[Plasminogen activator inhibitor 1--a new thrombosis risk marker].
The plasma activity of plasminogen activator inhibitor 1 (PAI-1) was measured in 278 clinically healthy subjects (98 men, 180 women; mean age 26 [18-50] years). In 198 of them there were factors increasing the risk of thrombosis, such as smoking, over-weight and/or oral contraceptives. PAI-1 activity was within normal range (less than 4 U/ml) in male nonsmokers of normal weight and in female nonsmokers not taking oral contraceptives. In male smokers (5.76 +/- 1.93 U/ml) and in overweight subjects of both sexes (7.49 +/- 1.87 U/ml) PAI-1 was increased up to 10.6 U/ml as an indication of decreased fibrinolysis capacity. Nonsmoking females on oral contraceptives had lower PAI-1 levels (2.72 +/- 0.86 U/ml) than nonsmokers without hormonal intake (3.21 +/- 1.03 U/ml; P less than 0.001). Apparently the increased risk of thrombosis that occurs on oral contraceptives is not due to increased PAI-1 activity.
Hoang
N H
NH
Institut für Blutgerinnung und Transfusionsmedizin, Universität Düsseldorf.
Kuntz
B M
BM
Brüster
H T
HT
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D003276:Contraceptives, Oral / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D015849:Plasminogen Inactivators / Q000097:blood*; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects; D013927:Thrombosis / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology*
D015415:Biomarkers; D003276:Contraceptives, Oral; D015849:Plasminogen Inactivators
Plasminogenaktivator-Inhibitor 1--ein neuer Thromboserisiko-Marker.