title: Psychoactive substance use disorder in relatives of patients with anorexia nervosa.
abstract: We assessed the lifetime prevalence and morbid risk of psychoactive substance use disorder (SUD; alcoholism and drug use disorder) in the first- and second-degree relatives, excluding children, of 34 female patients with anorexia nervosa (AN) and 34 age- and sex-matched controls who had no history of an eating disorder. Diagnoses of relatives were made blind to probands' diagnoses. The prevalence of SUD was 9% in both anorectic and control relatives, and the figures for morbid risk were 14% and 15%, respectively; these differences were nonsignificant. These results suggest that adolescent and adult women with AN do not possess many of the familial factors that predispose to the development of psychoactive SUD.
authors.affiliation: Department of Psychiatry, Ohio State University, Columbus 43210-1228.
authors.forename: S L
authors.initials: SL
authors.lastname: Stern
authors.forename: K N
authors.initials: KN
authors.lastname: Dixon
authors.forename: R A
authors.initials: RA
authors.lastname: Sansone
authors.forename: M D
authors.initials: MD
authors.lastname: Lake
authors.forename: E
authors.initials: E
authors.lastname: Nemzer
authors.forename: D
authors.initials: D
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D000856:Anorexia Nervosa / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002032:Bulimia / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D005260:Female; D006801:Humans; D011619:Psychotropic Drugs; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology
chemical_list: D011619:Psychotropic Drugs