title: Determination of nifedipine in plasma by a rapid capillary gas chromatographic method.
abstract: A rapid, specific and reliable gas chromatographic assay procedure for Nifedipine in plasma has been developed. With a single-step solvent extraction, and electron capture detection, the method is sensitive to 0.5 ng/mL of plasma and the standard curve is linear from 0.5 to 500 ng/mL. Samples are protected from light to prevent formation of photodecomposition products. The method has been used to monitor drug concentrations in patients receiving therapeutic doses.
authors.affiliation: Laboratoire Hospitalo-Universitaire de Pharmacocinétique et Toxicocinétique, Chu Timone, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Le Guellec
authors.forename: H
authors.initials: H
authors.lastname: Bun
authors.forename: M
authors.initials: M
authors.lastname: Giocanti
authors.forename: A
authors.initials: A
authors.lastname: Durand
mesh_terms: D002849:Chromatography, Gas; D006801:Humans; D009543:Nifedipine / Q000097:blood*; D015203:Reproducibility of Results
chemical_list: D009543:Nifedipine