Rate and types of fractures in corticosteroid-treated multiple sclerosis patients.
In a retrospective study of 103 corticosteroid-treated MS patients, the average rate of fracture events was 3.2% of the patients per year over 7.1 (+/- 5.7 SD) years at risk. Fractures of the ribs, pelvis, hip, or vertebrae occurred in 11 patients and became most common 5 years after starting steroids. Relatively high or low cumulative doses of steroids did not correlate predictably with the occurrence of fractures.
Troiano
R A
RA
Department of Neurosciences, UMDNJ-New Jersey Medical School, Newark 07103.
Jotkowitz
A
A
Cook
S D
SD
Bansil
S
S
Zito
G
G
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000367:Age Factors; D004305:Dose-Response Relationship, Drug; D005260:Female; D050723:Fractures, Bone / Q000139:chemically induced / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors
D000305:Adrenal Cortex Hormones