[The effects of prostaglandin E1 infusion on the viscosity and pH of gastric fluid during general anesthesia].
We studied the protective effect of prostaglandin E1 (PGE1)-induced hypotensive anesthesia on gastric mucosa in 30 elective surgical patients. Three groups, each composed of 10 patients, received PGE1, nitroglycerin or none during general anesthesia. Then we measured the viscosity and pH of gastric fluid continuously in each group. In the PGE1 group the viscosity and pH increased significantly and rapidly (P less than 0.05) as compared with the other groups. This suggests that PGE1 offers prophylactic effect against postoperative acute gastric mucosal lesion (AGML).
Mizogami
M
M
Department of Anesthesiology, Fukui Medical School.
Shine
S
S
Takakura
K
K
Sugiura
Y
Y
Harada
J
J
Goto
Y
Y
D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use*; D000768:Anesthesia, General; D005260:Female; D005750:Gastric Juice / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative; D014783:Viscosity / Q000187:drug effects
D000527:Alprostadil