Antioxidant-influenced alterations in glutathione reductase activity in different age groups of male mice.
The glutathione reductase activity was estimated in brain and liver of male mice of different age groups fed on butylated hydroxy anisole (BHA), propyl gallate (PG) and alpha-tocopherol (TP). A significant increase in glutathione reductase activity was observed with TP during all the phases (pre-reproductive, reproductive and post-reproductive). Antioxidants enhanced the enzyme activity in both the tissues with the exception of BHA in brain during reproductive and PG in liver during pre-reproductive phases respectively. The enhanced reducing potential of the cell in terms of added bioconversion of GSSG to GSH may account for increase in longevity on antioxidant treatment.
Khanna
S C
SC
Department of Molecular Biology, Guru Nanak Dev University, Amritsar, India.
Garg
S K
SK
Sharma
S P
SP
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D005980:Glutathione Reductase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D011435:Propyl Gallate / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D002083:Butylated Hydroxyanisole; D011435:Propyl Gallate; D005980:Glutathione Reductase