[Potentiation of the acute toxic effects of cocaine by ethyl alcohol].
Ethyl alcohol increases significantly the lethality of cocaine intoxication in the rat. This lethality is not modified by nicardipine or flunarizine, antidotes to cocaine, and might be due to the formation of a newly identified active metabolite cocaethylene. In addition alcohol like cocaine inhibits the baro receptor reflex.
Nahas
G
G
Laboratoire de pharmacologie et toxicologie cellulaire, INSERM, hôpital Fernand Widal, Paris.
Latour
C
C
Trouvé
R
R
D000818:Animals; D003042:Cocaine / Q000008:administration & dosage / Q000633:toxicity*; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D003042:Cocaine
Potentialisation des effets toxiques aigus de la cocaïne par l'alcool éthylique.