Establishment of the ethanol-induced place preference in rats.
Ethanol failed to induce a place preference in both 15 and 50 min conditioning schedules in free-feeding and in food deprived rats. Acetaldehyde, the primary metabolic product of ethanol, induced a weak place aversion, dose-dependently. Ethanol combined with pyrazole (an alcohol dehydrogenase inhibitor) significantly induced a place preference in rats (ethanol; 300 mg/kg, i.p., pyrazole; 100 mg/kg, i.p.) in a 50 min conditioning schedule. The ethanol (300 mg/kg) combined with pyrazole (100 mg/kg)-induced place preference was antagonized or reduced by 5-HT3 antagonists (MDL72222, ICS205-930). These results suggest that a blockade of ethanol metabolism is very important for development of the ethanol-induced place preference in rats, and that the ethanol-induced place preference may be mediated by the mesolimbic dopamine system through 5-HT3 receptors.
Suzuki
T
T
Department of Applied Pharmacology, School of Pharmacy, Hoshi University.
Shiozaki
Y
Y
Moriizumi
T
T
Misawa
M
M
D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology; D008297:Male; D011720:Pyrazoles / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology; D014326:Tropanes / Q000494:pharmacology; D000077526:Tropisetron
D007211:Indoles; D011720:Pyrazoles; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014326:Tropanes; D000431:Ethanol; C031280:pyrazole; D000077526:Tropisetron; C042253:bemesetron