title: Adamantinoma of the tibia with pulmonary metastases and hypercalcemia.
abstract: Adamantinomas of long bones are rare primary malignant bone tumors. A case of a woman who died of pulmonary metastases of an adamantinoma of the tibia is presented. A unique feature of this case is the association with hypercalcemia. The association of hypercalcemia, hypophosphatemia, decreased parathyroid hormone levels and increased urinary cAMP excretion suggests a humorally mediated hypercalcemia. Histologic and ultrastructural analysis of the pulmonary metastases demonstrated that the tumor was composed of a heterogeneous cell population with mesenchymal and epithelial differentiation.
authors.affiliation: Department of Respiratory Diseases, University Hospital, Ghent, Belgium.
authors.forename: J X
authors.initials: JX
authors.lastname: Van Schoor
authors.forename: J H
authors.initials: JH
authors.lastname: Vallaeys
authors.forename: G F
authors.initials: GF
authors.lastname: Joos
authors.forename: H J
authors.initials: HJ
authors.lastname: Roels
authors.forename: R A
authors.initials: RA
authors.lastname: Pauwels
authors.forename: M E
authors.initials: ME
authors.lastname: Van Der Straeten
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology*; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D010710:Phosphates / Q000097:blood; D011859:Radiography
chemical_list: D010710:Phosphates; D000242:Cyclic AMP