Expression of GAD mRNA in GABA interneurons of the rat medial frontal cortex.
The distribution of glutamic acid decarboxylase (GAD) mRNA containing cells was studied in the rat medial frontal cortex (MFC). The neurons labelled by the 35S-labelled cDNA probe were distributed uniformly throughout all the layers and represented 16% of the total neuronal population. It was possible to distinguish two cell populations expressing high and low levels of GAD mRNA corresponding to 63% and 27% of labelled cells, respectively. Concerning the laminar distribution of these two populations of GAD mRNA containing neurons, no marked difference was observed between the various areas of the MFC.
Rétaux
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Laboratoire de Neurochimie-Anatomie, Université Paris 6-Pierre et Marie Curie, France.
Julien
J F
JF
Besson
M J
MJ
Penit-Soria
J
J
D000818:Animals; D002452:Cell Count; D004790:Enzyme Induction; D005625:Frontal Lobe / Q000166:cytology* / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000032:analysis*; D007395:Interneurons / Q000201:enzymology*; D008297:Male; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D012333:RNA, Messenger; D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase