[The molecular genetics of cystic fibrosis: the delta F508 allele in Mexican families].
We have initiated the screening of the delta F508 cystic fibrosis (CF) mutation in our country basing our study on the polymerase chain reaction technique. In a sample of 10 western and a northeastern Mexican families that have at least one CF affected child, we found a delta F508 frequency of 59.1% among CF chromosomes. This frequency is similar to those reported for Spain. Furthermore, we found a correlation between the delta F508 allele and pancreatic insufficiency. This paper points out the advantage of the polymerase chain reaction technology for the analysis of Mendelian disorders.
Rojas-Martínez
A
A
Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México.
Vázquez-Alemán
R M
RM
Gustincich
S
S
Cantú
J M
JM
Barrera-Saldaña
H A
HA
D000483:Alleles; D003550:Cystic Fibrosis / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008800:Mexico / Q000208:ethnology; D009154:Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction
Genética molecular de la fibrosis quistica: el alelo delta F508 en familias mexicanas.