Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo.
Natural abundance 13C NMR spectra obtained from 144-cm3 volumes in the human brain contained well-resolved resonances of myo-inositol after 60 min of data accumulation. A mean concentration of 7.2 +/- 0.5 mumol/g (+/- SE, n = 7) was calculated from the comparison with phantoms. 13C NMR spectroscopy thus provides a complementary role in the quantitation of metabolites also observed in the crowded 1H spectrum.
Gruetter
R
R
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut.
Rothman
D L
DL
Novotny
E J
EJ
Shulman
R G
RG
D000328:Adult; D001921:Brain / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012016:Reference Values
D007294:Inositol