Visual acuities and scotomas after one week levodopa administration in human amblyopia.
The authors previously showed that a single dose of levodopa improves the contrast sensitivity and decreases the size of fixation point scotomas in amblyopic patients. In the present study, they investigated the effect of levodopa after 1 wk of daily administration using a cross-over, double masked design. The decrease of fixation point scotomas was confirmed with automatic static perimetry. An improvement of visual acuity occurred in 70% of the patients after 1 wk of levodopa administration compared to only 22% in the authors' previous study using one single dose. The improvements in visual acuities and visual fields persisted even after the levodopa administration was completed.
Gottlob
I
I
Foerderer Eye Movement Center for Children, Wills Eye Hospital, Philadelphia, Pennsylvania 19107.
Charlier
J
J
Reinecke
R D
RD
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000550:Amblyopia / Q000188:drug therapy*; D002648:Child; D015350:Contrast Sensitivity / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012607:Scotoma / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects*; D014794:Visual Fields / Q000187:drug effects
D010919:Placebos; D007980:Levodopa