title: Effect of DCA administration or endurance training on lactate metabolism in mice during and after exercise.
abstract: The purpose of this study was to investigate the effect of the activation of tissue oxidative capacity by dichloroacetate (DCA) administration or endurance training on oxidative removal of lactate, which is the major pathway of lactate metabolism, in mice during prolonged exercise and after supramaximal exercise. DCA administration significantly decreased the blood lactate concentration and activated the oxidative removal of lactate during prolonged exercise. DCA administration did not change lactate metabolism in mice after supramaximal exercise. Endurance training significantly decreased the blood lactate concentration during prolonged exercise and also activated the oxidative removal of lactate. Endurance training significantly increased the recovery of the blood lactate concentration after supramaximal exercise, while it did not activate the oxidative removal of lactate. These results suggest that the activation of the tissue oxidative capacity decreases the blood lactate concentration and also can activate the oxidative removal of lactate during prolonged exercise, while it does not activate the oxidative removal of lactate after supramaximal exercise.
authors.affiliation: Department of Sports Sciences, College of Arts and Sciences, University of Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Hatta
authors.forename: R
authors.initials: R
authors.lastname: Soma
mesh_terms: D000818:Animals; D003999:Dichloroacetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007773:Lactates / Q000097:blood*; D008297:Male; D051379:Mice; D010805:Physical Conditioning, Animal; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology
chemical_list: D007773:Lactates; D003999:Dichloroacetic Acid