title: Simultaneous induction of multiple follicular development with gonadotrophins and steroid replacement for in-vitro fertilization.
abstract: Simultaneous administration of follicle stimulating hormone, oestradiol valerate and progesterone was employed in a patient with a possible enzymatic deficiency involving low production of oestradiol. The patient became pregnant after in-vitro fertilization. This case demonstrates that this treatment is useful in women with low oestradiol production and subsequent inadequate endometrial development; it also illustrates the role of oestradiol in follicular development and questions the importance of serum oestradiol measurements in the monitoring of ovulation induction.
authors.affiliation: Department of Paediatrics, Valencia University School of Medicine, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Pellicer
authors.forename: M J
authors.initials: MJ
authors.lastname: De los Santos
authors.forename: J
authors.initials: J
authors.lastname: Remohí
mesh_terms: D000328:Adult; D000446:Aldehyde-Lyases / Q000172:deficiency; D003577:Cytochrome P-450 Enzyme System / Q000172:deficiency; D004958:Estradiol / Q000097:blood / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D006080:Ovarian Follicle / Q000187:drug effects*; D010062:Ovulation Induction / Q000379:methods*; D011374:Progesterone / Q000627:therapeutic use*; D013254:Steroid 17-alpha-Hydroxylase; D013997:Time Factors
chemical_list: D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone; D003577:Cytochrome P-450 Enzyme System; D013254:Steroid 17-alpha-Hydroxylase; D000446:Aldehyde-Lyases