title: Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus.
abstract: Tyromycin A, a new inhibitor of leucine and cysteine aminopeptidases has been isolated from mycelial cultures of the basidiomycete Tyromyces lacteus (Fr.) Murr. Its structure was established as 1,16-bis-[4-methyl-2,5-dioxo-3-furyl]hexadecane (1) by spectral analysis and transformation into ester and imide derivatives.
authors.affiliation: Lehrbereich Biotechnologie, Universität Kaiserslautern, Federal Republic of Germany.
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: M
authors.initials: M
authors.lastname: Semar
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: M
authors.initials: M
authors.lastname: Bross
authors.forename: W
authors.initials: W
authors.lastname: Steglich
mesh_terms: D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D001487:Basidiomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D005663:Furans; C075407:tyromycin A; D000626:Aminopeptidases; C075408:cysteine aminopeptidase; D007931:Leucyl Aminopeptidase