New substances against human immunodeficiency virus: sulfated 5'-nucleotidase inhibitory polyphenols.
Two sulfated polyphenols, NF-86II-S-13.3 and NF-86II-S-6.2, were synthesized from NF-86II without sulfur their inhibitory effect on human immunodeficiency virus (HIV) infection in vitro was examined, using cytopathic effect and an antigen expression assay system in MT-4 cells. NF-86II-S-13.3 (sulfur content, 13.3%) completely inhibited the cytopathic effect of HIV and the HIV-specific antigen expression in MT-4 cells at concentrations of more than 6.3 micrograms/ml. The effect of NF-86II-S-6.2 (sulfur content, 6.2%) was much weaker than that of NF-86IIS-13.3. On the other hand, NF-86II without sulfur did not show any activity at all.
Toukairin
T
T
Central Laboratory, Nippon Flour Mills Co., Ltd., Kanagawa, Japan.
Uchino
K
K
Mizuno
T
T
Nakashima
H
H
Yamamoto
N
N
Ogawara
H
H
D015720:5'-Nucleotidase / Q000037:antagonists & inhibitors*; D001557:Benzenesulfonates / Q000138:chemical synthesis / Q000494:pharmacology*; D001704:Biopolymers; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D015488:HIV Antigens / Q000032:analysis; D006801:Humans; D010636:Phenols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D001557:Benzenesulfonates; D001704:Biopolymers; D015488:HIV Antigens; D010636:Phenols; D011108:Polymers; C075211:NF 86II; C075221:NF 86II sulfate; D015720:5'-Nucleotidase