Palindromic morphea: multiple recurrence of morphea lesions in a case of systemic sclerosis.
We report an unusual scleroderma case. A 45-year-old woman had recurrent morphea lesions over 10 times in 6 years. She had had preceding inactive systemic scleroderma. New morphea lesions developed cyclically on various portions of her body and improved within 2 years. Interestingly, new lesions have developed on once involved skin as well as uninvolved skin. No exacerbation of systemic scleroderma was induced by outbreaks of new morphea lesions. We could not find a similar case in the literature and named it "Palindromic morphea" because of its unique clinical course. D-penicillamine treatment had a limited effect. Minimal oral prednisolone (5 mg/day) completely suppressed the multiple recurrence of the morphea lesions and enhanced improvement of the sclerosis.
Mizutani
H
H
Department of Dermatology, Mie University School of Medicine, Japan.
Tanaka
H
H
Okada
H
H
Mizutani
T
T
Shimizu
M
M
D005260:Female; D006801:Humans; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence; D012594:Scleroderma, Localized / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000473:pathology; D013997:Time Factors
D011239:Prednisolone; D010396:Penicillamine