title: [Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia].
abstract: Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.
authors.affiliation: Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U/184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médecine, Strasbourg, France.
authors.forename: P
authors.initials: P
authors.lastname: Kastner
authors.forename: A
authors.initials: A
authors.lastname: Perez
authors.forename: Y
authors.initials: Y
authors.lastname: Lutz
authors.forename: C
authors.initials: C
authors.lastname: Rochette-Egly
authors.forename: M P
authors.initials: MP
authors.lastname: Gaub
authors.forename: P
authors.initials: P
authors.lastname: Chambon
mesh_terms: D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000235:genetics; D015513:Oncogene Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry* / Q000235:genetics; D014212:Tretinoin / Q000737:chemistry* / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; D015513:Oncogene Proteins; D011956:Receptors, Cell Surface; D011993:Recombinant Fusion Proteins; D014212:Tretinoin
vernacular_title: Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes.