title: Pharmacodynamics of propofol in female patients.
abstract: Although the clinical properties of propofol have been studied extensively, the pharmacodynamics have not yet been described fully. We studied the propofol concentration-effect relationships for loss of eyelash reflex, loss of consciousness, and hemodynamic changes in 18 female patients, ASA physical status 1, aged 20-49 yr. Propofol was given by computer-controlled infusion. The initial target concentration of 0.5-1 microgram/ml was increased every 12 min by 0.5-1 microgram/ml until the patients lost consciousness. Every 3 min, loss of eyelash reflex and loss of consciousness were tested and an arterial blood sample was taken for analysis of the blood propofol concentration. The concentration-response relationships for loss of eyelash reflex and loss of consciousness were defined by fitting a sigmoid Emax function (where Emax = the maximum effect that can be reached; i.e., 100% of the patients showing loss of eyelash reflex or loss of consciousness) to the response/no response data versus the propofol concentration, using nonlinear regression. The effect of propofol on hemodynamic parameters was analyzed by linear regression. The propofol concentrations at which 50% and 90% of the patients showed loss of eyelash reflex were 2.07 and 2.78 micrograms/ml, respectively. The corresponding values for loss of consciousness were 3.40 and 4.34 micrograms/ml. The systolic and diastolic blood pressure decreased with increasing blood propofol concentration. The correlation coefficients for the decrease in systolic and diastolic blood pressure versus the blood propofol concentration were r2 = -0.663 and r2 = -0.243, but heart rate did not change. In conclusion, propofol concentrations inducing loss of eyelash reflex are less than those inducing loss of consciousness.
authors.affiliation: Department of Anesthesiology, Leiden University Hospital, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Vuyk
authors.forename: F H
authors.initials: FH
authors.lastname: Engbers
authors.forename: H J
authors.initials: HJ
authors.lastname: Lemmens
authors.forename: A G
authors.initials: AG
authors.lastname: Burm
authors.forename: A A
authors.initials: AA
authors.lastname: Vletter
authors.forename: M P
authors.initials: MP
authors.lastname: Gladines
authors.forename: J G
authors.initials: JG
authors.lastname: Bovill
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003243:Consciousness / Q000187:drug effects / Q000502:physiology; D005140:Eyelashes / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects / Q000502:physiology; D013514:Surgical Procedures, Operative
chemical_list: D015742:Propofol