[2 infectious granulomatous diseases (leprosy and cutaneous and mucous leishmaniasis) by scintigraphic methods].
Leprosy is a multiform chronic infectious granulomatous disease caused by Mycobacterium leprae, that affects over 12 million people in the world. Cutaneous and mucous leishmaniasis (CML) is also a chronic granulomatous infectious disease, caused by Leishmania brasiliensis and transmitted to man by the mosquitoes of the Phlebotominae family. It is a worldwide spread disease. We studied one case of Borderline-wirchowian leprosy and 2 cases of CML with Gallium-67 (GA-67) scintigraphy. Ga-67 is a radiopharmaceutical known for its property of concentrating in inflammatory sites. In the leprosy patient, Ga-67 accumulated in the skin in a moderate, homogeneous and disseminated way (outlined skin); in the area of the face, the uptake was important and homogeneous (image in beard). Several internal organs accumulated Ga-67. As for the 2 CML patients, Ga-67 accumulated focally, in different degrees, in the affected anatomical areas. The leprosy patient was not under treatment and the 2 CML were under treatment (20 and 40 days, respectively). In the 3 cases, all affected areas accumulated Ga-67. Intensity differences of uptake may be explained both by different degrees of inflammatory processes (between leprosy and CML) and by treatment lasting. It is possible that Ga-67 scintigraphy may be useful for the evaluation of these 2 diseases extent and also for the therapy follow-up.
Braga
F J
FJ
Département de Radiologie, Hospital das Clínicas, Faculté de Médecine, Université de São Paulo, Brésil.
Abreu
C M
CM
Abreu
P R
PR
Camargo
E E
EE
Rivitti
M C
MC
Tedesco-Marchesi
L C
LC
Gambini
D J
DJ
Barritault
L
L
D000328:Adult; D000368:Aged; D005710:Gallium Radioisotopes; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000000981:diagnostic imaging*; D007897:Leishmaniasis, Mucocutaneous / Q000000981:diagnostic imaging*; D007918:Leprosy / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging
D005710:Gallium Radioisotopes
Contribution au début de l'étude de deux maladies infectieuses granulomateuses (la lèpre et la leishmaniose cutanée et muqueuse) par des méthodes scintigraphiques.