title: SH3--an abundant protein domain in search of a function.
abstract: Src-homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of beta-sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane-cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Musacchio
authors.forename: T
authors.initials: T
authors.lastname: Gibson
authors.forename: V P
authors.initials: VP
authors.lastname: Lehto
authors.forename: M
authors.initials: M
authors.lastname: Saraste
mesh_terms: D000595:Amino Acid Sequence; D000081247:CSK Tyrosine-Protein Kinase; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000737:chemistry; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology; D019061:src-Family Kinases
chemical_list: D010446:Peptide Fragments; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D019061:src-Family Kinases