Pharmacokinetics of diphemanil methylsulphate in healthy subjects.
The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.
Vidal
A M
AM
Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
Rey
E
E
Pons
G
G
Pello
J Y
JY
d'Athis
P
P
Olive
G
G
D000284:Administration, Oral; D000328:Adult; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics*
D010880:Piperidines; C028209:diphemanil methylsulfate