title: Clinicopathologic study of perineural invasion in rectal cancer.
abstract: Perineural invasion (PNI) in rectal cancer was studied, prospectively. One-hundred patients (20%) were identified as having tumors with PNI. The incidence of PNI was significantly increased in tumors with moderate or marked venous invasion (30%, 64%), with moderate or marked lymphatic permeation (37%, 72%), with liver metastasis (50%) and with peritoneal dissemination (64%). In cases of curative surgery, the incidence of PNI was significantly increased in MAC stage C2m+g or C3 (28%, 35%). There was no significant difference in the recurrence or survival rates between the patients with PNI and without PNI in MAC stage B2m+g. However, there was a significant increase in local recurrence in the patients with both PNI and lymph node metastasis (p less than 0.05). Also, the patients with PNI in MAC stage C2m+g had a significantly lower 8-year survival rate (29.1%, p less than 0.001). Multivariate analysis using Cox regression models demonstrated that PNI was an independent prognostic factor for survival.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shirouzu
authors.forename: H
authors.initials: H
authors.lastname: Isomoto
authors.forename: T
authors.initials: T
authors.lastname: Morodomi
authors.forename: Y
authors.initials: Y
authors.lastname: Araki
authors.forename: M
authors.initials: M
authors.lastname: Hoshiko
authors.forename: Y
authors.initials: Y
authors.lastname: Akagi
authors.forename: T
authors.initials: T
authors.lastname: Sasatomi
authors.forename: T
authors.initials: T
authors.lastname: Kakegawa
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D010525:Peripheral Nerves / Q000473:pathology; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate