The methyltrienolone binding protein of JEG-3 cells and human placenta is localized within the nucleus and is tightly associated with chromatin.
Human placenta contains the methyltrienolone binding protein (MTBP), an androgen binding protein which is distinct from the androgen receptor. This study demonstrates that the human choriocarcinoma cell line (JEG-3) also contains the MTBP and that in both human placenta and JEG-3 cells the MTBP is located exclusively in the nucleus and in particular is associated with DNase 1 resistant chromatin.
Macaulay
J O
JO
Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, Australia.
Warne
G L
GL
Krozowski
Z S
ZS
D000727:Androgen-Binding Protein / Q000378:metabolism*; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism; D002822:Choriocarcinoma; D002843:Chromatin / Q000378:metabolism; D006801:Humans; D015741:Metribolone / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010920:Placenta / Q000378:metabolism* / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
D000727:Androgen-Binding Protein; D002843:Chromatin; D009687:Nuclear Proteins; C028867:methyltrienolone binding protein, human; D015741:Metribolone