Association of Ki-ras mutation with differentiation and tumor-formation pathways in colorectal carcinoma.
The occurrence of a point mutation on the 12th and 13th codons of the Ki-ras oncogene has been investigated in 99 colorectal carcinomas in relation to 3 histological parameters: extent of differentiation, occurrence of a mucinous component within the tumor, and presence of peripheral adenomatous polyp remnants. The mutation frequency increased with each parameter: from 13% (2/15) to 44% (37/84) with differentiation, from 33% (26/79) to 65% (13/20) with mucinous character, and from 27% (15/56) to 56% (24/43) with the presence of polyp remnants. The frequency was highest in well-differentiated mucinous tumors with adenomatous remnants 83% (5/6). We suggest that Ki-ras mutation is preferentially involved in carcinomas that have developed from adenoma and that the mutation preserves differentiation and mucin secretion in these cancer cells.
Laurent-Puig
P
P
Section de Biologie, Institut Curie, Paris, France.
Olschwang
S
S
Delattre
O
O
Validire
P
P
Melot
T
T
Mosseri
V
V
Salmon
R J
RJ
Thomas
G
G
D002288:Adenocarcinoma, Mucinous / Q000235:genetics / Q000473:pathology; D001483:Base Sequence; D003062:Codon / Q000235:genetics*; D003111:Colonic Polyps / Q000235:genetics / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*
D003062:Codon