Molecular flypaper and atherosclerosis: structure of the macrophage scavenger receptor.
Macrophage scavenger receptors have been implicated both in the deposition of lipoprotein cholesterol in artery walls during the formation of atherosclerotic plaques and in host defense against pathogenic infections. The receptor's unusual ability to bind tightly to a very wide variety of ligands and its novel mosaic structure comprising alpha-helical coiled-coil, collagenous and cysteine-rich domains are described.
Krieger
M
M
Biology Department, Massachusetts Institute of Technology, Cambridge 02139.
D001161:Arteriosclerosis / Q000209:etiology*; D003545:Cysteine; D006801:Humans; D008024:Ligands; D008264:Macrophages / Q000378:metabolism*; D008565:Membrane Proteins; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000378:metabolism*; D011973:Receptors, LDL / Q000737:chemistry / Q000378:metabolism*; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D012091:Repetitive Sequences, Nucleic Acid; D051122:Scavenger Receptors, Class B
D008024:Ligands; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D003545:Cysteine