SH3--an abundant protein domain in search of a function.
Src-homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of beta-sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane-cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.
Musacchio
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European Molecular Biology Laboratory, Heidelberg, Germany.
Gibson
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Lehto
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VP
Saraste
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D000595:Amino Acid Sequence; D000081247:CSK Tyrosine-Protein Kinase; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology; D019061:src-Family Kinases
D010446:Peptide Fragments; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D019061:src-Family Kinases