Intragastric positioning of two concurrently ingested pharmaceutical matrix dosage forms.
A triple nuclide scintigraphic technique is presented for the precise and lasting intragastric monitoring in man of two concurrently ingested hydrophilic matrix pharmaceutical forms. After in vitro testing of various labels, ion exchange resin-coupled 201T1- and 111In-oxinate were selected for their release characteristics. 99mTc-pertechnetate oral solution was used to selectively delineate the stomach. This technique was validated on healthy volunteers. It allowed measurement of the effects on gastric residence time of galenic parameters (size, density of matrices), as well as of physiological parameters such as subject posture.
Van Gansbeke
B
B
Service des Radio-Isotopes, Hôpital Erasme, Cliniques Universitaires de Bruxelles, Belgium.
Timmermans
J
J
Schoutens
A
A
Moës
A J
AJ
D000328:Adult; D004337:Drug Carriers; D006801:Humans; D007205:Indium Radioisotopes / Q000008:administration & dosage; D008297:Male; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m / Q000008:administration & dosage; D013270:Stomach / Q000000981:diagnostic imaging*; D013691:Tellurium / Q000008:administration & dosage
D004337:Drug Carriers; D007205:Indium Radioisotopes; D013670:Sodium Pertechnetate Tc 99m; D013691:Tellurium