Ceramide composition of whole brain synaptosomal gangliosides from mice genetically bred for divergent ethanol sensitivities.
A comparison of the two major ceramide molecular species (d18:1-C18:0 and d20:1-C18:0) of synaptosomal gangliosides GM1, GD1a+GT1a, GD1b, GT1b, revealed a difference between the ceramide composition of ethanol-sensitive LS and ethanol-insensitive SS whole brain synaptosomal gangliosides. In all comparisons, the ratio of the two major molecular species, (d18:1-C18:0/d20:1-C18:0) was less for LS than for SS mice.
Ullman
M D
MD
Research Service/GRECC, ENRM Veterans Hospital, Bedford, MA 01730.
Ventura
R F
RF
Draski
L J
LJ
Deitrich
R A
RA
Baker
R C
RC
D000818:Animals; D001923:Brain Chemistry; D002518:Ceramides / Q000032:analysis*; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005732:Gangliosides / Q000032:analysis*; D051379:Mice; D013574:Synaptosomes / Q000737:chemistry*
D002518:Ceramides; D005732:Gangliosides; D000431:Ethanol