title: The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist.
authors.affiliation: DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington, Delaware 19880-0402.
authors.forename: J V
authors.initials: JV
authors.lastname: Duncia
authors.forename: D J
authors.initials: DJ
authors.lastname: Carini
authors.forename: A T
authors.initials: AT
authors.lastname: Chiu
authors.forename: A L
authors.initials: AL
authors.lastname: Johnson
authors.forename: W A
authors.initials: WA
authors.lastname: Price
authors.forename: P C
authors.initials: PC
authors.lastname: Wong
authors.forename: R R
authors.initials: RR
authors.lastname: Wexler
authors.forename: P B
authors.initials: PB
authors.lastname: Timmermans
mesh_terms: D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001667:Binding, Competitive; D001713:Biphenyl Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000639:trends; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D016234:Kallikrein-Kinin System / Q000187:drug effects; D019808:Losartan; D008956:Models, Chemical; D011817:Rabbits; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects; D013777:Tetrazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D001713:Biphenyl Compounds; D007093:Imidazoles; D013777:Tetrazoles; D000804:Angiotensin II; D019808:Losartan