Modifications of "A cells" in the development of experimentally induced pancreatic ductal adenocarcinoma: an ultrastructural and immunohistochemical study.
In the hamster-BOP model, modifications occur in the endocrine portion of the pancreas during the induction of well-differentiated ductal carcinomas. In the present work, using immunohistochemical techniques it was possible to observe that the A cells in preserved islets and in the initial phase of the carcinogenic process were localized in the peripheral part of the islets. In animals with tumours, A cells were found to form part of the tumour glands and/or the tumoral stroma; this localization was seen to depend on the developmental phase of the tumour. A focal dispersion of A cells was observed in the animals with ductal carcinoma.
Abad
M M
MM
Department of Pathology, University Hospital, Salamanca, Spain.
Paz-Bouza
J I
JI
Arévalo
M
M
Muñoz
E
E
Carrascal
E
E
Bullón
A
A
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology* / Q000648:ultrastructure; D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D005260:Female; D007515:Islets of Langerhans / Q000473:pathology*; D008647:Mesocricetus; D008854:Microscopy, Electron; D009602:Nitrosamines; D010190:Pancreatic Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000648:ultrastructure
D002273:Carcinogens; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine