Erythrocyte fructose 2,6-bisphosphate content in congenital hemolytic anemias.
We have investigated the levels of fructose 2,6-bisphosphate and its synthesizing enzyme 6-phosphofructo-2-kinase in red blood cells from different congenital anemias. Fructose 2,6-bisphosphate concentration and 6-phosphofructo-2-kinase activity are markedly influenced by the number of reticulocytes in all the cases studied with the exception of homozygous pyruvate kinase deficiency, where no correlation was observed with the percentage of reticulocytes.
Colomer
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Haematology Laboratory Department, Hospital Clinic i Provinicial, University of Barcelona, Catalonia, Spain.
Pujades
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A
Carballo
E
E
Vives Corrons
J L
JL
D000745:Anemia, Hemolytic, Congenital / Q000097:blood* / Q000201:enzymology; D000755:Anemia, Sickle Cell / Q000097:blood / Q000201:enzymology; D004912:Erythrocytes / Q000737:chemistry* / Q000201:enzymology; D005635:Fructosediphosphates / Q000097:blood*; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood; D006019:Glycolysis; D006593:Hexokinase / Q000097:blood; D006801:Humans; D025481:Phosphofructokinase-2; D010770:Phosphotransferases / Q000097:blood; D011770:Pyruvate Kinase / Q000172:deficiency; D012156:Reticulocytes / Q000737:chemistry / Q000201:enzymology; D013103:Spherocytosis, Hereditary / Q000097:blood / Q000201:enzymology; D013789:Thalassemia / Q000097:blood
D005635:Fructosediphosphates; C027652:fructose 2,6-diphosphate; D005954:Glucosephosphate Dehydrogenase; D010770:Phosphotransferases; D006593:Hexokinase; D025481:Phosphofructokinase-2; D011770:Pyruvate Kinase