title: Tube feeding-related diarrhea in acutely Ill patients.
abstract: Acutely ill patients received tube feeding for an average of 15.8 days and, on average, 35% of those days were spent in the intensive care unit (ICU). Patients were prospectively assigned either a fiber-free formula (FFF-OSMOLITE HN, Ross; n = 50) or a fiber-supplemented (soy polysaccharide 14.4 g/L) formula (FSF = JEVITY, Ross; n = 50). Diarrhea was defined as three or more loose or watery stools per day and occurred in 30% of all patients. Diarrhea developed in 29 (41%) of the 71 patients who received antibiotics during, or within 2 weeks prior to, the feeding period, whereas only 1 (3%) of the 29 patients not receiving antibiotics developed diarrhea (p less than 0.005); and this patient developed diarrhea on the day of death. Among the 30 patients with diarrhea, stool Clostridium difficile (CD) toxin was positive in 15 (50%), negative in 11 (37%), and was not measured in four. The mean serum albumin was significantly lower in patients with diarrhea (2.43) than in those without diarrhea (2.75) (p = 0.043). There were no significant differences in age, sex, diagnoses, number of feeding days, and percent ICU days between patients with and without diarrhea. While not statistically significant, patients who received FSF were observed to have a lower incidence of diarrhea, a lower percentage of diarrhea days per total feeding days, and a lower frequency of positive CD toxin assays than patients who received FFF. In this patient population, antibiotic usage was the factor most strongly associated with diarrhea during tube feedings.
authors.affiliation: Graduate Hospital, University of Pennsylvania School of Nursing, Philadelphia.
authors.forename: P A
authors.initials: PA
authors.lastname: Guenter
authors.forename: R G
authors.initials: RG
authors.lastname: Settle
authors.forename: S
authors.initials: S
authors.lastname: Perlmutter
authors.forename: P L
authors.initials: PL
authors.lastname: Marino
authors.forename: G A
authors.initials: GA
authors.lastname: DeSimone
authors.forename: R H
authors.initials: RH
authors.lastname: Rolandelli
mesh_terms: D000208:Acute Disease / Q000628:therapy*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000032:analysis; D003967:Diarrhea / Q000209:etiology*; D004043:Dietary Fiber / Q000008:administration & dosage; D004750:Enteral Nutrition / Q000009:adverse effects*; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004043:Dietary Fiber; D012709:Serum Albumin; C031815:toxB protein, Clostridium difficile