Effect of 3-morpholinosydnonimine (SIN-1), NG-nitro-L-arginine (NNA) and NG-monomethyl-L-arginine (NMMA) on isolated anaphylactic guinea-pig hearts.
In isolated perfused ovalbumin-sensitized guinea-pig hearts modulating effects of nitric oxide (NO) on cardiac function and eicosanoid release were investigated. While the NO-donor SIN-1 exhibited a protective effect during cardiac anaphylaxis, inhibition of NO biosynthesis by NNA or NMMA aggravated anaphylactic changes of cardiac functions. Exogenous and endogenous NO seems to functionally antagonize the effects of vasoconstrictor mediators released during the anaphylactic reaction. In addition, inhibition of cysteinyl-leukotriene (cys-LT) release could contribute to the protective effect of SIN-1 observed.
Pallapies
D
D
Department of Pharmacology and Toxicology, Ruhr-University of Bochum, Germany.
Thelen
K
K
Dembińska-Kieć
A
A
Simmet
T
T
Peskar
B A
BA
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D015777:Eicosanoids / Q000378:metabolism; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008981:Molsidomine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism; D019335:Nitroarginine; D010047:Ovalbumin / Q000276:immunology; D019323:omega-N-Methylarginine
D015777:Eicosanoids; D019335:Nitroarginine; D019323:omega-N-Methylarginine; C002385:linsidomine; D010047:Ovalbumin; D001120:Arginine; D008981:Molsidomine