Increased histone H1(0) expression in differentiating mouse erythroleukemia cells is related to decreased cell proliferation.
The amount of histone H1(0) increases relative to other H1 subtypes in terminally differentiated cells, and its expression has been associated with the onset of differentiation. We have studied the kinetics of H1(0) accumulation in mouse erythroleukemia (MEL) cells and found that the levels of H1(0) reflect the rate of cell proliferation rather than the state of differentiation. This suggests that changes in the relative amount of H1(0) during MEL cell differentiation are primarily a consequence of cell cycle arrest.
Boix
J
J
Department of Biochemistry, School of Medicine and Cancer Research, University at L'Hôtel-Dieu de Québec, Canada.
Ruiz-Carrillo
A
A
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D006657:Histones / Q000096:biosynthesis*; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism*; D051379:Mice
D006657:Histones