[Induction of manganese superoxide dismutase in ovarian carcinoma].
A monoclonal antibody against manganese superoxide dismutase (Mn-SOD) was assessed for its use in detecting a marker for epithelial ovarian carcinoma. An enzyme-linked immunosorbent assay has been developed to detect serum Mn-SOD. With this assay, only 1.7% of the 240 healthy females tested had more than 130 ng per milliliter of serum Mn-SOD. In contrast, 39 of 66 patients (59.1%) with epithelial ovarian carcinoma showed high levels of Mn-SOD. The serum Mn-SOD increased according to the clinical stage and declined to reflect the effect of therapy. The determination of Mn-SOD levels proved to be a clinical useful marker for monitoring the response to treatment and to early detection of the recurrence of epithelial ovarian carcinomas.
Ishikawa
M
M
Department of Obstetrics and Gynecology, Asahikawa Medical College.
Nakata
T
T
Shimizu
T
T
Taniguchi
N
N
D000293:Adolescent; D000328:Adult; D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood*; D002648:Child; D004796:Clinical Enzyme Tests; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000201:enzymology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013482:Superoxide Dismutase / Q000096:biosynthesis / Q000097:blood*
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D013482:Superoxide Dismutase