[Prognostic value of local vascular infiltration in infiltrating transitional carcinoma of the bladder].
The present retrospective study analyzes the evolution and survival of 79 patients with bladder infiltrant transitional carcinoma (T2-T3), which were treated with radical cystectomy and bilateral ilio-obturating lymphadenectomy. Pre-operative radiotherapy (57/79) and neo-adjuvant chemotherapy (24/79) was used as supplementary therapy. The univariate analysis showed the relationship between tumour vascular infiltration (TVI) and presence of nodes micrometastasis (p = 0.002). The variables with greater forecast power in the multivariate analysis for survival were a decline in the post-radio and/or neo-adjuvant chemotherapy tumoral stage (p = 0.000) and TVI (p = 0.001). Survival decreased significantly in patients with TVI (p = 0.008), this finding denoting a worse prognosis than the presence of nodular micrometastasis (p = 0.01).
de Castro
F
F
Departamento de Urología, Facultad de Medicina, Universidad de Navarra.
Sánchez
P
P
Robledo
C
C
Rosell
D
D
Agüera
L
L
Isa
W
W
Robles
J E
JE
Zudaire
J J
JJ
Berián
J M
JM
D000206:Actuarial Analysis; D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009360:Neoplastic Cells, Circulating; D011379:Prognosis; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy
Valor pronóstico de la infiltración vascular local en el carcinoma transicional infiltrante de vejiga.