title: Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35.
abstract: Fasioscapulohumeral muscular dystrophy (FSHD) has recently been localized to 4q35. We have studied four families with FSHD. Linkage to the 4q35 probes D4S163, D4S139, and D4S171 was confirmed. We found no recombinants helpful in detailed localization of the FSHD gene. Two of our families include males with a rapidly progressive muscle disease that had been diagnosed, on the basis of clinical features, as Duchenne muscular dystrophy. One of these males is available for linkage study and shares the haplotype of his FSHD-affected aunt and cousin.
authors.affiliation: Department of Pediatrics, University of Iowa College of Medicine, Iowa City.
authors.forename: K D
authors.initials: KD
authors.lastname: Mathews
authors.forename: K A
authors.initials: KA
authors.lastname: Mills
authors.forename: E P
authors.initials: EP
authors.lastname: Bosch
authors.forename: V V
authors.initials: VV
authors.lastname: Ionasescu
authors.forename: K R
authors.initials: KR
authors.lastname: Wiles
authors.forename: K H
authors.initials: KH
authors.lastname: Buetow
authors.forename: J C
authors.initials: JC
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D010375:Pedigree