Choline: a conditionally essential nutrient for humans.
Tissue concentrations of choline decreased significantly while serum alanine aminotransferase activity, a marker of liver injury, increased sharply (by 50%) when healthy young adult men received a choline-free semisynthetic diet for three weeks. This study suggests that choline is an essential nutrient for humans when excess methionine and folate are not available in the diet.
D000410:Alanine Transaminase / Q000097:blood; D002794:Choline / Q000502:physiology*; D002796:Choline Deficiency / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000503:physiopathology*
D000410:Alanine Transaminase; D002794:Choline