Primary phase of hepatocytic autophagocytosis under ischaemic conditions.
Increased autophagocytosis in hepatocytes was found in response to conditions of ischaemia/hypoxia. Initial stages proved to be recordable. These were found to become manifest through the formation of phospholipid membrane structures, approximately 5 nm in width, coalescing in circular formations with vesicular extensions. They may further develop to form multilayer myelin structures. Enveloped cytoplasmic regions and organelles were unchanged, at the beginning, and subsequently coalesced typically into autophagolysosomes and autophagic vacuoles. Verification will be necessary to find out if these initial stages occur only in response to hypoxia or constitute a phenomenon of general validity.
David
H
H
Humboldt University, Charité Hospital, Institute of Pathology, Berlin, Germany.
Ellermann
J
J
Uerlings
I
I
D000818:Animals; D001343:Autophagy / Q000502:physiology*; D006801:Humans; D007511:Ischemia / Q000473:pathology*; D008099:Liver / Q000098:blood supply* / Q000166:cytology / Q000648:ultrastructure