[Genetic disposition of atherosclerosis? Case report of a monozygotic pair of twins].
The case of a 64-year old pair of monozygotic male twins with atherosclerotic disease of the iliaca arteries is described and the related literature dealing with the genetics of atherosclerosis is reviewed. Both patients had corresponding clinical history and physical findings and showed an almost identically localised and a high degree of stenosis of the right iliac artery of similar appearance. In both cases percutaneous transluminal angioplasty (PTA) was performed prior to placement of Plamaz stents. The well-known risk factors of atherosclerosis are hypertension, hypercholesterolaemia, cigarette smoking, diabetes mellitus, obesity, physical inactivity, and psychosocial influences. However, a number of atherosclerotic lesions cannot be accounted for solely on the basis of current knowledge of these risk factors. The reported case produces evidence of genetic factors as contributing components in the pathogenesis of established atherosclerotic disease.
Dommaschk
J
J
Institut und Poliklinik für Radiologische Diagnostik, Universität Köln.
Gross-Fengels
W
W
Fischbach
R
R
D001161:Arteriosclerosis / Q000235:genetics*; D006801:Humans; D007083:Iliac Artery; D008297:Male; D008875:Middle Aged; D014430:Twins, Monozygotic
Genetische Disposition der Atherosklerose? Beobachtungen bei einem monozygoten Zwillingspaar.