Schistosoma mansoni: angiotensin converting enzyme activity in mice under the influence of praziquantel and/or captopril.
Murine schistosomiasis is usually associated with hepatic granulomatous lesions together with high serum and granuloma angiotensin converting enzyme (ACE) activity. Praziquantel (PRZ) which is known to reduce granuloma size was studied to show whether this effect is related to changes in ACE activity. Furthermore, captopril was studied to show whether by inhibiting ACE activity, the drug could also affect granuloma size. PRZ, captopril, and their combination led to significant reduction in liver granuloma. However, in normal mice, captopril was shown to increase rather than decrease serum ACE. The decrease in ACE activity by PRZ was correlated with its curative effect in infected mice. However, in experimentally induced pulmonary granulomata, the drug reduced granuloma size without affecting ACE activity of either serum or granuloma. It may be concluded that reduction in ACE activity may be beneficial as far as diminution of granuloma size is concerned and irrespective of whether there is an active infection or not. The possible use of Captopril as an antihypertensive in bilharzial infections associated with hypertension would probably not adversely affect the granulomatous lesions.
Khayyal
M T
MT
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Egypt.
Saleh
S
S
Metwally
A A
AA
Botros
S S
SS
Mahmoud
M R
MR
D000818:Animals; D002216:Captopril / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000201:enzymology / Q000473:pathology; D007422:Intestines / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D008109:Liver Diseases, Parasitic / Q000201:enzymology / Q000473:pathology; D051379:Mice; D010270:Parasite Egg Count; D007703:Peptidyl-Dipeptidase A / Q000097:blood* / Q000378:metabolism; D011223:Praziquantel / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000187:drug effects; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000201:enzymology* / Q000469:parasitology / Q000473:pathology
D011223:Praziquantel; D002216:Captopril; D007703:Peptidyl-Dipeptidase A