title: Tetramethylthiuram disulfide or dimethyldithiocarbamate induces the synthesis of cadystins, heavy metal chelating peptides, in Schizosaccharomyces pombe.
abstract: Tetramethylthiuram disulfide (TMTD) or dimethyldithiocarbamate (DMDTC) induces the synthesis of cadystins, a family of heavy metal chelating isopeptides with the formula (gamma-Glu-Cys)n-Gly (n = 2,3,4,...), in the fission yeast Schizosaccharomyces pombe. Amount of cadystins synthesized in TMTD or DMDTC treated cells is less than that synthesized in CdCl2 treated cells but much more than that synthesized in ZnCl2 or CuSO4 treated cells.
authors.affiliation: Department of Genetics, Institute for Developmental Research, Aichi Prefectural Colony, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Mutoh
authors.forename: M
authors.initials: M
authors.lastname: Kawabata
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000596:Amino Acids / Q000032:analysis; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology; D019256:Cadmium Chloride; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D002712:Chlorides / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003300:Copper / Q000494:pharmacology; D019327:Copper Sulfate; D004125:Dimethyldithiocarbamate / Q000494:pharmacology*; D005656:Fungal Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D047908:Intracellular Signaling Peptides and Proteins; D007700:Kinetics; D012568:Schizosaccharomyces / Q000187:drug effects / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins; D013893:Thiram / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology; D017967:Zinc Compounds
chemical_list: D000596:Amino Acids; D002352:Carrier Proteins; D002712:Chlorides; D004125:Dimethyldithiocarbamate; D005656:Fungal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D029702:Schizosaccharomyces pombe Proteins; D017967:Zinc Compounds; D002104:Cadmium; D013893:Thiram; D003300:Copper; C055088:cadystin protein, S pombe; C016837:zinc chloride; D015032:Zinc; D019256:Cadmium Chloride; D019327:Copper Sulfate