title: High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effect.
abstract: The integrity of the blood-brain barrier (BBB) in multiple sclerosis (MS) was monitored by serial gadolinium-(Gd)-DTPA enhanced MRI during and after the treatment of acute relapses with a three day course of high dose intravenous methylprednisolone (IVMP). During treatment there was a rapid reduction of BBB abnormalities in 96% of enhancing lesions. In spite of sustained clinical improvement, many lesions re-enhanced within a few days of stopping IVMP, and new lesions frequently appeared within one month. It is possible that the rapid, albeit transient, reversal of BBB abnormalities contributes to the accelerated recovery from relapses associated with IVMP treatment.
authors.affiliation: Institute of Neurology, London, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
authors.forename: S P
authors.initials: SP
authors.lastname: Morrissey
authors.forename: D G
authors.initials: DG
authors.lastname: MacManus
authors.forename: S G
authors.initials: SG
authors.lastname: Moore
authors.forename: B E
authors.initials: BE
authors.lastname: Kendall
authors.forename: I F
authors.initials: IF
authors.lastname: Moseley
authors.forename: W I
authors.initials: WI
authors.lastname: McDonald
mesh_terms: D000328:Adult; D001812:Blood-Brain Barrier; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D002555:Cerebrospinal Fluid; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology; D011859:Radiography; D012030:Refractive Errors / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D008775:Methylprednisolone