In utero stem cell therapy.
In utero stem cell transplantation offers the potential for treating a number of genetic disorders. The combination of fetal immunotolerance and fetal marrow space makes the fetus an excellent transplant recipient. Experiments on the mouse, sheep and rhesus monkey have indicated that in utero transplantation is feasible. Human trials are currently beginning.
Diukman
R
R
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California Medical Center, San Francisco 94143-0720.
Golbus
M S
MS
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology / Q000379:methods* / Q000592:standards; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D015672:Erythroid Precursor Cells / Q000637:transplantation*; D005315:Fetal Diseases / Q000276:immunology / Q000628:therapy*; D030342:Genetic Diseases, Inborn / Q000276:immunology / Q000628:therapy*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008253:Macaca mulatta; D051379:Mice; D012756:Sheep; D014019:Tissue Donors; D016896:Treatment Outcome