title: The functional relationship between antidromically evoked field responses of the dentate gyrus and mossy fiber reorganization in temporal lobe epileptic patients.
abstract: Field recordings from the dentate granule cell layer of in vitro brain slices of temporal lobe epileptic patients were evoked by antidromic stimulation. Tissue from the same specimen was stained by the Timm-sulfide method to assess the pattern and degree of mossy fiber reorganization into the supragranular layer. A wide range of physiological responses and Timm staining patterns was present across patients. A significant correlation was observed between the abnormality of antidromic responses, reflected by multiple secondary population spikes, and the degree of Timm staining of the supragranular layer. This relationship lends support to the hypothesis that mossy fiber synapses located in the supragranular layer may have functional implications for granule cell excitability in human epileptic tissue.
authors.affiliation: Department of Neurology, University of Pennsylvania Medical School, Philadelphia 19146.
authors.forename: L M
authors.initials: LM
authors.lastname: Masukawa
authors.forename: K
authors.initials: K
authors.lastname: Uruno
authors.forename: M
authors.initials: M
authors.lastname: Sperling
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Connor
authors.forename: L J
authors.initials: LJ
authors.lastname: Burdette
mesh_terms: D000293:Adolescent; D000328:Adult; D048588:Benzoxazines; D004558:Electric Stimulation; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology*; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000502:physiology*; D010078:Oxazines
chemical_list: D048588:Benzoxazines; D010078:Oxazines; C028911:cresyl violet