title: Histologic analysis of a retrieved hydroxyapatite-coated femoral prosthesis.
abstract: A hydroxyapatite-coated hip hemi-prosthesis was retrieved from a 98-year-old osteoporotic woman 12 weeks after implantation. Histologic analysis revealed bone and fibrous tissue almost evenly distributed around the surface of the implant circumference. Quantitative histologic analysis showed that 48% of the hydroxyapatite surface was covered by bone. Fibrous tissue covered 30% of the prosthetic surface, and 20% of the surface had no tissue coverage. Scanning electron microscopy showed direct contact without any clear boundary between the newly formed bone and the hydroxyapatite ceramic.
authors.affiliation: Department of Orthopaedic Surgery, Hilleroed Hospital, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Søballe
authors.forename: K
authors.initials: K
authors.lastname: Gotfredsen
authors.forename: H
authors.initials: H
authors.lastname: Brockstedt-Rasmussen
authors.forename: P T
authors.initials: PT
authors.lastname: Nielsen
authors.forename: K
authors.initials: K
authors.lastname: Rechnagel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001842:Bone and Bones / Q000648:ultrastructure*; D003238:Connective Tissue / Q000473:pathology*; D017886:Durapatite; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D006882:Hydroxyapatites; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D012086:Reoperation; D013499:Surface Properties
chemical_list: D006882:Hydroxyapatites; D017886:Durapatite