title: Effect of Norplant-2 rods on liver, lipid and carbohydrate metabolism.
abstract: The effect of Norplant-2 rods on liver, lipid and carbohydrate metabolism was evaluated in 100 women using Norplant-2 rods. Besides a significant increase in serum bilirubin, there was no other obvious evidence to suggest any possible hepatocellular dysfunction with the use of Norplant-2 rods. As regards lipid metabolism, decreases in total triglycerides, cholesterol and LDL-cholesterol and HDL-cholesterol were initially seen. These parameters returned to their preinsertion mean at the end of five years. As a result, the value of the HDL-cholesterol/total cholesterol - HDL-cholesterol and LDL-cholesterol/HDL-cholesterol ratios remained around their preinsertion value at the end of five years. All this appears to indicate that the use of Norplant-2 rods is not directly contributory to cardiovascular risk. The use of Norplant-2 rods was not associated with any significant effect on carbohydrate metabolism.
authors.affiliation: Department of Obstetrics and Gynaecology, National University of Singapore.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: O A
authors.initials: OA
authors.lastname: Viegas
authors.forename: D
authors.initials: D
authors.lastname: Loke
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D001210:Asia, Southeastern; D001663:Bilirubin / Q000097:blood; D050260:Carbohydrate Metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003271:Contraceptive Agents, Female / Q000494:pharmacology; D004343:Drug Implants; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000494:pharmacology*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003271:Contraceptive Agents, Female; D004343:Drug Implants; D014280:Triglycerides; D016912:Levonorgestrel; D002784:Cholesterol; D001663:Bilirubin