title: Intracystic papillary carcinoma of the male breast. A case report (histochemical, immunohistochemical and ultrastructural study).
abstract: We report a case of intracystic papillary carcinoma of the male breast in a 70-year-old male Caucasian. Grossly, the tumor was a cystic lesion measuring 6 cm in diameter. It contained hemorrhagic fluid and a mural nodule with filiform projections. PAS stain with and without digestion revealed small clumps of diastase-resistant material in the cytoplasm of the neoplastic cells. Grimelius stain was positive. Immunoperoxidase stains were negative for neuron-specific enolase, S100 protein, cromogranin and synaptophysin and were positive for carcinoembryonic antigen and epithelial membrane antigen. On ultrastructural examination the neoplastic cells showed membrane-bound, dense-core secretory granules. We believe that this neoplasm, despite negative neuroendocrine markers, is a variant of mammary adenocarcinoma with endocrine differentiation, partly because of the positive Grimelius stain and partly because of the presence of electron-dense granules, which according to some authors represent lactational differentiation.
authors.affiliation: Institute of Pathology, II Faculty of Medicine and Surgery, University of Naples Federico II, Italy.
authors.forename: G
authors.initials: G
authors.lastname: De Rosa
authors.forename: G
authors.initials: G
authors.lastname: Giordano
authors.forename: A
authors.initials: A
authors.lastname: Boscaino
authors.forename: L
authors.initials: L
authors.lastname: Terracciano
authors.forename: V
authors.initials: V
authors.lastname: Donofrio
authors.forename: G
authors.initials: G
authors.lastname: De Dominicis
mesh_terms: D000368:Aged; D001706:Biopsy; D001940:Breast / Q000378:metabolism / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D002291:Carcinoma, Papillary / Q000378:metabolism* / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron