title: Studies on the pathogenesis of bovine ephemeral fever in experimental cattle. III. Virological and biochemical data.
abstract: In an attempt to define the nature of the response of cattle to ephemeral fever infection, a number of indicators of inflammation were monitored during clinical disease. The total Ca, Zn, Fe, Cu, glucose and phosphate in plasma, together with blood ammonia, were assayed relative to changes in the rectal temperature. CaT levels fluctuated markedly and hypocalcaemia occurred in 4 of 8 cattle. Plasma Zn and Fe values fell while plasma Cu levels rose markedly in all cattle. Mean levels of serum NH3 of 20-30 mumol l-1 rose to a peak value of 56 mumoll-1. Plasma glucose levels rose to a peak of 4.6 +/- 0.5 mMl-1 and the plasma phosphate levels fell from 2.4 +/- 0.1 mMl-1 to 1.17 +/- 0.2 mMl-1 during fever. Values of pCO2 fell from a mean of 46.9 +/- 3.6 mmHg to 36.4 +/- 3.1 mmHg and coincided with a rise in pH. Virus was isolated 73 h (+/- 23) after inoculation and persisted until 130 h (+/- 21). The common role of these parameters in generalised inflammation and ephemeral fever is discussed.
authors.affiliation: CSIRO Division of Tropical Animal Production, Long Pocket Laboratories, Indooroopilly, Queensland, Australia.
authors.forename: M F
authors.initials: MF
authors.lastname: Uren
authors.forename: T D
authors.initials: TD
authors.lastname: St George
authors.forename: G M
authors.initials: GM
authors.lastname: Murphy
mesh_terms: D000641:Ammonia / Q000097:blood; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001784:Blood Gas Analysis / Q000662:veterinary; D001786:Blood Glucose / Q000032:analysis; D001831:Body Temperature; D002417:Cattle; D004573:Electrolytes / Q000097:blood; D004810:Ephemeral Fever / Q000097:blood* / Q000382:microbiology; D006863:Hydrogen-Ion Concentration; D007958:Leukocyte Count / Q000662:veterinary; D010710:Phosphates / Q000097:blood; D012209:Rhabdoviridae / Q000276:immunology / Q000302:isolation & purification*; D014766:Viremia / Q000097:blood / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral; D001786:Blood Glucose; D004573:Electrolytes; D010710:Phosphates; D000641:Ammonia