Mechanisms of the behavioral effects of interleukin 1. Role of prostaglandins and CRF.
Sickness behavior induced by IL-1 can be assessed quantitatively by measuring disruption of schedule-controlled behavior and loss of interest in social activities displayed by rats or mice injected peripherally or centrally with this monokine. These effects are mediated via the release of prostaglandins since they are blocked by the prostaglandin synthesis inhibitors indomethacin and piroxicam. They do not depend, however, on the central release of CRF, since they are not altered by central administration of either CRF or the specific antagonist of CRF receptors.
Bluthé
R M
RM
INRA-INSERM U 176, Bordeaux, France.
Crestani
F
F
Kelley
K W
KW
Dantzer
R
R
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology*; D051379:Mice; D010894:Piroxicam / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011994:Recombinant Proteins; D012919:Social Behavior
D007375:Interleukin-1; D011453:Prostaglandins; D011994:Recombinant Proteins; D010894:Piroxicam; D003346:Corticotropin-Releasing Hormone; D007213:Indomethacin