Anti-influenza virus effect of some propolis constituents and their analogues (esters of substituted cinnamic acids).
The antiviral activity of six synthetic substances, esters of substituted cinnamic acids, identical with or analogous to some of the constituents of the Et2O fraction of propolis was studied in vitro. One of them, isopentyl ferulate, inhibited significantly the infectious activity of influenza virus A/Hong Kong (H3N2) in vitro and the production of hemagglutinins in ovo. By the use of diverse experimental patterns, it was found that the maximal inhibition of viral reproduction was observed when test substances were present in the medium during the whole infectious process.
Serkedjieva
J
J
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
Manolova
N
N
Bankova
V
V
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002642:Chick Embryo; D002823:Chorion / Q000187:drug effects; D002934:Cinnamates / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology*; D009975:Orthomyxoviridae / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000382:microbiology / Q000517:prevention & control; D011429:Propolis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D002934:Cinnamates; D003373:Coumaric Acids; C000607202:isopentyl ferulate; D011429:Propolis