A new mathematical model to study bone turnover in growing rats.
A new mathematical model for the study of bone turnover in growing rats was developed. The model predicts a linear relationship between bone mineral content (BMC) and biochemical markers (BMK) of bone turnover assuming that rats are growing, bone turnover is profoundly affected by skeletal maturation, and resorption and formation are physiologically balanced. The model validation was performed by measuring galactosyl-hydroxylysine (GHYL) and hydroxyproline (HYP) in urines. This mathematical evidence supports our proposed use of the specific bone resorption marker GHYL to predict bone mineral content. Further studies on bone turnover will be possible by the application of the same approach.
Reina
G
G
Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milano, Italy.
Moro
L
L
Rubinacci
A
A
Bettica
P
P
Villani
P
P
Rovis
L
L
Moro
G L
GL
de Bernard
B
B
Pecile
A
A
D015502:Absorptiometry, Photon; D000375:Aging; D000818:Animals; D015415:Biomarkers; D015519:Bone Density / Q000502:physiology; D001846:Bone Development / Q000502:physiology*; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006901:Hydroxylysine / Q000031:analogs & derivatives / Q000378:metabolism; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains / Q000254:growth & development; D012727:Sex Characteristics
D015415:Biomarkers; D006901:Hydroxylysine; C007817:galactosylhydroxylysine; D006909:Hydroxyproline