title: The effect of atrio-ventricular delay programming in patients with DDDR pacemakers.
abstract: Modern DDDR (dual chamber universal, rate responsive) pacemakers are complex, hugely capable devices incorporating new features that theoretically should enhance haemodynamics and therefore quality of life. Ten patients (mean age 48 years) with chronotropic incompetence and high grade A-V block had activity sensing DDDR devices implanted and underwent a randomized double-blind crossover assessment of rate responsive and different fixed atrio-ventricular delay (AVD) settings during 2 weeks of out-of-hospital activity in DDDR mode. Subjective assessment showed improved 'general wellbeing' and preference for 175 ms rate responsive AVD (P less than 0.01) or 125 ms fixed AVD (P less than 0.05). The longest fixed AVD setting (250 ms) was least acceptable and had increased symptom prevalence (P less than 0.02). Perceived exercise capacity and exercise treadmill tolerance was not significantly different at any setting in DDDR mode but was less in DDD mode. Echocardiographically derived stroke distance was greater at 125 ms AVD than 250 ms at 100 b.min-1 (P less than 0.05) but did not differ at slower heart rates at any AVD. Colour Doppler assessed mitral and tricuspid regurgitation was greatest at 250 ms AVD at all heart rates but did not correlate with increased symptomatology. Stroke distance evaluated from the mitral inflow velocity profile allows improved AVD programming during DDDR pacing. Rate adaptive A-V delay is a useful feature during DDDR pacing.
authors.affiliation: Department of Cardiology, Guy's Hospital, London, U.K.
authors.forename: A N
authors.initials: AN
authors.lastname: Sulke
authors.forename: J B
authors.initials: JB
authors.lastname: Chambers
authors.forename: E
authors.initials: E
authors.lastname: Sowton
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001283:Atrioventricular Node / Q000503:physiopathology; D004452:Echocardiography; D004562:Electrocardiography / Q000295:instrumentation*; D005080:Exercise Test / Q000295:instrumentation; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D008838:Microcomputers; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D009200:Myocardial Contraction / Q000502:physiology; D010138:Pacemaker, Artificial; D011788:Quality of Life; D012984:Software; D013599:Systole / Q000502:physiology*; D013610:Tachycardia / Q000503:physiopathology; D014262:Tricuspid Valve Insufficiency / Q000503:physiopathology