title: Blood pressure reduction during hemodialysis correlates to intradialytic changes in plasma volume.
abstract: Blood pressure alterations during hemodialysis were related to changes in body fluid in 14 patients with chronic renal failure. Changes in plasma volume (PV) and extracellular volume (ECV) were calculated from determinations of fluid volumes before and after hemodialysis, using 125I-albumin and 51Cr EDTA respectively. Reduction in body water was estimated from body weight changes. Weight loss was 3.3 +/- 0.3 kg (range 1.8-6.0 kg). The relative reduction of fluid was greater in the ECV, 21.6 +/- 3.2%, compared to plasma volume, 6.9 +/- 1.8%. The reduction in systolic blood pressure was related to both absolute (r = 0.66, p less than 0.05) and relative PV reduction (r = 0.72, p less than 0.02). There was no correlation between blood pressure reduction and weight loss or ECV changes. Only minor alterations were found in diastolic blood pressure. Plasma volume maintenance relates to blood pressure changes. Plasma volume monitoring could be useful for improving intradialytic hemodynamic control.
authors.affiliation: Department of Medicine, Karolinska Institute and Hospital, Stockholm, Sweden.
authors.forename: L E
authors.initials: LE
authors.lastname: Lins
authors.forename: G
authors.initials: G
authors.lastname: Hedenborg
authors.forename: S H
authors.initials: SH
authors.lastname: Jacobson
authors.forename: K
authors.initials: K
authors.lastname: Samuelson
authors.forename: B
authors.initials: B
authors.lastname: Tedner
authors.forename: U B
authors.initials: UB
authors.lastname: Zetterholm
authors.forename: O
authors.initials: O
authors.lastname: Ljungqvist
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D001825:Body Fluid Compartments / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010953:Plasma Volume / Q000502:physiology*; D006435:Renal Dialysis