title: Sporeamicin A, a new macrolide antibiotic. III. Biological properties.
abstract: Sporeamicin A is a new erythromycin-type antibiotic isolated from a species of Saccharopolyspora. It was active in vitro against a wide variety of Gram-positive bacteria. In vitro studies indicated that the sporeamicin A was stable in the presence of human serum, although it was bound to serum proteins. Sporeamicin A was effective in the mouse protection test against Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Sporeamicin A attained higher plasma and tissue levels in the rat than did erythromycin stearate.
authors.affiliation: Research Laboratories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Morishita
authors.forename: N
authors.initials: N
authors.lastname: Mutoh
authors.forename: K
authors.initials: K
authors.lastname: Ishizawa
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Yokoiyama
authors.forename: S
authors.initials: S
authors.lastname: Yaginuma
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D004285:Dogs; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests; D051381:Rats; D011919:Rats, Inbred Strains; D013203:Staphylococcal Infections / Q000517:prevention & control; D013290:Streptococcal Infections / Q000517:prevention & control; D014018:Tissue Distribution
chemical_list: D000900:Anti-Bacterial Agents; C075534:sporeamicin A; D004917:Erythromycin