title: Aberrations of chromosome 19. Do they characterize a subtype of benign thyroid adenomas?
abstract: We describe the cytogenetic findings in two benign thyroid hyperplasias with aberrations of chromosome 19. In the first patient, two of four nodules showed identical translocations involving chromosome 19 and 22: 46,XX,der(19)t(19;?)(q13;?),der(22)t(22;?)(q12;?), the remaining nodules had an apparently normal karyotype. Two nodules from a second patient were karyotyped. One showed a karyotype 46,XX,t(1;19)(p35-36.1;q13) and the other had a normal karyotype. From these results as well as those reported previously, we can conclude that structural changes of chromosome 19 characterize a subgroup of thyroid adenomas, thyroid hyperplasias, or both.
authors.affiliation: Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Belge
authors.forename: B
authors.initials: B
authors.lastname: Thode
authors.forename: J
authors.initials: J
authors.lastname: Bullerdiek
authors.forename: S
authors.initials: S
authors.lastname: Bartnitzke
mesh_terms: D000236:Adenoma / Q000235:genetics*; D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D013964:Thyroid Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic