title: Relationship between the hydrophobic and hydrophilic molecular parameters of some monoamine oxidase inhibitory drugs, determined by means of adsorptive and reversed-phase thin-layer chromatography.
abstract: The absorption capacity, the specific hydrophilic surface area, the lipophilicity and the specific hydrophobic surface area of 17 monoamine oxidase inhibitory drugs were determined by means of adsorptive and reversed-phase thin-layer chromatography for future application of these molecular parameters in quantitative structure-activity relationship studies. Principal component analysis suggests that most of the physicochemical parameters have a different information content, and their application in the elucidation of their mode of action is therefore justified.
authors.affiliation: Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
authors.forename: T
authors.initials: T
authors.lastname: Cserháti
authors.forename: K
authors.initials: K
authors.lastname: Magyar
mesh_terms: D000327:Adsorption; D002855:Chromatography, Thin Layer / Q000379:methods; D015394:Molecular Structure; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D008996:Monoamine Oxidase Inhibitors; D014867:Water