[The hexobarbital sleeping time in a pharmacologico-toxicological experiment with special reference to age and chronobiologically-limited variations in Wistar rat strain WIST/Lppt].
Investigations were performed to determine the hexobarbital sleeping time (HST) of a strain of Wistar rats (WIST/Lppt). Another aim of the studies was to demonstrate possibilities to use the HST as a method to get additional informations during pharmacological and toxicological experiments. The age--and sex--dependent changes in the hexobarbital sleeping time of the investigated strain of rats are in coincidence with results of other authors, using different rat strains. Additionally, the HST more or less depends on circadian and circannual rhythm. It was stated that the HST as a prescreening-method before starting investigations in detail is of great importance.
Lange
N
N
Institut für Pharmakologie, Pharmazie und Toxikologie der Veterinärmedizinischen Fakultät der Universität Leipzig.
Kühnert
M
M
Ebbinghaus
F
F
Hille
G
G
Wolf
U
U
D000367:Age Factors; D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D006591:Hexobarbital; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012621:Seasons; D012727:Sex Characteristics; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D006591:Hexobarbital
Untersuchungen zur Hexobarbitalschlafzeit im pharmakologisch-toxikologischen Experiment unter besonderer Berücksichtigung alters- und chronobiologisch bedingter Schwankungen bei Wistarratten Stamm WIST/Lppt.