New distinct lethal osteosclerotic bone dysplasia (Raine syndrome).
We report a third case of a rare neonatal lethal sclerotic bone disorder with distinct craniofacial anomalies and striking radiographic and hitherto undescribed histopathologic features. The remarkable similarity between our patient and 2 recently reported infants suggests strongly a distinct entity. We propose the term Raine syndrome as a convenient identification of this disorder.
Kan
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Department of Histopathology, Royal Alexandra Hospital for Children, Sydney, N.S.W., Australia.
Kozlowski
K
K
D005094:Exophthalmos; D005147:Facial Bones / Q000002:abnormalities; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008831:Microcephaly; D010026:Osteosclerosis / Q000151:congenital* / Q000473:pathology; D012886:Skull / Q000002:abnormalities; D013577:Syndrome