Enhancement of the oral absorption of cyclosporin in man.
1. The oral absorption of cyclosporin from three new semi-solid oral formulations was compared with the standard soft gelatine preparation in twelve healthy male volunteers. One formulation was based on a solid micellar solution, while the other two, with different in vitro release properties, were based on a microemulsion principle. 2. The results showed that the solid micellar solution and the faster releasing microemulsion formulation increased the extent of absorption on average by 45.2 and 49.0%, respectively, compared with the reference soft gelatine capsule.
Drewe
J
J
Department of Anesthesia and Research, University of Basel, Switzerland.
Meier
R
R
Vonderscher
J
J
Kiss
D
D
Posanski
U
U
Kissel
T
T
Gyr
K
K
D000284:Administration, Oral; D000328:Adult; D002214:Capsules; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004655:Emulsions; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D011897:Random Allocation
D002214:Capsules; D004655:Emulsions; D016572:Cyclosporine