title: On the displacement of single-locus polymorphisms.
abstract: And where, along the evolutionary track, some mutant gene did arise which was advantageous in its heterozygous degree of expression but deleterious homozygously, that gene, though temporarily multiplied as a make-shift arrangement, would usually have become replaced, after a while, by mutant genes of less deviant expression, occupying the same or other loci, which gave an equivalent advantage when they were present homozygously. For such genes would make possible a more uniform, and therefore (when all individuals were averaged) a closer approach to the adaptational optimum.
authors.affiliation: Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg 24061.
authors.forename: B
authors.initials: B
authors.lastname: Wallace
mesh_terms: D000483:Alleles; D006579:Heterozygote; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D012641:Selection, Genetic