Adamantinoma of the tibia with pulmonary metastases and hypercalcemia.
Adamantinomas of long bones are rare primary malignant bone tumors. A case of a woman who died of pulmonary metastases of an adamantinoma of the tibia is presented. A unique feature of this case is the association with hypercalcemia. The association of hypercalcemia, hypophosphatemia, decreased parathyroid hormone levels and increased urinary cAMP excretion suggests a humorally mediated hypercalcemia. Histologic and ultrastructural analysis of the pulmonary metastases demonstrated that the tumor was composed of a heterogeneous cell population with mesenchymal and epithelial differentiation.
Van Schoor
J X
JX
Department of Respiratory Diseases, University Hospital, Ghent, Belgium.
Vallaeys
J H
JH
Joos
G F
GF
Roels
H J
HJ
Pauwels
R A
RA
Van Der Straeten
M E
ME
D000328:Adult; D001859:Bone Neoplasms / Q000150:complications / Q000473:pathology*; D000242:Cyclic AMP / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D010710:Phosphates / Q000097:blood; D011859:Radiography
D010710:Phosphates; D000242:Cyclic AMP