Techniques used to freeze-dry "small doses" of thrombin.
In can be difficult to maintain the moisture level of small quantities of freeze-dried product contained in vials. We have observed that over a period of time a gradual increase in the residual moisture level in Thrombin vials containing small quantities of the freeze-dried product can sometimes be seen. No change in Thrombin potency has been observed. Investigations into the cause and resolution of this situation resulted in (1) modification of the freeze-drying cycle for vials containing small quantities of Thrombin and (2) incorporation of a special drying cycle for vial stoppers.
Jaffe
D R
DR
Warner-Lambert Company, Morris Plains, NJ 07950.
Samyn
J C
JC
Sheehan
G
G
D004349:Drug Packaging / Q000379:methods; D005612:Freeze Drying / Q000379:methods*; D013917:Thrombin / Q000302:isolation & purification*; D014867:Water / Q000032:analysis
D014867:Water; D013917:Thrombin