title: Increase in serum myoglobin, creatine kinase, and free fatty acids, during recovery from a paralytic attack in hypokalemic periodic paralysis.
abstract: In a patient with hypokalemic periodic paralysis (HPP), recovery from a paralytic attack, coinciding with the restoration of plasma potassium, was associated with a rise in serum myoglobin (Mb) and creatine kinase (CK). The increase of muscle proteins in serum was preceded by an increase in serum free fatty acids (FFA). An increased permeability of the sarcolemma, caused by an accumulation of FFA within the muscle cell, might underly the reflux of potassium into the circulation. This might represent a mechanism by which the paralytic attacks in HPP terminate.
authors.affiliation: Department of Neurology, Academisch Ziekenhuis Vrije Universiteit Brussel, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: De Keyser
authors.forename: H
authors.initials: H
authors.lastname: Slabbynck
authors.forename: M
authors.initials: M
authors.lastname: Laureys
authors.forename: J
authors.initials: J
authors.lastname: Smitz
authors.forename: M
authors.initials: M
authors.lastname: Vervaeck
authors.forename: G
authors.initials: G
authors.lastname: Ebinger
mesh_terms: D000293:Adolescent; D003402:Creatine Kinase / Q000097:blood*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D007008:Hypokalemia / Q000097:blood* / Q000503:physiopathology; D008297:Male; D009211:Myoglobin / Q000097:blood*; D010243:Paralysis / Q000097:blood* / Q000503:physiopathology; D011188:Potassium / Q000097:blood; D013997:Time Factors
chemical_list: D005230:Fatty Acids, Nonesterified; D009211:Myoglobin; D003402:Creatine Kinase; D011188:Potassium