Cardiovascular sensitivity changes to eicosanoids in rats with experimentally induced diabetes mellitus.
This paper attempts to provide a short review of the evidence for: 1. Increased platelet production of thromboxane A2 and reduced vascular production of prostacyclin in the human and also animal models of diabetes. 2. Reduced depressor responsiveness to arachidonic acid of anaesthetized alloxan- and streptozotocin-induced diabetic rats. 3. Enhanced constrictor responsiveness to arachidonic acid in blood-perfused hindquarters of alloxan-induced diabetic rats. 4. Potentiation by the thromboxane A2-mimetic, U46619, of constrictor responses to 5-hydroxytryptamine in Krebs'-perfused hindquarters and kidneys of both control and alloxan-induced diabetic rats. 5. Alterations during diabetes in production of, and responsiveness to, eicosanoids may contribute to the cardiovascular changes which occur in this disease.
Hodgson
W C
WC
Department of Pharmacology, Monash University, Clayton, Victoria, Australia.
Sikorski
B W
BW
King
R G
RG
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology*; D001792:Blood Platelets / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000503:physiopathology*; D015777:Eicosanoids / Q000494:pharmacology*; D011464:Epoprostenol / Q000378:metabolism; D051381:Rats; D013928:Thromboxane A2 / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects*
D001095:Arachidonic Acids; D015777:Eicosanoids; D013928:Thromboxane A2; D011464:Epoprostenol; D000449:Aldehyde Reductase