title: A human moderately repeated Y-specific DNA sequence is evolutionarily conserved in the Y chromosome of the great apes.
abstract: Evolutionary conservation of the human-derived moderately repeated Y-specific DNA sequence Y-190 (DYZ5) was investigated in the chimpanzee, orangutan, and gorilla. Southern blot analysis showed the presence of the sequence in the Y chromosome of all great apes. Pulsed-field gel electrophoresis and in situ hybridization revealed that the repeat is organized in one major block and confined to a small region of the Y chromosome of the three species. DYZ5 was assigned to the proximal short arm of the Y chromosome of the chimpanzee and orangutan and to the long arm of the Y chromosome of the gorilla. In light of its evolutionary conservation, DYZ5 may have an as yet undetermined structural function in the Y chromosome.
authors.affiliation: Department of Human Genetics, University of Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Guttenbach
authors.forename: U
authors.initials: U
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Schmid
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D005260:Female; D005819:Genetic Markers; D006071:Gorilla gorilla / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes / Q000235:genetics*; D010802:Phylogeny; D011148:Pongo pygmaeus / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014998:Y Chromosome
chemical_list: D005819:Genetic Markers