title: [Rapid spontaneous postpartum remission in a case of chronic inflammatory demyelinating polyradiculoneuropathy associated with pregnancy].
abstract: A 28-year-old woman developed numbness and weakness of the hands and arms when she was 8 months pregnant, and weakness worsened gradually. However, weakness started to spontaneously subside immediately after delivery and she felt almost recovered several hours later. But weakness and numbness recurred one week after delivery and she was admitted to our hospital. Neurological examination revealed moderate weakness and disturbance of the deep and cutaneous sensations in the upper and lower extremities, and marked decrease of the deep tendon reflexes. The upper extremities were more severely affected. Nerve conduction study showed marked decrease in the motor conduction velocities. Cerebrospinal fluid showed increase of protein without pleocytosis. Teased preparation of the biopsied sural nerve showed occasional internodal segments with thin myelination, indicating demyelination and remyelination. A diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy was made. Treatment with prednisolone markedly improved the weakness and hyporeflexia as well as the cerebrospinal fluid protein. Postpartum rapid remission may have been produced by rapid increase of endogenous steroid hormone in the blood by its massive excretion during delivery.
authors.affiliation: Department of Neurology, Mie University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Kawada
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Naitoh
authors.forename: Y
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: S
authors.initials: S
authors.lastname: Kuzuhara
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003711:Demyelinating Diseases / Q000503:physiopathology*; D005260:Female; D006801:Humans; D011129:Polyradiculoneuropathy / Q000503:physiopathology*; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D012075:Remission, Spontaneous