Suppression by cyclosporin A of anti-GBM nephritis in rats.
The suppressive effect of cyclosporin A (CyA) on the development of glomerulonephritis was evaluated in rats with either original- or crescentic-type anti-glomerular basement membrane (GBM) nephritis. CyA (2.5, 10 or 20 mg/kg) was given p.o. daily to original-type anti-GBM nephritic rats for 10 days from the day after the injection of anti-GBM serum. The development of the nephritis was dose-dependently suppressed by CyA before the production of specific antibody against rabbit gamma-globulin (the heterologous phase). In addition, CyA suppressed glomerular infiltration of leukocyte subsets (leukocyte with common antigen, T cell, helper T cell, suppressor/cytotoxic T cell, macrophage/monocyte). CyA was given p.o. daily to crescentic-type anti-GBM nephritic rats for 10 days from the 10th day after the injection of anti-GBM serum. CyA-administration caused a distinct suppression of the deterioration of nephritis during the autologous phase. In addition, CyA markedly suppressed the antibody production. The above data indicate that CyA has a beneficial effect on anti-GBM nephritis, and the antinephritic action of this agent may be due to the inhibition of glomerular infiltration of leukocyte subsets as well as the suppression of the antibody production.
Nagamatsu
T
T
Department of Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Kojima
N
N
Kondo
N
N
Hattori
T
T
Kojima
R
R
Ito
M
M
Suzuki
Y
Y
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001485:Basement Membrane / Q000276:immunology; D002784:Cholesterol / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000494:pharmacology*; D005921:Glomerulonephritis / Q000276:immunology / Q000517:prevention & control*; D007165:Immunosuppression Therapy; D007678:Kidney Glomerulus / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D011507:Proteinuria / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D000888:Antibodies, Anti-Idiotypic; D016572:Cyclosporine; D002784:Cholesterol; D000118:Acetylglucosaminidase