Dimethylsulfoxide enhances the absorption of chemotherapeutic drug instilled into the bladder.
We examined the effect of dimethylsulfoxide (DMSO) on the absorption of a chemotherapeutic drug instilled into the bladder. Female Wistar rats with bladder tumors underwent intravesical instillation of normal saline (S group) or 50% DMSO (D group) prior to the administration of pirarubicin (tetrahydropyranyl-Adriamycin). The absorption of pirarubicin was estimated histologically by observing its fluorescence. In the S group, fluorescence of pirarubicin was observed only in the epithelial layer of normal or hyperplastic regions and in the cells of superficial layers of the tumor. In the D group fluorescence was observed in the entire bladder wall of normal or hyperplastic regions and extended to deeper regions of the tumors than in the S group. These findings indicate enhancement of the absorption of pirarubicin by pretreatment with DMSO.
Hashimoto
H
H
Department of Urology, Asahikawa Medical College, Japan.
Tokunaka
S
S
Sasaki
M
M
Nishihara
M
M
Yachiku
S
S
D000042:Absorption / Q000187:drug effects; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D008856:Microscopy, Fluorescence; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000378:metabolism
D004317:Doxorubicin; C027260:pirarubicin; D004121:Dimethyl Sulfoxide