[IgA changes in chronic alcoholic hepatopathy].
Chronic alcoholic hepatitis (CAH) has been included, in the last 10 years, among the disease accompanied by particular changes of IgA (primary glomerulonephritis with mesangial deposits of IgA, Berger; Henoch-Schonlein's purpura with IgA deposits in dermatic capillaries and herpetiform dermatitis, with deposits of IgA in dermatic papillae). The characteristics of IgA involvement in CAH are: The whole IgA system is changed, at its 3 levels: circulatory, tissular, formative. at the circulatory level, the IgA2 monomeric fraction increases characteristically; in hepatic parenchyma, perisinusoidal linear deposits of IgA are formed; they have a great significance for the alcoholic etiology, the length of time and seriousness of alcoholism.
Voinea
F
F
Clinica I Medicală, Craiova.
Mixich
F
F
Ciurea
P
P
Găman
G
G
Badea
M
M
D002908:Chronic Disease; D004064:Digestive System / Q000503:physiopathology; D006801:Humans; D007109:Immunity; D007070:Immunoglobulin A / Q000097:blood*; D008099:Liver / Q000503:physiopathology; D008108:Liver Diseases, Alcoholic / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology
D007070:Immunoglobulin A
Modificări ale IgA în hepatopatia cronică alcoolică.