The efficacy of heparin in the treatment of common brown snake (Pseudonaja textilis) envenomation.
The efficacy of heparin therapy after subcutaneous injection of Common Brown Snake (Pseudonaja textilis) venom was studied in anaesthetised, mechanically ventilated dogs. Intravenous heparin (100 U/kg), administered fifteen minutes after envenomation, neither prevented nor hastened the recovery from cardiovascular depression and coagulopathy observed after venom administration. Heparin therapy is not recommended for the treatment of established human envenomation.
Tibballs
J
J
Animal Research Laboratory, Royal Children's Hospital, Melbourne, Victoria, Australia.
Sutherland
S K
SK
D000818:Animals; D001778:Blood Coagulation Disorders / Q000188:drug therapy* / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D004285:Dogs; D004546:Elapid Venoms / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D004562:Electrocardiography / Q000187:drug effects; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006339:Heart Rate / Q000187:drug effects; D006470:Hemorrhage / Q000209:etiology; D006493:Heparin / Q000627:therapeutic use*; D011517:Prothrombin Time; D013318:Stroke Volume / Q000187:drug effects; D013921:Thrombocytopenia / Q000188:drug therapy / Q000209:etiology; D013927:Thrombosis / Q000209:etiology; D014655:Vascular Resistance / Q000187:drug effects
D004546:Elapid Venoms; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D006493:Heparin