Interaction of interleukin 2 and interleukin 4 during LAK cell generation.
Immunoregulatory lymphokines IL-2 and IL-4 produced by IL-2- and IL-4-cDNA-transformed somatic cells were used for LAK cell generation. The cytolytic effect of LAK cells activated for 3 days with IL-2 and measured by 51Cr release of three types of target cells, YAC-1 (NK-sensitive), C1498 (NK-resistant) and X63-Ag8.563 (plasmocytoma cell line utilized for insertion of the IL-2 and IL-4 genes), was significantly depressed by adding IL-4 during the activation period.
Indrová
M
M
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Jandlová
T
T
Bubeník
J
J
D000818:Animals; D003602:Cytotoxicity, Immunologic; D007376:Interleukin-2 / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011994:Recombinant Proteins / Q000276:immunology; D014407:Tumor Cells, Cultured
D007376:Interleukin-2; D011994:Recombinant Proteins; D015847:Interleukin-4