title: Proteasomes are regulated by interferon gamma: implications for antigen processing.
abstract: Class I major histocompatibility complex (MHC) molecules present antigenic peptides of cytoplasmic origin to T cells. As the lengths of these peptides seem restricted to eight or nine amino acids, an unusual proteolytic system must play a role in antigen processing. Proteasomes, a major extralysosomal proteolytic system, are responsible for the degradation of cytoplasmic proteins. We demonstrate that several proteasomal subunits, including MHC-encoded subunits, are regulated by interferon gamma. These data and the finding that MHC-encoded and other interferon gamma-regulated proteasomal subunits are uniquely associated with proteasomes strongly suggest that the immune system has recruited proteasomes for antigen processing.
authors.affiliation: Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: J B
authors.initials: JB
authors.lastname: Waters
authors.forename: K
authors.initials: K
authors.lastname: Früh
authors.forename: P A
authors.initials: PA
authors.lastname: Peterson
mesh_terms: D000818:Animals; D000941:Antigens / Q000378:metabolism*; D002451:Cell Compartmentation; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D006367:HeLa Cells; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D007526:Isoelectric Point; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D051379:Mice; D008970:Molecular Weight; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex
chemical_list: D000941:Antigens; D046911:Macromolecular Substances; D009097:Multienzyme Complexes; D007371:Interferon-gamma; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex