Immunologic aspects of pneumoconiosis.
This review summarizes recent research bearing on the role played by cells of the immune system in the development of pneumoconiosis. Findings related to the cellular and humoral immune responses to silica and asbestos are highlighted. Experimental results from humans and animal models are integrated into our current understandings of cellular and cytokine-mediated pathways leading to the generation of immune responses that may contribute to fibrogenesis and fibrosis. Potential mechanisms leading to the generation of an immune response by particulates are discussed, together with the indirect effects of particulates on fibroblasts by way of the cytokine network in the lung. Finally, suggestions are given for future research to help further elucidate the relationships between the cellular components of the immune system of the lung and the fibroblast that lead to fibrosis.
Scheule
R K
RK
Department of Pharmacology, University of Texas Medical School, Houston 77030.
Holian
A
A
D000818:Animals; D000917:Antibody Formation; D001194:Asbestos / Q000276:immunology; D005355:Fibrosis; D006801:Humans; D007107:Immune System / Q000502:physiology; D008168:Lung / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology; D010587:Phagocytosis; D011009:Pneumoconiosis / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D012822:Silicon Dioxide / Q000276:immunology
D001194:Asbestos; D012822:Silicon Dioxide