Chronic granulomatous disease: diagnosis and classification at the molecular level.
Chronic granulomatous disease (CGD) is caused by the failure of phagocytes to produce microbicidal derivatives of molecular oxygen, such as hydrogen peroxide. It is one of the best characterized of the phagocyte disorders and represents an important consideration in the differential diagnosis of recurrent infections. The clinical, biochemical, and molecular genetic aspects of CGD are reviewed in this context in this article.
Hopkins
P J
PJ
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla.
Bemiller
L S
LS
Curnutte
J T
JT
D000595:Amino Acid Sequence; D001483:Base Sequence; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000145:classification / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009247:NADH, NADPH Oxidoreductases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019255:NADPH Oxidases; D010586:Phagocytes / Q000502:physiology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016897:Respiratory Burst / Q000502:physiology
D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases