Overexpression of extracellular matrix receptors (VLA-3, 5 and 6) on psoriatic keratinocytes.
The potential role of adhesion molecules in the pathophysiology of psoriasis was investigated and the pattern of expression of the cell-surface receptors ICAM-1, LFA-3, and VLA-1, 2, 3, 4, 5 and 6 was determined in biopsies of skin from patients with psoriasis (n = 12) and from normal skin (n = 12). There were no differences in the intensity or localization of the adhesion molecules VLA-1, 2 and 4 and LFA-3. In contrast, VLA-3 and VLA-6, which are restricted to the basal keratinocytes in normal skin, were overexpressed in the spinous cells in psoriatic skin. ICAM-1 and VLA-5, which are not expressed by keratinocytes in normal skin, were focally induced, especially in cells above elongated rete ridges and where there was an infiltrate with intraepidermal granulocytes and lymphocytes.
Kellner
I
I
Department of Dermatology, University of Kiel, Germany.
Konter
U
U
Sterry
W
W
D000911:Antibodies, Monoclonal; D002908:Chronic Disease; D004817:Epidermis / Q000737:chemistry; D016326:Extracellular Matrix Proteins / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D015603:Keratinocytes / Q000737:chemistry*; D011565:Psoriasis / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000032:analysis*
D000911:Antibodies, Monoclonal; D016326:Extracellular Matrix Proteins; D011956:Receptors, Cell Surface; C052131:extracellular matrix receptor