[Polyamine modulation of phosphorylation of channel-forming cytosolic protein in bovine brain].
Phosphorylation of the bovine brain TTX-sensitive cytosolic protein which is similar in several functional properties to the membrane potential-dependent sodium channel has been studied. The results obtained indicate that the cytosolic protein is a substrate for cAMP-dependent phosphorylation. Polyamines at a concentration of 5.0 mmol/l inhibit markedly phosphorylation of the cytosolic protein. Spermine is shown to be the most effective inhibitor. It is suggested that polyamines may modulate the cell sodium channel function.
Kastrikina
T F
TF
Malysheva
M K
MK
Surgova
T M
TM
D000818:Animals; D015317:Biogenic Polyamines / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D000242:Cyclic AMP / Q000502:physiology; D003600:Cytosol / Q000378:metabolism*; D008564:Membrane Potentials / Q000502:physiology; D010766:Phosphorylation; D011506:Proteins / Q000378:metabolism*; D015222:Sodium Channels / Q000502:physiology
D015317:Biogenic Polyamines; D011506:Proteins; D015222:Sodium Channels; D000242:Cyclic AMP
Modulirovanie poliaminami fosforilirovaniia kanalformernogo tsitozol'nogo belka mozga byka.