Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia.
The cathepsin B, D and L were studied by immunohistochemical techniques in the human postmortem brain. The enzyme were primarily localized in neurons. Makroglial cells were seldom immunostained. It is shown that cathepsins B and D frequently occur in neuritic plaques of Alzheimer victims, thereby raising the question, whether or not cathepsin immunohistochemistry is a useful tool in the diagnosis of this disease. Furthermore, we identified certain glial cells to be immunoreactive for cathepsins in schizophrenics.
Bernstein
H G
HG
Institute of Neurobiology and Brain Research Magdeburg, Martin-Luther-University Halle, Wittenberg, Germany.
Kirschke
H
H
Wiederanders
B
B
Khudoerkov
R M
RM
Hinz
W
W
Rinne
A
A
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000201:enzymology; D001253:Astrocytes / Q000201:enzymology; D002401:Cathepsin B / Q000032:analysis*; D002402:Cathepsin D / Q000032:analysis*; D056668:Cathepsin L; D002403:Cathepsins / Q000032:analysis*; D002540:Cerebral Cortex / Q000201:enzymology / Q000473:pathology; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016501:Neurites / Q000201:enzymology; D009457:Neuroglia / Q000201:enzymology; D012559:Schizophrenia / Q000175:diagnosis* / Q000201:enzymology
D002403:Cathepsins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; C534281:CTSL protein, human; D056668:Cathepsin L; D002402:Cathepsin D