Autografting and PUVA. A combination therapy for vitiligo.
A novel approach to the management of vitiligo is described using a combination of epidermal autografts transplanted into the depigmented areas and psoralen-ultraviolet-A (PUVA) therapy. Epidermal autografts can be obtained rapidly and in large numbers using a device that combines the synergistic effects of suction and heat on the skin. Subsequent exposure to PUVA therapy promotes spread of pigmentation out of the grafts resulting in even and complete pigmentation. In certain situations, the combination therapy appears to offer the potential for avoiding the disadvantages of both of the two treatments when they are used alone. This article presents our preliminary work in the development of the methodology for this combined approach.
Skouge
J W
JW
Department of Otolaryngology/Head and Neck Surgery, Greater Baltimore Medical Center, Maryland.
Morison
W L
WL
Diwan
R V
RV
Rotter
S
S
D003131:Combined Modality Therapy; D004817:Epidermis / Q000637:transplantation*; D006801:Humans; D011701:PUVA Therapy; D012880:Skin Pigmentation; D013396:Suction; D014182:Transplantation, Autologous / Q000295:instrumentation / Q000379:methods; D014820:Vitiligo / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*