Antiatherosclerotic properties of oral cicaprost in hypercholesterolemic rabbits.
The effects of the orally active prostacyclin mimetic cicaprost on morphologic and functional alterations of rabbit aorta was investigated in experimental hypercholesterolemia. Oral cicaprost resulted in a significantly reduced aortic atheromatous plaque formation and partially prevented hypercholesterolemia-induced impairment of endothelium-dependent relaxations. It is concluded that long-term substitution with PGI2 may beneficially influence the progression of atherosclerosis.
Braun
M
M
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.
Sarbia
M
M
Kienbaum
P
P
Hohlfeld
T
T
Weber
A
A
Schrör
K
K
D000284:Administration, Oral; D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D001808:Blood Vessels / Q000473:pathology / Q000503:physiopathology; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000150:complications*; D008055:Lipids / Q000097:blood; D009126:Muscle Relaxation / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D011817:Rabbits
D008055:Lipids; D011464:Epoprostenol; C043867:cicaprost