Trisomy 8p: unusual origin detected by fluorescence in situ hybridization.
Chromosomal analysis of a neonate with brain and heart abnormalities revealed trisomy for 8p. The mother's karyotype showed 47 chromosomes with one chromosome 8 being represented as two separate chromosomes, an acrocentric 8p and a telocentric 8q. G-banding and silver staining revealed a satellite and nucleolus organizing region (NOR) on the 8p. Centromeric-specific probes to the centromeres of chromosomes 8, 15, 13/21, 22 and the acrocentric chromosomes revealed that only the 8q centromere was of chromosome-8 origin, while the 8p centromere was of chromosome-14 origin.
Moore
C M
CM
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
Barnum
K
K
Kaye
C I
CI
Kagan-Hallett
K S
KS
Liang
J C
JC
D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D015342:DNA Probes / Q000235:genetics; D005260:Female; D005453:Fluorescence; D006801:Humans; D007231:Infant, Newborn; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic / Q000235:genetics; D014314:Trisomy
D015342:DNA Probes