title: Lack of effect of omeprazole, cimetidine, and ranitidine on the pharmacokinetics of ethanol in fasting male volunteers.
abstract: The effects of three gastric antisecretory drugs on the pharmacokinetics of ethanol have been studied in a randomized crossover experiment. Male medical students (n = 12) took ethanol 0.8 g/kg body weight at 08.00 h after an overnight fast. On seven successive days before drinking ethanol they were given omeprazole 20 mg, cimetidine 800 mg, ranitidine 300 mg, or no drug, with a period of at least 7 days between treatments. The peak blood ethanol concentration of 21.9 to 22.8 mmol.l-1 occurred at 64 to 70 min after the end of drinking. The rate of disappearance of ethanol from the blood ranged from 3.0 to 3.3 mmol.l-1.h-1 and the rate of removal from the whole body ranged from 8.0 to 8.5 g.h-1. The apparent volume of distribution of ethanol was almost the same for all four treatments: mean 0.68 l.kg-1, corresponding to a mean total body water of 44 l (59% body weight). Mean areas under the concentration-time profiles of ethanol ranged from 83 to 87 mmol.l-1.h for the four treatments. It is concluded that omeprazole, cimetidine and ranitidine do not alter the kinetics of a moderate dose of ethanol.
authors.affiliation: Department of Internal Medicine, University Hospital, Linköping, Sweden.
authors.forename: K A
authors.initials: KA
authors.lastname: Jönsson
authors.forename: A W
authors.initials: AW
authors.lastname: Jones
authors.forename: H
authors.initials: H
authors.lastname: Boström
authors.forename: T
authors.initials: T
authors.lastname: Andersson
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000097:blood / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D005215:Fasting / Q000378:metabolism; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000097:blood / Q000494:pharmacology*; D011899:Ranitidine / Q000097:blood / Q000494:pharmacology*
chemical_list: D000431:Ethanol; D002927:Cimetidine; D011899:Ranitidine; D009853:Omeprazole