title: Degenerative changes in traumatic brain injury: post-injury magnetic resonance identified ventricular expansion compared to pre-injury levels.
abstract: Magnetic resonance (MR) scans obtained 42 days and 10 months post-injury were compared to scans obtained in similar planes three months prior to injury. In comparison to pre-injury scans, post-injury MR scan analysis demonstrated significant ventricular volume increase which is considered a measure of the degree of diffuse axonal injury. Most important, the trauma induced degenerative effects appeared to be quite complete by 42 days post-injury as there was little further degeneration that occurred between the 6 week and 10 month post-injury scans. This study demonstrates that in humans the majority of gross trauma-induced degenerative changes are complete by 6 weeks post-trauma.
authors.affiliation: Department of Psychology, Brigham Young University, Provo, Utah 84602.
authors.forename: E D
authors.initials: ED
authors.lastname: Bigler
authors.forename: S M
authors.initials: SM
authors.lastname: Kurth
authors.forename: D
authors.initials: D
authors.lastname: Blatter
authors.forename: T J
authors.initials: TJ
authors.lastname: Abildskov
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male