Evidence for a hazardous interaction between ethanol and the insecticide endosulfan in rats.
Protein supplemented diet was protective against the deleterious action of endosulfan on body growth and liver. Hepatomegaly and a reduction of body weight produced concurrently by endosulfan and ethanol were greater in male rats, suggesting that males are more susceptible than female rats to the metabolic stress caused by their interaction. Chronic endosulfan exposure resulted in a prolongation of ethanol sleeping time in female and not in male rats. This finding suggests failure of female rats to metabolize ethanol readily on account of their greater susceptibility than male rats to the hepatotoxic action of endosulfan.
Paul
V
V
Department of Pharmacology and Environmental Toxicology Dr. A. L. M. Postgraduate Institute of Basic Medical Sciences, University of Madras, India.
Balasubramaniam
E
E
Muthu
P
P
Krishnamoorthy
M S
MS
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002364:Caseins / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D004347:Drug Interactions; D004726:Endosulfan / Q000633:toxicity*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics
D002364:Caseins; D004044:Dietary Proteins; D000431:Ethanol; D004726:Endosulfan