[Strategy for therapy of malignant ascites using MTT assay].
Since the prognosis of patients with malignant ascites is generally poor, the establishment of a therapeutic plan should be done as soon as possible. In order to select the most suitable antitumor agent, a drug-sensitivity test was done by MTT assay using fresh autologous tumor cells as targets. Autologous tumor cells were collected from their ascitic fluids. Results obtained here indicate a possible strategy for the treatment of patients with malignant ascites by MTT assay.
Katano
M
M
Dept. of Surgery, Saga Medical School.
Oogushi
K
K
Morita
H
H
Sunaga
T
T
Matsunaga
H
H
Yamamoto
H
H
Hisatsugu
T
T
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001202:Ascitic Fluid / Q000188:drug therapy / Q000473:pathology*; D001943:Breast Neoplasms / Q000150:complications; D002945:Cisplatin / Q000494:pharmacology; D002985:Clinical Protocols; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D016685:Mitomycin / Q000494:pharmacology; D013274:Stomach Neoplasms / Q000150:complications; D013778:Tetrazolium Salts; D013844:Thiazoles; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D016685:Mitomycin; D004317:Doxorubicin; C022616:thiazolyl blue; D002945:Cisplatin; D005472:Fluorouracil