title: Riboflavin requirement of Filipino women.
abstract: The level of riboflavin intake that will correct riboflavin deficiency in seven non-pregnant and in twelve pregnant Filipino women was determined in order to reassess the adequacy of the current Recommended Dietary Allowance (RDA) for riboflavin in Filipinos. Increasing levels of riboflavin were given to the subjects who were rated as riboflavin-deficient based on an initial erythrocyte glutathione reductase activation coefficient (EGR-AC) of greater than or equal to 1.3 in screening. The minimum riboflavin requirement, defined as the intake of riboflavin required to achieve an EGR-AC of less than 1.3, was estimated from the regression of EGR-AC on riboflavin intake (mg/1000 kcal). The estimates of minimum riboflavin requirement from the non-pregnant women ranged from 0.16 to 0.42 with a mean of 0.35 +/- 0.09 (SD) mg/1000 kcal. For the pregnant subjects, the estimates of minimum riboflavin requirement ranged from 0.36 to 0.81 with a mean of 0.58 +/- 0.18 (SD) mg/1000 kcal. Adding 30% to the mean, to cover the upper limits of 97.5% of the population, the estimated RDA for non-pregnant women is 0.46/1000 kcal. This value is approximately equal to the 1976 Philippine RDA of 0.5 mg riboflavin/1000 kcal. For pregnant women, adding 30% to the mean minimum requirement of 0.58 mg/1000 kcal, the estimated RDA is 0.75 mg/1000 kcal or 1.75 mg/day computed at the energy allowance of 2350 kcal during pregnancy. This value is 25% higher than the current Philippine RDA of 1.4 mg/day for pregnant women.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Food and Nutrition Research Institute, Department of Science and Technology, Manila, Philippines.
authors.forename: M D
authors.initials: MD
authors.lastname: Kuizon
authors.forename: M G
authors.initials: MG
authors.lastname: Natera
authors.forename: S P
authors.initials: SP
authors.lastname: Alberto
authors.forename: L A
authors.initials: LA
authors.lastname: Perlas
authors.forename: J A
authors.initials: JA
authors.lastname: Desnacido
authors.forename: E M
authors.initials: EM
authors.lastname: Avena
authors.forename: R T
authors.initials: RT
authors.lastname: Tajaon
authors.forename: M P
authors.initials: MP
authors.lastname: Macapinlac
mesh_terms: D000328:Adult; D004734:Energy Metabolism; D004912:Erythrocytes / Q000737:chemistry; D005260:Female; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008403:Mass Screening; D009751:Nutritional Requirements; D010679:Philippines; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control; D012256:Riboflavin / Q000008:administration & dosage / Q000627:therapeutic use*; D012257:Riboflavin Deficiency / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D005980:Glutathione Reductase; D012256:Riboflavin