title: [Cytogenetic marker del(12p) in a case of acute myeloid leukemia M4 with eosinophilia and inv(16)].
abstract: A 35-year-old Spanish female having acute myelomonocytic leukaemia with marrow eosinophilia is reported. The karyotype revealed the specific chromosomal abnormality associated with this disorder, inv(16), and a less-specific myelodysplastic cytogenetic marker, del(12p). We have reviewed the published cases in order to elucidate the possible significance of presenting a 12p deletion (nonrandomly associated with chronic myelomonocytic leukaemia) together with other chromosomal rearrangements.
authors.affiliation: Departamento de Genética, Universidad de Navarra, Clínica Universitaria, Pamplona.
authors.forename: J C
authors.initials: JC
authors.lastname: Cigudosa
authors.forename: M J
authors.initials: MJ
authors.lastname: Calasanz
authors.forename: A
authors.initials: A
authors.lastname: Gullón
authors.forename: B
authors.initials: B
authors.lastname: Cuesta
authors.forename: J
authors.initials: J
authors.lastname: Rifón
authors.forename: E
authors.initials: E
authors.lastname: Rocha
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D002872:Chromosome Deletion; D007446:Chromosome Inversion; D002881:Chromosomes, Human, Pair 12 / Q000648:ultrastructure*; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D002999:Clone Cells / Q000648:ultrastructure; D005260:Female; D005819:Genetic Markers; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D014411:Neoplastic Stem Cells / Q000648:ultrastructure
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers
vernacular_title: Marcador citogenético del(12p) en un caso de leucemia mieloide aguda M4 con eosinofilia e inv(16).