Safety and efficacy of an attenuated strain of Salmonella choleraesuis for vaccination of swine.
The purpose of this study was to determine the safety and efficacy of a live Salmonella choleraesuis immunizing strain, obtained by repeated ingestion and recovery through porcine neutrophils. The strain was tested in mice and in pigs. The vaccine was safe and effective in controlled experimental trials, using clinical, pathologic, and microbiologic criteria. Vaccinated pigs were able to maintain normal weight gains during the 4-week observation period following challenge inoculation with a high dose of a virulent strain.
Kramer
T T
TT
Department of Microbiology, Immunology, and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames.
Roof
M B
MB
Matheson
R R
RR
D000818:Animals; D001428:Bacterial Vaccines / Q000009:adverse effects; D001831:Body Temperature; D001835:Body Weight; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D051379:Mice; D012475:Salmonella / Q000276:immunology* / Q000472:pathogenicity; D012481:Salmonella Infections, Animal / Q000517:prevention & control*; D013154:Spleen / Q000382:microbiology; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014774:Virulence
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated