title: Tumor-immunotherapy with the use of tumor-antigen-pulsed antigen-presenting cells.
abstract: Our previous study demonstrated that the administration of antigen-presenting cells (APC) pulsed with tumor cell membrane fraction to naive syngeneic mice results in effective induction of tumor-specific protective immunity in vivo. The present study examined whether tumor-antigen-pulsed APC can produce the inhibitory effect on the growth of tumor cells when administered to tumor-bearing hosts. Naive BALB/c mice were inoculated with viable tumor cells. Five days later, these mice started to receive the relevant tumor-antigen-pulsed APC at 3- to 4-day intervals. The administration of tumor-antigen-pulsed APC induced the rejection or growth inhibition of a growing tumor in approximately half of the recipient mice. Moreover, it was demonstrated that tumor-specific immunity was induced in such tumor-regressed mice. These results indicate that tumor-antigen-pulsed APC are effectively applicable to the tumor-specific immunotherapy.
authors.affiliation: Biomedical Research Center, Osaka University Medical School, Japan.
authors.forename: J P
authors.initials: JP
authors.lastname: Zou
authors.forename: J
authors.initials: J
authors.lastname: Shimizu
authors.forename: K
authors.initials: K
authors.lastname: Ikegame
authors.forename: H
authors.initials: H
authors.lastname: Takiuchi
authors.forename: H
authors.initials: H
authors.lastname: Fujiwara
authors.forename: T
authors.initials: T
authors.lastname: Hamaoka
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000637:transplantation*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D007111:Immunity, Cellular; D007167:Immunotherapy; D008212:Lymphocyte Depletion; D051379:Mice; D008807:Mice, Inbred BALB C; D012513:Sarcoma, Experimental / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm