title: [Anal incontinence in patients with Addison's disease: a gluco- and mineralocorticoid independent sphincter malfunction?].
abstract: Anorectal motor function was evaluated in 15 female patients with Addison's disease and androgen deficiency and 15 age-matched healthy volunteers. Medical history revealed symptoms of faecal incontinence in 5 patients. The patients showed decreased maximum retention volumes (p less than 0.01) in the rectal saline infusion test. Lowered anal sphincter resting (p less than 0.01) and squeeze pressure (p less than 0.01) was demonstrated in patients with adrenocortical insufficiency. No differences between patients and controls were found in respect of perception volume, minimal distension volume for sphincter relaxation and rectal compliance by means of intrarectal balloon distension. Electromyography of the external anal sphincter was performed in 8 patients and showed no evidence for a neurogenic defect. Relevant morphological changes of the anorectum could be excluded endoscopically in 13 of the 15 patients. Therefore impaired anorectal muscular function is responsible for faecal incontinence in patients with Addison's disease and androgen deficiency. Further investigations will show, whether these findings are the consequence of lowered androgen production.
authors.affiliation: Abt. für Gastroenterologie und Endokrinologie, J.W. Goethe-Universität, Frankfurt/Main.
authors.forename: T
authors.initials: T
authors.lastname: Wehrmann
authors.forename: P H
authors.initials: PH
authors.lastname: Althoff
authors.forename: B
authors.initials: B
authors.lastname: Lembcke
authors.forename: W F
authors.initials: WF
authors.lastname: Caspary
mesh_terms: D000224:Addison Disease / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000503:physiopathology; D004576:Electromyography; D005242:Fecal Incontinence / Q000503:physiopathology*; D005260:Female; D005938:Glucocorticoids / Q000502:physiology*; D006801:Humans; D008365:Manometry; D008875:Middle Aged; D008901:Mineralocorticoids / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D013739:Testosterone / Q000097:blood*
chemical_list: D005938:Glucocorticoids; D008901:Mineralocorticoids; D013739:Testosterone
vernacular_title: Anale Inkontinenz bei Patienten mit Morbus Addison: Eine gluko- und mineralokortikoid-unabhängige Sphinkterstörung?