Genetic linkage map of facioscapulohumeral muscular dystrophy and five polymorphic loci on chromosome 4q35-qter.
A genetic map of five polymorphic markers in the area of the facioscapulohumeral muscular dystrophy (FSHD) gene on chromosome 4q35-qter has been constructed. With these five markers, a number of recombinants have been identified that allow ordering of the marker and the disease loci. The most likely locus order and the relative position of the FSHD gene supported by the recombinants is centromere-D4S171-F11-D4S187-D4S163-D4S139-FS HD-telomere. However, at least one recombination event appears to be inconsistent with this order and suggests a location of FSHD proximal to D4S139.
Wijmenga
C
C
MGC-Department of Human Genetics, Leiden University, The Netherlands.
Sandkuijl
L A
LA
Moerer
P
P
van der Boorn
N
N
Bodrug
S E
SE
Ray
P N
PN
Brouwer
O F
OF
Murray
J C
JC
van Ommen
G J
GJ
Padberg
G W
GW
D001483:Base Sequence; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009136:Muscular Dystrophies / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic
D005819:Genetic Markers; D004247:DNA