Distribution of isoniazid in an overdose death.
A fatality due to the ingestion of isoniazid, a tuberculostatic agent, is presented. Isoniazid was extracted by a single step extraction procedure, derivatized with trifluoroacetic anhydride, and identified and quantified by gas chromatography/mass spectrometry (GC/MS). The distribution of isoniazid was as follows: heart blood 43 mg/L, subclavian blood 94 mg/L, urine 470 mg/L, bile 900 mg/L, liver 650 mg/Kg, kidney 110 mg/Kg, and stomach contents 4 mg.
LoDico
C P
CP
Office of the Chief Medical Examiner, Toxicology Laboratory, Baltimore, Maryland 21201.
Levine
B S
BS
Goldberger
B A
BA
Caplan
Y H
YH
D000293:Adolescent; D000328:Adult; D003643:Death; D062787:Drug Overdose / Q000150:complications; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007538:Isoniazid / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning; D008297:Male; D011180:Postmortem Changes; D014018:Tissue Distribution
D007538:Isoniazid