title: [Regulatory properties of the rat heart adenylate cyclase in the course of toxic-infective shock caused by Yersinia pestis].
abstract: Influence of intravenously administered to rats murine toxin of Y. pestis in the dose of I mg/ml (LD100) on the regulatory properties of heart plasma membranes adenylate cyclase (AC) has been studied during the intoxication. It has been shown that basal, fluoride,- and 5-guanylyl imidodiphosphate-stimulated AC activity remained unchanged during the intoxication. Stimulation of AC by isoproterenol, glucagon and histamine did not change during the first two hours and significantly decreased after 5 hours of intoxication. Affinity of AC for the investigated hormones did not change through the experiments.
authors.forename: T D
authors.initials: TD
authors.lastname: Cherkasova
authors.forename: V A
authors.initials: VA
authors.lastname: Iurkiv
authors.forename: V P
authors.initials: VP
authors.lastname: Avrorov
authors.forename: A V
authors.initials: AV
authors.lastname: Griboedov
mesh_terms: D000262:Adenylyl Cyclases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D005934:Glucagon / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D009206:Myocardium / Q000201:enzymology*; D010930:Plague / Q000201:enzymology*; D051381:Rats; D012772:Shock, Septic / Q000201:enzymology*; D013268:Stimulation, Chemical; D015010:Yersinia pestis
chemical_list: D006632:Histamine; D005934:Glucagon; D000262:Adenylyl Cyclases; D007545:Isoproterenol
vernacular_title: Reguliatornye svoĭstva adenilattsiklazy serdtsa krys v dinamike chumnogo toksiko-infektsionnogo shoka.