Clinical implications of basic neuroscience research. I: Protein kinases, ionic channels, and genes.
Clinical implications of three areas of basic neuroscience research are described in this review paper. These areas include: (1) the discovery of protein kinase C and its implications for diabetic neuropathy, (2) analysis of single ionic channels and the basis of Lambert-Eaton myasthenic syndrome and cystic fibrosis, and (3) the cloning of genes for Duchenne muscular dystrophy and cystic fibrosis and new approaches to the treatment of these diseases.
Barry
S R
SR
Department of Physical Medicine & Rehabilitation, University Hospital, Ann Arbor, MI 48109-0042.
D000818:Animals; D015220:Calcium Channels / Q000235:genetics; D003550:Cystic Fibrosis / Q000201:enzymology / Q000235:genetics*; D003929:Diabetic Neuropathies / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000235:genetics*; D011494:Protein Kinases / Q000378:metabolism*
D015220:Calcium Channels; D011494:Protein Kinases