[Is angiotensin II a growth factor?].
Angiotensin II is an octapeptide resulting from the enzymatic cascade of the renin-angiotensin system and involved in vasoconstriction and aldosterone secretion. The extensive use of converting enzyme inhibitors recently suggested that angiotensin II may have a specific action on growth of its target tissues. Cellular models confirm that angiotensin II is able to produce in vitro a cellular hypertrophy of many cell types. Nevertheless a controversy was developed on the real possibility for angiotensin II to act on cell division. Some cells, such as adrenocortical cells, present a clear induction of their division by angiotensin II, but contradictory results were obtained on vascular smooth muscle cells. The mechanism by which angiotensin II induces hypertrophy of its target tissues, is largely unknown but may involve a direct action on proto-oncogene synthesis, or an indirect action on growth factor secretion. The nature of the angiotensin II receptor involved in these mechanisms has to be identified.
Clauser
E
E
INSERM U36, Collège de France, Paris.
Bihoreau
C
C
Monnot
C
C
Teutsch
B
B
Conchon
S
S
Davies
E
E
Corvol
P
P
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002455:Cell Division; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D000090063:Proto-Oncogene Mas; D011945:Receptors, Angiotensin / Q000502:physiology; D012084:Renin-Angiotensin System
D006133:Growth Substances; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011945:Receptors, Angiotensin; D000804:Angiotensin II
L'angiotensine II est-elle un facteur de croissance?