Juvenile rheumatoid arthritis and HLA: report of the Park City III workshop.
The workshop held during the Park City Meeting was directed toward developing a consensus about HLA associations in juvenile rheumatoid arthritis (JRA). Most agreement was achieved in pauciarticular JRA where the strongest associations were with the HLA-DRB1 alleles as is also the case in IgM rheumatoid factor positive polyarticular disease. In addition, HLA-DP associations are being identified although roles for linked genes are still possible. The critical nucleotides among HLA genes are not known; however, disease specific mutations have not been shown.
Nepom
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BS
Virginia Mason Research Center, Department of Pediatrics, University of Washington School of Medicine, Seattle.
Glass
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D000483:Alleles; D001171:Arthritis, Juvenile / Q000276:immunology* / Q000503:physiopathology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007596:Joints / Q000503:physiopathology; D012217:Rheumatoid Factor / Q000032:analysis
D006680:HLA Antigens; D007075:Immunoglobulin M; D012217:Rheumatoid Factor