title: Dietary effects of allopurinol and sulfinpyrazone on development, survival, and reproduction of German cockroaches (Dictyoptera: Blattellidae).
abstract: Diets containing two gout medications, allopurinol and sulfinpyrazone, were fed ad libitum to first- or second-instar German cockroaches for 15 wk or until 100% mortality was reached. Cockroaches fed greater than or equal to 0.10% allopurinol diets weighed significantly less than those fed the control diet. Mortality of cockroaches fed diets containing greater than or equal to 0.05% allopurinol was significantly greater than those fed the control diet. The LT50 (6.1 wk) of cockroaches fed diets containing 0.10% allopurinol was significantly less than those fed any other diet containing allopurinol. LT50s and slopes were proportional and inversely related, respectively, to percentage of allopurinol in the diet. The addition of sulfinpyrazone to allopurinol diets minimally enhanced the blatticidal nature of the diets. Nymphs fed diets containing greater than or equal to 0.05% allopurinol experienced significant delays in adult emergence. Cockroaches fed greater than or equal to 0.01% allopurinol diets aborted a significantly greater percentage of their oothecae than those fed the 0.001% allopurinol or control diets. Hatched oothecae from cockroaches fed the 0.01% allopurinol diet had significantly fewer nymphs than those fed the 0.001% allopurinol or control diets. Percentage of oothecae aborted and number of nymphs per hatched ootheca from cockroaches fed a 2% sulfinpyrazone diet did not differ significantly from the control.
authors.affiliation: Department of Entomology and Nematology, University of Florida, Gainesville 32611.
authors.forename: D R
authors.initials: DR
authors.lastname: Suiter
authors.forename: P C
authors.initials: PC
authors.lastname: Koehler
authors.forename: R S
authors.initials: RS
authors.lastname: Patterson
mesh_terms: D000493:Allopurinol; D000818:Animals; D003058:Cockroaches / Q000254:growth & development / Q000502:physiology; D005260:Female; D009758:Nymph; D012098:Reproduction / Q000187:drug effects; D013442:Sulfinpyrazone
chemical_list: D000493:Allopurinol; D013442:Sulfinpyrazone