Optimal electron-beam treatment planning for retinoblastoma using a new three-dimensional Monte Carlo-based treatment planning system.
Electron-beam treatment planning for retinoblastoma was investigated and an optimal treatment plan was devised for a particular case using a new three-dimensional Monte Carlo-based treatment planning system known to be capable of correctly predicting dose perturbations caused by body surface obliquities and tissue heterogeneities. Computed tomography (CT) data files were used to construct a three-dimensional eye phantom representing the anatomy of a child's orbit. Dose distributions in sagittal, transverse, and coronal planes were predicted with 1-mm resolution. Study of these distributions led to an optimal treatment plan consisting of an anterior-lateral pair, with the anterior field being a 10-MeV, 30-mm-diam circular field, centrally blocked by a 10-mm-diam lucite lens shield and the lateral field being a 16-MeV, 30 x 25-mm D-shaped field. The anterior field delivers a therapeutic dose to the ora serrata, but it underdoses the posterior retinal surface behind the lens shield; the lateral field provides the necessary boost dose to the posterior retinal surface. An equally weighted combination of the two fields produces a dose distribution in which the entire retinal surface receives a therapeutic dose, with less than 10% of that dose being delivered to the lens, brain, and the contralateral orbit.
al-Beteri
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Department of Radiological Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Raeside
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D004583:Electrons; D005134:Eye Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008953:Models, Anatomic; D009010:Monte Carlo Method; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012175:Retinoblastoma / Q000532:radiotherapy*