Human immunodeficiency virus DNA copies as a virologic marker in a clinical trial with beta-interferon.
The number of human immunodeficiency virus (HIV) DNA copies in peripheral blood mononuclear cells (PBMC) was quantitated by the polymerase chain reaction (PCR) and used as a virologic marker in a clinical trial with beta-interferon (beta-IFN) (6 x 10(6) IU/day administered intravenously for 4 weeks). In 11 HIV-infected patients who were clinically stable, the number ranged from 10 to 1,063 copies per 10(5) PBMC. However, percent change of the number in the individual untreated patients stayed between -46.2% and 203.0% of the basal level by one month interval. In six patients who were treated with beta-IFN, changes in the number were not significant before and after the trial.
Oka
S
S
Department of Infectious Diseases, University of Tokyo, Japan.
Urayama
K
K
Hirabayashi
Y
Y
Kimura
S
S
Mitamura
K
K
Shimada
K
K
D015415:Biomarkers; D004279:DNA, Viral / Q000032:analysis / Q000096:biosynthesis*; D006678:HIV / Q000235:genetics* / Q000302:isolation & purification; D015658:HIV Infections / Q000235:genetics* / Q000382:microbiology / Q000628:therapy; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D016133:Polymerase Chain Reaction
D015415:Biomarkers; D004279:DNA, Viral; D016899:Interferon-beta