title: Aortic valve replacement. Aortic root versus coronary sinus perfusion with blood cardioplegic solution.
abstract: The role of retrograde coronary sinus cardioplegia in patients undergoing aortic valve replacement for aortic stenosis alone or in combination with myocardial revascularization has not been fully defined. Sixty-three patients undergoing elective aortic valve replacement received cold potassium blood cardioplegic solution via either the aortic root (36 patients) or the coronary sinus (27 patients). The patients were similar with respect to age, degree of aortic stenosis, ventricular function, severity of coronary artery disease, crossclamp time, completeness of revascularization, and mean volume and temperature of the infusion solution. The mean septal temperature and the release of myocardium-specific isoenzyme in the first 2 hours after crossclamp removal was higher in the retrograde group (p less than 0.008). Right and left ventricular function was preserved equally in the two groups, and volume-loading studies suggested improved diastolic performance in patients having retrograde cardioplegia. There were no differences between the two groups with respect to clinical outcome. We conclude that coronary sinus cardioplegia is as safe as aortic root perfusion for myocardial preservation in patients undergoing elective aortic valve replacement.
authors.affiliation: Department of Surgery, St. Louis University Medical Center, Mo.
authors.forename: A C
authors.initials: AC
authors.lastname: Fiore
authors.forename: K S
authors.initials: KS
authors.lastname: Naunheim
authors.forename: L R
authors.initials: LR
authors.lastname: McBride
authors.forename: D G
authors.initials: DG
authors.lastname: Pennington
authors.forename: G C
authors.initials: GC
authors.lastname: Kaiser
authors.forename: J
authors.initials: J
authors.lastname: Castanis
authors.forename: C J
authors.initials: CJ
authors.lastname: Daake
authors.forename: V L
authors.initials: VL
authors.lastname: Willman
authors.forename: H B
authors.initials: HB
authors.lastname: Barner
mesh_terms: D001011:Aorta; D001021:Aortic Valve; D001024:Aortic Valve Stenosis / Q000601:surgery*; D001769:Blood; D002314:Cardioplegic Solutions / Q000008:administration & dosage*; D003331:Coronary Vessels; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009204:Myocardial Revascularization
chemical_list: D002314:Cardioplegic Solutions