Serotonergic inhibition of limbic and thalamic seizures in cats.
To clarify the role of the serotonergic system in limbic and thalamic epileptic activity, we examined the effects of 5-hydroxytryptophan (5-HTP, 20 and 40 mg/kg) on fully kindled seizures from the hippocampus and lateral geniculate nucleus. The intraperitoneal administration of 20 mg/kg 5-HTP exerted no anticonvulsant effect on hippocampal kindled seizures, and a higher dose (40 mg/kg) produced a significant reduction in the behavioral seizure stage. 5-HTP at 20 mg/kg displayed no suppressive effect on lateral geniculate seizures, and 5-HTP at 40 mg/kg significantly reduced both the seizure stage and afterdischarge duration. Our data suggest that serotonergic mechanisms play an inhibitory role in seizures kindled from these brain regions.
Wada
Y
Y
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Hasegawa
H
H
Nakamura
M
M
Yamaguchi
N
N
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D002415:Cats; D004569:Electroencephalography; D005260:Female; D005829:Geniculate Bodies; D006624:Hippocampus / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects; D008032:Limbic System / Q000503:physiopathology*; D008297:Male; D012640:Seizures / Q000503:physiopathology*; D012701:Serotonin / Q000502:physiology*; D013788:Thalamus / Q000503:physiopathology*
D012701:Serotonin; D006916:5-Hydroxytryptophan