title: Surface expressed heat-shock proteins by stressed or human immunodeficiency virus (HIV)-infected lymphoid cells represent the target for antibody-dependent cellular cytotoxicity.
abstract: The expression of heat-shock proteins (HSP) of the 72,000 MW family by Daudi and H9 lymphoma cells has been investigated by flow cytometry. It has been found that both heat-stressed and chronically human immunodeficiency virus (HIV)-infected lymphomas show an increased expression of heat-shock proteins (HSP). Moreover, murine monoclonal antibody (mAb) against 72,000 MW HSP was able to mediate antibody-dependent cellular cytotoxicity (ADCC) using peripheral blood lymphocytes (PBL) as effector cells. All target cells used in these experiments were efficiently lysed in the presence of anti-HSP antibody suggesting a role of membrane HSP in the elimination of stressed or infected cells.
authors.affiliation: Department of Biology, University of Rome Tor Vergata, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Di Cesare
authors.forename: F
authors.initials: F
authors.lastname: Poccia
authors.forename: A
authors.initials: A
authors.lastname: Mastino
authors.forename: V
authors.initials: V
authors.lastname: Colizzi
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology*; D006360:Heat-Shock Proteins / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D009363:Neoplasm Proteins / Q000032:analysis; D014407:Tumor Cells, Cultured / Q000737:chemistry
chemical_list: D006360:Heat-Shock Proteins; D009363:Neoplasm Proteins