Lectin extracts of champedak seeds demonstrate selective stimulation of T lymphocyte proliferation.
The effect of extracts of champedak (Artocarpus integer) seed lectin on the proliferation of normal human lymphocyte was investigated. The IgA1 binding lectin was demonstrated to stimulate the proliferation of human peripheral blood mononuclear cells. Action of the lectin on enriched T and B cell populations demonstrated T lymphocyte specificity. The lectin was not mitogenic to B lymphocytes. Optimal stimulation of proliferative response was achieved when cells were subjected to 5 days exposure to the crude lectin at 20 micrograms/ml.
Hashim
O H
OH
Department of Biochemistry, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Gendeh
G S
GS
Jaafar
M I
MI
D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D007700:Kinetics; D037102:Lectins; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology; D037121:Plant Lectins; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D037102:Lectins; D008934:Mitogens; D037121:Plant Lectins; C043696:jacalin