Relationship of neural cell adhesion molecules (N-CAMs) with adenylate cyclase.
Bovine brain cDNA cloned earlier and attributed to calmodulin-independent adenylate cyclase encodes the neural cell adhesion molecule (N-CAM). The expression of N-CAM mRNA in Xenopus laevis oocytes increases their basal adenylate cyclase activity. Polyclonal antibodies against synthetic peptide A, VAENQQGKSKAAHFV (664-678 amino acid residues of bovine N-CAM), containing sequence AXXXXGKS which is homologous to the nucleotide-binding consensus sequence GXXXXGKS, inhibit the adenylate cyclase activity. A close relationship appears to exist between adenylate cyclase and N-CAM.
Lipkin
V M
VM
Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Surina
E A
EA
Petukhova
G V
GV
Petrov
V M
VM
Mirzoeva
S F
SF
Rakitina
T V
TV
D000262:Adenylyl Cyclases / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D003001:Cloning, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D014982:Xenopus laevis
D015816:Cell Adhesion Molecules, Neuronal; D000262:Adenylyl Cyclases