title: Complete reversion of the abo phenotype in D. melanogaster occurs only when the blood transposon is lost from region 32E.
abstract: The abnormal oocyte phenotype is characterized by instability, as shown by the loss and reappearance of the abo maternal effect under specific genetic conditions. Our previous finding that a correlation exists between the abo phenotype and the presence of a blood transposon in region 32E, led us to perform an extensive genetic and molecular analysis of the most significant aspects of the abo phenotype in different genetic backgrounds. The results of these experiments can be summarized as follows: Complete reversion occurs only when the blood trnasposon is lost, thus definitively demonstrating that the insertion of the blood transposon in region 32E is the molecular event that causes the pleiotropic abo phenotype. Partial reversion can also occur without loss of the transposon indicating that different molecular pathways may be involved in the loss of the abo phenotype. Reappearance of the full abo phenotype can occur only in heterozygous lines constructed from partially revertant abo homozygous lines that have not lost the blood transposon.
authors.affiliation: Istituto Internazionale di Genetica e Biofisca, CNR, Naples, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Cavaliere
authors.forename: F
authors.initials: F
authors.lastname: Graziani
authors.forename: S
authors.initials: S
authors.lastname: Andone
authors.forename: A
authors.initials: A
authors.lastname: Manzi
authors.forename: C
authors.initials: C
authors.lastname: Malva
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements; D004331:Drosophila melanogaster / Q000235:genetics* / Q000502:physiology; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D008297:Male; D009154:Mutation; D009865:Oocytes / Q000502:physiology; D010641:Phenotype
chemical_list: D004251:DNA Transposable Elements