Association between total cholesterol and thromboxane B2 levels in offspring of parents suffering from premature coronary artery disease.
Relationship between plasma thromboxane B2 concentration and serum total cholesterol level was studied in 129 healthy 3 to 18 years old children, 77 girls and 52 boys, without any family history of premature coronary artery disease and in 181 offspring, 105 girls and 76 boys, of parents suffering from acute myocardial infarction before the age of 45. It was identified an enhancement in serum total cholesterol level of endangered children, and an elevated release of thromboxane A2 in affected girls. A significant negative correlation was found between serum total cholesterol concentration and plasma thromboxane B2 level in healthy girls. However, there was no correlation between serum total cholesterol level and plasma thromboxane B2 concentration in the children whose parents had premature coronary artery disease. It appears, from our results, that this in an alteration of thromboxane A2 release of platelets in children of families with high risk of cardiovascular diseases.
Mihai
K
K
Department of Pediatrics, County Hospital, Kecskemét, Hungary.
Petö
J
J
Makáry
A
A
Tímár
S
S
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D012306:Risk; D013928:Thromboxane A2 / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood*
D013929:Thromboxane B2; D013928:Thromboxane A2; D002784:Cholesterol