title: Effects of mycobactin J and lactoferrin supplementation of drinking water on the in vivo multiplication of Mycobacterium paratuberculosis in gnotobiotic mice.
abstract: In this study the effect of supplementation of drinking water with mycobactin J or lactoferrin on the multiplication of Mycobacterium paratuberculosis in gnotobiotic mice was investigated. The results indicated that neither mycobactin J nor lactoferrin, at the doses used, appeared to have any effect on fecal shedding or tissue burdens of M. paratuberculosis.
authors.affiliation: Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
authors.forename: H L
authors.initials: HL
authors.lastname: Hamilton
authors.forename: C J
authors.initials: CJ
authors.lastname: Czuprynski
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002432:Cecum / Q000382:microbiology; D003106:Colon / Q000382:microbiology; D004326:Drinking; D005856:Germ-Free Life; D007082:Ileum / Q000382:microbiology; D007121:Immunocompetence; D007413:Intestinal Mucosa / Q000382:microbiology; D007502:Iron Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007781:Lactoferrin / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016927:Mycobacterium avium subsp. paratuberculosis / Q000187:drug effects / Q000254:growth & development*; D010080:Oxazoles / Q000008:administration & dosage / Q000494:pharmacology*; D010283:Paratuberculosis / Q000382:microbiology*
chemical_list: D007502:Iron Chelating Agents; D010080:Oxazoles; C018608:mycobactins; D007781:Lactoferrin