title: In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.
abstract: Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.
authors.affiliation: Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901.
authors.forename: A M
authors.initials: AM
authors.lastname: Dhople
authors.forename: L C
authors.initials: LC
authors.lastname: Lamoureux
authors.forename: G D
authors.initials: GD
authors.lastname: Gardner
mesh_terms: D000818:Animals; D002991:Clofazimine / Q000494:pharmacology*; D003470:Culture Media; D003622:Dapsone / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D007917:Leprostatic Agents / Q000494:pharmacology*; D007918:Leprosy / Q000188:drug therapy / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000254:growth & development; D017828:Rifabutin; D012293:Rifampin / Q000494:pharmacology*; D012294:Rifamycins / Q000494:pharmacology
chemical_list: D003470:Culture Media; D007917:Leprostatic Agents; D012294:Rifamycins; D017828:Rifabutin; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin