[AgNOR in neurooncology].
By means of a standardized silver staining technique, nucleolar organizer region-associated proteins (AgNORs) have been demonstrated in paraffin sections of 41 astrocytomas and glioblastomas and 19 meningiomas. Computer-assisted image analysis was used to measure AgNORs together with other nuclear features. Significant differences in number and configuration of AgNORs have been found between non-anaplastic astrocytomas and anaplastic gliomata. In meningiomas, tumours with signs of increased proliferative activity and usual non-anaplastic ones could be discriminated using AgNOR data.
Martin
H
H
Institut für Pathologie, Humboldt-Universität, Charité.
Gottschalk
J
J
Hufnagl
P
P
Beil
M
M
D001254:Astrocytoma / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D005910:Glioma / Q000473:pathology; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology; D008579:Meningioma / Q000473:pathology; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D016612:Paraffin Embedding; D016622:Silver Staining
AgNORs in der Neuroonkologie.