title: [Infiltrating carcinoma of the bladder: preliminary results of multidisciplinary protocols with radiotherapy and neoadjuvant chemotherapy].
abstract: Report on the evolution of a series of 64 patients with T2-4 N0-3 M0 infiltrant transitional carcinoma of the bladder, treated with TUR and radical cystectomy (28/62) or intra-operative radiotherapy (IOR) 15 Gy and external radiotherapy 40 Gy prior to cystectomy (34/62). The last group including 24 patients which received neo-adjuvant chemotherapy. Seventy percent (15 p0N-, 5 p0N+, 1 p1N-, 3 p1N+) patients treated with radiotherapy, with and without chemotherapy, had local response. Considering just the group which received IOR, external radiotherapy and co-adjuvant chemotherapy (24/34), the local response accounts for 79% (10 p0N-, 5 p0N+, 1 p1N-, 3 p1N+). Current survival of the group receiving concomitant multiple therapy is 92 +/- 5%, 75 +/- 9% and 57 +/- 11% at 1, 3 and 5 years; for equal intervals current survival of the group undergoing cystectomy is 57 +/- 9%, 46 +/- 9% and 40 +/- 10% (p = 0.02). The univariate analysis has confirmed that stage decrease is significantly more frequent in the group receiving radiotherapy with and without chemotherapy (p less than 0.001). Such a decrease significantly biased survival (p = 0.001). In the multivariate analysis, the variables with greater prognostic power were pre-surgical renal function (p less than 0.001), use of radiotherapy (p less than 0.001) and surgical complications (p less than 0.001). Preliminary results show a very high local response to multiple therapy which has been translated so far in increased survival.
authors.affiliation: Departamento de Urología, Facultad de Medicina, Universidad de Navarra.
authors.forename: F
authors.initials: F
authors.lastname: De Castro
authors.forename: P L
authors.initials: PL
authors.lastname: Sánchez
authors.forename: L G
authors.initials: LG
authors.lastname: Agüera
authors.forename: W A
authors.initials: WA
authors.lastname: Isa
authors.forename: J E
authors.initials: JE
authors.lastname: Robles
authors.forename: A
authors.initials: A
authors.lastname: Brugarolas
authors.forename: J J
authors.initials: JJ
authors.lastname: Zudaire
authors.forename: F A
authors.initials: FA
authors.lastname: Calvo
authors.forename: J M
authors.initials: JM
authors.lastname: Berián
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*
vernacular_title: Carcinoma vesical infiltrante: resultados prelimares de protocolos multidisciplinarios con radioterapia y quimioterapia neoadyuvante.