[Modulating action of intermediate molecular weight peptides on the course of experimental burn injury].
Preliminary injection of middle mass peptides (MMP) obtained from blood of intact dogs and dogs with burn injury aggravated the response of mice and rats to thermal injury. The mortality among mice with burns grew and the reaction of the lymphoid organs (thymus and spleen) of rats to the thermal burn was intensified. The aggravating action of MMP in mice correlated well with their damaging effect in experiments on human blood neutrophils. A MMP fraction possessing a protecting effect in burns in rats was isolated from the blood of intact dogs. The data obtained are discussed from the standpoint of the pathogenetic importance of MMP in burn disease.
Volchegorskiĭ
I A
IA
Val'dman
B M
BM
Skobeleva
N A
NA
Lifshits
R I
RI
Zurochka
A V
AV
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D008297:Male; D008970:Molecular Weight; D010455:Peptides / Q000009:adverse effects* / Q000097:blood
D010455:Peptides
Moduliruiushchee deĭstvie srednemolekuliarnykh peptidov na techenie ozhogovoĭ bolezni v éksperimente.