Cellular and molecular mechanisms in early hematopoietic differentiation.
Recently developed methodology allows virtually complete purification and abundant recovery of hematopoietic progenitors from human adult peripheral blood (PB) (1). We have recently utilized the population of stringently purified progenitors to investigate cellular and molecular mechanisms underlying the early steps of hematopoietic differentiation. Three aspects of these studies are briefly reported here.
Testa
U
U
Department of Hematology-Oncology, Istituto Superiore di Sanità, Rome, Italy.
Valtieri
M
M
Carè
A
A
Pelosi
E
E
Gabbianelli
M
M
Montesoro
E
E
Sposi
N M
NM
Bulgarini
D
D
Camagna
A
A
Isacchi
G
G
D002454:Cell Differentiation; D003114:Colony-Forming Units Assay / Q000379:methods*; D003429:Cross Reactions; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D050981:Erythroid-Specific DNA-Binding Factors; D006098:Granulocytes / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D016184:Receptors, Colony-Stimulating Factor / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D004268:DNA-Binding Proteins; D050981:Erythroid-Specific DNA-Binding Factors; D012333:RNA, Messenger; D016184:Receptors, Colony-Stimulating Factor; D014157:Transcription Factors