title: Animal experiments for the evaluation of laserspectroscopy in the fetus during labor.
abstract: Laserspectroscopy with near-infrared light is newly available for clinical application. The equipment consists of a near-infrared data collection unit (NIRDCU) and a personal computer. Emission of laser light at wavelengths of 775, 805, 845 and 904 nm is provided by the four laser diodes of the NIRDCU. By analyzing changes of optical density during laser radiation, information is obtained regarding the intracellular redox state and relative changes of blood volume. During measurement with the system on the fetal scalp during delivery we were able to get a first impression of the method's potential. While the application of the laser sensors is still cumbersome, signals providing information of the relative changes of hemoglobin concentration, relative changes of blood volume and cytochrome aa3 seems achievable. Laserspectrophotometric monitors may become safe, low cost and portable instruments for the non-invasive assessment of the biochemical and biophysical status in the fetus.
authors.affiliation: Department of Gynecology and Obstetrics, University of Bonn, Fed. Rep. Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Gorissen
authors.forename: H
authors.initials: H
authors.lastname: Eilers
authors.forename: H
authors.initials: H
authors.lastname: Fahnenstich
authors.forename: A
authors.initials: A
authors.lastname: Dorer
authors.forename: D
authors.initials: D
authors.lastname: Krebs
mesh_terms: D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism; D005069:Evaluation Studies as Topic; D005260:Female; D005323:Fetal Monitoring / Q000379:methods*; D005333:Fetus / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism; D007743:Labor, Obstetric / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011247:Pregnancy; D012756:Sheep; D013057:Spectrum Analysis / Q000379:methods*
chemical_list: D006454:Hemoglobins; D003576:Electron Transport Complex IV; D010100:Oxygen