Controlled trial of Haemophilus influenzae type B diphtheria toxoid conjugate combined with diphtheria, tetanus and pertussis vaccines, in 18-month-old children, including comparison of arm versus thigh injection.
A randomized, controlled comparison was made in 175 healthy 18-month-old children given either diphtheria and tetanus toxoids and pertussis vaccine, adsorbed (DTP) and haemophilus b diphtheria toxoid conjugate vaccine (PRP/D) concurrently at separate sites (66 children) or a new vaccine combining these products (109 children). Rates of local or systemic adverse effects postimmunization and antibody responses to each component did not differ significantly between groups. DTP-containing vaccines were better tolerated when given in the thigh than in the arm. The combination DTP-PRP/D vaccine performed satisfactorily at 18 months of age, avoiding the inconvenience of two injections.
Scheifele
D
D
Vaccine Evaluation Center, University of British Columbia, Vancouver, Canada.
Bjornson
G
G
Barreto
L
L
Meekison
W
W
Guasparini
R
R
D001132:Arm; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage*; D018073:Haemophilus Vaccines; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D007866:Leg; D014611:Vaccination / Q000379:methods
D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C052180:Haemophilus influenzae type b-polysaccharide vaccine-diphtheria toxoid conjugate