title: [Primary arterial hypertension. Treatment with captopril and function of the left heart ventricle, concentration of catecholamine in blood and activity of renin].
abstract: We evaluated the effect of captopril treatment on left ventricular mass (LVM) and function in sustained mild-to-moderate primary hypertension. In 16 men aged 34.5 +/- 6.4 yrs. M-mode echo and pulsed wave Doppler recordings were obtained prior to and after 2 months captopril treatment (50-150 mg daily). No significant changes in heart rate, systolic blood pressure, ejection fraction, fractional shortening, cardiac output, LVM and Doppler-derived indices of mitral inflow were observed. Diastolic blood pressure measured during examination fell from 102.2 +/- 13.3 to 90.3 +/- 9 mmHg (p less than 0.026). No consistent correlations between catecholamines and indexes of left ventricular function were found. Two-month captopril therapy in mild-to-moderate hypertension results in diastolic blood pressure lowering with no effect on LVM or left ventricular function.
authors.affiliation: Kliniki Nadciśnienia Tetniczego i Chorób Naczyń Instytutu Chorób Wewnetrznych Akademii Medycznej, Warszawie.
authors.forename: A
authors.initials: A
authors.lastname: Kuch-Wocial
authors.forename: Z
authors.initials: Z
authors.lastname: Miśkiewicz
authors.forename: T
authors.initials: T
authors.lastname: Pasierski
authors.forename: M
authors.initials: M
authors.lastname: Lapiński
authors.forename: A
authors.initials: A
authors.lastname: Januszewicz
authors.forename: K
authors.initials: K
authors.lastname: Stepniakowski
authors.forename: J
authors.initials: J
authors.lastname: Chodakowska
authors.forename: W
authors.initials: W
authors.lastname: Januszewicz
authors.forename: B
authors.initials: B
authors.lastname: Wocial
authors.forename: B
authors.initials: B
authors.lastname: Dabrowska
mesh_terms: D000328:Adult; D002216:Captopril / Q000627:therapeutic use*; D002395:Catecholamines / Q000097:blood*; D015150:Echocardiography, Doppler; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D012083:Renin / Q000378:metabolism*; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D002395:Catecholamines; D002216:Captopril; D012083:Renin
vernacular_title: Pierwotne nadcśnienie tetnicze. leczenie kaptoprylem a czynność lewej komory serca, stezenie katecholamin we krwi i aktywność reniny.