title: Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome.
abstract: A member of the cytochrome P450 superfamily has been identified within region 2D of the Drosophila X chromosome. The sequence of this gene shows strongest homology with P450 family 4 genes, and has thus been named CYP4D1 in accordance with convention. This P450 gene is expressed throughout Drosophila development, with the highest levels of transcript accumulation occurring during late larval stages. A fragment of Drosophila genomic DNA including the CYP4D1 gene has been reintroduced into the germ line by P-element-mediated transformation. This transduced fragment does not rescue any of the lethal mutations that have been identified in this genetically well-characterized region of the Drosophila genome.
authors.affiliation: Section of Genetics and Development, Cornell University, Ithaca, NY 14853-2703.
authors.forename: R
authors.initials: R
authors.lastname: Gandhi
authors.forename: E
authors.initials: E
authors.lastname: Varak
authors.forename: M L
authors.initials: ML
authors.lastname: Goldberg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D015870:Gene Expression; D005796:Genes; D005816:Genetic Complementation Test; D008969:Molecular Sequence Data; D005810:Multigene Family; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D016415:Sequence Alignment
chemical_list: D012333:RNA, Messenger; D003577:Cytochrome P-450 Enzyme System