title: Liquid-liquid extraction systems for THC-COOH and benzoylecgonine.
abstract: Because DuPont Instruments has discontinued commercial availability of the PREP automated sample processor, an alternate method for the general extraction of THC-COOH and benzoylecgonine from a urine matrix in the military drug screening laboratories' standard procedure is needed. The liquid-liquid extraction method presented for isolation of THC-COOH uses extraction with isobutanol-hexane followed by back extraction into an aqueous alkaline medium and results in a percent recovery of 104.24 +/- 9.71%. The isolation of benzoylecgonine involves extraction into ethanol-methylene chloride followed by evaporation and derivatization with 1-iodopropane; recovery is 102.43 +/- 3.13%.
authors.affiliation: Navy Drug Screening Laboratory, Great Lakes, Illinois 60088.
authors.forename: S B
authors.initials: SB
authors.lastname: Needleman
authors.forename: K
authors.initials: K
authors.lastname: Goodin
authors.forename: W
authors.initials: W
authors.lastname: Severino
mesh_terms: D003042:Cocaine / Q000031:analogs & derivatives* / Q000652:urine; D013759:Dronabinol / Q000652:urine*; D006801:Humans; D015813:Substance Abuse Detection
chemical_list: C005618:benzoylecgonine; D013759:Dronabinol; D003042:Cocaine