title: Rapid administration of crystalloid preload does not decrease the incidence of hypotension after spinal anaesthesia for elective caesarean section.
abstract: Twenty parturients undergoing elective Caesarean section were allocated randomly to receive crystalloid preload 20 ml kg-1 over either 20 min or 10 min before spinal anaesthesia. Significant hypotension (systolic arterial pressure less than 100 mm Hg and less than 80% of baseline value) occurred in six of the 10 patients in the 20-min preload group and seven of 10 patients in the 10-min preload group (ns). Both groups had a significant (P less than 0.05) increase in central venous pressure during the preload period. The mean central venous pressure in the 10-min group was 11.9 mm Hg (range 6-19 mm Hg), which was significantly greater (P less than 0.05) than that in the 20-min group (mean 7.3 mm Hg, range 2-13 mm Hg). Three patients in the 10-min group had clinically unacceptable increases in central venous pressure. This study has demonstrated that rapid administration of crystalloid preload before spinal anaesthesia did not decrease the incidence or severity of hypotension, and questions the role of crystalloid preload.
authors.affiliation: Department of Anaesthetics, University of Natal.
authors.forename: C C
authors.initials: CC
authors.lastname: Rout
authors.forename: S S
authors.initials: SS
authors.lastname: Akoojee
authors.forename: D A
authors.initials: DA
authors.lastname: Rocke
authors.forename: E
authors.initials: E
authors.lastname: Gouws
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D001794:Blood Pressure; D002496:Central Venous Pressure; D002585:Cesarean Section; D000077324:Crystalloid Solutions; D005260:Female; D005440:Fluid Therapy; D006339:Heart Rate; D006801:Humans; D007022:Hypotension / Q000517:prevention & control*; D007552:Isotonic Solutions; D010952:Plasma Substitutes / Q000008:administration & dosage; D011247:Pregnancy; D011897:Random Allocation
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D010952:Plasma Substitutes