Cutaneous lymphadenoma: report of 2 cases.
Cutaneous lymphadenoma is a recently described tumor with a distinctive histological picture associating a basaloid epithelial proliferation and intraepithelial lymphocytes; it seems to represent a benign adnexal neoplasm of uncertain histogenesis. We documented 2 additional examples of cutaneous lymphadenoma with typical histological features; the contiguity of some tumor lobules with preexisting follicular structures was noted. In 1 case, a cutaneous osteoma was present below the tumor. On immunostainings, S-100 protein revealed numerous dendritic intraepithelial and stromal cells. The basaloid proliferation was positive for broad-spectrum keratin antibodies, but negative for KL1 antibody. In addition, several areas were positive for involucrin within tumor lobules. Our findings are consistent with a pilosebaceous origin of cutaneous lymphadenoma.
Masouyé
I
I
Clinique de dermatologie, Hôpital Cantonal Universitaire, Genève, Suisse.
D000328:Adult; D002280:Basal Cell Carcinoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000032:analysis / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D011498:Protein Precursors; C032253:involucrin