title: Effects of cytokines on the growth of cultured rabbit renal cortical tubular cells.
abstract: The effects of various cytokines including interleukin-1 beta, -2, and -6, tumor necrosis factor-alpha, and granulocyte-macrophage colony stimulating factor on the DNA synthesis of cultured rabbit renal cortical tubular cells were investigated. Among these cytokines, it was found that only interleukin-1 beta could stimulate the DNA synthesis of cultured renal tubular cells, while interleukin-6 mildly suppressed the DNA synthesis of such cells. Interleukin-1 beta and -6 are produced by mesangial cells. The above results suggest that these cytokines may regulate the growth of tubular cells via the urinary flow in the nephron.
authors.affiliation: Department of Urology, Nagasaki University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kanda
authors.forename: M
authors.initials: M
authors.lastname: Taide
authors.forename: T
authors.initials: T
authors.lastname: Igawa
authors.forename: P K
authors.initials: PK
authors.lastname: Saha
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: K
authors.initials: K
authors.lastname: Nomata
authors.forename: H
authors.initials: H
authors.lastname: Kanetake
authors.forename: Y
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D007672:Kidney Cortex / Q000166:cytology* / Q000378:metabolism; D007684:Kidney Tubules / Q000166:cytology* / Q000378:metabolism; D011817:Rabbits
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D004247:DNA