Microbial production of a crisnatol metabolite.
Microbial metabolism studies of crisnatol (1), a new DNA intercalator, has resulted in the isolation and characterization of a major metabolite identified as the C-1 hydroxylated crisnatol (2). The structure of the metabolite was established by comparison of its spectral data to that of crisnatol. Complete 13C-NMR assignments for crisnatol and its C-1 hydroxylated metabolite were also made.
Hufford
C D
CD
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
el-Sharkawy
S H
SH
Jurgens
T M
TM
Mikell
J R
JR
D000970:Antineoplastic Agents / Q000378:metabolism; D002855:Chromatography, Thin Layer; D002911:Chrysenes / Q000378:metabolism*; D005285:Fermentation / Q000502:physiology; D015394:Molecular Structure; D009090:Mucorales / Q000378:metabolism*; D011409:Propylene Glycols / Q000378:metabolism*
D000970:Antineoplastic Agents; D002911:Chrysenes; D011409:Propylene Glycols; C056722:crisnatol