[Intravenous immunoglobulin in the prevention of infections in high-risk pediatric neurosurgery].
Sixty-four children undergoing "high risk" neurosurgery, were submitted in a comparative study performed to investigate the prophilactic effect of IgIv in reducing the risk of postoperative sepsis. Patients were divided in two groups that weren't different as to underlying disease, age and sex. 32 patients received IgIv 0.2 g/kg on day 0, day 2, day 5, day 12 and 32 placebo. IgIv reduced the number of postoperative respiratory and urinary infective events, thus resulting in a marked reduction of the therapeutic use of antibiotics. No side effects of administration of IgIv were observed.
Scielzo
R
R
Sezione di Neuroanestesia, USL 40, Ospedale Santobono, Napoli.
Caramazza
L
L
Circone
R
R
Graziano
D V
DV
D000293:Adolescent; D001424:Bacterial Infections / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D007231:Infant, Newborn; D019635:Neurosurgical Procedures; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control*; D012307:Risk Factors
D016756:Immunoglobulins, Intravenous
Immunoglobuline endovena (IgEv) nella prevenzione delle infezioni in neurochirurgia pediatrica ad alto rischio.