Successful renal transplantation in a patient with systemic sarcoidosis and renal failure due to focal glomerulosclerosis.
In 1987, a patient presented with pulmonary sarcoidosis and progressive renal failure. Percutaneous renal biopsy showed focal glomerular sclerosis (FGS). Over the subsequent 4-year period, her renal failure progressed to require hemodialysis. During this time, her pulmonary sarcoidosis was treated with daily corticosteroid therapy and she remained in clinical remission. The patient received a one-haplotype-identical living-related renal transplant from her mother. The patient is now 25 months posttransplant with a serum creatinine of 106 mumol/L (1.2 mg/dL). Her sarcoidosis continues to be in clinical remission. In this report, we review the rare association of a primary glomerular lesion causing renal failure in patients with sarcoidosis. In addition, we detail the first successful renal transplant in such a patient.
Hakaim
A G
AG
Section of Surgery, Boston Veterans Administration Medical Center, MA.
Stilmant
M M
MM
Kauffman
J
J
Schmitt
G
G
Joshi
P
P
Carpinito
G
G
Cho
S I
SI
D000328:Adult; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications / Q000601:surgery*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D008171:Lung Diseases / Q000150:complications* / Q000601:surgery; D012507:Sarcoidosis / Q000150:complications* / Q000601:surgery