Fibrolamellar carcinoma of the liver in a patient with Fanconi anemia.
A 9-year-old boy with Fanconi anemia treated with oxymethalone, a synthetic androgen, died of intracerebral hemorrhage. At autopsy, the liver contained several adenomas and a large fibrolamellar hepatocellular carcinoma, as well as phlebectatic peliosis hepatis. The 11 previously reported cases of hepatocellular carcinoma in Fanconi anemia were not, apparently, of the fibrolamellar type, which has a better prognosis, occurs in children of both sexes, and generally is not associated with cirrhosis. The malignant potential of primary liver tumors associated with Fanconi anemia as well as the nature of their relationship to Fanconi anemia and to anabolic steroid therapy is discussed.
LeBrun
D P
DP
Department of Pathology, Hospital for Sick Children, Toronto, Ontario, Canada.
Silver
M M
MM
Freedman
M H
MH
Phillips
M J
MJ
D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000473:pathology*; D002675:Child, Preschool; D005199:Fanconi Anemia / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male