title: Bioassay of interleukin 1 (IL-1) in human gingival crevicular fluid during experimental gingivitis.
abstract: The cytokine IL-1 was demonstrated in crevicular fluid during a 14- and 21-day experimental gingivitis in healthy human volunteers. A sensitive and specific bioassay allowed detection of biologically active IL-1 at levels ranging from 0.18 ng/microliters at baseline to 1.70 ng/microliters in inflamed gingiva. Levels of IL-1 increased rapidly with plaque accumulation and in advance of the subsequent gingival inflammation, peaking within 7 days of the start of gingivitis. As changes in IL-1 were detected before clinically recognizable gingival changes, IL-1 may have potential as an early marker of gingival inflammatory changes.
authors.affiliation: Department of Oral Medicine and Pathology, University of Glasgow Dental School, U.K.
authors.forename: D F
authors.initials: DF
authors.lastname: Kinane
authors.forename: F P
authors.initials: FP
authors.lastname: Winstanley
authors.forename: E
authors.initials: E
authors.lastname: Adonogianaki
authors.forename: N A
authors.initials: NA
authors.lastname: Moughal
mesh_terms: D000328:Adult; D003774:Dental Plaque Index; D005260:Female; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000276:immunology; D005891:Gingivitis / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008297:Male; D010512:Periodontal Index; D012044:Regression Analysis
chemical_list: D007375:Interleukin-1