title: Intracellular transport of MHC class II molecules.
abstract: MHC class II molecules associate, during biosynthesis, with peptides derived from endocytosed antigen. Here, Jacques Neefjes and Hidde Ploegh describe the intracellular transport of MHC class II molecules and its relationship to the binding of peptides in endosomal compartments. They discuss alternative routes for the delivery of antigen to sites at which peptides associate with MHC class II molecules and raise the possibility of cell type-specific differences in the handling of MHC class II molecules, and hence in antigen presentation.
authors.affiliation: The Netherlands Cancer Institute, Amsterdam.
authors.forename: J J
authors.initials: JJ
authors.lastname: Neefjes
authors.forename: H L
authors.initials: HL
authors.lastname: Ploegh
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism*; D000941:Antigens / Q000276:immunology / Q000378:metabolism*; D001665:Binding Sites; D001692:Biological Transport; D004705:Endocytosis; D004721:Endoplasmic Reticulum / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D010587:Phagocytosis
chemical_list: D000941:Antigens; D000949:Histocompatibility Antigens Class II; D010446:Peptide Fragments