Haemostatic activity of ethamsylate and aminocaproic acid adsorbed poly(2-hydroxyethyl methacrylate) particles.
A haemostatic material suitable for embolization was prepared by the adsorption of haemostatics--ethamsylate and aminocaproic acid in the spherical particles of porous poly(2-hydroxyethyl methacrylate) (p(HEMA)). The degree of purification of ethamsylate-treated particles was tested by an analysis of donor blood in contact with the material. An evaluation of the haemostatic properties of these materials was obtained by the determination of the indicators of blood clotting: activated partial thromboplastin time, thrombin time, and prothrombin time. Ethamsylate or aminocaproic acid-containing p(HEMA) has a distinct haemostatic effect on pathological blood of patients suffering from focal alterations of the liver. These haemostatic emboli materials show promise for the immediate control of various haemorrhages; when introduced into a zone with increased haemorrhage, they may help to correct disturbed haemostasis.
Horák
D
D
Institute of Macromolecular Chemistry, Czechoslovak Academy of Sciences, Prague.
Svec
F
F
Adamyan
A
A
Titova
M
M
Skuba
N
N
Voronkova
O
O
Trostenyuk
N
N
Vishnevskii
V
V
Gumargalieva
K
K
D000327:Adsorption; D000614:Aminocaproates; D001672:Biocompatible Materials; D004621:Embolization, Therapeutic / Q000379:methods*; D004979:Ethamsylate; D006470:Hemorrhage / Q000628:therapy; D006490:Hemostatics / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008107:Liver Diseases / Q000628:therapy; D008422:Materials Testing; D011102:Polyhydroxyethyl Methacrylate / Q000494:pharmacology*
D000614:Aminocaproates; D001672:Biocompatible Materials; D006490:Hemostatics; D004979:Ethamsylate; D011102:Polyhydroxyethyl Methacrylate