title: The minimum effective dose of lignocaine to prevent injection pain due to propofol in children.
abstract: In a single-blind study of 100 children aged 1 to 10 years, the minimum effective dose of lignocaine required to prevent injection pain due to propofol was 0.2 mg.kg-1 when veins on the dorsum of the hand were used. This is more than twice the adult value. We concluded that injection pain should not limit the use of propofol in children if an adequate amount of lignocaine is mixed immediately prior to injection.
authors.affiliation: Department of Anaesthesia, Royal Hospital for Sick Children, Glasgow.
authors.forename: E
authors.initials: E
authors.lastname: Cameron
authors.forename: G
authors.initials: G
authors.lastname: Johnston
authors.forename: S
authors.initials: S
authors.lastname: Crofts
authors.forename: N S
authors.initials: NS
authors.lastname: Morton
mesh_terms: D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D000772:Anesthesia, Local; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007275:Injections, Intravenous / Q000009:adverse effects; D008012:Lidocaine / Q000008:administration & dosage*; D010146:Pain / Q000517:prevention & control*; D015742:Propofol / Q000009:adverse effects*; D016037:Single-Blind Method
chemical_list: D008012:Lidocaine; D015742:Propofol