Membrane-associated phospholipase A2 detected by a radioimmunoassay is a sensitive marker of inflammation in rheumatoid arthritis.
To investigate the clinical significance of membrane-associated phospholipase A2 (M-PLA2) measured by a radioimmunoassay(RIA) in rheumatoid arthritis, we examined serum M-PLA2 concentrations in 16 patients with rheumatoid arthritis. All showed elevated levels of serum M-PLA2. On the other hand, serum concentrations of C-reactive protein (CRP) and IL-6 were increased in 13 (81.3%) and 14 (87.5%) of 16 patients, respectively. The serum concentrations of M-PLA2 were significantly correlated with those of CRP. These results indicate that M-PLA2 is an acute phase reactant and a sensitive and useful marker of inflammation in rheumatoid arthritis.
Sakamoto
K
K
Department of Surgery II, Kumamoto University Medical School, Japan.
Arakawa
H
H
Yamashita
S
S
Mizuta
H
H
Takaki
K
K
Ogawa
M
M
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000201:enzymology; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D002462:Cell Membrane / Q000201:enzymology; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011863:Radioimmunoassay
D015415:Biomarkers; D015850:Interleukin-6; D008565:Membrane Proteins; D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2