Thyroid follicular cells produce interleukin-8.
Interleukin-8 (IL-8) is a potent proinflammatory cytokine known to be produced by several cell types. To elucidate whether endocrine cells can also make IL-8, we have tested supernatants from eleven thyroid follicular cell primary cultures. IL-8 was readily detected under basal conditions (range 3.4-32.1 ng/ml from 1 x 10(5) cells in 3 days) and was increased 4-20 fold by stimulation with IL-1. TSH and tumor necrosis factor had an inconsistent effect, while gamma-interferon reduced basal and IL-1-stimulated IL-8 production. Since IL-8 can act as a chemoattractant for lymphocytes, these observations may explain in part the accumulation of lymphocytes within the gland in autoimmune thyroiditis.
Weetman
A P
AP
Department of Medicine, University of Sheffield Clinical Sciences Centre, Northern General Hospital, U.K.
Bennett
G L
GL
Wong
W L
WL
D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D016209:Interleukin-8 / Q000096:biosynthesis*; D013961:Thyroid Gland / Q000166:cytology* / Q000378:metabolism*; D013965:Thyroidectomy; D013972:Thyrotropin / Q000494:pharmacology
D016209:Interleukin-8; D007371:Interferon-gamma; D013972:Thyrotropin