Ubiquitin-mediated processes in erythroid cell maturation.
Response of the ATP, ubiquitin-dependent system during the enhanced degradation of erythrocyte maturation conforms to the general regulatory features common to several similar but unrelated systems. In erythroid cells enhanced degradation follows three phases: (1) Onset of degradation characterized by an increase in the intracellular concentration of free and conjugated ubiquitin, brought about by reduction in mean cell volume; (2) Active enhanced degradation during cellular remodeling; and (3) Loss of activity as a consequence of spontaneous inactivation of components required for ubiquitin conjugation. The extent of degradative remodeling is probably functionally limited by the loss of these critical ligation enzymes.
Haas
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Department of Biochemistry, Medical College of Wisconsin, Milwaukee.
D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D016923:Cell Death; D002454:Cell Differentiation; D010450:Endopeptidases / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism; D004920:Erythropoiesis; D008954:Models, Biological; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D014452:Ubiquitins / Q000502:physiology*
D001798:Blood Proteins; D011506:Proteins; D014452:Ubiquitins; D000255:Adenosine Triphosphate; D010450:Endopeptidases