title: Efficacy and safety of ivermectin applied topically to cattle under field conditions in Australia.
abstract: Fifteen controlled field trials were conducted to evaluate the efficacy against gastrointestinal nematodes and safety of ivermectin when applied topically to cattle in Australia. Three hundred and fifty-one cattle received ivermectin, and 88 were untreated controls. The trials were conducted in 3 States and included a variety of cattle breeds and environmental conditions. Faecal samples were collected before treatment and 11 to 14 days after treatment for nematode egg counts. Data from these trials show that under Australian conditions, ivermectin applied along the mid line of the back from the withers to the sacral region at a dose rate of 500 mcg/kg body weight, effectively controlled gastrointestinal nematode infections, and did not produce unacceptable adverse reactions in the animals.
authors.affiliation: Merck Sharp & Dohme Research Laboratories, Ingleburn, New South Wales.
authors.forename: J S
authors.initials: JS
authors.lastname: Eagleson
authors.forename: G R
authors.initials: GR
authors.lastname: Allerton
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001315:Australia; D001947:Breeding; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D005243:Feces / Q000469:parasitology; D005260:Female; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy*; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary
chemical_list: D007559:Ivermectin