[Experimental liver metastases of human colonic cancer: correlation with degree of differentiation and CEA production].
The influence of cellular differentiation and CEA-production by colorectal tumor cells on experimental hepatic metastases was studied. Eight human colon cancer cell lines were injected into the spleen of athymic mice. The four poorly differentiated, non or low CEA producing cell lines were poorly metastatic to the liver. In contrast, the four well-differentiated cell lines which produce moderate to high levels of CEA were highly metastatic. We conclude in this animal model that poorly differentiated, non or low CEA producing colorectal cell lines have a lower metastatic potential compared to the well-differentiated, high CEA producing tumor cells.
Wagner
H E
HE
Klinik für Viszerale und Transplantationschirurgie, Inselspital Bern.
Steele
G D
GD
Thomas
P
P
D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002455:Cell Division / Q000502:physiology*; D002460:Cell Line; D015179:Colorectal Neoplasms / Q000473:pathology*; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured / Q000473:pathology*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen
Experimentelle Lebermetastasen von menschlichen Kolonkarzinomen: Korrelation mit Differenzierungsgrad und CEA-Produktion.