The effect of vasoactive intestinal peptide (VIP) and naloxone combination on survival rates in rats exposed to severe hemorrhage.
In this experiment, the effects of different doses of vasoactive intestinal peptide (VIP) and naloxone (NLX) combinations on survival rates were investigated in rats exposed to 40% hemorrhage. A combination of 25 ng.kg-1 VIP+5 mg.kg-1 NLX showed the best results on survival. The important prospect of this combination is to have the most potent inhibitory effect on mast cell degranulation. When this combination was given together with shed blood reperfusion and 7.5% NaCl, survival rate increased relative to the administration of shed blood alone and of 7.5% NaCl. These findings suggest that inhibition of mast cell degranulation has a beneficial effect on severe hemorrhage.
Tikiz
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Department of Physiology, Faculty of Medicine, University of Anadolu, Eskişehir, Türkiye.
Tunçel
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N
Akin
M Z
MZ
Gürer
F
F
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015550:Cell Degranulation / Q000187:drug effects; D004195:Disease Models, Animal; D004338:Drug Combinations; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006470:Hemorrhage / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D009270:Naloxone / Q000627:therapeutic use*; D051381:Rats; D015996:Survival Rate; D014660:Vasoactive Intestinal Peptide / Q000627:therapeutic use*
D004338:Drug Combinations; D009270:Naloxone; D014660:Vasoactive Intestinal Peptide