Central facilitation of Ia inhibition during tonic ankle dorsiflexion revealed after blockade of peripheral feedback.
Recent studies have reported that no increase of the disynaptic reciprocal inhibition can be observed during tonic voluntary dorsiflexion of the foot as compared to rest, when the size of the control H-reflex is kept constant. Other studies have, however, shown that a voluntary contraction evokes a strong and long-lasting depression of the synaptic transmission from Ia afferents to motoneurones, most likely secondary to activation of these afferents during the contraction (post-activation depression). It was thought that this effect could also interfere with the demonstration of a central facilitation of the reciprocal inhibition during movement. The amount of disynaptic Ia reciprocal inhibition from the pretibial flexors to the soleus H-reflex was therefore estimated in normal human subjects at rest and during voluntary tonic dorsiflexion before, during and after blocking the peripheral feedback from the investigated muscles. It was observed that the reciprocal inhibition measured during dorsiflexion increased during occlusion of the blood supply to the leg, reaching a maximum of inhibition after 30 min of ischaemia. After release of the ischaemia the inhibition gradually decreased to its pre-ischaemic level. It is therefore suggested that the brain facilitates transmission in the Ia disynaptic reciprocal pathway during tonic voluntary dorsiflexion of the foot, but that this facilitation is normally not observed due to a post-activation depression following the peripheral feedback activation during the movement.
Nielsen
J
J
Institute of Neurophysiology, Panum Institute, University of Copenhagen, Denmark.
Kagamihara
Y
Y
Crone
C
C
Hultborn
H
H
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology*; D000843:Ankle Joint / Q000502:physiology*; D005246:Feedback; D005528:Foot / Q000502:physiology; D006181:H-Reflex / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D007511:Ischemia / Q000503:physiopathology; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply / Q000294:innervation / Q000502:physiology*; D012016:Reference Values; D012039:Regional Blood Flow; D013569:Synapses / Q000502:physiology; D013997:Time Factors