Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major.
Cell-mediated, but not antibody-mediated, immune responses protect humans against certain pathogens that produce chronic diseases such as leishmaniasis. Effective vaccination against such pathogens must therefore produce an immunological "imprint" so that stable, cell-mediated immunity is induced in all individuals after natural infection. BALB/c mice "innately susceptible" to Leishmania major produce antibodies after substantial infection. In the present study, "susceptible" mice injected with a small number of parasites mounted a cell-mediated response and acquired resistance to a larger, normally pathogenic, challenge. This vaccination strategy may be applicable in diseases in which protection is dependent on cell-mediated immunity.
Bretscher
P A
PA
Department of Microbiology, University of Saskatchewan, Saskatoon, Canada.
Wei
G
G
Menon
J N
JN
Bielefeldt-Ohmann
H
H
D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D004198:Disease Susceptibility; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000032:analysis / Q000145:classification; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology
D000913:Antibodies, Protozoan; D007074:Immunoglobulin G