Inversion (X)(p22q13) in a uterine leiomyoma.
We report a case of uterine leiomyoma which showed a karyotype 46,X,inv(X)(p22q13) as the only clonal change in most of the cells. A few cells had an additional del(7), though del(7) has been found to be a primary change in leiomyomas. These findings indicate that the abnormality involving the X chromosome and particularly Xp22 can be considered as a primary chromosomal abnormality. We discuss the findings together with few reports of cases involving chromosome X in leiomyomas.
Ozisik
Y Y
YY
Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona.
Meloni
A M
AM
Surti
U
U
Davare
J
J
Sandberg
A A
AA
D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000235:genetics*; D014960:X Chromosome