Expression of the pp63 gene encoding the insulin receptor tyrosine kinase inhibitor in proliferating liver and in liver tumors.
After partial hepatectomy in rats, a approximately 4-fold decrease in pp63 mRNA level was detected at 24 h, but not at earlier time points. In mice, during liver cell proliferation induced by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbital, pp63 transcript levels had a decrease of 40-50%. However, pp63 mRNA was 5-6 fold higher in murine hepatocellular tumors than in normal adult mouse liver.
Colombo
B M
BM
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
Falquerho
L
L
Manenti
G
G
Dragani
T A
TA
Le Cam
A
A
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003433:Crosses, Genetic; D005260:Female; D015870:Gene Expression; D006023:Glycoproteins / Q000235:genetics*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008114:Liver Neoplasms, Experimental / Q000503:physiopathology*; D008115:Liver Regeneration; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D010634:Phenobarbital / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011725:Pyridines / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin; D060749:alpha-2-HS-Glycoprotein
C071388:Ahsg protein, rat; D006023:Glycoproteins; D011725:Pyridines; D012333:RNA, Messenger; D060749:alpha-2-HS-Glycoprotein; C028474:1,4-bis(2-(3,5-dichloropyridyloxy))benzene; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin; D010634:Phenobarbital