title: [Analysis of the genetic predisposition to cancer in families of patients with multiple primary malignant neoplasms].
abstract: Clinical-genetic examination of 305 patients with multiple primary tumors aimed at determining the rate of genetic burden to their development and community of joint accumulation of tumors in families of these patients has revealed a significant genetic community of inheritance of breast cancer, carcinomas of colon, endometrium, ovaries and stomach in the families of patients with multiple primary tumors. Comparative analysis of genetic correlations has shown the greatest genetic burden in families of patients with multiple primary tumours as against the families of patients with solitary cancer.
authors.forename: R F
authors.initials: RF
authors.lastname: Gar'kavtseva
authors.forename: T P
authors.initials: TP
authors.lastname: Kazubskaia
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Sel'chuk
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics; D015984:Causality; D003110:Colonic Neoplasms / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics; D005260:Female; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics; D012307:Risk Factors
vernacular_title: Analiz geneticheskoĭ predraspolozhennosti k raku v sem'iakh bol'nykh pervichno mnozhestvennymi zlokachestvennymi novoobrazovaniiami.