Subdermal penetration of topically applied clobetasol propionate in ointment base through intact human skin: lack of effect on subcutaneous adipose tissue blood flow.
Some data have demonstrated a substantial subdermal accumulation of topically applied drugs in animals. The aim of this study was to evaluate a possible effect of epicutaneously applied clobetasol propionate on blood flow in human subcutaneous adipose tissue. Nine healthy subjects were studied. The 133Xenon wash-out method was used for the measurement of subcutaneous blood flow. Resting blood flow and the local blood flow regulatory mechanisms, autoregulation of blood flow and the veno-arteriolar reflex, were assessed prior to treatment and were measured following 24, 48 and 72 h of treatment. The results demonstrated no effect of clobetasol propionate on resting subcutaneous blood flow or the local regulatory mechanisms.
Petersen
L J
LJ
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University of Copenhagen, Denmark.
Sindrup
J H
JH
Kristensen
J K
JK
D000273:Adipose Tissue / Q000098:blood supply* / Q000187:drug effects; D000287:Administration, Topical; D000328:Adult; D002990:Clobetasol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009824:Ointments; D012039:Regional Blood Flow / Q000187:drug effects; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects*; D012879:Skin Physiological Phenomena; D013997:Time Factors; D014980:Xenon Radioisotopes
D009824:Ointments; D014980:Xenon Radioisotopes; D002990:Clobetasol