title: Diffusion of cefpirome into the cerebrospinal fluid of patients with purulent meningitis.
abstract: We evaluated the diffusion of cefpirome into the cerebrospinal fluid (CSF) of 25 patients with bacterial meningitis or ventriculitis who were receiving conventional antibiotic treatment. A single cefpirome dose of 2 g was infused at day 2-3 after the onset of therapy. Concentrations of cefpirome in serum and CSF obtained at 2, 4, 8 or 12 h after the infusion were determined by high-performance liquid chromatography. The mean (+/- S.E.M.) concentrations of cefpirome in CSF ranged from 2.26 +/- 1.16 to 4.17 +/- 0.83 mg/L. These concentrations were higher than the MBCs for the pathogens usually responsible for bacterial meningitis.
authors.affiliation: Clinique de Réanimation des Maladies Infectieuses, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Wolff
authors.forename: P
authors.initials: P
authors.lastname: Chavanet
authors.forename: A
authors.initials: A
authors.lastname: Kazmierczak
authors.forename: A
authors.initials: A
authors.lastname: Pechinot
authors.forename: C
authors.initials: C
authors.lastname: Dematons
authors.forename: H
authors.initials: H
authors.lastname: Portier
authors.forename: B
authors.initials: B
authors.lastname: Lenfant
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002511:Cephalosporins / Q000134:cerebrospinal fluid* / Q000493:pharmacokinetics; D004058:Diffusion; D005260:Female; D006801:Humans; D008297:Male; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000378:metabolism; D008875:Middle Aged; D000097572:Cefpirome
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097572:Cefpirome