[Triggered activities induced by cesium chloride and terminated by drugs in cat heart in vivo].
Monophasic action potential (MAP) of the left ventricular epicardium in vivo in 58 cats were recorded by using a contact electrode. The results showed that early after depolarization, delayed after depolarization, oscillatory afterpotential, and some kinds of triggered arrhythmias were induced by CsCl (iv 0.5 mmol.kg-1), that these afterdepolarizations and triggered arrhythmias were prevented by sodium valproate, and that ventricular tachycardias induced by CsCl was terminated by lidocaine, moricizine, and sodium valproate.
Li
C L
CL
Department of Biology, Nankai University, Tianjin, China.
Xie
J T
JT
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D002415:Cats; D002586:Cesium; D002712:Chlorides; D005260:Female; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D016293:Moricizine / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D002712:Chlorides; D002586:Cesium; D016293:Moricizine; D014635:Valproic Acid; D008012:Lidocaine; C028019:cesium chloride