title: Antithrombotic effects of the prostacyclin analogue naxaprostene after oral and intraduodenal application in rabbit carotid artery thrombosis.
abstract: The antithrombotic efficacy of the prostacyclin analogue naxaprostene has been tested in rabbits with copper coil-induced carotid artery thrombosis. With oral pretreatment, 10 mg/kg naxaprostene prevented thrombotic arterial occlusion; with intraduodenal pretreatment the efficacy of naxaprostene was enhanced and 1 mg/kg was sufficient to exert an antithrombotic effect. The final average carotid blood flow at 180 min compared to the flow immediately before thrombus induction was 85 +/- 25% and 47 +/- 18% in animals treated with 10 mg/kg p.o. resp. 1 mg/kg i.d. naxaprostene. Parallel to the antithrombotic effect, naxaprostene inhibited ADP- and collagen-induced fall in circulating platelets. In anesthetized rabbits there was no dissociation between antithrombotic and hypotensive effects of naxaprostene.
authors.affiliation: Grünenthal GmbH, Department of Pharmacology, Aachen, FRG.
authors.forename: J
authors.initials: J
authors.lastname: Schneider
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002341:Carotid Artery Thrombosis / Q000503:physiopathology*; D003094:Collagen / Q000494:pharmacology; D004386:Duodenum; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007441:Intubation, Gastrointestinal; D008297:Male; D011817:Rabbits; D013921:Thrombocytopenia / Q000097:blood
chemical_list: D005343:Fibrinolytic Agents; D000244:Adenosine Diphosphate; C050548:naxaprostene; D003094:Collagen; D011464:Epoprostenol