Triazole antifungals. V. Synthesis and antifungal activities of some amides related to 3-acylamino-2-aryl-1-triazolyl-2-butanol.
Amides, 2 and 3 related to the potent antifungal triazole-amide 3-acylamino-2-aryl-1-triazolyl-butanol(1) were synthesized starting from the triazole-alcohol 6. The antifungal activity of 2 and 3 against a mouse systemic Candida albicans infection was found to be less potent than that of 1.
Tanaka
T
T
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd. Tokyo, Japan.
Takeda
N
N
Konosu
T
T
Yasuda
H
H
Oida
S
S
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D002722:Chlorobenzenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000935:Antifungal Agents; D002722:Chlorobenzenes; D014230:Triazoles