title: Abnormalities of diastolic filling of the left ventricle associated with aging are less pronounced in exercise-trained individuals.
abstract: To determine whether exercise training has an effect on left ventricular diastolic dysfunction associated with the normal aging process, we studied a group of 20 normal healthy adult distance runners (mean miles currently run per week was 45 for an average of 15 years) and 20 normal healthy sedentary individuals (who currently walk less than 1 mile per day and are not involved in a regular exercise program) matched for age and systolic and diastolic blood pressure with the runners. Doppler echocardiographic indices of left ventricular diastolic filling were significantly different between the two groups. The exercise group when compared with the sedentary group had significantly decreased late diastolic peak filling velocity (0.51 +/- 0.11 m/sec versus 0.66 +/- 0.20 m/sec; p = 0.003), late diastolic velocity-time integral (5.2 +/- 1.5 cm versus 6.6 +/- 2.2 cm; p = 0.02), increased early-to-late peak filling velocity ratio (1.29 +/- 0.38 versus 0.96 +/- 0.24; p = 0.001), and early-to-late velocity-time integral ratio (2.08 +/- 0.51 versus 1.42 +/- 0.47; p less than 0.001). We conclude that the left ventricular diastolic dysfunction associated with "normal" aging is less pronounced in those persons who are exercise-trained.
authors.affiliation: Department of Medicine, LAC-USC Medical Center, University of Southern California School of Medicine 90033.
authors.forename: K A
authors.initials: KA
authors.lastname: Takemoto
authors.forename: L
authors.initials: L
authors.lastname: Bernstein
authors.forename: J F
authors.initials: JF
authors.lastname: Lopez
authors.forename: D
authors.initials: D
authors.lastname: Marshak
authors.forename: S H
authors.initials: SH
authors.lastname: Rahimtoola
authors.forename: P A
authors.initials: PA
authors.lastname: Chandraratna
mesh_terms: D000375:Aging / Q000502:physiology*; D015150:Echocardiography, Doppler; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D012420:Running; D016277:Ventricular Function, Left / Q000502:physiology*