Use of high-performance liquid chromatographic peak deconvolution and peak labelling to identify antiparasitic components in plant extracts.
Artemisia absynthium L. is a commonly used medicinal plant for parasitic diseases all over the world. By means of high-performance liquid chromatography with diode-array detection and the PU6100 solvent optimization system, two sesquiterpene lactones, alpha-santonin and ketopelenolid-A, were tentatively identified in methanolic extracts of this plant. alpha-Santonin is a well known antiparasitic compound and could be one of the active principles of this plant species. Reconstructed spectra are potentially useful in scanning a complex chromatogram for pharmacologically active compounds.
Perez-Souto
N
N
CENIC Quimica, Havana, Cuba.
Lynch
R J
RJ
Measures
G
G
Hann
J T
JT
D000818:Animals; D037621:Artemisinins; D002851:Chromatography, High Pressure Liquid; D007783:Lactones / Q000032:analysis / Q000494:pharmacology; D010271:Parasites / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry*; D012500:Santonin / Q000032:analysis / Q000494:pharmacology; D012717:Sesquiterpenes / Q000032:analysis / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet
D037621:Artemisinins; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; C075877:absynthin; D012500:Santonin; C075876:ketopelenolid-A; C075875:artemisin