title: Gene-dosage mapping of 30 DNA markers on chromosome 21.
abstract: Using a slot-blot method for the dosage of single-copy sequences, the copy numbers of 30 chromosome 21 markers were assessed in the blood DNA of 11 patients with partial trisomy or monosomy 21 and in the DNA of a patient-derived human-hamster hybrid cell line carrying a microduplication of chromosome 21. The physical order of these markers on chromosome 21 was thereby determined.
authors.affiliation: URA CNRS 1335, Hôpital Necker, Paris, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Delabar
authors.forename: Z
authors.initials: Z
authors.lastname: Chettouh
authors.forename: Z
authors.initials: Z
authors.lastname: Rahmani
authors.forename: D
authors.initials: D
authors.lastname: Theophile
authors.forename: J L
authors.initials: JL
authors.lastname: Blouin
authors.forename: R
authors.initials: R
authors.lastname: Bono
authors.forename: J
authors.initials: J
authors.lastname: Kraus
authors.forename: J
authors.initials: J
authors.lastname: Barton
authors.forename: D
authors.initials: D
authors.lastname: Patterson
authors.forename: P M
authors.initials: PM
authors.lastname: Sinet
mesh_terms: D000782:Aneuploidy; D002891:Chromosomes, Human, Pair 21; D004247:DNA / Q000235:genetics*; D015321:Gene Rearrangement; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D005810:Multigene Family; D014314:Trisomy
chemical_list: D005819:Genetic Markers; D004247:DNA