Effects of chronic ethanol consumption on the rat parotid gland.
Two-month-old Wistar rats ingested 10% ethanol for 12 months. Their parotid glands were then compared with those of normal controls by light microscopy. They had extensive ductal and acinar oncocytic transformation; numerous atypical acinar cells showed anisocytosis, polyploidism and hyperchromatism, features that were absent in controls. Oncocytosis and atypical acinar cells have been reported in 2-3-yr-old ('senile') Wistar rats. Thus, chronic alcohol ingestion may produce cellular features resembling those observed in the parotid gland of 'senile' Wistar rats.
Banderas
J A
JA
Department of Oral Pathology, School of Dental Medicine, National Autonomous University of Mexico, Mexico City.
Gaitan
L A
LA
Portilla
J
J
Aguirre
A
A
D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D002843:Chromatin / Q000187:drug effects / Q000648:ultrastructure; D003238:Connective Tissue / Q000187:drug effects / Q000473:pathology; D003593:Cytoplasm / Q000187:drug effects / Q000648:ultrastructure; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005355:Fibrosis; D008679:Metaplasia; D010306:Parotid Gland / Q000187:drug effects / Q000473:pathology*; D011123:Polyploidy; D051381:Rats; D011919:Rats, Inbred Strains
D002843:Chromatin; D000431:Ethanol