The effects of nimodipine on cocaine toxicity.
The response to nimodipine as an inhibitor of cocaine toxicity was investigated in pentobarbital-anesthetized dogs and in isolated dog heart preparations at constant heart rates. Nimodipine (10 micrograms/kg) markedly decreased peripheral and coronary vascular resistance and increased cardiac output, cardiac work, and coronary blood flow. When corrected for the change in afterload, nimodipine had a positive inotropic response, as measured by +/- maximal dP/dt, in the cocaine-depressed animal. Thus, cocaine toxicity was partially reversed by nimodipine. In the isolated heart preparation, nimodipine resulted in further cardiac depression similar to that seen with other calcium channel antagonists.
Abel
F L
FL
Department of Physiology, University of South Carolina School of Medicine, Columbia 29208.
Wilson
S P
SP
D000704:Analysis of Variance; D000818:Animals; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000633:toxicity; D003331:Coronary Vessels / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009553:Nimodipine / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects
D009553:Nimodipine; D003042:Cocaine