title: (-)-N,N'-but-2-ene-1,4-diylbimorphinans.
abstract: N,N'-But-2-ene-1,4-diylbimorphinans 1-3 have been synthesized and pharmacologically evaluated. Bimorphinans 1 and 3 show opioid antagonist activity and preference for mu and kappa opioid receptors in mouse vas deferens and guinea pig ileum preparations.
authors.affiliation: Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Schmidhammer
authors.forename: C F
authors.initials: CF
authors.lastname: Smith
authors.forename: E
authors.initials: E
authors.lastname: Dalkner
authors.forename: D
authors.initials: D
authors.lastname: Erlach
authors.forename: M
authors.initials: M
authors.lastname: Heuberger
authors.forename: J M
authors.initials: JM
authors.lastname: Rollinger
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009019:Morphinans / Q000138:chemical synthesis* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma; D014649:Vas Deferens / Q000187:drug effects
chemical_list: D009019:Morphinans; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma