[Effectiveness of a liposomal form of rifampicin in the treatment of experimental tuberculosis in mice].
The therapeutic effectiveness of rifampicin as a free form and a component of multilamellar phosphatidylcholine cholesterol liposomes was studied on a model of generalized tuberculosis in BALB/c mice. Rifampicin as a liposomal form was found to have no advantages over its free form. Possible mechanisms of the phenomenon and prospects for using liposomes in the chemotherapy of tuberculosis are discussed.
Kurunov
Iu N
IuN
Kaledin
V I
VI
Popova
N A
NA
Panteleeva
A G
AG
D000818:Animals; D004337:Drug Carriers; D008081:Liposomes; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012293:Rifampin / Q000008:administration & dosage*; D014376:Tuberculosis / Q000188:drug therapy*
D004337:Drug Carriers; D008081:Liposomes; D012293:Rifampin
Effektivnost' liposomal'noĭ formy rifampitsina pri lechenii éksperimental'nogo tuberkuleza mysheĭ.