title: Temporal lobectomy for seizures associated with unilateral schizencephaly.
abstract: Schizencephaly is characterized by unilateral or bilateral cerebral clefts associated with neurologic deficits and epilepsy. Most commonly schizencephaly is attributed to abnormal neuronal migration, and these malformations are well visualized by current neuroimaging techniques. This report describes a patient with unilateral schizencephaly and poorly controlled complex partial seizures who was found to have a temporal lobe seizure focus; anterior temporal lobectomy produced nearly complete control of the seizures. Despite the extensive malformation, relatively restricted resection was of significant benefit. The principles of seizure focus localization and resection are applicable to the management of patients with schizencephaly.
authors.affiliation: Department of Neurological Surgery, University of Miami School of Medicine, Florida.
authors.forename: H J
authors.initials: HJ
authors.lastname: Landy
authors.forename: R E
authors.initials: RE
authors.lastname: Ramsay
authors.forename: C
authors.initials: C
authors.lastname: Ajmone-Marsan
authors.forename: B E
authors.initials: BE
authors.lastname: Levin
authors.forename: J
authors.initials: J
authors.lastname: Brown
authors.forename: G
authors.initials: G
authors.lastname: Pasarin
authors.forename: R M
authors.initials: RM
authors.lastname: Quencer
mesh_terms: D000328:Adult; D001921:Brain / Q000002:abnormalities*; D002547:Cerebral Palsy / Q000150:complications; D004827:Epilepsy / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery*