Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man.
A system of three non-linear differential equations with exponential feedback terms is proposed to model the self-regulating cortisol secretion system and explain the fluctuation patterns observed in clinical data. It is shown that the model exhibits bifurcation and chaos patterns for a certain range of parametric values. This helps us to explain clinical observations and characterize different dynamic behaviors of the self-regulative system.
Lenbury
Y
Y
Department of Mathematics, Faculty of Science, Mahidol University, Bangkok, Thailand.
Pacheenburawana
P
P
D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D008954:Models, Biological; D010913:Pituitary-Adrenal System / Q000378:metabolism*
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone