title: Novel thiazolidine-2,4-diones as potent euglycemic agents.
abstract: A new series of thiazolidine-2,4-diones was obtained by replacing the ether function of englitazone with various functional groups, i.e., a ketone, alcohol, or olefin moiety. These compounds lower blood glucose levels in the genetically obese and insulin-resistant ob/ob mouse. Appending an oxazole-based group at the terminus of the chain provided highly potent compounds.
authors.affiliation: Central Research, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: B
authors.initials: B
authors.lastname: Hulin
authors.forename: D A
authors.initials: DA
authors.lastname: Clark
authors.forename: S W
authors.initials: SW
authors.lastname: Goldstein
authors.forename: R E
authors.initials: RE
authors.lastname: McDermott
authors.forename: P J
authors.initials: PJ
authors.lastname: Dambek
authors.forename: W H
authors.initials: WH
authors.lastname: Kappeler
authors.forename: C H
authors.initials: CH
authors.lastname: Lamphere
authors.forename: D M
authors.initials: DM
authors.lastname: Lewis
authors.forename: J P
authors.initials: JP
authors.lastname: Rizzi
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000818:Animals; D001578:Benzopyrans / Q000737:chemistry; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D007659:Ketones / Q000737:chemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045162:Thiazolidinediones
chemical_list: D000438:Alcohols; D001578:Benzopyrans; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007659:Ketones; D013844:Thiazoles; D045162:Thiazolidinediones; C066021:englitazone