Discontinuing medication in epileptic children: a study of risk factors related to recurrence.
We studied 70 children who had experienced at least two seizures before age 12 years, excluding febrile seizures, neonatal seizures, or seizures occurring during a metabolic, or infectious insult to the central nervous system (CNS) and who had been seizure free for at least 2 years. Twenty children (28.5%) experienced a recurrence, 75% during antiepileptic (AED) drug discontinuation or less than 6 months after discontinuation. Risk factors statistically related to seizure recurrence were greater than 10 seizures before seizure control, an abnormal EEG in the year before AED discontinuation, presence of focal neurologic signs and/or mental retardation, and presence of a mixed seizure pattern. Fourteen children (70%) with recurrence had two or more risk factors, whereas 36 (72%) without recurrence had no risk factor or only one. We conclude that a selected group of epileptic children who remain seizure-free for a period of at least 2 years can have AEDs discontinued based on presence or absence of risk factors.
Gherpelli
J L
JL
Department of Neurology, Clinics Hospital University of Sao Paulo Medical School, Brazil.
Kok
F
F
dal Forno
S
S
Elkis
L C
LC
Lefevre
B H
BH
Diament
A J
AJ
D000927:Anticonvulsants / Q000008:administration & dosage*; D002648:Child; D004334:Drug Administration Schedule; D004569:Electroencephalography; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D013375:Substance Withdrawal Syndrome / Q000209:etiology
D000927:Anticonvulsants