title: Anterior cruciate ligament replacement with polyester fibre. A long-term study of tissue reactions and joint stability in sheep.
abstract: We excised the anterior cruciate ligament from the left stifle of 24 sheep and replaced it by a polyester fibre implant routed 'over the top' of the femoral condyle and fixed, using grommets and screws. All the joints were sound, and the animals moved normally until they were killed at six, 12 and 24 months after operation. We found that the implants were always covered by host tissue, which matured into bundles with a histological appearance similar to the natural ligament. The implants were joined to the bones by organised fibrous tissue and there was no anchorage loosening. There was no synovitis, but the operated joints showed progressive cartilage degeneration. The reconstructed joints became less stable immediately after operation, but regained normal stability as the neoligaments developed. The neoligaments lost strength with time, despite tissue ingrowth. The good functional, biomechanical, and histological results justify clinical trials of this type of implant.
authors.affiliation: Imperial College, London, England.
authors.forename: A A
authors.initials: AA
authors.lastname: Amis
authors.forename: M
authors.initials: M
authors.lastname: Camburn
authors.forename: S A
authors.initials: SA
authors.lastname: Kempson
authors.forename: W J
authors.initials: WJ
authors.lastname: Radford
authors.forename: A C
authors.initials: AC
authors.lastname: Stead
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D002357:Cartilage Diseases / Q000209:etiology; D005260:Female; D007593:Joint Instability / Q000209:etiology; D007719:Knee Joint / Q000000981:diagnostic imaging; D011091:Polyesters; D019736:Prostheses and Implants / Q000009:adverse effects; D011859:Radiography; D012756:Sheep; D013718:Tensile Strength; D013997:Time Factors
chemical_list: D011091:Polyesters