[Diagnosis of fetal virus infections by in situ hybridization].
Non-radioactive in situ hybridization of formalin-fixed paraffin-embedded placental and foetal tissue, using virus-specific DNA or RNA probes, may be helpful for the diagnosis of foetal virus infection causing foetal hydrops, granulomatous placentitis and abortion. We present four cases of intrauterine CMV-, Parvo-B19- and Varicella-Zoster virus infection, in which this diagnostic method established detection of the virus.
Mehraein
Y
Y
Abteilung für Klinische Genetik der Philipps-Universität Marburg.
Rehder
H
H
Draeger
H G
HG
Froster-Iskenius
U G
UG
Schwinger
E
E
Holzgreve
W
W
D000328:Adult; D002644:Chickenpox / Q000473:pathology; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000473:pathology; D015342:DNA Probes; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000473:pathology; D010322:Parvoviridae Infections / Q000473:pathology; D016732:Parvovirus B19, Human / Q000302:isolation & purification; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology*; D011296:Prenatal Diagnosis; D015347:RNA Probes; D014777:Virus Diseases / Q000473:pathology*
D015342:DNA Probes; D015347:RNA Probes
Die Diagnostik fetaler Virusinfektionen durch In-situ-Hybridisierung.