title: Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.
abstract: Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) has a poor prognosis when treated with conventional chemotherapy. We analyzed the outcome of 67 HLA-identical sibling bone marrow transplants (BMTs) for Ph1-positive ALL reported to the International Bone Marrow Transplant Registry (IBMTR). Twenty-one of 67 (31%) transplant recipients survived in continuous complete remission more than 2 years after transplant. Two-year actuarial probabilities (95% confidence interval) of leukemia-free survival were 38% (23% to 55%) for 33 patients transplanted in first remission, 41% (23% to 61%) for 22 patients transplanted after relapse, and 25% (9% to 53%) for 12 patients failing to achieve remission with conventional chemotherapy. These data indicate that transplants are effective treatment for Ph1-positive ALL.
authors.affiliation: Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
authors.forename: A J
authors.initials: AJ
authors.lastname: Barrett
authors.forename: M M
authors.initials: MM
authors.lastname: Horowitz
authors.forename: R C
authors.initials: RC
authors.lastname: Ash
authors.forename: K
authors.initials: K
authors.lastname: Atkinson
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
authors.forename: J M
authors.initials: JM
authors.lastname: Goldman
authors.forename: P J
authors.initials: PJ
authors.lastname: Henslee-Downey
authors.forename: R H
authors.initials: RH
authors.lastname: Herzig
authors.forename: B
authors.initials: B
authors.lastname: Speck
authors.forename: F E
authors.initials: FE
authors.lastname: Zwaan
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D006086:Graft vs Host Disease; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000601:surgery*; D012074:Remission Induction