title: Incidence of hepatitis C virus infection in burn patients: detection of anti-C100, anti-C33c and anti-Core antibodies.
abstract: Anti-hepatitis C virus antibodies were searched for in 45 burnt patients, at the time of burn injury and more than 6 months after burn injury. HCV infection was detected in 18% as a consequence of the numerous transfusions of blood or blood derivatives used during the post-burn treatment. Five patients displayed evidence of anti-C100, anti-C33c and anti-Core antibodies together; two patients had only anti-C100 and anti-C33c antibodies, and the last one showed only anti-Core antibodies. Chronic hepatitis was observed in 83% of HCV infections. Kinetics of appearance of anti-HCV antibodies varied between patients. Anti-Core is generally the first to be detected at high levels; however, in at least one case it was detected only two and a half months after C100 and C33c antibodies.
authors.affiliation: Institut de Virologie de Tours, Faculté de Pharmacie, France.
authors.forename: P
authors.initials: P
authors.lastname: Coursaget
authors.forename: G
authors.initials: G
authors.lastname: Lesage
authors.forename: B
authors.initials: B
authors.lastname: Simpson
authors.forename: V
authors.initials: V
authors.lastname: Mayelo
authors.forename: P
authors.initials: P
authors.lastname: Le Cann
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D002056:Burns / Q000150:complications* / Q000276:immunology; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D065227:Transfusion Reaction
chemical_list: D006508:Hepatitis Antibodies; D000410:Alanine Transaminase