title: [Prognostic value of local vascular infiltration in infiltrating transitional carcinoma of the bladder].
abstract: The present retrospective study analyzes the evolution and survival of 79 patients with bladder infiltrant transitional carcinoma (T2-T3), which were treated with radical cystectomy and bilateral ilio-obturating lymphadenectomy. Pre-operative radiotherapy (57/79) and neo-adjuvant chemotherapy (24/79) was used as supplementary therapy. The univariate analysis showed the relationship between tumour vascular infiltration (TVI) and presence of nodes micrometastasis (p = 0.002). The variables with greater forecast power in the multivariate analysis for survival were a decline in the post-radio and/or neo-adjuvant chemotherapy tumoral stage (p = 0.000) and TVI (p = 0.001). Survival decreased significantly in patients with TVI (p = 0.008), this finding denoting a worse prognosis than the presence of nodular micrometastasis (p = 0.01).
authors.affiliation: Departamento de Urología, Facultad de Medicina, Universidad de Navarra.
authors.forename: F
authors.initials: F
authors.lastname: de Castro
authors.forename: P
authors.initials: P
authors.lastname: Sánchez
authors.forename: C
authors.initials: C
authors.lastname: Robledo
authors.forename: D
authors.initials: D
authors.lastname: Rosell
authors.forename: L
authors.initials: L
authors.lastname: Agüera
authors.forename: W
authors.initials: W
authors.lastname: Isa
authors.forename: J E
authors.initials: JE
authors.lastname: Robles
authors.forename: J J
authors.initials: JJ
authors.lastname: Zudaire
authors.forename: J M
authors.initials: JM
authors.lastname: Berián
mesh_terms: D000206:Actuarial Analysis; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009360:Neoplastic Cells, Circulating; D011379:Prognosis; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy
vernacular_title: Valor pronóstico de la infiltración vascular local en el carcinoma transicional infiltrante de vejiga.