Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone.
Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone indicating a possible feedback type of action.
Omkumar
R V
RV
Department of Biochemistry, Indian Institute of Science, Bangalore.
Gaikwad
A S
AS
Ramasarma
T
T
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D005246:Feedback; D006903:Hydroxymethylglutaryl CoA Reductases / Q000302:isolation & purification; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014451:Ubiquinone / Q000494:pharmacology*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases