D-alanine inhibits methamphetamine-induced hyperactivity in rats.
Bilateral intracerebroventricular injection of D-alanine (200-600 micrograms/rat) antagonized the ability of methamphetamine (1.0 mg/kg s.c.) to induce locomotor stimulation in the rat. In contrast, L-alanine (600 micrograms/rat) failed to affect the behavioral change induced by methamphetamine. The stereoselectivity parallels the potency of these amino acids as agonists for the strychnine-insensitive glycine binding site within the NMDA receptor complex. These results support the view that reduced excitatory amino acidergic neurotransmission may be involved in methamphetamine-induced hyperactivity.
Hashimoto
A
A
Division of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Nishikawa
T
T
Oka
T
T
Takahashi
K
K
D000409:Alanine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D007276:Injections, Intraventricular; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D017981:Receptors, Neurotransmitter / Q000187:drug effects; D013237:Stereoisomerism; D013239:Stereotyped Behavior / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology
D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D008694:Methamphetamine; D013331:Strychnine; D000409:Alanine