Multiple complications of the antiphospholipid syndrome with apparent response to aspirin therapy.
We describe a patient with antiphospholipid antibodies who presented with a rapid progression of hemolytic anemia, thrombocytopenia, central retinal vein thrombosis, 2 cerebral thromboses and pulmonary hemorrhage. She was treated with high dose prednisolone, plasma exchange, high dose intravenous immunoglobulin and began taking cyclophosphamide without evidence of control of disease. However, the anemia and thrombocytopenia appeared to respond rapidly to low dose aspirin and she made a complete recovery without any further complications.
Cohen
M G
MG
Department of Rheumatology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.
Lui
S F
SF
D000328:Adult; D000743:Anemia, Hemolytic / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D001241:Aspirin / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous; D008171:Lung Diseases / Q000188:drug therapy / Q000209:etiology / Q000628:therapy; D010951:Plasma Exchange; D011239:Prednisolone / Q000627:therapeutic use; D012082:Renal Veins; D013921:Thrombocytopenia / Q000188:drug therapy* / Q000209:etiology / Q000628:therapy; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology / Q000628:therapy
D016756:Immunoglobulins, Intravenous; D003520:Cyclophosphamide; D011239:Prednisolone; D001241:Aspirin