Cord insulin and C-peptide--distribution in an unselected population.
OBJECTIVE
To assess the distribution of cord blood insulin in an unselected population, and examine its relation to birthweight centiles.


METHODS
District General Hospital in Nottinghamshire.


METHODS
209 unselected singleton births.


METHODS
Cord blood insulin; cord blood C-peptide; birthweight centiles.


RESULTS
Hyperinsulinaemic babies (greater than 97th centile for cord insulin) were found at all birthweight centiles. 15% of high birthweight babies were hyperinsulinaemic. For low birthweight babies, the distribution of cord insulin/C-peptide was skewed indicating a high number of low values. Hypoinsulinaemic babies were present up to the 50th centile for birthweight.


CONCLUSIONS
Abnormalities of fetal insulinisation may be found in babies of all birthweights.
Stanley
K P
KP
University Department of Obstetrics and Gynaecology, Northern General Hospital, Sheffield, UK.
Fraser
R B
RB
Milner
M
M
Bruce
C
C
D001724:Birth Weight; D002096:C-Peptide / Q000097:blood*; D005312:Fetal Blood; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood*; D015997:Neonatal Screening / Q000379:methods; D011863:Radioimmunoassay
D002096:C-Peptide; D007328:Insulin