[Isoniazid content of lungs in patients with pulmonary tuberculosis depending on the method of its administration as part of a comprehensive preoperative preparation].
Isoniazid concentration in the resected areas of a lung was studied in 47 patients with tuberculosis. It has been proved that galvanization of the chest against the background of intermittent intravenous chemotherapy allows to create a high concentration of the preparation in the damaged part of a lung situated at the interelectrode space. Isoniazid content in the wall of the caverna and paracavernous tissues in patients after the direct current influencing was (5.3 +/- 1.0) and (15.2 +/- 1.2) mukg/g. These indices were significantly higher than in patients, who sustained enteral, or intravenous drip administration of the preparation 3 times a week. Intravenous intermittent chemotherapy in combination with galvanization is indicated at the time of preoperative preparation of the patients.
Strelis
A K
AK
Blinov
V Iu
VIu
Gubina
N A
NA
D000284:Administration, Oral; D006801:Humans; D007262:Infusions, Intravenous; D007538:Isoniazid / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism* / Q000601:surgery; D011300:Preoperative Care / Q000379:methods*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery
D007538:Isoniazid
Soderzhanie izoniazida u bol'nykh tuberkulezom legkikh v zavisimosti ot sposoba ego vvedeniia v komplekse predoperatsionnoĭ podgotovki.