Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
We have used panels of somatic cell hybrids and fluorescent in situ hybridization to determine the chromosomal localization of the novel nontransmembrane tyrosine phosphatase PTPN6 (protein tyrosine phosphatase, nonreceptor type 6), which contains two SH2 domains. PTPN6 maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. Since PTPN6 is expressed at high levels in hematopoietic cells of all lineages and its expression is induced early in hematopoietic differentiation, altered expression and/or structure of PTPN6 may play a role in leukemogenesis.
Plutzky
J
J
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215.
Neel
B G
BG
Rosenberg
R D
RD
Eddy
R L
RL
Byers
M G
MG
Jani-Sait
S
S
Shows
T B
TB
D000595:Amino Acid Sequence; D001483:Base Sequence; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D004247:DNA / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000235:genetics*; D013438:Sulfhydryl Compounds / Q000737:chemistry
D013438:Sulfhydryl Compounds; D004247:DNA; D017027:Protein Tyrosine Phosphatases