title: Somatic movement and oesophageal motility during isoflurane anaesthesia.
abstract: The quantal responses for somatic movement, and spontaneous and provoked lower oesophageal contractions (motility) were noted at the time of incision in 72 patients aged 40-65 yr, receiving varying concentrations of isoflurane. Probit analysis of the alveolar concentration of isoflurane required to prevent somatic movement revealed an MAC or EC50 (95% confidence limits) of 1.00 (0.82-1.17)% and EC95 of 2.16 (1.69-3.89)%. The EC50 of isoflurane to suppress spontaneous lower oesophageal contractions was 1.27 (1.12-1.43)%, and the EC95 2.13 (1.78-3.22)%. The EC50 for provoked lower oesophageal contractions was 1.31 (0.93-3.48)% and the EC95 was 6.18% (unable to compute confidence limits).
authors.affiliation: Sir Humphrey Davy Department of Anaesthesia, Bristol Royal Infirmary.
authors.forename: C
authors.initials: C
authors.lastname: Mather
authors.forename: S
authors.initials: S
authors.lastname: Raftery
authors.forename: C
authors.initials: C
authors.lastname: Prys-Roberts
mesh_terms: D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D004305:Dose-Response Relationship, Drug; D004947:Esophagus / Q000187:drug effects*; D005260:Female; D006801:Humans; D007530:Isoflurane / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000737:chemistry; D011897:Random Allocation
chemical_list: D007530:Isoflurane