title: Adriamycin resistance is characterized by ultrastructural changes in human leukaemic K562 cells in vitro.
abstract: Ultrastructural changes associated with adriamycin (ADM) resistance have been investigated in the human K562 leukaemic cell line: sensitive K562 cells, a resistant subline cultured in the continuous presence of ADM and resistant cells without ADM Transmission electron microscopy (TEM) study revealed that K562-resistant cells displayed ultrastructural modifications of the cell surface, chromatin and nucleolus conformation. Alterations were not directly related to the presence of adriamycin as deprivated cells exhibited modificated characters through a slow progressive recovery phenomenon.
authors.affiliation: Laboratoire de Biologie et GIBSA, UFR Pharmacie, Reims, France.
authors.forename: H
authors.initials: H
authors.lastname: Bobichon
authors.forename: M G
authors.initials: MG
authors.lastname: Okiemi
authors.forename: C
authors.initials: C
authors.lastname: Broglio
authors.forename: D
authors.initials: D
authors.lastname: Ploton
authors.forename: J
authors.initials: J
authors.lastname: Dufer
mesh_terms: D000107:Acetylation; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D002843:Chromatin / Q000187:drug effects / Q000648:ultrastructure; D004317:Doxorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D013048:Specimen Handling; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure
chemical_list: D002843:Chromatin; D004317:Doxorubicin; D004492:Edetic Acid