[Pleural fibrosis in asbestosis and ventilatory function: a study of 50 cases].
The importance of non-malignant pleural fibrosis in asbestosis in relation to respiratory function is still open to debate because of the differing results obtained in studies of different population groups. In the present study we selected 50 subjects with occupational exposure to asbestos presenting mono- or bilateral pleural fibrosis at X-ray but without lung impairment. Each subject underwent bronchial lavage and ventilatory function tests. The subjects were divided into 4 groups on the basis of the degree of pleural alterations according to the ILO Classification of Pneumoconioses. The results revealed that the mean values of CV and FEV1 in each group were within physiological limits. Moreover, analysis of the type of lung function showed a normal situation in 64% and restricted function in 28% of the cases. The prevalence of the latter finding was not correlated to the severity of pleural fibrosis in the various groups. Also, comparison between severity of pleural fibrosis and number of asbestos bodies/ml of BAL liquid on the one hand and frequency of alveolitis on the other did not reveal any relationship. Therefore, the onset of pleural fibrosis appears to be independent of the quantity of inhaled asbestos fibres and due to different mechanisms from those leading to lung fibrosis. In practice, a correct interpretation of the presence of pleural fibrosis from a clinical and prognostic viewpoint also requires other investigations such as BAL and a complete respiratory function study.
Tomasini
M
M
Centro di studio e ricerca sugli effetti biologici delle polveri inalate, Università di Milano.
Rivolta
G
G
Calori
A
A
Nicoli
E
E
Ferretti
G
G
Chiappino
G
G
D000328:Adult; D000368:Aged; D001195:Asbestosis / Q000145:classification / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D005260:Female; D005355:Fibrosis / Q000145:classification / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010994:Pleura / Q000473:pathology*; D012129:Respiratory Function Tests
Fibrosi pleuriche asbestosiche e funzione ventilatoria: studio di 50 casi.