Dual effects of calcium on ATP-sensitive potassium channels of frog skeletal muscle.
The block of ATP-sensitive K+ channels by ATP were studied in inside-out patches of frog toe muscles. Seal formation within Ca(2+)-free Ringer induces many open channels which can be irreversibly blocked by subsequent addition of Ca2+. However, such Ca(2+)-blocked and ATP-blocked channels can be influenced by the addition of ATP and Ca2+: the block by ATP is partially but irreversibly cancelled.
Krippeit-Drews
P
P
I. Physiologisches Institut der Universität des Saarlands, Homburg, Germany.
Lönnendonker
U
U
D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000502:physiology*; D008564:Membrane Potentials; D009132:Muscles / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*; D011893:Rana esculenta
D015221:Potassium Channels; D000255:Adenosine Triphosphate; D002118:Calcium