The 90-kDa heat shock protein protects mammalian cells from thermal stress but not from viral infection.
Using an anti-sense RNA approach, a mouse cell line containing dramatically reduced levels of the 90-kDa heat shock protein (hsp90) has been isolated. This line shows reduced growth at mildly elevated temperatures and reduced survival at highly elevated temperatures but is no more sensitive to herpes simplex virus infection than the parental cells. This is the first direct evidence of a role for an individual mammalian hsp in thermotolerance and suggests that individual hsps may be of different value in the response to various types of stress.
Bansal
G S
GS
Department of Biochemistry, University College and Middlesex School of Medicine, London.
Norton
P M
PM
Latchman
D S
DS
D000818:Animals; D015153:Blotting, Western; D002455:Cell Division; D002470:Cell Survival / Q000502:physiology; D006360:Heat-Shock Proteins / Q000502:physiology*; D006358:Hot Temperature; D007700:Kinetics; D007739:L Cells; D051379:Mice; D016372:RNA, Antisense; D018139:Simplexvirus / Q000502:physiology*; D014779:Virus Replication
D006360:Heat-Shock Proteins; D016372:RNA, Antisense