Postoperative elevations of serum interleukin 6 and group II phospholipase A2: group II phospholipase A2 in serum is an acute phase reactant.
Elevations of serum immunoreactive interleukin 6 (IL-6) and Group II phospholipase A2 (M-PLA2) were observed without exception after elective surgeries for various sites. Serum IL-6 rose steeply after surgery, and reached the maximum level on the 1st postoperative day. Serum M-PLA2 increased from the 1st postoperative day and reached the maximum level on the 2nd postoperative day in 10 patients (76.9%), on the first day after surgery in 2 patients and on the 3rd day in one patient. The peak serum M-PLA2 after surgery was significantly correlated with the peak IL-6 and blood loss volume during surgery. These results suggested that serum M-PLA2 is an acute phase reactant.
Ogawa
M
M
Department of Surgery II, Kumamoto University Medical School, Japan.
Arakawa
H
H
Yamashita
S
S
Sakamoto
K
K
Ikei
S
S
D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D002769:Cholelithiasis / Q000097:blood / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000601:surgery; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011184:Postoperative Period; D013514:Surgical Procedures, Operative
D015850:Interleukin-6; D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2