title: C-fos protooncogene expression in rat brain after long-term training of two-way active avoidance reaction.
abstract: C-fos nuclear protooncogene encodes a regulatory protein (Fos), able to directly influence both expression of itself and other genes. It has been repeatedly shown that c-fos expression coincides with different forms of cell activation, probably being functionally involved in the coupling of extracellular ligands to long-term cellular responses. In this study it has been found that c-fos mRNA accumulation in rat brain, as measured by northern blotting coincides with increase of performance level of learned behavior of a two-way active avoidance task. We have previously reported (Nikolaev et al., Brain Res. Bull., in press) that a single training session of two-way active avoidance strongly induces c-fos mRNA accumulation but that after long-term training up to the asymptotic level of performance no c-fos expression was detectable. In this paper we show that c-fos still remains inducible even after long-term, asymptotic training to darkness as conditioned stimulus (CS), provided that a novel stimulus, wide band noise, which elevated performance level, was given together with darkness as compound CS.
authors.affiliation: Department of Neurophysiology, Nencki Institute of Experimental Biology, Warsaw, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Nikolaev
authors.forename: T
authors.initials: T
authors.lastname: Werka
authors.forename: L
authors.initials: L
authors.lastname: Kaczmarek
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D015152:Blotting, Northern; D001921:Brain / Q000502:physiology*; D002467:Cell Nucleus / Q000378:metabolism; D005786:Gene Expression Regulation; D016762:Genes, fos / Q000502:physiology*; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D012333:RNA, Messenger