In vitro expressed HPV 8 E6 protein does not bind p53.
The oncogene E6 of human papillomavirus 8, which is associated with skin cancers in epidermodysplasia verruciformis, was transcribed and translated in vitro. The resulting 17 kDa protein did not bind to the cellular p53 in contrast to E6 of HPV16.
Steger
G
G
Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität, Erlangen, Federal Republic of Germany.
Pfister
H
H
D003001:Cloning, Molecular; D004268:DNA-Binding Proteins; D004819:Epidermodysplasia Verruciformis / Q000382:microbiology*; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D011485:Protein Binding; D011994:Recombinant Proteins / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D004268:DNA-Binding Proteins; C052603:E6 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral; D011994:Recombinant Proteins; D016159:Tumor Suppressor Protein p53