title: Spike-train analysis reveals "overshoot" in developing rat prefrontal cortex function.
abstract: A multivariate analysis of spontaneous single neuron firing in the developing prefrontal cortex (PFC) of urethane anesthetized rats has been made using selected spike-train parameters. In particular, the development of modal interspike intervals closely paralleled the volumetric 'overshoot' reported earlier by us for rat PFC. Thus, the growth phase is characterized by progressively higher firing rates associated with longer modal intervals (i.e., a change from phasic to tonic firing, suggestive of increasingly effective inhibition). In contrast, the subsequent abrupt reduction in PFC volume is accompanied by the appearance of extremely short interspike intervals with no concomitant change in overall mean discharge rates ('burst' firing). This last development could be largely due to the 'pruning' of excessive excitatory synaptic contacts.
authors.affiliation: Netherlands Institute for Brain Research, Amsterdam.
authors.forename: M A
authors.initials: MA
authors.lastname: Corner
authors.forename: C G
authors.initials: CG
authors.lastname: Van Eden
authors.forename: A J
authors.initials: AJ
authors.lastname: De Beaufort
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000375:Aging / Q000502:physiology; D000758:Anesthesia; D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D005625:Frontal Lobe / Q000254:growth & development / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000502:physiology