title: PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report.
abstract: The utility of the peripheral type benzodiazepine site ligand 11C-PK 11195, for imaging human glioma in conjunction with Positron Emission Tomography, relies on a high specific binding of the tracer to tumoral peripheral type benzodiazepines sites. In a patient with glioblastoma, we found that 11C-PK 11195 binding was two-fold higher in the tumor than in normal gray matter and that 30% of tumoral binding could be displaced by a large excess of unlabeled drug. These findings suggest that tumoral retention of the ligand is due, in part, to specific binding.
authors.affiliation: INSERM U. 334 Service Hospitalier Frédéric Joliot, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Pappata
authors.forename: P
authors.initials: P
authors.lastname: Cornu
authors.forename: Y
authors.initials: Y
authors.lastname: Samson
authors.forename: C
authors.initials: C
authors.lastname: Prenant
authors.forename: J
authors.initials: J
authors.lastname: Benavides
authors.forename: B
authors.initials: B
authors.lastname: Scatton
authors.forename: C
authors.initials: C
authors.lastname: Crouzel
authors.forename: J J
authors.initials: JJ
authors.lastname: Hauw
authors.forename: A
authors.initials: A
authors.lastname: Syrota
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D007546:Isoquinolines; D008297:Male; D011963:Receptors, GABA-A / Q000032:analysis*; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195