Adhesion of Shigella dysenteriae type 1 and Shigella flexneri to guinea-pig colonic epithelial cells in vitro.
Adhesion of bacteria to guinea-pig colonic epithelial cells in vitro was inhibited by fucose with all the four strains tested (two of Shigella dysenteriae type 1 and two of S. flexneri). N-acetyl neuraminic acid and N-acetyl mannosamine also caused inhibition, suggesting a multiplicity of receptors on the epithelial cell. Congo-red binding of the strains correlated with their adhesive ability, whereas haemagglutination of rabbit erythrocytes by the bacteria did not.
Guhathakurta
B
B
National Institute of Cholera and Enteric Diseases, Calcutta, India.
Sasmal
D
D
Datta
A
A
D000818:Animals; D001422:Bacterial Adhesion; D003106:Colon / Q000382:microbiology*; D004848:Epithelium / Q000382:microbiology; D005643:Fucose / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D012762:Shigella dysenteriae / Q000502:physiology*; D012763:Shigella flexneri / Q000502:physiology*
D005643:Fucose