[Beta 2-microglobulinuria in cytomegalovirus infections following kidney transplantation].
In a prospective study the occurrence of cytomegalovirus (CMV) infection was diagnosed by demonstrating CMV-immediate early antigen (IEA) in the blood in 13 out of 68 (19%) patients who had undergone renal transplantation (27 women, 41 men, mean age 46.3 [21-64] years). Twenty-four hour urine samples were collected at the same time for quantitative determination of selected marker proteins by immunoluminometric assays (IgG and transferrin as glomerular markers, alpha 1-microglobulin and beta 2-microglobulin as tubular markers). In all 13 confirmed cases of CMV infection there was an isolated rise in urinary beta 2-microglobulin excretion amounting to more than three times the normal. In 11 of the 13 cases the beta 2-microglobulinuria was noted before the CMV-IEA test became positive. This suggests that quantitative assay of beta 2-microglobulin in the urine may be of value in the early diagnosis of CMV infection--a matter of some prognostic importance--and may hence offer additional support for therapeutic decisions.
Steinhoff
J
J
Klinik für Innere Medizin, Universität Lübeck.
Feddersen
A
A
Wood
W G
WG
Bein
G
G
Preuss
R
R
Fricke
L
L
Sack
K
K
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000954:Antigens, Surface / Q000097:blood; D000956:Antigens, Viral / Q000097:blood; D015415:Biomarkers / Q000652:urine; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000276:immunology / Q000652:urine*; D005260:Female; D006801:Humans; D017874:Immediate-Early Proteins; D007075:Immunoglobulin M / Q000032:analysis; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000276:immunology / Q000652:urine*; D011446:Prospective Studies; D011507:Proteinuria / Q000276:immunology / Q000652:urine; D001613:beta 2-Microglobulin / Q000652:urine*
D000914:Antibodies, Viral; D000954:Antigens, Surface; D000956:Antigens, Viral; D015415:Biomarkers; D017874:Immediate-Early Proteins; D007075:Immunoglobulin M; D001613:beta 2-Microglobulin; C044582:immediate-early proteins, cytomegalovirus
Beta 2-Mikroglobulinurie bei Cytomegalievirus-Infektionen nach Nierentransplantation.