Effect of cycloheximide on the adaptive response induced by low dose radiation.
Human lymphocytes pre-exposed to 10 mGy or 50 mGy of X-rays become less sensitive to subsequent large dose irradiation, exhibited lower rate of chromosome aberration than expected. This adaptive response could be inhibited by cycloheximide, a protein synthesis inhibitor for successive 2 h period ranging from 0.5h before to 4h after the low dose exposure, indicating that the adaptive response was directly related with the protein synthesis.
Cai
L
L
Department of Radiation Biology, Norman Bethune University of Medical Sciences, Changchun, China.
Liu
S
S
D000222:Adaptation, Physiological; D002869:Chromosome Aberrations; D003513:Cycloheximide / Q000633:toxicity*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000502:physiology / Q000528:radiation effects*; D008297:Male
D003513:Cycloheximide