title: Ki67 immunoreactivity in breast carcinoma: relationships to prognostic variables and short term survival.
abstract: Immunoreactivity of the monoclonal antibody Ki67, which recognizes an antigen expressed in cells active in the cell cycle, has been investigated by immunocytochemistry in a series of 67 primary breast cancers. The percentage of tumour cell nuclei stained by Ki67 (labelling index) was related to tumour histological grade, mitotic frequency, oestrogen receptor status and tumour type. No correlation was found with patient age, tumour size or lymph node stage. A high Ki67 labelling index was significantly associated with diminished patient survival and disease-free interval, which demonstrates an important role for this monoclonal antibody as a prognostic marker in breast cancer.
authors.affiliation: Nottingham City Hospital, Cardiff, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: Locker
authors.forename: K
authors.initials: K
authors.lastname: Birrell
authors.forename: J A
authors.initials: JA
authors.lastname: Bell
authors.forename: R I
authors.initials: RI
authors.lastname: Nicholson
authors.forename: C W
authors.initials: CW
authors.lastname: Elston
authors.forename: R W
authors.initials: RW
authors.lastname: Blamey
authors.forename: I O
authors.initials: IO
authors.lastname: Ellis
mesh_terms: D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D002455:Cell Division; D016009:Chi-Square Distribution; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019394:Ki-67 Antigen; D015993:Life Tables; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009687:Nuclear Proteins