title: Occurrence of (E)-4-hydroxy-2-nonenal in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis.
abstract: (E)-4-Hydroxy-2-nonenal (HNE), a cytotoxic propagation product of lipid peroxidation, is present in the synovial fluid (0.54 (0.19) mumol/l; mean (SE), n = 9) and plasma (0.34 (0.09) mumol/l, n = 9) of patients with rheumatoid arthritis. This compound was also found in the synovial fluid (0.24 (0.19) mumol/l, n = 9) and plasma (0.09 (0.03) mumol/l, n = 9) of patients with osteoarthritis. The concentration of HNE in the plasma of patients with rheumatoid arthritis was significantly greater than in patients with osteoarthritis.
authors.affiliation: Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Royal Canberra Hospital, Garran, ACT.
authors.forename: M L
authors.initials: ML
authors.lastname: Selley
authors.forename: D J
authors.initials: DJ
authors.lastname: Bourne
authors.forename: M R
authors.initials: MR
authors.lastname: Bartlett
authors.forename: K E
authors.initials: KE
authors.lastname: Tymms
authors.forename: A S
authors.initials: AS
authors.lastname: Brook
authors.forename: A M
authors.initials: AM
authors.lastname: Duffield
authors.forename: N G
authors.initials: NG
authors.lastname: Ardlie
mesh_terms: D000447:Aldehydes / Q000032:analysis* / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D010003:Osteoarthritis / Q000378:metabolism*; D013582:Synovial Fluid / Q000737:chemistry*
chemical_list: D000447:Aldehydes; C027576:4-hydroxy-2-nonenal