title: Preoperative chemotherapy for osteosarcoma with intravenous adriamycin and intra-arterial cis-platinum.
abstract: Ninety-seven patients with primary osteosarcoma of the extremities, all age 16 or older, were treated with adriamycin, 90 mg/m2, continuous i.v. infusion over 96 h, followed by cis-platinum, 120-160 mg/m2 by intra-arterial infusion. The first 37 patients, treated from 1979-1982, had a 59% complete response rate and a 54% 5-year continuous disease free survival (CDFS). Patients with complete response had an 85% 5-year CDFS compared with 13% for patients with partial and poor response. Patients treated between 1983-1988 with an intensified regimen have a 68% complete response rate and a 69% 3-year CDFS. Those who did not achieve complete remission were switched to an alternating chemotherapy program emphasizing the use of high-dose methotrexate. Limb salvage has been accomplished in 59% of patients in the first group and 80% in patients of the second group. Preoperative chemotherapy allows informed decisions to be made in postoperative management which can influence overall cure rates. Long-term follow-up is essential before final interpretation of the data.
authors.affiliation: UT MD Anderson Cancer Center, Department of Medical Oncology, Houston, Texas 77030.
authors.forename: R S
authors.initials: RS
authors.lastname: Benjamin
authors.forename: S P
authors.initials: SP
authors.lastname: Chawla
authors.forename: C H
authors.initials: CH
authors.lastname: Carrasco
authors.forename: A K
authors.initials: AK
authors.lastname: Raymond
authors.forename: J A
authors.initials: JA
authors.lastname: Murray
authors.forename: T
authors.initials: T
authors.lastname: Armen
authors.forename: S
authors.initials: S
authors.lastname: Patel
authors.forename: S
authors.initials: S
authors.lastname: Wallace
authors.forename: A
authors.initials: A
authors.lastname: Ayala
authors.forename: N E
authors.initials: NE
authors.lastname: Papadopoulos
mesh_terms: D001859:Bone Neoplasms / Q000188:drug therapy* / Q000401:mortality; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage*; D005121:Extremities; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy* / Q000401:mortality; D011300:Preoperative Care / Q000379:methods*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D004317:Doxorubicin; D002945:Cisplatin