[Inhibitory effect of activated protein C and heparin on arterial thrombosis].
Activated protein C (APC) exerts an anticoagulant effect by inactivating coagulation factors Va and VIIIa, preferentially on the surface of the cell membrane, and may enhance fibrinolysis by inhibiting PAI-1. APC inhibits venous and microvascular thrombosis, as well as, platelet-rich thrombus formation on the Dacron graft inserted in the arteriovenous shunt. We examined the effect of APC and heparin on arterial thrombosis using small mesenteric arteries of the rat, in which platelet-rich thrombus formation was induced by segmental deep vessel injury and the changes were monitored using a video-microscope system. Both APC (0.9 and 3.0 mg/kg, iv) and heparin (300 and 1000 U/kg) inhibited thrombus formation similarly. APC did not prolong APTT compared with heparin. APC may inhibit arterial thrombosis after vascular damage without serious bleeding side effects.
Araki
H
H
Department of Pharmacology, Kumamoto University Medical School.
D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D015849:Plasminogen Inactivators / Q000378:metabolism; D011486:Protein C / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use*; D011517:Prothrombin Time; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy* / Q000517:prevention & control; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D015849:Plasminogen Inactivators; D011486:Protein C; D006493:Heparin; D010959:Tissue Plasminogen Activator