The behavioural effects of neuropeptide Y (NPY) injection into the rat brain frontal cortex.
The aim of this study was to investigate the influence of intracortical administration of neuropeptide-Y on the behaviour of rats. One week before the behavioural test the frontal cortex of rats was chronically implanted with intracerebral cannulae. Neuropeptide-Y (or saline in the control group) was injected in a volume of 1 microliter. After treatment the behaviour of the rats was tested in an open field apparatus and a light-beam actometer. The number of line crossings, episodes of rearing, sniffing, washing and head poking were counted. The results indicate that administration of neuropeptide-Y to the frontal cortex of rats slightly increased exploratory and locomotor activity.
Smiałowski
A
A
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Lewińska-Gastoł
L
L
Smiałowska
M
M
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects*; D005625:Frontal Lobe / Q000187:drug effects* / Q000502:physiology; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009478:Neuropeptide Y