title: Multiple unrelated chromosome abnormalities in a metastatic mucoepidermoid carcinoma of the parotid gland.
abstract: We describe cytogenetic findings in a poorly differentiated, metastatic mucoepidermoid carcinoma of the parotid gland. The tumor was characterized by multiple, unrelated chromosome abnormalities. Except for two small aberrant clones showing t(1;7) and t(2;15), respectively, all other abnormal cells showed unique, mostly structural rearrangements peculiar to each cell. No less than 34 different abnormal karyotypes were observed. A similar karyotypic heterogeneity was also described recently in squamous cell carcinomas of the head and neck.
authors.affiliation: Department of Oral Pathology, University of Göteborg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Nordkvist
authors.forename: S
authors.initials: S
authors.lastname: Edström
authors.forename: J
authors.initials: J
authors.lastname: Mark
authors.forename: G
authors.initials: G
authors.lastname: Stenman
mesh_terms: D002277:Carcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000235:genetics*