title: Encoded combinatorial chemistry.
abstract: The diversity of chemical synthesis and the power of genetics are linked to provide a powerful, versatile method for drug screening. A process of alternating parallel combinatorial synthesis is used to encode individual members of a large library of chemicals with unique nucleotide sequences. After the chemical entity is bound to a target, the genetic tag can be amplified by replication and utilized for enrichment of the bound molecules by serial hybridization to a subset of the library. The nature of the chemical structure bound to the receptor is decoded by sequencing the nucleotide tag.
authors.affiliation: Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037.
authors.forename: S
authors.initials: S
authors.lastname: Brenner
authors.forename: R A
authors.initials: RA
authors.lastname: Lerner
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D016208:Databases, Factual; D015195:Drug Design; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D015183:Restriction Mapping
chemical_list: D010455:Peptides