Cellular studies on antigen presentation by class II MHC molecules.
Particularly prominent during the past year was the analysis of the subcellular compartment in which MHC class II molecules are located. Some investigators also analyzed the site where peptides are generated for MHC class II binding. Studies of invariant chain were particularly important in trying to establish the functional significance of this molecule.
Unanue
E R
ER
Washington University School of Medicine, St. Louis, Missouri.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism*; D000941:Antigens / Q000378:metabolism*; D002451:Cell Compartmentation; D004705:Endocytosis; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000502:physiology / Q000648:ultrastructure; D051379:Mice; D015388:Organelles / Q000378:metabolism / Q000648:ultrastructure; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding
D000941:Antigens; D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments