[Cytological features of the development of multi-organ failure induced by exposure of the body to tumor necrosis factor].
Morphologic analysis of the changes in the internal organs after i.v. injection of 20 micrograms per mice of tumor necrosis factor (TNF) revealed the development of signs of multiorgan failure (interstitial and intraalveolar edema in the lung, acute fatty liver, tubular necrosis in kidney, brain edema) during first 24 h. The microvascular endothelial cells played a particular role in the state development. Results of investigation proved that endothelial cells were one of the major cellular targets for TNF action in vivo.
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D000818:Animals; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D008264:Macrophages / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D008833:Microcirculation / Q000502:physiology / Q000648:ultrastructure; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000473:pathology*; D009504:Neutrophils / Q000187:drug effects / Q000648:ultrastructure; D014409:Tumor Necrosis Factor-alpha / Q000633:toxicity*
D014409:Tumor Necrosis Factor-alpha
Tsitologicheskie osobennosti razvitiia poliorgannoĭ nedostatochnosti pri deĭstvii na organizm faktora nekroza opukholi.