White blood cell immunization and anticardiolipin antibody levels in women with recurrent miscarriages.
To determine whether WBC immunization stimulates production of anticardiolipin antibodies, anticardiolipin antibodies were measured before and 6 weeks after WBC immunization. Twenty-four non-pregnant women, who had had recurrent miscarriages for which a definitive cause could not be determined, were immunized with their partner's WBC. No significant differences in levels of anticardiolipin antibodies were detected between paired samples of sera obtained before and 6 weeks after WBC immunization. White cell immunization in nonpregnant women did not stimulate production of anticardiolipin antibodies.
Doherty
R A
RA
Foundation for Blood Research, Scarborough, Maine 04070-0190.
Stubblefield
P
P
Dostal-Johnson
D A
DA
Day
G J
GJ
D000026:Abortion, Habitual / Q000097:blood / Q000276:immunology*; D000906:Antibodies / Q000032:analysis; D002308:Cardiolipins / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007114:Immunization; D007075:Immunoglobulin M / Q000032:analysis; D007962:Leukocytes / Q000276:immunology*; D011247:Pregnancy
D000906:Antibodies; D002308:Cardiolipins; D007075:Immunoglobulin M