title: Lipid droplets of neuroepithelial cells are a major calcium storage site during neural tube formation in chick and mouse embryos.
abstract: In situ precipitation of calcium (Ca2+) with fluoride and antimonate shows that Ca(2+)-specific precipitate is localized almost exclusively within lipid droplets of neuroepithelial cells during neural tube formation in chick and mouse embryos. The density of Ca2+ precipitate within lipid droplets is generally greater in the apical ends of cells situated in regions of the neuroepithelium that are actively engaged in bending. These findings suggest that lipid droplets, in addition to providing a source of metabolic fuel for developing neuroepithelial cells, also serve as Ca(2+)-storage and -releasing sites during neurulation.
authors.affiliation: Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford 08084.
authors.forename: K T
authors.initials: KT
authors.lastname: Bush
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: R G
authors.initials: RG
authors.lastname: Nagele
mesh_terms: D000818:Animals; D000965:Antimony; D002118:Calcium / Q000378:metabolism*; D002490:Central Nervous System / Q000196:embryology* / Q000378:metabolism; D011232:Chemical Precipitation; D002642:Chick Embryo; D003594:Cytoplasmic Granules / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D005459:Fluorides; D050356:Lipid Metabolism; D051379:Mice; D008854:Microscopy, Electron
chemical_list: D000965:Antimony; D005459:Fluorides; D002118:Calcium