title: Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg).
abstract: Structural definition of the receptors for neurotropic and angiogenic modulators such as fibroblast growth factors and related polypeptides will yield insight into the mechanisms that control early development, embryogenesis, organogenesis, wound repair and neovessel formation. We isolated 3 murine cDNAs encoding different binding domains of these receptors (flg). Comparison of these ectoplasmic portions showed that two of the forms corresponded to previously described murine molecules whereas the third one had a different ectoplasmic portion generated by specific changes in two regions. Interestingly, expression of this third form seems to be restricted in its tissue distribution. Such modifications could influence the ligand specificity of the different receptors and/or their binding affinity.
authors.affiliation: Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.
authors.forename: N J
authors.initials: NJ
authors.lastname: Fasel
authors.forename: M
authors.initials: M
authors.lastname: Bernard
authors.forename: N
authors.initials: N
authors.lastname: Déglon
authors.forename: M
authors.initials: M
authors.lastname: Rousseaux
authors.forename: R J
authors.initials: RJ
authors.lastname: Eisenberg
authors.forename: C
authors.initials: C
authors.lastname: Bron
authors.forename: G H
authors.initials: GH
authors.lastname: Cohen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016375:Antisense Elements (Genetics); D001483:Base Sequence; D002460:Cell Line; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D005346:Fibroblast Growth Factors / Q000378:metabolism; D000091344:Filaggrin Proteins; D006801:Humans; D007739:L Cells / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D011956:Receptors, Cell Surface / Q000235:genetics*; D017468:Receptors, Fibroblast Growth Factor; D012259:Ribonuclease, Pancreatic; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D016375:Antisense Elements (Genetics); C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D015345:Oligonucleotide Probes; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; D004247:DNA; D012259:Ribonuclease, Pancreatic