Detailed mapping of the Rfv-1 gene that influences spontaneous recovery from Friend retrovirus-induced leukaemia.
Using H-2 recombinant and mutant mice, the Rfv-1 gene influencing spontaneous recovery from Friend retrovirus (FV)-induced leukaemia was mapped in the D locus. Two Db alleles were required for full recovery, and a single Dd transgene did not convey increased susceptibility to FV in the presence of homozygous Db/b genotype. The results suggest that an increase in the expression of Db may lead to more effective stimulation of FV-specific CTL.
Miyazawa
M
M
Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infections Diseases, Hamilton, MT.
Nishio
J
J
Wehrly
K
K
Jay
G
G
Melvold
R W
RW
Chesebro
B
B
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D005622:Friend murine leukemia virus; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D007942:Leukemia, Experimental / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D006183:H-2 Antigens