title: Anti-IgG autoantibodies in HIV-infected hemophilia patients.
abstract: Sera of 76 HIV-negative hemophilia patients, 103 HIV-positive (HIV+) hemophilia patients free of AIDS or AIDS related complex (ARC), and 32 HIV+ hemophilia patients with AIDS/ARC were tested for four different anti-IgG activities. IgG-anti-F(ab')2 gamma, IgM-anti-F(ab')2 gamma, and IgG-anti-Fc gamma serum activities were significantly associated with the clinical stage of HIV infection, whereas IgM-anti-Fc gamma was not. IgG-anti-F(ab')2 gamma activity was found to be caused by cross-reaction of anti-HIV antibody with an epitope within the constant CH1 domain of human IgG. HIV+ hemophilia patients with severe thrombocytopenia (less than 50,000/microliters platelet counts) had significantly higher IgM-anti-IgG activity than patients with greater than 50,000/microliters platelets. Because anti-IgG antibodies possess immunoregulatory properties, our results may serve as a possible explanation for the frequent B cell disorders encountered in HIV-infected patients.
authors.affiliation: Department of Transplantation Immunology, University of Heidelberg, FRG.
authors.forename: C
authors.initials: C
authors.lastname: Süsal
authors.forename: I V
authors.initials: IV
authors.lastname: Lewin
authors.forename: D R
authors.initials: DR
authors.lastname: Stanworth
authors.forename: P
authors.initials: P
authors.lastname: Terness
authors.forename: V
authors.initials: V
authors.lastname: Daniel
authors.forename: H H
authors.initials: HH
authors.lastname: Oberg
authors.forename: A
authors.initials: A
authors.lastname: Huth-Kühne
authors.forename: R
authors.initials: R
authors.lastname: Zimmermann
authors.forename: G
authors.initials: G
authors.lastname: Opelz
mesh_terms: D000386:AIDS-Related Complex / Q000097:blood / Q000150:complications / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology; D000361:Agammaglobulinemia / Q000209:etiology / Q000276:immunology; D000595:Amino Acid Sequence; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D003429:Cross Reactions; D005803:Genes, Immunoglobulin; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000276:immunology*; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D015699:HIV Envelope Protein gp120; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007075:Immunoglobulin M