Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents.
In order to study the structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential anti-retroviral agents, various purine derivatives have been synthesized and tested against rous sarcoma virus (RSV) in chick embryo fibroblast (CEF) cells, and against human immunodeficiency virus (HIV) in human CD4+ T cells (ATH8). Some of the new purine derivatives found to be significant antiretroviral activities. And the correlations of activity between anti-RSV and anti-HIV have shown fairly good values so far.
Kojima
E
E
Research Laboratory of Bioresources, Sanyo-Kokusaku Pulp Co. Ltd, Iwakuni, Japan.
Shirasaka
T
T
Machida
M
M
Yoshioka
H
H
Murakami
K
K
Mitsuya
H
H
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001358:Avian Sarcoma Viruses / Q000187:drug effects*; D002460:Cell Line; D002642:Chick Embryo; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D006678:HIV / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D015224:Dideoxynucleosides