4-Borono-2-[18F]fluoro-D,L-phenylalanine: a possible tracer for melanoma diagnosis with PET.
The potential of 4-borono-2-[18F]fluoro-D,L-phenylalanine ([18F]FBPA), a flurodinated derivative of a target compound for boron neutron capture therapy, for melanoma imaging by positron emission tomography (PET) was studied using animal models. A high uptake of [18F]FBPA was found in murine B16 melanoma or in Greene's melanoma No. 179, a melanotic cell line in hamsters, for the first 6 h after injection. Whole body autoradiography using [18F]FBPA gave a clear image of the B16 tumor. The acid-insoluble 18F in the B16 increased to 27% by 6 h, and most of the free 18F was detected as [18F]FBPA in both B16 and plasma. In the hamster models, No. 179 showed a 1.7 times higher uptake than amelanotic Greene's melanoma No. 178 at 6 h post-injection, although both melanomas indicated similar metabolic activities when examined by a tracer uptake study using L-[14C]methionine, 2-deoxy-D-[14C]glucose and [3H]thymidine. [18F]FBPA may be a very promising PET tracer for melanoma imaging.
Ishiwata
K
K
Division of Radiopharmaceutical Chemistry, Tohoku University, Japan.
Ido
T
T
Honda
C
C
Kawamura
M
M
Ichihashi
M
M
Mishima
Y
Y
D000818:Animals; D001345:Autoradiography; D001896:Boron Compounds / Q000378:metabolism / Q000493:pharmacokinetics; D002250:Carbon Radioisotopes; D006224:Cricetinae; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D008647:Mesocricetus; D051379:Mice; D009368:Neoplasm Transplantation; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods; D014407:Tumor Cells, Cultured; D014915:Whole-Body Counting
D001896:Boron Compounds; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; C072915:4-borono-2-fluorophenylalanine; D010649:Phenylalanine; D003847:Deoxyglucose