Trimethoprim-sulfamethoxasole induced meningitis in systemic lupus erythematosus.
Most reports of drug induced meningitis in systemic lupus erythematosus (SLE) have implicated ibuprofen. We describe a 46-year-old woman with SLE who developed aseptic meningitis abruptly after ingesting trimethoprim-sulfamethoxasole (TMP-SMX). This patient had received TMP-SMX twice before; each was associated with increasingly severe reactions, whose relationship with the use of TMP-SMX became apparent only in retrospect. A history of medication use should be sought in all patients with meningitis who have an underlying autoimmune disorder.
Escalante
A
A
Arthritis Service, Rancho Los Amigos Medical Center, Downey, CA.
Stimmler
M M
MM
D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008582:Meningitis, Aseptic / Q000139:chemically induced* / Q000209:etiology; D008875:Middle Aged; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy
D015662:Trimethoprim, Sulfamethoxazole Drug Combination