title: Evidence for a pseudoautosomal locus for schizophrenia. II: Replication of a non-random segregation of alleles at the DXYS14 locus.
abstract: Because of an association between sexual aneuploidies and schizophrenia, and because schizophrenic siblings have been found to be more often of the same than of the opposite sex, the susceptibility locus for schizophrenia is thought to lie within the pseudoautosomal region of the sex chromosomes. We analysed 33 sibships comprising 18 pairs, 13 trios, and 2 quartets of affected siblings, and found support for non-random segregation of of alleles at the DXYS14 locus in affected siblings. These findings are consistent with the pseudoautosomal hypothesis for schizophrenia and favour a genetic linkage between DXYS14 and the disease.
authors.affiliation: Laboratoire NBCM, CNRS UPR0023, Gif-sur-Yvette, France.
authors.forename: T
authors.initials: T
authors.lastname: d'Amato
authors.forename: D
authors.initials: D
authors.lastname: Campion
authors.forename: P
authors.initials: P
authors.lastname: Gorwood
authors.forename: M
authors.initials: M
authors.lastname: Jay
authors.forename: O
authors.initials: O
authors.lastname: Sabate
authors.forename: C
authors.initials: C
authors.lastname: Petit
authors.forename: M
authors.initials: M
authors.lastname: Abbar
authors.forename: A
authors.initials: A
authors.lastname: Malafosse
authors.forename: M
authors.initials: M
authors.lastname: Leboyer
authors.forename: D
authors.initials: D
authors.lastname: Hillaire
mesh_terms: D000483:Alleles; D015139:Blotting, Southern; D002874:Chromosome Mapping; D015342:DNA Probes; D005260:Female; D006801:Humans; D008126:Lod Score; D008297:Male; D012559:Schizophrenia / Q000235:genetics*; D012730:Sex Chromosomes
chemical_list: D015342:DNA Probes