title: Further studies on the hepatoprotective effects of Cochlospermum tinctorium rhizomes.
abstract: The hepatoprotective activity of the rhisome of Cochlospermum tinctorium was investigated using carbon tetrachloride toxicity on mouse and tert-butyl hydroperoxide in vitro induction of lipid peroxidation and hepatocyte lysis. Aqueous, hydro-ethanolic and ethanolic extracts showed significant dose-dependent hepatoprotective actions. The ethanolic extract showed a hepatoprotective activity at lower doses than silymarin. The ethanolic and hydro-ethanolic extracts exhibited remarkable effects against the induction of lipid peroxidation and hepatocyte lysis; the aqueous extract showed comparatively weaker effects. These differences were related to the chemical composition of the extracts. Among the identified constituents of the drug, phenolic and polyphenolic compounds (gallic and ellagic acids, ellagitannins, flavonoids), carotenoids, triterpenes could be related to the biological activity.
authors.affiliation: Laboratoire de Pharmacognosie et de Bromatologie, Université Libre de Bruxelles, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Diallo
authors.forename: R
authors.initials: R
authors.lastname: Vanhaelen-Fastre
authors.forename: M
authors.initials: M
authors.lastname: Vanhaelen
authors.forename: C
authors.initials: C
authors.lastname: Fiegel
authors.forename: M
authors.initials: M
authors.lastname: Joyeux
authors.forename: A
authors.initials: A
authors.lastname: Roland
authors.forename: J
authors.initials: J
authors.lastname: Fleurentin
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010545:Peroxides / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D020122:tert-Butylhydroperoxide
chemical_list: D010545:Peroxides; D010936:Plant Extracts; D008315:Malondialdehyde; D020122:tert-Butylhydroperoxide; D002251:Carbon Tetrachloride; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase