The in vivo role of leukocyte function-associated antigen-1 in cytotoxic cell activity against tumors induced by Moloney-murine sarcoma/leukemia retroviral complex.
The in vivo role of LFA-1 molecule in the immune reaction to a murine retrovirus-induced tumor was investigated. Local and systemic treatment with high doses of anti-LFA-1 monoclonal antibody led to tumor progression by blocking CTL interaction with tumor cells without interfering with CTL generation and localization in the tumor mass.
Rosato
A
A
Institute of Oncology, University of Padova, Italy.
Bronte
V
V
Pollis
F
F
Mandruzzato
S
S
Zambon
A
A
Zanovello
P
P
Collavo
D
D
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology*; D051379:Mice; D008979:Moloney murine leukemia virus; D008980:Moloney murine sarcoma virus; D012513:Sarcoma, Experimental / Q000276:immunology*
D000911:Antibodies, Monoclonal; D016169:Lymphocyte Function-Associated Antigen-1