title: Trisomy 4 in acute nonlymphocytic leukemia. Report of two cases and review of the literature.
abstract: Two patients with M2 subtype of acute nonlymphocytic leukemia (ANLL) and trisomy 4 as a primary karyotype change are described. The abnormality was observed in 100% of bone marrow (BM) metaphases in both cases. It appeared alone in one case and was associated with trisomy 13 in 94% of metaphases in the other. These are the second and third cases of ANLL with trisomy 4 documented in Italy. Neither patient appears to have incurred any environmental or therapeutic insult.
authors.affiliation: First Department of Internal Medicine, University of Perugia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Donti
authors.forename: A
authors.initials: A
authors.lastname: Maccari
authors.forename: A
authors.initials: A
authors.lastname: Tabilio
authors.forename: C
authors.initials: C
authors.lastname: Ardisia
authors.forename: N
authors.initials: N
authors.lastname: Campanari
authors.forename: G V
authors.initials: GV
authors.lastname: Donti
mesh_terms: D000368:Aged; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014407:Tumor Cells, Cultured