The insulin signal and its effects on the pyruvate dehydrogenase complex in circulating lymphocytes of obese children.
1. Studies have shown that in circulating lymphocytes pyruvate dehydrogenase (PDH) is responsive to insulin. 2. To improve existing knowledge on how insulin influences PDH behaviour, situations in which cell responsiveness to insulin is impaired could be of interest. 3. PDH behaviour in circulating lymphocytes from obese children, with high plasma insulin levels and normal glucose tolerance, was examined. 4. Masking and unmasking processes of insulin receptors on the plasma membrane appear to modulate the enzyme response to insulin.
Curto
M
M
Dipartimento di Medicina e Oncologia Sperimentale-Sezione Biochimica, Università di Torino, Italy.
Piccinini
M
M
Cerutti
F
F
Rabbone
I
I
Mostert
M
M
Sacchetti
C
C
Bruno
R
R
Rinaudo
M T
MT
D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D009765:Obesity / Q000201:enzymology*; D011768:Pyruvate Dehydrogenase Complex / Q000097:blood*
D007328:Insulin; D011768:Pyruvate Dehydrogenase Complex