Adoptive transfer of the entire gld (generalized lymphoproliferative disease) syndrome in nude beige mice by a single gld thymocyte graft.
C57BL/6 nude beige mice (B6 nubq; no T cell, no NK activity) were used as recipients for the adoptive transfer of thymocytes from B6 gld mice (generalized lymphoproliferative disease) which are a model of systemic lupus erythematous. The [gld----nubg] chimeras showed several similarities with gld control mice including the T cell disorders (lymphoproliferation and Con A-response deficiency of splenocytes) and B cell disorders (hyperglobulinemia and elevated anti-single-stranded DNA antibody titers). This suggests that the gld lymphoproliferative disorder has a thymic origin (and does not result from an abnormally extrathymic T cell development) and that the gld T cells have an essential role for the emergence of the disorders of both the T and B cells.
Froidevaux
S
S
Laboratoire d'immunologie, Université Louis Pasteur, Strasbourg, France.
Rosenblatt
N
N
Loor
F
F
D000375:Aging / Q000276:immunology; D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D004277:DNA, Single-Stranded / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D016219:Immunotherapy, Adoptive; D008232:Lymphoproliferative Disorders / Q000209:etiology*; D051379:Mice; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000637:transplantation*; D013950:Thymus Gland / Q000276:immunology*
D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D007132:Immunoglobulin Isotypes; D007136:Immunoglobulins