Could a lowered level of uncoupling protein in brown adipose tissue mitochondria play a role in SIDS aetiology?
Previously published studies on the relationship between brown adipose tissue thermogenesis and sudden infant death were examined and evidence was collated to support the hypothesis that a decreased level of mitochondrial uncoupling protein (or thermogenin) from the brown fat in some brown fat depots may play a role in SIDS aetiology.
Douglas
R J
RJ
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007473:Ion Channels; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D008954:Models, Biological; D013398:Sudden Infant Death / Q000209:etiology*; D014475:Uncoupling Agents / Q000378:metabolism; D000071256:Uncoupling Protein 1
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D014475:Uncoupling Agents; D000071256:Uncoupling Protein 1