title: Blood-brain barrier permeability changes after experimental subarachnoid hemorrhage.
abstract: Basic mechanisms underlying cerebrovascular permeability responses to subarachnoid hemorrhage (SAH) are still to be defined in detail. Previous investigations examining the occurrence of blood-brain barrier (BBB) breakdown after SAH in the experimental setting have yielded conflicting results. In a rat model of SAH, we assessed BBB changes by means of the quantitative [14C]-alpha-aminoisobutyric acid technique. Experiments were carried out on the second day post-SAH. In blood-injected rats [14C]-alpha-aminoisobutyric acid transport across the BBB increased significantly in cerebral cortices and cerebellar gray matter, averaging 1.3 to 1.5 times control values. The present data indicate that SAH induces well-defined changes in BBB function, possibly involved in the pathogenesis of post-SAH cerebral dysfunction in humans. Results reported here have also potential clinical implications for the management of aneurysm patients.
authors.affiliation: Neurosurgical Clinic, University of Messina, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Germanó
authors.forename: D
authors.initials: D
authors.lastname: d'Avella
authors.forename: R
authors.initials: R
authors.lastname: Cicciarello
authors.forename: R L
authors.initials: RL
authors.lastname: Hayes
authors.forename: F
authors.initials: F
authors.lastname: Tomasello
mesh_terms: D000621:Aminoisobutyric Acids / Q000493:pharmacokinetics*; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D002199:Capillary Permeability / Q000502:physiology*; D002250:Carbon Radioisotopes; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*
chemical_list: D000621:Aminoisobutyric Acids; D002250:Carbon Radioisotopes; C100049:2-aminoisobutyric acid