title: A double-blind study of ibuprofen versus placebo in the treatment of acute migraine attacks.
abstract: The efficacy of ibuprofen, a non-steroidal anti-inflammatory drug, was assessed in the acute treatment of migraine. Twenty-five patients completed a double-blind placebo-controlled multicrossover trial. The initial dose of ibuprofen was 1200 mg. Six migraine attacks were randomly treated in each patient, three with ibuprofen and three with placebo. The results indicated a statistically significant reduction in the duration of the migraine attacks and also a statistically significant reduction in the severity of headache and nausea in the ibuprofen-treated attacks. The use of additional medication was significantly reduced in the ibuprofen-treated attacks (25.6% vs 57.5%). No serious side effects were reported. Ibuprofen is valuable in the treatment of acute migraine attacks.
authors.affiliation: Department of Neurology, Vestfold Central Hospital, Tønsberg, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Kloster
authors.forename: K
authors.initials: K
authors.lastname: Nestvold
authors.forename: S T
authors.initials: ST
authors.lastname: Vilming
mesh_terms: D000208:Acute Disease; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D007052:Ibuprofen