title: Distribution of ciprofloxacin in ascitic fluid following administration of a single oral dose of 750 milligrams.
abstract: The penetration of ciprofloxacin into the ascitic fluid of eight patients was studied. Serum and ascitic fluid samples were obtained before and at 1, 2, 3, 6, and 12 h following administration of a single oral dose of 750 mg. Peak levels (mean +/- standard deviation) were 4.0 +/- 0.7 micrograms/ml in serum and 2.6 +/- 0.6 micrograms/ml in ascitic fluid; the areas under the curve (0 to 12 h) were 29.1 +/- 6.5 micrograms.h/ml in serum and 20.7 +/- 5.0 micrograms.h/ml in ascitic fluid. The concentrations that were achieved are well above the MICs of ciprofloxacin for the members of the family Enterobacteriaceae that cause spontaneous bacterial peritonitis.
authors.affiliation: Infectious Disease Unit, E. Wolfson Hospital, Holon, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Dan
authors.forename: T
authors.initials: T
authors.lastname: Zuabi
authors.forename: C
authors.initials: C
authors.lastname: Quassem
authors.forename: H H
authors.initials: HH
authors.lastname: Rotmensch
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001202:Ascitic Fluid / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D002939:Ciprofloxacin