A new cyclitol derivative influences inositol metabolism in Neurospora crassa.
Cyclitol derivatives have been synthesized and screened for growth inhibitory effect upon prokaryotic and eukaryotic organisms. One derivative, (2S,3R,5R)-3-azido-2-benzoyloxy-5-hydroxycyclohexanone, was studied in detail: it has no effect upon bacteria, but it is inhibitory to Neurospora crassa. In Neurospora crassa it increased the amount of myo-inositol-1-phosphate synthase and inhibited the activity of myo-inositol-monophosphatase. The enhanced synthesis of myo-inositol-1-phosphate synthase was the consequence of lowering the intracellular inositol concentration. Li+ treatment of Neurospora crassa has effects similar to those of P.I.-658.
Szabó
G
G
Department of Biology, University Medical School, Debrecen, Hungary.
Schablik
M
M
Kiss
A
A
Koncz
C
C
Bognár
R
R
Pelyvás
I
I
Sztaricskai
F
F
D002455:Cell Division / Q000187:drug effects; D003512:Cyclohexanones / Q000494:pharmacology*; D007294:Inositol / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology; D007296:Myo-Inositol-1-Phosphate Synthase / Q000378:metabolism; D009492:Neurospora crassa / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors
D003512:Cyclohexanones; D007294:Inositol; C067895:MI 658; D008094:Lithium; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase; D007296:Myo-Inositol-1-Phosphate Synthase