Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats.
The 21-aminosteroid antioxidant tirilazad mesylate (U-74006F) blocks the delayed hypoperfusion associated with spreading cortical depression (SCD) in anesthetized rats. Because the resting vascular tone influences the blood flow response to SCD, the effect of this drug was reassessed in awake rats. In this state, tirilazad mesylate did not eliminate cerebral hypoperfusion following SCD. Oxygen radical-induced lipid peroxidation may not mediate cerebral hypoperfusion after SCD in awake rats.
Duckrow
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RB
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Beard
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DC
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D013181:Cortical Spreading Depression / Q000187:drug effects*; D004558:Electric Stimulation; D008297:Male; D010477:Perfusion; D011281:Pregnatrienes / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014851:Wakefulness / Q000187:drug effects
D000975:Antioxidants; D011281:Pregnatrienes; C053355:tirilazad