title: [Description of 2 patients with cytogenetically abnormal clones].
abstract: We present two patients with two cytogenetically unrelated clones. A patient was diagnosed of refractory anaemia and showed an abnormal clone with trisomy 8 and other clone with 5q-; the other patient, diagnosed as chronic lymphocytic leukaemia showed a clone with an inversion of chromosome 2, inv(2) (p23q12) and the other clone with a 47,XX,+5,t(16;17)(p13;q11),+2ac karyotype. The discussion is focused on the presence of unrelated clones in relation to the monoclonal origin of cancer.
authors.affiliation: Departamento de Hematología y Oncología, Hospital Central L'Aliança, Barcelona.
authors.forename: F
authors.initials: F
authors.lastname: Solé
authors.forename: S
authors.initials: S
authors.lastname: Woessner
authors.forename: A
authors.initials: A
authors.lastname: Pérez
authors.forename: L
authors.initials: L
authors.lastname: Florensa
authors.forename: C
authors.initials: C
authors.lastname: Besses
authors.forename: J
authors.initials: J
authors.lastname: Sans Sabrafén
mesh_terms: D000368:Aged; D000753:Anemia, Refractory / Q000235:genetics*; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D015461:Leukemia, Prolymphocytic, T-Cell / Q000235:genetics*
vernacular_title: Descripción de dos pacientes con clones citogenéticamente anormales.