Transplantation of canine malignant lymphomas in the nude and SCID mouse.
Canine lymphoid tumours, which share a number of features with human non-Hodgkin's lymphomas, were grafted in nude or SCID mice. Two (DL.24,DL.31) out of eight lymphomas and two (DL.31,DL.35) out of three lymphomas produced a sub-cutaneous (s.c.) tumour in nude and SCID mice respectively. In all animals, the s.c. tumours that developed at the inoculation site were regularly associated with metastasis to the regional lymph nodes, and also to the spleen, liver and bone marrow in SCID mice. The four transplanted tumours, with a pseudo-diploid canine karyotype, were diffuse large cell lymphomas as the initial dog tumours, and could be immunophenotypically characterized by surface immunoglobulins, MHC-class 2 and Thy-1 antigens. Serially transplanted lymphomas in nude and SCID mice may hence be used for further studies of these tumours.
Baron
T
T
INSERM Unit 218, Centre Léon Bérard, Lyon, France.
Doré
J F
JF
D000818:Animals; D004283:Dog Diseases / Q000276:immunology / Q000473:pathology*; D004285:Dogs; D006801:Humans; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D051379:Mice; D008819:Mice, Nude; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D015995:Prevalence; D012878:Skin Neoplasms / Q000473:pathology; D014183:Transplantation, Heterologous