title: Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura.
abstract: We studied brain and muscle energy metabolism by phosphorus 31 magnetic resonance spectroscopy (31P-MRS) in 12 patients affected by migraine with aura (classic migraine) in interictal periods. Brain 31P-MRS disclosed a low phosphocreatine content in all patients, accompanied by high adenosine diphosphate concentration, a high percentage of V/Vmax (adenosine triphosphate), and a low phosphorylation potential--features showing an unstable state of metabolism in classic migraine. Abnormal muscle mitochondrial function, in the absence of clinical signs of muscle impairment, was present in nine of the 12 patients examined.
authors.affiliation: Cattedra di Biochimica Clinica dell'Università di Bologna, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Barbiroli
authors.forename: P
authors.initials: P
authors.lastname: Montagna
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: R
authors.initials: R
authors.lastname: Funicello
authors.forename: S
authors.initials: S
authors.lastname: Iotti
authors.forename: L
authors.initials: L
authors.lastname: Monari
authors.forename: G
authors.initials: G
authors.lastname: Pierangeli
authors.forename: P
authors.initials: P
authors.lastname: Zaniol
authors.forename: E
authors.initials: E
authors.lastname: Lugaresi
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008881:Migraine Disorders / Q000150:complications* / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009422:Nervous System Diseases / Q000209:etiology*; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D012677:Sensation
chemical_list: D010725:Phosphocreatine; D010758:Phosphorus; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate