Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder?
Buspirone (BUSP) is a serotonergic (5-HT) agonist with activity at the 5-HT1A receptor. The BUSP induced prolactin (PRL) response was examined in 10 patients with a DSM IIIR diagnosis of obsessive-compulsive disorder (OCD). The results were compared with PRL responses to BUSP found in 10 age and sex matched healthy controls. The results suggest that the 5-HT1A receptor dysfunction may not be involved in the pathophysiology of OCD. The authors review the literature and consider the hypothesis that in OCD a complex interaction of other 5-HT receptor sub-types may be occurring, possibly with dysfunction primarily of the 5-HT2 receptors.
Lucey
J V
JV
Department of Psychiatry, Trinity College Medical School, St James's Hospital, Dublin, Eire.
Butcher
G
G
Clare
A W
AW
Dinan
T G
TG
D000328:Adult; D000368:Aged; D002065:Buspirone; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000097:blood / Q000503:physiopathology*; D011388:Prolactin / Q000097:blood / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology
D011985:Receptors, Serotonin; D011388:Prolactin; D002065:Buspirone