title: Cardiomyopathy in cattle induced by residues of the coccidiostat maduramicin in poultry litter given as a feedstuff.
abstract: An experimental feeding trial was conducted in order to substantiate an hypothesis on the aetiology of a previously unrecorded cardiomyopathic syndrome in beef cattle in Israel. It was believed that residues of the ionophore maduramicin (Cygro; American Cyanamid) in poultry litter fed to cattle, after the maduramicin had been incorporated into broiler feed as a coccidiostat, were the cause of the cardiomyopathy. Three groups of 5 heifers were fed for several weeks (1) poultry litter from a field case, containing 4.8 ppm maduramicin; (2) poultry litter to which maduramicin was added to give a concentration of 12 ppm; (3) poultry litter with no maduramicin (control). Clinical, biochemical, necropsy and histopathological findings showed that maduramicin residues are cardiotoxic, even at the lower level of maduramicin fed, which is commonly encountered in poultry litter in Israel.
authors.affiliation: Kimron Veterinary Institute, Bet Dagan, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Shlosberg
authors.forename: A
authors.initials: A
authors.lastname: Harmelin
authors.forename: S
authors.initials: S
authors.lastname: Perl
authors.forename: G
authors.initials: G
authors.lastname: Pano
authors.forename: M
authors.initials: M
authors.lastname: Davidson
authors.forename: U
authors.initials: U
authors.lastname: Orgad
authors.forename: U
authors.initials: U
authors.lastname: Kali
authors.forename: A
authors.initials: A
authors.lastname: Bor
authors.forename: M
authors.initials: M
authors.lastname: Van Ham
authors.forename: G
authors.initials: G
authors.lastname: Hoida
mesh_terms: D000821:Animal Feed / Q000009:adverse effects / Q000032:analysis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D001773:Blood Cells; D001835:Body Weight; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced* / Q000473:pathology; D003401:Creatine / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004350:Drug Residues / Q000009:adverse effects*; D004573:Electrolytes / Q000097:blood; D005260:Female; D007476:Ionophores / Q000009:adverse effects; D007668:Kidney / Q000473:pathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007783:Lactones / Q000009:adverse effects; D008099:Liver / Q000473:pathology; D009753:Nutritive Value; D011200:Poultry; D014508:Urea / Q000097:blood
chemical_list: D000900:Anti-Bacterial Agents; D004573:Electrolytes; D007476:Ionophores; D007783:Lactones; C018091:maduramicin; D014508:Urea; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D003401:Creatine