title: Multiple space-occupying lesions of the spleen in a case of Gaucher's disease.
abstract: A 50-year-old female patient was admitted because of an enormously enlarged spleen and thrombocytopenia. Ultrasonography and magnetic resonance imaging revealed multiple space-occupying lesions in the spleen. She was diagnosed as having Gaucher's disease based on the low level of beta-glucosidase activity in leukocytes and Gaucher's cells present in bone marrow aspirate. Severe hypersplenism necessitated splenectomy. Pathological studies of the excised spleen, including ultrastructural examinations, demonstrated that multiple space-occupying lesions in the spleen were composed of typical Gaucher cells.
authors.affiliation: Second Department of Internal Medicine, Sanraku Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iwanami
authors.forename: K
authors.initials: K
authors.lastname: Namba
authors.forename: T
authors.initials: T
authors.lastname: Tsukada
authors.forename: T
authors.initials: T
authors.lastname: Hosaka
authors.forename: M
authors.initials: M
authors.lastname: Tagami
authors.forename: A
authors.initials: A
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Terada
mesh_terms: D005260:Female; D005776:Gaucher Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D013154:Spleen / Q000473:pathology*; D014463:Ultrasonography