title: Influence of prior information of drug toxicity on patient compliance.
abstract: Sixty patients with pulmonary tuberculosis, who had not received any chemotherapy in the past, were divided into two groups. All the patients were put on isoniazid, rifampicin and pyrazinamide for 8 weeks followed by isoniazid and rifampicin for another 18 weeks. Group A patients were informed of the likely occurrence of anorexia and/or vomiting but Group B patients were not. Routine and default retrieval home visits were given to ensure maximal drug compliance. Drug toxicity related early defaults were significantly less common in Group A patients (1 of 30) as compared to Group B (6 of 30).
authors.affiliation: Hospital for Chest and Tuberculosis, SMS Medical College, Jaipur.
authors.forename: P R
authors.initials: PR
authors.lastname: Gupta
authors.forename: M L
authors.initials: ML
authors.lastname: Gupta
authors.forename: S D
authors.initials: SD
authors.lastname: Purohit
authors.forename: T N
authors.initials: TN
authors.lastname: Sharma
authors.forename: M
authors.initials: M
authors.lastname: Bhatnagar
mesh_terms: D000328:Adult; D000855:Anorexia / Q000139:chemically induced; D000995:Antitubercular Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance / Q000523:psychology*; D010352:Patient Dropouts; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000995:Antitubercular Agents