[Frequency of detection of hepatitis B markers in various chronic diseases in children].
Overall 995 children with different somatic chronic diseases were examined for viral hepatitis B markers demonstration using up-to-date highly sensitive methods (hemagglutination inhibition test, EIA). In the control group (children with acute intestinal infections), HBV-infection markers were discovered in 4.3%. Children with diabetes mellitus (13.1%), chronic renal diseases (18.9%), pulmonary diseases (32.8%), bronchial asthma (33.3%) and hemophilia (85.2%) are attributed to the group at greater risk for HBV infection. As a rule, the rate of HBV-infection markers demonstration in chronic somatic diseases was higher in considerable duration of the underlying illness. The overwhelming majority of the children examined had suffered subclinical forms of HBV-infection as shown by the disease history, whereupon they manifested antibodies against HBV antigens. HBs-antigenemia, that persisted for a long time (chronic HBV-infection) was demonstrable far less frequently. The authors provide evidence for the necessity of carrying out a broad-scale screening of HBV-infection markers in the indicated risk groups and vaccination against hepatitis B in children without HBsAG and without immunity to viral hepatitis B. The importance of measures aimed at preventing infections transmitted via blood is emphasized.
Kaganov
B S
BS
Grishina
M E
ME
Martynova
M I
MI
Rachinskiĭ
S V
SV
Turina
I E
IE
Gerasimov
A A
AA
Nisevich
N F
NF
Ust'kachkintsev
V A
VA
D015415:Biomarkers / Q000097:blood; D002353:Carrier State / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology; D004760:Enterocolitis / Q000150:complications* / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000032:analysis / Q000276:immunology; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000276:immunology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000276:immunology; D008297:Male; D012140:Respiratory Tract Diseases / Q000150:complications* / Q000276:immunology
D015415:Biomarkers; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens
Chastota vyiavleniia markerovvirusnogo gepatita B pri razlichnykh khronicheskikh zabolevaniiakh u deteĭ.