Effects of cytokines on the growth of cultured rabbit renal cortical tubular cells.
The effects of various cytokines including interleukin-1 beta, -2, and -6, tumor necrosis factor-alpha, and granulocyte-macrophage colony stimulating factor on the DNA synthesis of cultured rabbit renal cortical tubular cells were investigated. Among these cytokines, it was found that only interleukin-1 beta could stimulate the DNA synthesis of cultured renal tubular cells, while interleukin-6 mildly suppressed the DNA synthesis of such cells. Interleukin-1 beta and -6 are produced by mesangial cells. The above results suggest that these cytokines may regulate the growth of tubular cells via the urinary flow in the nephron.
Kanda
S
S
Department of Urology, Nagasaki University School of Medicine, Japan.
Taide
M
M
Igawa
T
T
Saha
P K
PK
Nishimura
N
N
Nomata
K
K
Kanetake
H
H
Saito
Y
Y
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D007672:Kidney Cortex / Q000166:cytology* / Q000378:metabolism; D007684:Kidney Tubules / Q000166:cytology* / Q000378:metabolism; D011817:Rabbits
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D004247:DNA