Influence of prior information of drug toxicity on patient compliance.
Sixty patients with pulmonary tuberculosis, who had not received any chemotherapy in the past, were divided into two groups. All the patients were put on isoniazid, rifampicin and pyrazinamide for 8 weeks followed by isoniazid and rifampicin for another 18 weeks. Group A patients were informed of the likely occurrence of anorexia and/or vomiting but Group B patients were not. Routine and default retrieval home visits were given to ensure maximal drug compliance. Drug toxicity related early defaults were significantly less common in Group A patients (1 of 30) as compared to Group B (6 of 30).
Gupta
P R
PR
Hospital for Chest and Tuberculosis, SMS Medical College, Jaipur.
Gupta
M L
ML
Purohit
S D
SD
Sharma
T N
TN
Bhatnagar
M
M
D000328:Adult; D000855:Anorexia / Q000139:chemically induced; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance / Q000523:psychology*; D010352:Patient Dropouts; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
D000995:Antitubercular Agents