title: Treatment of 46 patients with Turner's syndrome with recombinant human growth hormone (YM-17798) for three years: a multicentre study.
abstract: A total of 46 patients with Turner's syndrome were treated for three years with recombinant hGH. Nineteen patients received hGH at a weekly dosage of 0.5 IU.kg-1.week-1, while 27 received 1.0 IU.kg-1.week-1 by daily sc injection. Both treatment groups showed a statistically significant growth increase during treatment. The increase in height over three years' treatment, as expressed by SD score (SDS) for chronological age, did not differ significantly between patients treated with 0.5 IU and those with 1.0 IU hGH. Seventeen of 22 patients over the age of 14 had exceeded their expected adult height. Plasma IGF-1 levels were elevated and no remarkable advances in bone age were observed during the treatment in either treatment group. There were no other significant changes in physical or laboratory examinations. No glucose intolerance was observed. These results indicate that hGH treatment is useful for accelerating growth velocity in patients with Turner's syndrome. However, further study will be required to find the best treatment dosage.
authors.affiliation: Department of Medicine, Tokyo Women's Medical College.
authors.forename: K
authors.initials: K
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Shizume
authors.forename: I
authors.initials: I
authors.lastname: Hibi
mesh_terms: D000293:Adolescent; D001846:Bone Development; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006128:Growth; D013006:Growth Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019382:Human Growth Hormone; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D013997:Time Factors; D014424:Turner Syndrome / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D011994:Recombinant Proteins; C074840:YM 17798; D019382:Human Growth Hormone; D013006:Growth Hormone