MR diffusion imaging of cerebral infarction in humans.
OBJECTIVE
MR diffusion imaging was performed to investigate changes in water diffusion in patients with cerebral infarction.


METHODS
Diffusion maps of the apparent diffusion coefficient (ADC) were created to show local water mobility in the brain tissue in 15 patients. These ADC maps were compared with conventional T2-weighted images.


RESULTS
Distinct subregions with different water diffusions were detected, even when the infarcted area appeared homogeneous on a T2-weighted image. The results also show that stroke lesions of the same age can have very different water diffusions. A trend towards an increasing diffusion coefficient in a lesion during the first several days following an acute event was observed in a group of patients imaged at multiple timepoints.


CONCLUSIONS
The measurement of diffusion coefficients in vivo now offers an opportunity for greater understanding of the biophysical changes that occur during the evolution of infarction in humans.
Chien
D
D
VA Medical Center, San Francisco, CA.
Kwong
K K
KK
Gress
D R
DR
Buonanno
F S
FS
Buxton
R B
RB
Rosen
B R
BR
D000328:Adult; D000368:Aged; D001834:Body Water / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism*; D004058:Diffusion; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D010865:Pilot Projects