title: Two cases of acute myeloid leukemia evolving into a chronic myelomonocytic leukemia-like state after induction therapy.
abstract: Two patients with acute myeloid leukemia (AML) developed a chronic myelomonocytic leukemia (CMMoL)-like state after chemotherapy. Both patients showed morphological evidence of myelodysplasia together with acute leukemia at presentation (Case 1: M5b with trilineage myelodysplasia and Case 2: M4 with dysmegakaryocytopoiesis). They also showed persistent monocytosis without prominent blast cell proliferation after induction therapy. The possibility was suggested that these two patients were in acute transformation from CMMoL at presentation and returned to a CMMoL-like state after induction therapy.
authors.affiliation: Department of Medicine, Jichi Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iwama
authors.forename: A
authors.initials: A
authors.lastname: Miwa
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Suda
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Miura
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000209:etiology / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents