Nonsteroidal antiinflammatory agents. Part 21: optically active stereoisomers of p-trifluoromethylphenyl- and p-thioanisyl-biphenylyl- hydroxypropionic acids.
The synthesis, diastereomeric separation, assignment to erythro- and threo-configuration by 1HNMR, and optical resolution of 3-(p-trifluoromethyl-phenyl)- and (p-thioanisyl)-2-biphenylyl-3-hydroxypropionic acids are described. The enantiomers were submitted to a preliminary assay to determine antiinflammatory activity.
Varoli
L
L
Dipartimento di Scienze Farmaceutiche dell'Università di Bologna, Italia.
Burnelli
S
S
Guarnieri
A
A
Scapini
G
G
Andrisano
V
V
Lumachi
B
B
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy / Q000503:physiopathology; D006880:Hydroxy Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001713:Biphenyl Compounds; D006880:Hydroxy Acids; C075267:4-thioanisyl-2-biphenylyl-3-hydroxypropionic acid; C075266:4-trifluoromethylphenyl-2-biphenylyl-3-hydroxypropionic acid; D002351:Carrageenan