Sweet's syndrome responding to cyclosporin.
We report a case of Sweet's syndrome which responded to treatment with cyclosporin 4 mg/kg/day. Cyclosporin is effective in the treatment of many dermatoses, and although the immunosuppressive effects of cyclosporin are mainly attributed to inhibition of T-lymphocyte proliferation, it has also been shown to affect the functions of both neutrophils and monocytes. Possible mechanisms of action of cyclosporin in Sweet's syndrome are discussed.
Bourke
J F
JF
Department of Dermatology, Leicester Royal Infirmary, U.K.
Berth-Jones
J
J
Graham-Brown
R A
RA
D000328:Adult; D001706:Biopsy; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D012867:Skin / Q000473:pathology; D016463:Sweet Syndrome / Q000188:drug therapy* / Q000473:pathology
D016572:Cyclosporine