title: The ontogeny and cellular distribution of estrogen receptors in normal mouse mammary gland.
abstract: The appearance, epithelial and stromal cell distribution of estrogen receptors (ER) in normal mouse mammary gland were determined between 1 and 10 weeks of age using immunohistochemistry. The effect of ovariectomy and estrogen (E)-treatment on the distribution and concentration of ER-positive cells at various ages was also analyzed. These studies demonstrate that ER are present in both mammary epithelial and stromal cells before the mammary gland exhibits a proliferative response or increase in progesterone receptor concentration as a result of E-treatment. Furthermore, an analysis of E-treatment suggests that although ER are present at an early age, there may be additional factors that determine the nature and extent of E-responsiveness.
authors.affiliation: Physiology Department, Michigan State University, East Lansing 48824-1101.
authors.forename: S Z
authors.initials: SZ
authors.lastname: Haslam
authors.forename: K A
authors.initials: KA
authors.lastname: Nummy
mesh_terms: D000818:Animals; D004848:Epithelium / Q000737:chemistry; D004967:Estrogens / Q000502:physiology; D007150:Immunohistochemistry; D008321:Mammary Glands, Animal / Q000737:chemistry* / Q000254:growth & development; D051379:Mice; D008807:Mice, Inbred BALB C; D011960:Receptors, Estrogen / Q000032:analysis*
chemical_list: D004967:Estrogens; D011960:Receptors, Estrogen