Influence of antiplatelet drugs on occlusion of arteriovenous fistula in uraemic patients.
A long-standing arteriovenous (A-V) fistula may develop thrombotic complications. In 20 patients on intermittent peritoneal dialysis (IPD) arteriovenous fistula was made surgically. We evaluated the efficacy of three antiplatelet drugs: Ibustrin (Group A), sulphinpyrazone (Group B) and alpha-tocopherol (Group C) in preventing thrombotic occlusion of A-V fistulas. Results of the trial indicate that the three drugs significantly reduce spontaneous platelet aggregation and ADP induced aggregation. The heparin neutralizing activity was significantly increased during treatment. Significant prolongation of bleeding time was observed only in Groups B and C. In patients receiving antiplatelet drugs no occlusion of A-V fistulas was observed. In the control group such complications occurred in 3 of the 20 patients. Our results indicate that antiplatelet drugs by inhibiting the platelet function may prevent thrombotic occlusions of A-V fistulas in IPD patients.
Janicki
K
K
Department of Surgery, School of Medicine, Lublin, Poland.
Dmoszyńska
A
A
Janicka
L
L
Stettner
S
S
Jesipowicz
J
J
D001166:Arteriovenous Shunt, Surgical; D005260:Female; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006801:Humans; D054833:Isoindoles; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010654:Phenylbutyrates / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013442:Sulfinpyrazone / Q000627:therapeutic use; D013927:Thrombosis / Q000517:prevention & control*; D014511:Uremia / Q000628:therapy*; D014810:Vitamin E / Q000627:therapeutic use
D054833:Isoindoles; D010654:Phenylbutyrates; D010975:Platelet Aggregation Inhibitors; D014810:Vitamin E; C020371:indobufen; D013442:Sulfinpyrazone