High levels of anti-Campylobacter-flagellin IgA antibodies in breast milk.
Several studies have shown the beneficial role of immunity against enteric Campylobacter sp. Circulating antibodies against flagellin and possibly maternal antibodies seem to protect against intestinal colonization by Campylobacter. Milk from women in Central Africa (n = 120) and in France (n = 31) were investigated for the presence of anti-flagellin antibodies. Results showed that most French and all African milk possessed anti-flagellin IgA but not IgG. The titres of anti-flagellin IgA were elevated in colostrum and decreased in later milk. Specific activities were constant during lactation, suggesting constant antigenic stimulation. The fact that IgA but not IgG are elicited against flagellin could be due to an infection limited to the mucosal surface.
Renom
G
G
Institut Pasteur, Bangui.
Kirimat
M
M
Georges
A J
AJ
Philippe
J C
JC
Martin
P M
PM
D000328:Adult; D002167:Campylobacter / Q000276:immunology*; D002169:Campylobacter Infections / Q000276:immunology / Q000517:prevention & control; D005260:Female; D005408:Flagellin / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D066298:In Vitro Techniques; D007231:Infant, Newborn; D008895:Milk, Human / Q000276:immunology*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005408:Flagellin