Cell death by apoptosis and its protective role against disease.
The involvement of cell death in control of tissue growth has long been neglected, but the description of apoptosis as cellular 'suicide', the functional opposite of mitosis, is now attracting more attention to this phenomenon. Physiologically unwanted cells are removed by apoptosis, and toxic chemicals and drugs may enhance or inhibit this type of cell death. These findings are providing new insights into the pathophysiology of a variety of diseases, and suggesting new therapeutic strategies.
Bursch
W
W
Institut für Tumorbiologie-Krebsforschung, Universität Wien, Austria.
Oberhammer
F
F
Schulte-Hermann
R
R
D000818:Animals; D016923:Cell Death / Q000502:physiology*; D004194:Disease; D006801:Humans