Intranasal administration of a beta adrenergic amine: an alternative to metered-dose inhalers.
In anesthetized, artificially ventilated guinea pigs, intranasal and intravenous administration of albuterol produced the same maximum degree of protection against bronchoconstriction induced by bilateral electrical stimulation of the cervical vagal nerves. Intranasal albuterol showed a slower onset of action than intravenous albuterol and exhibited equivalent cardiovascular side effects for the same level of bronchoprotection. Accordingly, intranasal albuterol may represent an alternative to metered-dose inhalation for prophylaxis and treatment of bronchoconstriction in humans.
Hussain
A A
AA
Albert B. Chandler Medical Center, Medicinal Chemistry and Pharmaceutics Division, University of Kentucky College of Pharmacy, Lexington.
Diamond
L
L
Thompson
D
D
Lantta
J
J
Dittert
L W
LW
D000280:Administration, Inhalation; D000281:Administration, Intranasal; D000420:Albuterol / Q000008:administration & dosage*; D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D008297:Male
D000420:Albuterol