Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus.
Tyromycin A, a new inhibitor of leucine and cysteine aminopeptidases has been isolated from mycelial cultures of the basidiomycete Tyromyces lacteus (Fr.) Murr. Its structure was established as 1,16-bis-[4-methyl-2,5-dioxo-3-furyl]hexadecane (1) by spectral analysis and transformation into ester and imide derivatives.
Weber
W
W
Lehrbereich Biotechnologie, Universität Kaiserslautern, Federal Republic of Germany.
Semar
M
M
Anke
T
T
Bross
M
M
Steglich
W
W
D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D001487:Basidiomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D005663:Furans; C075407:tyromycin A; D000626:Aminopeptidases; C075408:cysteine aminopeptidase; D007931:Leucyl Aminopeptidase