title: [Ki-67 antigen, a cell cycle and tumor growth marker].
abstract: The Ki-67 antigen is a cell cycle and tumor growth marker, which can be readily detected using immunocytochemistry methods. Ki-67 antigen is present only in the nuclei of cycling cells and is variably expressed as the cell goes through the various phases of the cycle: both the amount and the topographic distribution of Ki-67 antigen vary in a manner which is sufficiently specific to establish the precise cycle phase for each member of a cell population. From G1 through mitosis, the amount of Ki-67 antigen increases steadily: location of the antigen is nucleolar during G1 and both nucleolar and karyoplasmic during G2. The Ki-67 antigen is widely used to estimate the growth fraction of a tumor cell population; in many malignancies, the percentage of Ki-67-positive cells is correlated with parameters reflecting tumor aggressiveness or progression. These findings demonstrate the potential value of the Ki-67 antigen for the cytopathological or histopathological study of tumors, although neither its biochemical structure nor its function have been fully elucidated to date.
authors.affiliation: Laboratoire de Génétique, Histologie, Biologie de la Reproduction, Faculté de Médecine de Grenoble, Domaine de la Merci, La Tronche, France.
authors.forename: D
authors.initials: D
authors.lastname: Seigneurin
authors.forename: P
authors.initials: P
authors.lastname: Guillaud
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000276:immunology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000276:immunology; D003110:Colonic Neoplasms / Q000235:genetics / Q000276:immunology; D005434:Flow Cytometry / Q000379:methods; D016193:G1 Phase; D006801:Humans; D019394:Ki-67 Antigen; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology; D008938:Mitosis / Q000502:physiology*; D009423:Nervous System Neoplasms / Q000235:genetics / Q000276:immunology*; D009687:Nuclear Proteins / Q000032:analysis*; D011990:Receptors, Transferrin / Q000032:analysis; D013936:Thymidine / Q000235:genetics
chemical_list: D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D011990:Receptors, Transferrin; D013936:Thymidine
vernacular_title: L'antigène Ki-67, marqueur du cycle cellulaire et de la prolifération tumorale.