title: [Determinations of steroidal muscle relaxants and their metabolites].
abstract: Pancuronium, vecuronium and pipecuronium are quaternary ammonium steroidal neuromuscular blocking agents. These drugs are typical nondepolarizing muscle relaxants. The steroidal compounds and/or their metabolites have been determined using mass spectrometry or gas chromatography. In this review, these analytical methods and application of the methods to pharmacokinetics are introduced.
authors.affiliation: Department of Anesthesiology, School of Medicine, Keio University, Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.forename: K
authors.initials: K
authors.lastname: Uchida
mesh_terms: D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D000818:Animals; D006801:Humans; D010197:Pancuronium / Q000032:analysis* / Q000378:metabolism; D017300:Pipecuronium; D010879:Piperazines / Q000032:analysis* / Q000378:metabolism
chemical_list: D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D010197:Pancuronium