Corticosteroids after preterm premature rupture of membranes.
A review of all relevant randomized controlled trials provides strong evidence that corticosteroid therapy causes a significant reduction in respiratory distress syndrome (RDS) in preterm babies overall. This reduction in RDS is accompanied by a reduced incidence of neonatal death, intraventricular hemorrhages, and necrotizing enterocolitis. These benefits are also seen in cases of PROM. Corticosteroid therapy in PROM is associated with a trend toward an increase in neonatal infection.
Crowley
P
P
Department of Obstetrics and Gynaecology, University of Dublin, Trinity College, Coombe Lying-in Hospital, Ireland.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000209:etiology; D016032:Randomized Controlled Trials as Topic; D012127:Respiratory Distress Syndrome, Newborn / Q000196:embryology / Q000517:prevention & control*
D000305:Adrenal Cortex Hormones