title: Treatment resistant depression in the elderly: three cases.
abstract: We report three cases of severe depression in whom ECT was relatively contraindicated, who responded dramatically to switching lithium and fluoxetine to lithium and lofepramine. Possible mechanisms are discussed.
authors.affiliation: Rosemary Day Hospital, St. James's University Hospital, Leeds, UK.
authors.forename: J
authors.initials: J
authors.lastname: Seymour
authors.forename: J P
authors.initials: JP
authors.lastname: Wattis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003866:Depressive Disorder / Q000188:drug therapy*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008127:Lofepramine / Q000627:therapeutic use*; D008297:Male
chemical_list: D005473:Fluoxetine; D008094:Lithium; D008127:Lofepramine