title: The effects of intraocular gases on rabbit blood-retinal barrier permeability.
abstract: The effects of intravitreal expansile gases, sulfur hexafluoride and octafluoropropane, as well as air and needle insertion alone were assessed by iris fluorescein angiography and blood-retinal barrier permeability determination. Iris angiography, at 3 days after injection, indicated no differences between experimental and paired control eyes. Vitreous fluorophotometry on day 1, day 4 and day 7 after gas or sham injection also showed no differences between paired control and experimental eyes regardless of which experimental condition was employed. The results indicate that these gases are non-toxic to the blood-retinal barrier over a 7 day time course.
authors.affiliation: Department of Ophthalmology, Medical College of Georgia, Augusta 30912.
authors.forename: K
authors.initials: K
authors.lastname: Green
authors.forename: T
authors.initials: T
authors.lastname: Slagle
authors.forename: L
authors.initials: L
authors.lastname: Cheeks
authors.forename: B C
authors.initials: BC
authors.lastname: Norman
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001813:Blood-Retinal Barrier / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects*; D019793:Fluorescein; D005451:Fluorescein Angiography; D005452:Fluoresceins / Q000008:administration & dosage; D005466:Fluorocarbons / Q000494:pharmacology*; D015590:Fluorophotometry; D007498:Iris / Q000098:blood supply; D011817:Rabbits; D013459:Sulfur Hexafluoride / Q000494:pharmacology*; D014822:Vitreous Body / Q000378:metabolism
chemical_list: D005452:Fluoresceins; D005466:Fluorocarbons; C042852:perflutren; D019793:Fluorescein; D013459:Sulfur Hexafluoride