Vaccine protection of chimpanzees against challenge with HIV-1-infected peripheral blood mononuclear cells.
Because human immunodeficiency virus (HIV) can be transmitted as cell-free virus or as infected cells (cell-associated virus), vaccines must protect against infection by both viral forms. Vaccine-mediated protection of nonhuman primates against low doses of cell-free HIV-1, HIV-2, or simian immunodeficiency virus (SIV) has been demonstrated. It is now shown that multiple immunizations of chimpanzees with HIV-1 antigens protected against infection with cell-associated virus. Protection can persist for extended periods (one animal had not been exposed to viral antigens for 1 year before challenge). These results show that it is possible to elicit long-lasting protective immunity against cell-associated HIV-1.
Fultz
P N
PN
Department of Microbiology, University of Alabama, Birmingham 35294.
Nara
P
P
Barre-Sinoussi
F
F
Chaput
A
A
Greenberg
M L
ML
Muchmore
E
E
Kieny
M P
MP
Girard
M
M
D016915:AIDS Vaccines; D000818:Animals; D015488:HIV Antigens / Q000276:immunology / Q000627:therapeutic use; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology*; D007110:Immunity, Active; D007116:Immunization, Passive; D007156:Immunologic Memory; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008137:Longitudinal Studies; D002679:Pan troglodytes / Q000276:immunology*
D016915:AIDS Vaccines; D015488:HIV Antigens