Polymeric sorbents for bile acids. I: Comparison between cholestyramine and colestipol.
Isotherms for the sorption of bile acids at 20 degrees C, in tris(hydroxymethyl)aminomethane.HCl(tris) and KH2PO4-NaOH (phosphate) buffers (pH 7.4), indicate that the binding by cholestyramine and colestipol is mainly through ionic linkages, although hydrophobic interactions are also of importance. Cholestyramine has a higher sorption capacity for bile acids, in both buffers, than colestipol. The chloride form of cholestyramine has a higher capacity for cholate in tris buffer than the iodide form. Increased ionic strength of the medium leads to decreased amounts of sorption.
Zhu
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Department of Chemistry, McGill University, Montreal, PQ, Canada.
Brown
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St-Pierre
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D000042:Absorption; D001647:Bile Acids and Salts / Q000737:chemistry*; D002021:Buffers; D002792:Cholestyramine Resin / Q000737:chemistry*; D019826:Cholic Acid; D002793:Cholic Acids / Q000737:chemistry; D003084:Colestipol / Q000737:chemistry*; D008433:Mathematics; D013696:Temperature
D001647:Bile Acids and Salts; D002021:Buffers; D002793:Cholic Acids; D002792:Cholestyramine Resin; D019826:Cholic Acid; D003084:Colestipol