Familial predisposition to Wilms tumor does not segregate with the WT1 gene.
Wilms tumor (WT) is one of the more common childhood cancers. A small fraction of WT occurs in association with aniridia, genitourinary abnormalities and mental retardation, the WAGR syndrome, and these cases often are accompanied by a constitutional deletion of all or part of band 11p13. Recently a WT susceptibility gene (WT1), localized to 11p13, has been isolated and shown to be inactivated in some sporadic WTs. In the present study, a highly informative CA repeat polymorphism within the gene was studied in a family with six affected members in three generations. Predisposition to WT in this large family did not segregate with this polymorphism. Furthermore, linkage analysis indicated exclusion of WT predisposition from 11p15. These results provide definitive evidence that familial predisposition to WT can be mediated by a gene other than WT1.
Schwartz
C E
CE
Greenwood Genetic Center, South Carolina 29646.
Haber
D A
DA
Stanton
V P
VP
Strong
L C
LC
Skolnick
M H
MH
Housman
D E
DE
D000483:Alleles; D002675:Child, Preschool; D002871:Chromosome Banding; D002880:Chromosomes, Human, Pair 11; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D009396:Wilms Tumor / Q000235:genetics*