title: Formation of endovasal structures and intramural channels in rat vena cava after application of microsurgical suture: prophylactic effect of heparin and trental administration.
abstract: The study addresses the histopathology of end-to-end microanastomosis in the rat inferior vena cava. The vessels were harvested in 4 hours and 1, 3, 7, 14, and 30 days after the operation and were evaluated using light, scanning, and transmission electron microscopy. The endothelium was completely restored within 7 days after the surgical procedure. Endovasal structures at the microsuture site and intramural endothelial channels opening into the vena cava lumen developed as a result of endothelialization and parallel substitution of the three-dimensional fibrin framework of the mural microthrombus with connective tissue. By 1 month, aggregates of platelets, fibrin, and adhering leukocytes were observed in the intramural channel mouths. Administration of heparin and Trental for 1 week after the operation reduced the number of intramural channels and prevented the formation of endovasal structures at the site of microvenous anastomosis.
authors.affiliation: Laboratory of Electron Microscopy, Ivanovo Medical Institute, Russian Republic.
authors.forename: S L
authors.initials: SL
authors.lastname: Vyalov
authors.forename: M D
authors.initials: MD
authors.lastname: Rekhter
authors.forename: V B
authors.initials: VB
authors.lastname: Sidorov
authors.forename: K P
authors.initials: KP
authors.lastname: Pshenisnov
authors.forename: A A
authors.initials: AA
authors.lastname: Mironov
mesh_terms: D000714:Anastomosis, Surgical / Q000295:instrumentation; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D003238:Connective Tissue / Q000473:pathology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D005337:Fibrin; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D008855:Microscopy, Electron, Scanning; D008866:Microsurgery / Q000295:instrumentation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D010431:Pentoxifylline / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011921:Rats, Inbred WKY; D012038:Regeneration / Q000187:drug effects; D013537:Sutures; D013927:Thrombosis / Q000503:physiopathology* / Q000517:prevention & control; D014682:Vena Cava, Inferior / Q000187:drug effects / Q000473:pathology* / Q000601:surgery*
chemical_list: D005337:Fibrin; D006493:Heparin; D010431:Pentoxifylline