Use of fluoroquinolones for prophylaxis of murine Pneumocystis carinii pneumonia.
We compared the prophylactic activities of six fluoroquinolones against Pneumocystis carinii pneumonia in immunosuppressed rats. Pefloxacin was the only agent which was as effective as the reference drug trimethoprim-sulfamethoxazole. Clinical trials with pefloxacin in patients at risk for P. carinii pneumonia appear to be justified.
Brun-Pascaud
M
M
Institut National de la Santé et de la Recherche Médicale U. 13., Hôpital Claude Bernard, Paris, France.
Fay
M
M
Zhong
M
M
Bauchet
J
J
Dux-Guyot
A
A
Pocidalo
J J
JJ
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D007165:Immunosuppression Therapy; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000382:microbiology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
D042462:4-Quinolones; D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination