title: [Relationships between manufacturing parameters and pharmaceutical-technological requirements of biodegradable microparticles. 2. Preparation of injectable microparticles in biodegradable polyester].
abstract: Local anesthetics containing biodegradable polyester microparticles are prepared using a modified solvent-evaporation process and a spray drying technique. The preparation methods are compared critically. The modified solvent-evaporation process is preferred for the preparation of microparticles. Yields of 90% and microparticle size distributions can be influenced in a reproducible manner. Using the spray drying technique yields are only 60%. The product is characterized by a high portion of microparticles under 10 microns, which are responsible for the rapid release of cinchocain in 168 h as well.
authors.affiliation: Institut für Pharmazie und Lebensmittelchemie, Ludwig-Maximillians-Universität, München.
authors.forename: K
authors.initials: K
authors.lastname: Thoma
authors.forename: B
authors.initials: B
authors.lastname: Schlütermann
mesh_terms: D000779:Anesthetics, Local; D001673:Biodegradation, Environmental; D002849:Chromatography, Gas; D004339:Drug Compounding; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical
chemical_list: D000779:Anesthetics, Local; D011091:Polyesters
vernacular_title: Beziehungen zwischen Herstellungsparametern und pharmazeutisch-technologischen Anforderungen an biodegradierbare Mikropartikeln. 2. Mitteilung: Verarbeitung biodegradierbarer Polyester zu injizierbaren Mikropartikeln.