Microencapsulation of propranolol hydrochloride by the solvent evaporation technique.
Propranolol hydrochloride microcapsules were prepared by the coacervation-phase separation induced by solvent evaporation technique. The cellulose acetate phthalate was employed as coating material alone and in combination with ethyl cellulose. The prepared microcapsules were evaluated for their drug content, particle size distribution (microscopic method), flow properties, bulk density, in vitro dissolution and drug release kinetics.
Manekar
N C
NC
Department of Pharmaceutical Sciences, Nagpur University, India.
Puranik
P K
PK
Joshi
S B
SB
D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D007700:Kinetics; D011433:Propranolol / Q000008:administration & dosage*; D012997:Solvents / Q000737:chemistry; D014835:Volatilization
D012997:Solvents; C013517:ethyl cellulose; D002482:Cellulose; C011708:cellulose acetate phthalate; D011433:Propranolol