title: Secretion of macrophage cytotoxic factors induced by new desmuramyl acylpseudopeptide analogs of muramyl dipeptide.
abstract: Sixteen desmuramyl analogs of muramyl dipeptide (MDP) were tested for their abilities to stimulate cytotoxic factor secretion by mouse peritoneal macrophages. Among them, the pseudohexapeptide Boc-Gly psi [CH2O]-D-Ala-Ala-D-Glu[Lys(H-Gly)NHEt]-NH2 appeared to be four times more effective than MDP. From this study, the D configuration of the pseudo-alanyl (or lactyl) residue appears to be essential for activity.
authors.affiliation: Département de Biochimie des Glycoconjugués et Lectines Endogènes, CNRS, Orléans, France.
authors.forename: P
authors.initials: P
authors.lastname: Breton
authors.forename: C
authors.initials: C
authors.lastname: Petit
authors.forename: M T
authors.initials: MT
authors.lastname: Bousser
authors.forename: M
authors.initials: M
authors.lastname: Monsigny
authors.forename: R
authors.initials: R
authors.lastname: Mayer
authors.forename: A C
authors.initials: AC
authors.lastname: Roche
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D016215:Macrophage-Activating Factors / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010529:Peritoneal Cavity / Q000166:cytology; D013268:Stimulation, Chemical
chemical_list: D016215:Macrophage-Activating Factors; D000119:Acetylmuramyl-Alanyl-Isoglutamine