Non-thrombogenicity by novel surface modification methods.
Three novel methods, recently developed by us, for the synthesis of non-thrombogenetic materials were reviewed. The first was the utilization of poly(vinyl sulfonate) as a heparinoid and a newly synthesized polymerizable-thrombin-inhibitor. The chemicals were grafted onto the surfaces of materials. The second was the use of thrombin-substrate-analog peptide. The immobilized peptide was decomposed by blood coagulation factors and inhibited thrombus formation on the surface. The third method was the enhancement of endothelialization by immobilization of bio-signal molecules. The immobilized biosignals remarkably accelerated the growth of endothelial cells.
Ito
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Y
Department of Polymer Chemistry, Kyoto University, Japan.
Imanishi
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Y
D000925:Anticoagulants; D000990:Antithrombin III; D001672:Biocompatible Materials; D005340:Fibrinogen / Q000032:analysis; D006493:Heparin; D006868:Hydrolysis; D008962:Models, Theoretical; D011108:Polymers; D013499:Surface Properties; D013917:Thrombin / Q000032:analysis; D013927:Thrombosis / Q000209:etiology*
D000925:Anticoagulants; D001672:Biocompatible Materials; D011108:Polymers; D000990:Antithrombin III; D005340:Fibrinogen; D006493:Heparin; D013917:Thrombin