True hermaphrodites: an experimental model in the mouse.
When the Y chromosome from the Mus musculus domesticus mouse strain is placed onto the C57BL/6J mouse background ovarian and testicular components develop in half of the XY progeny (B6.YDOM), providing an excellent model of true hermaphroditism. We examined the correlation between gonadal sex and development of the internal genital tract in the B6.YDOM mouse at puberty. Of 55 mice examined 20 had bilateral testes, 33 were true hermaphrodites and 2 had mixed gonadal dysgenesis. In all mice with bilateral testes male accessory sexual organs developed bilaterally. In the true hermaphrodites testes were found on either side but preferentially on the left side. When a male feature was present on the ipsilateral side of the ovary, the seminal vesicle was more frequently found than prostate or vas. Testicular mass was significantly different between the true hermaphrodites with and those without bilateral seminal vesicles. Similar difference was found in those with and without bilateral prostates. The serum testosterone level was not significantly different between these groups. We conclude that the testicular mass is a better discriminant than serum testosterone for the presence or absence of seminal vesicles and prostates at puberty.
Houle
A M
AM
Urology Research Laboratory, Royal Victoria Hospital, Montreal, Quebec, Canada.
Taketo
T
T
D000818:Animals; D004195:Disease Models, Animal; D012734:Disorders of Sex Development / Q000097:blood / Q000235:genetics / Q000473:pathology; D005835:Genitalia / Q000473:pathology; D008297:Male; D051379:Mice; D010641:Phenotype; D011467:Prostate / Q000473:pathology; D012669:Seminal Vesicles / Q000473:pathology; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood
D013739:Testosterone