[Age-related characteristics of the effects of epithalamin on serotonin metabolism in the pineal gland of rats].
The biosynthesis of serotonin into melatonin was decreased in old (18-20-month) in comparison to young (4-5-month) male Wistar rats. 5-day morning injections to young and old rats with polypeptide pineal preparation (epithalamin) in a dose of 2.5 mg/kg of body weight induced the increase in the night peak of serotonin, N-acetylserotonin and melatonin in young and melatonin alone in old rats and did not influence 5-methoxytryptamine, 5-oxy- and 5-methoxyindoleacetic acids level. These data support suggestion of ultrashort loop between pineal peptides and indoles and that epithalamin increases the metabolism of serotonin into melatonin.
Bondarenko
L A
LA
Anisimov
V N
VN
D000375:Aging; D000818:Animals; D008297:Male; D008550:Melatonin / Q000096:biosynthesis; D010455:Peptides / Q000494:pharmacology*; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D010455:Peptides; D012701:Serotonin; C027437:epithalamin; D008550:Melatonin
Vozrastnye osobennosti vliianiia épitalamina na metabolizm serotonina v shishkovidnoĭ zheleze u krys.