Effects of ethanol injection to the preoptic area on sleep and temperature in rats.
Bilateral microinjection of ethanol to the preoptic area of rats causes a dose-dependent hypnotic effect at doses that do not affect brain temperature. Rats were polygraphically recorded for 6 h, and brain temperature was recorded every 10 min for 3 h. Administration of 0.047 mumol ethanol increased total sleep during the 3-6 h interval, while 0.24 and 0.47 mumol ethanol increased deep slow-wave sleep (SWS2) and total sleep during the 3-6- and 0-6-h intervals. The 0.24-mumol ethanol microinjections also increased REM sleep for the 0-6-h interval. No changes in sleep latencies were observed.
Ticho
S R
SR
Department of Pharmacology, College of Medicine University of Illinois, Chicago 60612.
Stojanovic
M
M
Lekovic
G
G
Radulovacki
M
M
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects*; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors
D000431:Ethanol; D012965:Sodium Chloride