[Clebopride in premedication in ambulatory interventions in general anesthesia].
The authors examine the antiemetic effects of 1 mg clebopride administered iv after surgery, vs a placebo, by making a double blind randomized study on two groups of 40 women comparable by age and weight. The 2 groups of outpatients, admitted for short gynecological surgery, underwent diagnostic uterine curettage. They were anaesthetized with a cocktail of 2.5 mcg/kg fentanyl and 0.25 mg/kg ketamine, on spontaneous respiration. Nausea, vomiting and the other side effects were evaluated 3-6 hours after surgery. Statistically, clebopride proved more effective than placebo against nausea and vomiting (P ranging between 0.05-0.01), with no relevant side effects.
Migliavacca
S
S
Servizio di Anestesia e Rianimazione e Terapia Antalgica, Ospedale Bassini, Cinisello Balsamo, Milano.
Speranza
R
R
Cipolla
M
M
Laveneziana
D
D
D000556:Ambulatory Surgical Procedures; D000768:Anesthesia, General; D000932:Antiemetics / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011229:Preanesthetic Medication
D000932:Antiemetics; D001549:Benzamides; C014417:clebopride
La clebopride nella premedicazione degli interventi ambulatoriali in anestesia generale.