Chronic toxicity studies of sertaconazole after oral administration to rats and ferrets.
Six-month chronic oral toxicity studies of 7-chloro-3-[1-(2, 4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethoxy-methyl] benzo[b]thiophene (sertaconazole, FI-7045, CAS 99592-32-2) were carried out in rats and ferrets. The dose levels used were 50, 150 and 300 mg/kg in rats and 50, 150 and 250 mg/kg in ferrets. There was no mortality associated with the drug in either of the two species. The results obtained show that the toxic effects may be summarized as a smaller body weight increase in rats at 150 and 300 mg/kg and in male ferrets at 250 mg/kg. Food consumption decreased significantly in rats at 300 mg/kg, and was not proportional to the doses of 150 and 50 mg/kg. In serum biochemistry, increases in alkaline phosphatase in rats, ALT in male ferrets at 150 and 250 mg/kg and AST only at 250 mg/kg were observed. BUN increased at 150 and 250 mg/kg in ferrets.
Romero
A
A
Research Centre, Ferrer Group, Barcelona, Spain.
Villamayor
F
F
Grau
M T
MT
Sacristán
A
A
Ortiz
J A
JA
D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity*; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004798:Enzymes / Q000097:blood; D005260:Female; D005289:Ferrets; D007093:Imidazoles / Q000633:toxicity*; D008297:Male; D008321:Mammary Glands, Animal / Q000473:pathology; D010053:Ovary / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013876:Thiophenes / Q000633:toxicity*
D000935:Antifungal Agents; D004798:Enzymes; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole