Elastase-type enzymes and their relation to blood lipids in atherosclerotic patients.
Serum elastase-type activity, elastase inhibitory capacity and their relation to lipids were examined in 140 male patients with ischemic vascular disease (coronary, cerebral, peripheral) and in 60 control subjects. In a further 24 patients with acute myocardial infarction elastase activity, inhibitory capacity and lipids during the course of the illness have also been investigated. Serum elastase-type activity was found to be significantly lower and inhibitory capacity significantly higher in the groups of patients than in the controls. HDL- and HDL2-cholesterol as well as apo A concentration showed significant negative correlation with elastase inhibitory capacity both in atherosclerotic and in control subjects. During the course of myocardial infarction a significant elevation of serum elastase-type activity could be observed at the end of the first week; serum triglyceride levels increased, HDL- and HDL2-concentrations decreased significantly in the first 3 weeks, than gradually approached the initial values. In the patients with an elevation of serum elastase-like activity by more than 30% in the first week, there was a significantly higher elevation of serum GOT and LDH1 and a greater occurrence of transmural (Q) infarction than in those with a smaller variation of elastase-like activity.
Landi
A
A
1st Department of Medicine, Istvan Hospital, Budapest, Hungary.
Bihari-Varga
M
M
Keller
L
L
Mezey
Z
Z
Gruber
E
E
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood* / Q000201:enzymology; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000201:enzymology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000201:enzymology; D010196:Pancreatic Elastase / Q000097:blood*; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000201:enzymology
D008055:Lipids; D010196:Pancreatic Elastase