Recombinant globulins: novel research tools and possible pharmaceuticals.
A novel approach to the study of proteins is the construction of chimeras consisting of a target protein fused to an immunoglobulin constant domain. These recombinant globulins have been used in the identification of ligand-receptor pairs, determination of functional consequences of receptor engagement, the elucidation of structural domains necessary for ligand binding, and as potential therapeutic agents.
Hollenbaugh
D
D
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington.
Chalupny
N J
NJ
Aruffo
A
A
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002678:Chimera / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D008024:Ligands; D011993:Recombinant Fusion Proteins / Q000276:immunology; D012106:Research; D013329:Structure-Activity Relationship
D000911:Antibodies, Monoclonal; D007136:Immunoglobulins; D008024:Ligands; D011993:Recombinant Fusion Proteins