Encapsulated filtering bleb and subconjunctival 5-fluorouracil.
Filtering bleb encapsulation (BE) involves fibroblast proliferation and collagen synthesis. We analyzed the effect of 5-fluorouracil (5-FU) on the inhibition of BE. Forty-one patients with primary open-angle glaucoma underwent trabeculectomy in one eye as an initial surgery. Twenty-one of these eyes, randomly chosen, were treated postoperatively with four to six 5-FU subconjunctival injections over 10 days to inhibit bleb scarring; the remaining 20 eyes did not receive 5-FU. After 12 to 24 months, the surgical success rate was significantly higher in the treated eyes (P less than .05). However, the incidence of BE was similar: two eyes (9.5% and 10%, respectively) in each group. The difference between the effect of 5-FU in the inhibition of BE and bleb scarring suggests that the characteristics of the two fibroblast populations are heterogeneous.
Ophir
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Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Ticho
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D000368:Aged; D000369:Aged, 80 and over; D005347:Fibroblasts / Q000187:drug effects; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D014130:Trabeculectomy; D016896:Treatment Outcome
D005472:Fluorouracil