title: Giant cell tumor of bone treated by curettage, cementation, and bone grafting.
abstract: Giant cell tumor, a relatively rare, occasionally malignant tumor of bone, remains a difficult therapeutic problem for the orthopedic surgeon. Various treatment options, including curettage alone, curettage with bone grafting, radiation, and curettage with acrylic cementation have been utilized and reported. Therapeutic complications such as infection, recurrence, and loss of support of the articular surface have continued to plague the treatment of giant cell tumors. This article reports the results of 10 consecutive cases of giant cell tumor of bone treated by curettage and methyl methacrylate cementation, followed by bone grafting of the surface of the lesion with demineralized bone matrix to reconstitute the cortex at the site of the tumor. At an average follow up of 36 months, eight patients had an excellent functional result and two had a fair result as scored on the Musculoskeletal Tumor Society rating system. To date, there have been no tumor recurrences or metastases, and all patients have radiographic evidence of healing of the weight bearing cortical surface.
authors.affiliation: Department of Surgery, Fitzsimons Army Medical Center, Aurora, Colo.
authors.forename: S D
authors.initials: SD
authors.lastname: Pals
authors.forename: R M
authors.initials: RM
authors.lastname: Wilkins
mesh_terms: D000328:Adult; D001857:Bone Matrix / Q000637:transplantation; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation / Q000379:methods*; D003475:Curettage; D005260:Female; D005500:Follow-Up Studies; D005870:Giant Cell Tumors / Q000601:surgery*; D006801:Humans; D008297:Male; D008768:Methylmethacrylates / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D008768:Methylmethacrylates