title: High-dose intravenous IgG treatment and renal function.
abstract: In an open trial of high dose intravenous IgG (IVIG) treatment in nephrotic patients with glomerulonephritis, the first six patients so far studied showed a transient rise in plasma creatinine. This increase was not associated with any symptoms and the urinary deposit remained unchanged. Two other patients with pre-existing renal impairment but without nephrotic syndrome had a transient and reversible rise in plasma creatinine immediately after IVIG. These observations suggest that high-dose IVIG infusion can produce short-lived disturbances in renal function in patients with kidney diseases.
authors.affiliation: Division of Nephrology, Hôpital Cantonal Universitaire, Geneva, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Schifferli
authors.forename: M
authors.initials: M
authors.lastname: Leski
authors.forename: H
authors.initials: H
authors.lastname: Favre
authors.forename: P
authors.initials: P
authors.lastname: Imbach
authors.forename: U
authors.initials: U
authors.lastname: Nydegger
authors.forename: K
authors.initials: K
authors.lastname: Davies
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy*; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage* / Q000627:therapeutic use; D016756:Immunoglobulins, Intravenous; D007262:Infusions, Intravenous; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000188:drug therapy
chemical_list: D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D003404:Creatinine