title: Determination of Zy 17617B in plasma by solid-phase extraction and liquid chromatography with automated pre-column exchange.
abstract: An automated chromatographic system, combining solid-phase extraction and automated pre-column exchange, is described for the routine determination of Zy 17617B at the pmol/ml level in human plasma. The sample extraction and elution onto the analytical column were performed automatically and concomitantly using a conventional liquid chromatographic apparatus equipped with a Merck OSP-2 on-line sample preparator. Validation data demonstrate the reliability of the method.
authors.affiliation: Zyma S.A., Department of Toxicology and Pharmacokinetics, Nyon, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Chollet
authors.forename: M
authors.initials: M
authors.lastname: Salanon
mesh_terms: D000930:Antidiarrheals / Q000097:blood*; D001562:Benzimidazoles / Q000097:blood*; D002853:Chromatography, Liquid; D006801:Humans; D015203:Reproducibility of Results; D013050:Spectrometry, Fluorescence
chemical_list: D000930:Antidiarrheals; D001562:Benzimidazoles; C052087:CGS 9343B