Role of soluble factors in immune and normal sera in the control of giardiasis due to Giardia lamblia.
Hyperimmune sera (HIS), raised against crude giardia antigen, on in vitro interaction, caused more agglutination of Giardia lamblia trophozoites. Heat inactivated HIS possessed a comparable agglutinating activity as the non-inactivated controls. Non-inactivated normal (unimmunized) serum caused immobilization of Giardia trophozoite, which was checked on heat inactivation. Antibodies in immune sera are mainly responsible for agglutination, whereas the heat labile non-immune components control the mobility of the intestinal parasite.
Srivastava
R K
RK
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
Sethi
N
N
Gupta
N
N
Agarwal
A K
AK
D000371:Agglutination; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D016829:Giardia lamblia / Q000276:immunology* / Q000502:physiology; D005873:Giardiasis / Q000097:blood / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology*; D011817:Rabbits
D007106:Immune Sera