Aplastic anemia in a male with loss of the Y chromosome.
We carried out chromosomal analysis of a 33-year-old male who was diagnosed as having aplastic anemia. The patient showed severe pancytopenia, a normal NAP score, hypoplastic marrow and no myelodysplastic changes. 45,XO was found in all bone marrow cells examined, and in 10% of peripheral blood cells examined. To our knowledge, this is the first reported case of male aplastic anemia to show loss of the Y chromosome in all bone marrow cells examined, and this case may suggest a possible mechanism of juvenile onset of aplastic anemia.
Matsuguchi
T
T
Department of Internal Medicine, Sasebo Kyosai Hospital, Japan.
Goto
H
H
Fukumoto
T
T
Okamura
S
S
Niho
Y
Y
D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D000782:Aneuploidy; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D014998:Y Chromosome