TMB-8 (8-(N,N-diethylamino) octyl-3,4,5-trimethoxybenzoate) inhibits the ATP-sensitive K+ channel.
Whole-cell current clamp, single-channel recordings and 86Rb+ flux techniques have been used to show that 8-(N,N-diethyl-amino)octyl-3,4,5-trimethoxybenzoate (TMB-8) inhibits ATP-sensitive K+ channels in HIT-T15 beta-cells. TMB-8 inhibition is observed when KATP channels are activated by ATP depletion or by the K+ channel opener, diazoxide.
Szewczyk
A
A
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.
De Weille
J R
JR
Lazdunski
M
M
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003981:Diazoxide / Q000494:pharmacology; D004594:Electrophysiology; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D007340:Insulinoma / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects*; D012414:Rubidium Radioisotopes; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D002121:Calcium Channel Blockers; D015221:Potassium Channels; D012414:Rubidium Radioisotopes; C006014:8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate; D005707:Gallic Acid; D000255:Adenosine Triphosphate; D003981:Diazoxide