title: Liver metabolism of cholesterol taken up from lipoproteins in Wistar rats. An in vivo comparison between rat and human lipoproteins.
abstract: 1. This study compares liver uptake, biliary secretion and blood decay of VLDL, LDL, HDL2 and HDL3 lipoprotein fractions isolated from both rat and human plasma and labelled with [14C]-cholesterol following the i.v. administration to the bile-fistulated rat model. 2. The present results demonstrate that the use of heterologous lipoproteins in bile-fistulated rat can be helpful in administering in a small volume large amounts of free and esterified cholesterol and in evaluating specific aspects of lipoprotein cholesterol metabolism by liver.
authors.affiliation: Istituto Superiore di Sanità, Laboratorio di Metabolismo e Biochimica Patologica, Roma, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Bravo
authors.forename: A
authors.initials: A
authors.lastname: Cantafora
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008074:Lipoproteins; D002784:Cholesterol