Granulocytic sarcoma of the uterine cervix--literature review of granulocytic sarcoma of the female genital tract.
Granulocytic sarcoma is an extramedullary tumor of malignant granulocytic progenitor cells that accompanies, heralds, or signals relapse of acute myelogenous leukemia (AML), or indicates blastic transformation of a chronic myeloproliferative disorder. We describe a case involving the uterine cervix of a 51-year-old woman that led to the diagnosis of AML. Granulocytic sarcoma can occur in the female genital tract and may be the first clinically significant manifestation of a hematologic malignancy. The salient findings in 28 reported cases from 12 different countries are reviewed. Awareness of this lesion is important for all medical personnel involved in the health care of women.
Friedman
H D
HD
Department of Pathology, SUNY-Health Science Center, Syracuse 13210.
Adelson
M D
MD
Elder
R C
RC
Lemke
S M
SM
D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000473:pathology*; D008595:Menorrhagia / Q000209:etiology; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000150:complications / Q000473:pathology*