[Role of prostaglandins and the beta-adrenergic system in central and peripheral hyperkinesia in borderline hypertension].
The effects of short-term administration of indomethacin and propranolol were studied in two groups of patients with borderline hypertension and both central and peripheral hyperkinesia. Indomethacin and propranolol both significantly increased total peripheral resistance (respectively +32 +/- 3%, +59 +/- 7%, p less than 0.001). The increase in blood pressure after administrating propranolol was not significant (+3 +/- 2%), as opposed to what was obtained with indomethacin, (+5 +/- 2%, p less than 0.02). On the brachial artery, Indomethacin had no effect on blood flow and local resistance, on the other hand propranolol induced a decrease in blood flow in the brachial artery (-43 +/- 3%, p less than 0.001) and an elevation of local resistance (+105 +/- 18%, p less than 0.01). While central hyperkinesia depends on both prostaglandins and on the beta-adrenergic system, high muscle blood flow seems to be regulated by the beta-adrenergic system alone, without participation of prostaglandins.
Megnien
J L
JL
Centre de Médecine Préventive Cardio-Vasculaire, Hôpital Broussais, Paris.
Levenson
J
J
Simon
A
A
D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006948:Hyperkinesis / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology
D011453:Prostaglandins; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D007213:Indomethacin
Rôle des prostaglandines et du système bêta-adrénergique dans l'hyperkinésie centrale et périphérique de l'hypertension artérielle limite.