The second human beta B2-crystallin gene is a pseudogene.
Comparison of the partial sequences of the human beta B2-1- and beta B2-2-crystallin genes with orthologous rat or calf sequences shows that the fourth exon sequence of the human beta B2-2 gene contains a one triplet deletion and a mutated splice acceptor site. No transcripts from the beta B2-2-crystallin gene could be detected in the human lens. These data suggest that the human beta B2-2-crystallin gene is a pseudogene.
Brakenhoff
R H
RH
Laboratory for Molecular Biology, University of Nijmegen, The Netherlands.
Aarts
H J
HJ
Schuren
F
F
Lubsen
N H
NH
Schoenmakers
J G
JG
D001483:Base Sequence; D015152:Blotting, Northern; D003459:Crystallins / Q000235:genetics*; D005091:Exons / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D015345:Oligonucleotide Probes; D011544:Pseudogenes / Q000502:physiology*
D003459:Crystallins; D015345:Oligonucleotide Probes