title: Familial varicocele.
abstract: Described are two families in each of which two young males had varicocele. HLA-A, B, C and D5R antigen studies were performed in one family but no genetic factors could be determined. In a review of several large series of patients with varicocele we found no mention of familial occurrence. Although the linkage between adolescent varicocele and spermatogenic dysfunction is still debatable, it is concluded from our experience that it is worthwhile examining other male members of families of affected adolescents or children but that expensive invasive studies are not warranted.
authors.affiliation: Department of Surgery A, Beilinson Medical Center, Petáh Tikva, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Ziv
authors.forename: P M
authors.initials: PM
authors.lastname: Livne
authors.forename: E
authors.initials: E
authors.lastname: Siegenreich
authors.forename: R
authors.initials: R
authors.lastname: Zamir
authors.forename: C
authors.initials: C
authors.lastname: Servadio
mesh_terms: D000293:Adolescent; D006680:HLA Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D014646:Varicocele / Q000235:genetics* / Q000276:immunology
chemical_list: D006680:HLA Antigens; D006684:HLA-DR Antigens