Analysis of sperm chromosome complements from a man heterozygous for a robertsonian translocation 45,XY,t(15q;22q).
Chromosome complements were studied in 118 sperm from a man heterozygous for a 15;22 Robertsonian translocation using the human sperm/hamster oocyte fusion technique. Alternate segregation occurred in most spreads (89.6%) and the proportion of normal (42.6%) and balanced complements (47%) was approximately equal. The frequency of sperm that were unbalanced with respect to the translocation was 10.4% and all categories of unbalanced sperm were observed (-15, -22, +15, +22). The frequency of chromosome abnormalities unrelated to the translocation was 7.6%. Since the frequencies of both numerical (3.4%) and structural abnormalities (3.4%) were within the normal range of control donors, there was no evidence for an interchromosomal effect. The frequencies of X-chromosome bearing (48%) and Y-chromosome bearing (52%) sperm were not significantly different from 50%. Data on this translocation were compared to the 4 other reports of cytogenetic analysis in sperm of Robertsonian translocation carriers.
Martin
R H
RH
Department of Pediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada.
Ko
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E
Hildebrand
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K
D000328:Adult; D002884:Chromosomes, Human, Pair 15; D002892:Chromosomes, Human, Pair 22; D006580:Genetic Carrier Screening / Q000379:methods*; D006801:Humans; D008297:Male; D008540:Meiosis / Q000235:genetics; D010375:Pedigree; D012730:Sex Chromosomes; D013094:Spermatozoa / Q000648:ultrastructure*; D014178:Translocation, Genetic / Q000235:genetics*