Structure of the murine gene encoding apolipoprotein A-I.
A 1.6-kb DNA fragment containing the gene encoding apolipoprotein A-I from the mouse, Mus musculus, has been cloned and sequenced. It contains three exons separated by two introns and encodes a secreted polypeptide of 262 amino acids (aa), 238 of which constitute the mature protein. Comparisons with the rat and human proteins indicate moderate levels of shared identity (71 and 66%, respectively), although the overall aa compositions yield proteins with identical pIs (5.4). Kyte-Doolittle analyses of the three proteins indicate that there is no significant difference in the structure of these apolipoproteins.
Boyle
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Upjohn Laboratories, Kalamazoo, MI 49007.
Marotti
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D000595:Amino Acid Sequence; D000818:Animals; D016632:Apolipoprotein A-I / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics; D015698:Genomic Library; D007438:Introns / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data
D016632:Apolipoprotein A-I