[Acute renal failure caused by treatment with diuretics and ACE inhibitors in the absence of renal artery stenosis].
The Authors describe a clinical case of a patient affected by arterial hypertension of severe degree (IV grade OMS) that during therapy with ACE inhibitors and diuretics developed acute renal failure that reversed after stopping treatment. The clinical course was quite similar to acute renal failure induced by ACE inhibitors and diuretics in patient with bilateral renal artery stenosis. In interpreting the pathogenesis, the Authors suppose, beside a reductions of effective plasma flow, the coexistence of hyalinosis of renal arterioles. They underline the necessity of monitoring renal function at least in the first weeks of therapy when a treatment with ACE inhibitors and diuretics is started especially in patients with hypertension of high degree and/or reduced renal function.
Camaiti
A
A
I Divisione di Medicina, Ospedale di Pistoia.
Del Rosso
A
A
Federighi
G
G
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D002752:Chlorthalidone / Q000009:adverse effects; D004232:Diuretics / Q000009:adverse effects*; D004656:Enalapril / Q000009:adverse effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007677:Kidney Function Tests; D008297:Male; D012078:Renal Artery Obstruction / Q000150:complications
D000806:Angiotensin-Converting Enzyme Inhibitors; D004232:Diuretics; D004656:Enalapril; D002752:Chlorthalidone
Insufficienza renale acuta da trattamento con diuretici ed ACE inibitori in assenza di stenosi delle arterie renali.