title: [Treatment of primary therapy refractory choriocarcinoma using the EMA-CO protocol].
abstract: This is a report on a 33 year old patient with a metastatic gestational choriocarcinoma. The patient was hospitalized with the picture of a spontaneous left kidney rupture and nephrectomy was performed. Under primary mono-dose methotrexate chemotherapy, the patient showed rapidly progressive metastases in both lungs, liver, right kidney and soft tissue. With the use of multiple-chemotherapy, according to the EMA-CO scheme, we observed complete remission. To date, there has been no indication of any tumour recurrence.
authors.affiliation: Frauenklinik, Marienhospital Altenessen, Akademisches Lehrkrankenhaus, Universität (GHS), Essen.
authors.forename: A
authors.initials: A
authors.lastname: Fechtig
authors.forename: R P
authors.initials: RP
authors.lastname: de Dycker
authors.forename: T
authors.initials: T
authors.lastname: Schumacher
authors.forename: T
authors.initials: T
authors.lastname: Zajaczkowski
authors.forename: R L
authors.initials: RL
authors.lastname: Neumann
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007045:Hysterectomy, Vaginal; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary / Q000601:surgery; D008727:Methotrexate / Q000008:administration & dosage; D009392:Nephrectomy; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate
vernacular_title: Behandlung eines primär therapieresistenten Chorionkarzinoms nach dem EMA-CO-Schema.