Inhibitory effect of green tea on tumorigenesis by chemicals and ultraviolet light.
Topical application of a green tea polyphenol fraction inhibited 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in CD-1 mice previously initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Oral administration of a green tea infusion as the sole source of liquid sustenance to SKH-1 mice inhibited ultraviolet B light (UVB)-induced sunburn lesions, UVB-induced initiation of skin tumors, UVB-induced formation of skin tumors in mice previously initiated with DMBA, and nitrosodiethylamine-induced forestomach and lung tumors in A/J mice. In addition to inhibiting UVB-induced formation of skin tumors in DMBA-initiated mice, oral administration of green tea markedly decreased tumor size.
Conney
A H
AH
Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08854.
Wang
Z Y
ZY
Huang
M T
MT
Ho
C T
CT
Yang
C S
CS
D000818:Animals; D016588:Anticarcinogenic Agents; D015197:Carcinogenicity Tests; D005260:Female; D005419:Flavonoids; D051379:Mice; D008812:Mice, Hairless; D009369:Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental; D009381:Neoplasms, Radiation-Induced; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D012878:Skin Neoplasms / Q000209:etiology; D013662:Tea / Q000737:chemistry; D014466:Ultraviolet Rays
D016588:Anticarcinogenic Agents; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea