title: [Histopathological findings in rectal carcinomas undergoing preoperative irradiation combined with chemotherapy].
abstract: To evaluate the utility of preoperative irradiation (42.6 Gy) for rectal cancer, we examined histological specimens of surgically resected tumors, which were treated with (36 cases) or without (39 cases) preoperative irradiation. On the basis of the histological findings, irradiated cases were classified into non-effective group (17 cases) and effective group (19 cases). According to quantitative analysis, cancer gland ratio (CGR) was 31.3% in non-irradiated group, 16.6% in non-effective group and 3.6% in effective group, while fibrosis ratio was 19.9%, 34.4% and 38.6%, respectively. The radiotherapy significantly reduced cancer gland and induced fibrosis. Influencing factors of recurrence in rectal cancer, such as depth of invasion, ew, vessel invasion (ly, v) and lymph node involvements were improved in the irradiated group, especially in effective cases, as compared with the non-irradiated group. In conclusion, preoperative irradiation therapy was thought to contribute to control of local recurrence and result in improvement of survival rate by decreasing several risk factors.
authors.affiliation: First Department of Surgery, School of Medicine, Chiba University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takiguchi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011300:Preoperative Care; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D005641:Tegafur / Q000627:therapeutic use
chemical_list: D005641:Tegafur