Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.
A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.
Tamura
K
K
Department of Biology, Tokyo Metropolitan University.
D000818:Animals; D001482:Base Composition; D003198:Computer Simulation; D003596:Cytosine; D004247:DNA / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics; D004330:Drosophila / Q000235:genetics*; D005821:Genetic Techniques; D006151:Guanosine; D008433:Mathematics; D008957:Models, Genetic
D004272:DNA, Mitochondrial; D006151:Guanosine; D003596:Cytosine; D004247:DNA