title: Effect of dietary n-3 fatty acid deficiency on blood-to-brain transfer of sucrose, alpha-aminoisobutyric acid and phenylalanine in the rat.
abstract: Possible alterations in blood-to-brain unidirectional transport of sucrose (mol. wt., 342), alpha-aminoisobutyric acid (mol. wt., 104), and L-phenylalanine (mol. wt., 165) induced by a diet deficient in n-3 polyunsaturated fatty acids were studied with respect to blood-brain barrier function. Two groups of rats were for to two generations with a semisynthetic diet. One group of rats was fed a peanut oil+rapeseed oil diet which contained both essential fatty acids: linoleic acid (18:2 n-6) and alpha-linolenic acid, (18:3 n-3). Another group was fed a diet of peanut oil, this diet (containing 18:2 n-6) was deficient in alpha-linolenic acid. The experiments were performed at 6 months of age. Unidirectional transfer rate constants (Ki) of sucrose, alpha-aminoisobutyric acid and L-phenylalanine were measured. The diet based on peanut oil (deficient in n-3) caused a greater blood-to-brain transport of sucrose but not of alpha-aminoisobutyric acid or L-phenylalanine. These observations indicate that regardless of the mechanisms involved, alterations in essential fatty acids induced by diet can modulate to some extent the blood-brain transport of hydrophilic molecules without a carrier.
authors.affiliation: Department of Physiology, Istanbul Faculty of Medicine, Turkey.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Ziylan
authors.forename: G C
authors.initials: GC
authors.lastname: Bernard
authors.forename: J M
authors.initials: JM
authors.lastname: Lefauconnier
authors.forename: G A
authors.initials: GA
authors.lastname: Durand
authors.forename: J M
authors.initials: JM
authors.lastname: Bourre
mesh_terms: D000621:Aminoisobutyric Acids / Q000493:pharmacokinetics*; D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D004041:Dietary Fats / Q000008:administration & dosage*; D004730:Endothelium, Vascular / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000172:deficiency* / Q000502:physiology; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000502:physiology*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000502:physiology; D008563:Membrane Lipids / Q000378:metabolism; D000074241:Peanut Oil; D010649:Phenylalanine / Q000493:pharmacokinetics*; D010938:Plant Oils / Q000008:administration & dosage; D000074262:Rapeseed Oil; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000493:pharmacokinetics*
chemical_list: D000621:Aminoisobutyric Acids; D004041:Dietary Fats; D005228:Fatty Acids, Essential; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3; D008041:Linoleic Acids; D008563:Membrane Lipids; D000074241:Peanut Oil; D010938:Plant Oils; D000074262:Rapeseed Oil; C100049:2-aminoisobutyric acid; D010649:Phenylalanine; D013395:Sucrose; D019787:Linoleic Acid