Treatment resistance of depression after head injury: a preliminary study of amitriptyline response.
Thirteen patients with depression following minor head injury were matched with 13 functional depressives. Both groups were indistinguishable psychopathologically. Five of the functional group had a family history of affective disorder and none of the head-injury group had such a history. Both groups were treated with amitriptyline, beginning with 100 mg daily, increasing to a maximum of 250 mg/d. There were significant differences in response between the 2 groups, with only 4 of the head-injury patients improving. Our preliminary results suggest that this condition is relatively resistant to tricyclic therapy.
Dinan
T G
TG
Department of Psychiatry, Trinity College Medical School, Dublin, Ireland.
Mobayed
M
M
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D001925:Brain Damage, Chronic / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016489:Head Injuries, Closed / Q000150:complications* / Q000523:psychology; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000523:psychology; D010555:Personality Inventory
D000639:Amitriptyline