Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.
The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity. Esculetine or WEB 2170 antagonists of histamine and PAF, respectively and especially a combination of both can increase the threshold dose of ouabain-induced fibrillation demonstrating an antiarrhythmic effect. BN 52256 a substance with multi-antagonistic properties shows antiarrhythmic effect in this method, too. WEB 2170 and BN 52256 decrease the incidence of ventricular fibrillation after coronary ligation in rats.
Mest
H J
HJ
Department of Pharmacology and Toxicology, Martin Luther University, Halle, Germany.
Rein
T
T
Riedel
A
A
Köpernik
W
W
Braquet
C
C
D000758:Anesthesia; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001381:Azepines / Q000494:pharmacology; D002974:Clemastine / Q000494:pharmacology; D003327:Coronary Disease / Q000150:complications*; D003331:Coronary Vessels / Q000502:physiology; D006168:Guinea Pigs; D016566:Organoselenium Compounds / Q000494:pharmacology*; D010042:Ouabain; D010880:Piperidines / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D014230:Triazoles / Q000494:pharmacology; D014468:Umbelliferones / Q000494:pharmacology; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*
D000889:Anti-Arrhythmia Agents; D001381:Azepines; D016566:Organoselenium Compounds; D010880:Piperidines; D010972:Platelet Activating Factor; D014230:Triazoles; D014468:Umbelliferones; C075674:BN 52256; D010042:Ouabain; D002974:Clemastine; D011433:Propranolol; C063964:bepafant; C007628:esculetin