Netilmicin plus ceftriaxone versus amikacin plus ceftriaxone in the treatment of infections in granulocytopenic patients.
For the treatment of febrile episodes in granulocytopenic cancer patients, a combination of bactericidal and intravenously administered broad spectrum agents is recommended. An aminoglycoside plus a beta-lactame (piperacillin, azlocillin or IIIrd generation cephalosporins) are the drugs of first choice in an empiric approach. Because of frequent parenteral interventions (e.g. catheters, cannulations) in thrombopenic patients with multifactorial immunosuppression, we consider the application of once daily drugs, such as ceftriaxone, netilmicin or amikacin. For single dose treatment (1st day two applications), we used ceftriaxone in combination with netilmicin or amikacin as the first approach and retrospectively evaluated 47 patients for efficacy and safety.
Krcméry
V
V
Department of Clinical Oncology, Postgraduate Medical School, National Cancer Institute, Bratislava, Czechoslovakia.
Koza
I
I
Mardiak
J
J
Fuchsberger
P
P
Spánik
S
S
Trupl
J
J
Horníková
M
M
Kusenda
Z
Z
Sufliarsky
J
J
Svec
J
J
D000328:Adult; D000380:Agranulocytosis / Q000150:complications; D000583:Amikacin / Q000008:administration & dosage / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005334:Fever / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D009428:Netilmicin / Q000008:administration & dosage / Q000627:therapeutic use*; D012189:Retrospective Studies
D009428:Netilmicin; D002443:Ceftriaxone; D000583:Amikacin