title: [MR imaging of amyotrophic lateral sclerosis].
abstract: Magnetic resonance imaging (MR imaging) provides a sensitive method for mapping the normal and pathological distribution of iron in the brain. High field strength MR imaging (1.5 T) was used to evaluate eight patients with amyotrophic lateral sclerosis (ALS) and 49 neurological normal control patients. All eight ALS patients showed decreased signal intensity in the motor cortex on T2-weighted images, while only one of the normal control patients showed this finding. The results suggested that the decreased signal intensity in the motor cortex in ALS was caused by the deposition of iron in this area.
authors.affiliation: Department of Radiology, University Hospital of Yamanashi.
authors.forename: H
authors.initials: H
authors.lastname: Oba
authors.forename: T
authors.initials: T
authors.lastname: Araki
authors.forename: S
authors.initials: S
authors.lastname: Monzawa
authors.forename: H
authors.initials: H
authors.lastname: Onishi
authors.forename: K
authors.initials: K
authors.lastname: Toyama
authors.forename: K
authors.initials: K
authors.lastname: Kachi
authors.forename: Y
authors.initials: Y
authors.lastname: Nogata
authors.forename: K
authors.initials: K
authors.lastname: Ohtomo
authors.forename: K
authors.initials: K
authors.lastname: Koizumi
authors.forename: G
authors.initials: G
authors.lastname: Uchiyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000378:metabolism*
chemical_list: D007501:Iron