Primary and secondary amenorrhea associated with spironolactone therapy in chronic liver disease.
Women with severe liver disease often have amenorrhea that resolves as liver disease abates. We describe three patients with mild to moderate chronic liver disease and amenorrhea. In each case amenorrhea resolved when spironolactone therapy was discontinued. We suggest that spironolactone, an androgen inhibitor, may also cause reversible amenorrhea.
Potter
C
C
Department of Pediatrics, University of Minnesota, Minneapolis 55455.
Willis
D
D
Sharp
H L
HL
Scharzenberg
S J
SJ
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced* / Q000209:etiology*; D002779:Cholestasis / Q000150:complications; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D007006:Hypogonadism / Q000150:complications; D008103:Liver Cirrhosis / Q000150:complications; D008107:Liver Diseases / Q000150:complications* / Q000188:drug therapy*; D008209:Lymphedema / Q000150:complications; D013148:Spironolactone / Q000009:adverse effects* / Q000627:therapeutic use; D013577:Syndrome
D013148:Spironolactone