title: Acute toxicity, uptake and clearance of diazinon by the European eel, Anguilla anguilla (L.).
abstract: The toxicity, accumulation, and elimination of diazinon were investigated for the european eel, Anguilla anguilla. The 24, 48, 72 and 96-h median lethal concentrations (LC50) were 0.16, 0.11, 0.09 and 0.08 mg/L, respectively. Fish exposed to sublethal concentration (0.042 mg/L) accumulated diazinon in liver and muscle tissues. Bioconcentration factors (BCF) of diazinon were 1850 in liver, and 775 in muscle over the 96-h exposure period. Upon removal from diazinon containing water the contaminated fish rapidly eliminated diazinon. The excretion rate constants of this insecticide were 0.108 h-1 for liver and 0.016 h-1 for muscle. Diazinon half-lives were 16.6 and 33.2 hours for liver and muscle, respectively.
authors.affiliation: Dept. Animal Physiology, Faculty of Biological Sciences, University of Valencia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Sancho
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrando
authors.forename: E
authors.initials: E
authors.lastname: Andreu
authors.forename: M
authors.initials: M
authors.lastname: Gamon
mesh_terms: D000811:Anguilla / Q000378:metabolism*; D000818:Animals; D003976:Diazinon / Q000493:pharmacokinetics* / Q000633:toxicity; D004350:Drug Residues / Q000493:pharmacokinetics*; D006207:Half-Life; D007928:Lethal Dose 50; D008099:Liver / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D012119:Respiration; D012995:Solubility; D014018:Tissue Distribution
chemical_list: D003976:Diazinon