Dimethanesulphonate esters in receptor mapping studies. 2. Antitumour activities of alkyl and alkoxy dimethanesulphonates substituted on a benzene nucleus.
The antitumour activities of 15 novel aromatic dimethanesulphonate esters were studied. Several alkyl and alkoxy compounds have shown good antitumour activity whilst similar isomers have proved ineffective as antitumour agents. These differences in activity have been correlated with the length of the sidechain substituents and their relative flexibilities.
Hadfield
J A
JA
Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital Trust, Withington, Manchester, UK.
Fox
B W
BW
Caffrey
R
R
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001554:Benzene; D015195:Drug Design; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D051381:Rats; D011955:Receptors, Drug; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011955:Receptors, Drug; D008741:Methyl Methanesulfonate; D001554:Benzene