Additivity of threshold elevations produced by disruption of outer hair cell function.
We present a simple model describing the additivity of hearing loss in the mammalian cochlea produced by disruption of the outer hair cell transduction processes. The validity of this model has been tested experimentally in the guinea-pig by inducing threshold elevations using two simultaneous cochlear manipulations, including acoustic overstimulation, two-tone suppression, low-frequency acoustic biasing of the cochlear partition and electrical stimulation of the medial olivo-cochlear system of efferent fibres. The results of these experiments suggest that the model presented is an adequate description, within the measurement error of our experiments, of the hearing losses produced.
Patuzzi
R
R
Department of Physiology, University of Western Australia, Nedlands.
Rajan
R
R
D000161:Acoustic Stimulation; D000200:Action Potentials; D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000502:physiology; D004558:Electric Stimulation; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000502:physiology*; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology; D009847:Olivary Nucleus / Q000502:physiology