title: Neurology of otolith function. Peripheral and central disorders.
abstract: The otolith organs detect gravitoinertial forces acting on the head providing signals to the brain which are essential for spatial orientation, sensing motion and organizing motor behaviour. Although the pathophysiology of otolithic dysfunction is poorly understood, a disorder of otolith function, at a peripheral or central level, may be suspected when a patient describes symptoms of false sensations of linear motion or tilt or shows signs of specific derangements of ocular motor and postural, orienting and balancing responses. When disorientation is severe the patient may describe symptoms which sound bizarre, raising doubts over the organic basis of the disease. Our recognition of an otolithic disorder and understanding otolithic involvement in a wider neurological context may be guided by knowledge of otolith physiology and of the characteristics of the few proven otolithic syndromes.
authors.affiliation: MRC Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Gresty
authors.forename: A M
authors.initials: AM
authors.lastname: Bronstein
authors.forename: T
authors.initials: T
authors.lastname: Brandt
authors.forename: M
authors.initials: M
authors.lastname: Dieterich
mesh_terms: D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D001930:Brain Injuries / Q000150:complications; D003937:Diagnosis, Differential; D005133:Eye Movements; D005402:Fistula / Q000209:etiology; D006257:Head / Q000502:physiology; D006801:Humans; D009068:Movement; D009434:Neural Pathways / Q000502:physiology; D009759:Nystagmus, Pathologic / Q000209:etiology / Q000503:physiopathology; D010037:Otolithic Membrane / Q000502:physiology* / Q000503:physiopathology; D004856:Postural Balance; D011187:Posture; D011597:Psychomotor Performance; D014717:Vertigo / Q000209:etiology; D015837:Vestibular Diseases / Q000150:complications / Q000209:etiology / Q000503:physiopathology