Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism.
Localized cerebral utilization rates for glucose (CMRglu) were determined in 10 detoxified patients with alcoholic organic mental disorders and in 7 age-equivalent normal volunteers using [18F]2-fluoro-2-deoxyglucose positron emission tomography. Although gray and white matter CMRglu were not significantly different, normalized CMRglu was increased in the left cerebellar and parietal cortical regions and decreased in the right posterior white matter and anterior temporal regions of alcoholic patients, and the pattern of regional CMRglu differed between the two groups. The results suggest functional disruption of right-sided and frontal brain regions and hyperactivity of cerebellar-cortical connections in alcoholic chronic organic mental disorders.
Martin
P R
PR
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland.
Rio
D
D
Adinoff
B
B
Johnson
J L
JL
Bisserbe
J C
JC
Rawlings
R R
RR
Rohrbaugh
J W
JW
Stapleton
J M
JM
Eckardt
M J
MJ
D000368:Aged; D000425:Alcohol Amnestic Disorder / Q000000981:diagnostic imaging; D000437:Alcoholism / Q000000981:diagnostic imaging*; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D003704:Dementia / Q000000981:diagnostic imaging; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism; D004292:Dominance, Cerebral / Q000502:physiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed; D014899:Wernicke Encephalopathy / Q000000981:diagnostic imaging
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose