Protecting effects of vasoactive intestinal polypeptide on lymphocytes against metal toxicity.
The hormonal neuropeptides calcitonin gene-related peptide (CGRP), cholecystokinin (CCK), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP), were investigated for a potential protective effect on thymocytes after a toxic dose of nickel sulfate, giving an inhibition of DNA synthesis. There was a statistically significant increase in the synthesis of DNA from the level caused by nickel sulfate, with VIP, 10(-4)-10(-5) mol/l, while the slightly stimulating effects obtained with CGRP, CCK and NPY, were statistically non-significant. This indicates that VIP, at least as pharmacological concentrations, might have protective effects on lymphocytes against metal toxicity.
Nordlind
K
K
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Bondesson
L
L
Agerberth
B
B
Mutt
V
V
D002478:Cells, Cultured; D002648:Child; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D009479:Neuropeptides / Q000494:pharmacology; D009532:Nickel / Q000633:toxicity*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D009479:Neuropeptides; D014660:Vasoactive Intestinal Peptide; D009532:Nickel; D004247:DNA