title: Manifestations of anogenital HPV infection in the male partners of women with anogenital warts and/or abnormal cervical smears.
abstract: The prevalence and manifestations of anogenital human papillomavirus (HPV) infection in 154 men, all of whom were the sexual partners of women with either overt anogenital warts or cervical HPV-related abnormalities, were assessed using clinical, histopathological and molecular criteria. Detailed examination of the anogenital region using a colposcope was supplemented by the use of 5% acetic acid to detect possible foci of subclinical HPV infection. Biopsies of warts and aceto-white lesions were examined histopathologically and by HPV DNA hybridization using radiolabelled HPV 6/11 and 16/18 DNA probes. More than two-thirds of the men had clinical indications of genital HPV infection: 37% had apparent macroscopic warts, almost invariably in combination with aceto-white lesions; while 34% had aceto-white lesions only. The overwhelming majority of these lesions (92%) were located on the penis only. However, only 49% of the macroscopic and 29% of the aceto-white lesions showed histological features consistent with a conclusive diagnosis of HPV infection; while the corresponding figures for HPV DNA positivity were 72% and 56% respectively. Current HPV infection was strongly associated with a past history of anogenital warts, but there was little or no correlation between the manifestations of HPV infection in the male and female sexual partners.
authors.affiliation: Sydney STD Centre, Sydney Hospital, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Law
authors.forename: A
authors.initials: A
authors.lastname: Merianos
authors.forename: C
authors.initials: C
authors.lastname: Thompson
authors.forename: B
authors.initials: B
authors.lastname: Rose
authors.forename: Y
authors.initials: Y
authors.lastname: Cossart
authors.forename: J
authors.initials: J
authors.lastname: Grace
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000453:epidemiology / Q000473:pathology*; D001706:Biopsy; D003218:Condylomata Acuminata / Q000473:pathology; D015344:DNA Probes, HPV; D005260:Female; D005833:Genital Neoplasms, Female / Q000473:pathology; D005834:Genital Neoplasms, Male / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D027383:Papillomaviridae; D012747:Sexual Partners; D012907:Smoking; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000473:pathology* / Q000635:transmission; D014626:Vaginal Smears
chemical_list: D015344:DNA Probes, HPV