title: Quantitative early phase scintigraphy in the prediction of healing of tibial fractures.
abstract: Imaging with technetium-99m methylene diphosphonate (99mTc-MDP) is established in the diagnosis of infection, neoplasia and ischaemic necrosis in orthopaedic practice, but its role in fracture healing is less well-defined. Previous studies have shown a relationship between fracture site activity (region A), activity in adjacent normal bone (region C) and time to union. The predictive value of the A/C ratio of the image obtained 300-800 s after injection was assessed in a prospective study of 50 patients with closed tibial fractures managed with plaster casts, external fixators and intramedullary nails. There were significant differences in absolute uptake and A/C ratio between the three groups (P less than 0.05), but this was not related to time to union. Reamed nailing alters the distribution of 99m-Tc-MDP uptake so as to reduce the A/C ratio (1.10 +/- 0.20), but there is a promising role for early phase bone scanning in non-operative (A/C = 1.40 +/- 0.21) or externally fixed (A/C = 1.26 +/- 0.22) fractures in conjunction with other non-invasive methods of monitoring the biomechanical environment.
authors.affiliation: Department of Orthopaedic Surgery, University of Edinburgh Medical School, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Wallace
authors.forename: R K
authors.initials: RK
authors.lastname: Strachan
authors.forename: A
authors.initials: A
authors.lastname: Blane
authors.forename: J J
authors.initials: JJ
authors.lastname: Best
authors.forename: S P
authors.initials: SP
authors.lastname: Hughes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013669:Technetium Tc 99m Medronate; D013978:Tibial Fractures / Q000000981:diagnostic imaging* / Q000601:surgery; D014945:Wound Healing
chemical_list: D013669:Technetium Tc 99m Medronate