title: Preservation of the anomeric specificity of glucose-induced insulin release in partially pancreatectomized rats.
abstract: Attenuation, suppression or even inversion of the normal preference of glucose-stimulated insulin release for the alpha-anomer of the hexose was recently proposed to represent a feature of Beta-cell glucotoxicity in Type 2 (non-insulin-dependent) diabetes mellitus. Since recent reports emphasize the possible significance of Beta-cell secretory hyperactivity as a determinant of such a glucotoxicity, the anomeric specificity of glucose-induced insulin release was examined in normoglycaemic partially pancreatectomized rats. About 80-85% of the pancreas was removed, the animals then being given sucrose via their drinking water up to the time of killing. In these animals, alpha-D-glucose was more efficient than beta-D-glucose in stimulating insulin release from the perfused pancreas, the alpha/beta ratio in insulin output not being significantly different from that found in control rats. It is concluded, therefore, that the anomeric malaise, taken as a manifestation of Beta-cell glucotoxicity, it attributable to hyperglycaemia rather than to Beta-cell secretory hyperactivity.
authors.affiliation: Laboratory of Experimental Medicine, Erasmus Medical School, Brussels Free University, Belgium.
authors.forename: V
authors.initials: V
authors.lastname: Leclercq-Meyer
authors.forename: F
authors.initials: F
authors.lastname: Malaisse-Lagae
authors.forename: V
authors.initials: V
authors.lastname: Coulic
authors.forename: A G
authors.initials: AG
authors.lastname: Akkan
authors.forename: J
authors.initials: J
authors.lastname: Marchand
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D010180:Pancreatectomy; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose