Use of rats to compare atrophic rhinitis vaccines for protection against effects of heat-labile protein toxin produced by Pasteurella multocida serogroup D.
Four bacterin-toxoid and three bacterin commercial vaccines against atrophic rhinitis were tested in rats for their capacity to immunize against the lethal and systemic effects of purified heat-labile protein toxin (D-toxin) produced by Pasteurella multocida serogroup D. Only one bacterin-toxoid vaccine stimulated sufficient immunity to prevent the death of all rats challenged with D-toxin. None of the vaccines prevented weight loss, leukocytosis or increases in serum complement titers in rats challenged with D-toxin. Rats provide an inexpensive animal model for testing the capacity of vaccines to generate antitoxic immunity against the lethal and systemic effects of D-toxin.
Thurston
J R
JR
Avian Diseases Research Unit, US Department of Agriculture, Ames, IA 50010.
Rimler
R B
RB
Ackermann
M R
MR
Cheville
N F
NF
D000818:Animals; D001426:Bacterial Proteins / Q000633:toxicity*; D001427:Bacterial Toxins / Q000633:toxicity*; D003165:Complement System Proteins / Q000032:analysis; D008297:Male; D016979:Pasteurella multocida / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012222:Rhinitis, Atrophic / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014121:Toxoids / Q000633:toxicity; D014612:Vaccines / Q000008:administration & dosage*
D001426:Bacterial Proteins; D001427:Bacterial Toxins; C062258:Pasteurella multocida toxin; D014121:Toxoids; D014612:Vaccines; D003165:Complement System Proteins