Neurovascular immunology: a 25-year odyssey.
Small vasoactive neurotransmitter molecules with a long evolutionary history of involvement in biological defense and inflammation play important roles in the up-regulation and down-regulation of the immune response and with similar effects on neuronal and lymphocyte transmembrane signaling molecules and mechanisms. The longest acting of these stimulatory molecules on lymphocyte traffic, substance P and bradykinin, also are transmitters of impulses relating to heat and pain. Heat and pain have been primordial stimuli to learning and memory--immunological as well as CNS.
Moore
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Department of Surgery, UCLA School of Medicine, Torrance 90590.
D000818:Animals; D000845:Annelida / Q000276:immunology; D001920:Bradykinin / Q000502:physiology; D015232:Dinoprostone / Q000378:metabolism; D016027:Heart Transplantation / Q000276:immunology; D006632:Histamine / Q000652:urine; D006640:Histidine Decarboxylase / Q000378:metabolism; D006358:Hot Temperature; D007022:Hypotension / Q000503:physiopathology; D016030:Kidney Transplantation / Q000276:immunology; D008214:Lymphocytes / Q000502:physiology; D015213:Neuroimmunomodulation; D051381:Rats; D012513:Sarcoma, Experimental / Q000378:metabolism; D016038:Skin Transplantation / Q000276:immunology
D006632:Histamine; D006640:Histidine Decarboxylase; D015232:Dinoprostone; D001920:Bradykinin