Neuronal Ca2+ signalling takes the local route.
The past year has seen several sets of experimental results demonstrate that fast, large and highly localized rises in intracellular Ca2+ concentration can occur in neurons. These results confirm previous theoretical predictions of acute spatial compartmentalization of Ca2+ signalling, and document a form of signalling that may occur whenever rapid and local signal processing is the goal. The dimensions involved present severe challenges for attempts to directly measure these signalling events.
Augustine
G J
GJ
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710.
Neher
E
E
D000818:Animals; D002118:Calcium / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D002118:Calcium