title: Synergism of trimethoprim and ciprofloxacin in vitro against clinical bacterial isolates.
abstract: For the first time, the effects of combinations of trimethoprim and a fluoroquinolone (ciprofloxacin) against gram-positive and gram-negative bacterial isolates were evaluated in vitro. Synergism was found in 31% (fractional inhibitory concentration, FIC) and 33% (fractional bactericidal concentration, FBC) of 121 clinical isolates of various bacterial strains, most often in Escherichia coli, staphylococci, and enterococci. Antagonism occurred in 1% (FIC) and 3% (FBC). The combination of trimethoprim and ciprofloxacin merits further evaluation for potential usefulness as a clinical regimen.
authors.affiliation: Department of Medical Microbiology, Turku University, Finland.
authors.forename: P
authors.initials: P
authors.lastname: Huovinen
authors.forename: J S
authors.initials: JS
authors.lastname: Wolfson
authors.forename: D C
authors.initials: DC
authors.lastname: Hooper
mesh_terms: D002939:Ciprofloxacin / Q000494:pharmacology*; D004357:Drug Synergism; D004755:Enterobacteriaceae / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014295:Trimethoprim / Q000494:pharmacology*
chemical_list: D002939:Ciprofloxacin; D014295:Trimethoprim