Peripheral opioid secretory pattern in anorexia nervosa.
The peripheral secretion of endogenous opioids was studied in 10 women with restrictive anorexia nervosa and 10 age- and sex-matched healthy controls. The circadian rhythm of beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH), and their responses to the administration of corticotropin releasing hormone (CRH, 1 micrograms/kg body weight, i.v.), clonidine (150 microgram, i.v.), domperidone (10 mg, i.v.), and 5-hydroxytryptophan (5-HTP, 200 mg, p.o.) were examined in patients and controls. The results revealed increased nocturnal secretion of beta-EP and diurnal-nocturnal secretion of beta-LPH with loss of circadian rhythmicity of both peptides, normal response to CRH stimulation, blunted response to clonidine and domperidine, and normal beta-EP and blunted beta-LPH response to 5-HTP stimulation. The data suggest a complex alteration of peripheral opioids and of central aminergic mechanisms that regulate proopiomelanocortin-derived peptide secretion and eating behavior.
Brambilla
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F
Psychoneuroendocrine Center, Ospedale Psichiatrico Pini, Milan, Italy.
Ferrari
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E
Petraglia
F
F
Facchinetti
F
F
Catalano
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M
Genazzani
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AR
D006916:5-Hydroxytryptophan; D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000175:diagnosis; D001835:Body Weight / Q000502:physiology; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D003000:Clonidine; D003346:Corticotropin-Releasing Hormone; D004294:Domperidone; D004723:Endorphins / Q000097:blood*; D005260:Female; D006801:Humans; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects / Q000502:physiology; D001615:beta-Endorphin / Q000097:blood; D008083:beta-Lipotropin / Q000097:blood
D004723:Endorphins; D011957:Receptors, Opioid; D004294:Domperidone; D001615:beta-Endorphin; D003346:Corticotropin-Releasing Hormone; D008083:beta-Lipotropin; D006916:5-Hydroxytryptophan; D003000:Clonidine