Histamine: an early messenger in inflammatory and immune reactions.
The local concentration of histamine at sites of inflammation and immune responses is invariably high. Recent studies suggest that the biological relevance of this accumulation of histamine extends beyond its well-characterized role in mediating allergic reactions. In this article, András Falus and Katherine Merétey describe a possible function for histamine in cytokine-governed regulation of inflammatory and immune cascades.
Falus
A
A
Dept of Molecular Biology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
Merétey
K
K
D000210:Acute-Phase Reaction; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology*; D006632:Histamine / Q000502:physiology*; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D011968:Receptors, Histamine / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D015398:Signal Transduction
D016207:Cytokines; D011968:Receptors, Histamine; D006632:Histamine