title: Propofol and cholestatic pruritus.
abstract: Hepatic cholestatis is frequently associated with pruritus. This pruritus is often intractable and resistant to conventional treatment. We treated three patients with intractable cholestatic pruritus with subhypnotic doses of propofol, a new intravenous anesthetic induction agent. All patients rapidly became itch- and scratch-free for a period of 60-90 min. No sedation occurred; no other side effects were observed.
authors.affiliation: Department of Anesthesiology and Digestive Surgery, University Hospital of Geneva, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Borgeat
authors.forename: O
authors.initials: O
authors.lastname: Wilder-Smith
authors.forename: G
authors.initials: G
authors.lastname: Mentha
authors.forename: O
authors.initials: O
authors.lastname: Huber
mesh_terms: D000368:Aged; D002779:Cholestasis / Q000150:complications* / Q000209:etiology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications*; D015742:Propofol / Q000627:therapeutic use*; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology
chemical_list: D015742:Propofol