Malignant paraganglioma of the uterus.
We report a malignant uterine paraganglioma in a 40-year-old female, who died 7 months after the initial diagnosis. On light microscopy the tumour showed a typical zellballen pattern as well as a pronounced cellular pleomorphism. In many tumour cells hyaline globules were demonstrated within the cytoplasm. Immunohistochemically the lesion was characterized by the presence of neuron-specific enolase, protein gene product 9.5 and synaptophysin, and electron microscopically by the occurrence of neurosecretory granules.
Beham
A
A
Institute of Pathology, University of Graz Medical School, Austria.
Schmid
C
C
Fletcher
C D
CD
Auböck
L
L
Pickel
H
H
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D010235:Paraganglioma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure