Familial Alzheimer's mutation: mRNA secondary structure revisited.
It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on comparison with other mammalian APP sequences does not support this possibility.
Brosius
J
J
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029.
Konings
D
D
D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D009690:Nucleic Acid Conformation; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics*
D016564:Amyloid beta-Protein Precursor; D012333:RNA, Messenger