title: [Changes in dynamic respiratory volumes in obese children and adolescents related to weight loss and sex].
abstract: Obesity is associated with various alterations in lung function in adults. These alterations appear to be proportional to the degree of EP and the beneficial effect of weight loss on respiratory function has been reported. Therefore, in 35 children and adolescents affected by essential obesity of medium-severe degree, we have evaluated the following parameters: FVC (forced vital capacity), PEF (peak expiratory flow), FEV1 (forced expiratory volume), FEV75, FEV50, FEV25, before and after six months of dieting. Twelve subjects (34%) showed at least a pathologic value of PEF and/or FEV50 before dieting. All the female patients normalized their parameters after six months of dieting, whilst 5 out of 7 males still showed pathologic respiratory indexes, although a similar weight loss was obtained in the two groups of patients. Our study enhances the presence of respiratory functions derangements in a significant percentage of children with medium-severe degree of obesity. A careful monitoring of these subjects is therefore necessary, in order to prevent further progression of the lung function damage. After dieting the pulmonary function improved in female patients only, suggesting that factors other than the EP are involved in the pathogenesis of the respiratory alterations.
authors.affiliation: Istituto Scientifico H San Raffaele, Università degli Studi di Milano.
authors.forename: P
authors.initials: P
authors.lastname: Brambilla
authors.forename: A F
authors.initials: AF
authors.lastname: D'Arcais
authors.forename: M P
authors.initials: MP
authors.lastname: Guarneri
authors.forename: G
authors.initials: G
authors.lastname: Rondanini
authors.forename: F
authors.initials: F
authors.lastname: Righetti
authors.forename: L
authors.initials: L
authors.lastname: Bosio
authors.forename: D
authors.initials: D
authors.lastname: Cella
authors.forename: G
authors.initials: G
authors.lastname: Chiumello
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D012119:Respiration; D012129:Respiratory Function Tests; D012737:Sex Factors; D015431:Weight Loss
vernacular_title: Variazioni dei volumi respiratori dinamici in bambini ed adolescenti obesi in relazione al dimagrimento ed al sesso.