title: Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.
abstract: The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).
authors.affiliation: Department of Clinical Genetics, Lund University Hospital, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Fioretos
authors.forename: S
authors.initials: S
authors.lastname: Heim
authors.forename: S
authors.initials: S
authors.lastname: Garwicz
authors.forename: J
authors.initials: J
authors.lastname: Ludvigsson
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002648:Child; D002874:Chromosome Mapping; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics; D051562:Proto-Oncogene Proteins c-bcr; D014178:Translocation, Genetic
chemical_list: D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr