Hyperthyroidism accelerates growth in Turner's syndrome.
Graves' disease in a girl with Turner's syndrome (karyotype 46,Xdel(Xp)) is described. Hyperthyroidism led to a pronounced acceleration of height velocity. During treatment with methimazole and L-thyroxine, height velocity normalized. The patient also developed spontaneous puberty with a clear-cut pubertal growth spurt. Final height, however, did not appear to be influenced either by Graves' disease or by spontaneous puberty.
Massa
G
G
Department of Paediatrics, University of Leuven, Belgium.
de Zegher
F
F
Dooms
L
L
Vanderschueren-Lodeweyckx
M
M
D002648:Child; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006130:Growth Disorders / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008713:Methimazole / Q000008:administration & dosage / Q000627:therapeutic use; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use; D011627:Puberty; D013960:Thyroid Function Tests; D013974:Thyroxine / Q000008:administration & dosage / Q000627:therapeutic use; D014424:Turner Syndrome / Q000150:complications* / Q000175:diagnosis
D008713:Methimazole; D011433:Propranolol; D013974:Thyroxine