Multiple primary melanomas in a patient with familial-type DNS during clomiphene-induced pregnancy.
A 35-year old woman developed six primary cutaneous melanomas during her third pregnancy. She had received clomiphene treatment for nearly 2 years previously. She developed two more primary melanomas 15 and 21 months after giving birth. All melanomas were histologically associated with preexisting dysplastic naevi. The patient showed the characteristic phenotype of the dysplastic naevus syndrome; a cousin and an aunt were treated for malignant melanoma and the patient's brother had histologically confirmed dysplastic naevi. The course of her first two pregnancies was not complicated by the development of melanomas. We suggest that clomiphene may have played a role in the activation or progression of these 'precursor lesions' into malignant melanoma.
Kuppens
E
E
Department of Dermatology, University Medical Center, Leiden, The Netherlands.
Bergman
W
W
Welvaart
K
K
Bruijn
J A
JA
Scheffer
E
E
D000328:Adult; D002996:Clomiphene / Q000009:adverse effects*; D004416:Dysplastic Nevus Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D008544:Melanocytes / Q000187:drug effects / Q000473:pathology; D008545:Melanoma / Q000139:chemically induced* / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000235:genetics; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000139:chemically induced*; D011644:Puerperal Disorders / Q000139:chemically induced / Q000235:genetics; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000235:genetics
D002996:Clomiphene