Immune system of the spontaneously hypertensive rat. I. Sympathetic innervation.
Extensive bidirectional interactions are believed to exist between the sympathetic nervous system and the immune system. The spontaneously hypertensive rat (SHR) is known to possess both increased sympathetic nervous system activity with increased tissue catecholamine levels in several peripheral organs and a moderate T lymphocyte immune deficiency. We examined the development of innervation in both primary (thymus) and secondary (spleen) organs of the immune system of the SHR compared to immunocompetent Wistar-Kyoto (WKY), Fisher 344 (F-344), and Long Evan (LE) rats from birth through 24 weeks. Using glyoxylic acid-induced histofluorescence to visualize monoaminergic nerve fibers, coded specimens were examined and morphologically evaluated for the extent and distribution of innervation. The innervation of the SHR thymus was significantly increased at 2 and 12 weeks of age over the other strains. Unlike the control strains, splenic innervation in SHR was delayed until 2 weeks of age when it suddenly became exuberant. At 12 weeks, the innervation of the SHR spleen was increased over all control strains. By 24 weeks the innervation had regressed to a level comparable to the levels of the other rat strains in these tissues. During the suckling period, the size (weight) of the WKY spleen was larger and the level of innervation was decreased compared to the other strains. These strain-related differences in the development of sympathetic innervation of thymus and spleen likely reflect the complex, bidirectional interplay between the nervous and the immune systems.(ABSTRACT TRUNCATED AT 250 WORDS)
Purcell
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ES
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160.
Gattone
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VH
D000375:Aging; D000818:Animals; D001835:Body Weight; D007107:Immune System / Q000294:innervation*; D008297:Male; D009412:Nerve Fibers / Q000502:physiology / Q000648:ultrastructure; D009929:Organ Size; D051381:Rats; D011916:Rats, Inbred F344 / Q000276:immunology; D011917:Rats, Inbred Lew / Q000276:immunology; D011918:Rats, Inbred SHR / Q000276:immunology*; D011921:Rats, Inbred WKY / Q000276:immunology; D013045:Species Specificity; D013154:Spleen / Q000033:anatomy & histology / Q000254:growth & development / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000166:cytology / Q000254:growth & development / Q000502:physiology*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000254:growth & development / Q000294:innervation*