Tumor necrosis factor in the malnutrition (cachexia) of infection and cancer.
This review presents a history of tumor necrosis factor, considers the biology of this pleiotropic mediator, and summarizes the evidence that implicates it as a mediator of cachexia.
Tracey
K J
KJ
Division of Neurosurgery, Cornell University Medical Center, New York, New York.
Cerami
A
A
D000818:Animals; D002100:Cachexia / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007239:Infections / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology; D009748:Nutrition Disorders / Q000209:etiology / Q000503:physiopathology*; D011502:Protein-Energy Malnutrition / Q000209:etiology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects / Q000737:chemistry / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha