The use of vidarabine in the treatment of human polyomavirus associated acute haemorrhagic cystitis.
The human BK and JC polyomaviruses are known to be reactivated and excreted in the urine following bone marrow transplantation (BMT). A proportion of patients who excrete BK virus following BMT experience a haemorrhagic cystitis (HC), which may persist for many months. We report a case of human polyomavirus-associated HC, in whom treatment with vidarabine was associated with a dramatic response.
Chapman
C
C
Department of Haematology, Leicester Royal Infirmary, UK.
Flower
A J
AJ
Durrant
S T
ST
D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003556:Cystitis / Q000150:complications* / Q000188:drug therapy; D006470:Hemorrhage / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D011120:Polyomavirus; D014412:Tumor Virus Infections / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D014740:Vidarabine / Q000627:therapeutic use*
D014740:Vidarabine