title: Types and causes of pain in cancer of the head and neck.
abstract: In a series of 25 patients with head and neck cancer who had severe pain, the type and cause of the pain were analyzed. There were two types of pain: nociceptive and non-nociceptive. Nineteen (76%) patients had nociceptive pain that could be subdivided into actual nociceptive pain (9 patients), nociceptive nerve pain (8 patients), or referred pain (2 patients). The cause of nociceptive pain was secondary to tumor recurrence in 16 patients and secondary to benign inflammation in 3 patients. Of the six (23%) cases of non-nociceptive pain, all were diagnosed as neuropathic pain secondary to the sequels of neck dissection. World Health Organization guidelines were applied for the treatment of symptomatic pain of nociceptive pain; if necessary, nerve blocks were used after this treatment. Non-nociceptive pain was usually treated with amitriptyline or carbamazepine. If tumor recurrence was the cause of the pain, antitumor-directed therapy was applied, when possible. Relief was achieved in 52% of the patients after two attempts to treat pain, in 64% after three attempts, and in up to 72% after four attempts. Pain could not be controlled in 28% of the patients. Patients with tumor recurrence had a short median survival time of 3 months, regardless of pain control. Patients with neuropathic pain had a survival time of 16 months or more (median not reached). The authors conclude that the type and cause of the pain in cancer of the head and neck can be determined; this can lead to the administration of proper symptomatic therapy or treatment directed at the underlying cause. In most cases, several successive attempts to treat pain were made before relief was achieved.
authors.affiliation: Department of Neurology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: Vecht
authors.forename: A M
authors.initials: AM
authors.lastname: Hoff
authors.forename: P J
authors.initials: PJ
authors.lastname: Kansen
authors.forename: M F
authors.initials: MF
authors.lastname: de Boer
authors.forename: D A
authors.initials: DA
authors.lastname: Bosch
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D010146:Pain / Q000145:classification / Q000209:etiology*; D059408:Pain Management
chemical_list: D000700:Analgesics