title: Activin synergistically increased c-jun mRNA in P19 embryonal carcinoma cells in the presence of retinoic acid.
abstract: Activin and retinoids, which are involved in the induction and regulation of the early differentiation process in vertebrate embryogenesis, synergistically increased the amount of c-jun mRNA in P19 embryonal carcinoma cells, but activin alone had no effect. Among the retinoids, all-trans-retinoic acid most effectively increased c-jun mRNA. Activin (lng/ml) was sufficient to induce the synergistic increase of c-jun mRNA in P19 EC cells with all-trans-retinoic acid. The synergistic increase of the amount of c-jun mRNA by their cooperative action may be important in vertebrate development.
authors.affiliation: National Institute of Neuroscience, NCNP, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Momoi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Momoi
authors.forename: Y
authors.initials: Y
authors.lastname: Etoh
mesh_terms: D028341:Activins; D000818:Animals; D002460:Cell Line; D004357:Drug Synergism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D016758:Genes, jun / Q000187:drug effects*; D006133:Growth Substances / Q000494:pharmacology*; D007265:Inhibins / Q000494:pharmacology*; D007700:Kinetics; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D013724:Teratoma; D014158:Transcription, Genetic / Q000187:drug effects*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D006133:Growth Substances; D012333:RNA, Messenger; D028341:Activins; D014212:Tretinoin; D007265:Inhibins