Aberrations of chromosome 19. Do they characterize a subtype of benign thyroid adenomas?
We describe the cytogenetic findings in two benign thyroid hyperplasias with aberrations of chromosome 19. In the first patient, two of four nodules showed identical translocations involving chromosome 19 and 22: 46,XX,der(19)t(19;?)(q13;?),der(22)t(22;?)(q12;?), the remaining nodules had an apparently normal karyotype. Two nodules from a second patient were karyotyped. One showed a karyotype 46,XX,t(1;19)(p35-36.1;q13) and the other had a normal karyotype. From these results as well as those reported previously, we can conclude that structural changes of chromosome 19 characterize a subgroup of thyroid adenomas, thyroid hyperplasias, or both.
Belge
G
G
Center of Human Genetics and Genetic Counselling, University of Bremen, Germany.
Thode
B
B
Bullerdiek
J
J
Bartnitzke
S
S
D000236:Adenoma / Q000235:genetics*; D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D007621:Karyotyping; D013964:Thyroid Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic