A patient with monosomy 7 and polyuria.
Diabetes insipidus (DI) is a rare complication of leukaemia. An association between monosomy 7 and DI in leukaemias has been proposed. We present a case of Ph1-positive CML who developed polyuria at the time of lymphoid blast transformation associated with loss of chromosome 7. Biochemical results were not diagnostic of DI and a therapeutic trial of DDAVP was unsuccessful. Post-mortem showed a peripituitary and renal leukaemic infiltrate and although DI is a possibility, the cause of his polyuria remains unresolved.
Sadullah
S
S
Department of Haematology, Royal Victoria Hospital, Bournemouth, U.K.
Kruger
A R
AR
Barrington Onslow
S
S
Armitage
M
M
Oscier
D G
DG
D001752:Blast Crisis / Q000150:complications / Q000235:genetics / Q000473:pathology; D002897:Chromosomes, Human, Pair 7; D003919:Diabetes Insipidus / Q000150:complications / Q000235:genetics; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000235:genetics / Q000473:pathology; D015466:Leukemia, Myeloid, Chronic-Phase / Q000150:complications / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D011141:Polyuria / Q000150:complications* / Q000235:genetics