title: Pulmonary vascular permeability in interstitial lung disease. A positron emission tomographic study.
abstract: We evaluated pulmonary vascular permeability with positron emission tomography (PET) in 16 patients with interstitial lung disease (ILD) by measuring the pulmonary transcapillary escape rate (PTCER) for transferrin labeled with gallium-68. In patients with active ILD, defined by lung biopsy or clinical criteria, mean PTCER was significantly greater than in normal subjects (118 +/- 46 versus 21 +/- 11 x 10(-4) min-1, respectively, p less than 0.05). Mean PTCER in patients with inactive ILD, in contrast, was not different from that in normal subjects (32 +/- 10 x 10(-4) min-1, p = NS). Thus, these data suggest that PET measurements of PTCER might serve as an index of disease activity in patients with ILD.
authors.affiliation: Washington University School of Medicine, Respiratory and Critical Care Division, St. Louis, Missouri 63110.
authors.forename: J D
authors.initials: JD
authors.lastname: Kaplan
authors.forename: E P
authors.initials: EP
authors.lastname: Trulock
authors.forename: D J
authors.initials: DJ
authors.lastname: Anderson
authors.forename: D P
authors.initials: DP
authors.lastname: Schuster
mesh_terms: D000328:Adult; D002199:Capillary Permeability / Q000502:physiology*; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology; D008297:Male; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014055:Tomography, Emission-Computed; D014168:Transferrin
chemical_list: D005710:Gallium Radioisotopes; D014168:Transferrin