Lymph node histology simulating T-cell lymphoma in adult-onset Still's disease.
A patient with adult-onset Still's disease (AOSD) underwent lymph node biopsy as part of initial evaluation for fever of unknown origin. The lymph node histology showed a massive, diffuse immunoblastic hyperplasia, simulating T-cell lymphoma. This nodal histology differs from rheumatoid arthritis, where mostly a follicular B-cell reaction predominates. Evaluating fever of unknown origin when one is unacquainted with this massive immunoblastic hyperplasia can lead to the wrong diagnosis of T-cell lymphoma in patients with AOSD.
Reichert
L J
LJ
Department of Internal Medicine, University Hospital St. Radboud, Nijmegen, The Netherlands.
Keuning
J J
JJ
van Beek
M
M
van Rijthoven
A W
AW
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D016706:Still's Disease, Adult-Onset / Q000473:pathology*