Basic fibroblast growth factor (bFGF) acts centrally in the brain to inhibit gastric emptying in rats.
In the present study, we evaluated the central nervous system action of basic fibroblast growth factor (bFGF) on gastric emptying of a liquid meal in conscious rats using a Phenol red method. Intracisternal injection of bFGF dose-dependently inhibited gastric emptying, while intraperitoneal injection of bFGF at the same doses failed to alter gastric emptying. These results suggest for the first time that bFGF acts in the central nervous system to delay gastric emptying.
Okumura
T
T
Department of Internal Medicine III, Asahikawa Medical College, Hokkaido, Japan.
Uehara
A
A
Kitamori
S
S
Watanabe
Y
Y
Taniguchi
Y
Y
Tsuji
K
K
Namiki
M
M
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000502:physiology*; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D016222:Fibroblast Growth Factor 2