High-performance liquid chromatographic determination of ganciclovir in plasma.
A rapid, selective and sensitive isocratic reversed-phase high-performance liquid chromatographic method for the determination of ganciclovir in plasma samples was developed. This method, which was applied to the analysis of plasma ganciclovir from heart transplant patients under ganciclovir therapy for cytomegalovirus infections, represents a suitable analytical tool for drug monitoring and pharmacokinetic investigations.
Boulieu
R
R
Institut des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Clinique, Lyon, France.
Bleyzac
N
N
Ferry
S
S
D002851:Chromatography, High Pressure Liquid; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology; D016903:Drug Monitoring; D015774:Ganciclovir / Q000097:blood* / Q000627:therapeutic use; D016027:Heart Transplantation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents
D007202:Indicators and Reagents; D015774:Ganciclovir