Receptor binding on whole cells can oscillate.
The study of the kinetics of binding of the opiate receptor agonist [3H]DADLE with NG108-15 cell suspensions has revealed a new periodic biological phenomenon, i.e., oscillations of the cellular receptor activity. The absence of oscillations for binding of the receptor antagonist shows that oscillations occur as a result of the transformation of the receptor signal only.
Sukhomlin
T K
TK
Research Center of Molecular Diagnostics, Moscow, Russia.
Melikhova
E M
EM
Kurochkin
I N
IN
Varfolomeev
S D
SD
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D004174:Diprenorphine / Q000378:metabolism*; D016308:Enkephalin, Leucine-2-Alanine / Q000378:metabolism*; D007700:Kinetics; D011955:Receptors, Drug / Q000378:metabolism*; D012680:Sensitivity and Specificity
D011955:Receptors, Drug; D004174:Diprenorphine; D016308:Enkephalin, Leucine-2-Alanine