Further antigenic similarities of Neisseria gonorrhoeae lipooligosaccharides and human glycosphingolipids.
Anticarbohydrate monoclonal antibodies were tested for their ability to bind to various strains of Neisseria. A monoclonal antibody that binds to the ganglio-series glycosphingolipid, ganglio-N-triaosylceramide, also bound to strains of Neisseria gonorrhoeae but not to other species of Neisseria. An antibody specific for the globo-series glycosphingolipid, globotriaosylceramide, also bound to strains of N. gonorrhoeae, Neisseria meningitidis, Neisseria lactamica, and Branhamella catarrhalis but not to any other strains of nonpathogenic Neisseria.
Mandrell
R E
RE
Centre for Immunochemistry, Veterans Administration Medical Center, San Francisco, California 94121.
D000911:Antibodies, Monoclonal; D002240:Carbohydrate Sequence; D003429:Cross Reactions; D006028:Glycosphingolipids / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D008969:Molecular Sequence Data; D001936:Moraxella catarrhalis / Q000276:immunology; D009343:Neisseria / Q000276:immunology; D009344:Neisseria gonorrhoeae / Q000276:immunology*; D011863:Radioimmunoassay
D000911:Antibodies, Monoclonal; D006028:Glycosphingolipids; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides