title: Variability in behavioral impairment involved in the rising and falling BAC curve.
abstract: The purpose of this pilot study was to measure variability in behavior impairment at specific levels of the rising and falling blood alcohol concentration (BAC) curve. Behavior impairment was measured for anticipation and reaction time in addition to a variety of visual skills. Also of interest was the variability in impairment involved at specific BAC levels under single-dose and double-dose conditions. The experimental design was a variation on a 2 x 2 factorial with repeated measures on the dose of alcohol. All subjects took part in two experimental sessions, single-dose and double-dose. Sixteen (8 male and 8 female) paid subjects ages 21-40 participated in the study. Testing procedures included repeated measures on reaction time, anticipation time, perceptual vision acuity and depth perception. Breath-alcohol measures were sampled continuously at 5-minute intervals and used to plot absorption time, peak BAC and elimination time. Results showed that the average peak BAC for the double-dose was significantly higher than that of the single-dose condition. However, there were no significant differences between the single-dose and double-dose condition in either absorption time or elimination time. The performance pattern for reaction time, anticipation time and depth perception showed more impairment in the rising BAC limb than in the falling BAC limb. It is noteworthy that specific individuals exhibited different levels of impairment at a given BAC level, depending on whether the session was single- or double-dose, suggesting that one's current BAC level is less a measure of impairment than is the total quantity of alcohol consumed. A follow-up procedure to examine practice effects was conducted on eight volunteer students. Identical testing procedures, using no alcohol, produced no significant practice effects after a 3-hour period.
authors.affiliation: Health Education Department, Pennsylvania State University, University Park 16802.
authors.forename: M E
authors.initials: ME
authors.lastname: Nicholson
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: C O
authors.initials: CO
authors.lastname: Airhihenbuwa
authors.forename: B S
authors.initials: BS
authors.lastname: Mahoney
authors.forename: R
authors.initials: R
authors.lastname: Christina
authors.forename: D W
authors.initials: DW
authors.lastname: Maney
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood* / Q000523:psychology; D000435:Alcoholic Intoxication / Q000097:blood* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects*; D014796:Visual Perception / Q000187:drug effects*
chemical_list: D000431:Ethanol