title: [Evaluation of the effectiveness of prostacyclin in the treatment of thrombosis of the central retinal vein using a double-blind method].
abstract: The patients were divided by chance into 2 groups: the first one (15 persons) was given a natrium salt of prostacyclin (Epoprostenol Wellcome or Chinoin) in a dose of 5 mg/kg/min. intravenously by an infusion pump in 5 infusions; the control group (15 persons) received instead of prostacyclin a placebo (0.1 M glycine buffer of pH 10.5). Besides all the patients were given Doxium or Calcium dobesilate, Rutinoscorbin, Vitamin C, and Polopyrin S (Soluble Aspirin). Immediately after the completion of the treatment the authors did not find any essential differences between the examined groups. In prolonged observations however one demonstrated a significantly smaller frequency of the development of neovascularization in the eyes of persons treated by prostacyclin in comparison with the control group.
authors.affiliation: Kliniki Okulistycznej AM w Krakowie.
authors.forename: H
authors.initials: H
authors.lastname: Zygulska-Mach
authors.forename: B
authors.initials: B
authors.lastname: Mirkiewicz-Sieradzka
authors.forename: E
authors.initials: E
authors.lastname: Kostka-Trabka
authors.forename: L L
authors.initials: LL
authors.lastname: Grodzińska
authors.forename: A D
authors.initials: AD
authors.lastname: Dembińska-Kieć
authors.forename: B
authors.initials: B
authors.lastname: Romanowska
authors.forename: K
authors.initials: K
authors.lastname: Bieroń
authors.forename: A
authors.initials: A
authors.lastname: Kedzior
authors.forename: M M
authors.initials: MM
authors.lastname: Basista
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D011464:Epoprostenol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012170:Retinal Vein Occlusion / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D014792:Visual Acuity / Q000187:drug effects / Q000502:physiology
chemical_list: D010919:Placebos; D011464:Epoprostenol
vernacular_title: Ocena skuteczności prostacykliny w leczeniu niedrozności zyły środkowej siatkówki z zastosowaniem metody podwójnie ślepej próby.