Sequences and factors: a guide to MHC class-II transcription.
The expression of the class-II antigens of the major histocompatibility complex is tissue-specific, developmentally regulated in cells of the B lineage, and inducible by cytokine. Some of the molecular mechanisms that account for this regulation have recently been elucidated. DNA sequences upstream of human and mouse class-II genes that are critical for the transcription of these genes have been identified through transfection studies and transgenic analysis. Furthermore, a number of transcription factors that bind to important promoter motifs have recently been isolated. Examination of the class-II promoter in vivo both in the normal state and in patients with bare lymphocyte syndrome has further increased our understanding of class-II regulation.
Glimcher
L H
LH
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.
Kara
C J
CJ
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005786:Gene Expression Regulation; D005802:Genes, MHC Class II; D006801:Humans; D008969:Molecular Sequence Data; D014158:Transcription, Genetic
D004247:DNA