Effect of cisplatin, rIFN-Y, LPS and MDP on release of H2O2, O2- and lysozyme from human monocytes in vitro.
Increased secretion of H2O2, O2- and lysozyme by human monocytes in vitro on treatment with cisplatin, rIFN-Y (interferon-Y), LPS (lipopolysaccharide) and MDP (muramyl dipeptide) is reported. It is suggested that increased production of these secretory products represent the activated state of monocytes. These in vitro activated monocytes could either kill the tumor cells via increased contact mediated cytolysis or cytolysis mediated via the release of the secretory products like H2O2, O2- and lysozyme.
Pai
K
K
Department of Zoology, School of Biotechnology, Banaras Hindu University, Varanasi, India.
Sodhi
A
A
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology*; D003574:Cytochrome c Group / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000494:pharmacology*; D008070:Lipopolysaccharides; D008247:Lysosomes / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects*; D009113:Muramidase / Q000378:metabolism; D010545:Peroxides; D011994:Recombinant Proteins / Q000494:pharmacology; D013997:Time Factors
D003574:Cytochrome c Group; D008070:Lipopolysaccharides; D010545:Peroxides; D011994:Recombinant Proteins; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D007371:Interferon-gamma; D006861:Hydrogen Peroxide; D009113:Muramidase; D002945:Cisplatin