[Toxic reduction and superior therapeutic effects on peritoneal carcinomatosis of etoposide particles suspended in oil in mice].
Two dosage forms of etoposide diluted by saline solution (Etp-sol) and etoposide particles suspended in oil (Etp-oil) were examined for the toxicity and therapeutic effects when injected intraperitoneally (ip) in mice. The 50% lethal dose (LD50) values for two weeks observation were 135 mg/kg in Etp-oil and 108 mg/kg in Etp-sol. Two days after intraperitoneal transplantation of 10(6) cells/mouse of P388 leukemia to CDF1 male mice, etoposide was injected intraperitoneally in the form of Etp-oil or Etp-sol. In the mice receiving 20mg/kg of etoposide, 11 of 19 mice given Etp-oil and 3 of 20 given Etp-sol survived to day 60. In the mice receiving 80 mg/kg of etoposide, 1 in 20 treated with Etp-oil and 8 of 20 treated with Etp-sol died from by the toxicity.
Lee
M
M
First Dept. of Surgery, Kyoto Prefectural University of Medicine.
Takahashi
T
T
Hagiwara
A
A
Iwamoto
A
A
Shimotuma
M
M
Yoneyama
C
C
Itoh
M
M
Sasabe
T
T
Sakakura
C
C
Shobayashi
S
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003692:Delayed-Action Preparations; D005047:Etoposide / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D007263:Infusions, Parenteral; D007459:Iodized Oil / Q000008:administration & dosage*; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000150:complications* / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D003692:Delayed-Action Preparations; D005047:Etoposide; D007459:Iodized Oil