[Elimination kinetics of several clinically relevant enzymes in the blood plasma of cattle after intravenous bolus infusion of homologous preparations].
Extracts of homologous organs (liver, muscle) and of colostrum were infused intravenously in cattle of two different age groups: heifers (n = 9, each preparation was infused in 3 animals) and calves (n = 6, preparations from liver and muscle were infused in 3 animals each). Parameters of elimination kinetics were determined for some clinically relevant enzymes. Enzyme elimination was quicker in the younger animals. The volume of enzyme distribution was comparable to plasma volume. Biological half-lives in calves and heifers respectively were: CK from muscle 3.46 +/- 0.65 h and 8.27 +/- 3.27 h, AST from muscle 9.74 +/- 1.38 h and 33.48 +/- 3.74 h, AST from liver 14.99 +/- 0.81 h and 16.71 +/- 0.58 h, GLDH from liver 14.61 +/- 1.88 h and 25.09 +/- 4.13 h, SDH from liver 13.95 +/- 2.25 h and 17.68 +/- 0.81 h, GGT from colostrum 1.69 +/- 0.95 h (only heifers).
Schumacher
M
M
Klinik für Rinderkrankheiten, Tierärztlichen Hochschule Hannover.
Klee
W
W
Bickhardt
K
K
D000818:Animals; D002417:Cattle / Q000097:blood*; D003126:Colostrum / Q000201:enzymology*; D004798:Enzymes / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D008110:Liver Extracts / Q000493:pharmacokinetics*; D008297:Male; D009132:Muscles / Q000201:enzymology*; D014018:Tissue Distribution
D004798:Enzymes; D008110:Liver Extracts
Eliminationskinetiken einiger klinisch relevanter Enzyme im Blutplasma von Rindern nach intravenöser Bolus-infusion homologer Präparate.