Similar inhibition of mitochondrial respiration by 1-methyl-4-phenyl-pyridinium (MPP+) and by a unique N-methylated beta-carboline analogue, 2,9-dimethyl-norharman (2,9Me2NH).
Fields
J Z
JZ
Department of Pharmacology, Loyola University, Stritch School of Medicine, Maywood, Illinois 60153.
Albores
R
R
Neafsey
E J
EJ
Collins
M A
MA
D015655:1-Methyl-4-phenylpyridinium / Q000494:pharmacology*; D000818:Animals; D002243:Carbolines / Q000494:pharmacology; D006247:Harmine; D007700:Kinetics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D012402:Rotenone / Q000494:pharmacology; D013386:Succinates / Q000378:metabolism
D002243:Carbolines; D013386:Succinates; D012402:Rotenone; C005986:2,9-dimethyl-beta-carbolinium; D006247:Harmine; D015655:1-Methyl-4-phenylpyridinium