title: White blood cell scintigraphy with monoclonal antibodies in the study of the infected endoprosthesis.
abstract: Forty-three patients with suspected infection of a hip or a knee prosthesis were studied with white blood cell scintigraphy (WBC), using technetium-99m (n = 37) or iodine-123 (n = 6) labelled monoclonal mouse antibody (MoAb). Previously, all patients had undergone skeletal scintigraphy, which was performed as a three-phase study in 33 cases. The final diagnosis was established by open surgery, histology and culture in 37 cases, by puncture and culture in 3 cases, and by clinical follow-up of at least 6 months in 3 cases. Eighteen prostheses were infected, 25 uninfected. The delayed phase of skeletal scintigraphy had a sensitivity of 92%, a specificity of 24% and an accuracy of 48% in the detection of infection. The perfusion and blood pool activity of the three-phase bone scan had a sensitivity of 67%, a specificity of 71% and an accuracy of 70%. The diagnostic value of WBC was sensitivity 89%, specificity 84% and accuracy 86%. WBC with 99m-Tc-MoAb is easy to perform and always available. Its diagnostic accuracy is similar to conventional WBC scintigraphy with either indium-111 or technetium-99m.
authors.affiliation: Kliniken und Polikliniken für Nuklearmedizin, Westfälische Wilhelms-Universität, Münster, Federal Republic of Germany.
authors.forename: J
authors.initials: J
authors.lastname: Sciuk
authors.forename: C
authors.initials: C
authors.lastname: Puskás
authors.forename: B
authors.initials: B
authors.lastname: Greitemann
authors.forename: O
authors.initials: O
authors.lastname: Schober
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007457:Iodine Radioisotopes; D007720:Knee Prosthesis / Q000009:adverse effects*; D007962:Leukocytes; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging*; D016719:Radioimmunodetection; D013667:Technetium
chemical_list: D007457:Iodine Radioisotopes; D013667:Technetium