Rapid gastric emptying of an oral glucose solution in type 2 diabetic patients.
Gastric emptying of a liquid glucose meal was measured with scintigraphic techniques in nine recently diagnosed Type 2 diabetic patients and nine sex- and age-matched nondiabetic control subjects. Seven of the nine Type 2 diabetic patients were receiving oral hypoglycemic therapy which was discontinued the evening prior to the study. The other two diabetic patients were taking no medication. The average gastric half-emptying time was 33.6 min (s.e.m. = 3.2) for the diabetic patients and 64.6 min (s.e.m. = 4.2) for the nondiabetic controls (p = 0.0005). These measurements indicate rapid gastric emptying in Type 2 diabetic patients which may contribute to worsening of glucose control in these patients.
Phillips
W T
WT
Department of Radiology, University of Texas Health Science Center, San Antonio 78284-7800.
Schwartz
J G
JG
McMahan
C A
CA
D000284:Administration, Oral; D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012996:Solutions; D013671:Technetium Tc 99m Sulfur Colloid; D013997:Time Factors
D012996:Solutions; D013671:Technetium Tc 99m Sulfur Colloid; D005947:Glucose