title: Immunotherapy with stimulated autologous lymphocytes in a case of a juvenile anaplastic glioma.
abstract: The effect of immunotherapy with stimulated autologous lymphocytes (SAL) in malignant gliomas is documented and discussed in a bioptical and autoptical case study. A five-year-old child with a recurrently operated and radiated right hemispheric anaplastic astrocytoma died six weeks after immunotherapy with mitogen-activated killer cells and recombinant Interleukin-2. The autopsy revealed a large butterfly glioma with partially necrotic gelatinous tissue at the site of the SAL reservoir. The tumor cell density on the right was less than on the left hemisphere, and T-lymphocyte content was higher on the right hemisphere. These results demonstrate a local effect of SAL therapy in vivo, although the tumor progression as a whole could not be stopped. They also demonstrate the need of a detailed neuropathological examination in all cases of immunotherapy of malignant gliomas.
authors.affiliation: Department of Neuropathology, Heinrich-Heine-university, Düsseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Schober
authors.forename: H G
authors.initials: HG
authors.lastname: Lenard
authors.forename: C B
authors.initials: CB
authors.lastname: Lumenta
authors.forename: D B
authors.initials: DB
authors.lastname: Jacques
authors.forename: W
authors.initials: W
authors.lastname: Wechsler
mesh_terms: D001932:Brain Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002540:Cerebral Cortex / Q000473:pathology; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007376:Interleukin-2 / Q000008:administration & dosage*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology / Q000637:transplantation*; D008213:Lymphocyte Activation / Q000276:immunology; D009336:Necrosis; D009364:Neoplasm Recurrence, Local / Q000276:immunology / Q000473:pathology / Q000628:therapy
chemical_list: D007376:Interleukin-2