[Primary arterial hypertension. Treatment with captopril and function of the left heart ventricle, concentration of catecholamine in blood and activity of renin].
We evaluated the effect of captopril treatment on left ventricular mass (LVM) and function in sustained mild-to-moderate primary hypertension. In 16 men aged 34.5 +/- 6.4 yrs. M-mode echo and pulsed wave Doppler recordings were obtained prior to and after 2 months captopril treatment (50-150 mg daily). No significant changes in heart rate, systolic blood pressure, ejection fraction, fractional shortening, cardiac output, LVM and Doppler-derived indices of mitral inflow were observed. Diastolic blood pressure measured during examination fell from 102.2 +/- 13.3 to 90.3 +/- 9 mmHg (p less than 0.026). No consistent correlations between catecholamines and indexes of left ventricular function were found. Two-month captopril therapy in mild-to-moderate hypertension results in diastolic blood pressure lowering with no effect on LVM or left ventricular function.
Kuch-Wocial
A
A
Kliniki Nadciśnienia Tetniczego i Chorób Naczyń Instytutu Chorób Wewnetrznych Akademii Medycznej, Warszawie.
Miśkiewicz
Z
Z
Pasierski
T
T
Lapiński
M
M
Januszewicz
A
A
Stepniakowski
K
K
Chodakowska
J
J
Januszewicz
W
W
Wocial
B
B
Dabrowska
B
B
D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D002395:Catecholamines / Q000097:blood*; D015150:Echocardiography, Doppler; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D012083:Renin / Q000378:metabolism*; D016277:Ventricular Function, Left / Q000187:drug effects*
D002395:Catecholamines; D002216:Captopril; D012083:Renin
Pierwotne nadcśnienie tetnicze. leczenie kaptoprylem a czynność lewej komory serca, stezenie katecholamin we krwi i aktywność reniny.