Immunoglobulin G, A and M light chain ratio in children.
Values for the kappa/lambda light chain ratio in immunoglobulins G, A and M and the total kappa/lambda ratio, measured by enzyme linked immunosorbent assay, were evaluated in serum samples from different age groups (114 children, aged from 1 month to 15 years, and 20 adults). The IgG kappa/lambda ratio decreased in the first 6 months and subsequently increased slowly during childhood towards the adult value of 2.0. The IgM kappa/lambda ratio increased at a greater rate than IgG kappa/lambda ratio in the first years of life and thereafter rose slightly throughout childhood to reach an adult value of 1.7. A decreasing IgA kappa/lambda ratio was found from 1 month of age onwards to an adult value of 1.1. The pattern of total kappa/lambda ratio was similar to the IgG kappa/lambda ratio with an adult value of 2.0.
Haraldsson
A
A
Department of Paediatrics, University Hospital Nijmegen, The Netherlands.
Weemaes
C M
CM
Kock-Jansen
M J
MJ
Van Eck-Arts
P B
PB
de Boo
T
T
Bakkeren
J A
JA
Stoelinga
G B
GB
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D007223:Infant; D008297:Male; D012016:Reference Values
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M