title: Red cell enzyme and serum protein types in the Watut Anga of Papua New Guinea.
abstract: Historically, the Angan populations of Papua New Guinea have maintained a strong isolation and absorbed limited genes from their neighbours. This lack of intermixing is reflected in their relatively homogeneous cultural, linguistic and genetic profiles. We have determined the electrophoretic variation at 26 red cell enzyme, serum protein and haemoglobin loci in the Watut Anga, a splinter group occupying the Upper Watut Valley of Morobe Province. Their genetic profile reveals the lack of a number-of variants, such as PGM2*10 and MDH*3, known to exhibit high frequencies in other highland populations. The average heterozygosity in the Watut is also much lower when compared with other Papua New Guinean populations. Their present numerical strength notwithstanding, it appears that the Angan populations have experienced population bottlenecks in their evolutionary history which may have accentuated their genetic divergence from other Papua New Guinean populations.
authors.affiliation: PNG Institute of Medical Research, Goroka, Papua New Guinea.
authors.forename: K
authors.initials: K
authors.lastname: Bhatia
authors.forename: G
authors.initials: G
authors.lastname: Crane
authors.forename: N M
authors.initials: NM
authors.lastname: Blake
authors.forename: R L
authors.initials: RL
authors.lastname: Kirk
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D004912:Erythrocytes / Q000201:enzymology*; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D009512:New Guinea; D011110:Polymorphism, Genetic
chemical_list: D001798:Blood Proteins; D006680:HLA Antigens