Effects of sodium meclofenamate on postoperative pain following periodontal surgery.
The analgesic activity of single doses of meclofenamate (100 mg) was compared to aspirin (500 mg) and to placebo on 99 outpatients with moderate to severe pain following periodontal surgery under double-blind conditions. Pain intensity differences scores (PID) at the first, second, and third hour after the ingestion of the first capsule of each medication were used to determine the analgesic efficacy of the studied drugs. Kruskal Wallis test followed by the Mann-Whitney rank sum test were used in the statistical analysis of results. Meclofenamate was statistically superior to placebo and superior to aspirin in the second hour of evaluation, while aspirin was not superior to placebo during the 3-hour period of pain evaluation. It is concluded that meclofenamate is a non-steroidal antiinflammatory drug with interesting analgesic properties which can be used as directed as an alternative to aspirin or acetaminophen for the control of postoperative pain following periodontal surgery.
Gallardo
F
F
Department of Pharmacology, School of Medicine, University of Chile, Santiago.
Rossi
E
E
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008469:Meclofenamic Acid / Q000627:therapeutic use*; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010510:Periodontal Diseases / Q000601:surgery*; D010919:Placebos; D013524:Surgical Flaps / Q000379:methods; D013997:Time Factors
D010919:Placebos; D008469:Meclofenamic Acid; D001241:Aspirin