Increased GABAergic transmission aggravates nucleus basalis magnocellularis lesion-induced behavioral deficits.
Quisqualic acid NBM lesions had no effect on water maze performance, but slightly impaired passive avoidance acquisition. GammavinylGABA treatment alone had no effect on the passive avoidance and water maze performance, but aggravated acquisition deficit in rats subjected to NBM lesioning. However, gammavinylGABA-treated NBM-lesioned rats reached control level of performance.
Riekkinen
P
P
Department of Neurology, University of Kuopio, Finland.
Sirviö
J
J
Jäkälä
P
P
Mazurkiewicz
M
M
Valjakka
A
A
Riekkinen
M
M
Riekkinen
P
P
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000614:Aminocaproates / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013377:Substantia Innominata / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D009435:Synaptic Transmission; D020888:Vigabatrin; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000614:Aminocaproates; D005680:gamma-Aminobutyric Acid; D016318:Quisqualic Acid; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin