title: Myocardial contrast echocardiography: influence of ischaemia and hyperaemia in an animal model.
abstract: To evaluate changes in myocardial contrast echocardiography during ischaemia and hyperaemia, contrast studies were performed in 16 open chest dogs. Time-intensity curves were generated using videodensitometry after contrast injections to demonstrate ischaemic and non-ischaemic areas of interest during a wide range of coronary blood flow levels. For each time-intensity curve, the peak contrast intensity (PCI), washout halftime (T1/2) and area under the curve (AUC) were calculated. PCI and AUC decreased significantly only with severe ischaemia (90% or more reduction in flow), and increased significantly with hyperaemia of more than 2.5 times baseline flow. Both ischaemia and hyperaemia were found to prolong the T1/2. There was only a moderate linear correlation between the magnitude of hyperaemia and myocardial contrast echocardiographic parameters. There was significantly less increase in myocardial contrast echocardiographic parameters during hyperaemia in segments supplied by a stenosed coronary artery.
authors.affiliation: Department of Medicine, University of Rochester, NY.
authors.forename: S A
authors.initials: SA
authors.lastname: Reisner
authors.forename: S
authors.initials: S
authors.lastname: Gottlieb
authors.forename: A
authors.initials: A
authors.lastname: Ernst
authors.forename: J R
authors.initials: JR
authors.lastname: Shapiro
authors.forename: R
authors.initials: R
authors.lastname: Beyar
authors.forename: W
authors.initials: W
authors.lastname: Markiewicz
authors.forename: R S
authors.initials: RS
authors.lastname: Meltzer
mesh_terms: D000418:Albumins; D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004285:Dogs; D004452:Echocardiography / Q000379:methods; D006940:Hyperemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008954:Models, Biological
chemical_list: D000418:Albumins; D003287:Contrast Media