[Correction by natural adaptogens of hormonal-metabolic status disorders in rats during the development of adaptation syndrome using functional tests with dexamethasone and ACTH].
Rats exposed to stress by fixation develop a complex of hormonal metabolic homeostasis disturbances (as evidenced by changed levels of ACTH, insulin, 11-HOCS, urea, glucose). One of the major mechanisms of these disorders in reduced hypothalamus sensitivity to regulatory signals and exhausted adrenocortical functional activity, developing at the stages of anxiety and exhaustion of the adaptation syndrome, respectively, and detectable by functional tests with dexamethasone and ACTH. Administration of natural adaptogens (Scutellaria baicalensis extract and its active principle, baikalin flavonoid) was conducive to normalization of the majority of the examined parameters whatever the direction of changes.
Udintsev
S N
SN
Krylova
S G
SG
Konovalova
O N
ON
D000222:Adaptation, Physiological; D000324:Adrenocorticotropic Hormone; D000818:Animals; D003907:Dexamethasone; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology / Q000503:physiopathology; D051381:Rats; D013312:Stress, Physiological / Q000188:drug therapy / Q000503:physiopathology*
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C038044:baicalin; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone
Korrektsiia adaptogenami prirodnogo proiskhozhdeniia narusheniĭ gormonal'no-metabolicheskogo statusa organizma krys v protsesse razvitiia adaptatsionnogo sindroma pri provedenii funktsional'nykh prob s deksametazonom i AKTG.