title: [Acute myelogenous leukemia transformed from myelodysplastic syndrome with tetraploid chromosome constitution].
abstract: A 57-year-old female presented with general fatigue. She had neither lymphadenopathy nor hepatosplenomegaly. Laboratory data revealed anemia and leukopenia (1,500/microliters) with a differential count of 4.5% leukemic cells. The myelogram revealed 34.4% leukemic cells, of which diameter ranged from 20 to 28 microns. The diagnosis was acute myelogenous leukemia (FAB: M2) with myelodysplasia. Cytogenetic analysis revealed that the leukemic cells had chromosome abnormalities involving both diploidy and tetraploidy with structural rearrangement. Structural rearrangement included del(5) (q22q33), del(15) (q22q24), and t(3; 12) (q25;p13). Small dose aclacinomycin-A treatment was effective in reducing the number of leukemic cells in bone marrow, and both anemia and leukocytopenia were improved.
authors.affiliation: Department of Internal Medicine, Shimane Medical University.
authors.forename: H
authors.initials: H
authors.lastname: Furuya
authors.forename: S
authors.initials: S
authors.lastname: Tsuchiyama
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Ishibashi
authors.forename: K
authors.initials: K
authors.lastname: Notsu
authors.forename: C
authors.initials: C
authors.lastname: Takagi
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D011123:Polyploidy
chemical_list: D015250:Aclarubicin