Stereoselective effect of phenprocoumon enantiomers on the binding of benzodiazepines to human serum albumin.
The effect of phenprocoumon enantiomers on the stereoselective binding of 3-substituted 1,4-benzodiazepines to human serum albumin (HSA) was studied by chromatography on HSA-Sepharose column. (S)-Phenprocoumon exerts stereoselective allosteric interaction on the binding of benzodiazepines. The structural requirements of enhanced stereoselectivities are similar to those found previously with (S)-warfarin.
Fitos
I
I
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
Simonyi
M
M
D001569:Benzodiazepines / Q000378:metabolism*; D002845:Chromatography; D006801:Humans; D007700:Kinetics; D010644:Phenprocoumon / Q000494:pharmacology*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D013237:Stereoisomerism; D014859:Warfarin / Q000494:pharmacology
D012709:Serum Albumin; D001569:Benzodiazepines; D014859:Warfarin; D010644:Phenprocoumon