Melanocyte-stimulating hormone (alpha-MSH) inhibits the growth of human malignant melanoma cells with the induction of phosphatidyl inositol and myo-inositol phosphate levels.
It has been shown that alpha-MSH inhibits the growth of amelanotic cells of human malignant melanoma (BRO) without their melanization or the expression of tyrosinase activity. alpha-MSH changed the activity of cytosol and microsomal forms of phosphatidyl inositol kinase and phosphatidyl inositol-4-phosphate kinase determining the concentration of phosphatidyl inositol-4-phosphate and phosphatidyl inositol-4,5-bisphosphate. It also induced an "outburst" in the levels of myo-inositol phosphates (mono-, bis- and 1,4,5-trisphosphates). Changes in the levels of myo-inositol phosphates occurred within seconds, and are suggested to play a certain part in the hormonal regulation of melanoma cell growth.
Sukhanov
V A
VA
All-Union Research Center of Molecular Diagnostics and Therapy, USSR Ministry of Health, Moscow.
Voronkova
I M
IM
Shvets
S V
SV
Dyakov
V L
VL
Morozova
L F
LF
D019870:1-Phosphatidylinositol 4-Kinase; D002455:Cell Division / Q000502:physiology*; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism*; D007700:Kinetics; D008543:Melanins / Q000378:metabolism; D008545:Melanoma; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism*; D010770:Phosphotransferases / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor); D014407:Tumor Cells, Cultured; D000521:alpha-MSH / Q000502:physiology*
D007295:Inositol Phosphates; D008543:Melanins; D010716:Phosphatidylinositols; D000521:alpha-MSH; D014442:Monophenol Monooxygenase; D010770:Phosphotransferases; D017853:Phosphotransferases (Alcohol Group Acceptor); D019870:1-Phosphatidylinositol 4-Kinase; C020077:1-phosphatidylinositol-4-phosphate 5-kinase