title: [Growth hormone therapy in STH deficiency with immunologic deficiency and chromosome fragility].
abstract: A 8 year old boy with short stature, low height velocity, mental retardation, cutaneous abnormalities, common variable immunodeficiency and increased chromosomal instability is described. In this patient growth hormone deficiency could be demonstrated by several stimulation tests. Growth hormone treatment increased growth rate from 4 cm/year before therapy to 7.8 cm in the first and 7.1 cm in the second year of treatment. Under therapy no effect on the immunological reactivity could be observed.
authors.affiliation: Gottfried von Preyer'sches Kinderspital, Wien.
authors.forename: P
authors.initials: P
authors.lastname: Blümel
authors.forename: M
authors.initials: M
authors.lastname: Eibl
mesh_terms: D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects / Q000235:genetics; D002648:Child; D002873:Chromosome Fragility; D004393:Dwarfism, Pituitary / Q000097:blood / Q000235:genetics*; D005500:Follow-Up Studies; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000235:genetics*; D007958:Leukocyte Count; D008297:Male
chemical_list: D013006:Growth Hormone
vernacular_title: Wachstumshormontherapie bei STH-Mangel mit Immundefizienz und Chromosomenbrüchigkeit.