Platelets and blood vessels: the adhesion event.
Circulating blood platelets attach to damaged blood vessels by specific adhesion molecules. In the human arterial circulation, a unique 'shear-dependent' mechanism governs adhesion by a single receptor-ligand (glycoprotein Ib-von Willebrand factor) pair. Here, Gerald Roth reviews recent data that provide insights into the functions of these molecules.
Roth
G J
GJ
Hematology Section, Seattle Veterans Hospital, WA.
D000595:Amino Acid Sequence; D001777:Blood Coagulation; D001792:Blood Platelets / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins / Q000502:physiology; D014841:von Willebrand Factor / Q000502:physiology
D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor