title: The McLean First-Episode Psychosis Project: six-month recovery and recurrence outcome.
abstract: The McLean First-Episode Psychosis project began in 1989. The authors describe the study design, diagnostic distribution, and recovery and relapse data on the first 102 recruited subjects. Fifty-nine percent of the subjects had a diagnosis of bipolar disorder, 15 percent psychotic depression, 10 percent schizophrenic spectrum, 9 percent delusional disorder, and 8 percent other psychotic disorders. By 6 months, 80 percent recovered syndromically but only 55 percent recovered functionally, and only 50 percent recovered both functionally and syndromically. Non-white and male patients were more likely to have a recurrence. Men were less likely and bipolar patients were more likely to recover functionally. Patients with nonaffective psychosis had longer hospitalizations and lower rates of functional recovery 6 months after discharge.
authors.affiliation: McLean Hospital, Belmont, MA 02178.
authors.forename: M
authors.initials: M
authors.lastname: Tohen
authors.forename: A L
authors.initials: AL
authors.lastname: Stoll
authors.forename: S M
authors.initials: SM
authors.lastname: Strakowski
authors.forename: G L
authors.initials: GL
authors.lastname: Faedda
authors.forename: P V
authors.initials: PV
authors.lastname: Mayer
authors.forename: D C
authors.initials: DC
authors.lastname: Goodwin
authors.forename: M L
authors.initials: ML
authors.lastname: Kolbrener
authors.forename: A M
authors.initials: AM
authors.lastname: Madigan
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006760:Hospitalization; D006778:Hospitals, Psychiatric; D006801:Humans; D007407:Interviews as Topic; D007902:Length of Stay; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D044469:Racial Groups; D012107:Research Design; D012737:Sex Factors; D014481:United States / Q000453:epidemiology