The implications of the failure to generate autoantibody-producing hybridomas from rat erythrocyte-immunized mice.
Injection of mice with rat erythrocytes (RRBC) has long been thought to provide an experimental model in which suppressor T cells (Ts) control autoimmunity. The basis of this is that whilst mice immunized with RRBC produce an antibody response, of which a proportion cross-reacts with autologous red cells, the RRBC-immunized recipients of RRBC-primed spleen cells make no, or little, autoantibody, and secondly because the transfer of this autoantibody-specific suppression can be abrogated by T-cell depletion of transferred spleen cells. Here an alternative explanation of these phenomena is described.
Elliott
J I
JI
Department of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, UK.
Cooke
A
A
D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D006825:Hybridomas / Q000276:immunology*; D051379:Mice; D051381:Rats; D013154:Spleen / Q000166:cytology
D001323:Autoantibodies