Identification of new urinary metabolites of trimeprazine in rats by gas chromatography-mass spectrometry.
The metabolites of trimeprazine were identified in urine of rats by gas chromatography-mass spectrometry. After the oral administration of trimeprazine, the urinary metabolites were extracted with diethyl ether before or after hydrolysis with beta-glucuronidase. The identified metabolites were N-demethyltrimeprazine,3-hydroxytrimeprazine,N-demethyl-3-++ +hydroxytrimeprazine and trimeprazine sulphoxide.
Kim
T J
TJ
Korea Institute of Science and Technology, Seoul, South Korea.
Park
J S
JS
Shin
H S
HS
D000818:Animals; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014291:Trimeprazine / Q000652:urine*
D014291:Trimeprazine