title: Inhibitory effect of green tea on tumorigenesis by chemicals and ultraviolet light.
abstract: Topical application of a green tea polyphenol fraction inhibited 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in CD-1 mice previously initiated with 7,12-dimethylbenz[a]anthracene (DMBA). Oral administration of a green tea infusion as the sole source of liquid sustenance to SKH-1 mice inhibited ultraviolet B light (UVB)-induced sunburn lesions, UVB-induced initiation of skin tumors, UVB-induced formation of skin tumors in mice previously initiated with DMBA, and nitrosodiethylamine-induced forestomach and lung tumors in A/J mice. In addition to inhibiting UVB-induced formation of skin tumors in DMBA-initiated mice, oral administration of green tea markedly decreased tumor size.
authors.affiliation: Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers, State University of New Jersey, Piscataway 08854.
authors.forename: A H
authors.initials: AH
authors.lastname: Conney
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
authors.forename: M T
authors.initials: MT
authors.lastname: Huang
authors.forename: C T
authors.initials: CT
authors.lastname: Ho
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents; D015197:Carcinogenicity Tests; D005260:Female; D005419:Flavonoids; D051379:Mice; D008812:Mice, Hairless; D009369:Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental; D009381:Neoplasms, Radiation-Induced; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D012878:Skin Neoplasms / Q000209:etiology; D013662:Tea / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D016588:Anticarcinogenic Agents; D005419:Flavonoids; D010636:Phenols; D011108:Polymers; D059808:Polyphenols; D013662:Tea