title: [Disorders of hemostasis after polytrauma. On the extent of intrinsic fibrinolytic activity in the preclinical phase].
abstract: Coagulation disorders are of utmost importance in emergency surgery as well as for secondary organ failure of polytraumatized patients. In order to get hold of the early onset of these disorders, blood samples were harvested from 20 randomly selected patients (Injury Severity Score mean = 36.7 +/- 10.5) on the scene of emergency (mean = 18 [10-29] min after trauma) and at the time of hospital admission (mean = 78 [58-98] min after trauma). In addition to the activation of intravascular coagulation and the consumption of physiological inhibitors, high amounts (10- to 50-fold above normal) of degradation products (FgDP, FbDP, TDP, D-dimers) are present on the scene, already. The influence of hemodilution due to high-volume resuscitation is discussed.
authors.affiliation: Abteilung für Anästhesiologie und Intensivmedizin, Bundeswehrkrankenhaus Ulm.
authors.forename: L
authors.initials: L
authors.lastname: Lampl
authors.forename: K H
authors.initials: KH
authors.lastname: Bock
authors.forename: W
authors.initials: W
authors.lastname: Hartel
authors.forename: M
authors.initials: M
authors.lastname: Helm
authors.forename: M
authors.initials: M
authors.lastname: Tisch
authors.forename: E
authors.initials: E
authors.lastname: Seifried
mesh_terms: D000293:Adolescent; D000328:Adult; D000401:Aircraft; D001779:Blood Coagulation Factors / Q000378:metabolism; D001780:Blood Coagulation Tests; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis / Q000502:physiology*; D005392:First Aid; D006400:Hematocrit; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood*; D010958:Plasminogen / Q000378:metabolism; D010976:Platelet Count
chemical_list: D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D010958:Plasminogen
vernacular_title: Hämostasestörungen nach Polytrauma. Zum Ausmass der körpereigenen fibrinolytischen Aktivität während der präklinischen Phase.