title: Disposition of quinine in plasma, red blood cells and saliva after oral and intravenous administration to healthy adult Africans.
abstract: The pharmacokinetics of quinine has been studied in ten healthy adult Africans after intravenous infusion and oral ingestion of a 500 mg dose. Blood and saliva samples were collected over 48 h and quinine in plasma, red cells and saliva was determined by HPLC. Quinine was rapidly and almost completely absorbed after an oral dose, with absorption half-life of 0.53 h, a tmax of 1-3 h and a bioavailability of 88%. Analysis of the i.v. data gave an apparent volume of distribution of 3.6 l.kg-1 and a plasma clearance of 0.19 l.kg-1.h-1. The concentration-time curves for plasma, red cells and saliva had declining phases were approximately parallel, giving a similar half-life that in all three media. The half-lives after the i.v. infusion also did not different from those after oral administration. The dose was well tolerated by both methods of administration.
authors.affiliation: Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
authors.forename: L A
authors.initials: LA
authors.lastname: Salako
authors.forename: A
authors.initials: A
authors.lastname: Sowunmi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009549:Nigeria; D011803:Quinine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012463:Saliva / Q000378:metabolism*
chemical_list: D011803:Quinine