title: Anti-IL-5 monoclonal antibody inhibits allergic late phase bronchial eosinophilia in guinea pigs: a therapeutic approach.
abstract: In this study the effect of purified rat anti-mouse IL-5 monoclonal antibody on aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid of guinea pigs was studied. The i.p. injection of anti-IL-5 antibody 4 h after aeroallergen challenge inhibited eosinophil infiltration in a dose-dependent fashion. The resulting ED50 was 10 (3.4-32.8) micrograms/kg. The clinical therapeutic usefulness of anti-IL-5 or anti-IL-5-producing cells in asthma/allergy treatment remains to be an intriguing possibility.
authors.affiliation: Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, NJ 08512.
authors.forename: N
authors.initials: N
authors.lastname: Chand
authors.forename: J E
authors.initials: JE
authors.lastname: Harrison
authors.forename: S
authors.initials: S
authors.lastname: Rooney
authors.forename: J
authors.initials: J
authors.lastname: Pillar
authors.forename: R
authors.initials: R
authors.lastname: Jakubicki
authors.forename: K
authors.initials: K
authors.lastname: Nolan
authors.forename: W
authors.initials: W
authors.lastname: Diamantis
authors.forename: R D
authors.initials: RD
authors.lastname: Sofia
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D004802:Eosinophilia / Q000276:immunology / Q000628:therapy*; D006168:Guinea Pigs; D015848:Interleukin-5 / Q000276:immunology*; D008297:Male
chemical_list: D000911:Antibodies, Monoclonal; D015848:Interleukin-5