Increased interleukin-2 level in patients with primary hypothyroidism.
The effects of hypothyroid status in humans on cytokine blood levels have been studied. Evaluations of interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), thyrotropin, thyroxine, and triiodothyronine were performed in seven patients with primary hypothyroidism and eight euthyroid healthy control subjects on the basis of venous blood samples collected after an overnight rest. A normal level of IL-1 beta (23 +/- 15 fmol/ml) and an increased IL-2 level (82 +/- 56 fmol/ml) have been shown in hypothyroid patients versus controls (IL-1 beta, 24 +/- 5 fmol/ml; IL-2, 33 +/- 13 fmol/ml). The possible role of thyroid hormones and of an autoimmune mechanism in the link with increased IL-2 blood level in hypothyroidism in man have been discussed.
Komorowski
J
J
Department of Endocrinology, Medical University of Lodz, School of Medicine, Poland.
D000328:Adult; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D007376:Interleukin-2; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine