Adipokinetic hormones: cell and molecular biology.
Adipokinetic hormones AKH I (pGlu-Leu-Asn-Phe-Thr-Pro-Asn-Trp-Gly-Thr-NH2) and AKH II (pGlu-Leu-Asn-Phe-Ser-Trp-Gly-Thr-NH2) are synthesized by neurosecretory cells (NSC) of the corpora cardiaca (CC) in the locust, Schistocerca gregaria. These NSC constitute a homogeneous 'peptide factory' as each cell synthesizes both AKH I and AKH II. This homogeneity makes the CC an excellent system in which to study aspects of neuropeptide biosynthesis. This report summarizes recent findings on AKH inactivation and metabolism, as well as on AKH prohormone processing and biosynthesis.
O'Shea
M
M
Sussex Centre for Neuroscience, School of Biological Sciences, University of Sussex, Falmer, Brighton, United Kingdom.
Rayne
R C
RC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D006110:Grasshoppers / Q000378:metabolism*; D007301:Insect Hormones / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000096:biosynthesis; D012333:RNA, Messenger / Q000737:chemistry
D007301:Insect Hormones; D011498:Protein Precursors; D012333:RNA, Messenger; C014956:adipokinetic hormone (locust)