[The effect of different temperature regimens in reperfusion on the recovery of myocardial contractile function after hypothermic cardiac ischemia].
The changes of the contractile function of the heart and cAMP content in myocardium depending on the temperature conditions of reperfusion (28 degrees C, 32 degrees C, 37 degrees C) after 90 minutes of hypothermal ischemia have been investigated on isolated hearts of rats. The comparative analysis of the investigation results has shown that, after cooling a cardial muscle to 8-12 degrees C, reperfusion with initial temperature of perfusate of 32 degrees C promotes fast restoration of independent cardiac activity, does not cause formation of reperfusion contracture, normalizes processes of synthesis and cAMP utilization in cardiomyocytes.
Boiarinov
G A
GA
Gorokh
O V
OV
Balandina
M V
MV
Mukhina
I V
IV
D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D007036:Hypothermia, Induced; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D015425:Myocardial Reperfusion / Q000379:methods*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013696:Temperature; D013997:Time Factors
D000242:Cyclic AMP
Vliianie razlichnykh temperaturnykh rezhimov reperfuzii na vosstanovlenie sokratitel'noĭ funktsii miokarda posle gipotermicheskoĭ ishemii serdtsa.