[Study of the role of adrenergic vasoconstriction in the development of dynamic coronary obstruction in patients with stress-induced stenocardia].
The aim of the present investigation was to evaluate sympathetic vasoconstrictor influence and to define its role in the formation of coronary occlusion in patients with effort angina. The investigation covered 22 patients with Functional Class II-III stable effort angina. To detect vasoconstrictor responses on exercise and to identify their adrenergic component, pair bicycle tests were performed before and after administration of nitroglycerin and pratsiol. Repeated bicycle tests were conducted twice a day: at 10-11 a.m. and at 3-4 p.m. to study spontaneous exercise tolerance variations confirming the presence of dynamic coronary occlusion. The examinations indicated that in 18 patients the exercise resulted in functional major artery narrowing, aggravating the organic stenosis. Activation of smooth muscle alpha-adrenoreceptors is of a definite significance in the genesis of dynamic coronary occlusion in 50% of all the examinees.
Kuleshova
E V
EV
Antonova
I S
IS
Lokhovinina
N L
NL
Lopukhov
A A
AA
Moroshkin
V S
VS
Tsyrlin
V A
VA
D000320:Adrenergic Fibers / Q000502:physiology*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000209:etiology / Q000503:physiopathology*; D003327:Coronary Disease / Q000209:etiology*; D003331:Coronary Vessels / Q000294:innervation* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000294:innervation* / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*; D014661:Vasoconstriction / Q000502:physiology*
Izuchenie roli adrenergicheskoĭ vazokonstriktsii v formirovanii dinamicheskoĭ koronarnoĭ obstruktsii u bol'nykh so stenokardieĭ napriazheniia.