Effect of seasonal variation on lipid peroxide level and glutathione peroxidase activity in the mouse before and after adriamycin administration.
We examined the effect of seasonal variation on lipid peroxide levels and glutathione peroxidase (GSHpx) activity in tissues of normal and adriamycin (ADR)-treated mice. In the heart, normal lipid peroxide levels and GSHpx activity in November, December and January were lower than in other months. For the same period, lipid peroxide levels were higher and GSHpx activity lower in mice hearts after ADR administration. The results of GSHpx activity support those of lipid peroxide levels. We conclude that ADR-induced cardiotoxicity, related to the rise in level of lipid peroxide in mice hearts, is more likely to occur in winter than in other seasons.
Sadzuka
Y
Y
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Takino
Y
Y
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006321:Heart / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D012621:Seasons
D008054:Lipid Peroxides; D004317:Doxorubicin; D005979:Glutathione Peroxidase