Influence of a menhaden oil diet on cercarial penetration of Schistosoma mansoni.
The ability of a menhaden oil (MO) diet to influence cercarial penetration into mouse tail skin was evaluated. Male CD-1 mice 4-6 wk old (15.2 g average weight) were fed a 0, 10%, or 20% MO-supplemented diet for 2 wk. After this time mice were infected with either 65 +/- 3 or 145 +/- 3 [35S]methionine/cysteine-labeled cercariae for 1 hr by tail immersion. Twenty-four hours and 7 days later groups of mice were killed and their tail skin removed and autoradiographed. At 24 hr postinfection, mice fed a 20% MO diet had significantly higher cercarial penetration than controls and 10% MO diets (56% +/- 5.2 vs. 44% +/- 2.9, P = 0.02, 1-tailed t-test). After 7 days mice fed a 20% MO diet retained more radioactive foci than controls or 10% MO diets (21% +/- 2.0 vs. 15% +/- 1.3, P = 0.01, 1-tailed t-test).
Fusco
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University of Illinois College of Medicine, Department of Biomedical Sciences, Rockford 61107.
Weaver
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Salafsky
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Shibuya
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T
D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011897:Random Allocation; D012550:Schistosoma mansoni / Q000502:physiology*; D012555:Schistosomiasis mansoni / Q000178:diet therapy* / Q000517:prevention & control; D013623:Tail / Q000469:parasitology
D015525:Fatty Acids, Omega-3; D005395:Fish Oils; C033266:Menhaden oil