Pathogenesis of hypertrophic osteoarthropathy.
The systematic study of patients with cyanotic heart diseases has led to a better understanding of the pathogenesis of hypertrophic osteoarthropathy (HOA). Current evidence suggests that in cases of right-to-left shunts of blood, HOA develops as a result of faulty pulmonary clearance of macrothrombocytes. There are theoretical grounds to suggest that a platelet-derived growth factor is also responsible for the acropachy associated with other types of internal illnesses.
Martinez-Lavin
M
M
Rheumatology Department, Instituto Nacional de Cardiología Ignacio Chávez, México D.F.
D006801:Humans; D010004:Osteoarthropathy, Primary Hypertrophic / Q000209:etiology*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology*