title: [alpha-Interferon in the treatment of essential thrombocythemia].
abstract: Two patients with essential thrombocythemia were successfully treated by administering native alpha-interferon (alpha-IFN). One patient was a 38-year-old man in whom thrombocytosis was found accidentally. His platelet count on admission was 880,000/microliters and megakaryocytes increased. Three million units of alpha-IFN was administered subcutaneously everyday, and the platelet count decreased gradually to about 500,000/microliters within 2 weeks. The other patient was a 66-year-old woman who visited our hospital complaining of tenderness and swelling of the fingertips. Her platelet count was 1,610,000/microliters, and megakaryocytes increased and showed abnormal morphology. Six million units of alpha-IFN was administered subcutaneously every other day. The tenderness and swelling of the fingertips disappeared soon after the beginning of alpha-IFN administration. The platelet count decreased to about 500,000/microliters within 10 days, but she developed itching of the skin over the entire body. Therefore, alpha-IFN treatment was discontinued. It was suggested that alpha-IFN suppresses not only the maturation and proliferation of the progenitors of megakaryocytes but also the production of platelets from megakaryocytes. Administration of alpha-IFN should be considered in treating patients with essential thrombocythemia, because effects appear soon and alpha-IFN does not induce a second malignancy.
authors.affiliation: Department of Hematology and Oncology, Kanto Teishin Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Hashizume
authors.forename: S
authors.initials: S
authors.lastname: Iki
authors.forename: M
authors.initials: M
authors.lastname: Yagisawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ohbayashi
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Urabe
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D010976:Platelet Count; D013920:Thrombocythemia, Essential / Q000097:blood / Q000628:therapy*
chemical_list: D016898:Interferon-alpha