[A case-control study on HBV infection in families of hepatocellular carcinoma-application of conditional logistic regression model].
To assess the risk of HBV infection in families of hepatocellular carcinoma (HCC), methods of case-control study and conditional logistic regression model were applied. The total infection rate of HBV was 88.89% in cases and 55.56% in controls, showing a statistically significant difference (P less than 0.01). Analysis of logistic model showed that the variable interaction of HBsAg and anti-HBc in pointer group and the variable five-HBV-marker in siblings group were the most important risk factors in these families. However, no significant difference was found in each marker of HBV between two spouse-groups (P greater than 0.05). This study indicates a familial clustering of HBV infection in HCC families.
Chen
J
J
Department of Epidemiology, Qidong Liver Cancer Institute, Jiangsu.
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000453:epidemiology; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005192:Family Health; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology / Q000635:transmission*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens