Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes.
A series of cis-bis-(2-chloroethylamine)platinum(II) and platinum(IV) complexes were synthesized and characterized by elemental analysis, IR, and 1H and 195Pt NMR spectroscopic techniques. Complexes were tested in vitro against murine L1210 leukemia and human ovarian A2780 cell lines and in vivo against the L1210 leukemia model. Some of these complexes showed excellent antitumor activity in both systems. However, all were inactive against cisplatin-resistant A2780/CP cells.
Khokhar
A R
AR
Department of Medical Oncology, University of Texas, M. D. Anderson Cancer Center, Houston 77030.
Xu
Q
Q
Newman
R A
RA
Kido
Y
Y
Siddik
Z H
ZH
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D010051:Ovarian Neoplasms; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D009944:Organoplatinum Compounds