Evaluation of the interaction of benzene and toluene on the urinary excretion of t,t-muconic acid in rats.
The influence of simultaneous exposure to benzene and toluene on the urine excretion of t,t-muconic acid (t,t-MA) was examined in rats. t,t-MA was measured from 24-h urine of rats subjected to a single 4-h exposure to 5 or 20 ppm benzene and/or 50, 100, 200 or 1000 ppm toluene. Coexposure lowered t,t-MA excretion in a concentration-dependent manner, especially in the 20 ppm benzene group where the decrease averaged 28, 44 and 85% after exposure to 100, 200 and 1000 ppm toluene, respectively, as compared to benzene-exposed groups alone. The data confirm the sensitivity of t,t-MA as an indicator of benzene exposure and point out that measurement of t,t-MA may underestimate the exposure to benzene in the presence of toluene.
Brondeau
M T
MT
Institut National de Recherche et de Sécurité, Vandoeuvre, France.
Ducos
P
P
Gaudin
R
R
Morel
G
G
Bonnet
P
P
de Ceaurriz
J
J
D000280:Administration, Inhalation; D000818:Animals; D001554:Benzene / Q000633:toxicity*; D004347:Drug Interactions; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D014050:Toluene / Q000633:toxicity*
D014050:Toluene; C005939:muconic acid; D001554:Benzene; D013011:Sorbic Acid