Ehrlich tumour cells: Ca(2+)-uptake modification by aluminium lactate.
Aluminium lactate provokes the same modification of 45Ca(2+)-uptake by Ehrlich ascites tumour cells as does ferric lactate. The increase of uptake is metal-complex concentration-dependent, and in contrast to ferric lactate, is only partially inhibited by albumin. Under the same experimental conditions, chromic lactate provoked no modification of that uptake. A plasma membrane rigidity increase provoked by coordination binding of aluminium to phospholipids is likely to be the main cause of Ca(2+)-uptake modification by aluminium lactate.
Anghileri
L J
LJ
Biophysics Laboratory, Faculty of Medicine, University of Nancy, France.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000493:pharmacokinetics*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D051379:Mice
D007773:Lactates; D019344:Lactic Acid; D002118:Calcium