Establishment and characterization of Macaca fascicularis lymphoblastoid cell lines.
A panel of cynomolgus macaque lymphoblastoid cell lines (LCL) was established by transforming peripheral blood mononuclear cells (PBMC) with Herpesvirus papio (HVP), and selected lines were examined by flow cytometry. Results indicate that HVP-transformed macaque LCL are phenotypically heterogeneous and resemble human Epstein-Barr virus (EBV)-transformed LCL in the abundant expression of major histocompatibility complex (MHC) class I and class II molecules. At least some lines are of B cell origin.
Manning
C H
CH
Department of Microbiology and Immunology, Bowman Gray School of Medicine, Winston-Salem, NC.
Heise
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ER
D000818:Animals; D002461:Cell Line, Transformed; D002472:Cell Transformation, Viral; D002999:Clone Cells; D005434:Flow Cytometry; D006564:Herpesviridae / Q000502:physiology*; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000382:microbiology*; D008252:Macaca fascicularis