Secretion of macrophage fusion factor (MFF) by schistosome egg granulomas maintained in vitro.
The schistosome granuloma cultured in vitro under antigenic specific and unspecific stimulation releases macrophage fusion factor (MFF) into the medium, adjusting the production dynamics to the spontaneous modulation model already described. These findings demonstrate the feasibility of studying granulomatous response in mammalian schistosomiasis utilizing an in vitro model of lymphokine granuloma secretion.
Rodriguez-Acosta
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Universidad Central de Venezuela, Instituto de Medicina Tropical, Caracas.
Girón
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ME
Aguilar
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D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D006099:Granuloma / Q000276:immunology* / Q000469:parasitology; D006168:Guinea Pigs; D015801:Helminth Proteins; D066298:In Vitro Techniques; D008109:Liver Diseases, Parasitic / Q000276:immunology*; D008222:Lymphokines / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010063:Ovum / Q000276:immunology; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology
D000947:Antigens, Helminth; D015801:Helminth Proteins; D008222:Lymphokines; C055560:p40 egg antigen, Schistosoma