Calcitonin gene-related peptide in the brain. Neurochemical and behavioral investigations.
CGRP in the amygdala is concentrated in an area close to the central nucleus. High potassium releases CGRP, and this release, as well as the tissue concentration of CGRP in the amygdala, can be influenced by neuroleptic drugs. Both molecular forms, alpha- and beta-CGRP, are present in the amygdala in a ratio of approximately 3:1. CGRP influences social behavior in chicken. Therefore, CGRP may have a prominent role in psycho-behavioral function and may be a target for action and/or side effects of antipsychotic drugs.
Saria
A
A
Department of Psychiatry, University Hospital, Innsbruck, Austria.
Bernatzky
G
G
Humpel
C
C
Haring
C
C
Skofitsch
G
G
Panksepp
J
J
D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D011188:Potassium / Q000494:pharmacology; D012919:Social Behavior; D013315:Stress, Psychological
D015740:Calcitonin Gene-Related Peptide; D011188:Potassium