Iopamidol in cardioangiography: a retrospective, multicenter study. Part I. Adult patients.
To evaluate the occurrence of complications during diagnostic or interventional catheterization a retrospective analysis of catheterization procedures in 12 Italian laboratories using the nonionic contrast medium (CM) iopamidol (370 mgI/ml) was performed. Data obtained on 26,219 patients greater than or equal to 14 years are presented. The overall complication rate was 1.89% (485/26,219). The overall mortality rate was 0.1% (27/26,219). Procedure related complications were 389 (1.48%) and CM related complications were 106 (0.4%). No death was attributed to CM. Ventricular fibrillation (VF) rate was 0.11% comparable to the low rate observed with nonionic CM in other studies and less than the rate observed in surveys concerning the use of ionic CM. Fifty-seven thrombotic events were recorded (0.22%), a rate comparable with other surveys with ionic and nonionic CM. The total complication rate (6.1%), the rates of coronary occlusion (1.34%), myocardial infarction (0.37%) and urgent coronary artery by-pass grafting (0.5%) in 1,348 coronary angioplasties were lower than those recorded in previous surveys. These data confirm a good tolerability and no increased risk of VF and thrombotic events with iopamidol in cardiac catheterization.
Ballerini
L
L
Dipartimento di Cardiologia Pediatrica, Ospedale Bambin Gesu Roma, Italy.
Barbaresi
F
F
Binaghi
G
G
Cernigliaro
C
C
Chioin
R
R
Fattori
R
R
Inglese
L
L
Invernizzi
G
G
Leto di Priolo
S
S
Passoni
F
F
D000328:Adult; D000367:Age Factors; D000790:Angiocardiography / Q000009:adverse effects / Q000379:methods* / Q000401:mortality / Q000706:statistics & numerical data; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D004341:Drug Evaluation; D006801:Humans; D007479:Iopamidol / Q000008:administration & dosage / Q000009:adverse effects; D007558:Italy / Q000453:epidemiology; D012189:Retrospective Studies; D012737:Sex Factors
D007479:Iopamidol