Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins.
Replication competent chimeric viruses that express the gag and pol proteins of SIVmac and the env proteins of HIV-1 were made. One such chimeric virus, SHIV-4, that expresses the vif, vpx, vpr, and nef regulatory genes of SIV and the tat and rev regulatory genes of HIV-1 replicated efficiently in cynomolgus monkeys. This model system can be used to evaluate the efficacy of anti-HIV-1 vaccines directed at the envelope glycoproteins, anti-HIV-1 envelope glycoprotein antiserum or monoclonal antibodies, and anti-HIV-1 drugs designed to inhibit the tat, rev, or env functions.
Li
J
J
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
Lord
C I
CI
Haseltine
W
W
Letvin
N L
NL
Sodroski
J
J
D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D002678:Chimera; D005260:Female; D015686:Gene Products, env / Q000378:metabolism*; D015658:HIV Infections / Q000378:metabolism / Q000382:microbiology*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D008252:Macaca fascicularis; D008297:Male; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D016097:Simian Acquired Immunodeficiency Syndrome / Q000378:metabolism / Q000382:microbiology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000502:physiology; D014779:Virus Replication
D015686:Gene Products, env