title: Effect of physiotherapy on the auditory evoked response of paralysed, sedated patients in the intensive care unit.
abstract: Auditory evoked response (AER) was recorded before, during and after physiotherapy in 11 paralysed (atracurium 0.56 (SD) 0.13 mg kg-1 h-1), sedated (propofol 2.2 (1.0) mg kg-1 h-1; fentanyl 4.4 (2.3) micrograms kg-1 h-1) and critically ill patients undergoing ventilation in the intensive care unit (ICU). The latency of the negative wave, NB, was reduced by physiotherapy (mean 44.8 (SD) 7.9 ms before, 41.0 (6.8) ms during (P less than 0.01, non-parametric Friedman test) and 45.6 (6.3) ms after physiotherapy); NB amplitude showed no consistent change (-0.81 (1.4) microV, -0.81 (1.5) microV and -0.71 (1.3) microV, respectively). NB latency responded to patient arousal at constant levels of sedation and this requires further evaluation as a means of monitoring sedation in paralysed patients in the ICU.
authors.affiliation: Department of Anaesthesia, Manchester Royal Infirmary.
authors.forename: J R
authors.initials: JR
authors.lastname: Sneyd
authors.forename: D Y
authors.initials: DY
authors.lastname: Wang
authors.forename: D
authors.initials: D
authors.lastname: Edwards
authors.forename: C J
authors.initials: CJ
authors.lastname: Pomfrett
authors.forename: B R
authors.initials: BR
authors.lastname: Doran
authors.forename: T E
authors.initials: TE
authors.lastname: Healy
authors.forename: B J
authors.initials: BJ
authors.lastname: Pollard
mesh_terms: D000328:Adult; D000368:Aged; D001143:Arousal / Q000502:physiology; D001279:Atracurium; D003422:Critical Care; D005069:Evaluation Studies as Topic; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010243:Paralysis / Q000503:physiopathology*; D026741:Physical Therapy Modalities; D012121:Respiration, Artificial
chemical_list: D006993:Hypnotics and Sedatives; D001279:Atracurium