Accessory cell-derived costimulatory signals regulate T cell proliferation.
The costimulatory effects of anti-CD28 antibody or accessory cells on T cells were shown to be very similar. Both stimuli: (a) allowed T cell proliferation and IL-2 production in response to immobilized anti-CD3 antibody or antigen presented by APC whose costimulatory capacity had been damaged by fixation; and (b) stimulated cyclosporin A-resistant T cell proliferation in the presence of a phorbol ester. These similarities raise the possibility that anti-CD28 antibody binding to T cells delivers a costimulatory signal that is normally delivered by the interaction of CD28 with a complementary ligand on APC.
Urdahl
K B
KB
Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455.
Jenkins
M K
MK
Norton
S D
SD
D000328:Adult; D000938:Antigen-Presenting Cells / Q000502:physiology*; D015703:Antigens, CD / Q000502:physiology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D018106:CD28 Antigens; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D007376:Interleukin-2; D013755:Tetradecanoylphorbol Acetate