title: Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young.
abstract: During our search for a marker for non-insulin-dependent diabetes mellitus (NIDDM) in a large multigenerational family with a form of NIDDM termed maturity-onset diabetes of the young (MODY), we learned a great deal that may serve to streamline the search for diabetes-susceptibility genes in other families. We describe here our experience and suggest strategies that may enhance the search for markers for other diabetes susceptibility genes with genetic linkage approaches.
authors.affiliation: Department of Medicine, University of Chicago, Illinois 60637.
authors.forename: N J
authors.initials: NJ
authors.lastname: Cox
authors.forename: K S
authors.initials: KS
authors.lastname: Xiang
authors.forename: S S
authors.initials: SS
authors.lastname: Fajans
authors.forename: G I
authors.initials: GI
authors.lastname: Bell
mesh_terms: D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005796:Genes / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers; D004247:DNA