title: Sodium valproate and clonazepam for treatment-resistant panic disorder.
abstract: Sodium valproate (VA) and clonazepam (CLZ) were combined in the treatment of 4 patients with panic disorders (PD) who were resistant to several antipanic drug treatments. A significant improvement was found in the symptomatology of these patients, but relapses occurred when CLZ dosage was reduced. A potentiation of the GABAergic properties of VA and clonazepam is postulated. This combined treatment could be advantageous for some treatment-resistant PD patients but needs to be studied further.
authors.affiliation: University Hospital, Monterrey, Mexico.
authors.forename: A
authors.initials: A
authors.lastname: Ontiveros
authors.forename: R
authors.initials: R
authors.lastname: Fontaine
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy / Q000523:psychology; D002998:Clonazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy* / Q000523:psychology; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D014635:Valproic Acid