Mitotic activity of cells in the fibrous zone of the rat mandibular condyle.
To investigate cell renewal in this fibrous zone, Wistar rats at 3 and 6 weeks of age were injected intraperitoneally with colchicine (1 mg/kg) three times, at 10:00, 13:00 and 16:00 h, and mitotic cells were examined after killing the rats at 18:00 h. Colchicine induced a significant increase in the number of arrested metaphases in the fibrous and the proliferating cell zone. The mitotic rates (per 1000 cells per h) in the fibrous zone at 3 weeks of age were 0.426 for the superficial layer and 0.266 for the deeper layer. These findings suggest that the fibrous zone of young rats grew with the proliferation of the cells within this zone. Age-associated histological changes in the fibrous zone were related to changes in mitotic rates within that zone.
Mizuno
I
I
Department of Oral Surgery, Nagoya University, School of Medicine, Japan.
Saburi
N
N
Taguchi
N
N
Ueda
M
M
Kaneda
T
T
Hoshino
T
T
D000375:Aging; D000818:Animals; D002455:Cell Division / Q000502:physiology; D003094:Collagen; D005109:Extracellular Matrix / Q000648:ultrastructure; D008297:Male; D008335:Mandibular Condyle / Q000166:cytology*; D008677:Metaphase; D008938:Mitosis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003094:Collagen