title: Prevention of infection in burns: preliminary experience with selective decontamination of the digestive tract in patients with extensive injuries.
abstract: Evidence from studies of trauma patients suggests that selective decontamination of the digestive tract (SDD) might also be of value in preventing colonization and infection by enteric organisms in burn patients. In a retrospective study, 31 consecutive patients with burns of greater than 30% of total body surface area, admitted over a 2-year period, who were treated with an SDD regimen, were compared with a similar group of 33 consecutive patients admitted in the 2 years immediately preceding the introduction of SDD. Fewer SDD-treated patients developed wound colonization with Pseudomonas species (29% vs. 61%), or with Enterobacteriaceae (10% vs. 73%). Similar reductions in colonization with gram-negative organisms were found in urine and gastric aspirates. There were fewer respiratory infections in the SDD group (6.5% vs. 27.3%), and only one patient developed septicemia, compared with eight in the control group (3.2% vs. 24.2%). Fewer SDD-treated patients died (one death, compared with seven in the non-SDD group). These results suggest that SDD may be of value in the management of patients with severe burn injuries, but further studies are required to test the validity of this conclusion.
authors.affiliation: Burns Centre of the Red Cross Hospital, Beverwijk, The Netherlands.
authors.forename: D P
authors.initials: DP
authors.lastname: Mackie
authors.forename: W A
authors.initials: WA
authors.lastname: van Hertum
authors.forename: T
authors.initials: T
authors.lastname: Schumburg
authors.forename: E C
authors.initials: EC
authors.lastname: Kuijper
authors.forename: P
authors.initials: P
authors.lastname: Knape
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D001431:Bacteriological Techniques; D002056:Burns / Q000150:complications* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D004064:Digestive System / Q000382:microbiology*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018805:Sepsis / Q000517:prevention & control; D013242:Sterilization / Q000379:methods*; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents