title: Helicobacter pylori infection: comparison among four different therapeutic regimens.
abstract: Helicobacter pylori is both virulent and pathogenic, yet it is not clear what is the best way to treat the infection. This study compares the ability of 4 regimens of colloidal bismuth subcitrate (CBS) 120 mg q.i.d. for 4 weeks, combined with one or two antibiotics, to eradicate helicobacter pylori and assesses the outcome of eradication on antral gastritis and on symptoms of non-ulcer dyspepsia in 140 consecutive subjects (44 duodenal ulcers and 96 non ulcer dyspepsia). Endoscopy with antral biopsies was repeated in all patients before (T0) and one month after stopping treatments (T2) while duodenal ulcers were endoscoped also at the completion of treatments (T1). The four regimens showed similar eradication and ulcer healing rates (p = ns). After treatments (T1), about 60% of dyspeptic patients achieved a subjective improvement, not significant despite therapeutic regimen, and persisting at T2. Antral gastritis significantly improved after treatments (p less than 0.0001), even with the persistence of the infection (p less than 0.001). The 4 regimens are relatively safe, as no abnormality in laboratory assessment was found, albeit the frequency of side effects (most of whom tinidazole related) and the difficulty of the schedules (6-10 tablets/day) may limit patient compliance.
authors.affiliation: Dipartimento di Fisiopatologia Clinica, Università degli Studi di Torino, Ospedale Civile, Italy, Rome.
authors.forename: E
authors.initials: E
authors.lastname: Bologna
authors.forename: M
authors.initials: M
authors.lastname: Stroppiana
authors.forename: S
authors.initials: S
authors.lastname: Peyre
authors.forename: R
authors.initials: R
authors.lastname: Rizzi
authors.forename: C
authors.initials: C
authors.lastname: Sategna-Guidetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D007074:Immunoglobulin G; D009942:Organometallic Compounds; C002791:bismuth tripotassium dicitrate