In vivo studies of unlabeled and radioiodinated rhodamine-123.
Radioiodinated rhodamine-123 (Rh123), potential tumor imaging agent, was injected in mice bearing experimentally-induced tumors to investigate its tissue distribution. Some accumulation of radioactivity was found in tumors; most of it cleared rapidly from the blood after injection. Also, the radioiodinated Rh123 had metabolized to water-soluble species which was excreted in urine and feces. Unlabeled Rh123, on the other hand, accumulated only marginally in the tumors. However, it was found to accumulate significantly in the heart; as much as seventy times the level in blood at 4 h post-injection. Accumulation of unlabeled Rh123 increased steadily even at 24 h post-injection; whereas, it cleared rapidly from the blood via the kidney. This finding of selective accumulation of Rh123 in heart could be exploited in synthesizing 11C- and 18F-labeled Rh123 for use in PET studies of the myocardium.
Vora
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Radionuclide and Cyclotron Operations Department, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
Dhalla
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D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007457:Iodine Radioisotopes / Q000378:metabolism / Q000493:pharmacokinetics*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008929:Mitochondria, Heart / Q000378:metabolism; D009368:Neoplasm Transplantation; D020112:Rhodamine 123; D012235:Rhodamines / Q000378:metabolism / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
D007457:Iodine Radioisotopes; D012235:Rhodamines; D020112:Rhodamine 123