Serotonergic influence on cholinergic-induced analgesia: differences in two inbred strains of mice.
C57BL/6 (C57) and DBA/2 (DBA) inbred mice showed different analgesic responses to cholinergic stimulation. The simultaneous administration of muscarinic and serotonergic agonists, oxotremorine and 5-methoxy-NN-dimethyltryptamine (5-MeODMT), lowered the antinociceptive effect of the cholinergic drug in DBA mice, while no effects were detectable in the C57 strain. These results suggest a strain-dependent behavioural effect of the interaction of cholinergic and serotonergic neuronal systems.
Pavone
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Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Fagioli
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S
D000109:Acetylcholine / Q000502:physiology*; D000698:Analgesia; D000818:Animals; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL / Q000502:physiology*; D008811:Mice, Inbred DBA / Q000502:physiology*; D010095:Oxotremorine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology*; D013045:Species Specificity
D008732:Methoxydimethyltryptamines; D012701:Serotonin; D010095:Oxotremorine; D000109:Acetylcholine