title: Base-exchange and cell growth in 3T6 mouse fibroblasts.
abstract: Synthesis of phosphatidyl serine by base-exchange and DNA synthesis both declined rapidly in mouse fibroblast cultures upon withdrawal of serum from nutrient medium. Base-exchange returned to control levels within 3 h after the addition of serum, while DNA synthesis lagged by 10 h. Phosphatidyl serine synthesis is thus an early response of 3T6 cells to mitogenic signals.
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: U I
authors.initials: UI
authors.lastname: Richardson
authors.forename: R J
authors.initials: RJ
authors.lastname: Wurtman
mesh_terms: D000818:Animals; D001769:Blood; D002455:Cell Division; D002460:Cell Line / Q000378:metabolism; D003470:Culture Media / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis*; D051379:Mice; D019884:Nitrogenous Group Transferases; D010743:Phospholipids / Q000096:biosynthesis*; D012694:Serine / Q000378:metabolism*; D014166:Transferases / Q000378:metabolism*
chemical_list: D003470:Culture Media; D010743:Phospholipids; D012694:Serine; D004247:DNA; D014166:Transferases; D019884:Nitrogenous Group Transferases; C022370:phospholipid serine base exchange enzyme