In vitro and in vivo ethanolamine metabolism in rat brain: effect of time and aging.
The effect of the time in culture of foetal rat neurons and age on the incorporation of radioactive ethanolamine into methylated derivatives was investigated. Decreased incorporation of [3H]ethanolamine into its various methylated water-soluble and lipidic derivatives was observed in rat neurons cultures at 12 day in vitro (DIV) as compared to the 3rd and the 7th DIV. In vivo studies showed that there was a diminished labeling of methylated products in the older animals as compared to the younger ones. These in vitro and in vivo observations suggest a generalized decrease of N-methyltransferase activities during maturation and aging.
Andriamampandry
C
C
Centre de Neurochimie du CNRS, Strasbourg, France.
Kanfer
J N
JN
Freysz
L
L
Dreyfus
H
H
Massarelli
R
R
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002478:Cells, Cultured; D019856:Ethanolamine; D004983:Ethanolamines / Q000378:metabolism*; D050356:Lipid Metabolism; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004983:Ethanolamines; D019856:Ethanolamine