Biosynthesis of glyantrypine by Aspergillus clavatus.
The biosynthesis of glyantrypine from radiolabelled amino acid precursors has been shown experimentally to involve anthranilic acid, tryptophan and glycine. Low values for percentage incorporation of radiolabel into glyantrypine were partly influenced by a complex array of other novel alkaloids shown by the radiolabelling experiments to be related to glyantrypine. Interpretation of radiolabel incorporation from [14C-carboxyl]-anthranilic acid into microbial metabolites seen to contain an anthranilyl moiety in various biosynthetic arrangements is discussed. The possibility of diversion of anthranilic acid from the kynurenine pathway to glyantrypine biosynthesis is recognised.
Penn
J
J
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, UK.
Purcell
M
M
Mantle
P G
PG
D000470:Alkaloids / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D001230:Aspergillus / Q000254:growth & development / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D011799:Quinazolines / Q000378:metabolism*; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000378:metabolism; D062367:ortho-Aminobenzoates / Q000378:metabolism
D000470:Alkaloids; D000596:Amino Acids; D011799:Quinazolines; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; C075514:glyantrypine; D014364:Tryptophan; D005998:Glycine