title: Timolol in lipospheres.
abstract: Lipospheres carrying timolol (1) were obtained from microemulsions. They had lecithin, palmitic and decanoic acids as the main constituents. The sizes were between 300 and 400 nm and the amount of 1 incorporated varied from 2.7 to 4.8% according to the microemulsion used. Compound 1 was present in the lipospheres mainly as ion pairs in order to increase its lipophilicity. The difference found in the incorporation was principally due to the different lipophilicity of the ion pairs of 1.
authors.affiliation: Dipartimento di Scienza e Tecnologia, Farmaco Università di Torino, Italy.
authors.forename: M R
authors.initials: MR
authors.lastname: Gasco
authors.forename: R
authors.initials: R
authors.lastname: Cavalli
authors.forename: M E
authors.initials: ME
authors.lastname: Carlotti
mesh_terms: D002626:Chemistry, Pharmaceutical; D003102:Colloids; D004058:Diffusion; D004655:Emulsions; D005612:Freeze Drying; D008055:Lipids; D008863:Microspheres; D010539:Permeability; D013999:Timolol / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D003102:Colloids; D004655:Emulsions; D008055:Lipids; D013999:Timolol