title: Cellular regeneration and recovery of the maxillary sinus mucosa. An experimental study in rabbits.
abstract: Unilateral maxillary sinusitis was induced in 30 New Zealand White rabbits with Streptococcus pneumoniae or Bacteroides fragilis. In another group of 15 rabbits without infection, the sinus mucosa was surgically removed in defined areas. In both series, the sinuses were serially sectioned for histological analysis of the cellular regenerative capacity. In maxillary sinusitis induced by Bacteroides fragilis, an inflammatory and also reparative process involving all mucosal layers including the underlying periosteum was seen. The more superficial trauma as found in pneumococcal sinusitis eventually led to restitution ad integrum. Following surgical removal, the denuded sinus-lining was reepithelized by a flattened ciliated epithelium on a lamina propria displaying fibrosis and lacking serous glands. The restoration of the rabbit maxillary sinus mucosa after surgical trauma thus leads to structural abnormalities of the epithelium as well as the lamina propria, and these changes are likely to interfere with the normal function of the sinus mucosa.
authors.affiliation: Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Norlander
authors.forename: K
authors.initials: K
authors.lastname: Forsgren
authors.forename: J
authors.initials: J
authors.lastname: Kumlien
authors.forename: P
authors.initials: P
authors.lastname: Stierna
authors.forename: B
authors.initials: B
authors.lastname: Carlsöö
mesh_terms: D000818:Animals; D001442:Bacteroides Infections / Q000473:pathology; D001441:Bacteroides fragilis; D002455:Cell Division; D004195:Disease Models, Animal; D015523:Maxillary Sinusitis / Q000382:microbiology / Q000473:pathology*; D009297:Nasal Mucosa / Q000473:pathology*; D011008:Pneumococcal Infections / Q000473:pathology; D011817:Rabbits