title: Gender differences in correlations of cerebral glucose metabolic rates in young normal adults.
abstract: Correlational analysis of normalized regional cerebral metabolic data obtained by positron emission tomography, in healthy subjects in the 'resting' state (eyes covered, ears plugged) using [18F]2-fluoro-2-deoxy-D-glucose, demonstrated gender differences in patterns of functional associations. Fifteen women and 18 men (less than 40 yr) were scanned with a Scanditronix PC1024-7B tomograph. The brain was divided into 65 regions of interest (ROIs). There were no differences between men and women in global or regional metabolic rates, or in metabolic right-left asymmetries. Although the total number of significant correlations did not differ between men and women, patterns differed: female correlations rF were most positive than male correlations rM more often than rM greater than rF; and most rF greater than rM cases involved left frontal and sensorimotor ROIs, whereas most rM greater than rF cases involved right sensorimotor and occipital ROIs. The findings demonstrate gender differences in the pattern of functional neocortical interactions at the 'resting' state.
authors.affiliation: Laboratory of Neurosciences, National Institute on Aging, NIH, Bethesda, MD 20892.
authors.forename: N P
authors.initials: NP
authors.lastname: Azari
authors.forename: S I
authors.initials: SI
authors.lastname: Rapoport
authors.forename: C L
authors.initials: CL
authors.lastname: Grady
authors.forename: C
authors.initials: C
authors.lastname: DeCarli
authors.forename: J V
authors.initials: JV
authors.lastname: Haxby
authors.forename: M B
authors.initials: MB
authors.lastname: Schapiro
authors.forename: B
authors.initials: B
authors.lastname: Horwitz
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D012016:Reference Values; D012727:Sex Characteristics; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed
chemical_list: D005947:Glucose