Fine-needle aspiration biopsy of hepatic angiosarcoma: report of a case with immunocytochemical findings.
Hepatic angiosarcoma (Kupffer cell sarcoma) is a very rare but ominous malignancy. We report a case diagnosed by fine-needle aspiration biopsy (FNAB). The smear showed malignant spindle cells and a few rounded cells. The diagnosis was made on the cell block by the characteristic scaffolding arrangement of malignant cells along preexisting hepatocytes. This is the first report with immunocytochemical findings. The tumour cells stained positively for vimentin and negatively for keratin, factor VIII, Ulex europaeus agglutinin I (UEA-1), carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), and lysozyme. This case demonstrates the possibility of a definitive diagnosis by FNAB prior to death without inflicting serious complications.
Wong
J W
JW
Department of Pathology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
Bedard
Y C
YC
D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D006394:Hemangiosarcoma / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*