title: Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins.
abstract: Ras proteins play a critical role in controlling normal cellular growth and, when activated by mutation, in causing malignant transformation. Regulation of p21ras is achieved by GTPase activating proteins, which control the rate of hydrolysis of GTP to GDP, and also by GDP dissociation stimulators, which catalyze the exchange of guanine nucleotides. Several such proteins have now been identified and their control mechanisms characterized.
authors.affiliation: Imperial Cancer Research Fund, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Downward
mesh_terms: D000818:Animals; D020690:GTPase-Activating Proteins; D005786:Gene Expression Regulation; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D025542:Neurofibromin 1; D011506:Proteins / Q000502:physiology*; D016283:Proto-Oncogene Proteins p21(ras); D020703:ras GTPase-Activating Proteins
chemical_list: D020690:GTPase-Activating Proteins; D025542:Neurofibromin 1; D011506:Proteins; D020703:ras GTPase-Activating Proteins; D006153:Guanosine Diphosphate; D006160:Guanosine Triphosphate; D016283:Proto-Oncogene Proteins p21(ras)