beta-Carotene and alpha-tocopherol are synergistic antioxidants.
The possibility of a cooperative interaction between fat-soluble antioxidants is examined in a membrane model. A combination of beta-carotene and alpha-tocopherol results in an inhibition of lipid peroxidation significantly greater than the sum of the individual inhibitions. Our data provide the first evidence that beta-carotene can act synergistically with alpha-tocopherol as an effective radical-trapping antioxidant in membranes.
Palozza
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P
Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111-1837.
Krinsky
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NI
D000578:Amidines / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002338:Carotenoids / Q000494:pharmacology*; D004357:Drug Synergism; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014810:Vitamin E / Q000494:pharmacology*; D019207:beta Carotene
D000578:Amidines; D000975:Antioxidants; D019207:beta Carotene; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D002338:Carotenoids; D008315:Malondialdehyde; C046728:2,2'-azobis(2-amidinopropane)