The rate of ethanol absorption is influenced by corticosterone in long-sleep and short-sleep mice.
Ethanol was administered by intragastric (IG) injection and absorption was measured in long-sleep (LS) and short-sleep (SS) mice under various conditions that alter levels of adrenal steroids. In naive mice, LS mice absorbed ethanol more quickly than SS mice. Ethanol absorption was slower in both lines of mice after adrenalectomy (ADX). Short-term inhibition of corticosterone synthesis had no effect on ethanol absorption in either line of mice. The effect of ADX was most pronounced in SS mice at 24 hr after surgery and at 168 hr after surgery in LS mice. Therefore, the effects of various steroid replacements were examined at these times. At 24 hr after ADX, ethanol absorption was replaced to SHAM-operated values in SS mice receiving corticosterone treatments. Likewise, in LS mice at 168 hr after ADX, corticosterone implants reversed the effects of ADX while dexamethasome was ineffective. These results support a role for corticosterone in regulation of gastric ethanol absorption and suggest that the lack of repeatability for pharmacokinetic measures of ethanol absorption and metabolism in previous human and animal studies may relate to environmental impact on stress responses.
Minnick
S A
SA
Department of Psychology, University of Colorado, Boulder 80309.
Wehner
J M
JM
D000311:Adrenal Glands / Q000503:physiopathology; D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D003345:Corticosterone / Q000502:physiology*; D000431:Ethanol / Q000493:pharmacokinetics*; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D051379:Mice; D008815:Mice, Inbred Strains; D012894:Sleep Stages / Q000187:drug effects* / Q000502:physiology; D013045:Species Specificity
D000431:Ethanol; D003345:Corticosterone