Alterations in biodistribution of 11C-methamphetamine (MAP), 14C-MAP, and 123I-N-isopropyl-iodoamphetamine (IMP) in MAP- and cocaine-sensitized animals.
Alterations in brain distribution of 11C-MAP, 14C-MAP, and 123I-IMP in MAP- and cocaine-sensitized animals were examined to investigate the mechanism involved in increased dopaminergic transmission and behavioral sensitization. First, a significant increase in 11C-MAP radioactivity in the striatum and hypothalamus was found in the mice pretreated with MAP for 7 days. Secondly, in MAP-sensitized rats, marked increases in 14C-MAP radioactivity were found in the striatum and limbic forebrain, respectively (370% and 650%). These findings may propose a new hypothesis that subchronic MAP administration may result in a long-term change in the presynaptic cell membrane at the nerve terminal which may in turn cause an increase in both MAP and DA uptake accompanied by an increased release of DA at the synaptic cleft.
Numachi
Y
Y
Department of Psychiatry, Tohoku University School of Medicine, Sendai Miyagi, Japan.
Yoshida
S
S
Inosaka
T
T
Sato
M
M
Mizugaki
M
M
Kimura
K
K
Hishinuma
T
T
D000662:Amphetamines / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003042:Cocaine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000378:metabolism; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008032:Limbic System / Q000378:metabolism; D008297:Male; D008694:Methamphetamine / Q000493:pharmacokinetics*; D051379:Mice; D008815:Mice, Inbred Strains; D016548:Prosencephalon / Q000378:metabolism; D014018:Tissue Distribution
D000662:Amphetamines; D002250:Carbon Radioisotopes; D007457:Iodine Radioisotopes; D008694:Methamphetamine; D020367:Iofetamine; D003042:Cocaine