Deoxymulundocandin--a new echinocandin type antifungal antibiotic.
A new echinocandin type antifungal antibiotic, deoxymulundocandin, C48H77N7O15, was isolated from the culture filtrate and mycelia of a fungal culture, Aspergillus sydowii (Bainier and Sartory) Thom and Church var. nov. mulundensis Roy (Culture No. Y-30462). The structure was established by comparative GC-MS analyses of the derivatized acid hydrolysates of deoxymulundocandin and mulundocandin as well as by the high field NMR experiments (COSY, NOESY and DEPT).
Mukhopadhyay
T
T
Microbiology Department, Hoechst India Limited, Mulund, Bombay.
Roy
K
K
Bhat
R G
RG
Sawant
S N
SN
Blumbach
J
J
Ganguli
B N
BN
Fehlhaber
H W
HW
Kogler
H
H
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D054714:Echinocandins; D008401:Gas Chromatography-Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D054714:Echinocandins; D010456:Peptides, Cyclic; C075535:deoxymulundocandin; C052098:mulundocandin