title: Concurrent zidovudine-induced myopathy and hepatoxicity in patients treated for human immunodeficiency virus (HIV) infection.
abstract: Myopathy and hepatic toxicity are important complications of zidovudine (3'-azido-3'-deoxythymidine therapy) in patients infected with the human immunodeficiency virus (HIV) both may also occur in HIV infection in the absence of zidovudine therapy. We report 2 cases of myopathy caused by zidovudine, occurring within 16 wks of initiation of therapy, and a case of concurrent hepatic and muscle toxicity. In one case, electron microscopy demonstrated characteristic enlarged mitochondria with paracrystalline inclusions. This technique can distinguish the myopathies caused by either HIV or zidovudine. Both zidovudine-induced myopathy and hepatoxicity require discontinuation of the drug if severe.
authors.affiliation: Clinical Microbiology Unit, Westmead Hospital, NSW.
authors.forename: S C
authors.initials: SC
authors.lastname: Chen
authors.forename: S M
authors.initials: SM
authors.lastname: Barker
authors.forename: D H
authors.initials: DH
authors.lastname: Mitchell
authors.forename: S M
authors.initials: SM
authors.lastname: Stevens
authors.forename: P
authors.initials: P
authors.lastname: O'Neill
authors.forename: A L
authors.initials: AL
authors.lastname: Cunningham
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced*; D015215:Zidovudine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D015215:Zidovudine