[Changes in plasma interleukin-1 and their possible relationship with the changes in glucocorticoid receptor in aged long-distance runner].
For the study of the changes in plasma interleukin-1 (IL-1) and their possible relationship with the changes in glucocorticoid receptor (GR), plasma IL-1 and GR in peripheral blood leukocytes in aged long-distance runner were measured simultaneously. The activity of IL-1 was expressed as its ability to stimulate 3H-TdR incorporation in the thymocytes of C57 mice. GR was determined by whole cell assay with 3H-Dex. The results showed that the activity of plasma IL-1 in aged long-distance runner was 209%, 223% and 145% of the control at 14.7-18.7, 3.8-7.0 and 1.5-2.6 KD fractions. The GR in peripheral blood leukocytes in aged runner was 65% of the control. Possible relationship between the changes in IL-1 and GR in aged long-distance runner and its physiological significance are discussed.
Chen
P J
PJ
Department of Rehabilitation and Sports Medicine, Shanghai Institute of Physical Education.
Wei
J W
JW
Fang
M
M
Xu
R B
RB
D000368:Aged; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007590:Jogging; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011965:Receptors, Glucocorticoid / Q000378:metabolism*
D007375:Interleukin-1; D011965:Receptors, Glucocorticoid