[Effect of gene db dose on the development of beta-cytotropic and immunotropic effects of long-term glibenclamide administration in C57BL/KsJY mice].
The studies have revealed a modifying influence of gene db on the expressivity of damaging beta-cytotropic effect of long-term sulphanilamide therapy and on the development of autoimmune cell response to antigens of pancreatic islets. It is substantiated as promising to study a significance of individual genes and their doses in determining the variations of reactivity to beta-cytotropic and immunotropic effects of the chemical nature factors.
Gladkikh
A I
AI
Poltorak
V V
VV
Brindak
O I
OI
Blokh
K O
KO
Berestovskaia
E V
EV
Koshel'
S P
SP
D000818:Animals; D015551:Autoimmunity / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005905:Glyburide / Q000008:administration & dosage*; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains
D005905:Glyburide
Vliianie dozy gena db na razvitie beta-tsitotropnogo i immunotropnogo éffektov dlitel'nogo vvedeniia glibenklamida u mysheĭ C57BL/KsJY.