Anti-IgG autoantibodies in HIV-infected hemophilia patients.
Sera of 76 HIV-negative hemophilia patients, 103 HIV-positive (HIV+) hemophilia patients free of AIDS or AIDS related complex (ARC), and 32 HIV+ hemophilia patients with AIDS/ARC were tested for four different anti-IgG activities. IgG-anti-F(ab')2 gamma, IgM-anti-F(ab')2 gamma, and IgG-anti-Fc gamma serum activities were significantly associated with the clinical stage of HIV infection, whereas IgM-anti-Fc gamma was not. IgG-anti-F(ab')2 gamma activity was found to be caused by cross-reaction of anti-HIV antibody with an epitope within the constant CH1 domain of human IgG. HIV+ hemophilia patients with severe thrombocytopenia (less than 50,000/microliters platelet counts) had significantly higher IgM-anti-IgG activity than patients with greater than 50,000/microliters platelets. Because anti-IgG antibodies possess immunoregulatory properties, our results may serve as a possible explanation for the frequent B cell disorders encountered in HIV-infected patients.
Süsal
C
C
Department of Transplantation Immunology, University of Heidelberg, FRG.
Lewin
I V
IV
Stanworth
D R
DR
Terness
P
P
Daniel
V
V
Oberg
H H
HH
Huth-Kühne
A
A
Zimmermann
R
R
Opelz
G
G
D000386:AIDS-Related Complex / Q000097:blood / Q000150:complications / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology; D000361:Agammaglobulinemia / Q000209:etiology / Q000276:immunology; D000595:Amino Acid Sequence; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D003429:Cross Reactions; D005803:Genes, Immunoglobulin; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D015699:HIV Envelope Protein gp120; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M