1-H-localized magnetic resonance spectroscopy: preliminary observations in transient ischemic attacks.
Water-suppressed proton magnetic resonance spectroscopy which has recently shown diagnostic potential in human stroke victims was performed in two patients who had suffered a hemispheric transient ischemic attack. Localized spectra were targeted from routine MR images. In one patient lactate could be observed 8 weeks after a transient ischemic attack. Lactate concentration was low compared with that of a patient who had suffered acute stroke. The other TIA patient did not show evidence of lactate production. Although these observations are preliminary, we demonstrated that localized in vivo proton spectroscopy can detect persistent biochemical alterations after transient ischemic attacks. We suggest that non-invasive in vivo proton spectroscopy will become a useful method in diagnosis and management of TIA in the future.
Felber
S
S
Department of Magnetic Resonance, University of Innsbruck, Austria.
Luef
G
G
Aichner
F
F
D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology*; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged
D007773:Lactates; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate