title: A lumped parameter mathematical model of the splanchnic circulation.
abstract: A lumped parameter mathematical model to describe the propulsion of blood in the splanchnic circulation was developed by integrating the principles of mechanics and physiology. A set of governing equations by derived by specifically considering the contractility of the portal vein, hepatic vein, liver sinusoids, and of the draining lymphatics. These equations were then simulated on a computer. The present simulation results substantiate previous experimental observations that hepatic venous pressure leads to portal hypertension and increased liver interstitial fluid volume.
authors.affiliation: Department of Biomedical Engineering, University of Akron, Ohio 44325.
authors.forename: T M
authors.initials: TM
authors.lastname: Chu
authors.forename: N P
authors.initials: NP
authors.lastname: Reddy
mesh_terms: D001794:Blood Pressure; D003198:Computer Simulation; D008955:Models, Cardiovascular; D013152:Splanchnic Circulation / Q000502:physiology*; D013314:Stress, Mechanical; D014682:Vena Cava, Inferior / Q000502:physiology