Regulation of the expression of adhesion molecules by human synoviocytes.
The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1 beta greater than tumor necrosis factor-alpha, interferon-gamma much greater than interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.
Lindsley
H B
HB
Department of Medicine, University of Kansas Medical Center, Kansas City.
Smith
D D
DD
Davis
L S
LS
Koch
A E
AE
Lipsky
P E
PE
D015815:Cell Adhesion Molecules / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D013583:Synovial Membrane / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism
D015815:Cell Adhesion Molecules