title: Synthesis of [18F]flunarizine.
abstract: Flunarizine, a calcium channel antagonist of the piperazine class, has been labeled with the positron-emitter 18F.4-[18F]Fluoro-4-fluorobenzhydryl chloride was prepared in three steps from no-carrier-added [18F]fluoride ion, and used in the alkylation of N-cinnamylpiperazine to give [18F]flunarizine in 13% radiochemical yield (from [18F]fluoride).
authors.affiliation: Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor 48109.
authors.forename: M R
authors.initials: MR
authors.lastname: Kilbourn
mesh_terms: D005444:Flunarizine; D005462:Fluorine Radioisotopes; D015394:Molecular Structure
chemical_list: D005462:Fluorine Radioisotopes; D005444:Flunarizine