title: Influence of chronic lithium treatment on urinary amount of furosemide in rats.
abstract: The present study was undertaken to examine whether the urinary amount of furosemide is influenced by chronic lithium treatment. LiCl at 2 mEq/kg/day in 1 ml vehicle (5% glucose solution) or 1 ml of vehicle alone was injected intraperitoneally for 8 days into Wistar rats. On day 8, 30 mg/kg of furosemide in 3% body weight of 1% NaCl was given orally, and urine was collected for 6 hr after dosage. The urinary amount of furosemide in the Li-treated rats was significantly lower than that in the control animals [Li group (n = 12): 514 +/- 75 (mean +/- S.E.) vs. control group (n = 12): 916 +/- 85 micrograms/kg/6 hr, P less than 0.01]. This finding indicates that pharmacokinetic alterations of furosemide might occur during chronic treatment with lithium.
authors.affiliation: Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Fujimura
authors.forename: K
authors.initials: K
authors.lastname: Ohashi
authors.forename: A
authors.initials: A
authors.lastname: Ebihara
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology*; D004326:Drinking; D005665:Furosemide / Q000008:administration & dosage / Q000652:urine*; D008094:Lithium / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D018021:Lithium Chloride; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D014556:Urine
chemical_list: D002712:Chlorides; D005665:Furosemide; D008094:Lithium; D012083:Renin; D018021:Lithium Chloride