title: Preparation and stability of intravenous solutions of sodium dichloroacetate (DCA).
abstract: An IV injection formulation of sodium dichloroacetate (DCA) was prepared without heat sterilization, and examined for stability. DCA is heat labile in aqueous solutions. Its decomposition involves dehalogenation and production of hydrogen ions. Decomposition occurs relatively rapidly at relatively low pH values, and is promoted by heating. Injection solutions should be prepared aseptically and sterilized by filtration. Solutions prepared aseptically and sterilized by filtration are stable stored at 4 degrees C for at least four yrs.
authors.affiliation: University of Florida, Gainesville.
authors.forename: P I
authors.initials: PI
authors.lastname: Chu
authors.forename: S H
authors.initials: SH
authors.lastname: Curry
authors.forename: T G
authors.initials: TG
authors.lastname: Baumgartner
authors.forename: G N
authors.initials: GN
authors.lastname: Henderson
authors.forename: P W
authors.initials: PW
authors.lastname: Stacpoole
mesh_terms: D003999:Dichloroacetic Acid / Q000138:chemical synthesis*; D004355:Drug Stability; D012996:Solutions
chemical_list: D012996:Solutions; D003999:Dichloroacetic Acid