Uniporters and anion antiporters.
The past year has seen a flurry of activity in the area of protein-mediated hexose uniport. Topics of interest covered here include: structure-function studies; the interaction of glucose carriers with glycolytic enzymes; regulation of cell surface glucose-carrier concentrations by insulin and the signalling mechanisms involved; and the role of the glucose-carrier isoform, GLUT2, in pancreatic beta-cell glucose-dependent insulin secretion. Nucleoside uniport and Glu-Asp antiport are also discussed briefly.
Hebert
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Department of Biochemistry and Molecular Biology, University of Massachusetts Medical Centre, Worcester 01605.
Carruthers
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A
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000838:Anions / Q000378:metabolism; D017920:Antiporters; D016466:CHO Cells; D002352:Carrier Proteins / Q000378:metabolism*; D006224:Cricetinae; D003920:Diabetes Mellitus / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal; D005947:Glucose / Q000378:metabolism*; D006601:Hexoses / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D033703:Nucleoside Transport Proteins; D009705:Nucleosides / Q000378:metabolism; D011487:Protein Conformation; D051381:Rats; D011994:Recombinant Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000838:Anions; D017920:Antiporters; D002352:Carrier Proteins; D005656:Fungal Proteins; D006601:Hexoses; D007328:Insulin; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; D033703:Nucleoside Transport Proteins; D009705:Nucleosides; D011994:Recombinant Proteins; D005947:Glucose