title: Innate immunity to a facultative intracellular bacterial pathogen.
abstract: The murine response to Listeria monocytogenes has long been considered a paradigm of T-cell-mediated immunity. There is, however, substantial evidence that T-cell-deficient mice are capable of surviving a L. monocytogenes challenge. Recently, advances have been made in our understanding of the cell biology and pathogenesis of infection.
authors.affiliation: University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: D A
authors.initials: DA
authors.lastname: Portnoy
mesh_terms: D000818:Animals; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology; D008089:Listeria monocytogenes / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D008088:Listeriosis / Q000276:immunology*; D008099:Liver / Q000382:microbiology; D008264:Macrophages / Q000276:immunology; D051379:Mice / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014774:Virulence
chemical_list: D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma