title: Human casein kinase II subunit alpha: sequence of a processed (pseudo)gene and its localization on chromosome 11.
abstract: A human 4.3 kb genomic DNA fragment, containing the information of a processed (pseudo)gene of casein kinase II subunit alpha (CKII alpha) was isolated and sequenced. The genomic CKII alpha sequence is 99% homologous to the CKII alpha cDNA, carries several nucleotide exchanges, a poly(A) stretch at its 3' end and is flanked at both ends by a 16 bp repeat. It has a promoter-like region including two TATA boxes and a CAAT box. Although translation of transcripts would be terminated by a stop codon after two third of the coding region, the resulting protein would still contain the catalytic domains. However, so far Northern blots with a 3' specific probe were negative. The 4.3 kb genomic fragment containing the processed CKII alpha (pseudo)gene was mapped by in situ hybridization to chromosome 11p15.
authors.affiliation: German Cancer Research Center, Heidelberg.
authors.forename: U
authors.initials: U
authors.lastname: Wirkner
authors.forename: H
authors.initials: H
authors.lastname: Voss
authors.forename: P
authors.initials: P
authors.lastname: Lichter
authors.forename: S
authors.initials: S
authors.lastname: Weitz
authors.forename: W
authors.initials: W
authors.lastname: Ansorge
authors.forename: W
authors.initials: W
authors.lastname: Pyerin
mesh_terms: D001483:Base Sequence; D047390:Casein Kinase II; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004247:DNA; D006801:Humans; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D011544:Pseudogenes
chemical_list: D004247:DNA; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases