title: Experimental evaluation of a collagen-coated vicryl mesh as a dural substitute.
abstract: Dural substitutes must provide immediate restitution of a membranous covering for the brain without inducing any adverse reaction in the host or provoking adhesions to underlying nervous tissues. Ideally, the material should disappear completely and be replaced by tissues similar to the dura mater. In this study, parietal dural defects were created in 12 beagle dogs and closed with a vicryl mesh prosthesis made watertight by a film of bovine collagen. Clinical and biological tolerances were satisfactory. There was one case of early local infection. Gross and microscopic examinations performed between 7 days and 9 months after implantation showed degradation of the prosthetic mesh and connective tissue growth into the implant mimicking dura mater as early as 15 days after implantation. There was no attendant inflammatory reaction or cortical adhesions or other adverse reactions. The authors conclude that collagen-embedded vicryl mesh provides satisfactory biological function and compatibility when used as a substitute for dura mater in the dog.
authors.affiliation: Department of Neurosurgery, Hôpital Pellegrin, Bordeaux, France.
authors.forename: F
authors.initials: F
authors.lastname: San-Galli
authors.forename: V
authors.initials: V
authors.lastname: Darrouzet
authors.forename: J
authors.initials: J
authors.lastname: Rivel
authors.forename: C
authors.initials: C
authors.lastname: Baquey
authors.forename: D
authors.initials: D
authors.lastname: Ducassou
authors.forename: J
authors.initials: J
authors.lastname: Guérin
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen; D004285:Dogs; D004388:Dura Mater / Q000473:pathology / Q000601:surgery; D005549:Foreign-Body Reaction / Q000473:pathology; D011098:Polyglactin 910; D012886:Skull / Q000601:surgery; D013526:Surgical Mesh; D013530:Surgical Wound Infection; D014014:Tissue Adhesives
chemical_list: D001672:Biocompatible Materials; D014014:Tissue Adhesives; D011098:Polyglactin 910; D003094:Collagen