Impaired PGI2-stabilization in septic shock patients.
Lipids, lipoproteins, apolipoproteins and prostacyclin-half-life (PGI2-T/2) in vitro were determined in patients, who suffered from severe circulatory shock. Extremely lowered lipids, lipoproteins and apolipoproteins and an extremely shortened PGI2-T/2 were found, in these patients. These findings support the data of Yui and Aoyama that apolipoproteins may be an important coregulator of the biological half-life of PGI2 and thereby contribute to hemostatic dyregulation seen in these patients.
Podolsky
A
A
2nd Department of Internal Medicine, University of Vienna, Austria.
Vichytil
A
A
Pidlich
J
J
Sinzinger
H
H
D001053:Apolipoproteins / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D012772:Shock, Septic / Q000097:blood*
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008055:Lipids; D008074:Lipoproteins; D011464:Epoprostenol