ACTH hypertension in the rat: role of kidney and gonads.
1. Adrenocorticotrophin (ACTH) administration produces an adrenally dependent rise in blood pressure in rats. 2. The haemodynamic and metabolic effects of ACTH were examined in nephrectomized, 5/6 nephrectomized and orchidectomized male Sprague-Dawley rats and sham operated controls. 3. Reduction in renal mass did not increase the blood pressure rise produced by ACTH. 4. Gonadectomy did not reduce the blood pressure rise produced by ACTH, which was slightly higher in castrated animals.
Whitworth
J A
JA
Department of Nephrology, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Hewitson
T D
TD
D000324:Adrenocorticotropic Hormone; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy; D009919:Orchiectomy; D051381:Rats; D011919:Rats, Inbred Strains
D000324:Adrenocorticotropic Hormone