Recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils.
The effects of recombinant human superoxide dismutase (r-hSOD) on ischemic neuronal injury were examined. Cerebral ischemia was produced in Mongolian gerbils by occluding bilateral common carotid arteries for 5 min. Preischemic treatment with r-hSOD clearly reduced hippocampal neuronal damages while postischemic treatment did not. This result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hSOD has a potential clinical usefulness against cerebral ischemia.
Tagaya
M
M
First Department of Internal Medicine, Osaka University Medical School, Japan.
Matsumoto
M
M
Kitagawa
K
K
Niinobe
M
M
Ohtsuki
T
T
Hata
R
R
Ogawa
S
S
Handa
N
N
Mikoshiba
K
K
Kamada
T
T
D000704:Analysis of Variance; D000818:Animals; D002545:Brain Ischemia / Q000473:pathology / Q000503:physiopathology*; D016923:Cell Death / Q000187:drug effects; D005260:Female; D005849:Gerbillinae; D006207:Half-Life; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology*
D011994:Recombinant Proteins; D013482:Superoxide Dismutase