[The kinetic properties of inhibitory postsynaptic currents in a cell culture of chick embryo spinal cord].
Spontaneous glycine-mediated synaptic currents in culture of the spinal cord cells of chicks were analyzed by fitting exponential function to their decay. Some PSCs were of small amplitude. Their decay was single-exponential. Time constant of the decay increased with depolarization and decreased with a rise of temperature. The decay of the giant PSCs was double-exponential and had a weak potential dependence. Only slow component of the decay was sensitive to changes of the temperature. Time constant of the slow component increased in the presence of strychnine. The removal of the agonist from receptors was considered as an explanation for the variability and double-exponential character of the decays.
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D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000502:physiology; D002642:Chick Embryo; D005998:Glycine / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013331:Strychnine / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D013696:Temperature; D013997:Time Factors
D017981:Receptors, Neurotransmitter; D013331:Strychnine; D005998:Glycine
Kineticheskie svoĭstva tormoziashchikh postsinapticheskikh tokov v kul'ture kletok spinnogo mozga kurinogo émbriona.