[CML with autoimmune thrombocytopenia observed in the course of IgG (kappa) type monoclonal gammopathy].
An 80-year-old male with IgG (kappa) type benign monoclonal gammopathy was admitted to our hospital because of marked leukocytosis. At the time of admission, thrombocytopenia was also noted. A bone marrow aspirate showed marked granulocytosis with a normal megakaryocyte count. PAIgG was elevated and the NAP score was low. Ph1 chromosome and rearrangement of the breakpoint cluster region were detected. On the basis of these findings, he was diagnosed as having CML with autoimmune thrombocytopenia. This case was of interest with respect to blood cell differentiation and immunological findings.
Nakase
T
T
Department of Internal Medicine, Kyoto Yawata Hospital.
Matsuoka
N
N
Iwasaki
E
E
Ukyo
S
S
Shirakawa
S
S
D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000209:etiology*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008297:Male; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology; D013921:Thrombocytopenia / Q000209:etiology*
D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains