Monoclonal antibodies to Kunjin and Kokobera viruses.
Five monoclonal antibodies (MoAb) were produced to the envelope (E) protein of Kunjin (KUN) virus. Three of these were specific for the KUN/West Nile complex, and two reacted with epitopes that were common to the flavivirus family. These MoAb defined at least four distinct epitopes on the E protein of KUN virus. Eight MoAb were also produced to unidentified proteins of Kokobera (KOK) virus. Seven were specific for KOK, while the remaining antibody cross-reacted with Stratford virus and an unregistered flavivirus CS946. The application of these MoAb to arboviral surveillance is discussed.
Hall
R A
RA
Queensland Institute of Medical Research, Herston, Australia.
Burgess
G W
GW
Kay
B H
BH
Clancy
P
P
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001103:Arboviruses / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005416:Flavivirus / Q000276:immunology*; D006825:Hybridomas; D051379:Mice; D008807:Mice, Inbred BALB C; D014759:Viral Envelope Proteins / Q000276:immunology; D014902:West Nile virus / Q000276:immunology
D000911:Antibodies, Monoclonal; D014759:Viral Envelope Proteins