title: [The role of the hypophyseal-gonadal system in forming long-term nonhealing duodenal ulcers].
abstract: The authors provide the data on the hormonal spectrum (STH, gastrin, sex hormones) in patients with long unhealing duodenal ulcers. It is shown that changes in the concentrations and ratios of the concentrations of hypophyseal-gonadal hormones may serve as a defensive adaptation reaction of the body and may be due to activation of the adaptation systems that mediate the neurohumoral mechanisms of regulation. Such changes are more remarkable in patients with common peptic ulcer. Apparently, in patients with long unhealing ulcers, these mechanisms tend toward depletion, as a result of which the other mechanisms start prevailing (microcirculatory disorders, immunologic abnormalities, pathological microflora).
authors.forename: V N
authors.initials: VN
authors.lastname: Preobrazhenskiĭ
authors.forename: N P
authors.initials: NP
authors.lastname: Klimov
authors.forename: V L
authors.initials: VL
authors.lastname: Bazhanov
authors.forename: I L
authors.initials: IL
authors.lastname: Ostapenko
mesh_terms: D000328:Adult; D002908:Chronic Disease; D000242:Cyclic AMP / Q000097:blood; D004381:Duodenal Ulcer / Q000097:blood / Q000209:etiology*; D005260:Female; D005755:Gastrins / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D010053:Ovary / Q000503:physiopathology*; D010902:Pituitary Gland / Q000503:physiopathology*; D013737:Testis / Q000503:physiopathology*; D014945:Wound Healing
chemical_list: D005755:Gastrins; D012739:Gonadal Steroid Hormones; D013006:Growth Hormone; D000242:Cyclic AMP
vernacular_title: Rol' gipofizarno-gonadnoĭ sistemy v formirovanii dlitel'no nezazhivaiushchikh iazv dvenadtsatiperstnoĭ kishki.