Mechanism of action of arginine vasopressin on acute ischemic brain edema.
The purpose of this experiment is to study the role of arginine vasopressin (AVP) in acute cerebral ischemic edema in Mongolian gerbils. The results show that intracerebroventricular injection (ICV) of AVP exacerbates acute ischemic brain edema, while ICV of AVP antiserum significantly decreases the ischemic brain edema. Nimodipine (calcium antagonist) cannot block this role of AVP in brain edema. In addition, the cortical Na(+)-K+ ATPase activity is significantly decreased, while the cAMP content of ischemic cortex and hypothalamus and the cGMP content of the hypothalamus are markedly increased after AVP ICV. These suggest that AVP may play an important role in the pathophysiologic process of ischemic brain edema by inhibiting the Na(+)-K+ ATPase activity of the cerebral cell membrane and the AVP receptors mediated by cAMP and cGMP.
Liu
X F
XF
Department of Neurology, Changhai Hospital, Second Military Medical College, Shanghai.
Shi
Y M
YM
Lin
B C
BC
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D001929:Brain Edema / Q000209:etiology* / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D005260:Female; D005849:Gerbillinae; D007276:Injections, Intraventricular; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D001127:Arginine Vasopressin; D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D006152:Cyclic GMP