Bioassay of interleukin 1 (IL-1) in human gingival crevicular fluid during experimental gingivitis.
The cytokine IL-1 was demonstrated in crevicular fluid during a 14- and 21-day experimental gingivitis in healthy human volunteers. A sensitive and specific bioassay allowed detection of biologically active IL-1 at levels ranging from 0.18 ng/microliters at baseline to 1.70 ng/microliters in inflamed gingiva. Levels of IL-1 increased rapidly with plaque accumulation and in advance of the subsequent gingival inflammation, peaking within 7 days of the start of gingivitis. As changes in IL-1 were detected before clinically recognizable gingival changes, IL-1 may have potential as an early marker of gingival inflammatory changes.
Kinane
D F
DF
Department of Oral Medicine and Pathology, University of Glasgow Dental School, U.K.
Winstanley
F P
FP
Adonogianaki
E
E
Moughal
N A
NA
D000328:Adult; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000276:immunology; D005891:Gingivitis / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008297:Male; D010512:Periodontal Index; D012044:Regression Analysis
D007375:Interleukin-1