title: Post-ischemic rupture of the anterior papillary muscle of the right ventricle associated with persistent pulmonary hypertension of the newborn: a case report.
abstract: We report the case of a six-day-old male infant exposed in utero to a prostaglandin synthetase inhibitor, who presented pulmonary arterial hypertension, tricuspid insufficiency, and electrocardiographic signs of diffuse myocardial ischemia. The necropsy showed organizing infarction of the anterior and posterior right papillary muscles (probably occurred in utero) with complete rupture of the former, besides abnormal muscularization of the intraacinar pulmonary arterioles (persistent fetal circulation of the newborn). The authors suggest a possible relation between the myocardial ischemic and pulmonary hypertensive lesions since the prostaglandin synthetase inhibitor can induce precocious pulmonary arteriolar muscularization and constriction of the arterial duct, leading to right ventricular overload, thus facilitating the occurrence of papillary and subendocardial ischemia.
authors.affiliation: Servico de Patologia, Instituto do Coracão-HCFMUSP, São Paulo, Brasil.
authors.forename: L A
authors.initials: LA
authors.lastname: Benvenuti
authors.forename: V D
authors.initials: VD
authors.lastname: Aiello
authors.forename: A J
authors.initials: AJ
authors.lastname: Cury
authors.forename: M
authors.initials: M
authors.lastname: Ebaid
mesh_terms: D003327:Coronary Disease / Q000150:complications*; D006341:Heart Rupture / Q000209:etiology* / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications*; D007231:Infant, Newborn; D008297:Male; D009336:Necrosis; D010210:Papillary Muscles / Q000473:pathology