AML with unusual chromosomal changes. Translocation (15;21) and 5q- in the presence of two normal chromosomes 5.
We performed serial cytogenetic studies of the bone marrow (BM) of a patient with acute myeloblastic leukemia (AML) and noted abnormal karyotypes 47,XY,+del(5)(q12q34),t(15;21)(q21;q22)/47,XY,+del(5)(q12q34 ) during the second relapse. Although a case of this t(15;21) was recently observed in a female patient with acute nonlymphocytic leukemia (ANLL) of subtype M4 of the French-American-British (FAB) classification, the present article constitutes the first report of its occurrence in association with ANLL of subtype M1-M2. Furthermore, the presence of the 5q- accompanied by two chromosomes 5 of normal appearance is very rare and of great interest.
Carrasco Juan
J L
JL
Cytogenetics Service, Faculty of Medicine, University of La Laguna, Canary Islands, Spain.
Otero Gómez
A
A
Garcia Miranda
J L
JL
Brito Barroso
M L
ML
Hernández García
M T
MT
Hernández Nieto
L
L
D000328:Adult; D002884:Chromosomes, Human, Pair 15; D002891:Chromosomes, Human, Pair 21; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*