Multiple unrelated chromosome abnormalities in a metastatic mucoepidermoid carcinoma of the parotid gland.
We describe cytogenetic findings in a poorly differentiated, metastatic mucoepidermoid carcinoma of the parotid gland. The tumor was characterized by multiple, unrelated chromosome abnormalities. Except for two small aberrant clones showing t(1;7) and t(2;15), respectively, all other abnormal cells showed unique, mostly structural rearrangements peculiar to each cell. No less than 34 different abnormal karyotypes were observed. A similar karyotypic heterogeneity was also described recently in squamous cell carcinomas of the head and neck.
Nordkvist
A
A
Department of Oral Pathology, University of Göteborg, Sweden.
Edström
S
S
Mark
J
J
Stenman
G
G
D002277:Carcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics*