1-(5'-Fluoro-6'-hydroxy-5',6'-dihydrouracil-5'-yl)-5-fluorouracil, a novel N(1)-C(5)-linked dimer that releases 5-fluorouracil by radiation activation under hypoxic conditions.
Nishimoto
S
S
Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University, Japan.
Hatta
H
H
Ueshima
H
H
Kagiya
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004563:Electrochemistry; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000528:radiation effects; D051379:Mice; D008809:Mice, Inbred C3H; D011355:Prodrugs / Q000494:pharmacology / Q000528:radiation effects*; D013941:Thymine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D011355:Prodrugs; C075803:1-(5'-fluoro-6'-hydroxy-5',6'-dihydrouracil-5'-yl)-5-fluorouracil; D013941:Thymine; D005472:Fluorouracil