Experimental focal cerebral ischaemia assessed with IVIM*-MRI in the acute phase at 0.5 tesla.
Intravoxel incoherent motion (IVIM*)-MRI has been performed on a clinical system at 0.5 tesla with a b gradient factor of 100 s/mm2, in a feline focal model of cerebral ischaemia. Images were obtained in 26 cats from less than 1 hour and up to 7-12 hours after stroke. The apparent diffusion coefficient (ADC) was decreased at the site of injury when compared to the contralateral normal side, by 30% in the first, 33% in 1-2 h and 27% in 2-4 h; it increased at 7-12 h, when vasogenic oedema occurred. IVIM*-MRI demonstrated early changes, due to cytotoxic oedema, during the acute phase of cerebral ischaemia to which conventional T2-weighted spin-echo imaging was not sensitive.
Berry
I
I
Neuroradiology and MRI unit, CHU Purpan, Toulouse, France.
Gigaud
M
M
Manelfe
C
C
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000175:diagnosis / Q000503:physiopathology; D002545:Brain Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D002415:Cats; D002544:Cerebral Infarction / Q000175:diagnosis / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004058:Diffusion; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*