title: Droloxifene--a new anti-estrogen. A phase II study in advanced breast cancer.
abstract: Twenty-six patients with advanced breast cancer were treated with a new anti-estrogen, Droloxifene (3-hydroxy-tamoxifen). They had all used tamoxifen either in the adjuvant or the advanced situation. The dose schedule was 100 mg orally daily. Partial remissions were observed in 4 (15%) of the patients, and in another 5 patients stable disease (greater than 24 weeks of duration) was observed. Three of the responders were resistant to tamoxifen. Fourteen of the 26 patients had no side-effect. In 2 patients therapy had to be stopped due to fatigue. Droloxifene seems to be an interesting new anti-estrogen which should be further exploited.
authors.affiliation: Dept. of Oncology, Norwegian Radium Hospital, Montebello, Oslo.
authors.forename: H
authors.initials: H
authors.lastname: Haarstad
authors.forename: S
authors.initials: S
authors.lastname: Gundersen
authors.forename: E
authors.initials: E
authors.lastname: Wist
authors.forename: N
authors.initials: N
authors.lastname: Raabe
authors.forename: O
authors.initials: O
authors.lastname: Mella
authors.forename: S
authors.initials: S
authors.lastname: Kvinnsland
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004341:Drug Evaluation; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004965:Estrogen Antagonists; D013629:Tamoxifen; C038345:droloxifene