Evaluation of spermatozoa of the rat in hyperprolactinaemia induced by metoclopramide.
Metoclopramide (MCP) in doses of 2.2 mg kg-1 body weight, being administered intraperitoneally to rats for 14 d, provokes a premature release of germ cells in the testes. The number of spermatozoa is reduced. In addition the spermatozoa exhibit defects of head and tail structures. After the administration of MCP for 14 d, followed by a 14-d break in applying the drug, the number of spermatozoa in the lumen of the epididymal duct continues to be low. Many spermatozoa are damaged. Only after a 66-d-break in MCP administration is the morphology of the seminiferous epithelium restored, and a large number of spermatozoa appear in the lumen of the epididymal duct.
Laszczyńska
M
M
Department of Histology and Embryology, Pomeranian Medical Academy, Szczecin, Poland.
Rózewicka
L
L
Kuchnio
M
M
Piasecka
M
M
Marchlewicz
M
M
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004822:Epididymis / Q000187:drug effects / Q000473:pathology; D006966:Hyperprolactinemia / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology* / Q000633:toxicity; D008854:Microscopy, Electron; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D013094:Spermatozoa / Q000187:drug effects / Q000473:pathology / Q000502:physiology* / Q000648:ultrastructure
D011388:Prolactin; D008787:Metoclopramide