Learning about cancer genes through invertebrate genetics.
Genetic studies in yeast, nematodes and Drosophila are revealing the signal transduction pathways that regulate differentiation and cell proliferation. Some of the critical molecules involved are homologous to proto-oncogenes and others are likely to be analogous to the products of tumor suppressor genes.
Hoffmann
F M
FM
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.
Sternberg
P W
PW
Herskowitz
I
I
D000818:Animals; D002107:Caenorhabditis / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D015398:Signal Transduction