Effect of vinpocetine on red blood cell deformability in stroke patients.
Reduction in red blood cell deformability is a contributory factor in stroke disease, and it has been postulated that red blood cell rigidification may be improved by drug treatment. In this paper the effect of vinpocetine (CAS 42971-09-5) on the deformability of red blood cells from patients with chronic ischemic cerebrovascular disease has been examined. During the administration of vinpocetine for 3 months a significant improvement in red blood cell deformability was observed without adverse effect.
Hayakawa
M
M
Department of Geriatrics, Nagoya University School of Medicine, Japan.
D000368:Aged; D002498:Centrifugation; D002561:Cerebrovascular Disorders / Q000097:blood*; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000009:adverse effects / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000009:adverse effects / Q000494:pharmacology*
D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine