Evidence for involvement of nitric oxide in the non-adrenergic non-cholinergic (NANC) relaxation of human lower oesophageal sphincter muscle strips.
Electrical field stimulation of circular muscle strips from human lower oesophageal sphincter reveals a predominant relaxation response. This relaxation is non-adrenergic non-cholinergic (NANC). The nitric oxide synthesis-blocking agent N omega-nitro-L-arginine (10-100 microM) reduces or abolishes this NANC relaxation, suggesting involvement of nitric oxide in the response.
McKirdy
H C
HC
Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff.
McKirdy
M L
ML
Lewis
M J
MJ
Marshall
R W
RW
D000320:Adrenergic Fibers / Q000502:physiology*; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology*; D004943:Esophagogastric Junction / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D009126:Muscle Relaxation / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000494:pharmacology*; D019335:Nitroarginine
D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine