Immunohistochemical characterization of pigmented villonodular synovitis.
Pigmented villonodular synovitis is made up of a variety of cells, including round or oval mononuclear cells, fibroblasts, synovial cells and multinucleated giant cells. The mononuclear cells were found to stain positively with anti-lysozyme, anti-alpha-1-antitrypsin, anti-alpha-1-antichymotrypsin and anti-fibronectin. Vimentin was detected in fibroblasts and in lining cells of the synovial membrane as well as in cells of acinus-like structures. The multinuclear giant cells contained lysozyme, alpha-1-antitrypsin and alpha-1-antichymotrypsin but no vimentin.
Józsa
L
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Department of Morphology, National Institute of Traumatology, Budapest, Hungary.
D000328:Adult; D004730:Endothelium, Vascular / Q000737:chemistry / Q000473:pathology; D005260:Female; D005347:Fibroblasts / Q000737:chemistry / Q000473:pathology; D005353:Fibronectins / Q000032:analysis; D015726:Giant Cells / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D012189:Retrospective Studies; D013583:Synovial Membrane / Q000737:chemistry / Q000473:pathology*; D013586:Synovitis, Pigmented Villonodular / Q000473:pathology*; D014746:Vimentin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D005353:Fibronectins; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D009113:Muramidase