title: Effectiveness of continuously infused DTPA therapy in reducing the radiation dose from inhaled 244Cm2O3 aerosols.
abstract: Radionuclide decorporation is the only effective method of reducing radiation dose for persons contaminated accidentally. In this study, dogs that had inhaled a moderately soluble aerosol of 244Cm2O3 were treated with either discrete intravenous injections of the chelating agent diethylenetriaminepentaacetic acid (Zn-DTPA) or with subcutaneous infusion of Zn-DTPA at either 30 or 120 mumol kg-1 d-1. Each treatment regimen was continued for 64 d, whereupon all animals were killed, and collected excreta and tissue samples were analyzed for curium. All DTPA treatment methods were effective. A total of 89% of the initial pulmonary burden (IPB) was removed by DTPA injection, whereas 94% IPB was removed by the low dose of infused DTPA and 97% by the high dose treatment. Thus, low and high infused doses of DTPA prevented the translocation of greater than 99.5% of curium to liver and 97-99% to bone and kidney. The resultant dose reductions to these organs were superior to those achieved by intravenous DTPA injections.
authors.affiliation: Inhalation Toxicology Research Institute, Albuquerque, NM 87185.
authors.forename: R A
authors.initials: RA
authors.lastname: Guilmette
authors.forename: B A
authors.initials: BA
authors.lastname: Muggenburg
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D015913:Chelation Therapy; D003476:Curium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D005260:Female; D015918:Infusion Pumps, Implantable; D007263:Infusions, Parenteral; D008297:Male; D004369:Pentetic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000517:prevention & control
chemical_list: D000336:Aerosols; C026884:curium oxide; D004369:Pentetic Acid; D003476:Curium