title: The synthesis and antiviral activity of some 4'-thio-2'-deoxynucleoside analogues.
abstract: A practical 7-step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides. These novel nucleoside analogues have potentially useful biological activity and are resistant to phosphorolysis.
authors.affiliation: School of Chemistry, University of Birmingham, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Dyson
authors.forename: P L
authors.initials: PL
authors.lastname: Coe
authors.forename: R T
authors.initials: RT
authors.lastname: Walker
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003853:Deoxyribonucleosides / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014709:Vero Cells; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003853:Deoxyribonucleosides; D013872:Thionucleosides