Quantitative aspects of the fever response elicited by intracerebral injection of endotoxin in the guinea-pig.
Fever developing after intracerebral injections of lipopolysaccharide (LPS) to guinea-pigs were monophasic, with only one peak of inner body temperature slowly developing and longlasting in a dose range 20 to 200 ng of LPS. Latency time was inversely related to the dose of LPS. Indomethacin injected to the third brain ventricle did not abolish fever response.
Spízková
K
K
Department of Physiology and Developmental Biology, Faculty of Science, Charles University, Prague.
Stefl
B
B
D000704:Analysis of Variance; D000818:Animals; D004731:Endotoxins / Q000008:administration & dosage / Q000494:pharmacology*; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D006168:Guinea Pigs; D007213:Indomethacin / Q000494:pharmacology; D007267:Injections; D008070:Lipopolysaccharides / Q000008:administration & dosage; D008297:Male; D011301:Preoptic Area
D004731:Endotoxins; D008070:Lipopolysaccharides; D007213:Indomethacin