title: In vivo administration of TNF-alpha prevents EMC-M virus induced viral encephalitis.
abstract: EMC-M virus causes a monophasic paralytic syndrome characterized by encephalitic lesions in the brain and patchy demyelinating lesions in the spinal cord and nerve roots of BALB/c mice. Since the replication of EMC virus in vitro is inhibited by tumor necrosis factor (TNF)-alpha we have studied the effect of in vivo administration of this cytokine on the acute disease. Our studies show that periodic administration of TNF-alpha to animals infected with EMC-M reduces viral titers in the brain, and decreases the degree of clinical paralysis and the severity of the inflammatory lesions in the brain.
authors.affiliation: Department of Neurology, College of Medicine, University of Vermont, Burlington 05405.
authors.forename: S
authors.initials: S
authors.lastname: Sriram
authors.forename: D J
authors.initials: DJ
authors.lastname: Topham
authors.forename: L
authors.initials: L
authors.lastname: Carroll
authors.forename: M
authors.initials: M
authors.lastname: Shenoy
authors.forename: A
authors.initials: A
authors.lastname: Adesina
authors.forename: J E
authors.initials: JE
authors.lastname: Craighead
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000382:microbiology; D001921:Brain / Q000382:microbiology; D004660:Encephalitis / Q000517:prevention & control*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010849:Picornaviridae / Q000187:drug effects; D010850:Picornaviridae Infections / Q000382:microbiology / Q000517:prevention & control*; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D014409:Tumor Necrosis Factor-alpha