title: [Relationship of antioxidant and anti-ischemic effects of various energy-yielding compounds].
abstract: Influence of fructose++-1,6-diphosphate, succinate, malate and cytochrome C on free lipid peroxidation (FLP), infarct sizes and metabolic acidosis was studied in experiments on rats. The good correlation between inhibition of FLP and cardioprotector activity was established for activators of glycolytic energy production only. Krebs' cycle metabolites limited the zone of myocardial necrosis after coronary occlusion without any significant depression of FLP. Succinate and malate were practically inactive under acute metabolic acidosis of isolated rat heart.
authors.forename: P V
authors.initials: PV
authors.lastname: Sergeev
authors.forename: G V
authors.initials: GV
authors.lastname: Snegireva
authors.forename: V M
authors.initials: VM
authors.lastname: Gukasov
authors.forename: V V
authors.initials: VV
authors.lastname: Gatsura
mesh_terms: D000138:Acidosis / Q000378:metabolism; D000818:Animals; D000975:Antioxidants; D003574:Cytochrome c Group / Q000494:pharmacology* / Q000627:therapeutic use; D004734:Energy Metabolism; D005635:Fructosediphosphates / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation; D008293:Malates / Q000494:pharmacology* / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use; D019802:Succinic Acid
chemical_list: D000975:Antioxidants; D003574:Cytochrome c Group; D005635:Fructosediphosphates; D008293:Malates; D013386:Succinates; C030298:malic acid; D019802:Succinic Acid; C029063:fructose-1,6-diphosphate
vernacular_title: Sootnoshenie antioksidantnogo i protivo-ishemicheskogo éffekt nekotorykh énergoobespechivaiushchikh sredstv.