Fast feedback regulation of ACTH by cortisol.
1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.
Krishnan
K R
KR
Department of Psychiatry, Duke University Medical Center, Durham, NC.
Ritchie
J C
JC
Manepalli
A N
AN
Saunders
W
W
Li
S W
SW
Venkataraman
S
S
Nemeroff
C B
CB
Carroll
B J
BJ
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D005246:Feedback; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male
D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone