title: Lymphomatoid papulosis followed by large-cell lymphoma: immunophenotypical and genotypical analysis.
abstract: The immunophenotype and genotype of atypical cells in skin and lymph node infiltrates were investigated in a patient with lymphomatoid papulosis (LyP) complicated by anaplastic large-cell lymphoma of the lymph nodes. The large atypical cells in both skin and lymph nodes displayed an almost identical immunophenotype, i.e. CD30+ and CD25+. Southern blot analysis for T-cell receptor beta-chain gene rearrangement revealed an identical gene configuration in DNA extracted from skin and lymph node. Our results strongly support the hypothesis that clonal populations of T cells arising in cutaneous LyP lesions may undergo malignant transformation, spread into regional lymph nodes, and give rise to secondary malignant lymphomas, such as anaplastic large-cell lymphoma.
authors.affiliation: Dermatologische Klinik, Ludwig-Maximilians-Universität, München, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Kaudewitz
authors.forename: H
authors.initials: H
authors.lastname: Herbst
authors.forename: I
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: F
authors.initials: F
authors.lastname: Eckert
authors.forename: O
authors.initials: O
authors.lastname: Braun-Falco
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000502:physiology; D006801:Humans; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008297:Male; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012867:Skin / Q000276:immunology; D012871:Skin Diseases / Q000150:complications* / Q000235:genetics / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen; D015375:Receptors, Interleukin-2; D004247:DNA