Effect of hydrogen fluoride inhalation on lipid metabolism in guinea pigs.
The action of fluoride in vivo (exposure 96 hrs to 7 mg/m3) on the metabolism of cyclic AMP and relationship between cAMP and lipid metabolism was investigated. The mean values for cAMP, non esterified fatty acids and cholesterol were significantly increased after hydrogen fluoride exposure. cAMP is directly responsible for the increased lipolysis. In animals exposed to HF, theophylline injection causes increases of non esterified fatty acids and not produces modification of cholesterol level.
Philibert
C
C
Department of Toxicology, Faculté de Pharmacie, Toulouse, France.
Dousset
J C
JC
Rioufol
C
C
Bourbon
P
P
D000280:Administration, Inhalation; D000818:Animals; D002784:Cholesterol / Q000097:blood; D000242:Cyclic AMP / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006168:Guinea Pigs; D006858:Hydrofluoric Acid / Q000008:administration & dosage* / Q000097:blood; D008055:Lipids / Q000097:blood*; D008452:Maximum Allowable Concentration
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D002784:Cholesterol; D000242:Cyclic AMP; D006858:Hydrofluoric Acid