Abrogation of IL-2 dependence by recombinant murine retrovirus containing v-myb.
Biological consequences of expression of v-myb gene in murine long-term T cell lines (CTLL-2 and HT-2) were studied using murine retroviral vectors. Expression of high levels of v-myb altered responses to interleukin (IL)-2, expression of surface markers, and growth characteristics of these cells. Interestingly, v-myb oncogene brings about growth-factor independence in IL-2-dependent T cell lines with concomitant induction of IL-2 mRNA and downregulation of IL-2 receptor synthesis. These results suggest a role for myb gene products in IL-2 gene expression.
Rose
F V
FV
Wistar Institute, Philadelphia, Pennsylvania 19104.
Reddy
E P
EP
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002472:Cell Transformation, Viral; D015870:Gene Expression; D005822:Genetic Vectors; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000235:genetics / Q000494:pharmacology*; D051379:Mice; D009857:Oncogenes; D015375:Receptors, Interleukin-2 / Q000235:genetics / Q000378:metabolism; D012190:Retroviridae; D013601:T-Lymphocytes / Q000166:cytology* / Q000502:physiology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2