title: Ionic iodinated contrast medium and amobarbital sodium mixtures: potential for precipitation.
abstract: When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.
authors.affiliation: Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: L H
authors.initials: LH
authors.lastname: Monsein
authors.forename: T J
authors.initials: TJ
authors.lastname: Miller
authors.forename: S K
authors.initials: SK
authors.lastname: Kuwahara
authors.forename: S
authors.initials: S
authors.lastname: Sostre
authors.forename: G M
authors.initials: GM
authors.lastname: Debrun
mesh_terms: D000654:Amobarbital; D011232:Chemical Precipitation; D003287:Contrast Media; D003974:Diatrizoate Meglumine
chemical_list: D003287:Contrast Media; D003974:Diatrizoate Meglumine; D000654:Amobarbital