title: [Markedly elevated serum neopterin levels in patients with hemophagocytic histiocytosis].
abstract: The authors measured serum neopterin by HPLC in 3 patients with hemophagocytic histiocytosis (HH) with DIC which occurred during the clinical course of T cell malignant lymphoma (T-ML). Extremely high levels of serum neopterin (754.3 +/- SD 467.3 pmol/ml) were found in the patients, about 200, 13 and 10 times higher than that of normal subjects, non-HH DIC patients and non-HH/DIC T-ML patients. Moreover their serum soluble interleukin-2 receptor levels were markedly elevated. These results indicate that markedly raised serum neopterin would be a sensitive parameter for activation of the mononuclear phagocyte system closely associated with T-cell activation and may serve as a useful diagnostic marker for HH.
authors.affiliation: Division of Transfusion Medicine, Kagoshima University Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Shinmyozu
authors.forename: N
authors.initials: N
authors.lastname: Machigashira
authors.forename: T
authors.initials: T
authors.lastname: Itoyama
authors.forename: I
authors.initials: I
authors.lastname: Maruyama
authors.forename: M
authors.initials: M
authors.lastname: Osame
mesh_terms: D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000097:blood*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000097:blood; D008297:Male; D008875:Middle Aged; D019798:Neopterin; D015375:Receptors, Interleukin-2 / Q000378:metabolism
chemical_list: D015375:Receptors, Interleukin-2; D001708:Biopterins; D019798:Neopterin