Cefonicid versus cefuroxime: an in vitro study of 1,000 Enterobacteriaceae.
Cefuroxime and cefonicid, two common representatives of the second-generation cephalosporins, were compared for their spectrum of activity against 1,000 isolates of gram-negative Enterobacteriaceae. Cefuroxime had an overall advantage of 6.3% over cefonicid. Upon investigation, we found that this was mainly due to Escherichia coli: 11.2% of the E. coli strains proved resistant to cefonicid whilst only 0.4% were cefuroxime resistant.
Keness
J
J
Microbiology Laboratory, Emek Medical Center, Afula, Israel.
Efrati
Z
Z
Raz
R
R
D015790:Cefonicid / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests
D015790:Cefonicid; D002444:Cefuroxime