title: Management of benign, giant gastric ulcers.
abstract: Giant gastric ulcers (greater than 3 cm in diameter) have traditionally been considered to be refractory to medical therapy and were commonly thought to initially appear as life-threatening hemorrhage requiring emergent operative therapy. This study was undertaken to evaluate the results of medical and surgical treatment of benign, giant gastric ulcers and the validity of these traditional teachings. A retrospective review of 44 patients with giant gastric ulcers was performed to evaluate the results of medical and surgical therapy at Hartford Hospital (Hartford, CT). The majority of these patients received medical therapy. Over 57 per cent received only medical therapy, while 25 per cent received primary, operative therapy. Contrary to popular belief, the authors found that patients who received initial medical therapy did not have high morbidity or mortality rates. Therefore, while the necessity of early surgical intervention following perforation or in patients with signs of hemorrhagic shock can not be refuted, the authors conclude that medical therapy of benign, giant gastric ulcers is often effective and not unduly hazardous. Giant gastric ulcers, in and of themselves, are not an indication for surgery.
authors.affiliation: Department of Surgery, Hartford Hospital, Connecticut.
authors.forename: J P
authors.initials: JP
authors.lastname: Welch
authors.forename: J G
authors.initials: JG
authors.lastname: Hammond
authors.forename: C W
authors.initials: CW
authors.lastname: Nissen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002985:Clinical Protocols / Q000592:standards; D003237:Connecticut / Q000453:epidemiology; D005743:Gastrectomy / Q000401:mortality / Q000592:standards*; D017052:Hospital Mortality; D006785:Hospitals, University; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D012008:Recurrence; D012086:Reoperation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000150:complications / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014628:Vagotomy / Q000401:mortality / Q000592:standards*; D014945:Wound Healing
chemical_list: D000897:Anti-Ulcer Agents