title: [Intracranial hemorrhage in hemophiliacs. Study of 10 episodes].
abstract: The intracranial haemorrhages presented within a group of 64 haemophiliacs along 25 years were revised. During this period, 10 such episodes were seen in 8 patients with haemophilia A; six of them appeared in children under 10 years of age. In five instances there were traumatic antecedents, whereas in the remaining five the haemorrhage was spontaneous, no vascular abnormalities being demonstrated in these last. The lesions observed were: intracerebral haematoma in three instances, subdural haematoma in four, subarachnoid haemorrhage in two cases and cerebellar haematoma in one case. Only one of the episodes was lethal, death being related with infectious complications. Recurrences were observed in two patients. Two patients had sequelae with seizures, plus mental retardation and motor deficit in one of them. Substitutive therapy shows capable of controlling this severe complication of haemophilia, provided it is started promptly and fair rates of factor VIII are maintained. Such therapy must be kept for longer periods in these patients with traumatic antecedents.
authors.affiliation: Institución Cátedra y Departamento de Hemoterapia, Hospital de Clínicas Dr. Manuel Quintela, Facultad de Medicina, Montevideo, Uruguay.
authors.forename: N
authors.initials: N
authors.lastname: Bentancor
authors.forename: E
authors.initials: E
authors.lastname: Lavalle
authors.forename: V M
authors.initials: VM
authors.lastname: Vila
authors.forename: E
authors.initials: E
authors.lastname: Johnston
authors.forename: B
authors.initials: B
authors.lastname: Borovich
mesh_terms: D000293:Adolescent; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D006259:Craniocerebral Trauma / Q000150:complications; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D014057:Tomography, X-Ray Computed
vernacular_title: Hemorragias intracraneales en hemofílicos. Estudio de diez episodios.