title: [Isospora belli infection in a patient with adult T-cell leukemia].
abstract: An adult T cell leukemia (ATL) accompanied with Isospora belli infection was described. A 65-year-old male was admitted to our hospital because of a two month history of watery diarrhea. On admission, physical examination showed slight pallor but no detectable superficial lymphadenopathies. Hepatosplenomegaly was not observed. Laboratory examination revealed a leukocyte count 5,500/microliters with 10% abnormal lymphoid cells. A majority of the abnormal lymphoid cells expressed both CD 4 and CD 8 antigens. The patient was diagnosed as chronic ATL, since anti-HTLV-1 antibody in his serum and monoclonal integration of HTLV-1 proviral DNA in his peripheral mononuclear cells were detected. Isospora belli was found in his feces thereafter, and trimethoprim/sulfamethoxazole was effective for diarrhea. In Japan, there have been only 9 reported cases of lymphoproliferative disorders (including five ATL patients) accompanied with Isospora belli infection. From the descriptions in those reports, these 9 cases might all be ATL patients.
authors.affiliation: Department of Internal Medicine, Kumamoto National Hospital.
authors.forename: F
authors.initials: F
authors.lastname: Kawano
authors.forename: K
authors.initials: K
authors.lastname: Nishida
authors.forename: H
authors.initials: H
authors.lastname: Kurisaki
authors.forename: A
authors.initials: A
authors.lastname: Tsukamoto
authors.forename: M
authors.initials: M
authors.lastname: Satoh
authors.forename: I
authors.initials: I
authors.lastname: Sanada
authors.forename: T
authors.initials: T
authors.lastname: Shido
authors.forename: S
authors.initials: S
authors.lastname: Obata
authors.forename: K
authors.initials: K
authors.lastname: Kimura
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D000818:Animals; D002908:Chronic Disease; D003048:Coccidiosis / Q000150:complications*; D003967:Diarrhea / Q000209:etiology; D006801:Humans; D007549:Isospora; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D008297:Male