title: [Prophylactic effect of ulinastatin on cisplatin-induced renal disorders in lung cancer patients].
abstract: In order to determine whether ulinastatin (US) can prevent renal dysfunction due to cisplatin (CDDP) or not, we comparatively studied serum BUN, serum creatinine (Cr), creatinine clearance (Ccr), urine gamma-glutamyl transpeptidase (gamma-GTP) excretion, urine N-acetyl-beta-D-glucosaminidase (NAG) excretion, fractional excretion of Na (FENa) and urine beta 2-microglobulin excretion between one group of 10 patients receiving single treatment with CDDP and another group of 10 patients receiving combination treatment with CDDP+US, in 20 subjects with primary lung cancer. In the US combination treatment group, urine gamma-GTP excretion, urine NAG excretion, and FENa elevation were significantly inhibited. Urine beta 2-microglobulin excretion was inhibited. In summary, US was considered to have a preventive effect against renal toxicity due to CDDP.
authors.affiliation: Department of Internal Medicine, Fujita Health University School of Medicine, Second Hospital, Aichi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Horiguchi
authors.forename: J
authors.initials: J
authors.lastname: Kasahara
authors.forename: K
authors.initials: K
authors.lastname: Ogura
authors.forename: M
authors.initials: M
authors.lastname: Handa
authors.forename: H
authors.initials: H
authors.lastname: Hosoda
authors.forename: A
authors.initials: A
authors.lastname: Shakato
authors.forename: S
authors.initials: S
authors.lastname: Tachikawa
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Suetsugu
authors.forename: H
authors.initials: H
authors.lastname: Umeda
mesh_terms: D000368:Aged; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006023:Glycoproteins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D006023:Glycoproteins; C028665:urinastatin; D002945:Cisplatin