title: Isolation, NMR studies, and biological activities of onopordopicrin from Centaurea sonchifolia.
abstract: A sesquiterpene lactone, onopordopicrin [1], has been isolated from Centaurea sonchifolia. Its structure was established by 2D nmr (1H-1H and 13C-1H correlations), and the conformation in CHCl3 was examined by nOe studies. Cytotoxic, antibacterial, and antifungal activities are reported.
authors.affiliation: Department of Chemistry, University of New Brunswick, Fredericton, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Lonergan
authors.forename: E
authors.initials: E
authors.lastname: Routsi
authors.forename: T
authors.initials: T
authors.lastname: Georgiadis
authors.forename: G
authors.initials: G
authors.lastname: Agelis
authors.forename: J
authors.initials: J
authors.lastname: Hondrelis
authors.forename: J
authors.initials: J
authors.lastname: Matsoukas
authors.forename: L K
authors.initials: LK
authors.lastname: Larsen
authors.forename: F R
authors.initials: FR
authors.lastname: Caplan
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D001266:Atlantic Islands; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007783:Lactones / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D012717:Sesquiterpenes; C075494:onopordopicrin