[The evidence for the existence of an endogenous factor with digitalis activity in mammals: a physiological regulator of the sodium pump?].
In the last years a great deal of reports on the presence of endogenous digitalis-like activity in mammals have appeared in the literature. The active factor could be an endogenous ligand of the digitalis receptor and thus a physiological humoral regulator of sodium pump activity. Such an agent would necessary have a whole series of physiological and physiopathological implications. It has been proposed that the factor is a natriuretic hormone, that it participates in blood pressure regulation and in the genesis of arterial hypertension, that it plays a role in pregnancy and that it regulates cardiac contractility. These hypotheses are discussed in the present review.
Castañeda-Hernández
G
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Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del I.P.N., Calzada México-Xochimilco, D.F.
D000818:Animals; D001798:Blood Proteins / Q000737:chemistry / Q000502:physiology*; D002298:Cardenolides; D004077:Digoxin; D005260:Female; D006321:Heart / Q000502:physiology; D006801:Humans; D008322:Mammals / Q000502:physiology*; D009318:Natriuresis / Q000502:physiology; D045283:Natriuretic Agents / Q000502:physiology; D011247:Pregnancy; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000502:physiology*
D001798:Blood Proteins; D002298:Cardenolides; D045283:Natriuretic Agents; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase
Evidencias sobre la presencia de un factor endógeno con actividad digitálica en mamíferos: un regulador fisiológico de la bomba de sodio?