title: Evidence for CD8+ cell increase in long-term PUVA-treated psoriatic patients after PUVA discontinuation.
abstract: Long-term PUVA-treated psoriatic patients given maintenance therapy (UVA doses greater than 1,000 J/cm2) have been demonstrated to undergo lymphopenia and a decrease in the total number of circulating CD3+ and CD4+ T cells. The aim of this study was to assess whether the impairment of T cells is detectable also in psoriatic patients after long-lasting PUVA discontinuation. A group of 34 psoriatic patients (25 males, 9 females; mean age 52.7 +/- 12.82 years), who had previously been treated by PUVA therapy (average cumulative dose 1,898.48 +/- 1,207.12 J/cm2), was studied 1 year or more after discontinuation of PUVA therapy. The patients studied failed to show any impairment in CD3+ and CD4+ cells. Nevertheless, a significant increase (p less than 0.05) in circulating CD8+ cells (both in the percentage and the total number) was detectable in PUVA patients as compared to appropriate controls. The significance and implications of this finding are not known and need further investigations.
authors.affiliation: Department of Human and Hereditary Pathology, Institute of Dermatology, Pavia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Borroni
authors.forename: C
authors.initials: C
authors.lastname: Zaccone
authors.forename: G
authors.initials: G
authors.lastname: Vignati
authors.forename: A
authors.initials: A
authors.lastname: Fietta
authors.forename: C
authors.initials: C
authors.lastname: Merlini
authors.forename: G
authors.initials: G
authors.lastname: Rabbiosi
mesh_terms: D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D016896:Treatment Outcome