Ten-year follow-up of HIV-infected homosexual men with lymphadenopathy syndrome: evidence for continuing risk of developing AIDS.
Seventy-five homosexual men with lymphadenopathy syndrome (LAS), subsequently shown to be seropositive for the human immunodeficiency virus (HIV), were enrolled in a prospective study in Atlanta in 1982 and 1983. Subjects have been followed up at 3- to 6-month intervals with clinical and immunologic evaluations, including analysis of T-cell subsets. As of February 28, 1991, AIDS had developed in 36 (48%) of the 75 men. The AIDS cases continued to occur through the 10th year after onset of LAS; the 10-year cumulative incidence of AIDS was 56.6% (Kaplan-Meier survival analysis). Six-year incidence rates following the first observation of a T-helper cell count greater than or equal to 500/mm3, 400-499/mm3, 300-399/mm3, 200-299/mm3, and less than 200/mm3 were 29, 35, 50, 58, and 88%, respectively. Among individual symptoms and signs, only thrush conferred a poorer prognosis (odds ratio = 5.80; 95% confidence interval, 2.93, 11.39, p less than 0.001, Mantel-Byar analysis). The risk of AIDS persists 10 years after the onset of LAS. The AIDS incidence is related directly to T-helper cell depletion; with the exception of thrush, the presence or absence of symptoms and signs appears to be of lesser prognostic significance.
Kaplan
J E
JE
Division of Viral and Rickettsial Diseases Centers for Disease Control, Atlanta, Georgia 30333.
Spira
T J
TJ
Fishbein
D B
DB
Lynn
H S
HS
D000386:AIDS-Related Complex / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000503:physiopathology*; D000328:Adult; D005500:Follow-Up Studies; D005845:Georgia / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D006716:Homosexuality; D006801:Humans; D015994:Incidence; D008297:Male; D012306:Risk