Regional cerebral blood flow after long-term exposure to carbon disulfide.
Sixteen former rayon viscose workers were investigated four years after the exposure to carbon disulfide was discontinued. Median age was 58 years (range 43-65 years), median exposure time was 17 years (range 10-35 years). Encephalopathy was diagnosed in altogether 14 workers. To further explore pathophysiological mechanisms, cerebrovascular investigations were employed. Doppler ultrasound examination of the precerebral vessels in 15 workers showed a slight stenosis of the left internal carotid artery in one. Regional cerebral blood flow investigation (rCBF) with single photon emission computerized tomography (SPECT) with Xenon-133 gas was performed in 14. There was no significant difference from a control group. Regional side-to-side asymmetries beyond reference limits were demonstrated in eight workers. The abnormalities were modest, but may indicate a tendency toward focal blood flow disturbances in workers with long-term exposure to carbon disulfide.
Aaserud
O
O
Department of Neurology, Rikshospitalet, Oslo, Norway.
Russell
D
D
Nyberg-Hansen
R
R
Rootwelt
K
K
Jörgensen
E B
EB
Nakstad
P
P
Hommeren
O J
OJ
Tvedt
B
B
Gjerstad
L
L
D000328:Adult; D001921:Brain / Q000098:blood supply*; D001925:Brain Damage, Chronic / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002246:Carbon Disulfide / Q000506:poisoning*; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004453:Echoencephalography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D016273:Occupational Exposure; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon
D002246:Carbon Disulfide