Studies on the mechanisms of HTLV-I leukemogenesis.
The factors that regulate low viral expression and long latency after HTLV-I infection are poorly understood. To study the possible mechanisms involved in the regulation of gene expression and cell transformation, we studied whether (1) methylation could play a role in viral transcription, and (2) tax product could favor chromosomal instability. The results indicate that methylation of HTLV-I LTRs blocks their transcriptional activity and that tax protein triggers DNA damage.
Saggioro
D
D
Institute of Oncology, University of Padova, Italy.
Majone
F
F
Forino
M
M
Turchetto
L
L
Chieco-Bianchi
L
L
D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004249:DNA Damage; D016355:Genes, pX / Q000502:physiology*; D015490:HTLV-I Infections / Q000150:complications* / Q000235:genetics; D006801:Humans; D015458:Leukemia, T-Cell / Q000209:etiology* / Q000235:genetics; D008745:Methylation / Q000187:drug effects; D015162:Micronucleus Tests; D010957:Plasmids / Q000235:genetics*; D013755:Tetradecanoylphorbol Acetate; D014158:Transcription, Genetic / Q000235:genetics*; D014162:Transfection; D014407:Tumor Cells, Cultured
D013755:Tetradecanoylphorbol Acetate