[Effect of superoxide dismutase on mitochondrial function in rats with hemorrhagic shock].
We observed the alterations in mitochondrial function and activity of endogenous SOD, and studied the protective effects of SOD on rats with hemorrhagic shock. It was found that after two hours' shock, RCR in hepatic and kidney mitochondria decreased significantly (liver P less than 0.01, kidney P less than 0.05), the activity of endogenous SOD depressed more or less in samples of blood and mitochondrial fraction (blood P less than 0.01. liver P less than 0.01. kidney P greater than 0.05). Further descent was found in these parameters in the deteriorating process of shock. After the rats were treated with SOD, RCR and activity of endogenous SOD increased considerably. Mere reflow did not affect them remarkably. This results suggest that oxygen-derived free radicals be the important factor impairing mitochondrial function in hemorrhagic shock, and that SOD can effectively ameliorate mitochondrial function.
Hua
J D
JD
First Affiliated Hospital, Second Military Medical College, Shanghai.
D000818:Animals; D007668:Kidney / Q000201:enzymology; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000201:enzymology; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism / Q000627:therapeutic use*
D013482:Superoxide Dismutase