Mifepristone (RU 486) treatment of meningiomas.
Meningiomas are common brain tumours which are generally benign, well circumscribed and slow growing. In a minority of patients complete surgical removal is not possible and re-growth of tumour tissue is a major clinical problem. Most meningiomas contain progesterone receptors. The anti-progestational drug mifepristone (RU 486) binds to these receptors. Ten patients were treated with 12 recurrent or primary "inoperable" meningiomas, all of whom had shown recent neuroradiological and/or ophthalmological evidence of tumour growth. They received 200 mg mifepristone daily for 12 months. Most patients initially had complaints of nausea, vomiting and/or tiredness. In four patients prednisone (7.5 mg/day) was given after which these side-effects subsided. CT scan analysis of tumour size, showed progression of growth of five meningiomas in four patients, stable disease in three patients with three tumours and regression of four tumours in three patients. A decrease in the complaints of headache and an improved general well being was observed in five patients. Two patients died during the treatment period from unrelated causes. Mifepristone treatment resulted in control of tumour growth (= stable disease) in six of 10 patients who had shown recent evidence of tumour growth. In three of these six patients consistent tumour shrinkage was observed.
Lamberts
S W
SW
Erasmus University, Rotterdam, The Netherlands.
Tanghe
H L
HL
Avezaat
C J
CJ
Braakman
R
R
Wijngaarde
R
R
Koper
J W
JW
de Jong
H
H
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000473:pathology; D008579:Meningioma / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D015735:Mifepristone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015995:Prevalence; D011374:Progesterone; D011980:Receptors, Progesterone / Q000096:biosynthesis; D012737:Sex Factors; D014057:Tomography, X-Ray Computed; D014407:Tumor Cells, Cultured
D014408:Biomarkers, Tumor; D011980:Receptors, Progesterone; D015735:Mifepristone; D011374:Progesterone