title: Changes in the approach to central nervous system tumors in childhood.
abstract: Current approaches to children with brain tumors are in a state of evolution. Currently, 50% of children with all types of brain tumors may be expected to survive 5 years. Therefore, the goals of neuro-oncology have broadened to include improved survival and improved quality of life. This article reviews changes in therapy that have altered survival as well as changes in therapy as a consequence of increasing recognition of complications and toxicity of treatment.
authors.affiliation: Department of Neurology, State University of New York, Buffalo School of Medicine, New York.
authors.forename: P K
authors.initials: PK
authors.lastname: Duffner
authors.forename: M E
authors.initials: ME
authors.lastname: Cohen
mesh_terms: D001921:Brain / Q000528:radiation effects*; D001927:Brain Diseases / Q000209:etiology*; D001932:Brain Neoplasms / Q000628:therapy*; D002648:Child; D005910:Glioma / Q000628:therapy*; D006801:Humans; D008527:Medulloblastoma / Q000628:therapy*; D008727:Methotrexate / Q000009:adverse effects*; D011832:Radiation Injuries
chemical_list: D008727:Methotrexate