Acute effects of anti-inflammatory drugs on neodymium:yttrium aluminum garnet laser-induced uveitis in dogs.
Dogs were treated with flunixin meglumine, a cyclooxygenase inhibitor; L-651,896, a 5-lipoxygenase inhibitor; and matrine, a herbal anti-inflammatory drug. Acute inflammation was induced in the eyes by disruption of the anterior lens capsule, using a neodymium:yttrium aluminum garnet laser. Intraocular pressure, pupil diameter, and eicosanoid production in the aqueous humor were measured. Statistically significant effects were seen in the eyes of flunixin meglumine-treated dogs where mydriasis was maintained and aqueous prostaglandin E2 concentration was reduced.
Millichamp
N J
NJ
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Dziezyc
J
J
Rohde
B H
BH
Chiou
G C
GC
Smith
W B
WB
D000470:Alkaloids / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000737:chemistry; D001572:Benzofurans / Q000494:pharmacology / Q000627:therapeutic use; D003002:Clonixin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D015232:Dinoprostone / Q000032:analysis; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D007429:Intraocular Pressure / Q000187:drug effects; D053685:Laser Therapy / Q000009:adverse effects / Q000662:veterinary*; D007975:Leukotriene B4 / Q000032:analysis; D016859:Lipoxygenase Inhibitors; D011680:Pupil / Q000187:drug effects; D011807:Quinolizines; D014605:Uveitis / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D000093842:Matrines
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001572:Benzofurans; D016859:Lipoxygenase Inhibitors; D011807:Quinolizines; D007975:Leukotriene B4; C014558:flunixin meglumine; C053727:L 651896; D015232:Dinoprostone; D003002:Clonixin; D000093842:Matrines