Estrogen receptor imaging with 17 alpha-[123I]iodovinyl-11 beta-methoxyestradiol (MIVE2)--Part II. Preliminary results in patients with breast carcinoma.
17 alpha-[123I]Iodovinyl-11 beta-methoxyestradiol was injected into 19 women: group 1 (n = 8), initial evaluation of breast cancer; group 2, (n = 11) postoperative follow-up including 9 patients with bone metastases. The primary tumor (size: 8-10 mm) was visualized by breast tomoscintigraphy in 2/4 patients of group 1 with high estrogen receptor concentration (162-445 fmol/mg) and was not detectable in 4 patients with low estrogen receptor concentration (6-32 fmol/mg). Axillary lymph node metastases were detected in 1 patient of group 1 and in 1 patient of group 2. In 4 patients of group 2 with previous primary tumor containing estrogen receptors, MIVE2 uptake in bone metastases was demonstrated. MIVE2 scintigraphy is an original, specific and non-invasive method for breast cancer estrogen receptor imaging in primary and in metastatic tumors.
Ribeiro-Barras
M J
MJ
Service de Medecine Nucléaire In Vivo et Ultra-Sons, Hôpital Bretonneau, Faculté de Médecine et de Pharmacie, Tours, France.
Foulon
C
C
Baulieu
J L
JL
Guilloteau
D
D
Bougnoux
P
P
Lansac
J
J
Besnard
J C
JC
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000648:ultrastructure*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000000981:diagnostic imaging / Q000378:metabolism / Q000648:ultrastructure*; D011877:Radionuclide Imaging; D011960:Receptors, Estrogen / Q000032:analysis*; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods
D007457:Iodine Radioisotopes; D011960:Receptors, Estrogen; D004958:Estradiol; C042716:17 alpha-iodovinyl-11 beta-methoxyestradiol