[Antimicrobial sensitivity of Haemophilus influenzae strains isolated from children].
Antibiotic susceptibility of 1308 Haemophilus sp. strains isolated in children was evaluated over a 6-year period. Based on their source and clinical presentation all strains were divided in three groups. The first group consisted of 1264 strains obtained by throat and nasal swab; the second of 30 mucosal strains isolated in children manifesting non-invasive infection and the third of 14 invasive strains, Haemophilus influenzae(Hi)tip b, isolated from blood, CSF, pleural and synovial effusion. The isolates of the first and the second group demonstrated high susceptibility (90%) to chloramphenicol, erythromycin, and ceftriaxone, lower (70-90%) ampicillin and trimethoprim-sulfamethoxazole and low susceptibility (less than 25%) to penicillin, lincomycin and cefalexin. Invasive strains of Hi tip b were resistant to multiple drugs, showing susceptibility exclusively to chloramphenicol, erythromycin and ceftriaxone. Guidance for the treatment of the invasive and non-invasive infections and chemoprophylaxis are discussed.
Petreska-Sibinovska
D
D
Children's University Hospital, Belgrade.
Milosavljević-Ristić
S
S
Janić
I
I
D002648:Child; D006193:Haemophilus influenzae / Q000187:drug effects / Q000254:growth & development*; D006801:Humans; D008826:Microbial Sensitivity Tests
Antimikrobna osetljivost sojeva Haemophilus influenzae izolovanih od dece.