title: Vulvar destruction by malignant lymphoma.
abstract: Two cases of vulvar and perineal destruction by malignant lymphoma are described. The first case was of an untreated 4-year-long vulvar destruction due to a kappa-positive lymphoplasmacytic lymphoma that ultimately resulted in the death of the patient. The second patient had involvement of the vulva and perineum by an angiocentric small and large mixed-cell lymphoma. Aggressive chemotherapy induced regression and healing of the lesions in the second case. Delayed diagnosis and inappropriate management of lymphomas in the vulva may lead to widely destructive disease of the lower female genital tract.
authors.affiliation: Anatomic Pathologic Division, INCOR, Hospital das Clínicas, University of São Paulo School of Medicine, Brazil.
authors.forename: R M
authors.initials: RM
authors.lastname: Tuder
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008875:Middle Aged; D014844:Vulva / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology*