Phosphoinositide signalling system in red blood cells of patients with hereditary spherocytosis.
Hereditary spherocytosis (HS) is characterised with many deviations of red blood cells properties. We investigated a group of 14 patients with mild HS, 7 of whom were splenectomised. We found changes in the content and/or turnover of polyphosphoinositides and phosphatidic acid accompanied by the higher generation of inositol 1,4,5-trisphosphate. We suggest that the activation of the phosphoinositide signalling system may be crucial for the manifestation of HS.
Strunecká
A
A
Department of Physiology and Developmental Biology, Faculty of Sciences, Charles University, Prague, Czechoslovakia.
Krpejsová
L
L
Kmonícková
E
E
Hrůsová
H
H
Jakoubková
H
H
Marík
T
T
Brabec
V
V
D002118:Calcium / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000097:blood; D010710:Phosphates / Q000097:blood; D010712:Phosphatidic Acids / Q000097:blood; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000097:blood* / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction; D013103:Spherocytosis, Hereditary / Q000097:blood*; D013156:Splenectomy
D010710:Phosphates; D010712:Phosphatidic Acids; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C037178:phosphatidylinositol 4-phosphate; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium