Studies on iridoids of tissue cultures of Penstemon serrulatus: isolation and their antiproliferative properties.
Penstemide and serrulatoloside as well as penstemide aglycone and serrulatoloside aglycone were isolated and identified in the calli and suspension cultures of Penstemon serrulatus. The influence of serrulatoloside, penstemide, and its aglycone on the spontaneous proliferation of mouse spleen lymphocytes or hepatoma cells in the Syrian hamster has been estimated in vitro. It has been found that these compounds produce a dose-dependent inhibition of [3H]-thymidine incorporation into the DNA of the examined cells.
Wysokińska
H
H
Department of Botany, Medical Academy, Lódź, Poland.
Skrzypek
Z
Z
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D006224:Cricetinae; D046508:Culture Techniques; D004247:DNA / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D008114:Liver Neoplasms, Experimental; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D011714:Pyrans / Q000302:isolation & purification / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured
D011714:Pyrans; D004247:DNA; D013936:Thymidine