Neuronal migration on laminin in vitro.
Chick sympathetic (E-9) or telencephalic (E-7) neurons were cultured at low density on poly-DL-ornithine (PORN), poly-L-lysine (POLS), laminin or laminin-covered PORN or POLS and monitored with time-lapse videomicroscopy. Neurons migrated on laminin, or laminin-covered PORN or POLS, but not on PORN or POLS alone. Neuronal migration did not involve interactions with other cells indicating that neurons are capable of independent migration when exposed to a laminin substrate.
Liang
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S
Department of Neurosurgery, University of Cincinnati School of Medicine, OH 45267-0515.
Crutcher
K A
KA
D000818:Animals; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology; D002478:Cells, Cultured; D002642:Chick Embryo; D007797:Laminin / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology; D011107:Polylysine / Q000494:pharmacology; D014741:Video Recording
D007797:Laminin; D010455:Peptides; C008973:polyornithine; D011107:Polylysine