title: Long-term effects of adjuvant tamoxifen and/or radiotherapy. The South Sweden Breast Cancer Trial.
abstract: In a multicenter trial of adjuvant therapy in stage II breast cancer, 719 postmenopausal patients were randomized to one of three treatment regimens: radiotherapy only or in combination with adjuvant tamoxifen for one year, or adjuvant tamoxifen without radiotherapy. At twelve years of follow-up (median 9 years), no statistically significant differences in survival or recurrence-free survival were observed. However, the rate of loco-regional recurrency was lower among patients treated with both radiotherapy and tamoxifen. The rate of bilateral breast cancer was reduced in tamoxifen-treated patients whereas the rate of new primary malignancies other than breast cancer was somewhat higher in tamoxifen-treated patients. Adjuvant therapy in breast cancer may influence not only breast cancer recurrences and mortality but also later disease patterns and cause-specific mortality.
authors.affiliation: Dept of Surgery, Angelholm Hospital, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Rydén
authors.forename: M
authors.initials: M
authors.lastname: Fernö
authors.forename: T
authors.initials: T
authors.lastname: Möller
authors.forename: K
authors.initials: K
authors.lastname: Aspegren
authors.forename: L
authors.initials: L
authors.lastname: Bergljung
authors.forename: D
authors.initials: D
authors.lastname: Killander
authors.forename: T
authors.initials: T
authors.lastname: Landberg
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002423:Cause of Death; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000401:mortality; D013548:Sweden; D013629:Tamoxifen / Q000627:therapeutic use*
chemical_list: D013629:Tamoxifen