Epithelial-mesenchymal interactions in experimental oral mucosal carcinogenesis: establishing a technique.
The carcinogen 4-nitroquinoline-1-oxide was applied to the palatal mucosa of rats for varying periods of time. This tissue was separated into epithelial and connective components and then recombined in various combinations and implanted into hypothymic mice. Seventy-two per cent of the implants were recovered and were suitable for detailed histological analysis. The technique provides a suitable model for the assessment of epithelial-connective tissue interactions in experimental oral mucosal carcinogenesis.
Rich
A M
AM
Section of Oral Medicine and Oral Surgery, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Victoria, Australia.
Reade
P C
PC
D015112:4-Nitroquinoline-1-oxide; D000818:Animals; D002450:Cell Communication; D003238:Connective Tissue / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D015112:4-Nitroquinoline-1-oxide