Inhibition of transketolase and pyruvate decarboxylase by omeprazole.
Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes. Inhibition of PDC was competitive with the coenzyme with a Ki value of 42 +/- 3 microM, whereas inhibition of TK was complex.
Nixon
P F
PF
Department of Biochemistry, University of Queensland, St. Lucia, Australia.
Diefenbach
R J
RJ
Duggleby
R G
RG
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D009853:Omeprazole / Q000494:pharmacology*; D011767:Pyruvate Decarboxylase / Q000037:antagonists & inhibitors*; D013831:Thiamine / Q000494:pharmacology; D014174:Transketolase / Q000037:antagonists & inhibitors*
D014174:Transketolase; D011767:Pyruvate Decarboxylase; D009853:Omeprazole; D013831:Thiamine