title: [Noninvasive function tests in the evaluation of vascular reactivity in pregnancy and pregnancy-induced hypertension].
abstract: At present, there is an increasing discussion regarding the change of the prostacyclin/thromboxane ratio as an aetiological factor of pregnancy-induced hypertension (PIH). By means of videophotometric capillaroscopy in the capillaries of the nailfold, it is possible to visualise the resulting changes in the microcirculation. This method employs a special illumination microscope (magnification of the optical system x 560). Red blood cell velocity is measured under test conditions and microcirculatorical reaction capacity on ischaemic stress. Studies were conducted on healthy non-pregnant women and on healthy pregnant women as well as on patients suffering from pregnancy-induced hypertension. A markedly reduced velocity of red blood cells in patients with pregnancy-induced hypertension was seen as a sign of vasoconstriction, namely, 0.53 mm/sec. versus 0.74 mm/sec. Furthermore, these patients have a higher reactivity to ischaemic stress, probably also as a result of the already existing vasoconstriction; however, the duration of the hyperaemic phases is reduced in pregnancy-induced hypertension. By this method, an insight can be gained into microcirculation in pregnancy and in pregnancy-induced hypertension. In addition, as preliminary studies have already shown, the influence exercised by different medications on microcirculation can be assessed.
authors.affiliation: Universitätsfrauenklinik und Poliklinik mit Hebammenlehranstalt Homburg/Saar.
authors.forename: P
authors.initials: P
authors.lastname: Ohlmann
authors.forename: F
authors.initials: F
authors.lastname: Jung
authors.forename: P
authors.initials: P
authors.lastname: Rosenbaum
authors.forename: B
authors.initials: B
authors.lastname: Hummel
authors.forename: J
authors.initials: J
authors.lastname: Schäfer
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D004461:Eclampsia / Q000503:physiopathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology; D008833:Microcirculation / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000503:physiopathology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D014655:Vascular Resistance / Q000502:physiology*
vernacular_title: Nichtinvasiver Funktionstest zur Uberprüfung der Gefässreagibilität in der Schwangerschaft und bei schwangerschaftsinduzierter Hypertension (SIH).