A comparison of renal damage induced by varying modes of shock wave generation.
To evaluate for the possible differences in the extent of pathologic injury occurring following treatment with various lithotripsy modalities, we subjected rabbits to treatment on either an electrohydraulic, electromechanical, or piezoelectric lithotripter. Functional evaluations by enzymuria failed to reveal any difference in the extent of damage between the lithotripters. Pathologic evaluation of the kidneys revealed that both electrohydraulic and electromechanical lithotripsy resulted in an increased instance of acute subcapsular hematoma and fibrosis when compared to piezoelectric treated kidneys (p less than 0.001). Despite the definitive differences noted in the acute animals, there was no significant variation in the area of permanent renal damage that occurred between the various lithotripters.
Morris
J S
JS
Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235.
Husmann
D A
DA
Wilson
W T
WT
Denstedt
J
J
Fulgham
P F
PF
Clayman
R V
RV
Preminger
G M
GM
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D005260:Female; D007668:Kidney / Q000201:enzymology / Q000293:injuries* / Q000473:pathology; D008096:Lithotripsy / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods; D011817:Rabbits; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D005723:gamma-Glutamyltransferase; D000118:Acetylglucosaminidase