In vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains.
E1040 showed the most potent activity (MIC for 90% of strains, 6.25 micrograms/ml) among beta-lactams tested against 70 strains of imipenem-resistant Pseudomonas aeruginosa. Two strains showed high-level resistance to E1040; one strain produced a type II oxyiminocephalosporin-hydrolyzing beta-lactamase (group 3), and the other produced an enzyme similar to a type II penicillinase (OXA-1). Both beta-lactamases contributed to resistance to E1040.
Watanabe
M
M
Episome Institute, Seta-gun, Japan.
Inoue
E
E
Katsu
K
K
Iyobe
S
S
Mitsuhashi
S
S
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D015378:Imipenem / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D015378:Imipenem; C056494:cefclidin