title: [Experimental and clinical studies on pancreatic duct obstruction in preventing pancreatic fistula formation].
abstract: Even after prolonged use in clinical practice, obstruction of the pancreatic duct in preventing fistula formation still lacks solid proof. Sixteen dogs were randomized into an pancreatic duct obstruction group and a control group. Four to 8 ml of silicon gel was injected into the pancreatic duct in the former group while the latter group received exploratory laparotomy only. The pancreas was examined histopathologically 1, 3, 5, 7 and 9 months after operation. It was shown that the exocrine glands underwent marked atrophy but the endocrine glands showed only mild damage. Clinical studies on 27 patients who were operated for pancreatic cancers and diseases showed that pancreatic fistula developed in 7.7% of patients (1/13) in the obstruction group and 21% (3/14) in the control group.
authors.affiliation: Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
authors.forename: J H
authors.initials: JH
authors.lastname: Xu
mesh_terms: D000818:Animals; D004285:Dogs; D004621:Embolization, Therapeutic; D006801:Humans; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D010183:Pancreatic Ducts; D010185:Pancreatic Fistula / Q000517:prevention & control*; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000601:surgery