title: [The reproduction of the hepatitis A virus in cell cultures].
abstract: A comparative analysis of reproduction of 9 strains of hepatitis A viruses (HSA-15, CF-979, MI, MBB 11/5, H-141, KMW-1, GBM, IH-26, WR-61) from different regions of the world in cell cultures (PLC/PRF/5, HEL-240, FRhK-4, MK) revealed the differences in the capacity of the viruses for reproduction in these cell lines. The factors influencing HAV reproduction in cell cultures such as temperature, medium, and sera were studied. In one-cycle infection, accumulation of vRNA and formation of virus particles were analysed.
authors.forename: V R
authors.initials: VR
authors.lastname: Farashian
authors.forename: A B
authors.initials: AB
authors.lastname: Bychenko
authors.forename: E K
authors.initials: EK
authors.lastname: Artemov
authors.forename: I A
authors.initials: IA
authors.lastname: Kuzaeva
mesh_terms: D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured / Q000382:microbiology; D003470:Culture Media; D006507:Hepatovirus / Q000032:analysis / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D012367:RNA, Viral / Q000032:analysis; D013696:Temperature; D014771:Virion / Q000502:physiology; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication / Q000502:physiology*
chemical_list: D003470:Culture Media; D012367:RNA, Viral
vernacular_title: Reproduktsiia virusa gepatita A v kletochnykh kul'turakh.