Synthesis and antitumour activity of derivatives of curdlan and lichenan branched at C-6.
Derivatives of curdlan and lichenan, linear (1----3)-beta-D- and (1----3/1----4)-beta-D-glucans, respectively, have been synthesised having alpha-L-arabinofuranosyl, alpha-L-rhamnosyl, beta-D-glucosyl, and beta-gentiobiosyl side chains attached at positions 6. These water-soluble derivatives, obtained by condensation of the 2,4- and 2,4-/2,3-di-O-phenylcarbamoyl derivatives of curdlan and lichenan, respectively, with appropriate ortho esters followed by saponification, were characterised by methylation analysis, g.p.c., and interaction with Congo Red. The curdlan derivatives and the lichenan derivative with few glucosyl branches were active against the Sarcoma 180.
Demleitner
S
S
Institut für Pharmazie, Universität Regensburg, Germany.
Kraus
J
J
Franz
G
G
D000818:Animals; D000970:Antineoplastic Agents; D005260:Female; D005936:Glucans / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy*; D047071:beta-Glucans
D000970:Antineoplastic Agents; D005936:Glucans; D047071:beta-Glucans; C038459:curdlan; C015968:lichenin