title: A reappraisal of chlamydial and nonchlamydial acute non-gonococcal urethritis.
abstract: A cohort of 112 men presenting with acute non-gonococcal urethritis (NGU) was investigated for the presence of Chlamydia trachomatis. Men with 3 or more episodes of NGU in the preceding 12 months, or who had received treatment for NGU in the preceding 3 months were excluded. C. trachomatis was sought by examination of urethral smears by direct immunofluorescence, and by examination of the centrifuged deposit from a first pass urine (FPU) sample by direct immunofluorescence, IDEIA, and the polymerase chain reaction. Urethral samples from 48 men were positive for CT, and the FPU samples from an additional 7 men were positive by at least 2 assays. With such intensive investigation it is likely that those men identified as chlamydia-negative were genuinely free from the infection. The clinical history and response to treatment of those men who were chlamydia-positive were compared with those of the chlamydia-negative men. They differed in that a larger proportion of the chlamydia-positive men reported having had intercourse with more than one partner in the previous 3 months, and having had fewer previous episodes of NGU. Moreover, in contrast to some previous studies, after one week of treatment with doxycycline, a larger proportion (65%) of the chlamydia-negative men than the chlamydia-positive men (40%) was cured, although the difference was not sustained following later treatment.
authors.affiliation: Division of Sexually Transmitted Diseases, Clinical Research Centre, Harrow, Middlesex, UK.
authors.forename: P E
authors.initials: PE
authors.lastname: Hay
authors.forename: B J
authors.initials: BJ
authors.lastname: Thomas
authors.forename: C
authors.initials: C
authors.lastname: Gilchrist
authors.forename: H M
authors.initials: HM
authors.lastname: Palmer
authors.forename: C B
authors.initials: CB
authors.lastname: Gilroy
authors.forename: D
authors.initials: D
authors.lastname: Taylor-Robinson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000188:drug therapy; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012725:Sexual Behavior; D012747:Sexual Partners; D014526:Urethritis / Q000188:drug therapy / Q000382:microbiology*