Interneurons in the rat striatum: relationships between parvalbumin neurons and cholinergic neurons.
A pre-embedding double-labeling immunocytochemical method was used to examine the synaptic relationships between cholinergic neurons and the parvalbumin immunoreactive (PV+) neurons. The PV+ neurons were labeled by silver-intensified colloidal gold particles, and the cholinergic neurons by immunoperoxidase reaction products. Cholinergic and PV+ axon terminals form synapses with both the somata and dendrites of PV+ neurons, as well as unlabeled medium-sized somata with round un-indented nuclei, a typical characteristic of the medium spiny projection neurons. These observations suggest that the PV+ and the cholinergic neurons have converging influences on both the projection neurons and the PV+ interneurons in the striatum.
Chang
H T
HT
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee, Memphis 38163.
Kita
H
H
D000109:Acetylcholine / Q000032:analysis*; D000818:Animals; D003342:Corpus Striatum / Q000737:chemistry* / Q000166:cytology; D007124:Immunoenzyme Techniques; D007395:Interneurons / Q000737:chemistry*; D008297:Male; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010320:Parvalbumins / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D009419:Nerve Tissue Proteins; D010320:Parvalbumins; D000109:Acetylcholine