title: An EEG analysis of drug effects after mild head injury in mice.
abstract: An electroencephalographic (EEG) and behavioral model of head injury in unanesthetized, free moving mice has been used to test the effects of TRH and GM1. In our experimental conditions a mechanical head injury capable of inducing loss of righting reflex for 2 to 60 sec, also induces a consistent decrease of the total power of the spectrum of EEG and a decrease of the power of fast beta band (20-40 Hz) for at least 120 min. TRH, injected after trauma in dose of 10 mg/kg, caused improvement of EEG total power of the spectrum. GM1 in high (30 mg/kg) but not in low dose (5 mg/kg) caused more rapid restoration of both the total power and fast as well as slow beta band power. These results suggest that GM1 has favorable effects on post-concussive neurophysiological symptoms in head injured animals.
authors.affiliation: Istituto Superiore di Sanità, Roma, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Antal
authors.forename: A
authors.initials: A
authors.lastname: d'Amore
authors.forename: D
authors.initials: D
authors.lastname: Nerozzi
authors.forename: S
authors.initials: S
authors.lastname: Palazzesi
authors.forename: G
authors.initials: G
authors.lastname: Pezzini
authors.forename: A
authors.initials: A
authors.lastname: Loizzo
mesh_terms: D000818:Animals; D006259:Craniocerebral Trauma / Q000188:drug therapy / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography; D005677:G(M1) Ganglioside / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*
chemical_list: D005677:G(M1) Ganglioside; D013973:Thyrotropin-Releasing Hormone