The influence of the In(Lu) gene on expression of CDw75 antigens on human red blood cells.
The influence of the In(Lu) gene on human red blood cell (RBC) expression of CDw75 antigens was examined. CDw75 antigens were increased in expression on Lu(a-b-) cells of the dominant inhibitor type in comparison with red cells from donors of other Lutheran (Lu) phenotypes. In contrast, CD44 epitopes detected with F10-44-2, A3D8 and BU52 monoclonal antibodies (mAb) were decreased in expression on Lu(a-b-) red cells. Among normal blood donors of the common phenotype Lu(a-b+) there was a wide range of expression of CDw75 antigens on red cells. The results show that CDw75 is a quantitative polymorphism of human red cells and, among antigens influenced by the In(Lu) gene, is unique in being up-regulated in expression.
Guy
K
K
Human Genetics Unit, Western General Hospital, Edinburgh, U.K.
Green
C
C
D015703:Antigens, CD / Q000032:analysis / Q000235:genetics*; D004912:Erythrocytes / Q000276:immunology*; D005799:Genes, Dominant / Q000276:immunology*; D006801:Humans; D008188:Lutheran Blood-Group System / Q000235:genetics*; D016201:Receptors, Lymphocyte Homing / Q000032:analysis; D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
D015703:Antigens, CD; D008188:Lutheran Blood-Group System; D016201:Receptors, Lymphocyte Homing; D012799:Sialyltransferases; C093493:ST6GAL1 protein, human; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase