title: Enhanced selectivity of the isolation of basic drugs from body fluids by means of extraction minicolumns and sophisticated elution schemes.
abstract: The paper presents results and experience obtained in the isolation of a number of basic polar/non-polar solutes (drugs, their metabolites and structural derivatives) from biological samples by using the separation minicolumns Separcol SI and Separcol SI C18 L/T. The aim was to provide insight into some simple procedures yielding optimal selectivity/specificity of the isolation of the studied solutes either by proper selection of the sorbent or by applying sophisticated elution schemes which use to advantage different properties of the eluents/solvents.
authors.affiliation: Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
authors.forename: L
authors.initials: L
authors.lastname: Soltés
mesh_terms: D001826:Body Fluids / Q000737:chemistry*; D002853:Chromatography, Liquid; D002855:Chromatography, Thin Layer; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D012463:Saliva / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004364:Pharmaceutical Preparations