title: Enhancement of the oral absorption of cyclosporin in man.
abstract: 1. The oral absorption of cyclosporin from three new semi-solid oral formulations was compared with the standard soft gelatine preparation in twelve healthy male volunteers. One formulation was based on a solid micellar solution, while the other two, with different in vitro release properties, were based on a microemulsion principle. 2. The results showed that the solid micellar solution and the faster releasing microemulsion formulation increased the extent of absorption on average by 45.2 and 49.0%, respectively, compared with the reference soft gelatine capsule.
authors.affiliation: Department of Anesthesia and Research, University of Basel, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Drewe
authors.forename: R
authors.initials: R
authors.lastname: Meier
authors.forename: J
authors.initials: J
authors.lastname: Vonderscher
authors.forename: D
authors.initials: D
authors.lastname: Kiss
authors.forename: U
authors.initials: U
authors.lastname: Posanski
authors.forename: T
authors.initials: T
authors.lastname: Kissel
authors.forename: K
authors.initials: K
authors.lastname: Gyr
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002214:Capsules; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004655:Emulsions; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011897:Random Allocation
chemical_list: D002214:Capsules; D004655:Emulsions; D016572:Cyclosporine