title: Plasmid mediated multidrug resistance in Salmonella typhi.
abstract: Between September 1989 and February 1991, strains of S. typhi showing multiple drug resistance were isolated from blood cultures of patients with typhoid fever. A total of 283 isolates were obtained over a period of 18 months. Forty four (11%) of these isolates were resistant to chloramphenicol, ampicillin, co-trimoxazole and tetracycline, the first three being drugs currently used in treating typhoid fever. Forty of the 44 multi-resistant strains tested showed transfer of resistance 'en block' to recipient Escherichia coli K 12 (J62-2). All 44 multi-resistant strains were sensitive to ciprofloxacin and ofloxacin. Since the resistance is plasmid-mediated, the problem is likely to get aggravated.
authors.affiliation: Department of Microbiology, Christian Medical College Hospital, Vellore.
authors.forename: M V
authors.initials: MV
authors.lastname: Jesudason
authors.forename: T J
authors.initials: TJ
authors.lastname: John
mesh_terms: D000668:Ampicillin Resistance / Q000235:genetics; D002702:Chloramphenicol Resistance / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D011815:R Factors; D012485:Salmonella typhi / Q000187:drug effects* / Q000235:genetics; D013753:Tetracycline Resistance / Q000235:genetics; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D014435:Typhoid Fever / Q000382:microbiology*
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination