title: Measurement of resting energy expenditure in patients with chronic obstructive pulmonary disease in a clinical setting.
abstract: There is a growing tendency to estimate energy requirements by means of the assessment of resting energy expenditure (REE) by indirect calorimetry. In this study a computerized open-circuit ventilated hood system is described that was constructed for assessing REE in a clinical setting. Measurement error of the device, tested by ethanol combustion was +2% for VO2 and VCO2 and less than 1% for respiratory quotient. To assess the within-patient variability of REE measurements performed in a daily clinical routine, we studied the following aspects of the measurements in several groups of patients with chronic obstructive pulmonary disease: (1) reproducibility, (2) the influence of routine physical activities before the measurement, (3) measurement duration, and (4) difference between measurements using a ventilated hood or a mouthpiece. Reproducibility of measurements with a 2-month interval in 12 weight-stable patients was good (1415 +/- 128 and 1398 +/- 138 kcal/day). Variations due to limited activities and different measurement durations (between 10 and 30 minutes) were not significant. Variations between measurements with a mouthpiece and ventilated hood were larger in patients than in healthy control subjects, but for both groups no systematic difference was established. REE can be assessed reliably by short-term measurements with a ventilated hood in stable chronic obstructive pulmonary disease patients on an outpatient basis, provided a short rest is taken before the measurement.
authors.affiliation: Department of Pulmonary Diseases, University of Limburg, Maastricht, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Schols
authors.forename: P F
authors.initials: PF
authors.lastname: Schoffelen
authors.forename: H
authors.initials: H
authors.lastname: Ceulemans
authors.forename: E F
authors.initials: EF
authors.lastname: Wouters
authors.forename: W H
authors.initials: WH
authors.lastname: Saris
mesh_terms: D000368:Aged; D001481:Basal Metabolism; D002245:Carbon Dioxide / Q000032:analysis; D004734:Energy Metabolism; D000431:Ethanol; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis; D005082:Physical Exertion
chemical_list: D002245:Carbon Dioxide; D000431:Ethanol; D010100:Oxygen