Onychomycosis treated with itraconazole or griseofulvin alone with and without a topical antimycotic or keratolytic agent.
An open, comparative, randomized study was conducted using griseofulvin or itraconazole for the treatment of onychomycosis of the foot. Group I (45 patients) received itraconazole and Group II (45 patients) received griseofulvin. Each group was divided into three subgroups that received different topical treatment: antimycotic cream (isoconazole 1%), keratolytic cream (urea 40%), or placebo cream. The itraconazole group showed complete clearance in combination with isoconazole cream in 73.3% (11 of 15 patients), in combination with keratolytic cream in 78.5% (11 of 14 patients), and in combination with placebo cream in 91.6% (11 of 12 patients). The griseofulvin group showed complete clearance in combination with isoconazol cream in 46.1% (7 of 15 patients), in combination with keratolytic cream in 42.8% (6 of 15 patients), and in combination with placebo cream in 26.6% (4 of 15 patients). The itraconazole group showed better results compared with the griseofulvin group when the chi-square statistical method was used.
Arenas
R
R
Departamento de Dermatología, Hospital General Dr. Manuel Gea González, Mexico.
Fernández
G
G
Domínguez
L
L
D000287:Administration, Topical; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004643:Emollients / Q000008:administration & dosage; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy / Q000473:pathology; D006118:Griseofulvin / Q000008:administration & dosage*; D006801:Humans; D017964:Itraconazole; D007641:Keratolytic Agents / Q000008:administration & dosage*; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy* / Q000473:pathology; D011446:Prospective Studies
D000935:Antifungal Agents; D004643:Emollients; D007641:Keratolytic Agents; D017964:Itraconazole; D006118:Griseofulvin; D007654:Ketoconazole