Inhibitory effects of polyethers on human immunodeficiency virus replication.
We examined the inhibitory activities of 10 polyether antibiotics on human immunodeficiency virus (HIV) type 1. These compounds caused concentration-dependent inhibition of HIV replication in primary infected cultures of human T-lymphoblastoid H9 cells. The ratio of 50% effective concentrations for cellular cytotoxicity (MTT assay) to antiviral activity (reverse transcriptase assay) was over 5. Anti-HIV activity was also observed in cultures of monocytic lineage U937 cells chronically infected with HIV.
Nakamura
M
M
Department of Microbiology, Jikei University School of Medicine, Tokyo, Japan.
Kunimoto
S
S
Takahashi
Y
Y
Naganawa
H
H
Sakaue
M
M
Inoue
S
S
Ohno
T
T
Takeuchi
T
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004987:Ethers / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects* / Q000472:pathogenicity; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D004987:Ethers