Platelet [3H]-imipramine binding and leukoencephalopathy in geriatric depression.
We examined the relationship between platelet [3H]-imipramine binding and leukoencephalopathy as assessed by 1.5 Tesla Magnetic Resonance Imaging (MRI) in 21 elderly depressed patients who satisfied DSM-III criteria for major depression. Both drug-free platelet [3H]-imipramine binding and brain MRI studies were obtained during the same episode of depression. Our findings show a significant inverse relationship between frequency of subcortical hyperintensity (SCH) and the number (Bmax) of platelet [3H]-imipramine binding sites. Patients with Bmax less than 850 fmol/mg protein had significantly larger SCH compared with patients with a higher Bmax. These data provide further support to the potential use of platelet [3H]-imipramine binding studies and brain MR imaging as diagnostic adjuncts in geriatric depression and suggest, moreover, that these two biological markers may be linked in geriatric patients with depression.
Husain
M M
MM
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710.
Knight
D L
DL
Doraiswamy
P M
PM
Figiel
G S
GS
McDonald
W M
WM
Boyko
O B
OB
Krishnan
K R
KR
Nemeroff
C B
CB
D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism*; D001921:Brain / Q000473:pathology; D002352:Carrier Proteins; D003704:Dementia / Q000097:blood / Q000175:diagnosis*; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000097:blood / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine