title: Anti-AIDS agents, 4. Tripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation.
abstract: A new kaurane-type diterpene lactone, tripterifordin [1], has been isolated from the roots of Tripterygium wilfordii. The structure of 1 was elucidated by spectroscopic methods, including the concerted application of a number of 2D nmr techniques that involved the 1H-1H COSY, heteronucleus-detected variants of the heteronuclear chemical shift correlation (HETCOR), phase-sensitive NOESY, and long-range HETCOR. Compound 1 shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.
authors.affiliation: Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: Q A
authors.initials: QA
authors.lastname: Shi
authors.forename: T
authors.initials: T
authors.lastname: Fujioka
authors.forename: D C
authors.initials: DC
authors.lastname: Zhang
authors.forename: C Q
authors.initials: CQ
authors.lastname: Hu
authors.forename: J Q
authors.initials: JQ
authors.lastname: Jin
authors.forename: R E
authors.initials: RE
authors.lastname: Kilkuskie
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; C074970:tripterifordin