title: Effectiveness of preload reserve as a determinant of clinical status in patients with left ventricular systolic dysfunction. The SOLVD Investigators.
abstract: The hemodynamic determinants of clinical status in patients with left ventricular (LV) systolic dysfunction have not been established. In the present study, preload reserve--LV distension during exercise--was related to clinical status, and the effect of acute angiotensin-converting enzyme inhibition was examined in 97 patients with ejection fraction less than or equal to 0.35 enrolled in the trial, Studies of Left Ventricular Dysfunction (SOLVD). Sixty-one asymptomatic patients (group I) were compared with 36 patients with symptomatic heart failure (group II). Radionuclide LV volumes were measured at rest and during maximal cycle exercise. Group II patients had higher resting heart rates, end-diastolic and end-systolic volumes, and lower ejection fractions (all p less than 0.005). During exercise, only patients in group I had increased stroke volume (from 35 +/- 8 to 39 +/- 11 ml/m2 [mean +/- SD; p less than 0.0005]) due to an increase in end-diastolic volume (from 119 +/- 29 to 126 +/- 29 ml/m2 [p less than 0.0005]), contributing to a greater increase in LV minute output (p less than 0.0001, group I vs group II). After administration of intravenous enalapril (1.25 mg), LV end-diastolic volume response to exercise was augmented in group II (rest, 140 +/- 42; exercise, 148 +/- 43 ml/m2; p less than 0.0005) and LV output response increased slightly (p less than 0.05). Thus, in patients with asymptomatic systolic dysfunction, recruitment of preload during exercise is responsible for maintaining a stroke volume contribution to the cardiac output response.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Tufts University, Boston, Massachusetts.
authors.forename: M A
authors.initials: MA
authors.lastname: Konstam
authors.forename: M W
authors.initials: MW
authors.lastname: Kronenberg
authors.forename: J E
authors.initials: JE
authors.lastname: Udelson
authors.forename: D
authors.initials: D
authors.lastname: Kinan
authors.forename: J
authors.initials: J
authors.lastname: Metherall
authors.forename: N
authors.initials: N
authors.lastname: Dolan
authors.forename: T
authors.initials: T
authors.lastname: Edens
authors.forename: D
authors.initials: D
authors.lastname: Howe
authors.forename: L
authors.initials: L
authors.lastname: Kilcoyne
authors.forename: C
authors.initials: C
authors.lastname: Benedict
mesh_terms: D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002303:Cardiac Output, Low / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D002306:Cardiac Volume / Q000187:drug effects / Q000502:physiology; D004656:Enalapril / Q000627:therapeutic use*; D005080:Exercise Test; D005260:Female; D015637:Gated Blood-Pool Imaging; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009638:Norepinephrine / Q000097:blood; D010919:Placebos; D015635:Radionuclide Ventriculography; D012083:Renin / Q000097:blood; D013318:Stroke Volume / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
chemical_list: D010919:Placebos; D004656:Enalapril; D012083:Renin; D009638:Norepinephrine