Healing of open skin surfaces with collagen foils.
Applications of Condress (patented sheets of pure bovine collagen) on open skin surfaces (30 cases of "ulcus cruris", 5 cases of decubitus, and malum perforans; 10 cases of full-thickness burns) were examined in a controlled trial. Quantification of regeneration speed, macrophotographic survey of granulation tissue and epithelial border, thermographic and chromometric evaluation of the skin microcirculation, and histological observation of regenerating tissues, were the parameters used. The following results were obtained: marked reduction of healing time, different aspects of the granulation-tissue responses, different times of topical collagenolysis, increased vascular perfusion, histological activation of angiogenesis, fibrogenesis, histiomacrophage function and superficial absorption. The employment of Condress in burn areas seems to be highly promising.
Mian
E
E
Dermatological Clinic, University of Milan, Italy.
Martini
P
P
Beconcini
D
D
Mian
M
M
D001684:Biological Dressings; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D002921:Cicatrix / Q000188:drug therapy; D003094:Collagen / Q000008:administration & dosage*; D006801:Humans; D008833:Microcirculation / Q000187:drug effects; D012038:Regeneration / Q000187:drug effects; D012883:Skin Ulcer / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D003094:Collagen