Effects of stress on adrenal steroidogenesis blockade by aminoglutethimide.
After one week of AG-treatment, the adrenal cortex reveals a marked storage of lipids and cholesterol, as well as a decrease in haematic corticosterone and progesterone levels. On the contrary, when AG-treatment is associated with stress, an increase in plasma corticosterone and progesterone levels occurs, together with a less evident lipidic storage in the adrenal cortex. These results seem to indicate the possibility that, during stress, hypothalamo-hypophysis axis activation is able to remove, at least partially, the adrenal biosynthesis blockade operated by AG-administration.
Ricciardi
M P
MP
Dipartimento di Scienze Anatomiche, Fisiologiche e delle Produzioni Animali, Facoltà di Medicina Veterinaria, Università degli Studi di Pisa, Italy.
Pellegrini
A
A
Grieco
M
M
Marroni
P
P
Materazzi
F
F
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000616:Aminoglutethimide / Q000494:pharmacology*; D000735:Androstenedione / Q000097:blood; D000818:Animals; D047072:Aromatase Inhibitors; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D002786:Cholesterol Side-Chain Cleavage Enzyme / Q000037:antagonists & inhibitors; D003345:Corticosterone / Q000096:biosynthesis* / Q000097:blood; D003864:Depression, Chemical; D004967:Estrogens / Q000096:biosynthesis; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007103:Immobilization; D050356:Lipid Metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011374:Progesterone / Q000096:biosynthesis* / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013250:Steroid Hydroxylases / Q000037:antagonists & inhibitors; D013312:Stress, Physiological / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood
D047072:Aromatase Inhibitors; D004967:Estrogens; D000616:Aminoglutethimide; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; D002784:Cholesterol; D013250:Steroid Hydroxylases; D002786:Cholesterol Side-Chain Cleavage Enzyme; D003345:Corticosterone