title: [Clinical and immunohistological findings of juvenile nasopharyngeal angiofibroma experienced in the last six years].
abstract: Five patients with juvenile nasopharyngeal angiofibroma were found between 1984 and 1990 in our department. Clinical findings, treatment, and postoperative follow-up were reported. Two patients belonged to stage III and remnant 3 patients belonged to stage I. In cases of stage I, a surgical approach through the suprahyoid pharyngotomy was a worthy procedure to try, because angiofibroma was observed under direct vision and hemostasis was easy. In therapeutic planning, the authors emphasized the need of a preoperative staging classification based on CT scanning and selective angiography. In immunohistochemical studies, Langerhans cells with S-100 protein positive were found. Fibroblasts revealed estradiol positive but testosterone showed negative in all cases. Thus, juvenile nasopharyngeal angiofibroma was considered to be neoplasm related estradiol.
authors.affiliation: Department of Otolaryngology, Nagasaki University.
authors.forename: H
authors.initials: H
authors.lastname: Kumagami
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: N
authors.initials: N
authors.lastname: Sakihama
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004958:Estradiol / Q000378:metabolism; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D013739:Testosterone; D004958:Estradiol; D010751:Phosphopyruvate Hydratase