title: Isolated left main coronary stenosis and mediastinal irradiation.
abstract: This report draws an association between mediastinal irradiation and isolated left main coronary artery stenosis. The report highlights two patients who developed selective left main coronary artery stenosis post mediastinal treatment. In the animal model, it has been shown that high serum cholesterol levels at the time of, or soon after, irradiation are necessary to initiate arteriosclerotic plaque formation.
authors.affiliation: Department of Medicine, Polyclinic Medical Center, Harrisburg, Pennsylvania 17110.
authors.forename: B R
authors.initials: BR
authors.lastname: Chinnasami
authors.forename: R C
authors.initials: RC
authors.lastname: Schwartz
authors.forename: S B
authors.initials: SB
authors.lastname: Pink
authors.forename: R A
authors.initials: RA
authors.lastname: Skotnicki
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D003331:Coronary Vessels / Q000528:radiation effects*; D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008479:Mediastinal Neoplasms / Q000532:radiotherapy*; D008875:Middle Aged; D011832:Radiation Injuries / Q000601:surgery*; D011867:Radioisotope Teletherapy; D012501:Saphenous Vein / Q000637:transplantation
chemical_list: D003037:Cobalt Radioisotopes