title: [The use of intravenous nifedipine for the treatment of severe hypertensive crisis. A clinical case].
abstract: Nifedipine is a calcium channel antagonist. Hypertensive crisis during anaesthesia may be elicited during the induction period or by the surgical manipulating of intrapelvic viscera. We report a case in which nifedipine given intravenously (currently an investigational dosage form) was effective in controlling a severe hypertensive crisis at dose averaging 3.4 mcg/kg/min initially and half as much for maintenance. Arterial pressure was controlled as quickly as with nitroprusside, but with no change in heart rate or cardiac output and without other untoward effects during anaesthesia.
authors.affiliation: Unità Operativa di Anestesia e Rianimazione, USL n. 21 del Casentino-Ospedale di Bibbiena Arezzo.
authors.forename: M
authors.initials: M
authors.lastname: Maione
authors.forename: P
authors.initials: P
authors.lastname: Grassi
authors.forename: G P
authors.initials: GP
authors.lastname: Fabbrini
authors.forename: C
authors.initials: C
authors.lastname: Mazzi
authors.forename: P
authors.initials: P
authors.lastname: Nannicini
mesh_terms: D000758:Anesthesia; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D009543:Nifedipine / Q000627:therapeutic use*; D012720:Severity of Illness Index
chemical_list: D009543:Nifedipine
vernacular_title: Uso della nifedipina per via endovenosa per il trattamento di una grave crisi ipertensiva. Caso clinico.