title: [Proteinase-inhibitors and renin in the pathogenesis of vascular insufficiency in acute pneumonia].
abstract: The system proteinases-inhibitors and renin were studied in 105 acute pneumonia (AP) patients, the blood of whom was examined for concentrations of elastase, acid proteases (AP), alpha 1-inhibitor of proteases (alpha 1-IP), alpha 2-macroglobulin (alpha 2-MG) and active or inactive, total renin (TR). A separate group included 18 AP cases complicated by infective toxic shock (ITS). An imbalance was proved in the system proteinases-inhibitors with dominance of the inhibitory potential. In a "cold" variant of ITS proteolytic blood activity rose while the inhibitory capacity fell. Moderate and severe AP forms were associated with lowered blood levels of active R and elevated of inactive R, TR. In arterial hypotonia and ITS these changes were most demonstrable. Elastase, alpha 1-IP, alpha 2-MG and active R, inactive R, TR exhibited close correlation. The discussion covered mechanisms of hemodynamic disturbances in AP with consideration of depressed renin-angiotensin system and imbalance of proteinases and their inhibitors.
authors.forename: B I
authors.initials: BI
authors.lastname: Gel'tser
authors.forename: A V
authors.initials: AV
authors.lastname: Koriakov
authors.forename: G V
authors.initials: GV
authors.lastname: Butovets
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D010450:Endopeptidases / Q000097:blood*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D011014:Pneumonia / Q000201:enzymology / Q000209:etiology* / Q000503:physiopathology; D011480:Protease Inhibitors / Q000097:blood*; D012083:Renin / Q000097:blood*; D012772:Shock, Septic / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology
chemical_list: D011480:Protease Inhibitors; D010450:Endopeptidases; D012083:Renin
vernacular_title: Proteinazy--ingibitory i renin v patogeneze sosudistoĭ nedostatochnosti pri ostroĭ pnevmonii.