title: Local and systemic influenza haemagglutinin-specific antibody responses following aerosol and subcutaneous administration of inactivated split influenza vaccine.
abstract: An easily administered and safe vaccine is required to produce the herd immunity necessary to control influenza epidemics worldwide. A commercial quadrivalent inactivated split influenza vaccine was administered intranasally in aerosol form to a group of 46 volunteers; other groups were given the same vaccine subcutaneously and saline intranasally. The results show that mucosal stimulation via intranasal vaccination resulted in a marked increase in local HA-specific IgA antibodies, and that this stimulation was necessary for serum HA-specific IgA responses. Serum HA-specific IgA antibody levels can be used as indicators of local antigenic stimulation, providing a method for evaluating potency and antigenicity in humans of intranasal influenza vaccine. This vaccination route shows much promise for the future.
authors.affiliation: Department of Pediatrics, School of Medicine, Tokai University, Kanagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Oh
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Kuno-Sakai
authors.forename: R
authors.initials: R
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Kimura
mesh_terms: D000328:Adult; D000336:Aerosols; D000914:Antibodies, Viral / Q000032:analysis*; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007252:Influenza Vaccines / Q000276:immunology*; D007279:Injections, Subcutaneous; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D000336:Aerosols; D000914:Antibodies, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated