title: In vitro activities of chloroquine in combination with chlorpromazine or prochlorperazine against isolates of Plasmodium falciparum.
abstract: The combinations of chloroquine plus chlorpromazine and chloroquine plus prochlorperazine were evaluated in vitro for potentiation against isolates of Plasmodium falciparum. Potentiation was observed against all chloroquine-resistant isolates. There was no potentiation against 8 of 10 chloroquine-susceptible isolates. The results indicated that the phenothiazines can potentiate chloroquine action against resistant parasites found in natural conditions.
authors.affiliation: Centre National de Référence pour la Chimiosensibilité du Paludisme, Hôpital Bichat-Claude Bernard, Paris, France.
authors.forename: L K
authors.initials: LK
authors.lastname: Basco
authors.forename: J
authors.initials: J
authors.lastname: Le Bras
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000302:isolation & purification; D011346:Prochlorperazine / Q000494:pharmacology*
chemical_list: D002738:Chloroquine; D002746:Chlorpromazine; D011346:Prochlorperazine