["Dynamic" component of carotid artery stenosis in patients with cerebrovascular disorders].
Nifedipine is shown to abolish contraction of the vessel at the site of the internal carotid artery stenosis induced by a cold test. It can furthermore produce a direct 5-40% reduction of the stenosis, the effect being dependent both on the drug plasma level and the ability to rise such levels of prostacyclin. In some patients there is a possibility of nifedipine contrary action when it promotes stenosis (up to 5-30% increase) and leads to disturbances of cerebral circulation. Consequently, to make optimal therapeutic measures in relevant patients nifedipine should be tried for stenosis-directed action.
Gabrielian
E S
ES
Akopov
S E
SE
Grigorian
G S
GS
Tunian
Iu S
IuS
D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000150:complications* / Q000188:drug therapy; D002343:Carotid Artery, Internal / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D009543:Nifedipine / Q000627:therapeutic use*; D013035:Spasm / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D014654:Vascular Patency / Q000187:drug effects / Q000502:physiology
D009543:Nifedipine
O "dinamicheskom" komponente stenozov sonnykh arteriĭ u bol'nykh s tserebrovaskuliarnymi zabolevaniiami.