The effect of propofol and thiopentone on pentylenetetrazol seizure threshold in the rat.
The protective effects of subanesthetic and anesthetic doses of propofol and thiopentone against pentylenetetrazol (PTZ)- induced seizures were studied in the rat. Intraperitoneal administration of propofol and thiopentone at doses producing comparable levels of sedation prior to intravenous infusion of PTZ, resulted in a marker and significant increase in PTZ seizure threshold. However, at all doses, the effects of propofol on PTZ convulsive threshold were more profound. These data suggest that propofol is an effective anticonvulsant and affords a greater degree of protection than thiopentone against PTZ-induced seizures in the rat.
Hasan
Z A
ZA
Department of Physiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid.
Hasan
M M
MM
al-Hader
A A
AA
Takrouri
M S
MS
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D005260:Female; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D015742:Propofol / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*; D013874:Thiopental / Q000627:therapeutic use*
D000927:Anticonvulsants; D013874:Thiopental; D010433:Pentylenetetrazole; D015742:Propofol