title: Evaluation of vasomotor reactivity by transcranial Doppler and acetazolamide test before and after extracranial-intracranial bypass in patients with internal carotid artery occlusion.
abstract: OBJECTIVE
  The aim of this trial was to evaluate the effectiveness of extracranial-intracranial bypass with respect to vasomotor reactivity in patients with internal carotid artery occlusions and absent vasomotor reactivity, comparing them with a control group treated conservatively.
  
  
  METHODS
  To test vasomotor reactivity in 104 patients with unilateral occlusion of the internal carotid artery, we measured blood flow velocity in the middle cerebral artery by transcranial Doppler sonography both at rest and after injection of acetazolamide. Among the 39 patients who failed to show increased mean blood flow velocity after the acetazolamide test distal to an occluded internal carotid artery by greater than or equal to 10%, 14 subjects subsequently underwent extracranial-intracranial bypass surgery (group A) and 14 age- and sex-matched subjects in whom no such procedure was done composed the control group (group B). Follow-up examinations were performed 3-6 months postoperatively and in the control group 3-6 months after initial examination.
  
  
  RESULTS
  Baseline values of the mean blood flow velocity at rest on the affected side were reduced in both groups compared with the contralateral healthy side (group A, 46.0 +/- 15.1 cm/sec; group B, 48.1 +/- 16.7 cm/sec) and revealed only a marginal increase after acetazolamide. The contralateral side showed a normal blood flow velocity at rest and an adequate response to acetazolamide in both groups. On the follow-up examination group A demonstrated a normalized vasodilatory capacity. Blood flow velocity increased significantly after acetazolamide from 41.9 +/- 13.1 cm/sec to 53.5 +/- 16.0 cm/sec (p less than 0.002). In group B, the compromised vasomotor reactivity remained unchanged.
  
  
  CONCLUSIONS
  Our results demonstrate that transcranial Doppler sonography together with the acetazolamide test can identify subjects with reduced vasomotor reactivity distal to an occluded internal carotid artery, who may improve hemodynamically by an extracranial-intracranial bypass.
authors.affiliation: Department of Internal Medicine, Krankenanstalt Rudolfstiftung, Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Karnik
authors.forename: A
authors.initials: A
authors.lastname: Valentin
authors.forename: H P
authors.initials: HP
authors.lastname: Ammerer
authors.forename: P
authors.initials: P
authors.lastname: Donath
authors.forename: J
authors.initials: J
authors.lastname: Slany
mesh_terms: D000086:Acetazolamide; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D002548:Cerebral Revascularization; D002560:Cerebrovascular Circulation; D004453:Echoencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D014666:Vasomotor System / Q000503:physiopathology*
chemical_list: D000086:Acetazolamide