title: [Choroid melanoma. A retrospective randomized comparative study of ruthenium irradiation vs enucleation].
abstract: A randomized retrospective study concerning survival of Ruthenium treatment and enucleation in melanoma patients has been performed. For 112 patients from Hamburg who underwent Ruthenium therapy individual match partners were selected in Copenhagen where during the same period of time enucleation was the standard procedure. Selection took place concerning patient's age and sex at the time of treatment, initial tumor volume and the time of treatment. The present status of the patients was not known during the selection process. During the observation time of 12 years there was a survival rate after irradiation of 77.9% and after enucleation of 78.6%. Cox' regression disclosed a coefficient of 0.049 with a standard aviation of 0.293 and a P-value of 0.867. All parameters were showing no statistical difference between Ruthenium treated and enucleated patients. The survival rate in males was 69.2%, female patients 87.2%. For male patients there was a 2,4-fold higher risk to develop metastasis compared with female patients. Patient's age at the time of treatment correlated significantly with the prognosis. There was an increase in mortality risk by factor 1.4 per decade.
authors.affiliation: Univ.-Augenklinik Hamburg.
authors.forename: R
authors.initials: R
authors.lastname: Guthoff
authors.forename: J
authors.initials: J
authors.lastname: Frischmuth
authors.forename: O A
authors.initials: OA
authors.lastname: Jensen
authors.forename: K
authors.initials: K
authors.lastname: Bjerrum
authors.forename: J U
authors.initials: JU
authors.lastname: Prause
mesh_terms: D000368:Aged; D001918:Brachytherapy; D002423:Cause of Death; D002830:Choroid Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D015353:Eye Enucleation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D008875:Middle Aged; D012429:Ruthenium Radioisotopes / Q000627:therapeutic use*; D015996:Survival Rate
chemical_list: D012429:Ruthenium Radioisotopes
vernacular_title: Das Aderhautmelanom. Eine retrospektive randomisierte Vergleichsstudie Ruthenium-Bestrahlung vs Enukleation.