title: [Role of exogenous fibrinogen in the processes of degranulation of thrombocytes stimulated with thrombin. Ultrastructural study using fibrinogen labeled with colloidal gold].
abstract: Using colloidal gold-conjugated fibrinogen (F-Au) it is shown that exogenous fibrinogen can participate in the platelet release reaction. In the absence of F-Au, internal secretory vacuoles readily formed in human platelets stimulated with thrombin, but extrusion of their content was delayed. Upon incubation with F-Au, endocytic channels induced by F-Au-receptor interactions, fused with internal vacuoles, thus establishing spatial communications of the latter with the outer medium.
authors.forename: N V
authors.initials: NV
authors.lastname: Belitser
authors.forename: M G
authors.initials: MG
authors.lastname: Anishchuk
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Veklich
authors.forename: T R
authors.initials: TR
authors.lastname: Smekhova
authors.forename: T M
authors.initials: TM
authors.lastname: Pozdniakova
authors.forename: O V
authors.initials: OV
authors.lastname: Gorkun
authors.forename: T M
authors.initials: TM
authors.lastname: Chernyshenko
authors.forename: E D
authors.initials: ED
authors.lastname: Moroz
mesh_terms: D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D015550:Cell Degranulation / Q000187:drug effects; D005340:Fibrinogen / Q000494:pharmacology*; D006046:Gold; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D013917:Thrombin / Q000494:pharmacology*; D014617:Vacuoles / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D006046:Gold; D005340:Fibrinogen; D013917:Thrombin
vernacular_title: Rol' ékzogennogo fibrinogena v protsessakh degranuliatsii trombotsitov, stimulirovannykh trombinom. Ul'trastrukturnoe issledovanie s primeneniem fibrinogena, mechennogo kolloidnym zolotom.