title: Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region.
abstract: Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were localized to the region between nucleotides +37 and +159 relative to the transcription initiation site of the riboflavin operon. This region displays an unusual structure for regulatory sequences. The main part of it represents clusters of A/T and G/C-rich sequences that symmetrically blank a short inverted repeat.
authors.affiliation: Department of Molecular and Radiation Biophysics, Leningrad Nuclear Physics Institute of the Academy of Sciences of the USSR, Gatchina.
authors.forename: Y V
authors.initials: YV
authors.lastname: Kil
authors.forename: V N
authors.initials: VN
authors.lastname: Mironov
authors.lastname: Gorishin IYu
authors.forename: R A
authors.initials: RA
authors.lastname: Kreneva
authors.forename: D A
authors.initials: DA
authors.lastname: Perumov
mesh_terms: D001412:Bacillus subtilis / Q000201:enzymology / Q000235:genetics*; D001483:Base Sequence; D008969:Molecular Sequence Data; D016296:Mutagenesis / Q000235:genetics; D009690:Nucleic Acid Conformation; D009876:Operon / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D012256:Riboflavin / Q000096:biosynthesis / Q000235:genetics*; D012258:Riboflavin Synthase / Q000378:metabolism
chemical_list: D012258:Riboflavin Synthase; D012256:Riboflavin