title: Effect of blood alcohol level on recovery from severe closed head injury.
abstract: A retrospective archival study of 129 moderate to severe closed head-injury patients from a university-based rehabilitation hospital was conducted to investigate the effect of blood alcohol level (BAL) at time of trauma on the length of post-traumatic amnesia (PTA), length of hospitalization and cognitive status on clearing PTA. While no statistical significance was obtained for the effect of BAL on length of PTA, a mean difference of 15.4 days between 'no alcohol' and 'intoxicated' patient groups was observed. A low, but significant correlation, r = 0.249, p less than 0.05, indicated that as blood alcohol level increased, time to rehabilitation admission increased. The sex of the patient had a significant effect on length of PTA, BAL and time of recovery variable F (6,81) = 2.468, p less than 0.05. Females experienced longer length of PTA, but had lower BALs than males. Measures of cognitive status on clearing PTA did not show a statistically significant effect of BAL. Results are discussed in terms of mediating variables in the relationship between BAL and the length of acute hospitalization, prolonged PTA in patients with a positive BAL, and potential physiological bases for the interaction among sex, BAL and PTA duration.
authors.affiliation: Department of Psychology, Ohio State University, Columbus 43210.
authors.forename: C P
authors.initials: CP
authors.lastname: Kaplan
authors.forename: J D
authors.initials: JD
authors.lastname: Corrigan
mesh_terms: D000328:Adult; D000425:Alcohol Amnestic Disorder / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation; D000437:Alcoholism / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D016489:Head Injuries, Closed / Q000503:physiopathology* / Q000523:psychology / Q000534:rehabilitation; D006801:Humans; D007902:Length of Stay; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D009483:Neuropsychological Tests; D011595:Psychomotor Agitation / Q000503:physiopathology / Q000523:psychology / Q000534:rehabilitation; D012047:Rehabilitation Centers; D012189:Retrospective Studies
chemical_list: D000431:Ethanol