Syntheses and activities of some bactobolin derivatives.
Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus.
Nishimura
Y
Y
Institute of Microbial Chemistry, Tokyo, Japan.
Kondo
S
S
Takeuchi
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000627:therapeutic use; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D016106:Methicillin Resistance; D051379:Mice; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; C025268:bactobolin