An enhanced murine model for studies of Serpulina (Treponema) hyodysenteriae pathogenesis.
A defined diet was used to increase the susceptibility of mice to Serpulina hyodysenteriae. BALB/cByJ, C3H/HeN, and C3H/HeJ mice, when fed the defined diet 7 to 14 days prior to and throughout the challenge period, consistently showed higher incidences of disease than mice maintained on normal rodent chow. The use of this defined diet will increase the consistency of in vivo studies following infection with S. hyodysenteriae in the mouse model.
Nibbelink
S K
SK
Department of Microbiology, Immunology, and Preventive Medicine, Iowa State University, Ames 50011.
Wannemuehler
M J
MJ
D000818:Animals; D004032:Diet; D004195:Disease Models, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D014211:Treponemal Infections / Q000209:etiology*