Decreases in catecholamine concentrations of cisternal cerebrospinal fluid and plasma in rats caused by pentobarbital anesthesia.
Pentobarbital anesthesia led to a decrease of noradrenaline concentrations of both cisternal cerebrospinal fluid and plasma and adrenaline concentration of plasma with a concomitant decrease in blood pressure in rats. These data suggest that pentobarbital suppresses both central and peripheral noradrenergic nervous activity.
Takemoto
Y
Y
Department of Physiology, Hiroshima University School of Medicine, Japan.
D000758:Anesthesia / Q000009:adverse effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004837:Epinephrine / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D009638:Norepinephrine / Q000097:blood / Q000134:cerebrospinal fluid*; D010424:Pentobarbital / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D010424:Pentobarbital; D009638:Norepinephrine; D004837:Epinephrine