In vitro antifungal activity of sertaconazole.
The antifungal activity of 7-chloro-3-[1-(2,4-dichlorophenyl)-2-(1H- imidazol-1-yl)ethoxy-methyl]benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) versus miconazole has been studied in vitro against yeast-like fungi, dermatophytes and other filamentous fungi. Candida albicans was very sensitive to sertaconazole both in serotype A and serotype B strains (MIC = 0.21 micrograms/ml). Sensitivity of Candida non albicans species (MIC = 0.17 microgram/ml), Torulopsis (MIC = 0.09 microgram/ml) and Trichosporon (MIC = 0.09 microgram/ml) was also remarkable. For dermatophytes, partial inhibitions were observed at concentrations of 0.04 and 0.09 microgram/ml, the 50% inhibition ranging between 0.36 and 12.56 micrograms/ml for most strains. Filamentous opportunistic fungi were less sensitive to azoles, although sertaconazole MICs were lower than those of miconazole. Sertaconazole also proved to possess a remarkable fungicidal activity on all strains of Candida albicans under study.
Drouhet
E
E
Unité de Mycologie, Institut Pasteur, Paris, France.
Dupont
B
B
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D003470:Culture Media; D005658:Fungi / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology*; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013876:Thiophenes / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole; D008825:Miconazole