title: Angiosarcoma of the thigh with thrombosis in the femoral artery.
abstract: We report a case of angiosarcoma with some peculiar clinical features developing on the left thigh of a 63-year-old man. The early primary lesion was erythematous with necrotic areas. The initial biopsy specimen of the lesion indicated a benign angioproliferative process. However, the necrotic area enlarged rapidly, ulcerated with severe pain, and thus was widely excised. The excised specimen had a malignant histologic appearance, particularly in the fascia, and was diagnosed as angiosarcoma. Following local recurrence, the lesion was complicated by thrombosis of the femoral artery at the affected site. A similar cutaneous lesion subsequently arose on the right lower leg, and thrombosis developed in the right femoral artery. Both legs had to be amputated. There were no distant metastases.
authors.affiliation: Department of Dermatology, Tsuyama Central Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: K
authors.initials: K
authors.lastname: Iwasaki
authors.forename: E
authors.initials: E
authors.lastname: Mishima
authors.forename: S
authors.initials: S
authors.lastname: Shimao
authors.forename: H
authors.initials: H
authors.lastname: Miyamoto
mesh_terms: D000671:Amputation, Surgical; D005263:Femoral Artery; D006394:Hemangiosarcoma / Q000150:complications* / Q000648:ultrastructure; D006801:Humans; D007866:Leg / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D012878:Skin Neoplasms / Q000150:complications* / Q000648:ultrastructure; D013848:Thigh; D013927:Thrombosis / Q000209:etiology*