In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression.
Twelve severely depressed patients and 13 healthy controls were studied under baseline, metyrapone and metyrapone plus dexamethasone pretreated conditions. Lymphocyte proliferation data were obtained by concanavalin A, phytohaemagglutinin and pokeweed mitogen (PWM) stimulation. There was a decrease in PWM-induced B-cell proliferation and an increase in inhibition of spontaneous leucocyte proliferation by dexamethasone added in vitro following metyrapone administration in vivo, in healthy controls, which was not present in the depressed patients. These data support the concept of a decreased functional plasticity of the glucocorticoid receptor in depression also at the cellular level.
Rupprecht
R
R
Department of Psychiatry, University of Würzburg, Federal Republic of Germany.
Wodarz
N
N
Kornhuber
J
J
Wild
K
K
Schmitz
B
B
Braner
H U
HU
Müller
O A
OA
Riederer
P
P
Beckmann
H
H
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000276:immunology*; D003866:Depressive Disorder / Q000276:immunology*; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D008875:Middle Aged; D011965:Receptors, Glucocorticoid / Q000187:drug effects* / Q000502:physiology
D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone; D008797:Metyrapone