Mobilization of cadmium by liposome-encapsulated meso-2,3-dimercaptosuccinic acid in pre-exposed mice.
meso-2,3-Dimercaptosuccinic acid (DMSA) treatment in free of liposome-encapsulated form was given to mice pre-exposed to cadmium as CdCl2 (2 intraperitoneal injections; 0.5 mg Cd/kg along with 5 microCi 109CdCl2 in 4 ml volume within 24 h). Both treatments removed cadmium from liver, spleen, testis and blood with liposomal DMSA exhibiting higher efficacy in mobilizing cadmium not only from whole organs but also from liver proteins. It also resulted in higher excretion of cadmium via urine as compared with free DMSA or saline treatment. Whereas this treatment eliminated significantly higher amounts of cadmium via the fecal route throughout the period examined, free DMSA responded only 48 h after treatment and was less effective. The results suggest mobilization of cadmium from intracellular sites of deposition. However, DMSA in the dose administered (24 mumol/kg i.v.) in either form was ineffective in decorporating cadmium from the kidney, the critical organ in cadmium intoxication.
Srivastava
S
S
Industrial Toxicology Research Centre, Lucknow, India.
Gupta
S
S
Behari
J R
JR
Srivastava
R C
RC
D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics / Q000652:urine; D002105:Cadmium Poisoning / Q000188:drug therapy* / Q000378:metabolism; D004337:Drug Carriers; D007274:Injections, Intraperitoneal; D008081:Liposomes; D008297:Male; D051379:Mice; D004113:Succimer / Q000008:administration & dosage / Q000627:therapeutic use*; D014018:Tissue Distribution
D004337:Drug Carriers; D008081:Liposomes; D002104:Cadmium; D004113:Succimer