title: The effect of pre-induction glycopyrronium on the haemodynamic response of elderly patients to anaesthesia with propofol.
abstract: This study investigated whether pretreatment with glycopyrronium can attenuate the hypotension caused by anaesthesia of the elderly with propofol. Twenty elderly patients (77.1 +/- 2.44 years, mean +/- SEM) of ASA physical status 2 or 3 scheduled for elective urological procedures were given glycopyrronium 0 (n = 10) or 5 micrograms.kg-1 (n = 10) in a randomised, double-blind manner, 5 min before induction of anaesthesia with propofol infused at 600 ml.h-1 (average induction dose 1.7 +/- 0.06 mg.kg-1, mean +/- SEM) followed by maintenance with a propofol infusion at 10 mg.kg-1.h-1. Although glycopyrronium significantly increased heart rate (p less than 0.01, ANOVA), the decrease in blood pressure 2 and 5 min after induction was similar in both groups. The study had a power of 80% to detect a 20 mmHg difference in systolic arterial pressure between treatment groups with p less than 0.05.
authors.affiliation: Department of Anaesthesia, University Hospital of South Manchester, Withington Hospital, West Didsbury.
authors.forename: J R
authors.initials: JR
authors.lastname: Sneyd
authors.forename: R
authors.initials: R
authors.lastname: Mayall
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006024:Glycopyrrolate / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000517:prevention & control*; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D011292:Premedication; D015742:Propofol / Q000009:adverse effects
chemical_list: D006024:Glycopyrrolate; D015742:Propofol