Induction of carcinoma at ureterosigmoid anastomosis--with and without faecal stream.
The induction of tumours at the site of uretero-intestinal anastomosis was investigated in Hannover: WISTAR rats. The rats were divided into 3 groups. In one group (n = 70) the ureter of the left kidney was implanted into the colon, using microsurgical techniques developed for humans. In 13% of the rats in this group benign tumours developed; in 16% malignant tumours occurred. In a second group (n = 76) the ureter was implanted into a rectal bladder; the faeces were excluded from the anastomosis by a descending colon anus praeter. In this group benign tumours developed in 17% and malignant tumours in 8%, all of them being situated at the site of the anastomosis. In a control group (n = 80) no colonic tumour could be identified.
Miersch
W D
WD
Department of Urology, Bonn University, Germany.
Vogel
J
J
D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D012809:Colon, Sigmoid / Q000473:pathology / Q000601:surgery*; D008297:Male; D009366:Neoplasm Seeding; D011184:Postoperative Period; D051381:Rats; D011919:Rats, Inbred Strains; D012811:Sigmoid Neoplasms / Q000209:etiology* / Q000473:pathology; D014513:Ureter / Q000601:surgery*