title: Subacute oral toxicity study of benzyl isothiocyanate in rats.
abstract: The subacute toxicity of benzyl isothiocyanate (BITC) was investigated in male rats given oral doses of 0, 50, 100 and 200 mg/kg body weight/day for 4 weeks. Body weight gain and food consumption were decreased with increasing doses of BITC. Haematological changes of toxicological relevance were observed in the highest dose group. BITC administration resulted in increased serum cholesterol level in all treatment groups and decreased serum triglycerides level at 200 mg/kg. Renal dysfunction was indicated by reduced urine volume, proteinuria and enhanced urinary lactate dehydrogenase activity. BITC exposure also affected the weights of various organs and caused histological changes in the ductus choledochus, liver, ileum and mesenteric lymph nodes.
authors.affiliation: German Institute for Nutrition Research Potsdam-Rehbrücke.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lewerenz
authors.forename: D W
authors.initials: DW
authors.lastname: Bleyl
authors.forename: R
authors.initials: R
authors.lastname: Plass
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004435:Eating / Q000187:drug effects; D017879:Isothiocyanates; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013861:Thiocyanates / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood; D014556:Urine / Q000737:chemistry
chemical_list: D017879:Isothiocyanates; D013861:Thiocyanates; D014280:Triglycerides; C031403:benzyl isothiocyanate; D002784:Cholesterol