Central injection of 5-hydroxytryptamine reduces food intake in obese and lean mice.
The effects of intracerebroventricular (ICV) administration of 5-hydroxytryptamine creatinine sulphate complex (5-HT), 35-140 nmol, on food intake in genetically obese (ob/ob) and lean mice were investigated. 5-HT (70-140 nmol) decreased feeding in a dose-related manner on 1 h and 2 h postinjection measures. Intake in lean mice was reduced by over 70% of the control condition. Obese mice, however, demonstrated a reduced sensitivity to the anorectic effect of 5-HT, and reduced 1 h intake by only 40% of saline control. Although these results are consisted with a role for serotonin in the control of food intake in mice, the altered sensitivity of the ob/ob to serotonergic stimulation may result, in part, from an impaired satiety control mechanism in this mutant.
Currie
P J
PJ
Section of Biopsychology, Clarke Institute of Psychiatry, Toronto, ON, Canada.
Wilson
L M
LM
D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D012528:Satiety Response / Q000187:drug effects; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology*
D012701:Serotonin