title: The influence of the In(Lu) gene on expression of CDw75 antigens on human red blood cells.
abstract: The influence of the In(Lu) gene on human red blood cell (RBC) expression of CDw75 antigens was examined. CDw75 antigens were increased in expression on Lu(a-b-) cells of the dominant inhibitor type in comparison with red cells from donors of other Lutheran (Lu) phenotypes. In contrast, CD44 epitopes detected with F10-44-2, A3D8 and BU52 monoclonal antibodies (mAb) were decreased in expression on Lu(a-b-) red cells. Among normal blood donors of the common phenotype Lu(a-b+) there was a wide range of expression of CDw75 antigens on red cells. The results show that CDw75 is a quantitative polymorphism of human red cells and, among antigens influenced by the In(Lu) gene, is unique in being up-regulated in expression.
authors.affiliation: Human Genetics Unit, Western General Hospital, Edinburgh, U.K.
authors.forename: K
authors.initials: K
authors.lastname: Guy
authors.forename: C
authors.initials: C
authors.lastname: Green
mesh_terms: D015703:Antigens, CD / Q000032:analysis / Q000235:genetics*; D004912:Erythrocytes / Q000276:immunology*; D005799:Genes, Dominant / Q000276:immunology*; D006801:Humans; D008188:Lutheran Blood-Group System / Q000235:genetics*; D016201:Receptors, Lymphocyte Homing / Q000032:analysis; D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase
chemical_list: D015703:Antigens, CD; D008188:Lutheran Blood-Group System; D016201:Receptors, Lymphocyte Homing; D012799:Sialyltransferases; C093493:ST6GAL1 protein, human; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase