title: [Computed tomographic studies on density kinetics after the bolus injection and infusion of perfluorooctylbromide (PFOB). Animal experimental studies].
abstract: We investigated the enhancement of the liver, the spleen, and of induced abscesses and the abdominal vessels after administration of 3 g/kg bodyweight. Perfluorooctylbromide (PFOB) in an animal model. Twenty-one rabbits each received the contrast medium as bolus injection and as slow infusion over half an hour. CT was performed between 2 and 48 hours after contrast medium application. Peak enhancement of the liver, the spleen and the liver abscess membrane was found between 24 and 48 hours after PFOB administration, independently of the application mode. Peak enhancement of the abdominal aorta and the IVC was observed within two hours after bolus injection. In this rabbit model PFOB permits best delineation of the vessels after bolus injection within the first two hours, while CT imaging of the liver, the spleen and the liver abscess membrane is best between 24 and 48 hours after contrast medium application, independent of the injection velocity.
authors.affiliation: Klinik für Radiologische Diagnostik, RWTH Aachen.
authors.forename: G
authors.initials: G
authors.lastname: Adam
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
authors.forename: A
authors.initials: A
authors.lastname: Prescher
authors.forename: H
authors.initials: H
authors.lastname: Goertz
authors.forename: C
authors.initials: C
authors.lastname: Schiffer
authors.forename: K
authors.initials: K
authors.lastname: Bruchmüller
authors.forename: J
authors.initials: J
authors.lastname: Limmer
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004655:Emulsions; D004927:Escherichia coli Infections / Q000000981:diagnostic imaging; D005466:Fluorocarbons / Q000008:administration & dosage*; D006842:Hydrocarbons, Brominated; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008099:Liver / Q000000981:diagnostic imaging; D008100:Liver Abscess / Q000000981:diagnostic imaging; D011817:Rabbits; D011897:Random Allocation; D013154:Spleen / Q000000981:diagnostic imaging; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D003287:Contrast Media; D004655:Emulsions; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; C003072:perflubron
vernacular_title: Computertomographische Untersuchungen zur Dichtekinetik nach Bolusinjektion und Infusion von Perfluorooctylbromid (PFOB). Tierexperimentelle Untersuchungen.