title: Juvenile rheumatoid arthritis and HLA: report of the Park City III workshop.
abstract: The workshop held during the Park City Meeting was directed toward developing a consensus about HLA associations in juvenile rheumatoid arthritis (JRA). Most agreement was achieved in pauciarticular JRA where the strongest associations were with the HLA-DRB1 alleles as is also the case in IgM rheumatoid factor positive polyarticular disease. In addition, HLA-DP associations are being identified although roles for linked genes are still possible. The critical nucleotides among HLA genes are not known; however, disease specific mutations have not been shown.
authors.affiliation: Virginia Mason Research Center, Department of Pediatrics, University of Washington School of Medicine, Seattle.
authors.forename: B S
authors.initials: BS
authors.lastname: Nepom
authors.forename: D N
authors.initials: DN
authors.lastname: Glass
mesh_terms: D000483:Alleles; D001171:Arthritis, Juvenile / Q000276:immunology* / Q000503:physiopathology; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007596:Joints / Q000503:physiopathology; D012217:Rheumatoid Factor / Q000032:analysis
chemical_list: D006680:HLA Antigens; D007075:Immunoglobulin M; D012217:Rheumatoid Factor