Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3.
A gene encoding the endogenous superantigen Mlsc, which deletes Tcrb-V3+ T cells in the NOD inbred mouse strain, was found to co-segregate with Mtv-3 on chromosome 11. This identifies a fourth gene encoding a deletion ligand for Tcrb-V3+ T cells and extends recently published observations in support of the hypothesis that a number of endogenous superantigens are the products of Mtv proviruses.
Fairchild
S
S
Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, England.
Knight
A M
AM
Dyson
P J
PJ
Tomonari
K
K
D000818:Animals; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D005796:Genes; D008024:Ligands; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D051379:Mice; D016747:Minor Lymphocyte Stimulatory Antigens / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D016662:Virus Integration
D008024:Ligands; D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta