title: Lens regeneration in juvenile and adult rabbits measured by image analysis.
abstract: Secondary cataract growth commonly occurs after extracapsular cataract extraction. The proliferation of this regrowth occurs at rates related to many factors. In this study, the authors analyzed the amount of lens regeneration after endocapsular lens extraction that leaves the anterior and posterior capsules relatively intact. The analysis was performed in New Zealand albino rabbits with the aid of image analysis measurements in young and adult animals. The effect of low vacuum suction of the anterior capsule on the growth was determined. Lens regeneration was used as a measure of the growth potential of the leftover epithelial cells in the capsule bag. The results showed that lens regeneration was significantly faster in younger rabbits. However, low vacuum suction had no effect on the growth rate. Potential therapeutic agents for preventing secondary cataracts may be better analyzed with image analysis processing of lens regeneration, a precise and rapid measurement technique.
authors.affiliation: University of California, Irvine.
authors.forename: A E
authors.initials: AE
authors.lastname: Gwon
authors.forename: R L
authors.initials: RL
authors.lastname: Jones
authors.forename: L J
authors.initials: LJ
authors.lastname: Gruber
authors.forename: C
authors.initials: C
authors.lastname: Mantras
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002387:Cataract Extraction / Q000379:methods*; D004848:Epithelium / Q000502:physiology; D005260:Female; D007091:Image Processing, Computer-Assisted; D007903:Lens Capsule, Crystalline / Q000601:surgery; D007908:Lens, Crystalline / Q000502:physiology*; D011817:Rabbits; D012038:Regeneration / Q000502:physiology*