title: Variations of homovanillic acid levels in ventricular cerebrospinal fluid.
abstract: We studied the nycterohemeral variations of homovanillic acid (HVA) in ventricular cerebrospinal fluid (CSF) in 24 patients undergoing monitoring of intracranial pressure as part of the normotensive hydrocephalus (NTH) work-up. CSF samples were obtained every 4 h in each patient. The mean individual values of HVA in the ventricular CSF ranged from 133 to 421 ng/ml, and they could not be correlated to any clinical feature. The intraindividual levels of HVA were stable throughout 24 hours, with a variation coefficient inferior to 10% in 63% of cases, and inferior to 20% in all the patients.
authors.affiliation: Neurology Service, Erasmus Hospital, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Hildebrand
authors.forename: Z
authors.initials: Z
authors.lastname: Moussa
authors.forename: C
authors.initials: C
authors.lastname: Raftopoulos
authors.forename: J
authors.initials: J
authors.lastname: Vanhouche
authors.forename: M A
authors.initials: MA
authors.lastname: Laute
authors.forename: S
authors.initials: S
authors.lastname: Przedborski
mesh_terms: D000368:Aged; D015306:Biogenic Monoamines / Q000378:metabolism; D002552:Cerebral Ventricles / Q000098:blood supply*; D005260:Female; D005684:Gait; D006719:Homovanillic Acid / Q000032:analysis* / Q000134:cerebrospinal fluid; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014549:Urinary Incontinence
chemical_list: D015306:Biogenic Monoamines; D006719:Homovanillic Acid