A delayed response to acute stimulation with human chorionic gonadotropin in scorbutic rats.
Since our previous study revealed low basal testosterone (T) levels and a failure in response to an acute stimulation with human chorionic gonadotropin (HCG) despite of a good response to chronic stimulation in scorbutic mutant rats, time course of the response to HCG was studied and plasma LH level was measured in young adult rats deficient in ascorbic acid for 3 weeks. A single subcutaneous injection of HCG (200 IU) elevated T levels only slightly in plasma and not in testicular tissues of scorbutic rats 1 h after the injection when the levels in ascorbutic rats reached a maximum, while it yielded the same response pattern as in ascorbutic rats after 3 h. A pretreatment with HCG to scorbutic rats for 1 or 4 days resulted in the same response of plasma T as in ascorbutic rats. Plasma LH levels in unstimulated scorbutic rats were about 40% of those in ascorbutic rats. These findings indicate that a prolonged deficiency of ascorbic acid decreases plasma LH, and may reduce the sensitivity of testes to LH.
Ito
Y
Y
Department of Pathology, Osaka Medical College, Takatsuki, Japan.
Tsuji
M
M
Miyano
M
M
Wakabayashi
K
K
Mori
H
H
D000818:Animals; D001206:Ascorbic Acid Deficiency / Q000097:blood / Q000503:physiopathology; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007279:Injections, Subcutaneous; D007986:Luteinizing Hormone / Q000097:blood* / Q000502:physiology; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011922:Rats, Mutant Strains; D012614:Scurvy / Q000097:blood* / Q000503:physiopathology; D013737:Testis / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D013739:Testosterone / Q000032:analysis / Q000097:blood*; D013997:Time Factors
D006063:Chorionic Gonadotropin; D013739:Testosterone; D007986:Luteinizing Hormone