title: Dupuytren's and epilepsy revisited.
abstract: The incidence of Dupuytren's disease amongst the residents of two epileptic centres was found to be 12.0% in one and 38.1% in the other. The overall incidence at the second was significantly higher than a control population (16.0%) and this difference was particularly apparent in patients over 50 years old. The distribution of the Dupuytren's disease was found to be very similar to that of non-epileptic patients. At both centres, the disease process was more severe, with an increased incidence of contractures. Drug therapy was not clearly implicated in the aetiology of this condition.
authors.affiliation: Department of Orthopaedic Surgery, University of Manchester and Hope Hospital, Salford.
authors.forename: M
authors.initials: M
authors.lastname: Arafa
authors.forename: J
authors.initials: J
authors.lastname: Noble
authors.forename: S G
authors.initials: SG
authors.lastname: Royle
authors.forename: I A
authors.initials: IA
authors.lastname: Trail
authors.forename: J
authors.initials: J
authors.lastname: Allen
mesh_terms: D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects; D004387:Dupuytren Contracture / Q000139:chemically induced / Q000453:epidemiology*; D004739:England / Q000453:epidemiology; D004827:Epilepsy / Q000453:epidemiology*; D005260:Female; D005385:Fingers / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D000927:Anticonvulsants; D010634:Phenobarbital