[Extravascular thermal volume in pulmonary emphysema].
The extravascular thermal volume of the lung (ETVL) was measured by the heat-sodium double indicator dilution technique in 10 patients with chronic pulmonary emphysema. ETVL was 4.99 +/- 1.23 ml/kg, and correlated significantly with TLC(r = 0.747), %VC(r = 0.664), PaO2(r = 0.779), AaDO2(r = -0.796), shunt ratio(r = -0.7), and total pulmonary vascular resistance(r = 0.698). ETVL tended to decrease with the progression of the severity of emphysema as assessed by computed tomography. These results suggest that 1) the extravascular thermal volume decreases in chronic pulmonary emphysema parallel with an increase in the severity of the complaint, and that 2) the decrease of extravascular thermal volume may reflect a decrease in the size of the pulmonary capillary bed. It is concluded that the measurement of extravascular thermal volume may be useful for the evaluation of the severity of pulmonary emphysema.
Kubo
S
S
Department of Internal Medicine, National Nagasaki Hospital.
Shimoda
T
T
Fujita
K
K
Nakatomi
M
M
Hara
K
K
D000368:Aged; D002908:Chronic Disease; D015633:Extravascular Lung Water / Q000378:metabolism; D005260:Female; D006439:Hemodynamics; D006358:Hot Temperature; D006801:Humans; D007201:Indicator Dilution Techniques; D008297:Male; D011651:Pulmonary Artery / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000175:diagnosis*