Use of transgenic mice in the study of proto-oncogene functions.
The introduction of genes into the germ line of mammals has been utilized to study the regulation of gene expression, the role of certain genes during development and to establish animal models of human diseases. The present report explores the application of transgenic mice methodology to the study of the normal and transforming activity of some proto-oncogenes in the living animal. The major findings of these studies and their contribution to our understanding of the role of these proto-oncogenes in development and transformation will be evaluated.
Eva
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Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892.
D000818:Animals; D015870:Gene Expression / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes / Q000502:physiology*; D011995:Recombination, Genetic / Q000502:physiology; D016211:Transforming Growth Factor alpha / Q000502:physiology
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016211:Transforming Growth Factor alpha