Necrotizing pneumonitis caused by 5-fluorouracil infusion. A complication of a Hickman catheter.
The authors report the case of a patient with a Hickman catheter that migrated into the lung parenchyma. The resultant inadvertent infusion of 5-fluorouracil caused necrotizing chemical pneumonitis. Possible mechanisms of catheter migration include the lateral orientation of the catheter tip and the partial thrombosis of the innominate vein and superior vena cava. The patient recovered but had residual contraction fibrosis of the right upper lobe of the lung.
Manheimer
F
F
Department of Medicine, Department of Veterans Affairs Medical Center, New York, New York.
Aranda
C P
CP
Smith
R L
RL
D000368:Aged; D016121:Brachiocephalic Veins; D002408:Catheters, Indwelling / Q000009:adverse effects*; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects; D005548:Foreign-Body Migration / Q000150:complications*; D006801:Humans; D007262:Infusions, Intravenous / Q000009:adverse effects*; D008168:Lung / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009336:Necrosis; D011014:Pneumonia / Q000139:chemically induced* / Q000473:pathology; D013479:Superior Vena Cava Syndrome / Q000209:etiology; D013927:Thrombosis / Q000209:etiology
D005472:Fluorouracil