Amitriptyline produces analgesia in the formalin pain test.
A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans. Since the analgesic effect was produced by a single dose, which is insufficient to produce an antidepressant effect, these results indicate that amitriptyline has analgesic properties that are independent of its antidepressant properties.
Acton
J
J
Department of Psychology, McGill University, Montreal, Quebec, Canada.
McKenna
J E
JE
Melzack
R
R
D000639:Amitriptyline / Q000494:pharmacology*; D000698:Analgesia; D000700:Analgesics / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D005557:Formaldehyde; D008297:Male; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012016:Reference Values; D013997:Time Factors
D000700:Analgesics; D000639:Amitriptyline; D005557:Formaldehyde