[Expression of cytochrome P-450 genes].
Cytochromes P-450 are important in the oxidative metabolism of many endogenous substrates, as well as innumerable drugs, chemical carcinogens, and environmental pollutants. Biochemical analyses of cytochrome P-450 have revealed multiple isoenzymes. Information for synthesis of these isoenzymes is contained in different genes. Based on the degree of relatedness in DNA sequence, the genes for cytochrome P-450 have been classified into different families, constituting cytochrome P-450 multigene superfamily. Particular chemicals induce expression of one or more genes belonging to definite cytochrome P-450 family. Expression of these genes may have served as a mechanism by which the cell respond to specific chemical signals (xenobiotic or hormonal).
Lutz
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Instytut Medycyny Pracy, Lodzi.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D010908:Pituitary Hormones, Anterior / Q000378:metabolism; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects / Q000235:genetics*
D007527:Isoenzymes; D010908:Pituitary Hormones, Anterior; D011285:Pregnenolone Carbonitrile; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Ekspresja genów cytochromów P-450.