title: [Diclofenac-dexamethasone combination in treatment of postoperative inflammation: prospective double-blind study].
abstract: In a prospective randomized double masked study including 40 patients we evaluated the anti-inflammatory effect of a combination of dexamethasone acetate 0.1% + diclofenac 0.1% drops compared to dexamethasone acetate 0.1% + placebo drops, after ECCE + posterior chamber lens implantation. Anterior chamber (AC) flare and cells were measured with the laser flare-cell meter Kowa FC-1000. The group receiving the dexamethasone-diclofenac combination showed a more rapid decrease of AC flare which was significant at days D3 (P less than 0.003) and D12 (p less than 0.028). The reduction of AC cells was comparable in both groups, showing however a strong tendency toward a lower cell count in the group receiving diclofenac at days D12 and D30 (p less than 0.08). Tolerance of diclofenac was good and comparable to the placebo.
authors.affiliation: Hôpital Jules Gonin, Service d'ophtalmologie, Université de Lausanne.
authors.forename: P
authors.initials: P
authors.lastname: Othenin-Girard
authors.forename: X
authors.initials: X
authors.lastname: Borruat
authors.forename: E
authors.initials: E
authors.lastname: Bovey
authors.forename: N
authors.initials: N
authors.lastname: Pittet
authors.forename: C P
authors.initials: CP
authors.lastname: Herbort
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000187:drug effects*; D003907:Dexamethasone / Q000008:administration & dosage*; D004008:Diclofenac / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D004008:Diclofenac; D003907:Dexamethasone
vernacular_title: Association diclofenac-dexamethasone dans le traitement de l'inflammation postopératoire: étude prospective en double-insu.