Modulation of humoral and cellular resistance in children with laryngeal papillomatosis.
As accessory cells in immunity response immunoglobulin and lymphocytes participate in antitumor immunity. Quantitative changes in concentrations and numbers were studied once before therapy, without examining the functional state. In order to gain more information on the humoral response during and after treatment, and in cases of recurrence, bactericidal antibodies against B. anthracis were determined by means of 51Cr-labeled microbes. The results of the present study show that IgG levels were normal and IgA and IgM normal or increased. In only 2 children (0.8%) the levels of serum IgM were lowered. Although a high percentage of increased trend values of bactericidity in cured children was found (75%), the percentage in children with recurrences reaching 50%, the differences are considered statistically insignificant. Following T lymphocyte, figures a significant decrease in juvenile laryngeal papillomatosis (JLP) patients were found.
Jakubíková
J
J
Pediatric Otolaryngologic Clinic, Faculty of Medicine, Comenius University, Bratislava Czechoslovakia.
Oravec
C
C
Klacanský
I
I
D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D001408:Bacillus anthracis / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007822:Laryngeal Neoplasms / Q000097:blood / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D010212:Papilloma / Q000097:blood / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D000907:Antibodies, Bacterial; D007136:Immunoglobulins