Loss of chromosome 22 in patients with refractory anemia with excess of blasts (RAEB) in transformation and acute leukemia after RAEB.
We report studies of 12 patients with refractory anemia and excess of blasts in transformation (RAEB-t) and 17 with acute myeloblastic leukemia (AML) after RAEB. Besides chromosome 5 and 7 abnormalities, five patients with complex karyotypic changes had monosomy 22. This association is discussed in relation to the hypothesis of a suppressor gene located on chromosome 22.
Berger
R
R
Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Le Coniat
M
M
Derré
J
J
Flexor
M A
MA
D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics* / Q000473:pathology; D001752:Blast Crisis / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009006:Monosomy