Syntheses, interfacial active properties and toxicity of new perfluoroalkylated surfactants.
New surfactants have been synthesized with perfluorohexyl-groups as hydrophobic tail, a polyethyleneglycol-methylether as hydrophilic head and a prolongator between them. The prolongator units are -C4H8-, -C2H4OC5H10-, -C2H4OC3H6C(O)- and -CH2CH(OEt)CH2-. The surface tension, CMC and the interfacial tension water/perfluorocarbon were measured and the surface excess concentrations of the surfactant molecules were calculated. The influence of the surfactants on in vitro proliferation of human cell lines Hela and Molt 4 was investigated as a parameter for biocompatibility. The influence of the surfactants led to a reduction of cell proliferation depending on the concentration and chemical nature of the surfactant. Thus the prolongators changed the properties of the surfactants. They reduced the interfacial tension water/perfluorocarbon and improved the biocompatibility of surfactants.
Meinert
H
H
Universität Ulm, Lehrstuhl Chemie biokompatibler Verbindugen, Federal Republic of Germany.
Reuter
P
P
Mader
J
J
Haidmann
L
L
Northoff
H
H
D001672:Biocompatible Materials; D001802:Blood Substitutes / Q000138:chemical synthesis*; D002455:Cell Division / Q000187:drug effects; D005466:Fluorocarbons / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D013500:Surface Tension; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D001672:Biocompatible Materials; D001802:Blood Substitutes; D005466:Fluorocarbons; D013501:Surface-Active Agents