A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens.
The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.
Hara
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Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
Hutchinson
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D000123:Acetyltransferases / Q000235:genetics*; D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D005798:Genes, Bacterial; D007933:Leucomycins / Q000096:biosynthesis*; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013302:Streptomyces / Q000235:genetics*
D007933:Leucomycins; D000123:Acetyltransferases; C026483:midecamycin