[Changes in size of adult renal allografts in pediatric recipients, clinicopathologic study of decreased graft size in infant recipients and hypertrophy, renal growth in older children].
It is presumed that graft size after renal transplantation from adult donor decreases in infant or very young recipient and increases in older recipient. Measurement of graft length, width, parenchymal thickness on intravenous pyelography (IVP) films, measurement of area of Bowman's capsule, glomerulus, capillary tuft and tubule on graft biopsy specimens were compared between 3 months and 1 year after renal transplantation. The graft sizes decreased in recipients below 6 years-old or body height (Ht.) 90 cm and increased in recipients above 6 years-old, Ht. 100 cm. The case of decreased graft size was found a decrease of area of Bowman's capsule, glomerulus, capillary tuft and tubule. We suggest that it is caused by a difference between renal blood flow in infant and in adult. It is suggested that graft hypertrophy depends predominantly on increased tubular size and capillary tuft enlargement occurs prior to glomerular, tubular change. But, an increase in creatinine clearance (Ccr) was not found following graft hypertrophy.
Motoyama
O
O
1st Department of Pediatrics, Toho University School of Medicine.
Nagai
Y
Y
Ohara
T
T
Hasegawa
A
A
D002648:Child; D002675:Child, Preschool; D006801:Humans; D006984:Hypertrophy; D007223:Infant; D007668:Kidney / Q000254:growth & development* / Q000473:pathology; D007674:Kidney Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation / Q000473:pathology*; D014019:Tissue Donors; D014184:Transplantation, Homologous