Influence of chronic lithium treatment on urinary amount of furosemide in rats.
The present study was undertaken to examine whether the urinary amount of furosemide is influenced by chronic lithium treatment. LiCl at 2 mEq/kg/day in 1 ml vehicle (5% glucose solution) or 1 ml of vehicle alone was injected intraperitoneally for 8 days into Wistar rats. On day 8, 30 mg/kg of furosemide in 3% body weight of 1% NaCl was given orally, and urine was collected for 6 hr after dosage. The urinary amount of furosemide in the Li-treated rats was significantly lower than that in the control animals [Li group (n = 12): 514 +/- 75 (mean +/- S.E.) vs. control group (n = 12): 916 +/- 85 micrograms/kg/6 hr, P less than 0.01]. This finding indicates that pharmacokinetic alterations of furosemide might occur during chronic treatment with lithium.
Fujimura
A
A
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Ohashi
K
K
Ebihara
A
A
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology*; D004326:Drinking; D005665:Furosemide / Q000008:administration & dosage / Q000652:urine*; D008094:Lithium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D014556:Urine
D002712:Chlorides; D005665:Furosemide; D008094:Lithium; D012083:Renin; D018021:Lithium Chloride