Vasculopathic and cardiomyopathic changes induced by low-protein high-carbohydrate tapioca based diet in bonnet monkey. Vasculopathic and cardiomyopathic changes in induced malnutrition.
Mucoid vasculopathy is an entity characterized by a generalized mucopolysaccharidosis of blood vessels. It has been observed in patients from our Institute. Bonnet monkeys (Macaca radiata) were given low-protein normal-carbohydrate and low-protein high-carbohydrate tapioca based diets for experimental periods of 3 or 5 months. The latter diet is similar to that consumed by people from this part of India (Kerala) where mucoid vasculopathy is observed. Vascular lesions were seen in all test animals as a generalized mucopolysaccharidosis and as hyperplastic changes in intimal and medial smooth muscle cells. In 6/31 animals gross cardiac lesions were found. They consisted of biventricular hypertrophy and atrophy owning to myopathic changes and endocardial thickening. The cardiovascular lesions were enhanced in animals that received low-protein high-carbohydrate diet for a longer period. Our experiments established an etiologic role for diet, especially protein deficiency, in the induction of both vascular and cardiac changes.
Sandhyamani
S
S
Department of Pathology, Sree Chitra Tirunal Institute for Medical Studies & Tech, Trivandrum, India.
D000818:Animals; D009202:Cardiomyopathies / Q000209:etiology* / Q000473:pathology; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D008255:Macaca radiata; D008297:Male; D002365:Manihot; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009748:Nutrition Disorders / Q000150:complications*; D014652:Vascular Diseases / Q000209:etiology* / Q000473:pathology
D004040:Dietary Carbohydrates; D004044:Dietary Proteins