title: A macrolide 3-O-acyltransferase gene from the midecamycin-producing species Streptomyces mycarofaciens.
abstract: The Streptomyces mycarofaciens mdmB gene encodes a 3-O-acyltransferase that catalyzes the addition of acetyl and propionyl groups to position 3 of the lactone ring in 16-member macrolide antibiotics like midecamycin and spiramycin. A putative O-methyltransferase gene (mdmC) is immediately downstream of mdmB, and both of these genes are closely linked to the mdmA midecamycin resistance gene.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Hara
authors.forename: C R
authors.initials: CR
authors.lastname: Hutchinson
mesh_terms: D000123:Acetyltransferases / Q000235:genetics*; D000595:Amino Acid Sequence; D003001:Cloning, Molecular; D005798:Genes, Bacterial; D007933:Leucomycins / Q000096:biosynthesis*; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D013302:Streptomyces / Q000235:genetics*
chemical_list: D007933:Leucomycins; D000123:Acetyltransferases; C026483:midecamycin