title: Enhanced induction of hepatic lipid peroxidation by ferric nitrilotriacetate in chickens susceptible to fatty liver rupture.
abstract: 1. Two strains of single comb White Leghorn birds, one susceptible to fatty liver rupture (UCD-003) and a normal commercial strain, were injected with iron nitrilotriacetate and the extent of hepatic lipid peroxidation that occurred was estimated by measuring concentrations of malondialdehyde (MDA). 2. Higher concentrations of MDA were found in the livers of the UCD-003 strain than in the normal birds after injection of iron nitrilotriacetate. No differences were found in the activities of glutathione peroxidase, superoxide dismutase and catalase in the livers of untreated birds of either strain. 3. The degree of unsaturation of the fats in the livers of the two strains was similar. However, the UCD-003 birds had a significantly higher content of liver fat than the normal birds. The increased concentrations of liver fat could account for the increased lipid peroxidation in the UCD-003 birds. 4. The increased incidence of liver haemorrhage that occurs in the UCD-003 birds may be caused by the increased susceptibility of these birds to hepatic lipid peroxidation.
authors.affiliation: Department of Animal and Poultry Science, University of Guelph, Ontario, Canada.
authors.forename: E J
authors.initials: EJ
authors.lastname: Squires
authors.forename: J
authors.initials: J
authors.lastname: Wu
mesh_terms: D000818:Animals; D002374:Catalase / Q000032:analysis; D002645:Chickens; D005234:Fatty Liver / Q000378:metabolism / Q000662:veterinary*; D005260:Female; D005290:Ferric Compounds / Q000494:pharmacology; D005979:Glutathione Peroxidase / Q000032:analysis; D015227:Lipid Peroxidation; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008315:Malondialdehyde / Q000032:analysis; D009571:Nitrilotriacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D011201:Poultry Diseases / Q000378:metabolism*; D012422:Rupture, Spontaneous; D013482:Superoxide Dismutase / Q000032:analysis
chemical_list: D005290:Ferric Compounds; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D009571:Nitrilotriacetic Acid; C020326:ferric nitrilotriacetate