title: Fractionated irradiation and early changes in noradrenaline induced potassium efflux (86Rb+) in rat parotid gland.
abstract: The effects of fractionated irradiation on the electrolyte fluid secretion from rat parotid gland were studied. Secretion was measured as noradrenaline stimulated potassium efflux in vitro with 86Rb+ as tracer for potassium. The irradiation was delivered either as a five-day schedule (total dose 20, 25, 30, 35, 40, 45 Gy) or a two-day schedule (total dose 24, 32 Gy). The noradrenaline stimulated efflux was decreased in comparison with contralateral controls 10 days after the last irradiation. The effect was dose-dependent. Based on the data available, alpha/beta ratio of the used system was calculated to about 20 Gy, which corresponds to other results regarding early radiation effects.
authors.affiliation: Department of Oncology, University Hospital, Umeå, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Franzén
authors.forename: S
authors.initials: S
authors.lastname: Sundström
authors.forename: M
authors.initials: M
authors.lastname: Karlsson
authors.forename: H
authors.initials: H
authors.lastname: Gustafsson
authors.forename: B
authors.initials: B
authors.lastname: Littbrand
authors.forename: R
authors.initials: R
authors.lastname: Henriksson
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D009638:Norepinephrine / Q000494:pharmacology; D010306:Parotid Gland / Q000378:metabolism / Q000528:radiation effects*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012414:Rubidium Radioisotopes
chemical_list: D012414:Rubidium Radioisotopes; D011188:Potassium; D009638:Norepinephrine