[Value of corticosteroids in after-care of patients after cataract extraction and lens implantation].
In two double-blind controlled trials the anti-inflammatory effects of dexamethasone were examined in post-cataract extraction eyes after lens implantation in 321 patients. In the first trial, 103 patients were included. 49 eyes received eye-drops with 0.1% dexamethasone and antibiotics, the control-group of 54 eyes received the same antibiotics without any steroids. The follow-up was 2 months. In the case of unexpected complications, the patients dropped out. This was the case in 48% of the steroid-group and in 79% of the control-group. The main reason for this statistically significant difference were inflammatory complications in the control-group, which are difficult to quantify. The incidence of fibrinous reactions was not significantly different in the two groups, probably because of small numbers. In the second trial, we looked for fibrinous reactions. The follow-up was 3 weeks, 218 patients participated. They were divided into three groups: 71 patients received eyedrops with 0.1% dexamethasone 4x daily, 77 patients received the same drops 4x daily up to the fifth postoperative day, from then on 1x daily. 70 patients received the same drops 1x daily. A mild fibrinous reaction was seen in 10% of the high-dose-group, in 6% of the medium-dose-group and in 21% of the low-dose-group. Only the difference between the last two groups is statistically significant. We conclude that the therapy with corticosteroids after cataract extraction and lens implantation may be reduced early in the postoperative course.
Wenzel
M
M
Augenklinik, Rheinisch-Westfälischen Technischen Hochschule Aachen.
Dahlke
C
C
Tahmaz
E
E
Reim
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005549:Foreign-Body Reaction / Q000517:prevention & control; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage*; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000008:administration & dosage*; D011112:Polymyxin B / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D013449:Sulfonamides / Q000008:administration & dosage*
D004338:Drug Combinations; D013449:Sulfonamides; C068732:polymyxin B sulfate, neomycin sulfate, sulfonamide, and hydrocortisone drug combination; D005337:Fibrin; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone
Zur Bedeutung der Kortikosteroide in der Nachsorge von Patienten nach Kataraktextraktion und Linsenimplantation.