title: Acquired von Willebrand disease: correction of hemostatic defect by high-dose intravenous immunoglobulins.
abstract: High-dose intravenous immunoglobulins (ivIG) were used in a 57-year-old patient with acquired von Willebrand disease in order to correct a hemostatic defect before pneumonectomy for lung carcinoma. IvIG induced a rapid and complete correction of factor VIII (F VIII) and von Willebrand factor (vWF) and allowed surgery without additional factor coverage. F VIII and vWF returned to baseline values within 10 days after ivIG.
authors.affiliation: Service d'Hématologie, Hôtel-Dieu, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Delmer
authors.forename: M H
authors.initials: MH
authors.lastname: Horellou
authors.forename: J M
authors.initials: JM
authors.lastname: Bréchot
authors.forename: J
authors.initials: J
authors.lastname: Prudent
authors.forename: F
authors.initials: F
authors.lastname: Potevin
authors.forename: C
authors.initials: C
authors.lastname: Lecrubier
authors.forename: C
authors.initials: C
authors.lastname: Girard-Longhini
authors.forename: M
authors.initials: M
authors.lastname: Samama
authors.forename: R
authors.initials: R
authors.lastname: Zittoun
mesh_terms: D004305:Dose-Response Relationship, Drug; D005169:Factor VIII / Q000032:analysis; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014842:von Willebrand Diseases / Q000097:blood / Q000188:drug therapy*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D016756:Immunoglobulins, Intravenous; D014841:von Willebrand Factor; D005169:Factor VIII