Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver.
Cardiolipin is a major mitochondrial membrane lipid and plays a vital role in mitochondrial function. The effect of thyroxine on the activity of liver mitochondrial cardiolipin synthase was examined in this study. Treatment with thyroxine (250 micrograms/100 g) for 5 days increased cardiolipin synthase activity by 52%. Mitochondrial levels of cardiolipin appear to be regulated in part by the effect of thyroid hormone on the activity of cardiolipin synthase.
Hostetler
K Y
KY
Department of Medicine, University of California, San Diego.
D000818:Animals; D008297:Male; D008565:Membrane Proteins; D008930:Mitochondria, Liver / Q000201:enzymology*; D010770:Phosphotransferases / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013974:Thyroxine / Q000494:pharmacology*; D017855:Transferases (Other Substituted Phosphate Groups)
D008565:Membrane Proteins; D010770:Phosphotransferases; D017855:Transferases (Other Substituted Phosphate Groups); C100091:cardiolipin synthetase; D013974:Thyroxine