Ethanol tolerance developed during intoxicated operant performance in rats prevents subsequent ethanol-induced conditioned taste aversion.
Four groups of Sprague-Dawley rats (n = 10 per group) were trained in a two-phase conditioning experiment. All rats were initially trained in an FR30 operant task (phase 1), and subsequently trained in a conditioned taste aversion (CTA) task. The groups of rats differed in their ETOH exposure. All rats received 2-week chronic exposure in phase 1. Two groups received chronic presession ETOH and, therefore, the opportunity for intoxicated practice; another group, yoked to this latter group, received postsession ETOH; the final group received presession saline injections. The presession ETOH groups were conditioned in the CTA task with either ETOH or saline; both increased their intakes of the conditioned tastant. The presession saline and the postsession ETOH groups received ETOH CTA; both developed a robust CTA. Thus, prior history of intoxicated practice under the operant task prevented the development of ETOH-induced CTA. We argue that ETOH exposure may be a necessary but not sufficient condition for tolerance to develop to the aversive attributes of ETOH.
Gauvin
D V
DV
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190-3000.
Holloway
F A
FA
D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003213:Conditioning, Psychological; D004326:Drinking / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D007858:Learning; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin / Q000008:administration & dosage; D013649:Taste
D000431:Ethanol; D012439:Saccharin