title: Cytogenetic evidence for a chromosome 22 tumor suppressor gene in ependymoma.
abstract: Although ependymomas comprise 5-10% of pediatric brain tumors, consistent cytogenetic aberrations have not been identified in these neoplasms. We report karyotypes for two ependymomas. A predominantly well-differentiated ependymoma contained several numerical chromosome aberrations, including monosomy 22. In contrast, an anaplastic ependymoma had a more complex karyotype that included loss of one chromosome 22 homologue and a balanced translocation at q13.3 in the remaining 22 homologue. These findings suggest the location of an ependymoma tumor suppressor gene on the long arm of chromosome 22.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: S
authors.initials: S
authors.lastname: Weremowicz
authors.forename: W J
authors.initials: WJ
authors.lastname: Kupsky
authors.forename: C C
authors.initials: CC
authors.lastname: Morton
authors.forename: J A
authors.initials: JA
authors.lastname: Fletcher
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics*; D002551:Cerebral Ventricle Neoplasms / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002892:Chromosomes, Human, Pair 22; D004806:Ependymoma / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D008297:Male; D009006:Monosomy; D014178:Translocation, Genetic / Q000235:genetics*