Lack of pharmacokinetic interaction between intravenous 2',3'-dideoxyinosine and 3'-azido-3'-deoxythymidine in rats.
We investigated the pharmacokinetic interaction between 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI), given to rats by intravenous injection. For both compounds, the clearances, terminal half-lives, and fractions of the dose excreted unchanged in urine were not altered by the other drug (P greater than 0.05), indicating no pharmacokinetic interaction between the two drugs.
Wientjes
M G
MG
Department of Surgery, Comprehensive Cancer Center, Columbus, Ohio.
Au
J L
JL
D000818:Animals; D016049:Didanosine / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006207:Half-Life; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D051381:Rats; D015215:Zidovudine / Q000097:blood / Q000493:pharmacokinetics*
D015215:Zidovudine; D016049:Didanosine