[Induction of sarcoma by resorbable osteosynthesis material in the rat. A preliminary report].
In an experiment testing the resorption of Poly-l-lactate in the back muscles of Cara rats a foreign body sarcoma occurred in two rats. 20 months after implantation of a body of high molecular weight poly-l-lactate a malignant fibrous histiocytoma developed in one rat. A soft tissue tumor, which was classified according to the immune-histiochemical analysis as a neurogenic sarcoma, developed 23 months after the implantation of a body of injection-casted poly-l-lactate of high molecular weight in a second rat.
Hoppert
T
T
II. Chirurgische Klinik des Klinikums Bayreuth, Universität Würzburg.
Pistner
H
H
Stolte
M
M
Mühling
J
J
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000473:pathology; D005549:Foreign-Body Reaction / Q000473:pathology; D005593:Fracture Fixation, Internal / Q000295:instrumentation*; D009132:Muscles / Q000473:pathology; D011091:Polyesters / Q000633:toxicity*; D019736:Prostheses and Implants; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000139:chemically induced* / Q000473:pathology
D001672:Biocompatible Materials; D014408:Biomarkers, Tumor; D011091:Polyesters; C033616:poly(lactide)
Sarkomauslösung durch resorbierbares Osteosynthesematerial bei der Ratte. Eine vorläufige Mitteilung.