title: Cardiopulmonary responses to experimentally induced gastric dilatation in isoflurane-anesthetized dogs.
abstract: Gastric dilatation was experimentally induced in 6 anesthetized dogs maintained with constant-dose isoflurane in oxygen. An intragastric balloon was used to distend the stomach with a constant 30 mm of Hg pressure for 3.5 hours. The PaCO2 was maintained between 35 and 45 mm of Hg, using intermittent positive-pressure ventilation. Cardiopulmonary measurements prior to stomach distension (baseline) were compared with measurements taken during 0.1, 0.5, 1.0, 1.5, 2.5, and 3.5 hours of stomach distension by analyzing the change from baseline in a randomized-block analysis with each dog as a block. After distending the stomach, cardiac index increased (P less than 0.01) from 1.5 to 3.5 hours. Stroke volume did not change, thus the increase in the cardiac index was attributable to an increase in heart rate. During inflation, increases were observed in systemic arterial, pulmonary arterial, and right atrial pressure. Respiratory frequency was unchanged; however, to maintain PaCO2 constant, it was necessary to progressively increase peak airway pressure. Although PaO2 tended to decrease during gastric dilation, the dogs were never hypoxemic. These results indicate that when our methods are used to maintain a constant anesthetic dose of isoflurane in oxygen, an observed increase in cardiovascular performance is expected. This differs from other studies in anesthetized dogs that have shown reduction in cardiovascular performance following gastric dilatation.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University, Fort Collins 80523.
authors.forename: D S
authors.initials: DS
authors.lastname: Hodgson
authors.forename: C I
authors.initials: CI
authors.lastname: Dunlop
authors.forename: P L
authors.initials: PL
authors.lastname: Chapman
authors.forename: J L
authors.initials: JL
authors.lastname: Grandy
mesh_terms: D000769:Anesthesia, Inhalation / Q000662:veterinary; D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D003187:Compliance; D004108:Dilatation, Pathologic / Q000503:physiopathology / Q000662:veterinary; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D006339:Heart Rate; D006439:Hemodynamics; D007530:Isoflurane; D010100:Oxygen / Q000097:blood; D012119:Respiration; D013272:Stomach Diseases / Q000503:physiopathology / Q000662:veterinary*; D013318:Stroke Volume
chemical_list: D002245:Carbon Dioxide; D007530:Isoflurane; D010100:Oxygen