title: [The effect of age and gender on the effect of midazolam as intramuscular premedicant].
abstract: This study was designed to quantify the appropriate dose of midazolam relating to age and gender for intramuscular premedication. Three hundred and eighty-six consecutive patients (15-83 years) received midazolam (2.5-5.5 mg) with atropine 30 minutes prior to surgery. The perioperative effects of midazolam on arterial pressure as well as heart rate, SpO2 and amnesic effects of regional anesthesia were evaluated in patients divided to 10-year age intervals. Reduction of arterial pressure correlated with preanesthetic values (r = 0.515, P less than 0.01). Especially in those over 60 years, we observed significant reductions. Besides, compared with the males, the reduction was smaller in females. On the arrival at the operating room, this reduction recovered slightly, but preanesthetic hypertension was still attenuated effectively. After age 70, the SpO2 was lower, while the amnesic effect during regional anesthesia was significantly prominent. Amnesic effect correlated more with the dose than the dosage determined by body weight. Younger female patients required larger dosage determined by body weight than the corresponding male. As age increases, dose adjustment should be made mostly on the basis of age, and its adjustment on the basis of body weight should be made with great caution. In this study, we determined the appropriate dose of midazolam, 5 mg for those males younger than 60 years and females below 50 years, and 3-3.5 mg for those older than 80 years.
authors.affiliation: Department of Anesthesiology, Kawanishi City Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Tabuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D008875:Middle Aged; D011229:Preanesthetic Medication; D012727:Sex Characteristics
chemical_list: D008874:Midazolam