Inhalation of diethylamine--acute nasal effects and subjective response.
Adult volunteers were exposed to 25 ppm (75 mg/m3) diethylamine in a climate chamber for 15 min in order to study the acute nasal reactions to an exposure equivalent to the present threshold limit value-short-term exposure limit. Changes in nasal volume and nasal resistance were measured by acoustic rhinometry and by rhinomanometry. Acute change in nasal volume, usually seen as acute nasal mucosa response to thermal stimuli, was not observed, nor was an acute change in nasal airway resistance. In a subsequent experiment, the aim was to measure acute sensory effects. Exposure to a concentration increasing from 0 to 12 ppm took place for 60 min, equal to an average concentration of 10 ppm (30 mg/m3). A moderate to strong olfactory response and distinct nasal and eye irritation were observed. In spite of considerable individual variation, the results were in agreement with sensory effect estimates obtained from animal studies.
Lundqvist
G R
GR
Institute of Environmental and Occupational Medicine, University of Arhus, Denmark.
Yamagiwa
M
M
Pedersen
O F
OF
Nielsen
G D
GD
D000162:Acoustics; D000280:Administration, Inhalation; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D004048:Diethylamines / Q000008:administration & dosage / Q000633:toxicity*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D009812:Odorants; D012220:Rhinitis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology
D004048:Diethylamines; C034281:diethylamine