Adherence of human newborn infants' monocytes to matrix-bound fibronectin.
The localization of monocytes to sites of inflammation is mediated by interactions with extracellular matrix components including fibronectin, a nonimmune opsonin with binding sites for collagen, fibrin, heparin, and cell surfaces. This study demonstrates that newborn infants' monocytes bind to both gelatin (i.e., denatured collagen) and matrix-bound fibronectin to a degree comparable to that of adult-derived cells.
Roth
P
P
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
Polin
R A
RA
D000328:Adult; D002448:Cell Adhesion; D005312:Fetal Blood; D005353:Fibronectins / Q000378:metabolism*; D005780:Gelatin / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn / Q000097:blood*; D009000:Monocytes / Q000378:metabolism* / Q000502:physiology; D011485:Protein Binding / Q000502:physiology
D005353:Fibronectins; D005780:Gelatin