Mortality of workers employed at organochlorine pesticide manufacturing plants--an update.
A previous mortality study among four organochlorine pesticide manufacturers was updated through 1987. The organochlorine pesticides included chlordane; heptachlor and endrin; aldrin, dieldrin and endrin; and dichlorodiphenyltrichloroethane. The mortality for all causes and all malignant neoplasms at each of the plants was lower than expected. There was a statistically significant increase in liver and biliary tract cancer among workers at plant 3 (5 observed, standardized mortality ratio 393, 95% confidence interval 1.27-9.20). These results are somewhat consistent with experimental animal findings showing benign and malignant tumors of the liver after exposure to aldrin and dieldrin. However, the deaths were due to a mixture of intra- and extra-hepatic tumors, and the dose-response analysis was limited because of the small number of deaths and lack of exposure data. Additional study of this group should include continued follow-up of the total cohort and a case-referent analysis of the deaths from liver and biliary tract cancer.
Brown
D P
DP
Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
D001650:Bile Duct Neoplasms / Q000139:chemically induced / Q000401:mortality*; D002423:Cause of Death; D002561:Cerebrovascular Disorders / Q000139:chemically induced / Q000401:mortality*; D005500:Follow-Up Studies; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000401:mortality*; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000401:mortality*
D006843:Hydrocarbons, Chlorinated