title: Cardiopulmonary, anesthetic, and postanesthetic effects of intravenous infusions of propofol in greyhounds and non-greyhounds.
abstract: The cardiopulmonary, anesthetic, and postanesthetic effects of an IV infusion of the hypnotic agent propofol were assessed in 6 Greyhounds and 7 non-Greyhounds. After IM injection of acetylpromazine and atropine, a bolus injection of propofol sufficient to allow endotracheal intubation (mean +/- SEM = 4.0 +/- 0.3 mg/kg of body weight in Greyhounds; 3.2 +/- 0.1 mg/kg in non-Greyhounds) was administered, followed by continuous infusion at a rate of 0.4 mg/kg/min for 60 minutes, during which time dogs breathed 100% oxygen. In 23% of all dogs (3 of 13), apnea developed after initial bolus administration of propofol. Arterial blood pressure was well maintained in all dogs, but heart and respiratory rates were decreased significantly (P less than 0.05) during the infusion in Greyhounds. In Greyhounds, mild respiratory acidosis developed after 45 minutes, whereas arterial carbon dioxide tension was increased at all times after propofol administration in non-Greyhounds. In all dogs, PCV and total plasma proteins were unaffected by propofol. Rectal temperature decreased during treatment. Muscle tremors were observed in approximately 50% of dogs (in 3 of 6 Greyhounds and 3 of 7 non-Greyhounds) during and after infusion of propofol. Non-Greyhounds lifted their heads, assumed sternal recumbency, and stood 10 +/- 1, 15 +/- 3, and 28 +/- 5 minutes, respectively, after the end of the infusion; in Greyhounds, the corresponding times were 36 +/- 4, 43 +/- 6, and 63 +/- 7 minutes.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
authors.forename: S A
authors.initials: SA
authors.lastname: Robertson
authors.forename: S
authors.initials: S
authors.lastname: Johnston
authors.forename: J
authors.initials: J
authors.lastname: Beemsterboer
mesh_terms: D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000032:analysis; D001831:Body Temperature / Q000187:drug effects; D001947:Breeding; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs / Q000097:blood / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006400:Hematocrit / Q000662:veterinary; D007262:Infusions, Intravenous / Q000662:veterinary; D008297:Male; D010100:Oxygen / Q000097:blood; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
chemical_list: D001798:Blood Proteins; D002245:Carbon Dioxide; D010100:Oxygen; D015742:Propofol