Evidence for a pseudoautosomal locus for schizophrenia. I: A replication study using phenotype analysis.
A locus for schizophrenia within the pseudoautosomal region of chromosomes X and Y has been suggested by Crow on the basis of epidemiological data. The present report replicates this finding in a sample of 38 French multiply affected families with schizophrenia. Sibship and pairwise analysis, with or without weighted-pair correction, with three different systems of family classifications, showed there to be an excess of same-sex pairs in paternally derived sibships, as predicted by the pseudoautosomal hypothesis.
Gorwood
P
P
Laboratoire de'anthropologie biologique, INSERM V ISS, Université Paris VII, France.
Leboyer
M
M
d'Amato
T
T
Jay
M
M
Campion
D
D
Hillaire
D
D
Mallet
J
J
Feingold
J
J
D005260:Female; D006801:Humans; D008297:Male; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics*; D012737:Sex Factors