title: Antibody response of captive cheetahs to modified-live feline virus vaccine.
abstract: The antibody response of cheetahs (Acinonyx jubatus) to modified live virus vaccine against feline panleukopenia (FPLV), herpes (FHV) and calici (FCV) viruses was assessed by means of an enzyme-linked immunosorbent assay (ELISA). In the first year of study, 82 cheetahs were bled pre-vaccination. Of these, antibody levels to FPLV were found in 100% of the animals. Only 54% were found to have antibodies to FHV and 99% had antibodies to FCV. One month after booster vaccination with the same vaccine, increased antibodies to FPLV, FHV and FCV were seen in 19 (58%), 18 (55%) and 25 (76%) of these animals, respectively (n = 33). In the second year of study, 65 cheetahs were bled pre-vaccination. Fifty three of these animals were negative for antibodies to FPLV while 28 were positive for FHV and 64 were positive for FCV. These animals were then bled 1, 2 and 6 mo post booster vaccination. The antibody levels to the various viruses showed different trends with time.
authors.affiliation: Department of Infectious Diseases, Faculty of Veterinary Science, University of Pretoria, Republic of South Africa.
authors.forename: J A
authors.initials: JA
authors.lastname: Spencer
authors.forename: R
authors.initials: R
authors.lastname: Burroughs
mesh_terms: D002612:Acinonyx; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D002139:Caliciviridae / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D028301:Feline Panleukopenia Virus / Q000276:immunology; D006564:Herpesviridae / Q000276:immunology; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines