Cellular retinol-binding protein functions in the regulation of retinoid metabolism.
A microsomal retinyl ester hydrolase from rat tissues is activated by apo-cellular retinol-binding protein, which thus regulates the availability of retinol either for binding to serum retinol-binding protein or for metabolic oxidation. Microsomal retinal synthesis was found to occur in rat tissues with holo-cellular retinol-binding protein as substrate. Retinal could be further oxidized to retinoic acid by a cytosolic fraction.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720.
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D008861:Microsomes / Q000201:enzymology; D051381:Rats; D012176:Retinoids / Q000378:metabolism*; D012177:Retinol-Binding Proteins / Q000502:physiology*; D054840:Retinol-Binding Proteins, Cellular
D012176:Retinoids; D012177:Retinol-Binding Proteins; D054840:Retinol-Binding Proteins, Cellular; D002265:Carboxylic Ester Hydrolases; C022523:retinyl esterase