title: Antithrombotic activity of verapamil.
abstract: The antithrombotic activity of verapamil (Ver) was assessed in an arterial thrombosis model and an ex vivo thrombosis model. Ver 2 and 4 mg.kg-1 ip markedly prolonged the time of thrombotic occlusion in rat carotid artery induced by electric stimulation. The weight of thrombus formed ex vivo was reduced by Ver 0.2 mg.kg-1 iv. However, Ver showed no effects on blood viscosity.
authors.affiliation: Thrombosis Research Centre, Shenzhen Institute of Geriatrics, China.
authors.forename: C L
authors.initials: CL
authors.lastname: Liao
authors.forename: Q J
authors.initials: QJ
authors.lastname: Zou
authors.forename: J M
authors.initials: JM
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Cui
authors.forename: N R
authors.initials: NR
authors.lastname: Yuan
mesh_terms: D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D005260:Female; D008297:Male; D011817:Rabbits; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy* / Q000517:prevention & control; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014700:Verapamil