title: [Prophylactic administration of glucocorticoids prior to microlaryngoscopies?].
abstract: Intravenous glucocorticoids before direct laryngoscopy? The necessity of a preventive injection of corticoids before direct laryngoscopy was determined in a prospective, double blind study. 51 patients, who underwent direct laryngoscopy under general anaesthesia, received either 250 mg methylprednisolone in 10 ml NaCl 0.9% (corticoid group) or 10 ml NaCl (NaCl group) intravenously one hour before laryngoscopy. Oedema formation and the degree of inflammation in the pharynx and hypopharynx were examined on the day prior to surgery and three to four hours postoperatively. Complications of the airways were noted in the immediate postoperative phase and at the time of the second examination. Direct laryngoscopy did not induce any significant change in oedema formation or degree of inflammation in both groups. However, there was a correlation between the duration of surgery and the degree of increase in oedema and inflammation in the NaCl group but not in the corticoid group. No difference between the groups was noted with regard to postoperative complications of the airways. Based on the present study, routine application of corticoids to prevent oedema after direct laryngoscopy cannot be recommended.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin der Westfälischen Wilhelms-Universität Münster.
authors.forename: H M
authors.initials: HM
authors.lastname: Loick
authors.forename: R
authors.initials: R
authors.lastname: Höing
authors.forename: C
authors.initials: C
authors.lastname: Anger
authors.forename: G
authors.initials: G
authors.lastname: Brodner
authors.forename: J L
authors.initials: JL
authors.lastname: Theissen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D004487:Edema / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007013:Hypopharynx; D007249:Inflammation / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D007275:Injections, Intravenous; D007828:Laryngoscopy / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010608:Pharyngeal Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D010612:Pharyngitis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies
chemical_list: D008775:Methylprednisolone
vernacular_title: Prophylaktische Glukokortikoidgabe vor Mikrolaryngoskopien?