Inversion of chromosome 16 and bone marrow eosinophilia in a myelomonocytic transformation of chronic myeloid leukemia.
We report a case of chronic myeloid leukemia (CML) in myelomonocytic transformation associated with bone marrow (BM) eosinophilia. At diagnosis, all BM cells showed a Ph chromosome. At the time of blastic phase, more than 50% of Ph+ cells had a pericentric inversion of chromosome 16, inv(16)(p13q22). This case confirms that blastic transformation of CML can involve any committed progenitor, and myelomonocytic leukemia with BM eosinophilia is specifically associated with rearrangement of chromosome 16 at band p13 and q22.
Asou
N
N
Second Department of Internal Medicine, Kumamoto University Medical School, Japan.
Sanada
I
I
Tanaka
K
K
Hidaka
M
M
Suzushima
H
H
Matsuzaki
H
H
Kawano
F
F
Takatsuki
K
K
D001752:Blast Crisis / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D004802:Eosinophilia / Q000150:complications* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome