title: Antimicrobial prophylaxis for major head and neck cancer surgery with piperacillin and ornidazole.
abstract: A prospective study in 53 eligible patients, undergoing major head and neck cancer surgery was carried out to assess the combination of an ureido penicillin, piperacillin with a nitro imidazole agent, ornidazole, in order to prevent post-operative general and wound infections. Both antibiotics were administered for five days. Each patient had piperacillin 4 gm every eight hours and ornidazole 1 gm every 24 hours. The overall rate of infections was 13.2 per cent (n = 7), with 3.8 per cent (n = 2) wound infections and 11.3 per cent (n = 6) general infections (one patient presented both complications). There was no wound infection in the total surgery group (n = 12). General infections who only consisted of pneumonias were respectively 12.2 per cent (n = 5) in the group with partial procedures (n = 41) and 8.3 per cent (n = 1) in the total surgery group. This antibioprophylaxis can be recommended in major oncological neck surgery, specially in the case of partial procedures.
authors.affiliation: Département d'Anesthésie, Hôpital Tenon, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Dominici
authors.forename: R
authors.initials: R
authors.lastname: Gondret
authors.forename: V
authors.initials: V
authors.lastname: Broc
authors.forename: S
authors.initials: S
authors.lastname: Dubos
authors.forename: M
authors.initials: M
authors.lastname: Viallard
authors.forename: P
authors.initials: P
authors.lastname: Deligne
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009950:Ornidazole / Q000627:therapeutic use*; D010878:Piperacillin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D011292:Premedication / Q000379:methods*; D011446:Prospective Studies; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D009950:Ornidazole; D010878:Piperacillin