Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations.
Vigabatrin and (S)-4-allenylGABA (MDL 72483), two anticonvulsant GABA-T inhibitors, partially antagonize phencyclidine (PCP)-induced hyperactivity in mice at doses that do not affect spontaneous motor activity. The PCP antagonism is related to whole-brain GABA concentrations. The results indicate the potential use of GABA-T inhibitors in the therapy of PCP intoxications and perhaps also in the treatment of certain forms of endogenous psychoses.
Seiler
N
N
Marion Merrell Dow Research Institute, Strasbourg, France.
Grauffel
C
C
D000614:Aminocaproates / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D010622:Phencyclidine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D000614:Aminocaproates; D000927:Anticonvulsants; D005231:Fatty Acids, Unsaturated; D005680:gamma-Aminobutyric Acid; C072694:4-amino-5,6-heptadienoic acid; D020888:Vigabatrin; D010622:Phencyclidine