[Cardiovascular effect of norepinephrine in the habenular nucleus and the underlying mechanism in rats].
Cardiovascular effect of norepinephrine (NE) in the habenular nucleus (Hb) and the underlying mechanism were investigated in urethane-anesthetized rats. NE microinjection into Hb produced a dose-dependent increase in mean arterial blood pressure and heart rate, an effect that could be attenuated by the pretreatment in Hb with alpha-receptor blocker phentolamine, but not by the pretreatment with beta-receptor blocker propranolol or physiological saline. Microinjection of kainic acid into Hb gave rise to a marked increase in mean arterial blood pressure and heart rate, but microinjection of lidocaine did not elicit significant cardiovascular effect. The above results suggest that NE in Hb plays an important role in cardiovascular control as a result of Hb excitation through activation of alpha-receptor.
Yang
S N
SN
Department of Physiology, Norman Bethune University of Medical Sciences, Changchun.
Wang
S
S
Tang
Y H
YH
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013787:Thalamic Nuclei / Q000502:physiology*
D007608:Kainic Acid; D009638:Norepinephrine; D010646:Phentolamine