title: Myc and Max function as a nucleoprotein complex.
abstract: The Myc family of oncoproteins are thought to regulate proliferation and differentiation in a wide variety of cell types. Recent studies show that Myc proteins form sequence-specific DNA-binding complexes with Max, a new member of the helix-loop-helix leucine zipper protein class. The properties of the Myc-Max complex suggest a mechanism for Myc's function in both normal and neoplastic cell behavior.
authors.affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
authors.forename: E M
authors.initials: EM
authors.lastname: Blackwood
authors.forename: L
authors.initials: L
authors.lastname: Kretzner
authors.forename: R N
authors.initials: RN
authors.lastname: Eisenman
mesh_terms: D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D009698:Nucleoproteins / Q000737:chemistry; D016271:Proto-Oncogene Proteins c-myc / Q000737:chemistry / Q000502:physiology*; D014157:Transcription Factors
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C067850:Myc associated factor X; D009698:Nucleoproteins; D016271:Proto-Oncogene Proteins c-myc; D014157:Transcription Factors