[Autoantibodies to glycolipid antigens of oligodendroglia in acute and chronic disorders of spinal circulation].
Measurements were made of the titers of autoantibodies to antigenic markers of oligodendrocytes and myelin galactocerebrosides in the blood serum and cerebrospinal fluid from 29 patients with ischemic cerebrospinal insult and 100 patients with ischemic myelopathy. Acute and chronic disorders of spinal circulation were found to be associated with production of auto-antibodies to galactocerebrosides. The interrelationship was discovered between the fact of auto-antibody production and the degree of the recovery of deranged function (in poor recovery, auto-antibodies were preserved in the blood serum up to 3 years in diagnostically significant titers). A correlation was demonstrated between the rate of ischemic myelopathy progress and the fact of demonstration of autoantibodies to galactocerebrosides in the blood serum. The data obtained can be used in judging the character of the disease and planning the rehabilitation measures.
Makarov
A Iu
AIu
Taranova
N P
NP
Leĭkin
I B
IB
Luchakova
O S
OS
Loboda
E B
EB
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis* / Q000276:immunology; D002908:Chronic Disease; D006017:Glycolipids / Q000276:immunology*; D006801:Humans; D007511:Ischemia / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D009836:Oligodendroglia / Q000276:immunology*; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology
D000941:Antigens; D001323:Autoantibodies; D006017:Glycolipids
Autoantitela k glikolipidnym antitelam oligodendroglii pri ostrykh i khronicheskikh narusheniiakh spinal'nogo krovoobrashcheniia.