title: The origin of extragonadal teratoma: case report of an immature teratoma occurring in a prenatal brain.
abstract: We describe a massive congenital intracranial teratoma (MCIT), which had a normal chromosome banding pattern 46,XY karyotype and a normal diploid DNA histogram, and which produced a variety of carcinoembryonic antigens. The volume density of primitive neural components (primitive neural tubes, small undifferentiated neuroepithelial cells, immature glial fibers and pigment cell components without neurofibrillar differentiation) was estimated to be 45%. We discuss the histogenesis, pathobiology and cell cycle kinetics.
authors.affiliation: Department of Pathology, Ohtsu Red Cross Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Saiga
authors.forename: H
authors.initials: H
authors.lastname: Osasa
authors.forename: H
authors.initials: H
authors.lastname: Hatayama
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: H
authors.initials: H
authors.lastname: Ono
authors.forename: T
authors.initials: T
authors.lastname: Mikami
mesh_terms: D000328:Adult; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000032:analysis; D001921:Brain / Q000196:embryology; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002455:Cell Division; D002871:Chromosome Banding; D004273:DNA, Neoplasm / Q000032:analysis; D003893:Desmin / Q000032:analysis; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007621:Karyotyping; D009380:Neoplasms, Nerve Tissue / Q000235:genetics / Q000473:pathology*; D016900:Neurofilament Proteins / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011247:Pregnancy; D013724:Teratoma / Q000235:genetics / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D002272:Carcinoembryonic Antigen; D004273:DNA, Neoplasm; D003893:Desmin; D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase