Chronic electroconvulsive treatment counteracts cortical beta-adrenoceptor upregulation induced by morphine abstinence.
Morphine treatment (20 mg/kg for 7 consecutive days) did not affect the density of [3H]dihydroalprenolol ([3H]DHA) binding sites in the cortical membranes of the rat, but during naloxone-precipitated abstinence syndrome the density of these sites increased. Electroconvulsive treatment for 6 days, which by itself decreased the density of [3H]DHA binding sites, prevented the increase.
Vetulani
J
J
Department of Biochemistry, Polish Academy of Sciences, Kraków.
Antkiewicz-Michaluk
L
L
Michaluk
J
J
Rokosz-Pelc
A
A
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D004082:Dihydroalprenolol; D004565:Electroconvulsive Therapy; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D015854:Up-Regulation / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D009270:Naloxone; D004082:Dihydroalprenolol; D009020:Morphine