Gene-dosage mapping of 30 DNA markers on chromosome 21.
Using a slot-blot method for the dosage of single-copy sequences, the copy numbers of 30 chromosome 21 markers were assessed in the blood DNA of 11 patients with partial trisomy or monosomy 21 and in the DNA of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21. The physical order of these markers on chromosome 21 was thereby determined.
Delabar
J M
JM
URA CNRS 1335, Hôpital Necker, Paris, France.
Chettouh
Z
Z
Rahmani
Z
Z
Theophile
D
D
Blouin
J L
JL
Bono
R
R
Kraus
J
J
Barton
J
J
Patterson
D
D
Sinet
P M
PM
D000782:Aneuploidy; D002891:Chromosomes, Human, Pair 21; D004247:DNA / Q000235:genetics*; D015321:Gene Rearrangement; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D005810:Multigene Family; D014314:Trisomy
D005819:Genetic Markers; D004247:DNA