[The effect of verapamil on left ventricular diastolic function in coronary heart disease].
Echocardiography was performed on 21 patients (6 women, 15 men; mean age 52 [40-68] years) with coronary heart disease (at least 75% stenosis), before and after taking 80 or 120 mg verapamil, to test the drug's acute effect on left-ventricular (LV) relaxation and filling. After taking 80 mg verapamil the only significant (P less than 0.05) decrease was in the proportion of isovolumetric relaxation time to cardiac cycle. The echocardiographic changes were significantly (P less than 0.01) greater after 120 mg than 80 mg: Isovolumetric relaxation time decreased by 13 and 4%, respectively, flow integral of early diastolic LV filling (E wave) increased by 17 and 2%, and atrial filling fraction (atrial component of LV filling) fell by 14 and 2%. Apparently verapamil has a positive effect on the energetically important early diastolic relaxation of the left ventricle. Thus diastolic abnormalities of LV function in patients with coronary heart disease are not fixed but can be at least partially improved with verapamil.
Störk
T
T
Abteilung für Kardiologie, Klinikum Rudolf Virchow, Berlin.
Möckel
M
M
Piske
G
G
Eichstädt
H
H
Müller
R
R
Hochrein
H
H
D000328:Adult; D000368:Aged; D002306:Cardiac Volume / Q000187:drug effects / Q000502:physiology; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D003971:Diastole / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D014700:Verapamil
Einfluss von Verapamil auf die diastolische Funktion des linken Ventrikels bei koronarer Herzkrankheit.