title: [The binding of 5-fluorouracil to serum protein fractions, erythrocytes and ghosts under in vitro conditions].
abstract: The binding of 5-fluorouracil (1) to erythrocytes and to serum proteins under in vitro conditions was investigated. The binding rate of 1 to erythrocytes is dose-independent and amounts from 16.8 to 31.7% (concentration range 1 to 20 micrograms/ml). The mean coefficient of partition for erythrocytes is 0.25 (+/- 0.03), no binding to ghosts was observed. 1 is bound at about 4% to proteins, whereby 0.7% are bound to alpha-globulin, 0.8% to beta-globulin, 1.6% to gamma-globulin, and 0.8% to albumine. The mean partition coefficient for proteins is 0.04 (+/- 0.006).
authors.affiliation: Institut für Pharmazeutische Chemie, Universität Wien, Osterreich.
authors.forename: M
authors.initials: M
authors.lastname: Czejka
authors.forename: J
authors.initials: J
authors.lastname: Schüller
mesh_terms: D001798:Blood Proteins / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005472:Fluorouracil / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D005472:Fluorouracil
vernacular_title: Bindung von 5-Fluorouracil an Serumproteinfraktionen, Erythrozyten und Ghosts unter in vitro Bedingungen.