[Evaluation of the effects of reduced glutathione in subjects with acquired and congenital changes in heme biosynthesis].
In order to evaluate the possible therapeutical effects of reduced glutathione in subjects affected by acquired or congenital heme biosynthesis alterations, two groups of subjects have been considered: the first, of 5 subjects with abnormal lead absorption, the second of 10 patients suffering from porphyria cutanea tarda (PCT). The drug was administered i.v. at the dosage of 600-1200 mg for a variable period of 3-5 days in the first group, for 7-10 days in the patients with PCT. In the lead-exposed subjects an increase in the activity of ALA-dehydratases enzyme was observed, with a decrease in the urinary excretion of delta-aminolevulinic acid, and a decrease in the percentage of urinary coproporphyrins as well. In the patients with PCT, after the therapy, a relevant reduction of urinary excretion of porphyrins, prevalently uro- and heptaporphyrins, was noticed. The results of this preliminary study suggest that glutathione can exert an effect of "normalization" on heme biosynthesis when altered in acquired and/or congenital conditions.
Ferioli
A
A
Università degli Studi di Brescia, Cattedra e Servizio di Medicina del Lavoro, Boehringer Mannheim Italia S.p.a., Milano.
De Vincentiis
A
A
Buizza
P
P
Pasolini
G
G
Leali
C
C
De Panfilis
G
G
Alessio
L
L
D000622:Aminolevulinic Acid / Q000652:urine; D003306:Coproporphyrins / Q000652:urine; D005978:Glutathione / Q000008:administration & dosage / Q000627:therapeutic use*; D006418:Heme / Q000096:biosynthesis*; D006801:Humans; D007855:Lead Poisoning / Q000188:drug therapy* / Q000378:metabolism; D011164:Porphyrias / Q000188:drug therapy* / Q000378:metabolism; D011166:Porphyrins / Q000652:urine; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors; D014578:Uroporphyrins / Q000652:urine
D003306:Coproporphyrins; D011166:Porphyrins; D014578:Uroporphyrins; D006418:Heme; D000622:Aminolevulinic Acid; D005978:Glutathione
Valutazione degli effetti del glutatione ridotto in soggetti con alterazioni acquisite e congenite della biosintesi dell'eme.