The association of astrocytoma and pituitary adenoma in a patient with alcaptonuria.
A female patient with a juvenile pilocytic astrocytoma and a pituitary adenoma is described. The patient also has alcaptonuria, a rare inborn error of metabolism with autosomal recessive mode of inheritance. The association of these three disorders has never been reported previously. The possible existence of a common genetic factor in the development of both tumors and alcaptonuria is discussed.
Abs
R
R
Department of Endocrinology, University of Antwerp, Belgium.
Van Vyve
M
M
Willems
P J
PJ
Neetens
I
I
Van der Auwera
B
B
Van den Ende
E
E
Van de Kelft
E
E
Beckers
A
A
Van Marck
E
E
Martin
J J
JJ
D000236:Adenoma / Q000150:complications* / Q000235:genetics; D000328:Adult; D000474:Alkaptonuria / Q000150:complications* / Q000235:genetics; D001254:Astrocytoma / Q000150:complications* / Q000235:genetics; D001932:Brain Neoplasms / Q000150:complications* / Q000235:genetics; D003388:Cranial Fossa, Posterior; D005260:Female; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000235:genetics; D010911:Pituitary Neoplasms / Q000150:complications* / Q000235:genetics