[Germinal tumors of the mediastinum. Therapeutic strategy, prognosis, biology].
Mediastinal germ cell tumors have a poor prognosis. Cisplatin containing chemotherapy combined with either primary or post-chemotherapy exeresis of the disease can induce a 50% cure rate. Acute leukemia is often associated with these tumors. In these cases, a clonal evolution from the germ cell tumor has been demonstrated.
Droz
J P
JP
Département de Médecine, Institut Gustave-Roussy, Villejuif.
Ruffié
P
P
D014408:Biomarkers, Tumor; D002945:Cisplatin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004407:Dysgerminoma / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007621:Karyotyping; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D009367:Neoplasm Staging; D011379:Prognosis; D013514:Surgical Procedures, Operative / Q000592:standards; D015996:Survival Rate; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D002945:Cisplatin
Tumeurs germinales du médiastin. Stratégie thérapeutique, pronostic, biologie.