title: The effects of two different local anaesthetic solutions administered for oral surgery on plasma potassium levels in patients taking kaliuretic diuretics.
abstract: The effects of two different dental local anaesthetic solutions, administered for oral surgery, on the plasma potassium levels of patients taking non-potassium sparing diuretics has been investigated. There was a significant reduction in plasma potassium concentration in eight subjects who received 4.4 ml of 2% lignocaine with 1:80,000 adrenaline; the mean reduction from baseline being 0.30 mmol.l-1 10 min following intraoral extravascular injection of the local anaesthetic. There was no significant difference from the pre-treatment plasma potassium concentration 10 min following similar injections of 3% prilocaine with 0.03 IU.ml-1 felypressin in 8 patients; the mean change in these subjects being -0.05 mmol.l-1. It is suggested that the use of adrenaline-free local anaesthetics would seem to be appropriate in patients receiving kaliuretic diuretics.
authors.affiliation: Department of Oral Surgery, Dental School, University of Newcastle upon Tyne, UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Meechan
authors.forename: M D
authors.initials: MD
authors.lastname: Rawlins
mesh_terms: D000368:Aged; D000766:Anesthesia, Dental; D000772:Anesthesia, Local; D004232:Diuretics / Q000627:therapeutic use; D004837:Epinephrine / Q000032:analysis* / Q000627:therapeutic use; D005259:Felypressin / Q000032:analysis / Q000627:therapeutic use; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D011318:Prilocaine / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D013515:Surgery, Oral
chemical_list: D004232:Diuretics; D011318:Prilocaine; D005259:Felypressin; D008012:Lidocaine; D011188:Potassium; D004837:Epinephrine