Behavioural effects of anatoxin, a potent nicotinic agonist, in rats.
Preliminary behavioural studies with the nicotinic agonist (+)-anatoxin have been carried with procedures sensitive to (-)-nicotine. In experimentally naive rats, (+)-anatoxin decreased locomotor activity; this effect resembled that of (-)-nicotine, but it was not blocked by mecamylamine. In nicotine-tolerant rats, (+)-anatoxin differed from (-)-nicotine because it did not increase locomotion. However, in rats trained to discriminate nicotine from saline in an operant conditioning procedure, (+)-anatoxin produced a partial nicotine-like discriminative stimulus effect that was blocked by mecamylamine, and a decreased rate of responding that was insensitive to mecamylamine. The behavioural profile of (+)-anatoxin differs from that of (-)-nicotine and it can be used for further investigations of CNS nicotinic receptors.
Stolerman
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Department of Psychiatry, Institute of Psychiatry, London, U.K.
Albuquerque
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Garcha
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D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D000087522:Cyanobacteria Toxins; D004192:Discrimination, Psychological / Q000187:drug effects; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D008297:Male; D008387:Marine Toxins / Q000494:pharmacology*; D008464:Mecamylamine / Q000494:pharmacology; D052998:Microcystins; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D051381:Rats; D014326:Tropanes
D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; D005731:Ganglionic Stimulants; D008387:Marine Toxins; D052998:Microcystins; D014326:Tropanes; D008464:Mecamylamine; D009538:Nicotine; C509783:anatoxin a