title: Preliminary evaluation of HER-2/neu oncogene and epidermal growth factor receptor expression in normal and neoplastic human ovaries.
abstract: The HER-2/neu oncogene (a member of the Erb-like oncogene family) is distinct from but closely related to the c-erb B gene which encodes the epidermal growth factor receptor (EGFr). HER-2/neu gene amplification was found in a large number of mammary carcinomas and there was a strong correlation between this phenomenon and poor prognosis. In our study HER-2/neu oncogene expression was determined in 16 malignant ovarian tumors, 2 ovarian lymphomas and 5 normal ovaries. The HER-2/neu gene was found both in normal ovaries and malignant tumors, without any apparent difference among the various histological types. In all the specimens examined, HER-2/neu expression did not seem to be related to EGF binding capacity.
authors.affiliation: Regina Elena Institute for Cancer Research, Roma, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Mileo
authors.forename: M
authors.initials: M
authors.lastname: Fanuele
authors.forename: F
authors.initials: F
authors.lastname: Battaglia
authors.forename: G
authors.initials: G
authors.lastname: Scambia
authors.forename: C
authors.initials: C
authors.lastname: Benedetti-Panici
authors.forename: E
authors.initials: E
authors.lastname: Mattei
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
authors.forename: A
authors.initials: A
authors.lastname: Delpino
mesh_terms: D066246:ErbB Receptors / Q000032:analysis* / Q000235:genetics; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D010053:Ovary / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis
chemical_list: D012333:RNA, Messenger; D012334:RNA, Neoplasm; D066246:ErbB Receptors