title: A randomized trial of nimodipine in severe head injury: HIT I. British/Finnish Co-operative Head Injury Trial Group.
abstract: We studied the efficacy of nimodipine in severely head-injured patients in a randomized study. Of 176 patients who received nimodipine, 2 mg/h iv for 2 day, 53% had a favorable outcome (moderate or good recovery). Of 175 control patients, 49% had a favorable outcome. This difference was not statistically significant but does not exclude the possibility that a study of a larger number of patients could show a clinically useful benefit.
authors.affiliation: Department of Neurosurgery, Royal Victoria Hospital, Belfast.
authors.forename: G
authors.initials: G
authors.lastname: Teasdale
authors.forename: I
authors.initials: I
authors.lastname: Bailey
authors.forename: A
authors.initials: A
authors.lastname: Bell
authors.forename: J
authors.initials: J
authors.lastname: Gray
authors.forename: R
authors.initials: R
authors.lastname: Gullan
authors.forename: O
authors.initials: O
authors.lastname: Heiskanan
authors.forename: P V
authors.initials: PV
authors.lastname: Marks
authors.forename: H
authors.initials: H
authors.lastname: Marsh
authors.forename: D A
authors.initials: DA
authors.lastname: Mendelow
authors.forename: G
authors.initials: G
authors.lastname: Murray
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D009043:Motor Activity; D009553:Nimodipine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D009553:Nimodipine