C-13 beta-acyloxymilbemycins, a new family of macrolides. Discovery, structural determination and biological properties.
A family of novel milbemycins possessing C-13 beta-acyloxy substitution was produced by Streptomyces hygroscopicus ATCC 53718. These compounds were detected by HPLC diode array analysis and possess anthelmintic and ectoparasiticidal activity. The origin of the oxygen atom at C-13 is discussed.
Haxell
M A
MA
Central Research Division, Pfizer Ltd., Sandwich, Kent, England.
Bishop
B F
BF
Bryce
P
P
Gration
K A
KA
Kara
H
H
Monday
R A
RA
Pacey
M S
MS
Perry
D A
DA
Kojima
Y
Y
Maeda
H
H
D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002107:Caenorhabditis / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; D013141:Spiro Compounds; C066128:VM 44864; C075540:UK 78624; C075539:UK 78629; C075541:UK 80694; C075542:UK 80695