title: Conservation of the most JH proximal Ig VH gene segment (VHVI) throughout primate evolution.
abstract: The human VHVI gene segment, the sole member of the VHVI gene family, is remarkable in that it is the most D-proximal VH gene segment and is apparently nonpolymorphic. Here we report that the VHVI gene segment has been remarkably preserved in primate evolution. We were unable to detect RFLP among several primates, and nucleotide sequences of several VHVI gene segments showed remarkable conservation. No differences were detected in the nucleotide sequences of the VHVI gene segment from three unrelated chimpanzees. These findings suggest that the VHVI gene segment has been strongly selected for during primate evolution, suggesting an important immunologic role.
authors.affiliation: Department of Internal Medicine, University of Texas Health Science Center, Dallas 75235.
authors.forename: K
authors.initials: K
authors.lastname: Meek
authors.forename: T
authors.initials: T
authors.lastname: Eversole
authors.forename: J D
authors.initials: JD
authors.lastname: Capra
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D005803:Genes, Immunoglobulin; D006071:Gorilla gorilla / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D008252:Macaca fascicularis / Q000235:genetics; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry; D002679:Pan troglodytes / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D009841:Oligonucleotides