Closing in on a breast cancer gene on chromosome 17q.
Linkage of early-onset familial breast and ovarian cancer to 11 markers on chromosome 17q12-q21 defines an 8-cM region which is very likely to include the disease gene BRCA 1. The most closely linked marker is D17S579, a highly informative CA repeat polymorphism. D17S579 has no recombinants with inherited breast or ovarian cancer in 79 informative meioses in the seven families with early-onset disease (lod score 9.12 at zero recombination). There is no evidence for linkage heterogeneity in the families with early-onset disease. The proportion of older-onset breast cancer attributable to BRCA 1 is not yet determinable, because both inherited and sporadic cases occur in older-onset families.
Hall
J M
JM
School of Public Health, University of California, Berkeley 94720.
Friedman
L
L
Guenther
C
C
Lee
M K
MK
Weber
J L
JL
Black
D M
DM
King
M C
MC
D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D002871:Chromosome Banding; D002886:Chromosomes, Human, Pair 17; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping
D005819:Genetic Markers; D009838:Oligodeoxyribonucleotides