title: [Changes in the blood coagulation and fibrinolysis system in the course of normal pregnancy].
abstract: In the present study we investigated several factors of hemostasis and fibrinolysis during the normal pregnancy in 52 women. Whereas the Thrombin-Time did not show any change, the increase of the Hepato-Quick and the decrease of the Partial Thromboplastin-Time was significant. During pregnancy we observed a significant increase of the activity of fibrinogen, factor XII and prekallikrein as well as of the von-Willebrand-factor-antigen (VIIIR:Ag). The activity of factor II and X remained constantly. The increased activity of factors of hemostasis was accompanied by an increase of activity and concentration of antithrombin-III. In contrast to the activity of the hemostatic system we could not find any significant alteration of the fibrinolytic system. The cause must be searched in the observed increase of plasminogen-activator-inhibitor (PAI)--likly in combination with a decrease of the tissue-type plasminogen activator (t-PA). Our data indicate, that the highest risk for thrombosis already might exist in week 24 of pregnancy, because a distinct increase of hemostatic activity is combined with a nearly unchanged fibrinolytic activity.
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe Medizinischen Akademie Carl Gustav Carus Dresden.
authors.forename: B
authors.initials: B
authors.lastname: Justus
authors.forename: G
authors.initials: G
authors.lastname: Siegert
authors.forename: O
authors.initials: O
authors.lastname: Tiebel
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology*; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D008137:Longitudinal Studies; D010314:Partial Thromboplastin Time; D011247:Pregnancy / Q000097:blood*; D011517:Prothrombin Time; D012016:Reference Values
vernacular_title: Veränderungen im Gerinnungs- und Fibrinolysesystem während des Verlaufs der normalen Schwangerschaft.