title: Cytogenetic analysis of a United Kingdom series of non-Hodgkins lymphomas.
abstract: We describe cytogenetic analyses of cells derived from 40 non-Hodgkins lymphoma (NHL) node biopsies, 23 of which were from patients who had not been treated before biopsy. We noted that the chromosomes most frequently gained were X (32%), 12 (27%), and 3 (24%). Monosomies were much less common; loss of chromosome 13 (13.5%) was most frequent. Structural abnormalities primarily involved chromosomes 14 (70%), 1 (40.5%), 18 (38%), 6 (35%), and 17 (22%). Low-and high-grade disease showed similar patterns of structural changes; however, a markedly greater number of chromosome gains were associated with low-grade disease. Biopsy samples from patients who had previously been treated showed an increased frequency of structural abnormalities, as well as a significantly larger number of chromosome gains. The importance of these observations, particularly with regard to possible oncogene involvement in lymphoma evolution, is discussed.
authors.affiliation: Department of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, England.
authors.forename: D W
authors.initials: DW
authors.lastname: Hammond
authors.forename: J R
authors.initials: JR
authors.lastname: Goepel
authors.forename: M
authors.initials: M
authors.lastname: Aitken
authors.forename: B W
authors.initials: BW
authors.lastname: Hancock
authors.forename: A M
authors.initials: AM
authors.lastname: Potter
authors.forename: M H
authors.initials: MH
authors.lastname: Goyns
mesh_terms: D000782:Aneuploidy; D002869:Chromosome Aberrations; D002883:Chromosomes, Human, Pair 14; D002886:Chromosomes, Human, Pair 17; D002887:Chromosomes, Human, Pair 18; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007621:Karyotyping; D008198:Lymph Nodes / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*