[Changes in the synaptic release of catecholamines in the rat striatum with multiple microinjections into it of fenamine and haloperidol].
The dopamine (DA) and noradrenaline (NA) levels of the synapses of the rat rostral striatum was studied with the aid of radioenzymatic and microdialysis techniques. Two weeks after the starting of 45 g amphetamine daily intrastriatal microinjections, the level of DA was 3-5-fold higher than in the control whereas NA level still was unchanged. The next amphetamine injection did not potentiate the synaptic DA level whereas NA level was increased. In contrast to behavioral deviation (the avoidance conditioning lost), the haloperidol intrastriatal microinjections did not affect the DA synaptic level in rostral neostriatum.
Iakimovskiĭ
A F
AF
Saul'skaia
N B
NB
D000661:Amphetamine / Q000008:administration & dosage*; D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004347:Drug Interactions; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D006220:Haloperidol / Q000008:administration & dosage*; D008297:Male; D008845:Microinjections; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013569:Synapses / Q000187:drug effects* / Q000378:metabolism
D002395:Catecholamines; D000661:Amphetamine; D006220:Haloperidol; D004298:Dopamine; D009638:Norepinephrine
Izmenenie sinapticheskogo vybrosa katekholaminov striatuma krys pri mnogokratnykh mikroin''ektsiiakh v nego fenamina i galoperidola.