Experimental autoimmune uveoretinitis (EAU) versus experimental allergic encephalomyelitis (EAE): a comparison of T cell-mediated mechanisms.
EAU is a model of ocular inflammatory disease. EAU resembles another T cell-mediated autoimmune disease--experimental allergic encephalomyelitis--since both have increased expression of MHC class II molecules in the target tissue, can be adoptively transferred by activated CD4+ T cells and are inhibited by cyclosporin A. The immunological findings will be compared to find out if the same cellular mechanisms are involved in both diseases.
Calder
V L
VL
Department of Clinical Science, Institute of Ophthalmology, London, UK.
Lightman
S L
SL
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology*; D001812:Blood-Brain Barrier; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology*; D007167:Immunotherapy; D012173:Retinitis / Q000209:etiology*; D013601:T-Lymphocytes / Q000502:physiology*; D014605:Uveitis / Q000209:etiology*