title: Improved insulin sensitivity in hyperinsulinaemic ponies through physical conditioning and controlled feed intake.
abstract: Ten hyperinsulinaemic ponies divided into conditioned (N = 5) and rested (N = 5) groups were evaluated for their insulin and glucose response following oral glucose administration at Weeks 0, 2, 4, and 6. All ponies received a controlled intake of a pelleted ration during the study. In both groups body weight had decreased from baseline by Week 4 and remained low. After 2 weeks of exercise, ponies in the conditioned group had significantly decreased insulin and glucose indices, including peak insulin response, area under the insulin curve from 0 to 210 min (TIS), and the TIS value: area under the glucose curve from 0 to 210 min. By Week 4 of conditioning, although the insulin and glucose indices continued to decrease in the exercised ponies, there was no significant difference between the groups. Over the first 6 weeks of the study all ponies improved their insulin sensitivity accompanied by a loss of body weight. The conditioned ponies were further evaluated during deconditioning at Weeks 8, 10 and 12. The improved insulin sensitivity was maintained during deconditioning.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
authors.forename: J F
authors.initials: JF
authors.lastname: Freestone
authors.forename: R
authors.initials: R
authors.lastname: Beadle
authors.forename: K
authors.initials: K
authors.lastname: Shoemaker
authors.forename: R T
authors.initials: RT
authors.lastname: Bessin
authors.forename: K J
authors.initials: KJ
authors.lastname: Wolfsheimer
authors.forename: C
authors.initials: C
authors.lastname: Church
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D004435:Eating; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D006946:Hyperinsulinism / Q000628:therapy / Q000662:veterinary*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D009752:Nutritional Status; D010805:Physical Conditioning, Animal
chemical_list: D001786:Blood Glucose; D007328:Insulin