Effects of soman on norepinephrine uptake and electrically stimulated release from human uterine arteries.
The effects of soman on the uptake and electrically induced release of norepinephrine (noradrenaline) from isolated human uterine artery have been investigated. Soman did not alter the uptake of norepinephrine by human uterine artery, but reduced the electrically induced release of norepinephrine from the artery. This reduced norepinephrine release may augment the fall in blood pressure induced by accumulated acetylcholine stimulating muscarinic receptors following cholinesterase inhibition.
Hu
C Y
CY
College of Pharmacy, University of Oklahoma, Oklahoma City 73190.
Robinson
C P
CP
D000328:Adult; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009638:Norepinephrine / Q000493:pharmacokinetics*; D012999:Soman / Q000494:pharmacology*; D014316:Tritium; D014599:Uterus / Q000098:blood supply
D014316:Tritium; D012999:Soman; D009638:Norepinephrine