title: A lipophilic complex with 186Re/188Re incorporated in liposomes suitable for radiotherapy.
abstract: Liposomes with a 70 nm diameter were made by the detergent removal technique on a gel filtration column. The complex oxodichloroethoxy-bis-(triphenylphosphine)rhenium(V)=(Rephos) was irradiated by neutrons in the reactor at PSI. 45 +/ 5% of the radioactive complex was incorporated into the bilayer of the lipsomes during the liposome formation. The stablility of these radioactive liposomes was tested by dialysis: a loss of 40% of the radioactivity identified as perrhenate was observed after 8 days. Addition of the antioxidant ascorbic acid diminished the loss to 20%. Such liposomes carrying the lipophilic radioactive Re-complex can potentially be used in beta-radiotherapy. The gamma-lines of the two rhenium isotopes are helpful for localizing them in therapy controls by a gamma-camera, a big advantage compared to other nuclides proposed for therapy (e.g. 90Yttrium).
authors.affiliation: Paul Scherrer Institute (PSI), Villigen PSI, Department of Pharmacy, Zrich, Switzerland.
authors.forename: U
authors.initials: U
authors.lastname: Häfeli
authors.forename: L X
authors.initials: LX
authors.lastname: Tiefenauer
authors.forename: P A
authors.initials: PA
authors.lastname: Schbiger
authors.forename: H G
authors.initials: HG
authors.lastname: Weder
mesh_terms: D007553:Isotope Labeling; D008081:Liposomes / Q000138:chemical synthesis*; D011868:Radioisotopes; D012211:Rhenium
chemical_list: D008081:Liposomes; D011868:Radioisotopes; D012211:Rhenium