Treatment of chronic erosions of junctional epidermolysis bullosa with human epidermal allografts.
We have successfully treated chronic central facial erosions of a patient with junctional epidermolysis bullosa using cultured epidermal allografts. Keratinocytes isolated from a skin biopsy of the patient's biological mother were used to generate the epidermal allografts. Significant re-epithelialization occurred during the course of four grafting procedures. Cultured epidermal allografts appear to be a promising method for treatment of chronic erosions of junctional epidermolysis bullosa.
Hill
J C
JC
Dermatology Service, Brooke Army Medical Center, Fort Sam Houston, San Antonio, TX 78234-6200.
Grimwood
R E
RE
Parsons
D S
DS
D002478:Cells, Cultured; D002648:Child; D004817:Epidermis / Q000637:transplantation*; D004820:Epidermolysis Bullosa / Q000473:pathology / Q000601:surgery*; D005148:Facial Dermatoses / Q000473:pathology / Q000601:surgery*; D006801:Humans; D015603:Keratinocytes; D008297:Male; D012880:Skin Pigmentation; D014184:Transplantation, Homologous