CSF chromogranin A-like immunoreactivity in schizophrenia: relationships with REM latency and slow wave sleep.
Chromogranin A (CgA) is a calcium binding protein and a precursor of modulatory peptides in the brain. We measured CgA-like immunoreactivity (CgA-LI) in cerebrospinal fluid (CSF) in 15 male schizophrenic patients (diagnosed by DSM-III-R criteria) after 3 nights of polysomnography. Patients had been drug free for at least 33 days. Our earlier report that CSF CgA-LI in schizophrenic patients correlated significantly with negative symptoms and ventricle-brain ratios, which have been related to slow wave sleep, raised the possibility that CgA-LI might relate to slow wave sleep. CSF CgA-LI was significantly correlated with stage 4 sleep and rapid eye movement latency. Whether these positive relationships between CSF CgA-LI and electroencephalographic sleep measures are specific for schizophrenia awaits further study.
van Kammen
D P
DP
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA.
O'Connor
D T
DT
Neylan
T C
TC
Mouton
A
A
Gurklis
J A
JA
Gilbertson
M W
MW
Peters
J L
JL
D000328:Adult; D053379:Chromogranin A; D002864:Chromogranins / Q000134:cerebrospinal fluid*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D011930:Reaction Time / Q000502:physiology*; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D012565:Schizophrenic Psychology; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins