title: Pharmacokinetics of diphemanil methylsulphate in healthy subjects.
abstract: The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.
authors.affiliation: Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
authors.forename: A M
authors.initials: AM
authors.lastname: Vidal
authors.forename: E
authors.initials: E
authors.lastname: Rey
authors.forename: G
authors.initials: G
authors.lastname: Pons
authors.forename: J Y
authors.initials: JY
authors.lastname: Pello
authors.forename: P
authors.initials: P
authors.lastname: d'Athis
authors.forename: G
authors.initials: G
authors.lastname: Olive
mesh_terms: D000284:Administration, Oral; D000328:Adult; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010880:Piperidines / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D010880:Piperidines; C028209:diphemanil methylsulfate