title: Effect of ibuprofen on the healing and remodeling of bone and articular cartilage in the rabbit temporomandibular joint.
abstract: The purpose of this study was to determine the effect of ibuprofen on the healing and remodeling of bone and cartilage in the temporomandibular joint of the rabbit. Forty-two rabbits were operated on to create a groove and a hole in the articular surface of both the right and left mandibular condyles. Following surgery, the animals were divided into three groups. Group A (12 rabbits) was used as a control and the animals did not receive any medication. Group B (15 rabbits) was given a daily dose of 17 mg/kg of ibuprofen. Group C (15 rabbits) was given a daily dose of 34 mg/kg of ibuprofen. All animals were killed after 4 weeks. The 84 condyles were examined clinically and histologically. Statistical analysis showed a highly significant difference in the healing of bone and cartilage between groups A and C (P less than .01) and a significant difference between groups A and B (P less than .05). The results of this study indicate that ibuprofen has an adverse effect on the healing of bone and cartilage in the temporomandibular joint of the rabbit.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Washington Hospital Center, Washington, DC 20010.
authors.forename: G
authors.initials: G
authors.lastname: Obeid
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D002358:Cartilage, Articular / Q000187:drug effects*; D016009:Chi-Square Distribution; D005260:Female; D007052:Ibuprofen / Q000009:adverse effects*; D011817:Rabbits; D013704:Temporomandibular Joint / Q000187:drug effects*; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D007052:Ibuprofen