Diffuse leptomeningeal involvement by a ganglioglioma in a child. Case report.
Gangliogliomas are tumors composed of neuronal and glial elements that typically grow slowly by expansion only. This report describes a 20-month-old girl with a ganglioglioma that extensively involved the subarachnoid space; microscopic foci of tumor were found in the brain and spinal cord. Despite chemotherapy and radiation therapy, the child died 5 months after diagnosis. Molecular genetic analysis showed loss of chromosome 17p DNA sequences in the tumor tissue.
Wacker
M R
MR
Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
Cogen
P H
PH
Etzell
J E
JE
Daneshvar
L
L
Davis
R L
RL
Prados
M D
MD
D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D013346:Subarachnoid Space / Q000473:pathology*
D004273:DNA, Neoplasm