Pharmacokinetics of cefpirome administered intravenously or intramuscularly to rats and dogs.
The pharmacokinetic profile of cefpirome was evaluated in rats and dogs after a single intravenous or intramuscular dose. A two-compartment open model was used for the calculation of the pharmacokinetic parameters for both routes of administration. The elimination half-lives after intravenous and intramuscular administration of 20 mg/kg cefpirome did not differ significantly and ranged from 0.4 h in rats to 1.1 h in dogs. Cefpirome was mainly excreted via the kidneys. After iv or im dosing of the compound, between 80% (dogs) and 90% (rats) was recovered in urine within 24 h. The bioavailability of cefpirome in rats and dogs after both routes of administration was almost identical when calculated either by the AUC or the urinary recovery rates.
Isert
D
D
Hoechst AG, SBU Antiinfectives Research, Frankfurt, Germany.
Klesel
N
N
Limbert
M
M
Markus
A
A
Seibert
G
G
Schrinner
E
E
D000818:Animals; D001682:Biological Availability; D002511:Cephalosporins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome