Immunomodulatory effect of interferon-alpha 2b on natural killer cells and T lymphocytes from patients with transitional cell carcinoma of the bladder.
Incubation of peripheral blood mononuclear cells (PBMNC) from patients with transitional cell carcinoma of the bladder, with interferon (IFN-alpha 2b) causes dose-dependent enhancement of natural killer (NK) and cytotoxic activity. Increased lytic activity was also observed against both NK-sensitive and NK-resistant target cells and T lymphocytes from such patients showed altered activity upon incubation with IFN-alpha 2b. Furthermore, intracavitary instillation of IFN-alpha 2b is associated with infiltration of the bladder wall by NK cells and T lymphocytes. Future work will be aimed at investigating the possible prognostic value of these results as related to the therapeutic effect of intracavitary instillation of IFN-alpha 2b.
Alvarez-Mon
M
M
Department of Medicine, Hospital Universitario Principe de Asturias, Universidad de Alcalá de Henares, Spain.
Moltó
L M
LM
Manzano
L
L
Olivier
C
C
Carballido
J A
JA
D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000502:physiology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000628:therapy
D016898:Interferon-alpha