The capsid protein-encoding sequence of foot-and-mouth disease virus O2Brescia.
Nucleotide sequences encoding the four capsid proteins of foot-and-mouth disease virus subtype O2Brescia/1947 have been determined. These and the deduced amino acid sequences were compared with those of a subtype O1 virus strain. The nucleotide sequences differed at 259 positions, causing only 35 amino acid changes. VP4 and VP2 differed by 2.4 and 1.8%, whereas VP1, known as major viral antigen, and VP3 differed by 8% and 5.5%, respectively. The differences occur mainly in protein domains not involved in the formation of alpha-helices and beta-sheets, suggesting that the surfaces of both viruses are more variable than their scaffolds. The O2Brescia sequence has been submitted to the GenBank data base and has the accession number M 55287.
Krebs
O
O
Federal Research Centre for Virus Diseases of Animals, Tübingen, Federal Republic of Germany.
Berger
H G
HG
Marquardt
O
O
D000595:Amino Acid Sequence; D005537:Aphthovirus / Q000235:genetics*; D001483:Base Sequence; D002213:Capsid / Q000235:genetics*; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D012703:Serotyping; D013045:Species Specificity