The role of cytosolic Ca2+ in cell injury, necrosis and apoptosis.
Increases in cytosolic Ca2+ are believed to be a pivotal signal in the regulation of cell injury, cell death, cell proliferation, cellular differentiation and cellular aging. Changes in the concentration of cytosolic Ca2+ are involved in both acute and chronic cell injury, as well as in accidental or programmed cell death. Signalling in all of these phenomena is dependent on mediated activities of a number of intracellular factors, including phospholipases, proteases and endonucleases. The coordinate regulation of these factors, as well as of oncogene activation, seems to play a role both in the processes of cell injury and cell death, and in the recovery from injury in sublethally injured cells.
Trump
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University of Maryland, Baltimore.
Berezesky
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D000818:Animals; D002118:Calcium / Q000378:metabolism*; D016923:Cell Death / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D003600:Cytosol / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D006801:Humans; D009336:Necrosis
D004247:DNA; D002118:Calcium