title: [Effect of intraventricular injection of 6-hydroxydopamine on the initiation of hibernation in ground squirrels].
abstract: The effect of forced depletion of brain norepinephrine (NE) on the onset of hibernation was observed in the ground squirrel (Citellus dauricus) by intraventricular injection of 6-hydroxydopamine (6-OHDA). The results showed: (1) Intraventricular injection of 100-200 micrograms 6-OHDA, which depleted 50-60% NE, markedly facilitated the onset of hibernation, i.e. the average induction period for hibernation in the treated animals was significantly shorter than that of the natural hibernating animals. (2) The average total torpor time in the treated animals was longer than that of natural hibernating animals. (3) All hibernating animals treated with 6-OHDA were able to wake up from deep hibernation spontaneously and undergo normal hibernation bouts. The results indicate the decrease of NE system activity in brain is one important factor in triggering the onset of hibernation.
authors.affiliation: Department of Biology, Peking University, Beijing.
authors.forename: Y P
authors.initials: YP
authors.lastname: Cai
authors.forename: Q H
authors.initials: QH
authors.lastname: Huang
authors.forename: H Q
authors.initials: HQ
authors.lastname: Zhao
authors.forename: C L
authors.initials: CL
authors.lastname: Zhang
authors.forename: H
authors.initials: H
authors.lastname: Wang
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D005260:Female; D006605:Hibernation / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology*; D012589:Sciuridae / Q000502:physiology*
chemical_list: D016627:Oxidopamine; D009638:Norepinephrine