title: Intra-arterial urokinase for treatment of retrograde thrombosis following resection of an arteriovenous malformation. Case report.
abstract: Retrograde thrombosis of feeding arteries is a potentially catastrophic complication occasionally reported following resection of arteriovenous malformations (AVM's). No successful therapy for this condition, which causes postoperative stroke, has previously been reported. A case of retrograde thrombosis of the left middle cerebral artery immediately following resection of a parietal AVM is reported in a patient with a retained intra-arterial catheter from preoperative embolization. The administration of urokinase within 4 hours of surgery resulted in dramatic clinical and angiographic improvement without hemorrhagic complications. While urokinase is considered highly experimental in this setting, this case demonstrates that thrombolytic agents should be viewed as therapeutic options worthy of further investigation.
authors.affiliation: Department of Neurosciences (Division of Neurosurgery), Johns Hopkins Medical Institutions, Baltimore, Maryland.
authors.forename: E P
authors.initials: EP
authors.lastname: Sipos
authors.forename: J R
authors.initials: JR
authors.lastname: Kirsch
authors.forename: H J
authors.initials: HJ
authors.lastname: Nauta
authors.forename: G
authors.initials: G
authors.lastname: Debrun
authors.forename: J A
authors.initials: JA
authors.lastname: Ulatowski
authors.forename: W R
authors.initials: WR
authors.lastname: Bell
mesh_terms: D000328:Adult; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000601:surgery* / Q000628:therapy; D002542:Intracranial Embolism and Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy*; D011859:Radiography; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014568:Urokinase-Type Plasminogen Activator