Exocytosis upon osmotic swelling in human epithelial cells.
Upon osmotic swelling human epithelial cells exhibited significant increases in the membrane capacitance. Evidence for exocytosis includes its dependency on temperature, cytosolic Ca2+ and ATP as well as its sensitivity to guanosine 5'-O-(3-thio)triphosphate (GTP gamma S) and N-ethylmaleimide (NEM). A role of the osmotic exocytosis in the subsequent cell volume regulation is suggested.
Okada
Y
Y
Department of Physiology, Kyoto University Faculty of Medicine, Japan.
Hazama
A
A
Hashimoto
A
A
Maruyama
Y
Y
Kubo
M
M
D000255:Adenosine Triphosphate / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology*; D004553:Electric Conductivity; D004848:Epithelium / Q000502:physiology; D005089:Exocytosis; D006801:Humans; D009997:Osmotic Pressure; D013696:Temperature
D000255:Adenosine Triphosphate; D002118:Calcium