title: Leukemia in children and paternal radiation exposure at the Sellafield nuclear site.
abstract: Childhood cancer around nuclear installations has been studied in recent years, particularly in the United Kingdom but also in other countries. The early studies were prompted by the suggestion of a 10-fold raised level of childhood leukemia around the Sellafield nuclear site in England, which was confirmed and followed by the identification of generally smaller excesses around some (but not all) other nuclear sites in the United Kingdom. Marked excesses have not been reported in other countries. The increased leukemia rate around Sellafield has been further investigated by examining individual cases in detail in epidemiological cohort and case-control studies. The raised incidence seems to have been concentrated in children born in the local area but not among children who moved in after birth and was particularly associated with fathers who had experienced higher levels of occupational external ionizing radiation exposure at Sellafield before their children's conception. The underlying cause of this statistical association is not yet clear, but the findings have important potential implications for radiobiology and for protection of radiation workers and their children.
authors.affiliation: MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gardner
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D004739:England / Q000453:epidemiology; D005220:Fathers; D005260:Female; D006801:Humans; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009688:Nuclear Reactors; D016273:Occupational Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects