title: Vaginosonographic velocimetry in uterine arteries before and after administration of beta-mimetics.
abstract: OBJECTIVE
  To investigate the effect of surgical procedures at 15 weeks gestation (amniocentesis or cervical cerclage), with or without post-operative ritodrine prophylaxis, on uterine blood flow velocity waveforms and maternal heart rate.
  
  
  METHODS
  A quasi-randomized observational study.
  
  
  METHODS
  University Department of Obstetrics and Gynaecology, Vienna.
  
  
  METHODS
  Sixty women having a genetic amniocentesis for advanced maternal age and 57 women having elective cervical cerclage for previous preterm labour or recurrent miscarriage.
  
  
  METHODS
  The women in each group were allocated either to receive prophylactic ritodrine postoperatively or to receive no ritodrine treatment. Allocation used the year of birth of the woman (odd years received ritodrine, even years received no treatment). All the women had vaginal ultrasound velocimetry studies in both mainstem uterine arteries through the parametrium before the surgical procedure and again after the procedure. The ritodrine-treated women in the cerclage group received intraveneous ritodrine hydrochloride (0.2 mg/min) and those in the amniocentesis group received 60 mg ritodrine/day orally.
  
  
  METHODS
  Uterine artery blood flow velocity waveform indices: A/B ratio and pulsatility index (PI) and maternal heart rate before and after the surgical procedure.
  
  
  RESULTS
  The only statistically significant difference in haemodynamic values between those obtained before the procedure and those obtained after the procedure with or without prophylactic ritodrine was seen in the women who had cervical cerclage with postoperative intravenous ritodrine. The mean A/B ratio decreased from 2.69 (SD 1.17) to 2.11 (SD 0.44), and the mean PI from 1.62 (SD 0.47) to 1.21 (SD 0.3) and the mean maternal heart rate increased from 82.6 (SD 11.1) to 99.4 (SD 15.7). There were no other statistically significant differences between before and after haemodynamic values.
  
  
  CONCLUSIONS
  There are no clinically relevant effects of amniocentesis and cervical cerclage on uterine blood flow velocity waveforms.
authors.affiliation: Second Department of Obstetrics and Gynaecology, University of Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Deutinger
authors.forename: R
authors.initials: R
authors.lastname: Rudelstorfer
authors.forename: A
authors.initials: A
authors.lastname: Pattermann
authors.forename: G
authors.initials: G
authors.lastname: Bernaschek
mesh_terms: D000328:Adult; D000649:Amniocentesis; D001783:Blood Flow Velocity / Q000187:drug effects; D002584:Cervix Uteri / Q000601:surgery; D005260:Female; D006801:Humans; D011897:Random Allocation; D012312:Ritodrine / Q000494:pharmacology* / Q000627:therapeutic use; D014463:Ultrasonography; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging
chemical_list: D012312:Ritodrine