title: Plasma interleukin-1, tumour necrosis factor and hypothalamic-pituitary-adrenal axis responses during migraine attacks.
abstract: To evaluate systemic cytokine and hypothalamic-pituitary-adrenal axis responses in migraine, we measured plasma levels of tumour necrosis factor, interleukin-1, adrenocorticotropic hormone, and cortisol, as well as body temperature during and between attacks in 20 migraine patients. We found no evidence of systemic rise of cytokines during migraine attacks. Plasma cortisol and adrenocorticotropic hormone responses were similar to those found to experimentally-induced pain in normal subjects, i.e. elevated cortisol and unchanged adrenocorticotropic hormone levels. Unexpectedly, body temperature tended to be lower during attacks.
authors.affiliation: Department of Neurology, University Hospital, Leiden, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: van Hilten
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: J W
authors.initials: JW
authors.lastname: Van der Meer
authors.forename: H J
authors.initials: HJ
authors.lastname: Gijsman
authors.forename: B J
authors.initials: BJ
authors.lastname: Looij
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000503:physiopathology*; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone