Ibuprofen therapy in experimental porcine gram-negative septic shock.
To evaluate the effects of ibuprofen on gram-negative septic shock, immature piglets were subjected to fecal-Escherichia coli peritonitis. Group I (n = 5) received a 12.5 mg/kg bolus of ibuprofen in 0.9% benzyl alcohol, followed by a continuous infusion of 6.25 mg/kg/h. Group II (n = 5) received the vehicle, benzyl alcohol, and Group III (n = 5) received lactated Ringer's solution. Mean survival times among the three groups were not significantly different. Ibuprofen-treated animals had a mean survival time (+/- S.E.M.) of 17.1 +/- 2 h vs. 19.2 +/- 2.4 h in the benzyl alcohol group and 15.7 +/- 2.7 h in the animals receiving lactated Ringer's solution. Thromboxane B2 levels were not significantly different in the treatment vs. non-treatment groups while 6-keto-PGF1a levels were significantly lower in the ibuprofen-treated animals. Neutropenia and thrombocytopenia were not prevented by treatment with ibuprofen.
Griffin
M P
MP
Department of Pediatrics, University of Texas Medical Branch, Galveston.
Gore
D C
DC
Lobe
T E
TE
Flynn
J F
JF
Traber
D L
DL
Herndon
D N
DN
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D004927:Escherichia coli Infections / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007052:Ibuprofen / Q000627:therapeutic use*; D007958:Leukocyte Count; D010538:Peritonitis / Q000188:drug therapy; D010976:Platelet Count; D011652:Pulmonary Circulation / Q000187:drug effects; D012772:Shock, Septic / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D013552:Swine; D013929:Thromboxane B2 / Q000097:blood; D014655:Vascular Resistance / Q000187:drug effects
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D007052:Ibuprofen