title: nov: a new genetic locus that affects the response of Escherichia coli K-12 to novobiocin.
abstract: We have identified a new gene locus (nov) affecting the resistance of Escherichia coli K-12 to novobiocin. The gene also affects, although to a lesser extent, tolerance to another gyrase inhibitor coumermycin. Transductional and complementation analysis show that nov is located between att phi 80 and the osmZ (hns) genes at minute 27 of the E. coli K-12 genetic map. In standard laboratory strains of E. coli K-12 nov exists at least in two allelic forms.
authors.affiliation: Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia.
authors.forename: J
authors.initials: J
authors.lastname: Rakonjac
authors.forename: M
authors.initials: M
authors.lastname: Milic
authors.forename: D
authors.initials: D
authors.lastname: Ajdic-Predic
authors.forename: D
authors.initials: D
authors.lastname: Santos
authors.forename: R
authors.initials: R
authors.lastname: Ivanisevic
authors.forename: D J
authors.initials: DJ
authors.lastname: Savic
mesh_terms: D000483:Alleles; D049933:Aminocoumarins; D001692:Biological Transport / Q000235:genetics; D002463:Cell Membrane Permeability / Q000235:genetics; D002874:Chromosome Mapping; D003374:Coumarins / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D004278:DNA, Superhelical / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics* / Q000502:physiology; D016153:Genes, Suppressor / Q000502:physiology; D009154:Mutation; D009675:Novobiocin / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D049933:Aminocoumarins; D003374:Coumarins; D004269:DNA, Bacterial; D004278:DNA, Superhelical; D009675:Novobiocin; C004628:coumermycin