Acquired amegakaryocytic thrombocytopaenia in a child.
A boy aged 5 years is described with amegakaryocytic thrombocytopaenia, which was associated with defective granulopoiesis and erythropoiesis, but did not evolve into marrow aplasia. Marrow cultures confirmed the presence of abnormalities in each of the haemopoietic lineages and identified defective maturation of megakaryocytic precursors. The was no evidence of a humoral inhibitor of megakaryopoiesis. The patient's blood cell counts responded to treatment with oxymetholone.
Scarlett
J D
JD
Department of Haematology, Geelong Hospital, Victoria, Australia.
Williams
N T
NT
McKellar
W J
WJ
D001853:Bone Marrow / Q000503:physiopathology; D002675:Child, Preschool; D006410:Hematopoiesis; D006801:Humans; D008297:Male; D008533:Megakaryocytes / Q000502:physiology*; D010110:Oxymetholone / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000097:blood* / Q000188:drug therapy / Q000209:etiology
D010110:Oxymetholone