title: Influence of diets containing cow's milk or soy protein beverage on plasma lipids in children with familial hypercholesterolemia.
abstract: The present article summarizes the effects of diets containing either cow's milk or soy protein beverage on plasma lipids and lipoproteins in children with familial hypercholesterolemia. After a stabilization period of 6 weeks without any hypolipemic medication, 10 subjects aged 6-12 years were randomly assigned to either cow's milk or soy protein beverage with subsequent crossover after a washout period, each of 4 weeks duration. During the experimental periods, subjects were fed diets containing 20% of energy as protein, of which 35% was from cow's milk protein or soy protein isolate, 28% of energy as fat with a polyunsaturated:monounsaturated:saturated fat ratio of 1:3:3, and less than 200 mg/day of cholesterol. The soy protein beverage, compared to cow's milk, induced significant reductions in plasma triglycerides and very-low-density lipoprotein cholesterol, as well as a significant increase in high-density lipoprotein cholesterol, indicating that consumption of soy protein beverage may be beneficial for the prevention of coronary heart disease in children with familial hypercholesterolemia.
authors.affiliation: Department of Human Nutrition and Consumer Studies, Laval University, Quebec, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Jacques
authors.forename: D
authors.initials: D
authors.lastname: Laurin
authors.forename: S
authors.initials: S
authors.lastname: Moorjani
authors.forename: F H
authors.initials: FH
authors.lastname: Steinke
authors.forename: C
authors.initials: C
authors.lastname: Gagné
authors.forename: D
authors.initials: D
authors.lastname: Brun
authors.forename: P J
authors.initials: PJ
authors.lastname: Lupien
mesh_terms: D000328:Adult; D000818:Animals; D001628:Beverages; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D003327:Coronary Disease / Q000517:prevention & control; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000178:diet therapy*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008892:Milk; D014674:Plant Proteins, Dietary / Q000008:administration & dosage*; D030262:Soybean Proteins; D013025:Glycine max; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008074:Lipoproteins; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D014280:Triglycerides