title: High-dose gadoteridol in MR imaging of intracranial neoplasms.
abstract: Twelve patients with a high suspicion of brain metastases by previous clinical or radiologic examinations were studied in a phase III investigation with magnetic resonance (MR) imaging at 1.5 T after a bolus intravenous injection of 0.1 mmol/kg gadoteridol followed at 30 minutes by a second bolus injection of 0.2 mmol/kg gadoteridol. All lesions were best demonstrated (showed greatest enhancement) at the 0.3-mmol/kg (cumulative) dose, with image analysis confirming signal intensity enhancement in the majority of cases after the second gadoteridol injection. More lesions were detected with the 0.3-mmol/kg dose than with the 0.1-mmol/kg dose, and more lesions were detected with the 0.1-mmol/kg dose than on precontrast images. In this limited clinical trial, high-dose gadoteridol injection (0.3-mmol/kg cumulative dose) provided improved lesion detection on MR images specifically in intracranial metastatic disease.
authors.affiliation: Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky Medical Center, Lexington 40536-0084.
authors.forename: V M
authors.initials: VM
authors.lastname: Runge
authors.forename: J E
authors.initials: JE
authors.lastname: Kirsch
authors.forename: V J
authors.initials: VJ
authors.lastname: Burke
authors.forename: A C
authors.initials: AC
authors.lastname: Price
authors.forename: K L
authors.initials: KL
authors.lastname: Nelson
authors.forename: G S
authors.initials: GS
authors.lastname: Thomas
authors.forename: B L
authors.initials: BL
authors.lastname: Dean
authors.forename: C
authors.initials: C
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006571:Heterocyclic Compounds; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium