Spontaneous lymphocyte proliferation in HTLV-II infection.
We measured lymphocyte proliferation in the absence of antigenic stimulation in 45 HTLV-II infected, 9 HTLV-I infected, and 19 HTLV-I seronegative intravenous drug users (IVDU). Lymphocyte proliferation was higher in IVDUs infected with HTLV-II than in seronegative IVDUs but lower than among those infected with HTLV-I. Higher rates of proliferation were also associated with needle sharing, CD4+ and IL2R+ lymphocyte counts, and HTLV-I antibody titres.
Wiktor
S Z
SZ
Viral Epidemiology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Jacobson
S
S
Weiss
S H
SH
Shaw
G M
GM
Reuben
J S
JS
Shorty
V J
VJ
McFarlin
D E
DE
Blattner
W A
WA
D000328:Adult; D044383:Black People; D003937:Diagnosis, Differential; D005260:Female; D015490:HTLV-I Infections / Q000097:blood / Q000175:diagnosis; D015491:HTLV-II Infections / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*; D008297:Male; D016133:Polymerase Chain Reaction; D015819:Substance Abuse, Intravenous / Q000097:blood / Q000150:complications*