Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants.
The development of buthionine sulfoximine, a selective inhibitor of glutathione biosynthesis, is an important new tool to elucidate the in vivo role of glutathione. Recent investigations have shown that ascorbic acid can serve as an essential antioxidant in the presence of severe glutathione deficiency.
Broquist
H P
HP
Biotechnology Center, Utah State University, Logan 84322-4705.
D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D019328:Buthionine Sulfoximine; D004195:Disease Models, Animal; D005978:Glutathione / Q000172:deficiency / Q000502:physiology*; D008717:Methionine Sulfoximine / Q000031:analogs & derivatives*; D051381:Rats
D000975:Antioxidants; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D001205:Ascorbic Acid