Viral antigen presentation and MHC assembly.
Viruses and other intracellular pathogens represent a unique challenge to the vertebrate immune system. To deal with this problem of intracellular invasion the immune system has developed an elegant strategy to mark virally infected cells. This review discusses current issues relating to the cell biology of MHC molecule assembly and antigen presentation events from the standpoint of viruses and anti-viral immunity.
Braciale
T J
TJ
Beirne B. Carter Center for Immunology Research, University of Virginia, Health Sciences Center, Charlottesville 22908.
Braciale
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D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D000956:Antigens, Viral / Q000276:immunology* / Q000378:metabolism; D006183:H-2 Antigens / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism; D006649:Histocompatibility Antigens / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D008285:Major Histocompatibility Complex; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology / Q000378:metabolism
D000956:Antigens, Viral; D006183:H-2 Antigens; D006680:HLA Antigens; D006649:Histocompatibility Antigens; D014764:Viral Proteins