Alzheimer's amyloid precursor protein accumulates within axonal swellings in human brain lesions.
By using a monoclonal antibody and polyclonal antibodies to human beta amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus with Hallervorden-Spatz disease as well as in or around brain abscesses. The axonal swellings were not immunolabeled with beta protein. These results implied that APP accumulated in spheroids regardless of beta protein depositions.
Ohgami
T
T
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kitamoto
T
T
Tateishi
J
J
D000368:Aged; D016229:Amyloid beta-Peptides / Q000032:analysis*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000911:Antibodies, Monoclonal / Q000276:immunology; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D001922:Brain Abscess / Q000378:metabolism* / Q000473:pathology; D002544:Cerebral Infarction / Q000378:metabolism* / Q000473:pathology; D002648:Child; D006801:Humans; D008875:Middle Aged; D006211:Pantothenate Kinase-Associated Neurodegeneration / Q000378:metabolism* / Q000473:pathology
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D000911:Antibodies, Monoclonal