title: Serologic evidence of coronavirus infection in New York and New England dairy cattle with winter dysentery.
abstract: Acute and convalescent sera were collected from 8 dairy herds with classic clinical features of winter dysentery. An enzyme-linked immunosorbent assay was used to measure coronavirus antibody titers, employing calf diarrhea coronavirus as antigen. Twenty-two of the 35 animals tested (63%) showed a greater than or equal to 4-fold seroconversion. Adult cattle in all 8 herds seroconverted. These findings complement previously reported immunoperoxidase and electron microscopic evidence, suggesting an etiologic role for an enteric coronavirus in this disease.
authors.affiliation: Department of Pathobiology, University of Connecticut, Storrs 06269.
authors.forename: H J
authors.initials: HJ
authors.lastname: Van Kruiningen
authors.forename: V P
authors.initials: VP
authors.lastname: Castellano
authors.forename: A
authors.initials: A
authors.lastname: Torres
authors.forename: R L
authors.initials: RL
authors.lastname: Sharpee
mesh_terms: D000208:Acute Disease; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology*; D003237:Connecticut / Q000453:epidemiology; D003332:Coronaviridae / Q000276:immunology*; D003333:Coronaviridae Infections / Q000453:epidemiology / Q000662:veterinary*; D003967:Diarrhea / Q000453:epidemiology / Q000662:veterinary; D004403:Dysentery / Q000453:epidemiology / Q000662:veterinary*; D004797:Enzyme-Linked Immunosorbent Assay; D009518:New York / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral