[Antagonistic properties of tetra-substituted analog of vasopressin with selective antidiuretic effects].
Biological properties of a novel vasopressin analogue were investigated. It was found that this analogue has no vasopressor and oxytocic activities but it exhibits a selective antidiuretic effect which is weaker than that of adiuretin (DDAVP). Novel analogue inhibits vasopressor, oxytocic and antidiuretic effects caused by arginine--vasopressin. The usefulness of novel compound as a pharmacological tool--vasopressin antagonist is suggested.
Myshliakova
N V
NV
Afanas'eva
G A
GA
Strazda
G M
GM
Papsuevich
O S
OS
Klusha
N V
NV
Chipens
G I
GI
D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D004232:Diuretics / Q000037:antagonists & inhibitors*; D005260:Female; D008297:Male; D051381:Rats; D013997:Time Factors
D004232:Diuretics; D001127:Arginine Vasopressin; C025043:vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-; D003894:Deamino Arginine Vasopressin
Antagonisticheskie svoĭstva chetyrekhzameshchennogo analoga vazopressina s selektivnym antidiureticheskim deĭstviem.