Fatal hyperthermia in a quadriplegic man. Possible evidence for a peripheral action of haloperidol in neuroleptic malignant syndrome.
A patient with a cervical cord transection isolating his hypothalamic thermoregulatory centers from peripheral effectors suffered a fatal hyperthermic episode after receiving haloperidol. This suggests that neuroleptic malignant syndrome is caused by a peripheral, not central, effect of haloperidol.
Downey
R J
RJ
Columbia-Presbyterian Medical Center, New York.
Downey
J A
JA
Newhouse
E
E
Weissman
C
C
D000328:Adult; D005334:Fever / Q000139:chemically induced* / Q000473:pathology; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology* / Q000473:pathology; D011782:Quadriplegia / Q000150:complications* / Q000209:etiology / Q000473:pathology; D013119:Spinal Cord Injuries / Q000150:complications / Q000473:pathology; D014948:Wounds, Gunshot / Q000150:complications / Q000473:pathology
D006220:Haloperidol