title: Presence and possible origin of epsilon(gamma-glutamyl)lysine isodipeptide in human plasma.
abstract: epsilon(gamma-glutamyl)lysine isodipeptide has been detected in normal human plasma by a sensitive HPLC technique in a concentration of 1.9-3.6 mumol/l. Incubation of in vitro clotted plasma at 37 degrees C for 12 h resulted in an increased amount of isodipeptide, and there was no further significant change when streptokinase was also present. Increased in vivo isodipeptide concentrations were also observed in hypercoagulable states and during fibrinolytic therapy.
authors.affiliation: 2nd Department of Medicine, University School of Medicine, Debrecen, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Harsfalvi
authors.forename: E
authors.initials: E
authors.lastname: Tarcsa
authors.forename: M
authors.initials: M
authors.lastname: Udvardy
authors.forename: G
authors.initials: G
authors.lastname: Zajka
authors.forename: T
authors.initials: T
authors.lastname: Szarvas
authors.forename: L
authors.initials: L
authors.lastname: Fesus
mesh_terms: D001778:Blood Coagulation Disorders / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004151:Dipeptides / Q000097:blood*; D005342:Fibrinolysis; D006801:Humans
chemical_list: D004151:Dipeptides; C001299:epsilon-(gamma-glutamyl)-lysine