title: Postnatal development of parvalbumin immunoreactivity in axon terminals of basket and chandelier neurons in monkey neocortex.
abstract: 1. Two classes of GABAergic inhibitory interneurons, chandelier and basket cells, are known regulators of pyramidal neurons. Parvalbumin (PV) a calcium binding protein, has been shown to be a marker for axon terminals of subpopulations of these interneurons. 2. Immunohistochemical methods were used in this study to examine changes in the distribution of PV-immunoreactive (IR) chandelier and basket axon terminals during postnatal development of monkey neocortex. 3. Our results indicate a differential effect of postnatal development on PV-IR axon terminals of chandelier and basket neurons that is region-specific. 4. The differential regional, laminar and developmental pattern of PV-IR axon terminals of chandelier and basket cells may provide insight into the functional role of these classes of inhibitory neurons in primate neocortex.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, PA 15213.
authors.forename: M
authors.initials: M
authors.lastname: Akil
authors.forename: D A
authors.initials: DA
authors.lastname: Lewis
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001369:Axons / Q000276:immunology / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D005625:Frontal Lobe / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D007150:Immunohistochemistry; D007395:Interneurons / Q000276:immunology / Q000378:metabolism; D008253:Macaca mulatta; D009411:Nerve Endings / Q000276:immunology / Q000378:metabolism*; D009474:Neurons / Q000276:immunology / Q000378:metabolism*; D010320:Parvalbumins / Q000276:immunology / Q000378:metabolism*; D014793:Visual Cortex / Q000166:cytology / Q000276:immunology / Q000378:metabolism
chemical_list: D010320:Parvalbumins