Study on the metabolism of racemic prolintane and its optically pure enantiomers.
1. Asian and European volunteers were given racemic prolintane, and the metabolites in the 24 h urine were identified and quantified by g.l.c. mass spectroscopy using synthetic reference compounds. 2. R-(+)- and S-(-)-prolintane were synthesized from optically active phenylalanine. The metabolism of the enantiomers differs mainly in the quantitative amounts of metabolites.
Rücker
G
G
Pharmazeutisches Institut, Universität Bonn, Germany.
Neugebauer
M
M
Zhong
D
D
D000328:Adult; D044466:Asian People / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D011759:Pyrrolidines / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D044465:White People / Q000235:genetics
D011759:Pyrrolidines; C005598:prolintane