title: [Intralesional therapy of melanoma metastases with recombinant interferon-beta].
abstract: In ten patients with metastasizing melanomas, discontinuous intratumoral treatment with recombinant interferon beta (rIFN-beta) was administered into 19 cutaneous or palpable subcutaneous metastases. Among the 16 metastases treated with 5 x 10(6) IU per injection, 8 showed partial or complete remission. No recurrence was observed during the 4-9-month follow-up period. There was no regression in 3 metastases treated with 3 x 10(6) IU rINF-beta per injection. No systemic antineoplastic effects were observed in any of the cases. The IFN-beta serum levels were measurably increased following intratumoral application. Local treatment led to a significant increase in (2'-5')oligoadenylate synthetase in the mononuclear blood cells and in the serum. Side-effects of the treatment were moderate; there was a temporary increase in transaminases, a decrease in thrombocytes and influenza-like symptoms. The results show that IFN-beta has a dose-dependent antitumour effect on malignant melanomas.
authors.affiliation: Hautklinik, Universität Tübingen.
authors.forename: G
authors.initials: G
authors.lastname: Fierlbeck
authors.forename: B
authors.initials: B
authors.lastname: d'Hoedt
authors.forename: W
authors.initials: W
authors.lastname: Stroebel
authors.forename: H
authors.initials: H
authors.lastname: Stutte
authors.forename: O
authors.initials: O
authors.lastname: Bogenschütz
authors.forename: G
authors.initials: G
authors.lastname: Rassner
mesh_terms: D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D016899:Interferon-beta / Q000008:administration & dosage*; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D016899:Interferon-beta
vernacular_title: Intraläsionale Therapie von Melanommetastasen mit rekombinantem Interferon-beta.