title: Relationship between joint space width and subchondral sclerosis in the osteoarthritic hand: a quantitative microfocal radiographic study.
abstract: Measurement of joint space width and subchondral sclerosis from x 5 macroradiographic examination of 32 patients with osteoarthritis (OA) of the hand over an 18-month period showed that joint space loss was symmetrical in both hands. Its change showed that over a period of time narrowing progressed proximally from distal interphalangeal to proximal interphalangeal, metacarpalphalangeal and wrist joints. Sclerosis was greatest in those joints at which the largest forces were exerted across the hand in precision, power and pulp-pinch grip, respectively. Our findings suggest that constitutional factors determine the onset of cartilage changes in OA which in turn result in subchondral sclerosis, the extent of which is determined by the pattern of normal forces within the hand.
authors.affiliation: Division of Anatomy and Cell Biology, United Medical School, Guy's Hospital, (Guy's Campus), London, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Buckland-Wright
authors.forename: D G
authors.initials: DG
authors.lastname: MacFarlane
authors.forename: J A
authors.initials: JA
authors.lastname: Lynch
mesh_terms: D000368:Aged; D005260:Female; D006225:Hand; D006801:Humans; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000473:pathology*; D011859:Radiography; D012598:Sclerosis; D013223:Statistics as Topic; D014955:Wrist Joint / Q000473:pathology*