title: The gene lin-3 encodes an inductive signal for vulval development in C. elegans.
abstract: The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-alpha and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.
authors.affiliation: Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125.
authors.forename: R J
authors.initials: RJ
authors.lastname: Hill
authors.forename: P W
authors.initials: PW
authors.lastname: Sternberg
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence; D002107:Caenorhabditis / Q000196:embryology* / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins; D003001:Cloning, Molecular; D012734:Disorders of Sex Development; D004627:Embryonic Induction / Q000235:genetics*; D004815:Epidermal Growth Factor / Q000235:genetics; D005260:Female; D015801:Helminth Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D011993:Recombinant Fusion Proteins; D013234:Stem Cells / Q000502:physiology; D014844:Vulva / Q000196:embryology
chemical_list: D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D011993:Recombinant Fusion Proteins; C075912:Lin-3 protein, C elegans; D004815:Epidermal Growth Factor