Effect of vitamin C supplementations on iron deficiency anemia in Chinese children.
A total of 65 children with mild iron deficiency anemia (IDA) were divided into 5 groups, and received 0, 25, 50, 100 and 150 mg/day of vitamin C (VC) respectively every day for 8 weeks. Hemoglobin, serum ferritin, free erythrocyte and hematocrit were determined every week. At a daily average intake of about 30 mg of VC and 7.5 mg of Fe, the results of the study indicate that: (1) VC supplement alone could effectively control children's IDA, and a dose-dependent relationship was observed. (2) 50 mg/day of VC is the most efficient dosage and 6 weeks is the shortest time for an effective therapy. (3) With a diet predominantly comprised of plant foods, it is suggested that appropriate dose of VC should be supplemented for the children during winter and spring in northeastern areas of China.
Mao
X
X
Department of Nutrition and Environment Hygiene, Institute of Basic Medicine, Shenyang, China.
Yao
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G
D000747:Anemia, Hypochromic / Q000097:blood / Q000188:drug therapy*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D002675:Child, Preschool; D002681:China; D004305:Dose-Response Relationship, Drug; D005260:Female; D005293:Ferritins / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D011524:Protoporphyrins / Q000097:blood; D013997:Time Factors
D006454:Hemoglobins; D011524:Protoporphyrins; D005293:Ferritins; D001205:Ascorbic Acid