Influence of the surface properties of low contact angle surfactants on the body distribution of 14C-poly(methyl methacrylate) nanoparticles.
The body distribution of surfactant-coated and non-coated poly(methyl methacrylate) nanoparticles with a size of 131 +/- 30 nm after intravenous injection into rats was investigated. The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35. These materials were preselected by the method of contact angle measurement. No overall valid relation between contact angles and the modification of body distribution could be found. However, the classification of surfactants by determination of the contact angles of the surfactant solution on the polymer material seems to be a very helpful method for preselection of poloxamers and poloxamines. Another parameter for preselection could be molecular weights of the poloxamines. Poloxamine 1508 was the most efficient coating material in reducing the liver uptake and increasing the blood levels of poly(methyl methacrylate) nanoparticles.
Tröster
S D
SD
Institute of Pharmaceutical Technology, J. W. Goethe-University, Frankfurt/Main, Germany.
Kreuter
J
J
D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008768:Methylmethacrylates / Q000493:pharmacokinetics*; D012157:Mononuclear Phagocyte System / Q000378:metabolism*; D000077423:Polidocanol; D011060:Poloxalene / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D013499:Surface Properties; D014018:Tissue Distribution
D008768:Methylmethacrylates; D000077423:Polidocanol; D011092:Polyethylene Glycols; D011060:Poloxalene