title: [Germinal tumors of the mediastinum. Therapeutic strategy, prognosis, biology].
abstract: Mediastinal germ cell tumors have a poor prognosis. Cisplatin containing chemotherapy combined with either primary or post-chemotherapy exeresis of the disease can induce a 50% cure rate. Acute leukemia is often associated with these tumors. In these cases, a clonal evolution from the germ cell tumor has been demonstrated.
authors.affiliation: Département de Médecine, Institut Gustave-Roussy, Villejuif.
authors.forename: J P
authors.initials: JP
authors.lastname: Droz
authors.forename: P
authors.initials: P
authors.lastname: Ruffié
mesh_terms: D014408:Biomarkers, Tumor; D002945:Cisplatin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004407:Dysgerminoma / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D006801:Humans; D007621:Karyotyping; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D009367:Neoplasm Staging; D011379:Prognosis; D013514:Surgical Procedures, Operative / Q000592:standards; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D002945:Cisplatin
vernacular_title: Tumeurs germinales du médiastin. Stratégie thérapeutique, pronostic, biologie.