Mechanism of the polarographic reduction of a new 5-nitrofuran derivative with antibacterial activity.
The reduction at mercury electrodes of a new 5-nitrofuran derivative with antibacterial activity, N2-(5-nitrofurfurylidene)formohydrazide-4-(3,5-dicyanophenyl)-6-ethoxy-2- pyridyl)imide, was studied by conventional, normal pulse, reverse normal pulse and differential pulse polarography in water-dimethylformamide (30%) buffered media. The waves observed, whose number depended on pH, are attributed to the reduction of the nitro group (6 electrons) and the azomethinic unit (4 electrons). The basic mechanisms of the electrode reactions have been deduced from the characteristics of the waves. Conditions for determining the formal potential of the nitroderivative/radical-anion system, a parameter related to pharmacological activity, are also reported.
Garcia Monteagudo
J C
JC
Department of Physical Chemistry, Faculty of Pharmacy, University of Santiago, Spain.
López Fonseca
J M
JM
Crespo
M A
MA
D000890:Anti-Infective Agents / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009581:Nitrofurans / Q000737:chemistry*; D010084:Oxidation-Reduction; D011048:Polarography; D011725:Pyridines / Q000737:chemistry*
D000890:Anti-Infective Agents; D009581:Nitrofurans; D011725:Pyridines; C075683:N(2)-(5-nitrofurfurylidene)formohydrazide-4-(3,5-dicyanophenyl)-6-ethoxy-2-pyridylimide