N-methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 blocks non-opioid stress-induced analgesia. I. Comparison of opiate receptor-deficient and opiate receptor-rich strains of mice.
The effects of the specific N-methyl-D-aspartic acid (NMDA) receptor antagonist MK-801 (0.075 mg/kg), and the specific opiate receptor antagonist naloxone (10 mg/kg), on swim stress-induced analgesia (SSIA) were studied in opiate receptor-deficient (CXBK) and opiate receptor-rich (CXBH) mice. Animals were subjected to forced swimming, and analgesia was assessed using the hot-plate test. In CXBK mice SSIA was blocked by MK-801 but was completely insensitive to naloxone. In CXBH mice SSIA was partially attenuated both by naloxone and MK-801, and it was nearly abolished by a combination of these drugs. Morphine analgesia (10 mg/kg) was abolished by naloxone but completely unaffected by MK-801 in CXBH mice. These findings suggest that the NMDA receptor is critically involved in the non-opioid component of SSIA.
Marek
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Department of Psychology, University of California, Los Angeles 90024.
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Ben-Eliyahu
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Liebeskind
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D000704:Analysis of Variance; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D010146:Pain / Q000503:physiopathology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D011957:Receptors, Opioid / Q000235:genetics / Q000502:physiology*; D012684:Sensory Thresholds / Q000187:drug effects*; D013312:Stress, Physiological / Q000503:physiopathology*
D016194:Receptors, N-Methyl-D-Aspartate; D011957:Receptors, Opioid; D016291:Dizocilpine Maleate