Histaminergic response to Coriolis stimulation: implication for transdermal scopolamine therapy of motion sickness.
The blood levels of histamine and 5-hydroxytryptamine (5-HT) in 10 subjects, with or without administration of the transdermal therapeutic system of scopolamine (TTS-S), were measured following motion sickness (MS) induced by Coriolis stimulation. Histamine and 5-HT were assayed using the fluorometric method. The results demonstrated that the blood levels of histamine increased significantly following MS and were even higher in the subjects using TTS-S, but we found neither significant changes in the blood levels of 5-HT following MS nor any effect of TTS-S on it. The results suggest that histamine contributes to the development of MS, and scopolamine may exert its anti-MS action by affecting the histaminergic system as well as the acetylcholinergic system; there may not be a definite relation between 5-HT and the development of MS.
Wang
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ET
Department of Otolaryngology, General Hospital of Air Force, Beijing, P.R. China.
Zhou
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DR
He
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LH
D000279:Administration, Cutaneous; D000328:Adult; D003312:Coriolis Force; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000097:blood / Q000188:drug therapy*; D012601:Scopolamine / Q000008:administration & dosage*; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D006632:Histamine; D012601:Scopolamine