[Combined therapy with 5-FU and levamisole].
Levamisole, which had been used as an insecticide for more than 20 years, was reported to have anticancer effects as an immunopotentiator. Among many clinical trials with this agent, Moertel and his colleagues reported excellent results in Dukes-C colon cancer patients treated with 5-FU and levamisole in 1990. In this paper, results of our animal experiments would be reported in conjunction with the review of the recent clinical trials.
Mitomi
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T
Department of Surgery, Tokai University School of Medicine, Isehara, Japan.
Noto
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T
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007978:Levamisole / Q000008:administration & dosage; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality
D000276:Adjuvants, Immunologic; D007978:Levamisole; D005472:Fluorouracil