title: Long-lasting enhancement of the membrane-associated protein kinase C activity in the hippocampal kindled rat.
abstract: We demonstrated that only membrane-associated protein kinase C (PKC) activity increased in the bilateral hippocampus (HIPP) up to 4 weeks and in the amygdala/pyriform cortex (AM/PC) at 4 weeks after the last kindled seizure. The enhancement of the membrane-associated PKC activity exceeds the increase in the protein concentration, which was observed in part. The overwhelming increase in the PKC activity should be of significance in the long-term maintenance of the kindling phenomenon.
authors.affiliation: Department of Neuropsychiatry, Okayama University Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Daigen
authors.forename: K
authors.initials: K
authors.lastname: Akiyama
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: I
authors.initials: I
authors.lastname: Kohira
authors.forename: I
authors.initials: I
authors.lastname: Sora
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: S
authors.initials: S
authors.lastname: Otsuki
mesh_terms: D000818:Animals; D001931:Brain Mapping; D003600:Cytosol / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004827:Epilepsy / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology*; D007696:Kindling, Neurologic / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology*; D051381:Rats; D013570:Synaptic Membranes / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D011493:Protein Kinase C