title: Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles.
abstract: MHC associations with IDDM in a Chinese population were studied to investigate genetic susceptibility to the disorder. The frequency of HLA-DR3 was significantly higher in the diabetic patients (19/49 [38.7%] vs. control subjects, 11/105 [10.5%], Pc less than 1.3 x 10(-3), RR = 5.3 [CI 2.3-12.1]), whereas DR4 was not (11/49 [22.4%] vs. 28/105 [26.7%], NS). The frequency of DR3/4 heterozygosity was higher in the diabetic patients (6/49 [12.2%] vs. control subjects, 0/105 [0%], P = 1.7 x 10(-3), RR = 31.5 [CI 3.8-263.6]). The frequency of DR3/9 heterozygosity also was higher in the diabetic patients (6/49 [12.2%] vs. control subjects, 2/105 [1.9%], P = 0.03, RR = 6.2 [CI 3.0-12.7]). No significant associations were noted between DQB1 alleles and IDDM. Among DR4-positive subjects, the frequency of DQB1 allele DQB1*0302 was higher in the diabetic patients (10/11 [90.0%] vs. control subjects, 12/24 [50%], Pc less than 0.05, RR = 7.0 [CI 1.3-38.0]), and the frequency of DQB1*0401 was significantly lower in the diabetic patients (2/11 [18.2%] vs. control subjects, 16/24 [66.7%], Pc = 0.04, RR = 0.1 [CI 0.02-0.46]). No DR4 subtype was associated significantly with IDDM. The frequency of DQA1*0501, a DQA1 allele, was higher in diabetic patients (22/41 [53.7%] vs. control subjects, 20/95 [21.1%], Pc less than 3 x 10(-3), RR = 4.3 [CI 2.0-9.3]). The frequency of DQA1*0301, which has been associated consistently with IDDM in other ethnic groups, was not significantly higher in the diabetic patients in this study (27/41 [65.9%] vs. control subjects, 53/95 [55.8%], NS).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of Birmingham, United Kingdom.
authors.forename: M A
authors.initials: MA
authors.lastname: Penny
authors.forename: D
authors.initials: D
authors.lastname: Jenkins
authors.forename: C H
authors.initials: CH
authors.lastname: Mijovic
authors.forename: K H
authors.initials: KH
authors.lastname: Jacobs
authors.forename: D A
authors.initials: DA
authors.lastname: Cavan
authors.forename: V T
authors.initials: VT
authors.lastname: Yeung
authors.forename: C S
authors.initials: CS
authors.lastname: Cockram
authors.forename: B R
authors.initials: BR
authors.lastname: Hawkins
authors.forename: J A
authors.initials: JA
authors.lastname: Fletcher
authors.forename: A H
authors.initials: AH
authors.lastname: Barnett
mesh_terms: D000483:Alleles; D001483:Base Sequence; D002681:China; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D004198:Disease Susceptibility; D005787:Gene Frequency; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens