title: Successful use of liposome encapsulated amphotericin to treat invasive aspergillosis following failure of conventional amphotericin.
abstract: We describe a case of proven invasive pulmonary aspergillosis in a neutropenic patient in whom disease progression occurred during treatment with conventional amphotericin B despite neutrophil recovery. Treatment with liposomal encapsulated amphotericin B resulted in clinical and radiological improvement and the clearance of aspergillus spores from the sputum.
authors.affiliation: Department of Haematology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Richards
authors.forename: J F
authors.initials: JF
authors.lastname: Apperley
authors.forename: R E
authors.initials: RE
authors.lastname: Marcus
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001231:Aspergillus flavus; D001232:Aspergillus fumigatus; D004337:Drug Carriers; D006801:Humans; D008081:Liposomes; D008172:Lung Diseases, Fungal / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B