[Limited proteolysis of human albumin and immunoglobulin G by Legionella pneumophila metalloproteinase].
Metalloproteinase of Legionella pneumophila is the major extracellular proteinase of this bacterial species which splits human immunoglobulin G in the hinge region to form the (Fab')2 fragment. This fragment is relatively stable and undergoes further proteolysis at a slow rate. The c' fragment is unstable and is apparently split down to fragments CH2 and CH3. The metalloproteinase splits human serum albumin down to products having lower molecular masses. Another bacterial metalloproteinase, thermolysin, produces a similar effect, although at a slower rate.
Gul'nik
S V
SV
Feokharus
G
G
Lavrenova
G I
GI
Varchenko
N V
NV
Stepanov
V M
VM
D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D006868:Hydrolysis; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism*; D016952:Legionella pneumophila / Q000201:enzymology*; D008666:Metalloendopeptidases / Q000302:isolation & purification / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D013820:Thermolysin / Q000378:metabolism
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D012709:Serum Albumin; D008666:Metalloendopeptidases; D013820:Thermolysin
Ogranichennyĭ proteoliz al'bumina i immunoglobulina G cheloveka metalloproteinazoĭ Legionella pneumophila.