title: Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity.
abstract: Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high-asthma strain (IMM/S 209) and one low-asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains - one high-asthma strain (IMM/S 740) and one low-asthma strain (IMM/R 201-16) - maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)3 the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete adjuvant (FCA).
authors.affiliation: Institute of Medical Microbiology, University of Copenhagen, Denmark.
authors.forename: M P
authors.initials: MP
authors.lastname: Winthereik
authors.forename: L
authors.initials: L
authors.lastname: Lundberg
authors.forename: J V
authors.initials: JV
authors.lastname: Spärck
authors.forename: T
authors.initials: T
authors.lastname: Katzenstein
authors.forename: D
authors.initials: D
authors.lastname: Sompolinsky
mesh_terms: D000375:Aging; D000536:Aluminum Hydroxide; D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D004198:Disease Susceptibility; D004802:Eosinophilia / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006168:Guinea Pigs / Q000235:genetics*; D007958:Leukocyte Count; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D013045:Species Specificity
chemical_list: D012965:Sodium Chloride; D000536:Aluminum Hydroxide; D010047:Ovalbumin