title: Changes in the CA 19-9 antigen and Lewis blood group with pulmonary disease severity in cystic fibrosis.
abstract: The altered carbohydrate structure of sputum from patients with cystic fibrosis (CF) has been thought to be due to the inflammatory airway response. Carcinoembryonic antigen (CEA) and CA 19-9 detect sialosylated carbohydrates in mucus. The epitope of CA 19-9 is part of the Lewis A (Le(a)) blood group antigen. Serum concentrations of CEA and CA 19-9 were determined by radioimmunoassay in 41 CF patients, aged 6-34 years; 16 were asymptomatic Outpatients, and 25 had been admitted for pulmonary exacerbations. There was no difference in CEA between groups. The CA 19-9 serum concentration was elevated in 90% of patients who had at least one of the two Lewis antigens. The CA 19-9 concentration of Inpatients with exacerbations was 2.7 times that of stable Outpatients (263 +/- 44 versus 99 +/- 13 U/mL; P less than 0.02). CA 19-9 correlated significantly with age (r = 0.35, P less than 0.05), Brasfield score (r = 0.39, P less than 0.015), pulmonary function tests, cough severity (r = 0.50, P less than 0.001) and NIH clinical score (r = 0.57, P less than 0.001). CA 19-9 concentration of Inpatients decreased by 44% from admission to discharge (302 +/- 45 to 169 +/- 39, P less than 0.02). Fourteen of 25 (56%) of the Inpatients were Le(a) positive versus only 3/15 (20%) of Outpatients who had milder lung disease (P less than 0.002). Of the Inpatients, 25% with more advanced lung disease were Le(a+b+), a rare blood group in the normal population, and one not observed in the Outpatients with milder disease.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: St. Louis University School of Medicine, MO.
authors.forename: R E
authors.initials: RE
authors.lastname: Kane
authors.forename: J
authors.initials: J
authors.lastname: Penny
authors.forename: K
authors.initials: K
authors.lastname: Walker
authors.forename: B K
authors.initials: BK
authors.lastname: Rubin
authors.forename: J
authors.initials: J
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis* / Q000276:immunology; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007983:Lewis Blood Group Antigens / Q000276:immunology*; D008168:Lung / Q000503:physiopathology*; D011863:Radioimmunoassay; D012129:Respiratory Function Tests; D012720:Severity of Illness Index
chemical_list: D000911:Antibodies, Monoclonal; D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D007983:Lewis Blood Group Antigens