title: Elevated serum manganese superoxide dismutase in acute leukemias.
abstract: We measured the serum levels of manganese-superoxide dismutase (Mn-SOD) in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). Serum Mn-SOD level for normal subjects was 94.1 +/- 23.5 ng/ml (mean +/- S.D.), the levels for AML and ALL patients were 159.6 +/- 77.1 ng/ml and 154.4 +/- 77.0 ng/ml, respectively. The serum Mn-SOD levels were unrelated to individual intracellular Mn-SOD levels, but correlated well with serum lactate dehydrogenase values. Regression of the leukemia was accompanied by decrease in the serum level of Mn-SOD. Serum Mn-SOD may thus serve as a measure of the activity of the disease.
authors.affiliation: Department of Biochemistry, Osaka University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishiura
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: H
authors.initials: H
authors.lastname: Nakao
authors.forename: N
authors.initials: N
authors.lastname: Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kanayama
authors.forename: T
authors.initials: T
authors.lastname: Yonezawa
authors.forename: S
authors.initials: S
authors.lastname: Iizuka
authors.forename: N
authors.initials: N
authors.lastname: Taniguchi
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology*; D009000:Monocytes / Q000201:enzymology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000097:blood*
chemical_list: D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase