title: Very-low-calorie-diet therapy in severe obesity.
abstract: This study investigated the effects of very-low-calorie-diet (VLCD) therapy on body weight, plasma glucose, and lipid metabolism in severely obese patients. Ninety-one patients were subjected to VLCD therapy for 4-24 wk. Reduction of body weight was remarkable during the first 4 wk, then leveled off despite continuous treatment. Fasting plasma glucose, triglyceride, and 75-g oral glucose-tolerance test showed a significant improvement. Total cholesterol fell in the early stages but then increased more than the pretreatment level during VLCD. VLCD therapy is useful for the treatment of severe obesity.
authors.affiliation: Third Department of Internal Medicine, Yokohama City University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Okamoto
authors.forename: A
authors.initials: A
authors.lastname: Okamura
authors.forename: Y
authors.initials: Y
authors.lastname: Takamura
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000178:diet therapy*; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol