Effects of 2-deoxy-D-glucose on food intake of rats are affected by diet composition.
The effect of various doses of 2-deoxy-D-glucose (2-DG) on food intake in rats fed either a medium fat diet with a moderate carbohydrate content (MF-rats) or a carbohydrate-free high fat diet (HF-rats) was tested. Injections were given intraperitoneally either in the middle of the bright phase or 1 h after onset of the dark phase. During the light phase 2-DG induced a transient hyperphagia in both HF- and MF-rats, but the hyperphagia was somewhat less pronounced in HF-rats. During the dark phase 2-DG produced a hyperphagia in the MF-rats and a long-term hypophagia in the HF-rats. Since 2-DG elicited feeding in HF-rats during the light phase, the feeding response to 2-DG not only reflects hunger for carbohydrate as previously suggested but also seems to produce hunger for energy.
Delprete
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Institute of Veterinary Physiology, University of Zürich, Switzerland.
Scharrer
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D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects*; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012528:Satiety Response / Q000187:drug effects
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D003847:Deoxyglucose