Effect of monensin on liver glutathione, glutathione S-transferase and monooxygenases in rats.
Monensin administered ip to male rats at a dosage of 2.5 mg/kg/d for 3 consecutive days did not change the liver levels of glutathione, but depressed significantly the amount of cytochrome P-450 and the activities of aniline hydroxylase and a cytosolic CDNB-specific glutathione S-transferase. There was a marked decrease in the aminopyrine N-demethylase activity and a significant increase in the pentobarbital sleeping time in rats treated with monensin. In contrast, no change in these parameters was found 2 h after a single ip dose (7.5 mg/kg) of monensin. The results suggest that monensin-induced inhibition of the liver cytosolic glutathione S-transferase and microsomal monooxygenases is non-specific.
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Toxicology Laboratory, School of Veterinary Medicine, Tuskegee University, Alabama 36088.
D000818:Animals; D003580:Cytochromes / Q000032:analysis*; D005978:Glutathione / Q000032:analysis*; D005982:Glutathione Transferase / Q000032:analysis*; D008099:Liver / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D008985:Monensin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D003580:Cytochromes; D008985:Monensin; D005982:Glutathione Transferase; D005978:Glutathione