[Development in the metabolism of dopamine and its derivatives. Application to gross development disorders].
Dopamine (DA) and its metabolites homovanillic acid (HVA) in total, free and conjugated forms, dihydroxyphenylacetic acid (DOPAC) in total, free and conjugated forms, and 3 methoxytyramine (3 MT) levels were determined in the urine of autistic children from 2 years 8 months to 12 years of age and compared to those in normal children of identical age. Very significant group and age effects were found for DA, HVA and 3 MT. In the discussion, results are related to the hypothesis of a disorder in the maturation of the dopaminergic systems in infantile autism.
Martineau
J
J
INSERM U316, explorations fonctionnelles psychopathologiques, Centre hospitalier régional universitaire, Tours, France.
Garreau
B
B
Barthélémy
C
C
Jouve
J
J
Lelord
G
G
D015102:3,4-Dihydroxyphenylacetic Acid / Q000652:urine; D000375:Aging / Q000378:metabolism*; D000704:Analysis of Variance; D001321:Autistic Disorder / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000031:analogs & derivatives / Q000652:urine*; D005260:Female; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D008297:Male
D015102:3,4-Dihydroxyphenylacetic Acid; C001746:3-methoxytyramine; D004298:Dopamine; D006719:Homovanillic Acid
Evolution du métabolisme de la dopamine et de ses dérivés au cours du développement. Application aux troubles globaux du développement.