title: Short-contact treatment at home with Micanol.
abstract: The efficacy of home treatment of psoriasis with a new dithranol formulation, Micanol, was investigated in three studies. They were carried out according to a randomized, within-patient comparison design. In a 4-week pilot study Micanol was compared with placebo (10 patients) and in two 6-week studies Micanol was compared with dithranol 1% in petrolatum (33 patients) and with dithranol 1% in Amitase stick (16 patients). Micanol was found to be effective and well suited for treatment at home in all studies. The vehicle itself did not improve the psoriasis plaques. The rate of clinical improvement was faster for dithranol in petrolatum and Amitase stick than for Micanol. The prevalence and severity of erythema, burning and staining of skin and clothing were far less for Micanol. Approximately half the number of patients preferred dithranol in petrolatum or Amitase stick and the other half preferred Micanol.
authors.affiliation: Department of Dermatology, University Hospital, Trondheim, Norway.
authors.forename: G
authors.initials: G
authors.lastname: Volden
authors.forename: A
authors.initials: A
authors.lastname: Björnberg
authors.forename: E
authors.initials: E
authors.lastname: Tegner
authors.forename: N B
authors.initials: NB
authors.lastname: Pedersen
authors.forename: U B
authors.initials: UB
authors.lastname: Arlés
authors.forename: S
authors.initials: S
authors.lastname: Agren
authors.forename: L
authors.initials: L
authors.lastname: Brolund
mesh_terms: D000287:Administration, Topical; D000875:Anthralin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006701:Home Nursing; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D000875:Anthralin