title: Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits.
abstract: Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very slight erythema was observed in both skins and this polymer was categorized as a "mild irritant". In the eye irritation test, with a dispersion of the same concentration, it was categorized as "marginal" in unrinsed eyes and "negative" in rinsed eyes.
authors.affiliation: Specialty Chemicals Research Center, Shin-Etsu Chemical Co., Ltd., Niigata, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Obara
authors.forename: H
authors.initials: H
authors.lastname: Muto
authors.forename: H
authors.initials: H
authors.lastname: Kokubo
authors.forename: N
authors.initials: N
authors.lastname: Ichikawa
authors.forename: M
authors.initials: M
authors.lastname: Kawanabe
authors.forename: O
authors.initials: O
authors.lastname: Tanaka
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D005123:Eye / Q000187:drug effects*; D005260:Female; D007509:Irritants; D011817:Rabbits; D012867:Skin / Q000187:drug effects*
chemical_list: D007509:Irritants; D002482:Cellulose; C008079:hydroxypropylcellulose