title: Effects of epidural and spinal anesthesia on blood rheology.
abstract: This study was designed to compare the influence of epidural and spinal anesthesia on blood viscosity. We studied 22 patients, ASA classification I, who underwent elective knee or ankle arthroscopy and received epidural (n = 11) or spinal (n = 11) anesthesia with plain bupivacaine, and 10 control volunteers, who did not undergo surgery or receive anesthesia. There were significant decreases in hematocrit, plasma viscosity, and whole-blood viscosity at high (70 s-1), medium (0.5 s-1), and low (0.05 s-1) shear rates. The magnitude of changes was similar in all groups but occurred earlier in the control group (between 10 and 30 min) and after spinal administration (between 10 and 30 min) rather than after epidural administration (between 30 and 60 min) of bupivacaine. Only spinal anesthesia was associated with a decrease in erythrocyte deformability. The observed rheologic changes are attributed to hemodilution from the intravenous administration of fluids and the redistribution of fluid in the intravascular and extravascular compartments after sympathetic blockade and to postural changes rather than the effect of bupivacaine on blood elements.
authors.affiliation: Department of Anaesthesiology, University of Amsterdam, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Odoom
authors.forename: J G
authors.initials: JG
authors.lastname: Bovill
authors.forename: M R
authors.initials: MR
authors.lastname: Hardeman
authors.forename: J
authors.initials: J
authors.lastname: Oosting
authors.forename: W W
authors.initials: WW
authors.lastname: Zuurmond
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000775:Anesthesia, Spinal; D000843:Ankle Joint / Q000601:surgery; D001182:Arthroscopy; D001809:Blood Viscosity / Q000187:drug effects*; D002045:Bupivacaine; D005260:Female; D006400:Hematocrit; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002045:Bupivacaine