[Chronic myelomonocytic leukemia associated with translocation 1;7, marked platelet aggregation and cryofibrinogenemia: a case report].
A 64-year-old male was admitted in September 1989 with complaints of fever and muscular weakness in the extremities. A peripheral blood examination on admission revealed WBC 10,300/microliters (monocytes 32%), RBC 195 x 10(4)/microliters, Hb 7.9 g/dl, Plt 12.8 x 10(4)/microliters with trilineage dysplasia. Bone marrow biopsy was normoplastic marrow with 25.7% of monocytes including immature blasts. Cytochemical analysis of the monocytes showed positive for peroxidase and dual esterase staining. Chromosomal analysis of peripheral blood revealed 46, XY, -7, +der(1) t(1;7)(p11;p11). A diagnosis of chronic myelomonocytic leukemia was made. Hemostatic studies revealed cryofibrinogenemia, marked platelet aggregation on blood smear, hyperfibrinogenemia and a marked increase in maximal amplitude of thrombelastogram. Treatment with prednisolone and VP16, resulted in a reduction of peripheral monocytes and a disappearance of cryofibrinogen, marked platelet aggregation and a decrease in muscular weakness. Nine months after diagnosis he died of DIC, pneumonia, lung abscess and sepsis.
Hino
K
K
Department of Hematology, Showa University, School of Medicine.
Sato
S
S
Ueno
H
H
Akimoto
Y
Y
Sakashita
A
A
Tomoyasu
S
S
Mochizuki
S
S
Kamino
I
I
Tsuruoka
N
N
D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D003080:Cold Temperature; D015241:Fibrinogens, Abnormal / Q000378:metabolism*; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D014178:Translocation, Genetic
D015241:Fibrinogens, Abnormal