Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal.
A total of 47 nonimmune febrile patients from Pikine, Senegal, with greater than 1,000 Plasmodium falciparum asexual forms per microliter whole blood were given 12.5 mg per kg body weight of mefloquine in a single oral dose and were followed up daily until day 7 and also on day 14 of the study. Seven of the patients who vomited, four who had 4-aminoquinolines in their blood, and five dropouts were excluded. Fever and parasitaemia were suppressed within four days until day fourteen in 29 of the 31 remaining patients, including 10 with P. falciparum strains that had a low sensitivity to mefloquine. Two failures were due to poor absorption of mefloquine. The presence of P. falciparum strains with low in vitro susceptibility to mefloquine did not affect, within 14 days, the clinical and parasitological efficacy of a single oral dose mefloquine regimen in patients who had received no previous antimalarial treatment and who did not have partial immune protection.
Hatin
I
I
Centre National de Référence de la Chimiosensibilité du Paludisme, Paris, France.
Trape
J F
JF
Legros
F
F
Bauchet
J
J
Le Bras
J
J
D000293:Adolescent; D000328:Adult; D000634:Aminoquinolines / Q000097:blood; D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D002738:Chloroquine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D016778:Malaria, Falciparum / Q000469:parasitology*; D015767:Mefloquine / Q000097:blood / Q000494:pharmacology*; D010616:Phenanthrenes / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*
D000634:Aminoquinolines; D000962:Antimalarials; D010616:Phenanthrenes; D002738:Chloroquine; C001920:4-aminoquinoline; C023768:halofantrine; D015767:Mefloquine