title: Lipoprotein-containing apolipoprotein A-I: sex-related quantitative and qualitative changes in this lipoprotein subspecies after ingestion of fat.
abstract: We investigated the postprandial changes of two species of lipoproteins containing apolipoprotein (apo)A-I: lipoprotein containing apo A-I but no apo A-II (LpA-I), and lipoprotein containing apo A-I and apo A-II (LpA-I/A-II). These lipoproteins were isolated from 10 men and 11 women at 0, 4, and 6 h after they had eaten butter. In LpA-I, the concentrations of all lipids except triglyceride were increased at 4 and 6 h in the women. In the men all lipids were increased only at 4 h. The increase of apo A-I concentration was found at 6 h only in the women. In LpA-I/A-II, the concentrations of all lipids were increased at 4 h and only phospholipid (PL) was increased at 6 h in the women. In the men, free cholesterol and PL were increased at 4 and 6 h. The increases of apo A-I and apo A-II concentrations were found at 4 and 6 h only in the men. These results suggest that the postprandial changes are sex-related and may relate to the different incidence of atherosclerotic cardiovascular disorders.
authors.affiliation: Department of Pediatrics, Kumamoto University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: R
authors.initials: R
authors.lastname: Nakamura
authors.forename: I
authors.initials: I
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000032:analysis*; D016633:Apolipoprotein A-II / Q000032:analysis; D001053:Apolipoproteins / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000378:metabolism*; D004435:Eating / Q000502:physiology; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D008055:Lipids / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood; D008074:Lipoproteins / Q000737:chemistry*; D008297:Male; D012737:Sex Factors
chemical_list: D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001053:Apolipoproteins; D004041:Dietary Fats; D008055:Lipids; D008074:Lipoproteins; D008049:Lipase; D008071:Lipoprotein Lipase