Effect of inoculum size on bacteriolytic activity of cefminox and four other beta-lactam antibiotics against Escherichia coli.
MICs and turbidimetric experiments revealed a negligible inoculum effect with two Escherichia coli strains exposed to cefminox and cefoxitin, whereas a marked inoculum effect was revealed after exposure to cefotaxime, ceftizoxime, and imipenem. The activities of the cephamycins were associated with spheroplast formation and bacteriolysis at concentrations close to the MIC, whereas the other agents induced the formation of filaments or, in the case of imipenem, rounded cells.
Soriano
F
F
Department of Microbiology, University Hospital, Queen's Medical Centre, Nottingham, United Kingdom.
Edwards
R
R
Greenwood
D
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests / Q000379:methods
D000900:Anti-Bacterial Agents; D002513:Cephamycins; C046079:cefminox