title: Mouse macrophages contain a truncated CD4 transcript.
abstract: Mouse macrophages do not express CD4 on their surfaces. We used the polymerase chain reaction to investigate CD4 gene transcription in individual clones of primary mouse splenic macrophages and cell lines of spleen and bone marrow macrophages. The results show only the presence of CD4 mRNA transcripts that are truncated in the 3' coding sequence, thus explaining the lack of expression of a mature CD4 gene product by these cells.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101-0318.
authors.forename: S C
authors.initials: SC
authors.lastname: Moore
authors.forename: S J
authors.initials: SJ
authors.lastname: Anderson
authors.forename: W S
authors.initials: WS
authors.lastname: Walker
mesh_terms: D000818:Animals; D001483:Base Sequence; D015704:CD4 Antigens / Q000097:blood* / Q000235:genetics*; D005091:Exons; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D014158:Transcription, Genetic
chemical_list: D015704:CD4 Antigens