[Effects of amiridin and tacrine, drugs effective in Alzheimer's disease, on the activity of monoamine oxidase A and B].
In vitro comparative studies of effects of amiridin (9-amino-2, 3, 5, 6, 7, 8-hexahydro-1H-cyclopentane (b) choline monohydrate hydrochloride) and tacrine physostigmine and piracetam on monoamine oxidase A (MAO-A) and B (MAO-B) activity in the rat brain were carried out. Piracetam (1 x 10(-4)-1 x 10(-3) M) dose-dependently increased MAO-A and MAO-B activity. At all concentrations used (1 x 10(-7)-5 x 10(-4) M) physostigmine had no effect on MAO-A and MAO-B activity. Amiridin was found to inhibit MAO-B activity at 5 x 10(-4) M concentration only. Tacrine inhibited MAO-A activity at 5 x 10(-4) M concentration. The therapeutical effects of amiridin and tacrine in treatment of Alzheimer disease were not related to their action on MAO-A and -B activity.
Burov
Iu V
IuV
Baĭmanov
T D
TD
Tat'ianenko
L V
LV
Sokolova
N M
NM
Tereshchenkova
I M
IM
D000544:Alzheimer Disease / Q000188:drug therapy; D000634:Aminoquinolines / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002800:Cholinesterase Inhibitors; D066298:In Vitro Techniques; D008297:Male; D008995:Monoamine Oxidase / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013619:Tacrine / Q000494:pharmacology* / Q000627:therapeutic use
D000634:Aminoquinolines; D002800:Cholinesterase Inhibitors; D011619:Psychotropic Drugs; D013619:Tacrine; C049860:amiridine; D008995:Monoamine Oxidase; D010889:Piracetam
Vliianie amiridina i takrina--preparatov éffektivnykh pri bolezni Al'tsgeĭmera na aktivnost' monoaminoksidazy A i B.