title: Fibronectin type III-like sequences and a new domain type in prokaryotic depolymerases with insoluble substrates.
abstract: Fibronectin type III-like sequences are present in many proteins from higher eukaryotes and are involved in protein-protein interactions, heparin binding and cell adhesion. A nine-member family of bacterial sequences is shown to be significantly homologous to the type III-like sequences. All the sequences are contained in secreted depolymerases acting on complex, energy-rich insoluble substrates, in which they apparently do not participate in catalysis or substrate-binding, their exact function remaining unclear. Furthermore, a new family of sequences, present in some cellulases, is presented.
authors.affiliation: Instituto de Microbiología Bioquímica, Facultad de Biología, CSIC/Universidad de Salamanca, Spain.
authors.forename: C K
authors.initials: CK
authors.lastname: Hansen
mesh_terms: D000192:Actinomycetales / Q000201:enzymology*; D000421:Alcaligenes / Q000201:enzymology*; D000595:Amino Acid Sequence; D001406:Bacillaceae / Q000201:enzymology*; D001665:Binding Sites; D005353:Fibronectins / Q000737:chemistry*; D006026:Glycoside Hydrolases / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D012984:Software
chemical_list: D005353:Fibronectins; D006026:Glycoside Hydrolases