title: Etiology of preterm premature rupture of membranes.
abstract: Numerous factors have been indicted as playing a role in causing preterm premature rupture of membranes (PPROM). After discussing the development of the amnion and chorion, this article focuses primarily on the effects that infection, nutrition, smoking, and cervical incompetence have on the fetal membrane and the subsequent advent of PPROM. However, evidence continues to support a multifactorial etiology for this entity, with numerous factors acting in concert.
authors.affiliation: Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus.
authors.forename: P J
authors.initials: PJ
authors.lastname: Shubert
authors.forename: E
authors.initials: E
authors.lastname: Diss
authors.forename: J D
authors.initials: JD
authors.lastname: Iams
mesh_terms: D005321:Extraembryonic Membranes / Q000033:anatomy & histology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology*; D006801:Humans; D009752:Nutritional Status; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012907:Smoking / Q000009:adverse effects