title: External control of drug release and penetration: enhancement of the transdermal absorption of indomethacin by ultrasound irradiation.
abstract: The effect of ultrasound (1 MHz) on transdermal absorption of indomethacin from an ointment has been studied in rats. Ultrasound energy was supplied for 10 min at a range of intensities (0.25, 0.5 and 0.75 W cm-2), energy levels commonly used for therapeutic purposes. The pronounced effect of ultrasound on transdermal absorption of indomethacin was observed for all three intensities studied. The mean AUC value (33.22 micrograms h mL-1) after irradiation at 0.75 W cm-2 was 3.4 times the control value (9.70 micrograms h mL-1).
authors.affiliation: Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Mizuoka
authors.forename: M
authors.initials: M
authors.lastname: Oda
authors.forename: M
authors.initials: M
authors.lastname: Takada
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D009824:Ointments; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption; D014465:Ultrasonics
chemical_list: D009824:Ointments; D007213:Indomethacin