Mouse neutrophils lack defensins.
Defensins are broad-spectrum antimicrobial peptides that are abundant in human, rat, and rabbit neutrophils. We now report that neutrophils from nine strains of mice lacked appreciable defensin content. Mice may therefore be imperfect experimental surrogates for humans or rats in models of infection in which neutrophil function is significant.
Eisenhauer
P B
PB
Department of Medicine, UCLA Center for the Health Sciences 90024-1678.
Lehrer
R I
RI
D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D023082:Defensins; D005260:Female; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D009504:Neutrophils / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains
D001798:Blood Proteins; D023082:Defensins