title: Levels of fusidic acid in skin blister fluid and serum after repeated administration of two dosages (250 and 500 mg).
abstract: The fusidic acid steady-state concentrations in serum (S) and skin suction blister fluid (SBF) after oral doses of 250 and 500 mg administered twice daily for 6 days, as film-coated tablets of sodium fusidate, were studied in eight healthy subjects. The mean peak serum concentrations after the 250- and 500- mg regimens were 39 +/- 5 and 102 +/- 11 mg/l, respectively, obtained between 2 and 3 h after drug intake. The corresponding values for SBF, obtained later, between 2 and 12 h after drug intake, were 21 +/- 5 and 79 +/- 11 mg/l. As measured by the ratio of area under the concentration vs. time curve (SBF/S), fusidic acid penetration is 69-75%, whatever the dose. With either regime, the fusidic acid SBF and serum levels exceed the minimal inhibitory concentration of bacteria usually found in skin infections, especially Staphylococcus species. A dose of 250 mg twice a day appears sufficient to treat these infections and could be tested in clinical studies.
authors.affiliation: Service de Dermatologie, CHU Trousseau, Tours, France.
authors.forename: L
authors.initials: L
authors.lastname: Vaillant
authors.forename: L
authors.initials: L
authors.lastname: Machet
authors.forename: A M
authors.initials: AM
authors.lastname: Taburet
authors.forename: H
authors.initials: H
authors.lastname: Sorensen
authors.forename: G
authors.initials: G
authors.lastname: Lorette
mesh_terms: D000328:Adult; D001768:Blister / Q000378:metabolism*; D001826:Body Fluids / Q000737:chemistry*; D004334:Drug Administration Schedule; D005260:Female; D005672:Fusidic Acid / Q000032:analysis* / Q000097:blood / Q000494:pharmacology; D006801:Humans; D008297:Male
chemical_list: D005672:Fusidic Acid