title: Pathological aspects of Australian Stringhalt.
abstract: Nine horses with clinical signs of Australian Stringhalt were killed and tissues collected for a detailed pathological study. Lesions were limited to peripheral nerves and muscles. The most severely affected nerves were the superficial and deep peroneal, distal tibial, plantar digital, volar and recurrent laryngeal nerve with changes characterised by a selective loss of large diameter myelinated fibres with various degrees of demyelination, fibrosis, Schwann cell proliferation and onion-bulb formation. A routine evaluation of the brain and spinal cord by light microscopy failed to reveal any consistent abnormalities. Morphometric analysis of deep peroneal and recurrent laryngeal nerves confirmed the reduced number of large diameter myelinated axons. Teased fibre preparations of these nerves did not show any abnormalities in internodal distance. The most severe muscle lesions were in the long and lateral digital extensors, cranial tibial, dorsal cricoarytenoid, gracilis and lateral deep digital flexor with extensive atrophy of fibres and diffuse fibrosis. Histochemical evaluation of the long digital extensor from 3 affected horses showed an abnormally wide distribution in fibre size and a reduction in type II fibres compared with controls. These lesions are consistent with a distal axonopathy leading to neurogenic muscle atrophy. The distribution of neuromuscular lesions in Australian Stringhalt may be explained by the susceptibility of longer, larger myelinated nerve fibres to injury, but the cause for this distal axonopathy remains unknown.
authors.affiliation: Veterinary Clinical Centre, University of Melbourne, Victoria, Australia.
authors.forename: R F
authors.initials: RF
authors.lastname: Slocombe
authors.forename: P J
authors.initials: PJ
authors.lastname: Huntington
authors.forename: S C
authors.initials: SC
authors.lastname: Friend
authors.forename: L B
authors.initials: LB
authors.lastname: Jeffcott
authors.forename: A R
authors.initials: AR
authors.lastname: Luff
authors.forename: D K
authors.initials: DK
authors.lastname: Finkelstein
mesh_terms: D000818:Animals; D001284:Atrophy; D001369:Axons / Q000473:pathology / Q000648:ultrastructure; D004196:Disease Outbreaks / Q000662:veterinary; D005260:Female; D006651:Histocytochemistry; D006734:Horse Diseases / Q000473:pathology*; D006736:Horses; D007794:Lameness, Animal / Q000473:pathology*; D007823:Laryngeal Nerves / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000737:chemistry / Q000473:pathology*; D009468:Neuromuscular Diseases / Q000473:pathology / Q000662:veterinary*; D010525:Peripheral Nerves / Q000473:pathology*; D010543:Peroneal Nerve / Q000473:pathology