Superinfection of chronic necrotizing pulmonary aspergillosis by Mycobacterium tuberculosis.
A 63-year-old woman with chronic necrotizing pulmonary aspergillosis complicated by active pulmonary tuberculosis is reported. A small infiltrative shadow appeared, but no definite diagnosis was made. Six years later the shadow was found to have increased in size; chest CT revealed a fungus ball, while a transbronchial lung biopsy revealed aspergillus hyphae. The intrabronchial inoculation of amphotericin B proved ineffective, and a lobectomy was performed. Histopathologic findings showed necrotic granulomas containing aspergillus and some acid-fast bacilli. While the superinfection of healed tuberculous lesions by Mycobacteria or Aspergillus species is well documented, their coexistence is rare.
Kohno
S
S
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Hatano
T
T
Yamada
H
H
Maesaki
S
S
Yasuoka
A
A
Kaku
M
M
Koga
H
H
Hara
K
K
D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000175:diagnosis