title: Dopamine increase in the nucleus accumbens of rats exposed to high pressure.
abstract: When human divers and experimental animals are exposed to high pressure, they develop the high pressure neurological syndrome (HPNS) characterized by electroencephalographic changes, sleep and behavioral disturbances. Free-moving rats chronically implanted in the nucleus accumbens with carbon electrodes essentially selective to dopamine (DA) were compressed to 80 bar. Compression was found to lead to a sustained increase in extracellular DA level (+88%), then during the stay and decompression phases, values progressively decreased. These results are discussed in the field of the involvement of the DA meso-limbic pathways in the occurrence of some of the behavioral disturbances of HPNS in rats including hyperlocomotor activity and hoarding behavior.
authors.affiliation: Laboratoire de biologie des hautes pressions, CNRS URA 1330, Faculte de médecine nord, Marseille, France.
authors.forename: J H
authors.initials: JH
authors.lastname: Abraini
authors.forename: J C
authors.initials: JC
authors.lastname: Rostain
mesh_terms: D000818:Animals; D001274:Atmospheric Pressure; D004298:Dopamine / Q000494:pharmacology*; D004563:Electrochemistry; D004566:Electrodes; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009434:Neural Pathways / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism / Q000502:physiology*; D011048:Polarography; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D004298:Dopamine