Pancreatic secretory trypsin inhibitor (PSTI) isolated from pig intestine. Influence on insulin and somatostatin release.
Upon investigation of pig intestinal peptides for effects on the release of endocrine hormones from the isolated perfused rat pancreas, we reported earlier that glucose-stimulated insulin release was inhibited by PEC-60, a peptide with marked sequence similarity to PSTI (pancreatic secretory trypsin inhibitor). Continuing this study we found a polypeptide, which inhibited glucose-induced insulin release but enhanced glucose-induced somatostatin secretion. Determination of the amino acid sequence of this polypeptide revealed that it is identical to that of PSTI. Thus, PSTI modulates islet hormone release.
Agerberth
B
B
Department of Biochemistry II, Karolinska Institutet, Stockholm, Sweden.
Ostenson
C G
CG
Efendic
S
S
Jörnvall
H
H
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007422:Intestines / Q000502:physiology*; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000378:metabolism*; D013552:Swine; D014359:Trypsin Inhibitor, Kazal Pancreatic / Q000302:isolation & purification / Q000494:pharmacology*
D000596:Amino Acids; D007328:Insulin; D014359:Trypsin Inhibitor, Kazal Pancreatic; D013004:Somatostatin; D005947:Glucose