title: [Osteosarcomas of the mandible].
abstract: On the base of 3 cases of mandibular osteosarcoma, the current role of surgery is specified. The most often used procedure is Rosen's protocol, which includes: preoperative chemotherapy, radical surgery with reconstruction, and postoperative chemotherapy. The key element is the pathological study of the surgical specimen. This will determine the response of the tumor to preoperative chemotherapy and, by comparing the histology of the initial biopsy specimen to that of the surgical specimen, will be used as a basis to select the postoperative chemotherapy. For this type of tumor, chemotherapy has completely substituted for radiation therapy, which is no longer used in the initial treatment. Prophylactic lung radiation therapy has also been given up due to the risks of pulmonary fibrosis entailed by the effective doses. Surgery still has a role of choice in the therapeutic schedule, even if it cannot be contemplated as the sole treatment. Considering the usually young age of the patients, we currently think that reconstruction must be immediate and must resort to all the techniques likely to produce the best possible functional and morphological result.
authors.affiliation: Service de Stomatologie, Hôpital Central, Nancy.
authors.forename: P
authors.initials: P
authors.lastname: Sibille
authors.forename: G
authors.initials: G
authors.lastname: Dinh Doan
authors.forename: C
authors.initials: C
authors.lastname: Rodier
authors.forename: J F
authors.initials: JF
authors.lastname: Chassagne
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008334:Mandible / Q000601:surgery; D008339:Mandibular Neoplasms / Q000601:surgery*; D012516:Osteosarcoma / Q000601:surgery*; D011182:Postoperative Care; D011300:Preoperative Care
vernacular_title: Les ostéosarcomes de la mandibule.