title: A kappa opiate agonist, U50,488H, enhances energy expenditure in rats.
abstract: The effect of U50,488H (a selective kappa opiate agonist) on oxygen consumption was measured in either resting and free-moving rats. In both states, U50,488H provokes an increase in oxygen consumption. In resting rats, the increase occurs at lower doses than in free-moving rats. The explanation could be that in the free-moving rats the drug results in an increase in energy expenditure, partially compensated by a decrease in activity.
authors.affiliation: Laboratoire de Nutrition Humaine, INSERM U 286, Faculté X. Bichat, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Mandenoff
authors.forename: J A
authors.initials: JA
authors.lastname: Seyrig
authors.forename: D
authors.initials: D
authors.lastname: Betoulle
authors.forename: L
authors.initials: L
authors.lastname: Brigant
authors.forename: J C
authors.initials: JC
authors.lastname: Melchior
authors.forename: M
authors.initials: M
authors.lastname: Apfelbaum
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D017473:Receptors, Opioid, kappa
chemical_list: D000700:Analgesics; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017473:Receptors, Opioid, kappa; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer