[Apolipoprotein E mobility between plasma lipoproteins in intravenous administration of fat emulsions (MCT, LCT)].
Apolipoprotein (apo) E plays a key role in chylomicron metabolism as a ligand for their uptake via the apo B/E- and apo E receptor into the liver. Apo E is not primarily synthesized with chylomicrons but is postprandially transferred to chylomicrons during lipolysis in plasma from high density lipoproteins (HDL). As triglyceride-/phospholipid emulsions given intravenously acquire apolipoproteins in plasma, we set out to investigate a possible transfer of apo E to these artificial lipoproteins and its role during their further metabolism. To this end healthy normolipemic volunteers and carriers of the frequent apo E3/3 phenotype were infused lipid emulsions. The lipoprotein-distribution of apo E during MCT and LCT infusions was monitored over four hours. Infusion of MCT and LCT resulted in a substantial transfer of apo E from HDL to triglyceride rich lipoproteins. During MCT infusion the transfer of apo E seemed to occur more rapidly than during LCT infusion. This could be one of the reasons for the faster metabolism of MCT over LCT. Plasma levels of apo E also decreased significantly during infusion of triglyceride/phospholipid emulsions in accordance with the role of apo E as a ligand for the uptake of the artificial particles into the liver.
Steinmetz
A
A
Zentrum Innere Medizin, Klinikum, Philipps-Universität Marburg, BRD.
Schwarz
S
S
Richter
G
G
D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics; D002914:Chylomicrons / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D010641:Phenotype; D014280:Triglycerides / Q000008:administration & dosage*
D001057:Apolipoproteins E; D002914:Chylomicrons; D005217:Fat Emulsions, Intravenous; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides
Apolipoprotein E-Mobilität zwischen Plasmalipoproteinen während intravenöser Fettapplikation (MCT, LCT).