Hypogastrinemia and esophageal atresia.
To investigate extraesophageal anomalies in infants with esophageal atresia, preoperative plasma gastrin was measured in 12 infants. The median plasma gastrin was 32 ng/L (interquartile range, 24 to 44). There was significant correlation with birth weight (rs = .73, P less than .05) and gestational age (rs = .74, P less than .05). Within this group 9 infants of greater than 36 weeks' gestation were matched to a group of 20 control infants without esophageal atresia. Infants with esophageal atresia had a significantly lower median plasma gastrin (38 ng/L v 55 ng/L, P less than .05). This may indicate preexisting vagal abnormalities in esophageal atresia unrelated to surgical intervention.
Davenport
M
M
Sub Department of Paediatric Surgery, St Mary's Hospital, Manchester, England.
Mughal
M
M
McCloy
R F
RF
Doig
C M
CM
D001724:Birth Weight; D004933:Esophageal Atresia / Q000097:blood* / Q000150:complications / Q000601:surgery; D005755:Gastrins / Q000097:blood* / Q000172:deficiency; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D012016:Reference Values; D014138:Tracheoesophageal Fistula / Q000097:blood* / Q000150:complications / Q000601:surgery
D005755:Gastrins