The effect of physostigmine on the haemorrhagic hypovolemia in anaesthetized rabbits.
1. The effects of physostigmine (70 micrograms kg-1, intravenously) on mean arterial blood pressure, blood volume and survival were studied in anaesthetized rabbits subjected to haemorrhagic hypovolemia. 2. It was found that physostigmine increased the mean arterial blood pressure, increased the residual blood volume, decreased the haematocrit values and increased the survival of the animals. 3. The increase of blood pressure might be due to a general adrenergic activation produced by physostigmine, whereas the increase in plasma volume might be due to changes in pre- to postcapillary resistance ratio. 4. The beneficial effect of physostigmine might also be due to antagonism of humoral factors known to aggravate the hypovolemia (e.g. endogenous opioids).
Savić
J
J
Institute for Medical Research, Military Medical Academy, Belgrade, Yugoslavia.
Varagić
V M
VM
Prostran
M S
MS
Vujnov
S
S
Mihajlović
M
M
Djurdjević
D
D
D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006438:Hemodilution; D006470:Hemorrhage / Q000503:physiopathology; D010830:Physostigmine / Q000494:pharmacology*; D011817:Rabbits; D012769:Shock / Q000503:physiopathology*
D010830:Physostigmine