title: Lymph node histology simulating T-cell lymphoma in adult-onset Still's disease.
abstract: A patient with adult-onset Still's disease (AOSD) underwent lymph node biopsy as part of initial evaluation for fever of unknown origin. The lymph node histology showed a massive, diffuse immunoblastic hyperplasia, simulating T-cell lymphoma. This nodal histology differs from rheumatoid arthritis, where mostly a follicular B-cell reaction predominates. Evaluating fever of unknown origin when one is unacquainted with this massive immunoblastic hyperplasia can lead to the wrong diagnosis of T-cell lymphoma in patients with AOSD.
authors.affiliation: Department of Internal Medicine, University Hospital St. Radboud, Nijmegen, The Netherlands.
authors.forename: L J
authors.initials: LJ
authors.lastname: Reichert
authors.forename: J J
authors.initials: JJ
authors.lastname: Keuning
authors.forename: M
authors.initials: M
authors.lastname: van Beek
authors.forename: A W
authors.initials: AW
authors.lastname: van Rijthoven
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D016706:Still's Disease, Adult-Onset / Q000473:pathology*