title: Combined effect of smoking habits and occupational exposure to hard metal on total IgE antibodies.
abstract: A survey was made within a population of workers (n = 706) exposed to hard metal dust (an alloy including cobalt), an agent known to cause occupational allergy. Twenty-seven (4 percent) of 733 workers were eliminated from consideration in this study because of atopic status identified prior to starting work in the plant. Using a Phadebas PRIST, the subjects' total IgE levels were determined and related to their smoking and exposure status. Nonexposed male smokers (n = 135) had a higher geometric mean IgE level (39.7 IU/ml) than did nonexposed subjects who had never smoked (33.1 IU/ml; n = 99); those with a higher Brinkman index (greater than 300), a smoking index obtained by multiplying the number of cigarettes per day by the duration of smoking in years, had significantly (p less than 0.05) decreased IgE levels. Although ex-smokers (n = 72) had a higher geometric mean IgE level (73.3 IU/ml) than did those who had never smoked, their serum IgE level declined with age since the time they quit smoking, regardless of their hard metal exposure status. Hard metal (cobalt) exposure may play a significant role as an adjuvant in the production of total IgE. A multivariate analysis demonstrated that hard metal exposure and a smoking habit together arithmetically (p less than 0.05) increased total IgE levels. These two factors may be preventable risk factors for occupational allergy in hard metal workers.
authors.affiliation: Department of Hygiene and Preventive Medicine, School of Medicine, Osaka University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shirakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kusaka
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
mesh_terms: D000328:Adult; D003035:Cobalt / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004391:Dust / Q000009:adverse effects; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000187:drug effects*; D007564:Japan / Q000453:epidemiology; D008669:Metallurgy; D008875:Middle Aged; D015999:Multivariate Analysis; D009784:Occupational Diseases / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D016273:Occupational Exposure / Q000009:adverse effects*; D015995:Prevalence; D012130:Respiratory Hypersensitivity / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects / Q000276:immunology*
chemical_list: D004391:Dust; D007073:Immunoglobulin E; D003035:Cobalt