Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity.
Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high-asthma strain (IMM/S 209) and one low-asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains - one high-asthma strain (IMM/S 740) and one low-asthma strain (IMM/R 201-16) - maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)3 the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete adjuvant (FCA).
Winthereik
M P
MP
Institute of Medical Microbiology, University of Copenhagen, Denmark.
Lundberg
L
L
Spärck
J V
JV
Katzenstein
T
T
Sompolinsky
D
D
D000375:Aging; D000536:Aluminum Hydroxide; D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D004198:Disease Susceptibility; D004802:Eosinophilia / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006168:Guinea Pigs / Q000235:genetics*; D007958:Leukocyte Count; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D013045:Species Specificity
D012965:Sodium Chloride; D000536:Aluminum Hydroxide; D010047:Ovalbumin