title: Short report: twenty-four-hour hyperpepsinogenaemia in Helicobacter pylori-positive subjects is abolished by eradication of the infection.
abstract: Twenty-four-hour plasma pepsinogen I and II concentrations were determined in 8 healthy subjects with antibody to Helicobacter pylori, before and after treatment with tripotassium dicitrato bismuthate, amoxycillin and metronidazole, Therapy was successful in the 5 subjects with active H. pylori infection. In these subjects, median integrated 24-h plasma pepsinogen I and II concentrations significantly decreased from 2288 and 357 micrograms.h/L before treatment, respectively, to 1811 and 171 micrograms.h/L at 4-6 weeks after treatment, and 1643 and 150 micrograms.h/L at 20-24 weeks. By contrast, in the 3 subjects without evidence of active H. pylori infection, pre-treatment plasma pepsinogen I and II concentrations were similar to values found in the H. pylori-infected subjects after successful therapy, and they did not change significantly in response to therapy. H. pylori infection is associated with reversible hyperpepsinogenaemia.
authors.affiliation: University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Fraser
authors.forename: E J
authors.initials: EJ
authors.lastname: Prewett
authors.forename: R E
authors.initials: RE
authors.lastname: Pounder
authors.forename: I M
authors.initials: IM
authors.lastname: Samloff
mesh_terms: D000328:Adult; D005260:Female; D016481:Helicobacter Infections / Q000097:blood* / Q000188:drug therapy; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D010435:Pepsinogens / Q000097:blood*; D013997:Time Factors
chemical_list: D010435:Pepsinogens