Diabetes mellitus and exocrine pancreatic insufficiency in a girl with auto-immune haemolysis.
A 7-year-old girl developed diabetes mellitus and exocrine pancreatic insufficiency after 3.5 years of almost continuous treatment with azathioprine and/or prednisone for idiopathic auto-immune haemolytic anaemia. Although both drugs have been reported to preserve endogenous insulin secretion and to interrupt the diabetogenic process they may be responsible for diabetes and exocrine pancreatic insufficiency in our patient.
Sifianou
P
P
A' Paediatric Unit, Aghia Sophia Children's Hospital, Athens.
Tsoka
H
H
Kitra
V
V
Haidas
S
S
Pantelakis
S
S
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications* / Q000188:drug therapy; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000139:chemically induced*; D004357:Drug Synergism; D010188:Exocrine Pancreatic Insufficiency / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007223:Infant; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use
D001379:Azathioprine; D011241:Prednisone