Vaginal disinfection with povidon iodine and the outcome of in-vitro fertilization.
In a prospective randomized study, the influence was assessed of vaginal disinfection with a 1% solution of povidon iodine (Betadine), before performing a transvaginal ultrasound-guided oocyte retrieval, on fertilization, cleavage rate and pregnancy rate. The outcome of 334 oocyte retrievals was studied. In 160 cases, Betadine was used and in the remaining 174 cases, normal saline was used. No differences in the fertilization and cleavage rates were found (fertilization 45.5% versus 47.8%, cleavage 49.8% versus 52.1% in the Betadine and normal saline groups respectively). However the pregnancy rate was significantly higher in the normal saline group (17.2% versus 30.3% clinical pregnancies per embryo transfer). No increase in infection risk occurred in the saline group.
van Os
H C
HC
Department of IVF, Diaconessenhuis, Voorburg, The Netherlands.
Roozenburg
B J
BJ
Janssen-Caspers
H A
HA
Leerentveld
R A
RA
Scholtes
M C
MC
Zeilmaker
G H
GH
Alberda
A T
AT
D004203:Disinfection; D004341:Drug Evaluation; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D009865:Oocytes / Q000187:drug effects*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012965:Sodium Chloride / Q000494:pharmacology; D014621:Vagina / Q000187:drug effects* / Q000382:microbiology
D012965:Sodium Chloride; D011206:Povidone-Iodine