Effect of cinitapride in isolated ileum obtained from guinea-pigs treated with morphine.
1. Cinitapride enhanced the contractile response induced by electrical stimulation in the guinea-pig myenteric plexus-longitudinal muscle strip preparations. 2. The contractile force was significantly increased in strips pretreated with morphine "in vitro" and in tolerant strips. 3. However when tissues were obtained from tolerant guinea-pigs and morphine was not added to the organ bath (morphine-abstinence), the cinitapride effect was significantly decreased. 4. Although further work is required to explain the changes in the effect of cinitapride after acute morphine treatment and in morphine tolerant tissues, the changes observed suggest that some of the cinitapride effects could be linked with the peripheral opioid system.
Colado
M I
MI
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Alfaro
M J
MJ
del Val
V L
VL
Martín
M I
MI
D000818:Animals; D004361:Drug Tolerance; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009197:Myenteric Plexus / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects
D011957:Receptors, Opioid; D009020:Morphine