Stimulation of human airway epithelial cells by platelet activating factor (PAF) and arachidonic acid produces 15-hydroxyeicosatetraenoic acid (15-HETE) capable of contracting bronchial smooth muscle.
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D016718:Arachidonic Acid / Q000494:pharmacology*; D001980:Bronchi / Q000166:cytology / Q000187:drug effects; D016084:Bronchoconstriction; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000378:metabolism*; D010972:Platelet Activating Factor / Q000494:pharmacology*
D006893:Hydroxyeicosatetraenoic Acids; D010972:Platelet Activating Factor; D016718:Arachidonic Acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid