title: Fetal hydrops.
abstract: Seventy-two fetuses or neonates with non-immune hydrops were examined between 1983 and 1988. The commonest association was chromosome abnormality; 11 fetuses had a 45,X karyotype and 11 autosomal trisomy. Chromosome abnormality was suspected in a further 20 on necropsy findings but chromosome culture was not possible or unsuccessful. In 11 cases there was histological evidence of infection; seven babies had major structural anomalies and six affected fetuses were twins. In six (8%) the cause of hydrops was not determined compared with eight (16%) of cases examined between 1976 and 1982. Hydrops was diagnosed more frequently while the fetus was alive, before 20 weeks' gestation, and associated with chromosome anomaly than found previously.
authors.affiliation: Department of Medical Genetics, Churchill Hospital, Headington, Oxford.
authors.forename: P A
authors.initials: PA
authors.lastname: Boyd
authors.forename: J W
authors.initials: JW
authors.lastname: Keeling
mesh_terms: D002869:Chromosome Aberrations; D004200:Diseases in Twins; D005260:Female; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics; D007239:Infections / Q000150:complications; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014781:Viscera / Q000002:abnormalities