title: Growth hormone therapy in achondroplasia.
abstract: A pilot study was carried out to examine the safety and efficacy of recombinant human growth hormone for growth-promoting therapy of achondroplasia. The data suggest that the agent in doses used to treat non-GH-deficient forms of short stature (0.3 mg/kg/wk) modestly increases overall height velocity in some children with achondroplasia. The effect was seen mainly in children with the lowest growth velocities prior to treatment. No untoward effects were noted. Several questions were raised that require further study.
authors.affiliation: Department of Pediatrics, University of Texas Medical School, Houston 77225.
authors.forename: W A
authors.initials: WA
authors.lastname: Horton
authors.forename: J T
authors.initials: JT
authors.lastname: Hecht
authors.forename: O J
authors.initials: OJ
authors.lastname: Hood
authors.forename: R N
authors.initials: RN
authors.lastname: Marshall
authors.forename: W V
authors.initials: WV
authors.lastname: Moore
authors.forename: J G
authors.initials: JG
authors.lastname: Hollowell
mesh_terms: D000130:Achondroplasia / Q000188:drug therapy*; D001827:Body Height / Q000187:drug effects; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone