A lumped parameter mathematical model of the splanchnic circulation.
A lumped parameter mathematical model to describe the propulsion of blood in the splanchnic circulation was developed by integrating the principles of mechanics and physiology. A set of governing equations by derived by specifically considering the contractility of the portal vein, hepatic vein, liver sinusoids, and of the draining lymphatics. These equations were then simulated on a computer. The present simulation results substantiate previous experimental observations that hepatic venous pressure leads to portal hypertension and increased liver interstitial fluid volume.
Chu
T M
TM
Department of Biomedical Engineering, University of Akron, Ohio 44325.
Reddy
N P
NP
D001794:Blood Pressure; D003198:Computer Simulation; D008955:Models, Cardiovascular; D013152:Splanchnic Circulation / Q000502:physiology*; D013314:Stress, Mechanical; D014682:Vena Cava, Inferior / Q000502:physiology