Identification of oxidatively modified lipids in atherosclerotic lesions of human aortas.
The oxygenated lipids of human aortas with atherosclerotic lesions were analysed by RP-, SP- and Chiral Phase-HPLC and compared with those obtained after treatment of human LDL with pure 15-lipoxygenase (LOX) of rabbit reticulocytes. The data suggest an indirect role of 15-LOX in the atherogenesis in aortas.
Belkner
J
J
Institute of Biochemistry, Medical School, Charité, Humboldt Universitity Berlin, Germany.
Wiesner
R
R
Kühn
H
H
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000097:blood; D008084:Lipoxygenase / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet
D008077:Lipoproteins, LDL; D002784:Cholesterol; D008084:Lipoxygenase