Multiple space-occupying lesions of the spleen in a case of Gaucher's disease.
A 50-year-old female patient was admitted because of an enormously enlarged spleen and thrombocytopenia. Ultrasonography and magnetic resonance imaging revealed multiple space-occupying lesions in the spleen. She was diagnosed as having Gaucher's disease based on the low level of beta-glucosidase activity in leukocytes and Gaucher's cells present in bone marrow aspirate. Severe hypersplenism necessitated splenectomy. Pathological studies of the excised spleen, including ultrastructural examinations, demonstrated that multiple space-occupying lesions in the spleen were composed of typical Gaucher cells.
Iwanami
S
S
Second Department of Internal Medicine, Sanraku Hospital, Tokyo, Japan.
Namba
K
K
Tsukada
T
T
Hosaka
T
T
Tagami
M
M
Kubota
A
A
Terada
T
T
D005260:Female; D005776:Gaucher Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013154:Spleen / Q000473:pathology*; D014463:Ultrasonography