Endothelin-1 release from the mesenteric arteries of cyclosporine-treated rats.
The release of endothelin-1 from mesenteric arteries from cyclosporine-treated rats was measured by a specific enzyme immunoassay after purification of the perfusate on an immunoaffinity column. Mesenteric arteries from cyclosporine-treated rats (25 mg/kg per day for 6 weeks) released a significantly larger amount of endothelin-1 than arteries from vehicle-treated control rats (P less than 0.05). Serum creatinine levels were not significantly different in the two groups. These findings indicate that cyclosporine is a potential inducer of endothelin release from the mesenteric artery.
Takeda
Y
Y
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.
Miyamori
I
I
Yoneda
T
T
Takeda
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016572:Cyclosporine / Q000009:adverse effects / Q000494:pharmacology*; D016232:Endothelins / Q000378:metabolism*; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D016232:Endothelins; D016572:Cyclosporine