Confirmation of the influence of a chromosome 7 locus on susceptibility to audiogenic seizures.
Mouse strain differences in susceptibility to audiogenic seizures (AGS) are due to allelic differences at multiple genetic loci. Three loci that influence susceptibility to AGS have been mapped on Chromosomes (Chr) 12, 4, and 7 (Asp-1, Asp-2, and Asp-3, respectively). Here we report evidence that confirms linkage of Asp-3 to c on Chr 7 and parental effects on AGS susceptibility, but not genomic imprinting of Asp-3.
Neumann
P E
PE
Department of Neurology, Children's Hospital, Boston, Massachusetts 02115.
Collins
R L
RL
D000161:Acoustic Stimulation; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D003433:Crosses, Genetic; D005260:Female; D020022:Genetic Predisposition to Disease; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008811:Mice, Inbred DBA; D012640:Seizures / Q000235:genetics*