title: Case report: severe pyoderma associated with familial Mediterranean fever--favorable response to colchicine in three patients.
abstract: Familial Mediterranean fever (FMF) is an autosomal recessive disorder that occurs most frequently among Sephardic Jews and Armenians. It is characterized by recurrent episodes of fever, peritonitis, pleuritis, and arthritis. Skin lesions are seen in some patients. Diagnosis of FMF usually is made on clinical grounds only, typically when recurrent attacks of abdominal pain, fever, and arthritis are observed in a patient with an appropriate ethnic background and family history. To date, there are no specific diagnostic laboratory tests for FMF. Three patients with severe recurrent Pyoderma are covered in this report. In all three cases, the cutaneous lesions were associated with clinical manifestations of FMF and responded to colchicine therapy favorably. The importance of such an association and its therapeutic consequences are emphasized.
authors.affiliation: Institute of Hematology, Barzilai Medical Center, Ashkelon, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Lugassy
authors.forename: M
authors.initials: M
authors.lastname: Ronnen
mesh_terms: D000293:Adolescent; D000328:Adult; D003078:Colchicine / Q000627:therapeutic use*; D010505:Familial Mediterranean Fever / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011711:Pyoderma / Q000188:drug therapy* / Q000209:etiology*; D012883:Skin Ulcer / Q000188:drug therapy / Q000209:etiology
chemical_list: D003078:Colchicine