Intratumoral gamma-linoleic acid therapy of human gliomas.
In vitro and in vivo studies have shown that gamma-linoleic acid (GLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can selectively kill tumor cells. In a clinical trial, the effectiveness of intratumoral administration of GLA in patients with gliomas was studied. Of the 6 patients treated, all showed substantial response to GLA as documented by computerized tomography. There were no acute side-effects due to the therapy. This report demonstrates that intratumoral administration of GLA is a possible approach to the treatment of human glial tumors.
Naidu
M R
MR
Department of Neurosurgery, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India.
Das
U N
UN
Kishan
A
A
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D007276:Injections, Intraventricular; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents; D008041:Linoleic Acids; D019787:Linoleic Acid