[Unscheduled DNA synthesis of peripheral blood lymphocytes in pedigrees of hepatocellular carcinoma patients].
Levels of unscheduled DNA synthesis (UDS) of peripheral blood lymphocytes were measured by liquid scintigraphy in 23 patients with hepatocellular carcinoma (HCC), 42 first-degree relatives of HCC, 17 carriers of HBsAg, and 47 controls in order to evaluate the effects of HN2.HCl on the damage and repair of cell DNA, the effects of genetic susceptibility on the development of HCC, and the relationship between genetic susceptibility and hepatitis B virus (HBV) infection. The results were: 1. UDSs were significantly increased in the peripheral blood lymphocytes from patients with HCC and their first-degree relatives, and higher than those of the controls (P less than 0.005). 2. UDS in HBsAg carriers was significantly higher than that of the controls (P less than 0.05), 3. The difference of UDS was also remarkable between the HBsAg-negative patients with HCC and their first-degree relatives and the controls (P less than 0.01). These results suggest that the development of HCC might be due to the combined effects of environmental factors and genetic susceptibility. As an environmental factor, HBV infection might play role in hepato-carcinogenesis in individuals with or without a genetic background.
Wang
J B
JB
Qidong Liver Cancer Institute, Jiangsu.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D002353:Carrier State; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005260:Female; D006509:Hepatitis B / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D004273:DNA, Neoplasm