Supercritical fluid extraction of active components in a drug formulation.
Sulfamethoxazole and trimethoprim have been extracted from a drug formulation, Septra Infusion, with pure supercritical carbon dioxide. Both direct extraction of the aqueous-based matrix and indirect extraction of the formulation immobilized onto Celite were studied. Exhaustive analytical extraction was achieved when active components were less than 1.0 mg. A number of co-extractants were found, but each was blind to the HPLC/UV assay.
Mulcahey
L J
LJ
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Taylor
L T
LT
D004338:Drug Combinations; D013420:Sulfamethoxazole / Q000032:analysis*; D014295:Trimethoprim / Q000032:analysis*
D004338:Drug Combinations; D014295:Trimethoprim; D013420:Sulfamethoxazole