title: Ectopic cartilage in subglottic stenosis: hamartoma or reaction to trauma?
abstract: In an experimental study in growing rabbits an endolaryngeal injury to the subglottis resulted in the development of a stenosis due to the formation of scar tissue containing ectopic cartilage. For comparison, biopsies taken from the subglottic stenosis in 8 children were studied histologically. In 6 cases ectopic cartilage was observed; all patients had a history of endotracheal intubation. In 3 children the diagnosis hamartoma was made. In the remaining 3 cases the formation of ectopic cartilage might have been a direct reaction to the endolaryngeal intubation. The observations suggest that the formation of ectopic cartilage in acquired subglottic stenosis is not always due to a developmental aberration such as a hamartoma.
authors.affiliation: Department of Otorhinolaryngology, Erasmus University Rotterdam, The Netherlands.
authors.forename: F C
authors.initials: FC
authors.lastname: Adriaansen
authors.forename: L J
authors.initials: LJ
authors.lastname: Hoeve
authors.forename: H L
authors.initials: HL
authors.lastname: Verwoerd-Verhoef
authors.forename: R O
authors.initials: RO
authors.lastname: van der Heul
authors.forename: C D
authors.initials: CD
authors.lastname: Verwoerd
mesh_terms: D000818:Animals; D002648:Child; D006222:Hamartoma / Q000473:pathology; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007817:Laryngeal Cartilages / Q000293:injuries* / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000473:pathology; D007829:Laryngostenosis / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D011817:Rabbits