title: Use of fluoroquinolones for prophylaxis of murine Pneumocystis carinii pneumonia.
abstract: We compared the prophylactic activities of six fluoroquinolones against Pneumocystis carinii pneumonia in immunosuppressed rats. Pefloxacin was the only agent which was as effective as the reference drug trimethoprim-sulfamethoxazole. Clinical trials with pefloxacin in patients at risk for P. carinii pneumonia appear to be justified.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale U. 13., Hôpital Claude Bernard, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Brun-Pascaud
authors.forename: M
authors.initials: M
authors.lastname: Fay
authors.forename: M
authors.initials: M
authors.lastname: Zhong
authors.forename: J
authors.initials: J
authors.lastname: Bauchet
authors.forename: A
authors.initials: A
authors.lastname: Dux-Guyot
authors.forename: J J
authors.initials: JJ
authors.lastname: Pocidalo
mesh_terms: D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D007165:Immunosuppression Therapy; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000382:microbiology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D042462:4-Quinolones; D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination