Familial pulmonary nodular lymphoid hyperplasia.
We describe three persons in one family with diffuse lung infiltrates, digital clubbing, and chronic hypoxia. Elevated immunoglobulin levels and antinuclear antibodies were found in all patients; pathologic findings included hyperplastic lymphoid follicles infiltrating the epithelium of the small airways. These cases may represent a familial systemic autoimmune disorder seen primarily with pulmonary compromise.
Franchi
L M
LM
Pediatric Pulmonary and Critical Care Division, Memorial Miller Children's Hospital, Long Beach, CA 90801.
Chin
T W
TW
Nussbaum
E
E
Riker
J
J
Robert
M
M
Talbert
W M
WM
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001327:Autoimmune Diseases / Q000235:genetics* / Q000473:pathology; D003490:Cyanosis / Q000473:pathology; D005260:Female; D005385:Fingers / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008171:Lung Diseases / Q000235:genetics* / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D011658:Pulmonary Fibrosis / Q000473:pathology
D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G