Recurrence of myomas after myomectomy in women pretreated with leuprolide acetate depot or placebo.
The recurrence of myomas and myoma-related symptoms was evaluated in women participating in a randomized, double-blind, P-controlled study of the efficacy of LA depot before myomectomy. After 27 to 38 months of follow-up, the recurrence of myomas was found to be greater when at least four myomas were resected. Myoma recurrence was not associated with pretreatment or preoperative uterine volume, resected myoma mass, or preoperative medical therapy.
Friedman
A J
AJ
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Daly
M
M
Juneau-Norcross
M
M
Fine
C
C
Rein
M S
MS
D000328:Adult; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D016729:Leuprolide / Q000008:administration & dosage / Q000627:therapeutic use*; D009214:Myoma / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery*; D012008:Recurrence; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000453:epidemiology* / Q000601:surgery
D003692:Delayed-Action Preparations; D016729:Leuprolide