title: The 13C NMR study of the binding of gold(I) thiomalate with ergothionine in aqueous solution.
abstract: The interaction of gold(I) thiomalate (Autm) (Myocrysine) with ergothionine (ErSH) has been studied in aqueous solution at pH 7.4. It was found that ErSH forms a ternary complex of the type ErS-Au-tm at a 1:1 mole ratio; unlike other thiols (e.g., cysteine and glutathione) it does not eject thiomalate (Htm) as a free ligand. However, in the presence of glutathione (GtSH), both ligands, ErSH as well as Htm, from the ErS-Au-tm complex were freed. The 13C NMR chemical shifts of C-2 resonance of ergothionine in the presence of Autm shifts greater than imidazolidine-2-thione (Imt) and 1,3-Diazinane-2-thione (Diaz), indicating the stronger complexation of ErS-Au-tm compared to Imt-Au-tm and Diaz-Au-tm.
authors.affiliation: King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: Isab
mesh_terms: D002247:Carbon Isotopes; D004880:Ergothioneine / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D006052:Gold Sodium Thiomalate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D015394:Molecular Structure; D012709:Serum Albumin / Q000737:chemistry; D012996:Solutions
chemical_list: D002247:Carbon Isotopes; D008024:Ligands; D012709:Serum Albumin; D012996:Solutions; D006052:Gold Sodium Thiomalate; D004880:Ergothioneine; D005978:Glutathione