Effects of administration route on pharmacokinetics of viloxazine in the rabbit.
The absorption of viloxazine chlorhydrate was investigated in ten rabbits. Each animal received the drug (15 mg/kg) by three routes: intravenous, gastric and duodenal. Viloxazine plasma concentrations were low when administered by gastric and duodenal routes compared to those after intravenous injection. Concentrations to peak were 1-2 times higher after duodenal than gastric administration. Times to peak were 23.0 +/- 4.7 min after gastric administration and 9.5 +/- 5.4 min after duodenal administration. A better absorption of viloxazine after administration occurred in the duodenum than in the stomach; these results agree with viloxazine pKa = 8.13. The other pharmacokinetic parameters such as half-life, clearance and volume of distribution where the same irregardless of the administration route.
Thomare
P
P
Department of Pharmacology, Faculty of Medicine, Nantes, France.
Bourin
M
M
Kergueris
M F
MF
Ortega
A
A
Larousse
C
C
D000284:Administration, Oral; D000818:Animals; D006207:Half-Life; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D011817:Rabbits; D014018:Tissue Distribution; D014745:Viloxazine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D014745:Viloxazine