Artifact formation during gas chromatographic-mass spectrometric analysis of a methylsulfinyl-containing metabolite.
During gas chromatographic-mass spectrometric analysis using a heated injector, 1-methylthio-4-methylsulfinyltetrachlorobenzene degraded to form tetrachlorothioanisole. Similar reductive defunctionalizations have been reported during in vivo metabolisms. Caution should be used to distinguish metabolites from artifacts which may be formed during the analysis of methylsulfoxides.
Huwe
J K
JK
USDA, ARS, Biosciences Research Laboratory, Fargo, ND 58102.
D016477:Artifacts; D002722:Chlorobenzenes / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D013454:Sulfoxides / Q000032:analysis*
D002722:Chlorobenzenes; D013454:Sulfoxides; C033122:1,4-bis(methylthio)-2,3,5,6-tetrachlorobenzene; C031281:pentachloromethylthiobenzene