title: Ultraviolet B-irradiated antigen-presenting cells display altered accessory signaling for T-cell activation: relevance to immune responses initiated in skin.
abstract: A principal mechanism by which ultraviolet (UV) B radiation exerts its selective and antigen-specific suppressive influence on immune responses is through its effects on the capacity of antigen-presenting cells (APC) in skin, primarily Langerhans cells (LC), to differentially activate T-cell subsets. Recent evidence has indicated that LC, following UVB radiation, lose the capacity to stimulate proliferation of CD4+ Th1, but not of Th2, clones. Additional work has shown this acquired unresponsiveness of Th1 cells to represent a long-lasting form of clonal anergy that results from a block in their ability to produce IL-2. Although not completely delineated, these defects appear to be the result of preserved delivery of the primary signal transduced by interaction of the MHC/antigen complex on APC with the T-cell receptor complex, in the absence of a viable second signal normally delivered by interaction of a co-stimulatory factor from APC with its appropriate ligand on the T cells. These findings support the notion that the outcome of certain immune responses depends greatly upon conditions that are brought to bear on APC and T cells during the time of antigen presentation.
authors.affiliation: Department of Dermatology, University of Freiburg, Germany.
authors.forename: J C
authors.initials: JC
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Krutmann
authors.forename: C A
authors.initials: CA
authors.lastname: Elmets
authors.forename: P R
authors.initials: PR
authors.lastname: Bergstresser
authors.forename: P D
authors.initials: PD
authors.lastname: Cruz
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000528:radiation effects*; D003877:Dermatitis, Contact / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D012867:Skin / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014466:Ultraviolet Rays