[Long-term antihypertensive therapy of diabetic patients with felodipine. Effects of treatment on blood pressure and kidney function parameters].
OBJECTIVE
Detection of possible effects on renal function parameters of long-term antihypertensive treatment administered to patients with diabetes mellitus.


METHODS
Prolongation of an open trial, initially planned for one year, on the effect of felodipine 10 mg/day in diabetics (Fortschr. Med. 109 (1991), 53-56). Continued treatment of 7 hypertensive insulin-dependent diabetics (mean age 58 +/- 3 years, HbA1 8.2 +/- 0.3%) over a period of between 24 and 32 months.


RESULTS
The lowered blood pressure (from 160/94 to 150/82 mmHg; p less than 0.05) persisted. In the first 6 months of treatment, urinary albumin excretion (UAE) remained constant. Thereafter it increased (p less than 0.05 as compared with the figure seen after 6 months' treatment) to a degree that varied from one patient to another; overall, the UAE figures showed a relatively large intra-individual fluctuation during long-term therapy. Metabolic parameters remained uninfluenced by felodipine.


CONCLUSIONS
It cannot be excluded that progression of diabetic renal disease cannot be adequately prevented by long-term treatment with calcium antagonists such as felodipine.
Jungmann
E
E
Abteilung für Endokrinologie, Universitätsklinikums Frankfurt/M.
Schumm-Draeger
P M
PM
Scheuermann
E H
EH
Usadel
K H
KH
D001794:Blood Pressure / Q000187:drug effects*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D015736:Felodipine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007328:Insulin / Q000008:administration & dosage*; D007677:Kidney Function Tests; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
D007328:Insulin; D015736:Felodipine
Antihypertensive Langzeittherapie von Diabetespatienten mit Felodipin. Wirkungen der Behandlung auf Blutdruck und Nierenfunktionsparameter.