No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families.
Evidence for a pseudoautosomal locus for a schizophrenia susceptibility gene was sought by two forms of analysis of 25 multiply affected families. Firstly, in the sample as a whole there was an excess of same-sex over mixed-sex siblings compared with that expected. Secondly, linkage analysis was performed in six of the families. The genotypes were studied for DXYS14, a highly polymorphic marker in the telomeric pseudoautosomal region. No evidence for positive linkage was found with two-point analysis under eight different genetic models for the mode of transmission. A non-parametric, sibling-pair analysis also failed to detect linkage. Our findings provide no evidence for linkage within the pseudoautosomal region; same-sex concordance must arise from some other mechanism.
Asherson
P
P
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff.
Parfitt
E
E
Sargeant
M
M
Tidmarsh
S
S
Buckland
P
P
Taylor
C
C
Clements
A
A
Gill
M
M
McGuffin
P
P
Owen
M
M
D015139:Blotting, Southern; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012730:Sex Chromosomes
D015342:DNA Probes; D004247:DNA