title: Retinoids: uses and abuses.
abstract: There is no doubt that modern retinoids are a two-edged sword. While they appear to normalize many abnormal biologic processes, i.e. modulate cellular differentiation and cellular proliferation, at the same time they can severely "abnormalize" other processes, i.e. embryonic organogenesis. Pharmaceutical ingenuity in separating their toxicity from their efficacy will determine their ultimate value to the therapist.
authors.affiliation: Division of Dermatology, University of Kansas Medical Center, Kansas City 66103.
authors.forename: J
authors.initials: J
authors.lastname: Kalivas
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects; D005260:Female; D006801:Humans; D011247:Pregnancy; D012176:Retinoids / Q000627:therapeutic use* / Q000633:toxicity; D012871:Skin Diseases / Q000188:drug therapy; D014212:Tretinoin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D012176:Retinoids; D014212:Tretinoin