Testing otolith function.
Otolithic signals contribute to; (1) perception of orientation and linear motion, (2) generate compensatory eye movements in response to linear acceleration of the head and (3) participate in the co-ordination of movement and balance. Tests of these functions shown to be useful in identifying clinical disorders have been reviewed: (1) Evaluation of orientation to gravity, as estimated by adjustment of the visual vertical, indicates deranged otolith function at a peripheral or central level and the sensitivity of this test can be enhanced by performing estimates during centrifugation on a motorised turntable. Estimation of thresholds of self motion on a parallel swing identifies global reduction or unilateral loss of peripheral function, with central disorders awaiting study. (2) Otolith ocular reflexes to linear head translation can be used to demonstrate overall integrity of peripheral function and reveal central abnormalities. Counter-rolling responses to head roll-tilt and measurements of cyclodeviation of the eyes demonstrate functional asymmetries, with some lateralising value, particularly in central lesions. Global function and asymmetries may also be evaluated by 'head eccentric' rotational testing, which adds a tangential linear acceleration to the angular stimulus. The linear acceleration enhances the canal response by adding an otolith component. (3) Latency and amplitude of surface electro-myography (EMG) responses in the limbs to sudden falls, which can be recorded with the subject suspended on a hinged bed, indicate gross peripheral abnormality of function and can lateralize disorders of CNS motor pathways. It is concluded that some tests of otolith function can be of use in indicating global loss of peripheral otolith function, others are capable of lateralizing a marked loss of function and all have the potential to give information about central disorders. They all have to be interpreted within the clinical context and, unfortunately, none have yet been shown to be sensitive to partial, particularly unilateral, dysfunction.
Gresty
M A
MA
Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, London, UK.
Bronstein
A M
AM
D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000175:diagnosis / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology; D007758:Ear, Inner / Q000503:physiopathology; D005128:Eye Diseases / Q000175:diagnosis / Q000503:physiopathology; D005133:Eye Movements / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009039:Motion Perception / Q000502:physiology; D009949:Orientation / Q000502:physiology; D010037:Otolithic Membrane / Q000502:physiology* / Q000503:physiopathology; D011187:Posture; D015837:Vestibular Diseases / Q000175:diagnosis* / Q000503:physiopathology; D014724:Vestibular Function Tests / Q000379:methods*; D014722:Vestibule, Labyrinth / Q000503:physiopathology