title: Nonlinear pressure/volume relationship and measurements of lung mechanics in infants.
abstract: We examined the effects of within-breath changes in compliance (C) upon the accuracy of measurements of compliance and resistance (R) by linear regression analysis and by Mead and Wittenberger's method. These effects were illustrated by a computer model and by lung models with linear and nonlinear pressure/volume relationships, and were also studied in 14 normal spontaneously breathing premature infants (mean +/- SD, BW 1,290 +/- 200 g, GA 29.9 +/- 2.7 weeks, age 7.4 +/- 2.1 days). Flow was measured by pneumotachography and tidal volume was derived as digitally integrated flow, and transpulmonary pressure as airway minus esophageal pressure. We found that C and R calculated from the equation of motion is accurate only if C and R remain constant throughout the respiratory cycle. Calculated compliance depends more on C at the end than at the beginning of inspiration. A decreasing C leads to underestimation or R, while an increasing C leads to an overestimation of inspiratory R. Calculated total R may be accurate, but with low r values for measurement points. Mead and Wittenberger's method and the regression method are similarly affected by changing C; however, since the regression method is based on many more measurement points and therefore allows the detection and analysis of within-breath changes of C and R, it is less prone to erroneous results secondary to signal artifacts than Mead and Wittenberger's method.
authors.affiliation: Department of Pediatrics, School of Medicine, University of Miami, Florida.
authors.forename: G
authors.initials: G
authors.lastname: Silva Neto
authors.forename: T
authors.initials: T
authors.lastname: Gerhardt
authors.forename: A
authors.initials: A
authors.lastname: Silberberg
authors.forename: T
authors.initials: T
authors.lastname: Gerhardt
authors.forename: N
authors.initials: N
authors.lastname: Claure
authors.forename: S
authors.initials: S
authors.lastname: Duara
authors.forename: E
authors.initials: E
authors.lastname: Bancalari
mesh_terms: D000403:Airway Resistance / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D016014:Linear Models; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance / Q000502:physiology*; D008954:Models, Biological; D011312:Pressure; D012123:Pulmonary Ventilation; D013990:Tidal Volume