title: Mid-dermal elastolysis with inflammation.
abstract: A 71-year-old white woman had finely wrinkled, erythematous patches of skin that met the clinical and histologic criteria for mid-dermal elastolysis. In addition to the loss of mid-dermal elastin described in previous cases, histopathologic examination revealed a superficial and deep perivascular inflammatory infiltrate of lymphocytes and plasma cells and interstitial collections of multinucleated giant cells containing phagocytized elastin. These results support a previously postulated inflammatory pathogenesis for mid-dermal elastolysis.
authors.affiliation: Department of Dermatology, University of Pittsburgh School of Medicine, Pa.
authors.forename: B A
authors.initials: BA
authors.lastname: Brod
authors.forename: M
authors.initials: M
authors.lastname: Rabkin
authors.forename: A R
authors.initials: AR
authors.lastname: Rhodes
authors.forename: B V
authors.initials: BV
authors.lastname: Jegasothy
mesh_terms: D000368:Aged; D001284:Atrophy / Q000209:etiology; D003483:Cutis Laxa / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003872:Dermatitis / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology*; D004890:Erythema / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005542:Forearm; D006801:Humans; D007868:Leg Dermatoses / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology; D013848:Thigh