Plasma interleukin-6 levels in continuous ambulatory peritoneal dialysis and hemodialysis patients.
Plasma levels of interleukin-6 (IL-6), a cytokine known to be involved in lymphocyte activation and in inflammation, were studied in 10 normal volunteers, 21 continuous ambulatory peritoneal dialysis (CAPD) patients and 41 hemodialysis patients. Plasma IL-6 levels in hemodialysis patients were significantly higher than those in normal volunteers and CAPD patients (p less than 0.05). The means of plasma IL-6 concentrations before and after hemodialysis did not change significantly. While IL-6 in peritoneal dialysate was detectable in only 3 of the 21 CAPD patients without peritonitis, it was extremely high in 2 patients with bacterial peritonitis. IL-6 levels decreased as peritonitis subsided.
Nakahama
H
H
Department of Medicine, Kansai Rosai Hospital, Amagasaki, Japan.
Tanaka
Y
Y
Shirai
D
D
Miyazaki
M
M
Imai
N
N
Yokokawa
T
T
Okada
M
M
Kubori
S
S
D000328:Adult; D000368:Aged; D015314:Dialysis Solutions; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000097:blood / Q000209:etiology / Q000276:immunology; D006435:Renal Dialysis / Q000009:adverse effects*; D013203:Staphylococcal Infections / Q000097:blood / Q000209:etiology / Q000276:immunology
D015314:Dialysis Solutions; D015850:Interleukin-6