New principle in QSAR: membrane requirements.
In this review I discuss our recent work on the possible role of the lipid phase of the target cell membrane in mediating receptor subtype selectivity of peptides.
Schwyzer
R
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Department of Molecular Biology and Biophysics, Swiss Federal Institute of Technology, Zürich.
D000595:Amino Acid Sequence; D002384:Catalysis; D008563:Membrane Lipids / Q000502:physiology*; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D013329:Structure-Activity Relationship
D008563:Membrane Lipids; D010455:Peptides; D011956:Receptors, Cell Surface