title: Interaction of large granular lymphocytes with susceptible target does not induce second messenger and cytolytic granule exocytosis.
abstract: We studied the activation signals of LGL, from LDGL patients, following incubation with susceptible K562 target cells. The findings showed that LGL lysis is independent of [Ca2+]i rise and cytolytic granule exocytosis, and most likely involves alternative, as yet unidentified, mechanisms.
authors.affiliation: Institute of Oncology, Inter-University Center for Cancer Research, University of Padova, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pollis
authors.forename: A
authors.initials: A
authors.lastname: Rosato
authors.forename: V
authors.initials: V
authors.lastname: Bronte
authors.forename: S
authors.initials: S
authors.lastname: Mandruzzato
authors.forename: A
authors.initials: A
authors.lastname: Zambon
authors.forename: R
authors.initials: R
authors.lastname: Zambello
authors.forename: P
authors.initials: P
authors.lastname: Pizzo
authors.forename: P
authors.initials: P
authors.lastname: Zanovello
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D053804:Granzymes; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000145:classification / Q000378:metabolism*; D015290:Second Messenger Systems; D012697:Serine Endopeptidases / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology*
chemical_list: D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human; D002118:Calcium