Morphine-ethanol interaction on body temperature.
1. The interaction between ethanol and morphine on core temperature was investigated in Swiss Webster mice. 2. Morphine (2.5-30 mg/kg) and ethanol (0.5-3.0 mg/g) administered individually resulted in a dose dependent decrease in body temperature. 3. When both drugs were injected simultaneously, body temperature decreased less than it would be expected to if the effects were additive. 4. Naloxone antagonized the hypothermic effect of morphine, but the hypothermic effect of ethanol and that of the combination of morphine plus ethanol was only reversed with high doses of naloxone (10 mg/kg). 5. Individual morphine and ethanol plasma levels were not significantly altered by their concomitant administration. 6. Binding of tritiated naloxone to opiate receptors in mouse brain membrane preparations was unchanged by pretreatment with ethanol (0.5 and 2 mg/g). 7. The interaction between morphine and ethanol was found to be less than additive and not related to pharmacokinetic changes of either drug.
Orts
A
A
Department of Anesthesiology, New York University Medical Center, NY 10016.
Alcaraz
C
C
Goldfrank
L
L
Turndorf
H
H
Puig
M M
MM
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009020:Morphine / Q000097:blood / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism
D011957:Receptors, Opioid; D009270:Naloxone; D000431:Ethanol; D009020:Morphine