title: Diffuse leptomeningeal involvement by a ganglioglioma in a child. Case report.
abstract: Gangliogliomas are tumors composed of neuronal and glial elements that typically grow slowly by expansion only. This report describes a 20-month-old girl with a ganglioglioma that extensively involved the subarachnoid space; microscopic foci of tumor were found in the brain and spinal cord. Despite chemotherapy and radiation therapy, the child died 5 months after diagnosis. Molecular genetic analysis showed loss of chromosome 17p DNA sequences in the tumor tissue.
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
authors.forename: M R
authors.initials: MR
authors.lastname: Wacker
authors.forename: P H
authors.initials: PH
authors.lastname: Cogen
authors.forename: J E
authors.initials: JE
authors.lastname: Etzell
authors.forename: L
authors.initials: L
authors.lastname: Daneshvar
authors.forename: R L
authors.initials: RL
authors.lastname: Davis
authors.forename: M D
authors.initials: MD
authors.lastname: Prados
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D013346:Subarachnoid Space / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm