Additive effects of cisplatin and radiation in human tumor cells under oxic conditions.
The interaction of cisplatin and irradiation was studied in vitro in four human cell lines. Additive effects were observed for the combination given either simultaneously or sequentially. No influence on recovery was seen in split-dose experiments. It is concluded that radiosensitization cannot be presumed in every clinical setting of combined treatment with radiation and cisplatin.
Flentje
M
M
Department of Clinical Radiology, University of Heidelberg, F.R.G.
Eble
M
M
Haner
U
U
Trinh
S
S
Wannenmacher
M
M
D002470:Cell Survival; D002945:Cisplatin / Q000494:pharmacology*; D003037:Cobalt Radioisotopes; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D066298:In Vitro Techniques; D011867:Radioisotope Teletherapy; D014407:Tumor Cells, Cultured
D003037:Cobalt Radioisotopes; D002945:Cisplatin