Alcohol dehydrogenase (ADH). Influence of homo- and heterologous ADH administration on albino rats craving for alcohol and on ADH isozyme activity in the liver.
The effects of homo- and heterologous alcohol dehydrogenase (ADH) administration into albino rats were investigated. It was found that homologous ADH increases and heterologous ADH decreases the craving for ethanol. The latter effect was accompanied by the appearance of anti-ADH-3 antibodies and by a decrease in ADH-3 activity in the liver. Craving for alcohol decreased after both active and passive immunization against ADH.
Ashmarin
I P
IP
Department of Human and Animal Physiology, School of Biology, Moscow University, Russia.
Danilova
R A
RA
Pshezhetsky
A V
AV
Fedorova
I M
IM
Obukhova
M F
MF
Sagimbaeva
Sh K
ShK
D000426:Alcohol Dehydrogenase / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D000428:Alcohol Drinking; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D016739:Behavior, Addictive; D004797:Enzyme-Linked Immunosorbent Assay; D006736:Horses; D007116:Immunization, Passive; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D051381:Rats; D014611:Vaccination
D007527:Isoenzymes; D000426:Alcohol Dehydrogenase