[Immunologic studies in patients with dilated cardiomyopathy].
In 10 cases of dilated cardiomyopathy the HLA-loci (A, B, C, DR) and marker expression on lymphocytes were studied. In this group the T4/T8-ratio was decreased and interleukin-2-expression was increased in relation to normals or patients with chronic coronary heart disease, respectively. 9 patients had the HLA-A1 or HLA-A2-locus in their siblings. In correlation analysis between immunological and hemodynamic parameters a good correlation of the number of NK-cells to the ejection fraction (r = 0.79) and negative correlation of helpercells (CD4) to the cardiac output were found (r = -0.80). The results of this attempt suggest an immunological pathogenesis of the dilated cardiomyopathy.
Vogt
S
S
Klinik für Herz- und Gefässchirurgie, Sektion Biowissenschaften der Universität Leipzig.
Ewers
P
P
Goos
H
H
Krosse
B
B
Löbe
M
M
Ladusch
M
M
Seim
K
K
Wolff
M
M
D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D002311:Cardiomyopathy, Dilated / Q000276:immunology* / Q000473:pathology; D004562:Electrocardiography; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology
D015703:Antigens, CD; D006680:HLA Antigens
Immunologische Untersuchungen bei Patienten mit dilatativer Kardiomyopathie.