[Cryptococcosis in AIDS patients: a study of 19 cases].
We discuss 19 cases of infection due to Cryptococcus neoformans diagnosed in 438 AIDS patients admitted to our center (4%). Fourteen of them showed meningitis confirmed by culture of C. neoformans in CSF. Clinical features were rather unspecific and disorders in CSF parameters were non striking. The diagnostic techniques performed with best results were culture of C. neoformans and antigen determination, especially in serum. Survival probability at one year was 75%. Treatment response was good. Treatment with fluocytosine did not seem to provide additional benefits versus amphotericin alone, neither in respect to clinical evolution nor regarding survival probability at one year. Fluconazole has shown effectiveness in maintenance therapy, being not be possible to evaluate it as an acute phase therapy because the low number of cases in which it was studied. It is advisable to follow a suppressive treatment, having found a 10% relapse rate in patients following therapy and a 50% in those who interrupted it.
Gazapo Carretero
E
E
Servicio de Enfermedades Infecciosas, Hospital de la Princesa, Madrid.
García Aguado
C
C
Adrados de Llano
M
M
Martínez Blanco
M L
ML
Verdejo Ortes
J
J
González Lahoz
J M
JM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D003453:Cryptococcosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage; D005437:Flucytosine / Q000008:administration & dosage; D015497:HIV-1; D006716:Homosexuality; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D015819:Substance Abuse, Intravenous / Q000150:complications
D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine
Criptococosis en pacientes con SIDA: estudio de 19 casos.