[The prevention of a postinfarct fall in pressure and hyperactivation of the aortic endothelium in the rat by using the antioxidant ionol].
The stress concomitant with experimental myocardial infarction resulted in endothelial hyperactivation of the isolated rat aorta. The hyperactivation was manifested in potentiated inhibition of norepinephrine-induced contractions of vascular smooth muscle, increased endothelium-dependent relaxation and respective drop of systemic blood pressure. Preliminary treatment of animals with synthetic antioxidant ionol prevented the stress-induced endothelial hyperactivation and beneficially affected the postinfarction time course of blood pressure. The data suggest that the endothelial hyperactivation observed in acute myocardial infarction is induced by stress-induced activation of free-radical oxidation which results in a hyperproduction of endothelium-derived relaxing factor (nitric oxide).
Meerson
F Z
FZ
Lapshin
A V
AV
Manukhina
E B
EB
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D002084:Butylated Hydroxytoluene
Preduprezhdenie postinfarktnogo padeniia davleniia i giperaktivatsii éndoteliia aorty krysy s pomoshch'iu antioksidanta ionola.