[Role of exogenous fibrinogen in the processes of degranulation of thrombocytes stimulated with thrombin. Ultrastructural study using fibrinogen labeled with colloidal gold].
Using colloidal gold-conjugated fibrinogen (F-Au) it is shown that exogenous fibrinogen can participate in the platelet release reaction. In the absence of F-Au, internal secretory vacuoles readily formed in human platelets stimulated with thrombin, but extrusion of their content was delayed. Upon incubation with F-Au, endocytic channels induced by F-Au-receptor interactions, fused with internal vacuoles, thus establishing spatial communications of the latter with the outer medium.
Belitser
N V
NV
Anishchuk
M G
MG
Veklich
Iu I
IuI
Smekhova
T R
TR
Pozdniakova
T M
TM
Gorkun
O V
OV
Chernyshenko
T M
TM
Moroz
E D
ED
D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D015550:Cell Degranulation / Q000187:drug effects; D005340:Fibrinogen / Q000494:pharmacology*; D006046:Gold; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D013917:Thrombin / Q000494:pharmacology*; D014617:Vacuoles / Q000187:drug effects / Q000648:ultrastructure
D006046:Gold; D005340:Fibrinogen; D013917:Thrombin
Rol' ékzogennogo fibrinogena v protsessakh degranuliatsii trombotsitov, stimulirovannykh trombinom. Ul'trastrukturnoe issledovanie s primeneniem fibrinogena, mechennogo kolloidnym zolotom.