Effect of hypolipidemic drugs on cholinesterase activity in the rat.
1. The effect of four hypolipidemic agents with different mechanisms of action (fenofibrate, probucol, colestipol and nicotinic acid) on plasma and liver cholinesterase has been studied. 2. Liver weight and liver weight/body weight ratio increased only after treatment with fenofibrate. 3. Plasma and liver cholinesterase activity increased markedly after fenofibrate, a strong peroxisome proliferator, and slightly after nicotinic acid, a weak peroxisome proliferator. 4. The data obtained suggest that increased cholinesterase activity is due to increased rate of fatty acid oxidation caused by peroxisome proliferators.
Kunec-Vajić
E
E
Department of Pharmacology, Faculty of Medicine, University of Zagreb, Yugoslavia.
Bernat
N
N
Muacević-Katanec
D
D
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002802:Cholinesterases / Q000097:blood / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D000960:Hypolipidemic Agents; D002802:Cholinesterases