title: [Severe hyperlactacidemia in 2 children treated for malignant tumors. Role of vitamin B1].
abstract: Two cases of children treated for malignant tumor and who developed a severe lacticacidosis are reported. A 2 year-old girl and a 8 year-old boy were treated with chemotherapy, irradiation and multiple surgical procedures for nephroblastoma and lymphoma respectively. These two malnourished patients, under exclusive parenteral nutrition for two weeks without vitamin intakes, suddenly developed neurological, cardiovascular and digestive symptoms, associated with cytopenia and lacticacidosis. Injection of vitamin B1 only corrected these abnormalities within a few hours, proving the role of thiamine deficiency as the cause of the symptoms.
authors.affiliation: Unité d'Hémato-Oncologie Pédiatrique, CHRU Purpan, Toulouse.
authors.forename: P
authors.initials: P
authors.lastname: Rouzet
authors.forename: H
authors.initials: H
authors.lastname: Rubie
authors.forename: A
authors.initials: A
authors.lastname: Robert
authors.forename: A
authors.initials: A
authors.lastname: Dutour
authors.forename: J P
authors.initials: JP
authors.lastname: Olives
authors.forename: C
authors.initials: C
authors.lastname: Scipioni
authors.forename: J
authors.initials: J
authors.lastname: Guitard
authors.forename: C
authors.initials: C
authors.lastname: Régnier
mesh_terms: D000140:Acidosis, Lactic / Q000209:etiology*; D002051:Burkitt Lymphoma / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010288:Parenteral Nutrition / Q000009:adverse effects*; D013832:Thiamine Deficiency / Q000209:etiology*; D009396:Wilms Tumor / Q000628:therapy
vernacular_title: Hyperlactacidémie sévère chez deux enfants traités pour tumeur maligne. Rôle de la vitamine B1.