title: Role of the distal pancreas in pancreatic polypeptide release.
abstract: In two previous studies, postprandial pancreatic polypeptide (PP) release was inhibited when pancreatic denervation was combined with distal pancreatectomy. In contrast, postprandial PP release was unaffected by pancreatic denervation without a distal pancreatectomy. These findings suggested a role for the distal pancreas in regulation of postprandial PP release. To examine this possibility, we performed distal pancreatectomy on four mongrel dogs. Pancreatic polypeptide response to i.v. insulin (0.5 U/kg), a meal, and an infusion of cholecystokinin octapeptide (CCK-8; 50 ng/kg/h) were measured in conscious dogs before and after distal pancreatectomy. Insulin-induced hypoglycemia stimulated PP release both preoperatively (47.0 +/- 8.8 ng.[0-120]min/ml) and postoperatively (61.6 +/- 9.2 ng.[0-120]min/ml). Ingestion of a meal also evoked significant PP release preoperatively (85.8 +/- 22.1 ng.[0-180]min/ml) and postoperatively (105.8 +/- 42.2 ng.[0-180]min/ml). CCK-8 elicited only a small increase in circulating PP, which was not influenced by distal pancreatectomy. These findings demonstrate that distal pancreatectomy does not alter PP response to insulin, a meal, or CCK-8.
authors.affiliation: Department of Surgery, University of Cincinnati, Ohio.
authors.forename: B W
authors.initials: BW
authors.lastname: Kuvshinoff
authors.forename: A R
authors.initials: AR
authors.lastname: DeMar
authors.forename: T W
authors.initials: TW
authors.lastname: Gettys
authors.forename: I L
authors.initials: IL
authors.lastname: Taylor
authors.forename: A S
authors.initials: AS
authors.lastname: Fink
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D004435:Eating / Q000502:physiology; D007003:Hypoglycemia / Q000097:blood; D010179:Pancreas / Q000502:physiology*; D010191:Pancreatic Polypeptide / Q000378:metabolism*; D012844:Sincalide / Q000097:blood
chemical_list: D001786:Blood Glucose; D010191:Pancreatic Polypeptide; D012844:Sincalide