title: [Increasing the effectiveness of thiamine by its administration together with methionine and vitamin E].
abstract: The influence of methionine and vitamin E, compounds intensifying thiol metabolism, on thiamine-phosphate level and thiamine-dependent dehydrogenase activity was studied in the liver of rats with varying thiamine providing: in case of its alimentary deficiency, and intensified thiamine consumption due to rat feeding with high-carbohydrate food. Methionine administration to vitamin B1-deficient rats led to a significant rise in thiamine-phosphate content and normalized alpha-ketoacid dehydrogenase acidity and non-protein SH-group level. Combined administration of thiamine with methionine and vitamin E increased the level of parameters studied. Methionine and vitamin E administered with thiamine intensified the regulatory action of thiamine on pyruvate dehydrogenase activity in the animals fed high-carbohydrate ration.
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Parkhomenko
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Chernysh
authors.forename: Z S
authors.initials: ZS
authors.lastname: Protasova
authors.forename: G V
authors.initials: GV
authors.lastname: Donchenko
mesh_terms: D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D005527:Food, Fortified; D007658:Ketone Oxidoreductases / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000008:administration & dosage* / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013831:Thiamine / Q000008:administration & dosage* / Q000378:metabolism; D013832:Thiamine Deficiency / Q000188:drug therapy* / Q000378:metabolism; D014810:Vitamin E / Q000008:administration & dosage* / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D011768:Pyruvate Dehydrogenase Complex; D013438:Sulfhydryl Compounds; D014810:Vitamin E; D008715:Methionine; D007658:Ketone Oxidoreductases; D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D013831:Thiamine
vernacular_title: Povyshenie éffektivnosti ispol'zovaniia tiamina pri vvedenii ego v organizm sovmestno s metioninom i vitaminom E.