Pathophysiology of congenital diaphragmatic hernia. III: Exogenous surfactant therapy for the high-risk neonate with CDH.
Exogenous surfactant therapy (EST) in surfactant-deficient premature infants has been shown to improve lung compliance, decrease morbidity, and improve survival. Reports have demonstrated that newborns with congenital diaphragmatic hernia (CDH) have lung compliance, pressure-volume curves, and hyaline membrane formation resembling those changes seen in surfactant deficient premature newborns. We hypothesize that EST may also benefit infants with CDH. All high risk cases of prenatally diagnosed CDH at Children's Hospital of Buffalo from November 1988 to February 1991 were prospectively evaluated for EST. In those families who chose to participate, the surfactant preparation, Infasurf (100 mg/kg), was instilled into the newborn's lungs prior to the first breath. The remainder of the perinatal, neonatal, and surgical care was performed in a routine manner. Three high-risk prenatally diagnosed newborns with left CDH were treated with EST. All showed signs of decreased pulmonary compliance, but could still be adequately oxygenated and ventilated. Surgical correction was performed after stabilization and all required patch closures. Two of the three infants suffered no life-threatening episodes of pulmonary hypertension and all survived. These infants had many known indicators for poor outcome in CDH with an expected survival of less than 20%. We believe that EST in these neonates with CDH contributed to their survival with minimum morbidity. These results suggest that surfactant replacement for the high-risk neonate with CDH warrants further consideration and a randomized clinical trial is being planned.
Glick
P L
PL
Buffalo Institute of Fetal Therapy, Children's Hospital of Buffalo Perinatal Center, NY 14222.
Leach
C L
CL
Besner
G E
GE
Egan
E A
EA
Morin
F C
FC
Malanowska-Kantoch
A
A
Robinson
L K
LK
Brody
A
A
Lele
A S
AS
McDonnell
M
M
D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006548:Hernia, Diaphragmatic / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012307:Risk Factors
D011663:Pulmonary Surfactants