A new oesophageal tube: assessment of collagen/vicryl composite membrane.
Collagen/vicryl composite membrane has been previously shown to be of use in an experimental model as a patch graft in the bladder and oesophagus. Attempts to use it as a circumferential tube graft have been unsuccessful due to the development of strictures at the site of anastomosis. We inserted a polytetrafluoroethylene (PTFE) stented collagen/vicryl bioprosthetic tube into rat omentum, which served as a vascular pedicle. Subsequent histology of the graft showed serial replacement of the bioprosthesis with host collagen and the development of a blood supply. In a second stage procedure, the bioprosthesis was anastomosed to the distal ileum and brought out on the skin to form a fistula. Squamous epithelium was subsequently identified growing the full length of the graft. Therefore, we have developed a vascularised bioprosthetic tube graft which will support the growth of unspecialised epithelium. This model could be of use in bridging congenital atresias or pathological strictures.
MacDonald
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Division of Paediatric Surgery, Royal Hospital for Sick Children, Glasgow, Scotland.
Carachi
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R
Gibson
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D000714:Anastomosis, Surgical; D000818:Animals; D001705:Bioprosthesis; D003094:Collagen; D004947:Esophagus / Q000098:blood supply / Q000601:surgery*; D008297:Male; D009852:Omentum / Q000601:surgery*; D010865:Pilot Projects; D011098:Polyglactin 910; D051381:Rats; D011919:Rats, Inbred Strains
D011098:Polyglactin 910; D003094:Collagen