Adjuvanticity of stearyl tyrosine on the antibody response to peptide 503-535 from HIV gp160.
In this present report we compare the humoral immune response induced by immunization with an HIV-1 gp160 peptide corresponding to amino acid sequence 503-535 complexed with different adjuvants. Specifically, the antipeptide, anti-HIV-1 gp160 and neutralizing antibody responses were measured in groups of mice and baboons that received peptide 503-535 conjugated to a carrier protein in either saline, alum, or stearyl tyrosine. The highest antibody responses were induced when mice and baboons were immunized with peptide adsorbed on stearyl tyrosine. These data indicate that stearyl tyrosine represents a potent candidate as a nontoxic adjuvant not only for subunit viral vaccines, but also for HIV peptides.
Nixon
A
A
Department of Microbiology, Mount Sinai School of Medicine, New York, New York.
Zaghouani
H
H
Penney
C L
CL
Lacroix
M
M
Dionne
G
G
Anderson
S A
SA
Kennedy
R C
RC
Bona
C A
CA
D000276:Adjuvants, Immunologic; D000818:Animals; D015686:Gene Products, env / Q000276:immunology*; D015483:HIV Antibodies / Q000096:biosynthesis*; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D019302:HIV Envelope Protein gp160; D015497:HIV-1 / Q000276:immunology; D007114:Immunization; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis / Q000276:immunology; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D010215:Papio; D010446:Peptide Fragments / Q000276:immunology; D011498:Protein Precursors / Q000276:immunology*; D011863:Radioimmunoassay; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000276:immunology
D000276:Adjuvants, Immunologic; D015686:Gene Products, env; D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120; D019302:HIV Envelope Protein gp160; D007132:Immunoglobulin Isotypes; D010446:Peptide Fragments; D011498:Protein Precursors; D014443:Tyrosine; C045245:stearyl tyrosine