title: Doxycycline plasma concentrations in macaws fed a medicate corn diet.
abstract: A trial was conducted to determine the doxycycline plasma concentrations attained by feeding a medicated corn diet to large psittacine birds. Doxycycline is the preferred drug for the treatment of chlamydiosis in psittacine birds. Healthy macaws were fed a 0.1% doxycycline-medicated corn diet for 45 days, and plasma doxycycline concentrations were determined by microbiological assay on treatment days 3, 15, 30, and 45. Plasma doxycycline concentrations exceeded 1 microgram/ml in 87% of the samples assayed. As blood concentrations of 1 microgram/ml are considered therapeutic, a doxycycline-medicated corn diet may be efficacious in the treatment of chlamydiosis in large psittacine birds.
authors.affiliation: Department of Companion Animal and Special Species Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
authors.forename: S E
authors.initials: SE
authors.lastname: Prus
authors.forename: S L
authors.initials: SL
authors.lastname: Clubb
authors.forename: K
authors.initials: K
authors.lastname: Flammer
mesh_terms: D000821:Animal Feed; D000818:Animals; D004318:Doxycycline / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D008297:Male; D011563:Psittaciformes / Q000097:blood / Q000378:metabolism*; D003313:Zea mays
chemical_list: D004318:Doxycycline