[Effect of the antioxidant ionol on myocardial energy metabolism and the course of traumatic shock].
Energy metabolism was studied in experiments on rats with due regard for the individual features of the organism's reaction to trauma. The animals were divided into 2 subgroups according to the survival period during the experiment. Disorders of mitochondrial function were revealed in both subgroups, but they differed in degree according to the severity of the process. Preliminary injection of the antioxidant ionol prolonged the animals' survival and prevented disorders of mitochondrial function. The article discusses the possibility of preventing activation of free-radical oxidation of the membrane lipids and removal of their damaging effect on the mitochondria with ionol.
Shamkulashvili
G G
GG
Dumbadze
G G
GG
Papava
M V
MV
Sharvashidze
V G
VG
Meerson
F Z
FZ
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy*
D002084:Butylated Hydroxytoluene
Vliianie antioksidanta ionola na énergeticheskiĭ metabolizm miokarda i techenie travmaticheskogo shoka.