title: Prostaglandins and teleost neurohypophyseal hormones induce premature parturition in the guppy, Poecilia reticulata.
abstract: Administration of PGE2, PGF2 alpha, isotocin, and vasotocin to pregnant guppies during late gestation induced premature parturition. Indomethacin (10 micrograms/g body wt), the cyclooxygenase inhibitor, did not inhibit parturition at term, suggesting that some lipoxygenase metabolites may be involved in the induction of parturition. Pituitary extract, as well as LH-RH, did not induce premature parturition. It may be that in the guppy, in which ovulation occurs at the end of gestation just prior to parturition, gonadotropin is not involved in the induction of ovulation and parturition.
authors.affiliation: Department of Zoology, National University of Singapore.
authors.forename: B
authors.initials: B
authors.lastname: Venkatesh
authors.forename: C H
authors.initials: CH
authors.lastname: Tan
authors.forename: T J
authors.initials: TJ
authors.lastname: Lam
mesh_terms: D000818:Animals; D015237:Dinoprost / Q000494:pharmacology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D010060:Ovulation / Q000187:drug effects; D010902:Pituitary Gland; D010909:Pituitary Hormones, Posterior / Q000494:pharmacology*; D011036:Poecilia / Q000502:physiology*; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D012098:Reproduction / Q000187:drug effects; D014020:Tissue Extracts / Q000494:pharmacology
chemical_list: D010909:Pituitary Hormones, Posterior; D011453:Prostaglandins; D011458:Prostaglandins E; D014020:Tissue Extracts; D007987:Gonadotropin-Releasing Hormone; D015237:Dinoprost; D007213:Indomethacin