Bolus dose with continuous infusion of midazolam as sedation for outpatient surgery.
This double-blind, randomised, cross-over trial in 41 patients for 3rd molar surgery compared the safety, amnesic properties and psychomotor recovery between a bolus injection of midazolam and a bolus injection followed by continuous infusion of midazolam. The latter showed good safety and better amnesia to events during the procedure, but prolonged the recovery time.
Luyk
N H
NH
University of Otago, Dunedin, New Zealand.
Zacharias
M
M
Wanwimolaruk
S
S
D000293:Adolescent; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000704:Analysis of Variance; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental / Q000379:methods; D000772:Anesthesia, Local / Q000379:methods; D016292:Procedural Sedation / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D005425:Flicker Fusion; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008568:Memory; D008874:Midazolam / Q000008:administration & dosage*; D008964:Molar, Third / Q000601:surgery*; D011930:Reaction Time; D014081:Tooth Extraction
D008874:Midazolam