Cerebellar syndrome in myxoedema revisited: a published case with carcinomatosis and multiple system atrophy at necropsy.
One of six patients in a 1960 paper on "Cerebellar syndrome in myxoedema" was subsequently found to have adenocarcinoma. General post-mortem revealed carcinomatosis and basal pneumonia. Neuropathological examination revealed the changes of multiple system atrophy. The relationship between hypothyroidism, carcinoma, and cerebellar, pontine and striatonigral degeneration is discussed.
Quinn
N
N
National Hospital for Neurology and Neurosurgery, London, UK.
Barnard
R O
RO
Kelly
R E
RE
D000230:Adenocarcinoma / Q000473:pathology / Q000503:physiopathology*; D000368:Aged; D001284:Atrophy; D001933:Brain Stem / Q000473:pathology; D002524:Cerebellar Ataxia / Q000473:pathology / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000473:pathology / Q000503:physiopathology*; D009410:Nerve Degeneration / Q000502:physiology*; D009460:Neurologic Examination; D009849:Olivopontocerebellar Atrophies / Q000473:pathology / Q000503:physiopathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology / Q000503:physiopathology*; D013274:Stomach Neoplasms / Q000473:pathology / Q000503:physiopathology*; D013961:Thyroid Gland / Q000473:pathology