Distribution of the 1,25 dihydroxy-vitamin D3 receptor in the bursa of Fabricius of chicken.
The vitamin D3 metabolite 1,25(OH)2D3 is probably involved in B lymphocyte ontogeny. We therefore determined the distribution of the 1,25(OH)2D3 receptor in the bursa of Fabricius and spleen cells of 7-day-old chicks, by immunohistochemistry using a monoclonal antibody against the chick intestinal cell 1,25(OH)2D3 receptor. The bursa cells of young (7-day-old) chicks contained large amounts of receptor while the spleen cells did not. The bursa cells of older (35-day-old) chicks contained fewer receptors, but the number of receptors in the spleen increased.
Petrini
M
M
Chair of Histology and Embryology, Faculty of Medicine, University of Pisa, Italy.
Bianchi
F
F
Dolfi
A
A
Lupetti
M
M
D000375:Aging / Q000378:metabolism; D000818:Animals; D002060:Bursa of Fabricius / Q000254:growth & development / Q000378:metabolism*; D002645:Chickens; D007124:Immunoenzyme Techniques; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000378:metabolism*; D013154:Spleen / Q000254:growth & development / Q000378:metabolism
D018167:Receptors, Calcitriol; D011987:Receptors, Steroid