[Quantification of the levels of p24 antigen and antibodies in human immunodeficiency virus infection].
BACKGROUND
Quantification and clinical evaluation of p24 antigen and anti-HIV antibody levels.


METHODS
Follow up of 13 HIV infected patients (53 sera) by determination of p24 antigen, total anti-HIV antibodies, anti-p24 and anti-env antibodies by ELISA and their semiquantitation. IgG and IgM class antibody determination by immunoblot techniques.


RESULTS
The highest levels of p24 have been found in WR 1 and WR 6 stages. Commonly accepted serologic pattern has not been found in 100% of our cases. Western-blot is more sensitive for the detection of anti-p24 antibodies.


CONCLUSIONS
p24 antigen appearance and a decrease in anti-p24 antibody level is related to a worse clinical prognosis. p24 antigen quantification is a usefull test for monitoring AZT therapy in patients suffering from AIDS.
García
F
F
Departamento de Microbiología, Facultad de Medicina, Granada.
Quirós
E
E
Bernal
M C
MC
Alados
J C
JC
González
M I
MI
Maroto
M C
MC
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000188:drug therapy; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D015483:HIV Antibodies / Q000097:blood*; D016655:HIV Core Protein p24 / Q000097:blood*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D012720:Severity of Illness Index; D015215:Zidovudine / Q000627:therapeutic use
D015483:HIV Antibodies; D016655:HIV Core Protein p24; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015215:Zidovudine
Cuantificación de los niveles de antígeno p24 y anticuerpos en la infección por el virus de la inmunodeficiencia humana.