title: Comprehensive medical examination of a group of patients with alleged adverse effects from dental amalgams.
abstract: Mercury from dental amalgams does not seem to cause dose-related intoxications. However, animal studies have shown that high-dose exposure to mercury may support various types of immunologic reactions. Ten patients claiming that their symptoms were caused and aggravated by amalgam therapy were selected for a study of the effects of removal of one amalgam restoration followed by placing of a composite filling. Clinical symptoms and the result of laboratory tests were recorded. Six patients had contact allergies to metals, three of them to mercury ammonium chloride. The comparison of pre- and post-experimental test results showed significant reductions in p-IgE and dU-albumin and significant increases in p-C3d and dU-beta 2-microglobulin. There was no laboratory evidence of a direct toxic effect by mercury on the patients. The observed response by some of the studied factors to the low acute exposure to amalgam may imply that an activation of the immune system occurred.
authors.affiliation: Department of Oral Pathology, University of Umeå, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: Anneroth
authors.forename: T
authors.initials: T
authors.lastname: Ericson
authors.forename: I
authors.initials: I
authors.lastname: Johansson
authors.forename: H
authors.initials: H
authors.lastname: Mörnstad
authors.forename: M
authors.initials: M
authors.lastname: Ryberg
authors.forename: A
authors.initials: A
authors.lastname: Skoglund
authors.forename: B
authors.initials: B
authors.lastname: Stegmayr
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000652:urine; D015933:Complement C3d / Q000032:analysis; D003188:Composite Resins; D003723:Dental Amalgam / Q000009:adverse effects*; D003793:Dental Restoration, Permanent / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008628:Mercury / Q000009:adverse effects* / Q000032:analysis / Q000097:blood / Q000652:urine; D008670:Metals / Q000009:adverse effects; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D010328:Patch Tests; D012463:Saliva / Q000737:chemistry; D014520:Urethane; D001613:beta 2-Microglobulin / Q000652:urine
chemical_list: D003188:Composite Resins; D008670:Metals; D001613:beta 2-Microglobulin; C056413:Occlusin; D007073:Immunoglobulin E; D014520:Urethane; D015933:Complement C3d; D003723:Dental Amalgam; D008628:Mercury