title: The association of astrocytoma and pituitary adenoma in a patient with alcaptonuria.
abstract: A female patient with a juvenile pilocytic astrocytoma and a pituitary adenoma is described. The patient also has alcaptonuria, a rare inborn error of metabolism with autosomal recessive mode of inheritance. The association of these three disorders has never been reported previously. The possible existence of a common genetic factor in the development of both tumors and alcaptonuria is discussed.
authors.affiliation: Department of Endocrinology, University of Antwerp, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Abs
authors.forename: M
authors.initials: M
authors.lastname: Van Vyve
authors.forename: P J
authors.initials: PJ
authors.lastname: Willems
authors.forename: I
authors.initials: I
authors.lastname: Neetens
authors.forename: B
authors.initials: B
authors.lastname: Van der Auwera
authors.forename: E
authors.initials: E
authors.lastname: Van den Ende
authors.forename: E
authors.initials: E
authors.lastname: Van de Kelft
authors.forename: A
authors.initials: A
authors.lastname: Beckers
authors.forename: E
authors.initials: E
authors.lastname: Van Marck
authors.forename: J J
authors.initials: JJ
authors.lastname: Martin
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000235:genetics; D000328:Adult; D000474:Alkaptonuria / Q000150:complications* / Q000235:genetics; D001254:Astrocytoma / Q000150:complications* / Q000235:genetics; D001932:Brain Neoplasms / Q000150:complications* / Q000235:genetics; D003388:Cranial Fossa, Posterior; D005260:Female; D016147:Genes, Tumor Suppressor; D020022:Genetic Predisposition to Disease; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000235:genetics; D010911:Pituitary Neoplasms / Q000150:complications* / Q000235:genetics