Synthesis of a new organic pyrophosphate in large quantities is induced in some bacteria by oxidative stress.
Brevibacterium ammoniagenes and Micrococcus luteus were shown to synthesize up to 50 mM of a novel substance, 2-methylbutan-1,2,3,4-tetraol 2,4-cyclopyrophosphate, in response to oxidative stress created by benzyl viologen and other redox mediators under aerobic conditions. The substance, which represents greater than 50% of the extractable phosphorus, is suggested to play a role as a bacterial antistressor and is thought to be a product of condensation of two molecules of phosphoenolpyruvate whose accumulation is prompted by conversion of intracellular NADPH into an oxidized form.
Ostrovsky
D
D
Bakh Institute of Biochemistry, Moscow, Russia.
Kharatian
E
E
Malarova
I
I
Shipanova
I
I
Sibeldina
L
L
Shashkov
A
A
Tantsirev
G
G
D001951:Brevibacterium / Q000378:metabolism*; D004896:Erythritol / Q000031:analogs & derivatives*; D016982:Micrococcus luteus / Q000378:metabolism*; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000378:metabolism*; D010084:Oxidation-Reduction
D009943:Organophosphorus Compounds; C073443:2-methyl-butan-1,2,3,4-tetraol-2,4-cyclopyrophosphate; D004896:Erythritol