[Ultracytochemical study of adenylate cyclase activity in Hela cell culture exposed to fluorine].
Electron microscopy has been used to study the adenylate cyclase activity in Hela cells after the incubation with 1.5 p. p. m. of fluoride for 5.30 and 60 minutes. It is established that the action of fluoride is accompanied by the increased enzyme activity in cell plasmalemma. Besides, the adenylate cyclase activity is revealed in the membrane of lipid droplets. In the mitotic cells a decrease of the enzyme activity in plasma membrane is observed parallel with its simultaneous increase in the metaphase chromosomes.
Strochkova
L S
LS
Barkhina
T G
TG
D000262:Adenylyl Cyclases / Q000187:drug effects* / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology; D005459:Fluorides / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007425:Intracellular Membranes / Q000201:enzymology; D008677:Metaphase / Q000187:drug effects; D008854:Microscopy, Electron; D008938:Mitosis / Q000187:drug effects
D000262:Adenylyl Cyclases; D005459:Fluorides
Ul'tratsitokhimicheskoe izuchenie aktivnosti adenilattsiklazy v kul'ture kletok Hela pri vozdeĭstvii ftora.