Humoral antimelanoma immunity: induction by mouse antiidiotypic mAb, MK2-23 and association with survival of patients with advanced melanoma.
This study has shown that a mouse antiidiotypic mAb bearing a mirror image of HMW-MAA can break tolerance to a well-defined self HMW-MAA and can induce humoral anti HMW-MAA immunity in patients with melanoma. Furthermore, the induction of an immune response to a well-defined melanoma-associated antigen has been shown to be associated with a favorable clinical response. If this association reflects a cause-effect relationship between the two parameters, the anti HMW-MAA immunity induced by mouse antiidiotypic mAb MK2-23 may effect immune destruction of melanoma cells and may interfere with the metastatic potential of those cells because of the suggested role of HMW-MAA in this phenomenon.
Mittelman
A
A
Department of Medicine, New York Medical College, Valhalla 10595.
Puccio
C
C
Chun
H
H
Ahmed
T
T
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000917:Antibody Formation; D006801:Humans; D008545:Melanoma / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008970:Molecular Weight; D014407:Tumor Cells, Cultured / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal