Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents.
Townsend
L B
LB
Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor.
Drach
J C
JC
Wotring
L L
LL
Vittori
S
S
Pudlo
J S
JS
Swayze
E E
EE
Gupta
P
P
Maruyama
T
T
Saxena
N
N
Coleman
L A
LA
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D051379:Mice; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D010948:Viral Plaque Assay
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides; D011758:Pyrroles