[Anti-arrhythmia effect of digoxin antibodies in experimental myocardial infarct (arrhythmogenic action of endogenous digoxin-like factor)].
Suggesting endogenous digoxin-like factor (EDLF) to display arrhythmogenic activities in myocardial ischemia (MI), we studied the effect of anti-digoxin antiserum (ADS) on the ventricular fibrillation threshold (VFT) after the coronary ligation in cats and ventricular arrhythmias caused by MI in rats and chloroform-induced hypoxia in mice. Intravenous administration of ADS (5 mg/kg) enhanced VFT in cats with MI from 11.3 +/- 1.6 to 53.3 +/- 8.1 V (M +/- m; p less than 0.01) and significantly reduced ventricular arrhythmias in rats and mice. Our experiments on the isolated electro-stimulated rat atria demonstrated that EDLF is likely not to be an adrenergic cotransmitter in the heart. Possible mechanisms of the arrhythmogenic action of EDLF are discussed.
Bagrov
A Ia
AIa
Research Institute of Endocrinology, Prague, Chechoslovakia.
Veveris
M M
MM
Ganelina
I E
IE
Nikiforova
K A
KA
Osipov
V L
VL
Rukoiatkina
N I
NI
Shtol'ba
P
P
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000276:immunology; D001798:Blood Proteins / Q000502:physiology*; D002298:Cardenolides; D002415:Cats; D004077:Digoxin / Q000276:immunology*; D006352:Heart Ventricles; D007106:Immune Sera / Q000276:immunology; D008297:Male; D051379:Mice; D009203:Myocardial Infarction / Q000150:complications*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D014693:Ventricular Fibrillation / Q000209:etiology
D000906:Antibodies; D001798:Blood Proteins; D002298:Cardenolides; D007106:Immune Sera; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase
Protivoaritmicheskiĭ éffekt antitel k digoksinu pri éksperimental'nom infarkte miokarda (ob aritmogennom deĭstvii éndogennogo digoksinopodobnogo faktora).