title: A case of malignant lymphoma accompanied by Klinefelter's syndrome.
abstract: A 66-year-old Japanese male with diffuse non-Hodgkin's lymphoma, of the pleomorphic type, complicated with Klinefelter's syndrome is reported. His phisique was characterized by a long arm span, disproportionately longer lower body dimensions and a small sized penis. He had no children. Chromosomal study revealed 47, XXY and hormonal quantification showed hypergonadtropic hypogonadism. Although chemotherapy was administered, his disease took a progressive course and he died. A discussion of chromosomal alteration and oncogenesis and review of the literature are included.
authors.affiliation: National Sengokuso Hospital, Kaizuka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Koyama
authors.forename: K
authors.initials: K
authors.lastname: Uejima
authors.forename: T
authors.initials: T
authors.lastname: Konishi
authors.forename: M
authors.initials: M
authors.lastname: Ishida
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Nishigaki
authors.forename: H
authors.initials: H
authors.lastname: Mizutani
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Kawase
authors.forename: T
authors.initials: T
authors.lastname: Tamaki
mesh_terms: D000368:Aged; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000235:genetics / Q000473:pathology; D008297:Male