title: [Detection of mutated ras-oncogene in pancreatic cancers: improved diagnostic possibilities using molecular biology techniques?].
abstract: C-Ki-ras oncogenes have been detected by polymerase chain reaction in the majority of pancreatic carcinomas. The biological role of ras oncogenes in pancreatic carcinogenesis is unknown. This review summarizes the current knowledge of ras oncogenes in pancreatic carcinomas, the different techniques for oncogenes and their possible diagnostic value.
authors.affiliation: Abt. Allgemeine Innere Medizin, Christian-Albrechts-Universität, Kiel.
authors.forename: K H
authors.initials: KH
authors.lastname: Herzig
authors.forename: M
authors.initials: M
authors.lastname: Schäffer
authors.forename: S
authors.initials: S
authors.lastname: Rosewicz
authors.forename: U R
authors.initials: UR
authors.lastname: Fölsch
mesh_terms: D002455:Cell Division / Q000502:physiology; D006801:Humans; D009154:Mutation / Q000235:genetics*; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*
chemical_list: C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)
vernacular_title: Nachweis des mutierten ras-Onkogens in Pankreaskarzinomen: Verbesserung der diagnostischen Möglichkeiten mit Hilfe molekularbiologischer Techniken?