No increase in relapse in patients with myeloid leukaemias receiving rhGM-CSF after allogeneic bone marrow transplantation.
Twenty patients with leukaemia received recombinant human GM-CSF (rhGM-CSF) after allogeneic bone marrow transplantation (BMT) in a double blind controlled trial, with a significant promotion of granulopoiesis when compared with 20 control patients. The follow-up in survivors is now sufficiently long to assess the potential for promotion of relapse in the patients with myeloid leukaemias. Six patients with myeloid leukaemias are alive 22-38 months after transplantation. Eight other patients with myeloid leukaemias died within 12 weeks of transplantation without active active disease. None of these 14 patients with myeloid leukaemias have relapsed. This study supports the view that rhGM-CSF does not increase the probability of relapse after allogeneic BMT in patients with myeloid leukaemia.
Gupta
P
P
Leukaemia Unit, Royal Marsden Hospital, Sutton, Surrey, UK.
Tiley
C
C
Powles
R
R
Treleaven
J
J
Millar
J
J
Catalano
J
J
D016026:Bone Marrow Transplantation; D004311:Double-Blind Method; D005500:Follow-Up Studies; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D007951:Leukemia, Myeloid / Q000601:surgery*; D012008:Recurrence; D014184:Transplantation, Homologous
D016178:Granulocyte-Macrophage Colony-Stimulating Factor