title: Oxytocin but not vasopressin facilitates social recognition following injection into the medial preoptic area of the rat brain.
abstract: Social recognition of juvenile rats by adult male residents has been shown to be modulated by peripheral administration of neurohypophyseal hormones vasopressin and oxytocin. In the present study, the effects of these peptides on social recognition were investigated after local injection into the medial preoptic area of the hypothalamus. It was found that oxytocin given in a wide range of doses (0.3-1000 pg) facilitated social recognition. This effect was not blocked by pretreatment with oxytocin receptor antagonist desGly(NH2)9-d(CH2)5[Tyr(Me)2Thr4]OVT. Oxytocin injected into the septum in doses of 0.03-3 pg was not effective. Administration of vasopressin (100 or 1000 pg), [pGlu4,Cyt6]AVP-(4-8) (200 pg) or [pGlu4,Cyt6]AVP-(4-9) (200 pg) into the medial preoptic area did not influence social recognition. It is concluded that the medial preoptic area is a sensitive brain site for the oxytocin-induced facilitation of social recognition in rats.
authors.affiliation: Department of Pharmacology, Rudolf Magnus Institute, University of Utrecht, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Popik
authors.forename: J M
authors.initials: JM
authors.lastname: van Ree
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D007267:Injections; D008297:Male; D010121:Oxytocin / Q000008:administration & dosage / Q000494:pharmacology*; D011301:Preoptic Area; D051381:Rats; D011919:Rats, Inbred Strains; D018045:Receptors, Oxytocin; D012919:Social Behavior; D013268:Stimulation, Chemical
chemical_list: D057911:Angiotensin Receptor Antagonists; D018045:Receptors, Oxytocin; D001127:Arginine Vasopressin; D010121:Oxytocin