title: Architecture and design of the nuclear pore complex.
abstract: A three-dimensional analysis of the nuclear pore complex reveals the underlying, highly symmetric framework of this supramolecular assembly, how it is anchored in the nuclear membrane, and how it is built from many distinct, interconnected subunits. The arrangement of the subunits within the membrane pore creates a large central channel, through which active nucleocytoplasmic transport is known to occur, and eight smaller peripheral channels that are probable routes for passive diffusion of ions and small molecules.
authors.affiliation: Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037.
authors.forename: J E
authors.initials: JE
authors.lastname: Hinshaw
authors.forename: B O
authors.initials: BO
authors.lastname: Carragher
authors.forename: R A
authors.initials: RA
authors.lastname: Milligan
mesh_terms: D000818:Animals; D005260:Female; D007091:Image Processing, Computer-Assisted; D046911:Macromolecular Substances; D008968:Molecular Conformation; D009685:Nuclear Envelope / Q000648:ultrastructure*; D009865:Oocytes; D014981:Xenopus
chemical_list: D046911:Macromolecular Substances