title: Endurance training changes central and peripheral responses to physostigmine.
abstract: Whether the pharmacodynamics of physostigmine (Phy) [rate of decarbamylation of cholinesterase (ChE) enzyme] (Kd) is altered due to acute and/or trained exercise in brain and various tissues of rat has been addressed. Acute exercise (AE) + Phy increased, whereas endurance training (ET) + Phy decreased ChE activity in brain, red blood cells (RBC), and various tissues as compared to Phy alone. The Kd of brain ChE was significantly increased (181% of control) by AE + Phy and decreased (66% of control) by ET + Phy as compared to Phy alone. There was a slight increase (114% of control) in Kd of RBC-ChE in AE + Phy as compared to Phy alone. The Kd of heart ChE was significantly decreased (44% of control) by ET + Phy as compared to Phy alone. The Kd of diaphragm ChE was significantly increased (384% of control) in AE + Phy and decreased (80% of control) in ET + Phy as compared to Phy alone. The Kd of muscle ChE significantly decreased (67% of control) by AE + Phy as compared to Phy alone, but ET + Phy did not affect the Kd in muscle. These results suggested that AE and ET have opposite effects on Kd after Phy administration.
authors.affiliation: Department of Pharmacology, Southern Illinois University, School of Medicine, Springfield 62794-9230.
authors.forename: S M
authors.initials: SM
authors.lastname: Somani
authors.forename: S N
authors.initials: SN
authors.lastname: Dube
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D002802:Cholinesterases / Q000032:analysis*; D003964:Diaphragm / Q000201:enzymology; D008297:Male; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D010807:Physical Endurance / Q000502:physiology*; D010830:Physostigmine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010830:Physostigmine; D002802:Cholinesterases