title: Immunomodulatory effect of interferon-alpha 2b on natural killer cells and T lymphocytes from patients with transitional cell carcinoma of the bladder.
abstract: Incubation of peripheral blood mononuclear cells (PBMNC) from patients with transitional cell carcinoma of the bladder, with interferon (IFN-alpha 2b) causes dose-dependent enhancement of natural killer (NK) and cytotoxic activity. Increased lytic activity was also observed against both NK-sensitive and NK-resistant target cells and T lymphocytes from such patients showed altered activity upon incubation with IFN-alpha 2b. Furthermore, intracavitary instillation of IFN-alpha 2b is associated with infiltration of the bladder wall by NK cells and T lymphocytes. Future work will be aimed at investigating the possible prognostic value of these results as related to the therapeutic effect of intracavitary instillation of IFN-alpha 2b.
authors.affiliation: Department of Medicine, Hospital Universitario Principe de Asturias, Universidad de Alcalá de Henares, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Alvarez-Mon
authors.forename: L M
authors.initials: LM
authors.lastname: Moltó
authors.forename: L
authors.initials: L
authors.lastname: Manzano
authors.forename: C
authors.initials: C
authors.lastname: Olivier
authors.forename: J A
authors.initials: JA
authors.lastname: Carballido
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000276:immunology* / Q000628:therapy; D006801:Humans; D016898:Interferon-alpha / Q000502:physiology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000502:physiology*; D013601:T-Lymphocytes / Q000502:physiology*; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000628:therapy
chemical_list: D016898:Interferon-alpha