title: Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate.
abstract: Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmacokinetic profile and thermogenic effect during a short-time infusion (5 h at 10 g/h) in 7 male volunteers. Sebacate in serum and urine was measured by high-performance liquid chromatography. A single-compartment model with two linear elimination routes was fitted. Metabolic measurements (VO2, VCO2, respiratory quotient, metabolic rate) were continuously performed for 8 h (5 h during and 3 h after the infusion) by a canopy indirect calorimeter. The apparent volume of distribution of sebacate was 8.39 +/- 0.69 liters, and the plasma fractional removal rate constant was 0.0086 +/- 0.00077 min-1. The average half-life and plasma clearance were 80.6 min and 72 ml/min, respectively. The increase in metabolic rate, the decrease in respiratory quotient and the changes in ketone body, glucagon and insulin levels during the infusion were not significant. 24-hour catecholamine excretion was within normal limits. Calories administered by sebacate seem to be available for utilization without relevant metabolic side effects.
authors.affiliation: Istituto di Clinica Medica, CNR Centro Studio Fisiopathologia Shock, Università Cattolica del Sacro Cuore, Roma, Italia.
authors.forename: A V
authors.initials: AV
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Mingrone
authors.forename: C
authors.initials: C
authors.lastname: Raguso
authors.forename: A
authors.initials: A
authors.lastname: Tataranni
authors.forename: E
authors.initials: E
authors.lastname: Finotti
authors.forename: R M
authors.initials: RM
authors.lastname: Tacchino
authors.forename: E
authors.initials: E
authors.lastname: Capristo
authors.forename: A
authors.initials: A
authors.lastname: De Gaetano
authors.forename: M
authors.initials: M
authors.lastname: Castagneto
mesh_terms: D000328:Adult; D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D003652:Decanoic Acids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003998:Dicarboxylic Acids / Q000097:blood / Q000652:urine; D004734:Energy Metabolism; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009765:Obesity / Q000378:metabolism
chemical_list: D003652:Decanoic Acids; D003998:Dicarboxylic Acids; C011107:sebacic acid