title: Multiple carcinoma in patients with psoriasis caused by psoralen-ultraviolet A therapy, natural killer cell insufficiency, or intensified sun exposure?
abstract: A case is presented of a patient with psoriasis in whom squamous cell carcinoma most likely occurred due to the interaction of various factors (psoralen-ultraviolet A therapy, sun exposure, and suppression of natural killer cell function). Therapy consisted of 1 mg/kg/daily of etretinate (Tegison), which resulted in clearing of psoriatic lesions in one month's time. New carcinomas did not develop and natural killer function improved.
authors.affiliation: Department of Dermatology, Latvian Medical Academy, Riga.
authors.forename: A Y
authors.initials: AY
authors.lastname: Rubins
authors.forename: D K
authors.initials: DK
authors.lastname: Branta
authors.forename: I V
authors.initials: IV
authors.lastname: Hartmane
authors.forename: A S
authors.initials: AS
authors.lastname: Rajevska
authors.forename: R A
authors.initials: RA
authors.lastname: Gutmane
authors.forename: Y M
authors.initials: YM
authors.lastname: Lielbriedis
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D005050:Etretinate / Q000627:therapeutic use; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D010778:Photochemotherapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects*
chemical_list: D005050:Etretinate