High-density-lipoprotein metabolism during a very-low-calorie diet.
We examined the changes in high-density-lipoprotein (HDL) metabolism in eight female obese patients undergoing a very-low-calorie diet (VLCD). In the first half of the study, HDL cholesterol (HDL-C), apolipoprotein A-I (apo A-I), and apo A-II showed a parallel decrease. Although lipoprotein lipase (LPL) and hepatic lipase (HTGL) did not change, lecithin: cholesterol acyltransferase (LCAT) decreased. In the latter half of the protocol, HDL-C and apo A-I increased whereas apo A-II decreased, resulting in increased apo A-I-A-II ratios. There was no change in LPL, HTGL, or LCAT. LCAT and apolipoprotein composition may be important in HDL-C changes after VLCD.
Shoji
T
T
Second Department of Internal Medicine, Osaka City University Medical School, Japan.
Nishizawa
Y
Y
Koyama
H
H
Hagiwara
S
S
Aratani
H
H
Sasao
K
K
Kishimoto
H
H
Tanishita
H
H
Morii
H
H
D000217:Acyltransferases / Q000097:blood; D000328:Adult; D016632:Apolipoprotein A-I / Q000378:metabolism; D016633:Apolipoprotein A-II / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism*; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D015431:Weight Loss / Q000502:physiology
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D008076:Cholesterol, HDL; D000217:Acyltransferases; D008049:Lipase