Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting.
The mouse homolog of the human proto-oncogene MAS was mapped by two interspecific backcrosses to the proximal portion of MMU17. Higher resolution mapping was accomplished through the analysis of genotypes duplicated or deleted for a megabase-size subregion within MMU17. The results demonstrate a map position for Mas in the close vicinity of Igf2r, which encodes another membrane receptor known to undergo genomic imprinting. The data provide further evidence for the clustering of genes in a 1-Mb region of chromosome 17, with the absence of any identified genes in a nearby region likely to be six times larger.
Cebra-Thomas
J A
JA
Department of Molecular Biology, Princeton University, New Jersey 08544-1014.
Tsai
J Y
JY
Pilder
S H
SH
Copeland
N G
NG
Jenkins
N A
NA
Silver
L M
LM
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005819:Genetic Markers; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice / Q000235:genetics*; D009115:Muridae / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D013045:Species Specificity
D005819:Genetic Markers; C000715470:MAS1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D000090063:Proto-Oncogene Mas