Effect of pre- and postganglionic lesioning of the trigeminal nerve on cerebral blood flow and glucose metabolism following a subarachnoid haemorrhage in the squirrel monkey.
Simultaneous cerebral blood flow (CBF) and glucose metabolism (CMRglu) studies with a double isotope autoradiographic technique were applied to squirrel monkeys submitted to a unilateral pre- or postganglionic trigeminal lesion. The CBF values were not affected following a pre- or postganglionic lesion per se. In contrast, there was a global increase in the cerebral glucose uptake of about 50% as compared to controls following both kinds of lesions. Following a subarachnoid haemorrhage (SAH) 2-4 weeks after pre- or postganglionic trigeminal lesioning, there was a decrease in CBF similar to that seen in the control group. In the animals with a preganglionic lesion, the 50% increase in glucose uptake was not further augmented by a SAH and the increase in CMRglu was comparable to that found in control SAH animals. In the postganglionically lesioned monkeys, a SAH induced an additional increase in glucose uptake of about 50%. The findings suggest that the trigeminal system is involved in the regulation of cerebral metabolism via a brainstem centre.
Shiokawa
Y
Y
Neurosurgical Department, Karolinska Sjukhuset, Stockholm, Sweden.
Delgado-Zygmunt
T J
TJ
Arbab
M A
MA
Svendgaard
N A
NA
D000818:Animals; D001338:Autonomic Fibers, Postganglionic / Q000502:physiology*; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000098:blood supply*; D004734:Energy Metabolism / Q000502:physiology; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008442:Maxillary Nerve / Q000503:physiopathology; D009882:Ophthalmic Nerve / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D012453:Saimiri; D013126:Spinal Nerve Roots / Q000503:physiopathology; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*; D014276:Trigeminal Nerve / Q000503:physiopathology*
D001786:Blood Glucose