title: An investigation of the relationship between microbial and particulate indoor air pollution and the sick building syndrome.
abstract: The sick building syndrome has been the subject of research for approximately 10 years. Although it is often suggested that symptoms in office workers are due to circulating micro-organisms or particles, epidemiological studies investigating the relationship between them have been lacking. This cross-sectional study has combined medical and aerobiological assessments of offices in Great Britain and has found that, although airborne particulates and micro-organisms are unlikely to be the sole cause of the sick building syndrome, positive associations between symptom prevalence rates and levels of airborne viable bacteria and fungi within groups of buildings with similar ventilation systems, suggest a possible causal link that should be explored.
authors.affiliation: Division of Environmental and Occupational Medicine, Medical School, Newcastle-Upon-Tyne, U.K.
authors.forename: J
authors.initials: J
authors.lastname: Harrison
authors.forename: C A
authors.initials: CA
authors.lastname: Pickering
authors.forename: E B
authors.initials: EB
authors.lastname: Faragher
authors.forename: P K
authors.initials: PK
authors.lastname: Austwick
authors.forename: S A
authors.initials: SA
authors.lastname: Little
authors.forename: L
authors.initials: L
authors.lastname: Lawton
mesh_terms: D000391:Air Microbiology; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000704:Analysis of Variance; D001419:Bacteria / Q000302:isolation & purification*; D003430:Cross-Sectional Studies; D005658:Fungi / Q000302:isolation & purification*; D006801:Humans; D009784:Occupational Diseases / Q000382:microbiology*; D014691:Ventilation / Q000379:methods