Constitutional balanced translocations in patients with solid tumors.
In a sample of 329 patients with a solid tumor (colon and breast adenocarcinoma, cervical carcinoma, and meningioma), four balanced constitutional translocations were observed. Two were t(13q14q), and two were reciprocal translocations. Comparison with surveys of newborns showed a significant excess of translocations in our sample.
Richard
F
F
CNRS URA 620, Institut Curie, Section de Biologie, Paris, France.
Muleris
M
M
Couturier
J
J
Gerbault-Seureau
M
M
Lombard
M
M
Dutrillaux
B
B
D000230:Adenocarcinoma / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics; D002871:Chromosome Banding; D002873:Chromosome Fragility; D002879:Chromosomes, Human, Pair 10; D002882:Chromosomes, Human, Pair 13; D002883:Chromosomes, Human, Pair 14; D002884:Chromosomes, Human, Pair 15; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D015179:Colorectal Neoplasms / Q000235:genetics; D005260:Female; D006801:Humans; D008579:Meningioma / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic; D002583:Uterine Cervical Neoplasms / Q000235:genetics