title: [Glucose tolerance in the elderly--changes in insulin, C-peptide and glucagon secretion].
abstract: The OGTT has been carried out by the authors with 25 older individuals (age 82 +/- 5.1) and 14 younger persons (age 28 +/- 9.0) who all showed neither clinical nor laboratory symptoms of apparent diabetes. During the test authors were determining venose glycaemia, insulin, C-peptide, glucagone and they computed some mathematical quantities enabling the estimation of the insulin secretion. The course of the OGTT of the older group showed higher values of glycaemia, insulin and C-peptide since the 60th minute tending to a duration or to a slow decline (up to the 120th minute). A significant difference in the glucagone values was found by the authors only in the case of fasting higher with the older ones (p = 0.01). The estimation of insulin secretion in the early phase of the OGTT was found by the authors significantly higher with the younger ones in both times.
authors.affiliation: I. Internen Klinik, Universitätskrankenhauses Brno-Bohunice, Tschechoslowakei.
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: I
authors.initials: I
authors.lastname: Kolácný
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D002096:C-Peptide / Q000097:blood*; D005260:Female; D005934:Glucagon / Q000097:blood*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D012016:Reference Values
chemical_list: D002096:C-Peptide; D005934:Glucagon; D006442:Glycated Hemoglobin; D007328:Insulin
vernacular_title: Die Glukosetoleranz im Alter--Anderungen der Insulin-, C-Peptid- und Glukagonsekretion.