Potential-dependent Ca channels of neurons in the mollusc Lymnaea stagnalis in aging: effect of norepinephrine.
During aging changes occur in the function of potential-dependent Ca channels of plasmic membrane of identified neurons in the mollusc Lymnaea stagnalis, i.e. the value of Ca inward current of neurons in old vs. adult molluscs was much higher at holding potential -50 - -30 mV. When held at -20 mV, the amplitude of Ca current decreased in the neurons of old molluscs, but continued to increase in those of adult molluscs. Various populations of potential-dependent Ca channels are assumed to have irregular age-related changes. The norepinephrine-induced inhibition of Ca current was more significant in old vs. adult molluscan neurons.
Frolkis
V V
VV
Institute of Gerontology, AMS USSR, Kiev.
Martynenko
O A
OA
Timchenko
A N
AN
D000375:Aging / Q000502:physiology; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D004594:Electrophysiology; D008195:Lymnaea; D009474:Neurons / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology*
D015220:Calcium Channels; D009638:Norepinephrine