title: CD1 (OKT6)-positive juvenile xanthogranuloma. OKT6 is not specific for Langerhans cell histiocytosis (histiocytosis X).
abstract: A 16-month-old boy had multiple papules on the face and trunk that were clinically and histologically typical of juvenile xanthogranulomas. Cells from the lesions reacted to staining for OKT6, but Birbeck granules were not identified ultrastructurally, which suggests that OKT6 is not a specific marker for Langerhans cell lineage.
authors.affiliation: Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY.
authors.forename: W K
authors.initials: WK
authors.lastname: Andersen
authors.forename: D M
authors.initials: DM
authors.lastname: Knowles
authors.forename: D N
authors.initials: DN
authors.lastname: Silvers
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis* / Q000276:immunology; D001666:Binding Sites, Antibody / Q000276:immunology; D003937:Diagnosis, Differential; D006644:Histiocytes / Q000276:immunology* / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007223:Infant; D007801:Langerhans Cells / Q000276:immunology* / Q000473:pathology; D008297:Male; D051379:Mice; D014972:Xanthogranuloma, Juvenile / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD