No effect of cisapride on paracetamol absorption after oral simultaneous administration.
We have measured the effect of oral cisapride on paracetamol absorption in 12 healthy volunteers in a double-blind placebo-controlled study. Volunteers received paracetamol plus placebo, paracetamol plus cisapride 10 mg and paracetamol plus cisapride 20 mg. Mean plasma paracetamol AUC at 60 min were 1070, 1051 and 1031 micrograms.min.ml-1 and maximum paracetamol concentrations were 31.5, 29.3 and 27.4 micrograms.ml-1 respectively (no significant differences). There was no difference also in time to maximum paracetamol concentration [median (range) 30 (15-120), 30 (15-90) and 30 (15-60) min, respectively]. .
Rowbotham
D J
DJ
University Department of Anaesthesia, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Parnacott
S
S
Nimmo
W S
WS
D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D020117:Cisapride; D004311:Double-Blind Method; D004338:Drug Combinations; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*
D004338:Drug Combinations; D010880:Piperidines; D012702:Serotonin Antagonists; D000082:Acetaminophen; D020117:Cisapride