title: Adriamycin in hyperthermic perfusion for advanced limb sarcomas.
abstract: From February 1989 to April 1991, 12 hyperthermic limb perfusions (HLP) with adriamycin (ADR) were performed in 12 patients with high grade soft tissue sarcomas (9 in the leg and 3 in the arm); two were at A.J.C. stage IIb, eight stage IIIb and two stage IV. ADR (0.7-1.5 mg/kg) was administered in bolus at a mean temperature of 41.5 degrees C and perfused for 60 min. No systemic toxicity was reported; seven patients had grade II locoregional toxicity, another four grade III and one grade IV. Tumor necrosis (radiological evaluation) was less than 25% in two patients, 25% to 50% in two, 50% to 75% in five and greater than 75% in three. Limb sparing surgery was feasible in ten patients. At present eight patients are alive; three had local recurrence and four distant metastases.
authors.affiliation: Istituto di Patologia Chirurgica I, Università di Padova, Italia.
authors.forename: C R
authors.initials: CR
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Vecchiato
authors.forename: P P
authors.initials: PP
authors.lastname: Da Pian
authors.forename: D
authors.initials: D
authors.lastname: Nitti
authors.forename: M
authors.initials: M
authors.lastname: Lise
authors.forename: P L
authors.initials: PL
authors.lastname: Melanotte
authors.forename: S
authors.initials: S
authors.lastname: Turra
authors.forename: F
authors.initials: F
authors.lastname: Vigliani
mesh_terms: D000328:Adult; D000368:Aged; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D004317:Doxorubicin / Q000008:administration & dosage*; D005121:Extremities; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012509:Sarcoma / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*
chemical_list: D004317:Doxorubicin