title: Inversion (X)(p22q13) in a uterine leiomyoma.
abstract: We report a case of uterine leiomyoma which showed a karyotype 46,X,inv(X)(p22q13) as the only clonal change in most of the cells. A few cells had an additional del(7), though del(7) has been found to be a primary change in leiomyomas. These findings indicate that the abnormality involving the X chromosome and particularly Xp22 can be considered as a primary chromosomal abnormality. We discuss the findings together with few reports of cases involving chromosome X in leiomyomas.
authors.affiliation: Cancer Center, Southwest Biomedical Research Institute, Scottsdale, Arizona.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Ozisik
authors.forename: A M
authors.initials: AM
authors.lastname: Meloni
authors.forename: U
authors.initials: U
authors.lastname: Surti
authors.forename: J
authors.initials: J
authors.lastname: Davare
authors.forename: A A
authors.initials: AA
authors.lastname: Sandberg
mesh_terms: D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000235:genetics*; D014960:X Chromosome