Short report: the effect of ranitidine on the post-prandial absorption of a low dose of alcohol.
Twenty healthy male subjects were studied twice using a double-blind, randomized placebo controlled, cross-over study design. Alcohol absorption (integrated 2-h plasma alcohol concentration, peak plasma alcohol concentration, and time to reach peak concentration) was measured after 8 daily doses of either placebo or 300 mg ranitidine. They were given alcohol, 0.15 g/kg of body weight by month after an evening meal. Compared with placebo, there was a trend towards higher integrated 2-h plasma alcohol concentrations (3.17 and 3.89 mg. h/dL, respectively, P = 0.07), and a statistically significant increase in mean peak plasma alcohol concentration after dosing with ranitidine (4.92 and 6.47 mg/dL, respectively, P = 0.05).
Fraser
A G
AG
University Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Hudson
M
M
Sawyerr
A M
AM
Rosalki
S B
SB
Pounder
R E
RE
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D000431:Ethanol / Q000493:pharmacokinetics*; D005502:Food; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D011899:Ranitidine / Q000494:pharmacology*; D013997:Time Factors
D000431:Ethanol; D011899:Ranitidine