The interaction of motor, memory, and emotional dysfunction in Wilson's disease.
Measures of the degree of motor, psychiatric, and declarative memory disability were made in neurologically impaired and neurologically asymptomatic patients with Wilson's disease. All three types of disability were significantly greater in the neurologically impaired than in the asymptomatic patients. There was no significant interaction between these disabilities in the impaired patients suggesting that motor, psychiatric, and memory symptoms are three relatively independent sequelae of the copper-induced central nervous system (CNS) damage that underlies Wilson's disease.
Medalia
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A
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY.
Galynker
I
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Scheinberg
I H
IH
D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis* / Q000209:etiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D003300:Copper / Q000009:adverse effects; D005260:Female; D006304:Health Status; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008950:MMPI; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology; D009069:Movement Disorders / Q000175:diagnosis* / Q000209:etiology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012720:Severity of Illness Index; D014888:Wechsler Scales
D003300:Copper