Tumor progression, biology, and host response in melanoma.
Malignant melanoma has provided an excellent model system for studying crucial events in human tumor development and progression. Important components discussed here include the independence of melanoma cells from exogenous growth factors due to self-stimulation and the altered adhesive properties and invasive capacity of these cells.
Menrad
A
A
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania.
Herlyn
M
M
D006133:Growth Substances / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000032:analysis; D008545:Melanoma / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D009361:Neoplasm Invasiveness
D006133:Growth Substances; D016023:Integrins