title: Potential pathogenicity for rodents of vaccines intended for oral vaccination against rabies: a comparison.
abstract: Different oral vaccines intended to control fox rabies were administered to 271 wild rodents. Vaccines were administered orally or by the mucosal route to four different European species belonging to the genera Apodemus, Arvicola, Clethrionomys and Microtus. These rodents are likely to consume baits and to have contact with the vaccine. Two genetically engineered vaccines were tested: SAG1 (an avirulent mutant of the rabies virus) and V-RG (vaccinia recombinant virus expressing the rabies glycoprotein gene). Both were found to be completely innocuous when administered orally or by the mucosal route. The residual pathogenicity of conventional modified live vaccines derived from the SAD strain was confirmed.
authors.affiliation: CNEVA, LERPAS, BP 9, Malzéville, France.
authors.forename: M
authors.initials: M
authors.lastname: Artois
authors.forename: C
authors.initials: C
authors.lastname: Guittré
authors.forename: I
authors.initials: I
authors.lastname: Thomas
authors.forename: H
authors.initials: H
authors.lastname: Leblois
authors.forename: B
authors.initials: B
authors.lastname: Brochier
authors.forename: J
authors.initials: J
authors.lastname: Barrat
mesh_terms: D000284:Administration, Oral; D000818:Animals; D011819:Rabies Vaccines / Q000009:adverse effects*; D012377:Rodentia / Q000502:physiology*; D014611:Vaccination
chemical_list: D011819:Rabies Vaccines