Single kidney function: early and late changes in urate transport after nephrectomy.
Renal urate transport was studied by means of pyrazinamide (PZA) and probenecid (PB): (a) before and at 2, 6, 24 weeks (24 patients), (b) 1 to 30 years after uninephrectomy in 27 and 12 patients with Ccr greater than 80 and 30 to 70 ml/min, respectively. Uninephrectomy was followed by important tubular urate transport modifications during at least two weeks, which lead to a marked uricosuria as indicated by significant increase in FEur (mean value +/- SD, 0.228 +/- 0.059 vs. 0.097 +/- 0.014 and 0.099 +/- 0.019 in normals and chronically diseased solitary kidneys). Reduced response to PZA and PB suggests a diminished reabsorptive capacity for urate mainly at the presecretory site which persisted after FENa normalization. Tubular compensations were presumably complete at six weeks, since pattern of urate transport returned to normal with an almost complete reabsorption of filtered urate load (99%) and a percentage of postsecretory reabsorption (80%) very close to those seen in normal subjects with a pair of kidneys. The adjustment in urate excretion in solitary kidneys was achieved by a significant increase of secreted urate as compared with 50% of pre-uninephrectomy values. Thus, increased urate secretion by the remaining intact organ is sufficient to maintain urate balance with a normal serum level.
Magoula
I
I
Second Clinic of Internal Medicine, Aristotelian University, Hippocration Hospital, Thessaloniki, Greece.
Tsapas
G
G
Mavromatidis
K
K
Katinios
A
A
D000328:Adult; D000368:Aged; D001693:Biological Transport, Active; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects*; D011339:Probenecid; D011718:Pyrazinamide; D012079:Renal Circulation; D013997:Time Factors; D014527:Uric Acid / Q000378:metabolism*
D014527:Uric Acid; D011718:Pyrazinamide; D011339:Probenecid