Anomalous effect of mazindol on dopamine uptake as measured by in vivo voltammetry and microdialysis.
The effect of mazindol on the dopamine (DA) uptake system in the rat striatum was studied by in vivo voltammetry and microdialysis. An increase in the maximal uptake rate was observed by voltammetry 30 min after i.p. administration of 1, 5, 10, 15, and 20 mg/kg doses but not after a dose of 25 mg/kg, while stimulated release was enhanced at all doses. The increased maximal uptake is in contrast to increased levels of extracellular DA observed with microdialysis following mazindol administration. This divergence of action is anomalous in the context of current understanding of the DA uptake system.
Ng
J P
JP
Department of Chemistry, Emory University, Atlanta, GA 30322.
Menacherry
S D
SD
Liem
B J
BJ
Anderson
D
D
Singer
M
M
Justice
J B
JB
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003956:Dialysis / Q000379:methods; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004563:Electrochemistry / Q000379:methods; D007700:Kinetics; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D008454:Mazindol; D004298:Dopamine