[Anesthesia and acute hepatic porphyrias].
Acute hepatic porphyrias are inherited disorders of heme biosynthesis. A characteristic feature of acute porphyrias is the occurrence of acute attacks which are often precipitated by drugs. Many of the commonly used anaesthetic agents may trigger such a potentially lethal attack. Thus, only safe agents should be administered to predisposed patients. Recommendations given are based on results from animal experiments and on a series of anecdotal reports. Regional anaesthesia is presented as anaesthetic technique of choice. General anaesthesia should be based on a fentanyl-nitrous oxide regimen, with propofol as induction agent. In the case of an acute attack, treatment consists of glucose and haematin administration.
Böhrer
H
H
Klinik für Anästhesiologie, Universität Heidelberg.
Schmidt
H
H
Martin
E
E
D000777:Anesthetics / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D006801:Humans; D008107:Liver Diseases / Q000150:complications*; D011164:Porphyrias / Q000150:complications*; D013514:Surgical Procedures, Operative
D000777:Anesthetics
Anästhesie und akute hepatische Porphyrien.