[In vitro formation of fibroblast colony-forming units in the bone marrow of patients with solid malignant tumors].
The number of bone marrow fibroblast colony-forming cells (CFU-F) were studied in twelve healthy donors, four colon (CP) and nine lung cancer patients (LP). A liquid culture system has been used to characterize human bone marrow CFU-F. The results showed any recognizable CFU-F in three patients with colon cancer and in two patients of the other group. One of the four CP and five of the nine LP presented a CFU-F value of 17 and 2, 8, 22, 29, 32, respectively compared to 65 from normal subjects. Two LP reached normal CFU-F values (normal range = 33-191). These data support the conclusion that the 84.6% of these solid tumor cancer patients study produced less number of proliferative status of fibroblast colony-forming cells.
Chasseing
A
A
Consejo Nacional de Investigaciones, Científicas y técnicas (CONICET), República Argentina.
Sánchez-Negrete
M G
MG
Fernández
O
O
Bordenave
H
H
Rumi
L S
LS
D001853:Bone Marrow / Q000473:pathology*; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology*; D003114:Colony-Forming Units Assay; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology*; D013234:Stem Cells / Q000473:pathology
Formación in-vitro de unidades formadoras de colonias fibroblásticas en medula ósea de pacientes con tumores sólidos malignos.