Caf1R gene and its role in the regulation of capsule formation of Y. pestis.
A new transcription unit of the f1 gene cluster was found. The DNA sequencing revealed one long open reading frame. Deletion and frame shift mutation analyses have demonstrated the importance of a corresponding gene product for the F1 antigen biosynthesis. A homology of the deduced amino acid sequence with that of AraC family DNA-binding regulators was shown. A potential regulatory DNA region is discussed.
Karlyshev
A V
AV
Institute of Immunology, State Concern Biopreparation, Lyubuchany, Moscow Region, Russia.
Galyov
E E
EE
Abramov
V M
VM
Zav'yalov
V P
VP
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000235:genetics* / Q000378:metabolism; D016667:Bacterial Capsules / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D004269:DNA, Bacterial; D005798:Genes, Bacterial; D005809:Genes, Regulator; D008969:Molecular Sequence Data; D015183:Restriction Mapping; D016415:Sequence Alignment; D015010:Yersinia pestis / Q000235:genetics* / Q000378:metabolism
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial