Stimulation of adenosine A2 receptors induces catalepsy.
The central administration of the adenosine A2 agonist CGS 21680 induced catalepsy in the rat. This effect was counteracted by the previous systemic administration of the adenosine antagonist theophylline or the D2 agonist BHT-920. These results are in agreement with the view that adenosine A2 receptors regulate central dopamine D2 transmission and underline the potential antipsychotic activity of A2 agonists.
Ferré
S
S
Laboratori de Neuropsicofarmacologia, Fundació d'Investigació Sant Pau, Barcelona, Spain.
Rubio
A
A
Fuxe
K
K
D000241:Adenosine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced*; D008297:Male; D010627:Phenethylamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology; D011983:Receptors, Purinergic / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology
D001381:Azepines; D010627:Phenethylamines; D011954:Receptors, Dopamine; D011983:Receptors, Purinergic; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; C024763:talipexole; D013806:Theophylline; D000241:Adenosine