title: Quantitative evidence that the genetic basis of human mortality operates at the translation level: a preliminary assessment.
abstract: The dying off of human population cohorts due to different age related diseases rigorously follows stochastically derived rules. The existence of such rules suggests a common, fundamental mechanism for human mortality. We show here, by a simple quantitative analysis, that the progressive loss with age of genetic triplet code information (anticodons) in body cells, as described by the statistics of extremes in order theory, serves as such a mechanism.
authors.affiliation: Barros Research Institute, Holt, MI 48842.
authors.forename: B
authors.initials: B
authors.lastname: Rosenberg
authors.forename: D A
authors.initials: DA
authors.lastname: Juckett
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics; D000595:Amino Acid Sequence; D000926:Anticodon / Q000235:genetics; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D006801:Humans; D008136:Longevity / Q000235:genetics*; D008875:Middle Aged; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009026:Mortality; D014176:Protein Biosynthesis
chemical_list: D000926:Anticodon; D004247:DNA