Effects of calcium antagonists on the cocaine- and methamphetamine-induced conditioned place preference.
The effects of calcium antagonists (nifedipine, flunaridine and diltiazem) on the cocaine- and methamphetamine-induced place preference were examined. Calcium antagonists alone induced neither place preference nor place aversion. Nifedipine markedly antagonized and flunarizine and diltiazem reduced the cocaine-induced place preference. The methamphetamine-induced place preference was reduced by nifedipine and diltiazem, but not by flunarizine. These results suggest the possibility that the cocaine-induced place preference is strongly influenced by dihydropyridine sensitive calcium channels, whereas the methamphetamine-induced place preference is not.
Suzuki
T
T
Department of Applied Pharmacology, School of Pharmacy, Hoshi University.
Shiozaki
Y
Y
Masukawa
Y
Y
Misawa
M
M
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003042:Cocaine / Q000037:antagonists & inhibitors*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004110:Diltiazem / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005444:Flunarizine / Q000494:pharmacology; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D002121:Calcium Channel Blockers; D008694:Methamphetamine; D004110:Diltiazem; D003042:Cocaine; D009543:Nifedipine; D005444:Flunarizine