title: Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils.
abstract: The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.
authors.affiliation: First Department of Internal Medicine, Osaka University Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tagaya
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Kitagawa
authors.forename: M
authors.initials: M
authors.lastname: Niinobe
authors.forename: T
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: R
authors.initials: R
authors.lastname: Hata
authors.forename: S
authors.initials: S
authors.lastname: Ogawa
authors.forename: N
authors.initials: N
authors.lastname: Handa
authors.forename: K
authors.initials: K
authors.lastname: Mikoshiba
authors.forename: T
authors.initials: T
authors.lastname: Kamada
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D016923:Cell Death / Q000187:drug effects; D005260:Female; D005849:Gerbillinae; D006207:Half-Life; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology*
chemical_list: D011994:Recombinant Proteins; D013482:Superoxide Dismutase