title: The methyltrienolone binding protein of JEG-3 cells and human placenta is localized within the nucleus and is tightly associated with chromatin.
abstract: Human placenta contains the methyltrienolone binding protein (MTBP), an androgen binding protein which is distinct from the androgen receptor. This study demonstrates that the human choriocarcinoma cell line (JEG-3) also contains the MTBP and that in both human placenta and JEG-3 cells the MTBP is located exclusively in the nucleus and in particular is associated with DNase 1 resistant chromatin.
authors.affiliation: Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, Australia.
authors.forename: J O
authors.initials: JO
authors.lastname: Macaulay
authors.forename: G L
authors.initials: GL
authors.lastname: Warne
authors.forename: Z S
authors.initials: ZS
authors.lastname: Krozowski
mesh_terms: D000727:Androgen-Binding Protein / Q000378:metabolism*; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism; D002822:Choriocarcinoma; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D015741:Metribolone / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010920:Placenta / Q000378:metabolism* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
chemical_list: D000727:Androgen-Binding Protein; D002843:Chromatin; D009687:Nuclear Proteins; C028867:methyltrienolone binding protein, human; D015741:Metribolone