title: Lack of evidence for involvement of Epstein-Barr virus in the development of the "Quilty" lesion of transplanted hearts: an in situ hybridization study.
abstract: We investigated the possible relationship of Epstein-Barr virus to the development of subendocardial lymphocytic infiltrates. In situ hybridization for Epstein-Barr virus genomic sequences was performed in 22 heart biopsy specimens with subendocardial infiltrates for 19 heart transplant patients. Epstein-Barr virus genomic sequences were not detected in the lymphocytes or myocytes in any of the heart biopsy specimens. We conclude that Epstein-Barr virus is not related to the development of subendocardial lymphocytic infiltrates.
authors.affiliation: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
authors.forename: R E
authors.initials: RE
authors.lastname: Nakhleh
authors.forename: C M
authors.initials: CM
authors.lastname: Copenhaver
authors.forename: K
authors.initials: K
authors.lastname: Werdin
authors.forename: K
authors.initials: K
authors.lastname: McDonald
authors.forename: S H
authors.initials: SH
authors.lastname: Kubo
authors.forename: J G
authors.initials: JG
authors.lastname: Strickler
mesh_terms: D001706:Biopsy; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D016679:Genome, Viral; D016027:Heart Transplantation / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*
chemical_list: D015342:DNA Probes; D004279:DNA, Viral