The mechanism of action of the anti-herpes virus compound 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline.
The compound 2,3-dimethyl-6(2-dimethylaminoethyl)6H-indolo-(2,3-b)quinoxaline (B-220) has been shown to exhibit potent antiviral activity against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV) and cytomegalovirus (CMV). The mechanism of antiviral action of B-220 against HSV-1 has been studied; from the results it appears that B-220 binds by intercalation into the DNA helix and then disturbs steps that are vital for viral uncoating.
Harmenberg
J
J
Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
Akesson-Johansson
A
A
Gräslund
A
A
Malmfors
T
T
Bergman
J
J
Wahren
B
B
Akerfeldt
S
S
Lundblad
L
L
Cox
S
S
D000327:Adsorption; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D002213:Capsid / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line; D002478:Cells, Cultured; D004279:DNA, Viral / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D011810:Quinoxalines / Q000378:metabolism / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D013053:Spectrophotometry; D013696:Temperature
D000998:Antiviral Agents; D004279:DNA, Viral; D007211:Indoles; D011810:Quinoxalines; C060183:B 220