[Biochemical mechanisms of neurotoxic reactions to antibacterial preparations in patients with pulmonary tuberculosis].
Examination comprising the electrophysiologic method and study of the biochemical parameters of the antioxidant/lipid peroxidation system and metabolism of biologic amines in 163 patients with infiltrative pulmonary tuberculosis has revealed a clear interaction existing between the functional changes of the CNS state, the state of antioxidative defense (alpha-tocopherol) and serotonin. This allows an assumption that the antioxidant/lipid peroxidation system and serotoninergic system actively participate in the pathogenesis of development of neurotoxic reactions to antibacterial preparations in the clinical picture of tuberculosis.
Chelnokova
N V
NV
Starostenko
E V
EV
Salpagarov
A M
AM
Smirnova
N A
NA
Kruglova
E G
EG
D000975:Antioxidants / Q000378:metabolism; D000995:Antitubercular Agents / Q000633:toxicity*; D001669:Biochemical Phenomena; D001671:Biochemistry; D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography; D006801:Humans; D015227:Lipid Peroxidation; D012701:Serotonin / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000378:metabolism; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D000995:Antitubercular Agents; D014810:Vitamin E; D012701:Serotonin
Biokhimicheskie mekhanizmy neĭrotoksicheskikh reaktsiĭ na antibakterial'nye preparaty u bol'nykh tuberkulezom legkikh.