Transcription factors, translocations and haematological malignancies.
Haematological malignancies arise as a consequence of clonal evolution driven by an accumulation of somatic mutations. Many haematological malignancies are associated with chromosome translocations that have provided powerful tools for the identification of proto-oncogenes implicated in the pathogenesis of leukaemia/lymphoma. The recent characterisation of several translocation breakpoints associated with human haematological tumours has demonstrated that genes encoding transcription factors are frequently involved. Direct alteration of transcription factor activity by somatic mutation may represent a particularly powerful leukaemogenic event.
Green
A R
AR
University of Cambridge Dept of Haematology, MRC Centre, UK.
D015973:Gene Expression Regulation, Leukemic / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
D014157:Transcription Factors