Antioxidant effect of calmodulin antagonists in rat brain homogenate.
Several calmodulin antagonists, W-7, amitriptyline, trifluoperazine, chlorpromazine, dibucaine, prenylamine, calmidazolium, and compound 48/80, inhibited lipid peroxidation induced non-enzymatically in rat brain homogenate by ascorbate and Fe2+. Suggestions of involvement of calmodulin in various oxidative cellular responses, based on experiments using calmodulin antagonists, may need to be re-evaluated.
Hara
S
S
Department of Forensic Medicine, Tokyo Medical College, Japan.
Endo
T
T
Kuriiwa
F
F
Kano
S
S
Iwata
N
N
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D007093:Imidazoles / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000187:drug effects; D013449:Sulfonamides / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000975:Antioxidants; D002147:Calmodulin; D007093:Imidazoles; D010640:Phenothiazines; D013449:Sulfonamides; D003189:p-Methoxy-N-methylphenethylamine; C031938:calmidazolium; C017967:W 7; C031637:phenothiazine