title: Leukemic evolution in three patients with myelodysplastic syndrome and unusual chromosome changes.
abstract: The authors describe three patients with myelodysplastic syndrome without a history of exposure to chemical agents and who showed many chromosome rearrangements not previously reported in this hematologic disorder, and a rapid outcome of the disease. The authors discuss the significance of the chromosome changes, suggesting, in agreement with others, that patients with complex rearrangements have a poor prognosis.
authors.affiliation: Istituto di Biologia e Genetica, Università di Chieti, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Palka
authors.forename: G
authors.initials: G
authors.lastname: Calabrese
authors.forename: L
authors.initials: L
authors.lastname: Stuppia
authors.forename: P
authors.initials: P
authors.lastname: Guanciali Franchi
authors.forename: A
authors.initials: A
authors.lastname: Antonucci
authors.forename: A
authors.initials: A
authors.lastname: Spadano
authors.forename: R
authors.initials: R
authors.lastname: Di Lorenzo
authors.forename: G
authors.initials: G
authors.lastname: Torlontano
mesh_terms: D000208:Acute Disease; D000368:Aged; D002869:Chromosome Aberrations; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D011379:Prognosis