Influence of leukotriene D4 on arterial pressure and gastrointestinal electrical activity in the conscious piglet.
In 6 conscious weaned piglets with implanted electrodes in the corpus and antrum of the stomach, the duodenum, jejunum, ileum and caecum the influence of intravenous infusion of leukotriene (LT)D4, 0.1 and 1 microgram kgmin for 10 min, on mean arterial pressure and gastrointestinal electrical activity was examined. LTD4 induced a significant increase in arterial pressure. Gastrointestinal electrical activity, however, was little influenced, since only the antrum pylori revealed a transient decrease.
Wechsung
E
E
Laboratory of Veterinary Physiology, State University Centre of Antwerp, Belgium.
De Saedeleer
V
V
Houvenaghel
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003243:Consciousness; D004576:Electromyography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D010528:Peristalsis / Q000187:drug effects*; D013189:SRS-A / Q000494:pharmacology*; D013552:Swine / Q000502:physiology*
D013189:SRS-A