title: Ascending aortic Doppler velocity and the prediction of exercise capacity in post-infarction left ventricular dysfunction.
abstract: A system to improve analysis of the aortic pulsed Doppler velocity signal has been developed and used to study cardiac performance during a 4 min, 25 W incremental stage supine bicycle exercise to exhaustion. Twenty-two male subjects with stable chronic ischaemic heart disease were studied (15 with NYHA class II/III heart failure, and seven age-matched class I subjects). None had evidence of reversible ischaemia. Peak velocity (PV) from the intensity weighted mean velocity profile, early acceleration (eA) and stroke distance (SD) were all significantly lower at rest in class II/III compared to class I. For the change from rest to 50 W, PV did not alter, eAC increased significantly (P less than 0.05) and to a similar extent in both groups (18.6% class II/III vs 16.4% class I) and SD was reduced from 7.8 to 5.9 in class II/III (P less than 0.01) but did not change in class I (12.4 vs 11.8, ns). There was also a greater increase in heart rate (HR) in class II/III subjects (P less than 0.05). The duration of exercise was correlated with resting PV (r = 0.48, P less than 0.025) but was correlated best with the change in blood momentum (PV x Stroke volume x HR) between rest and peak exercise (r = 0.80, P less than 0.001). Thus Doppler velocimetry can give quantitative information on the response to exercise which discriminates between grades of ventricular dysfunction and is predictive of exercise capacity.
authors.affiliation: Cardiac Department, John Radcliffe Hospital, Oxford, U.K.
authors.forename: A J
authors.initials: AJ
authors.lastname: Coats
authors.forename: S
authors.initials: S
authors.lastname: Adamopoulos
authors.forename: J E
authors.initials: JE
authors.lastname: Isea
authors.forename: J
authors.initials: J
authors.lastname: Conway
authors.forename: C
authors.initials: C
authors.lastname: Murphy
authors.forename: P
authors.initials: P
authors.lastname: Sleight
mesh_terms: D000328:Adult; D000368:Aged; D001011:Aorta / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001783:Blood Flow Velocity; D015150:Echocardiography, Doppler; D015444:Exercise / Q000502:physiology; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D016277:Ventricular Function, Left / Q000502:physiology