[Clinical and immunological features of allergic bronchopulmonary aspergillosis].
28 cases of allergic bronchopulmonary mycosis (ABPM) were diagnosed by criteria formulated in 1977 by Rosenberg and by referring to the results of serum IgE-Af and IgG-Af detection. The common clinical features were wheezing, fever, bloody sputum, sputum plugs, chest pain and loss of energy. On chest X-ray, infiltrates were found in 28 cases, fibrosis in 12, atelectasis in 4, lobar shrinkage in 1, and aspergilloma in 1, Chest films in 14 cases showed shadows suggesting in the presence of CB. Tomography (linear and/or axial) showed CB in 9 cases. All the cases had positive immediate reactions in skin test to moulds. Serum precipitating antibody against moulds were demonstrated in 27 cases. A cross reactivity exists among moulds either in skin test or in gel double diffusion technique. The sensitizing mould was chiefly Aspergillus species, especially Af. Serum IgE-Af and IgG-Af were measured in 14 cases caused by Af. The mean OD value was over 2 times greater than that in the patients with asthma who had positive skin test to Af. Corticosteroids were used for treatment, and the results of followup of 23 cases suggested that such long term complications as CB, fibrosis and refractory bacterial infection were the chief causes of poor prognosis.
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D000328:Adult; D000908:Antibodies, Fungal / Q000097:blood; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000175:diagnosis / Q000276:immunology*; D001232:Aspergillus fumigatus / Q000276:immunology; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged
D000908:Antibodies, Fungal