Multiple carcinoma in patients with psoriasis caused by psoralen-ultraviolet A therapy, natural killer cell insufficiency, or intensified sun exposure?
A case is presented of a patient with psoriasis in whom squamous cell carcinoma most likely occurred due to the interaction of various factors (psoralen-ultraviolet A therapy, sun exposure, and suppression of natural killer cell function). Therapy consisted of 1 mg/kg/daily of etretinate (Tegison), which resulted in clearing of psoriatic lesions in one month's time. New carcinomas did not develop and natural killer function improved.
Rubins
A Y
AY
Department of Dermatology, Latvian Medical Academy, Riga.
Branta
D K
DK
Hartmane
I V
IV
Rajevska
A S
AS
Gutmane
R A
RA
Lielbriedis
Y M
YM
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology; D005050:Etretinate / Q000627:therapeutic use; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D010778:Photochemotherapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects*
D005050:Etretinate