Biological carrier improves passive protection of mice against Pseudomonas aeruginosa infection.
In a model experiment, the use of specific hyperimmune globulins (SHG) alone failed to protect mice against infection with homologous and heterologous P. aeruginosa serotypes. However, the therapeutic potential of SHG dramatically improved after its conjugation with A1(OH)3, used as a biological carrier. The binding of SHG to this carrier proved to be the most effective and stable combination in the treatment of acute pseudomonad infections in mice.
Sourek
J
J
Institute of Hygiene and Epidemiology, Prague, Czechoslovakia.
Zelenková
L
L
Pokorný
J
J
D000536:Aluminum Hydroxide; D000818:Animals; D004337:Drug Carriers; D006384:Hemagglutination / Q000276:immunology; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D011552:Pseudomonas Infections / Q000276:immunology* / Q000517:prevention & control
D004337:Drug Carriers; D016756:Immunoglobulins, Intravenous; D000536:Aluminum Hydroxide