[Pathogenesis of human cancer].
The multistep aspects of carcinogenesis including initiation and promotion problems in both human and experimental hepatocarcinogenesis are discussed, especially in terms of oncogene and antioncogene changes. It is shown that the H-ras activation may be an event occurring in relatively late phase of carcinogenesis in the mouse systems, and that hepatitis B integration frequently causes host chromosomal rearrangement possibly leading to inactivation of cancer suppressor genes. In addition, significance of endogenously-produced nitrosamines in hepatocarcinogenesis is pointed out.
Kitagawa
T
T
Department of Pathology, Cancer Institute, Tokyo, Japan.
D000818:Animals; D002273:Carcinogens; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D016147:Genes, Tumor Suppressor; D011905:Genes, ras; D006509:Hepatitis B; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D012307:Risk Factors; D013539:Simian virus 40 / Q000235:genetics; D014162:Transfection
D002273:Carcinogens