title: Muscle metabolism in older subjects using 31P magnetic resonance spectroscopy.
abstract: We used phosphorus magnetic resonance spectroscopy to study the calf muscles of elderly normal (mean +/- SD) (80.0 +/- 5.12 years), elderly impaired (80.7 +/- 0.58 years), old normal (66.8 +/- 1.92 years), and young normal people (24.6 +/- 4.72 years). Relative levels of inorganic phosphate (Pi), phosphocreatine (PCr), and adenosine triphosphate were measured with a 1.9-tesla, 30-cm bore magnet at rest and following plantra flexon exercise. No differences were found at rest or during recovery from exercise in the elderly normal subjects with respect to gender or the presence of stable medical problems treated with medication. At rest there was an age-related decrease in the ratio of PCr/Pi. After exercise, the time constant of PCr recovery increased with age. A mild 7-week exercise regimen consisting of plantar flexion had no effect on time constant of PCr recovery in the elderly subjects. Four elderly impaired subjects had lower PCr/Pi ratios at rest and slower time constant of PCr recovery after exercise than normal elderly subjects. We conclude that gender and the presence of stable medical problems had no effect on muscle metabolism in the elderly and that the elderly recovered slower than young controls. This slower recovery was not corrected with a mild exercise program.
authors.affiliation: Department of Biochemistry and Biophysics, Philadelphia Institute of Physical Therapy, University of Pennsylvania 19104.
authors.forename: K K
authors.initials: KK
authors.lastname: McCully
authors.forename: M A
authors.initials: MA
authors.lastname: Forciea
authors.forename: L M
authors.initials: LM
authors.lastname: Hack
authors.forename: E
authors.initials: E
authors.lastname: Donlon
authors.forename: R W
authors.initials: RW
authors.lastname: Wheatley
authors.forename: C A
authors.initials: CA
authors.lastname: Oatis
authors.forename: T
authors.initials: T
authors.lastname: Goldberg
authors.forename: B
authors.initials: B
authors.lastname: Chance
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009132:Muscles / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010759:Phosphorus Isotopes
chemical_list: D010710:Phosphates; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D010727:Phosphoric Diester Hydrolases