Fluoxetine shortens circadian period for wheel running activity in mice.
Fluoxetine is a potent and specific serotonin re-uptake inhibitor and an effective antidepressant drug. Male mice were treated with either fluoxetine (8 mg/kg body weight per day) or saline. Wheel running activity was monitored for 2 weeks in a 12:12 LD cycle followed by 2 weeks in constant darkness (DD). Fluoxetine significantly shortened free-running circadian period for wheel running activity (23.93 +/- 0.08 h for fluoxetine treated mice versus 24.17 +/- 0.07 h for saline treated mice; p less than 0.03). These results are consistent with a role for serotonin in the regulation of circadian period in mice.
Possidente
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B
Biopsychology Program, Skidmore College, Saratoga Springs, NY 12866.
Lumia
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AR
McEldowney
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S
Rapp
M
M
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D012701:Serotonin / Q000502:physiology
D005473:Fluoxetine; D012701:Serotonin