title: Levamisole plus 5-fluorouracil inhibits the growth of human colorectal xenografts in nude mice.
abstract: Fragments of human colorectal adenocarcinomas were inserted under the renal capsule of nude mice. The growth of these tumour grafts was significantly inhibited by the combination of 5-fluorouracil (5-FU) and levamisole. An alternating regimen of levamisole 2.5 mg/kg and 5-FU 20 mg/kg decreased the size of tumour implants by 33-59% and/or increased the number of macroscopically disappeared fragments in the combined group compared with ineffective monotherapy with saline, levamisole or 5-FU. This model could be valuable for investigating the mechanism of action of levamisole and to evaluate the effects of this adjuvant therapy in other oncological settings.
authors.affiliation: Janssen Research Foundation, Beerse.
authors.forename: R
authors.initials: R
authors.lastname: Van Ginckel
authors.forename: W
authors.initials: W
authors.lastname: Distelmans
authors.forename: M
authors.initials: M
authors.lastname: De Brabander
authors.forename: M
authors.initials: M
authors.lastname: Callens
authors.forename: B
authors.initials: B
authors.lastname: Janssens
authors.forename: E
authors.initials: E
authors.lastname: Jagers
authors.forename: L
authors.initials: L
authors.lastname: Wouters
authors.forename: R
authors.initials: R
authors.lastname: De Coster
authors.forename: P A
authors.initials: PA
authors.lastname: Janssen
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007978:Levamisole / Q000008:administration & dosage; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012004:Rectal Neoplasms / Q000188:drug therapy*; D014183:Transplantation, Heterologous
chemical_list: D007978:Levamisole; D005472:Fluorouracil