title: [Thrombolytic therapy of myocardial infarction. Prognostic value of early reduction of elevation of ST segment].
abstract: In-hospital mortality, infarction mass (estimated enzymatically) and electrocardiographic indexes (total ST-segments elevation, number of leads with R-wave presence and total R-waves amplitude) were assessed in 532 patients with acute myocardial infarction, randomized to two treatment groups: 272 treated with streptokinase (SK) and 260 with heparin (H). Echocardiographic contractility indexes (contractility disturbances area index, contractility disturbances index, left ventricle diastolic diameter) and heart volume estimated from X-ray film were also assessed. There were no significant differences in mortality and infarction area between the two groups. In 175 patients total ST-segments elevation was reduced by at least 50%, in the rest 340 patients this reduction was less significant. In the group with early elevated ST-segment reduction there were less in-hospital deaths (p less than 0.01), smaller infarction mass (p less than 0.0001) and significantly less disturbed electrocardiographic contractility indexes. Results suggest that simple electrocardiographic index, namely reduction of ST-segment elevation by 50% after 2 hours of treatment may be a useful prognostic tool, independent on treatment options, as far as in-hospital mortality, necrosis mass and left ventricle contractility disturbances are concerned.
authors.affiliation: Kliniki Choroby Wieńcowej Instytutu Kardiologii, Warszawie.
authors.forename: Z
authors.initials: Z
authors.lastname: Sadowski
authors.forename: E
authors.initials: E
authors.lastname: Pietrzyk
authors.forename: K
authors.initials: K
authors.lastname: Baraniewski
authors.forename: I
authors.initials: I
authors.lastname: Piszczek
authors.forename: W
authors.initials: W
authors.lastname: Proniewsa
authors.forename: G
authors.initials: G
authors.lastname: Swiatecka
authors.forename: O
authors.initials: O
authors.lastname: Sczaniecka
authors.forename: A
authors.initials: A
authors.lastname: Curyło
authors.forename: E
authors.initials: E
authors.lastname: Dziduszko-Fedorko
authors.forename: M
authors.initials: M
authors.lastname: Prasał
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013997:Time Factors
chemical_list: D006493:Heparin; D013300:Streptokinase
vernacular_title: Zawał serca leczony trombolitycznie. Znaczenie rokownicze wczesnej redukcji uniesienia odcinka ST.