Oral administration of tranexamic acid in the management of traumatic hyphema in children.
In a prospective study 163 patients aged 17 years or less admitted to a children's hospital between April 1985 and December 1990 with traumatic hyphema were treated with tranexamic acid, 25 mg/kg given orally every 8 hours to a maximum of 1500 mg every 8 hours for 5 days. Secondary hemorrhage occurred in 5 patients (3%), none of whom had more than one rebleeding episode. In contrast, 24 (8%) of 316 patients aged 17 years or less admitted to the same hospital between January 1977 and March 1985 with traumatic hyphema who were not treated with antifibrinolytics had a secondary hemorrhage, several more than once, giving a rebleeding rate of 33/316 (10%). The results suggest that tranexamic acid reduces the incidence and number of secondary hemorrhages in children, without significant ocular or systemic side effects.
Deans
R
R
Department of Ophthalmology, Children's Hospital of Eastern Ontario, Ottawa.
Noël
L P
LP
Clarke
W N
WN
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005131:Eye Injuries / Q000150:complications / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006988:Hyphema / Q000209:etiology / Q000517:prevention & control*; D015994:Incidence; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012008:Recurrence; D014148:Tranexamic Acid / Q000008:administration & dosage*
D014148:Tranexamic Acid