Species differences in the nephrotoxic response to S-(1,2-dichlorovinyl)glutathione.
The present study was carried out to investigate the species differences in the nephrotoxic response to S-(1,2-dichlorovinyl)glutathione (DCVG) using rats, hamsters and guinea-pigs. DCVG was given intraperitoneally in physiological saline to groups of 5 animals at doses 0, 165 and 330 mumol/kg. Urine was collected for 24 h and the animals were then sacrificed. Significantly increased levels of urinary glucose, N-acetyl-beta-D-glucosaminidase, gamma-glutamyl transpeptidase, proteins and blood urea nitrogen were observed in rats at both dose levels of DCVG. An increase, but not of similar magnitude, of these biochemical parameters was noted in hamsters only at the higher dose of DCVG. Guinea-pigs showed significant increases in these biochemical parameters at the lower dose, but not at the higher dose. Light-microscopic studies showed increasing proximal tubular necrosis (PTN) in rats with increasing dose of DCVG, but PTN involving straight tubules only was observed at the higher dose in hamsters. PTN was again observed in guinea-pigs at the lower dose, but not at the higher dose of DCVG.
Chakrabarti
S
S
Département de Médecine du Travail et Hygiène du Milieu, Faculté de Médecine, Université de Montréal, Québec, Canada.
Malick
M A
MA
Denniel
C
C
Greselin
E
E
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000031:analogs & derivatives* / Q000633:toxicity; D006029:Glycosuria / Q000378:metabolism; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000201:enzymology / Q000652:urine; D007679:Kidney Medulla / Q000187:drug effects / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced; D008297:Male; D009336:Necrosis; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity
C041464:S-(1,2-dichlorovinyl)glutathione; D000118:Acetylglucosaminidase; D005978:Glutathione