title: Recombinant human growth hormone (Genotropin) in treatment of children with growth hormone deficiency: the first year observation.
abstract: Five prepubertal children with previously untreated growth hormone deficiency were enrolled in this trial and treated with authentic recombinant human growth hormone hGH, 0.1 IU/Kg/day, subcutaneously, for one year. All of the children markedly increased their growth rate; the height velocity increased from 3.4 +/- 0.7 cm/yr to 11.3 +/- 2.0 cm/yr during one year's treatment. The height-standard deviation score for chronological age increased from -4.03 +/- 0.52 to -2.70 +/- 0.68. The bone age increased from 5.6 +/- 1.5 year before treatment to 6.4 +/- 1.6 years after one-year treatment. Only one child acquired low titer anti-hGH antibodies during the course of treatment (1:2 to 1:6). No untoward symptoms were complained of by these children and no biochemical abnormalities occurred except transient subclinical hypothyroidism in one child during the treatment course.
authors.affiliation: Department of Medicine, Veterans General Hospital-Taipei, Taiwan, R.O.C.
authors.forename: H F
authors.initials: HF
authors.lastname: Kuo
authors.forename: P C
authors.initials: PC
authors.lastname: Liu
authors.forename: K C
authors.initials: KC
authors.lastname: Shih
authors.forename: T S
authors.initials: TS
authors.lastname: Lee
authors.forename: L T
authors.initials: LT
authors.lastname: Ho
mesh_terms: D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000276:immunology / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone