title: Antibiotic prophylaxis following lower urinary tract instrumentation.
abstract: The value of routine antibiotic prophylaxis was assessed in 362 women undergoing lower urinary tract instrumentation. A three-day course of a once-a-day dose of 1 g of cefadroxil was compared with a three-day course of 100 mg of nitrofurantoin three times a day, in a randomized investigator blinded placebo controlled study. Both study drugs were significantly more effective in preventing postinstrumentation urinary tract infections than placebo (p less than 0.003). Differences in efficacy between the two test drugs were not significant; however, side effects in the nitrofurantoin group were more frequent and severe than those in the cefadroxil group. Cefadroxil also offered the advantage of a once-daily dosing schedule.
authors.affiliation: Division of Gynecologic Urology, Harbor-UCLA Medical Center.
authors.forename: N N
authors.initials: NN
authors.lastname: Bhatia
authors.forename: M M
authors.initials: MM
authors.lastname: Karram
authors.forename: A
authors.initials: A
authors.lastname: Bergman
authors.forename: R P
authors.initials: RP
authors.lastname: Evans
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002434:Cefadroxil / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009582:Nitrofurantoin / Q000627:therapeutic use*; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014572:Urology / Q000295:instrumentation*
chemical_list: D000900:Anti-Bacterial Agents; D002434:Cefadroxil; D009582:Nitrofurantoin