Effect of elastin peptides on the activities of antioxidant enzymes in fibroblasts.
The effect of elastin peptides (kappa-elastin) was investigated on murine fibroblasts. The data indicate that elastin peptides increase the activities of antioxidant enzymes detoxifying free radicals and increase the lipid peroxide concentration within the cell. These results suggest that the influence of elastin peptides on oxygen metabolism may be related to their activities in vivo following elastin degradation and can contribute to their role in the pathogenesis of atherosclerosis.
Weglarz
L
L
Department of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
Gmiński
J
J
Drózdz
M
M
Goss
M
M
D000818:Animals; D002374:Catalase / Q000032:analysis; D002478:Cells, Cultured; D004549:Elastin / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000032:analysis; D008054:Lipid Peroxides / Q000032:analysis*; D051379:Mice; D010088:Oxidoreductases / Q000032:analysis*; D010446:Peptide Fragments / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000032:analysis
D008054:Lipid Peroxides; D010446:Peptide Fragments; D004549:Elastin; D010088:Oxidoreductases; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase