title: The spectrum of clinical and pathological manifestations of AIDS in a consecutive series of autopsied patients in Mexico.
abstract: OBJECTIVE
  Little is known about the clinical profile of AIDS in Latin American populations. This study characterizes the clinical and pathological manifestations of AIDS in a representative series of Mexican AIDS patients at autopsy.
  
  
  METHODS
  The clinical and pathological findings were abstracted retrospectively for a sequential series of autopsied AIDS patients.
  
  
  METHODS
  Autopsies were conducted at the four major tertiary level hospitals that serve the majority of AIDS patients in Mexico City.
  
  
  METHODS
  Subjects included 177 consecutive patients diagnosed with AIDS between March 1984 and January 1989 who subsequently died and were autopsied in the same period in the study hospitals.
  
  
  METHODS
  Demographic characteristics, including age, gender, residence, socioeconomic status, and risk group; clinical presentation and autopsy findings, including opportunistic infections and malignancies.
  
  
  RESULTS
  Sixty per cent of the AIDS patients presented with wasting syndrome. The most common infections were cytomegalovirus (69%), tuberculosis (25%), and Pneumocystis carinii pneumonia (24%). Central nervous system infections were also common and included toxoplasmosis (19%) and cryptococcoses (10%). Kaposi's sarcoma was present in 30% of cases and non-Hodgkin's lymphoma in 9%.
  
  
  CONCLUSIONS
  Clinical manifestation, and types and frequency of opportunistic infections in our Mexican AIDS patients were more similar to those seen in AIDS patients in Africa and Haiti than in the United States and Europe. These findings suggest that the AIDS epidemic in Mexico has an 'intermediate' pattern and may be a prototype for Latin American countries.
authors.affiliation: Department of Epidemiology, Instituto Nacional de Cancerología, México.
authors.forename: A
authors.initials: A
authors.lastname: Mohar
authors.forename: J
authors.initials: J
authors.lastname: Romo
authors.forename: F
authors.initials: F
authors.lastname: Salido
authors.forename: J
authors.initials: J
authors.lastname: Jessurun
authors.forename: S
authors.initials: S
authors.lastname: Ponce de León
authors.forename: E
authors.initials: E
authors.lastname: Reyes
authors.forename: P
authors.initials: P
authors.lastname: Volkow
authors.forename: O
authors.initials: O
authors.lastname: Larraza
authors.forename: M A
authors.initials: MA
authors.lastname: Peredo
authors.forename: C
authors.initials: C
authors.lastname: Cano
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001344:Autopsy; D002648:Child; D002675:Child, Preschool; D003710:Demography; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000473:pathology