title: Endocrine function in multiple sclerosis.
abstract: In 31 patients with multiple sclerosis (MS) the endocrine functions of the hypothalamus, the pituitary and several peripheral endocrine glands were assessed with a combined pituitary test; 3/31 patients had an endocrine disease: one primary hypothyroidism, one primary amenorrhea and one primary male hypogonadism. We found no patient with endocrine disease of the hypothalamus, the pituitary or the adrenals. However, the poststimulatory secretion of cortisol, growth hormone or thyroid-stimulating hormone was impaired in 7/31 patients, suggesting a possible preclinical endocrine insufficiency in these patients.
authors.affiliation: Neurology Clinic, Steglitz Clinic, Free University of Berlin, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Klapps
authors.forename: S
authors.initials: S
authors.lastname: Seyfert
authors.forename: T
authors.initials: T
authors.lastname: Fischer
authors.forename: W A
authors.initials: WA
authors.lastname: Scherbaum
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D002908:Chronic Disease; D004700:Endocrine System Diseases / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D013006:Growth Hormone / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000032:analysis / Q000627:therapeutic use*; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000503:physiopathology; D010049:Ovarian Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D010906:Pituitary Hormone-Releasing Hormones / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use*; D013733:Testicular Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
chemical_list: D001786:Blood Glucose; D010906:Pituitary Hormone-Releasing Hormones; D013006:Growth Hormone; D006854:Hydrocortisone