Developmental expression of S-antigen in fetal human and rat eye.
Development expression of S-antigen and its mRNA in human and rat fetal retina was studied by immunocytochemical and in situ hybridization techniques. Immunocytochemistry indicated that S-antigen was present after 4 months gestation in the fetal human retina. In the rat, S-antigen was detected in the retina only after birth. In situ hybridization studies indicated that the S-antigen mRNA was present at 13 weeks gestational age in the human and at 15 days in the rat embryo. S-antigen mRNA was expressed not only in the retina but also in ocular tissues of neural crest origin in the fetus.
Ni
M
M
Laboratory of Retinal Cells and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.
Yamaki
K
K
Kikuchi
T
T
Ferrick
M
M
Shinohara
T
T
Nussenblatt
R B
RB
Chan
C C
CC
D000328:Adult; D000818:Animals; D000831:Animals, Newborn; D000941:Antigens / Q000032:analysis* / Q000235:genetics; D019393:Arrestin; D005314:Embryonic and Fetal Development / Q000276:immunology*; D005136:Eye Proteins / Q000032:analysis* / Q000235:genetics; D005865:Gestational Age; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008565:Membrane Proteins / Q000032:analysis*; D009693:Nucleic Acid Hybridization; D015347:RNA Probes; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000196:embryology / Q000276:immunology*
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D008565:Membrane Proteins; D015347:RNA Probes; D012333:RNA, Messenger