[Long-term results of radiotherapy in stage I.II glottic carcinoma].
From 1965 to 1987, 271 patients were treated. Two hundred and sixty-two were male, and 9 were female. Age ranged from 36 to 91 years with a median value of 62 years. According to the UICC classification in 1987, 149 were T1a, 56 were T1b, 66 were T2. T2 was divided into T2a (with normal cord mobility), and T2b (with impaired cord mobility). Forty-seven were T2a and 19 were T2b. Total dose ranged from 24 to 84 Gy, and 245 received 60 Gy or more. Daily dose was 2 Gy in 249, and 3 Gy in 22. Field size ranged from 10 to 117 cm2. All 271 patients were treated with 6-MV X-ray. Adjuvant chemotherapy was performed in 91 patients. Follow-up was complete in 269 of 271 patients (99%). Eighty-four patients died of intercurrent disease. Thirty out of 84 (36%) died of second malignancy. A 10-year overall survival rate in 271 patients was 64% and a 10-year cause-specific survival rate (CSSR) was 92%. Ten-year CSSR were 94% in T1a, 92% in T1b, 90% in T2a, and 80% in T2b. Five-year local control rates were 87%, 77%, 84%, and 68%, respectively. Five patients relapsed after 5 years. Ten-year local control rates were 85%, 74%, 80%, and 68%, respectively. There seemed to be no relationship between local control rates and total dose, field size, TDF, and use of chemotherapy. Daily doses of more than 3 Gy seemed to increase complication rates.(ABSTRACT TRUNCATED AT 250 WORDS)
Hiramatsu
H
H
Department of Radiology, School of Medicine, Keio University.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D015996:Survival Rate; D013997:Time Factors