[Influence of verapamil and diltiazem on the muscle-relaxing effect of atracurium in vivo].
The interaction between atracurium and the two calcium antagonists verapamil and diltiazem were studied in rabbits. It was observed that intravenous verapamil (0.2 mg/kg) reduced by 25% and 30% respectively, the dose of atracurium required to produce a 50% or 95% of neuromuscular blockade. In contrast, intravenous diltiazem (1 mg/kg) failed to produce significant changes.
Gómez Iglesias
E
E
Departamento de Farmacología, Hospital de Galdakao.
García Pascual
E
E
Aguirre Gómez
C
C
Rodríguez-Sasiaín
J M
JM
Calvo Duo
R
R
D000818:Animals; D001279:Atracurium / Q000008:administration & dosage / Q000494:pharmacology*; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D009126:Muscle Relaxation / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
D011978:Receptors, Nicotinic; D001279:Atracurium; D014700:Verapamil; D004110:Diltiazem
Influencia de verapamilo y diltiazem sobre el efecto relajante muscular del atracurio in vivo.