[Evaluation of the effectiveness of prostacyclin in the treatment of thrombosis of the central retinal vein using a double-blind method].
The patients were divided by chance into 2 groups: the first one (15 persons) was given a natrium salt of prostacyclin (Epoprostenol Wellcome or Chinoin) in a dose of 5 mg/kg/min. intravenously by an infusion pump in 5 infusions; the control group (15 persons) received instead of prostacyclin a placebo (0.1 M glycine buffer of pH 10.5). Besides all the patients were given Doxium or Calcium dobesilate, Rutinoscorbin, Vitamin C, and Polopyrin S (Soluble Aspirin). Immediately after the completion of the treatment the authors did not find any essential differences between the examined groups. In prolonged observations however one demonstrated a significantly smaller frequency of the development of neovascularization in the eyes of persons treated by prostacyclin in comparison with the control group.
Zygulska-Mach
H
H
Kliniki Okulistycznej AM w Krakowie.
Mirkiewicz-Sieradzka
B
B
Kostka-Trabka
E
E
Grodzińska
L L
LL
Dembińska-Kieć
A D
AD
Romanowska
B
B
Bieroń
K
K
Kedzior
A
A
Basista
M M
MM
D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D011464:Epoprostenol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012170:Retinal Vein Occlusion / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D014792:Visual Acuity / Q000187:drug effects / Q000502:physiology
D010919:Placebos; D011464:Epoprostenol
Ocena skuteczności prostacykliny w leczeniu niedrozności zyły środkowej siatkówki z zastosowaniem metody podwójnie ślepej próby.