title: Guillain-Barré syndrome associated with high titers of anti-GM1 antibodies.
abstract: We found high titers of anti-GM1 antibodies (1/1280 or more) in 3 of 14 consecutive patients (21%) with Guillain-Barré syndrome (GBS) and in 2 additional patients who developed GBS, 10-11 days after starting parenteral treatment with gangliosides. Antibodies were IgG in 4 patients and IgM in one, and they all bound to asialo-GM1, and, in 3, to GD1b as well. Although the clinical features in all the patients with high anti-GM1 titers fulfilled the criteria for the diagnosis of GBS and in 4 of them, proteins but not cells were elevated in cerebrospinal fluid, electrodiagnostic studies in 3 patients showed prominent signs of axonal degeneration, that in one case were confirmed by morphological studies on sural nerve biopsy. No recent antecedent infection was reported by these patients, but in 3, including patients treated with gangliosides, anti-Campylobacter jejuni antibodies were elevated. In 3 patients a consistent decrease in anti-GM1 levels was observed after the acute phase of the disease suggesting that the frequent occurrence of these antibodies in patients with GBS and their frequent association with a prominent axonal impairment may have pathogenetic relevance.
authors.affiliation: Institute of Clinical Neurology, Centro Dino Ferrari, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Nobile-Orazio
authors.forename: M
authors.initials: M
authors.lastname: Carpo
authors.forename: N
authors.initials: N
authors.lastname: Meucci
authors.forename: M P
authors.initials: MP
authors.lastname: Grassi
authors.forename: E
authors.initials: E
authors.lastname: Capitani
authors.forename: M
authors.initials: M
authors.lastname: Sciacco
authors.forename: A
authors.initials: A
authors.lastname: Mangoni
authors.forename: G
authors.initials: G
authors.lastname: Scarlato
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004576:Electromyography; D004594:Electrophysiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration; D009431:Neural Conduction / Q000502:physiology; D011129:Polyradiculoneuropathy / Q000276:immunology* / Q000503:physiopathology
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005677:G(M1) Ganglioside