title: Long-term follow-up of 92 patients with locally advanced follicular or papillary thyroid cancer after combined treatment.
abstract: Between 1960 and 1988, 92 patients with a locally advanced follicular or papillary thyroid cancer have been treated with surgery and radiotherapy consisting of iodine-131 or external (ext RT) radiotherapy or both. Locoregional control in patients less than 38 years of age at diagnosis and in older patients with a papillary cancer and a macroscopically complete resection was 100% with or without ext RT. Locoregional control in patients 38 years of age or older and without palpable postsurgical residual mass was 89% with ext RT and 60% without. In patients with a palpable residual mass, one of ten treated with iodine-131 alone had a permanent local control compared to six of 14 treated with addition of ext RT. Published data concerning iodine-131 and ext RT in the treatment of locally advanced follicular or papillary thyroid cancer are discussed. Routine surgery in our region consists of a near total thyroid resection, followed by iodine-131 ablation of the remnant thyroid. In younger patients with a limited T4 tumour and complete resection, we do not use ext RT. In all older patients with a T4 tumour as well as in younger patients with an extensive T4 tumour, ext RT is added.
authors.affiliation: Departement Medizinische Radiologie, Universitätsspital Zürich.
authors.forename: C
authors.initials: C
authors.lastname: Glanzmann
authors.forename: U M
authors.initials: UM
authors.lastname: Lütolf
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000628:therapy; D000328:Adult; D000367:Age Factors; D002291:Carcinoma, Papillary / Q000401:mortality* / Q000628:therapy; D002423:Cause of Death; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000628:therapy; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000706:statistics & numerical data; D012189:Retrospective Studies; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000401:mortality* / Q000628:therapy; D013965:Thyroidectomy / Q000706:statistics & numerical data
chemical_list: D007457:Iodine Radioisotopes