A judgment of attribution of increase in urine beta 2-microglobulin after environmental cadmium exposure.
Urine beta 2-microglobulin (beta 2-m) was measured in 433 persons with low-level, long-term environmental exposure to Cd, and in 124 control persons from unpolluted area. In 152 of the exposed persons, and some of the controls, the urine beta 2-m exceeded the limit. Of the 433 exposed persons, 74 cases with both urine Cd and beta 2-m exceeding the limit were matched by the control. This study suggests that after the stratification of the degrees of renal tubular injury according to the fractional beta 2-m excretion (FE beta 2-m) and coordination of clinical examination, FE beta 2-m could contribute to identifying renal tubular dysfunction due to Cd exposure and kidney lesion when both Cd exposure and original nephropathy exist.
Cai
S
S
Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing.
Wang
J
J
Xue
J
J
Zhu
X
X
Wang
J
J
Wang
Y
Y
D000328:Adult; D002104:Cadmium / Q000009:adverse effects* / Q000652:urine; D002681:China; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000032:analysis / Q000652:urine*
D001613:beta 2-Microglobulin; D002104:Cadmium