Dysplastic nevi, cutaneous melanoma, and gynecologic disorders.
We compared the frequency of reproductive system diseases and disorders among 206 female patients with dysplastic nevi (DN), and/or melanoma, in comparison with random samples of women of comparable age without melanoma. The highest odds ratio (OR) for these age-related diseases and reproductive disorders occurs among the youngest age group of the patients with DN alone (mean age 35.1 +/- 1.2 yr): 44.2% of the DN subjects had one or more reproductive disorders compared with 19.8% of the random sample (OR 3.2, 95% CL (1.6, 6.5), P less than 0.001). The patients with melanoma and DN (mean age 41.5 +/- 1.4 yr) also had a significantly greater percentage of subjects with one or more reproductive disorders, though less so than the DN subjects: 49.4% compared to 33.7% (OR 1.9, 95% CL (1.1, 3.3), P = 0.02).
Frisch
R E
RE
Harvard Center for Population Studies, Cambridge, Massachusetts.
Wyshak
G
G
Albert
L S
LS
Sober
A J
AJ
D000022:Abortion, Spontaneous / Q000150:complications; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001940:Breast / Q000473:pathology; D004416:Dysplastic Nevus Syndrome / Q000150:complications* / Q000235:genetics; D004715:Endometriosis / Q000150:complications; D004717:Endometrium / Q000473:pathology; D005260:Female; D005831:Genital Diseases, Female / Q000150:complications*; D006200:Hair Color; D006801:Humans; D007044:Hysterectomy; D008545:Melanoma / Q000150:complications*; D008875:Middle Aged; D011247:Pregnancy; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics