Dynamic cardiomyoplasty for hemodynamic support during acute pulmonary hypertension. An experimental study.
The efficacy of dynamic cardiomyoplasty for hemodynamic support during acute pulmonary hypertension was studied. Five dogs underwent a right latissimus dorsi cardiomyoplasty. Each dog was later studied in a short-term experiment. A graded acute pulmonary hypertension was induced by infusion of glass microspheres into the pulmonary artery. This resulted in decrease in pulmonary artery flow, systemic pressure, and systemic flow. The cardiomyoplasty was then stimulated with a new R wave synchronous rate-responsive pulse-train stimulator (Prometheus system). This pacemaker delivers a pulse train with the duration of stimulation determined as a proportion of the RR interval. At an optimal level of hemodynamic impairment, the dynamic cardiomyoplasty was able to immediately improve pulmonary artery flow 26.4% +/- 5.84% (standard error of the mean) (p less than 0.005, paired t test), mean systemic arterial pressure 11.6% +/- 3.7% (p less than 0.05), and thoracic aortic flow 15.7% +/- 6.3% (p less than 0.05). The degree of improvement in hemodynamic variables could be correlated with the magnitude of hemodynamic impairment present (e.g., r = 0.78; p less than 0.005 for pulmonary blood flow). We conclude that a significant beneficial effect of dynamic cardiomyoplasty on hemodynamics in short-term canine pulmonary hypertension is demonstrated in this study. Thus cardiomyoplasty may be useful in patients with right heart failure associated with increased pulmonary vascular resistance.
Hill
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Department of Surgery, Montreal General Hospital/McGill University, Quebec, Canada.
Li
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Tchervenkov
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Desrosiers
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Chiu
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RC
D000208:Acute Disease; D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods*; D004195:Disease Models, Animal; D004285:Dogs; D004567:Electrodes, Implanted; D005069:Evaluation Studies as Topic; D006439:Hemodynamics / Q000502:physiology; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D010138:Pacemaker, Artificial; D011652:Pulmonary Circulation / Q000502:physiology; D013524:Surgical Flaps / Q000379:methods*; D013536:Suture Techniques