Acute monoblastic leukemia of infancy in Klinefelter's syndrome.
A 7-month-old infant with Klinefelter's syndrome was diagnosed as having acute monoblastic leukemia (AMoL). Chromosome studies of bone marrow at diagnosis showed the karyotype 46,XXY,-Y,t(10;11)(p13;q14). This is the first report of M5A leukemia associated with Klinefelter's syndrome.
Foot
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Department of Paediatric Oncology, Royal Hospital for Sick Children, Bristol, England.
Oakhill
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Kitchen
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D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D007223:Infant; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D007948:Leukemia, Monocytic, Acute / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D008297:Male; D014178:Translocation, Genetic