title: Degeneration of motor nerve fibers enhances the expression of calcitonin gene-related peptide in rat sensory neurons.
abstract: Calcitonin gene-related peptide (CGRP) in skeletal muscle is of neural origin. After degeneration of sensory fibers induced by removal of the lumbar dorsal root ganglia (DRG), the CGRP content in the rat soleus muscle was reduced to about 5% of the normal level. In contrast, degeneration of motor fibers induced by sectioning of the lumbar ventral roots markedly increased the CGRP content in the soleus muscle and CGRP levels in the lumbar DRG. It is suggested that the expression of CGRP in sensory neurons is up-regulated by some humoral factor induced by degeneration of motor nerve fibers.
authors.affiliation: National Institute for Physiological Sciences, Okazaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Inaishi
authors.forename: Y
authors.initials: Y
authors.lastname: Kashihara
authors.forename: M
authors.initials: M
authors.lastname: Kuno
mesh_terms: D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide / Q000096:biosynthesis* / Q000235:genetics; D005727:Ganglia, Spinal / Q000293:injuries; D005786:Gene Expression Regulation; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000737:chemistry; D009410:Nerve Degeneration; D009414:Nerve Growth Factors / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009475:Neurons, Afferent / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013126:Spinal Nerve Roots / Q000293:injuries
chemical_list: D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D015740:Calcitonin Gene-Related Peptide