title: Enhancement of radiosensitizing effect of the nitroimidazole derivative RK28 on the proliferation of MethA tumor cells in combined use with diethyldithiocarbamate.
abstract: The radiosensitizing effect of the nitroimidazole derivative RK28 and diethyldithiocarbamate (DDC), which is an inhibitor of superoxide dismutase activity, was examined in vitro by using Meth A tumor cells. The radiosensitizing effect of 0.5 mM RK28 was observed in both of 10 Gy and 15 Gy irradiated groups. The addition of 5 x 10(-7) M DDC also enhanced the radiation-induced proliferation inhibition. Marked enhancement of the antiproliferative effect was observed in combined use of 0.2 mM or 0.5 mM RK28 with 2 x 10(-7) M or 5 x 10(-7) M DDC. These results suggest that enhanced oxygen effect could be expected through combined use of the ionizing irradiation with both of these agents.
authors.affiliation: Division of Immunology, National Kyushu Cancer Center, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Mashiba
authors.forename: K
authors.initials: K
authors.lastname: Matsunaga
authors.forename: K
authors.initials: K
authors.lastname: Hata
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004050:Ditiocarb / Q000494:pharmacology*; D004357:Drug Synergism; D051379:Mice; D008807:Mice, Inbred BALB C; D008920:Misonidazole / Q000031:analogs & derivatives* / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects*
chemical_list: D003037:Cobalt Radioisotopes; D011838:Radiation-Sensitizing Agents; C047778:1-(4'-hydroxy-2'-butenoxy)methyl-2-nitroimidazole; D008920:Misonidazole; D004050:Ditiocarb; D013482:Superoxide Dismutase