title: Neuroendocrine, fluid balance, and thirst responses to alcohol in alcoholics.
abstract: This study simultaneously evaluated multiple circulating neurohormones, osmolality, thirst, and fluid balance in eight actively drinking, alcoholic males and seven controls before and 12 hr after an ethanol challenge. Basal levels of serum osmolality and thirst were significantly higher in alcoholics compared with controls, yet actively drinking alcoholics at the start of the study had normal vasopressin (AVP) levels, plasma angiotensin II (Ang II), plasma renin activity, plasma aldosterone (Aldo), and plasma catecholamines. In response to ethanol, serum osmolalities rose significantly higher while plasma AVP levels became significantly suppressed in alcoholics. After the ethanol stimulus, plasma Ang II levels of alcoholics were significantly higher than those of controls at 11 AM (12.15 +/- 4.49 vs. 1.83 +/- 0.6 pg/ml, p less than 0.02) and 12 noon (14.93 +/- 6.81 vs. 1.37 +/- 0.17 pg/ml, p less than 0.04). Neither plasma renin activity nor Aldo changed in accordance with the elevated plasma Ang II in alcoholics. Diuresis in the alcoholics, assessed by the sum of urine output following the challenge dose, was significantly less than that of controls. Thirst scores and fluid intakes after the ethanol challenge did not differ between alcoholics and controls. The lack of an Ang II-mediated increase in plasma Aldo or thirst response suggests that ethanol may have a specific blunting effect on Ang II receptors. This study demonstrates that ethanol can be used as a provocative test in chronic alcoholics to uncover aberrant hormonal responses for two systems, namely, Ang II and AVP.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Psychiatry, Cleveland Clinic Foundation, OH 44195-5189.
authors.forename: G B
authors.initials: GB
authors.lastname: Collins
authors.forename: K B
authors.initials: KB
authors.lastname: Brosnihan
authors.forename: R A
authors.initials: RA
authors.lastname: Zuti
authors.forename: M
authors.initials: M
authors.lastname: Messina
authors.forename: M K
authors.initials: MK
authors.lastname: Gupta
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000503:physiopathology; D000437:Alcoholism / Q000503:physiopathology*; D000804:Angiotensin II / Q000097:blood*; D001127:Arginine Vasopressin / Q000097:blood*; D004837:Epinephrine / Q000097:blood*; D000431:Ethanol / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D013894:Thirst / Q000187:drug effects* / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000187:drug effects* / Q000502:physiology
chemical_list: D000804:Angiotensin II; D001127:Arginine Vasopressin; D000431:Ethanol; D009638:Norepinephrine; D004837:Epinephrine