title: [The prevalence of serum anti-hepatitis C virus antibodies in hemodialyzed patients].
abstract: Hepatitis C virus (HCV) is responsible for a high percentage of cases of transfusional hepatitis and is often considered the etiological agent of numerous cases of non-A, non-B hepatitis in which parenteral transmission has not been documented. Patients undergoing hemodialysis are at risk for HCV infection. We used an immunoenzymatic method and confirmatory test (neutralization test) to determine serum anti-HCV antibody positivity in order to identify the factors associated with increased risk of HCV infection. We studied 63 hemodialyzed patients from eastern Sicily and compared the mean dialytic age and transfusion case history in positive and negative groups. 17.4 percent of the patients were anti-HCV positive. Mean dialytic age was significantly higher in the anti-HCV positive group. On the contrary no significant differences regarding transfusion case history or number of units of blood transfused were seen in the two groups. Our study confirms that hemodialyzed patients are at risk for HCV infection. This risk seems to increase with dialytic age. The lack of correlation between HCV and transfusion case history suggests that it may be a hospital-acquired infection.
authors.affiliation: Cattedra di Nefrologia Chirurgica, Università degli Studi di Catania.
authors.forename: M
authors.initials: M
authors.lastname: Motta
authors.forename: R
authors.initials: R
authors.lastname: Brischetto
authors.forename: F
authors.initials: F
authors.lastname: Rapisarda
authors.forename: C
authors.initials: C
authors.lastname: Corno
authors.forename: C
authors.initials: C
authors.lastname: Rapisarda
authors.forename: P
authors.initials: P
authors.lastname: Fatuzzo
authors.forename: A
authors.initials: A
authors.lastname: Messina
authors.forename: A
authors.initials: A
authors.lastname: Biondi
authors.forename: E
authors.initials: E
authors.lastname: Mezzasalma
authors.forename: G
authors.initials: G
authors.lastname: Calcara
mesh_terms: D000367:Age Factors; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D008297:Male; D015995:Prevalence; D006435:Renal Dialysis; D012307:Risk Factors; D012802:Sicily / Q000453:epidemiology
chemical_list: D006508:Hepatitis Antibodies
vernacular_title: Prevalenza degli anticorpi sierici anti-virus dell'epatite C in pazienti emodializzati.