Bone marrow regeneration under cytotoxic drug regimens: behaviour ranging from homeostasis to unpredictability in a model for hemopoietic differentiation.
In the process of hemopoiesis, bone marrow stem cells differentiate into the various types of mature blood cells. We present a model for bone marrow dynamics, which retrieves its ability to continuously modulate the balance between self-renewal and differentiation, even under periodic cytodestructive perturbations. Yet, a temporally stochastic perturbation results in chaotic-like behaviour which has no deterministic source.
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Department of Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.
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D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D013269:Stochastic Processes
D000970:Antineoplastic Agents