title: Contingent tolerance and reresponse to carbamazepine: a case study in a patient with trigeminal neuralgia and bipolar disorder.
abstract: This retrospective single-case study demonstrates the development of tolerance and reresponse to carbamazepine in a patient with coexisting trigeminal neuralgia and manic-depressive illness. After an initial positive response, tolerance to the antinociceptive and psychotropic effects of carbamazepine appeared during treatment, despite increasing doses. As in preclinical studies of contingent tolerance, periods of carbamazepine discontinuation were associated with reresponse following reinstitution. These are the first clinical data interpreted in a contingent tolerance formulation with reresponse following a medication-free interval. Controlled and prospective studies are needed of the reliability and the pathophysiological and therapeutic implications of this phenomenon.
authors.affiliation: Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
authors.forename: P J
authors.initials: PJ
authors.lastname: Pazzaglia
authors.forename: R M
authors.initials: RM
authors.lastname: Post
mesh_terms: D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002220:Carbamazepine / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D010147:Pain Measurement; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D012189:Retrospective Studies; D014277:Trigeminal Neuralgia / Q000188:drug therapy* / Q000523:psychology
chemical_list: D002220:Carbamazepine