Fractionated irradiation and early changes in noradrenaline induced potassium efflux (86Rb+) in rat parotid gland.
The effects of fractionated irradiation on the electrolyte fluid secretion from rat parotid gland were studied. Secretion was measured as noradrenaline stimulated potassium efflux in vitro with 86Rb+ as tracer for potassium. The irradiation was delivered either as a five-day schedule (total dose 20, 25, 30, 35, 40, 45 Gy) or a two-day schedule (total dose 24, 32 Gy). The noradrenaline stimulated efflux was decreased in comparison with contralateral controls 10 days after the last irradiation. The effect was dose-dependent. Based on the data available, alpha/beta ratio of the used system was calculated to about 20 Gy, which corresponds to other results regarding early radiation effects.
Franzén
L
L
Department of Oncology, University Hospital, Umeå, Sweden.
Sundström
S
S
Karlsson
M
M
Gustafsson
H
H
Littbrand
B
B
Henriksson
R
R
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D009638:Norepinephrine / Q000494:pharmacology; D010306:Parotid Gland / Q000378:metabolism / Q000528:radiation effects*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012414:Rubidium Radioisotopes
D012414:Rubidium Radioisotopes; D011188:Potassium; D009638:Norepinephrine