Pathogenesis of Parkinson's disease.
The importance of genetic aspects, ageing, environmental factors, head trauma, defective mitochondrial respiration, altered iron metabolism, oxidative stress and glutamatergic overactivity of the basal ganglia in the pathogenesis of Parkinson's disease (PD) are considered in this review.
Riederer
P
P
Department of Clinical Neurochemistry, University Hospital for Nervous Diseases, University of Würzburg, Germany.
Lange
K W
KW
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000368:Aged; D000818:Animals; D006801:Humans; D010300:Parkinson Disease / Q000209:etiology* / Q000503:physiopathology; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology; D011954:Receptors, Dopamine / Q000502:physiology; D012307:Risk Factors; D013378:Substantia Nigra / Q000503:physiopathology
D011954:Receptors, Dopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine