title: Spontaneous remission of a third-nerve palsy in meningeal lymphoma.
abstract: We report on a patient with spontaneous remission of a third-nerve palsy who was subsequently found to have meningeal lymphoma. Initial magnetic resonance images (MRI) showed bilateral enhancement of the third nerves. Follow-up MRI 7 months later, without treatment, showed complete resolution. One year after initial presentation, the patient developed multiple lumbosacral radiculopathies and examination of a nerve root biopsy specimen disclosed a B-cell lymphoma. Serial cerebrospinal fluid analyses over the previous year showed occasional atypical cells, later found to resemble closely the biopsy cell type. We conclude that meningeal lymphoma may have a protracted course, with spontaneous remission of both clinical and neuroimaging findings.
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: S L
authors.initials: SL
authors.lastname: Galetta
authors.forename: R C
authors.initials: RC
authors.lastname: Sergott
authors.forename: G B
authors.initials: GB
authors.lastname: Wells
authors.forename: S W
authors.initials: SW
authors.lastname: Atlas
authors.forename: S J
authors.initials: SJ
authors.lastname: Bird
mesh_terms: D000368:Aged; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008223:Lymphoma / Q000150:complications*; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications*; D009802:Oculomotor Nerve; D010243:Paralysis / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012075:Remission, Spontaneous