Role of aortic baroreceptors in ethanol-induced impairment of baroreflex control of heart rate in conscious rats.
This study investigated the relative contribution of aortic baroreceptors to the depressant effect of ethanol on arterial baroreceptor function. The acute hemodynamic effects of ethanol were studied in conscious freely moving aortic baroreceptor denervated (ABD) and sham-operated (SO) rats. ABD but not the sham operation caused immediate and significant (P less than .05) increases in mean arterial pressure and heart rate (HR) and an impairment of the baroreflex-mediated control of HR (baroreflex sensitivity, BRS). Two to three days after ABD, these parameters, except the BRS, subsided to near-control levels. Both operations (ABD and sham) significantly reduced the daily water intake but the reduction was significantly greater in ABD rats. Intravenous administration of ethanol (0.1, 0.5 or 1.0 g/kg) to either SO or ABD rats produced short-lived dose-related pressor and bradycardiac responses which correlated well with blood ethanol concentration. In SO rats, ethanol caused dose-related decreases in the slopes of the curves relating increments in mean arterial pressure induced by phenylephrine to corresponding bradycardiac responses; the higher dose significantly (P less than .05) reduced the slope from -2.03 +/- 0.14 to -1.28 +/- 0.18 beats/min/mm Hg, indicating an impairment of BRS. Conversely, in ABD rats, ethanol failed to influence the BRS; the slopes before and after ethanol (1 g/kg) were similar (-1.1 +/- 0.07 vs. -1.0 +/- 0.23 beats/min/mm Hg). The lack of ethanol effect in ABD rats cannot be accounted for by the assumption that aortic barodenervation depressed the baroreceptor reflex to its nadir or by a difference in concentration of blood ethanol.(ABSTRACT TRUNCATED AT 250 WORDS)
el-Mas
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MM
Department of Pharmacology, School of Medicine, East Carolina University, Greenville.
Abdel-Rahman
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AA
D000818:Animals; D001011:Aorta / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects* / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol