Beta-blockade during whole-body hyperthermia: a toxicity study in the dog.
A radiant heat device (RHD) for whole-body hyperthermia (WBH) has been safely and effectively used with a dog model. The cardiovascular changes which occur in the dog during WBH--including heart rate, blood pressure, cardiac output, stroke volume and ejection fraction--agree qualitatively and quantitatively with changes observed in previous WBH-RHD studies done in pigs and humans. We elected to study the effect of propanolol in dogs during WBH in order to evaluate this drug's potential use in human cancer patients who are ineligible for WBH because of coronary artery disease. This report details cardiovascular changes which occur with beta-blockade during 42 degrees C WBH in the dog. Our results show that the level of beta-blockade needed to control heart rate during WBH produces acute cardiovascular decompensation.
Robins
H
H
Department of Human Oncology, School of Veterinary Medicine, University of Wisconsin Clinical Cancer Center, Madison 53792.
Hugander
A
A
Besozzi
M
M
Schmitt
C L
CL
Martin
P A
PA
Zager
L V
LV
Grossman
J
J
D000818:Animals; D002303:Cardiac Output, Low / Q000139:chemically induced; D002319:Cardiovascular System / Q000187:drug effects* / Q000503:physiopathology; D000075202:Contraindications; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D011433:Propranolol / Q000633:toxicity*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D011433:Propranolol