Dermal exposure of hexachlorophene to guinea pigs.
The skins of guinea pigs were exposed to 50 mg/kg hexachlorophene (HCP) for 7, 15 or 30 days. The activities of skin marker enzymes (beta-glucuronidase, histidase, tyrosinase) increased, but glutathione decreased. Lipid peroxidation and histamine contents increased during different time intervals. The histopathological changes showed damage to epidermis and dermis. Depending on the duration of exposure, HCP produces biochemical and histopathological damage to skin.
Mathur
A K
AK
Industrial Toxicology Research Centre, Lucknow, India.
Gupta
B N
BN
Shanker
R
R
Narang
S
S
Singh
S
S
Singh
A
A
D000818:Animals; D004817:Epidermis / Q000473:pathology; D005966:Glucuronidase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006168:Guinea Pigs; D006582:Hexachlorophene / Q000633:toxicity*; D006638:Histidine Ammonia-Lyase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D014442:Monophenol Monooxygenase / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology
D014442:Monophenol Monooxygenase; D005966:Glucuronidase; D006638:Histidine Ammonia-Lyase; D005978:Glutathione; D006582:Hexachlorophene