title: Etiology, risk factors, epidemiology, and public health issues in melanoma and other cutaneous neoplasms.
abstract: The cytogenetic features of melanoma, including the contribution of specific genes, are beginning to be unraveled. Reproductive factors have been shown to have little relationship to melanoma. The puzzles over apparent systemic effects of exposure have persisted, however. Evidence was published that the history of reaction to sun exposure altered when a diagnosis of melanoma was made. An interesting suggestion was made that the classic melanoma risk factors are associated with promotion rather than initiation of the disease. There is further evidence that exposure decreases melanoma risk in people who tan well but increases it in those who do not. Also reviewed is the evidence that the ozone layer of the stratosphere began to decrease in thickness under the influence of the chlorofluorocarbon gasses.
authors.affiliation: University of Washington School of Public Health, Seattle.
authors.forename: J A
authors.initials: JA
authors.lastname: Lee
mesh_terms: D006370:Heliotherapy / Q000009:adverse effects; D006801:Humans; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D010126:Ozone; D011634:Public Health; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology
chemical_list: D010126:Ozone