title: Retrograde versus antegrade cardioplegia: impact on right ventricular function.
abstract: Retrograde cardioplegia administered through the coronary sinus has several documented advantages over antegrade cardioplegia but has been thought to provide inadequate right ventricular myocardial protection. We prospectively compared the effects of retrograde and antegrade cardioplegia on right ventricular performance in patients undergoing myocardial revascularization. Two groups of similar age, extent of disease, and preoperative left ventricular ejection fraction received retrograde (n = 16) or antegrade (n = 14) crystalloid cardioplegia. A right ventricular rapid-response thermistor catheter, previously developed and validated in our institution, was used to measure right atrial pressure, pulmonary artery pressure, right ventricular ejection fraction, end-diastolic volume index, and stroke volume index before bypass (baseline) and at several intervals after bypass. There were no differences in cross-clamp time, heart rate, cardiac enzymes, inotrope requirements, or arrhythmias between the two groups. Right ventricular parameters were equivalent in both groups at all time intervals except 30 minutes after bypass, at which time right ventricular end-diastolic volume index was lower (80 +/- 6 versus 93 +/- 6 mL/m2; p less than 0.05) and right ventricular stroke volume index was higher (35 +/- 3 versus 29 +/- 2 mL/m2, p less than 0.05) in the retrograde group compared with the antegrade group, indicating better right ventricular function with retrograde cardioplegia early after bypass. In both groups, right ventricular end-diastolic volume index was higher than baseline (p less than 0.05) during the first 4 hours after bypass. No other important differences were found.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston 29425.
authors.forename: E C
authors.initials: EC
authors.lastname: Douville
authors.forename: J M
authors.initials: JM
authors.lastname: Kratz
authors.forename: F G
authors.initials: FG
authors.lastname: Spinale
authors.forename: F A
authors.initials: FA
authors.lastname: Crawford
authors.forename: C C
authors.initials: CC
authors.lastname: Alpert
authors.forename: A
authors.initials: A
authors.lastname: Pearce
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization; D005260:Female; D006324:Heart Arrest, Induced / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000502:physiology; D013318:Stroke Volume / Q000502:physiology; D013815:Thermodilution / Q000379:methods; D016278:Ventricular Function, Right / Q000502:physiology*