Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects.
1. In this study an acute anti-hypertensive effect of three anti-oxidant agents (vitamin C, thiopronine and glutathione) in hypertensive subjects and in both hypertensive and non-hypertensive diabetic patients is reported. 2. The anti-oxidants had no effect on blood pressure in healthy normal subjects at a dose of 6 mmol, but thiopronine and glutathione produced a significant hypotensive effect at a dose of 12 mmol. 3. These data suggest that anti-oxidants might have a dilatatory effect and that an imbalance of the nitric oxide-free radical interaction might facilitate the development of hypertension in humans.
Ceriello
A
A
Cattedra di Diabetologia e Dietoterapia I Facoltà di Medicina, Università di Napoli, Italia.
Giugliano
D
D
Quatraro
A
A
Lefebvre
P J
PJ
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005978:Glutathione / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D008625:Tiopronin / Q000627:therapeutic use
D000975:Antioxidants; D008625:Tiopronin; D005978:Glutathione; D001205:Ascorbic Acid