title: Polycyclic aromatic hydrocarbons (PAHs): a possible cause of lung cancer mortality among nickel/copper smelter and refinery workers.
abstract: A retrospective industrial hygiene investigation was undertaken to explain the cause of a statistically significant excess lung cancer mortality observed in a subset of a large cohort of nickel workers involved in mining, smelting, and refining of nickel and copper in Ontario. The focus of this paper is to demonstrate how an industrial hygiene follow-up assessment of an epidemiologic finding can help to identify a likely cause. Polycyclic aromatic hydrocarbons (PAHs) alone or in association with particulate and gaseous contaminants (e.g., SO2) were likely the causative agents of the excess lung cancer observed among the lead welders, cranemen, and arc furnace workers of the copper refinery.
authors.affiliation: Occupational Health Program, McMaster University, Hamilton, Ontario, Canada.
authors.forename: D K
authors.initials: DK
authors.lastname: Verma
authors.forename: J A
authors.initials: JA
authors.lastname: Julian
authors.forename: R S
authors.initials: RS
authors.lastname: Roberts
authors.forename: D C
authors.initials: DC
authors.lastname: Muir
authors.forename: N
authors.initials: N
authors.lastname: Jadon
authors.forename: D S
authors.initials: DS
authors.lastname: Shaw
mesh_terms: D015331:Cohort Studies; D003300:Copper / Q000009:adverse effects*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D008297:Male; D009532:Nickel / Q000009:adverse effects*; D016273:Occupational Exposure; D016272:Occupational Health; D011083:Polycyclic Compounds / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D014896:Welding
chemical_list: D011083:Polycyclic Compounds; D003300:Copper; D009532:Nickel