title: Cell kinetics of melanocytes in common and dysplastic nevi and in primary and metastatic cutaneous melanoma.
abstract: The 3H-thymidine labelling (LI) and mitotic (MI) indexes were calculated in 29 cutaneous melanocytic lesions: 6 common nevi (CN), 11 dysplastic nevi, subclassified as nevi with architectural atypia (NAA = 4) and nevi with cyto-architectural atypia (NCAA = 7), 2 melanomas in situ (MIS), 4 invasive superficial spreading melanomas (IM) and 6 metastatic melanomas (MM). The LI mean values resulted to be: CN = 0.23%, NAA = 0.98%, NCAA = 1.79%, MIS = 5.75%, IM = 5.16%, MM = 3.80%. In CN, NAA, NCAA and MIS, these values were calculated at epidermal level; in IM and MM at dermal level. At dermal level, the LI mean values of CN, NAA and NCAA were: 0.20%, 0.20%, 0.23% respectively. The MI mean value was close to 0 in CN, NAA, NCAA, MIS; 0.18% in IM, 0.16% in MM. Confirming a low proliferative activity in CN and a high activity in melanomas (MIS, IM, MM), the results showed that dysplastic nevi (NAA, NCAA) had a proliferative activity intermediate between common nevi and melanomas. The lesions with melanocytic atypia (NCAA) resulted to have a higher proliferative activity than those without this histological feature (NAA).
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università di Firenze, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Urso
authors.forename: R
authors.initials: R
authors.lastname: Bondi
authors.forename: M
authors.initials: M
authors.lastname: Balzi
authors.forename: E
authors.initials: E
authors.lastname: Scubla
authors.forename: P
authors.initials: P
authors.lastname: Mauri
authors.forename: A
authors.initials: A
authors.lastname: Becciolini
authors.forename: S
authors.initials: S
authors.lastname: Tarocchi
authors.forename: C
authors.initials: C
authors.lastname: Vallecchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002455:Cell Division / Q000502:physiology; D002648:Child; D004416:Dysplastic Nevus Syndrome / Q000473:pathology*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D008545:Melanoma / Q000473:pathology* / Q000556:secondary; D008875:Middle Aged; D008940:Mitotic Index / Q000502:physiology*; D009506:Nevus / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*