Vimentin expression by Reed-Sternberg cells in Hodgkin's disease.
The expression of vimentin in Reed-Sternberg cells in 61 samples of Hodgkin's disease (HD) was examined using an avidin-biotin-peroxidase complex technique. Forty biopsies (66%) expressed vimentin, and expression was seen in all subtypes of HD. No immunophenotypic differences between vimentin-positive and vimentin-negative cases were noted. The significance of such expression is unclear, but may be related to the alterations in growth and differentiation that are typical of neoplastic cells.
Angel
C A
CA
Department of Pathology, University of Sheffield Medical School, UK.
Cullen
R A
RA
Pringle
J H
JH
Lauder
I
I
D006689:Hodgkin Disease / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016539:Reed-Sternberg Cells / Q000378:metabolism* / Q000473:pathology; D014746:Vimentin / Q000378:metabolism*
D014746:Vimentin