Glomerular capsular herniation in focal glomerular sclerosis.
Renal biopsy from a patient with focal segmental sclerosing glomerulopathy (FSSG) and nephrotic syndrome showed localized rupture of Bowman's capsule with herniation of a glomerular loop into the adjacent periglomerular connective tissue. Another glomerulus contained similar changes. Glomerular capsular herniation may be frequent, but unrecognized, in FSSG and would explain many of the morphological features seen in both primary and secondary forms.
Panner
B J
BJ
Department of Pathology, School of Medicine and Dentistry, University of Rochester, NY.
Berkowitz
P
P
D000328:Adult; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D012422:Rupture, Spontaneous