title: Echocardiographic and angiographic evaluation of left ventricular function during percutaneous transluminal aortic valvuloplasty.
abstract: Transesophageal echocardiography was used to study the effect of the balloon inflation on left ventricular function in 20 patients with critical aortic stenosis undergoing balloon valvuloplasty. Balloon inflation caused an increase of end-diastolic (15% to 34%) and end-systolic (57% to 72%) left ventricular volume. Left ventricular wall stress increased from 30 +/- 10 x 10(3) dyn/cm2 at diastole and 121 +/- 40 x 10(3) dyn/cm2 at systole to 44 +/- 11 x 10(3) dyn/cm2 and 191 +/- 55 x 10(3) dyn/cm2, respectively, when the balloon was inflated (P less than 0.05). Turbulent regurgitant jet across the mitral valve increased from 15 +/- 2% to 25 +/- 3% during balloon inflation (P less than 0.01). Continued monitoring of left ventricular function after balloon deflation demonstrated prolonged enlargement of left ventricular volumes. Our data show that balloon inflation causes an increase of left ventricular volume and impairment of contraction. Increase of left ventricular wall stress--associated with a reduction of coronary blood flow, due to lower aortic pressure--could result in ischemic myocardial injury.
authors.affiliation: II. Medical Clinic, University of Mainz, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Sack
authors.forename: K J
authors.initials: KJ
authors.lastname: Henrichs
authors.forename: R
authors.initials: R
authors.lastname: Erbel
authors.forename: N
authors.initials: N
authors.lastname: Wittlich
authors.forename: J
authors.initials: J
authors.lastname: Meyer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000503:physiopathology; D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000628:therapy*; D002302:Cardiac Output / Q000502:physiology; D002404:Catheterization; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology; D004452:Echocardiography; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology*; D012307:Risk Factors; D016277:Ventricular Function, Left / Q000502:physiology*