title: Genes in the MHC that may affect antigen processing.
abstract: Recent evidence indicates that genes required for antigen processing are present in the class II region of the MHC. Two new classes of MHC genes that may encode much of the machinery required in the class I (endogenous) antigen-processing pathway have been discovered. There is evidence that genes required in the class II pathway also reside in this region.
authors.affiliation: Virginia Commonwealth University, Richmond.
authors.forename: J J
authors.initials: JJ
authors.lastname: Monaco
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000378:metabolism; D000941:Antigens / Q000378:metabolism*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D004705:Endocytosis; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism; D005796:Genes; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D051379:Mice / Q000235:genetics / Q000276:immunology; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism; D051381:Rats
chemical_list: D000941:Antigens; D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D009097:Multienzyme Complexes; D010450:Endopeptidases