[Protective effect of unithiol and its combination with magnesium sulfate in endotoxin poisoning and in infection by gram-negative bacteria].
It is shown that unithiol protects mice from death in intoxication by S. typhimurium and S. Sonnei lysates and in infection caused by S. typhimurium. Magnesium sulfate strengthens the protective effect of unithiol. It is suggested that the protective effect of unithiol is due to its antioxidant action.
Grutman
M I
MI
Persidskiĭ
Iu V
IuV
Frolov
V M
VM
Nagornaia-Persidskaia
R N
RN
Gushla
E P
EP
D000818:Animals; D004359:Drug Therapy, Combination; D004731:Endotoxins / Q000506:poisoning*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D014494:Unithiol / Q000008:administration & dosage / Q000627:therapeutic use*
D004731:Endotoxins; D014494:Unithiol; D008278:Magnesium Sulfate
Zashchitnoe deĭstvie unitiola i ego sochetaniia s sul'fatom magniia pri intoksikatsii éndotoksinami gram-otritsatel'nykh bakteriĭ i infektsii, vyzvannoĭ étimi bakteriiami.