A re-appraisal of a case of persistent global amnesia following right temporal lobectomy: a clinico-pathological study.
We report a reappraisal of patient NT who became severely amnesic after a right temporal lobectomy for intractable epilepsy (DINSDALE et al., Neuropsychologia 1, 287, 1964 [6]). Histological examination, albeit incomplete, indicated that there was no abnormality in the resected temporal lobe. At autopsy a sclerotic lesion of the unoperated left hippocampal formation was found. This case is therefore not an exception to the general rule that a severe and global amnesic state is only observed with bilateral lesions. Her performance on a wide range of memory tests is shown to be indistinguishable from patients with an amnesic syndrome due to Korsakoff's psychosis.
Warrington
E K
EK
National Hospital for Neurology and Neurosurgery, Institute of Neurology, London, U.K.
Duchen
L W
LW
D000368:Aged; D000647:Amnesia / Q000473:pathology / Q000503:physiopathology*; D001284:Atrophy; D004292:Dominance, Cerebral / Q000502:physiology; D004830:Epilepsy, Tonic-Clonic / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D011939:Mental Recall / Q000502:physiology; D009474:Neurons / Q000473:pathology / Q000502:physiology; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000473:pathology / Q000503:physiopathology*; D011612:Psychosurgery; D012153:Retention, Psychology / Q000502:physiology; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*