title: Spermatogenesis and reproductive performance following human accidental exposure to bromine vapor.
abstract: The present study was undertaken to evaluate spermatogenesis and reproductive performance among 8 men and their spouses following accidental exposure to bromine vapor. Of the three cases with oligo-terato-asthenozoospermia (OTA), one had been diagnosed prior to and unrelated to the event. Mild OTA and unimpaired reproductive performance characterized the other two cases. Plasma levels of the follicle stimulating hormone and luteinizing hormone were normal in all men. One first-trimester abortion and one late abortion (due to chorioamnionitis) occurred among the 5 pregnancies conceived shortly after the accident. Results of the present study suggest a mild degree of spermatogenic suppression and impaired reproductive performance following paternal exposure to bromine vapor during the above described accident. However, due to the small size of the study cohort, a confidential cause-result linkage could not be established.
authors.affiliation: Division of Obstetrics and Gynecology, Soroka Medical Center, Beer-Sheva, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Potashnik
authors.forename: R
authors.initials: R
authors.lastname: Carel
authors.forename: I
authors.initials: I
authors.lastname: Belmaker
authors.forename: M
authors.initials: M
authors.lastname: Levine
mesh_terms: D000062:Accidents, Occupational; D000328:Adult; D001966:Bromine / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000139:chemically induced; D011247:Pregnancy; D011256:Pregnancy Outcome; D012098:Reproduction / Q000187:drug effects*; D012661:Semen / Q000166:cytology / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D001966:Bromine