title: In vitro susceptibility of yeast isolates from the blood to fluconazole and amphotericin B.
abstract: 221 yeast strains including 131 of Candida albicans, 21 of C. tropicals, 23 of C. parapsilosis, 19 of C. glabrata, 7 of C. guilliermondii, 6 of C. krusei and of other species were isolated from the blood. The activity of fluconazole and amphotericin B was investigated by means of a photometer-read broth microdilution method measuring the 30% inhibitory concentrations (IC30). The results of fluconazole showed a higher susceptibility of C. albicans compared to the other species. However, 6 (4.5%) resistant strains of C. albicans were found. Low sensitivity and resistance were evaluated for C. krusei and C. glabrata strains. All isolates showed susceptibility to amphotericin B.
authors.affiliation: Institute of Medical Microbiology, University of Essen, FRG.
authors.forename: H
authors.initials: H
authors.lastname: Dermoumi
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology; D002175:Candida / Q000187:drug effects*; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000666:Amphotericin B; D015725:Fluconazole