The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogues.
Starting from benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro- pentofuranoside (4), the following 2'-deoxy nucleoside analogues have been synthesized: 4'-thiothymidine (8), 3'-azido-4'-thio- deoxythymidine (10), and (E)-5-(2-bromovinyl)-4'-thio-2'-deoxyuridine (22). The first compound is toxic, the second is not toxic nor has detectable biological activity, and the third is not toxic and has significant activity against some herpesviruses.
Dyson
M R
MR
School of Chemistry, University of Birmingham, England.
Coe
P L
PL
Walker
R T
RT
D000998:Antiviral Agents / Q000138:chemical synthesis; D003587:Cytomegalovirus / Q000187:drug effects; D006678:HIV / Q000187:drug effects; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D013872:Thionucleosides