New penem compounds with 5'-substituted pyrrolidinylthio group as a C-2 side chain; comparison of their biological properties with those of carbapenem compounds.
A series of new penem compounds with a C-2 side chain consisting of a pyrrolidin-3'-ylthio group substituted with various aminocarbonyl groups at the C-5' position have been prepared. Antibacterial activity, stability to renal dehydropeptidase-I and affinity to penicillin-binding proteins of these compounds were investigated and compared with the corresponding carbapenem compounds.
Sunagawa
M
M
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.
Matsumura
H
H
Inoue
T
T
Fukasawa
M
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D015780:Carbapenems / Q000138:chemical synthesis / Q000494:pharmacology*; D004355:Drug Stability; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007769:Lactams; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007769:Lactams; C074828:(5-dimethylaminocarbonylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid