[Farquhar disease. Reduced phagocyte function in a 9-year-old girl with erythrophagocytic lymphohistiocytosis].
We report phagocyte function tests in a female infant with familial hemophagozytotic lymphohistiocytosis. Chemiluminescence and killing of Saccharomyces cerevisiae by monocytes and granulocytes before chemotherapy and in remission were examined. Patients' monocytes and granulocytes showed a markedly reduced chemiluminescence and killing capacity irrespective of the stage of disease.
Schroten
H
H
Zentrum für Kinderheilkunde, Heinrich-Heine-Universität Düsseldorf.
Kampmann
A
A
Sperzel
M
M
Jürgens
H
H
Seger
R
R
Wahn
V
V
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D006644:Histiocytes / Q000187:drug effects / Q000276:immunology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007223:Infant; D008163:Luminescent Measurements; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D010586:Phagocytes / Q000187:drug effects / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects / Q000235:genetics* / Q000276:immunology; D012441:Saccharomyces cerevisiae / Q000276:immunology
M. Farquhar. Verminderte Phagozytenfunktion bei einem 9 Monate alten Mädchen mit erythrophagozytärer Lymphohistiozytose.