title: [Farquhar disease. Reduced phagocyte function in a 9-year-old girl with erythrophagocytic lymphohistiocytosis].
abstract: We report phagocyte function tests in a female infant with familial hemophagozytotic lymphohistiocytosis. Chemiluminescence and killing of Saccharomyces cerevisiae by monocytes and granulocytes before chemotherapy and in remission were examined. Patients' monocytes and granulocytes showed a markedly reduced chemiluminescence and killing capacity irrespective of the stage of disease.
authors.affiliation: Zentrum für Kinderheilkunde, Heinrich-Heine-Universität Düsseldorf.
authors.forename: H
authors.initials: H
authors.lastname: Schroten
authors.forename: A
authors.initials: A
authors.lastname: Kampmann
authors.forename: M
authors.initials: M
authors.lastname: Sperzel
authors.forename: H
authors.initials: H
authors.lastname: Jürgens
authors.forename: R
authors.initials: R
authors.lastname: Seger
authors.forename: V
authors.initials: V
authors.lastname: Wahn
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D006644:Histiocytes / Q000187:drug effects / Q000276:immunology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007223:Infant; D008163:Luminescent Measurements; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000276:immunology
vernacular_title: M. Farquhar. Verminderte Phagozytenfunktion bei einem 9 Monate alten Mädchen mit erythrophagozytärer Lymphohistiozytose.