Rh segregation distortion: an artifact of ascertainment bias?
On the basis of Rh blood group data on mother-child pairs collected from the maternity clinic of a hospital in Chile, Valenzuela and Harb postulated that there is a significant segregation distortion at the Rh locus. For data collected from a hospital, biases of ascertainment cannot be ruled out. For the Rh blood group locus, there is a strong possibility of preferential admission of Rh(-) pregnant women, especially of those Rh(-) women with Rh(+) husbands. We show that the evidence of segregation distortion vanishes when the possibility of such preferential admissions are taken into account.
Nath
S K
SK
Anthropometry and Human Genetics Unit, Indian Statistical Institute, Calcutta.
Majumder
P P
PP
Sarkar
S
S
D000328:Adult; D003433:Crosses, Genetic; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008540:Meiosis; D008957:Models, Genetic; D010641:Phenotype; D011247:Pregnancy; D011336:Probability; D012204:Rh-Hr Blood-Group System / Q000235:genetics*
D012204:Rh-Hr Blood-Group System