Prolactin bioassay in schizophrenia before and after neuroleptics.
Fifteen drug-free schizophrenic male inpatients and 14 normal control subjects were studied. The schizophrenic subjects had a significantly lower ratio of bioassay prolactin to radioimmunoassay prolactin before neuroleptic treatment than they did after treatment. The ratio was lower in the drug-free patients as compared with normal controls. These findings suggest that neuroleptic medications may alter the molecular forms of serum prolactin. The results also suggest that drug-free schizophrenic patients may have a different pattern of prolactin variants than normal subjects and that this difference could be secondary to a disordered tuberoinfundibular dopamine system or long-term effects of neuroleptic drugs.
Peabody
C A
CA
Department of Psychiatry, University of Texas Medical School, Houston.
Warner
M D
MD
Griffin
M
M
Boutros
N N
NN
Worsley
I G
IG
Friesen
H G
HG
D000328:Adult; D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D005476:Fluphenazine / Q000008:administration & dosage*; D006220:Haloperidol / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013888:Thiothixene / Q000008:administration & dosage*
D013888:Thiothixene; D011388:Prolactin; D006220:Haloperidol; D005476:Fluphenazine