HLA antigens and recurrent acute otitis media.
The frequencies of a number of HLA antigens were investigated in 45 individuals with clinical recurrent acute otitis media (rAOM), defined as six or more episodes of AOM during a 12-month period, and were compared to those in a control group from the same district. HLA-A2 was found to occur in 80% of the rAOM group, as compared to 55.9% of controls (p less than 0.01). HLA-A3 antigen occurred in only 11.1% of the rAOM group in contrast to 27.5% of controls (p less than 0.05). Among 22 prospectively followed children without any AOM during their first 3 years of life, the frequencies of HLA-A2 and HLA-A3 antigens were comparable with those among controls.
Kalm
O
O
Department of Otorhinolaryngology, University Hospital, Lund, Sweden.
Johnson
U
U
Prellner
K
K
Ninn
K
K
D000208:Acute Disease; D002648:Child; D006680:HLA Antigens / Q000032:analysis*; D015789:HLA-A2 Antigen / Q000032:analysis; D015791:HLA-A3 Antigen / Q000032:analysis; D006801:Humans; D010033:Otitis Media / Q000276:immunology*; D011446:Prospective Studies; D012008:Recurrence; D012189:Retrospective Studies
D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen