Erythropoietin levels in patients depositing autologous blood in short intervals.
Plasma immunoreactive erythropoietin (EPO) concentrations were studied in ten patients (7 men, 3 women) predonating autologous blood for hip arthroplasty. Donations were scheduled on day 1, 3, 7, 14 (and 21 if four units could not be donated previously). A predonation hemoglobin concentration of 11 g/dl was required. The donations led to a decline of the hemoglobin concentration from 14.1 +/- 1.0 g/dl (X +/- SD) prior to donation to 11.0 +/- 0.9 g/dl on day 15. EPO concentration prior to donation was 17.6 +/- 2.6 mU/ml. Each phlebotomy was followed by a rise in EPO levels that reached a peak concentration within 1 day. The highest concentration (35.8 +/- 15.0 mU/ml) was measured on day 16. The peak concentration was followed by a plateau at lower, although still elevated levels after the first and second donation, and by a slow, continuous decline after the third and fourth donation. This particular time course is similar to that during weekly donations [15]. The time integral of the EPO concentration during the first 3 weeks, however, was greater in the present study. This increased availability of EPO early during donation may lead to a more efficient stimulation of erythropoiesis.
Lorentz
A
A
Institut für Anästhesiologie und operative Intensivmedizin am Klinikum Mannheim, medizinischen Fakultät, Universität Heidelberg, Mannheim, Federal Republic of Germany.
Eckardt
K U
KU
Osswald
P M
PM
Duchow
J R
JR
D001772:Blood Cell Count; D001782:Blood Donors; D001804:Blood Transfusion, Autologous; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood*; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D009994:Osmolar Concentration; D013997:Time Factors
D006454:Hemoglobins; D004921:Erythropoietin; D005293:Ferritins