[Pregnancy onset without corpus luteum function?].
Within five years, a patient had five abortions and one biochemical pregnancy with two different partners. After the fourth pregnancy, she underwent a heterologous immune stimulation. The karyotypes of all three partners were normal. On her first visit, a subclinical hypothyroidism was detected and substitution with 50 micrograms L-thyroxine was started. Before further endocrinological, virological, or anatomical investigation, the patient conceived spontaneously for the seventh time. Even though the beta-HCG-levels rose adequately and the sonographic development was according to time, serum-progesterone could not be detected before the eighth week of pregnancy and sufficient levels were found from the 15th week onwards. The patient received a hormonal substitution therapy with Gravibinon 250 mg i.m. twice a week up to the 15th week of gestation. She finally delivered a 3800 g healthy boy.
Ruttmann
E
E
Arzt für Frauenheilkunde, Hamburg.
Naether
O
O
D000026:Abortion, Habitual / Q000503:physiopathology*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D003338:Corpus Luteum / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000503:physiopathology*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011374:Progesterone / Q000097:blood
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol
Eintritt einer Gravidität ohne Corpus-luteum-Funktion?