[Toxic and drug-induced lesions of the pulmonary parenchyma].
Pulmonary tissue may be damaged by certain toxins or drugs in a dose-dependent way or by a hypersensitivity reaction. Pathological changes consist of a permeability pulmonary edema, an alveolar hemorrhage, an alveolitis and finally the formation of pulmonary fibrosis. Ingestion of the weed killer paraquat may induce a rapidly progressive and lethal form of fibrosing alveolitis, the inhalation of nitrous oxides may elicit lung edema. The most common drugs causing lung damage are cytotoxic agents, often used in combination, and the noncytotoxic drugs amiodarone and nitrofurantoin.
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Pneumologische Abteilung, Universitätsspital Zürich.
D000542:Alveolitis, Extrinsic Allergic / Q000139:chemically induced; D000970:Antineoplastic Agents / Q000009:adverse effects; D006540:Herbicides / Q000506:poisoning; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D009609:Nitrous Oxide / Q000009:adverse effects; D011042:Poisons; D011654:Pulmonary Edema / Q000139:chemically induced; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D012130:Respiratory Hypersensitivity / Q000209:etiology*
D000970:Antineoplastic Agents; D006540:Herbicides; D011042:Poisons; D009609:Nitrous Oxide
Toxische und durch Medikamente induzierte Lungenparenchymschäden.