title: Hepatobiliary enhancement with Gd-EOB-DTPA: comparison of spin-echo and STIR imaging for detection of experimental liver metastases.
abstract: Gadolinium (4S)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecandioic acid-disodium salt (EOB-DTPA) ethoxybenzyl is a new hepatobiliary magnetic resonance (MR) contrast agent with dual elimination: 75% through the liver and bile and 25% through the kidneys in normal rats. In this study, Gd-EOB-DTPA was evaluated in a rodent model of metastatic liver disease to measure both relative enhancement and lesion-to-liver contrast. A secondary goal was to compare the relative performance of spin-echo (SE) and short inversion time inversion-recovery (STIR) imaging to demonstrate enhancement with Gd-EOB-DTPA. After administration of 0.1 mmol of Gd-EOB-DTPA per kilogram, liver signal increased (positive enhancement) more than 200% with the use of the SE technique and declined (negative enhancement) by more than 80% with use of the STIR technique. Only minimal enhancement of implanted liver tumor was observed. Unlike the tumor, the gall-bladder and lumen of the duodenum were progressively enhanced over time. The lesion-to-liver contrast increased by approximately 500% with both the SE and STIR techniques after administration of Gd-EOB-DTPA.
authors.affiliation: Department of Radiology, University of California San Francisco 94143-0628.
authors.forename: A
authors.initials: A
authors.lastname: Mühler
authors.forename: O
authors.initials: O
authors.lastname: Clément
authors.forename: V
authors.initials: V
authors.lastname: Vexler
authors.forename: Y
authors.initials: Y
authors.lastname: Berthezène
authors.forename: W
authors.initials: W
authors.lastname: Rosenau
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
mesh_terms: D000085:Acetates; D000818:Animals; D001646:Bile; D003287:Contrast Media; D004386:Duodenum; D004492:Edetic Acid / Q000031:analogs & derivatives; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D005704:Gallbladder; D008099:Liver; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D051379:Mice; D015233:Models, Statistical; D009942:Organometallic Compounds; D004369:Pentetic Acid; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives; D051381:Rats; D013997:Time Factors
chemical_list: D000085:Acetates; D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; C064572:gadobenic acid; D011732:Pyridoxal Phosphate; D008536:Meglumine; D004369:Pentetic Acid; D004492:Edetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA; C060076:N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid