Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol.
Acute leukemia cells of the established line CEM-C1 were treated during growth in serum-free medium with various concentrations of trans-trans farnesol. At concentrations ranging from 9.0 to 31.5 microM, farnesol inhibited growth of these cells without causing cell lysis. This effect was preceded by very rapid inhibition of choline incorporation in cellular lipid fraction. The growth inhibitory effect was prevented to a large extent by incubation with phosphatidylcholine or diacylglycerol.
Melnykovych
G
G
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City 66103.
Haug
J S
JS
Goldner
C M
CM
D000080462:Acyclic Monoterpenes; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004075:Diglycerides / Q000494:pharmacology*; D004286:Dolichols / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005204:Farnesol / Q000494:pharmacology*; D006801:Humans; D007536:Isomerism; D007700:Kinetics; D015459:Leukemia-Lymphoma, Adult T-Cell; D010713:Phosphatidylcholines / Q000494:pharmacology*; D013185:Squalene / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology
D000080462:Acyclic Monoterpenes; D004075:Diglycerides; D004286:Dolichols; D010713:Phosphatidylcholines; D013729:Terpenes; D005204:Farnesol; D013185:Squalene; C007836:geraniol; C013965:diolein