Early complement components enhance neutralization of Chlamydia trachomatis infectivity by human sera.
Immunoglobulin G in human serum neutralizes chlamydial infectivity in vitro. Complement-intact, C5-depleted, and C8-depleted human serum all have significantly more neutralizing activity than serum heated to inactivate early components of complement. Cobra venom factor, an analog of human C3b, enhances neutralization of antichlamydial immunoglobulin G in the absence of early complement components.
Lin
J S
JS
Maxwell Finland Laboratory, Boston City Hospital, Massachusetts.
Yan
L L
LL
Ho
Y
Y
Rice
P A
PA
D001770:Blood Bactericidal Activity; D002692:Chlamydia trachomatis / Q000276:immunology* / Q000472:pathogenicity; D003176:Complement C3 / Q000378:metabolism; D003165:Complement System Proteins / Q000502:physiology*; D004546:Elapid Venoms / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology
D003176:Complement C3; D004546:Elapid Venoms; D007074:Immunoglobulin G; C016310:cobra venom factor; D003165:Complement System Proteins