title: Early and late B-cell development in the mouse.
abstract: A common principle in B-cell development is the stringent selection of cells expressing appropriate antibody V regions as surface receptors. Cells failing to do so appear destined to rapid death. These life-death decisions are mediated by signals whose nature is not yet understood but whose generation involves immunoglobulin receptor complexes on B cells and B-cell progenitors.
authors.affiliation: Institute for Genetics, University of Cologne, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Rajewsky
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016923:Cell Death / Q000276:immunology; D002454:Cell Differentiation; D051379:Mice; D011947:Receptors, Antigen, B-Cell / Q000276:immunology
chemical_list: D011947:Receptors, Antigen, B-Cell