Free radicals in myocardial injury: experimental and clinical studies.
The exposure of cardiac cells to OFR generated artificially, showed a marked decrease (p less than 0.01) in cellular utilization of glucose along with a significant decrease in calcium uptake (p less than 0.05). We have also provided evidence for a direct relationship of neutrophil OFR production with the extent of myocardial ischemia in patients of myocardial infarction. Our data provides evidence for implication of OFR in myocardial injury and the pivotal role played by modulators like calcium, ECGF and prostaglandins in potentiating damage to the myocardium.
Ganguly
N K
NK
Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Nalini
K
K
Wahi
S
S
Dhawan
V
V
Meenakshi
S
S
Chakravarti
R N
RN
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D000368:Aged; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003324:Coronary Artery Disease / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000494:pharmacology; D005260:Female; D005609:Free Radicals / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism
D016228:Endothelial Growth Factors; D005609:Free Radicals; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D005947:Glucose; D010100:Oxygen; D002118:Calcium; D007213:Indomethacin