title: A new bradykinin-potentiating peptide (peptide P) isolated from the venom of Bothrops jararacussu (jararacuçu tapete, urutu dourado).
abstract: Several bradykinin potentiators were identified in the venom of Bothrops jararacussu by chromatographic techniques and biological assays. One of them which was isolated inhibited the angiotensin-converting enzyme in vitro and potentiated the bradykinin-induced lowering of the arterial pressure in the rat.
authors.affiliation: Serviço de Bioquímica-Lab, Cininas, Instituto Butantan, São Paulo, Brazil.
authors.forename: L A
authors.initials: LA
authors.lastname: Ferreira
authors.forename: O B
authors.initials: OB
authors.lastname: Henriques
authors.forename: I
authors.initials: I
authors.lastname: Lebrun
authors.forename: M B
authors.initials: MB
authors.lastname: Batista
authors.forename: B C
authors.initials: BC
authors.lastname: Prezoto
authors.forename: A S
authors.initials: AS
authors.lastname: Andreoni
authors.forename: R
authors.initials: R
authors.lastname: Zelnik
authors.forename: G
authors.initials: G
authors.lastname: Habermehl
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000494:pharmacology*; D002216:Captopril / Q000494:pharmacology; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003435:Crotalid Venoms / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D007082:Ileum; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009924:Organ Culture Techniques; D051381:Rats; D012911:Snakes
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D003435:Crotalid Venoms; D009842:Oligopeptides; C006791:bradykinin potentiating factors; D002216:Captopril; D001920:Bradykinin