The in vivo inhibition of transport enzyme activities in different organs of rat by chlorpromazine is reversible.
Chlorpromazine, an antipsychotic drug is found to inhibit Na+K(+)-ATPase, Ca(2+)-ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vivo, when the drug is injected for certain periods of time. The inhibition seems to be due to the changes in fatty acid composition of lipid and microviscosity of the membranes. However, once the drug has been withdrawn, the enzyme activities are found to return to the normal level in three to five weeks, suggesting that the drug effect is reversible.
Adhikary
G
G
Department of Chemistry, Bose Institute, Calcutta, India.
Nandy
P
P
Chandra
S
S
Sikdar
R
R
Sen
P C
PC
D000110:Acetylcholinesterase / Q000187:drug effects*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors* / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D007425:Intracellular Membranes / Q000737:chemistry / Q000187:drug effects; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000032:analysis; D008565:Membrane Proteins / Q000037:antagonists & inhibitors*; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D009928:Organ Specificity; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors* / Q000187:drug effects*; D014783:Viscosity
D005227:Fatty Acids; D008563:Membrane Lipids; D008565:Membrane Proteins; D011683:Purine-Nucleoside Phosphorylase; D000110:Acetylcholinesterase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D002746:Chlorpromazine