FMH-induced decrease in central histamine levels produces increased feeding and body weight in rats.
The present study tested the long-term effects of the histamine (H) synthesis inhibitor alpha-fluoromethylhistidine (FMH) on feeding and body weight in rats. FMH (administered via 2-week osmotic minipumps) increased feeding significantly throughout the test period. Body weights were also significantly increased toward the end of the test period. Hypothalamic H assays, performed at the end of the study, confirmed that FMH-treated rats had significantly lower H levels than controls. In general, the results suggest that H activity and feeding are inversely related.
Orthen-Gambill
N
N
Tufts University, Medford, MA 02155.
Salomon
M
M
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D006632:Histamine / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008762:Methylhistidines; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D006640:Histidine Decarboxylase