title: Individual, but not simultaneous, glucagon and cholecystokinin infusions inhibit feeding in men.
abstract: Pancreatic glucagon and cholecystokinin octapeptide (CCK-8) were intravenously infused (1 ml/min for 10 min) alone or in combination beginning 15 min after normal-weight men had eaten a 500-ml tomato soup preload and 5 min before they were served a lunch of macaroni and beef with tomato sauce. Infusion of approximately 3 ng.kg-1.min-1 glucagon or approximately 2 ng.kg-1.min-1 CCK-8 each reduced test meal size. However, simultaneous infusion of these peptide doses reduced meal size less than the sum of the peptides' individual effects. Infusions of approximately 1.5 ng.kg-1.min-1 glucagon or approximately 1 ng.kg-1.min-1 CCK-8 had neither individual nor interactive effects on meal size. Psychophysical ratings failed to detect nonspecific side effects after any of the infusions. That exogenous glucagon and CCK-8 each reduced meal size without side effects suggests that these peptides may participate in the physiological control of human appetite; that their simultaneous infusion resulted in an infra-additive reduction in meal size suggests that they can interact antagonistically.
authors.affiliation: Department of Psychology, Columbia University, New York, New York.
authors.forename: N
authors.initials: N
authors.lastname: Geary
authors.forename: H R
authors.initials: HR
authors.lastname: Kissileff
authors.forename: F X
authors.initials: FX
authors.lastname: Pi-Sunyer
authors.forename: V
authors.initials: V
authors.lastname: Hinton
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004435:Eating / Q000187:drug effects*; D005934:Glucagon / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D012649:Self Concept; D012844:Sincalide / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D005934:Glucagon; D012844:Sincalide