title: Identification of new urinary metabolites of trimeprazine in rats by gas chromatography-mass spectrometry.
abstract: The metabolites of trimeprazine were identified in urine of rats by gas chromatography-mass spectrometry. After the oral administration of trimeprazine, the urinary metabolites were extracted with diethyl ether before or after hydrolysis with beta-glucuronidase. The identified metabolites were N-demethyltrimeprazine,3-hydroxytrimeprazine,N-demethyl-3-++ +hydroxytrimeprazine and trimeprazine sulphoxide.
authors.affiliation: Korea Institute of Science and Technology, Seoul, South Korea.
authors.forename: T J
authors.initials: TJ
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Park
authors.forename: H S
authors.initials: HS
authors.lastname: Shin
mesh_terms: D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014291:Trimeprazine / Q000652:urine*
chemical_list: D014291:Trimeprazine