[Immunohistochemical study of cytosolic estrogen receptor-bound protein in breast cancer. Correlation with a biochemical study. Apropos of 107 surgical specimens].
One hundred and seven breast cancers were studied by immunohistochemistry with a monoclonal antibody revealing a protein bound to cytosolic estrogen receptors ERD5 on paraffin embedded tissue. Seventy seven per cent of the cancers were positive with a variable intensity. In half of the cases, the estrogen cytosolic receptors were also determined by biochemistry. The results were similar in 74% of cases. Estrogen receptors were detected by immunohistochemistry in 18.5% of the cancers which were negative on biochemistry. As is well known, the presence of estrogen in 18.5% of the cancers which were negative on biochemistry. As is well known, the presence of estrogen receptors is an important prognostic factor in breast cancer. Our results, together with the simplicity of the immunohistochemical method, should encourage pathologists to include this analysis in the study of surgical specimens of breast cancers.
Vildé
F
F
Service Central d'Anatomie et de Cytologie Pathologiques, Hôpital Boucicaut, Paris.
Arkwright
S
S
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D001940:Breast / Q000601:surgery; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D003600:Cytosol / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*
D011960:Receptors, Estrogen; D012738:Sex Hormone-Binding Globulin
Etude immunohistochimique d'une protéine liée aux récepteurs cytosoliques aux oestrogènes dans le cancer du sein. Corrélation avec l'étude biochimique. A propos de cent sept pièces d'exérèse.