Effects of fenfluramine and para-chloroamphetamine on sexual behavior of male rats.
The present studies have evaluated the effects of pharmacologically induced release serotonin on sexual responses of male rats during exposure to a sexually receptive female rat. Following acute administration of fenfluramine or para-chloroamphetamine (PCA), significant dose-related decreases in copulatory rate and copulatory efficiency, and increases in ejaculatory latency were observed. These effects were not observed when the animals were pretreated with LY53857, a 5-HT1c/2 antagonist. These studies indicate that acute release of serotonin evoked by these releasing agents has inhibitory effects on sexual sexual drive, capacity to achieve erection and threshold for ejaculation, and these effects are mediated by either the 5-HT1c or 5-HT2 receptor.
Foreman
M M
MM
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.
Hall
J L
JL
Love
R L
RL
D000818:Animals; D003307:Copulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects; D004873:Ergolines / Q000494:pharmacology; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D004873:Ergolines; D012702:Serotonin Antagonists; D005277:Fenfluramine; D010133:p-Chloroamphetamine; C032663:LY 53857