Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model.
Intraperitoneal superoxide dismutase (SOD) and catalase were used to block the toxic effects of superoxide anion (O2) and hydrogen peroxide (H2O2), associated with the production of endometriosis and inflammation in a rabbit model. In a two-part animal study, the combined instillation of SOD and catalase significantly reduced the formation of intraperitoneal adhesions at endometriosis sites.
Portz
D M
DM
University of Michigan Medical Center, Department of Obstetrics and Gynecology, Ann Arbor.
Elkins
T E
TE
White
R
R
Warren
J
J
Adadevoh
S
S
Randolph
J
J
D000818:Animals; D002374:Catalase / Q000008:administration & dosage*; D004715:Endometriosis / Q000150:complications / Q000378:metabolism; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010386:Pelvic Neoplasms / Q000150:complications / Q000378:metabolism; D010532:Peritoneal Diseases / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D011817:Rabbits; D013482:Superoxide Dismutase / Q000008:administration & dosage*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
D005609:Free Radicals; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen