Uracil-induced urolithiasis in the urinary bladder of rats is irritation-dependent.
The correlation between urolithiasis due to uracil administration and epithelial proliferation in the urinary bladder was investigated in male F344 rats. Animals, 6 weeks old at the start, which ingested 3% uracil alone in the diet for 4 weeks developed urolithiasis and papillomatosis of the urinary bladder, whereas addition of NaCl, particularly at high concentration (10%), to the 3% uracil in the diet blocked production of both. In contrast, NaHCO3 was without influence on either calculi or proliferative changes. These results indicate that uracil-induced epithelial proliferation is due to direct mechanical irritation by calculi, and not to any chemical stimulus presented by uracil itself.
Kagawa
M
M
1st Department of Pathology, Nagoya City University Medical School, Japan.
Yamamoto
A
A
Ogawa
K
K
Shirai
T
T
Fukushima
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D051381:Rats; D011916:Rats, Inbred F344; D014498:Uracil / Q000633:toxicity*; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology; D014545:Urinary Calculi / Q000139:chemically induced*
D014498:Uracil