[Clinical evaluation of pre-surgical anxiety: changes in plasma levels of the anxiety peptide (diazepam binding inhibitor)].
The score scale of anxiety (STAI, Y, 1-2) and haematic levels of DBI (diazepam binding inhibitor) were used in 48 surgical patients for clinical evaluation of preoperative anxiety, before and after drugs for preoperative medication. After randomization, were clinically and statistically compared 6 groups according to premedicant drugs (diazepam 0.3 mg/kg; flunitrazepam 0.03 mg/kg; saline; prometazine 0.7 mg/kg); before and after preoperative medication were evaluated the anxiety relief with the score scale, haematic levels of DBI and haemodynamics (systolic and diastolic AP and HR). The results show that DBI can objectively measure the anxiety relief, that not are correlate haematic levels of DBI and score scale, that the best benzodiazepines are diazepam (0.3) and flunitrazepam (0.015) and that the prometazine might give anxiety relief for 5-HT antagonist action. Even if there are limits to study (scanty cases, are missing the range and the brain values of DBI and blood test of DBI is slow method) may be useful the use of score scale and haematic levels of DBI in clinical evaluation of preoperative anxiety relief.
Launo
C
C
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Genova.
De Grandi
R
R
Augeri
C
C
Palermo
S
S
Riello
R
R
Germi
M R
MR
Focacci
V
V
Spirandelli
P
P
Riverso
P
P
D000328:Adult; D000368:Aged; D001007:Anxiety / Q000097:blood / Q000188:drug therapy*; D003975:Diazepam / Q000627:therapeutic use; D026261:Diazepam Binding Inhibitor; D005260:Female; D005445:Flunitrazepam / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000097:blood*; D011229:Preanesthetic Medication; D011300:Preoperative Care; D011398:Promethazine / Q000627:therapeutic use; D013514:Surgical Procedures, Operative / Q000523:psychology*
D026261:Diazepam Binding Inhibitor; D009479:Neuropeptides; D005445:Flunitrazepam; D011398:Promethazine; D003975:Diazepam
Valutazione clinica dell'ansia pre-intervento chirurgico: modificazioni dei livelli plasmatici del peptide dell'ansia (DBI).