title: Synthesis of a new organic pyrophosphate in large quantities is induced in some bacteria by oxidative stress.
abstract: Brevibacterium ammoniagenes and Micrococcus luteus were shown to synthesize up to 50 mM of a novel substance, 2-methylbutan-1,2,3,4-tetraol 2,4-cyclopyrophosphate, in response to oxidative stress created by benzyl viologen and other redox mediators under aerobic conditions. The substance, which represents greater than 50% of the extractable phosphorus, is suggested to play a role as a bacterial antistressor and is thought to be a product of condensation of two molecules of phosphoenolpyruvate whose accumulation is prompted by conversion of intracellular NADPH into an oxidized form.
authors.affiliation: Bakh Institute of Biochemistry, Moscow, Russia.
authors.forename: D
authors.initials: D
authors.lastname: Ostrovsky
authors.forename: E
authors.initials: E
authors.lastname: Kharatian
authors.forename: I
authors.initials: I
authors.lastname: Malarova
authors.forename: I
authors.initials: I
authors.lastname: Shipanova
authors.forename: L
authors.initials: L
authors.lastname: Sibeldina
authors.forename: A
authors.initials: A
authors.lastname: Shashkov
authors.forename: G
authors.initials: G
authors.lastname: Tantsirev
mesh_terms: D001951:Brevibacterium / Q000378:metabolism*; D004896:Erythritol / Q000031:analogs & derivatives*; D016982:Micrococcus luteus / Q000378:metabolism*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D009943:Organophosphorus Compounds; C073443:2-methyl-butan-1,2,3,4-tetraol-2,4-cyclopyrophosphate; D004896:Erythritol