Anticonvulsant-induced chronic pancreatitis. A case report.
We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin. Long-term anticonvulsant drug therapy may have a contributory role in the development of chronic pancreatitis by chronic stimulation of cytochromes P-450.
Pezzilli
R
R
Servizio di Pronto Soccorso, Ospedale S. Orsola, Bologna, Italy.
Billi
P
P
Melandri
R
R
Broccoli
P L
PL
Fontana
G
G
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects; D002908:Chronic Disease; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D010672:Phenytoin / Q000009:adverse effects; D014635:Valproic Acid / Q000009:adverse effects
D000927:Anticonvulsants; D005609:Free Radicals; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System