[Results of the evaluation of platelet sodium-proton exchange in the young hypertensive subject].
In order to assess the relationships between increased cellular sodium-proton (Na+/H+) exchange and cardiovascular abnormalities in essential hypertension (EH), 21 young subjects as part of an ongoing longitudinal study were tested for the platelets Na+/H+ exchange using the amiloride sensitive sodium dependent component of platelet volume change under cytoplasmic acidification induced by a sodium propionate medium; cell volumes were determined by electronic cell sizing (Livne et al., Lancet 1987; i: 533-6). 24 normal subjects with normotension and without familial history of hypertension were taken as controls. Data of ambulatory blood pressure recording (ABPR) defined 2 groups according to the presence of normotension (group I, n = 10), or of hypertension (group II, n = 11): established (n = 2) or borderline (n = 9) hypertension. Hypertensive subjects (group II) had increased values of Na+/H+ exchange (k coefficient, mean (SEM): 0.287 (0.07) vs 0.228 (0.05) in control group (p less than 0.01). Na+/H+ rates were significantly related to ABPR data (r = 0.46, p less than 0.02 with diastolic charge during ABPR), but not to left ventricular mass index in g/m2 by echocardiography. Increased rates of platelets Na+/H+ exchange which were related to diastolic blood pressure levels by ABPR, and perhaps to the level of peripheric vascular resistances, may play a significant role in the development of EH in the early stages.
Salles
J P
JP
Unité INSERM 326, Toulouse.
Barthe
P
P
Bouissou
F
F
Chamontin
B
B
Bégasse
F
F
Chap
H
H
D000293:Adolescent; D000328:Adult; D001693:Biological Transport, Active; D001792:Blood Platelets / Q000378:metabolism*; D015924:Blood Pressure Monitors; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007474:Ion Exchange; D011522:Protons; D012964:Sodium / Q000097:blood* / Q000378:metabolism
D011522:Protons; D012964:Sodium
Résultats de l'évaluation de l'antiport sodium-proton plaquettaire chez le sujet jeune hypertendu.