Acute monocytic leukemia with (8;22)(p11;q13) translocation. Involvement of 8p11 as in classical t(8;16)(p11;p13).
A new case of acute monocytic leukemia observed in a 73-year-old male (ANLLM5) with an unusual t(8;22)(p11;q13) is reported. The blasts did not demonstrate erythrophagocytosis, but the presence of both naphthol-ASD-chloro-acetate esterase and butyrate esterase activities was similar to that seen in cases with t(8;16)(p11;p13). Involvement of the 8p11 region in ANLLM4 and M5 is discussed, being the third most frequent rearrangement in acute leukemia with monocytic components seen at our Center.
Lai
J L
JL
Service de Cytogénétique, Faculté de Médecine Lille, France.
Zandecki
M
M
Fenaux
P
P
Preudhomme
C
C
Facon
T
T
Deminatti
M
M
D000368:Aged; D002265:Carboxylic Ester Hydrolases / Q000032:analysis; D002880:Chromosomes, Human, Pair 11; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009283:Naphthol AS D Esterase / Q000032:analysis; D014178:Translocation, Genetic / Q000235:genetics*
D009283:Naphthol AS D Esterase; D002265:Carboxylic Ester Hydrolases; C021487:butyrylesterase