NMR assignments of territrems A, B, and C and the structure of MB2, the major metabolite of territrem B by rat liver microsomal fraction.
The 1H- and 13C-nmr assignments of territrems A, B, and C [1-3] were made by using nOe and 2D nmr techniques. Following the same methods, the structure of MB2 [4], the major product of territrem B incubated with rat liver microsomal fraction, was determined as a hydroxylation product at the pro S methyl group of C-4 of territrem B.
Lee
S S
SS
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Republic of China.
Peng
F C
FC
Chiou
C M
CM
Ling
K H
KH
D000818:Animals; D006900:Hydroxylation; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000378:metabolism*; D011714:Pyrans / Q000032:analysis*; D051381:Rats
D011714:Pyrans; C075495:4-hydroxymethyl-4-demethylterritrem B; C040404:territrem A; C040405:territrem B; C040403:territrem C