Divergent selection for pentobarbital-induced sleeping times in mice.
A pharmacogenetic model for sensitivity of mice to pentobarbital is being developed by selection for sleep-time response. One generation of divergent selection for long and short sleep-time in mice resulted in a 19% increase in the long-sleep line and a 15% decrease in the short-sleep line. Calculated heritability estimates averaged 0.49 and realized heritabilities averaged 0.24. The extent of the selection progress and the heritability values indicate that genetic constitution plays a major role in controlling variations of sleep-time response to pentobarbital.
Stino
F K
FK
Florida A&M University, College of Pharmacy, Tallahassee, Fla. 32307.
D000704:Analysis of Variance; D000818:Animals; D005260:Female; D005796:Genes; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D010641:Phenotype; D012641:Selection, Genetic; D012890:Sleep / Q000187:drug effects*
D010424:Pentobarbital