Synthesis and anthelmintic activity of carbamates derived from imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b]thiazole.
The anthelmintic activity of 25 compounds, most of them carbamates, was determined. The in vitro results are interesting and show that an aromatic azapentalene can replace the benzimidazole ring without loss of its biological properties. The in vivo results, however, show that the compounds are devoid of practical interest.
Marin
A
A
Departamento de Quimica Organica, Facultad de Farmacia, Universidad de Barcelona, Spain.
Valls
N
N
Berenguer
F J
FJ
Alonso
M T
MT
Ramon Martinez
A
A
Mercedes Martinez
M
M
Elguero
J
J
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000969:Antinematodal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002107:Caenorhabditis / Q000187:drug effects; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D051379:Mice; D009348:Nematoda / Q000187:drug effects; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use
D000871:Anthelmintics; D000969:Antinematodal Agents; D002219:Carbamates; D007093:Imidazoles; D013830:Thiadiazoles; D013844:Thiazoles