title: Regional cerebral blood flow after long-term exposure to carbon disulfide.
abstract: Sixteen former rayon viscose workers were investigated four years after the exposure to carbon disulfide was discontinued. Median age was 58 years (range 43-65 years), median exposure time was 17 years (range 10-35 years). Encephalopathy was diagnosed in altogether 14 workers. To further explore pathophysiological mechanisms, cerebrovascular investigations were employed. Doppler ultrasound examination of the precerebral vessels in 15 workers showed a slight stenosis of the left internal carotid artery in one. Regional cerebral blood flow investigation (rCBF) with single photon emission computerized tomography (SPECT) with Xenon-133 gas was performed in 14. There was no significant difference from a control group. Regional side-to-side asymmetries beyond reference limits were demonstrated in eight workers. The abnormalities were modest, but may indicate a tendency toward focal blood flow disturbances in workers with long-term exposure to carbon disulfide.
authors.affiliation: Department of Neurology, Rikshospitalet, Oslo, Norway.
authors.forename: O
authors.initials: O
authors.lastname: Aaserud
authors.forename: D
authors.initials: D
authors.lastname: Russell
authors.forename: R
authors.initials: R
authors.lastname: Nyberg-Hansen
authors.forename: K
authors.initials: K
authors.lastname: Rootwelt
authors.forename: E B
authors.initials: EB
authors.lastname: Jörgensen
authors.forename: P
authors.initials: P
authors.lastname: Nakstad
authors.forename: O J
authors.initials: OJ
authors.lastname: Hommeren
authors.forename: B
authors.initials: B
authors.lastname: Tvedt
authors.forename: L
authors.initials: L
authors.lastname: Gjerstad
mesh_terms: D000328:Adult; D001921:Brain / Q000098:blood supply*; D001925:Brain Damage, Chronic / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002246:Carbon Disulfide / Q000506:poisoning*; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004453:Echoencephalography; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D016273:Occupational Exposure; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002246:Carbon Disulfide