title: Elevated urinary excretion of orotic acid in sheep caused by intraruminal infusion of sodium propionate.
abstract: 1. The effect of sodium propionate on urinary excretion of orotic acid was investigated. 2. Solutions containing sodium propionate or NaCl, 750 mM/day each, were continuously infused into the rumen for 10 days. 3. During NaCl infusion, an urinary orotic acid excretion of 290 +/- 80 micrograms/day was noted. The intraruminal infusion of sodium propionate raised the concentration of propionic acid in the rumen fluid from 14.0 +/- 0.9 to 26.9 +/- 1.9 mM. 4. During this experimental period the excretion of orotic acid via urine significantly increased to 492 +/- 30 micrograms/day. Parameters of nitrogen balance were not altered by propionate. 5. It is suggested that the site of propionate action in intact sheep is in the pyrimidine synthesis pathway.
authors.affiliation: Department of Physiology, School of Veterinary Medicine, Hannover, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Bödeker
authors.forename: H
authors.initials: H
authors.lastname: Martens
mesh_terms: D000818:Animals; D007263:Infusions, Parenteral; D009584:Nitrogen / Q000378:metabolism; D009963:Orotic Acid / Q000652:urine*; D011422:Propionates / Q000008:administration & dosage / Q000494:pharmacology*; D012417:Rumen / Q000187:drug effects / Q000378:metabolism; D012756:Sheep; D012965:Sodium Chloride / Q000494:pharmacology; D014508:Urea / Q000097:blood
chemical_list: D011422:Propionates; D012965:Sodium Chloride; D009963:Orotic Acid; D014508:Urea; C514135:sodium propionate; C029658:propionic acid; D009584:Nitrogen