[Familial primary generalized epilepsy and drug (anticonvulsant)-induced systemic lupus erythematosus--a family study].
We report a 12-year study of a family with high mortality rate due to primary generalized epilepsy. During indicated and non-indicated therapy with anticonvulsive drugs (succinimides and hydantoines) there developed symptoms of systematic lupus erythematosus. The value of controlled immunological and genetic markers is discussed.
Quietzsch
J
J
Kinderklinik, Städtischen Kliniken Chemnitz.
Baumgarten
C
C
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D010375:Pedigree; D010641:Phenotype
D000927:Anticonvulsants; D006680:HLA Antigens
Familiäre primär generalisierte Epilepsie und medikamentös (antikonvulsiv) ausgelöster systemischer Lupus erythematodes--Eine Familienstudie.