[Effects of stimulation of renal afferent nerve on renal excretion of water, sodium and potassium].
The present study was designed to investigate the effect of stimulation of the renal afferent nerve (RAN) on renal excretory function and its mechanism. In pentobarbital-anesthetized, sino-aortic denervated and vagotomized (SAD+VD) cats, stimulation of the RAN caused a significant rise in arterial pressure. In the denervated kidney urine volume (Vu) and sodium excretion (UNa V) were greatly increased, no changes in potassium excretion (UK V) and glomerular filtration rate (GFR) were observed. In the innervated kidney, UNa V was greatly increased, but Vu, UK V and GFR were not different from those observed during the control period. When arterial pressure was held constant at the control level, stimulation of the RNA reduced the Vu, UK V of both the innervated and denervated kidneys and GFR in the innervated but not in the denervated kidney. Transection of spinal cord at C7 level did not abolish the changes in Vu, UNa V, and UK V in the innervated kidney, but completely eliminated the changes in the excretory function in the denervated kidney. These data suggest that when arterial pressure is controlled, stimulation of the RAN causes a decrease in Vu, UNa V, UK V in SAD+VD cats and that these responses in the innervated kidney can be performed at the spinal level.
Sun
Z
Z
Department of Physiology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
Pan
J Y
JY
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005260:Female; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000294:innervation / Q000502:physiology*; D008297:Male; D009318:Natriuresis; D011188:Potassium / Q000652:urine*
D011188:Potassium