title: Cerebral blood flow and intracranial pressure during experimental subarachnoid haemorrhage.
abstract: The relationships of intracranial pressure (ICP), systemic blood pressure (SBP) and cerebral blood flow (CBF) during experimental subarachnoid haemorrhage were investigated in cats. Continuous monitoring of regional cerebral blood flow (rCBF) was done by a thermal diffusion method using a Peltier stack. During haemorrhage ICP rose within 5.4 +/- 0.97 minutes from 10.5 +/- 4.9 to 176.1 +/- 27.8 mmHg. This strong increase of ICP resulted in a temporary arrest of cerebral circulation. The Cushing response during the haemorrhage could not improve the cerebral circulation, but in contrast caused a further increase of ICP. After the haemorrhage the cerebral blood flow normalised within minutes. It is concluded, that the Cushing response during a subarachnoid haemorrhage should be regarded as a deleterious rather than a beneficial mechanism.
authors.affiliation: Neurosurgical Department, Medical School Hannover, Federal Republic of Germany.
authors.forename: T
authors.initials: T
authors.lastname: Brinker
authors.forename: V
authors.initials: V
authors.lastname: Seifert
authors.forename: H
authors.initials: H
authors.lastname: Dietz
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D001929:Brain Edema / Q000503:physiopathology; D002415:Cats; D005260:Female; D006706:Homeostasis / Q000502:physiology; D007427:Intracranial Pressure / Q000502:physiology*; D008297:Male; D012039:Regional Blood Flow / Q000502:physiology; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*