title: Prospective cerebral MR study of HIV seropositive and seronegative men: correlation of MR findings with neurologic, neuropsychologic, and cerebrospinal fluid analysis.
abstract: OBJECTIVE
  As part of a longitudinal study of human immunodeficiency virus type 1 (HIV) infection, we attempted to identify early cerebral MR findings that might correlate to clinical evidence of central nervous system involvement.
  
  
  METHODS
  We studied 65 seropositive and 40 seronegative homosexual males using cranial MR, neurologic, immunologic, and neuropsychologic examinations.
  
  
  RESULTS
  The incidence of mildly enlarged ventricles, sulci, and punctate areas of abnormal signal in both groups was similar in both groups. Diffuse, poorly defined areas of abnormal white matter signal were difficult to consistently identify in seropositives. Enlarged adenoidal lymphoid tissue was found in 30 (46%) of seropositives and 2 (5%) of seronegatives (P = .0001). The incidence of sinus inflammatory change was similar in the two groups.
  
  
  CONCLUSIONS
  MR of intracranial contents is substantially normal in a non-AIDS HIV(+) population.
authors.affiliation: Department of Radiology, University of Washington School of Medicine, Seattle.
authors.forename: W A
authors.initials: WA
authors.lastname: Cohen
authors.forename: K R
authors.initials: KR
authors.lastname: Maravilla
authors.forename: R
authors.initials: R
authors.lastname: Gerlach
authors.forename: K
authors.initials: K
authors.lastname: Claypoole
authors.forename: A C
authors.initials: AC
authors.lastname: Collier
authors.forename: C
authors.initials: C
authors.lastname: Marra
authors.forename: C
authors.initials: C
authors.lastname: Maxwell
authors.forename: R W
authors.initials: RW
authors.lastname: Coombs
authors.forename: W T
authors.initials: WT
authors.lastname: Longstreth
authors.forename: B D
authors.initials: BD
authors.lastname: Townes
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016655:HIV Core Protein p24 / Q000097:blood / Q000134:cerebrospinal fluid*; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies
chemical_list: D016655:HIV Core Protein p24