The effect of baseline complex ovarian cysts on in vitro fertilization outcome.
OBJECTIVE
To determine the effect of baseline complex ovarian cysts on controlled ovarian hyperstimulation and in vitro fertilization (IVF) outcome.


METHODS
Retrospective analysis with stratification by stimulation regimen and the presence or absence of surgically documented endometriosis.


METHODS
Two hundred sixty-one women undergoing IVF from May 1, 1989 to December 31, 1990.


METHODS
The outcome measures assessed were the maximum estradiol (E2) concentration on day of human chorionic gonadotropin (hCG) administration, number of follicles with maximum diameter greater than or equal to 15 mm, number of follicles with maximum diameter greater than or equal to 12 mm, number of days to hCG administration, number of ampules of human menopausal gonadotropin (hMG) used, number of oocytes retrieved and fertilized, number of embryos transferred, and pregnancy and cycle cancellation rates.


RESULTS
There were no statistical differences between cyst and noncyst groups in any of the above parameters of IVF performance. In a single subgroup, patients with endometriosis stimulated with hMG and patients with cysts had significantly lower E2 concentrations than patients without cysts.


CONCLUSIONS
The presence of a complex cyst on a baseline ultrasound does not appear to adversely affect IVF cycle outcomes.
Stewart
E A
EA
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Jackson
K V
KV
Friedman
A J
AJ
Rein
M S
MS
Fox
J H
JH
Hornstein
M D
MD
D004715:Endometriosis / Q000503:physiopathology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D010048:Ovarian Cysts / Q000503:physiopathology*; D011247:Pregnancy; D012189:Retrospective Studies
D016729:Leuprolide