Anaesthetic interaction between thiopentone and ketamine.
The anaesthetic effect of thiopentone, ketamine and their combinations were studied in 150 patients of ASA Grades I and II. The ability to open eyes on command and purposeful motor response to noxious pressure on the trapezius muscle were used as endpoints of anaesthesia. Dose-response curves for thiopentone, ketamine and their combinations were determined with a probit procedure and compared with isobolographic analysis. The interaction between thiopentone and ketamine was found to be additive for both endpoints of anaesthesia.
Roytblat
L
L
Department of Anaesthesiology, Soroka Medical Centre, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Katz
J
J
Rozentsveig
V
V
Gesztes
T
T
Bradley
E L
EL
Kissin
I
I
D000328:Adult; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D007649:Ketamine; D008875:Middle Aged; D011897:Random Allocation; D013874:Thiopental
D007649:Ketamine; D013874:Thiopental