title: [De novo malignant tumors during drug immunosuppression. The findings following 1245 cadaveric kidney transplants in 1080 patients].
abstract: Thirty new malignant tumours were found in 1080 patients (634 men, 446 women; mean age 37.6 +/- 13.6 years) after a median follow-up period of 5 years following 1245 cadaveric kidney transplantations performed between 1972 and 1990. The mean dialysis period before transplantation had been 4.0 +/- 3.1 years. Regarding the type of tumour, carcinomas were by far the most frequent, while there was only one lymphoma. The annual malignancy incidence for renal transplant patients was 0.5%. This is 3.5 times higher for men and 4.2 times for women than in the normal population. Immunosuppression with azathioprine and/or antithymocytic globulin (n = 395) produced the same malignancy incidence (0.54%) as with cyclosporin (n = 685; 0.60%). On the other hand, malignant tumours occurred much earlier under cyclosporin than under azathioprine/antithymocytic globulin (27 and 68 months, respectively).
authors.affiliation: Abteilung für Allgemeine Chirurgie, Universitätsklinikum Essen.
authors.forename: M K
authors.initials: MK
authors.lastname: Walz
authors.forename: K H
authors.initials: KH
authors.lastname: Albrecht
authors.forename: W
authors.initials: W
authors.lastname: Niebel
authors.forename: F W
authors.initials: FW
authors.lastname: Eigler
mesh_terms: D000367:Age Factors; D002102:Cadaver; D002423:Cause of Death; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D016030:Kidney Transplantation / Q000706:statistics & numerical data; D015993:Life Tables; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D012086:Reoperation / Q000706:statistics & numerical data; D012737:Sex Factors
chemical_list: D007166:Immunosuppressive Agents
vernacular_title: De-novo-Malignome unter medikamentöser Immunsuppression. Befunde nach 1245 Leichennierentransplantationen bei 1080 Patienten.