title: [Effect of gene db dose on the development of beta-cytotropic and immunotropic effects of long-term glibenclamide administration in C57BL/KsJY mice].
abstract: The studies have revealed a modifying influence of gene db on the expressivity of damaging beta-cytotropic effect of long-term sulphanilamide therapy and on the development of autoimmune cell response to antigens of pancreatic islets. It is substantiated as promising to study a significance of individual genes and their doses in determining the variations of reactivity to beta-cytotropic and immunotropic effects of the chemical nature factors.
authors.forename: A I
authors.initials: AI
authors.lastname: Gladkikh
authors.forename: V V
authors.initials: VV
authors.lastname: Poltorak
authors.forename: O I
authors.initials: OI
authors.lastname: Brindak
authors.forename: K O
authors.initials: KO
authors.lastname: Blokh
authors.forename: E V
authors.initials: EV
authors.lastname: Berestovskaia
authors.forename: S P
authors.initials: SP
authors.lastname: Koshel'
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000187:drug effects; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005260:Female; D005905:Glyburide / Q000008:administration & dosage*; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains
chemical_list: D005905:Glyburide
vernacular_title: Vliianie dozy gena db na razvitie beta-tsitotropnogo i immunotropnogo éffektov dlitel'nogo vvedeniia glibenklamida u mysheĭ C57BL/KsJY.