PROBIT: a statistical approach to modeling proteins from partial coordinate data using substructure libraries.
A program (PROBIT) has been developed that allows the reconstruction of a complete set of three-dimensional protein coordinates from alpha-carbon coordinates. The program generates a statistical measure of polypeptide conformational behavior for substructures in a defined structural context from a library of highly refined protein structures. These statistics provide a prescription for substructure substitution from the database to allow regeneration of the complete protein structure.
Wendoloski
J J
JJ
Du Pont Merck Pharmaceutical Company, Wilmington, DE 19880-0228.
Salemme
F R
FR
D003198:Computer Simulation; D008958:Models, Molecular; D015233:Models, Statistical; D011487:Protein Conformation; D012984:Software; D014961:X-Ray Diffraction