[The radiosensitivity of hematopoietic stem cells from mice forming splenic colonies after 8 and 12 days following bone marrow cell transplantation (CFU-S-8 and CFU-S-12)].
The method of "macro-" and "microcolonies" was used to study the radiosensitivity of CFU-S that form "early" (8 days) and "late" (12 days) splenic colonies after transplantation of syngeneic bone marrow to fatally exposed mice: no significant differences were found. Median lethal doses (D0) for CFU-S-8 and CFU-S-12 were 1.03 and 1.13 Gy for "microtest" and 0.99 and 1.16 Gy for "microtest" respectively.
Trishkina
A I
AI
Konopliannikov
A G
AG
D000818:Animals; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000528:radiation effects*; D051379:Mice; D008808:Mice, Inbred CBA; D011836:Radiation Tolerance; D013154:Spleen / Q000166:cytology / Q000528:radiation effects*; D013997:Time Factors; D014185:Transplantation, Isogeneic
Radiochuvstvitel'nost' stvolovykh krovetvornykh kletok mysheĭ, formiruiushchikh selezenochnye kolonii cherez 8 i 12 sutok posle transplantatsii kletok kostnogo mozga (KOEs-8 i KOEs-12).