Preliminary evaluation of HER-2/neu oncogene and epidermal growth factor receptor expression in normal and neoplastic human ovaries.
The HER-2/neu oncogene (a member of the Erb-like oncogene family) is distinct from but closely related to the c-erb B gene which encodes the epidermal growth factor receptor (EGFr). HER-2/neu gene amplification was found in a large number of mammary carcinomas and there was a strong correlation between this phenomenon and poor prognosis. In our study HER-2/neu oncogene expression was determined in 16 malignant ovarian tumors, 2 ovarian lymphomas and 5 normal ovaries. The HER-2/neu gene was found both in normal ovaries and malignant tumors, without any apparent difference among the various histological types. In all the specimens examined, HER-2/neu expression did not seem to be related to EGF binding capacity.
Mileo
A M
AM
Regina Elena Institute for Cancer Research, Roma, Italy.
Fanuele
M
M
Battaglia
F
F
Scambia
G
G
Benedetti-Panici
C
C
Mattei
E
E
Mancuso
S
S
Delpino
A
A
D066246:ErbB Receptors / Q000032:analysis* / Q000235:genetics; D005260:Female; D005784:Gene Amplification / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D009857:Oncogenes / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D010053:Ovary / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis
D012333:RNA, Messenger; D012334:RNA, Neoplasm; D066246:ErbB Receptors