Validation of a HPLC method for the determination of bendazac and its main metabolite 5-hydroxybendazac in human plasma.
The purpose of this study was to validate an analytical method for the determination of bendazac and its main metabolite 5-hydroxybendazac in human plasma. The results obtained indicate that the method is reproducible, accurate, precise, sensitive and specific for the measurement of bendazac and 5-hydroxybendazac in the human plasma. Therefore it can be considered suitable for experimental purposes, routine application for drug monitoring and regulatory requirements.
Catanese
B
B
Istituto Ricerca Francesco Angelini S.p.A., Rome, Italy.
Panei
M
M
Picollo
R
R
Martinelli
B
B
Ciarniello
M G
MG
Baravelli
S
S
D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007191:Indazoles / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet
D007191:Indazoles; C051605:5-hydroxybendazac; C000123:bendazac