Classification of dynamical diseases by new mathematical tools: application of multi-dimensional phase space analyses to the pulsatile secretion of parathyroid hormone.
The biological importance of dynamic hormonal secretion has been demonstrated. There is good evidence from recent studies that parathyroid hormone (PTH) which plays an important role in bone physiology is secreted in a pulsatile manner. In this study we performed a classification of two 'dynamical diseases' namely osteoporosis and hyperparathyroidism by the visualization of dynamic PTH-secretion in multidimensional phase spaces.
Harms
H M
HM
Abteilung Klinische Endokrinologie, Medizinische Hochschule Hannover, Germany.
Prank
K
K
Brosa
U
U
Schlinke
E
E
Neubauer
O
O
Brabant
G
G
Hesch
R D
RD
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000145:classification*; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D008954:Models, Biological; D010024:Osteoporosis / Q000097:blood / Q000145:classification*; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*; D012016:Reference Values; D012636:Secretory Rate
D010281:Parathyroid Hormone