title: [Screening for alpha 1-antitrypsin deficiency in neonates].
abstract: In a two-year investigation 113,274 children were screened for alpha-1-antitrypsin deficiency. An original and cheap method was used. In children with an alpha-1-antitrypsin values lower than 1.5 g/l the phenotype was assessed. In 120 neonates alpha-1-antitrypsin was assessed by screening and also quantitatively. The physiological range of alpha-1-antitrypsin for neonates is: 1.4-3.32 g/l. A low incidence of alpha-1-antitrypsin in the Czechoslovak population, as compared with investigations abroad, was revealed. The authors discuss the possibility to extend screening from the clinical, ethical and economic aspect to the entire republic.
authors.affiliation: Výzkumný ústav zdraví dítĕte, Brno.
authors.forename: M
authors.initials: M
authors.lastname: Durpektová
authors.forename: L
authors.initials: L
authors.lastname: Kozák
authors.forename: A
authors.initials: A
authors.lastname: Mrskos
authors.forename: J
authors.initials: J
authors.lastname: Kamarýt
authors.forename: J
authors.initials: J
authors.lastname: Snopková
authors.forename: A
authors.initials: A
authors.lastname: Pijácková
authors.forename: J
authors.initials: J
authors.lastname: Starha
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening; D010641:Phenotype; D019896:alpha 1-Antitrypsin Deficiency
vernacular_title: Screening deficitu alfa-1-antitrypsinu v novorozeneckém vĕku.