[Isospora belli infection in a patient with adult T-cell leukemia].
An adult T cell leukemia (ATL) accompanied with Isospora belli infection was described. A 65-year-old male was admitted to our hospital because of a two month history of watery diarrhea. On admission, physical examination showed slight pallor but no detectable superficial lymphadenopathies. Hepatosplenomegaly was not observed. Laboratory examination revealed a leukocyte count 5,500/microliters with 10% abnormal lymphoid cells. A majority of the abnormal lymphoid cells expressed both CD 4 and CD 8 antigens. The patient was diagnosed as chronic ATL, since anti-HTLV-1 antibody in his serum and monoclonal integration of HTLV-1 proviral DNA in his peripheral mononuclear cells were detected. Isospora belli was found in his feces thereafter, and trimethoprim/sulfamethoxazole was effective for diarrhea. In Japan, there have been only 9 reported cases of lymphoproliferative disorders (including five ATL patients) accompanied with Isospora belli infection. From the descriptions in those reports, these 9 cases might all be ATL patients.
Kawano
F
F
Department of Internal Medicine, Kumamoto National Hospital.
Nishida
K
K
Kurisaki
H
H
Tsukamoto
A
A
Satoh
M
M
Sanada
I
I
Shido
T
T
Obata
S
S
Kimura
K
K
Sasaki
Y
Y
D000368:Aged; D000818:Animals; D002908:Chronic Disease; D003048:Coccidiosis / Q000150:complications*; D003967:Diarrhea / Q000209:etiology; D006801:Humans; D007549:Isospora; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D008297:Male