Changes in the coagulation-fibrinolysis balance of endothelial cells and mononuclear phagocytes: role in disseminated intravascular coagulation associated with infectious diseases.
Over the last few years, evidence has accumulated that the pathogenetic mechanism of disseminated intravascular coagulation encountered in patients with infectious diseases is extraordinarily complex and involves multiple interactions between the microorganism itself and/or a number of mediators, both microorganism derived and host manufactured, and multifunctional cellular systems, namely endothelial cells and mononuclear phagocytes. In particular, infectious agents and mediators shift the coagulation-fibrinolysis equilibrium of these cells towards fibrin formation and accumulation, via enhancement of procoagulant properties and reduction of both anticoagulant and fibrinolytic capacities. New insights into the pathogenetic mechanism may have important implications for the management of infected patients with disseminated intravascular coagulation.
Semeraro
N
N
Dipartimento di Scienze Biomediche e Oncologia Umana, University of Bari, Italy.
Colucci
M
M
D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000378:metabolism; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D004285:Dogs; D004730:Endothelium, Vascular / Q000503:physiopathology*; D004731:Endotoxins / Q000009:adverse effects / Q000633:toxicity; D005342:Fibrinolysis; D006801:Humans; D007239:Infections / Q000150:complications; D007963:Leukocytes, Mononuclear / Q000502:physiology; D051379:Mice; D009369:Neoplasms / Q000150:complications / Q000628:therapy; D010215:Papio; D015849:Plasminogen Inactivators / Q000378:metabolism; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D001779:Blood Coagulation Factors; D004731:Endotoxins; D015849:Plasminogen Inactivators; D014409:Tumor Necrosis Factor-alpha; D013917:Thrombin