Effects of haemolysins of groups A and B streptococci on cardiovascular system.
Anaesthetized New Zealand white rabbits and rats were either injected or infused with streptolysin S and group B streptococcal haemolysins in order to observe the haemodynamic actions of these haemolysins. Results showed that streptolysin S had little or no effect. In contrast, group B streptococcal haemolysin showed significant hypotensive action as manifested in rapid reduction of systolic, mean, diastolic and pulse pressures, and a limited number of deaths due to shock.
Griffiths
B B
BB
Environmental Health Center, Dallas, Texas 75231.
Rhee
H
H
D000818:Animals; D001426:Bacterial Proteins; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002417:Cattle; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006460:Hemolysin Proteins / Q000096:biosynthesis / Q000633:toxicity*; D006801:Humans; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013292:Streptococcus agalactiae / Q000378:metabolism*; D013297:Streptococcus pyogenes / Q000378:metabolism*; D013301:Streptolysins / Q000633:toxicity; D013564:Sympathetic Nervous System / Q000187:drug effects; D013997:Time Factors
D001426:Bacterial Proteins; D006460:Hemolysin Proteins; D013301:Streptolysins; C026050:streptolysin S