Dose proportionality study of loperamide following oral administration of loperamide oxide.
The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
Kamali
F
F
Wolfson Unit of Clinical Pharamcology, The University, Newcastle upon Tyne, UK.
Adriaens
L
L
Huang
M L
ML
Woestenborghs
R
R
Emanuel
M
M
Rawlins
M D
MD
D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D001682:Biological Availability; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008139:Loperamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D008297:Male
D008139:Loperamide; C066043:loperamide oxide