title: Adrenal gland enlargement in major depression. A computed tomographic study.
abstract: To determine whether the well-documented hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients includes adrenal gland hypertrophy, adrenal gland size was evaluated by computed tomography. Assessments consisted of (1) global ratings by two radiologists ignorant of the diagnostic identity of the subjects and (2) calculation of adrenal volume. Of the 38 patients with major depression, 12 were rated as exhibiting adrenal hypertrophy. Adrenal volumes in the depressed patients were significantly increased when compared with those of normal controls. Adrenal gland size was not correlated with dexamethasone suppression test results, patient age, duration of the depressive episode, or depression severity. These results are concordant with the hypothesis that chronic corticotropin hypersecretion in depression results in adrenocortical hypertrophy. Adrenal gland enlargement may be a measure of cumulative lifetime depression.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC.
authors.forename: C B
authors.initials: CB
authors.lastname: Nemeroff
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
authors.forename: D
authors.initials: D
authors.lastname: Reed
authors.forename: R
authors.initials: R
authors.lastname: Leder
authors.forename: C
authors.initials: C
authors.lastname: Beam
authors.forename: N R
authors.initials: NR
authors.lastname: Dunnick
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D003866:Depressive Disorder / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006984:Hypertrophy / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012737:Sex Factors; D014057:Tomography, X-Ray Computed
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone