Killer cell lines against Shope carcinoma cells in rabbits.
Killer cell activity against Shope carcinoma cells was not detected in PBL nor in spleen cells from tumor-bearing B/J rabbits, but was induced by in vitro culture of these cells in the presence of IL-2 and X-irradiated carcinoma cells. HTLV-I-transformed killer cell lines were successfully obtained by the culturing of PBL from an HTLV-I-infected and tumor-bearing Chbb:HM rabbit. These killer cells included large cells with azurophilic granules in the cytoplasm and with a reniform nucleus, thus resembling large granular lymphocytes. The killer activity was similar against the Vx2K cell line from a random-bred rabbit and SCB cell lines from an B/J rabbit, suggesting the absence of MHC restriction.
Takahashi
M
M
Department of Microbiology, Shiga University of Medical Science, Japan.
Yamade
I
I
Seto
A
A
D000818:Animals; D015139:Blotting, Southern; D002277:Carcinoma / Q000276:immunology*; D002460:Cell Line; D012777:Cottontail rabbit papillomavirus; D003602:Cytotoxicity, Immunologic; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology*; D011817:Rabbits; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D014412:Tumor Virus Infections / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta