title: Burning mouth syndrome: a possible etiologic role for local contact hypersensitivity.
abstract: BACKGROUND
  The pathogenesis of the burning mouth syndrome (BMS) is not yet understood. Apart from psychologic factors, several etiologic "somatic" factors have been reported.
  
  
  OBJECTIVE
  In 22 patients (19 women, 3 men, mean age 56 years) classified with BMS, clinical and laboratory investigations were performed, with particular emphasis on the role of contact hypersensitivity. Twenty of the 22 patients wore a complete or partial denture.
  
  
  METHODS
  Besides clinical and laboratory investigations patch testing was performed with a standard routine series and a standardized denture-dental (acrylate and metal) series.
  
  
  RESULTS
  Folate, iron, pyridoxine deficiency, and Candida infections were found, but correction of the deficiency or treatment of the infection was of no benefit. Contact allergy to allergens used in the production of acrylate-based dentures was observed in six (27%) of the cases (all wore a denture); positive reactions were seen to N,N,-dimethyl-4-toluidine (3 cases), to 4-tolyldiethanolamine (2 cases), to benzoylperoxide (2 cases), and to oligotriacrylate (1 case). In six cases (27%) a possible relevant sensitization was seen to dental metals and in particular to gold chloride (four cases).
  
  
  CONCLUSIONS
  The possible role of local hypersensitivity reactions to denture or dental components as etiologic factors in BMS must be considered.
authors.affiliation: Department of Dermato-Venereology, Academic Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
authors.forename: R O
authors.initials: RO
authors.lastname: Dutrée-Meulenberg
authors.forename: M M
authors.initials: MM
authors.lastname: Kozel
authors.forename: T
authors.initials: T
authors.lastname: van Joost
mesh_terms: D000328:Adult; D000368:Aged; D002054:Burning Mouth Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D003764:Dental Materials / Q000009:adverse effects*; D003778:Dentures; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests
chemical_list: D003764:Dental Materials