Immunotherapy with stimulated autologous lymphocytes in a case of a juvenile anaplastic glioma.
The effect of immunotherapy with stimulated autologous lymphocytes (SAL) in malignant gliomas is documented and discussed in a bioptical and autoptical case study. A five-year-old child with a recurrently operated and radiated right hemispheric anaplastic astrocytoma died six weeks after immunotherapy with mitogen-activated killer cells and recombinant Interleukin-2. The autopsy revealed a large butterfly glioma with partially necrotic gelatinous tissue at the site of the SAL reservoir. The tumor cell density on the right was less than on the left hemisphere, and T-lymphocyte content was higher on the right hemisphere. These results demonstrate a local effect of SAL therapy in vivo, although the tumor progression as a whole could not be stopped. They also demonstrate the need of a detailed neuropathological examination in all cases of immunotherapy of malignant gliomas.
Thomas
C
C
Department of Neuropathology, Heinrich-Heine-university, Düsseldorf, Germany.
Schober
R
R
Lenard
H G
HG
Lumenta
C B
CB
Jacques
D B
DB
Wechsler
W
W
D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002540:Cerebral Cortex / Q000473:pathology; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007376:Interleukin-2 / Q000008:administration & dosage*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology / Q000637:transplantation*; D008213:Lymphocyte Activation / Q000276:immunology; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000473:pathology / Q000628:therapy
D007376:Interleukin-2