Severe neonatal nemaline myopathy--histological and histochemical studies of respiratory muscles.
The histological and histochemical findings in the respiratory muscles of a patient with severe neonatal nemaline myopathy are described. The patient suffered from frequent pneumonia associated with vomiting due to gastroesophageal reflux and died at 3 months from respiratory failure. The diaphragm was moderately involved and the intercostal muscles mildly involved. Core/targetoid structures were observed in the diaphragm and intercostal muscles.
Tachi
N
N
Department of Pediatrics, Sapporo Medical College, Japan.
Wakai
S
S
Watanabe
Y
Y
Kurosawa
Y
Y
Agatsuma
Y
Y
Chiba
S
S
D015897:Comorbidity; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D008297:Male; D009123:Muscle Hypotonia / Q000401:mortality / Q000503:physiopathology; D012120:Respiration Disorders / Q000209:etiology / Q000401:mortality / Q000503:physiopathology*; D012131:Respiratory Insufficiency / Q000401:mortality*; D012132:Respiratory Muscles / Q000473:pathology* / Q000648:ultrastructure