The prognosis of patients with lymphomatoid papulosis associated with malignant lymphomas.
Lymphomatoid papulosis (LyP) is a disorder which generally runs a benign course, but can sometimes be associated with a malignant lymphoma. Information about the prognosis of these LyP-associated lymphomas is, however, fragmentary. In this study, the clinical data of 50 LyP-associated malignant lymphomas, including 11 patients of our own group and 39 reported in the literature, are evaluated. Three main groups of LyP-associated malignant lymphomas could be distinguished: cases associated with mycosis fungoides (19/50 cases). Hodgkin's disease (12/50 cases) and (CD30+) large-cell lymphomas (16/50). The results of this study demonstrate that patients with mycosis fungoides. Hodgkin's disease, and (CD30+) large-cell lymphomas limited to the skin have a favourable prognosis. However, the prognosis of patients developing a systemic (CD30+) large-cell lymphoma proved generally poor. The results of this study also indicate that the risk of an individual LyP patient developing systemic lymphoma is less than 5%.
Beljaards
R C
RC
Department of Dermatology, Free University Hospital, Amsterdam, The Netherlands.
Willemze
R
R
D000328:Adult; D000368:Aged; D005260:Female; D006470:Hemorrhage / Q000150:complications*; D006689:Hodgkin Disease / Q000150:complications; D006801:Humans; D008223:Lymphoma / Q000150:complications*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications; D011379:Prognosis; D012871:Skin Diseases / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications