Effect of thymus cell-conditioned medium on recovery of haemopoiesis destroyed by gamma radiation.
The effect of thymus cell-conditioned medium (TCCM) on haemopoiesis recovery in spleen, bone marrow and thymus was studied in mice injured by a single dose of 5.8 Gy of ionizing radiation. TCCM given 18 h before irradiation accelerated haemopoiesis recovery in splenic red pulp, and in part in bone marrow. Reparation of splenic white pulp and thymus was not influenced by TCCM application.
Macková
N
N
Department of Cellular and Molecular Biology, Faculty of Sciences, P.J. Safárik University, Kosice.
Fedorocko
P
P
Brezáni
P
P
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D003470:Culture Media; D005260:Female; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects*; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects*
D003470:Culture Media; D016298:Hematopoietic Cell Growth Factors