title: Aminoglutethimide in malignant melanoma. A phase II study.
abstract: The role of steroid hormones has been suggested in the growth of malignant melanoma, and since aromatase activity has been found in melanoma tissue, we carried out a phase II study of aminoglutethimide, an aromatase inhibitor in malignant melanoma patients. Fifteen heavily pretreated patients entered the study. No response was observed--the treatment was well tolerated. We concluded that aminoglutethimide is very unlikely to be useful in melanoma patients.
authors.affiliation: Centre Oscar Lambret, BP 307-59020 Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Block
authors.forename: J
authors.initials: J
authors.lastname: Bonneterre
authors.forename: A
authors.initials: A
authors.lastname: Adenis
authors.forename: J M
authors.initials: JM
authors.lastname: Pion
authors.forename: A
authors.initials: A
authors.lastname: Demaille
mesh_terms: D000328:Adult; D000368:Aged; D000616:Aminoglutethimide / Q000627:therapeutic use*; D047072:Aromatase Inhibitors; D004341:Drug Evaluation; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged
chemical_list: D047072:Aromatase Inhibitors; D000616:Aminoglutethimide