[Relationships between manufacturing parameters and pharmaceutical-technological requirements of biodegradable microparticles. 2. Preparation of injectable microparticles in biodegradable polyester].
Local anesthetics containing biodegradable polyester microparticles are prepared using a modified solvent-evaporation process and a spray drying technique. The preparation methods are compared critically. The modified solvent-evaporation process is preferred for the preparation of microparticles. Yields of 90% and microparticle size distributions can be influenced in a reproducible manner. Using the spray drying technique yields are only 60%. The product is characterized by a high portion of microparticles under 10 microns, which are responsible for the rapid release of cinchocain in 168 h as well.
Thoma
K
K
Institut für Pharmazie und Lebensmittelchemie, Ludwig-Maximillians-Universität, München.
Schlütermann
B
B
D000779:Anesthetics, Local; D001673:Biodegradation, Environmental; D002849:Chromatography, Gas; D004339:Drug Compounding; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical
D000779:Anesthetics, Local; D011091:Polyesters
Beziehungen zwischen Herstellungsparametern und pharmazeutisch-technologischen Anforderungen an biodegradierbare Mikropartikeln. 2. Mitteilung: Verarbeitung biodegradierbarer Polyester zu injizierbaren Mikropartikeln.