Selectivity of a CaCl2 continuous infusion screening method in rats.
In albino rats the combined use of two methods based on a continuous perfusion of aconitine nitrate (0.15 mg/ml) or calcium chloride (0.4 M) demonstrated the selectivity of the calcium chloride-induced dysrhythmias model. This rapid screening was carried out with antidysrhythmic agents according to the Vaughan-Williams's classification (1): quinidine (class I) 5 mg/kg; atenolol (class II) 2 mg/kg; amiodarone (class III) 10 mg/kg and verapamil (class IV) 2 mg/kg. A compound synthesized in our laboratory was used to verify model selectivity.
Vaille
A
A
Laboratoire de Pharmacodynamie, U.F.R. de Pharmacie de Marseille, France.
Scotto di Tella
A M
AM
Maldonado
J
J
Vanelle
P
P
D000157:Aconitine / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D002122:Calcium Chloride / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects*; D006321:Heart / Q000187:drug effects; D008722:Methods; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000889:Anti-Arrhythmia Agents; D002122:Calcium Chloride; D000157:Aconitine