[Electron microscopic studies on the effects of irradiation and mitoxantrone hydrochloride (Novantrone), alone and in combination, on cells of Harding-Passey melanoma in monolayer culture].
2 Gy or 4 Gy irradiation of cultured Harding-Passey melanoma cells revealed electronmicroscopically none or little cell damage. 48 hour exposure of cultures to mitoxantrone concentrations of 1 x 10(-8) M or 3.3 x 10(-8) M also exhibited little cell damage. However, combination of these treatments--in comparison with single treatment--resulted in increased cell damage. The present paper describes the extent of Harding-Passey melanoma cell damage following a radiation exposure (2 or 4 Gy) or a mitoxantrone treatment (1 x 10(-8) M or 3 x 10(-8) M) for 48 hours alone or in combination.
Proske
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Klinik für Strahlentherapie, Philipps-Universität Marburg.
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D000818:Animals; D003131:Combined Modality Therapy; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000532:radiotherapy* / Q000648:ultrastructure; D051379:Mice; D008942:Mitoxantrone / Q000494:pharmacology / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure
D008942:Mitoxantrone
Elektronenmikroskopische Untersuchungen zur Wirkung von Röntgenstrahlen und Mitoxantron-Hydrochlorid (Novantron)--allein und in Kombination--auf Harding-Passey-Melanomzellen in Monolayer-Kultur.