A new bradykinin-potentiating peptide (peptide P) isolated from the venom of Bothrops jararacussu (jararacuçu tapete, urutu dourado).
Several bradykinin potentiators were identified in the venom of Bothrops jararacussu by chromatographic techniques and biological assays. One of them which was isolated inhibited the angiotensin-converting enzyme in vitro and potentiated the bradykinin-induced lowering of the arterial pressure in the rat.
Ferreira
L A
LA
Serviço de Bioquímica-Lab, Cininas, Instituto Butantan, São Paulo, Brazil.
Henriques
O B
OB
Lebrun
I
I
Batista
M B
MB
Prezoto
B C
BC
Andreoni
A S
AS
Zelnik
R
R
Habermehl
G
G
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003435:Crotalid Venoms / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D007082:Ileum; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009924:Organ Culture Techniques; D051381:Rats; D012911:Snakes
D000806:Angiotensin-Converting Enzyme Inhibitors; D003435:Crotalid Venoms; D009842:Oligopeptides; C006791:bradykinin potentiating factors; D002216:Captopril; D001920:Bradykinin