title: Interleukin-1 beta and interleukin-6 mRNA are expressed in human glioblastoma and neuroblastoma cells respectively.
abstract: We report the expression of different interleukins (IL) in four human glioblastoma and neuroblastoma cell lines. The glioblastoma cell line LI, expresses IL-1 beta and IL-6 mRNA, though not IL-2 and IL-4. The expression of the former gene is modulated by retinoic acid. Two cell clones [BE(2)-C and BE(2)-M17] as well as the neuroblastoma cell line SK-N-BE(2), from which both clones were derived, express IL-6 mRNA, but not IL-1 beta, IL-2 or IL-4. Both IL-1 beta and IL-6 cytokines are known to increase hypothalamic CRH mRNA, a gene reported to be expressed in all these cell lines. The production of both cytokines and neuropeptides indicates a complex dialogue between tumour cells and anti-tumour immunity.
authors.affiliation: Department of Neuroendocrinology, Charing Cross Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Stephanou
authors.forename: R A
authors.initials: RA
authors.lastname: Knight
authors.forename: M
authors.initials: M
authors.lastname: Annicchiarico-Petruzzelli
authors.forename: A
authors.initials: A
authors.lastname: Finazzi-Agrò
authors.forename: S L
authors.initials: SL
authors.lastname: Lightmann
authors.forename: G
authors.initials: G
authors.lastname: Melino
mesh_terms: D015152:Blotting, Northern; D001932:Brain Neoplasms / Q000378:metabolism; D002460:Cell Line; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000235:genetics; D015850:Interleukin-6 / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D009447:Neuroblastoma / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis*; D014407:Tumor Cells, Cultured
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D012333:RNA, Messenger