title: [Viral hepatitis A and the possible pathogenetic mechanisms of a protracted convalescence].
abstract: Metabolites of connective tissue (free serum oxyproline, protein-bound plasma oxyproline, total urine oxyproline, serum glycosaminoglycans), proteolytic enzyme elastase, proteolysis inhibitors (alpha 1-inhibitor, alpha 2-macroglobulin) were investigated in 103 patients with viral hepatitis A. It was established that connective tissue and its metabolites produce a negative effect on hepatocytic repair. Longterm convalescence is attributed to elastase hyperactivity in the presence of relative deficiency of proteolytic inhibitors.
authors.forename: K S
authors.initials: KS
authors.lastname: Ivanov
authors.forename: B F
authors.initials: BF
authors.lastname: Murashov
authors.forename: V M
authors.initials: VM
authors.lastname: Kapustin
mesh_terms: D000293:Adolescent; D000328:Adult; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism; D003289:Convalescence; D006025:Glycosaminoglycans / Q000097:blood; D006506:Hepatitis A / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D008115:Liver Regeneration / Q000502:physiology; D008297:Male; D010196:Pancreatic Elastase / Q000097:blood
chemical_list: D006025:Glycosaminoglycans; D003094:Collagen; D010196:Pancreatic Elastase
vernacular_title: Virusnyĭ gepatit A i vozmozhnye patogeneticheskie mekhanizmy zatianuvsheĭsia rekonvalestsentsii.