title: Effect of somatotropin of mammalian cell origin in growth hormone deficiency.
abstract: Sixty-nine growth hormone-deficient patients were treated for 1 year with somatotropin (recombinant DNA-derived human growth hormone) produced in mouse cells. The growth velocity of the 50 patients (72%) in whom the effectiveness of this growth hormone could be evaluated increased from a mean (+/- SD) of 3.5 +/- 1.1 to 8.7 +/- 1.6. cm/y. An enhanced rate of weight gain was also observed. Bone age was not unduly accelerated. One of 66 patients developed antibodies to recombinant growth hormone, which did not affect the response to therapy. No patient developed antibodies to host cell proteins. An increased insulin response to a standard glucose load, without any change in glucose tolerance, was observed after 1 year of treatment. This authentic sequence human growth hormone preparation produced in mammalian cells is both effective and safe in the treatment of children with growth hormone deficiency.
authors.affiliation: Department of Pediatrics, UCLA.
authors.forename: S D
authors.initials: SD
authors.lastname: Frasier
authors.forename: C R
authors.initials: CR
authors.lastname: Rudlin
authors.forename: H J
authors.initials: HJ
authors.lastname: Zeisel
authors.forename: H H
authors.initials: HH
authors.lastname: Liu
authors.forename: P C
authors.initials: PC
authors.lastname: Long
authors.forename: B
authors.initials: B
authors.lastname: Senior
authors.forename: D N
authors.initials: DN
authors.lastname: Finegold
authors.forename: B B
authors.initials: BB
authors.lastname: Bercu
authors.forename: J F
authors.initials: JF
authors.lastname: Marks
authors.forename: G P
authors.initials: GP
authors.lastname: Redmond
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005947:Glucose / Q000378:metabolism; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D013006:Growth Hormone / Q000172:deficiency / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D013961:Thyroid Gland / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D007328:Insulin; D011994:Recombinant Proteins; D013006:Growth Hormone; D005947:Glucose