title: In-vitro activity of cefpirome against isolates from patients with urinary tract, lower respiratory tract and wound infections.
abstract: The in-vitro activity of cefpirome, a new injectable cephalosporin, was compared with that of several other antibiotics against bacterial isolates from hospitalized patients with lower respiratory tract infections, urinary tract infections and wound infections. Minimum inhibitory concentrations were determined for 874 strains against 16 antibiotics using a microtitration technique. Cefpirome showed a very broad spectrum of activity against most pathogens tested. The spectrum included organisms such as Staphylococcus spp., enterococci, Enterobacter spp., and Pseudomonas spp. which are frequently resistant to third generation cephalosporins.
authors.affiliation: Johann Wolfgang Goethe University Hospital, Frankfurt, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Schäfer
authors.forename: P M
authors.initials: PM
authors.lastname: Shah
authors.forename: H W
authors.initials: HW
authors.lastname: Doerr
authors.forename: M
authors.initials: M
authors.lastname: Ziemen
authors.forename: S
authors.initials: S
authors.lastname: Hellwich
authors.forename: G
authors.initials: G
authors.lastname: Seibert
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D012141:Respiratory Tract Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects; D014552:Urinary Tract Infections / Q000382:microbiology*; D014946:Wound Infection / Q000382:microbiology*; D000097572:Cefpirome
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000097572:Cefpirome