title: Loss of chromosome 22 in patients with refractory anemia with excess of blasts (RAEB) in transformation and acute leukemia after RAEB.
abstract: We report studies of 12 patients with refractory anemia and excess of blasts in transformation (RAEB-t) and 17 with acute myeloblastic leukemia (AML) after RAEB. Besides chromosome 5 and 7 abnormalities, five patients with complex karyotypic changes had monosomy 22. This association is discussed in relation to the hypothesis of a suppressor gene located on chromosome 22.
authors.affiliation: Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: M
authors.initials: M
authors.lastname: Le Coniat
authors.forename: J
authors.initials: J
authors.lastname: Derré
authors.forename: M A
authors.initials: MA
authors.lastname: Flexor
mesh_terms: D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics* / Q000473:pathology; D001752:Blast Crisis / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy