Amiloride reduces intensity responses of human fungiform papillae.
Microdrop stimulation of human fungiform papillae was used to confirm that the drug amiloride reportedly reduces the taste response to NaCl and sucrose. Amiloride caused magnitude reductions of saltiness in most subjects and of sweetness for some but not all subjects. More of the subjects showed a reduction in response to NaCl than a reduction to sucrose and there were individual differences in the strength of the reduction of magnitude.
Tennissen
A M
AM
Department of Psychology, State University of New York, Albany 12222.
D000328:Adult; D000584:Amiloride / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007206:Individuality; D008297:Male; D012982:Sodium, Dietary; D013395:Sucrose; D013650:Taste Buds / Q000187:drug effects*; D013652:Taste Threshold / Q000187:drug effects*
D012982:Sodium, Dietary; D013395:Sucrose; D000584:Amiloride