Human immunodeficiency virus type 1 enhances intracellular growth of Mycobacterium avium in human macrophages.
Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human macrophages. Human monocytes isolated from the peripheral blood of healthy individuals were infected with HIV-1, M. avium, or both. The intracellular growth of M. avium and the replication of HIV-1 were monitored for up to 5 weeks. Intracellular mycobacterial growth was seen in all M. avium infected cell cultures and was paralleled by increased production of interleukin 1 alpha and beta. Preinfection of the macrophages with HIV-1 reduced the interleukin 1 production and accelerated the intracellular growth of M. avium. These findings may explain in part the impaired control of mycobacterial infections seen with patients with AIDS.
Källenius
G
G
National Bacteriological Laboratory, Karolinska Institute, Stockholm, Sweden.
Koivula
T
T
Rydgård
K J
KJ
Hoffner
S E
SE
Valentin
A
A
Asjö
B
B
Ljungh
C
C
Sharma
U
U
Svenson
S B
SB
D002478:Cells, Cultured; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D008264:Macrophages / Q000382:microbiology*; D009162:Mycobacterium avium / Q000254:growth & development*; D014779:Virus Replication
D007375:Interleukin-1