Cytogenetic analysis of a United Kingdom series of non-Hodgkins lymphomas.
We describe cytogenetic analyses of cells derived from 40 non-Hodgkins lymphoma (NHL) node biopsies, 23 of which were from patients who had not been treated before biopsy. We noted that the chromosomes most frequently gained were X (32%), 12 (27%), and 3 (24%). Monosomies were much less common; loss of chromosome 13 (13.5%) was most frequent. Structural abnormalities primarily involved chromosomes 14 (70%), 1 (40.5%), 18 (38%), 6 (35%), and 17 (22%). Low-and high-grade disease showed similar patterns of structural changes; however, a markedly greater number of chromosome gains were associated with low-grade disease. Biopsy samples from patients who had previously been treated showed an increased frequency of structural abnormalities, as well as a significantly larger number of chromosome gains. The importance of these observations, particularly with regard to possible oncogene involvement in lymphoma evolution, is discussed.
Hammond
D W
DW
Department of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, England.
Goepel
J R
JR
Aitken
M
M
Hancock
B W
BW
Potter
A M
AM
Goyns
M H
MH
D000782:Aneuploidy; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002887:Chromosomes, Human, Pair 18; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping; D008198:Lymph Nodes / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*