Velocity storage in labyrinthine disorders.
We studied 13 patients with unilateral peripheral vestibular lesions following removal of acoustic neurinomas. The time constant of the VOR after surgery was 6.4 +/- 2.6 seconds (normal is 18.5 +/- 7.7 seconds). The time constant of OKAN after surgery was 7.2 +/- 1.8 seconds (normal is 11.3 +/- 3.2 seconds). The mean initial velocity of OKAN after surgery was 9.7 +/- 2.4 deg/second (normal is 11.7 +/- 5.9 deg/second). These data suggest that unilateral peripheral vestibular loss is associated with a complete loss of velocity storage for canal input but only a partial loss of velocity storage for visual input. These results can be accounted for by current mathematical models of the velocity storage mechanism.
Hain
T C
TC
Department of Neurology, Northwestern University School of Medicine, Chicago, Illinois 60616.
Zee
D S
DS
D006801:Humans; D007759:Labyrinth Diseases / Q000209:etiology / Q000503:physiopathology*; D008433:Mathematics; D008959:Models, Neurological; D009464:Neuroma, Acoustic / Q000601:surgery*; D012027:Reflex, Vestibulo-Ocular; D013997:Time Factors; D000159:Vestibulocochlear Nerve / Q000503:physiopathology* / Q000601:surgery