The prognostic value of DNA content measured by image cytometry in soft tissue sarcomas.
Nuclear DNA content in soft tissue sarcoma was determined by image cytometry using archival, paraffin embedded material. In a retrospective study 138 specimens of 81 patients have been analysed. The ploidy level was correlated to clinical outcome regarding tumor volume and histological grading, the most important prognostic parameters. Ploidy has a significant prognostic value and correlates well with histological grading (p = 0.01). Tumour volume was found to be an independent prognostic factor (p = greater than 0.1) [chi 2 test]. The DNA content of the primary tumour and of multiple local recurrences remained similar.
Pape
H
H
Department of Radiotherapy and Radiation Oncology, Heinrich Heine University Düsseldorf, FRG.
Pöttgen
C
C
Ploem
J S
JS
Van Driel-Kulker
A M
AM
Wurm
R
R
Schmitt
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000235:genetics*; D012983:Soft Tissue Neoplasms / Q000235:genetics*; D013690:Television
D004273:DNA, Neoplasm