title: Superantigens.
abstract: Over the past three years superantigens have come to the forefront of immunological research. Studies in a number of laboratories have indicated that superantigens play a central role in shaping the T-cell repertoire in the development of tolerance, autoimmunity and immunodeficiency. This is in addition to their classic role in the pathogenesis of a number of infectious diseases.
authors.affiliation: Harvard Medical School, Boston, Massachusetts.
authors.forename: T
authors.initials: T
authors.lastname: Chatila
authors.forename: R S
authors.initials: RS
authors.lastname: Geha
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D001665:Binding Sites; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D012190:Retroviridae / Q000276:immunology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000941:Antigens; D000942:Antigens, Bacterial; D000956:Antigens, Viral; D001324:Autoantigens; D000949:Histocompatibility Antigens Class II; D011948:Receptors, Antigen, T-Cell