title: Isocyanates and lung disease: experimental approaches to molecular mechanisms.
abstract: Isocyanates are reactive compounds that have commercial applications in the synthesis of a variety of products, including paints, coatings, elastomers, and foams. The correlation between isocyanates and a spectrum of respiratory disease has been established, primarily at the clinical level. The focus of this article is to bridge the gap of understanding from clinical symptoms to molecular reactivity, with emphasis on experimental approaches that serve to complement clinical and epidemiologic data.
authors.affiliation: Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213.
authors.forename: A L
authors.initials: AL
authors.lastname: Kennedy
authors.forename: W E
authors.initials: WE
authors.lastname: Brown
mesh_terms: D000818:Animals; D003485:Cyanates / Q000009:adverse effects / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure
chemical_list: D003485:Cyanates