[A mechanism for reducing intraocular pressure in normal volunteers using UF-021, a prostaglandin-related compound].
The mechanism of reduction of intraocular pressure (IOP) and other ocular effects were studies after topical application of prostaglandin (PG) F2 alpha and UF-021, a new PG related compound, in eight normal volunteers. IOP, aqueous humor flow rate and outflow rate were evaluated during a period of four hours after the application. Both PGF2 alpha and UF-021 caused significant and similar IOP reduction for four hours. Neither compound produced any significant change in the aqueous humor flow rate or outflow rate, suggesting the increase of unconventional outflow rate as being the possible mechanism of IOP reduction in normal human eyes.
Tetsuka
H
H
Department of Ophthalmology, Tokyo Women's Medical College, Daini Hospital, Arakawa-ku, Japan.
Tsuchisaka
H
H
Kin
K
K
Takahashi
Y
Y
Takase
M
M
D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects / Q000502:physiology; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male
C072630:isopropyl unoprostone; D015237:Dinoprost