title: A clinically relevant modification to existing inhaler therapy.
abstract: A modified formulation of inhaled salbutamol and a new inhaler device were studied in a group of 11 moderate-to-severe asthmatic patients. Changes in airway calibre (FEV1, Vmax30) were measured before and after inhalation of the new formulation, and compared with changes following inhalation of conventional salbutamol. A standard Rotahaler was used as a reference for the new inhaler. The study was conducted as a two-part randomized, double-blind cross-over trial. We found a significantly greater bronchodilatation of the larger airways using the modified drug in the Rotahaler. The new inhaler did not show any superiority over the Rotahaler, contrary to expectations from in vitro work. A slightly shorter model may better reflect the in vitro results. The study has implications for inhalation therapy in general.
authors.affiliation: Department of Thoracic Medicine, King's College School of Medicine and Dentistry, London, U.K.
authors.forename: A J
authors.initials: AJ
authors.lastname: Ward
authors.forename: N
authors.initials: N
authors.lastname: Kassem
authors.forename: J M
authors.initials: JM
authors.lastname: Evans
authors.forename: J
authors.initials: J
authors.lastname: Moxham
authors.forename: D
authors.initials: D
authors.lastname: Ganderton
mesh_terms: D000328:Adult; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D004337:Drug Carriers; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers
chemical_list: D004337:Drug Carriers; D000420:Albuterol