title: Periventricular neurocytoma: a pathological entity.
abstract: Three cases of periventricular neurocytomas are presented. All patients had a large but well-circumscribed, hyperdense tumor with insignificant contrast enhancement in the lateral and third ventricle, causing hydrocephalus. Calcification was present in one patient. Angiography revealed a blush tumor enhancement in two cases. Surgical removal was complete in two patients and incomplete in one. Light microscopy showed a cell pattern that resembled either ependymoma or oligodendroglioma. However, in all cases the tumor was confirmed to be a neurocytoma by immunocytochemical analysis that showed reactivity for synaptophysin and/or neuron-specific enolase in a high percentage of neoplastic cells. With respect to the literature it is concluded that neurocytomas represent an individual pathological entity of supratentorial midline tumors. Complete surgical removal without irradiation is the recommended treatment.
authors.affiliation: Department of Neurosurgery, Medical School, University of Tübingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Zentner
authors.forename: J
authors.initials: J
authors.lastname: Peiffer
authors.forename: W
authors.initials: W
authors.lastname: Roggendorf
authors.forename: E
authors.initials: E
authors.lastname: Grote
authors.forename: W
authors.initials: W
authors.lastname: Hassler
mesh_terms: D000328:Adult; D002551:Cerebral Ventricle Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009447:Neuroblastoma / Q000737:chemistry / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase