Activation of HIV transcription by Tat.
Recent studies suggest that the human immunodeficiency virus transactivator, Tat, increases expression of viral genes primarily by enhancing the efficiency of transcriptional elongation. The degree to which Tat influences elongation may depend on the rate of transcriptional initiation. Current models in which Tat interacts with the transcription complex suggest directions for future studies.
Frankel
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Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.
D001483:Base Sequence; D015696:Gene Products, tat / Q000502:physiology*; D006678:HIV / Q000235:genetics*; D008969:Molecular Sequence Data; D014157:Transcription Factors / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D014157:Transcription Factors; D054322:tat Gene Products, Human Immunodeficiency Virus