[Evaluation of the fibrogenic effect of coke dust on the lungs and internal organs of experimental animals].
Based on the data collected by the Provincial Regional Administration Unit for Control of Epidemics and Hygiene in Katowice, dust concentration at the MAKOSZOWY Coking Plant in Zabrze at 18 work-places exceeded the TLV's. The purpose of this study was to determine changes within the respiratory systems of experimental animals exposed to intratracheal administration of MAKOSZOWY Coking Plant dust, sampled at the charging larry 3-4 operating stand and at the battery roof. After pulverization the dusts contained 98.1% and 99.6% respirable particles, and 6.5% and 6.0% of SiO2, respectively, determined with the Polezhajev method. They also contained aluminum and iron compounds. Hydroxyproline content in the lungs of the animals following the intratracheal administration of 50 mg of the dusts investigated 3-6 months after the experiment was determined. Determination of Hypro contend within the animals' lungs was pursued with the Stegemann method as modified by Hurych and Chvapil. The biochemical investigation results obtained were statistically analyzed with the t-Student's Test. Single intratracheal administration of dust from the battery roof work stand of the MAKOSZOWY Coking Plant caused within 6 months a statistically significant increase in the lung Hydroxyproline level in experimental animals (t = 13.10). An almost triole Hypro increase with respect to the control group was observed. No analogy between lung Hypro level increase (12.833 mg) and histological change was noted. Such a significant lung Hydroxyproline level increase could have been due to the SiO2 content of dust (6%), as well as to the presence of iron compounds in it (4.98%).(ABSTRACT TRUNCATED AT 250 WORDS)
Zyłka-Włoszczyk
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M
Zakładu Doświadczalnej Patologii Pracy Instytutu Medycyny Pracy w Sosnowcu.
Ociepiński
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M
Szaflarska-Stojko
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E
D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D002617:Chemical Industry; D003077:Coke; D004195:Disease Models, Animal; D004391:Dust / Q000009:adverse effects; D005290:Ferric Compounds / Q000009:adverse effects*; D006909:Hydroxyproline / Q000378:metabolism*; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012822:Silicon Dioxide / Q000009:adverse effects*; D012829:Silicosis / Q000209:etiology*
D000393:Air Pollutants; D003077:Coke; D004391:Dust; D005290:Ferric Compounds; C000499:ferric oxide; D012822:Silicon Dioxide; D006909:Hydroxyproline
Ocena zwłókniajçego działania pyłów koksowniczych w płucach i narzadach wewnetrznych zwierzat doświadczalnych.