[Influence of calcium channel blockers and beta-blockers on pain relief with iontophoresis].
We studied usefulness of iontophoresis on pain relief using several Ca channel blockers, propranolol and guanethidine. Subjects were 18 healthy adult volunteers. We used 4% lidocaine with/without several drugs (2 mg of nicardipine, verapamil, diltiazem, propranolol and 10mg of guanethidine), and evaluated the pain relief effect with Nakahama's algesimeter. In all groups except for propranolol group, the pain recognition time was elongated significantly in comparison with control. In making comparison between each Ca channel blocker, we did not observe any significant differences, but, in propranolol group, elongation of pain threshold time was observed in some subjects. During these processes, systemic blood pressure and heart rate showed no remarkable changes. Our results suggest that it is possible to achieve more prolonged analgesic effect by the Ca channel blockers.
Miyagawa
A
A
Department of Anesthesiology, Medical College of Oita.
Taniguchi
K
K
Sendaya
K
K
Mizutani
A
A
Yoshitake
S
S
Ikebe
H
H
Honda
N
N
D000328:Adult; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D005260:Female; D006145:Guanethidine / Q000008:administration & dosage*; D006801:Humans; D007478:Iontophoresis; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D010146:Pain / Q000517:prevention & control*; D011433:Propranolol / Q000008:administration & dosage*
D002121:Calcium Channel Blockers; D008012:Lidocaine; D011433:Propranolol; D006145:Guanethidine