title: Do burn patients have a silver lining?
abstract: Silver-containing pharmacological preparations have been used for many years in the prophylaxis and management of burn wound sepsis and, more recently, 1 per cent silver sulphadiazine cream (SSD) has been the treatment of choice for such problems. A prospective clinical study has been undertaken to determine the absorption and effects of the silver ion from SSD, with particular reference to hepatic and renal function. Twenty-two patients were studied. The silver assay was done by atomic absorption spectrophotometry with an attached graphite furnace. The detection level was 0.5 micrograms/l. The precision at 3.5 micrograms/l was 4.8 per cent and at 8.5 micrograms/l was 2.8 per cent. Silver was rapidly absorbed through the burn wound and serum silver levels were elevated in 20 patients. Silver was found to be deposited biochemically and electronmicrographically in the liver and kidneys of the only patient who died in the study group. Early hepatic dysfunction was present in all burns greater than 10 per cent total body surface area. Liver and renal function tests did not correlate with serum silver levels. A urinary threshold to silver excretion was seen at a serum silver level of 100 micrograms/l. This study demonstrates that silver is rapidly absorbed through burn wounds, is deposited in large amounts throughout the body but appears safe when used in the treatment of moderate burns. Whether the very high levels recorded in the subject who died were inherently detrimental will remain a matter for speculation.
authors.affiliation: Burns Unit, Alfred Hospital, Melbourne, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Coombs
authors.forename: A T
authors.initials: AT
authors.lastname: Wan
authors.forename: J P
authors.initials: JP
authors.lastname: Masterton
authors.forename: R A
authors.initials: RA
authors.lastname: Conyers
authors.forename: J
authors.initials: J
authors.lastname: Pedersen
authors.forename: Y T
authors.initials: YT
authors.lastname: Chia
mesh_terms: D000042:Absorption; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002056:Burns / Q000378:metabolism*; D005123:Eye / Q000378:metabolism; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000648:ultrastructure; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012834:Silver / Q000378:metabolism*; D012837:Silver Sulfadiazine / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014946:Wound Infection / Q000188:drug therapy
chemical_list: D012834:Silver; D012837:Silver Sulfadiazine