The influence of detergents on skin barrier properties.
The influence of surfactants on the changes in skin barrier properties was investigated in rats. Various ionic and non-ionic surfactants were assessed using indomethacin as a model penetrant. The surfactants appeared to either increase or decrease the skin permeability, due to the properties of both compound and surfactant. Ionic surfactant sodium dodecylsulfate was the most powerful and exceeded controls by approximately 10 times measured by means of serum levels of indomethacin. Other surfactants caused concentration increase or decrease of indomethacin in serum.
Príborský
J
J
Department of Pharmaceutics, Hoshi University, Tokyo, Japan.
Takayama
K
K
Príborská
Z
Z
Mühlbachová
E
E
Nagai
T
T
D000279:Administration, Cutaneous; D000818:Animals; D003902:Detergents / Q000008:administration & dosage / Q000494:pharmacology*; D005782:Gels; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption / Q000187:drug effects*
D003902:Detergents; D005782:Gels; D007213:Indomethacin