title: Synthesis and antitumour activity of sulfoalkyl derivatives of curdlan and lichenan.
abstract: 2-Sulfoethyl, 3-sulfopropyl, and 4-sulfobutyl derivatives of the (1----3)-beta-D-glucan curdlan and the (1----3/1----4)-beta-D-glucan lichenan have been synthesised. The substituents are located mainly at positions 6. The curdlan derivatives strongly inhibited the growth of the Sarcoma 180 tumour, whereas the lichenan derivatives were inactive, indicating that a (1----3)-linked beta-D-glucan backbone is essential for activity.
authors.affiliation: Institut für Pharmazie, Universität Regensburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Demleitner
authors.forename: J
authors.initials: J
authors.lastname: Kraus
authors.forename: G
authors.initials: G
authors.lastname: Franz
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents; D005260:Female; D005936:Glucans / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy*; D047071:beta-Glucans
chemical_list: D000970:Antineoplastic Agents; D005936:Glucans; D047071:beta-Glucans; C038459:curdlan; C015968:lichenin