title: The course of severe foot infection in patients with diabetes.
abstract: Infection of the foot is a limb threatening condition for patients with diabetes mellitus. Identification of patients with diabetes and severe infection of the foot most likely to benefit from early revascularization or major amputation would improve the results of a treatment policy to prevent limb loss and avoid futile delays in amputation. During a nine year period, 79 diabetic patients underwent emergency procedures for severe infection of the foot during the initial hospitalization period. None of the patients underwent arterial reconstruction. Eventually, 21 of the patients required a major amputation, eight during the initial hospitalization and 13 on a subsequent admission. Stepwise discriminant analysis of clinical independent variables revealed that the patients most likely to require a major amputation during the initial hospitalization were those with an absent dorsalis pedis pulse and a polymicrobial infection (p = 0.018). The overall amputation rate (immediate or subsequent amputation) was higher for patients of either sex with nonpalpable pedal pulses when compared with those with at least one palpable pulse (p less than 0.05). Males who were not dependent on insulin had the highest risk of overall limb loss (p = 0.01). Patients undergoing delayed amputation required a significantly higher number (p = 0.01) of readmissions to the hospital for recurrent infection of the foot than those who did not undergo amputation. Data in the current study suggest that early major amputation in a subset of patients would prevent delay in the rehabilitation process of the amputee, decrease long term morbidity and reduce health care cost. An aggressive policy of early revascularization in patients with a pulse deficit may reduce the amputation rate in those with diabetes with severe infection of the foot.
authors.affiliation: Department of Surgery, University of North Carolina, Chapel Hill 27599-7210.
authors.forename: E
authors.initials: E
authors.lastname: Criado
authors.forename: A A
authors.initials: AA
authors.lastname: De Stefano
authors.forename: B A
authors.initials: BA
authors.lastname: Keagy
authors.forename: G R
authors.initials: GR
authors.lastname: Upchurch
authors.forename: G
authors.initials: G
authors.lastname: Johnson
mesh_terms: D000671:Amputation, Surgical; D001424:Bacterial Infections / Q000453:epidemiology / Q000601:surgery*; D003646:Debridement; D048909:Diabetes Complications; D005260:Female; D005528:Foot / Q000098:blood supply; D016523:Foot Ulcer / Q000453:epidemiology / Q000382:microbiology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009657:North Carolina / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors