[The detection of inflammation and the formation of HAMA following the administration of monoclonal antibody BW 250/183].
Experiences with the use of the 99mTc-labelled MAb BW 250/183 in the detection of inflammatory lesions are reported. In 160 of 354 investigated patients the results could be confirmed by other methods. The sensitivity (91%) and the specificity (82%) were very high for a diagnostic tool and were comparable with the results of other leukocyte scans as reported in the literature. The positive predictive value of the method was 93%. In 84 patients studied once and in 6 patients studied twice only one case of the latter group showed a positive HAMA response. It may be concluded that the detection of foci of inflammation with the 99mTc-labelled MAb BW 250/183 is of great diagnostic value and that its administration can be repeated without risk.
Berberich
R
R
Abteilung für Nuklearmedizin, Radiologische Klinik Homburg, FRG.
Hennes
P
P
Alexander
C
C
D000328:Adult; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D000911:Antibodies, Monoclonal; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000276:immunology; D008297:Male; D051379:Mice / Q000276:immunology; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013667:Technetium
D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D013667:Technetium
Entzündungsnachweis und HAMA-Bildung nach Applikation des monoklonalen Antikörpers BW 250/183.