title: Pharmacokinetics of butorphanol tartrate in rabbits.
abstract: The pharmacokinetic properties of butorphanol tartrate were determined in 7 rabbits after IV and SC injection (0.5 mg/kg of body weight). A 2-compartment model (biexponential) best represented the concentration vs time curve after IV injection. The half-life was calculated to be 1.64 hours via IV administration, whereas SC injection resulted in an elimination half-life of 3.16 hours.
authors.affiliation: Johns Hopkins University, Division of Comparative Medicine, Baltimore, MD 21205.
authors.forename: L G
authors.initials: LG
authors.lastname: Portnoy
authors.forename: D R
authors.initials: DR
authors.lastname: Hustead
mesh_terms: D000818:Animals; D002077:Butorphanol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D011817:Rabbits / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D002077:Butorphanol