Nuclear receptors and chemical carcinogenesis.
A number of non-genotoxic chemical carcinogens can recognize specific intracellular proteins. These cellular targets include members of the nuclear receptor family of ligand-activated transcription factors. Some non-genotoxic carcinogens appear to mimic the action of hormones and growth factors and perturb signal transduction pathways. Their carcinogenic activity may therefore result from the persistent stimulation of such pathways, promoting the growth of initiated cells.
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Imperial Chemical Industries PLC, Central Toxicology Laboratory, Macclesfield, Cheshire, UK.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D011955:Receptors, Drug / Q000378:metabolism*
D002273:Carcinogens; D011955:Receptors, Drug