title: Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone.
abstract: Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone indicating a possible feedback type of action.
authors.affiliation: Department of Biochemistry, Indian Institute of Science, Bangalore.
authors.forename: R V
authors.initials: RV
authors.lastname: Omkumar
authors.forename: A S
authors.initials: AS
authors.lastname: Gaikwad
authors.forename: T
authors.initials: T
authors.lastname: Ramasarma
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D005246:Feedback; D006903:Hydroxymethylglutaryl CoA Reductases / Q000302:isolation & purification; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D014451:Ubiquinone / Q000494:pharmacology*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D014451:Ubiquinone; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases