A common viral infection can change nickel target organ distribution.
The autoradiographic distribution of the toxic heavy metal nickel (Ni) was studied at 4 and 7 days post-coxsackievirus B3 (CB3) infection in Balb/c mice. The distribution of the iv injected 63Ni was studied 10 min, 4 hr, and 24 hr after administration. Results clearly show that the site of 63Ni accumulation is greatly changed during this viral infection. This newly discovered distribution was mainly visible as a greatly increased accumulation in the pancreas and the wall of the ventricular myocardium. Healthy animals showed almost no 63Ni accumulation in these tissues. These results for the first time show that an invading microorganism can change the distribution of an environmental pollutant.
Ilbäck
N G
NG
Toxicology Laboratory, National Food Administration, Uppsala, Sweden.
Fohlman
J
J
Friman
G
G
D000818:Animals; D001345:Autoradiography; D003384:Coxsackievirus Infections / Q000378:metabolism*; D004785:Environmental Pollutants / Q000493:pharmacokinetics; D006352:Heart Ventricles / Q000378:metabolism; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D009532:Nickel / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010179:Pancreas / Q000378:metabolism; D014018:Tissue Distribution
D004785:Environmental Pollutants; C022838:nickel chloride; D009532:Nickel