[The biphasic response of hepatic arterial blood flow caused by vasoactive substances--an experimental study in dogs].
In ten male mongrel dogs, blood flow was measured in the common hepatic artery (CHA), portal vein (PV) and liver tissue before and after the injection of vasoactive substances: angiotensin II (1.0 micrograms/kg), prostaglandin F2 alpha (1.0 micrograms/kg) and vasopressin (0.1 Unit/kg), under observation of the systemic circulation. Each injection caused a biphasic response in CHA blood flow, an initial decrease followed by a marked increase, while PV blood flow decreased. Liver tissue blood flow was reduced just after injection, but soon returned to a normal level. The duration of action was the shortest with prostaglandin F2 alpha and the longest with vasopressin. In using vasoactive substances in pharmaco-angiography, it is important to consider the biphasic response in CHA blood flow as well as the duration of action of these substances.
Motohashi
O
O
Department of Internal Medicine, Kitasato University School of Medicine.
Saigenji
K
K
Kusano
S
S
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D015237:Dinoprost / Q000494:pharmacology*; D004285:Dogs; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D013268:Stimulation, Chemical; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D000804:Angiotensin II; D015237:Dinoprost