Leukemia following cisplatin-based chemotherapy for ovarian carcinoma at Roswell Park.
Three cases of leukemia following cisplatin-based chemotherapy are reported. All three patients received cyclophosphamide, a known leukemogen. In two cases, the leukemia was diagnosed after second line chemotherapy with intraperitoneal cisplatin and cytarabine, one of which is the first report of a chronic granulocytic leukemia as a result of cytotoxic chemotherapy.
Sprance
H E
HE
Department of Gynecologic Oncology Roswell Park Cancer Institute, Buffalo, New York.
Hempling
R E
RE
Piver
M S
MS
D000328:Adult; D002291:Carcinoma, Papillary / Q000188:drug therapy / Q000601:surgery; D002945:Cisplatin / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000139:chemically induced; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced; D015479:Leukemia, Myelomonocytic, Acute / Q000139:chemically induced; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000139:chemically induced*; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D013921:Thrombocytopenia / Q000139:chemically induced
D003561:Cytarabine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin