[The combined stimulation test sulpiride-TRH in the investigation of prolactin secretion].
We have studied the response of prolactin (PRL) secretion to the test combining i.m. sulpiride in the dose 1 mg/kg followed by 200 micrograms i.v. of TRH, in 12 normal women and 37 patients with hyperprolactinaemia. The response was expressed as a percentage rise in plasma PRL concentration (delta %) 20 minutes after the administration of sulpiride or TRH. In the controls the response in PRL secretion to sulpiride worked out at between 639 and 2,760%. When there was a pituitary adenoma or supra-sellar lesion the PRL response to sulpiride was always less than 481%. On the other hand the PRL response with TRH after sulpiride was not significantly different as between the controls (less than 175%) and the patients (less than 91%). We conclude: 1) the combined sulpiride and TRH test is useless for assessing hyperprolactinaemia; 2) the sulpiride test on the other hand makes it possible to show that hyperprolactinaemia cannot be stimulated and to suspect the presence in this case of a prolactin producing adenoma or a supra-sellar tumour.
Miras-Mirakian
P
P
Laboratoire de la Clinique endocrinologique, Hôpital de l'Antiquaille, Lyon.
Claustrat
F
F
Dechaud
H
H
Pugeat
M
M
D000236:Adenoma / Q000150:complications; D000568:Amenorrhea / Q000209:etiology; D002985:Clinical Protocols / Q000592:standards; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D005687:Galactorrhea / Q000209:etiology; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood* / Q000209:etiology; D007247:Infertility, Female / Q000209:etiology; D010911:Pituitary Neoplasms / Q000150:complications; D011388:Prolactin / Q000097:blood* / Q000378:metabolism; D015203:Reproducibility of Results; D013469:Sulpiride / Q000008:administration & dosage; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage
D013973:Thyrotropin-Releasing Hormone; D013469:Sulpiride; D011388:Prolactin
Le test de stimulation combiné sulpiride-TRH dans l'exploration de la sécrétion de la prolactine.