title: Presence of class II histocompatibility DR proteins on the envelope of human immunodeficiency virus demonstrated by FACS analysis.
abstract: Depending on the cell line used for virus propagation, human immunodeficiency virus (HIV) particles may possess class II MHC proteins, as demonstrated by FACS analysis. HLA-DR appeared in high amounts at the HIV envelope, if the virus was grown in HLA-DR+ cells, but was absent if the virus had been grown in HLA-DR- cells. No other cellular constituents, including HLA-DQ and HLA-DP, were detected in these virions. The presence of HLA-DR in the virion envelope itself in preparations used for diagnostic purposes may explain some of the false-positive results obtained in earlier serological tests for HIV infection. Possible implications of these virus-associated cellular antigens in the immunopathogenesis of AIDS should be considered.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Schols
authors.forename: R
authors.initials: R
authors.lastname: Pauwels
authors.forename: J
authors.initials: J
authors.lastname: Desmyter
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D002478:Cells, Cultured; D005434:Flow Cytometry / Q000379:methods; D006678:HIV / Q000737:chemistry*; D015658:HIV Infections / Q000378:metabolism*; D015497:HIV-1 / Q000737:chemistry; D015498:HIV-2 / Q000737:chemistry; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D014759:Viral Envelope Proteins / Q000032:analysis*
chemical_list: D006684:HLA-DR Antigens; D014759:Viral Envelope Proteins