title: Endoscopic management of bronchial stenosis after double lung transplantation.
abstract: Double lung transplantation with bilateral bronchial sutures is an increasingly popular therapeutic alternative for endstage, bilateral, septic pulmonary disease; however, surgical outcome has been hampered by mechanical complications at the level of the airway anastomoses. In our institution, therefore, the protocol for surveillance includes frequent flexible fiberoptic and rigid bronchoscopy under general anesthesia in all patients. Since 1988, there were 24 double lung transplantations (mean age, 19 yr) performed at the University of Marseille Hospitals using bilateral sutures without omental wrapping. Nineteen patients had cystic fibrosis; of the ten individuals (53 percent) with cystic fibrosis who ultimately developed bronchial stenosis, six required therapeutic endoscopic intervention including dilatation or Nd:YAG laser resection. Five patients required endobronchial silicone stents. Statistically significant risk factors for postsurgical airway narrowing included young age (mean, 14.3 yr vs 24.0 yr in patients without stenosis) and prolonged mechanical ventilation prior to transplant (all five patients ventilated before surgery developed stenosis). Results of interventional bronchoscopy were good, and an excellent level of physical activity was maintained in most patients. A team familiar with all aspects of therapeutic bronchoscopy is essential to ensure proper management of airway complications in patients after lung transplantation.
authors.affiliation: Department of Laser and Thoracic Endoscopy, Hôpital Sainte Marguerite, CHU Sud, Marseille, France.
authors.forename: H G
authors.initials: HG
authors.lastname: Colt
authors.forename: J P
authors.initials: JP
authors.lastname: Janssen
authors.forename: J F
authors.initials: JF
authors.lastname: Dumon
authors.forename: M J
authors.initials: MJ
authors.lastname: Noirclerc
mesh_terms: D000293:Adolescent; D000328:Adult; D001982:Bronchial Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D001989:Bronchiolitis Obliterans / Q000601:surgery; D001999:Bronchoscopy; D002648:Child; D003251:Constriction, Pathologic / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D003550:Cystic Fibrosis / Q000601:surgery; D004106:Dilatation; D005260:Female; D006801:Humans; D053685:Laser Therapy; D016040:Lung Transplantation / Q000009:adverse effects* / Q000473:pathology; D008297:Male; D012307:Risk Factors; D015607:Stents