title: A second envelope glycoprotein mediates neutralization of a pestivirus, hog cholera virus.
abstract: Several monoclonal antibodies (MAbs) raised against hog cholera virus (HCV) reacted with the HCV structural glycoprotein gp44/48 and neutralized the virus. The presence of HCV gp44/48 on the viral surface was directly demonstrated by immunogold electron microscopy. Eight anti-HCV gp44/48 MAbs were tested by immunoperoxidase assay against a panel of pestivirus strains. Each MAb showed a distinct pattern of reactivity with HCV strains. It is suggested that the MAbs are well suited for epidemiological investigations of HCV outbreaks.
authors.affiliation: Federal Research Centre for Virus Diseases of Animals, Tübingen, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Weiland
authors.forename: R
authors.initials: R
authors.lastname: Ahl
authors.forename: R
authors.initials: R
authors.lastname: Stark
authors.forename: F
authors.initials: F
authors.lastname: Weiland
authors.forename: H J
authors.initials: HJ
authors.lastname: Thiel
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D006691:Classical Swine Fever / Q000175:diagnosis; D006692:Classical Swine Fever Virus / Q000276:immunology*; D005069:Evaluation Studies as Topic; D005455:Fluorescent Antibody Technique; D014644:Genetic Variation; D006023:Glycoproteins / Q000276:immunology*; D016253:Microscopy, Immunoelectron; D012703:Serotyping; D013552:Swine; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; C074547:Classical swine fever virus glycoprotein gp44-48; D006023:Glycoproteins; D014764:Viral Proteins