title: Comparative sensitivity study of Clostridium perfringens towards 16 antibiotics from different classes.
abstract: A series of 16 antibiotics from different classes (5-nitro imidazoles, beta-lactams, cyclins, macrolids, chloramphenicol) was examined for their bacteriostatic and bactericidal activities on 45 strains of Clostridium perfringens, with determination of MIC and MBC values. Several techniques of multivariate analysis were used in order to visualize differentiations in sensitivity profiles: Principal component analysis (PCA) and preferentially Correspondence factorial analysis (CFA). This approach revealed the efficacy of antibiotics from both general and family classifications.
authors.affiliation: Laboratoire de Chimie Organique, Faculté de Pharmacie, Illkirch, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Rival
authors.forename: G
authors.initials: G
authors.lastname: Grassy
authors.forename: M
authors.initials: M
authors.lastname: Simeon de Buochberg
authors.forename: G
authors.initials: G
authors.lastname: Dusart
mesh_terms: D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents