Improvement of nerve conduction in diabetic neuropathy. A follow-up study 4 yr after combined pancreatic and renal transplantation.
Eighteen patients with long-standing insulin-dependent (type 1) diabetes mellitus and polyneuropathy were studied after combined pancreatic and renal transplantation. Repeated tests were performed on peripheral nerve function (electroneurography) and on autonomic function (R-R test) 6 mo and 1, 2, and 4 yr after the transplantation. Eighteen diabetic patients with only a kidney graft served as controls. After initial improvement of nerve conduction in both groups, probably caused by the elimination of uremia, further improvement was seen only in the euglycemic pancreas-graft recipients. Improvement of autonomic (parasympathetic) function was slight after 48 mo and was similar in both groups.
Solders
G
G
Department of Clinical Neurophysiology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
Tydén
G
G
Persson
A
A
Groth
C G
CG
D000328:Adult; D000704:Analysis of Variance; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D003928:Diabetic Nephropathies / Q000601:surgery; D003929:Diabetic Neuropathies / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D016035:Pancreas Transplantation / Q000502:physiology*; D011446:Prospective Studies; D013997:Time Factors