Pulmonary sequelae of intraparenchymal bismuth subgallate.
Bismuth subgallate (BSG) is a heavy metal compound which is effective in lowering the incidence of hemorrhage after adenotonsillectomy and has been demonstrated to activate Factor XII. In a minority of children, the paste has been suctioned from the cuffless oral endotracheal tube after adenotonsillectomy. No pulmonary sequelae have been noted in these patients. To assess the effect of BSG aspiration, 75 rats were divided into groups receiving either intratracheal BSG or saline. Early and late parenchymal effects were documented at 5 and 30 days following administration. Although there were no differences in the general well-being, activity level, or weight in these rats, acute pneumonia followed by a histiocytic, foreign-body response was noted in a significant number of rats in the BSG group. Although no clinical pulmonary sequelae of BSG use have been noted in our patients, this information should alert clinicians to the risks of BSG use in the pulmonary-compromised patient, and encourage them to either employ all methods of preventing aspiration in such patients when using BSG, or to use another hemostatic modality for the utmost safety.
Cozzi
L M
LM
Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, University Hospitals of Cleveland, OH.
Megerian
C A
CA
Dugue
C
C
Barcello
M
M
Abdul-Karim
F W
FW
Arnold
J E
JE
Maniglia
A J
AJ
D000818:Animals; D001729:Bismuth / Q000009:adverse effects*; D003593:Cytoplasm / Q000648:ultrastructure; D005549:Foreign-Body Reaction / Q000139:chemically induced / Q000473:pathology; D005707:Gallic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D006490:Hemostatics / Q000009:adverse effects*; D006644:Histiocytes / Q000473:pathology; D001239:Inhalation; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology; D009942:Organometallic Compounds / Q000009:adverse effects*; D011015:Pneumonia, Aspiration / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D006490:Hemostatics; D009942:Organometallic Compounds; D005707:Gallic Acid; D001729:Bismuth; C002170:bismuth subgallate