title: [Treatment of dilated cardiomyopathy in childhood].
abstract: Authors reviewed available information concerning etiology and pathophysiology of dilated cardiomyopathy. Diagnostic criteria and current poor results of conservative treatment are discussed. Between August 1984 and August 1991 67 children with various types of cardiomyopathy underwent heart and heart and lung transplantation at Harefield Hospital, U.K. Dilated cardiomyopathy was the indication for transplantation in 47 patients (mean age at operation was 6.5 years, range 0.3-4.8 years). Eighty-one percent actuarial survival at 4 years after operation represents reasonable progress in the treatment of this severe acquired disease. Currently, early transplantation is recommended in children with dilated cardiomyopathy and with low shortening fraction of left ventricle (below 0.13), without any improvement after 3 months of conservative treatment, will familial trait of dilated cardiomyopathy and/or with severe myocardial fibrosis.
authors.affiliation: Harefield Hospital, Middlesex a National Heart-Lung Institute, Londýn, Velká Británie.
authors.forename: R
authors.initials: R
authors.lastname: Radley-Smith
authors.forename: Z
authors.initials: Z
authors.lastname: Slavík
authors.forename: J
authors.initials: J
authors.lastname: Spatenka
authors.forename: M H
authors.initials: MH
authors.lastname: Yacoub
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000401:mortality / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016027:Heart Transplantation; D016041:Heart-Lung Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D015996:Survival Rate
vernacular_title: Moznosti lécby dilatacní kardiomyopatie v dĕtském vĕku.