Growth inhibitory and differentiating effects of sodium butyrate on human neuroblastoma cells in culture.
The effect of sodium butyrate (NaB) on cell growth and expression of morphological and biochemical properties was examined in the human neuroblastoma cell lines AF8 and SJ-N-KP. The obtained data show that NaB induced a marked growth inhibition and morphological differentiation, while it was ineffective in inducing biochemical differentiation.
Rocchi
P
P
Istituto di Cancerologia, Università di Bologna, Italy.
Ferreri
A M
AM
Simone
G
G
Granchi
D
D
Paolucci
P
P
Paolucci
G
G
D000110:Acetylcholinesterase / Q000378:metabolism; D000911:Antibodies, Monoclonal; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D009447:Neuroblastoma; D016900:Neurofilament Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D002087:Butyrates; D053379:Chromogranin A; D002864:Chromogranins; D006680:HLA Antigens; D006684:HLA-DR Antigens; D016900:Neurofilament Proteins; D016708:Synaptophysin; D020148:Butyric Acid; D000110:Acetylcholinesterase; D010751:Phosphopyruvate Hydratase