[Anti-idiotypic antibodies against antibodies to the herpes simplex virus and its early antigens].
Polyclonal anti-idiotypic antibodies (anti-Id-AT or AT2) were produced to AT idiotopes of virion antigens--structural proteins of herpes simplex virus (HSV) and of early virus-induced antigens (VIA). The method of SPRIA established that anti-Id-AT seemed to be associated with AT active centers. Besides, immunization with anti-Id-AT produced anti-anti-Id-AT (AT3) similar in their specificity with antiviral AT or anti-VIA. It was shown that AT2 could be used as a diagnostic preparation instead of specific antigen for the detection of antibody to HSV or VIA in human sera by indirect RIA.
Kosiakova
N P
NP
Pavliuchenkova
R P
RP
Posevaia
T A
TA
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology* / Q000302:isolation & purification; D007106:Immune Sera / Q000302:isolation & purification; D007114:Immunization / Q000379:methods; D051379:Mice; D011817:Rabbits; D011863:Radioimmunoassay / Q000379:methods; D018139:Simplexvirus / Q000276:immunology* / Q000302:isolation & purification; D013997:Time Factors; D014776:Virus Cultivation
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D000956:Antigens, Viral; D007106:Immune Sera
Antiidiotipicheskie antitela protiv antitel k virusu prostogo gerpesa i ego rannim antigenam.