title: Effects of alprazolam on T-cell immunosuppressive response to surgical stress in mice.
abstract: Mice submitted to surgical stress induced by laparotomy and treated with chronic alprazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, as well as in peripheral T lymphocyte population. The blastic response of spleen lymphoid cells was also assessed and found to partially supress the inhibitory effect of surgery.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, University of Santiago de Compostela, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Freire-Garabal
authors.forename: A
authors.initials: A
authors.lastname: Belmonte
authors.forename: F
authors.initials: F
authors.lastname: Orallo
authors.forename: J
authors.initials: J
authors.lastname: Couceiro
authors.forename: M J
authors.initials: MJ
authors.lastname: Núñez
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000525:Alprazolam / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001772:Blood Cell Count; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013312:Stress, Physiological / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
chemical_list: D000324:Adrenocorticotropic Hormone; D000525:Alprazolam