title: Effect of endotoxin on cultured chinchilla middle ear epithelium.
abstract: The effect of endotoxin on the growth and morphology of cultured chinchilla middle ear epithelium was examined. Within 24 hours of culture, cells maintained in medium containing endotoxin exhibited dose-dependent morphological changes. The highest concentration of endotoxin (100 mg) resulted in cell death. The growth curve of the cells in culture demonstrated a dose-dependent, significant increase in cell number when endotoxin was added to the medium.
authors.affiliation: Department of Otolaryngology, Ohio State University College of Medicine, Columbus.
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: T F
authors.initials: TF
authors.lastname: DeMaria
authors.forename: C
authors.initials: C
authors.lastname: van Blitterswijk
authors.forename: D J
authors.initials: DJ
authors.lastname: Lim
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002682:Chinchilla; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000502:physiology*; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D012486:Salmonella typhimurium; D014432:Tympanic Membrane / Q000166:cytology / Q000187:drug effects*
chemical_list: D004731:Endotoxins