Effect of two flavonoid compounds on central nervous system. Analgesic activity.
The psychopharmacological profile of quercetin (Q) and penta-O-ethylquercetin (PQ) showed for both compounds a sedative effect on central nervous system in mice. In this set of pharmacological tests (hypothermia, spontaneous motility, psychomotor activity) penta-O-ethylquercetin always exerted a more pronounced effect than quercetin, probably due to the difference of lipophilicity. In analgesia experiments such as acetic acid-induced writhings, penta-O-ethylquercetin showed a significant dose-related effect whereas quercetin was inactive. As pretreatment with naloxone failed to antagonize the analgesic activity of penta-O-ethylquercetin, it was suggested that penta-O-ethylquercetin acted mainly peripherally.
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Laboratoire de Chimie Biologique, Institut National des Sciences Appliquées de Lyon, Unité INSERM 205, Villeurbanne, France.
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Prigent
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D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000700:Analgesics; D006993:Hypnotics and Sedatives; D016718:Arachidonic Acid; C057450:penta-O-ethylquercetin; D011794:Quercetin; D015105:3',5'-Cyclic-AMP Phosphodiesterases