[Cell culture and its application proliferative life span and immortalization of cultured human cells].
It known that human diploid cells in culture have a limited proliferative life span (cellular senescence). Recently, evidence has accumulated that known and unknown anti-oncogenes participate in this phenomenon. Deletion or inactivation of these genes resulted in unlimited proliferation (immortalization).
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Department of Cellular and Molecular Biology, Hiroshima University School of Medicine, Japan.
D002453:Cell Cycle / Q000235:genetics / Q000502:physiology; D016923:Cell Death / Q000235:genetics / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000235:genetics / Q000502:physiology; D005347:Fibroblasts / Q000166:cytology; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans