Cocaine elevates striatal dopamine efflux in spontaneously hypertensive and Wistar-Kyoto rats.
The effects of acute cocaine administration on central dopaminergic systems were examined in the striata of spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats with the use of an in vivo microdialysis technique. Increased extracellular levels of dopamine were observed for 45 to 75 minutes following acute cocaine administration in both halothane-anesthetized and conscious SHR and WKY. However, no significant differences were noted between anesthetized and conscious SHR and WKY in either baseline levels or cocaine-induced changes in extracellular levels of dopamine and its metabolites. A positive, linear correlation between extracellular levels of dopamine and cocaine was demonstrated for the 60-min period following acute cocaine administration in both SHR and WKY. The slopes of the linear regression plots obtained from the data of each 15-min sample was slightly, but significantly, higher in conscious SHR than in conscious WKY. The present results suggest a transient and dose-related stimulation of striatal dopamine release following acute cocaine administration and a linear relationship between striatal extracellular levels of dopamine and cocaine in both SHR and WKY.
Inada
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Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216-4505.
Polk
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Purser
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D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000768:Anesthesia, General; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003243:Consciousness; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006719:Homovanillic Acid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012016:Reference Values; D013238:Stereotaxic Techniques; D013997:Time Factors
D015102:3,4-Dihydroxyphenylacetic Acid; D003042:Cocaine; D004298:Dopamine; D006719:Homovanillic Acid