title: Zidovudine pharmacokinetics during pregnancy.
abstract: As the indications for zidovudine (ZDV) treatment in human immunodeficiency virus-infected individuals expand, we anticipate an increased use of this drug during pregnancy. We report pharmacokinetics data from a patient studied both in the third trimester and intrapartum. ZDV peak-plasma levels and serum half-lives were comparable to nonpregnant adults. High concentrations of ZDV and its glucuronide metabolite were found in umbilical cord blood and in amniotic fluid.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Science, Mount Sinai School of Medicine, New York, New York 10029.
authors.forename: R S
authors.initials: RS
authors.lastname: Sperling
authors.forename: J
authors.initials: J
authors.lastname: Roboz
authors.forename: R
authors.initials: R
authors.lastname: Dische
authors.forename: D
authors.initials: D
authors.lastname: Silides
authors.forename: I
authors.initials: I
authors.lastname: Holzman
authors.forename: E
authors.initials: E
authors.lastname: Jew
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000378:metabolism*; D015215:Zidovudine / Q000032:analysis / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D015215:Zidovudine