[Change in congener analysis caused by percutaneous absorption of propanol-containing antiseptics].
According to the forensic literature, an alteration of blood alcohol concentration through alcohol disinfection before venepuncture is unlikely, however, percutaneous resorption of alcohol containing antiseptics is well documented. There are no investigations available, elucidating to what extent this is also correct for congener alcohols, particularly propanol-1/-2, which have serum levels in range of mg/l. In experiments with surgical hand and local skin disinfection, carried out with and without oral alcohol, relevant levels of propanol-1/-2 between 0.2 and 2 mg/l were measured. We conclude, that the routine clinical use of antiseptics is able to alterate and to falsify congener levels and can lead to incorrect interpretation of congener analysis.
Peschel
O
O
Institut für Rechtsmedizin Universität München.
Bauer
M F
MF
Gilg
T
T
Meyer
L V
LV
von Meyer
L
L
D000433:1-Propanol / Q000493:pharmacokinetics*; D000428:Alcohol Drinking / Q000097:blood*; D000891:Anti-Infective Agents, Local / Q000493:pharmacokinetics*; D001800:Blood Specimen Collection; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D012869:Skin Absorption / Q000502:physiology
D000891:Anti-Infective Agents, Local; D000431:Ethanol; D000433:1-Propanol
Veränderung von Begleitstoffanalysen durch percutane Resorption propanolhaltiger Antiseptika.