[IgA nephropathy. Morphology, clinical picture and significance of mesangial fibrin deposits].
IgA nephropathy was diagnosed in 114 biopsies from 107 patients comprising 78% men. Light microscopy revealed most frequently mild proliferative glomerulonephritis with frequent though rudimentary extracapillary proliferation (in one quarter of the biopsies). Allergic manifestations in the case-history were recorded in 14% of the patients. Almost in one third of the patients the disease started by macroscopic erythrocyturia. A typical finding in urine was predominating erythrocyturia (tens of millions in Addis sediment) over proteinuria (usually less than 1.5 g/24 h). Cumulative "renal survival rate" ten year after biopsy was 84%, the cumulative ratio of remissions was 30%. Mesangial fibrinoid deposits were found in half the patients with a severe course of the condition.
Matousovic
K
K
Klinika nefrologie, Institutu klinické a experimentální medicíny, Praha.
Rossmann
P
P
Skibová
J
J
Drevíkovská
J
J
D000328:Adult; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005920:Glomerular Mesangium / Q000378:metabolism*; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007668:Kidney / Q000473:pathology; D008297:Male
D007136:Immunoglobulins; D005337:Fibrin
IgA nefropatie. Morfologie, klinický obraz a význam mesangiálních ulozenin fibrinoidu.