Pharmacokinetics of L-671,329 in rhesus monkeys and DBA/2 mice.
The time course of plasma drug levels and urinary recovery for two lipopeptide antifungal antibiotics, L-671,329 and cilofungin, were measured in male rhesus monkeys (Macaca mulatta) and in female DBA/2 mice. The antibiotics were administered intravenously at 10 mg/kg of body weight in phosphate-buffered saline-26% polyethylene glycol for the rhesus monkeys and in 5% dimethyl sulfoxide for the mice. Plasma and urine drug concentrations were determined by high-pressure liquid chromatography and/or a microbiological assay versus Aspergillus niger, and pharmacokinetic parameters were determined for both species. In each of the two rhesus crossover tests as well as in the mouse studies, the pharmacokinetics of the two compounds were similar; however, a marked difference was evident between species. The half-lives of L-671,329 and cilofungin in plasma were 39 and 34 min in the mice and averaged 1.8 and 2 h in the rhesus monkeys, respectively. In mice and rhesus monkeys, urinary recovery was less than 4% for both compounds.
Sundelof
J G
JG
Merck Institute for Therapeutic Research, Rahway, New Jersey 07065.
Hajdu
R
R
Cleare
W J
WJ
Onishi
J
J
Kropp
H
H
D000818:Animals; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D054714:Echinocandins; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D010455:Peptides / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D010456:Peptides, Cyclic / Q000097:blood / Q000493:pharmacokinetics / Q000652:urine; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; C058995:pneumocandin A(0); C042101:cilofungin