Long-term stability of lipid emulsions with parenteral nutrition solutions.
The stability of the mixture of peripheral vein parenteral nutrition (PN) solution with 10% lipid emulsions (Intralipid or Lipofundin MCT) was tested during a prolonged period of refrigerated storage. The analysis included gross visual examination of the bottle, pH determination, and examination by electron microscope. The mixtures of fat emulsions with PN solution demonstrated no physical instability or pH alteration. Examination under electron microscope revealed no alterations after 4 wk, but the surface layer of fat globules was disrupted after 10 and 18 wk. This study demonstrates that complete nutritive mixtures can be prepared and stored in refrigeration for at least 4 wk before clinical use.
Tannuri
U
U
Department of Pathology, São Paulo University Medical School, Brazil.
Sesso
A
A
Coelho
M C
MC
Maksoud
J G
JG
D004355:Drug Stability; D005217:Fat Emulsions, Intravenous / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008854:Microscopy, Electron; D010288:Parenteral Nutrition
D005217:Fat Emulsions, Intravenous