Effect of diazepam on the fatty acid composition of plasma and liver phospholipids in rat.
Male Wistar rats (2 months old) were maintained on a nutritionally adequate diet, and diazepam was administered at a dose of 10 mg/kg/day. After 24 weeks the effects on the fatty acid composition of plasma and liver phospholipids were studied. Increased levels of palmitic (16:0), palmitoleic (16:1n-7), stearic (18:0), and oleic (18:1n-9) acids were found in plasma phospholipids. In contrast, the levels of docosapentanoic (22:5n-3) and docosahexanoic (22:6n-3; DHA) acids were drastically decreased by diazepam. A significant decrease produced by diazepam was also found in levels of DHA in liver phospholipids.
Ristić
V
V
Institute for Medical Research, Beograd, Yugoslavia.
Vrbaski
S R
SR
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis*; D008099:Liver / Q000737:chemistry* / Q000187:drug effects; D008297:Male; D010743:Phospholipids / Q000032:analysis* / Q000097:blood / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D010743:Phospholipids; D003975:Diazepam