title: Effects of amiodarone on the pharmacokinetics and toxicity of digoxin in laboratory animals.
abstract: Some pharmacokinetic interactions between digoxin and amiodarone were studied in experiments on rabbits. An increase of digoxin serum levels was established in amiodarone-treated rabbits (amiodarone 30 mg/kg s.c. for five days alone or together with digoxin). The calculated elimination half-life (t 1/2) and the area under the curve (AUC) of digoxin were increased and the digoxin clearance was decreased, being most pronounced in animals receiving amiodarone-digoxin combination for five days. There were no changes either in digoxin toxicity in amiodarone-treated guinea pigs or in serum levels of T4, T3 and TTH. The possible mechanisms of digoxin-amiodarone interactions are discussed.
authors.affiliation: Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
authors.forename: D
authors.initials: D
authors.lastname: Staneva-Stoytcheva
authors.forename: E
authors.initials: E
authors.lastname: Kristeva
mesh_terms: D000638:Amiodarone / Q000494:pharmacology*; D000818:Animals; D004077:Digoxin / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D004347:Drug Interactions; D006168:Guinea Pigs; D007457:Iodine Radioisotopes; D008297:Male; D011817:Rabbits; D013974:Thyroxine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D004077:Digoxin; D000638:Amiodarone; D013974:Thyroxine