Activin synergistically increased c-jun mRNA in P19 embryonal carcinoma cells in the presence of retinoic acid.
Activin and retinoids, which are involved in the induction and regulation of the early differentiation process in vertebrate embryogenesis, synergistically increased the amount of c-jun mRNA in P19 embryonal carcinoma cells, but activin alone had no effect. Among the retinoids, all-trans-retinoic acid most effectively increased c-jun mRNA. Activin (lng/ml) was sufficient to induce the synergistic increase of c-jun mRNA in P19 EC cells with all-trans-retinoic acid. The synergistic increase of the amount of c-jun mRNA by their cooperative action may be important in vertebrate development.
Momoi
T
T
National Institute of Neuroscience, NCNP, Tokyo, Japan.
Kawai
Y
Y
Momoi
M
M
Etoh
Y
Y
D028341:Activins; D000818:Animals; D002460:Cell Line; D004357:Drug Synergism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D016758:Genes, jun / Q000187:drug effects*; D006133:Growth Substances / Q000494:pharmacology*; D007265:Inhibins / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D013724:Teratoma; D014158:Transcription, Genetic / Q000187:drug effects*; D014212:Tretinoin / Q000494:pharmacology*
D006133:Growth Substances; D012333:RNA, Messenger; D028341:Activins; D014212:Tretinoin; D007265:Inhibins