title: Fatal hyperthermia in a quadriplegic man. Possible evidence for a peripheral action of haloperidol in neuroleptic malignant syndrome.
abstract: A patient with a cervical cord transection isolating his hypothalamic thermoregulatory centers from peripheral effectors suffered a fatal hyperthermic episode after receiving haloperidol. This suggests that neuroleptic malignant syndrome is caused by a peripheral, not central, effect of haloperidol.
authors.affiliation: Columbia-Presbyterian Medical Center, New York.
authors.forename: R J
authors.initials: RJ
authors.lastname: Downey
authors.forename: J A
authors.initials: JA
authors.lastname: Downey
authors.forename: E
authors.initials: E
authors.lastname: Newhouse
authors.forename: C
authors.initials: C
authors.lastname: Weissman
mesh_terms: D000328:Adult; D005334:Fever / Q000139:chemically induced* / Q000473:pathology; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology* / Q000473:pathology; D011782:Quadriplegia / Q000150:complications* / Q000209:etiology / Q000473:pathology; D013119:Spinal Cord Injuries / Q000150:complications / Q000473:pathology; D014948:Wounds, Gunshot / Q000150:complications / Q000473:pathology
chemical_list: D006220:Haloperidol