title: Growth inhibitory and differentiating effects of sodium butyrate on human neuroblastoma cells in culture.
abstract: The effect of sodium butyrate (NaB) on cell growth and expression of morphological and biochemical properties was examined in the human neuroblastoma cell lines AF8 and SJ-N-KP. The obtained data show that NaB induced a marked growth inhibition and morphological differentiation, while it was ineffective in inducing biochemical differentiation.
authors.affiliation: Istituto di Cancerologia, Università di Bologna, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Rocchi
authors.forename: A M
authors.initials: AM
authors.lastname: Ferreri
authors.forename: G
authors.initials: G
authors.lastname: Simone
authors.forename: D
authors.initials: D
authors.lastname: Granchi
authors.forename: P
authors.initials: P
authors.lastname: Paolucci
authors.forename: G
authors.initials: G
authors.lastname: Paolucci
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000911:Antibodies, Monoclonal; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D009447:Neuroblastoma; D016900:Neurofilament Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D002087:Butyrates; D053379:Chromogranin A; D002864:Chromogranins; D006680:HLA Antigens; D006684:HLA-DR Antigens; D016900:Neurofilament Proteins; D016708:Synaptophysin; D020148:Butyric Acid; D000110:Acetylcholinesterase; D010751:Phosphopyruvate Hydratase