title: A comparison of tenoxicam and piroxicam in the treatment of rheumatoid arthritis.
abstract: Tenoxicam 20 mg OD was compared with piroxicam 20 mg OD for patients with rheumatoid arthritis (RA). One hundred and two patients from 5 centers were enrolled: 51 in the tenoxicam group and 51 in the piroxicam group. Evaluation of the primary efficacy variables demonstrated no difference in efficacy between treatment groups. The overall incidence of adverse clinical/laboratory experiences was similar between treatment groups. Six patients discontinued the study because of gastrointestinal intolerance, 3 from each treatment group. Our study demonstrates that tenoxicam 20 mg OD and piroxicam 20 mg OD have similar efficacy and safety in patients with active RA.
authors.affiliation: Faculty of Medicine, University of Calgary, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Atkinson
authors.forename: V
authors.initials: V
authors.lastname: Khanna
authors.forename: H
authors.initials: H
authors.lastname: Ménard
authors.forename: A S
authors.initials: AS
authors.lastname: Russel
authors.forename: H
authors.initials: H
authors.lastname: Tannenbaum
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002493:Central Nervous System Diseases / Q000139:chemically induced; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D008875:Middle Aged; D010894:Piroxicam / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C032801:tenoxicam