[The effect of inactivity on bone mineralization].
In a group of 88 patients, immobile for various reasons a markedly reduced bone mineralization was found, significantly more in patients with denervation of the muscles. As to laboratory indicators, the author recorded a significantly reduced serum calcium level which correlated positively with the mineralization level; there was an insignificantly elevated alkaline phosphatase activity and calciuria. After comprehensive calcium treatment with small doses of vitamin D, and in patients without signs of osteomalacia also with sodium fluoride raised also significantly the serum calcium level, while there was a decline of the alkaline phosphatase activity and a slight increase of calciuria. The fundamental requirement of therapy is burdening of the bones by graded mobilization of the patients. The following series proved useful: isometric contraction of muscles in a recumbent position--standing up, assisted next to the bed--moving round the bed--active rehabilitation.
Kocián
J
J
Katedra interního lékarství, Institutu pro dalsí vzdĕlávání lékarů a farmaceutů, Praha.
D000368:Aged; D015519:Bone Density; D002113:Calcification, Physiologic / Q000502:physiology; D005260:Female; D006801:Humans; D007103:Immobilization / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
Vliv inaktivity na kostní mineralizaci.