title: The relationship between thallium uptake, blood flow, and blood pool activity in bone and soft tissue tumors.
abstract: Twenty patients with known primary untreated and recurrent bone and soft tissue tumors underwent thallium imaging and three-phase bone imaging in the same session. The ratio of thallium uptake in the tumor tissue to the contralateral normal tissue areas was compared with the same ratio for phase 1 (blood flow or arterial phase), phase 2 (blood pool), and phase 3 (delayed medroxy-diphosphonate, MDP, uptake). There was poor correlation between Tl uptake and phases 1 and 3 of the bone scan ratios; r = 0.37 and 0.46; P = 0.097 and 0.047, respectively. The thallium uptake ratios correlated well with blood pool ratios (phase 2) (r = 0.84 and P less than 0.01). In contrast to uptake into normal muscle, Tl-201 uptake into tumor is not highly dependent on blood flow alone and other factors predominate in determining its magnitude.
authors.affiliation: Department of Medical Imaging, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: C
authors.initials: C
authors.lastname: Caluser
authors.forename: H
authors.initials: H
authors.lastname: Macapinlac
authors.forename: J
authors.initials: J
authors.lastname: Healey
authors.forename: F
authors.initials: F
authors.lastname: Ghavimi
authors.forename: P
authors.initials: P
authors.lastname: Meyers
authors.forename: N
authors.initials: N
authors.lastname: Wollner
authors.forename: J
authors.initials: J
authors.lastname: Kalaigian
authors.forename: L
authors.initials: L
authors.lastname: Kostakoglu
authors.forename: H M
authors.initials: HM
authors.lastname: Abdel-Dayem
authors.forename: S D
authors.initials: SD
authors.lastname: Yeh
mesh_terms: D001859:Bone Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D012983:Soft Tissue Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism; D013669:Technetium Tc 99m Medronate / Q000493:pharmacokinetics; D013794:Thallium Radioisotopes / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D013794:Thallium Radioisotopes; D013669:Technetium Tc 99m Medronate