Sporeamicin A, a new macrolide antibiotic. I. Taxonomy, fermentation, isolation and characterization.
Sporeamicin A, a novel antibiotic, was isolated from the culture filtrate of an actinomycete. The producing organism, strain L53-18, was taxonomically assigned as a species of the genus Saccaropolyspora. The antibiotic was extracted with chloroform and was then purified by crystallization. It was obtained as colorless prisms from ethanolic solutions. Sporeamicin A exhibited a strong UV absorption peak at 276 nm. The molecular formula of sporeamicin A was determined to be C37H63NO12.
Yaginuma
S
S
Research Labolatories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
Morishita
A
A
Ishizawa
K
K
Murofushi
S
S
Hayashi
M
M
Mutoh
N
N
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D016930:Saccharopolyspora / Q000737:chemistry* / Q000145:classification
D000900:Anti-Bacterial Agents; C075534:sporeamicin A; D004917:Erythromycin