Pravastatin and lovastatin similarly reduce serum cholesterol and its precursor levels in familial hypercholesterolaemia.
The hypocholesterolaemic effect of pravastatin 40 mg and lovastatin 40 mg daily has been compared in patients with familial hypercholesterolaemia (FH). Administration of the two drugs was separated by a three-month washout period. The reduction in total serum cholesterol after 1,2 and 4 weeks of treatment was similar after pravastatin (-23%, -32% and -32%) and lovastatin (-23%, -30% and -31%). The serum concentrations of LDL cholesterol were similarly reduced, whilst triglycerides, other lipoproteins, cholestanol and squalene were not altered. The reductions in the serum levels of the cholesterol precursor sterols, delta 8-cholesterol, desmosterol and lathosterol were not significantly different after either drug. The lack of difference suggests that cholesterol synthesis was equally inhibited by the two agents. In addition, the serum content of the plant sterols campesterol and sitosterol tended to be equally increased. The comparability of the increases suggests that the absorption and biliary elimination of the two sterols were equally affected by the two statins. Thus, no difference was found between the effects of pravastatin and lovastatin on the serum levels and metabolic precursors of cholesterol in FH during four weeks of treatment.
Vanhanen
H
H
Second Department of Medicine, University of Helsinki, Finland.
Miettinen
T A
TA
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003897:Desmosterol / Q000097:blood; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000188:drug therapy*; D007536:Isomerism; D008148:Lovastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010840:Phytosterols; D017035:Pravastatin / Q000008:administration & dosage / Q000627:therapeutic use*; D012855:Sitosterols / Q000097:blood; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D010840:Phytosterols; D012855:Sitosterols; D014280:Triglycerides; D003897:Desmosterol; C021273:campesterol; C025473:gamma-sitosterol; C001521:lathosterol; D002784:Cholesterol; D008148:Lovastatin; D017035:Pravastatin; C056855:zymostenol