Parametric manipulations and fixed-interval self-stimulation.
Three experiments investigated hypothalamic self-stimulation under a fixed-interval (FI) reinforcement schedule. An FI 20-s schedule was chosen to reduce stimulation density in order to minimize the influence of priming effects or stimulation aftereffects that can affect responding under other schedules of reinforcement. The first experiment showed that the influence of train duration is greatest at levels up to 1 s and thereafter level off over a wide range of train durations (1-32 s). The second experiment showed that altering frequency, current, or pulse width produced almost identical changes in FI responding. These findings show that the neutral network subserving hypothalamic self-stimulation simply integrates the amount of charge over time. It is relatively insensitive to the combination of stimulation parameters that make up a given waveform. In the third experiment, the chronaxies from the strength-duration curves indicate the neural substrate supporting self-stimulation has a great current-integrating capacity. Together, these experiments show that varying the amount of brain stimulation produce large and consistent changes in a number of FI response measures. These measures effectively describe different attributes of FI performance and include response rate, the postreinforcement pause, interresponse times of short duration and the temporal distribution of responses within the interval.
Hunt
G E
GE
Department of Psychiatry, University of Sydney, New South Wales, Australia.
Atrens
D M
DM
D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology; D004558:Electric Stimulation; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D008297:Male; D008474:Medial Forebrain Bundle; D009042:Motivation; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule; D012653:Self Stimulation / Q000502:physiology*; D012684:Sensory Thresholds / Q000502:physiology