title: Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population.
abstract: OBJECTIVE
  To examine whether children of families moving from an area of low incidence of childhood diabetes to one which is higher show a corresponding rise in disease incidence.
  
  
  METHODS
  Disease incidence study over 12 years.
  
  
  METHODS
  Bradford District Metropolitan Council area.
  
  
  METHODS
  All subjects aged 0-16 years resident within the study area.
  
  
  METHODS
  The incidences of childhood diabetes in Asian and non-Asian families.
  
  
  RESULTS
  The incidence of diabetes in Asian children increased from 3.1/100,000 per year in 1978-81 to 11.7/100,000 per year in 1988-90 (chi 2 for trend = 4.95, df = 1, p = 0.026) whereas that for other children remained constant at 10.5/100,000 per year. Over the entire study period rates were lower in Asian females (4.9/100,000 per year) than in Asian males (8.8/100,000 per year) whereas the reverse was true for other children (males 9.2/100,000 per year; females 12.0/100,000 per year) (test for common odds ratio: chi 2 = 3.81, df = 1, p = 0.052).
  
  
  CONCLUSIONS
  Offspring of this transmigratory population had a rising incidence of childhood diabetes which was approaching that of the indigenous population. The data provide strong evidence for an environmental effect in the aetiology of insulin dependent diabetes.
authors.affiliation: Professorial Medical Unit, General Infirmary, Leeds.
authors.forename: H J
authors.initials: HJ
authors.lastname: Bodansky
authors.forename: A
authors.initials: A
authors.lastname: Staines
authors.forename: C
authors.initials: C
authors.lastname: Stephenson
authors.forename: D
authors.initials: D
authors.lastname: Haigh
authors.forename: R
authors.initials: R
authors.lastname: Cartwright
mesh_terms: D000293:Adolescent; D001208:Asia / Q000208:ethnology; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology* / Q000209:etiology*; D004739:England; D004777:Environment; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012737:Sex Factors