title: Reduction of immunoreactivity of bovine serum albumin conjugated with polyethylene glycol(PEG) in relation to its esterase activity.
abstract: Bovine serum albumin was modified with activated PEG2, 2,4-bis[O-methoxypoly(ethylene glycol)]-6-chloro-s-triazine. The PEG-modified albumin, in which 15 out of the total 60 amino groups in the albumin molecule were coupled with activated PEG2, lost immunoreactivity towards anti-albumin serum and retained 63% of the esterase activity of native albumin.
authors.affiliation: Toin University of Yokohama, Materials Science and Technology, Yokohama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsushima
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kodera
authors.forename: Y
authors.initials: Y
authors.lastname: Inada
mesh_terms: D004950:Esterases / Q000378:metabolism*; D011092:Polyethylene Glycols; D011233:Precipitin Tests; D012710:Serum Albumin, Bovine / Q000276:immunology* / Q000378:metabolism
chemical_list: D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D004950:Esterases