title: Detection of selenium in generalized and localized argyria: report of four cases with X-ray microanalysis.
abstract: Electron microscopic and X-ray microanalytic studies were performed on four cases of argyria; one generalized and three localized. Deposition of electron dense granules was predominantly found on elastic fibers and around basal laminas of secretory portions of eccrine glands, although the amount of deposition was much less in the case of generalized argyria. In all four cases, X-ray microanalysis revealed that the depositions consisted mainly of silver, selenium, and sulfur. The importance of selenium in the detoxification of heavy metals was discussed.
authors.affiliation: Department of Dermatology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: M
authors.initials: M
authors.lastname: Kumakiri
authors.forename: A
authors.initials: A
authors.lastname: Ohkawara
authors.forename: H
authors.initials: H
authors.lastname: Himeno
authors.forename: T
authors.initials: T
authors.lastname: Numata
authors.forename: R
authors.initials: R
authors.lastname: Adachi
mesh_terms: D015670:Acupuncture Therapy / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D001129:Argyria / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D003442:Crowns / Q000009:adverse effects*; D004577:Electron Probe Microanalysis / Q000379:methods; D004595:Electroplating; D005260:Female; D005881:Gingiva / Q000737:chemistry / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D005882:Gingival Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D012643:Selenium / Q000737:chemistry / Q000378:metabolism*; D012834:Silver / Q000009:adverse effects* / Q000737:chemistry / Q000378:metabolism; D012867:Skin / Q000737:chemistry / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D013455:Sulfur / Q000737:chemistry / Q000378:metabolism*
chemical_list: D012834:Silver; D013455:Sulfur; D012643:Selenium