title: Comparative studies on acid cholesterol esterase in renal blood vessels and aorta of control and hypercholesterolemic rabbits.
abstract: Decreased acid cholesterol esterase has been linked to cholesteryl ester accumulation and may be fundamental in the development of atherosclerosis. The present study compared cholesterol esterase activity with the accumulation of cholesterol and its esters in aorta, renal artery and renal preglomerular microvessels. Tissue was obtained from white New Zealand rabbits fed either a control or 2%-cholesterol diet for 1 month. Cholesterol esterase was increased in microvessels from cholesterol-fed animals when compared to aorta and renal artery. Cholesterol feeding generally produced an increase in cholesterol and cholesteryl ester accumulation in all vascular tissues. The percent distribution of esterified/total cholesterol in renal microvessels was decreased consistent with the concomitant increase in cholesterol esterase. In contrast, aorta and renal artery exhibited an increase in cholesterol and cholesteryl ester accumulation and an increase in the percent of esterified cholesterol consistent with a decrease in acid cholesterol esterase after cholesterol feeding. The data suggest that renal microvessels, when compared to aorta and renal artery, may be relatively protected from developing atherosclerotic microvascular lesions through an organ-specific increase in acid cholesterol esterase activity.
authors.affiliation: Department of Medicine, University of California, Long Beach.
authors.forename: V S
authors.initials: VS
authors.lastname: Kamanna
authors.forename: S
authors.initials: S
authors.lastname: Vora
authors.forename: D
authors.initials: D
authors.lastname: Roh
authors.forename: M A
authors.initials: MA
authors.lastname: Kirschenbaum
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000201:enzymology* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006937:Hypercholesterolemia / Q000201:enzymology* / Q000378:metabolism; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000201:enzymology / Q000378:metabolism; D011817:Rabbits; D012077:Renal Artery / Q000201:enzymology / Q000378:metabolism; D002787:Sterol Esterase / Q000378:metabolism*
chemical_list: D002788:Cholesterol Esters; D002784:Cholesterol; D002787:Sterol Esterase