Platelet PGI2-receptor behaviour change after treatment with acetylsalicylic acid in healthy volunteers.
After treatment of human platelet membrane fractions with different concentrations of acetylsalicylic acid (ASA) the Iloprost binding capacity (Bmax) and also the dissociation constant (Kd) of the high-affinity PGI2-receptor increased significantly (p less than 0.01, low-affinity receptor only an increase of Bmax, p less than 0.01), whereas only a significant (p less than 0.05) increase of the Kd of the high-affinity receptor was observed for intact platelets.
Böhm
T
T
Wilhelm Auerswald Atherosclerosis Research Group (ASF) Vienna, Austria.
Virgolini
I
I
Sinzinger
H
H
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002855:Chromatography, Thin Layer; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin / Q000187:drug effects*
D044006:Receptors, Epoprostenol; D011982:Receptors, Prostaglandin; D001241:Aspirin