Agelasine G, a new antileukemic alkaloid from the Okinawan marine sponge Agelas sp.
A new antileukemic alkaloid, agelasine G (1a), has been isolated from the Okinawan marine sponge Agelas sp. and its structure elucidated to be a bromopyrrole alkaloid containing 9-methyladenine and diterpene moieties on the basis of the spectroscopic data.
Ishida
K
K
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Ishibashi
M
M
Shigemori
H
H
Sasaki
T
T
Kobayashi
J
J
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; C075210:agelasine G; D000225:Adenine