Plasma cyclic AMP increases in hamsters following exposure to a graded footshock stressor.
To assess the utility of plasma cyclic AMP (cAMP) as a sensitive physiological index of an animal's arousal level, we exposed male hamsters to various intensities (0.0-2.0 mA) of a footshock stressor. The plasma cAMP response was directly related to stimulus intensity. Ratings of behavioral arousal were positively correlated with plasma cAMP values. We conclude that plasma cAMP may be a useful index of arousal.
Huhman
K L
KL
Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, D.C.
Hebert
M A
MA
Meyerhoff
J L
JL
Bunnell
B N
BN
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D006224:Cricetinae; D000242:Cyclic AMP / Q000097:blood*; D004558:Electric Stimulation; D008297:Male; D008647:Mesocricetus / Q000097:blood*; D011863:Radioimmunoassay; D013312:Stress, Physiological
D000242:Cyclic AMP