title: Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
authors.affiliation: Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts, UK.
authors.forename: P
authors.initials: P
authors.lastname: Karran
authors.forename: M
authors.initials: M
authors.lastname: Bignami
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D004249:DNA Damage; D004361:Drug Tolerance / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008745:Methylation; D008780:Methyltransferases / Q000235:genetics* / Q000378:metabolism; D016296:Mutagenesis / Q000235:genetics; D019853:O(6)-Methylguanine-DNA Methyltransferase
chemical_list: D000477:Alkylating Agents; D006147:Guanine; C008449:O-(6)-methylguanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase