In vivo muscle 31P nuclear magnetic resonance spectroscopy during treatment of halothane-sensitive and halothane-nonsensitive pigs.
In vivo muscle 31P nuclear magnetic resonance spectroscopy was performed on 10 female pigs originating from a homozygous halothane-sensitive line and on 10 female pigs from a homozygous halothane-nonsensitive line. The mean concentration of phosphocreatine in the biceps femoris muscle of the anesthetized pigs decreased to 86% of the initial value after 11 minutes of halothane exposure (3%, oxygen flow 3 L/min). After the next 5.6 minutes, phosphocreatine concentration reached a minimal value of 52%, followed by a mean recovery to 76% of the initial value during the ensuing 11 minutes. Response was not observed in anesthetized homozygous halothane-nonsensitive pigs. Thus, a decrease to 86% of the initial value of phosphocreatine was 100% predictive for homozygous halothane-sensitive pigs with body weight ranging from 10 to 18 kg.
Geers
R
R
Laboratory for Agricultural Buildings Research, Catholic University Leuven, Belgium.
Decanniere
C
C
Villé
H
H
Van Hecke
P
P
Goedseels
V
V
Vanstapel
F
F
Bosschaerts
L
L
De Ley
J
J
Zhang
W
W
Janssens
S
S
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D009682:Magnetic Resonance Spectroscopy; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000662:veterinary*; D009132:Muscles / Q000737:chemistry*; D010725:Phosphocreatine / Q000032:analysis*; D013552:Swine; D013553:Swine Diseases / Q000175:diagnosis*
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D006221:Halothane