Alarm substance induces convulsions in imipramine-treated rats.
Male rats were injected with imipramine (0-30 mg/kg) and subsequently tested in the forced-swim test in either fresh water or water soiled by other rats, which presumably contains an alarm substance. Imipramine did not affect the behavior of rats in fresh water. More than half the animals given the combination of imipramine (30 mg/kg) and stress from alarm substance had clonic convulsions. Adrenalectomy did not affect this relationship. This is the first study demonstrating the potential of an alarm substance for inducing convulsions.
Abel
E L
EL
Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201.
Bilitzke
P J
PJ
Cotton
D B
DB
D000311:Adrenal Glands / Q000502:physiology; D000315:Adrenalectomy; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D010675:Pheromones / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology*; D013312:Stress, Physiological / Q000503:physiopathology*
D010675:Pheromones; D007099:Imipramine