title: Guided tissue regeneration combined with osseous grafting in suprabony periodontal lesions. An experimental study in the dog.
abstract: The purpose of the present investigation was to evaluate the use of bone grafts in combination with the GTR-procedure in reinstituting periodontal support around teeth with horizontal bone loss. Orthodontic elastic bands were placed around mandibular and maxillary premolars in 3 dogs in order to induce breakdown of the periodontal tissues. When the destruction had reached a level corresponding to approximately half the root length, the elastic bands were removed and the teeth were scaled. After a period with plaque control, mucoperiosteal flaps were elevated on the buccal and lingual aspects of the experimental teeth. The exposed root surfaces were curetted, and a notch was made at the level of the reduced bone crest. In randomly selected test quadrants, Kielbone mixed with fibrin sealant (Tisseel) was placed in the interproximal space and in the bifurcations. Both the buccal and lingual aspect of the test teeth were then covered by a teflon membrane (Zitex) and the raised tissue flaps sutured in a coronally displaced position. The contralateral teeth (controls) were treated the same way, except that fibrin sealant without Kielbone was applied in the bifurcations and the interproximal space prior to the placement of the membranes. The membranes were removed by a 2nd operation after 35 days. Clinically, various complications were observed during healing. The buccal and lingual flap margins consistently failed to join in the interproximal area, and increasing recession of the flap margins and exposure of the membranes, resulting in accumulation of bacterial deposits and food debris, occurred during the period the membranes were maintained.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Periodontology and Oral Gerontology, Royal Dental College, Aarhus, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Warrer
authors.forename: T
authors.initials: T
authors.lastname: Karring
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D004285:Dogs; D004848:Epithelium / Q000473:pathology; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005881:Gingiva / Q000473:pathology; D016557:Guided Tissue Regeneration, Periodontal; D008567:Membranes, Artificial; D010519:Periodontium / Q000601:surgery; D011138:Polytetrafluoroethylene; D013524:Surgical Flaps / Q000379:methods
chemical_list: D015718:Fibrin Tissue Adhesive; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene