Endogenous luteinizing hormone surges following administration of human chorionic gonadotropin: further evidence for lack of loop feedback in humans.
The existence of inhibitory short- and ultrashort-loop feedback mechanisms for luteinizing hormone (LH), while documented in animals, has been questioned in humans. Since human chorionic gonadotropin (hCG) binds to LH receptors but can be distinguished from LH in immunoassays, it is possible to identify LH surges in the face of exogenously administered hCG. The present study demonstrates LH surges at midcycle in normal volunteers and in women undergoing controlled ovarian hyperstimulation, given hCG. This provides further evidence for lack of loop feedback control of LH secretion in humans.
Nader
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Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School, Houston 77030.
Berkowitz
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AS
D006063:Chorionic Gonadotropin / Q000493:pharmacokinetics / Q000494:pharmacology*; D005246:Feedback; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000378:metabolism*; D008597:Menstrual Cycle; D010062:Ovulation Induction; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000503:physiopathology; D011374:Progesterone / Q000097:blood; D012636:Secretory Rate / Q000187:drug effects; D013268:Stimulation, Chemical
D006063:Chorionic Gonadotropin; D011374:Progesterone; D007986:Luteinizing Hormone