title: Randomized, controlled trial of antibiotic therapy for Escherichia coli O157:H7 enteritis.
abstract: We undertook a prospective, controlled study to evaluate the effect of trimethoprim-sulfamethoxazole in children with proven Escherichia coli O157:H7 enteritis on the duration fo symptoms, on fecal excretion of pathogen, and on the risk of progression to hemolytic-uremic syndrome. There was no statistically significant effect of treatment on progression of symptoms, fecal pathogen excretion, or the incidence of HUS (2/22 vs 4/25; p = 0.67). Our results suggest that a multicentric trial using rapid diagnostic methods to permit early randomization should be carried out.
authors.affiliation: Department of Pediatrics, Sainte-Justine Hospital, Université de Montréal, Québec, Canada.
authors.forename: F
authors.initials: F
authors.lastname: Proulx
authors.forename: J P
authors.initials: JP
authors.lastname: Turgeon
authors.forename: G
authors.initials: G
authors.lastname: Delage
authors.forename: L
authors.initials: L
authors.lastname: Lafleur
authors.forename: L
authors.initials: L
authors.lastname: Chicoine
mesh_terms: D002648:Child; D002675:Child, Preschool; D004751:Enteritis / Q000188:drug therapy* / Q000382:microbiology; D004926:Escherichia coli / Q000145:classification / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000150:complications / Q000188:drug therapy*; D005243:Feces / Q000382:microbiology; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination