Effect of biliary decompression on reticuloendothelial function in jaundiced rats.
The recovery of reticuloendothelial system (RES) function following decompression of obstructive jaundice was studied using a rat model with bile duct ligation and side-to-side choledochoduodenostomy. Histopathological changes in the liver were still present 5 weeks after relief of jaundice, while results of liver function tests had returned to normal. RES function evaluated by the blood clearance and organ uptake of radiolabelled Escherichia coli using a corrected phagocytic index gradually returned to normal following biliary decompression. The severely impaired RES activity noted 1 week after operation may explain the increased incidence of sepsis and renal insufficiency in the early period after biliary surgery in jaundiced patients.
Ding
J W
JW
Department of Surgery, Lund University, Sweden.
Andersson
R
R
Stenram
U
U
Lunderquist
A
A
Bengmark
S
S
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002768:Choledochostomy; D002779:Cholestasis / Q000601:surgery*; D004195:Disease Models, Animal; D004926:Escherichia coli; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D008111:Liver Function Tests; D008168:Lung / Q000382:microbiology; D008297:Male; D012157:Mononuclear Phagocyte System / Q000503:physiopathology*; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000382:microbiology