Therapeutic effects of hidrosmin on chronic venous insufficiency of the lower limbs.
A double-blind, placebo-controlled trial was carried out to assess the effectiveness of a new synthetic bioflavonoid, hidrosmin, in patients with chronic venous insufficiency of the lower limbs. Fifty-seven patients, showing varicose veins and ankle swelling and suffering from local pain and heaviness of the legs, were allocated at random to receive treatment for 45 days with 1 capsule 3-times daily of either 200 mg hidrosmin (30 patients) or placebo (27 patients). Pain and heavy legs were assessed using rating scales; swelling was assessed by a photographic method. The results showed that hidrosmin produced a significant clinical improvement in all of the parameters evaluated; compared with placebo, there was a marked reduction in the main subjective symptoms accompanied by a 10% reduction in swelling. Apart from 1 patient who complained of epigastric pain, there were no reports of adverse events during the study period.
Domínguez
C
C
Vascular Surgery Services, University Hospital of the Canary Islands, Tenerife, Spain.
Brautigam
I
I
González
E
E
González
J A
JA
Nazco
J
J
Valiente
R
R
Boada
J
J
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004145:Diosmin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D004487:Edema / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014689:Venous Insufficiency / Q000188:drug therapy*
C071047:hidrosmin; D004145:Diosmin