title: Lower limb arterio-venous shunts, autonomic neuropathy and diabetic foot.
abstract: We have quantitatively assessed the percentage of lower limb arterio-venous (a-v) shunting using a radioisotopic technique and correlated it with autonomic neuropathy evaluated by cardiovascular tests. We have studied three groups of diabetic patients: Group A, 12 non-neuropathic subjects without foot lesions; Group B, 12 neuropathic subjects without foot lesions; Group C, 12 neuropathic subjects with recurrent foot ulcers. Shunting was higher in Group C (10.4 +/- 2.7%) than in Group B (6.8 +/- 2.3%, P less than 0.01) and Group A (3.8 +/- 1.2%, P less than 0.001). Shunts in Group B were higher than in Group A (P less than 0.05). All the tests exploring autonomic function were more impaired in Groups B and C than in Group A, with no difference between Groups B and C. A direct correlation was found between a-v shunting and the following cardiovascular tests: postural hypotension (PH) (r = 0.41, P less than 0.02), sustained handgrip (SH) (r = 0.56, P less than 0.001), deep breathing (DB) (r = 0.40, P less than 0.005) and lying to standing (LS) (r = 0.44, P less than 0.01). A positive correlation was also found between a-v shunts and duration of the disease (r = 0.62, P less than 0.001). Arterio-venous shunting was found to be directly related to autonomic neuropathy even if the higher shunting found in the patients with foot ulcers was not related to a higher degree of autonomic involvement; in addition, this group of patients was characterized by having a more advanced sensory and motor neuropathy. In conclusion, autonomic neuropathy, through its influence on a-v shunts, may play a role in the pathogenesis of diabetic foot, but peripheral neuropathy probably plays a key role in conditioning the development of the overt clinical manifestations of diabetic foot.
authors.affiliation: Cattedra di Malattie del Ricambio, II Univ. Roma Tor Vergata, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Uccioli
authors.forename: L
authors.initials: L
authors.lastname: Mancini
authors.forename: A
authors.initials: A
authors.lastname: Giordano
authors.forename: A
authors.initials: A
authors.lastname: Solini
authors.forename: P
authors.initials: P
authors.lastname: Magnani
authors.forename: A
authors.initials: A
authors.lastname: Manto
authors.forename: P
authors.initials: P
authors.lastname: Cotroneo
authors.forename: A V
authors.initials: AV
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Ghirlanda
mesh_terms: D000419:Albuminuria; D001158:Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology; D005528:Foot / Q000098:blood supply; D016523:Foot Ulcer / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009431:Neural Conduction; D010543:Peroneal Nerve / Q000503:physiopathology; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D013497:Sural Nerve / Q000503:physiopathology; D014680:Veins / Q000000981:diagnostic imaging / Q000503:physiopathology*