title: A genetic linkage study of schizophrenia to chromosome 5 markers in a northern Italian population.
abstract: Some recent findings report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results: Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigrees segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.
authors.affiliation: Istituto Scientifico H San Raffaele, Clinical Psychiatry 3rd, Milan University School of Medicine, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: L
authors.initials: L
authors.lastname: Ruocco
authors.forename: L
authors.initials: L
authors.lastname: Giuffra
authors.forename: P
authors.initials: P
authors.lastname: Carrera
authors.forename: C
authors.initials: C
authors.lastname: Marino
authors.forename: V
authors.initials: V
authors.lastname: Rinaldi
authors.forename: E
authors.initials: E
authors.lastname: Smeraldi
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
mesh_terms: D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D007558:Italy; D010375:Pedigree; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
chemical_list: D005819:Genetic Markers