title: [Experimental study on 123I-IMP kinetics in irradiated lung of rabbit].
abstract: Radiation-induced alteration of intra-pulmonary kinetics of 123I-IMP was investigated in 11 rabbits received a 50 Gy dose of radiation to the hemithorax. In all of these rabbits examined during 3-17 weeks following the irradiation, an abnormal accumulation was seen in the irradiated lung on the delayed image obtained 60 minutes after the injection of 123I-IMP. The time-activity curves in the irradiated lung following the injection had shallower downslopes of both the initial fast phase and the following slow phase than those of non-irradiated lung, and finally 123I-IMP uptake of the irradiated lung exceeded that of the normal lung. Chest radiographies all of 11 rabbits showed no abnormal shadow and histological studies in 6 of them revealed a relatively slight change or injury of the irradiated lung during 3-17 weeks. These results indicate that this agent may be useful for detecting and assessing relatively early and slight lung injury induced by irradiation.
authors.affiliation: Department of Radiology, Yamaguchi University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Suga
authors.forename: I
authors.initials: I
authors.lastname: Ariyoshi
authors.forename: K
authors.initials: K
authors.lastname: Nishigauchi
authors.forename: T
authors.initials: T
authors.lastname: Nakanishi
authors.forename: H
authors.initials: H
authors.lastname: Utsumi
authors.forename: N
authors.initials: N
authors.lastname: Yamada
mesh_terms: D000662:Amphetamines / Q000493:pharmacokinetics; D000818:Animals; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D020367:Iofetamine; D008168:Lung / Q000000981:diagnostic imaging* / Q000528:radiation effects; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
chemical_list: D000662:Amphetamines; D007457:Iodine Radioisotopes; D020367:Iofetamine