Teratogenic evaluation of butyl benzyl phthalate in rats by gastric intubation.
Pregnant rats were given butyl benzyl phthalate (BBP) by gastric intubation at a dose of 0, 0.5, 0.75 or 1.0 g/kg on days 7-15 of pregnancy. In the 0.5 g/kg group, food consumption during the administration period was significantly decreased, but no adverse effect on the embryo-fetus was detected. High maternal lethality and complete resorption of implanted embryos in all the surviving dams were observed in the 1.0 g/kg group. Increased embryo-fetal death and decreased fetal weight were found at a dose of 0.75 g/kg which also caused reductions in maternal body weight gain and food consumption. A significantly and markedly increased incidence of fetal malformations was also detected in the 0.75 g/kg group. Cleft palate, fusion of the sternebrae and dilatation of the renal pelvis were mostly observed.
Ema
M
M
National Institute of Hygienic Sciences, Osaka, Japan.
Itami
T
T
Kawasaki
H
H
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption / Q000209:etiology; D005333:Fetus / Q000187:drug effects; D010795:Phthalic Acids / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D010795:Phthalic Acids; C027561:butylbenzyl phthalate