New artificial connective matrix-like structure: thrombogenicity and use as endothelial cell culture support.
The recently described artificial connective matrix made of elastin solubilized peptides, type I+III collagens and connective proteins is shown to have structural and biological properties very close to the natural arterial subendothelium: the capacity to promote endothelial cell cultures maintaining their phenotype expression and its non-thrombogenicity. This new bioactive composite material could be used to replace arteries.
Bordenave
L
L
INSERM-U. 306, Université de Bordeaux II, France.
Lefebvre
F
F
Bareille
R
R
Rouais
F
F
Baquey
C
C
Rabaud
M
M
D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D002448:Cell Adhesion; D002455:Cell Division; D002478:Cells, Cultured; D003094:Collagen; D003238:Connective Tissue / Q000737:chemistry; D004730:Endothelium, Vascular / Q000166:cytology*; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010455:Peptides; D010973:Platelet Adhesiveness; D011506:Proteins; D013927:Thrombosis / Q000517:prevention & control
D001672:Biocompatible Materials; D010455:Peptides; D011506:Proteins; D003094:Collagen