Anticonvulsant effect of liposome-entrapped superoxide dismutase in amygdaloid-kindled rats.
Amygdaloid-kindled rats received intravenous human copper-zinc superoxide dismutase (CuZn-SOD) either in free form or entrapped within liposomes (SOD-L), at 5, 10 or 20 mg/kg. The animals were stimulated at the generalized seizure-triggering threshold 5 min, 2 h and then every 24 h after the drug was given, until 5 consecutive stage 5 seizures were induced. Free CuZn-SOD had little or no effect. However, SOD-L, particularly at 10 mg/kg, had a prolonged anticonvulsant effect, although there was great individual variation in the onset and duration of seizure suppression. This effect of SOD-L may be due to the ability of liposomes to act as a depot for the sustained release of drugs.
Yokoyama
H
H
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Mori
N
N
Osonoe
K
K
Ishida
S
S
Kumashiro
H
H
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D004337:Drug Carriers; D007696:Kindling, Neurologic / Q000187:drug effects*; D008081:Liposomes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000008:administration & dosage*
D000927:Anticonvulsants; D004337:Drug Carriers; D008081:Liposomes; D013482:Superoxide Dismutase