["Toxins" and nerve--a discussion on the pathogenesis of acrylamide intoxication, giant axonal neuropathy and Krabbe disease].
A common mechanism appears to play a pathogenetic role in acrylamide intoxication, which is due to an exogenous cause, and in giant axonal neuropathy, an intrinsic disorder. In giant axonal neuropathy, a genetic defect in the processing of an intrinsic acrylamide or acrylamide-like substance may be postulated. On the other hand, the devastating pathology in Krabbe disease (a genetic disorder affecting almost exclusively the nervous system) appears to be due to the effects of psychosine, a toxic lipid produced in the nervous system. These suggest that the "toxicological approach" can be more diverse and of greater use than usually considered.
Igisu
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Department of Environmental Toxicology, University of Occupational and Environmental Health, Kitakyushu, Japan.
D020106:Acrylamide; D000178:Acrylamides / Q000506:poisoning*; D000818:Animals; D001369:Axons / Q000473:pathology; D002415:Cats; D004285:Dogs; D006801:Humans; D007965:Leukodystrophy, Globoid Cell / Q000503:physiopathology*; D051379:Mice; D009474:Neurons / Q000187:drug effects; D011609:Psychosine / Q000633:toxicity; D051381:Rats
D000178:Acrylamides; D020106:Acrylamide; D011609:Psychosine