title: Platelet PGI2-receptor behaviour change after treatment with acetylsalicylic acid in healthy volunteers.
abstract: After treatment of human platelet membrane fractions with different concentrations of acetylsalicylic acid (ASA) the Iloprost binding capacity (Bmax) and also the dissociation constant (Kd) of the high-affinity PGI2-receptor increased significantly (p less than 0.01, low-affinity receptor only an increase of Bmax, p less than 0.01), whereas only a significant (p less than 0.05) increase of the Kd of the high-affinity receptor was observed for intact platelets.
authors.affiliation: Wilhelm Auerswald Atherosclerosis Research Group (ASF) Vienna, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Böhm
authors.forename: I
authors.initials: I
authors.lastname: Virgolini
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002855:Chromatography, Thin Layer; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin / Q000187:drug effects*
chemical_list: D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin; D001241:Aspirin