title: Antiatherosclerotic properties of oral cicaprost in hypercholesterolemic rabbits.
abstract: The effects of the orally active prostacyclin mimetic cicaprost on morphologic and functional alterations of rabbit aorta was investigated in experimental hypercholesterolemia. Oral cicaprost resulted in a significantly reduced aortic atheromatous plaque formation and partially prevented hypercholesterolemia-induced impairment of endothelium-dependent relaxations. It is concluded that long-term substitution with PGI2 may beneficially influence the progression of atherosclerosis.
authors.affiliation: Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, FRG.
authors.forename: M
authors.initials: M
authors.lastname: Braun
authors.forename: M
authors.initials: M
authors.lastname: Sarbia
authors.forename: P
authors.initials: P
authors.lastname: Kienbaum
authors.forename: T
authors.initials: T
authors.lastname: Hohlfeld
authors.forename: A
authors.initials: A
authors.lastname: Weber
authors.forename: K
authors.initials: K
authors.lastname: Schrör
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001013:Aorta, Thoracic / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D001808:Blood Vessels / Q000473:pathology / Q000503:physiopathology; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000150:complications*; D008055:Lipids / Q000097:blood; D009126:Muscle Relaxation / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D011817:Rabbits
chemical_list: D008055:Lipids; D011464:Epoprostenol; C043867:cicaprost