Daily glucose injections facilitate performance of a win-stay water-escape working memory task in mice.
In an experiment that compared 3 versions of a working memory task, male C57BL/6 mice given either 3 (n = 7) or 5 (n = 7) opportunities (test runs) per trial to choose the escape choice section of a maze acquired a win-stay (spatial matching-to-sample) water-escape task. Mice given only 1 test run per trial (n = 6) were unable to perform above chance level. In a 2nd experiment, 14 mice from the 1st experiment were tested for performance on the 3-test-run version of the task. Each mouse was tested for 12 consecutive days with each of 4 doses of glucose (0, 50, 100, & 250 mg/kg ip) given 30 min before testing. The two higher doses increased the percentage of correct test run choices on all 3 daily test runs across the 12 days of testing. Daily glucose injections facilitated the use of trial-dependent information.
Means
L W
LW
Department of Psychology, East Carolina University, Greenville 27858.
Fernandez
T J
TJ
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000502:physiology; D002755:Choice Behavior / Q000502:physiology; D004193:Discrimination Learning / Q000502:physiology; D004924:Escape Reaction / Q000502:physiology*; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009042:Motivation; D009949:Orientation / Q000502:physiology*; D012931:Social Environment
D001786:Blood Glucose; D005950:Glucose Solution, Hypertonic