title: Upper oesophageal sphincter pressure and the intravenous induction of anaesthesia.
abstract: The upper oesophageal sphincter can prevent regurgitation of oesophageal contents into the pharynx following gastrooesophageal reflux in the awake patient. Upper oesophageal sphincter pressure was recorded with a Dent sleeve after hypnosis with midazolam (n = 7) and also during the rapid intravenous induction of anaesthesia with thiopentone (n = 16) or ketamine (n = 7). Thiopentone decreased mean (SD) sphincter pressure from an awake value of 43 (19) to 9 (7) mmHg (p less than 0.001) and midazolam from 38 (25) to 7 (3) mmHg (p less than 0.02). Mean (SD) sphincter pressures before and after ketamine were not significantly different at 29 (15) and 32 (21) mmHg respectively. After suxamethonium mean (SD) sphincter pressure in all patients (n = 30) was 7 (4) mmHg. Laryngoscopy (n = 30) caused a small increase in mean (SD) sphincter pressure to 13 (10) mmHg (p less than 0.001). Thiopentone caused a rapid fall in upper oesophageal sphincter pressure which usually started before loss of consciousness. These findings have implications for the timing of cricoid pressure application.
authors.affiliation: Department of Anaesthetics, St Thomas' Hospital, London.
authors.forename: R G
authors.initials: RG
authors.lastname: Vanner
authors.forename: B J
authors.initials: BJ
authors.lastname: Pryle
authors.forename: J P
authors.initials: JP
authors.lastname: O'Dwyer
authors.forename: F
authors.initials: F
authors.lastname: Reynolds
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D003413:Cricoid Cartilage / Q000502:physiology; D004947:Esophagus / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D007649:Ketamine; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D011312:Pressure; D013390:Succinylcholine; D013874:Thiopental
chemical_list: D007649:Ketamine; D013390:Succinylcholine; D013874:Thiopental; D008874:Midazolam