title: Influence on hormone levels, lipid metabolism and reversibility of endocrinological changes after leuprorelin acetate depot therapy.
abstract: The effect of leuprorelin acetate depot on the endocrine system and on lipid metabolism was evaluated in a multicentre, noncomparative study. During the first month of treatment, suppression of serum oestradiol levels to below 20 pg/ml was achieved and luteinising hormone and follicle-stimulating hormone levels were reduced to less than 50% of pretreatment values. A negative influence on lipid metabolism was not recorded. The high-density lipoprotein/low-density lipoprotein ratio did not change during therapy. Resumption of menstruation occurred within a mean period of 3 months after the last leuprorelin acetate depot injection.
authors.affiliation: Abteilung für Gynäkologie, Universitätsklinikum Essen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Bühler
authors.forename: U
authors.initials: U
authors.lastname: Winkler
authors.forename: A E
authors.initials: AE
authors.lastname: Schindler
mesh_terms: D015519:Bone Density / Q000187:drug effects; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D016729:Leuprolide / Q000494:pharmacology / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008075:Lipoproteins, HDL / Q000097:blood / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000097:blood / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D011374:Progesterone / Q000097:blood*; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000378:metabolism
chemical_list: D003692:Delayed-Action Preparations; D006065:Gonadotropins, Pituitary; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide