The critical role of interleukin-6, interleukin-1B and macrophage colony-stimulating factor in the pathogenesis of bone lesions in multiple myeloma.
Lytic bone lesions and hypercalcemia are common features of multiple myeloma. In contrast, they are exceptional in other B-cell malignancies. Myeloma bone involvement is related to an uncoupling process associating increased osteoclastic resorption with decreased bone formation. Several osteoclast-activating factors, such as interleukin-1, macrophage colony-stimulating factor, and interleukin-6, are involved in this process. However, interleukin-6, the major myeloma cell growth factor, plays a critical role in myeloma-induced bone resorption.
Bataille
R
R
Immunorhumatologie and INSERM U 291, Centre Gui de Chauliac, Hôpital Saint-Eloi, Montpellier, France.
Chappard
D
D
Klein
B
B
D001862:Bone Resorption / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D002116:Calcitonin / Q000627:therapeutic use; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology*; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology*; D009101:Multiple Myeloma / Q000150:complications* / Q000503:physiopathology; D009363:Neoplasm Proteins / Q000502:physiology*; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis; D010014:Osteolysis / Q000209:etiology* / Q000503:physiopathology
D007375:Interleukin-1; D015850:Interleukin-6; D009363:Neoplasm Proteins; D016173:Macrophage Colony-Stimulating Factor; D002116:Calcitonin