Cancer predisposition in Bloom's syndrome.
This article focuses upon defining those factors which may contribute to the pathogenesis of cancer. The molecular basis of tumour etiology is discussed with reference to cancer predisposing syndromes, and in particular to the human inherited disease, Bloom's syndrome. In Bloom's syndrome, patients are predisposed to a wide variety of malignant disease. We propose a model in which overexpression of the ubiquitous c-myc proto-oncogene contributes to this process.
Sullivan
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Rodent Technology Group, Animal Biotechnology Cambridge Ltd., University of Cambridge, UK.
Willis
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D001816:Bloom Syndrome / Q000235:genetics*; D004249:DNA Damage; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc; D006801:Humans; D008954:Models, Biological; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D000090063:Proto-Oncogene Mas