title: [Pharmacokinetics of 5-fluorouracil in erythrocytes following i.v. administration].
abstract: The in vivo binding of the antineoplastic agent 5-fluorouracil (1) to erythrocytes in the whole blood of patients was investigated. The vascular availability of 1 is influenced by erythrocytes at 38.6 +/- 7.2% (calculated as AUC0-60-values), the coefficient of partition is 0.65 +/- 0.18. In comparison with serum, the volume of distribution and the total clearance are elevated by the erythrocytes, the half-lives of the compartment distribution and of the terminal elimination are not influenced.
authors.affiliation: Institut für Pharmazeutische Chemie, Universität Wien, Osterreich.
authors.forename: M
authors.initials: M
authors.lastname: Czejka
authors.forename: J
authors.initials: J
authors.lastname: Schüller
authors.forename: U
authors.initials: U
authors.lastname: Fogl
mesh_terms: D004912:Erythrocytes / Q000378:metabolism*; D005472:Fluorouracil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged
chemical_list: D005472:Fluorouracil
vernacular_title: Pharmakokinetik von 5-Fluorouracil nach i.v.-Gabe unter Berücksichtigung der Erythrozyten.