[Pathological study of malignant peripheral nerve sheath tumor in rat].
Sequential morphological studies of rat malignant peripheral nerve sheath tumors induced with ethylnitrosourea were performed by light microscopy, transmission electron microscopy, scanning electron microscopy, immunohistochemistry and nude mice transplantation. The result indicated that rat malignant peripheral nerve sheath tumor was actually a sarcoma arising from Schwann cell within the peripheral nerve, which possesses some basic morphological characteristics as those of human malignant peripheral nerve sheath tumor, and is considered worthy to be used as a model for further studies.
Huang
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Y
Department of Pathology, West China University of Medical Sciences, Chengdu.
D000818:Animals; D005038:Ethylnitrosourea; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009442:Neurilemmoma / Q000139:chemically induced / Q000473:pathology* / Q000648:ultrastructure; D010524:Peripheral Nervous System Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D005038:Ethylnitrosourea