title: Cardiomyopathy of copper deficiency: effect of vitamin E supplementation.
abstract: The present study was undertaken to determine whether the intraperitoneal injection of vitamin E to copper-(Cu) deficient rats fed fructose will protect the animals against the severity of Cu deficiency. Cu-deficient and adequate rats were fed a diet containing 62% carbohydrate as fructose. Half the Cu-deficient rats fed fructose were injected daily with vitamin E. Vitamin E treated rats were not protected against the lethal consequences of the interaction between Cu and fructose. These data provide evidence that the cardiomyopathy of Cu deficiency in rats consuming a fructose-based diet cannot be ameliorated by vitamin E supplementation.
authors.affiliation: Carbohydrate Nutrition Laboratory, Beltsville Human Nutrition Research Center, MD 20705.
authors.forename: M
authors.initials: M
authors.lastname: Fields
authors.forename: C G
authors.initials: CG
authors.lastname: Lewis
authors.forename: M D
authors.initials: MD
authors.lastname: Lure
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000209:etiology; D003300:Copper / Q000172:deficiency*; D005632:Fructose / Q000633:toxicity; D007501:Iron / Q000032:analysis; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D014810:Vitamin E; D005632:Fructose; D003300:Copper; D007501:Iron