Higher sensitivity of LEC strain rat in radiation-induced acute intestinal death.
LEC strain rats (LEC rats), which have been known to develop hereditarily spontaneous fulminant hepatitis 4-5 months after birth, were highly sensitive to whole-body X-irradiation as compared to WKAH strain rats (WKAH rats). Radiation-induced acute intestinal death occurred at doses higher than 6.5 Gy in LEC rats, and at doses higher than 12.8 Gy in WKAH rats, respectively. By the probit analysis of survival data, it was shown that the LD50/7 value of LEC rats was estimated to be 7.03 Gy which was significantly lower than that (12.99 Gy) of WKAH rats. Histopathological examinations of small intestines from LEC rats 2 days after irradiation at the dose of 8.5 Gy showed severe epithelial death together with edema, whereas little or no significant changes were noted in intestinal epithelium of 8.5 Gy-irradiated WKAH rats. These results suggest that the radiosensitivity of LEC rats to ionizing radiation appears to be higher than that of other strains of rats.
Hayashi
M
M
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Endoh
D
D
Kon
Y
Y
Yamashita
T
T
Hashimoto
N
N
Sato
F
F
Kasai
N
N
Namioka
S
S
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004848:Epithelium / Q000528:radiation effects; D005260:Female; D007583:Jejunum / Q000528:radiation effects*; D007928:Lethal Dose 50; D011833:Radiation Injuries, Experimental / Q000401:mortality*; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000401:mortality*