title: Nasal inhalation challenge studies with sidestream tobacco smoke.
abstract: Environmental tobacco smoke (ETS) exposure is associated with rhinitis symptoms (i.e., runny nose and congestion) in some people. In an effort to better understand these symptoms, we recruited 18 historically ETS-sensitive subjects from the community and exposed them for 15 min to clean air and for 15 min to sidestream tobacco smoke (STS, 45 ppm carbon monoxide). Symptoms were recorded (0 = absent, 5 = severe), and posterior rhinomanometry was performed. There were significant changes in rhinitis symptoms (1.3 +/- 0.4 pre- versus 6.1 +/- 0.5 post-STS, p less than .05); nasal airway resistance (2.86 +/- 0.2 pre- versus 4.49 +/- 0.6 post-STS, p less than .05), and maximum inspiratory flow (2.74 +/- 0.3 pre- versus 2.14 +/- 0.3 post-STS, p less than .05). A spectrum of individual responsiveness to ETS was observed, and nasal resistance increased from 0% to 265%. Increased nasal resistance occurred primarily at the upstream or flow-limiting segment of the nasal airway.
authors.affiliation: Environmental Research Facility, University of Maryland School of Medicine, Baltimore.
authors.forename: S R
authors.initials: SR
authors.lastname: Willes
authors.forename: T K
authors.initials: TK
authors.lastname: Fitzgerald
authors.forename: R
authors.initials: R
authors.lastname: Bascom
mesh_terms: D000328:Adult; D000403:Airway Resistance; D004305:Dose-Response Relationship, Drug; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007320:Inspiratory Capacity; D008297:Male; D008365:Manometry; D009299:Nasal Provocation Tests; D010947:Plants, Toxic; D012220:Rhinitis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012720:Severity of Illness Index; D014026:Nicotiana / Q000145:classification; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000032:analysis
chemical_list: D014028:Tobacco Smoke Pollution