Glycosidically bound sialic acid levels as a predictive marker of postoperative adjuvant therapy in gastric cancer.
A group of 293 gastric cancer patients were examined to see if the preoperative value of glycosidically bound sialic acid is a predictor of prognosis and effectiveness of postoperative adjuvant therapy. All patients had gastrectomies and were histologically confirmed to have primary adenocarcinoma of the stomach. Some patients then received either postoperative adjuvant chemotherapy or immunochemotherapy. Patients with sialic acid levels less than 74.5 mg/dl survived significantly longer than those with sialic acid levels of 74.5 mg/dl or of 85.3 mg/dl and over. No significant differences in survival were found among patients treated by gastrectomy alone, gastrectomy plus chemotherapy and gastrectomy plus immunochemotherapy. However, patients with abnormally elevated levels of sialic acid survived significantly longer when they were treated with immunochemotherapy after gastrectomy than those treated by gastrectomy alone or with chemotherapy after gastrectomy. By using Cox's multivariate regression model, pTNM stages, postoperative adjuvant therapy (chemotherapy and immunochemotherapy) and preoperative serum levels of sialic acid were examined as prognostic variables. Postoperative therapy was a significant prognostic variable in patients with abnormally elevated levels of sialic acid. The preoperative serum level of sialic acid is a promising predictive marker of the response to postoperative adjuvant immunochemotherapy.
Ogoshi
K
K
Department of Surgery, Tokai University School of Medicine, Kanagawa, Japan.
Kondoh
Y
Y
Tajima
T
T
Mitomi
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D011509:Proteoglycans / Q000627:therapeutic use; D012794:Sialic Acids / Q000097:blood*; D013274:Stomach Neoplasms / Q000097:blood / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate
D014408:Biomarkers, Tumor; D011509:Proteoglycans; D012794:Sialic Acids; C010770:polysaccharide-K; D019158:N-Acetylneuraminic Acid