Sex difference in the nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with DL-buthionine sulphoximine.
In ICR mice depleted of glutathione (GSH) by treatment with DL-buthionine sulphoximine (BSO), males were much more susceptible to thiabendazole (TBZ) nephrotoxicity than females. The nephrotoxicity was indicated by increases in relative kidney weight and serum urea nitrogen (SUN) concentration and by a decrease in renal GSH concentration at 24 hr after TBZ administration. The susceptibility of males to TBZ-induced nephrotoxicity was completely eliminated by pretreatment with oestradiol (OD). Castration of male mice also reduced, though not completely, their susceptibility to TBZ nephrotoxicity. In females pretreated with testosterone (TS), the nephrotoxic effect of TBZ was increased to an extent comparable with that in males.
Mizutani
T
T
Department of Food Science and Nutrition, Kyoto Prefectural University, Japan.
Yoshida
K
K
Ito
K
K
Kawazoe
S
S
D000818:Animals; D000963:Antimetabolites / Q000009:adverse effects*; D019328:Buthionine Sulfoximine; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005978:Glutathione / Q000172:deficiency; D007279:Injections, Subcutaneous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000187:drug effects; D012737:Sex Factors; D013739:Testosterone / Q000494:pharmacology; D013827:Thiabendazole / Q000037:antagonists & inhibitors / Q000633:toxicity*
D000963:Antimetabolites; D008717:Methionine Sulfoximine; D013739:Testosterone; D004958:Estradiol; D019328:Buthionine Sulfoximine; D005978:Glutathione; D013827:Thiabendazole