Gynecologic complications associated with long-term adjuvant tamoxifen therapy for breast cancer.
The antiestrogen tamoxifen was originally introduced as a therapy for advanced breast cancer. Today, tamoxifen is used to treat selected patients with all stages of breast cancer, and trials are underway to evaluate its effectiveness as a potential breast cancer preventive. When tamoxifen is used as an adjuvant or preventive, extended patient survival times can be expected, and concerns about iatrogenic complications arising from long-term treatment become important. This review discusses currently available laboratory and clinical data regarding the toxicology of tamoxifen and focuses in particular on the gynecologic complications potentially associated with long-term tamoxifen administration.
Wolf
D M
DM
Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison 53792.
Jordan
V C
VC
D001943:Breast Neoplasms / Q000188:drug therapy*; D016889:Endometrial Neoplasms / Q000139:chemically induced; D005260:Female; D005831:Genital Diseases, Female / Q000139:chemically induced*; D006801:Humans; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
D013629:Tamoxifen