A randomized trial of nimodipine in severe head injury: HIT I. British/Finnish Co-operative Head Injury Trial Group.
We studied the efficacy of nimodipine in severely head-injured patients in a randomized study. Of 176 patients who received nimodipine, 2 mg/h iv for 2 day, 53% had a favorable outcome (moderate or good recovery). Of 175 control patients, 49% had a favorable outcome. This difference was not statistically significant but does not exclude the possibility that a study of a larger number of patients could show a clinically useful benefit.
Teasdale
G
G
Department of Neurosurgery, Royal Victoria Hospital, Belfast.
Bailey
I
I
Bell
A
A
Gray
J
J
Gullan
R
R
Heiskanan
O
O
Marks
P V
PV
Marsh
H
H
Mendelow
D A
DA
Murray
G
G
D000328:Adult; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D009043:Motor Activity; D009553:Nimodipine / Q000627:therapeutic use*; D016896:Treatment Outcome
D009553:Nimodipine