title: Tube-perilymph fistula. An experimental study.
abstract: Before exploratory tympanotomy, it is difficult to diagnose an idiopathic perilymph fistula (PLF) because of its variable presentations. An animal model tube-PLF on guinea pigs was established to evaluate the change of the sensitivity of the cochlea function and the value of the postural audiometry in PLF. A fine polyethylene tube (O.D. 0.6mm) was inserted into the scala tympani of the basal turn through the incised round window membrane in 10 experimental guinea pigs, and another 5 as controls. The hearing threshold (HT), action potential (AP) latency for stimulus of 105 dB SPL, difference of HT and AP latency from the test ear down to up were measured by electrocochleography (ECoG) immediately after operation and one week later. The HT, AP latency and postural audiometry showed no significant changes immediately but a significant difference one week later in HT (P less than 0.01) and postural audiometry, the AP latency also presented a significant delay (P less than 0.01). The results showed that the tube-PLF model may be a valuable method for studying chronic PLF.
authors.affiliation: Department of Otolaryngology, 2nd Affiliated Hospital, Hunan Medical University, Changsha.
authors.forename: Y D
authors.initials: YD
authors.lastname: Lu
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: B F
authors.initials: BF
authors.lastname: McCabe
mesh_terms: D000200:Action Potentials; D000818:Animals; D001299:Audiometry; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold; D004195:Disease Models, Animal; D005402:Fistula / Q000503:physiopathology; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000503:physiopathology; D010498:Perilymph; D012405:Round Window, Ear; D012533:Scala Tympani