Hereditary cerebral hemorrhage with amyloidosis-Dutch type: a study of fibrinolysis.
In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII:Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII:Ag level in the acute phase is unclear.
Haan
J
J
Department of Neurology, University Hospital Leiden, The Netherlands.
Kluft
C
C
Leebeek
F W
FW
de Bart
A C
AC
Buruma
O J
OJ
Roos
R A
RA
D000686:Amyloidosis / Q000097:blood / Q000150:complications / Q000235:genetics*; D002097:C-Reactive Protein / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000097:blood / Q000150:complications / Q000235:genetics*; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D000979:alpha-2-Antiplasmin / Q000378:metabolism
D000979:alpha-2-Antiplasmin; D005169:Factor VIII; D005340:Fibrinogen; D002097:C-Reactive Protein