title: Second malignancies in thyroid cancer patients: a population-based survey of 3658 cases from Norway.
abstract: In a population-based survey of 3658 thyroid cancer patients diagnosed in Norway during 1955-85, a total of 200 cases of second malignancies were observed (30,414 person-years, mean follow-up 8.4 years). Male patients had a significantly increased incidence of urogenital cancer [standardised incidence ratio (SIR) = 1.96, 95% confidence interval (CI) 1.4-2.7], including cancer of the testis (SIR = 11.8, 95% CI 3.2-30.1) and urinary bladder (SIR = 3.0, 95% CI 1.5-5.2). The occurrence of malignant melanoma was also increased among males (SIR = 4.2, 95% CI 1.4-9.7). This apparent association with urogenital cancers among males at the present time cannot be explained, although increased surveillance as well as specific aetiological factors should be considered.
authors.affiliation: Department of Pathology, Gade Institute, Haukeland Hospital, Bergen, Norway.
authors.forename: L A
authors.initials: LA
authors.lastname: Akslen
authors.forename: E
authors.initials: E
authors.lastname: Glattre
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology* / Q000209:etiology; D009664:Norway / Q000453:epidemiology; D012737:Sex Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000209:etiology; D014565:Urogenital Neoplasms / Q000453:epidemiology / Q000209:etiology