Intraperitoneal administration of recombinant human interleukin-1 beta inhibits osmotic thirst in the rat.
Decrease in water intake after intraperitoneal injection of interleukin-1 beta (IL-1 beta) was studied in the rat. Administration of IL-1 beta at a dose of 20 micrograms/kg attenuated osmotic thirst induced by intraperitoneal injection of hypertonic saline, but did not affect hypovolemic thirst induced by subcutaneous injection of either polyethylene glycol or angiotensin II. Interleukin-1 beta also decreased spontaneous intake of water but not that of 1.8% saline. The results suggest that the decrease in water intake by IL-1 beta is caused, at least in part, by suppression of osmotic thirst but not by general suppression of behavior. The effects of IL-1 beta were not secondary responses accompanied by feeding behavior, since food supply was removed during the experiments. Pretreatment with indomethacin blocked the decrease in water intake by IL-1 beta, suggesting the involvement of production of prostaglandins.
Osaka
T
T
Department of Physiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kannan
H
H
Kawano
S
S
Ueta
Y
Y
Yamashita
H
H
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D004326:Drinking / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012462:Saline Solution, Hypertonic; D013649:Taste / Q000187:drug effects; D013894:Thirst / Q000187:drug effects*
D007375:Interleukin-1; D011994:Recombinant Proteins; D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D011092:Polyethylene Glycols; D007213:Indomethacin