Effects of selective CCK receptor agonists on food intake after central or peripheral administration in rats.
In this paper report the effects of peripheral (intraperitoneal, i.p.) and central (intracerebroventricular, i.c.v.) injection of selective cholecystokinin (CCK) receptor agonists on food intake in the rat. Stimulation of peripheral and central CCK-A receptors by the selective CCK-A receptor agonist A-71623 suppressed intakes of a liquid diet in both deprived and sated rats. In contrast, i.c.v., but not i.p., injections of the selective CCK-B receptor agonist A-63387, reduced food intakes, although on a molar basis the effect was much less than that seen with A-71623. Although these results stress the relative importance of the CCK-A receptor in the effects of exogenous CCK-8 administration on feeding, stimulation of the CCK-B receptor may still be involved in the control of feeding following the endogenous release of CCK.
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Neuroscience Research Division, Abbott Laboratories Abbott Park, IL 60064.
Gore
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Bednarz
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Holladay
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Nadzan
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D000704:Analysis of Variance; D000818:Animals; D000855:Anorexia / Q000139:chemically induced; D001921:Brain / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011949:Receptors, Cholecystokinin / Q000145:classification / Q000502:physiology*; D013758:Tetragastrin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D009842:Oligopeptides; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; C066278:A 71623; C075264:A 63387