title: Coagulopathy and intraoperative blood salvage (IBS).
abstract: The use of potentially contaminated shed blood and the contribution of autotransfused blood to coagulopathy are controversial issues associated with intraoperative blood salvage (IBS) in trauma patients. Intraoperative blood salvage was used in 154 trauma patients and resulted in reinfusion of 7.97 units per patient. Moderate to severe abnormalities of the prothrombin time (PT) and partial thromboplastin time (PTT) occurred in 39 patients (31%). Prolongation of the PT and PTT occurred with increasing transfusion. Coagulopathy was seen in patients receiving greater than 15 IBS units and in patients receiving greater than 50 combined units of blood. Of the 66 patients with bowel injury, 58 patients received shed blood. Patients with bowel injury showed no increase in infection but did develop prolongation of PT and PTT at lower levels of IBS transfusion. Based on the results of this study, patients receiving greater than 15 units of IBS transfusion require careful monitoring and factor replacement, and IBS transfusion should be limited to less than 10 units in patients with bowel injury.
authors.affiliation: Department of Surgery, Henry Ford Hospital, Detroit, MI 48202.
authors.forename: H M
authors.initials: HM
authors.lastname: Horst
authors.forename: S
authors.initials: S
authors.lastname: Dlugos
authors.forename: J J
authors.initials: JJ
authors.lastname: Fath
authors.forename: V J
authors.initials: VJ
authors.lastname: Sorensen
authors.forename: F N
authors.initials: FN
authors.lastname: Obeid
authors.forename: B A
authors.initials: BA
authors.lastname: Bivins
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous / Q000009:adverse effects / Q000379:methods*; D002648:Child; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D014947:Wounds and Injuries / Q000601:surgery*