Neostigmine-induced characteristics of spontaneous activities and evoked muscle potentials in rat gastrocnemius and soleus muscles.
Using concentric electrodes, spontaneous activities and evoked muscle potentials were recorded from medial gastrocnemius (MG) and soleus (SOL) muscles of Wistar rats about 60 days old. When neostigmine methylsulfate was injected, spontaneous activity such as motor unit discharges occurred in a burst in the MG muscles, in contrast to few activity before the injection of this drug. In the SOL muscles, only single spikes were sometimes observed after it. In coincidence with burst discharges, some oscillations were definitely observed following the main component of MG potentials evoked by single stimuli to a sciatic nerve, whereas only slight deflections could be detected in SOL potentials. Thus, different modification of spontaneous activities and evoked muscle potentials were induced in MG and SOL muscles by the injection of neostigmine methylsulfate.
Uramoto
I
I
Department of Physiology, Institute for Developmental Research, Aichi Prefectural Colony, Japan.
Watanabe
K
K
Totsuka
T
T
D000818:Animals; D004576:Electromyography; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009388:Neostigmine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009388:Neostigmine