title: [The gastric mucosal adhesiveness of Z-103 in rats with chronic ulcer].
abstract: The gastric mucosal adhesiveness of Z-103 in rats with acetic acid ulcer was studied macroscopically, histologically, and biochemically. From macroscopical observations, when Z-103 was orally administered to an acetic acid ulcer model, there was adhesion of Zn to the normal mucosa as well as the ulcerous site under both the fasting condition and after feeding. It was also proven that the strength and duration of adhesiveness were increased dose-dependently under fasting conditions. In addition, histological localization of Zn was noted from the covering epithelial cell layer to the gastric lamina propria mucosae in the normal tissue and in the most superficial ulcerous layer and the granulous layer of the ulcerous site. Measurement of the gastric tissue Zn content after oral administration of 100 mg/kg of Zn showed that the Zn content was significantly increased for 6 hr at the normal site and for 24 hr at the ulcerous site. On the other hand, although ZnSO4 and ZnSO4+carnosine combination macroscopically produced generally the same level of adhesiveness as Z-103, when the gastric tissue Zn content for Z-103 and ZnSO4 were compared, the Zn content of ZnSO4 was lower than that for Z-103 at both the normal and ulcerous site. In summary, Z-103 shows a long-term adhesive and permeable action on the gastric mucosa in acetic acid ulcer rats, and it has a comparable high affinity at the ulcerous site.
authors.affiliation: Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Saitama, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Seiki
authors.forename: H
authors.initials: H
authors.lastname: Aita
authors.forename: Y
authors.initials: Y
authors.lastname: Mera
authors.forename: K
authors.initials: K
authors.lastname: Arai
authors.forename: S
authors.initials: S
authors.lastname: Toyama
authors.forename: S
authors.initials: S
authors.lastname: Furuta
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Yoneta
authors.forename: E
authors.initials: E
authors.lastname: Tagashira
mesh_terms: D000085:Acetates; D019342:Acetic Acid; D000268:Adhesiveness; D000818:Animals; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics*; D002336:Carnosine / Q000031:analogs & derivatives*; D002908:Chronic Disease; D004151:Dipeptides / Q000493:pharmacokinetics*; D005215:Fasting / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D008297:Male; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism*; D015032:Zinc / Q000493:pharmacokinetics; D017967:Zinc Compounds
chemical_list: D000085:Acetates; D000897:Anti-Ulcer Agents; D004151:Dipeptides; D009942:Organometallic Compounds; D017967:Zinc Compounds; C061957:polaprezinc; D002336:Carnosine; D015032:Zinc; D019342:Acetic Acid