title: c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development.
abstract: The c-ros proto-oncogene is the vertebrate homologue of the Drosophila sevenless tyrosine kinase receptor. Examination of c-ros mRNA transcripts in the mouse embryo reveals a stringent pattern of expression. Only kidney, intestine and lung exhibit ros-specific RNA using sensitive techniques such as RNAase protection and in situ hybridization. The temporal and spatial arrangement of c-ros transcripts is coincident with the phenotypic induction and proliferation of epithelium during organogenesis of the kidney and intestine. The data provide evidence for a role of c-ros in the obligate cell-cell interactions that characterize the morphogenic induction and proliferation of epithelial cells in the kidney, intestine and lung. The c-ros tyrosine kinase receptor may provide a signal transduction pathway for epithelial-mesenchymal interactions.
authors.affiliation: Molecular Embryology Section, NCI-Frederick Cancer Research and Development Center, MD 21702-1201.
authors.forename: L
authors.initials: L
authors.lastname: Tessarollo
authors.forename: L
authors.initials: L
authors.lastname: Nagarajan
authors.forename: L F
authors.initials: LF
authors.lastname: Parada
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D004627:Embryonic Induction / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D007422:Intestines / Q000196:embryology*; D007668:Kidney / Q000196:embryology*; D051379:Mice; D008815:Mice, Inbred Strains; D015336:Molecular Probe Techniques; D009693:Nucleic Acid Hybridization; D011505:Protein-Tyrosine Kinases; D011519:Proto-Oncogenes / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D011505:Protein-Tyrosine Kinases