Daytime sleep tendency before and after discontinuation of antiepileptic drugs in preadolescent children with epilepsy.
In 9 preadolescent children treated for epilepsy who had been free from seizures long enough for treatment to be discontinued, daytime vigilance was studied before and after discontinuation of antiepileptic drugs (AEDs). Comparisons were made with healthy controls. Multiple sleep latency test (MSLT), EEG, and a questionnaire were used. As part of the analysis of the MSLT, a new measure, the daily average sleep tendency (DAST), was constructed to overcome the problems with data censoring of the classic MSLT analysis. The patients had significantly (p less than 0.001) higher daytime sleep tendency, even after drug discontinuation, than controls, a result that could neither be attributed to AED treatment nor to recent epileptic seizures or complicated epilepsy.
Palm
L
L
Department of Pediatrics, University of Lund, Sweden.
Anderson
H
H
Elmqvist
D
D
Blennow
G
G
D000927:Anticonvulsants / Q000008:administration & dosage*; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology
D000927:Anticonvulsants