Renal elimination of verbenols in man following experimental alpha-pinene inhalation exposure.
The renal elimination of verbenols after experimental exposure to (+) and (-)alpha-pinene was studied in humans following exposure to 10, 225, and 450 mg.m-3 terpene in an exposure chamber. The pulmonary uptake was about 60%. About 8% was eliminated unchanged in exhaled air. Depending on the exposure level, about 1%-4% of the total uptake was eliminated as cis- and trans-verbenol. Most of the verbenols were eliminated within 20 h after a 2-h exposure. The renal excretion of unchanged alpha-pinene was less than 0.001%.
Levin
J O
JO
National Institute of Occupational Health, Umeå, Sweden.
Eriksson
K
K
Falk
A
A
Löf
A
A
D000328:Adult; D000081008:Bicyclic Monoterpenes; D004781:Environmental Exposure / Q000032:analysis*; D006801:Humans; D008297:Male; D039821:Monoterpenes; D013729:Terpenes / Q000652:urine*
D000081008:Bicyclic Monoterpenes; D039821:Monoterpenes; D013729:Terpenes; C009951:verbenol; C005451:alpha-pinene