title: [Germinoma with granulomatous reaction arising from the corona radiata; case report and review of articles].
abstract: We report a rare case of germinoma with granulomatous reaction arising from the corona radiata. This 20-year-old man was admitted to our hospital complaining of progressive motor weakness on the right side. CT demonstrated a poorly demarcated high density area in the left corona radiata, which was heterogeneously enhanced after administration of contrast medium. Moreover, the continuity of the mass to the ventricular wall was confirmed on MRI. At the first operation, subtotal removal of the tumor was performed through a fronto-parietal craniotomy. The diagnosis for the specific neoplasm was not established histologically, but granuloma caused by fungal infection was the most likely cause of the lesion. We tried amphotericin B (AmB), and remission of the tumor was obtained. However, during the following 3 months, the size of the tumor gradually enlarged again. AmB was repeatedly administered, but this time the treatment was ineffective. Six months later, on May 21, 1990, the second operation was performed and histological examination revealed typical germinoma consisting of two-cell pattern. Subsequently, the patient underwent focal irradiation of 33 Gy to the tumor site, and the tumor completely disappeared. As intracranial germinomas are observed to be successfully cured by radiotherapy and/or chemotherapy, choice of the therapeutic management must be carefully determined according to the histological diagnosis, especially in young people. A variety of locations of germinomas and the accompanying granulomatous reactions could create some diagnostic confusion, so great care must be taken in the treatment of much intracranial germinomas.
authors.affiliation: Department of Neurosurgery, Senboku National Hospital.
authors.forename: S
authors.initials: S
authors.lastname: Okuno
authors.forename: M
authors.initials: M
authors.lastname: Hisanaga
authors.forename: S
authors.initials: S
authors.lastname: Chitoku
authors.forename: T
authors.initials: T
authors.lastname: Sakaki
authors.forename: S
authors.initials: S
authors.lastname: Tsunoda
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D002540:Cerebral Cortex; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D004407:Dysgerminoma / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D000666:Amphotericin B