title: Helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion.
abstract: The effect of Helicobacter pylori lipopolysaccharide on guinea pig gastric mucosal pepsinogen secretion has been examined using an Ussing chamber technique. Luminal addition of H. pylori lipopolysaccharide resulted in a fifty-fold stimulation of pepsinogen secretion compared to a twelve-fold increase with E. coli lipopolysaccharide. Electron microscopy showed marked degranulation of zymogen granules but no evidence of chief cell disruption.
authors.affiliation: Gastrointestinal Clinic, Department of Medicine, University of Cape Town, South Africa.
authors.forename: G O
authors.initials: GO
authors.lastname: Young
authors.forename: N
authors.initials: N
authors.lastname: Stemmet
authors.forename: A
authors.initials: A
authors.lastname: Lastovica
authors.forename: E L
authors.initials: EL
authors.lastname: van der Merwe
authors.forename: J A
authors.initials: JA
authors.lastname: Louw
authors.forename: I M
authors.initials: IM
authors.lastname: Modlin
authors.forename: I N
authors.initials: IN
authors.lastname: Marks
mesh_terms: D000818:Animals; D004926:Escherichia coli; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D016480:Helicobacter pylori; D066298:In Vitro Techniques; D008070:Lipopolysaccharides; D008564:Membrane Potentials / Q000502:physiology; D008853:Microscopy; D010435:Pepsinogens / Q000378:metabolism*; D013268:Stimulation, Chemical
chemical_list: D008070:Lipopolysaccharides; D010435:Pepsinogens