Hypovolemia induces Fos-like immunoreactivity in neurons of the rat supraoptic and paraventricular nuclei.
Immunoreactivities to Fos proteins were detected in numerous neurons in the supraoptic, paraventricular and accessory neurosecretory nuclei 1 h following withdrawal of 4-5 cc of blood from the rat femoral arteries. Few or no positive cells were observed in the same nuclei in sham-operated or control animals. It is concluded that hypovolemia induces c-fos expression in hypothalamic neurons known to be associated with blood volume/pressure regulation.
Shen
E
E
Department of Anatomy, Medical College of Ohio, Toledo 43699.
Dun
S L
SL
Ren
C
C
Dun
N J
NJ
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000378:metabolism*; D013495:Supraoptic Nucleus / Q000166:cytology / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos