Local production of interleukin-8 is associated with nosocomial pneumonia.
One hundred five (70%) of 151 patients hospitalized in the intensive care unit and undergoing mechanical ventilation had bronchial secretions that tested positive for interleukin-8 within 36 hours of admission. Arterial blood, mixed venous blood, and urine collected simultaneously all tested negative, except for 11 patients admitted with intra-abdominal septic foci. The presence of interleukin-8 in the pulmonary air space early in the course of hospitalization was significantly associated with patients with multiple injuries, the need for greater ventilatory support, the occurrence of pulmonary dysfunction, and a 66% incidence of nosocomial bacterial pneumonia. We conclude that the early local production of interleukin-8 in the lungs is an early marker of pulmonary injury and may be involved in the pathogenesis of nosocomial bacterial pneumonia.
Rodriguez
J L
JL
Department of Surgery, University of Michigan, Ann Arbor 48109-0033.
Miller
C G
CG
DeForge
L E
LE
Kelty
L
L
Shanley
C J
CJ
Bartlett
R H
RH
Remick
D G
DG
D000328:Adult; D015152:Blotting, Northern; D001980:Bronchi / Q000378:metabolism; D003428:Cross Infection / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016209:Interleukin-8 / Q000096:biosynthesis* / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000150:complications* / Q000378:metabolism; D011018:Pneumonia, Pneumococcal / Q000209:etiology* / Q000378:metabolism; D011446:Prospective Studies
D016209:Interleukin-8