Platinum antitumour agents: a review of (bio)analysis.
This paper summarizes analytical techniques in order to get a clear picture of the ins and outs of the (bio)analysis of platinum-containing compounds. The antitumour agent cisplatin has become an indispensable drug for the cure of a variety of cancer diseases. Since its introduction in the early seventies, about 2,000 related platinum complexes were designed to devoid the dose-limiting nephrotoxicity. Some of them were introduced for clinical trial, such as carboplatin and iproplatin. To investigate the mechanism of action and pharmaco-kinetic behaviour, several interesting assays for total and specific platinum determination in biological matrices have been developed, each with its own possibilities and limitations.
Hodes
T J
TJ
Department of Pharmaceutical Analysis, Faculty of Pharmacy, State University of Utrecht, The Netherlands.
Underberg
W J
WJ
Los
G
G
Beijnen
J H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010984:Platinum / Q000032:analysis*; D011048:Polarography; D012995:Solubility; D013053:Spectrophotometry
D000970:Antineoplastic Agents; D010984:Platinum