Expression of the homeobox Hox-4 genes and the specification of position in chick wing development.
The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.
Izpisúa-Belmonte
J C
JC
European Molecular Biology Laboratory, Heidelberg, Germany.
Tickle
C
C
Dollé
P
P
Wolpert
L
L
Duboule
D
D
D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D003001:Cloning, Molecular; D005121:Extremities / Q000196:embryology; D015870:Gene Expression / Q000187:drug effects; D015723:Gene Library; D005801:Genes, Homeobox; D051379:Mice; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D014212:Tretinoin / Q000494:pharmacology; D014921:Wings, Animal / Q000196:embryology
D014212:Tretinoin