title: [Pain and painkillers. 1. Neurophysiologic component].
abstract: A pain impulse is transmitted in the thin nerves from nerve cell to nerve cell, by means of neurotransmitters and -modulators, shed in the synapses. In the dorsal horn of the spinal medulla the impulse is either or not allowed to travel to the brain by a 'gate control' mechanism, and pain may be felt. The gate is influenced by cells in the nearby situated substantia gelatinosa, thick nerves and efferent nerves from higher situated centra.
authors.affiliation: Academisch Centrum Tandheelkunde Amsterdam (ACTA).
authors.forename: A H
authors.initials: AH
authors.lastname: Schuurs
authors.forename: J A
authors.initials: JA
authors.lastname: Baart
authors.forename: M P
authors.initials: MP
authors.lastname: Duyx
mesh_terms: D000700:Analgesics; D006801:Humans; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology*; D009435:Synaptic Transmission
chemical_list: D000700:Analgesics
vernacular_title: Pijn en pijnstiller. I. Neurofysiologische component.