title: Long term success of aortoiliac operation for arteriosclerotic obstructive disease.
abstract: The current retrospective study was performed on 747 patients with aortoiliac obstructive disease who underwent reconstructive operation. Unlike many other centers, the University Hospital Leiden has, throughout the years, maintained the strategy of avoiding the implantation of a prosthesis in patients with limited and localized obstructive disease that could readily be treated with an endarterectomy. When a prosthesis was used, it was anastomosed to the femoral artery if a more proximal anastomosis was not feasible. In the present study, the long term outcome of the strategy is evaluated. Three groups of patients were studied--245 patients with moderate claudication, 331 patients with severe claudication and 162 patients with critical ischemia at presentation. Thromboendarterectomies were used in 229 patients (30.7 per cent) and prosthetic reconstructions in 518 patients (69.3 per cent), of which 339 (45.5 per cent) were aortoiliac reconstructions. The perioperative mortality rates were 1.6, 3.0 and 3.1 per cent for the three groups, respectively. Atherosclerotic heart disease was the most common cause of perioperative (30.0 per cent) and late (30.8 per cent) death. Late complications of surgical treatment also contributed significantly to the causes of late deaths (12.1 per cent). Because over-all survival rates in the current series compared favorably with those in other series, the influence of reconstructive operation on late survival was compensated for by a beneficial effect in patients without such complications. Secondary operations for late complications, such as false aneurysms and aortoiliac reobstruction or for progressive obstructive disease, were necessary in 21 per cent of all 727 survivors of the first operation. Actuarial curves with various endpoints--mortality, secondary operation, patency of aortoiliac segments, functional failure, amputation, presence of mild, moderate and severe claudication--were calculated according to the standard method of life table construction. In terms of technical success rates, the results of our surgical technique strategy compared favorably with those reported in other series, in which most patients were treated with aortobifemoral prostheses. The chances of functional failure increased with time, amounting to about 23 per cent at 15 years postoperatively for each group of patients. Comparison of technical and functional success rates showed a significant disparity, which was explained by the effects of collateral blood flow in instances of aortoiliac reobstruction and of progressing femoropopliteal obstructions in instances of open aortoiliac vessels.
authors.affiliation: Department of Surgery, University Hospital Leiden, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van den Akker
authors.forename: R
authors.initials: R
authors.lastname: van Schilfgaarde
authors.forename: R
authors.initials: R
authors.lastname: Brand
authors.forename: J H
authors.initials: JH
authors.lastname: van Bockel
authors.forename: J L
authors.initials: JL
authors.lastname: Terpstra
mesh_terms: D000206:Actuarial Analysis; D001012:Aorta, Abdominal / Q000601:surgery; D001018:Aortic Diseases / Q000401:mortality / Q000601:surgery*; D001161:Arteriosclerosis / Q000401:mortality / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D002423:Cause of Death; D004691:Endarterectomy; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000601:surgery*; D007383:Intermittent Claudication / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome