title: Long-term efficacy and safety of a low molecular weight heparin in chronic hemodialysis patients. A comparison with standard heparin.
abstract: The efficacy and safety of a low molecular weight heparin (LMWH) given as a single predialysis bolus injection was compared to standard heparin (SH) administered with a continuous infusion in a randomized, 6 month, open follow-up study in 70 patients undergoing hemodialysis. No major bleeding or adverse events were encountered during a total of 4,000 dialysis procedures (2,000 with LMWH). Clot formation in the extracorporeal circuit was minimal and comparable between the groups at 4, 13, and 26 weeks after the start of the study. No accumulation of LMWH anticoagulant activity was noted. It is concluded that the use of LMWH is a safe, effective, and less complex alternative to SH.
authors.affiliation: Center for Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: M T
authors.initials: MT
authors.lastname: Nurmohamed
authors.forename: J
authors.initials: J
authors.lastname: ten Cate
authors.forename: P
authors.initials: P
authors.lastname: Stevens
authors.forename: J A
authors.initials: JA
authors.lastname: Hoek
authors.forename: R L
authors.initials: RL
authors.lastname: Lins
authors.forename: J W
authors.initials: JW
authors.lastname: ten Cate
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008134:Long-Term Care; D011292:Premedication; D006435:Renal Dialysis
chemical_list: D006495:Heparin, Low-Molecular-Weight; D006493:Heparin