Susceptibility of biofilm cells of Pseudomonas aeruginosa to bactericidal actions of whole blood and serum.
The planktonic and young biofilm cells (harvested on day 2) of mucoid Pseudomonas aeruginosa were susceptible to the bactericidal actions of whole blood and serum. Aging biofilms of this organism (harvested on day 7) were very resistant to the killing effect of whole blood and serum. From this study we propose that the establishment of aging biofilms may contribute to persistence of this organism in biofilm-associated infections.
Anwar
H
H
Department of Microbiology, University of Alberta, Edmonton, Canada.
Strap
J L
JL
Costerton
J W
JW
D004783:Environmental Microbiology; D011552:Pseudomonas Infections / Q000453:epidemiology; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity / Q000502:physiology*; D015610:Serum Bactericidal Test / Q000379:methods*; D014774:Virulence