Recent advances of PET in temporal lobe epilepsy.
Recent advancement of PET studies in patients with temporal lobe epilepsy was reviewed. Changes of receptor plasticity are also examined in the experimental model of temporal lobe epilepsy in rats with unilateral injection of Kainic acid into the basolateral portion of the amygdala. The characteristic changes of receptor function in the specific topographical areas in both hippocampi with and without any morphological changes in these rats were observed. We plan to investigate these changes of receptor plasticity by PET with 11C-labeled ligands in patients with temporal lobe epilepsy in the near future to obtain a better understanding of the mechanisms of temporal lobe epilepsy.
Yamamoto
Y L
YL
Montreal Neurological Institute, McGill University, Canada.
D000679:Amygdala / Q000503:physiopathology; D000818:Animals; D001931:Brain Mapping; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005071:Evoked Potentials / Q000502:physiology; D005911:Gliosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D011963:Receptors, GABA-A; D017981:Receptors, Neurotransmitter; D011493:Protein Kinase C