[Scavenging effects of dimercaptosuccinic acid per os on nickel in mice and rats].
In mice and rats given iv or im 63NiCl2 148-370 kBq, radioactivity was present in highest concentrations in kidney, lung, and liver. After given ig dimercaptosuccinic acid (DMSA) 1 g.kg-1, radioactivity decreased remarkably in kidney, lung, and blood. The excretion of 63Ni via urine and feces within 24 h, respectively 13.0 +/- 2.4% and 0.6 +/- 0.4%, was similar to that in the control group in mice. But radioactivity increased markedly in bone. The Ni content of bone decreased on d 7. In rats given im 63NiCl2 370 kBq, two different nickel complex peaks appeared in the gel chromatograms of serum, kidney, and lung. DMSA reduced the contents of protein-bound Ni in serum, kidney, and lung. The results showed that DMSA detoxified the Ni by forming a low toxicity Ni-DMSA complex to redistribute in the body.
Xu
J
J
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Liang
Y Y
YY
Zhang
J S
JS
Yan
X M
XM
D000818:Animals; D001345:Autoradiography; D001842:Bone and Bones / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D008297:Male; D051379:Mice; D009532:Nickel / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D004113:Succimer / Q000494:pharmacology*; D014018:Tissue Distribution / Q000187:drug effects
D009532:Nickel; D004113:Succimer