title: Hibernating myocardium: a historical perspective.
abstract: Hibernating myocardium refers to the presence of persistent myocardial and left ventricular dysfunction at rest, associated with conditions of severely reduced coronary blood flow. This left ventricular dysfunction probably represents an adaptive mechanism preventing irreversible myocardial cell damage, since myocardial and left ventricular dysfunction in hibernating myocardium improve following the restoration of coronary blood flow. This review examines the evolution of the concept of hibernation from a clinical observation of the potential underlying mechanisms recently proposed.
authors.affiliation: Department of Medicine, University of Southern California, Los Angeles.
authors.forename: J F
authors.initials: JF
authors.lastname: Tubau
authors.forename: S H
authors.initials: SH
authors.lastname: Rahimtoola
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D015536:Down-Regulation; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D009206:Myocardium / Q000378:metabolism; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D000255:Adenosine Triphosphate