Cyclophilin of Schistosoma japonicum.
A 623-bp cDNA molecule encoding cyclophilin, a specific cyclosporin A-binding protein, has been isolated from Schistosoma japonicum using a heterologous cDNA probe from Echinococcus granulosus. The nucleotide sequence of this molecule has been determined, and the deduced amino acid sequence has revealed extensive homology with homologues of other species. Southern blot analysis suggests that S. japonicum cyclophilin is the product of a single-copy gene. The cloning of this cDNA will allow an investigation of cyclophilin as a possible target of the antischistosome effects of cyclosporin A.
Argaet
V P
VP
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Mitchell
G F
GF
D000591:Amino Acid Isomerases / Q000737:chemistry* / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D004247:DNA / Q000737:chemistry*; D015342:DNA Probes; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D019696:Peptidylprolyl Isomerase; D014176:Protein Biosynthesis; D012549:Schistosoma japonicum / Q000737:chemistry* / Q000235:genetics
D002352:Carrier Proteins; D003062:Codon; D015342:DNA Probes; D004247:DNA; D000591:Amino Acid Isomerases; D019696:Peptidylprolyl Isomerase