Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease.
The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of hypercalcaemia, using an immunohistochemical staining technique for PTHRP on the tumour tissue and an immunoradiometric (IRMA) assay for PTHRP1-86 on the patient's plasma. The plasma PTHRP was less than 0.23 pmol/l in the range found in normocalcaemic controls, and the immunohistochemical staining was not positive for protein. PTHRP did not have a role in the pathogenesis of hypercalcaemia in this patient.
Bolo-Deoku
J
J
Department of Chemical Pathology & Metabolism, St Helier Hospital, Carshalton, Surrey.
Basu
S
S
Lakhani
S
S
Dunne
F
F
Ratcliffe
W A
WA
Clarke
M
M
Barron
J L
JL
D000368:Aged; D006689:Hodgkin Disease / Q000150:complications* / Q000378:metabolism; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology* / Q000378:metabolism; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis*; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments / Q000494:pharmacology; D011506:Proteins / Q000032:analysis* / Q000494:pharmacology
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D010446:Peptide Fragments; D011506:Proteins; C054296:parathyroid hormone-related protein (1-34)