title: [Propofol and alfentanil in total intravenous anesthesia].
abstract: We studied 22 patients undergoing total intravenous anaesthesia for both abdominal and superficial surgery. Anaesthesia has been induced and maintained with propofol (1 mg/kg in 20 seconds; 10 mg/kg/h for 10 minutes; 8 mg/kg/h for 10 minutes; 6 mg/kg/h until the end of the operation) and alfentanil (15 mg/kg before the induction and boli of 10-30 mg/kg in the presence of insufficient surgical analgesia). All the patients have been intubated after the administration of vecuronium 0.1 mg/kg, and artificially ventilated with air and oxygen (FiO2 0.4). We observed: 1) haemodynamic stability after the intubation and during surgery; 2) easy control of surgical analgesia; 3) early postoperative recovery, with no correlation with the doses of propofol and alfentanil; 4) absence of postoperative respiratory depression; 5) intraoperative amnesia; 6) low incidence of postoperative side effects. We conclude that, by virtue of the pharmacokinetic characteristics of propofol and alfentanil, most limitations of total intravenous anaesthesia have been overcome.
authors.affiliation: Istituto Pluridisciplinare di Anestesiologia, Rianimazione e Terapia Intensiva, Università degli Studi di Messina.
authors.forename: F S
authors.initials: FS
authors.lastname: Venuti
authors.forename: M
authors.initials: M
authors.lastname: Curatolo
authors.forename: A U
authors.initials: AU
authors.lastname: Sinardi
authors.forename: L B
authors.initials: LB
authors.lastname: Santamaria
authors.forename: A
authors.initials: A
authors.lastname: Orlando
authors.forename: C
authors.initials: C
authors.lastname: Praticò
authors.forename: A
authors.initials: A
authors.lastname: David
authors.forename: S
authors.initials: S
authors.lastname: Montanini
mesh_terms: D000328:Adult; D015760:Alfentanil / Q000008:administration & dosage* / Q000494:pharmacology; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D015760:Alfentanil; D015742:Propofol
vernacular_title: Propofol e alfentanil in anestesia endovenosa totale.