title: [Healing of tympanic membrane perforation-a complex process influenced by a variety of factors].
abstract: It is known that the healing of a perforated tympanic membrane can be influenced by mechanical procedures as well as drugs. Animal experiments have recently shown that local treatment with steroids delays the healing of a tympanic membrane perforation, whereas hyaluronan (hyaluronic acid) improves the healing rate as well as the quality of the scar. Hyaluronan, a non-sulphated glycosaminoglycan, belongs to the extracellular matrix substances. In the present study another glycosaminoglycan--heparin--was applied on experimental tympanic membrane perforations. This report confirmed that also this extracellular matrix substance improves the healing rate of a tympanic membrane perforation and the scar quality.
authors.affiliation: Oron-Näs och Halskliniken, Umeå Universitet, Sverige.
authors.forename: O
authors.initials: O
authors.lastname: Spandow
authors.forename: S
authors.initials: S
authors.lastname: Hellström
mesh_terms: D006493:Heparin / Q000494:pharmacology; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology; D014432:Tympanic Membrane / Q000293:injuries / Q000503:physiopathology*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D006820:Hyaluronic Acid; D006493:Heparin
vernacular_title: Läkning av trumhinneperforation--en komplex process påverkbar av många faktorer.