[Coxsackie B virus in children with acute myocarditis].
OBJECTIVE
To study etiopathogenic and follow-up aspects of patients with myocarditis.


METHODS
Among 44 cases of acute myocarditis in children studied from clinical and virological point of view, it was selected 16 which were positive to coxsackie B virus. The clinical investigation included blood test to enzyme dosage, chest X-ray, electro and echocardiogram. The virological work up to coxsackie B1, B3, B4, B5 and B6 included culture neutralization test and IgM (indirect immunofluorescence).


RESULTS
The positive results were: B4 in 9 (57%); B5 in 4 (25%), B1 in 2 (12%) and B3 in 1 (6%). It was not used immunosuppressive treatment. The follow-up (at least one year it was: 7 patients became free of symptoms (43%); 4 (25%) turned to be chronic dilated myocardiopathy 1 (6%) died and 4 (25%) were discharged from hospital but did not return to out-patient clinic. One of patients of chronic group during 4 years of follow-up had ventricular extrasystoles, second degree heart block and now is asymptomatic.


CONCLUSIONS
We did not observe significative differences among the several types of coxsackie B related to clinical course.
Herdy
G V
GV
Hospital Universitário António Pedro (HUAP), Departamento de Virologia da UFRJ.
al Odeh
C S
CS
Cunha
J de O
Jde O
Amorim
A M
AM
Ono
I de C
Ide C
D000208:Acute Disease; D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003384:Coxsackievirus Infections / Q000150:complications*; D004452:Echocardiography; D029822:Enterovirus B, Human / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009205:Myocarditis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011446:Prospective Studies
D000914:Antibodies, Viral
Virus Coxsackie B em crianças com miocardite aguda.