[The effects of induced hypotension with sevoflurane and PGE1 on liver functions during neurosurgery].
The effects of induced hypotension with sevoflurane and PGE1 (Group S) on liver functions during neurosurgery that can avoid direct invasion of the liver were retrospectively studied in 35 cases, in comparison with 8 cases of isoflurane and PGE1 induced hypotension (Group I). GOT, GPT and gamma-GTP increased slightly in both groups 1 day and 1 week after operation, but they returned to preoperative levels 1 month later. ChE decreased in both groups, and the decrease was greater in group S. Three cases in Group S (8.6%) and one case in Group I (12.5%) showed GOT or GPT over 100 and there was no significant difference in the two groups. Hypotensive anaesthesia induced with sevoflurane and PGE1 in neurosurgery, as that induced with isoflurane and PGE1, has little effect on postoperative liver functions.
Hasegawa
J
J
Department of Anaesthesiology, Hiraka General Hospital, Yokote.
Mitsuhata
H
H
Matsumoto
S
S
Komatsu
H
H
Mizunuma
T
T
D000368:Aged; D000527:Alprostadil / Q000494:pharmacology*; D000777:Anesthetics; D001921:Brain / Q000601:surgery; D004987:Ethers; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled; D008099:Liver / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D000077149:Sevoflurane
D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D000527:Alprostadil