A case of malignant lymphoma accompanied by Klinefelter's syndrome.
A 66-year-old Japanese male with diffuse non-Hodgkin's lymphoma, of the pleomorphic type, complicated with Klinefelter's syndrome is reported. His phisique was characterized by a long arm span, disproportionately longer lower body dimensions and a small sized penis. He had no children. Chromosomal study revealed 47, XXY and hormonal quantification showed hypergonadtropic hypogonadism. Although chemotherapy was administered, his disease took a progressive course and he died. A discussion of chromosomal alteration and oncogenesis and review of the literature are included.
Koyama
M
M
National Sengokuso Hospital, Kaizuka, Japan.
Uejima
K
K
Konishi
T
T
Ishida
M
M
Kato
M
M
Nishigaki
M
M
Mizutani
H
H
Matsumoto
K
K
Kawase
M
M
Tamaki
T
T
D000368:Aged; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008297:Male