Expression and localization of epidermal growth factor receptors and ras oncogene products in gynecologic tumors.
We have investigated the expression of the products of two well-characterized oncogenes, erbB and Ha-ras, in the primary cultures of human gynecologic tumor cells by indirect immunofluorescent analysis. Epidermal growth factor receptor (c-erbB gene product) and p21 (ras gene product) were highly expressed in 21 out of 26 cases (81%) and 14 out of 18 cases (78%), respectively. Furthermore, they were frequently co-localized in the same region of the cells. These results suggest that these two oncogene products may play a part in gynecologic tumorigenesis and that they can interact with each other.
Hiwasa
T
T
Division of Biochemistry, Chiba Cancer Center Research Institute, Japan.
Hirono
M
M
Suzuki
M
M
Tanaka
T
T
D016889:Endometrial Neoplasms / Q000737:chemistry / Q000235:genetics*; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015689:Oncogene Protein p21(ras) / Q000032:analysis*; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000235:genetics*; D012004:Rectal Neoplasms / Q000737:chemistry / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000235:genetics*
D066246:ErbB Receptors; D015689:Oncogene Protein p21(ras)