[The use of bead cellulose for controlled drug liberation. 5. Kinetics of liberation of bonded drugs from bead cellulose and bead cellulose derivatives].
Examination of in vitro liberation of prazosin hydrochloride and benzocaine from formulations of matrix type with bead cellulose and bead cellulose derivatives shows deviations from first order kinetics owing to competition of several processes: dissociation of ionic bonds or cleavage of covalent bonds between drugs and bead cellulose, pore diffusion, dissolution of the drugs and swelling of cellulose matrix. Suitable combinations of different bonded portions of the drug on bead celluloses let these complexes seem to be successful in the use for controlled and retarded liberation of drugs.
Wolf
B
B
Sektion Biowissenschaften, Universität Leipzig-Lehrstuhl Pharmazeutische Technologie.
D002482:Cellulose; D003692:Delayed-Action Preparations; D007700:Kinetics; D008863:Microspheres
D003692:Delayed-Action Preparations; D002482:Cellulose
Einsatz der Perlcellulose zur kontrollierten Arzneistoff-Freigabe. 6. Mitteilung: Kinetik der Freisetzung von gebundenen Arzneistoffen aus Perlcellulosen und Perlcellulose-Derivaten.