title: Is there a relationship between 5-HT1B receptors and the mechanisms of action of antidepressant drugs in the learned helplessness paradigm in rats?
abstract: The present study was undertaken to investigate, in the learned helplessness paradigm, (1) the effects of CGS 12066B, a selective 5-HT1B receptor agonist administered alone, and (2) the effects of CGS 12066B co-administered with tricyclics (clomipramine, imipramine) or 5-HT re-uptake blockers (citalopram, fluvoxamine). The results showed that (1) the selective 5-HT1B agonist failed to reverse the escape deficit, and (2) in the drug interaction studies, CGS 12066B did not modify the ability of tricyclics to reverse the escape deficit. The 5-HT1B agonist, however, did significantly reduce the ability of 5-HT re-uptake blockers to reverse the escape deficit. These results suggest that modulation of 5-HT1B sites might modify the enhancement of 5-HT neurotransmission by antidepressants, particularly 5-HT re-uptake blockers.
authors.affiliation: Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: A J
authors.initials: AJ
authors.lastname: Puech
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D004597:Electroshock; D006380:Helplessness, Learned; D008297:Male; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D011810:Quinoxalines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C052561:CGS 12066B