[IGF-1 and phosphate homeostasis during growth].
Inorganic phosphate (Pi) is an essential determinant of cellular growth and replication. IGF-1, a growth hormone dependent factor, enhances at the kidney level both the tubular reabsorption of inorganic phosphate (Pi) and the production of 1,25-dihydroxyvitamin D3. Through these two renal actions IGF-1 increases the extracellular concentration of Pi. Consequently, the amount of Pi available for cellular growth and bone mineral deposition is maintained at a higher level as compared to the concentration prevailing during the adult life. Thus, IGF-1 appears to play a pivotal role in the control of Pi economy, particularly during growth.
Caverzasio
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J
Bonjour
J P
JP
D000818:Animals; D002117:Calcitriol / Q000378:metabolism; D006128:Growth; D006706:Homeostasis; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007668:Kidney / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates; D007334:Insulin-Like Growth Factor I; D002117:Calcitriol
IGF-1 et homéostase du phosphate pendant la croissance.