Bilateral thalamic glioma: review of eight cases with personality change and mental deterioration.
OBJECTIVE
To describe the clinical, radiographic, and neuropathologic features of bilateral thalamic glioma.


METHODS
We searched our hospital records (1963 to present) to identify patients diagnosed as having the disease.


RESULTS
Our search revealed eight patients, ranging in age from 8-63 years, with bithalamic tumor diagnosed by angiography, CT, and/or MR. All patients displayed personality changes and/or mental deterioration, including memory loss, inattention, confusion, hallucination, hyperphagia, or slow mentation. Unilateral motor weakness was also noted in six cases. The tumor always involved the medial aspect of the left and right thalami, but was often more extensive. The pathology was determined to be grades I-IV astrocytoma, confirmed by stereotactic biopsy or autopsy in six. Mild to moderate hydrocephaly occurred in some cases and was considered to be a contributing factor to mental deterioration. No correlation was found between age and type of tumor.


CONCLUSIONS
Bilateral glioma of the dorsomedial and intralaminar nuclei of the thalamus can be a primary cause of dementia that has not been well-recognized in the past. CT and particularly MR should be considered for patients presenting with personality change or dementia, because of the possible presence of this unusual but devastating disease.
Partlow
G D
GD
Department of Radiology, Montreal Neurological Institute and Hospital, Quebec, Canada.
del Carpio-O'Donovan
R
R
Melanson
D
D
Peters
T M
TM
D000293:Adolescent; D000328:Adult; D002533:Cerebral Angiography; D002648:Child; D005260:Female; D005910:Glioma / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D010554:Personality Disorders / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D013786:Thalamic Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D014057:Tomography, X-Ray Computed