title: Chromosomal analysis of pregnancy losses in patients undergoing assisted reproduction.
abstract: Chromosomal analysis was performed on products of conception from 18 patients having early pregnancy loss after assisted reproduction. Sonographic findings prior to obtaining tissue varied from gestational sacs consistent with a blighted ovum to fetal poles with cardiac activity. The mean age of the patients was 36.3 years. There were nine (50%) normal karyotypes, five (28%) autosomal trisomies, two cases of tetraploidy, one case of monosomy, and a case with two pericentric inversions. The results of this study suggest that patients undergoing assisted reproduction are not at an increased risk for chromosomal abnormalities.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284-7836.
authors.forename: L E
authors.initials: LE
authors.lastname: Shields
authors.forename: P C
authors.initials: PC
authors.lastname: Serafini
authors.forename: R S
authors.initials: RS
authors.lastname: Schenken
authors.forename: C M
authors.initials: CM
authors.lastname: Moore
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D002869:Chromosome Aberrations; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First