title: Effects of alprazolam on fear-related behavioral, hormonal, and catecholamine responses in infant rhesus monkeys.
abstract: We tested the effects of various doses of the triazolobenzodiazepine alprazolam on behavioral, hormonal, and neurochemical responses of infant rhesus monkeys under three conditions of separation from their mothers: alone, in the presence of a human who stared at them, and in the presence of a human who avoided eye contact. Alprazolam affected stress-induced responses in all three of these classes. Unrelated to its effects on the stress response, alprazolam appears to reduce the function of brain dopamine systems.
authors.affiliation: Department of Psychiatry, University of Wisconsin School of Medicine, Madison 53792.
authors.forename: N H
authors.initials: NH
authors.lastname: Kalin
authors.forename: S E
authors.initials: SE
authors.lastname: Shelton
authors.forename: J G
authors.initials: JG
authors.lastname: Turner
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000525:Alprazolam / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002395:Catecholamines / Q000134:cerebrospinal fluid; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D005239:Fear / Q000187:drug effects*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D011863:Radioimmunoassay
chemical_list: D002395:Catecholamines; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone; D000525:Alprazolam