title: Continuous infusion of recombinant interleukin-2 with or without autologous lymphokine activated killer cells for the treatment of advanced renal cell carcinoma.
abstract: Data have been analysed for 327 patients with advanced renal cell carcinoma receiving a continuous infusion of recombinant interleukin 2 (rIL-2) alone (225 patients) or rIL-2 plus lymphokine activated killer (LAK) cells (102) on a normal oncology ward. Eligibility criteria were uniform across protocols, all patients having advanced progressive disease, but with an ambulatory performance status. The baseline characteristics of patients receiving rIL-2 alone did not differ significantly from those receiving LAK, with the exception that the LAK treated patients had a better performance status. Despite similar treatment intensity, toxicity was more severe in the patients receiving LAK. The addition of LAK did not lead to higher response rates or to prolonged response duration, progression-free survival or survival. This review confirms the activity of rIL-2 for the treatment of advanced renal cell carcinoma and demonstrates that the addition of LAK cells does not lead to increased efficacy.
authors.affiliation: Medical Department, EuroCetus BV, Amsterdam, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: Palmer
authors.forename: J
authors.initials: J
authors.lastname: Vinke
authors.forename: P
authors.initials: P
authors.lastname: Evers
authors.forename: C
authors.initials: C
authors.lastname: Pourreau
authors.forename: R
authors.initials: R
authors.lastname: Oskam
authors.forename: G
authors.initials: G
authors.lastname: Roest
authors.forename: F
authors.initials: F
authors.lastname: Vlems
authors.forename: L
authors.initials: L
authors.lastname: Becker
authors.forename: E
authors.initials: E
authors.lastname: Loriaux
authors.forename: C R
authors.initials: CR
authors.lastname: Franks
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007376:Interleukin-2 / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000628:therapy*; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D007376:Interleukin-2; D011994:Recombinant Proteins