[Antibacterial prophylaxis in heart surgery interventions with extracorporeal circulation].
Clinico-laboratory studies were conducted in 30 patients who underwent operations for heart diseases and thromboembolism of the pulmonary artery under extracorporeal circulation. Gentamicin and tobramycin were used for antibacterial prophylaxis. Study of the pharmacokinetics of the agents disclosed essential changes of the distribution volume and clearance of the antibiotics in the patients of the studied group, which made the routine regimen of their administration modified. Analysis of the results of administration of the agents according to a modulatory regimen showed its high prophylactic efficacy in the absence of side effects.
Gel'fand
B R
BR
Gologorskiĭ
V A
VA
Razzhivin
V P
VP
Grinenko
T F
TF
Kleĭmenov
O N
ON
Alekseeva
E A
EA
D000293:Adolescent; D000328:Adult; D005112:Extracorporeal Circulation; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D006349:Heart Valve Diseases / Q000601:surgery*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011655:Pulmonary Embolism / Q000601:surgery; D014031:Tobramycin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
D005839:Gentamicins; D014031:Tobramycin
Antibakterial'naia profilaktika pri kardiokhirurgicheskikh vmeshatel'stvakh v usloviiakh iskusstvennogo krovoobrashcheniia.