title: Study on the metabolism of racemic prolintane and its optically pure enantiomers.
abstract: 1. Asian and European volunteers were given racemic prolintane, and the metabolites in the 24 h urine were identified and quantified by g.l.c. mass spectroscopy using synthetic reference compounds. 2. R-(+)- and S-(-)-prolintane were synthesized from optically active phenylalanine. The metabolism of the enantiomers differs mainly in the quantitative amounts of metabolites.
authors.affiliation: Pharmazeutisches Institut, Universität Bonn, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Rücker
authors.forename: M
authors.initials: M
authors.lastname: Neugebauer
authors.forename: D
authors.initials: D
authors.lastname: Zhong
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D011759:Pyrrolidines / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D044465:White People / Q000235:genetics
chemical_list: D011759:Pyrrolidines; C005598:prolintane