title: Effects of diazepam and D-amphetamine on rhythmic pattern of eye movements in goldfish.
abstract: The effects of diazepam and D-amphetamine on spontaneous, vestibular- and visually-induced eye movements were studied in the restrained goldfish. These animals showed a stereotyped pattern of spontaneous eye movements that scanned the visual field in the horizontal plane. Fourier analysis of these eye movements revealed a rhythmic pattern of about 5 cycles per minute, whose frequency increased to double and decreased to half following treatment with diazepam and D-amphetamine, respectively. However, the fast and slow components of vestibulo-ocular and optokinetic reflexes, as well as peculiar blink-like movements, remained unchanged at the same drug doses. These results suggest the presence of a central pattern generator for spontaneous eye movements in the goldfish, whose oscillation frequency is pharmacologically modifiable.
authors.affiliation: Department of Animal Physiology and Biology, University of Seville, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Salas
authors.forename: F
authors.initials: F
authors.lastname: Navarro
authors.forename: B
authors.initials: B
authors.lastname: Torres
authors.forename: J M
authors.initials: JM
authors.lastname: Delgado-Garcia
mesh_terms: D000818:Animals; D001767:Blinking / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology*; D005133:Eye Movements / Q000187:drug effects*; D006054:Goldfish / Q000502:physiology*; D010507:Periodicity
chemical_list: D003975:Diazepam; D003913:Dextroamphetamine