title: Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents.
abstract: In order to study the structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential anti-retroviral agents, various purine derivatives have been synthesized and tested against rous sarcoma virus (RSV) in chick embryo fibroblast (CEF) cells, and against human immunodeficiency virus (HIV) in human CD4+ T cells (ATH8). Some of the new purine derivatives found to be significant antiretroviral activities. And the correlations of activity between anti-RSV and anti-HIV have shown fairly good values so far.
authors.affiliation: Research Laboratory of Bioresources, Sanyo-Kokusaku Pulp Co. Ltd, Iwakuni, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Kojima
authors.forename: T
authors.initials: T
authors.lastname: Shirasaka
authors.forename: M
authors.initials: M
authors.lastname: Machida
authors.forename: H
authors.initials: H
authors.lastname: Yoshioka
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: H
authors.initials: H
authors.lastname: Mitsuya
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001358:Avian Sarcoma Viruses / Q000187:drug effects*; D002460:Cell Line; D002642:Chick Embryo; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D006678:HIV / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides