title: Synthetic studies toward 9-keto-cannabinoids.
abstract: 9-Keto-cannabinoid methyl ether, the precursor for many cannabinoid metabolites and analogues, was prepared from (+)-apoverbenone in 5 steps. This synthesis includes the condensation of apoverbenone with aryllithium followed by oxidation, hydrolysis of the MOM ether, acid-catalyzed cyclization, and metal ammonia reduction.
authors.affiliation: School of Chemistry, Kaohsiung Medical College, Taiwan, Republic of China.
authors.forename: M J
authors.initials: MJ
authors.lastname: Wu
authors.forename: J W
authors.initials: JW
authors.lastname: Huffman
mesh_terms: D013759:Dronabinol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008722:Methods
chemical_list: C070153:9-keto-cannabinoid methyl ether; D013759:Dronabinol