title: Effect of ventilation with positive end-expiratory pressure on the development of lung damage in experimental acid aspiration pneumonia in the rabbit.
abstract: Sixteen anaesthetized rabbits were subjected to tracheostomy and lung damage produced by the instillation of 4.5 ml/kg hydrochloric acid (pH 1.5) into the trachea. Half of the animals were ventilated with a positive end-expiratory pressure (PEEP) of 3 cmH2O and half with a PEEP of 10 cmH2O for 5 h, the mean airway pressure being kept at 12 cmH2O by adjustment of the end-inspiratory pause time. Pressure-volume curves were recorded every hour. Although the arterial PO2 values and compliance above the inflection point on the pressure-volume curve were greater in the group submitted to 10 cmH2O PEEP, there were no significant differences between the groups in terms of survival and histological findings.
authors.affiliation: Nuffield Department of Anaesthetics, University of Oxford, UK.
authors.forename: A
authors.initials: A
authors.lastname: Sohma
authors.forename: W J
authors.initials: WJ
authors.lastname: Brampton
authors.forename: M S
authors.initials: MS
authors.lastname: Dunnill
authors.forename: M K
authors.initials: MK
authors.lastname: Sykes
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D006801:Humans; D006819:Hyaline Membrane Disease / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D007231:Infant, Newborn; D008170:Lung Compliance; D008176:Lung Volume Measurements; D009504:Neutrophils / Q000473:pathology; D010100:Oxygen / Q000097:blood; D011015:Pneumonia, Aspiration / Q000628:therapy*; D011175:Positive-Pressure Respiration / Q000009:adverse effects* / Q000379:methods; D011817:Rabbits; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate
chemical_list: D010100:Oxygen