Monitoring of laboratory parameters during carbamazepine therapy in psychiatric patients.
In recent years, carbamazepine has increasingly also been used in psychiatric indications. However, the manifold action of this drug also manifests itself in a number of adverse effects. In a prospective study including 46 patients, who were given carbamazepine for psychiatric indications and most of whom were also treated with one or several other psychotropic drugs, the following laboratory parameters were determined at two-weekly intervals: red and white blood count, platelets, SGOT, SGPT, gamma GT, alkaline phosphatase, serum calcium, serum sodium, IgA, IgG, IgM. Statistically significant changes were found in erythrocytes, leucocytes, platelets (decrease), Gamma GT (increase), serum calcium (decrease), IgA, IgM (decrease). The clinical relevance of these changes is discussed.
Sommer
R
R
Institute of Medical and Chemical Laboratory Diagnostics, Wagner-Jauregg Krankenhaus, Upper Austria, Linz.
Rittmannsberger
H
H
Stöbich
E
E
Kainz
C
C
Leblhuber
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D016903:Drug Monitoring; D004573:Electrolytes / Q000097:blood; D004798:Enzymes / Q000097:blood; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000188:drug therapy; D008875:Middle Aged
D004573:Electrolytes; D004798:Enzymes; D007136:Immunoglobulins; D002220:Carbamazepine