Unilateral enucleation alters vasoactive intestinal polypeptide-like immunoreactivity in the suprachiasmatic nucleus of the rat.
Adult Sprague-Dawley rats were unilaterally enucleated under deep anesthesia and sacrificed 3-11 months post-operatively. The brains were removed and the suprachiasmatic nuclei were evaluated for vasoactive intestinal polypeptide (VIP)-like immunoreactivity. Our data show that expression of VIP is reduced in the nucleus that is deprived of retinal input.
Laemle
L K
LK
Department of Anatomy, UMDNJ-New Jersey Medical School, Newark 07103.
D000818:Animals; D015353:Eye Enucleation; D007124:Immunoenzyme Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000502:physiology*; D013493:Suprachiasmatic Nucleus / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D014660:Vasoactive Intestinal Peptide