Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma.
Although ependymomas comprise 5-10% of pediatric brain tumors, consistent cytogenetic aberrations have not been identified in these neoplasms. We report karyotypes for two ependymomas. A predominantly well-differentiated ependymoma contained several numerical chromosome aberrations, including monosomy 22. In contrast, an anaplastic ependymoma had a more complex karyotype that included loss of one chromosome 22 homologue and a balanced translocation at q13.3 in the remaining 22 homologue. These findings suggest the location of an ependymoma tumor suppressor gene on the long arm of chromosome 22.
Weremowicz
S
S
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Kupsky
W J
WJ
Morton
C C
CC
Fletcher
J A
JA
D001932:Brain Neoplasms / Q000235:genetics*; D002551:Cerebral Ventricle Neoplasms / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002892:Chromosomes, Human, Pair 22; D004806:Ependymoma / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D008297:Male; D009006:Monosomy; D014178:Translocation, Genetic / Q000235:genetics*