title: Regulation of the expression of adhesion molecules by human synoviocytes.
abstract: The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1 beta greater than tumor necrosis factor-alpha, interferon-gamma much greater than interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.
authors.affiliation: Department of Medicine, University of Kansas Medical Center, Kansas City.
authors.forename: H B
authors.initials: HB
authors.lastname: Lindsley
authors.forename: D D
authors.initials: DD
authors.lastname: Smith
authors.forename: L S
authors.initials: LS
authors.lastname: Davis
authors.forename: A E
authors.initials: AE
authors.lastname: Koch
authors.forename: P E
authors.initials: PE
authors.lastname: Lipsky
mesh_terms: D015815:Cell Adhesion Molecules / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D013583:Synovial Membrane / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules