title: Heredo-ataxia in a large Dutch pedigree. M.R.I. findings.
abstract: One segment of a large Dutch pedigree with heredo-ataxia is presented. The clinical and genetic features of the disease, together with the M.R.I. findings, indicate the diagnosis of autosomal dominant late onset olivo-ponto-cerebellar atrophy. The clinical picture remained invariant through successive generations. Emphasis is put on the diagnostic usefulness of M.R.I. technique in the absence of neuropathological data.
authors.affiliation: Department of Neurology, Oudenrijn Hospital, Utrecht, The Netherlands.
authors.forename: W E
authors.initials: WE
authors.lastname: Vliegenthart
authors.forename: G J
authors.initials: GJ
authors.lastname: Vielvoye
authors.forename: L P
authors.initials: LP
authors.lastname: Kuyt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D009849:Olivopontocerebellar Atrophies / Q000175:diagnosis* / Q000235:genetics*; D010375:Pedigree; D010865:Pilot Projects; D013132:Spinocerebellar Degenerations / Q000175:diagnosis* / Q000235:genetics*