title: Cognitive functioning, ASP, and family history of alcoholism in young men at risk for alcoholism.
abstract: Previous research has suggested that individuals with a family history of alcoholism may have cognitive deficits that predate, and possibly predispose, to the onset of alcoholism. However, these deficiencies may result from other factors, e.g., comorbid psychopathology. The current study investigated the neuropsychological functioning of young adult males at high risk for alcohol abuse due to a family history of alcoholism (FH) and/or a personal history of antisocial personality disorder (ASP). A family history of alcoholism (FH+) alone was not associated with neuropsychological impairment. Subjects with ASP, however, exhibited some difficulty with higher level motor control and with verbal concept formation compared with nonASP subjects. No clear pattern of FH x ASP interaction was evident in the measures examined. These findings suggest that previous findings suggesting cognitive deficiencies in FH+ individuals may have been related to a failure to consider co-morbid ASP. The deficits exhibited by the ASP subjects may reflect both reduced inhibitory control and a deficiency in higher level verbal skills. These deficiencies may leave ASP individuals less capable of utilizing higher level language skills to regulate behavior.
authors.affiliation: Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030.
authors.forename: R
authors.initials: R
authors.lastname: Gillen
authors.forename: V
authors.initials: V
authors.lastname: Hesselbrock
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D016241:Child of Impaired Parents / Q000523:psychology*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007360:Intelligence / Q000187:drug effects; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011594:Psychometrics; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology
chemical_list: D000431:Ethanol