Murine ST2 gene is a member of the primary response gene family induced by growth factors.
The murine ST2 gene, which encodes a protein remarkably similar to the extracellular portion of murine interleukin 1 receptor types 1 and 2, is expressed in growth-stimulated BALB/c-3T3 cells in the presence of 50 micrograms/ml of cycloheximide. The treatment with 1,000 U/ml of purified native murine beta-interferon superinduced, rather than suppressed, the ST2 mRNA expression as in the cases of c-myc and JE mRNAs. These results suggested that the murine ST2 gene belongs to the family of primary response genes induced by growth factors. Furthermore, a longer ST2-related mRNA was found in BALB/c-3T3 cells that were stimulated to proliferate in the presence of cycloheximide.
Yanagisawa
K
K
Department of Biochemistry II, Jichi Medical School, Tochigi, Japan.
Tsukamoto
T
T
Takagi
T
T
Tominaga
S
S
D016475:3T3 Cells; D000818:Animals; D015152:Blotting, Northern; D003513:Cycloheximide / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006133:Growth Substances / Q000502:physiology*; D016899:Interferon-beta / Q000502:physiology; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D005810:Multigene Family
D006133:Growth Substances; D016899:Interferon-beta; D003513:Cycloheximide