Tumor necrosis factor-alpha inhibitory activity in urine of Kawasaki disease.
Recently it has been reported that naturally occurring inhibitors of tumor necrosis factor alpha (TNF-alpha) were demonstrated in urine of some acute febrile patients. We investigated whether TNF-alpha inhibitory activity in urine increases during acute Kawasaki disease (KD). TNF-alpha inhibitory activities in urine were measured by a cytotoxicity assay on the TNF-susceptible cell line L929. KD patients had increased TNF-alpha inhibitory activities in urine during the acute stage and returned to a normal range during the convalescent stage. Our results suggest that the TNF-alpha inhibitor in urine is part of the regulatory system of TNF-alpha, which might be responsible for vascular injury during acute KD.
Matsubara
T
T
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Furukawa
S
S
Suzuki
J
J
Yone
K
K
Yabuta
K
K
D002675:Child, Preschool; D003327:Coronary Disease / Q000652:urine; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000652:urine*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000652:urine*
D014409:Tumor Necrosis Factor-alpha