The postantibiotic suppressive effect of L-ofloxacin, an optically active isomer of ofloxacin.
The postantibiotic suppressive effect (PAE) of L-ofloxacin was studied and compared with those of ciprofloxacin and norfloxacin. The PAE of L-ofloxacin was observed against all Gram-positive organisms tested: Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis. At the achievable serum concentrations L-ofloxacin showed a longer PAE than ciprofloxacin and norfloxacin. Exposure of organisms to 4 micrograms/ml of L-ofloxacin for 2 hr produced a 3.1 and 4.2 hr PAE for methicillin-sensitive and methicillin-resistant staphylococci, respectively. Against E. faecalis and S. epidermidis, the PAEs of L-ofloxacin were 1.9 and 1.6 hr, respectively.
Fu
K P
KP
Microbiology Research, R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869.
Foleno
B
B
Rosenthale
M E
ME
D002939:Ciprofloxacin / Q000494:pharmacology; D013293:Enterococcus faecalis / Q000254:growth & development; D006095:Gram-Positive Cocci / Q000187:drug effects* / Q000254:growth & development*; D009643:Norfloxacin / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000254:growth & development; D013237:Stereoisomerism
D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin