title: Comparative human cellular radiosensitivity: III. Gamma-radiation survival of cultured skin fibroblasts and resting T-lymphocytes from the peripheral blood of the same individual.
abstract: Skin and blood samples were obtained from 34 donors, for whom there was no indication of abnormal radiosensitivity. From these, in 33 cases both fibroblast and T-lymphocyte cultures were obtained and in 26 cases at least three fibroblast and at least two G0 (resting) T-lymphocyte survival assays were possible. Within this set of results, differences in radiosensitivity between donors were significant for fibroblasts but not T-lymphocytes, although the range of radiosensitivity was similar for the two cell types (D 0.90-1.68 Gy for fibroblasts; 1.26-2.15 Gy for T-lymphocytes). Furthermore, there was little evidence for a correlation in radiosensitivity between the two cell types. These results suggest limitations in the predictive value of conventional measurement of cell survival.
authors.affiliation: MRC Cell Mutation Unit, Sussex University, Brighton, UK.
authors.forename: M H
authors.initials: MH
authors.lastname: Green
authors.forename: C F
authors.initials: CF
authors.lastname: Arlett
authors.forename: J
authors.initials: J
authors.lastname: Cole
authors.forename: S A
authors.initials: SA
authors.lastname: Harcourt
authors.forename: A
authors.initials: A
authors.lastname: Priestley
authors.forename: A P
authors.initials: AP
authors.lastname: Waugh
authors.forename: G
authors.initials: G
authors.lastname: Stephens
authors.forename: D M
authors.initials: DM
authors.lastname: Beare
authors.forename: N A
authors.initials: NA
authors.lastname: Brown
authors.forename: G A
authors.initials: GA
authors.lastname: Shun-Shin
mesh_terms: D002470:Cell Survival / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D008297:Male; D008875:Middle Aged; D011836:Radiation Tolerance; D012867:Skin / Q000166:cytology; D013601:T-Lymphocytes / Q000528:radiation effects*
chemical_list: D003037:Cobalt Radioisotopes