Lung diseases associated with digital clubbing.
Clubbing is classified into conditions in which it is commonly, occasionally, rarely and never observed. Hypertrophic osteoarthropathy may be a more extreme form of clubbing, but is more likely to be a related but nevertheless qualitatively different phenomenon. Megakaryocytes or platelet clumps impacting in a digital stratum are plausible causes of clubbing, through the local release of platelet-derived growth factor (PDGF).
Dickinson
C J
CJ
Dunn Laboratory, Department of Medicine, St. Bartholomew's Hospital, West Smithfield, London, U.K.
D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000150:complications* / Q000209:etiology