Does the HIV envelope induce a chronic graft-versus-host-like disease?
Evidence is accumulating that susceptibility to disease following HIV infection is genetically restricted. In addition, activation of the immune response appears to play an important role in disease progression. Here, John Habeshaw and colleagues propose that HIV envelope glycoproteins mimic foreign MHC molecules and, in doing so, stimulate alloreactive lymphocytes. This activation may explain the marked clinical and immunological similarities between chronic GVHD and AIDS.
Habeshaw
J
J
London Hospital Medical School, UK.
Hounsell
E
E
Dalgleish
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D000595:Amino Acid Sequence; D002908:Chronic Disease; D004198:Disease Susceptibility / Q000276:immunology; D015686:Gene Products, env / Q000737:chemistry / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D006086:Graft vs Host Disease; D006678:HIV / Q000276:immunology / Q000472:pathogenicity*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000276:immunology*; D019302:HIV Envelope Protein gp160; D006681:HLA-D Antigens / Q000737:chemistry / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007519:Isoantigens / Q000737:chemistry / Q000276:immunology; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011498:Protein Precursors / Q000737:chemistry / Q000276:immunology*; D013329:Structure-Activity Relationship
D015686:Gene Products, env; D015699:HIV Envelope Protein gp120; D019302:HIV Envelope Protein gp160; D006681:HLA-D Antigens; D007519:Isoantigens; D011498:Protein Precursors