Effect of surfactant phase in perfluorocarbon emulsification efficiency.
The effect of preparation temperature on the emulsification efficiency of perfluoro-3-butyltetrahydrofuran (FC-75) was investigated. Polyoxyethylene (POE) oleyl ether surfactants were used as the emulsifier(s) in a range of HLB values of 7.5 to 9.5. The emulsions were prepared by paddle mixing as a method of low-shear emulsification. After centrifugation of the resulting O/W emulsions, the volume of FC-75 which separated was utilized as a measure of the emulsification efficiency. In general, emulsions prepared at temperatures where the surfactant was in a lamellar-to-isotropic surfactant solution transition, L alpha----L3, displayed a better emulsification efficiency than those prepared with other surfactant phases.
Pasternacki-Surian
J M
JM
ICI Pharmaceuticals Group, Wilmington, Delaware 19897.
Schnaare
R L
RL
Sugita
E T
ET
D004355:Drug Stability; D004655:Emulsions; D005466:Fluorocarbons / Q000378:metabolism*; D013501:Surface-Active Agents / Q000494:pharmacology*
D004655:Emulsions; D005466:Fluorocarbons; D013501:Surface-Active Agents