Influence of the stage of pregnancy on gentamicin disposition in the ewe.
The influence of the state of pregnancy (mid- and end of pregnancy) on the kinetic disposition of gentamicin was determined in the ewe. Kinetic parameters were determined after a single intravenous bolus administration (4 mg/kg). It was shown that the steady state volume of distribution was significantly increased from mid to end of pregnancy (from 0.09 I.kg-1 to 0.194 I.kg-1). Similarly, plasma clearance was increased by about 150% at the end of pregnancy. These modifications must be taken into account in order to adapt the dosage regimen and determine a withdrawal time for gentamicin.
Oukessou
M
M
Département de Physiologie et Thérapeutique, Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco.
Toutain
P L
PL
D000818:Animals; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*; D012756:Sheep / Q000378:metabolism*; D014018:Tissue Distribution
D005839:Gentamicins