Plasma phospholipase A2 in children with malignant disorders.
Forty nine children with various malignant disorders showed plasma phospholipase A2 catalytic activity concentrations in the range 0-48 U/l, and in 19 (39%) cases the values significantly exceeded 10 U/l. In 16 healthy children the catalytic concentration never exceeded 10 U/l. Of the 18 children with malignant lymphoma and 16 with acute leukaemia (14 of these with lymphoblastic leukaemia), 44% had plasma phospholipase A2 activities greater than 10 U/l. In 9 patients, an associated infection was either documented or could not be excluded. Of the remaining 40 patients, 33% had enzyme activities above 10 U/l. Although the determination of phospholipase A2 may not be relevant for the diagnosis of a malignancy, it may give an indication of the patient's reaction to the malignant process.
Lukas
R
R
Department of Clinical Chemistry, University of Cluj Medical School, Romania.
Trif
I
I
Cucuianu
M
M
D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000201:enzymology; D008223:Lymphoma / Q000201:enzymology; D008297:Male; D009369:Neoplasms / Q000201:enzymology* / Q000276:immunology; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology
D016207:Cytokines; D010741:Phospholipases A; D054467:Phospholipases A2