Multiple-dose sodium polystyrene sulfonate in lithium intoxication: an animal model.
Previous work in our laboratory has demonstrated that sodium polystyrene sulfonate (SPS) significantly lowered serum lithium (Li) concentrations when administered in a single oral dose after an oral dose of lithium in a mouse model. The present study was designed to determine whether: 1) repetitive doses of SPS are effective in lowering serum lithium concentrations, 2) the effect of SPS on lithium concentration is dose related and 3) SPS enhances the elimination of lithium. Mice (N = 144) were given orogastric LiCl (250 mg/kg) and then divided into 4 groups: Controls received water 0, 30, 90, 180, and 360 min. after LiCl; the Full-Dose SPS Group received SPS (5 g/kg/dose) at equivalent times; the Half-Dose SPS Group received SPS (2.5 g/kg/dose) at the same times; and the Elimination Group received water at 0 and 30 min. after LiCl and SPS at 90, 180 and 360 min. after LiCl. Subgroups of each group were sacrificed at 1, 2, 4 and 8 hr post-treatment and serum analyzed for lithium concentrations. Statistical analyses revealed that, when compared to Controls: 1) SPS significantly lowered serum lithium concentrations; 2) this effect was dose-related; 3) repetitive dosing of SPS appears to enhance the elimination of lithium.
Linakis
J G
JG
Program in Clinical Pharmacology/Toxicology, Children's Hospital, Harvard University, Boston, MA.
Eisenberg
M S
MS
Lacouture
P G
PG
Maher
T J
TJ
Lewander
W J
WJ
Driscoll
J L
JL
Woolf
A
A
D000818:Animals; D002411:Cation Exchange Resins / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D008094:Lithium / Q000097:blood / Q000506:poisoning*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011137:Polystyrenes / Q000008:administration & dosage / Q000494:pharmacology*; D012117:Resins, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*
D002411:Cation Exchange Resins; D011137:Polystyrenes; D012117:Resins, Synthetic; C003321:polystyrene sulfonic acid; D008094:Lithium