title: Histomorphological and cytochemical changes induced in the liver of goldfish Carassius carassius var. auratus by short-term exposure to lead.
abstract: The cellular and molecular effects of experimental lead intoxication (5 mg l-1/24 h and 48 h) were studied in hepatocytes of Carassius carassius var. auratus. Significant lead storage was not detected by atomic absorbance spectroscopy after treatment. Cell morphology appeared only poorly impaired. A decrease of glycogen content was observed. Glycolysis, Krebs cycle and pentose shunt were altered in their enzymatic activities. Lysosomal activities were strongly increased. All enzymatic activities tested were altered 24 h after lead treatment.
authors.affiliation: Department of Animal Biology, University of Modena, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Fantin
authors.forename: A
authors.initials: A
authors.lastname: Franchini
authors.forename: P
authors.initials: P
authors.lastname: Trevisan
authors.forename: A
authors.initials: A
authors.lastname: Pederzoli
mesh_terms: D000818:Animals; D004798:Enzymes / Q000032:analysis; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006054:Goldfish; D006651:Histocytochemistry; D007854:Lead / Q000633:toxicity; D007855:Lead Poisoning / Q000473:pathology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008297:Male; D010427:Pentose Phosphate Pathway / Q000187:drug effects
chemical_list: D004798:Enzymes; D007854:Lead