title: Passive smoking and middle ear effusion among children in day care.
abstract: One hundred thirty-two children who attended a research day-care center were studied to determine whether passive tobacco smoke exposure was associated with an increased rate of otitis media with effusion or with an increased number of days with otitis media with effusion during the first 3 years of life. Based on preliminary studies, a serum cotinine concentration of greater than or equal to 2.5 ng/mL was considered indicative of exposure to tobacco smoke. Otitis media with effusion was diagnosed using pneumatic otoscopy by nurse practitioners and pediatricians who reviewed the children's health status each weekday. The 87 children with serum cotinine concentrations greater than or equal to 2.5 ng/mL had a 38% higher rate of new episodes of otitis media with effusion during the first 3 years of life than the 45 children with lower or undetectable serum cotinine concentrations (incidence density ratio = 1.38, 95% confidence interval 1.21 to 1.56). The average duration of an episode of otitis media with effusion was 28 days in the children with elevated cotinine concentrations and 19 days in the children with lower cotinine concentrations (P less than .01). It is estimated that 8% of the cases of otitis media with effusion in this population and 17.6% of the days with otitis media with effusion may be attributable to exposure to tobacco smoke.
authors.affiliation: Robert Wood Johnson Clinical Scholars Program, University of North Carolina, Chapel Hill.
authors.forename: R A
authors.initials: RA
authors.lastname: Etzel
authors.forename: E N
authors.initials: EN
authors.lastname: Pattishall
authors.forename: N J
authors.initials: NJ
authors.lastname: Haley
authors.forename: R H
authors.initials: RH
authors.lastname: Fletcher
authors.forename: F W
authors.initials: FW
authors.lastname: Henderson
mesh_terms: D000367:Age Factors; D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D015986:Confounding Factors, Epidemiologic; D003367:Cotinine / Q000097:blood; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D010034:Otitis Media with Effusion / Q000150:complications*; D012044:Regression Analysis; D012141:Respiratory Tract Infections / Q000150:complications; D012307:Risk Factors; D013997:Time Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000032:analysis
chemical_list: D014028:Tobacco Smoke Pollution; D003367:Cotinine