Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP).
In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition--without the need for reinfusion of the shed blood--starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.
Guarini
S
S
Institute of Pharmacology, University of Modena, Italy.
Bazzani
C
C
Tagliavini
S
S
Bertolini
A
A
Ferrari
W
W
D000818:Animals; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D012771:Shock, Hemorrhagic / Q000188:drug therapy*
D004246:Dimethylphenylpiperazinium Iodide