title: Clozapine decreases enkephalin mRNA in rat striatum.
abstract: Typical antipsychotic drugs (i.e. haloperidol) induce extrapyramidal movement disorders while 'atypical' antipsychotics (i.e. clozapine) do not. In situ hybridization histochemistry followed by film autoradiography showed that clozapine treatment (20 mg/kg i.p. daily for 28 days) decreased the level of labelling for preproenkephalin mRNA in the striatum of the rat while haloperidol treatment (1 mg/kg i.p. daily for 28 days) resulted in no change compared with controls. The results suggest that these typical and atypical antipsychotic drugs exert differential effects on the enkephalin-containing striatal projection to the globus pallidus, a pathway critical for the expression of extrapyramidal movement disorders.
authors.affiliation: Department of Pharmacology, University of Pennsylvania, Philadelphia 19104.
authors.forename: M
authors.initials: M
authors.lastname: Mercugliano
authors.forename: M F
authors.initials: MF
authors.lastname: Chesselet
mesh_terms: D000818:Animals; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000503:physiopathology; D003024:Clozapine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D003864:Depression, Chemical; D004525:Efferent Pathways / Q000502:physiology; D004745:Enkephalins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D005917:Globus Pallidus / Q000187:drug effects / Q000502:physiology; D006220:Haloperidol / Q000009:adverse effects / Q000494:pharmacology; D008297:Male; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004745:Enkephalins; D011498:Protein Precursors; C033660:preproenkephalin; D003024:Clozapine; D006220:Haloperidol