title: Fumonisin mycotoxicosis in broilers: performance and pathology.
abstract: Fusarium moniliforme culture material containing fumonisin B1 at 300 mg/kg was incorporated into a broiler starter ration and fed ad libitum to 1-day-old broiler chicks for 2 weeks in two experiments. Clinical features of the disease produced included diarrhea, a 19% reduction in body weight, a 30% increase in relative liver weight, and a worsening of feed conversion by 20 points at 2 weeks of age. Histologically, chicks fed fumonisin had multifocal hepatic necrosis, biliary hyperplasia, muscle necrosis, intestinal goblet-cell hyperplasia, and rickets. Simultaneous feeding of 0.5% aluminosilicate had no effect on the clinical disease or lesions. The clinical disease and lesions induced mimicked those of a viral enteritis.
authors.affiliation: Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens 30605.
authors.forename: T P
authors.initials: TP
authors.lastname: Brown
authors.forename: G E
authors.initials: GE
authors.lastname: Rottinghaus
authors.forename: M E
authors.initials: ME
authors.lastname: Williams
mesh_terms: D000538:Aluminum Silicates / Q000494:pharmacology; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002060:Bursa of Fabricius / Q000254:growth & development; D002645:Chickens; D005516:Food Microbiology; D037341:Fumonisins; D005670:Fusarium / Q000378:metabolism*; D008099:Liver / Q000254:growth & development; D009183:Mycotoxins / Q000506:poisoning*; D009929:Organ Size; D011201:Poultry Diseases / Q000139:chemically induced*; D013154:Spleen / Q000254:growth & development
chemical_list: D000538:Aluminum Silicates; D037341:Fumonisins; D009183:Mycotoxins; C049037:aluminosilicate; C056933:fumonisin B1