title: Directional asymmetry of the frog monocular optokinetic nystagmus: cholinergic modulation.
abstract: The frog monocular optokinetic gaze nystagmus (OKN) was studied by coil recordings after intravitreal administration of cholinergic drugs into the closed eye. Before injection, the frog displayed OKN for stimulations in the temporo-nasal (T-N) direction only. The injection of muscarinic agonists, as well as that of nicotinic antagonists, provoked the appearance of a naso-temporal (N-T) component, the slow phase velocity gain then being strongly and significantly increased. The abolition of the OKN directional asymmetry indicates that acetylcholine seems to act in opposite ways through muscarinic and nicotinic binding sites. The GABAergic and cholinergic systems may interact to generate and modulate OKN in the frog.
authors.affiliation: D.N.B.C., Centre de Neurochimie du CNRS, Strasbourg, France.
authors.forename: B
authors.initials: B
authors.lastname: Jardon
authors.forename: Y H
authors.initials: YH
authors.lastname: Yucel
authors.forename: N
authors.initials: N
authors.lastname: Bonaventure
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D009760:Nystagmus, Physiologic / Q000502:physiology*; D011893:Rana esculenta / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology; D011978:Receptors, Nicotinic / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology
chemical_list: D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D000109:Acetylcholine