title: Hereditary spherocytosis: experience of 145 cases.
abstract: 145 patients were diagnosed to have hereditary spherocytosis (HS) over a period of 25 years. Jaundice (66.9%), fever (65.5%), weakness (44.8%), and abdominal pain (35.8%) were the commonest complaints. 94.5% had splenomegaly (JP-17 cm) and 71.7% had hepatomegaly (JP-6 cm). Spherocytes were detected in the peripheral smears of all patients at presentation on careful examination. 67 patients had been investigated elsewhere and spherocytes missed in 86.6%. Gall stones were seen in 20 of the 54 patients investigated. Family history suggestive of HS was available in only 16.6% of cases, whereas examination and investigations revealed HS in almost all families. Splenectomy was done in all symptomatic patients. In the 39 patients followed up for 1-9 years after splenectomy.
authors.affiliation: JC Patel Department of Hematology, KEM Hospital, Bombay.
authors.forename: J
authors.initials: J
authors.lastname: Mehta
authors.forename: K
authors.initials: K
authors.lastname: Harjai
authors.forename: J
authors.initials: J
authors.lastname: Vasani
authors.forename: P
authors.initials: P
authors.lastname: Banghar
authors.forename: M
authors.initials: M
authors.lastname: Sanklecha
authors.forename: S
authors.initials: S
authors.lastname: Singhal
authors.forename: A
authors.initials: A
authors.lastname: Pathare
authors.forename: G H
authors.initials: GH
authors.lastname: Tilve
authors.forename: B C
authors.initials: BC
authors.lastname: Mehta
authors.forename: J C
authors.initials: JC
authors.lastname: Patel
mesh_terms: D000328:Adult; D000368:Aged; D002675:Child, Preschool; D003906:Developing Countries; D003937:Diagnosis, Differential; D005260:Female; D006452:Hemoglobinometry; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D013103:Spherocytosis, Hereditary / Q000175:diagnosis / Q000235:genetics*; D013156:Splenectomy