[The importance of removing quinoid radiotoxins from the irradiated organism in the efficacy of hemosorption in the therapy of radiation sickness].
Sorption by SKN-2M coal of various endogenous substances, including quinones (tyrosine oxidation products) and quinoid radiotoxins (QR) isolated from gamma-irradiated plant and animal tissues has been studied. The fact that the precursors of QR-DOPA, tyrosine and QR, isolated from gamma-irradiated plant and animal tissues, are readily absorbed by the sorbent under study supports the major contribution of QR removal from the organism to the therapeutic effect of hemosorption after gamma irradiation of animals with minimal lethal doses.
Kopylov
V A
VA
Revin
A F
AF
Vagabova
M E
ME
Kuzin
A M
AM
D000818:Animals; D002606:Charcoal / Q000627:therapeutic use; D006464:Hemoperfusion / Q000295:instrumentation / Q000379:methods*; D011809:Quinones / Q000032:analysis / Q000302:isolation & purification* / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000628:therapy*; D012639:Seeds / Q000528:radiation effects; D013053:Spectrophotometry
D011809:Quinones; D002606:Charcoal
O znachenii udaleniia khinoidnykh radiotoksinov iz obluchennogo organizma v éffektivnosti gemosorbtsii pri terapii luchevoĭ bolezni.