title: The catecholamine response to multisystem trauma.
abstract: We studied the catecholamine response in two groups of patients with multisystem injuries according to the presence (group 1, N = 124) or absence (group 2, N = 82) of head injury. Markers of injury severity included the injury Severity Score, the Glasgow Coma Scale, the need for intubation, admission hypotension, the amount of blood products and fluid expanders administered during the first 24 hours, and patient outcome. In group 1, higher norepinephrine levels always and epinephrine concentrations usually were associated with worsening indexes of injury severity. The best correlations were between the Injury Severity Score and the Glasgow Coma Scale and norepinephrine concentrations. In group 2, despite elevated catecholamine levels, such associations were seldom present. Thus, circulating catecholamine levels, especially norepinephrine levels, significantly correlated with the severity of injury in patients who had suffered multisystem injury, but only if the injury included the brain.
authors.affiliation: Departments of Medicine, University of Rochester School of Medicine, NY.
authors.forename: P D
authors.initials: PD
authors.lastname: Woolf
authors.forename: J V
authors.initials: JV
authors.lastname: McDonald
authors.forename: D V
authors.initials: DV
authors.lastname: Feliciano
authors.forename: M M
authors.initials: MM
authors.lastname: Kelly
authors.forename: D
authors.initials: D
authors.lastname: Nichols
authors.forename: C
authors.initials: C
authors.lastname: Cox
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006259:Craniocerebral Trauma / Q000097:blood* / Q000401:mortality; D004837:Epinephrine / Q000097:blood*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood* / Q000401:mortality; D009638:Norepinephrine / Q000097:blood*; D012720:Severity of Illness Index; D016019:Survival Analysis
chemical_list: D009638:Norepinephrine; D004837:Epinephrine