Deficiency of fibrinolytic enzyme activities in the serum of patients with Alzheimer-type dementia.
Previously we reported that there is a kallikrein deficiency in the cerebral tissue of patients with Alzheimer-type dementia. The present study was performed to investigate protease changes in the serum of these patients. The results showed that the kallikrein activity was normal, but that the activities of plasmin and urokinase were significantly low. The present findings indicate a derangement in the clotting and fibrinolytic systems in Alzheimer patients.
Aoyagi
T
T
Institute of Microbial Chemistry, Tokyo, Japan.
Wada
T
T
Kojima
F
F
Nagai
M
M
Harada
S
S
Takeuchi
T
T
Isse
K
K
Ogura
M
M
Hamamoto
M
M
Tanaka
K
K
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology*; D000595:Amino Acid Sequence; D010450:Endopeptidases / Q000097:blood; D005342:Fibrinolysis; D006801:Humans; D008969:Molecular Sequence Data
D010450:Endopeptidases