Failed oocyte retrieval after lack of human chorionic gonadotropin administration in assisted reproductive technology.
OBJECTIVE
To document the absence of oocytes in follicular aspirates in women who, during controlled ovarian stimulation with gonadotropin-releasing hormone agonist (GnRH-a) and menotropins, fail to receive human chorionic gonadotropin (hCG) administration.


METHODS
Retrospective analysis of clinical laboratory data.


METHODS
Multicentric.


METHODS
Five women undergoing controlled ovarian hyperstimulation with GnRH-a and menotropins for programs of assisted reproductive technologies.


RESULTS
The documented absence of an hCG injection produced "empty follicles" at transvaginal guided aspiration, despite numerous follicular lavages and aspiration of peritoneal fluid. The lack of oocytes and granulosa-cumulus complex in the follicular fluid was reverted in other cycles in the same patients when hCG was properly administered.


CONCLUSIONS
(1) This study emphasizes the importance of proper patients' and nurses' instructions for preparation of hCG injections and proper mixture of vehicle and powder before follicular aspiration. (2) In the absence of cumulus-corona-oocyte complex at aspiration, measure serum beta-hCG to ascertain whether hCG injection was administered or not. (3) Routine preoperative beta-hCG levels may be helpful to avoid unnecessary surgeries.
Asch
R H
RH
University of California-Irvine, Department of Obstetrics and Gynecology, UCI Center for Reproductive Health, Orange 92668.
Li
H P
HP
Yovich
J L
JL
Katayama
K P
KP
Balmaceda
J P
JP
Rojas
F J
FJ
Stone
S C
SC
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage* / Q000627:therapeutic use; D004624:Embryo Transfer; D005187:Fallopian Tubes; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D008596:Menotropins / Q000627:therapeutic use; D009865:Oocytes / Q000166:cytology*; D012099:Reproductive Techniques; D012189:Retrospective Studies; D013396:Suction; D007507:Therapeutic Irrigation; D015053:Zygote
D006063:Chorionic Gonadotropin; D008596:Menotropins; D005640:Follicle Stimulating Hormone; D016729:Leuprolide