Crossed signals: oncogenic transcription factors.
Transcription factors operate at key regulatory junctions in the cell's responses to diverse extracellular stimuli. We discuss how the transforming activity of mutated transcription factors encoded by several oncogenes (v-erbA, v-fos, v-jun and v-rel) may result in part from a loss of the integrated response to the signalling network.
Forrest
D
D
Roche Institute of Molecular Biology, Department of Molecular Oncology and Virology, Nutley, New Jersey 07110.
Curran
T
T
D016762:Genes, fos; D016758:Genes, jun; D009154:Mutation; D009857:Oncogenes; D015398:Signal Transduction; D014157:Transcription Factors
D014157:Transcription Factors