Fluoride availability in human saliva after dentifrice use: correlation with anticaries effects in rats.
Studies were conducted to determine fluoride availability in saliva after dentifrice use and to relate this parameter to cariostatic efficacy in rat caries experiments. Three dentifrices--two commercial formulations (Colgate Winterfresh Gel and Crest Dentifrice with Na-Sr-polyacrylate) and an Experimental dentifrice--were compared with respect to salivary fluoride availability. All of the dentifrices tested contained 1100 ppm F as sodium fluoride. It was observed that the Experimental dentifrice and Crest dentifrice with Sr-polyacrylate exhibited low salivary fluoride availability relative to the Colgate Winterfresh Gel. Salivary fluoride availability was assessed by means of two parameters: (a) the fluoride concentration in the dentifrice saliva slurry expectorated after brushing, and (b) the area under the curve of salivary F concentration vs. time for up to two hours after dentifrice use. In two rat caries experiments, it was observed that both the Experimental dentifrice and the Sr-polyacrylate dentifrice provided less cariostatic efficacy than the clinically validated Positive Control (Colgate Winterfesh Gel). Analysis of these data provides further evidence in support of the concept that fluoride availability in saliva following dentifrice use is an important parameter related to anticaries efficacy.
Afflitto
J
J
Colgate-Palmolive Company, Corporate Technology Center, Piscataway, New Jersey 08855.
Schmid
R
R
Esposito
A
A
Toddywala
R
R
Gaffar
A
A
D000180:Acrylic Resins / Q000627:therapeutic use; D000328:Adult; D000818:Animals; D001682:Biological Availability; D002327:Cariostatic Agents / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D010919:Placebos; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D013324:Strontium / Q000627:therapeutic use; D013997:Time Factors
D000180:Acrylic Resins; D002327:Cariostatic Agents; D003802:Dentifrices; D010919:Placebos; C006903:carbopol 940; D012969:Sodium Fluoride; D005459:Fluorides; D013324:Strontium