title: [Is fluidization of the phospholipid bilayer by general anesthetics a reason for general anesthesia?].
abstract: It was found that chlorpromazine and pipolfene potentiating general anaesthesia increase viscosity of phospholipid membrane in the region of polar headgroups and in the hydrophobic area near glycerol sceleton. These results (independently of potentiating mechanism) confuse a mechanism of anaesthetics action as increased fluidity of membrane phospholipids.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Burt
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Abramov
authors.forename: V I
authors.initials: VI
authors.lastname: Sachkov
mesh_terms: D000768:Anesthesia, General; D000777:Anesthetics / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D008051:Lipid Bilayers; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids; D010743:Phospholipids; D011398:Promethazine / Q000494:pharmacology
chemical_list: D000777:Anesthetics; D008051:Lipid Bilayers; D008563:Membrane Lipids; D010743:Phospholipids; D011398:Promethazine; D002746:Chlorpromazine
vernacular_title: Iavliaetsia li indutsirovannoe obshchimi anestetikami razzhizhenie fosfolipidnogo bisloia prichinoĭ obshcheĭ anestezii?