Effects of the clotting process on endothelium-dependent relaxation of human middle cerebral artery.
Clotted blood decreased acetylcholine-induced relaxations of strips of human middle cerebral artery precontracted with noradrenaline, although histologically the endothelial layer was preserved. This effect was not prevented by catalase, superoxide dismutase or aspirin. Nifedipine reduced the decrease in acetylcholine-induced relaxation.
Akopov
S E
SE
Department of Pharmacology, Yerevan Medical Institute, Armenia, Russia.
Gabrielian
E S
ES
D000109:Acetylcholine / Q000494:pharmacology; D001777:Blood Coagulation / Q000502:physiology*; D002536:Cerebral Arteries / Q000187:drug effects / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D000109:Acetylcholine