Smoking and risk of leukemia.
The relation between tobacco use and leukemia was evaluated in a population-based case-control study of 578 white men with leukemia and 820 controls conducted in Iowa and Minnesota during 1981-1984. Risks were significantly elevated for all leukemia (odds ratio (OR) = 1.4) and chronic lymphocytic leukemia (OR = 1.6) for both tobacco users and cigarette smokers. There were significantly elevated risks for cigarette smokers of longest duration for all leukemia (OR = 1.6), chronic myelogenous leukemia (OR = 3.3), and chronic lymphocytic leukemia (OR = 1.6). Thus, the findings of this study provide additional support for an association between smoking and the risk of several types of leukemia.
Brown
L M
LM
Epidemiology and Biostatistics Program, National Cancer Institute, Bethesda, MD 20892.
Gibson
R
R
Blair
A
A
Burmeister
L F
LF
Schuman
L M
LM
Cantor
K P
KP
Fraumeni
J F
JF
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D006801:Humans; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010947:Plants, Toxic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D014030:Tobacco, Smokeless / Q000009:adverse effects