Familial occurrence of multiple nonmelanoma skin cancer.
A survey of patients with histologically confirmed nonmelanoma skin cancer (NMSC) found 12 families in which several members developed skin cancers. The prevalence of NMSC in these families was far greater than in the normal population. The trait appeared to be dominantly inherited, and NMSC developed at an earlier age in succeeding generations, possibly because of a change in sun exposure habits.
Czarnecki
D
D
Repatriation General Hospital, Heidelberg, Victoria, Australia.
Zalcberg
J
J
Meehan
C
C
O'Brien
T
T
Leahy
S
S
Bankier
A
A
Nash
C G
CG
D000293:Adolescent; D000328:Adult; D002280:Basal Cell Carcinoma / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D010375:Pedigree; D012878:Skin Neoplasms / Q000235:genetics*