Hereditary heparin cofactor II deficiency and coronary artery disease.
We here present a Japanese family with type I hereditary heparin cofactor II (HC II) deficiency. The propositus (a 61-year-old man) suffered from angina pectoris and coronary artery disease was confirmed by coronary angiography. He underwent percutaneous transluminal coronary angioplasty (PTCA) four times in one year. Combined use of heparin, aspirin, and nitrates could not prevent the return of his symptoms and restenosis of segment 6 of the left anterior descending artery. His HC II activity and antigen levels were 49% and 50%, respectively, and his daughter also showed similar low levels. Cerebral infarction had occurred in two family members. Argatroban, a selective potent thrombin inhibitor, was administered after the fourth PTCA for the purpose of preventing reocclusion and achieved a successful outcome. A relationship between HC II deficiency and thrombosis has not yet been established. Our case suggests that standard heparin therapy is not effective in preventing restenosis in such individuals, in whom the process is accelerated by thrombin generation at the site where PTCA produces rupture of the atherosclerotic plaque. Argatroban may be more effective under low HC II conditions because of its potent inhibition of thrombin activity at sites of vascular wall damage.
Matsuo
T
T
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Japan
Kario
K
K
Sakamoto
S
S
Yamada
T
T
Miki
T
T
Hirase
T
T
Kobayashi
H
H
D000787:Angina Pectoris / Q000188:drug therapy / Q000235:genetics; D000792:Angiography; D015906:Angioplasty, Balloon, Coronary; D000991:Antithrombins / Q000627:therapeutic use*; D001120:Arginine / Q000031:analogs & derivatives; D003327:Coronary Disease / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D005260:Female; D015844:Heparin Cofactor II / Q000172:deficiency* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010875:Pipecolic Acids / Q000627:therapeutic use*; D013449:Sulfonamides
D000991:Antithrombins; D010875:Pipecolic Acids; D013449:Sulfonamides; D015844:Heparin Cofactor II; D001120:Arginine; C031942:argatroban