The humoral immune response to heat shock proteins.
Humoral immune reactions to heat shock proteins (hsp) from microorganisms are one aspect of microbial infections in humans. The production of antibodies which are specific to epitopes present on procaryotic hsp leads also to the appearance of cross-reactive serum antibodies in the host organism that react with human hsp. This article discusses the consequences of such autoreactive antibodies for the host in context with the development of immune tolerance and autoimmune diseases, especially rheumatoid arthritis (RA), and in experimental animal models for arthritis such as adjuvant arthritis in rats. On the basis of epitope cross-reactivity between hsp and other host proteins, a hypothesis is presented for the development of autoimmune disease following the production of hsp-specific antibodies.
Mollenhauer
J
J
Institute of Pharmacology and Toxicology, University of Erlangen-Nürnberg, Germany.
Schulmeister
A
A
D000818:Animals; D000917:Antibody Formation; D001169:Arthritis, Experimental / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology; D003429:Cross Reactions; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D012216:Rheumatic Diseases / Q000276:immunology
D006360:Heat-Shock Proteins