Acute lymphoblastic leukaemia--a study of immunophenotypes.
Immunological characteristics of leukaemic blast cells from 55 patients of acute lymphoblastic leukaemia were analysed using a panel of monoclonal antibodies and immunoperoxidase technique. Among 36 children the percentage of Common-ALL was found to be low (39%) as compared to western reports, whereas that of T-ALL was high (36%). Out of 19 adults, 52.6% were Common-ALL, 21.1% Early-B-ALL and 16% T-ALL; the findings being consistent with western studies. The T-ALL cases (13) were subclassified according to the stage of thymic maturation depending upon the expression of CD8 and CD4 antigens. Six were identified as early, 3 as common and 4 as late thymocyte stage.
Naeem
S
S
Department of Pathology, King Edward Medical College, Lahore.
Hayee
A
A
D000328:Adult; D000911:Antibodies, Monoclonal; D002648:Child; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology; D008297:Male; D010154:Pakistan; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*; D011379:Prognosis
D000911:Antibodies, Monoclonal