title: [Drug therapy of gallstone disease].
abstract: Cholesterol stones in the gallbladder can be dissolved in 60 to 90% by oral administration of chenodeoxycholic acid, ursodeoxycholic acid or the combination of both. The effect depend on the number and size of stones. Treatment is without any side effects and lethality. A great number and large stones can be dissolved by direct instillation of methyl-tert-butyl-ether (MTBE) into the gallbladder using the percutaneous transhepatic method. The success rate amounts to 90%, the average therapy duration is 9 hours. Solvents for chemolitholysis of pigmented stones are being tested.
authors.affiliation: Abteilung für Gastroenterologie, Johann-Wolfgang-Goethe-Universität Frankfurt.
authors.forename: U
authors.initials: U
authors.lastname: Leuschner
mesh_terms: D002635:Chenodeoxycholic Acid / Q000627:therapeutic use*; D002769:Cholelithiasis / Q000188:drug therapy*; D004987:Ethers / Q000627:therapeutic use; D006801:Humans; D008738:Methyl Ethers; D012997:Solvents / Q000627:therapeutic use; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
chemical_list: D004987:Ethers; D008738:Methyl Ethers; D012997:Solvents; D002635:Chenodeoxycholic Acid; C043243:methyl tert-butyl ether; D014580:Ursodeoxycholic Acid
vernacular_title: Medikamentöse Therapie des Gallensteinleidens.