Cocaine and amphetamine facilitate retention of jump-up responding in rats.
The effects of cocaine and d-amphetamine administration on the acquisition of an automated jump-up active avoidance task were examined in two separate experiments. On days 1 and 2, male Sprague-Dawley rats received one escape-only training trial, followed immediately by the intraperitoneal injection of cocaine, amphetamine, or saline. On day 3, subjects received eight escape/avoidance trials. The posttraining administration of cocaine (2.75 and 5.55 mg/kg) and amphetamine (0.3 and 1.0 mg/kg) on days 1 and 2 facilitated jump-up avoidance performance on day 3. Importantly, both cocaine and amphetamine enhanced learning and memory under experimental conditions that allowed for drug-free training and testing.
Janak
P H
PH
Department of Psychology, University of California, Berkeley 94720.
Martinez
J L
JL
D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000661:Amphetamine; D003042:Cocaine