[Choroid plexus cysts in the 2d trimester--an indication for trisomy 18].
The application of high resolution ultrasound in the prenatal diagnosis enables a detailed differentation of the intracerebral structures in the fetus. In a period of 16 months (Jan. 1990-June 1991) we diagnosed at the "Center for prenatal diagnosis and therapy" at the Charité's Hospital in 14 fetuses among 1800 investigated plexus chorioideus cysts. A rapid karyotyping after cordocentesis was performed in 11 cases. In 3 of them a trisomy 18 could be detected. In one fetus having a normal karyotype we could find besides the cysts multiple structural anomalies. In these 4 cases the termination of pregnancy was performed. In the other 10 pregnancies we could observe a spontaneous regression of the plexus cysts. These results suggest that the prenatal diagnosis of plexus chorioideus cysts is a indication for cytogenetic evaluation in order to detect a trisomy 18.
Bollmann
R
R
Abteilung für Pränatale Diagnostik und Therapie, Humboldt Universität zu Berlin.
Chaoui
R
R
Zienert
A
A
Körner
H
H
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000235:genetics; D002831:Choroid Plexus / Q000002:abnormalities* / Q000000981:diagnostic imaging; D002887:Chromosomes, Human, Pair 18; D003560:Cysts / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D014314:Trisomy; D016216:Ultrasonography, Prenatal
Plexus-chorioideus-Zysten im II. Trimenon--ein Hinweiszeichen für eine Trisomie 18.