title: Ceramide composition of whole brain synaptosomal gangliosides from mice genetically bred for divergent ethanol sensitivities.
abstract: A comparison of the two major ceramide molecular species (d18:1-C18:0 and d20:1-C18:0) of synaptosomal gangliosides GM1, GD1a+GT1a, GD1b, GT1b, revealed a difference between the ceramide composition of ethanol-sensitive LS and ethanol-insensitive SS whole brain synaptosomal gangliosides. In all comparisons, the ratio of the two major molecular species, (d18:1-C18:0/d20:1-C18:0) was less for LS than for SS mice.
authors.affiliation: Research Service/GRECC, ENRM Veterans Hospital, Bedford, MA 01730.
authors.forename: M D
authors.initials: MD
authors.lastname: Ullman
authors.forename: R F
authors.initials: RF
authors.lastname: Ventura
authors.forename: L J
authors.initials: LJ
authors.lastname: Draski
authors.forename: R A
authors.initials: RA
authors.lastname: Deitrich
authors.forename: R C
authors.initials: RC
authors.lastname: Baker
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D002518:Ceramides / Q000032:analysis*; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005732:Gangliosides / Q000032:analysis*; D051379:Mice; D013574:Synaptosomes / Q000737:chemistry*
chemical_list: D002518:Ceramides; D005732:Gangliosides; D000431:Ethanol