[Clinical study of panipenem/betamipron for burn infections in the domain of plastic and reconstructive surgery].
The effectiveness and the safety of panipenem/betamipron, new antibiotics of the carbapenems for burn infections, were studied and the following results were obtained: 1. The preparation, 0.5 g/0.5 g, was administered by intravenous drip infusion twice a day to 11 cases of patients with burn infections. In 10 cases for which clinical effects were evaluable, results were rated as "excellent" in 2 cases, "good" in 2 cases and "fair" in 6 cases, with an efficacy rate of 40%. 2. Penetration to the affected tissue was studied in 2 cases. The tissue level of panipenem was 0.20 micrograms/g immediately after the end of drip infusion and 6.86 micrograms/g 60 minutes thereafter. 3. As for the safety, a slight increase in GOT, GPT and Al-P was noted in 1 case; a slight increase in GPT, NAG and beta 2MG was found in 1 case; and a slight increase in GOT, GPT, Al-P and LAP was noted in 1 case, as abnormal variations in laboratory test results.
Yoshida
T
T
Department of Plastic and Reconstructive Surgery, School of Medicine, Hokkaido University.
Narumi
E
E
Murazumi
M
M
Kamo
R
R
Ohura
T
T
Sakamura
R
R
Iida
K
K
Honda
K
K
Yamamoto
Y
Y
Kimura
C
C
D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D002648:Child; D004341:Drug Evaluation; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012874:Skin Diseases, Infectious / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013518:Surgery, Plastic; D013845:Thienamycins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution; D014946:Wound Infection / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use
D013845:Thienamycins; D015091:beta-Alanine; C075316:panipenem-betamipron