Clustering of hepatocellular carcinoma in Alaska Native families.
Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969-1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.
Alberts
S R
SR
Arctic Investigations Program, Centers for Disease Control, Anchorage, Alaska 99501.
Lanier
A P
AP
McMahon
B J
BJ
Harpster
A
A
Bulkow
L R
LR
Heyward
W L
WL
Murray
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000413:Alaska / Q000453:epidemiology; D002277:Carcinoma / Q000208:ethnology*; D006528:Carcinoma, Hepatocellular / Q000208:ethnology*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D006509:Hepatitis B / Q000208:ethnology; D006801:Humans; D015994:Incidence; D007198:Indians, North American; D004930:Inuit; D008297:Male; D008875:Middle Aged; D010375:Pedigree