title: Drug therapy of ventricular tachycardia: a cost comparison of randomized noninvasive and invasive approaches.
abstract: OBJECTIVE
  Economic evaluation of noninvasive (suppression of ventricular arrhythmias detected by ambulatory monitoring) and invasive (suppression of arrhythmias induced by programmed stimulation) approaches to antiarrhythmic drug selection for ventricular tachyarrhythmias.
  
  
  METHODS
  Randomized clinical trial/tertiary-care hospital.
  
  
  METHODS
  Of 124 consecutive patients referred for treatment of symptomatic ventricular tachyarrhythmias, 57 consenting patients were eligible to have drug therapy selected by either noninvasive or invasive approaches.
  
  
  METHODS
  Costs of initial and follow-up (26 +/- 15 months) admissions for the two groups were compared. This economic evaluation also considered relative efficacies of the approaches using the primary outcome variable of symptomatic, sustained ventricular tachyarrhythmia recurrence (including sudden death).
  
  
  RESULTS
  Initial hospitalization for therapy selection was less costly by the noninvasive approach ($6,869 +/- 4,019) than by the invasive approach ($13,164 +/- 6,740) (P less than 0.001). However, the noninvasive approach generated higher follow-up hospital costs ($9,204 +/- 9,217) than the invasive approach ($3,784 +/- 4,944) (P = 0.01). Thus, total hospital costs of the noninvasive ($16,073 +/- 9,423) and invasive approaches ($16,949 +/- 7,174) were equivalent. The two-year actuarial probability of a recurrent, sustained, symptomatic ventricular tachyarrhythmia was greater in noninvasive (0.50 +/- 0.10) than in invasive (0.20 +/- 0.08) approach patients (P = 0.02).
  
  
  CONCLUSIONS
  The lower initial hospital costs of the noninvasive approach are offset by greater follow-up costs. Within two years the costs of the two approaches are equivalent. Thus, greater antiarrhythmic efficacy can be achieved by the invasive approach to drug selection without increasing total hospital costs.
authors.affiliation: Department of Medicine, Foothills Medical Centre, Calgary, Alberta.
authors.forename: L B
authors.initials: LB
authors.lastname: Mitchell
authors.forename: H J
authors.initials: HJ
authors.lastname: Duff
authors.forename: C E
authors.initials: CE
authors.lastname: Miller
authors.forename: H P
authors.initials: HP
authors.lastname: Eliasoph
authors.forename: D G
authors.initials: DG
authors.lastname: Wyse
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000191:economics / Q000627:therapeutic use*; D002170:Canada; D016527:Drug Costs; D004562:Electrocardiography; D005080:Exercise Test; D005500:Follow-Up Studies; D006352:Heart Ventricles; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D013610:Tachycardia / Q000188:drug therapy* / Q000191:economics; D014693:Ventricular Fibrillation / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents