title: Effect of hypobaric hypoxia on fiber type composition of the soleus muscle in the developing rat.
abstract: The fiber type composition of the soleus muscle was investigated in male Sprague-Dawley rats exposed to hypobaric hypoxia of 460 mm Hg from 5 to 12 weeks of age. The muscle fibers were classified as fast-twitch oxidative (FO) and slow-twitch (S) on the basis of adenosine triphosphatase (ATPase) and succinate dehydrogenase (SDH) reactions. Intermediate fibers (INT) with intermediate ATPase and high SDH reaction intensities were also examined. A type shift of muscle fibers from FO to INT and S was found in the control group during development. After exposure to hypoxia, the hypoxia group had a significantly greater percentage of FO fibers than the age-matched control group. There was no significant change in the total number of fibers in the muscle during development and after exposure to hypoxia. These results indicate that the increased percentage of FO fibers found in the developing rat under hypoxic conditions is due to a hypoxia-induced inhibition of the type shift of muscle fibers from FO to S during development.
authors.affiliation: College of Liberal Arts and Sciences, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Taguchi
authors.forename: C
authors.initials: C
authors.lastname: Hirofuji
authors.forename: H
authors.initials: H
authors.lastname: Takeuchi
authors.forename: A
authors.initials: A
authors.lastname: Ishihara
mesh_terms: D000818:Animals; D001273:Atmosphere Exposure Chambers; D000860:Hypoxia / Q000473:pathology*; D008297:Male; D024510:Muscle Development; D009132:Muscles / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains