[Depressor effect of nucleus arcuatus stimulation in chronic stress-induced hypertensive rat].
Hypertension was induced by chronic foot-shock and noise stress in adult male Sprague-Dawley rats. Microinjection of 0.3 microliters (150 mmol) sodium glutamate (Glu) into the nucleus arcuatus (ARC) elicited a significant depressor effect in rats with chronic stress-induced hypertension. The depressor effect induced by excitation of ARC neurons was attenuated significantly by microinjection of 0.3 microliters beta-endorphin antiserum (beta-EPAS) into the dorso-medial periaqueductal gray (PAG) or 0.1 microliters into the area of locus coeruleus (LC) due to blockage of beta-endorphinergic fibres from ARC to PAG or LC.
Lj
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ZS
Department of Physiology, Zhanjiang Medical College.
Liu
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D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000503:physiopathology*; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007106:Immune Sera; D008125:Locus Coeruleus / Q000503:physiopathology; D008297:Male; D008845:Microinjections; D010487:Periaqueductal Gray / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology; D013312:Stress, Physiological / Q000150:complications*; D001615:beta-Endorphin / Q000276:immunology
D007106:Immune Sera; D001615:beta-Endorphin; D012970:Sodium Glutamate