title: Dynamic training and circulating neuropeptides in rheumatoid arthritis: a two-year follow-up study.
abstract: Previous research has suggested that a short-term (6 week) high-intensity and a subsequent long-term (1 year) low-intensity dynamic training programme in 8 patients with rheumatoid arthritis (RA) increased circulating levels of beta-endorphin (beta-EP) during the high-intensity training and of corticotropin-releasing factor (CRF) and beta-lipotropin (beta-LPH) levels during the low-intensity training, without an increase of pain experience. The present follow-up study of the patients, using the data obtained after an additional 1-year period of no standardized training as reference values, indicated that CRF levels decreased significantly (P less than 0.01) in relation to those obtained 1 year earlier. For beta-LPH and beta-EP, no corresponding decreases were noted. No significant difference concerning experience of pain over time was found. High-performance liquid chromatography demonstrated a complex elution pattern with low basal concentration of beta-LPH, which increased after 60 min of training.
authors.affiliation: Health Sciences Centre, Lund University, S-240 10 DalbySweden Department of Psychiatry and Neurochemistry, Lund University, S-220 06 LundSweden Rheumatology Section, Department of Medicine, Nya Lasarettet, S-251 87 HelsingborgSweden.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Ekdahl
authors.forename: Sven Ingmar
authors.initials: SI
authors.lastname: Andersson
authors.forename: Rolf
authors.initials: R
authors.lastname: Ekman
authors.forename: Björn
authors.initials: B
authors.lastname: Svensson
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000503:physiopathology; D003346:Corticotropin-Releasing Hormone / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D010806:Physical Education and Training; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood*; D008083:beta-Lipotropin / Q000097:blood*
chemical_list: D001615:beta-Endorphin; D003346:Corticotropin-Releasing Hormone; D008083:beta-Lipotropin