Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids.
The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylhepatanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis. This was verified by testing their inhibitory effects on 5-lipoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.
Kiuchi
F
F
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Iwakami
S
S
Shibuya
M
M
Hanaoka
F
F
Sankawa
U
U
D002396:Catechols; D002460:Cell Line; D016861:Cyclooxygenase Inhibitors; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006536:Heptanes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007124:Immunoenzyme Techniques; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015289:Leukotrienes / Q000096:biosynthesis*; D016859:Lipoxygenase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal; D011453:Prostaglandins / Q000096:biosynthesis*
D002396:Catechols; D016861:Cyclooxygenase Inhibitors; D005233:Fatty Alcohols; D006536:Heptanes; D007659:Ketones; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D011453:Prostaglandins; C007845:gingerol