Human peripheral nerve sheath neoplasm: expression of Schwann cell-related markers and their relation to malignant transformation.
We immunohistochemically examined the expression of Schwann cell-related markers, nerve growth factor (NGF) receptor, S-100 alpha- and beta-proteins, glial fibrillary acidic protein (GFAP), and galactocerebroside (gal C) in 5 malignant schwannomas, 21 benign peripheral nerve sheath tumors, and 4 apparently normal sural nerves. NGF receptor was expressed in the malignant schwannomas and benign peripheral nerve sheath tumors, but not in the endoneurium of apparently normal peripheral nerves. S-100 alpha-protein was observed in malignant schwannomas and in some neurofibroma cells. All cases were strongly positive for S-100 beta-protein but were negative for GFAP and gal C. Our results suggest that these Schwann cell-related markers may be useful in identifying peripheral nerve sheath neoplasma as well as their malignant transformation.
Yasuda
T
T
Fourth Department of Internal Medicine, Aichi Medical University, Nagakute, Japan.
Sobue
G
G
Ito
T
T
Doyu
M
M
Sugiura
I
I
Hashizume
Y
Y
Kato
K
K
D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000737:chemistry; D005260:Female; D005699:Galactosylceramides / Q000032:analysis; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis; D009442:Neurilemmoma / Q000737:chemistry*; D009455:Neurofibroma / Q000737:chemistry*; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000032:analysis; D017475:Receptors, Nerve Growth Factor; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells / Q000737:chemistry*
D005699:Galactosylceramides; D005904:Glial Fibrillary Acidic Protein; D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; D009418:S100 Proteins; C002454:galactocerebroside