Early monoaminergic dysfunction.
The chemical anatomy of the Rett syndrome and experimental studies concerning early monoaminergic lesions were overviewed. An early monoaminergic dysfunction is a likely occurrence for the mechanism underlying the Rett syndrome. For assessing the alteration of monoamine neuron system, 1) regional vulnerability, 2) age-dependent vulnerability and 3) interaction between the monoamine neuron systems should be considered.
Takeuchi
Y
Y
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Sawada
T
T
Jenner
P
P
D000818:Animals; D015306:Biogenic Monoamines / Q000032:analysis*; D001923:Brain Chemistry; D005260:Female; D000882:Haplorhini; D006801:Humans; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism; D051381:Rats; D015518:Rett Syndrome / Q000378:metabolism*; D013997:Time Factors
D015306:Biogenic Monoamines