title: [Mechanisms of action of medullary neurostimulation in the treatment of limb arteriopathy].
abstract: Despite 25 years of clinical practice, concerning chronic epidural spinal cord stimulation (SCS) for pain control, the mechanisms underlying the beneficial effects are still poorly understood. The main indications for SCS are intractable chronic pain secondary to neurogenic origin (essentially neuropathies by lesion of peripheral nerve or roots) or to ischemic origin. Several observations suggest that mechanisms by which SCS alleviate these two types of pain are different. In peripheral vascular disease, the analgesic effect appears as the consequence of the vasodilatory effect of SCS. The actual experimental data indicate that SCS produce its influence on peripheral microcirculation via a transitory suppression of the sympathetic vasoconstrictor control.
authors.affiliation: Service de Neurochirurgie, CHU Toulouse Rangueil.
authors.forename: Y
authors.initials: Y
authors.lastname: Lazorthes
mesh_terms: D001158:Arteries; D004599:Electric Stimulation Therapy; D005121:Extremities; D006801:Humans; D008833:Microcirculation / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D013116:Spinal Cord / Q000502:physiology*; D014652:Vascular Diseases / Q000503:physiopathology / Q000628:therapy*
vernacular_title: Mécanismes d'action de la neurostimulation médullaire dans le traitement des artériopathies des membres.