title: [Follicular bronchiolitis: a pediatric case report].
abstract: A case of bronchiolitis of insidious evolution appearing in an unweened infant aged six months is reported. Initially an acute episode of bronchial obstruction was followed by respiratory failure with failure to thrive. The total inefficacy of conventional treatment (corticosteroids, nebulised and oral bronchodilators) led to assisted ventilation for three weeks, four months after the onset of symptoms. All investigations aimed at achieving a diagnosis were negative and this led to an open lung biopsy. This showed characteristic lesions of bronchiolitis and follicular bronchitis without other parenchymatous disease. With continuous antibiotics and physiotherapy the respiratory status improved, both clinically and radiologically. Amongst the explanations of the pathophysiology of follicular bronchitis they also discussed the existence of heterozygous delta F 508 in their observation to explain the chronicity of the problems. They stress the need to look for a mutation of delta F 508 in infants who present with unexplained obstructive bronchial pathology.
authors.affiliation: Service de Pédiatrie A, Hôtel-Dieu, Clermont-Ferrand.
authors.forename: A
authors.initials: A
authors.lastname: Labbé
authors.forename: P
authors.initials: P
authors.lastname: Déchelotte
authors.forename: I
authors.initials: I
authors.lastname: Creveaux
authors.forename: P
authors.initials: P
authors.lastname: Poitrineau
authors.forename: J
authors.initials: J
authors.lastname: Gaulme
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001706:Biopsy; D001988:Bronchiolitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D013902:Radiography, Thoracic
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Bronchiolite folliculaire: une observation pédiatrique.