Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats.
A survey programme was organised in Lucknow and Farrukhabad, two towns of Uttar Pradesh, from March 1987 to July 1987. During the survey, the common folk medicine plants used by women were recorded and Ayurvedic and Unani drug encyclopedias were consulted for the antireproductive potential of these plants. Aqueous or 90% ethanol extracts of the plants of interest were studied in rats orally dosed for 10 days after insemination with special reference to effects on foetal development. Leaf extracts of Moringa oleifera and Adhatoda vasica were 100% abortive at doses equivalent to 175 mg/kg of starting dry material. Only the flowers of Acacia arabica and Hibiscus rosa-sinensis appeared to lack teratologic potential at the doses tested.
Nath
D
D
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
Sethi
N
N
Singh
R K
RK
Jain
A K
AK
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000019:Abortifacient Agents / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D005260:Female; D007194:India; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D051381:Rats
D000019:Abortifacient Agents; D010936:Plant Extracts; D000431:Ethanol