Asthma: cells and cytokines.
The pathology of bronchial asthma demonstrates a multicellular process. In an attempt to elucidate the cellular biology of airways inflammation, it becomes important to understand not only the biology of each individual cell type but also the interaction between different cells. This review focuses on a documentation of some of the biological effects of the constituent cells in the airway mucosa and a discussion of their potential interactions through the release and action of different cytokines. It seems likely that future research will address the in vivo release of different cytokine molecules in the asthmatic process using techniques of molecular biology. There likely will be increasing information available about the regulation and the actions of these molecules on target cells and tissues. Elucidation of some of the complex interactions between different cells and the role of different cytokine molecules may provide a novel approach to the therapy of bronchial asthma.
Litchfield
T M
TM
Department of Allergy and Allied Respiratory Disorders, U.M.D.S. Guy's Hospital, London, England.
Lee
T H
TH
D000818:Animals; D001249:Asthma / Q000473:pathology* / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology*; D004804:Eosinophils / Q000502:physiology; D004848:Epithelium / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008264:Macrophages / Q000502:physiology; D008407:Mast Cells / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D016207:Cytokines