Fibrinous reaction on implanted intraocular lenses. A comparison of conventional PMMA and heparin surface modified lenses.
We studied the fibrinous reaction after intraocular lens (IOL) implantation in the posterior chamber of cynomolgus monkeys. In 50% of the eyes, we implanted an IOL made of conventional poly-(methyl methacrylate) (PMMA); in the remaining eyes we implanted a PMMA IOL with a heparin modified surface. Two, 4, 8, and 18 weeks after surgery the eyes were examined by slitlamp for fibrinous reactions on and around the IOL surface. At weeks 4, 8, and 18 there was a marked decrease in fibrinous reaction in the eyes with a heparin surface modified IOL. The results of this study accord with earlier findings that heparin surface modification improves the biocompatibility of the IOL.
Lundgren
B
B
Kabi Pharmacia Ophthalmics, Department of Biology, Uppsala, Sweden.
Selén
G
G
Spångberg
M
M
Härfstrand
A
A
D000818:Animals; D002387:Cataract Extraction; D005260:Female; D005337:Fibrin / Q000096:biosynthesis*; D005549:Foreign-Body Reaction / Q000378:metabolism; D006493:Heparin; D007910:Lenses, Intraocular; D008252:Macaca fascicularis; D008297:Male; D008768:Methylmethacrylates; D013499:Surface Properties
D008768:Methylmethacrylates; D005337:Fibrin; D006493:Heparin