Abnormalities in calcium metabolism in sarcoidosis.
In sarcoidosis the excess of calcitriol of extrarenal origin induces changes in calcium metabolism (CM), specifically hypercalciuria and less often hypercalcemia. We report the results of the study of CM in 44 sarcoidosis patients (mean age 43.7 +/- 11 years, M +/- SD, 21 males). 25% were on steroid therapy at the time of the tests. 34% of the patients had hypercalciuria, this figure rose to 39% if only untreated patients were considered. Hypercalcemia was found in only 2.2%. Chronic forms and extrathoracic involvement (mostly skin) were more frequent in the hypercalciuric patients than in the normocalciuric.
Rottoli
P
P
Institutes of Respiratory Diseases and Internal Medicine, Univ. of Siena, Italy.
Rottoli
L
L
Gommelli
S
S
Zacchei
F
F
Coviello
G
G
Piccolo
L
L
Panzardi
G
G
Solitro
S
S
Gennari
C
C
Vagliasindi
M
M
D000328:Adult; D002117:Calcitriol / Q000378:metabolism; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000378:metabolism*
D002117:Calcitriol; D002118:Calcium