Treatment of neonatal renovascular hypertension with intravenous enalapril.
Hypertension in the neonate is commonly related to renal disease. More specifically, renovascular hypertension in neonates is often associated with the placement of a umbilical artery catheter. Many medications, including angiotensin-converting enzyme (ACE) inhibitors, have been used in the treatment of neonatal hypertension. Captopril, an ACE inhibitor, is an oral agent that is effective in renovascular hypertension. We describe the use of intravenous enalapril, another ACE inhibitor, in successfully treating severe renovascular hypertension refractory to standard medical therapy in two term neonates.
Mason
T
T
Department of Pediatrics, West Virginia School of Medicine, Morgantown 26506.
Polak
M J
MJ
Pyles
L
L
Mullett
M
M
Swanke
C
C
D002406:Catheterization, Peripheral / Q000009:adverse effects; D004656:Enalapril / Q000008:administration & dosage / Q000627:therapeutic use*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D006978:Hypertension, Renovascular / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D007231:Infant, Newborn; D007275:Injections, Intravenous; D007668:Kidney / Q000000981:diagnostic imaging; D008297:Male; D009599:Nitroprusside / Q000627:therapeutic use; D011877:Radionuclide Imaging; D014469:Umbilical Arteries
D009599:Nitroprusside; D004656:Enalapril