title: Treatment of proximal aortic hypertension after thoracic aortic cross-clamping in dogs. Phlebotomy versus sodium nitroprusside/isoflurane.
abstract: Thoracic aortic cross-clamping causes proximal aortic hypertension. Theoretically, the method used to treat hypertension can influence spinal cord perfusion pressure and neurologic outcome. Phlebotomy was compared to sodium nitroprusside/isoflurane in terms of ability to treat increased proximal mean aortic pressure (MAPp) after thoracic aortic cross-clamping in dogs. Dogs were assigned randomly to one of three groups depending on the method used to treat hypertension after cross clamping: 1) phlebotomy (n = 10); 2) sodium nitroprusside/isoflurane (n = 11); and 3) control (no treatment) (n = 8). In each dog, anesthesia was maintained with isoflurane in oxygen, 1.4% end-tidal. The thoracic aorta was occluded 2.5 cm distal to the left subclavian artery for 50 min and then was released. Hemodynamics, cerebrospinal fluid pressure (CSFP), and regional blood flows by the radioactive microsphere technique, were measured at 1) baseline; 2) 2 min after aortic cross-clamping; 3) after treatment of proximal aortic hypertension; 4) 5 min after aortic unclamping; and 5) 30 min after resuscitation. At 24 h, a neurologic assessment was performed. Thoracic aortic cross-clamping increased MAPp, decreased distal MAP (MAPd), and reduced lumbar spinal cord perfusion pressure (SCPPl), [SCPPl = MAPd - CSFP], in all three groups. Control of increased MAPp necessitated removal of 36 +/- 9 ml/kg of blood in the phlebotomy group. In the sodium nitroprusside/isoflurane group, sodium nitroprusside (16 micrograms.kg-1.min-1) was infused and end-tidal isoflurane concentration increased to 2.5 +/- 0.7%, restoring MAPp to baseline level.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
authors.forename: F J
authors.initials: FJ
authors.lastname: Clark
authors.forename: W A
authors.initials: WA
authors.lastname: Mutch
authors.forename: I R
authors.initials: IR
authors.lastname: Sutton
authors.forename: J M
authors.initials: JM
authors.lastname: Teskey
authors.forename: K
authors.initials: K
authors.lastname: McCutcheon
authors.forename: D B
authors.initials: DB
authors.lastname: Thiessen
authors.forename: M
authors.initials: M
authors.lastname: Rosenbloom
authors.forename: I R
authors.initials: IR
authors.lastname: Thomson
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic; D001018:Aortic Diseases / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D001815:Bloodletting; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D003250:Constriction; D004285:Dogs; D006439:Hemodynamics / Q000502:physiology; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D007530:Isoflurane / Q000008:administration & dosage / Q000627:therapeutic use*; D009599:Nitroprusside / Q000008:administration & dosage / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D009599:Nitroprusside; D007530:Isoflurane