[The effect of low-dose acetylsalicylic acid on platelet aggregation parameters in vitro].
In order to elucidate whether a single dose of 150 mg acetylsalicylic acid three times a day, provokes significant changes into platelet aggregation, we analyzed a group of 50 patients who underwent coronary revascularization. During 48 hours before surgery, all patients received 100 mg dipyridamole orally every 6 hours and 1 hour after the end of the operation 100 mg dipyridamole via nasogastric tube. Patients were then randomized into three groups to receive 3 times a day a capsule containing: 50 mg acetylsalicylic acid, 50 mg acetylsalicylic acid plus 75 mg dipyridamole or placebo. Before the antiplatelet therapy was started, the day of the operation and 5 days after the onset of the treatment, blood samples were taken to determine platelet aggregation (turbidimetric technique) and the thromboxane A2 liberation. The three groups were comparable for all the studied clinical and angiographic variables. Preoperative dipyridamole did not provoke significant changes in platelet aggregation (acetylsalicylic acid group 86.5 +/- 10% vs 71 +/- 28.8%; acetylsalicylic acid + dipyridamole group 81.5 +/- 7.8% vs 75.3 +/- 22.7%; placebo group 83.7 +/- 8.9% vs 70 +/- 21.5%). After 5 days of treatment with acetylsalicylic acid, both groups under active treatment showed a significant (p less than 0.001) decrease of aggregability (acetylsalicylic acid 12.8 +/- 4.4%; acetylsalicylic acid + dipyridamole 20.5 +/- 17%; placebo 72 +/- 21.5%).(ABSTRACT TRUNCATED AT 250 WORDS)
Cardona
M
M
Servicio de Cardiología y Unidad Coronaria, Hospital Clínic i Provincial, Universidad de Barcelona.
Escolar
G
G
Roig
E
E
Bastida
E
E
Ordinas
A
A
Sanz
G
G
D001241:Aspirin / Q000008:administration & dosage*; D004176:Dipyridamole / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011300:Preoperative Care; D013928:Thromboxane A2 / Q000032:analysis; D013997:Time Factors
D013928:Thromboxane A2; D004176:Dipyridamole; D001241:Aspirin
Efecto del ácido acetilsalicílico a dosis bajas sobre los parámetros de agregación plaquetaria in vitro.