title: Influence of a menhaden oil diet on cercarial penetration of Schistosoma mansoni.
abstract: The ability of a menhaden oil (MO) diet to influence cercarial penetration into mouse tail skin was evaluated. Male CD-1 mice 4-6 wk old (15.2 g average weight) were fed a 0, 10%, or 20% MO-supplemented diet for 2 wk. After this time mice were infected with either 65 +/- 3 or 145 +/- 3 [35S]methionine/cysteine-labeled cercariae for 1 hr by tail immersion. Twenty-four hours and 7 days later groups of mice were killed and their tail skin removed and autoradiographed. At 24 hr postinfection, mice fed a 20% MO diet had significantly higher cercarial penetration than controls and 10% MO diets (56% +/- 5.2 vs. 44% +/- 2.9, P = 0.02, 1-tailed t-test). After 7 days mice fed a 20% MO diet retained more radioactive foci than controls or 10% MO diets (21% +/- 2.0 vs. 15% +/- 1.3, P = 0.01, 1-tailed t-test).
authors.affiliation: University of Illinois College of Medicine, Department of Biomedical Sciences, Rockford 61107.
authors.forename: A C
authors.initials: AC
authors.lastname: Fusco
authors.forename: S
authors.initials: S
authors.lastname: Weaver
authors.forename: B
authors.initials: B
authors.lastname: Salafsky
authors.forename: T
authors.initials: T
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000627:therapeutic use; D005395:Fish Oils / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011897:Random Allocation; D012550:Schistosoma mansoni / Q000502:physiology*; D012555:Schistosomiasis mansoni / Q000178:diet therapy* / Q000517:prevention & control; D013623:Tail / Q000469:parasitology
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; C033266:Menhaden oil