Endometrial pattern and thickness associated with pregnancy outcome after assisted reproduction technologies.
The endometrial pattern and thickness was analysed prospectively on the day of administration of human chorionic gonadotrophin (HCG) in 200 in-vitro fertilization (IVF), gamete intra-Fallopian transfer (GIFT) and tubal embryo transfer (TET) cycles. Increasing maturity of the endometrial pattern was positively correlated with oestradiol levels (r = 0.20; P = 0.005), number of mature eggs (r = 0.13; P less than 0.05) and the number of top quality embryos (r = 0.40; P less than 0.001). The endometrial thickness was positively correlated with the number of follicles greater than or equal to 15 mm (r = 0.15; P less than 0.02) and the cycle day on which HCG was administered (r = 0.14; P less than 0.03). It was unaffected by the dose of human menopausal gonadotrophin and was negatively correlated with the use of clomiphene citrate (r = 0.40; P less than 0.001). Fecundity was increased for IVF when the endometrial thickness was greater than or equal to 9 mm (P less than 0.05) and for GIFT and TET when a Type C triple-line endometrial pattern was present (P less than 0.05). Biochemical pregnancies for the combined methods increased from 2.5% of all pregnancies when the endometrial thickness was 9-13 mm, to 27.8% when the thickness was less than 9 mm or greater than 13 mm (P less than 0.01). Biochemical pregnancies occurred in 67% of IVF pregnancies when the endometrial thickness was greater than or equal to 3 mm.(ABSTRACT TRUNCATED AT 250 WORDS)
Dickey
R P
RP
Fertility Institute, New Orleans, LA 70128.
Olar
T T
TT
Curole
D N
DN
Taylor
S N
SN
Rye
P H
PH
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D004717:Endometrium / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D012099:Reproductive Techniques; D014463:Ultrasonography
D006063:Chorionic Gonadotropin; D004958:Estradiol; D007986:Luteinizing Hormone