title: Lactate mapping in ischemic rat kidneys using 1H spectroscopic imaging.
abstract: OBJECTIVE
  Biochemical studies have shown that during renal ischemia, lactate is built up predominantly in the medulla and less in the cortex. The authors intend to confirm such a difference in lactate concentration between these two zones of the kidney by means 1H magnetic resonance (MR) spectroscopy.
  
  
  METHODS
  In 10 rats, the authors used four-dimensional (n = 4) and three-dimensional (n = 6) spectroscopic imaging to investigate the left kidney after occlusion of the renal artery.
  
  
  RESULTS
  By this technique, a map of the intrarenal lactate distribution was obtained during ischemia. It was determined that lactate concentration is indeed higher in the medulla than in the cortex, as verified by chemical analysis (17 +/- 4 versus 9 +/- 4 mumol/g).
  
  
  CONCLUSIONS
  By correlating biochemical and morphologic information, localized MR spectroscopy combined with imaging is a powerful tool for investigating pathophysiologic mechanisms.
authors.affiliation: Institute of Diagnostic Radiology, University of Berne, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Terrier
authors.forename: F
authors.initials: F
authors.lastname: Lazeyras
authors.forename: B M
authors.initials: BM
authors.lastname: Frey
authors.forename: F J
authors.initials: FJ
authors.lastname: Frey
mesh_terms: D000818:Animals; D005260:Female; D007091:Image Processing, Computer-Assisted; D007511:Ischemia / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply*; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D007773:Lactates / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007773:Lactates