The treatment of urinary incontinence in children using glutaraldehyde cross-linked collagen.
Periurethral injection of polytetrafluoroethylene (PolyTef) paste has been used to correct urinary incontinence for 2 decades. The controversy over distant migration of the paste has led to an interest in alternative materials particularly for the pediatric patient. Glutaraldehyde cross-linked collagen, derived from bovine dermal collagen, is effective in treating urinary incontinence in adults. Eight children with structural urinary incontinence underwent glutaraldehyde cross-linked collagen injection. Fluorourodynamic studies preceded and followed the injections. An average of 10.9 cc glutaraldehyde cross-linked collagen was injected per treatment (range 2.5 to 20). The number of injections per child ranged from 1 to 6 (mean 2.1) and followup averaged 13.75 months (range 6 to 33). Overall, 88% of the patients were cured or improved: 5 (63%) became continent, 2 were improved and 1 had no effect.
Wan
J
J
Section of Urology, University of Michigan Medical Center, Ann Arbor.
McGuire
E J
EJ
Bloom
D A
DA
Ritchey
M L
ML
D000293:Adolescent; D002648:Child; D003094:Collagen / Q000008:administration & dosage; D003432:Cross-Linking Reagents / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D005976:Glutaral / Q000008:administration & dosage; D006801:Humans; D007267:Injections; D008297:Male; D019736:Prostheses and Implants; D014549:Urinary Incontinence / Q000628:therapy*
D003432:Cross-Linking Reagents; D003094:Collagen; D005976:Glutaral