title: Repeated coronary artery spasm in a young woman with the eosinophilia-myalgia syndrome.
abstract: We report a case of repeated coronary artery spasm with myocardial injury in a 37-year-old woman with the eosinophilia-myalgia syndrome. This patient did not have a medical history of cardiac-related illness or risk factors for coronary artery disease. The presence of eosinophil granule major basic protein in otherwise normal-appearing myocardial tissue, along with normal plasma levels of tryptophan metabolites, suggests that the mechanism of vasospasm in this patient might involve toxic eosinophil proteins or focal myocardial lesions, but not the production of excess tryptophan metabolites.
authors.affiliation: Los Alamos Medical Center, NM 87544.
authors.forename: P A
authors.initials: PA
authors.lastname: Hertzman
authors.forename: G L
authors.initials: GL
authors.lastname: Maddoux
authors.forename: E M
authors.initials: EM
authors.lastname: Sternberg
authors.forename: M P
authors.initials: MP
authors.lastname: Heyes
authors.forename: I N
authors.initials: IN
authors.lastname: Mefford
authors.forename: G M
authors.initials: GM
authors.lastname: Kephart
authors.forename: G J
authors.initials: GJ
authors.lastname: Gleich
mesh_terms: D000328:Adult; D003329:Coronary Vasospasm / Q000150:complications* / Q000473:pathology; D016603:Eosinophilia-Myalgia Syndrome / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D012008:Recurrence