Complete disappearance of unresectable hepatoblastoma by continuous infusion therapy through hepatic artery.
A 4-month-old infant with a huge unresectable hepatoblastoma was treated by continuous infusion therapy with 5-fluorouracil, vincristine, Adriamycin, and cisplatin, through the hepatic artery. Following 18 months of chemotherapy, the tumor disappeared completely and the initially sky-high serum alpha-fetoprotein levels returned to normal. At the time of this report, the patient continues to do well without tumor recurrence 6 years following discontinuation of the combination chemotherapy.
Yokomori
K
K
Department of Pediatric Surgery, Japanese Red Cross Medical Center, Tokyo.
Hori
T
T
Asoh
S
S
Tuji
A
A
Takemura
T
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007223:Infant; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil