Impact of chronic phosalone toxicity on Bohr factor and oxygen equilibrium curves of rat.
The multiple sublethal doses of phosalone induced changes in haemodynamics, maximum absorption spectra, oxygen equilibrium curves (OEC), half saturation tension (P50), degree of interaction (n), pH of blood, Bohr factor and circulatory gases of blood in rat, Rattus norvegicus. The results have obviously shown that increase the activation of pyridoxal phosphate, shift of OEC to right and decrease in the affinity of haemoglobin for oxygen at tissue level.
Reddy
S J
SJ
Pesticide and Industrial Toxicology Centre, Department of Zoology, Sri Venkateswara University, Tirupati, India.
Reddy
B V
BV
Ramamurthi
R
R
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D006863:Hydrogen-Ion Concentration; D008297:Male; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000378:metabolism*; D011732:Pyridoxal Phosphate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D009946:Organothiophosphorus Compounds; D010108:Oxyhemoglobins; D002245:Carbon Dioxide; C003117:phosalone; D011732:Pyridoxal Phosphate; D010100:Oxygen