The plasticity of cutaneous hyperalgesia during sympathetic ganglion blockade in patients with neuropathic pain.
In order to investigate the plasticity of cutaneous sensory abnormalities in neuropathic pain, we monitored sensory and vasomotor effects of diagnostic sympathetic ganglion blocks in 24 patients, who suffered from chronic pain and cutaneous hyperalgesia following peripheral nerve or tissue injury. Ongoing pain was rated on a visual analogue scale, and pain evoked by innocuous tactile and cooling stimuli (hyperalgesia) on a verbal rating scale. Skin temperatures were determined at symmetric sites. In two patients, cutaneous blood flow was measured with a laser Doppler device. The sympathetic blocks led to a significant reduction of the group mean ongoing pain (40%) and cutaneous hyperalgesia (50%). Between patients, however, there was a large variability that could not be related merely to adequacy of sympathetic blockade. Neither the magnitude of change in skin temperature nor the final skin temperature after the block correlated with the amount of pain relief. The relief of hyperalgesia, however, correlated with the relief of ongoing pain. Nine patients experienced pain relief of greater than 50%. In these patients, the time course of hyperalgesia relief was similar to the time course of relief of ongoing pain. Pain relief occurred simultaneously with or a few minutes before cutaneous vasodilatation. During the block, even vigorous mechanical or cold stimuli did not rekindle hyperalgesia. In all patients, pain and hyperalgesia returned within a day after the block. In three patients tested, passive warming of the limb to the temperature achieved by the sympathetic block had negligible effects on pain and hyperalgesia. The hyperalgesia of sympathetically maintained pain is thought to be due to sensitization of central pain-signalling neurons to mechanoreceptor input. The present data indicate that this sensitization is highly plastic even when the disease has persisted for months or years. It could be reversed within minutes by a sympathetic blockade, but returned when sympathetic block subsided. Mechanoreceptor input by itself was not sufficient to maintain or rekindle the central sensitization. This supports the hypothesis that low-grade activity of nociceptors, possibly due to development of alpha-adrenergic sensitivity after injury, is involved in the maintenance of central sensitization.
Treede
R D
RD
Department of Neurosurgery, Johns Hopkins University, Baltimore.
Davis
K D
KD
Campbell
J N
JN
Raja
S N
SN
D000328:Adult; D005260:Female; D005728:Ganglia, Sympathetic / Q000503:physiopathology*; D006801:Humans; D006930:Hyperalgesia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D009422:Nervous System Diseases / Q000503:physiopathology*; D009473:Neuronal Plasticity; D010146:Pain / Q000503:physiopathology; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply; D012871:Skin Diseases / Q000503:physiopathology*; D012881:Skin Temperature; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013997:Time Factors