Benzpyrene exposure at 15 days of prenatal life reduces the binding capacity of thymic glucocorticoid receptors in adulthood.
1. The offspring of female rats treated with a single dose of benzpyrene on day 15 of gestation showed in adulthood a significant relative decrease in the number of thymic glucocorticoid receptors, without an appreciable decrease in binding affinity. 2. There is experimental evidence that exposure to a hormone analogue in the early stage of organogenesis effects receptor development and the maternal organism fails to confer protection against that untoward influence.
Csaba
G
G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
A
A
D000818:Animals; D001580:Benzopyrenes / Q000008:administration & dosage / Q000633:toxicity*; D001665:Binding Sites; D001667:Binding, Competitive; D003907:Dexamethasone / Q000378:metabolism; D005260:Female; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism*
D001580:Benzopyrenes; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone