[An analysis of the age-related characteristics of the analgesic action of clofelin].
In the experiments on rats of different ages it was found that the analgesic effect of clopheline was stronger in the adult animals as compared with 1-month-old ones. Against the background of the operative trauma (laparotomy) the inversion of the effect occurs, namely clopheline exerts a more potent analgesic effect of clopheline in young animals. Simultaneously in the young animals there is observed suppression of the memory processes based on the nociceptive reinforcement. The potentiation of the analgesic effect of clopheline in 1-month-old animals is followed by an increase of the activity of Na+, K(+)-ATPase in the brain cortex the degree of which (two times) corresponds to the rise of the analgesic effect.
Zlenko
E T
ET
Demchenko
E M
EM
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D017301:Ca(2+) Mg(2+)-ATPase / Q000187:drug effects / Q000378:metabolism; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D008297:Male; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects / Q000378:metabolism
D000700:Analgesics; D017301:Ca(2+) Mg(2+)-ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D003000:Clonidine
Analiz vozrastnykh osobennosteĭ anal'geziruiushchego deĭstviia klofelina.