The contribution of epinephrine to experimentally induced urethral inflammation in the rat.
We have studied the effect of the adrenal medulla and epinephrine on experimentally induced urethral inflammation in the rat. Urethral inflammation was induced by inserting latex strips into the urethra. The effects of different experimental procedures were assessed by using a 4-graded inflammation scale based on histological findings. Adrenal medullectomy significantly reduced experimentally induced urethral inflammation. This effect was reversed if the rats were treated repeatedly with epinephrine or salbutamol. On the other hand high doses of epinephrine reduced the experimentally induced urethral inflammation.
Nordling
L
L
Department of Physiology II, Karolinska Institutet, Stockholm, Sweden.
Lundeberg
T
T
Liedberg
H
H
Theodorsson
E
E
Ekman
P
P
D000313:Adrenal Medulla / Q000502:physiology; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D004837:Epinephrine / Q000502:physiology*; D005260:Female; D005976:Glutaral / Q000494:pharmacology; D007840:Latex; D051381:Rats; D011919:Rats, Inbred Strains; D014526:Urethritis / Q000139:chemically induced / Q000503:physiopathology*; D001743:Urinary Bladder / Q000502:physiology
D007840:Latex; D000420:Albuterol; D005976:Glutaral; D004837:Epinephrine