title: The effect of intravenous furosemide on the Doppler waveform in normal kidneys.
abstract: Duplex Doppler sonography is currently being evaluated in the differentiation of obstructive and nonobstructive hydronephrosis. It was thought that this method may be of use in the diagnosis and follow-up of pelviureteric junction obstruction, and that its sensitivity may be increased by the use of intravenous furosemide to raise the intrarenal pressure in obstructive cases. Before embarking on a formal study, a pilot study was initiated to determine the effect of furosemide on the Doppler waveform of the normal kidney. Intravenous furosemide had variable effects on peak systolic and end-diastolic velocities and little significant effect on resistive index but caused a constant and dramatic subjective increase in vascularity. Possible modes of action are discussed.
authors.affiliation: Department of Diagnostic Radiology, University Hospital of Wales, College of Medicine, Cardiff.
authors.forename: S A
authors.initials: SA
authors.lastname: Renowden
authors.forename: D L
authors.initials: DL
authors.lastname: Cochlin
mesh_terms: D000328:Adult; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography
chemical_list: D005665:Furosemide