In vivo and in vitro productions of interleukin-2, interleukin-2 receptor and gamma-interferon in multitransfused thalassemic patients.
In vivo and in vitro productions of interleukin-2 (IL-2), IL-2 receptor (IL-2R) and gamma-interferon (gamma-IFN) in 64 multi-transfused thalassemic patients and 20 healthy children were studied. The results were: 1) Increased serum concentrations of IL-2 and IL-2R, and decreased serum concentration of gamma-IFN were found in thalassemic patients when compared to controls. 2) In in vitro study, productions of IL-2, IL-2R and gamma-IFN were much lower in thalassemic patients than in controls. The possible mechanisms for the altered lymphokine productions are discussed.
Hwang
K C
KC
Department of Pediatrics, Provincial Tao-Yuan General Hospital, Taiwan, R.O.C.
Hsieh
K H
KH
Chen
B W
BW
Lin
K H
KH
D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis*; D013789:Thalassemia / Q000276:immunology* / Q000628:therapy
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D007371:Interferon-gamma