Sch 42137, a novel antifungal antibiotic from an Actinoplanes sp. Fermentation, isolation, structure and biological properties.
A novel polycyclic xanthone, Sch 42137, related to the albofungin family of compounds was isolated from culture broth. Its structure was determined by detailed spectroscopic studies and comparison of circular dichroic studies to related compounds albofungin and simaomicin. Sch 42137 exhibited MIC values less than 0.125 micrograms/ml against yeasts and dermatophytes. Details are presented herein.
Cooper
R
R
Microbial Products, Schering-Plough Research, Bloomfield, NJ 07003.
Truumees
I
I
Gunnarsson
I
I
Loebenberg
D
D
Horan
A
A
Marquez
J
J
Patel
M
M
Gullo
V
V
Puar
M
M
Das
P
P
D000190:Actinomyces / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002175:Candida / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D002942:Circular Dichroism; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D014249:Trichophyton / Q000187:drug effects*; D014966:Xanthenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D014966:Xanthenes; C074820:SCH 42137; C016969:albofungin