title: [Structural characterization of an unknown metabolite of ciprofloxacin].
abstract: The chemical structure of an unknown metabolite of ciprofloxacin (CAS 85721-33-1) is characterized by means of reversed phase ion pair liquid chromatography, absorption and fluorescence spectroscopy, partition coefficients as well as chemical and enzymatic hydrolytic degradation. A chemical structure of the unknown metabolite is proposed: N-formyl-desethylen-ciprofloxacin. It can be formed as an intermediate in the oxidative degradation of ciprofloxacin via oxociprofloxacin to desethylen-ciprofloxacin, or it may be formed by conjugation of desethylen-ciprofloxacin with formic acid. The amounts found in plasma and urine of patients were in the range of desethylen-ciprofloxacin, i.e. about 1% of the parent compound.
authors.affiliation: Lehrstuhl für Pharmakologie der Universität Regensburg.
authors.forename: F
authors.initials: F
authors.lastname: Kees
authors.forename: W
authors.initials: W
authors.lastname: Raasch
authors.forename: H
authors.initials: H
authors.lastname: Grobecker
mesh_terms: D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D010084:Oxidation-Reduction; D013050:Spectrometry, Fluorescence
chemical_list: D002939:Ciprofloxacin
vernacular_title: Strukturelle Charakterisierung eines unbekannten Metaboliten von Ciprofloxacin.