title: Successful treatment of recurrent hepatic Candida infection with fluconazole after chemotherapy for acute leukemia: a case report.
abstract: Hepatic candidiasis represents an increasingly difficult problem in immunocompromised patients. It has been recognized as a variant of disseminated candidiasis after a period of neutropenia. Establishment of diagnosis is difficult since liver biopsy as well as culture may be negative, in spite of the presence of fungus. Hepatic lesions are generally not detectable by ultrasound examination or computed tomography until the neutrophil count has returned to normal. The aim of this case report is to describe the problems related to the diagnosis and treatment of hepatic candidiasis following chemotherapy for acute leukemia. The report also provides further evidence that fluconazole, a new broad-spectrum antifungal drug, can be safely and effectively used for the long-term treatment of deep-seated hepatic candidiasis.
authors.affiliation: Universitätsklinik für Innere Medizin, Universität Innsbruck.
authors.forename: T
authors.initials: T
authors.lastname: Propst
authors.forename: W
authors.initials: W
authors.lastname: Vogel
authors.forename: A
authors.initials: A
authors.lastname: Propst
authors.forename: O
authors.initials: O
authors.lastname: Dietze
authors.forename: H
authors.initials: H
authors.lastname: Braunsteiner
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D002177:Candidiasis / Q000188:drug therapy* / Q000473:pathology; D015725:Fluconazole / Q000627:therapeutic use*; D016469:Fungemia / Q000188:drug therapy; D006505:Hepatitis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology
chemical_list: D015725:Fluconazole