title: Successful therapy for trilateral retinoblastoma.
abstract: Trilateral retinoblastoma, the intracranial malignancy associated with bilateral retinoblastoma, is an uncommon and clinically aggressive malignancy with a uniformly fatal outcome. Three children with newly diagnosed trilateral retinoblastoma were treated with systemic (cyclophosphamide and vincristine) and intrathecal (methotrexate, hydrocortisone, and cytarabine) chemotherapy, as well as craniospinal irradiation (one patient) in addition to therapy of the eye lesions. All three patients have had partial or complete response of the pineal tumors to chemotherapy, with no active disease eight or more years, 33 or more months, and 12 or more months, respectively, after diagnosis of the lesions.
authors.affiliation: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: S C
authors.initials: SC
authors.lastname: Nelson
authors.forename: H S
authors.initials: HS
authors.lastname: Friedman
authors.forename: W J
authors.initials: WJ
authors.lastname: Oakes
authors.forename: E C
authors.initials: EC
authors.lastname: Halperin
authors.forename: R
authors.initials: R
authors.lastname: Tien
authors.forename: G N
authors.initials: GN
authors.lastname: Fuller
authors.forename: B
authors.initials: B
authors.lastname: Hockenberger
authors.forename: M W
authors.initials: MW
authors.lastname: Scroggs
authors.forename: M
authors.initials: M
authors.lastname: Moncino
authors.forename: J
authors.initials: J
authors.lastname: Kurtzberg
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy*; D003287:Contrast Media; D005134:Eye Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D009942:Organometallic Compounds; D004369:Pentetic Acid; D010870:Pineal Gland; D012175:Retinoblastoma / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA