title: Validation of a HPLC method for the determination of bendazac and its main metabolite 5-hydroxybendazac in human plasma.
abstract: The purpose of this study was to validate an analytical method for the determination of bendazac and its main metabolite 5-hydroxybendazac in human plasma. The results obtained indicate that the method is reproducible, accurate, precise, sensitive and specific for the measurement of bendazac and 5-hydroxybendazac in the human plasma. Therefore it can be considered suitable for experimental purposes, routine application for drug monitoring and regulatory requirements.
authors.affiliation: Istituto Ricerca Francesco Angelini S.p.A., Rome, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Catanese
authors.forename: M
authors.initials: M
authors.lastname: Panei
authors.forename: R
authors.initials: R
authors.lastname: Picollo
authors.forename: B
authors.initials: B
authors.lastname: Martinelli
authors.forename: M G
authors.initials: MG
authors.lastname: Ciarniello
authors.forename: S
authors.initials: S
authors.lastname: Baravelli
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007191:Indazoles / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007191:Indazoles; C051605:5-hydroxybendazac; C000123:bendazac