title: [The Study Group of Quinapril in Arterial Hypertension. The Steering Committee].
abstract: The efficacy and safety of the treatment of arterial hypertension with the ACE-inhibitor quinapril, were evaluated in a multicentre study conducted in Italy. The study, lasting 14 weeks, after a preliminary wash-out period, allowed response-based titration of quinapril dose from 10 mg to 40 mg once a day, with provision to combine additional hydrochlorothiazide (12.5 to 25 mg), in case of persistently high diastolic pressure levels. The efficacy sample included 1267 patients: at therapy week 14, 78.6% of patients were treated with quinapril alone. Global response rate (intent-to-treat) was 83.3%, with a mean reduction of diastolic pressure of 15.8 mmHg (95% confidence interval from 15.5 to 16.2 mmHg). 91 patients reported 126 associated adverse events (7.0%); the most frequently reported event was cough (2.7%). First-dose hypotension was rarely reported (1.3%), even in elderly and diabetic patients.
authors.affiliation: Cattedra di Terapia Medica Sistematica, Università di Bologna.
authors.forename: E
authors.initials: E
authors.lastname: Ambrosioni
authors.forename: A
authors.initials: A
authors.lastname: Brusca
authors.forename: S
authors.initials: S
authors.lastname: Caponnetto
authors.forename: M
authors.initials: M
authors.lastname: Condorelli
authors.forename: L
authors.initials: L
authors.lastname: Corea
authors.forename: C
authors.initials: C
authors.lastname: Dal Palù
authors.forename: R
authors.initials: R
authors.lastname: Fogari
authors.forename: P
authors.initials: P
authors.lastname: Mameli
authors.forename: G
authors.initials: G
authors.lastname: Mancia
authors.forename: G G
authors.initials: GG
authors.lastname: Neri Serneri
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D004361:Drug Tolerance; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007546:Isoquinolines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007558:Italy; D000077583:Quinapril; D012074:Remission Induction; D016037:Single-Blind Method; D044005:Tetrahydroisoquinolines; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077583:Quinapril
vernacular_title: Gruppo di studio del quinapril nell'ipertensione arteriosa. Steering Committee.