Hemi-naevus of Ota: perturbation of neural crest differentiation as a likely mechanism.
We present a case of oculodermal melanosis that involves the lower eyelid and lower half of the globe in a very clearly defined fashion. We suggest that such a lesion is the result of a local change in embryonic environment occurring during a well-defined stage of ocular development, such that differentiation of neural crest cells into a melanocytic phenotype is favoured.
Benson
M T
MT
Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Rennie
I G
IG
D000328:Adult; D002455:Cell Division; D005123:Eye / Q000196:embryology; D005134:Eye Neoplasms / Q000473:pathology*; D005142:Eyelid Neoplasms / Q000473:pathology*; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D015811:Iris Neoplasms / Q000473:pathology; D008548:Melanosis / Q000473:pathology; D009432:Neural Crest / Q000473:pathology; D009507:Nevus of Ota / Q000473:pathology*