title: Retinal pigment epithelium implantation in the rabbit: technique and morphology.
abstract: Dysfunction of the retinal pigment epithelium (RPE) is a major component of many degenerative disorders of the retina. We have developed a modified pars plana technique for subretinal implantation of homologous, cultured, carbon-loaded RPE cells in the rabbit. The natural history and morphologic behavior of the implanted RPE cells for up to 6 weeks after transplantation were observed in successful procedures.
authors.affiliation: Department of Ophthalmology, University of Southern California School of Medicine, Los Angeles.
authors.forename: A A
authors.initials: AA
authors.lastname: el Dirini
authors.forename: H M
authors.initials: HM
authors.lastname: Wang
authors.forename: T E
authors.initials: TE
authors.lastname: Ogden
authors.forename: S J
authors.initials: SJ
authors.lastname: Ryan
mesh_terms: D000818:Animals; D002244:Carbon; D002478:Cells, Cultured; D010857:Pigment Epithelium of Eye / Q000637:transplantation* / Q000648:ultrastructure; D011817:Rabbits; D012160:Retina / Q000601:surgery* / Q000648:ultrastructure; D014184:Transplantation, Homologous / Q000379:methods
chemical_list: D002244:Carbon