title: Life events and relapse in bipolar affective disorder.
abstract: In a 2 year study of life events and relapse in a cohort of 62 patients with bipolar affective disorder, an excess of events was found during the month immediately preceding relapse. Of 52 relapses 19% were preceded by a severe event in the previous month, compared to a background rate of 5% of patients experiencing a severe event each month at other times. The rate of life events prior to relapse was not apparently different between manic and depressive relapse, though the number of depressive episodes was small.
authors.affiliation: Department of Psychological Medicine, Medical College of St Bartholomew's Hospital, West Smithfield, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Hunt
authors.forename: W
authors.initials: W
authors.lastname: Bruce-Jones
authors.forename: T
authors.initials: T
authors.lastname: Silverstone
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy / Q000523:psychology*; D002220:Carbamazepine / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008016:Life Change Events; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors
chemical_list: D000928:Antidepressive Agents; D002220:Carbamazepine; D008094:Lithium