title: Clinical usefulness of urinary growth hormone measurements in normal and short children according to different expressions of urinary growth hormone data.
abstract: To assess the clinical usefulness of urinary growth hormone (UGH) measurements, a UGH determination technique, including dialysis, ultrafiltration, and measurement by polyclonal-coated tube RIA, was established. Sixty-three short children were studied: 56 idiopathic growth retarded (37 prepubertal and 19 pubertal) and seven prepubertal with classic GH (growth hormone) deficiency. Forty-two healthy children (32 prepubertal and 10 pubertal) served as controls. Two groups of adults were studied: eight with active acromegaly and 11 healthy controls. UGH was measured in 24-h urine samples from all patients and controls. Mean +/- SD UGH excretion expressed as ng/24 h was significantly lower in the GH-deficient group compared with prepubertal growth-retarded and control children (p less than 0.01). No differences were found between UGH excreted by controls and by the growth-retarded groups. Pubertal children excreted significantly higher amounts of GH when UGH was expressed as ng/24 h (p less than 0.02 and p less than 0.03, respectively), but this difference disappeared when UGH was expressed as ng/g creatinine. UGH was significantly higher in acromegalic patients compared with adult controls (p less than 0.001). Differences between day, night, and 24-h UGH were studied in 23 children. UGH in night urine was significantly lower whether expressed as the total amount or as ng/g creatinine. The effect of recombinant hGH administration on UGH was studied in 13 children after 6 and 12 mo of treatment. UGH increased significantly under recombinant hGH treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hormonal Laboratory, Hospital Germans Trias-Pujol, Barcelona, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Granada
authors.forename: A
authors.initials: A
authors.lastname: Sanmartí
authors.forename: A
authors.initials: A
authors.lastname: Lucas
authors.forename: I
authors.initials: I
authors.lastname: Salinas
authors.forename: J M
authors.initials: JM
authors.lastname: Cuatrecasas
authors.forename: M
authors.initials: M
authors.lastname: Foz
authors.forename: A
authors.initials: A
authors.lastname: Carrascosa
authors.forename: L
authors.initials: L
authors.lastname: Audí
mesh_terms: D000172:Acromegaly / Q000652:urine; D000293:Adolescent; D000328:Adult; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy / Q000473:pathology / Q000652:urine*; D013006:Growth Hormone / Q000172:deficiency / Q000627:therapeutic use / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D013006:Growth Hormone