Regression and stabilization of coronary artery lesions. Angiographic trials move beyond the NCEP treatment guidelines.
National Cholesterol Education Program Guidelines for the diagnosis and treatment of hypercholesterolemia have been formulated from population studies relating coronary events to blood lipids. Such population studies may not be relevant to patients with established coronary disease. Recent coronary angiographic studies allow meaningful comparisons of small groups of patients. These studies suggest that atherosclerotic lesions in coronary arteries can be stabilized, and further, that regression of coronary lesions can occur. The cholesterol and LDL levels achieved in angiographic studies are well below NCEP guidelines. Careful attention to correcting lipid abnormalities in patients with established coronary disease may alter the course of their illness.
DeBoer
L W
LW
University of Nebraska Medical Center, Omaha 68198.
Vailas
L I
LI
D002784:Cholesterol / Q000097:blood; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D012307:Risk Factors
D002784:Cholesterol