title: 4-Borono-2-[18F]fluoro-D,L-phenylalanine: a possible tracer for melanoma diagnosis with PET.
abstract: The potential of 4-borono-2-[18F]fluoro-D,L-phenylalanine ([18F]FBPA), a flurodinated derivative of a target compound for boron neutron capture therapy, for melanoma imaging by positron emission tomography (PET) was studied using animal models. A high uptake of [18F]FBPA was found in murine B16 melanoma or in Greene's melanoma No. 179, a melanotic cell line in hamsters, for the first 6 h after injection. Whole body autoradiography using [18F]FBPA gave a clear image of the B16 tumor. The acid-insoluble 18F in the B16 increased to 27% by 6 h, and most of the free 18F was detected as [18F]FBPA in both B16 and plasma. In the hamster models, No. 179 showed a 1.7 times higher uptake than amelanotic Greene's melanoma No. 178 at 6 h post-injection, although both melanomas indicated similar metabolic activities when examined by a tracer uptake study using L-[14C]methionine, 2-deoxy-D-[14C]glucose and [3H]thymidine. [18F]FBPA may be a very promising PET tracer for melanoma imaging.
authors.affiliation: Division of Radiopharmaceutical Chemistry, Tohoku University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ishiwata
authors.forename: T
authors.initials: T
authors.lastname: Ido
authors.forename: C
authors.initials: C
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Ichihashi
authors.forename: Y
authors.initials: Y
authors.lastname: Mishima
mesh_terms: D000818:Animals; D001345:Autoradiography; D001896:Boron Compounds / Q000378:metabolism / Q000493:pharmacokinetics; D002250:Carbon Radioisotopes; D006224:Cricetinae; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D008546:Melanoma, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D008647:Mesocricetus; D051379:Mice; D009368:Neoplasm Transplantation; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods; D014407:Tumor Cells, Cultured; D014915:Whole-Body Counting
chemical_list: D001896:Boron Compounds; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; C072915:4-borono-2-fluorophenylalanine; D010649:Phenylalanine; D003847:Deoxyglucose