[Hypophyseal dysfunction and tumors].
Some pituitary hormones secrete hormones while others do not. Nonsecreting tumors can interfere with normal pituitary hormone secretion and produce tumor symptoms and signs like headaches and visual field defects. The most frequent hormone-secreting tumors are prolactinomas. Growth hormone or ACTH or gonadotropin or gonadotropin-alpha and beta chain-producing tumors are less frequent, TSH producing tumors are extremely rare. The most important elements of the diagnostic work-up are clinical signs and symptoms, assessment of pituitary function (measurement of TSH, free T4, LH, FSH, oestradiol/free testosteron, growth hormone, IGF-1, prolactin, ACTH, Cortisol, serum and urine osmolality), CT and/or MRI and, in patients with large tumors, a visual field exam. The treatment of choice of pituitary tumors is often surgery. Alternative therapies are radiation treatment (in nonoperable patients or when hormone levels are persistently elevated after pituitary surgery) and drug treatment (dopamine agonists in hyperprolactinemia, somatostatin analogues in acromegaly). Pituitary hormone deficiencies are treated depending on the specific deficiency with thyroxine, cortisone, oestrogen/gestagen/testosterone gonadotropines or ADH analogues.
Bürgi
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U
Abteilung für Endokrinologie und Diabetologie, Inselspital, Bern.
Seiler
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R
D000236:Adenoma / Q000175:diagnosis* / Q000503:physiopathology; D000818:Animals; D006224:Cricetinae; D006801:Humans; D007016:Hypophysectomy; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis* / Q000503:physiopathology; D010901:Pituitary Function Tests; D010902:Pituitary Gland / Q000503:physiopathology; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000503:physiopathology
Hypophysendysfunktion und-tumoren.