Effect of pine seed shell extract on microbial and viral infection.
Pretreatment of mice with ammonia extract of seed shell of Pinus Koraicenis, via the intraperitoneal or intravenous route, effectively protected them from lethal infection of Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. The pine seed shell extract also moderately inhibited syncytium formation and cytopathogenic effect induced by human immunodeficiency virus (HIV) infection in cultured human lymphotropic virus type I (HTLV-1) positive MT-4 cells. These data suggest a medicinal potential of pine seed shell extract against opportunistic infection in HIV patients.
Sakagami
H
H
First Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
Yoshihara
M
M
Fujimaki
M
M
Wada
C
C
Komatsu
N
N
Nakashima
H
H
Murakami
T
T
Yamamoto
N
N
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002177:Candidiasis / Q000517:prevention & control*; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000517:prevention & control*; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000517:prevention & control*; D015490:HTLV-I Infections / Q000517:prevention & control*; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007564:Japan; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012639:Seeds; D013045:Species Specificity; D013203:Staphylococcal Infections / Q000517:prevention & control*; D014197:Trees
D000900:Anti-Bacterial Agents; D010936:Plant Extracts