title: [Optic neuritis in non-Hodgkin's lymphoma].
abstract: Optic neuropathy during non-Hodgkin lymphoma is a late central nervous system complication of unfavourable prognosis. It appears especially with involvement of the bone marrow. A normal cerebrospinal fluid, lack of any beneficial effect of the chemo-corticotherapy and absence of papilledema suggest paraneoplastic, or iatrogenic (radio and (or) chemotherapeutic) neuropathy with conclusive histopathological proof only at autopsy. More frequently, cerebrospinal fluid containing malignant cells, papilledema and a beneficial effect of the chemocortico-therapy suggests malignant infiltration of the optic nerve as occurs in our case. Optic neuropathy during non-Hodgkin lymphoma may exceptionally precede the systemic disease by several years. Early oculomotor involvement suggests meningeal malignant infiltration as found in meningeal carcinomatosis.
authors.affiliation: Département d'Ophtalmologie, UIA, Belgique.
authors.forename: A
authors.initials: A
authors.lastname: Neetens
authors.forename: A
authors.initials: A
authors.lastname: Clemens
authors.forename: P
authors.initials: P
authors.lastname: van den Ende
authors.forename: R
authors.initials: R
authors.lastname: De Bock
authors.forename: I
authors.initials: I
authors.lastname: Neetens
mesh_terms: D005074:Evoked Potentials, Visual / Q000502:physiology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000175:diagnosis* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D014792:Visual Acuity / Q000502:physiology
vernacular_title: Nevrite optique dans le lymphome non Hodgkinien.