In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh.
The design of a skin-substitute must address the need for a dermal component, as this mesenchymally-derived tissue is important in maintaining the integrity and function of skin. An in vivo study was undertaken to assess the use of two biodegradable meshes, polyglycolic acid and polyglactin-910, as carriers for cultured human fibroblasts in a living dermal replacement. The consistent vascularization and epithelialization of these grafts placed on athymic mice showed that this has potential in re-creating the dermis in a skin-substitute.
Cooper
M L
ML
Department of Surgery, University of California, San Diego Medical Center 92103.
Hansbrough
J F
JF
Spielvogel
R L
RL
Cohen
R
R
Bartel
R L
RL
Naughton
G
G
D000818:Animals; D001187:Artificial Organs; D001673:Biodegradation, Environmental; D001684:Biological Dressings; D002478:Cells, Cultured; D003094:Collagen / Q000032:analysis; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D011098:Polyglactin 910; D011100:Polyglycolic Acid; D013526:Surgical Mesh; D014945:Wound Healing / Q000502:physiology
D011100:Polyglycolic Acid; D011098:Polyglactin 910; D003094:Collagen