Frequency of D8/17 B lymphocyte alloantigen in north Indian patients with rheumatic heart disease.
Ninety patients with rheumatic heart disease and 50 age- and sex-matched healthy human volunteers representing a North Indian population were typed for the B cell alloantigen D8/17 using a monoclonal antibody and a single step immunofluorescence technique. This alloantigen was expressed in 66.44% patients with RHD as compared with 14% of the normal population. A high relative risk (RR = 11.13) indicated a strong association of D8/17 B cell alloantigen with rheumatic heart disease. Increase in the frequency of the marker was observed with increasing age up to the fifth decade (40-49 years) in these patients. However, the frequency of this alloantigen, in the present study, in North Indian patients with rheumatic heart disease is lower than that reported in the American population.
Ganguly
N K
NK
Department of Cardiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Anand
I S
IS
Koicha
M
M
Jindal
S
S
Wahi
P L
PL
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis* / Q000235:genetics; D002648:Child; D005260:Female; D005455:Fluorescent Antibody Technique; D005787:Gene Frequency; D006801:Humans; D007194:India; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008946:Mitral Valve Stenosis / Q000235:genetics / Q000276:immunology; D012214:Rheumatic Heart Disease / Q000235:genetics / Q000276:immunology*; D012737:Sex Factors
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D007519:Isoantigens