Effects of 5-HT3 antagonists on fixed-interval behavior in rats.
The effects of 5-hydroxytryptamine3 (5-HT3) antagonists were studied in rats responding under a fixed-interval (FI) schedule of food presentation. BRL 43694, GR 38032F, ICS-205,930 and zacopride had no effect on FI responding up to 10.0 mg/kg IP. Response rate decreases were observed only at high doses (30.0 or 56.0 mg/kg); rate increases were not observed. In comparison, caffeine (1.0-10.0 mg/kg) and cocaine (3.0-18.0 mg/kg) increased and lorazepam (0.3 mg/kg) decreased FI responding. The effects of caffeine, cocaine, and lorazepam were unchanged when coadministered with the 5-HT3 antagonists. The results show that 5-HT3 antagonists, when given alone or with other CNS-active drugs, have little effect on FI responding of rats.
Wettstein
J G
JG
Department of CNS Pharmacology, Institut de Recherche Jouveinal, Fresnes, France.
Junien
J L
JL
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002110:Caffeine / Q000494:pharmacology; D003042:Cocaine / Q000494:pharmacology; D004347:Drug Interactions; D008140:Lorazepam / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*
D012702:Serotonin Antagonists; D002110:Caffeine; D003042:Cocaine; D008140:Lorazepam