title: An HIV positive haemophiliac with acute lymphoblastic leukaemia successfully treated with intensive chemotherapy and syngeneic bone marrow transplantation.
abstract: A 26-year-old HIV positive severe haemophiliac developed Burkitt-type acute lymphoblastic leukaemia with intracranial involvement. He underwent standard combination therapy, and entered complete remission. Syngeneic bone marrow transplantation (BMT) was undertaken; the donor was also HIV positive. The patient died 18 months from transplant of isolated intracranial relapse, with no evidence of systemic relapse. Unlike other types of non-Hodgkin's lymphoma, Burkitt's type occurs in HIV positive patients with relatively normal CD4 cell counts. Remission can be achieved using intensive chemotherapy, and since these patients may otherwise have a reasonable life expectancy, BMT may be appropriate.
authors.affiliation: Department of Haematology, Royal Infirmary of Edinburgh, UK.
authors.forename: M L
authors.initials: ML
authors.lastname: Turner
authors.forename: H G
authors.initials: HG
authors.lastname: Watson
authors.forename: L
authors.initials: L
authors.lastname: Russell
authors.forename: K
authors.initials: K
authors.lastname: Langlands
authors.forename: C A
authors.initials: CA
authors.lastname: Ludlam
authors.forename: A C
authors.initials: AC
authors.lastname: Parker
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D006679:HIV Seropositivity / Q000150:complications; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*
chemical_list: D003561:Cytarabine; D003520:Cyclophosphamide; D008727:Methotrexate