title: Alternatives to Aroclor 1254-induced S9 in in vitro genotoxicity assays.
abstract: A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity assays, with the aims of considering whether a replacement for Aroclor in its role in general screening assays could be readily identified. The working party concluded that there was sufficient support in the literature to justify the use of an appropriate phenobarbital/beta-naphthoflavone regime as an acceptable alternative to Aroclor.
authors.affiliation: ICI Central Toxicology Laboratory, Macclesfield, UK.
authors.forename: B M
authors.initials: BM
authors.lastname: Elliott
authors.forename: R D
authors.initials: RD
authors.lastname: Combes
authors.forename: C R
authors.initials: CR
authors.lastname: Elcombe
authors.forename: D G
authors.initials: DG
authors.lastname: Gatehouse
authors.forename: G G
authors.initials: GG
authors.lastname: Gibson
authors.forename: J M
authors.initials: JM
authors.lastname: Mackay
authors.forename: R C
authors.initials: RC
authors.lastname: Wolf
mesh_terms: D001140:Aroclors; D001571:Benzoflavones; D020111:Chlorodiphenyl (54% Chlorine); D008110:Liver Extracts; D009152:Mutagenicity Tests / Q000379:methods; D010634:Phenobarbital; D006113:United Kingdom; D019324:beta-Naphthoflavone
chemical_list: D001140:Aroclors; D001571:Benzoflavones; D008110:Liver Extracts; D020111:Chlorodiphenyl (54% Chlorine); D019324:beta-Naphthoflavone; D010634:Phenobarbital