title: hsp70 synthesis in Schwann cells in response to heat shock and infection with Mycobacterium leprae.
abstract: Induction of heat shock protein synthesis was monitored in murine and monkey Schwann cells exposed to elevated temperatures. Synthesis of the stress-inducible 70-kDa heat shock protein (hsp70) was detected in both murine and primate Schwann cells by metabolic labelling and by immunoblotting with a specific monoclonal antibody. hsp70 synthesis was also induced in Schwann cells after infection with Mycobacterium leprae and was detected from 24 h to 1 week postinfection. These results are discussed with respect to the possible role of heat shock proteins in immunopathological events associated with the clinical manifestations of leprosy.
authors.affiliation: Microbiology Division, National Institute of Immunology, Shahid Jeet Singh Marg, New Delhi, India.
authors.forename: Y
authors.initials: Y
authors.lastname: Mistry
authors.forename: D B
authors.initials: DB
authors.lastname: Young
authors.forename: R
authors.initials: R
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006358:Hot Temperature; D007918:Leprosy / Q000276:immunology / Q000378:metabolism*; D008253:Macaca mulatta; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis; D012583:Schwann Cells / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins