title: Carbon catabolite regulation of gentamicin formation.
abstract: The effect of utilizable carbon sources on the production of gentamicin by Micromonospora purpurea has been studied. High D-glucose and D-xylose concentrations (40 mg/ml), exerted a strong and permanent negative action on antibiotic formation. On the other hand, similar concentrations of D-fructose, D-mannose, maltose and starch caused no effect. The glucose action is seen only if added during the logarithmic growth phase; moreover, the sugar needs to be metabolized to show its negative effect.
authors.affiliation: Departamento de Biotecnologia, Universidad Nacional Autonoma de Mexico, Mexico D.F.
authors.forename: L
authors.initials: L
authors.lastname: Escalante
authors.forename: R
authors.initials: R
authors.lastname: Gonzalez
authors.forename: A M
authors.initials: AM
authors.lastname: Obregon
authors.forename: S
authors.initials: S
authors.lastname: Sanchez
mesh_terms: D050260:Carbohydrate Metabolism; D003470:Culture Media; D005839:Gentamicins / Q000096:biosynthesis*; D005947:Glucose / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008828:Microbiological Techniques; D008847:Micromonospora / Q000378:metabolism*; D014994:Xylose / Q000378:metabolism*
chemical_list: D003470:Culture Media; D005839:Gentamicins; D014994:Xylose; D005947:Glucose