title: Vaccine efficacy for reducing turbinate atrophy and improving growth rate in piggeries with endemic atrophic rhinitis.
abstract: Two vaccines, based on formalin-killed whole cells of toxigenic Pasteurella multocida type D and Bordetella bronchiseptica combined with a partially toxoided cell extract of P multocida, were prepared with Freund's incomplete adjuvant (vaccine 1) or by alum precipitation (vaccine 2). Each was tested for safety and efficacy in reducing the severity of nasal turbinate atrophy and improving the growth rate of pigs in three Western Australian commercial piggeries with endemic atrophic rhinitis. In safety experiments with vaccine 1, no adverse clinical effects were observed in vaccinated sows or their progeny. Piglets receiving vaccine 2 showed no injection site abnormalities, pyrexia or turbinate atrophy. In field trials, vaccine 1 significantly reduced the prevalence of moderate to severe nasal turbinate atrophy (Done score 3 to 5) when used in two piggeries (A and B). Progeny from vaccinated sows in piggery B also grew significantly faster than controls. When vaccine 2 was used in piggery A at a later date and in another piggery (C), growth rate was not improved in either piggery and the prevalence of moderate to severe turbinate atrophy was reduced only in piggery C.
authors.affiliation: Animal Health Division, Department of Agriculture, South Perth Western Australia.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kabay
authors.forename: A R
authors.initials: AR
authors.lastname: Mercy
authors.forename: J M
authors.initials: JM
authors.lastname: Lloyd
authors.forename: G M
authors.initials: GM
authors.lastname: Robertson
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D001284:Atrophy; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000009:adverse effects; D016950:Bordetella bronchiseptica / Q000276:immunology*; D005260:Female; D016979:Pasteurella multocida / Q000276:immunology*; D011247:Pregnancy; D012222:Rhinitis, Atrophic / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014420:Turbinates / Q000473:pathology; D015430:Weight Gain
chemical_list: D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines