title: Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures.
abstract: We report a patient with a progressive, predominantly sensory neuropathy and a IgM kappa M-protein that binds to Schmidt-Lantermann incisures. A sural nerve biopsy showed primary axonal damage and IgM deposits at Schmidt-Lantermann incisures were seen by direct immunoperoxidase. Serum from the patient injected into rat sciatic nerve reacts with the incisures as with those in the patient's nerve. The IgM kappa M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa. Peripheral neuropathy may be related to the M-protein, which had immunocytochemical reactivity not previously described for patients with polyneuropathy and IgM monoclonal gammopathy.
authors.affiliation: Department of Neurology, University of Milan, Istituto Scientifico S. Raffaele, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Quattrini
authors.forename: R
authors.initials: R
authors.lastname: Nemni
authors.forename: R
authors.initials: R
authors.lastname: Fazio
authors.forename: S
authors.initials: S
authors.lastname: Iannaccone
authors.forename: I
authors.initials: I
authors.lastname: Lorenzetti
authors.forename: F
authors.initials: F
authors.lastname: Grassi
authors.forename: N
authors.initials: N
authors.lastname: Canal
mesh_terms: D001369:Axons / Q000473:pathology*; D001798:Blood Proteins / Q000276:immunology*; D002809:Chondroitin Sulfates / Q000032:analysis; D006801:Humans; D015151:Immunoblotting; D007075:Immunoglobulin M / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D007136:Immunoglobulins; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology
chemical_list: D001798:Blood Proteins; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins; C009823:M-proteins (Myeloma); D002809:Chondroitin Sulfates