[Abnormalities of autonomic nervous systems in intoxications, including alcohol and drugs].
Disorders in the autonomic nervous system occur frequently in cases with alcoholism or various intoxications. Drugs, especially those related to neurotransmitters may induce complicated symptoms in the sympathetic or parasympathetic nervous system. Some of these symptoms are accompanied by peripheral neuropathy. Intoxication, especially alcoholism is often are combined with a malnutrition, such as avitaminosis. Dysautonomic symptoms change successively; at an early stage, drugs or toxins stimulate sympathetic or parasympathetic receptors, while the same receptors are inhibited at a later stage when the concentration of the substances rises in the blood. Frequent stimulations of the same receptor may produce change in the sensitivity of receptors, decreased metabolism or addiction. These changes suggest that a different approach towards the acute and chronic autonomic disorders caused by intoxications is needed.
Nakamura
S
S
Third Department of Internal Medicine, Hiroshima University School of Medicine.
D000435:Alcoholic Intoxication / Q000150:complications / Q000503:physiopathology; D000437:Alcoholism / Q000150:complications* / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000209:etiology*; D006801:Humans; D011041:Poisoning / Q000150:complications* / Q000503:physiopathology