The effect of lithium chloride treatment on cell-mediated immunity in mice.
The immunomodulatory effect of lithium chloride (LiCl) administered i.p. to adult mice (150 mg/kg/day) on cellular immunity in vivo was investigated. A short (6-day) treatment with LiCl of either spleen cell donors in semiallogeneic or xenogeneic GVH reaction, or recipients in semiallogeneic HVG reaction, significantly diminished the early sings of local cell-mediated immunity. A short-term LiCl treatment of donor mice also abrogated systemic GVH reaction in newborn F1 recipients, while a treatment prolonged for 20 days did not alter the high GVH response of spleen cells typical for untreated donors. Thus, a striking time-dependent efficacy of LiCl on the reduction of GVH reaction was found.
Bubak-Satora
M
M
Department of Immunobiology, Polish Academy of Sciences, Kraków.
Skowron-Cendrzak
A
A
Kubera
M
M
D000818:Animals; D002712:Chlorides / Q000494:pharmacology*; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects*; D008094:Lithium / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride