title: [The programmed cell death of murine BW5147 thymoma under the action of dexamethasone].
abstract: By flow cytometry, imitation modelling and biochemical analysis, the mode and kinetics of dexamethasone-treated T-lymphoma cell death were studied. The hormone was shown to induce delays in pre- and postsynthetic phases of the cell cycle and the death of part of cells. A short exposure to dexamethasone reveals its cytostatic rather than cytolytic effect. Following G2/M delay and cytokinesis, part of cells dies. A reduced serum concentration (2%) causes shorter delays in the cell cycle and a more rapid cell death. Dexamethasone stimulates apoptosis which is indicated by internucleosomal DNA fragmentation, and by a coincidence in time of the processes of DNA degradation and increase in the other membrane permeability. These results are discussed in relation to the cell death and proliferation.
authors.forename: I I
authors.initials: II
authors.lastname: Kruman
authors.forename: N P
authors.initials: NP
authors.lastname: Matylevich
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Rochev
authors.forename: I P
authors.initials: IP
authors.lastname: Beletskiĭ
authors.forename: V N
authors.initials: VN
authors.lastname: Afanas'ev
authors.forename: S R
authors.initials: SR
authors.lastname: Umanskiĭ
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects; D003907:Dexamethasone / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D005434:Flow Cytometry; D051379:Mice; D013945:Thymoma / Q000188:drug therapy* / Q000473:pathology; D013953:Thymus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm; D003907:Dexamethasone
vernacular_title: Programmiruemaia gibel' kletok timomy myshi BW5147 pod deĭstviem deksametazona.