Resistance of Peptostreptococcus spp. to macrolides and lincosamides: inducible and constitutive phenotypes.
The activities of erythromycin and clindamycin against 350 Peptostreptococcus strains were studied during a 5-year period (1986 to 1991). In 5.1% of the Peptostreptococcus strains, which presented dissociated resistance (clindamycin MIC, less than or equal to 1 microgram/ml; erythromycin MIC, greater than 8 micrograms/ml), evidence of inducible macrolide-lincosamide resistance was shown. A total of 17.7% of the strains presented a constitutive phenotype; the clindamycin and erythromycin MICs for these strains were greater than 8 micrograms/ml.
Reig
M
M
Servicio de Microbiología, Hospital Ramón y Cajal, Instituto Nacional de la Salud, Madrid, Spain.
Moreno
A
A
Baquero
F
F
D002981:Clindamycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010462:Peptostreptococcus / Q000187:drug effects*; D010641:Phenotype
D002981:Clindamycin; D004917:Erythromycin