Effect of methyl substitution on protein tertiary structure.
Biological effects caused by the post-translational methylation of certain side chains in proteins has been thought to be due solely to changes in charge, steric relations or hydrophobicity at the site of the methyl group. However, there is increasing evidence that the presence of CH3 can also induce a "global" effect on the protein molecule. Some of the evidence is described in this paper.
Paik
W K
WK
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140.
Kim
S
S
D000588:Amines / Q000737:chemistry; D008745:Methylation; D008958:Models, Molecular; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational
D000588:Amines