[Evaluation of the vaccination of 3-month-old infants with Haemophilus influenzae type B (Hi b) capsular polysaccharide conjugated to tetanus protein (PRT-T) Pediatric Group of the Lyon Region].
Haemophilus influenzae type b (Hi b) is responsible for severe invasive infections, particularly meningitis, in children under 5 years of age, with the greatest frequency between 6 and 18 months. The antigenicity of Hib is related to its capsular polysaccharide (polyribosyl-ribitol-phosphate or PRP) which is at the origin of the production of bactericide anti-PRP antibodies. Vaccine using PRP alone have been shown to be well tolerated and immunogenic, but only in children above 2 years of age. We vaccinated 365 infants starting at the age of 3 months with a vaccine using a PRP-tetanus toxoid conjugate (PRP-T), coupled with the DTP pertussis vaccine. Local and general tolerance was found to be very good. Quantitative serum antibody measurements showed excellent immunogenicity. None of the vaccinated infants presented an invasive Hib infection. It therefore appears that early systematic vaccination of infants with PRP-T vaccine should be encouraged.
Langue
J
J
Pasteur Mérieux, Marnes-la-Coquette, France.
Fritzell
B
B
Preziozi
M P
MP
Houmeau
P
P
D000906:Antibodies / Q000032:analysis; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011134:Polysaccharides / Q000008:administration & dosage / Q000276:immunology*; D015531:Radioimmunoprecipitation Assay; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination
D000906:Antibodies; D011134:Polysaccharides; D013745:Tetanus Toxoid; C008984:polyribitol phosphate
Evaluation de la vaccination des enfants de 3 mois avec le polyoside capsulaire d'Haemophilus influenzae type B (Hi b) conjugué à la protéine tétanique (PRT-T). Groupement des pédiatres de la région de Lyon.