Inhibition of liposomal lipid peroxidation by spermidine.
Spermidine was found to inhibit the in vitro formation of thiobarbituric acid-reactive material from sonicated vesicles of rat brain and individual phospholipids, especially in the presence of externally added iron. With arachidonic acid incorporated liposomes spermidine inhibited lipid peroxidation in the presence or the absence of Fe2+, to similar extent. Thus spermidine inhibition of lipid peroxidation may not be entirely iron-dependent.
Awasthi
S
S
Department of Pathology, University of Texas Medical Branch, Galveston 77550.
Kakkar
P
P
Viswanathan
P N
PN
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000494:pharmacology*; D014969:Xanthine Oxidase / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D008081:Liposomes; D010743:Phospholipids; D016718:Arachidonic Acid; D006861:Hydrogen Peroxide; D007501:Iron; D014969:Xanthine Oxidase; D013095:Spermidine