Keratinocyte expression of class II MHC antigens in long-lasting allergic patch test reactions.
The keratinocyte expression of class II MHC antigens HLA-DR, DP and DQ was studied in 20 long-lasting allergic patch test reactions and 17 normal allergic patch tests reactions. No significant difference in the expression of these antigens in the 2 groups was detected. No 1 allergen was responsible for the majority of long-lasting allergic patch test reactions. The immunological mechanisms which may contribute to long-lasting allergic patch test reactions are discussed with reference to HLA-DR keratinocytes.
Todd
D J
DJ
Department of Dermatology, Royal Victoria Hospital, Belfast, UK.
Handley
J
J
Walsh
M
M
Dolan
O
O
Burrows
D
D
D000328:Adult; D000368:Aged; D005260:Female; D005802:Genes, MHC Class II; D006682:HLA-DP Antigens / Q000096:biosynthesis*; D006683:HLA-DQ Antigens / Q000096:biosynthesis*; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D013997:Time Factors
D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens