title: Spectrum of tuberculosis in patients with HIV infection in British Columbia: report of 40 cases.
abstract: OBJECTIVE
  To review the clinical features, treatment and outcome of all known cases of tuberculosis in patients with human immunodeficiency virus (HIV) infection in British Columbia between 1984 and 1990.
  
  
  METHODS
  Retrospective case review.
  
  
  METHODS
  Provincial tuberculosis registry and university-affiliated HIV clinic.
  
  
  METHODS
  All people with HIV infection in whom active tuberculosis was diagnosed during the study period.
  
  
  RESULTS
  All 40 patients identified were men; their mean age was 38 years. Of the subjects 30 (75%) were homosexual, 6 (15%) were homosexual and used intravenous drugs, 2 (5%) just used intravenous drugs, and 1 (2%) had had heterosexual contact with prostitutes; for the remaining subject the risk factor for HIV infection was not established. In all cases cultures of specimens from 15 body sources yielded Mycobacterium tuberculosis. Thirty-five of the patients had acquired immunodeficiency syndrome (AIDS), and five had HIV infection uncomplicated except for tuberculosis. In 28 (70%) of the cases no AIDS-defining disease had previously been diagnosed, and in 23 (58%) extrapulmonary tuberculosis represented the AIDS-defining disease. Symptoms at presentation included weight loss (in 80% of the cases), fever (in 75%), cough (in 70%) and night sweats (in 55%). The mean CD4 lymphocyte count was 0.2 x 10(9)/L (in 15 cases). Tuberculin skin test results were positive in 8 of 16 cases. The most striking radiologic finding was intrathoracic adenopathy. All except one of the 36 patients who received appropriate treatment responded favourably at first. Adverse reactions necessitating changes in treatment occurred in 12 (33%) of the cases. Relapse occurred after completion of therapy in two cases (one at 3 weeks and the other at 9 months after treatment was stopped). Tuberculosis was the cause of death in five cases.
  
  
  CONCLUSIONS
  Tuberculosis in people with HIV infection commonly presents as extrapulmonary disease and precedes or coincides with other AIDS-defining opportunistic infections. In most cases tuberculosis is the AIDS-defining disease. Even though radiologic findings are often unusual physicians should suspect tuberculosis. A careful examination for evidence of disease at multiple sites should be done. The duration and choice of therapy must be adequate to avoid relapse.
authors.affiliation: Department of Medicine, University of British Columbia, Vancouver.
authors.forename: M
authors.initials: M
authors.lastname: Korzeniewska-Kosela
authors.forename: J M
authors.initials: JM
authors.lastname: FitzGerald
authors.forename: S
authors.initials: S
authors.lastname: Vedal
authors.forename: E A
authors.initials: EA
authors.lastname: Allen
authors.forename: M T
authors.initials: MT
authors.lastname: Schechter
authors.forename: L
authors.initials: L
authors.lastname: Lawson
authors.forename: P
authors.initials: P
authors.lastname: Phillips
authors.forename: W
authors.initials: W
authors.lastname: Black
authors.forename: J S
authors.initials: JS
authors.lastname: Montaner
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000453:epidemiology; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001955:British Columbia; D006716:Homosexuality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents