Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction.
Rejection of transplanted tissue allografts results from T-cell recognition of histocompatibility antigens expressed by cells of the donor graft. This review focuses on the phenotype, specificity, and function of the T cells mediating rejection responses against skin allografts, and on the immune mechanisms by which host T cells are either activated or rendered non-responsive by cellular populations within the graft. We review the cellular basis for rejection responses across limited class-I and class-II major histocompatibility differences, as well as the specificity of the rejection response itself.
Rosenberg
A S
AS
Cytokine Biology Division, Food and Drug Administration, Bethesda, Maryland 20892.
Singer
A
A
D000818:Animals; D006084:Graft Rejection; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D007801:Langerhans Cells / Q000276:immunology; D051379:Mice; D008954:Models, Biological; D016038:Skin Transplantation / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II