Carcinogenicity testing of some constituents of black pepper (Piper nigrum).
In mice, injection of safrole, tannic acid or methylcholanthrene (MCA) during the preweaning period induced tumors in different organs. Safrole and tannic acid (constituents of black pepper) were weak carcinogens when compared with MCA which was used as a carcinogenic control substance. Force feeding of d-limonene (one of the pepper terpenoids) for a long time to the mice which were injected with any of the above 3 substances reduced their carcinogenic activity, while force feeding of piperine (one of black pepper alkaloids) was ineffective.
Wrba
H
H
Vienna University, Institute of Applied and Experimental Oncology, Austria.
el-Mofty
M M
MM
Schwaireb
M H
MH
Dutter
A
A
D000470:Alkaloids; D000818:Animals; D052117:Benzodioxoles; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D003212:Condiments / Q000633:toxicity*; D053138:Cyclohexenes; D005260:Female; D047348:Hydrolyzable Tannins / Q000633:toxicity*; D000077222:Limonene; D008297:Male; D051379:Mice; D010880:Piperidines / Q000633:toxicity*; D053284:Polyunsaturated Alkamides; D012451:Safrole / Q000633:toxicity*; D013729:Terpenes / Q000633:toxicity*
D000470:Alkaloids; D052117:Benzodioxoles; D002273:Carcinogens; D053138:Cyclohexenes; D047348:Hydrolyzable Tannins; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D013729:Terpenes; D000077222:Limonene; D012451:Safrole; C008922:piperine