Neuropsychological and neurological manifestations of HIV-1 dementia in drug users.
The cognitive and motor deficits associated with human immunodeficiency virus-1 (HIV-1) infection have been studied using neurological examination and neuropsychological tests. However, drug users with HIV-1 infection generally have been excluded from such studies. Forty-four well-characterized drug users stratified by Centers for Disease Control staging were administered a standardized neurological examination and a battery of neuropsychological tests under single-blind conditions designed to minimize the acute effects of psychoactive substances. The results of the blind neurological examination were consistent with the previously ascertained clinical staging of HIV-1 infection. The pattern of neuropsychological deficits across HIV-1 states was similar to those found in cohorts of homosexual men.
Handelsman
L
L
Psychiatry Service, Veteran Affairs Medical Center, Bronx, New York 10468.
Aronson
M
M
Maurer
G
G
Wiener
J
J
Jacobson
J
J
Bernstein
D
D
Ness
R
R
Herman
S
S
Losonczy
M
M
Song
I S
IS
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D003042:Cocaine; D003430:Cross-Sectional Studies; D015497:HIV-1; D006556:Heroin Dependence / Q000150:complications / Q000523:psychology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D015819:Substance Abuse, Intravenous / Q000150:complications* / Q000523:psychology; D019966:Substance-Related Disorders / Q000150:complications / Q000523:psychology
D003042:Cocaine