A genetic linkage study of schizophrenia to chromosome 5 markers in a northern Italian population.
Some recent findings report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigrees segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.
Macciardi
F
F
Istituto Scientifico H San Raffaele, Clinical Psychiatry 3rd, Milan University School of Medicine, Italy.
Kennedy
J L
JL
Ruocco
L
L
Giuffra
L
L
Carrera
P
P
Marino
C
C
Rinaldi
V
V
Smeraldi
E
E
Ferrari
M
M
D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D007558:Italy; D010375:Pedigree; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
D005819:Genetic Markers