title: Correlation between serum immunoglobulin A concentrations and allergic manifestations in infants.
abstract: We studied the relationship of serum levels of IgA and IgE to allergic manifestations and otitis media in a cohort of 179 Icelandic children, aged 18 to 23 months. Only one of the infants had IgA deficiency (less than 50 micrograms/ml); all the others had IgA levels that were normal for their age. The children were divided into three groups according to their IgA levels (lowest 25%, intermediate 50%, highest 25%) and the clinical findings analyzed accordingly. The cumulative incidence of definite allergic manifestations was 37%. Asthma and otitis media were significantly more common among the infants with low normal IgA levels than among those with intermediate to high IgA levels. There was also a significant association between the severity of allergic manifestations and low IgA levels (p = 0.002). Children with detectable IgE (greater than or equal to 0.23 kilounit/L) had a higher incidence of atopic manifestations than did children in whom IgE was not detectable, but only a weak correlation was found between the occurrence and extent of allergic symptoms and increasing amounts of IgE beyond the 0.23 kilounit/L level. These findings suggest that atopic manifestations in infants may be more dependent on delayed maturation of IgA production than on overproduction of IgE.
authors.affiliation: Department of Immunology and Pediatrics, National University Hospital, Reykjavík, Iceland.
authors.forename: B R
authors.initials: BR
authors.lastname: Lúdvíksson
authors.forename: T H
authors.initials: TH
authors.lastname: Eiríksson
authors.forename: B
authors.initials: B
authors.lastname: Ardal
authors.forename: A
authors.initials: A
authors.lastname: Sigfússon
authors.forename: H
authors.initials: H
authors.lastname: Valdimarsson
mesh_terms: D001249:Asthma / Q000097:blood / Q000276:immunology; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000235:genetics / Q000276:immunology*; D007070:Immunoglobulin A / Q000032:analysis*; D007073:Immunoglobulin E / Q000032:analysis*; D015994:Incidence; D007223:Infant; D010033:Otitis Media / Q000097:blood / Q000276:immunology*; D012008:Recurrence; D012882:Skin Tests
chemical_list: D007070:Immunoglobulin A; D007073:Immunoglobulin E