Preliminary evidence that incorporation of 5-fluorouracil into RNA correlates with antitumor response.
A comparative study of two different species of a fluorouracil assay was conducted on 11 patients who had carcinoma that was deemed unresectable after the surgical operation. For these patients FU at a dose of 10 mg/kg was intravenously administered before operation, and portions of the tumors were resected within 120-150 min to assay both the (FU)RNA/RNA and FU/protein. After surgery, all patients were given FU alone either intravenously or orally. The FU, which was in an acid-soluble material (FU/protein), was not related to the antitumor effect of FU. However, the FU in RNA [(FU)RNA/RNA)] was found to be related to the antitumor effect of FU. When the concentration of (FU)RNA/RNA was above approximately 200 ng/mg, FU was effectual in unresectable carcinomas. It is probable that the (FU)RNA/RNA may be more suitable than FU/protein for predicting the antitumor effect of FU.
Matsuoka
H
H
Department of Surgery, Kyushu University, Beppu, Japan.
Ueo
H
H
Sugimachi
K
K
Akiyoshi
T
T
D003110:Colonic Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D005468:Fluorodeoxyuridylate / Q000378:metabolism*; D005472:Fluorouracil / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism*
D012334:RNA, Neoplasm; D005468:Fluorodeoxyuridylate; D005472:Fluorouracil