title: Understanding the functions of titin and nebulin.
abstract: Individual molecules of the giant muscle proteins titin and nebulin span large distances in the sarcomere. Approximately one-third of the titin molecule forms elastic filaments linking the ends of thick filaments to the Z-line. The remainder of the molecule is probably bound to the thick filament where it may regulate assembly of myosin and the other thick filament proteins. This region also contains a sequence similar to catalytic domains in protein kinases. Nebulin appears to be associated with thin filaments and may regulate actin assembly.
authors.affiliation: Department of Veterinary Medicine, Bristol University, UK.
authors.forename: J
authors.initials: J
authors.lastname: Trinick
mesh_terms: D002352:Carrier Proteins / Q000502:physiology*; D064211:Connectin; D008565:Membrane Proteins / Q000502:physiology*; D009124:Muscle Proteins / Q000502:physiology*; D011494:Protein Kinases
chemical_list: D002352:Carrier Proteins; D064211:Connectin; D008565:Membrane Proteins; D009124:Muscle Proteins; C035620:nebulin; D011494:Protein Kinases