Cerebral vascular physiology in hypertensive disease.
Experimental advances during the last decade have greatly expanded our knowledge of mechanisms that control cerebral blood flow. In addition to local metabolites, many other factors are important in control of cerebral blood vessels. During chronic hypertension, several mechanisms of cerebral vascular control are altered, with both beneficial and detrimental consequences. The changes should be considered carefully during treatment of chronic hypertension.
Williams
J L
JL
Cerebrovascular Research Laboratory, Cleveland Clinic Foundation, Ohio.
Furlan
A J
AJ
D001921:Brain / Q000098:blood supply*; D002543:Cerebral Hemorrhage / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology