Comparison of nicardipine and sodium nitroprusside in the treatment of hypertension after coronary bypass surgery (a pilot study).
Sodium nitroprusside is widely used in the treatment of hypertension after coronary artery bypass surgery despite its toxicity and its deleterious effect on the coronary circulation. The aim of this study was to compare the safety and effectiveness of nicardipine with sodium nitroprusside in a randomized study. Nicardipine and sodium nitroprusside are effective for controlling hypertension after coronary artery surgery. Oxygen myocardial balance was more often improved by nicardipine than by sodium nitroprusside. Hemodynamic stability was better with nicardipine which was also devoid of toxicity and might therefore have advantages over sodium nitroprusside in the management of hypertension after coronary artery surgery.
Combes
P
P
Département d'Anesthésie-Réanimation 1, Centre Hospitalier Universitaire de Grenoble, France.
Durand
M
M
D000368:Aged; D001026:Coronary Artery Bypass; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008875:Middle Aged; D009529:Nicardipine / Q000009:adverse effects / Q000627:therapeutic use*; D009599:Nitroprusside / Q000009:adverse effects / Q000627:therapeutic use*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000188:drug therapy
D009599:Nitroprusside; D009529:Nicardipine