Genotype, uterine position, and testosterone sensitivity in older female mice.
CF-1 and CK (C57BL/6J x AKr) female mice that developed in utero between two males (2M), adjacent to one male (1M), or between two females (0M) were tested for their sensitivity to the aggression-promoting property of testosterone (T) beginning at 9 months of age. Comparisons between the strains showed that a higher proportion of CF-1 females fought in response to T and that the period of hormone exposure required to induce aggression also was shorter in this strain. Within each of the genotypes, there were no systematic differences in responsiveness to T related to contiguity to males during fetal development. While the results provide further evidence for genotype as a major influence on neural sensitivity to androgen, they do not support uterine position of females relative to males as a source of phenotypic variation in responsiveness.
Cologer-Clifford
A
A
Department of Psychology, Lehigh University, Bethlehem, PA 18015.
Simon
N G
NG
Jubilan
B M
BM
D000374:Aggression / Q000502:physiology*; D000375:Aging / Q000502:physiology*; D000378:Agonistic Behavior / Q000502:physiology; D000818:Animals; D005260:Female; D005838:Genotype; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011930:Reaction Time / Q000502:physiology; D012733:Sex Differentiation / Q000502:physiology*; D012741:Sexual Maturation / Q000502:physiology*; D013739:Testosterone / Q000502:physiology*
D013739:Testosterone