title: Patterns and predictors of high-risk sexual behavior in female partners of HIV-infected men with hemophilia.
abstract: OBJECTIVE
  To characterize and quantify high-risk heterosexual activity in HIV-discordant couples.
  
  
  METHODS
  Analysis of cross-sectional and longitudinal questionnaire data from 217 HIV-negative female sexual partners of HIV-infected hemophilic men.
  
  
  METHODS
  Comparison of prevalence rates of anal sex, oral sex, vaginal intercourse with or without condoms, and use of other contraceptives between 1985 and 1991. Logistic regression analysis of demographic, sexual and clinical variables to predict unprotected vaginal sex. Actuarial estimates of semi-annual relapse rates to unsafe sex.
  
  
  RESULTS
  The proportion of women at low risk increased from 7 to 69% between 1985 and 1991, mainly because more women were using condoms during all acts of vaginal intercourse. Other contraceptive practices did not change during this time. The proportion engaging in oral or anal sex decreased (from 26 to 13% and 13 to 4%, respectively). Unprotected vaginal sex was more common among women who enrolled earlier, had less education, engaged in oral or anal sex, and among those whose partners had not had AIDS. Unprotected vaginal sex before enrollment was the strongest predictor of this high-risk activity during follow-up. Two-year rates of relapse to high-risk behavior were significantly higher among women who enrolled at high risk compared with those who enrolled at low risk (39 versus 8%, P = 0.005).
  
  
  CONCLUSIONS
  Although high-risk sexual behavior became much less prevalent in this population between 1985 and 1991, many continued to have unprotected vaginal sex occasionally. Counseling efforts should target couples who have been the most sexually active or have less education, and should emphasize not only initial risk reduction but also maintenance of low-risk behavior.
authors.forename: S
authors.initials: S
authors.lastname: Dublin
authors.forename: P S
authors.initials: PS
authors.lastname: Rosenberg
authors.forename: J J
authors.initials: JJ
authors.lastname: Goedert
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D015995:Prevalence; D012044:Regression Analysis; D012309:Risk-Taking; D012725:Sexual Behavior; D012747:Sexual Partners; D011795:Surveys and Questionnaires