title: [Antagonistic properties of tetra-substituted analog of vasopressin with selective antidiuretic effects].
abstract: Biological properties of a novel vasopressin analogue were investigated. It was found that this analogue has no vasopressor and oxytocic activities but it exhibits a selective antidiuretic effect which is weaker than that of adiuretin (DDAVP). Novel analogue inhibits vasopressor, oxytocic and antidiuretic effects caused by arginine--vasopressin. The usefulness of novel compound as a pharmacological tool--vasopressin antagonist is suggested.
authors.forename: N V
authors.initials: NV
authors.lastname: Myshliakova
authors.forename: G A
authors.initials: GA
authors.lastname: Afanas'eva
authors.forename: G M
authors.initials: GM
authors.lastname: Strazda
authors.forename: O S
authors.initials: OS
authors.lastname: Papsuevich
authors.forename: N V
authors.initials: NV
authors.lastname: Klusha
authors.forename: G I
authors.initials: GI
authors.lastname: Chipens
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D004232:Diuretics / Q000037:antagonists & inhibitors*; D005260:Female; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D004232:Diuretics; D001127:Arginine Vasopressin; C025043:vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-; D003894:Deamino Arginine Vasopressin
vernacular_title: Antagonisticheskie svoĭstva chetyrekhzameshchennogo analoga vazopressina s selektivnym antidiureticheskim deĭstviem.