Delayed hypersensitivity to diltiazem in two patients.
We report two cases of cutaneous adverse reactions during treatment with diltiazem. Both patients developed wide-spread, pruriginous, erythematous, maculopapular eruptions with fever and facial angioedema, 48 to 72 hours after starting diltiazem. Delayed hypersensitivity to diltiazem was suspected and the diagnosis was confirmed by skin patch tests followed by cutaneous biopsy.
Romano
A
A
Istituto di Clinica Medica, Università Cattolica del S. Cuore, Rome, Italy.
Pietrantonio
F
F
Garcovich
A
A
Rumi
C
C
Bellocci
F
F
Caradonna
P
P
Barone
C
C
D000368:Aged; D001706:Biopsy; D004110:Diltiazem / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012882:Skin Tests
D004110:Diltiazem