title: Sensitivity of transmission probabilities to paternity exclusion in segregation analysis.
abstract: Paternity exclusions are known to be common in Western countries and are yet neglected in segregation analysis because it is almost impossible to check it systematically on a large family sample. We had the opportunity of observing the sensitivity of segregation analysis parameters to a paternity exclusion in analyzing 34 families for a simple Mendelian trait, the acetylator phenotype. We found that only one family, with proven paternity exclusion, was responsible for a strong rejection of Mendelian transmission probabilities (P much much less than 0.001).
authors.affiliation: Unité de Recherche d'Epidémiologie Génétique (U 155 INSERM), Château de Longchamp, Bois de Boulogne, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bonaïti-Pellié
authors.forename: N
authors.initials: N
authors.lastname: Poisson
authors.forename: Y
authors.initials: Y
authors.lastname: Bechtel
authors.forename: P
authors.initials: P
authors.lastname: Bechtel
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D002110:Caffeine / Q000378:metabolism; D005192:Family Health; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D010334:Paternity; D010641:Phenotype; D011336:Probability; D012680:Sensitivity and Specificity
chemical_list: D002110:Caffeine; D000123:Acetyltransferases