title: Chemistry of peptide interactions with MHC proteins.
abstract: X-ray crystallographic and peptide-MHC binding studies have begun to clarify the interaction between antigenic peptides and MHC proteins at the molecular level. At the same time, our understanding of the mechanisms of peptide-MHC interactions in physiologic cellular conditions has been significantly expanded by the isolation and characterization of naturally processed antigenic peptides.
authors.affiliation: Cytel, San Diego, California.
authors.forename: A
authors.initials: A
authors.lastname: Sette
authors.forename: H M
authors.initials: HM
authors.lastname: Grey
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D000941:Antigens / Q000276:immunology / Q000378:metabolism*; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006680:HLA Antigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D015796:HLA-B27 Antigen / Q000378:metabolism / Q000648:ultrastructure; D006649:Histocompatibility Antigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D000949:Histocompatibility Antigens Class II / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008954:Models, Biological; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D014961:X-Ray Diffraction
chemical_list: D000941:Antigens; D006680:HLA Antigens; D015796:HLA-B27 Antigen; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments; D010743:Phospholipids