title: [Modulators of intracellular metabolism in the treatment of diseases of the internal ear].
abstract: Stress reactions develop in different organs as a result of the effect of unfavourable factors which increase the differential threshold for men. These derangements mainly occur in the organs where we can observe an inadequacy between high level of metabolism in the cell and instability of energy supply. Under such conditions stress reactions in the cells have the following stages in succession: intensiveness of the lipolysis in mitochondria, accumulation in the cells of fatty acid metabolites, destruction of the membranous apparatus of the cells, increase in the presence of Ca++ in the cells.
authors.forename: E P
authors.initials: EP
authors.lastname: Gaudin'
authors.forename: L Ia
authors.initials: LIa
authors.lastname: Kise
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005227:Fatty Acids / Q000378:metabolism; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007759:Labyrinth Diseases / Q000188:drug therapy* / Q000378:metabolism*; D008066:Lipolysis; D008763:Methylhydrazines / Q000008:administration & dosage / Q000627:therapeutic use*; D008928:Mitochondria / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D002121:Calcium Channel Blockers; D002317:Cardiovascular Agents; D005227:Fatty Acids; D008763:Methylhydrazines; D014815:Vitamins; C050147:3-(2,2,2-trimethylhydrazine)propionate; D002118:Calcium
vernacular_title: Moduliatory vnutrikletochnogo metabolizma v lechenii zabolevaniĭ vnutrennego ukha.