title: Functional metabolic heart impairment after acute lethal hemorrhage followed by resuscitation.
abstract: Effects of acute lethal blood loss on postresuscitation heart impairment has been studied. Experiments were performed in mongrel male rats anesthesized with sodium pentobarbital (25 mg/kg). Functional metabolic heart impairments have been evaluated in different terms after resuscitation by isolated perfused heart method (Fallen et al., J. Appl. Physiol, 22 (1967) 836-839). It has been established that maximal heart injury occurs in the first hours after resuscitation. It is supported by the following findings: depression of myocardium contractile function grew; enzyme excretion from cardiomyocytes in coronary flow increased: efficacy of glucose utilization by means of carried function decreased; pyruvate excretion in coronary flow elevated. Because of severe course of postresuscitation period functional metabolic heart disturbances are more pronounced and preserved for a long time.
authors.affiliation: Division of Pathophysiology, Medical Institute, Omsk, U.S.S.R.
authors.forename: V T
authors.initials: VT
authors.lastname: Dolgikh
authors.forename: P Z
authors.initials: PZ
authors.lastname: Meerson
authors.forename: E M
authors.initials: EM
authors.lastname: Merginsky
authors.forename: V V
authors.initials: VV
authors.lastname: Rusakov
authors.forename: O V
authors.initials: OV
authors.lastname: Korpacheva
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000378:metabolism*
chemical_list: D011773:Pyruvates; D019289:Pyruvic Acid; D005947:Glucose