title: SCL gene in human tumors.
abstract: The SCL gene encodes a member of the helix-loop-helix (HLH) family of transcription factors and is reportedly involved in up to 25% of T-cell acute lymphoblastic leukemia (T-ALL). We have surveyed over 120 primary human tumors including melanomas, myeloid, and lymphoid leukemias, and other solid tumors without evidence of rearrangements involving SCL. These results are further supported by low level expression of SCL in these tumors (as assessed by a polymerase chain-reaction-based method). We conclude that rearrangement/translocation with subsequent activation of SCL occurs infrequently in myeloid leukemias and melanomas.
authors.affiliation: Walter and Eliza Hall Institute of Medical Research, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Rockman
authors.forename: C G
authors.initials: CG
authors.lastname: Begley
authors.forename: G
authors.initials: G
authors.lastname: Kannourakis
authors.forename: G J
authors.initials: GJ
authors.lastname: Mann
authors.forename: A N
authors.initials: AN
authors.lastname: Dobrovic
authors.forename: R F
authors.initials: RF
authors.lastname: Kefford
authors.forename: K
authors.initials: K
authors.lastname: McGrath
mesh_terms: D001483:Base Sequence; D051792:Basic Helix-Loop-Helix Proteins; D002051:Burkitt Lymphoma / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D015870:Gene Expression; D015321:Gene Rearrangement; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics; D008545:Melanoma / Q000235:genetics; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger / Q000235:genetics; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D009838:Oligodeoxyribonucleotides; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D000073942:T-Cell Acute Lymphocytic Leukemia Protein 1; D014157:Transcription Factors; C067143:TAL1 protein, human