Pathway recognition by neuronal growth cones: genetic analysis of neural cell adhesion molecules in Drosophila.
Genetic analysis has finally come of age in the study of neural cell adhesion molecules and their function during growth cone guidance in Drosophila. Recent studies have shown that fasciclin II, a neural cell adhesion molecule of the immunoglobulin superfamily, functions as a recognition molecule for the MP1 axon pathway, thus serving as the first molecular confirmation for the existence of functional labels on specific axon pathways in the developing organism.
Grenningloh
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Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Goodman
C S
CS
D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D004330:Drosophila; D009420:Nervous System / Q000166:cytology / Q000254:growth & development*; D009434:Neural Pathways / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
D015816:Cell Adhesion Molecules, Neuronal