title: Carcinoma of the nasopharynx: analysis of treatment results in 167 consecutively admitted patients.
abstract: Radiotherapy with curative intent was administered to 159 of 167 consecutively admitted patients with nasopharyngeal carcinoma. The classification (UICC 1982) gave the staging: stage I 8%, stage II 2%, stage III 28%, and stage IV 61%. The actuarial local tumor control was 54% and correlated to the T-classification. Primary control of neck nodes was 67% but was not correlated to the N-classes. Distant failure occurred in 20% of the patients; this was correlated to the N-classification. The 10-year actuarially corrected survival rate was 37% (stage I+II 60%, stage III 49%, stage IV 27%). Late reactions were seen in 69%, and most patients had mild to moderate xerostomia. Men with high hemoglobin had a better prognosis than men with values in the lower part of the normal range. It is concluded that primary control in the T- and N-positions is the parameter most crucial to success.
authors.affiliation: Department of Oncology and Radiotherapy, Danish Cancer Society, Aarhus, Denmark.
authors.forename: L V
authors.initials: LV
authors.lastname: Johansen
authors.forename: M
authors.initials: M
authors.lastname: Mestre
authors.forename: J
authors.initials: J
authors.lastname: Overgaard
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000009:adverse effects; D015996:Survival Rate; D016896:Treatment Outcome