title: [Progressive cytomegalovirus encephalitis in successful ganciclovir therapy of cytomegalovirus retinitis in an AIDS patient].
abstract: We describe a case of an HIV-infected intravenous drug-abuser who died of progressive cytomegalovirus encephalitis despite successful treatment of cytomegalovirus retinitis with ganciclovir. On autopsy, complete remission of retinitis and widespread cytomegalovirus-encephalitis could be demonstrated. Therapeutic failure therefore seems attributable to insufficient CNS-distribution of ganciclovir rather than to ganciclovir-resistant cytomegalovirus strains.
authors.affiliation: Medizinische Klinik der Universität Bonn.
authors.forename: S
authors.initials: S
authors.lastname: Ewig
authors.forename: E
authors.initials: E
authors.lastname: Bierhoff
authors.forename: W
authors.initials: W
authors.lastname: Luster
authors.forename: A
authors.initials: A
authors.lastname: Steudel
authors.forename: D
authors.initials: D
authors.lastname: Niese
mesh_terms: D015526:AIDS Dementia Complex / Q000188:drug therapy* / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D001921:Brain / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000473:pathology; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D012173:Retinitis / Q000188:drug therapy* / Q000473:pathology
chemical_list: D015774:Ganciclovir
vernacular_title: Progrediente Zytomegalie-Enzephalitis unter erfolgreicher Ganciclovir-Therapie einer Zytomegalie-Retinitis bei einem AIDS-Patienten.