Biosynthesis of TXB2 and 6-oxo-PGF1 alpha in the heart and other tissues under pathophysiological conditions.
Many organs have the capacity to form prostanoids. Under pathophysiological conditions the biosynthesis of TXB2 and 6-oxo-PGF1 alpha is markedly increased in the myocardium and the gastric mucosa. Tumor growth is linked with an enhanced prostanoid formation. Furthermore a rise of the PG content could be found in the liquor, aqueous humor and urine under diseases of the related organs. These results could be of some significance for diagnosis and therapy control.
Mentz
P
P
Department of Pharmacology and Toxicology, Martin-Luther-University Halle.
Giessler
C
C
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis* / Q000652:urine; D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001927:Brain Diseases / Q000378:metabolism; D002648:Child; D005753:Gastric Mucosa / Q000378:metabolism; D005756:Gastritis / Q000378:metabolism; D006168:Guinea Pigs; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D006975:Hypertension, Portal / Q000378:metabolism; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D016030:Kidney Transplantation / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism; D013929:Thromboxane B2 / Q000096:biosynthesis* / Q000652:urine
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D007213:Indomethacin