Developmentally controlled genomic rearrangements in ciliated protozoa.
The ciliated protozoa undergo an extensive genome reorganization during the course of forming a transcriptionally active macronucleus. The process includes numerous chromosome fragmentation and DNA breakage and rejoining events. Recent work indicates that transposable elements play a role in the process.
Klobutcher
L A
LA
Department of Biochemistry, University of Connecticut Health Center, Farmington 06030.
Jahn
C L
CL
D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000648:ultrastructure; D002875:Chromosomes / Q000648:ultrastructure; D016798:Ciliophora / Q000235:genetics / Q000254:growth & development*; D016384:Consensus Sequence; D004251:DNA Transposable Elements; D016054:DNA, Protozoan / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000235:genetics; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
D004251:DNA Transposable Elements; D016054:DNA, Protozoan; D015800:Protozoan Proteins