title: Bone composition measured by x-ray scattering.
abstract: Ten composite samples consisting of cortical bone and adipose tissue, in known proportions, were made. The intensity of monochromatic x-rays (energy 8 keV) scattered by these samples was determined as a function of the modulus of the scattering vector, K. The ratio of the heights of peaks at K values of around 134 and 22 nm-1 provided a measure of the ratio of adipose tissue to bone mineral in these samples. This method was then used to determine the ratio of adipose tissue to mineral in samples of trabecular bone from 16 vertebral bodies. The results were correlated with measurements of the bone composition determined by ashing (r = 0.66) and histomorphometry (r = 0.66). Furthermore, the ashing and histomorphometry results were correlated with each other (r = 0.68). The feasibility of using higher energy x-rays (35-80 keV) for obtaining the same information from bone within the body is briefly discussed.
authors.affiliation: Department of Medical Biophysics, University of Manchester, UK.
authors.forename: M
authors.initials: M
authors.lastname: Newton
authors.forename: D W
authors.initials: DW
authors.lastname: Hukins
authors.forename: G
authors.initials: G
authors.lastname: Harding
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry*; D015519:Bone Density; D001842:Bone and Bones / Q000737:chemistry*; D006801:Humans; D012542:Scattering, Radiation