[Efficacy and safety of amrinone in the treatment of heart insufficiency in intensive care].
The authors describe the results obtained treating with amrinone for 48 hours 11 patients with acute heart failure. The patients (4 males and 7 females), age range between 50 and 82 years) received an initial bolus of 0.75 mg/kg followed by and infusion which on average was of 5.82 +/- 1.06 (SD) micrograms/kg/min. Besides a subjective and objective clinical improvement they could observe a quick and remarkable improvement of the main hemodynamic parameters (cardiac index, cardiac output, pulmonary capillary wedge pressure, mean pulmonary pressure). The tolerability of the drug was good, except for a decrease in platelet, already described in literature. In conclusion, the Authors consider amrinone a very interesting drug for its positive inotropic and vasodilating activity and because it does not cause an increase of the myocardial oxygen consumption.
Costa
P
P
Istituto di Anestesiologia, Rianimazione e dell'Emergenza, Università degli Studi di Palermo.
Agrò
C
C
Gulotta
G
G
Papa
G
G
Piazza
F
F
Ronga
F
F
Sparacia
B
B
Sansone
A
A
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000676:Amrinone / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D003422:Critical Care; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D014556:Urine
D000676:Amrinone
Efficacia e tollerabilità dell'amrinone nel trattamento dell'insufficienza cardiaca in terapia intensiva.