[Studies on collagenase inhibitors. III. Inhibitory effects of anthracyclines on bacterial collagenase].
Inhibitory effects of anthracyclines on bacterial collagenase were examined. Daunomycin, doxorubicin, and aclarubicin potently inhibited the collagenase, but mitomycin C and 5-fluorouracil did not inhibit. Inhibitory activities of anthracyclines were constant regardless of the concentrations of Ca2+, activator of collagenase, or of Zn2+, active center of collagenase. These results suggest that the inhibitory mechanisms of anthracyclines were independent of a chelate effect on Ca2+ or Zn2+.
Tanaka
T
T
Department of Pharmacology, Kohno Clinical Medicine Research Institute, Tokyo, Japan.
Metori
K
K
Mineo
S
S
Matsumoto
H
H
Satoh
T
T
D015250:Aclarubicin / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001419:Bacteria / Q000201:enzymology*; D003630:Daunorubicin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D003012:Microbial Collagenase / Q000037:antagonists & inhibitors*
D000903:Antibiotics, Antineoplastic; D015250:Aclarubicin; D004317:Doxorubicin; D003012:Microbial Collagenase; D003630:Daunorubicin