title: Fetal and neonatal cerebral circulation: a pulsed Doppler study.
abstract: We studied the relation between the fetal cerebral circulation and changes in the cerebral circulation directly after birth. With a combined real time ultrasound/pulsed Doppler technique flow velocity waveforms from the fetal umbilical- and carotid-circulation were monitored. Pulsatility Index (PI) was computed and the ratio between Umbilical PI and Carotid PI was calculated. Flow velocity waveforms of the cerebral circulation before birth were related to anterior cerebral artery flow velocity waveforms recorded immediately after birth. The study shows that changes in flow velocity waveforms associated with the intra uterine brain-sparing effect are related to poor obstetrical outcome. Furthermore is shown that the brain-sparing effect in the fetal period is associated with higher PI values in the cerebrovascular circulation in the neonatal period. It is suggested that changes in these PI values, representing changes in cerebrovascular resistance, might be indicative of cerebral ischemia in the neonate.
authors.affiliation: Department of Obstetrics, University of Amsterdam, The Netherlands.
authors.forename: S A
authors.initials: SA
authors.lastname: Scherjon
authors.forename: J H
authors.initials: JH
authors.lastname: Kok
authors.forename: H
authors.initials: H
authors.lastname: Oosting
authors.forename: H
authors.initials: H
authors.lastname: Wolf
authors.forename: H A
authors.initials: HA
authors.lastname: Zondervan
mesh_terms: D002339:Carotid Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D011247:Pregnancy; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000503:physiopathology