title: Antitumor organometallics. II. Inhibitory effects of two diphenyl-antimony (III) dithiophosphorus derivatives on in vitro and in vivo Ehrlich ascites tumor.
abstract: (Diphenylphosphinodithioato) diphenylantimony (III), Ph2SbS2PPh2 (1) and (diisopropylphosphorodithioato) diphenylantimony(III), Ph2SbS2P(OPri)2 (2) were tested in vivo in male AKR mice and in vitro against Ehrlich ascites tumor cells. Both compounds exhibited dose-dependent inhibitory effects on in vivo tumor growth and on in vitro cell proliferation, cell viability, respiration and protein synthesis. The activities of some enzymes involved in energetic metabolism (Ca-ATPase, LDH, G6Pase) were exacerbated in vitro. The inhibitory effects could be related to the imbalance between ATP-producing and ATP-consuming processes in Ehrlich ascites tumor cells and also to their cell-cycle specificities.
authors.affiliation: Biochemistry Department, Agronomic Institute of Cluj-Napoca, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Socaciu
authors.forename: A
authors.initials: A
authors.lastname: Bara
authors.forename: C
authors.initials: C
authors.lastname: Silvestru
authors.forename: I
authors.initials: I
authors.lastname: Haiduc
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D004341:Drug Evaluation; D005952:Glucose-6-Phosphatase / Q000187:drug effects; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000187:drug effects; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D009946:Organothiophosphorus Compounds / Q000737:chemistry; D009195:Peroxidase / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009946:Organothiophosphorus Compounds; C064871:diphenylantimony diphenyldithiophosphinate; C064870:diphenylantimony diisopropyldithiophosphate; D007770:L-Lactate Dehydrogenase; D009195:Peroxidase; D005952:Glucose-6-Phosphatase; D000252:Calcium-Transporting ATPases