D-factor and growth hormone enhance tumor necrosis factor-induced increase of Mn superoxide dismutase mRNA and oxygen tolerance.
D-Factor (differentiation-inducing factor or leukemia inhibitory factor) and growth hormone are proteins that regulate growth and differentiation of cells. In this study, we demonstrated that recombinant human D-factor and growth hormone caused a slight but significant protection of adult rats against oxygen toxicity without affecting levels of pulmonary manganous superoxide dismutase (MnSOD) mRNA. D-Factor and growth hormone also markedly enhanced tumor necrosis factor (TNF)-induced oxygen tolerance. This latter effect was associated with a marked enhancement of TNF-mediated induction of pulmonary MnSOD mRNA.
Tsan
M F
MF
Research Service, Samuel S. Stratton Department of Veterans Affairs Medical Center, Albany, New York.
White
J E
JE
Wong
G H
GH
D000818:Animals; D004357:Drug Synergism; D004361:Drug Tolerance / Q000235:genetics; D013006:Growth Hormone / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology*; D007327:Insufflation; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008168:Lung / Q000378:metabolism; D008222:Lymphokines / Q000494:pharmacology*; D010100:Oxygen / Q000633:toxicity*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000235:genetics*; D015996:Survival Rate; D014132:Trachea; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D013006:Growth Hormone; D013482:Superoxide Dismutase; D010100:Oxygen