Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization.
Recombinant lambda phage DNA containing segments of human O6-methylguanine-DNA transferase gene was employed to localize this gene among the human chromosomes using non-radioactive in situ hybridization technique. This gene was found to be present at the telomeric end, 26q, of the long arm of the chromosome 10.
Natarajan
A T
AT
MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.
Vermeulen
S
S
Darroudi
F
F
Valentine
M B
MB
Brent
T P
TP
Mitra
S
S
Tano
K
K
D002874:Chromosome Mapping / Q000379:methods*; D002879:Chromosomes, Human, Pair 10; D004247:DNA / Q000235:genetics; D006801:Humans; D008780:Methyltransferases / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D019853:O(6)-Methylguanine-DNA Methyltransferase
D004247:DNA; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase