[The determination of pulmonary phospholipids in the gastric contents for an assessment of the respiratory distress syndrome].
Since hyaline membrane disease (HMD) is an important cause of mortality and morbidity in preterm newborns, we decided to evaluate the utility of pulmonary phospholipid (PP) determination in gastric aspirate for confirmatory diagnosis. For that purpose we studied 31 preterm and 30 term babies and compared the results between them and PP in gastric aspirate and amniotic fluid from their mothers. All the term newborns were normal, with mean weight of 3,221, and 39 weeks of gestational age; the results of phosphatidyl inositol (PI) and phosphatidyl glycerol (PG) were positive. The premature babies had a mean weight of 2,424 g and 35 weeks of gestational age. Thirteen had respiratory distress, 4 transient tachypnea and 9 HMD. In this group the babies with PI present and PG absent developed respiratory distress without HMD. The test had sensibility of 69% and specificity of 100%, and in patients without PG and PI the sensibility and specificity was 100%. We concluded that this test has enough sensibility and specificity for the confirmation of HMD in gastric aspirate when the PI and PG are not present.
Cano-González
R
R
División de Pediatría y Laboratorio de Líquidos Biológicos, Instituto Nacional de Perinatología, D.F., México.
Udaeta-Mora
E
E
Sosa-Ceja
R
R
Fernández-Carrocera
L
L
D002855:Chromatography, Thin Layer; D005766:Gastrointestinal Contents / Q000737:chemistry*; D006801:Humans; D006819:Hyaline Membrane Disease / Q000175:diagnosis; D007231:Infant, Newborn; D007234:Infant, Premature; D010715:Phosphatidylglycerols / Q000032:analysis; D010716:Phosphatidylinositols / Q000032:analysis; D011663:Pulmonary Surfactants / Q000032:analysis*; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D010715:Phosphatidylglycerols; D010716:Phosphatidylinositols; D011663:Pulmonary Surfactants
Determinación de los fosfolípidos pulmonares en contenido gástrico para evaluación del síndrome de dificultad respiratoria.