title: Dose proportionality study of loperamide following oral administration of loperamide oxide.
abstract: The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
authors.affiliation: Wolfson Unit of Clinical Pharamcology, The University, Newcastle upon Tyne, UK.
authors.forename: F
authors.initials: F
authors.lastname: Kamali
authors.forename: L
authors.initials: L
authors.lastname: Adriaens
authors.forename: M L
authors.initials: ML
authors.lastname: Huang
authors.forename: R
authors.initials: R
authors.lastname: Woestenborghs
authors.forename: M
authors.initials: M
authors.lastname: Emanuel
authors.forename: M D
authors.initials: MD
authors.lastname: Rawlins
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D001682:Biological Availability; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008139:Loperamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D008297:Male
chemical_list: D008139:Loperamide; C066043:loperamide oxide