Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat.
Plasma post-heparin diamine oxidase (DAO) activity and plasma levels of plant sterols were examined in streptozotocin diabetic rats fed with chow containing plant sterols, to investigate the enzyme activity in relation to the morphological changes of small intestine as well as sterol absorption in the diabetic rats. Diabetic rats showed increased small intestinal mass and surface area compared with control rats. Plasma post-heparin DAO activity and plant sterol level were also increased more than 2.5-fold in the diabetic rats. Insulin treatment improved these abnormalities. Plasma DAO activity correlated to both the small intestinal hyperplastic change and plasma plant sterol levels. These results indicate that plasma post-heparin DAO activity may be used as a marker of intestinal hypertrophy as well as ability to absorb dietary sterols.
Kojima
H
H
Third Department of Medicine, Shiga University of Medical Science, Japan.
Omoto
Y
Y
Hidaka
H
H
Aoki
T
T
Nakamura
T
T
Kawabata
T
T
Konaka
K
K
Kashiwagi
A
A
Kikkawa
R
R
Shigeta
Y
Y
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D000704:Analysis of Variance; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D003897:Desmosterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D006493:Heparin; D006965:Hyperplasia; D007421:Intestine, Small / Q000473:pathology; D007700:Kinetics; D008297:Male; D010944:Plants; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013261:Sterols / Q000097:blood*
D013261:Sterols; D003897:Desmosterol; D006493:Heparin; D002784:Cholesterol; D006631:Amine Oxidase (Copper-Containing)