title: Changes in alkaline phosphatase and 5'-nucleotidase multiple forms after surgical management of biliary obstruction.
abstract: Serial measurements of alkaline phosphatase and 5'-nucleotidase multiple forms in two patients undergoing surgical procedures to release biliary obstruction suggested an inverse relationship between high-M(r) isoforms and serum bile acids concentrations. Furthermore, the study of several groups of patients with cholestatic disorders confirmed this inverse correlation. Mechanisms responsible for these observations are discussed.
authors.affiliation: Laboratorio Central, Hospital General de Galicia, Santiago de Compostela, Spain.
authors.forename: F J
authors.initials: FJ
authors.lastname: Novo
authors.forename: J C
authors.initials: JC
authors.lastname: Tutor
mesh_terms: D015720:5'-Nucleotidase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D002779:Cholestasis / Q000201:enzymology / Q000601:surgery*; D006801:Humans; D007527:Isoenzymes / Q000097:blood*
chemical_list: D007527:Isoenzymes; D000469:Alkaline Phosphatase; D015720:5'-Nucleotidase