title: Pasteurella multocida infection in total knee arthroplasty. Case report and literature review.
abstract: Pasteurella multocida, a small gram-negative bacterium, is part of the normal mouth flora of many animals, including domestic cats and dogs. While commonly associated with infections in animals, it is a rare cause of human disease. The majority of Pasteurella infections in humans occur with percutaneous inoculation of the organism following a bite by a cat or dog, although disease without antecedent animal exposure or with causal animal contact does occur. The spectrum of disease produced ranges from localized, including abscess, cellulitis, lymphadenopathy, and osteomyelitis, to systemic, with septicemia, septic arthritis, respiratory, and central nervous system involvement. Altered host defenses and underlying chronic disease, such as rheumatoid arthritis, corticosteroid therapy, and severe hepatic or renal disease, may predispose to more serious systemic manifestations of infection. The authors report a case of P. multocida infection in a total knee arthroplasty as a result of a dog scratch and review the literature reporting P. multocida infections in total knee arthroplasty.
authors.affiliation: Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY 10021.
authors.forename: T L
authors.initials: TL
authors.lastname: Guion
authors.forename: T P
authors.initials: TP
authors.lastname: Sculco
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000382:microbiology; D002415:Cats; D004285:Dogs; D005260:Female; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008875:Middle Aged; D010326:Pasteurella Infections / Q000382:microbiology*; D016979:Pasteurella multocida; D016459:Prosthesis-Related Infections / Q000382:microbiology* / Q000517:prevention & control; D011817:Rabbits