title: Stereoselective effect of phenprocoumon enantiomers on the binding of benzodiazepines to human serum albumin.
abstract: The effect of phenprocoumon enantiomers on the stereoselective binding of 3-substituted 1,4-benzodiazepines to human serum albumin (HSA) was studied by chromatography on HSA-Sepharose column. (S)-Phenprocoumon exerts stereoselective allosteric interaction on the binding of benzodiazepines. The structural requirements of enhanced stereoselectivities are similar to those found previously with (S)-warfarin.
authors.affiliation: Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
authors.forename: I
authors.initials: I
authors.lastname: Fitos
authors.forename: M
authors.initials: M
authors.lastname: Simonyi
mesh_terms: D001569:Benzodiazepines / Q000378:metabolism*; D002845:Chromatography; D006801:Humans; D007700:Kinetics; D010644:Phenprocoumon / Q000494:pharmacology*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D013237:Stereoisomerism; D014859:Warfarin / Q000494:pharmacology
chemical_list: D012709:Serum Albumin; D001569:Benzodiazepines; D014859:Warfarin; D010644:Phenprocoumon