Oxygen-induced modifications of benzodiazepine receptors and D2 dopamine receptors in the rat under hyperoxia.
Peripheral-type benzodiazepine Receptors (PBR) in the kidney and Central-type Benzodiazepine Receptors (CBR) in the cerebral cortex were not affected in rats exposed to chronic hyperoxia (85% O2, ATA, 6 days). Nevertheless, cortical CBR showed a significant decrease (29%) after hyperbaric hyperoxia (100% O2, 3.5 ATA, 2 h) in rats at a preconvulsive stage, with no concomitant alteration of kidney PBR. A similar down-regulation of striatal D2 dopamine receptors was noticed (27%)--after hyperbaric hyperoxia--without any modification of cortical PBR. On the contrary, an up regulation of liver PBR was obtained in the same conditions (20%). It is likely that receptors implicated in neurotransmission are particularly down regulated or altered under hyperbaric hyperoxia.
Courtiere
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A
Centre d'Etudes et de Recherches Biophysiologiques Appliquées à la Marine, Division de Biochimie, Toulon Naval, France.
Reybaud
J
J
Camilla
C
C
Lobert
P
P
Drouet
J
J
Jadot
G
G
D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D015536:Down-Regulation; D005445:Flunitrazepam / Q000378:metabolism; D006931:Hyperbaric Oxygenation / Q000379:methods; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects*; D013134:Spiperone / Q000378:metabolism
D001570:Benzodiazepinones; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam; D013134:Spiperone; D005445:Flunitrazepam; D010100:Oxygen