Antiviral activities of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1) in vitro.
Chemically modified compounds of glycyrrhizin have been synthesized and evaluated for their inhibitory effect on the replication of human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1). Among them, the 11-deoxo compound having a heteroannular diene structure at the C and D rings proved as active against HIV-1 as glycyrrhizin in MT-4 and MOLT-4 cells. It completely inhibited HIV-1-induced cytopathogenicity in both cell lines at a concentration of 0.16 mM. The compound was also effective against HSV-1 with a 50% inhibitory concentration of 0.5 mM [corrected].
Hirabayashi
K
K
Research Laboratory, Minophagen Pharmaceutical Co., Kanagawa, Japan.
Iwata
S
S
Matsumoto
H
H
Mori
T
T
Shibata
S
S
Baba
M
M
Ito
M
M
Shigeta
S
S
Nakashima
H
H
Yamamoto
N
N
D000998:Antiviral Agents / Q000494:pharmacology*; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D015497:HIV-1 / Q000187:drug effects*; D018139:Simplexvirus / Q000187:drug effects*
D000998:Antiviral Agents; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid