[A cellular quantitative immune deficiency in chronic post-traumatic osteomyelitis].
The specific cellular host defence in patients with chronic post-traumatic bone infection was analyzed in a prospective study. The study included 120 patients with chronic post-traumatic osteomyelitis and 60 healthy volunteers. The number of CD-5, CD-4, CD-8, natural killer cells and the CD-4/CD-8 ratio were significantly decreased. The immunodeficiency seems to be trauma-induced and reinflammation seems to be due to other immunodeficient factors. The potential key role of a defect in cytokines is discussed.
Sistermann
R
R
Chirurgische Universitätsklinik und Poliklinik, Berufsgenossenschaftliche Krankenanstalten Bergmannsheil, Bochum.
Möllenhoff
G
G
Walz
M
M
Josten
C
C
Muhr
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D016130:Immunophenotyping; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
Eine zellulär quantitative Immundefizienz bei der chronisch posttraumatischen Osteomyelitis.