title: High-density-lipoprotein metabolism during a very-low-calorie diet.
abstract: We examined the changes in high-density-lipoprotein (HDL) metabolism in eight female obese patients undergoing a very-low-calorie diet (VLCD). In the first half of the study, HDL cholesterol (HDL-C), apolipoprotein A-I (apo A-I), and apo A-II showed a parallel decrease. Although lipoprotein lipase (LPL) and hepatic lipase (HTGL) did not change, lecithin: cholesterol acyltransferase (LCAT) decreased. In the latter half of the protocol, HDL-C and apo A-I increased whereas apo A-II decreased, resulting in increased apo A-I-A-II ratios. There was no change in LPL, HTGL, or LCAT. LCAT and apolipoprotein composition may be important in HDL-C changes after VLCD.
authors.affiliation: Second Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shoji
authors.forename: Y
authors.initials: Y
authors.lastname: Nishizawa
authors.forename: H
authors.initials: H
authors.lastname: Koyama
authors.forename: S
authors.initials: S
authors.lastname: Hagiwara
authors.forename: H
authors.initials: H
authors.lastname: Aratani
authors.forename: K
authors.initials: K
authors.lastname: Sasao
authors.forename: H
authors.initials: H
authors.lastname: Kishimoto
authors.forename: H
authors.initials: H
authors.lastname: Tanishita
authors.forename: H
authors.initials: H
authors.lastname: Morii
mesh_terms: D000217:Acyltransferases / Q000097:blood; D000328:Adult; D016632:Apolipoprotein A-I / Q000378:metabolism; D016633:Apolipoprotein A-II / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism*; D004038:Diet, Reducing; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D015431:Weight Loss / Q000502:physiology
chemical_list: D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D008076:Cholesterol, HDL; D000217:Acyltransferases; D008049:Lipase