title: Familial history of cardiovascular disease and blood lipid pattern in newborn infants.
abstract: The levels of atherogenic lipid fractions are higher in children with a family history of ischemic cardiovascular disease (CD). This study was designed to examine this relationship in neonates. A total of 1276 newborns were investigated; 400 cord blood samples were collected for measurement of triglycerides (TG), total cholesterol (TC), LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C); on day 4, 1200 capillary samples were taken for TC and TG measurements. Male newborns with a positive history of CD had higher concentrations of cord blood TC (P less than 0.04) and LDL-C (P less than 0.02). On day 4 this difference in TC was no longer detectable (LDL-C not determined). A coronary heart disease (CHD) risk factor family history is sensitive (0.87) in predicting high cord blood concentrations of LDL-C, the specificity being 0.46 and the positive predicting value 0.08.
authors.affiliation: Department of Pediatrics V, University of Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Bellù
authors.forename: M T
authors.initials: MT
authors.lastname: Ortisi
authors.forename: C
authors.initials: C
authors.lastname: Agostoni
authors.forename: P
authors.initials: P
authors.lastname: Incerti
authors.forename: R
authors.initials: R
authors.lastname: Besana
authors.forename: E
authors.initials: E
authors.lastname: Riva
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol