[Effects of furyl-dihydropyridines I on lipid peroxides of ischemic myocardium and ATPases activity of erythrocyte membranes in rats].
Acute myocardial ischemia and reperfusion in rats increased glutamic oxalacetic transaminase (GOT), non-esterified fatty acid (FFA), malondialdehyde (MDA) content. Furyl-dihydropyridines I 10 mg.kg-1 decreased the release of GOT, FFA, MDA of ischemic myocardium, and prevent ischemia-reperfusion arrhythmia. Furyl-dihydropyridines I increased Na, K-ATPase activity and N-acethylneuraminic acid (NANA) content of erythrocyte membranes, inhibited Ca-ATPase activity of erythrocyte membranes in rats. The results suggested that the mechanism of protecting the ischemic-reperfused myocardium might be associated with the inhibition of cellular lipid peroxidation and Ca-ATPase activity of cell membranes.
Liu
D Q
DQ
Department of Pharmacology, Fourth Military Medical University, Xi-an, China.
Pang
Z Q
ZQ
Zhao
D H
DH
Sheng
B H
BH
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002121:Calcium Channel Blockers; D000252:Calcium-Transporting ATPases / Q000097:blood*; D004095:Dihydropyridines / Q000494:pharmacology* / Q000627:therapeutic use; D004910:Erythrocyte Membrane / Q000201:enzymology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D008315:Malondialdehyde / Q000097:blood*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood*
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D005230:Fatty Acids, Nonesterified; C071424:2,6-dimethyl-4-furyl-1,4-dihydropyridine-5-dicarboxylate; D008315:Malondialdehyde; D001219:Aspartate Aminotransferases; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase