[The effect of two lubricants (magnesium stearate and pruv) in the formation of tablets of four anti-ulcer agents/ by means of direct compression].
In this research we study the influence of two lubricants-Magnesium Stearate and Pruv--on the tablets elaboration of Cimetidine, Ranitidine, Famotidine and Pirenzepine by direct compression. The presence of 0.5% of lubricants improved the flow of all the formulations, but especially the Famotidine's formulation. The formulations with Magnesium Stearate had the worst results in tests of friability and tensile strength. All tablets with drugs and Pruv had high data in indentation hardness. The tablets of Cimetidine, Famotidine and Pirenzepine with Magnesium Stearate had less time of disintegration.
Garcia Marquez
M A
MA
Departamento de Farmacia y Tecnologia Farmacéutica, Facultad de Farmacia, Tramontana, Sevilla.
Muñoz
A
A
Jiménez-Castellanos
M R
MR
D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D004339:Drug Compounding; D005079:Excipients; D005650:Fumarates; D013228:Stearates; D013229:Stearic Acids; D013607:Tablets
D000897:Anti-Ulcer Agents; D005079:Excipients; D005650:Fumarates; D013228:Stearates; D013229:Stearic Acids; D013607:Tablets; C075700:fumaric acid, monooctadecyl ester, sodium salt; C031183:stearic acid
Influence de deux lubrifiants (stéarate de magnésium et pruv) dans l'élaboration de comprimés de quatre anti-ulcéreux au moyen de la compression directe.