title: [An experimental study of the amides of aromatic carboxylic acids as radiosensitizing agents].
abstract: In experiments with mice a study was made of the radiosensitizing efficacy of 10 aromatic carbonic acid amides, benzene, naphthalene, pyridine and quinoline derivatives. It has been found, for this group of substances, that there is a direct correlation between the ability of the substance to reduce the splenic endocolonies production and the inhibitory activity with regard to poly(ADP-ribose) polymerase of thymocyte nuclei. Within the group of substances under study, new agents are found and described and new relationships are revealed between their chemical structure and biological activity.
authors.forename: V G
authors.initials: VG
authors.lastname: Vladimirov
authors.forename: I I
authors.initials: II
authors.lastname: Krasil'nikov
authors.forename: Iu E
authors.initials: IuE
authors.lastname: Beliaev
authors.forename: I N
authors.initials: IN
authors.lastname: Morozova
authors.forename: O V
authors.initials: OV
authors.lastname: Arapov
authors.forename: O F
authors.initials: OF
authors.lastname: Alferova
mesh_terms: D000577:Amides / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology* / Q000633:toxicity; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays; D008297:Male; D051379:Mice; D011064:Poly Adenosine Diphosphate Ribose / Q000037:antagonists & inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology* / Q000633:toxicity; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011838:Radiation-Sensitizing Agents; D011064:Poly Adenosine Diphosphate Ribose
vernacular_title: Eksperimental'noe izuchenie amidov aromaticheskikh karbonovykh kislot v kachestve radiosensibiliziruiushchikh sredstv.