title: [Molecular biological study on the overexpression of c-myc gene in uterine cervical carcinomas].
abstract: The expression of mRNA for c-myc gene was investigated in 30 cases of human uterine cervical carcinoma by Northern blot hybridization, and c-myc gene amplification was also examined by Slot blot hybridization. Overexpression of c-myc gene was detected in one (7.7%) of 13 cases of carcinoma in situ (stage 0), one (10.0%) of 10 stage I and 4 (57.1%) of 7 stage II uterine carcinoma, and c-myc gene amplification was detected in 2 cases (6.7%) in which c-myc gene overexpression was also found. The patient whose c-myc mRNA level was more than 10 times as high as in normal uterine cervical tissue relapsed and died within 2 years after the first treatment. Our results suggest that the overexpression of c-myc gene occurred more frequently in advanced than in early uterine cervical carcinoma and that it might be useful in prognosing cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Hiroshima University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Tanimoto
authors.forename: N
authors.initials: N
authors.lastname: Nagai
authors.forename: H
authors.initials: H
authors.lastname: Fujimoto
authors.forename: S
authors.initials: S
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Ohama
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D015870:Gene Expression; D016259:Genes, myc; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
chemical_list: D012333:RNA, Messenger