title: Mechanical alteration of blood flow in smoked and unsmoked lung areas after inhalation injury.
abstract: The degree of pulmonary perfusion may have an important role in the pathogenesis of inhalation injury. We studied this in sheep that had only one lung exposed to smoke. The right lung and upper airway of 12 chronically instrumented sheep were insufflated with cotton smoke. In six animals, the left pulmonary artery was occluded between 4 and 10 h after smoke insufflation. All animals were studied for 24 h and then killed, and lung tissue was harvested. The smoked as well as the air-insufflated lung of all animals showed an increase in wet-to-dry weight ratio and tissue conjugated dienes (products of lipid peroxidation). Neither the intermittent blood flow increase to the smoked lung nor the simultaneous blood flow reduction with a concomitant polymorphonuclear neutrophil entrapment in the air-insufflated lung significantly affected the histopathological outcome of the respective lung. We conclude that tissue damage after inhalation injury cannot be diminished by increasing the flow to smoked areas. Ischemia-reperfusion injury does not have a major role in the lung damage seen with inhalation injury.
authors.affiliation: Department of Anesthesiology, University of Texas Medical Branch, Galveston.
authors.forename: H M
authors.initials: HM
authors.lastname: Loick
authors.forename: L D
authors.initials: LD
authors.lastname: Traber
authors.forename: R
authors.initials: R
authors.lastname: Tokyay
authors.forename: H A
authors.initials: HA
authors.lastname: Linares
authors.forename: T
authors.initials: T
authors.lastname: Prien
authors.forename: D L
authors.initials: DL
authors.lastname: Traber
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D005260:Female; D015227:Lipid Peroxidation; D008168:Lung / Q000098:blood supply / Q000473:pathology; D055370:Lung Injury; D009504:Neutrophils / Q000473:pathology; D011652:Pulmonary Circulation / Q000502:physiology*; D015427:Reperfusion Injury / Q000209:etiology; D012756:Sheep; D015208:Smoke Inhalation Injury / Q000473:pathology / Q000503:physiopathology*