Inherited predisposition to lung cancer.
This chapter summarizes data from epidemiologic and animal model studies which demonstrate that an inherited predisposition influences the incidence of lung cancer. The authors review the cell biologic events that contribute to neoplastic transformation and the biologic processes that influence tumor progression. They describe how host mechanisms may limit the genesis and progression of tumors and discuss how information about mechanisms of carcinogenesis may be applied to estimating the risk of lung cancer in individuals exposed to environmental carcinogens.
Hasday
J D
JD
Department of Medicine, University of Maryland, Baltimore 21201.
McCrea
K A
KA
D002273:Carcinogens / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004260:DNA Repair; D004198:Disease Susceptibility; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000276:immunology; D009857:Oncogenes / Q000235:genetics; D012907:Smoking / Q000009:adverse effects
D002273:Carcinogens