title: AML with unusual chromosomal changes. Translocation (15;21) and 5q- in the presence of two normal chromosomes 5.
abstract: We performed serial cytogenetic studies of the bone marrow (BM) of a patient with acute myeloblastic leukemia (AML) and noted abnormal karyotypes 47,XY,+del(5)(q12q34),t(15;21)(q21;q22)/47,XY,+del(5)(q12q34 ) during the second relapse. Although a case of this t(15;21) was recently observed in a female patient with acute nonlymphocytic leukemia (ANLL) of subtype M4 of the French-American-British (FAB) classification, the present article constitutes the first report of its occurrence in association with ANLL of subtype M1-M2. Furthermore, the presence of the 5q- accompanied by two chromosomes 5 of normal appearance is very rare and of great interest.
authors.affiliation: Cytogenetics Service, Faculty of Medicine, University of La Laguna, Canary Islands, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Carrasco Juan
authors.forename: A
authors.initials: A
authors.lastname: Otero Gómez
authors.forename: J L
authors.initials: JL
authors.lastname: Garcia Miranda
authors.forename: M L
authors.initials: ML
authors.lastname: Brito Barroso
authors.forename: M T
authors.initials: MT
authors.lastname: Hernández García
authors.forename: L
authors.initials: L
authors.lastname: Hernández Nieto
mesh_terms: D000328:Adult; D002884:Chromosomes, Human, Pair 15; D002891:Chromosomes, Human, Pair 21; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*