Effect of a benzodiazepine derivate Ro 15-4513 on ethanol-free selection and CNS mitochondrial energetics in rats.
1) Females are higher EtOH drinkers than males in E.F.S. experiments in rats. 2) Ro 15-4513 inhibited intake of EtOH. 3) Hypothalamus mitochondrial energetics, studied at Sites I and II, showed Ro 15-4513 inhibition of these parameters at different doses by sex: effects were seen in females at 15 mg and in males at 10 mg/kg rat/24 h. An uncoupled effect between electron transport and ADP/O was found.
Egaña
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E
Faculty of Medicine, Institute of Experimental Medicine, University of Chile, Santiago.
Salinas
A
A
Ramirez
M T
MT
D000428:Alcohol Drinking; D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004579:Electron Transport / Q000187:drug effects; D005260:Female; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics
D001386:Azides; D001569:Benzodiazepines; C042957:Ro 15-4513