Clinical uses and advantages of low doses of benzodiazepine hypnotics.
The most common adverse effects associated with the use of benzodiazepine hypnotics are residual daytime effects (daytime sedation and daytime performance decrements), anterograde amnesia, and rebound insomnia. Studies show that these adverse effects are related to dose. Hence, benzodiazepine hypnotics should be used in low doses so as to minimize or prevent these common adverse effects. It is now generally accepted that benzodiazepines should not be administered long-term for the treatment of chronic "idiopathic" insomnia. Two noncontinuous sleep disturbances, insomnia in the elderly and transient insomnia in young and middle-aged adults, are probably the most acceptable indications for the use of benzodiazepines. Low doses of short- and intermediate-acting benzodiazepines (triazolam and temazepam) are efficacious in the treatment of insomnia in the elderly, and preliminary evidence suggests that they are efficacious in the treatment of transient insomnia in young and middle-aged adults.
Vogel
G
G
Sleep Laboratory, Emory University School of Medicine, Atlanta, GA 30306.
D000328:Adult; D000368:Aged; D000647:Amnesia / Q000139:chemically induced; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005479:Flurazepam / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D012890:Sleep / Q000187:drug effects; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced / Q000188:drug therapy*; D013693:Temazepam / Q000008:administration & dosage / Q000009:adverse effects; D014229:Triazolam / Q000008:administration & dosage / Q000009:adverse effects
D001569:Benzodiazepines; D014229:Triazolam; D013693:Temazepam; D005479:Flurazepam