title: [Limited proteolysis of human albumin and immunoglobulin G by Legionella pneumophila metalloproteinase].
abstract: Metalloproteinase of Legionella pneumophila is the major extracellular proteinase of this bacterial species which splits human immunoglobulin G in the hinge region to form the (Fab')2 fragment. This fragment is relatively stable and undergoes further proteolysis at a slow rate. The c' fragment is unstable and is apparently split down to fragments CH2 and CH3. The metalloproteinase splits human serum albumin down to products having lower molecular masses. Another bacterial metalloproteinase, thermolysin, produces a similar effect, although at a slower rate.
authors.forename: S V
authors.initials: SV
authors.lastname: Gul'nik
authors.forename: G
authors.initials: G
authors.lastname: Feokharus
authors.forename: G I
authors.initials: GI
authors.lastname: Lavrenova
authors.forename: N V
authors.initials: NV
authors.lastname: Varchenko
authors.forename: V M
authors.initials: VM
authors.lastname: Stepanov
mesh_terms: D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D006868:Hydrolysis; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism*; D016952:Legionella pneumophila / Q000201:enzymology*; D008666:Metalloendopeptidases / Q000302:isolation & purification / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D013820:Thermolysin / Q000378:metabolism
chemical_list: D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D012709:Serum Albumin; D008666:Metalloendopeptidases; D013820:Thermolysin
vernacular_title: Ogranichennyĭ proteoliz al'bumina i immunoglobulina G cheloveka metalloproteinazoĭ Legionella pneumophila.