title: A patient with monosomy 7 and polyuria.
abstract: Diabetes insipidus (DI) is a rare complication of leukaemia. An association between monosomy 7 and DI in leukaemias has been proposed. We present a case of Ph1-positive CML who developed polyuria at the time of lymphoid blast transformation associated with loss of chromosome 7. Biochemical results were not diagnostic of DI and a therapeutic trial of DDAVP was unsuccessful. Post-mortem showed a peripituitary and renal leukaemic infiltrate and although DI is a possibility, the cause of his polyuria remains unresolved.
authors.affiliation: Department of Haematology, Royal Victoria Hospital, Bournemouth, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Sadullah
authors.forename: A R
authors.initials: AR
authors.lastname: Kruger
authors.forename: S
authors.initials: S
authors.lastname: Barrington Onslow
authors.forename: M
authors.initials: M
authors.lastname: Armitage
authors.forename: D G
authors.initials: DG
authors.lastname: Oscier
mesh_terms: D001752:Blast Crisis / Q000150:complications / Q000235:genetics / Q000473:pathology; D002897:Chromosomes, Human, Pair 7; D003919:Diabetes Insipidus / Q000150:complications / Q000235:genetics; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000235:genetics / Q000473:pathology; D015466:Leukemia, Myeloid, Chronic-Phase / Q000150:complications / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D011141:Polyuria / Q000150:complications* / Q000235:genetics