Prevention of stress gastritis with tissue preservation solution.
Stress gastritis frequently occurs in association with shock or sepsis. Gastric mucosal ischemia appears to be a key feature in these critically ill patients. The University of Wisconsin cold preservation solution (UWS) is an isoosmolar, nonglucose-based perfusate that minimizes hypothermia-induced cell swelling and prevents intracellular acidosis and oxygen-free radical injury, while providing high energy substrates for donor organs. In a prospective, single-blind study, 18 similar Sprague-Dawley rats were randomly divided to receive only 5 per cent dextrose and water (D5W) (Group 1) or a 50 per cent solution of D5W+UWS (Group 2) for 72 hours. At the end of 72 hours the animals were stressed by the cold-restraint model. The mean number of ulcers for Group 2 was nearly half that of Group 1. Also, Group 2 had a significantly lower mean total ulcer length (P less than 0.005) and ulcer index (P less than 0.05). Most of Group 2 had mild gastritis changes (grade 0 to 1), while more than half of Group 1 had severe gastritis (grade 3). Gastric mucosal pH was similar for both groups. Topically applied UWS appears to reduce the severity and incidence of stress gastritis in this experimental model. Because mucosal pH values were similar, it is thought that UWS may alter the effects of gastric mucosal ischemia at a cellular level.
Fenton
A H
AH
Department of Surgery, Northeastern Ohio University, College of Medicine, Akron.
Clark
T W
TW
Meyer
M S
MS
Moorman
D W
DW
D000241:Adenosine; D000284:Administration, Oral; D000493:Allopurinol; D000818:Animals; D002314:Cardioplegic Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000473:pathology / Q000517:prevention & control*; D006471:Gastrointestinal Hemorrhage / Q000473:pathology / Q000517:prevention & control; D005947:Glucose / Q000008:administration & dosage / Q000627:therapeutic use; D005978:Glutathione; D006863:Hydrogen-Ion Concentration; D007328:Insulin; D008297:Male; D019188:Organ Preservation Solutions; D011446:Prospective Studies; D011887:Raffinose; D051381:Rats; D011919:Rats, Inbred Strains; D016037:Single-Blind Method; D012996:Solutions / Q000008:administration & dosage / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000473:pathology / Q000517:prevention & control; D013312:Stress, Physiological / Q000150:complications*; D014021:Tissue Preservation
D002314:Cardioplegic Solutions; D007328:Insulin; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D005947:Glucose; D000241:Adenosine; D011887:Raffinose