The role of intracavernosal vasoactive agents to overcome impotence due to spinal cord injury.
Twenty-two spinal cord injured men (mean age 35.2 years) referred because of impotence were treated with intracavernosal vasoactive agents. Papaverine 2-20 mg, papaverine 40 mg plus phentolamine 0.5 mg or prostaglandin E1 (1-20 micrograms) were used. Nineteen responded and were taught to self administer the medication with varying degrees of assistance from their partners. Fourteen men participated in a postal survey; 12 (86%) continued to use the drugs every 1 to 4 weeks and reported satisfaction with the method. Partner responses were positive in half of the group and when not so it influenced the patients to abandon or reduce the frequency of treatment. Counselling was essential to allay anxiety. Clinical management was not compromised and side effects were minimal. Overall we found this treatment effective, safe and worthwhile.
Earle
C M
CM
Reproductive Medicine Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia.
Keogh
E J
EJ
Ker
J K
JK
Cherry
D J
DJ
Tulloch
A G
AG
Lord
D J
DJ
D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage / Q000627:therapeutic use; D010413:Penis; D010646:Phentolamine / Q000008:administration & dosage / Q000627:therapeutic use; D012646:Self Administration; D013119:Spinal Cord Injuries / Q000150:complications*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D014665:Vasodilator Agents; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine