Bifunctional antibodies and their potential clinical applications.
Bifunctional antibodies are monovalent, bispecific, antibody-derived molecules. They have been produced by both chemical and biological means. They are thought to have several advantages over monoclonal antibodies in both immunotherapy and immunodiagnosis. Bifunctional antibodies have been shown to be efficient in the targeting of drugs, toxins, radiolabelled haptens and effector cells on to diseased tissues, primarily cancer cells. In addition, bifunctional antibodies have been used to develop novel immunoassays. The full potential of bifunctional antibodies has yet to be realised.
Nolan
O
O
Applied Biochemistry Group, School of Biological Sciences, Dublin City University, Glasnevin, Ireland.
O'Kennedy
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R
D000906:Antibodies / Q000627:therapeutic use*; D000917:Antibody Formation; D000918:Antibody Specificity / Q000276:immunology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D011863:Radioimmunoassay; D016719:Radioimmunodetection
D000906:Antibodies; D000970:Antineoplastic Agents