title: High-energy phosphate metabolism of the myocardium in normal subjects and patients with various cardiomyopathies--the study using ECG gated MR spectroscopy with a localization technique.
abstract: Nuclear magnetic resonance spectroscopy (MRS) is a new technique for the evaluation of myocardial metabolism. Recently, localized MRS has been clinically available to measure by a non-invasive method the relative concentrations of the high-energy phosphate metabolites in the myocardium. We performed ECG gated P-31 MRS using ISIS (image-selected in vivo spectroscopy) in 15 normal volunteers, 12 patients with hypertrophic cardiomyopathy, 12 with left ventricular hypertrophy, 6 with dilated cardiomyopathy and 11 with specific heart muscle disease. Myocardial peak height ratios of PCr/gamma-ATP, Pi/gamma-ATP and PCr/Pi were measured. Myocardial P-31 MRS demonstrated a significant decrease in the ratio PCr/ATP in patients with hypertrophic cardiomyopathy and specific heart muscle disease as compared with normal subjects, indicating myocardial metabolic disturbance in these patients. The ratio of PCr/ATP in patients with dilated cardiomyopathy did not differ significantly from that of normal subjects. However, exercise MRS revealed a marked decrease of PCr peak in an asymptomatic patient with dilated cardiomyopathy, which may indicate a latent metabolic disturbance in the myocardium of dilated cardiomyopathy.
authors.affiliation: Third Department of Internal Medicine, Chiba University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Tateno
authors.forename: H
authors.initials: H
authors.lastname: Ikehira
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: F
authors.initials: F
authors.lastname: Shishido
authors.forename: M
authors.initials: M
authors.lastname: Sekiya
authors.forename: Y
authors.initials: Y
authors.lastname: Imazeki
authors.forename: H
authors.initials: H
authors.lastname: Imai
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Inagaki
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D009202:Cardiomyopathies / Q000378:metabolism*; D004562:Electrocardiography; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010755:Organophosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism
chemical_list: D010755:Organophosphates; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate