Determination of nifedipine in plasma by a rapid capillary gas chromatographic method.
A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single-step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic doses.
Le Guellec
C
C
Laboratoire Hospitalo-Universitaire de Pharmacocinétique et Toxicocinétique, Chu Timone, Marseille, France.
Bun
H
H
Giocanti
M
M
Durand
A
A
D002849:Chromatography, Gas; D006801:Humans; D009543:Nifedipine / Q000097:blood*; D015203:Reproducibility of Results
D009543:Nifedipine