Vascular manifestations in homocystinuria.
Homocystinuria was discovered in a 21-year-old woman when she presented with lower limb ischemia and pulmonary embolism. This patient had a partial deficit in cystathionine-synthetase and took strongly dosed oral contraceptive medication. This report underscores: (1) the value of searching for this type of pathology even in the adult; (2) the possibility of disclosure by another condition, and particularly, drug-induced; (3) the importance of searching for other involved members of the same family; and (4) the possibility of treatment in vitamin sensitive patients.
Favre
J P
JP
Service de Chirurgie Cardio-Vasculaire, et d'Angiologie, Centre Hospitalier et Universitaire de Dijon, France.
Becker
F
F
Lorcerie
B
B
Dumas
R
R
David
M
M
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D005260:Female; D006712:Homocystinuria / Q000150:complications*; D006801:Humans; D007083:Iliac Artery; D007084:Iliac Vein; D007511:Ischemia / Q000139:chemically induced / Q000209:etiology*; D007866:Leg / Q000098:blood supply*; D011655:Pulmonary Embolism / Q000209:etiology; D013927:Thrombosis / Q000209:etiology
D003277:Contraceptives, Oral, Combined