title: Vimentin expression by Reed-Sternberg cells in Hodgkin's disease.
abstract: The expression of vimentin in Reed-Sternberg cells in 61 samples of Hodgkin's disease (HD) was examined using an avidin-biotin-peroxidase complex technique. Forty biopsies (66%) expressed vimentin, and expression was seen in all subtypes of HD. No immunophenotypic differences between vimentin-positive and vimentin-negative cases were noted. The significance of such expression is unclear, but may be related to the alterations in growth and differentiation that are typical of neoplastic cells.
authors.affiliation: Department of Pathology, University of Sheffield Medical School, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Angel
authors.forename: R A
authors.initials: RA
authors.lastname: Cullen
authors.forename: J H
authors.initials: JH
authors.lastname: Pringle
authors.forename: I
authors.initials: I
authors.lastname: Lauder
mesh_terms: D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016539:Reed-Sternberg Cells / Q000378:metabolism* / Q000473:pathology; D014746:Vimentin / Q000378:metabolism*
chemical_list: D014746:Vimentin