title: [A series of anesthesia for a child with Lowe's syndrome].
abstract: A series of anesthesia for a child with Lowe's syndrome was reported. The boy underwent general anesthesia for 6 times for ophthalmic and dermatologic surgeries in approximately eight years since the age of only four months when the first anesthesia had been given. From the third to the fifth episodes of anesthesia, marked metabolic acidosis was noted, but at the first and second anesthesia, metabolic acidosis had not been recognized. Such acidosis was corrected each time by 7% NaHCO3 infusion at the early stage of anesthesia, and afterwards uneventful courses were seen. In the last anesthesia, acidosis was not found, though disturbance of renal functions were suspected because of abnormal urinary NAG and beta 2-microglobulin value in blood. Attention should be paid to possible anesthetic hazards in Lowe's syndrome patients such as metabolic acidosis due to the renal-tubular dysfunction, the risk of convulsion, glaucoma, the fragility of the bone structures, and so forth.
authors.affiliation: Department of Anesthesiology, Tottori University Hospital, Yonago.
authors.forename: Y
authors.initials: Y
authors.lastname: Watoh
authors.forename: K
authors.initials: K
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Sato
mesh_terms: D000138:Acidosis / Q000209:etiology; D000768:Anesthesia, General / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D009800:Oculocerebrorenal Syndrome / Q000601:surgery*