title: Giant basal prolactinoma extending into the nasal cavity.
abstract: An unusual case of a giant prolactinoma extending to the nasopharynx and nasal cavity is presented. A 35-year-old man admitted for nasal obstruction and visual disturbances was found to have bilateral anosmia, right homonymous hemianopsia, and a right hemiparesis. The serum prolactin level was 13,300 ng/mL. Radiological examination revealed a large mass invading the skull base and extending into the suprasellar region and the left frontal lobe superiorly and into the nasopharynx inferiorly. Subtotal removal was done through a bilateral orbitofrontal craniotomy, which was followed by radiotherapy and bromocriptine administration. Immunohistochemical analysis confirmed a prolactinoma. The rarity of such a tumor, its location and extension, and the usefulness of magnetic resonance imaging and immunohistochemistry are stressed. Pertinent literature is reviewed.
authors.affiliation: Department of Neurosurgery, Osaka City University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwai
authors.forename: A
authors.initials: A
authors.lastname: Hakuba
authors.forename: V K
authors.initials: VK
authors.lastname: Khosla
authors.forename: M
authors.initials: M
authors.lastname: Nishikawa
authors.forename: J
authors.initials: J
authors.lastname: Katsuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D015175:Prolactinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography