Rabies virus neuritic paralysis: immunopathogenesis of nonfatal paralytic rabies.
Two pathogenetically distinct disease manifestations are distinguished in a murine model of primary rabies virus infection with the Evelyn-Rokitnicky-Abelseth strain, rabies virus neuritic paralysis (RVNP) and fatal encephalopathogenic rabies. RVNP develops with high incidence in immunocompetent mice after intraplantar infection as a flaccid paralysis restricted to the infected limb. The histopathologic correlate of this monoplegia is a degeneration of the myelinated motor neurons of the peripheral nerve involved. While, in this model, fatal encephalopathogenic rabies develops only after depletion of the CD4 subset of T lymphocytes and without contribution of the CD8 subset, RVNP is identified as an immunopathological process in which both the CD4 and CD8 subsets of T lymphocytes are critically implicated.
Weiland
F
F
Federal Research Centre for Virus Diseases of Animals, Tübingen, Germany.
Cox
J H
JH
Meyer
S
S
Dahme
E
E
Reddehase
M J
MJ
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D007121:Immunocompetence; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009046:Motor Neurons / Q000473:pathology; D009186:Myelin Sheath / Q000648:ultrastructure; D009474:Neurons / Q000382:microbiology / Q000473:pathology; D010243:Paralysis / Q000209:etiology / Q000276:immunology* / Q000473:pathology*; D011818:Rabies / Q000276:immunology* / Q000473:pathology*; D011820:Rabies virus / Q000472:pathogenicity*; D012584:Sciatic Nerve / Q000473:pathology / Q000648:ultrastructure; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015704:CD4 Antigens; D016827:CD8 Antigens