title: Nuclear hormone receptor variants: their role in malignancy and progression to hormone resistance in cancer.
abstract: Structural variants of nuclear hormone receptors have been found in tumour tissues. Experimental evidence suggests two ways in which these variants may have oncogenic potential: 1. by suppressing the action of the normal hormone receptor, thereby acting as dominant negative oncogenes; 2. by activating hormone-responsive genes in a hormone-independent manner. These mechanisms may not only contribute to oncogenesis but also to the development of hormone resistance in tumours, e.g. breast and prostate cancer.
authors.affiliation: Division of Tumour Biology, The Netherlands Cancer Institute.
authors.forename: M
authors.initials: M
authors.lastname: Sluyser
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism*; D004351:Drug Resistance; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009857:Oncogenes; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000502:physiology; D011960:Receptors, Estrogen / Q000235:genetics / Q000502:physiology; D014158:Transcription, Genetic
chemical_list: D006728:Hormones; D011956:Receptors, Cell Surface; D011960:Receptors, Estrogen