Test-retest stability of cardiovascular and subjective responses to intravenous cocaine in humans.
Sixteen male i.v. cocaine users were measured on their cardiovascular and subjective responses to placebo followed on a separate day by 40 mg i.v. cocaine injections. They were retested within 2 weeks, again receiving placebo and 40 mg i.v. cocaine injections in a random order on separate days. Significant increases in baseline (pre-injection) heart rates during the later sessions were interpreted as possibly reflecting conditioning effects. There were no significant differences in post-injection increases in cardiovascular or subjective responses between the initial and later 40 mg conditions, which might have been indicative of tolerance or sensitization development. Test-retest correlations, indicative of response stability, were moderate to high for any particular timepoint for blood pressure, heart rate, and subjective responses, but pre- vs. post-injection change scores were stable across testings on these measures only under placebo. With the possible exception of some subjective responses, there was little evidence of test-retest stability in responses (change scores) to the 40 mg cocaine injection.
Nagoshi
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Department of Psychology, Arizona State University, Tempe 85287.
Kumor
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KM
Muntaner
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D000328:Adult; D001143:Arousal / Q000187:drug effects*; D003042:Cocaine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D015819:Substance Abuse, Intravenous / Q000503:physiopathology* / Q000534:rehabilitation
D003042:Cocaine