The structure of mytilan, a bioglycan-immunomodulator isolated from the mussel Crenomytilus grayanus.
Mytilan, isolated from the mantle of the mussel Crenomytilus grayanus and which possesses high immunomodulating activity, is a non-covalently linked complex of a polysaccharide (95%) and protein (5%) with lectin activities. Chromatography of mytilan on agarose separated the polysaccharide and protein constituents. The protein appeared to have the lectin properties. Methylation analysis, Smith degradation, digestion with alpha-amylase, and 13C-n.m.r. spectroscopy showed the polysaccharide to be a glycogen-like alpha-D-glucan.
Ovodova
R G
RG
Pacific Institute of Bioorganic Chemistry, U.S.S.R. Academy of Sciences, Vladivostok.
Glazkova
V E
VE
Mikheyskaya
L V
LV
Molchanova
V I
VI
Isakov
V V
VV
Ovodov
Y S
YS
Fernandez Molina
L E
LE
D000276:Adjuvants, Immunologic; D000818:Animals; D049872:Bivalvia / Q000737:chemistry*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002846:Chromatography, Affinity; D002850:Chromatography, Gel; D008745:Methylation; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009904:Optical Rotation; D011134:Polysaccharides / Q000737:chemistry* / Q000302:isolation & purification; D000516:alpha-Amylases
D000276:Adjuvants, Immunologic; D011134:Polysaccharides; C030207:mytilan; D000516:alpha-Amylases