title: Safety, tolerance and pharmacokinetics of cefpirome administered intramuscularly to healthy subjects.
abstract: The pharmacokinetics of cefpirome were studied in healthy male subjects following single (0.5, 1.0 and 2.0 g) and multiple (1.0 g every 12 h for 3.5 days) intramuscular injections. High pressure liquid chromatography was used to determine cefpirome concentrations in plasma and urine. Cefpirome was absorbed rapidly, mean peak times were 1.6-2.3 h. Pharmacokinetics were linear over the 0.5 to 2.0 g range with mean total body clearance ranging from 148 to 154 mL/min. The peak plasma concentration and area under the curve increased in a dose proportional manner. The terminal half-life (2 h) was not influenced by dose or duration of dosing. There was no drug accumulation after multiple in administrations. About 70-80% of an administered dose was excreted in the urine as unchanged cefpirome. Cefpirome was well tolerated, slight to moderate pain being reported in less than 30% of the injections.
authors.affiliation: Department of Pharmacology, University of the Orange Free State, Bloemfontein, Republic of South Africa.
authors.forename: B H
authors.initials: BH
authors.lastname: Meyer
authors.forename: F O
authors.initials: FO
authors.lastname: Muller
authors.forename: H G
authors.initials: HG
authors.lastname: Luus
authors.forename: B
authors.initials: B
authors.lastname: Drees
authors.forename: H J
authors.initials: HJ
authors.lastname: Röthig
authors.forename: M
authors.initials: M
authors.lastname: Badian
authors.forename: H G
authors.initials: HG
authors.lastname: Eckert
mesh_terms: D000328:Adult; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D000097572:Cefpirome
chemical_list: D002511:Cephalosporins; D000097572:Cefpirome