title: Intravascular pancuronium bromide infusion for prenatal diagnosis of twin-twin transfusion syndrome.
abstract: The diagnosis of twin-twin transfusion syndrome remains a problem. Intravascular infusion of pancuronium bromide, a nondepolarizing neuromuscular blocking agent, for the smaller of a set of twins demonstrated paralysis of both twins in one case. However, in a second case, paralysis was shown only in the smaller twin who demonstrated no transplacental vascular communications postnatally. We suggest that infusion of pancuronium bromide, 'pancuronium test', is a simple and safe method for confirming transplacental communications and aids in the diagnosis of twin-twin transfusion syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Natori
authors.forename: H
authors.initials: H
authors.lastname: Ishimoto
authors.forename: H
authors.initials: H
authors.lastname: Kohno
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Nozawa
mesh_terms: D000328:Adult; D005260:Female; D005330:Fetofetal Transfusion / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D006340:Heart Rate, Fetal / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D053685:Laser Therapy; D008297:Male; D010197:Pancuronium / Q000008:administration & dosage; D010920:Placenta / Q000098:blood supply / Q000601:surgery; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D010197:Pancuronium