title: Inhibition of Ca2+ uptake in freshwater carp, Cyprinus carpio, during short-term exposure to aluminum.
abstract: In carp exposed to pH 5.2 in fresh water, the Ca2+ influx from the water is reduced by 31% when compared to fish in water of neutral pH. At pH 5.2, the Ca2+ influx but not Na+ uptake is decreased by aluminum (Al). Al reduces Ca2+ influx dose-dependently: a maximum 55% reduction was observed after 1-2 h exposure to 200 micrograms.1(-1) (7.4 microM) Al. Branchial Ca2+ efflux is less sensitive to Al and affected only by exposure for more than 1 h to high Al concentrations. Na+ influx is not affected by concentrations Al up to 400 micrograms.1(-1). Na+ efflux, similarly to Ca2+ efflux, increased when fish were exposed for more than 1 h to 400 micrograms.1(-1) Al.
authors.affiliation: Department of Animal Physiology, Faculty of Science, University of Nijmegen, The Netherlands.
authors.forename: P M
authors.initials: PM
authors.lastname: Verbost
authors.forename: F P
authors.initials: FP
authors.lastname: Lafeber
authors.forename: F A
authors.initials: FA
authors.lastname: Spanings
authors.forename: E M
authors.initials: EM
authors.lastname: Aarden
authors.forename: S E
authors.initials: SE
authors.lastname: Wendelaar Bonga
mesh_terms: D000535:Aluminum / Q000097:blood / Q000633:toxicity*; D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002347:Carps / Q000378:metabolism*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012964:Sodium / Q000097:blood / Q000378:metabolism*; D012995:Solubility
chemical_list: D012964:Sodium; D000535:Aluminum; D002118:Calcium