Inositol phospholipids-specific phospholipase C: interaction of the gamma 1 isoform with tyrosine kinase.
The generation of second messengers from inositol phospholipids is catalysed by enzymes from the phospholipase C family. Activation of phospholipase C-gamma 1 through tyrosine phosphorylation provides a link between mitogenic and inositol phospholipid signaling.
Rhee
S G
SG
Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
D000595:Amino Acid Sequence; D000818:Animals; D004789:Enzyme Activation; D010716:Phosphatidylinositols / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D012689:Sequence Homology, Nucleic Acid; D010738:Type C Phospholipases / Q000235:genetics / Q000378:metabolism*
D010716:Phosphatidylinositols; D011505:Protein-Tyrosine Kinases; D010738:Type C Phospholipases