Behavioral sequelae in young rats of acute intermittent antenatal hypoxia.
Several studies have examined behavioral sequelae of acute or chronic pre- or postnatal hypoxia. However, few of these tested a large battery of behavioral functions, particularly those following relatively mild, intermittent hypoxia. Also, in few studies were the hypoxic pups cross-fostered or the experimenter blinded as to experimental group. In addition, in almost no studies were concomitant hypoxic-induced brain biochemicals measured. The present study tested the hypotheses that mild, intermittent antenatal hypoxia can lead to long-term alterations in neurobehavioral development, as well as neurochemical changes.
Hermans
R H
RH
Department of Physiology, Loma Linda University, School of Medicine, CA 92350.
Hunter
D E
DE
McGivern
R F
RF
Cain
C D
CD
Longo
L D
LD
D000818:Animals; D001362:Avoidance Learning; D001835:Body Weight; D001921:Brain / Q000196:embryology / Q000201:enzymology; D002531:Cerebellum / Q000201:enzymology; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology* / Q000523:psychology; D005684:Gait; D006624:Hippocampus / Q000201:enzymology; D008297:Male; D009043:Motor Activity; D009955:Ornithine Decarboxylase / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex; D012727:Sex Characteristics; D012741:Sexual Maturation; D013239:Stereotyped Behavior
D009955:Ornithine Decarboxylase