Recognition of correct reading frame by the ribosome.
The translation frame-monitoring mechanism has been suggested earlier, based on transient complementary contacts, between mRNA and rRNA. Recent studies related to the frame-monitoring mechanism are reviewed. The mechanism is well supported by both new experimental and sequence analysis data. Experiments are suggested for further elucidation of the structural details of the mRNA-rRNA interaction in the ribosome.
Trifonov
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Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel.
D001483:Base Sequence; D008957:Models, Genetic; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics*; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics*; D016364:Reading Frames / Q000235:genetics*
D012333:RNA, Messenger; D012335:RNA, Ribosomal