title: Hypocalcemic cardiomyopathy in a patient with idiopathic hypoparathyroidism.
abstract: An idiopathic hypoparathyroidism-induced cardiomyopathy patient had severe long-lasting hypocalcemia. The dramatic improvement of cardiac function with correction of only the serum calcium concentration could be quantitatively demonstrated on both echocardiogram and ventriculogram. The concentration of the extracellular calcium ion was considered to have a direct effect on the strength of the myocardial contraction through excitation-contraction coupling. Furthermore, elevated serum creatine phosphokinase and lactate dehydrogenase levels which were thought to be delivered from skeletal muscle returned to the normal range concomitant with the correction of hypocalcemia. The serum calcium concentration and these enzyme level showed significant inverse correlations.
authors.affiliation: Second Department of Internal Medicine, Sapporo Medical College, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Kudoh
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Marusaki
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: N
authors.initials: N
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Shimamoto
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
authors.forename: O
authors.initials: O
authors.lastname: Iimura
mesh_terms: D009202:Cardiomyopathies / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D003402:Creatine Kinase / Q000097:blood; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000209:etiology*; D007011:Hypoparathyroidism / Q000097:blood / Q000150:complications*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase