Platelet-derived and insulin-like growth factors stimulate regeneration of periodontal attachment in monkeys.
Regeneration of cementum, ligament, bone and new attachment was achieved by introducing mixtures of recombinant human platelet-derived growth factor and insulin-like growth factor into debrided lesions of experimentally induced periodontitis in monkeys. This growth factor therapeutic regimen induced the regeneration of nearly 50% of the lost attachment within 4 weeks. New attachment in some cases included regeneration of horizontally resorbed interdental septa. These observations suggest that predictable, clinically significant gains in new attachment may be possible through the use of highly purified human recombinant growth factors delivered to debrided lesions of adult periodontitis in appropriate, inert carrier vehicles.
Rutherford
R B
RB
University of Connecticut School of Dental Medicine, Farmington, CT.
Niekrash
C E
CE
Kennedy
J E
JE
Charette
M F
MF
D016301:Alveolar Bone Loss / Q000188:drug therapy; D000818:Animals; D003739:Dental Cementum / Q000187:drug effects; D007090:Image Interpretation, Computer-Assisted; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use*; D008252:Macaca fascicularis; D010513:Periodontal Ligament / Q000187:drug effects; D010518:Periodontitis / Q000188:drug therapy*; D010519:Periodontium / Q000187:drug effects*; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012038:Regeneration / Q000187:drug effects; D016037:Single-Blind Method
D010982:Platelet-Derived Growth Factor; D011994:Recombinant Proteins; D007334:Insulin-Like Growth Factor I