title: In vitro uterine contractions in the viviparous lizard Tiliqua rugosa: effects of gestation and steroid pretreatment in vivo.
abstract: Uterine contractility was investigated in the viviparous lizard Tiliqua rugosa. Arginine vasotocin (AVT) induces rhythmic contractions in vitro in strips of uterine tissue from ovariectomized female T. rugosa. The strength of these contractions was related to the dosage of AVT and reduced by pretreatment in vivo with both progesterone and estradiol-17 beta. The frequency of spontaneous and AVT-induced contractions was enhanced by estradiol-17 beta pretreatment. The strength of AVT-induced contractions in pregnant females was not significantly different from that recorded in nonpregnant females. Spontaneous rhythmic contractions were present only in pregnant females. Ovariectomy did not affect either spontaneous or AVT-induced contractions in pregnant females. The data indicate that ovarian steroids modulate uterine contractility in T. rugosa. It is suggested that, following a decline in plasma progesterone levels, estrogen may be involved in the onset of parturition.
authors.affiliation: Department of Zoology, University of Western Australia, Perth.
authors.forename: B
authors.initials: B
authors.lastname: Fergusson
authors.forename: S D
authors.initials: SD
authors.lastname: Bradshaw
mesh_terms: D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008116:Lizards / Q000502:physiology*; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011374:Progesterone / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology*; D014668:Vasotocin / Q000494:pharmacology
chemical_list: D011374:Progesterone; D004958:Estradiol; D014668:Vasotocin