title: Effect of cyclodextrin on the pharmacology of antifungal oral azoles.
abstract: Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.
authors.affiliation: Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
authors.forename: J S
authors.initials: JS
authors.lastname: Hostetler
authors.forename: L H
authors.initials: LH
authors.lastname: Hanson
authors.forename: D A
authors.initials: DA
authors.lastname: Stevens
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D001393:Azoles / Q000493:pharmacokinetics*; D001682:Biological Availability; D003505:Cyclodextrins / Q000494:pharmacology*; D004337:Drug Carriers; D005260:Female; D051379:Mice; D011092:Polyethylene Glycols; D047392:beta-Cyclodextrins
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D003505:Cyclodextrins; D004337:Drug Carriers; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D011092:Polyethylene Glycols