Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study.
The normal counterparts of the B cells found in hairy cell leukemia (HCL) are not known. We report here a detailed morphological, cytochemical, immunological and molecular analysis of a patient with B-cell chronic lymphocytic leukemia (B-CLL) who later in the course of his disease developed hairy cell leukemia. We speculate that hairy cell transformation of B-CLL might be related to an in vivo protein kinase C mediated cellular activation of B-CLL cells.
Duchayne
E
E
Laboratoire de Cytologie et Cytogénétique, CRTS, Purpan, Toulouse, France.
Delsol
G
G
Kuhlein
E
E
Klein
B
B
Zhang
X G
XG
Attal
M
M
Cassard
G
G
Laurent
G
G
D015139:Blotting, Southern; D002872:Chromosome Deletion; D002883:Chromosomes, Human, Pair 14; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D007143:Immunoglobulin Heavy Chains