title: The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7.
abstract: Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation.
authors.affiliation: Department of Pharmacology, University of California-San Diego, La Jolla 92093-0636.
authors.forename: D K
authors.initials: DK
authors.lastname: Getman
authors.forename: J H
authors.initials: JH
authors.lastname: Eubanks
authors.forename: S
authors.initials: S
authors.lastname: Camp
authors.forename: G A
authors.initials: GA
authors.lastname: Evans
authors.forename: P
authors.initials: P
authors.lastname: Taylor
mesh_terms: D000110:Acetylcholinesterase / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D008856:Microscopy, Fluorescence; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction
chemical_list: D000110:Acetylcholinesterase