title: [The molecular genetics of cystic fibrosis: the delta F508 allele in Mexican families].
abstract: We have initiated the screening of the delta F508 cystic fibrosis (CF) mutation in our country basing our study on the polymerase chain reaction technique. In a sample of 10 western and a northeastern Mexican families that have at least one CF affected child, we found a delta F508 frequency of 59.1% among CF chromosomes. This frequency is similar to those reported for Spain. Furthermore, we found a correlation between the delta F508 allele and pancreatic insufficiency. This paper points out the advantage of the polymerase chain reaction technology for the analysis of Mendelian disorders.
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México.
authors.forename: A
authors.initials: A
authors.lastname: Rojas-Martínez
authors.forename: R M
authors.initials: RM
authors.lastname: Vázquez-Alemán
authors.forename: S
authors.initials: S
authors.lastname: Gustincich
authors.forename: J M
authors.initials: JM
authors.lastname: Cantú
authors.forename: H A
authors.initials: HA
authors.lastname: Barrera-Saldaña
mesh_terms: D000483:Alleles; D003550:Cystic Fibrosis / Q000208:ethnology / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D006580:Genetic Carrier Screening; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008800:Mexico / Q000208:ethnology; D009154:Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction
vernacular_title: Genética molecular de la fibrosis quistica: el alelo delta F508 en familias mexicanas.