Induction of mitochondrial alterations ex vivo in skeletal muscle.
The ultrastructural alterations of mitochondria were studied, following a fixation delay of 45 min, in the normal type II red muscle fibres of pigeon semimetapatagialis muscle. These muscle fibres, were devoid of myofibrillar degeneration; however, their mitochondria showed derangement. The latter included irregular orientation and loss of cristae, and clearing of the matrix. Some mitochondria showed myelin figures of varying complexity in the subsarcolemmal areas as well as in the interior of muscle fibres. These alterations bear striking resemblance to that seen during some lysosomal formation. The significance of these observations is discussed.
Khan
M A
MA
La Trobe University, Department of Human Biosciences, Bundoora Victoria, Australia.
D000818:Animals; D010856:Columbidae; D008931:Mitochondria, Muscle / Q000502:physiology / Q000648:ultrastructure*; D009132:Muscles / Q000648:ultrastructure; D016707:Tissue Fixation