title: C-13 beta-acyloxymilbemycins, a new family of macrolides. Discovery, structural determination and biological properties.
abstract: A family of novel milbemycins possessing C-13 beta-acyloxy substitution was produced by Streptomyces hygroscopicus ATCC 53718. These compounds were detected by HPLC diode array analysis and possess anthelmintic and ectoparasiticidal activity. The origin of the oxygen atom at C-13 is discussed.
authors.affiliation: Central Research Division, Pfizer Ltd., Sandwich, Kent, England.
authors.forename: M A
authors.initials: MA
authors.lastname: Haxell
authors.forename: B F
authors.initials: BF
authors.lastname: Bishop
authors.forename: P
authors.initials: P
authors.lastname: Bryce
authors.forename: K A
authors.initials: KA
authors.lastname: Gration
authors.forename: H
authors.initials: H
authors.lastname: Kara
authors.forename: R A
authors.initials: RA
authors.lastname: Monday
authors.forename: M S
authors.initials: MS
authors.lastname: Pacey
authors.forename: D A
authors.initials: DA
authors.lastname: Perry
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: H
authors.initials: H
authors.lastname: Maeda
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002107:Caenorhabditis / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D007783:Lactones; D018942:Macrolides; D013141:Spiro Compounds; C066128:VM 44864; C075540:UK 78624; C075539:UK 78629; C075541:UK 80694; C075542:UK 80695