Inhibition of norfloxacin absorption by dairy products.
Seven healthy subjects received, after an overnight fast, a single 200-mg oral dose of norfloxacin with water, whole milk, and unflavored yoghurt. Coadministration of milk or yoghurt reduced the extent of norfloxacin absorption and the mean peak concentration in plasma by approximately 50%. Taking of norfloxacin with these liquid dairy products should be avoided.
Kivistö
K T
KT
Department of Pharmacology, University of Turku, Finland.
Ojala-Karlsson
P
P
Neuvonen
P J
PJ
D000328:Adult; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D003611:Dairy Products; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008892:Milk; D009643:Norfloxacin / Q000493:pharmacokinetics*; D015014:Yogurt
D009643:Norfloxacin