Airway pharmacology of the potassium channel opener, HOE 234, in guinea pigs: in vitro and in vivo studies.
The smooth muscle relaxant effects of the novel potassium channel opener, HOE 234, were investigated in guinea pig airways and compared with those of lemakalim (BRL 38227). Both agents evoked concentration-related reduction in spontaneous tracheal tone or in the tone induced by histamine, prostaglandin E2 or carbachol. HOE 234 was more potent, particularly against carbachol, and was considerably longer acting than lemakalim in a wash-out experiment. On testing for preventive efficacy against histamine-induced bronchoconstriction in anaesthetized animals a dose-related decrease of pulmonary resistance (RL) was observed. HOE 234 given either intravenously (i.v.) or by inhalation was longer acting and 3 and 6 times more potent than lemakalim. Administration of 30 micrograms/kg i.v. HOE 234 during continuous bronchoconstriction maintained by infusion of histamine decreased RL for more than 20 min whereas the effect of 100 micrograms/kg i.v. lemakalin disappeared within 4 min. These results show that HOE 234 is effective against contractile response induced by asthma mediators in guinea pig airways and compares favourably with lemakalim. Moreover it acts on acute existing bronchospasm and therefore has the potential to act against asthma attacks.
Englert
H C
HC
Hoechst AG, Frankfurt/Main, F.R.G.
Wirth
K
K
Gehring
D
D
Fürst
U
U
Albus
U
U
Scholz
W
W
Rosenkranz
B
B
Schölkens
B A
BA
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology; D016085:Bronchoconstrictor Agents / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D002839:Chromans / Q000494:pharmacology*; D019806:Cromakalim; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D015221:Potassium Channels / Q000187:drug effects*; D011758:Pyrroles / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
D001578:Benzopyrans; D016085:Bronchoconstrictor Agents; D001993:Bronchodilator Agents; D002839:Chromans; D015221:Potassium Channels; D011758:Pyrroles; D011759:Pyrrolidines; D019806:Cromakalim; C075012:rilmakalim; D006632:Histamine; D002217:Carbachol; D015232:Dinoprostone