Prolactin similar to ectopic pituitary isograft restores responsiveness in Snell dwarf mice.
The effects of ovine prolactin (PRL) (2 x 5 IU a day) and an ectopic pituitary isograft on the responsiveness were examined using locomotor and exploratory activities as measures in PRL-growth-hormone-thyrotropin-deficient Snell dwarf mice (dw/dw). After 5 weeks of treatment, both PRL and the graft restored the two behavioural measures to normal levels. Results clearly demonstrate the involvement of PRL in global behavioural responsiveness and suggest a possible role for PRL in the changes induced by the graft.
Bouchon
R
R
Laboratoire de Psychophysiologie, URA-CNRS, Université Louis Pasteur, Strasbourg, France.
Griebel
G
G
Vogel
E
E
Misslin
R
R
Ropartz
P
P
D000818:Animals; D001835:Body Weight / Q000502:physiology; D004393:Dwarfism, Pituitary / Q000235:genetics*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000502:physiology*; D010902:Pituitary Gland / Q000637:transplantation*; D011388:Prolactin / Q000502:physiology*; D016042:Transplantation, Heterotopic / Q000502:physiology*; D014185:Transplantation, Isogeneic
D011388:Prolactin