Safety study of a beef-based chewable tablet formulation of ivermectin and pyrantel pamoate in growing dogs, pups, and breeding adult dogs.
To determine the safety of a new combination of ivermectin and pyrantel (as pamoate salt) in a novel beef-based chewable tablet formulation, 3 tolerance trials were conducted and included growing dogs, pups, and breeding adult dogs. Growing dogs, given the combination orally for 5 consecutive days at recommended dosages (5 mg of pyrantel/kg of body weight, 6 micrograms of ivermectin/kg) or at twice the pyrantel dosage in combination with the recommended dosage of ivermectin, had no adverse effects. The combination also was administered to 6-week-old pups at 1, 3, and 5 times the recommended dose on 3 successive days for 3 times in 1 month. Compared with age-matched controls, treatment had no effect on clinical status, growth rate, or gross or histologic features. Breeding male and female dogs given the combination at 3 times the recommended dose for extended periods had no adverse effects, and prevalence of abnormalities in the offspring was not greater than that in nonmedicated controls.
Clark
J N
JN
Merck, Sharp & Dohme Research Laboratories, Division of Merck & Co Inc, Rahway, NJ 07065-0900.
Pulliam
J D
JD
Daurio
C P
CP
D000014:Abnormalities, Drug-Induced / Q000662:veterinary; D000284:Administration, Oral; D000818:Animals; D004184:Dirofilariasis / Q000517:prevention & control / Q000662:veterinary*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D004338:Drug Combinations; D004361:Drug Tolerance; D005260:Female; D005298:Fertility / Q000187:drug effects; D005306:Fertilization / Q000187:drug effects; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008098:Litter Size / Q000187:drug effects; D008297:Male; D011716:Pyrantel Pamoate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011897:Random Allocation; D012098:Reproduction / Q000187:drug effects; D013607:Tablets
D004338:Drug Combinations; D013607:Tablets; D007559:Ivermectin; D011716:Pyrantel Pamoate