Use of protein electrophoresis in the diagnosis of cerebrospinal fluid rhinorrhoea.
The diagnosis of CSF rhinorrhoea on clinical grounds alone can be difficult. We describe how the use of non-invasive electrophoretic analysis of nasal secretions for tau protein (asialotransferrin) helped in the management of cases where the existence of a CSF leak was in doubt. Patients were thus saved unnecessary invasive investigations or surgery. A modification of the method of analysis, which improves diagnostic accuracy, is described.
Porter
M J
MJ
Department of Neuro-otology, National Hospital for Neurology and Neurosurgery, Queen Square, London.
Brookes
G B
GB
Zeman
A Z
AZ
Keir
G
G
D000328:Adult; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002559:Cerebrospinal Fluid Rhinorrhea / Q000175:diagnosis*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D008297:Male; D016875:tau Proteins / Q000032:analysis*
D002556:Cerebrospinal Fluid Proteins; D016875:tau Proteins