In-vitro dissolution properties of indomethacin extended-release capsules.
In-vitro dissolution properties of indomethacin extended-release capsules, from samples available on the Japanese market, have been investigated using a continuous flow, column-type dissolution apparatus and the results compared with those obtained by the paddle and the rotating basket methods. A plot of the percent of drug dissolved against the square root of time gave a straight line with the flow-through method but not with the paddle or the rotating basket methods. The results suggest an advantage of the flow-through method over the other two methods when extended-release products are tested by in-vitro dissolution.
Komuro
T
T
Drug Division, National Institute of Hygienic Sciences, Osaka Branch, Japan.
Yomota
C
C
Kimura
T
T
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D007213:Indomethacin; D012996:Solutions
D003692:Delayed-Action Preparations; D012996:Solutions; D007213:Indomethacin