title: The efficacy of pre-operative controlled-release indomethacin in the treatment of post-operative pain.
abstract: A double-blind, placebo-controlled study in patients undergoing lumbar laminectomy was carried out to assess the morphine-sparing effect of a controlled-release indomethacin formulation ('Flexin Continus' tablets, 75 mg). Thirty patients were randomly allocated to receive 1 tablet of active or placebo study medication pre-operatively and their pain scores on visual analogue scale (VAS) and their morphine consumption, delivered by Patient Controlled Analgesia (PCA), were recorded over the 24-hour post-operative period. Over the first 4-hour post-operative period, the patients who had received active treatment reported less pain on VAS than those in the placebo group and this difference was statistically significant on recovery (p = 0.033) and at 1 hour post-recovery (p = 0.013). By 4, 8, 12 and 24-hours post-recovery the mean cumulative amount of morphine used by patients in the active treatment group was reduced by 25%, 23%, 37% and 30%, respectively, compared to the control group. At the 12-hour time point, the difference in morphine consumption approached statistical significance (p = 0.074). It is concluded that the pre-operative administration of controlled-release indomethacin reduces post-operative morphine requirements and significantly reduces VAS pain scores on recovery.
authors.affiliation: Department of Anaesthesia, Norfolk and Norwich Hospital, England.
authors.forename: W L
authors.initials: WL
authors.lastname: Rowe
authors.forename: A P
authors.initials: AP
authors.lastname: Goodwin
authors.forename: A J
authors.initials: AJ
authors.lastname: Miller
mesh_terms: D000328:Adult; D000368:Aged; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007796:Laminectomy / Q000009:adverse effects; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D003692:Delayed-Action Preparations; D009020:Morphine; D007213:Indomethacin