Ionic iodinated contrast medium and amobarbital sodium mixtures: potential for precipitation.
When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.
Monsein
L H
LH
Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.
Miller
T J
TJ
Kuwahara
S K
SK
Sostre
S
S
Debrun
G M
GM
D000654:Amobarbital; D011232:Chemical Precipitation; D003287:Contrast Media; D003974:Diatrizoate Meglumine
D003287:Contrast Media; D003974:Diatrizoate Meglumine; D000654:Amobarbital