Protective effect on cisplatin hematotoxicity by procaine hydrochloride.
The ability of procaine hydrochloride (P.HCl) to modulate the effects of cisplatin (DDP) on pluripotent (CFU-S) and committed (CFU-GM) murine hemopoietic stem cells was investigated. DBA/2NCrlBRF1 mice received DDP alone (10 and 16 mg/kg body wt. single i.p. injection) or in combination with P.HCl (40 mg/kg body wt. single i.p. injection). Hemopoietic progenitor cell (HPC) time survival curves were determined up to 14 days following treatment. The simultaneous administration of the lower DDP dose together with P.HCl greatly reduced the hemotoxicity of the antitumoral drug, while this protection was not significant with the higher DDP dose. These results support a role for P.HCl in protecting against DDP hematological toxicity.
Esposito
M
M
Servizio di Farmacologia Tossicologica, University of Genoa, Italy.
Lerza
R
R
Mencoboni
M
M
Vannozzi
M
M
Flego
G
G
Bogliolo
G
G
Merlo
F
F
Pannacciulli
I
I
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA
D008012:Lidocaine; D002945:Cisplatin