Prostaglandin (PG) E1 and 13,14-dihydro (DH) PGE1 are diminishing radiation-induced arterial damage.
Rabbit abdominal aorta was irradiated with single or repeated doses up to 10 Gy. The rabbits were killed at different time intervals after irradiation. 5 micrograms/kg x 6/hr PGE1 or its biologically active metabolite 13,14-DH-PGE1 were administered either 6 hours before or 6 hours after irradiation. The administration of both PGEs reduced radiation-induced mitotic activity (3H-thymidine incorporation) and extracellular matrix [collagen-(14C-proline) and glycosaminoglycan (35-S-sulphate)]-formation as determined by means of autoradiography. The initial peak increase in vascular PGI2-synthesis was partly abolished, while the long lasting depression was less pronounced. 13,14-DH-PGE1 was only slightly less active as compared to the parent compound. Pre-radiation treatment was more effective than post-irradiation therapy. These findings suggest that both the PGs exert significant radiation-protective actions on the arterial wall.
Neumann
I
I
Department of Nuclear Medicine, University of Vienna, Wilhelm Auerswald Atherosclerosis Research Group (ASF), Austria.
Rogatti
W
W
Virgolini
I
I
Firbas
W
W
Sinzinger
H
H
D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects / Q000528:radiation effects; D001158:Arteries / Q000528:radiation effects*; D001345:Autoradiography; D004307:Dose-Response Relationship, Radiation; D005109:Extracellular Matrix / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D011837:Radiation-Protective Agents; C069881:13,14-dihydroprostaglandin E1; D000527:Alprostadil