title: Supplementation with selenium-rich bread does not influence platelet aggregation in healthy volunteers.
abstract: In order to establish the effect of an increased dietary selenium supply on platelet glutathione peroxidase (EC 1.11.1.9.; GSH-Px) and platelet aggregation, six healthy subjects were supplemented with 200 micrograms Se as Se-rich bread for 6 weeks. Another six subjects received low-Se bread and served as controls. Platelet GSH-Px activity increased significantly in the supplementation group, whereas no effect could be observed on platelet aggregation. The results of this study do not support the hypothesis that an increased dietary Se intake has a favourable influence on platelet aggregation.
authors.affiliation: TNO Nutrition and Food Research, Zeist, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Van Dokkum
authors.forename: H W
authors.initials: HW
authors.lastname: Van der Torre
authors.forename: G
authors.initials: G
authors.lastname: Schaafsma
authors.forename: C
authors.initials: C
authors.lastname: Kistemaker
authors.forename: T
authors.initials: T
authors.lastname: Ockhuizen
mesh_terms: D000244:Adenosine Diphosphate; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000201:enzymology; D001939:Bread; D003094:Collagen; D004912:Erythrocytes / Q000737:chemistry; D005527:Food, Fortified / Q000592:standards*; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects* / Q000652:urine; D006801:Humans; D008297:Male; D010949:Plasma / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects*; D012643:Selenium / Q000097:blood / Q000494:pharmacology* / Q000652:urine
chemical_list: D000244:Adenosine Diphosphate; D003094:Collagen; D005979:Glutathione Peroxidase; D012643:Selenium