Inefficiency of metal chelators to promote recovery of methylmercury inhibited CNS succinic dehydrogenase.
This paper deals with the level of succinic dehydrogenase (SDH) in various locations of the central nervous system (CNS) of rat, treated with methylmercury chloride (MMC) and later with antagonists. None of the CNS areas reveals any effect after 2 days of MMC application, but further treatment causes a linear inhibition of the enzyme with increasing duration of MMC exposure. Maximal inhibition in all regions is exhibited after 15 days of treatment. In absolute terms, the maximal inhibition is observed in the olfactory bulbs and the minimal effect is seen in the spinal cord after 15 days with low and high doses of MMC respectively.
Raghu
K G
KG
Department of Biosciences, Saurashtra University, Rajkot, India.
Kodi
R B
RB
Vijayalakshmi
K
K
Bapu
C
C
Sood
P P
PP
D000818:Animals; D002490:Central Nervous System / Q000201:enzymology*; D002614:Chelating Agents / Q000494:pharmacology*; D008297:Male; D008767:Methylmercury Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D002614:Chelating Agents; D008767:Methylmercury Compounds; D013385:Succinate Dehydrogenase; C004925:methylmercuric chloride