Antibodies to seven rotavirus serotypes in cord sera, maternal sera, and colostrum of German women.
Forty percent of colostrum samples from German women showed neutralizing antibody titers of greater than or equal to 50 to rotavirus (RV) serotypes 1, 3, 4, and 6. Antibody to serotypes 2, 8, and 9 was less prevalent. Titers are, however, too low to indicate an important effect of colostrum on the RV vaccine take rate. On the other hand, about 50% of the cord serum samples showed high neutralizing-antibody titers to serotypes 1, 3, and 4, which could interfere with the take rate of RV vaccines based on these serotypes in very young infants.
Brüssow
H
H
Nestlé Research Centre, Nestec Ltd., Lausanne, Switzerland.
Sidoti
J
J
Lerner
L
L
Rahim
H
H
Eckstein
W
W
Werchau
H
H
Mietens
C
C
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis / Q000097:blood*; D003126:Colostrum / Q000737:chemistry / Q000382:microbiology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology / Q000382:microbiology*; D005858:Germany; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D011247:Pregnancy; D012401:Rotavirus / Q000145:classification / Q000276:immunology*
D000914:Antibodies, Viral