Proteinases in rheumatoid arthritis.
The role of proteinases in the extracellular breakdown of the connective tissue matrix during disease processes is outlined. Focussing on the matrix metalloproteinases, we present an overview of the mechanisms regulating their activity. Methods of assessing their role in disease processes is exemplified by new data on stromelysin activity in remodelling joint tissues in both model systems and human disease.
Murphy
G
G
Cell and Molecular Biology Department, Strangeways Research Laboratory, Cambridge, UK.
Hembry
R M
RM
D000818:Animals; D001168:Arthritis / Q000201:enzymology; D001172:Arthritis, Rheumatoid / Q000201:enzymology* / Q000473:pathology; D005109:Extracellular Matrix / Q000473:pathology; D006023:Glycoproteins / Q000502:physiology; D006801:Humans; D019278:Matrix Metalloproteinase 3; D008666:Metalloendopeptidases / Q000378:metabolism / Q000502:physiology*; D011509:Proteoglycans / Q000378:metabolism; D019714:Tissue Inhibitor of Metalloproteinases
D006023:Glycoproteins; D011509:Proteoglycans; D019714:Tissue Inhibitor of Metalloproteinases; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3