title: Effects of multiple injections of HCG on testis blood flow.
abstract: In attempting to determine whether or not multiple injections of human chorionic gonadotropin (hCG) augment testis blood flow, adult male rats were injected with three doses of 10 IU of hCG every other day and testis blood flow was determined on day 5, the day of the final injection. Testis blood flow (mL/100 g testis tissue/min +/- SEM) as measured by the 133Xe washout method increased from 10.8 +/- 1.3 to 20.4 +/- 4.5 (p less than 0.05) after the three doses of hCG. These observations suggest that multiple injections of hCG appear to have the same effect as a single dose of hCG in increasing testis blood flow. This supports the hypothesis that hCG should be administered to all patients undergoing orchiopexy in the hope that the increased perfusion of the gonad will make it less susceptible to ischemia during the surgical procedure.
authors.affiliation: Department of Surgery, UCLA School of Medicine, Torrance.
authors.forename: B
authors.initials: B
authors.lastname: Geesaman
authors.forename: J
authors.initials: J
authors.lastname: Villanueva-Meyer
authors.forename: D
authors.initials: D
authors.lastname: Bluestein
authors.forename: L
authors.initials: L
authors.lastname: Miller
authors.forename: I
authors.initials: I
authors.lastname: Mena
authors.forename: J
authors.initials: J
authors.lastname: Rajfer
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects; D013268:Stimulation, Chemical; D013737:Testis / Q000098:blood supply* / Q000000981:diagnostic imaging; D014980:Xenon Radioisotopes
chemical_list: D006063:Chorionic Gonadotropin; D014980:Xenon Radioisotopes