title: Patellamide E: a new cyclic peptide from the ascidian Lissoclinum patella.
abstract: A new cyclic peptide, patellamide E [1], was isolated from the ascidian Lissoclinum patella collected at Pulau Salu, Singapore. Its structure was determined by nmr spectroscopy, and its absolute configuration by acid hydrolysis and analysis of the derivatized constituent amino acids by hplc. Patellamide E was mildly cytotoxic against human colon tumor cells in vitro.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112.
authors.forename: L A
authors.initials: LA
authors.lastname: McDonald
authors.forename: C M
authors.initials: CM
authors.lastname: Ireland
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010126:Ozone; D010456:Peptides, Cyclic / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C074721:patellamide E; D010126:Ozone