title: Lipid, lipoprotein, and apolipoprotein assessment during an 8-wk very-low-calorie diet.
abstract: The influence of a very-low-calorie diet (VLCD) on lipid pattern is controversial. To evaluate the long-term effect of semistarvation on lipid patterns, a group of severely obese patients [aged 37 +/- 12 y, body mass index (BMI) 40.0 +/- 0.9] underwent a VLCD for 8 wk. Total cholesterol (TC), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C), triglycerides (TGs), apolipoproteins A1 (apo A1) and B (apo B) were analyzed every week. TC (6.07 +/- 0.23 vs 5.53 +/- 0.25 mmol/L, P less than 0.0008), HDL-C (mmol/L 1.26 +/- 0.06 vs 1.04 +/- 0.05 mmol/L, P less than 0.0001), TGs (1.46 +/- 0.19 vs 1.06 +/- 0.10 mmol/L, P less than 0.0008), and apo A1 (1.57 +/- 0.06 vs 1.32 +/- 0.06 g/L, P less than 0.0002) decreased, whereas LDL-C and apo B showed a biphasic behavior: they significantly fell during the first 3 wk, but during the last weeks returned to their initial values.
authors.affiliation: Istituto di Clinica Medica e Gastroenterologia, Università di Bologna, Ospedale S Orsola, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Parenti
authors.forename: A C
authors.initials: AC
authors.lastname: Babini
authors.forename: M E
authors.initials: ME
authors.lastname: Cecchetto
authors.forename: P
authors.initials: P
authors.lastname: Di Bartolo
authors.forename: A
authors.initials: A
authors.lastname: Luchi
authors.forename: B
authors.initials: B
authors.lastname: Saretta
authors.forename: G
authors.initials: G
authors.lastname: Sorrenti
authors.forename: R
authors.initials: R
authors.lastname: Motta
authors.forename: N
authors.initials: N
authors.lastname: Melchionda
authors.forename: L
authors.initials: L
authors.lastname: Barbara
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000032:analysis; D001053:Apolipoproteins / Q000032:analysis*; D001055:Apolipoproteins B / Q000032:analysis; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000178:diet therapy*; D014280:Triglycerides / Q000097:blood
chemical_list: D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol