[Serum and urinary inorganic fluoride levels after prolonged inhalation of sevoflurane in man].
The serum and urinary concentrations of inorganic fluoride were measured before and after sevoflurane anesthesia in ten patients without renal disease, who underwent surgeries lasting for 13.4 +/- 0.9 hours. The mean concentration of serum inorganic fluoride reached a maximal value of 42.5 +/- SE mumol.liter-1 at the end of anesthesia. However, the serum inorganic fluoride concentration increased over 50 mumol.liter-1 which is called "nephrotoxic threshold" in five of ten patients. A positive correlation was found between serum inorganic fluoride concentration and anesthetic dose. The largest urinary excretion of inorganic fluoride was 1804 +/- SE mumol.day-1 in the first postoperative day and the excretion decreased rapidly thereafter. We conclude that while nephrotoxicity was not demonstrated from biochemical data in this study, prolonged inhalation of sevoflurane (13.4 +/- 0.9 hours) increases serum inorganic fluoride concentration during and after the inhalation which may influence renal function.
Kobayashi
Y
Y
Department of Anesthesiology, Keio University School of Medicine, Tokyo.
D000769:Anesthesia, Inhalation; D004987:Ethers; D005260:Female; D005459:Fluorides / Q000097:blood* / Q000652:urine*; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D008875:Middle Aged; D000077149:Sevoflurane; D013514:Surgical Procedures, Operative; D013997:Time Factors
D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D005459:Fluorides