[Neuroendocrine tumors].
The original classification of neuroendocrine tumours proposed by Pearse was based on a common embryologic origin in the neuroectoderm. This is being replaced by other classifications based on results of modern techniques: secretory granules shown by electron microscopy, neuroendocrine tumour markers (NSE, chromogranin A, NPY ... ) shown by immunocytochemistry and blood measurements. Most endocrine tumours are single and sporadic, but in some patients they are multiple and/or occur as a familial disease such a multiple endocrine neoplasia or other disease, the transmission of which is autosomal dominant. This permits a more reliable classification of tumors, that can be used to determine their prognosis and response to therapy.
Caillou
B
B
Service d'histopathologie A, institut Gustave-Roussy, Villejuif.
Tartour
E
E
Schlumberger
M
M
D014408:Biomarkers, Tumor / Q000032:analysis; D004701:Endocrine Gland Neoplasms / Q000145:classification / Q000473:pathology*; D006801:Humans; D009423:Nervous System Neoplasms / Q000145:classification / Q000473:pathology*; D009490:Neurosecretory Systems
D014408:Biomarkers, Tumor
Les tumeurs neuro-endocrines.