Isolation, NMR studies, and biological activities of onopordopicrin from Centaurea sonchifolia.
A sesquiterpene lactone, onopordopicrin [1], has been isolated from Centaurea sonchifolia. Its structure was established by 2D nmr (1H-1H and 13C-1H correlations), and the conformation in CHCl3 was examined by nOe studies. Cytotoxic, antibacterial, and antifungal activities are reported.
Lonergan
G
G
Department of Chemistry, University of New Brunswick, Fredericton, Canada.
Routsi
E
E
Georgiadis
T
T
Agelis
G
G
Hondrelis
J
J
Matsoukas
J
J
Larsen
L K
LK
Caplan
F R
FR
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001266:Atlantic Islands; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007783:Lactones / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; C075494:onopordopicrin