Midazolam in treatment of epileptic seizures.
Midazolam (Versed), the first water-soluble benzodiazepine, has had widespread acceptance as a parenteral anxiolitic agent. Its antiepileptic properties were studied in adult patients with good results. Midazolam was administered intramuscularly to 48 children, ages 4 months to 14 years, with 69 epileptic episodes of various types. In all but 5 epileptic episodes, seizures stopped 1-10 min after injection. These results suggest that midazolam administered intramuscularly may be useful in a variety of epileptic seizures during childhood, specifically when attempts to introduce an intravenous line in convulsing children are unsuccessful.
Lahat
E
E
Pediatric Neurology Clinic, Assaf Harofeh Medical Center, Zerifin, Israel.
Aladjem
M
M
Eshel
G
G
Bistritzer
T
T
Katz
Y
Y
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D013036:Spasms, Infantile / Q000188:drug therapy*
D008874:Midazolam