Congenital hydrocephalus in suckling hamsters caused by transplacental infection with parainfluenza virus type 3.
The possible occurrence of congenital hydrocephalus by viral infection of the mother was examined by inoculating pregnant hamsters intravenously with parainfluenza virus type 3 (PIV-3). We could produce congenital hydrocephalus in littermates born to a mother which had been inoculated into the left cervical vein on the 14th day of pregnancy. This result may indicate that the virus could pass through the placenta to arrive at the fetus, and infect the central nervous system.
Takano
T
T
Department of Pediatrics, Shiga University of Medical Science, Ohtsu, Japan.
Ohno
M
M
Yamano
T
T
Shimada
M
M
D000818:Animals; D000833:Animals, Suckling; D001921:Brain / Q000473:pathology; D006224:Cricetinae; D005260:Female; D006849:Hydrocephalus / Q000382:microbiology* / Q000473:pathology; D008431:Maternal-Fetal Exchange; D008647:Mesocricetus; D010224:Parainfluenza Virus 3, Human; D018184:Paramyxoviridae Infections / Q000150:complications*; D010920:Placenta / Q000382:microbiology*; D011247:Pregnancy