Glioblastoma multiforme of the hippocampus in advanced Alzheimer's disease.
An 87-year-old woman suffered from Alzheimer's disease diagnosed 6 years prior to her death. Autopsy showed in addition to far-advanced Alzheimer's disease, a large, partially necrotic glioblastoma occupying her right hippocampus. Occurrence of a glial neoplasm in Alzheimer's disease could well be coincidental, since both entities are fairly common in elderly individuals; it is however, uncommon for gliomas to centre on the hippocampus itself. For these reasons it is possible (although cannot be proven from a single case), that florid reactive gliosis commonly associated with Alzheimer's disease, may have played a role in eventually initiating neoplastic proliferation of astrocytes in this patient.
Poole
E C
EC
Department of Pathology and Oncology, University of Kansas College of Health Sciences and Hospital, Kansas City.
Kepes
J J
JJ
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology*; D005260:Female; D005909:Glioblastoma / Q000150:complications / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans