Comparative effects of pipecuronium and tubocurarine on plasma concentrations of histamine in humans.
We have examined the effects of a rapid bolus dose of pipecuronium 0.1 mg kg-1 or tubocurarine 0.5 mg kg-1 on plasma histamine concentration, heart rate and arterial pressure in 20 patients (n = 10 in each group). Anaesthesia was induced with thiopentone 6 mg kg-1 i.v. and maintained with 70% nitrous oxide and halothane in oxygen. Neuromuscular blocking drugs were administered 4 min after administration of thiopentone. Venous blood samples were obtained before induction, 1 min after thiopentone and 1, 3 and 5 min after the administration of the neuromuscular blocking drugs. Tubocurarine caused 240% and 210% increases in plasma concentration of histamine at 1 and 3 min, respectively. These changes were significant (P less than 0.05) at 1 min and associated with a decrease in mean arterial pressure and an increase in heart rate. None of the 10 patients receiving pipecuronium had a significant change in plasma concentration of histamine or in haemodynamic variables.
Naguib
M
M
Department of Critical Care Medicine, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain.
Abdulatif
M
M
Absood
A
A
D000328:Adult; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000494:pharmacology; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000097:blood*; D006801:Humans; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D017300:Pipecuronium; D010879:Piperazines / Q000494:pharmacology*; D013997:Time Factors; D014403:Tubocurarine / Q000494:pharmacology*
D009466:Neuromuscular Blocking Agents; D010879:Piperazines; D017300:Pipecuronium; D015113:Androstane-3,17-diol; D006632:Histamine; D014403:Tubocurarine