authors.lastname: Hillis
authors.forename: E D
authors.initials: ED
authors.lastname: Flores
authors.forename: R A
authors.initials: RA
authors.lastname: Lange
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D006328:Cardiac Catheterization; D002637:Chest Pain / Q000453:epidemiology / Q000209:etiology; D003971:Diastole; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D006333:Heart Failure / Q000453:epidemiology / Q000209:etiology; D006786:Hospitals, Urban; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D016019:Survival Analysis; D013781:Texas / Q000453:epidemiology; D016277:Ventricular Function, Left