Effect of atrazine on hemopoietic system.
For a long time some pesticides (chlordane, lindane, DDT) have been associated with bone marrow aplasia. Little is known on the toxic activity of the herbicides s-triazines on hemopoiesis. We studied the effect of one of these compounds (atrazine) on mouse hemopoietic progenitors (CFU-S and GM-CFC) and on peripheral blood (leukocytes and reticulocytes) after a single i.p. injection of 58.65 mg/kg. The peripheral blood leukocyte level was not modified; on the contrary, reticulocytes dropped severely but recovered promptly. Hemopoietic progenitors were severely hit but they recovered and reached normal levels in a few days. Our results demonstrate a hemotoxic effect of atrazine. However, more data are needed, especially in experiments with chronic exposure.
Mencoboni
M
M
Dipartimento di Medicina Interna (DI.M.I.), Università di Genova, Italy.
Lerza
R
R
Bogliolo
G
G
Flego
G
G
Pannacciulli
I
I
D000818:Animals; D001280:Atrazine / Q000494:pharmacology*; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA
D001280:Atrazine