On identifying a positive dose-response surface for combination agents.
This article concerns construction of a confidence surface for tangential slopes of the dose-response surface of a combination therapy to identify where response increases as a function of drug dosage. This approach extends to the assessment of the effectiveness of the combination therapy.
Hung
H M
HM
Statistical Evaluation and Research Branch, Food and Drug Administration, Rockville, MD 20857.
D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D016013:Likelihood Functions; D016015:Logistic Models; D015233:Models, Statistical