[Experimental study on the mechanism of free radical in blast trauma induced hearing loss].
The MDA content in the cochlear tissue and ABR hearing threshold were measured at different times after the explosion of the guinea pigs. Results showed that there were two high peak values. The MDA increases at one hour after explosion; at 3 and 6 days it was significantly increased (first peak); at 8 days it reduced to normal level; at 12 days it again remarkably increased (second peak). It was in accordance with ABR hearing threshold changes. This suggests that increasing oxygen free radical reaction may be one of the causes of damage in blast trauma induced hearing loss.
Liu
Z
Z
Xijing Hospital, Fourth Military Medical University, Xian.
D000818:Animals; D001753:Blast Injuries / Q000150:complications*; D003051:Cochlea / Q000293:injuries* / Q000378:metabolism; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism
D005609:Free Radicals; D008315:Malondialdehyde