Effects of administration of murine recombinant IL-4 on the resistance of mice to Listeria monocytogenes infection.
Mice given recombinant murine interleukin-4 as a single i.v. bolus concomitant with a Listeria monocytogenes challenge did not display increased anti-listeria resistance. Under certain conditions, IL-4 administration slightly increased the bacterial burdens in the spleens and livers of infected mice. This finding is consistent with previous reports that endogenous IL-4, or transfer of IL-4 producing TH2 cells, can be detrimental to host defense against microbial infection.
Iizawa
Y
Y
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison.
Czuprynski
C
C
D000818:Animals; D004195:Disease Models, Animal; D015847:Interleukin-4 / Q000494:pharmacology*; D008089:Listeria monocytogenes / Q000276:immunology*; D008088:Listeriosis / Q000188:drug therapy* / Q000276:immunology; D008099:Liver / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D013154:Spleen / Q000473:pathology
D011994:Recombinant Proteins; D015847:Interleukin-4