Transfusion-associated graft-versus-host disease in a presumably immunocompetent patient after transfusion of stored packed red cells.
A 54-year-old woman developed transfusion-associated graft-versus-host disease (TA-GVHD) after the transfusion of stored packed red cells obtained from unrelated donors. The patient was presumed to be immunocompetent. A diagnosis of TA-GVHD was made by clinical features and postmortem pathologic findings. Sex chromatin analysis of the patient's lymphocytes demonstrated chimerism. HLA typing of the blood donors revealed one to be HLA-homozygous for one of the patient's HLA haplotypes (A33-B44-Cblank). This case illustrates the risk in the general patient population of TA-GVHD after routine blood transfusion therapy. Workers should be aware of this possibility and should continue searching for an efficient way to prevent it.
Suzuki
K
K
Department of Hematology, Tokyo Metropolitan Komagome Hospital, Japan.
Akiyama
H
H
Takamoto
S
S
Maruyama
Y
Y
Sakamaki
H
H
Akagi
K
K
Maeda
Y
Y
Takenaka
M
M
Onozawa
Y
Y
D016913:Blood Component Transfusion / Q000009:adverse effects*; D001782:Blood Donors; D002843:Chromatin / Q000302:isolation & purification; D005260:Female; D006086:Graft vs Host Disease / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics; D006239:Haplotypes; D006400:Hematocrit; D006801:Humans; D007121:Immunocompetence; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D002843:Chromatin; D006680:HLA Antigens