title: Effect of scopolamine on the electrical resistance of the paw pads of mice.
abstract: We examined the electrical resistance of the paw pads of mice under the same conditions as used previously in studies of the passive avoidance response. Administration of scopolamine (0.05-1 mg/kg, SC) 10 or 30 min prior to placement of animals in an experimental box resulted in a profound increase in electrical resistance. In contrast, subcutaneous injection of butylscopolamine (1-20 mg/kg), diazepam (1 or 2 mg/kg), or pentobarbital (10 or 20 mg/kg) did not substantially alter subject resistance. Scopolamine may act on the CNS to induce increased paw skin resistance.
authors.affiliation: Biochemical Research Laboratory, Morinaga Milk Industry Co. Ltd., Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Orikasa
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Kawashima
mesh_terms: D000818:Animals; D002086:Butylscopolammonium Bromide / Q000008:administration & dosage / Q000494:pharmacology; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology; D004594:Electrophysiology; D004597:Electroshock; D005528:Foot; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology; D012601:Scopolamine / Q000008:administration & dosage / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects*
chemical_list: D002086:Butylscopolammonium Bromide; D012601:Scopolamine; D010424:Pentobarbital; D003975:Diazepam