Prenatal diagnosis of alpha-1-antitrypsin deficiency by PCR of linked polymorphisms: a study of 17 cases.
We describe our experiences of prenatal diagnosis of alpha-1-antitrypsin deficiency using closely linked polymorphisms detected by Southern blotting and the polymerase chain reaction. Prenatal diagnosis was carried out for 17 pregnancies from 15 couples.
Abbott
C M
CM
Department of Genetics and Biometry, University College London, U.K.
Lovegrove
J U
JU
Whitehouse
D B
DB
Hopkinson
D A
DA
Povey
S
S
D001483:Base Sequence; D015139:Blotting, Southern; D015193:Chorionic Villi Sampling; D005091:Exons; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011296:Prenatal Diagnosis; D019896:alpha 1-Antitrypsin Deficiency