Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerates healing.
Prostaglandins have been demonstrated to have a mucosal protective effect when administered prior to the experimental induction of colitis in animals. We here determined whether prostaglandins would have a beneficial therapeutic effect when administered after colitis had been established. Diffuse, chronic, trinitrobenzene sulfonic acid-induced colitis was established in rats, and misoprostol was administered daily for up to 10 days following the induction of colitis. The effects of misoprostol therapy were compared to those obtained by treatment with 5-aminosalicylic acid and betamethasone. Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerated colonic healing, as measured in terms of macroscopic ulceration area and fluid absorption, whereas 5-aminosalicylic acid and betamethasone therapy did not. Ileal fluid absorption impairment was repaired by betamethasone but not by misoprostol or 5-aminosalicylic acid therapy.
Torsher
K J
KJ
University of Alberta, Division of Gastroenterology, Edmonton, Canada.
Empey
L R
LR
Fedorak
R N
RN
D000636:Aminosalicylic Acids / Q000627:therapeutic use; D000818:Animals; D001623:Betamethasone / Q000627:therapeutic use; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D008297:Male; D019804:Mesalamine; D016595:Misoprostol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014302:Trinitrobenzenesulfonic Acid
D000636:Aminosalicylic Acids; D016595:Misoprostol; D019804:Mesalamine; D014302:Trinitrobenzenesulfonic Acid; D001623:Betamethasone