Adriamycin resistance is characterized by ultrastructural changes in human leukaemic K562 cells in vitro.
Ultrastructural changes associated with adriamycin (ADM) resistance have been investigated in the human K562 leukaemic cell line: sensitive K562 cells, a resistant subline cultured in the continuous presence of ADM and resistant cells without ADM Transmission electron microscopy (TEM) study revealed that K562-resistant cells displayed ultrastructural modifications of the cell surface, chromatin and nucleolus conformation. Alterations were not directly related to the presence of adriamycin as deprivated cells exhibited modificated characters through a slow progressive recovery phenomenon.
Bobichon
H
H
Laboratoire de Biologie et GIBSA, UFR Pharmacie, Reims, France.
Okiemi
M G
MG
Broglio
C
C
Ploton
D
D
Dufer
J
J
D000107:Acetylation; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D002843:Chromatin / Q000187:drug effects / Q000648:ultrastructure; D004317:Doxorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D013048:Specimen Handling; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure
D002843:Chromatin; D004317:Doxorubicin; D004492:Edetic Acid