Individual, but not simultaneous, glucagon and cholecystokinin infusions inhibit feeding in men.
Pancreatic glucagon and cholecystokinin octapeptide (CCK-8) were intravenously infused (1 ml/min for 10 min) alone or in combination beginning 15 min after normal-weight men had eaten a 500-ml tomato soup preload and 5 min before they were served a lunch of macaroni and beef with tomato sauce. Infusion of approximately 3 ng.kg-1.min-1 glucagon or approximately 2 ng.kg-1.min-1 CCK-8 each reduced test meal size. However, simultaneous infusion of these peptide doses reduced meal size less than the sum of the peptides' individual effects. Infusions of approximately 1.5 ng.kg-1.min-1 glucagon or approximately 1 ng.kg-1.min-1 CCK-8 had neither individual nor interactive effects on meal size. Psychophysical ratings failed to detect nonspecific side effects after any of the infusions. That exogenous glucagon and CCK-8 each reduced meal size without side effects suggests that these peptides may participate in the physiological control of human appetite; that their simultaneous infusion resulted in an infra-additive reduction in meal size suggests that they can interact antagonistically.
Geary
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Department of Psychology, Columbia University, New York, New York.
Kissileff
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HR
Pi-Sunyer
F X
FX
Hinton
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V
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004435:Eating / Q000187:drug effects*; D005934:Glucagon / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012649:Self Concept; D012844:Sincalide / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D005934:Glucagon; D012844:Sincalide