[The mechanism of the effects of 654-2 and vitamin E on hyperoxic lung injury].
The changes of free radicals and the effect of anisodamine and vitamin E on hyperoxic lung injury were studied. Ninety adult Wistar rats were exposed to greater than 95% O2. Nine a normal rats served as controls. The animals in group A were only exposed to hyperoxia, while in group B and C, they were treated intramuscularly with anisodamine (15 mg/kg, bid) and vitamin E (75 mg/kg, bid) respectively. The rats in each group were killed after 12, 24 or 48 hours oxygen exposure. The blood and lung were examined for SOD, GSH-PX and MDA. In Group A, the quantity of peroxide free radical increased 20%. The activity of SOD and GSH-PX decreased and MDA increase were in lower degree. Changes of SOD, GSH-PX, MDA, PaO2 and lung damage were also in lower degree. The results indicated that the increase of oxygen free radicals may be the pathophysiological factor in hyperoxic lung injury.
Zhang
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Y
Beijing Army General Hospital.
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D005979:Glutathione Peroxidase / Q000378:metabolism; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D008171:Lung Diseases / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010100:Oxygen / Q000633:toxicity; D011654:Pulmonary Edema / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000627:therapeutic use*
D012991:Solanaceous Alkaloids; C003922:anisodamine; D014810:Vitamin E; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D010100:Oxygen