Familial juvenile polyposis coli and colorectal cancer.
A 40-year-old mother and her 7-year-old son underwent colectomy for polyposis coli. Both colectomy specimens contained predominantly juvenile polyps. The mother's specimen also had numerous tubular adenomas and one 5-cm severely dysplastic villous adenoma without invasive carcinoma. Foci of adenomatous change in juvenile polyps were present in the son's specimen. The histologic features of both cases suggest a sequence of change from juvenile polyps to adenomatous polyps to cancer.
O'Riordain
D S
DS
Department of Surgery, University College, Dublin, Ireland.
O'Dwyer
P J
PJ
Cullen
A F
AF
McDermott
E W
EW
Murphy
J J
JJ
D011125:Adenomatous Polyposis Coli / Q000473:pathology*; D000328:Adult; D002648:Child; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D011230:Precancerous Conditions