Burst activity and synaptic mechanisms in a hypothalamic network grown in culture.
In a cultured network of rat embryonic hypothalamic cells, synaptic interaction is through GABAA-receptors, that mediate inhibition by an increase in Cl- conductance, and AMPA-receptors, that mediate excitation by an increase in monovalent cationic conductance. Changes in the balance of inhibition and excitation towards a predominance of excitation lead to phasic synchronous activity of the cells. Synaptic interaction through these receptors is thus capable of modulating neurosecretion rapidly.
Misgeld
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U
I. Physiologisches Institut der Universität Heidelberg, FRG.
Swandulla
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D
D000200:Action Potentials; D000818:Animals; D002478:Cells, Cultured; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology*