Effects of age-dependent or liposome-induced alterations in the phospholipid composition on sphingomyelin biosynthesis in rat liver microsomal and plasma membranes.
1. The effects of age-dependent or liposome-induced alterations in the phospholipid composition of rat liver plasma and microsomal membranes on the phosphatidylethanolamine:ceramide-phosphoethanolamine (PE:Cer-PEt) and phosphatidylcholine:ceramide-phosphocholine (PC:Cer-PCh) transferase activities were studied. 2. In all cases under study the PE:Cer-PEt transferase activity was found to be several times higher than that of PC:Cer-PCh transferase in both plasma and microsomal rat liver membranes. 3. The presence of phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) in plasma membranes was observed to enhance the PE:Cer-PEt transferase activity, while phosphatidylserine (PS) inhibited it.
Petkova
D H
DH
Central Laboratory of Biophysics, Bulgarian Academy of Sciences, Sofia.
Nikolova
M N
MN
Kochlukova
S E
SE
Koumanov
K S
KS
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D007425:Intracellular Membranes / Q000378:metabolism; D008081:Liposomes; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology* / Q000648:ultrastructure; D010743:Phospholipids / Q000502:physiology*; D010770:Phosphotransferases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013109:Sphingomyelins / Q000096:biosynthesis*; D017855:Transferases (Other Substituted Phosphate Groups)
D008081:Liposomes; D010743:Phospholipids; D013109:Sphingomyelins; D010770:Phosphotransferases; D017855:Transferases (Other Substituted Phosphate Groups); C070186:phosphatidylcholine-ceramide phosphocholine transferase; C070185:phosphatidylethanolamine-ceramide phosphoethanolamine transferase; C019863:ceramide cholinephosphotransferase