Slowly progressive familial dementia with recurrent strokes and white matter hypodensities on CT scan.
We describe 2 normotensive sisters presenting slowly progressive dementia associated with acute or subacute focal neurological symptoms, unilateral or bilateral motor signs, and dysarthria. Their father, who died in the seventh decade, had a similar clinical picture. Computerized axial tomography (CT) scan of the head showed symmetrical hypodensities in the periventricular white matter and mild to moderate hydrocephalus. In these patients a diagnosis of Binswanger's disease was based on the clinical features supported by white matter changes on CT scan. Our study suggests that genetic factors may play a role in the etiology of Binswanger's disease.
Salvi
F
F
Clinica Neurologica Università di Bologna, Ospedale Bellaria.
Michelucci
R
R
Plasmati
R
R
Parmeggiani
L
L
Zonari
P
P
Mascalchi
M
M
Tassinari
C A
CA
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000000981:diagnostic imaging / Q000523:psychology; D015140:Dementia, Vascular / Q000150:complications / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012008:Recurrence; D013577:Syndrome; D014057:Tomography, X-Ray Computed