Recurrent intra-cranial granulomata presenting as space-occupying lesions in a patient with common variable immunodeficiency.
A patient with profound panhypogammaglobulinaemia due to common variable immunodeficiency developed two discrete intra-cranial space-occupying lesions, 10 years apart, requiring craniotomy. Histological examination revealed the intra-cranial masses to be granulomata of unknown aetiology on both occasions.
Misbah
S A
SA
Department of Immunology, John Radcliffe Hospital, Oxford, UK.
Spickett
G P
GP
Esiri
M M
MM
Hughes
J T
JT
Matthews
W B
WB
Thompson
R A
RA
Chapel
H M
HM
D000293:Adolescent; D000361:Agammaglobulinemia / Q000150:complications*; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006099:Granuloma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D012008:Recurrence