Negative regulators of growth.
The proliferation of cells is regulated by countervailing positively- and negatively-acting signaling networks. The anti-proliferative signals, the study of which has been much neglected until recently, are often conveyed by growth-inhibitory peptides. Elements that mediate the cellular response to growth inhibitors are encoded by tumor suppressor genes that if lost may lead to the runaway growth of the cancer cell.
Massagué
J
J
Howard Hughes Medical Institute, New York, New York.
Weinberg
R A
RA
D016147:Genes, Tumor Suppressor; D006131:Growth Inhibitors / Q000235:genetics*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta
D006131:Growth Inhibitors; D016212:Transforming Growth Factor beta