Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young.
During our search for a marker for non-insulin-dependent diabetes mellitus (NIDDM) in a large multigenerational family with a form of NIDDM termed maturity-onset diabetes of the young (MODY), we learned a great deal that may serve to streamline the search for diabetes-susceptibility genes in other families. We describe here our experience and suggest strategies that may enhance the search for markers for other diabetes susceptibility genes with genetic linkage approaches.
Cox
N J
NJ
Department of Medicine, University of Chicago, Illinois 60637.
Xiang
K S
KS
Fajans
S S
SS
Bell
G I
GI
D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005796:Genes / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree
D005819:Genetic Markers; D004247:DNA