title: No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families.
abstract: Evidence for a pseudoautosomal locus for a schizophrenia susceptibility gene was sought by two forms of analysis of 25 multiply affected families. Firstly, in the sample as a whole there was an excess of same-sex over mixed-sex siblings compared with that expected. Secondly, linkage analysis was performed in six of the families. The genotypes were studied for DXYS14, a highly polymorphic marker in the telomeric pseudoautosomal region. No evidence for positive linkage was found with two-point analysis under eight different genetic models for the mode of transmission. A non-parametric, sibling-pair analysis also failed to detect linkage. Our findings provide no evidence for linkage within the pseudoautosomal region; same-sex concordance must arise from some other mechanism.
authors.affiliation: Department of Psychological Medicine, University of Wales College of Medicine, Cardiff.
authors.forename: P
authors.initials: P
authors.lastname: Asherson
authors.forename: E
authors.initials: E
authors.lastname: Parfitt
authors.forename: M
authors.initials: M
authors.lastname: Sargeant
authors.forename: S
authors.initials: S
authors.lastname: Tidmarsh
authors.forename: P
authors.initials: P
authors.lastname: Buckland
authors.forename: C
authors.initials: C
authors.lastname: Taylor
authors.forename: A
authors.initials: A
authors.lastname: Clements
authors.forename: M
authors.initials: M
authors.lastname: Gill
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
authors.forename: M
authors.initials: M
authors.lastname: Owen
mesh_terms: D015139:Blotting, Southern; D002874:Chromosome Mapping; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D008297:Male; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012730:Sex Chromosomes
chemical_list: D015342:DNA Probes; D004247:DNA