Food contains the bioactive peptide, cyclo(His-Pro).
Cyclo(His-Pro) (CHP) is a cyclic dipeptide with numerous biological activities. As small di- and tripeptides may be absorbed intact when ingested orally, we were interested in examining several common foods for the presence of cyclo(His-Pro)-like immunoreactivity (CHP-LI). In all foods tested, CHP-LI was found at levels 5-1500 times those previously found in human plasma. This CHP-LI was identical to authentic CHP by immunoidentity and chromatographic behavior. We conclude that 1) CHP-LI is readily detectable in several common food sources; 2) this CHP-LI is indistinguishable from authentic CHP; and 3) it is likely the CHP-LI in foods is absorbed in quantities sufficient to cause elevations of CHP-LI in plasma to biologically significant levels.
Hilton
C W
CW
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Prasad
C
C
Vo
P
P
Mouton
C
C
D002845:Chromatography; D005502:Food; D009994:Osmolar Concentration; D010456:Peptides, Cyclic / Q000032:analysis*; D010879:Piperazines / Q000032:analysis*; D011863:Radioimmunoassay
D010456:Peptides, Cyclic; D010879:Piperazines; C015924:histidyl-proline diketopiperazine