Development of a polymorphic strain of Plasmodium vivax in monkeys.
A strain of Plasmodium vivax from Thailand with a polymorphic repeat unit of the circumsporozoite protein was established in Saimiri sciureus boliviensis and 3 species of Aotus monkeys. All 11 attempts to transmit infection via sporozoite inoculation, 4 times to splenectomized S. sciureus boliviensis, 2 times to splenectomized Aotus nancymai, and 5 times to intact Saimiri monkeys, were successful. Anopheles freeborni, Anopheles stephensi, Anopheles dirus, and Anopheles gambiae mosquitoes were infected by feeding on parasitemic blood from a chimpanzee and an Aotus azarae boliviensis monkey. Our results indicate that this strain may be useful in antisporozoite vaccine trials.
Collins
W E
WE
Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Sattabongkot
J
J
Wirtz
R A
RA
Skinner
J C
JC
Broderson
J R
JR
Millet
P G
PG
Morris
C L
CL
Richardson
B B
BB
Sullivan
J
J
Filipski
V K
VK
D000595:Amino Acid Sequence; D000818:Animals; D000852:Anopheles; D000953:Antigens, Protozoan / Q000737:chemistry*; D001029:Aotus trivirgatus; D004195:Disease Models, Animal; D016780:Malaria, Vivax / Q000097:blood / Q000276:immunology / Q000469:parasitology*; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D010966:Plasmodium vivax / Q000737:chemistry / Q000276:immunology*; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D012453:Saimiri; D013156:Splenectomy
D000953:Antigens, Protozoan; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; C041595:circumsporozoite protein, Protozoan