Synergism exerted by 4-methyl catechol, catechol, and their respective quinones on the rate of DL-DOPA oxidation by mushroom tyrosinase.
4-Methyl catechol and catechol, at concentrations ranging from 0.03 to 9 mM and 0.066 to 20 mM, respectively, have a synergistic effect on the rate of DL-DOPA oxidation by mushroom tyrosinase to material absorbing at 475 nm. The synergism results from the ability of 4-methyl catechol-o-quinone (4-methyl-o-benzoquinone) and of catechol-o-quinone (o-benzoquinone) to oxidize DL-DOPA non-enzymatically to dopaquinone, with the later being immediately converted to dopachrome (lambda max = 475 nm).
Schved
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F
Department of Food Science, Volcani Center, Bet Dagan, Israel.
Kahn
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V
D001487:Basidiomycota / Q000201:enzymology*; D016227:Benzoquinones / Q000494:pharmacology; D002396:Catechols / Q000494:pharmacology*; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D045563:Indolequinones; D007211:Indoles / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects*; D011809:Quinones / Q000378:metabolism / Q000494:pharmacology*
D016227:Benzoquinones; D002396:Catechols; D045563:Indolequinones; D007211:Indoles; D011809:Quinones; C018599:4-methylcatechol; C001123:dopachrome; D004295:Dihydroxyphenylalanine; D014442:Monophenol Monooxygenase