Effects of nicardipine in rats subjected to endotoxic shock.
1. The calcium channel blocker, nicardipine, produced a dose-dependent reduction in the mortality caused by endotoxin in rats. 2. The drug also reduced most of the hematological and gross pathological manifestations of disseminated intravascular coagulation (DIC) caused by endotoxin. 3. The endotoxin-induced monocytopenia but not the granulocytopenia, lymphocytopenia or thrombocytopenia was inhibited by the drug. 4. The results suggest that the protective action of nicardipine is causally related to prevention of the endotoxin-induced DIC and that an effect of the drug on monocytes may be of importance.
Lee
H C
HC
Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822.
Hardman
J M
JM
Lum
B K
BK
D000704:Analysis of Variance; D000818:Animals; D001772:Blood Cell Count; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D008297:Male; D009000:Monocytes / Q000187:drug effects; D009529:Nicardipine / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology
D004731:Endotoxins; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D009529:Nicardipine