Catecholamine-induced cardiomyopathy in multiple endocrine neoplasia. A histologic, ultrastructural, and biochemical study.
A catecholamine-induced dilated cardiomyopathy is reported in a patient with multiple endocrine neoplasia, type 3. A histologic and ultrastructural study has been undertaken in cardiac biopsy samples, together with determination of myocardial Ca++ and cellular membrane fatty acids. Contraction band necrosis of cardiocytes with supercontraction of sarcomeres progressing to myofibrolysis and increased levels of myocardial Ca++ have been found as morphologic and biochemical abnormalities, respectively. No lipoperoxidation of cellular membranes or an alpha-adrenergic mediated reduction of coronary supply could be recognized in the study. We indicate a receptor-mediated intracellular Ca++ overload as the main abnormality responsible for myocardial impairment.
Frustaci
A
A
Institute of Cardiology and Internal Medicine, Catholic University, Rome, Italy.
Loperfido
F
F
Gentiloni
N
N
Caldarulo
M
M
Morgante
E
E
Russo
M A
MA
D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000378:metabolism; D000328:Adult; D002118:Calcium / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002395:Catecholamines / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008297:Male; D009377:Multiple Endocrine Neoplasia / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D010673:Pheochromocytoma / Q000150:complications* / Q000378:metabolism; D012518:Sarcomeres / Q000648:ultrastructure; D013964:Thyroid Neoplasms / Q000150:complications
D002395:Catecholamines; D005227:Fatty Acids; D002118:Calcium