Cardiomyopathy of copper deficiency: effect of vitamin E supplementation.
The present study was undertaken to determine whether the intraperitoneal injection of vitamin E to copper-(Cu) deficient rats fed fructose will protect the animals against the severity of Cu deficiency. Cu-deficient and adequate rats were fed a diet containing 62% carbohydrate as fructose. Half the Cu-deficient rats fed fructose were injected daily with vitamin E. Vitamin E treated rats were not protected against the lethal consequences of the interaction between Cu and fructose. These data provide evidence that the cardiomyopathy of Cu deficiency in rats consuming a fructose-based diet cannot be ameliorated by vitamin E supplementation.
Fields
M
M
Carbohydrate Nutrition Laboratory, Beltsville Human Nutrition Research Center, MD 20705.
Lewis
C G
CG
Lure
M D
MD
D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000209:etiology; D003300:Copper / Q000172:deficiency*; D005632:Fructose / Q000633:toxicity; D007501:Iron / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage*
D014810:Vitamin E; D005632:Fructose; D003300:Copper; D007501:Iron