title: Comparison of L-hyoscyamine, glucagon, and placebo for air-contrast upper gastrointestinal series.
abstract: Previous studies have compared the use of anticholinergic drugs and glucagon for upper gastrointestinal (UGI) radiography. Many radiologists prefer glucagon because these comparisons showed it to have a shorter duration of action with fewer side effects. L-Hyoscyamine is the levo-rotatory form of atropine with minor adverse side effects. This study compared the effects of glucagon (N = 48), L-hyoscyamine (N = 43), and placebo (N = 45) on gastric and duodenal distension, mucosal coating, and patient tolerance. L-Hyoscyamine provided gastric and duodenal images equal in quality to glucagon. Except for the more frequent reporting of dry mouth with L-hyoscyamine, side effects were not different among the groups. L-Hyoscyamine is an economical alternative to glucagon for hypotonic gastrointestinal radiography.
authors.affiliation: Division of Gastroenterology, University of South Alabama College of Medicine, Mobile 36617.
authors.forename: G
authors.initials: G
authors.lastname: Moeller
authors.forename: J J
authors.initials: JJ
authors.lastname: Hughes
authors.forename: F A
authors.initials: FA
authors.lastname: Mangano
authors.forename: R
authors.initials: R
authors.lastname: Gelormini
authors.forename: T L
authors.initials: TL
authors.lastname: Tomlinson
authors.forename: J A
authors.initials: JA
authors.lastname: DiPalma
mesh_terms: D001285:Atropine / Q000009:adverse effects / Q000494:pharmacology*; D004064:Digestive System / Q000000981:diagnostic imaging* / Q000187:drug effects; D005260:Female; D005934:Glucagon / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011029:Pneumoradiography
chemical_list: D001285:Atropine; D005934:Glucagon