title: Complications of intrathecal baclofen delivery.
abstract: The medical records of 46 consecutive patients who have had intrathecal Baclofen drug delivery systems implanted in the National Spinal Injuries Centre, the Paddocks Hospital Spinal Unit, Princes Risborough, Lodge Moor Hospital Spinal Unit, Sheffield, the Northern Regional Spinal Injuries Unit, Hexham and The Radcliffe Infirmary, Oxford, were reviewed. Patients were contacted to describe their views on the treatment. The complications of the treatment are described. Some, such as overdose and meningitis are particularly hazardous. Others, in particular pump tubing revisions, are more of an inconvenience and time consuming for the patient and physician. If the serious risks of this valuable treatment are to be minimized and the therapy applied most effectively than a well co-ordinated team is essential, involving in particular the physician responsible for the initial assessment and follow-up of the patient and an experienced surgeon. It is recommended that only a small number of centres in the UK undertake these implants.
authors.affiliation: National Spinal Injuries Centre, Stoke Mandeville Hospital, Aylesbury, Bucks, UK.
authors.forename: P
authors.initials: P
authors.lastname: Teddy
authors.forename: A
authors.initials: A
authors.lastname: Jamous
authors.forename: B
authors.initials: B
authors.lastname: Gardner
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Silver
mesh_terms: D000293:Adolescent; D000328:Adult; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects* / Q000506:poisoning; D062787:Drug Overdose / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D013118:Spinal Cord Diseases / Q000150:complications / Q000188:drug therapy*; D013119:Spinal Cord Injuries / Q000150:complications / Q000188:drug therapy*
chemical_list: D001418:Baclofen