The pharmacokinetics of fluconazole during haemodialysis in uraemic patients.
We have studied the pharmacokinetics of fluconazole in five patients on long-term haemodialysis. The single-pass extraction rate of the dialyzer was 59 (3.5)% (n = 4), and the serum concentration was reduced by haemodialysis for 3 or 4 h by 26 (3.2)% (n = 5) and 39 (2.2)% (n = 9) respectively. The estimated amount extracted by a dialysis of 4 h was 33 (3.2)% (n = 4) of the dose. During repeated administration the serum fluconazole concentration increased, reaching a plateau at about 4 times the peak concentration after the first dose. After discontinuing administration the serum fluconazole concentration fell by 25% in every 3 h dialysis session. We conclude that fluconazole should be given in the usual dose of 100 or 200 mg at the end of every haemodialysis session.
Oono
S
S
Department of Medicine, Jichi Medical School, Tochigi, Japan.
Tabei
K
K
Tetsuka
T
T
Asano
Y
Y
D000368:Aged; D015725:Fluconazole / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism*
D015725:Fluconazole