TGFSS1 modulates bFGF receptor message expression in cultured adult auditory neurons.
Basic fibroblast growth factor (bFGF) has been shown to have neuronotrophic effects on cultured neurons. Transforming growth factor beta (TGFss1) has been implicated in the modulation of cellular receptors for bFGF in several cell types. In this study, we show that TGFss1 is expressed in cultured adult mouse auditory neurons in response to explanation injury and acts in an autocrine fashion to increase the level of expression of bFGF receptors message in these same neurons. Based on these in-vitro results, we propose that these trophic factors (i.e. TGFss1 and bFGF) play a significant role in the response to injury by the mature auditory system.
Lefebvre
P P
PP
Department of Human Physiology, University of Liège, Belgium.
Staecker
H
H
Weber
T
T
Van de Water
T R
TR
Rogister
B
B
Moonen
G
G
D000818:Animals; D001483:Base Sequence; D016373:DNA, Antisense / Q000378:metabolism; D005724:Ganglia / Q000166:cytology / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010751:Phosphopyruvate Hydratase; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D017468:Receptors, Fibroblast Growth Factor; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016373:DNA, Antisense; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D016212:Transforming Growth Factor beta; D010751:Phosphopyruvate Hydratase