Mitochondrial import receptors for precursor proteins.
The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42) and p32 which have a role in initial steps of protein import. The first three components are present in a multi-subunit complex that catalyses recognition and membrane insertion of precursor proteins.
Pfanner
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Institut für Physiologische Chemie, Universität München, FRG.
Söllner
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Neupert
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D001693:Biological Transport, Active; D005656:Fungal Proteins; D008565:Membrane Proteins; D008928:Mitochondria / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear
D005656:Fungal Proteins; C066557:MOM19 protein, Neurospora crassa; D008565:Membrane Proteins; D011498:Protein Precursors; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear