Interferon-gamma may enhance infection of blood-derived macrophages with HIV-1 in the presence of HIV-positive serum.
HIV multiplication in blood-derived macrophages was slightly inhibited by pretreatment of cells with interferon-gamma or by preincubation of virus with serum containing antibodies against HIV. When these pretreatments were combined, the HIV titres observed a short time after infection were enhanced. This effect was blocked by antibodies against Fc receptors but not by antibodies against CD4 receptors. Interferon enhanced the expression of Fc receptors on macrophages. The results indicate that IFN-gamma, in appropriate combinations with HIV-antibody-containing human serum, may enhance the rate of HIV infection of macrophages.
Degré
M
M
Virology section, Wilhelmsens Institute of Bacteriology, University of Oslo, Rikshospitalet, Norway.
Beck
S
S
Rollag
H
H
D000906:Antibodies; D001667:Binding, Competitive; D015704:CD4 Antigens / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006678:HIV / Q000276:immunology / Q000302:isolation & purification*; D015483:HIV Antibodies / Q000276:immunology; D015658:HIV Infections / Q000097:blood*; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects / Q000382:microbiology* / Q000648:ultrastructure; D011961:Receptors, Fc / Q000502:physiology
D000906:Antibodies; D015704:CD4 Antigens; D015483:HIV Antibodies; D011961:Receptors, Fc; D007371:Interferon-gamma