title: Efficacy of ivermectin and pyrantel pamoate combined in a chewable formulation against heartworm, hookworm, and ascarid infections in dogs.
abstract: Eight trials were conducted in dogs to document the efficacy of ivermectin (6 micrograms/kg of body weight) and pyrantel pamoate (5 mg of active pyrantel/kg) in a beef-based chewable formulation against Dirofilaria immitis, Ancylostoma caninum, Uncinaria stenocephala, Toxocara canis, and Toxascaris leonina. Three studies involved induced infection with D immitis, and 5 studies involved induced or natural infection with hookworms and ascarids. In 3 intestinal parasite trials, the efficacy of the combination chewable tablet was compared with each of its components. Results indicated that 1 component did not interfere with the activity of the other. In 1 heartworm and 2 intestinal parasite trials, the efficacy of pyrantel, ivermectin/pyrantel combination, or ivermectin with pyrantel dosage of 10 mg/kg was evaluated. The ivermectin/pyrantel combination was 100% effective in preventing development of D immitis larvae. Efficacy of the combined product against T canis, Toxascaris leonina, A caninum, and U stenocephala was 90.1, 99.2, 98.5, and 98.7%, respectively. In the intestinal parasite trials, each individual component was found not to interfere with the anthelmintic action of the other. Increasing the dosage of pyrantel to 10 mg/kg (2 x that in the combination) did not interfere with the efficacy of ivermectin against heartworm or increase the activity of pyrantel against intestinal parasites.
authors.affiliation: Merck, Sharp & Dohme Research Laboratories, Division of Merck & Co Inc, Rahway, NJ 07065-0900.
authors.forename: J N
authors.initials: JN
authors.lastname: Clark
authors.forename: C P
authors.initials: CP
authors.lastname: Daurio
authors.forename: R E
authors.initials: RE
authors.lastname: Plue
authors.forename: D H
authors.initials: DH
authors.lastname: Wallace
authors.forename: S L
authors.initials: SL
authors.lastname: Longhofer
mesh_terms: D000284:Administration, Oral; D000723:Ancylostomatoidea / Q000187:drug effects; D000724:Ancylostomiasis / Q000188:drug therapy / Q000662:veterinary; D000818:Animals; D004184:Dirofilariasis / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations; D005260:Female; D006725:Hookworm Infections / Q000188:drug therapy / Q000662:veterinary; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*; D013607:Tablets; D014120:Toxocariasis / Q000188:drug therapy / Q000662:veterinary
chemical_list: D004338:Drug Combinations; D013607:Tablets; D007559:Ivermectin; D011716:Pyrantel Pamoate