Bilateral mixed germ cell sex-cord stroma tumour in a young adult woman. Case report.
The first Scandinavian case of mixed germ cell-sex cord stroma tumour is presented. The tumour occurred in an anatomically and genetically normal young adult woman. The tumour exhibited mainly two histopathological patterns. Larger parts consisted of abundant connective tissue containing cellular nests with numerous germ cells and a few sex cord derivatives. Minor parts showed a tubular pattern composed of tubules of sex cord elements containing scattered germ cells. Immunohistochemical stains for cytokeratin, vimentin, placental alkaline phosphatase and various other substances were all negative. This case is in addition the first reported case where the tumour was bilateral. The second tumour occurred in the contralateral ovary three years after excision of the first one and showed the same histopathological pattern as in the predominant part of the first.
Jacobsen
G K
GK
Department of Pathology, Gentofte Hospitals, University of Copenhagen, Denmark.
Braendstrup
O
O
Talerman
A
A
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology*