Delayed transplantation of foetal cerebral tissue into injured spinal cord of adult rats.
Delayed transplantation of foetal cerebral tissue into injured spinal cord of adult rats was performed for the purpose of evaluating the usefulness of the procedure for reconstructing the spinal cord and providing motor recovery. Transplanted tissue showed a survival rate greater than 80% and integration with the host tissue. Nerve fibers of the host surrounded the transplanted tissue, penetrating it. Foetal cerebral neurons matured into recipient spinal cord, but they were not organized in layers. The experience obtained suggests that delayed transplantation of foetal cerebral tissue into contused spinal cord is useful in morphological spinal cord reconstruction. Nevertheless, at least during the first two months after transplantation, clinical assessment of motor recovery showed no differences between transplanted and nontransplanted rats.
Vaquero
J
J
Department of Neurosurgery, Autonomous University, Madrid, Spain.
Arias
A
A
Oya
S
S
Coca
S
S
Zurita
M
M
D000818:Animals; D016380:Brain Tissue Transplantation / Q000473:pathology / Q000502:physiology*; D002540:Cerebral Cortex / Q000196:embryology / Q000473:pathology / Q000637:transplantation*; D005260:Female; D016332:Fetal Tissue Transplantation / Q000473:pathology / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009048:Motor Skills / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D010264:Paraplegia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D051381:Rats; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*