Endothelin and sarafotoxin: influence on steroid-regulated motility of rat uterus.
The sarafotoxins (SRTX) and endothelins (ET) were shown to influence the motility of the isolated rat uterus by inducing an increase in the rate and in the maximum tension of the spontaneous rhythmic contractions and a suppression of the relaxation phase of these contractions. Ovariectomized rats, 24 weeks post-operation, show no spontaneous motility of their uteri and the SRTX/ET peptides induce only a slight tonic increase in the uterine tension. Treatment with 17 beta estradiol restores spontaneous motility and sensitivity to the SRTX/ET peptides in all three contraction modes. It is concluded that the influence of the SRTXs and ETs on uterine motility depends on the hormonal status of the animal.
Wollberg
Z
Z
Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.
Shinnar
N
N
Bdolah
A
A
Kochva
E
E
D000818:Animals; D016232:Endothelins / Q000494:pharmacology*; D004958:Estradiol / Q000502:physiology*; D005260:Female; D010052:Ovariectomy; D051381:Rats; D011919:Rats, Inbred Strains; D014590:Uterine Contraction / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014757:Viper Venoms / Q000494:pharmacology*
D016232:Endothelins; D014662:Vasoconstrictor Agents; D014757:Viper Venoms; C057354:sarafotoxins s6; D004958:Estradiol