title: Serine/threonine phosphatases in the nervous system.
abstract: The cloning and sequence determination of cDNAs encoding different types of serine/threonine protein phosphatases has provided a molecular basis for the protein phosphatase classification proposed by Ingebritsen and Cohen. Each of the phosphatases, phosphatase-1, -2A, -2B and -2C, exists as multiple isozymes raising the possibility that isozymes selectively expressed in different tissues may perform specific functions. The recent discovery of potent toxin inhibitors specific for protein phosphatase-1 and -2A will undoubtedly play an important role in the elucidation of the role of these enzymes in neuronal function.
authors.affiliation: Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
authors.forename: P
authors.initials: P
authors.lastname: Stemmer
authors.forename: C B
authors.initials: CB
authors.lastname: Klee
mesh_terms: D000818:Animals; D006801:Humans; D009420:Nervous System / Q000201:enzymology*; D009424:Nervous System Physiological Phenomena; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D054645:Protein Phosphatase 1; D012694:Serine / Q000378:metabolism*; D013912:Threonine / Q000378:metabolism*
chemical_list: D013912:Threonine; D012694:Serine; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1