Prospective cerebral MR study of HIV seropositive and seronegative men: correlation of MR findings with neurologic, neuropsychologic, and cerebrospinal fluid analysis.
OBJECTIVE
As part of a longitudinal study of human immunodeficiency virus type 1 (HIV) infection, we attempted to identify early cerebral MR findings that might correlate to clinical evidence of central nervous system involvement.


METHODS
We studied 65 seropositive and 40 seronegative homosexual males using cranial MR, neurologic, immunologic, and neuropsychologic examinations.


RESULTS
The incidence of mildly enlarged ventricles, sulci, and punctate areas of abnormal signal in both groups was similar in both groups. Diffuse, poorly defined areas of abnormal white matter signal were difficult to consistently identify in seropositives. Enlarged adenoidal lymphoid tissue was found in 30 (46%) of seropositives and 2 (5%) of seronegatives (P = .0001). The incidence of sinus inflammatory change was similar in the two groups.


CONCLUSIONS
MR of intracranial contents is substantially normal in a non-AIDS HIV(+) population.
Cohen
W A
WA
Department of Radiology, University of Washington School of Medicine, Seattle.
Maravilla
K R
KR
Gerlach
R
R
Claypoole
K
K
Collier
A C
AC
Marra
C
C
Maxwell
C
C
Coombs
R W
RW
Longstreth
W T
WT
Townes
B D
BD
D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016655:HIV Core Protein p24 / Q000097:blood / Q000134:cerebrospinal fluid*; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies
D016655:HIV Core Protein p24