title: Prediction of bone adaptation in the ulnar-osteotomized sheep's forelimb using an anatomical finite element model.
abstract: A method for the prediction of the time-course of bone adaptation based on an alternative hypothesis of strength optimization has been previously investigated and developed by Prendergast and Taylor. This paper extends our work in the study of the effectiveness of this bone adaptation model in predicting similar bone remodelling to that observed in animal experiments. In particular the experimental work which has been modelled is that of Lanyon, Goodship, Pye and McFie. An anatomical finite element model of the sheep's forelimb has been generated for this purpose and is used to estimate stresses in the bone structure for the normal and osteotomized condition. The propensity for remodelling of the altered bone structure is predicted using the proposed remodelling law for the new stress field in the bone structure. The preliminary results indicate an initial bone adaptation pattern similar to that observed experimentally without the necessity to use arbitrarily different constants for the endosteal and periosteal surfaces. We therefore suggest that the remodelling law based on damage and repair gives a better predictive model of bone adaptation than previous models.
authors.affiliation: Bioengineering Research Centre, Trinity College, Dublin, Ireland.
authors.forename: B P
authors.initials: BP
authors.lastname: McNamara
authors.forename: P J
authors.initials: PJ
authors.lastname: Prendergast
authors.forename: D
authors.initials: D
authors.lastname: Taylor
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001696:Biomechanical Phenomena; D016723:Bone Remodeling; D003198:Computer Simulation; D008954:Models, Biological; D010027:Osteotomy; D011884:Radius / Q000502:physiology / Q000601:surgery; D012756:Sheep; D014457:Ulna / Q000502:physiology / Q000601:surgery*