Genetic analysis of isolation-induced aggression. I. Comparison between closely related inbred mouse strains.
Young adult males of the inbred mouse strains BALB/c, C57BL/6, CBA, C3H/He, and the outbred strain NMRI showed significant interstrain differences for isolation-induced aggression as measured in a standard-opponent test. Additionally, four related inbred strains of common origin (ABG, AB//Halle, ABB, AB//Jena) were studied. ABG and AB//Halle showed nearly no overlap for the trait isolation-induced aggression. Tests of histocompatibility and coat color, as well as mandible measurements, confirmed a close genetic relationship between ABG and AB//Halle. The large difference for isolation-induced aggression between these two closely related strains offers excellent opportunities to search for single gene correlates of aggression.
Schneider
R
R
Institute of Neurobiology and Brain Research, Department of Neurogenetics, Magdeburg, Germany.
Hoffmann
H J
HJ
Schicknick
H
H
Moutier
R
R
D000374:Aggression / Q000523:psychology; D000378:Agonistic Behavior; D000818:Animals; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006649:Histocompatibility Antigens / Q000235:genetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D012934:Social Isolation; D013045:Species Specificity
D005819:Genetic Markers; D006649:Histocompatibility Antigens