title: Prevalence of measles susceptibility in hospital staff. Evidence to support expanding the recommendations of the Immunization Practices Advisory Committee.
abstract: BACKGROUND
  In 1989 and 1990, measles reached epidemic proportions in the United States, including several areas of California. Children's Hospital Oakland (Calif), a major health care provider for children in a measles epidemic area of California, reported 131 cases between 1989 and 1991, the largest number ever reported by that institution. In February 1990, four cases of measles were reported among hospital staff. Continued risk of nosocomial infection prompted the development of a program to ensure that all hospital staff were adequately protected against measles.
  
  
  METHODS
  All hospital employees who were unable to document proof of measles immunity were required to be serologically screened for measles antibody and to be vaccinated against measles if they were determined to be nonimmune. Serologic screening was performed in-house with a commercially available enzyme-linked immunosorbent assay measles antibody test. Dates of birth were recorded for all employees screened. Individuals with negative or repeatedly equivocal results were considered to be nonimmune and were vaccinated with trivalent measles-mumps-rubella vaccine.
  
  
  RESULTS
  Between March and June 1990, 1694 staff were serologically tested for measles antibody. Eighty-nine (5.3%) of the employees were considered to have inadequate immunity. Forty (45%) of these susceptible individuals were born before 1957.
  
  
  CONCLUSIONS
  We conclude that the recommendations of the Immunization Practices Advisory Committee should be expanded to include serologic screening or vaccination of hospital personnel who were born before 1957. Serologic screening of hospital staff may be a reasonable alternative to vaccination under certain circumstances.
authors.affiliation: Children's Hospital Oakland, Calif.
authors.forename: S
authors.initials: S
authors.lastname: Schwarcz
authors.forename: B
authors.initials: B
authors.lastname: McCaw
authors.forename: P
authors.initials: P
authors.lastname: Fukushima
mesh_terms: D003428:Cross Infection / Q000517:prevention & control; D004198:Disease Susceptibility; D006801:Humans; D008403:Mass Screening; D008457:Measles / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology; D009784:Occupational Diseases / Q000453:epidemiology*; D010564:Personnel, Hospital; D015995:Prevalence; D012698:Serologic Tests; D014481:United States / Q000453:epidemiology
chemical_list: D008458:Measles Vaccine