title: [Thymidine kinase as a biological marker in neoplasms of the lung and mediastinum].
abstract: Thymidine kinase (TK) is a biological marker recently used in diagnosis and monitoring of pulmonary and mediastinal malignant neoplasms. Authors report more recent clinical evidences of literature and, in the meanwhile, they report their personal experiences about a 20 patients group suffering of lung cancer and Hodgkin disease. Their study demonstrates a good sensitivity of TK as biological marker of SCLC and a lower sensitivity in case of NSCLC and Hodgkin disease. It has been possible to contribute to establishment of normal range values, on account of 10 healthy volunteer group blood sample assays.
authors.affiliation: II Facoltà di Medicina e Chirurgia, Cattedra di Malattie dell'Apparato Respiratorio, Università degli Studi di Napoli.
authors.forename: F
authors.initials: F
authors.lastname: De Blasio
authors.forename: M
authors.initials: M
authors.lastname: Alonzo
authors.forename: S
authors.initials: S
authors.lastname: Zofra
authors.forename: R
authors.initials: R
authors.lastname: De Colle
authors.forename: L
authors.initials: L
authors.lastname: Romano
authors.forename: A
authors.initials: A
authors.lastname: Pezza
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis*; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D004796:Clinical Enzyme Tests / Q000379:methods; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013937:Thymidine Kinase / Q000097:blood*
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D013937:Thymidine Kinase
vernacular_title: La timidina-kinasi come marcatore biologico delle neoplasie del polmone e del mediastino.