Patchy distribution of rejection changes in small intestinal transplantation.
The aim of this study is to determine the distribution of histological changes of rejection in small intestinal transplantation. Thirty-nine rats were randomized into two groups: group I (n = 15), syngeneic transplants and group II (n = 24), allogeneic transplants. Grafts were excised and examined on days 2, 4, and 8 after transplantation. All grafts of the syngeneic group showed normal mucosa by day 4. However, by this time, all grafts of the allogeneic group demonstrated rejection changes with a patchy distribution in the mucosa. Therefore, with a biopsy from the stoma site there is a risk of missing early rejection.
Yamataka
A
A
Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan.
Miyano
T
T
Fukunaga
K
K
Kobayashi
H
H
Nozawa
M
M
Sasaki
K
K
D000818:Animals; D006084:Graft Rejection; D006965:Hyperplasia / Q000209:etiology / Q000473:pathology; D007082:Ileum / Q000473:pathology / Q000637:transplantation*; D007413:Intestinal Mucosa / Q000473:pathology / Q000637:transplantation*; D009336:Necrosis; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D013997:Time Factors; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic