title: Spontaneous renal allograft rupture: a disappearing phenomenon in the cyclosporine era?
abstract: Spontaneous renal allograft rupture occurred in six patients in a series of 384 consecutive renal transplants performed between July 1983 and December 1990. All cases occurred in patients treated with Azathioprine and Prednisolone, and none occurred in patients immunosuppressed with Cyclosporine. Acute allograft rejection was the underlying cause of rupture. All patients underwent urgent operation and repair of the ruptured transplant. Four patients had good renal function 74-84 months after repair, while two returned to dialysis 3 and 65 months after repair because of irreversible rejection.
authors.affiliation: Department of Surgery, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: A J
authors.initials: AJ
authors.lastname: Robertson
authors.forename: D M
authors.initials: DM
authors.lastname: Francis
authors.forename: R J
authors.initials: RJ
authors.lastname: Millar
authors.forename: G J
authors.initials: GJ
authors.lastname: Clunie
authors.forename: R G
authors.initials: RG
authors.lastname: Walker
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000494:pharmacology / Q000627:therapeutic use; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007674:Kidney Diseases / Q000209:etiology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology / Q000627:therapeutic use; D012422:Rupture, Spontaneous / Q000209:etiology
chemical_list: D016572:Cyclosporine; D011239:Prednisolone; D001379:Azathioprine