In vivo effects of indomethacin--II. Antioxidant enzymes in metal-deficient rats.
1. The in vivo effects of indomethacin on the activity of antioxidant enzymes in erythrocytes, liver and small intestinal mucosa of rats fed a metal-deficient diet were studied. 2. Metal deficiency led to a significant decrease in the activity of the enzymes studied. 3. Neither with the "ulcerogenic" nor with the "therapeutic" dose of indomethacin significant alterations in the enzyme activity were observed. 4. The oral treatment of metal-deficient rats with a copper complex of indomethacin caused a significant increase in the activity of the enzymes studied. 5. The results suggest the participation of indomethacin in the regulation and redistribution of metals in the organism, which is probably effected through in vivo chelation of endogenous metals.
Kirkova
M
M
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Kassabova
T
T
Russanov
E
E
D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004032:Diet; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008670:Metals / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism
D006454:Hemoglobins; D008670:Metals; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D007213:Indomethacin