title: In vivo 31P nuclear magnetic resonance spectroscopy of human temporal lobe epilepsy.
abstract: We performed localized 31P nuclear magnetic resonance (NMR) 1H-image-guided in vivo spectroscopy to study regional high-energy phosphate levels in the brains of normal controls and in patients with intractable unilateral temporal lobe epilepsy. We did not observe differences in intracellular pH between controls and patients. The phosphocreatine/inorganic phosphate ratio was reduced by 50% in the epileptogenic temporal lobe compared with controls (p less than 0.005) and by 35% when compared with the unaffected contralateral temporal lobe (p less than 0.05). We did not observe differences in the ratio of phosphomonoesters to phosphodiesters between controls and patients. These findings suggest that in vivo 31P NMR spectroscopy yields a distinctive interictal metabolic profile in patients with intractable unilateral temporal lobe epilepsy and may permit noninvasive lateralizing evidence of the seizure focus.
authors.affiliation: Department of Neurology, University of Alabama, Birmingham 35294.
authors.forename: R
authors.initials: R
authors.lastname: Kuzniecky
authors.forename: G A
authors.initials: GA
authors.lastname: Elgavish
authors.forename: H P
authors.initials: HP
authors.lastname: Hetherington
authors.forename: W T
authors.initials: WT
authors.lastname: Evanochko
authors.forename: G M
authors.initials: GM
authors.lastname: Pohost
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010758:Phosphorus; D012016:Reference Values; D013702:Temporal Lobe / Q000473:pathology
chemical_list: D010758:Phosphorus