Thromboxane biosynthesis and metabolism in relation to cardiovascular risk factors.
Enhanced platelet biosynthesis of thromboxane A2 is associated with several cardiovascular risk factors, as a consequence of a direct effect on platelet biochemistry and/or some form of endothelial dysfunction. Moreover, episodic increases in thromboxane biosynthesis occur in acute coronary and cerebral ischemic syndromes. Thromboxane-dependent platelet activation represents an important mechanism that amplifies the consequences of acute vascular lesions as well as those of long-standing metabolic or hemodynamic disturbances, and results in increased risk of vascular occlusive events.
Patrono
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C
Department of Pharmacology, University of Chieti G. D'Annunzio School of Medicine, Italy.
Davì
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G
Ciabattoni
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G
D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D012307:Risk Factors; D013931:Thromboxanes / Q000096:biosynthesis* / Q000378:metabolism
D013931:Thromboxanes