Possible association of the extended MHC haplotype B44-SC30-DR4 with autism.
We previously reported that the complement C4B null allele appears to be associated with infantile autism. Since the C4B null allele is known to be part of the extended or ancestral haplotype [B44-SC30-DR4], we investigated the incidence of [B44-SC30-DR4] in 21 autistic children and their parents. This extended haplotype was increased by almost six-fold in the autistic subjects as compared with healthy controls. Moreover, the total number of extended haplotypes expressed on chromosomes of autistic subjects was significantly increased as compared with those expressed on chromosomes of healthy subjects. We conclude that a gene related to, or included in, the extended major histocompatibility complex may be associated with autism.
Warren
R P
RP
Center for Persons with Disabilities, Utah State University, Logan 84322.
Singh
V K
VK
Cole
P
P
Odell
J D
JD
Pingree
C B
CB
Warren
W L
WL
DeWitt
C W
CW
McCullough
M
M
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male