title: Cell-matrix response in tendon injury.
abstract: The healing response after tendon injury is defined by cell matrix adaptive capability. There are distinct macrotraumatic and microtraumatic injury patterns and a spectrum of pathologic responses from inflammation to tissue degeneration, as characterized by the tendinosis phenomenon. Epigenetic and genetic factors govern recovery from tendon injury. The potential for future modulation of injury repair by protein mediators or growth factors appears promising.
authors.affiliation: Department of Orthopaedic Surgery, Georgetown University, Washington, DC.
authors.forename: W B
authors.initials: WB
authors.lastname: Leadbetter
mesh_terms: D000125:Achilles Tendon / Q000098:blood supply / Q000473:pathology / Q000648:ultrastructure; D000208:Acute Disease; D001265:Athletic Injuries / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000473:pathology / Q000502:physiology*; D006801:Humans; D008854:Microscopy, Electron; D010146:Pain / Q000209:etiology; D052256:Tendinopathy / Q000503:physiopathology; D013708:Tendon Injuries / Q000473:pathology / Q000503:physiopathology*; D009626:Terminology as Topic; D014945:Wound Healing / Q000502:physiology