Antidepressants affect amine modulation of neurotransmission in the rat hippocampal slice--I. Delayed effects.
The effects of long-term treatment with the antidepressant drugs, desipramine (DMI) and mianserin (MIA) on neurotransmission in the hippocampal slice were studied by examining the actions of serotonin (5-HT), isoprenaline and (+/-)-baclofen on the population spike in the pyramidal cell layer, recorded in area CA1. The decrease in amplitude of the population spike by 5-HT (1-10 microM) was facilitated by long-term treatment with DMI but not significantly with MIA. Both DMI and MIA depressed the excitatory action of isoprenaline (0.3 microM), whereas the inhibitory responses to (+/-)-baclofen (0.3-3 microM) were unaffected. The results show that significant changes in serotonergic and beta-adrenergic neurotransmission can be demonstrated ex vivo after in vivo treatment with antidepressants and that these changes partly substantiate data measured in vivo.
Dijcks
F A
FA
Organon International, CNS Pharmacology Department, Oss, The Netherlands.
Ruigt
G S
GS
de Graaf
J S
JS
D000222:Adaptation, Physiological / Q000187:drug effects*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D001679:Biogenic Amines / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology*; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*; D013997:Time Factors
D001679:Biogenic Amines; D008803:Mianserin; D012701:Serotonin; D001418:Baclofen; D007545:Isoproterenol; D003891:Desipramine