title: A two-point volume localized T1 measurement sequence for in vivo spectroscopy using a surface coil.
abstract: A technique for obtaining T1 values from well localized regions using surface coils and with a clinically practicable measurement time is described. The method uses a two-point Inversion-Recovery/Saturation-Recovery (IR/SR) sequence in conjunction with the image-selected in vivo spectroscopy localization scheme. T1 values are obtained by comparing the ratio of peak areas with those in a pre-computed look-up table. The method was tested by measuring the T1s of six calibrated water phantoms doped with different concentrations of gadolinium. This indicated an accuracy of 3% for T1 values in the range 400-1500 ms. 31P spectra and T1 values of Pi, phosphocreatine and alpha-, beta- and gamma-NTP metabolites from the calf muscle of healthy volunteers were obtained with the sequence employing beta 1-insensitive excitation pulses and a surface coil. The T1 values fall within the range of published values obtained by other techniques.
authors.affiliation: CRC Clinical Magnetic Resonance Research Group, Royal Marsden Hospital, Sutton, Surrey, UK.
authors.forename: N M
authors.initials: NM
authors.lastname: Yongbi
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: G S
authors.initials: GS
authors.lastname: Payne
authors.forename: D J
authors.initials: DJ
authors.lastname: Collins
mesh_terms: D003627:Data Interpretation, Statistical; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008961:Models, Structural; D009132:Muscles / Q000737:chemistry; D013997:Time Factors