[Imerslund-Najman-Gräsbeck anemia. Apropos of a case].
Imerslund-Najman-Gräsbeck anemia is an infrequent disease with an autosomal recessive pattern of inheritance. The characteristic anomaly is selective malabsorption of vitamin B12 by the ileal mucosa. Diagnosis rests on a positive family history and on the demonstration of megaloblastic anemia with proteinuria. The proteinuria is due to glomerular dysfunction with mesangial proliferation. Management rests on lifelong parenteral administration of vitamin B12. A case of Imerslund anemia with a favorable outcome under vitamin B12 treatment is reported.
el Bez
M
M
Service de Pédiatrie, Hôpital La Rabta, Tunis, Tunisie.
Souid
M
M
Kallel
J
J
Mebazaa
R
R
Ben Dridi
M F
MF
D000740:Anemia / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D005808:Genes, Recessive; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D013577:Syndrome; D014805:Vitamin B 12 / Q000378:metabolism / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000188:drug therapy
D014805:Vitamin B 12
L'anémie d'Imerslund-Najman-Gräsbeck. A propos d'un cas.