title: Anaesthetic interaction between thiopentone and ketamine.
abstract: The anaesthetic effect of thiopentone, ketamine and their combinations were studied in 150 patients of ASA Grades I and II. The ability to open eyes on command and purposeful motor response to noxious pressure on the trapezius muscle were used as endpoints of anaesthesia. Dose-response curves for thiopentone, ketamine and their combinations were determined with a probit procedure and compared with isobolographic analysis. The interaction between thiopentone and ketamine was found to be additive for both endpoints of anaesthesia.
authors.affiliation: Department of Anaesthesiology, Soroka Medical Centre, Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Roytblat
authors.forename: J
authors.initials: J
authors.lastname: Katz
authors.forename: V
authors.initials: V
authors.lastname: Rozentsveig
authors.forename: T
authors.initials: T
authors.lastname: Gesztes
authors.forename: E L
authors.initials: EL
authors.lastname: Bradley
authors.forename: I
authors.initials: I
authors.lastname: Kissin
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D007649:Ketamine; D008875:Middle Aged; D011897:Random Allocation; D013874:Thiopental
chemical_list: D007649:Ketamine; D013874:Thiopental