Environmental risk factors for Alzheimer's disease: their relationship to age of onset and to familial or sporadic types.
Data from a case-control study of Alzheimer's disease (AD) were analysed in relation to age of onset and familial/sporadic status. The analyses were restricted to environmental exposures which might injure the brain. Later-onset AD was found to be positively associated with starvation/malnutrition and with nose-picking and negatively with analgesics, while earlier-onset was associated with physical underactivity and nervous breakdown more than 10 years before. Sporadic AD was associated with starvation/malnutrition and with head injury. These analyses merit replication in other large case-control studies of AD.
Henderson
A S
AS
NH & MRC Social Psychiatry Research Unit, Australian National University, Canberra.
Jorm
A F
AF
Korten
A E
AE
Creasey
H
H
McCusker
E
E
Broe
G A
GA
Longley
W
W
Anthony
J C
JC
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D016022:Case-Control Studies; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D012307:Risk Factors; D012931:Social Environment