[Do piroxicam and diclofenac impair reaction performance?].
The non-steroid agents diclofenac (1 mg/kg) and piroxicam (0.3 mg/kg) were studied for their performance-influencing effect in an acute placebo controlled cross-over trial involving 11 normal subjects in intraindividual comparison. Various cognitive tests (vigilance measurement, d2-test, concentration performance test), a determination test, and a flicker frequency test did not reveal verum effects when compared to placebo. In contrast, for subjects administered piroxicam, the self-state questionnaire according to Nitsch showed marked positive effects on the motivation and activation on the subjects. Numerical improvements (without being statistically significant) were also seen with respect to outgoingness and exertion increase. Moreover, subjects administered piroxicam were observed to be more concentrated and relaxed, whereas diclofenac exerted no influence on performance and the state of mind.
Meyer
F P
FP
Institut für Klinische Pharmakologie, Medizinischen Akademie Magdeburg.
Kunze
M T
MT
D000328:Adult; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects*; D004008:Diclofenac / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010894:Piroxicam / Q000633:toxicity*; D011597:Psychomotor Performance / Q000187:drug effects*; D012684:Sensory Thresholds / Q000187:drug effects
D010894:Piroxicam; D004008:Diclofenac
Schränken Piroxicam und Diclofenac das Reaktionsvermögen ein?