Alterations at the rel locus in human lymphoma.
The rel proto-oncogene has been mapped to chromosome region 2p11.2-14, a site associated with nonrandom rearrangements in non-Hodgkin's lymphoma. We have characterized an abnormal rel mRNA from a cell line derived from a diffuse large cell lymphoma, in which the evolutionarily conserved N-terminal half of the rel coding region was fused with the C-terminal coding region of an unrelated gene. In addition, rearrangement or amplification of the rel locus was found in the lymphomatous tissue of two follicular and one diffuse large cell lymphoma. The findings suggest involvement of rel in the pathogenesis of large cell lymphoma.
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Department of Neoplastic Diseases, Hahnemann University School of Medicine, Philadelphia, Pennsylvania 19102-1192.
Thompson
J D
JD
Gorski
G K
GK
Rice
N R
NR
Mayer
M G
MG
Yunis
J J
JJ
D000595:Amino Acid Sequence; D001483:Base Sequence; D002869:Chromosome Aberrations; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D015342:DNA Probes; D004262:DNA Restriction Enzymes; D005784:Gene Amplification; D015321:Gene Rearrangement; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D020569:Proto-Oncogene Proteins c-rel; D011519:Proto-Oncogenes; D014162:Transfection; D014407:Tumor Cells, Cultured
D015342:DNA Probes; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D020569:Proto-Oncogene Proteins c-rel; D004262:DNA Restriction Enzymes