title: Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization.
abstract: The protein encoded by the MAX gene is a member of the class of basic region-helix-loop-helix-zipper proteins and has been demonstrated to associate with N-, L-, and c-Myc proteins both in vitro and in vivo. Heterodimers formed between c-Myc and Max proteins have been shown to possess sequence-specific DNA-binding activity. Here we report the mapping of the MAX gene to a single region on human chromosome 14 (bands q22-q24) and to mouse chromosome 12 (region D). Chromosome abnormalities linked to several neoplasms have been previously associated with this region on human chromosome 14. The mapping results also confirm a region of homology between human chromosome 14q22-24 and mouse chromosome 12 region D.
authors.affiliation: Department of Pathology, School of Medicine, University of Washington, Seattle 98195.
authors.forename: A D
authors.initials: AD
authors.lastname: Gilladoga
authors.forename: S
authors.initials: S
authors.lastname: Edelhoff
authors.forename: E M
authors.initials: EM
authors.lastname: Blackwood
authors.forename: R N
authors.initials: RN
authors.lastname: Eisenman
authors.forename: C M
authors.initials: CM
authors.lastname: Disteche
mesh_terms: D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D050976:Basic-Leucine Zipper Transcription Factors; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics; D009693:Nucleic Acid Hybridization; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D014157:Transcription Factors
chemical_list: D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C499330:MAX protein, human; C067850:Myc associated factor X; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors; C068422:Max protein, mouse