Tumor cell autocrine motility factor receptor.
The ability to locomote and migrate is fundamental to the acquisition of invasive and metastatic properties by tumor cells. Autocrine motility factor (AMF) is a cytokine produced by various tumor cells which stimulates their in vitro motility and in vivo lung-colonizing ability. AMF stimulates cell motility via a receptor-mediated signalling pathway. Signal transduction following binding of AMF to its receptor, a cell surface glycoprotein of 78 kD (gp78), is mediated by a pertussis toxin sensitive G protein, inositol phosphate production and the phosphorylation of gp78. AMF induces gp78 internalization to intracellular tubulovesicles and transport to the leading edge stimulating pseudopodial protrusion and cell motility.
Nabi
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IR
Cancer Metastasis Program, Michigan Cancer Foundation, Detroit 48201.
Watanabe
H
H
Silletti
S
S
Raz
A
A
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D005956:Glucose-6-Phosphate Isomerase / Q000502:physiology*; D006801:Humans; D008546:Melanoma, Experimental / Q000503:physiopathology*; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*; D060285:Receptors, Autocrine Motility Factor; D011956:Receptors, Cell Surface / Q000502:physiology*; D018121:Receptors, Cytokine; D044767:Ubiquitin-Protein Ligases
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; C555000:AMFR protein, human; C555002:Amfr protein, mouse; D060285:Receptors, Autocrine Motility Factor; D044767:Ubiquitin-Protein Ligases; D005956:Glucose-6-Phosphate Isomerase