The role of propranolol and atropine in mitigating the toxic effects of scorpion venom on rat electrocardiogram.
The effects of the scorpion Leiurus quinquestriatus (H.&E.) venom on electrocardiogram (ECG) parameters such as P-R and Q-T intervals and R and T wave amplitudes were investigated in anesthetized rats. Venom was administered intramuscularly (i.m.) at three doses (100, 200 and 400 micrograms/kg). ECG limb lead II was recorded for 4-h sessions. Because autonomic nervous system tone plays an important role in influencing ECG findings, another study was completed with concomitant pharmacologic autonomic nervous system blockade. Propranolol or atropine was injected 20 min before venom administration in two groups of rats. The results indicated that the venom has drastic effects on the electrical activity of the heart. The Q-T interval developed a dose-response relationship after venom administration. Propranolol abolished the toxic effects of the venom on P-R and Q-T intervals as well as on R wave amplitude, while atropine had no effect on the ECG changes produced by the venom.
Omran
M A
MA
Pharmacology and Toxicology Department, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103-2714.
Abdel-Rahman
M S
MS
Nabil
Z I
ZI
D000818:Animals; D001285:Atropine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012604:Scorpion Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity
D012604:Scorpion Venoms; D001285:Atropine; D011433:Propranolol