title: A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
abstract: There are at least 3 isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, a bifunctional enzyme which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate. A 22-kb rat gene that encodes the heart isozyme has been identified and compared with the 55-kb rat gene encoding the liver and muscle isozymes which had been described earlier. Although these 2 genes include 12 successive similar exons, they contain dissimilar exons at both ends, consistent with the occurrence of different regulatory domains at the N- and C-termini in the 3 isozymes.
authors.affiliation: Hormone and Metabolic Research Unit, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.
authors.forename: M I
authors.initials: MI
authors.lastname: Darville
authors.forename: M
authors.initials: M
authors.lastname: Chikri
authors.forename: E
authors.initials: E
authors.lastname: Lebeau
authors.forename: L
authors.initials: L
authors.lastname: Hue
authors.forename: G G
authors.initials: GG
authors.lastname: Rousseau
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D005091:Exons / Q000235:genetics; D005635:Fructosediphosphates / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology; D007527:Isoenzymes / Q000235:genetics; D008099:Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D025481:Phosphofructokinase-2; D010744:Phosphoric Monoester Hydrolases / Q000235:genetics*; D010770:Phosphotransferases / Q000235:genetics*; D051381:Rats; D012689:Sequence Homology, Nucleic Acid
chemical_list: D005635:Fructosediphosphates; D007527:Isoenzymes; C027652:fructose 2,6-diphosphate; D010770:Phosphotransferases; D025481:Phosphofructokinase-2; D010744:Phosphoric Monoester Hydrolases