Some physiological characteristics of (SLN X C3H/He)F1 obese mice.
(SLN x C3H/He)F1 mice of both sexes showed significantly heavier body weights than the parental strains associated with the higher food intake and an accumulation of adipose tissue in the subcutaneous and the abdominal regions. Furthermore, serum levels of free fatty acid and growth hormone of F1 mice were higher and lower, respectively, than those of the parental strains. The results indicate that the obesity of these F1 mice is ascribed to excess food intake and metabolic disorders and they are promising as an animal model for the study of several diseases related to obesity.
Nagasawa
H
H
Experimental Animal Research Laboratory, Meiji University, Kanagawa, Japan.
Naito
T
T
Fujii
Y
Y
Yamamoto
K
K
Ishimoto
S
S
D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002149:Energy Intake; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008820:Mice, Obese / Q000097:blood / Q000235:genetics / Q000502:physiology*; D009765:Obesity / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D011388:Prolactin / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D011388:Prolactin; D013006:Growth Hormone