title: Use of high-dose fluconazole as salvage therapy for cryptococcal meningitis in patients with AIDS.
abstract: Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.
authors.affiliation: Audie L. Murphy Memorial Veterans Hospital, San Antonio, Texas.
authors.forename: A J
authors.initials: AJ
authors.lastname: Berry
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: J R
authors.initials: JR
authors.lastname: Graybill
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000284:Administration, Oral; D000328:Adult; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy / Q000401:mortality
chemical_list: D015725:Fluconazole