Leukemic evolution in three patients with myelodysplastic syndrome and unusual chromosome changes.
The authors describe three patients with myelodysplastic syndrome without a history of exposure to chemical agents and who showed many chromosome rearrangements not previously reported in this hematologic disorder, and a rapid outcome of the disease. The authors discuss the significance of the chromosome changes, suggesting, in agreement with others, that patients with complex rearrangements have a poor prognosis.
Palka
G
G
Istituto di Biologia e Genetica, Università di Chieti, Italy.
Calabrese
G
G
Stuppia
L
L
Guanciali Franchi
P
P
Antonucci
A
A
Spadano
A
A
Di Lorenzo
R
R
Torlontano
G
G
D000208:Acute Disease; D000368:Aged; D002869:Chromosome Aberrations; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000473:pathology; D011379:Prognosis