The effect of acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats.
The intestinal transport of D-xylose was studied during the acute poisoning of male Wistar rats with orally administered potassium nitrate and sodium nitrite. At the peak of xylose absorption, the metabolic parameters of Na+/K(+)-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level were determined in the small intestine mucosa. Nitrite in a dose of 80 mg NaNO2/kg b.w. increased the permeability of gastric mucosa for D-xylose and raised the uptake of oxygen by the small intestine mucosa. No changes were observed in the activity of Na+/K(+)-ATPase and alkaline phosphatase. A dose of 10 mg NaNO2/kg b.w. was not followed by increased absorption of this sugar. It was also demonstrated that potassium nitrate had no effect on the process of intestinal absorption of D-xylose and failed to change the determined metabolic parameters of the small intestine mucosa.
Grudziński
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Department of Food Studies and Nutrition Physiology, Military Institute of Hygiene and Physiology, Warsaw, Poland.
Szymański
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A
D000284:Administration, Oral; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D010101:Oxygen Consumption; D017680:Potassium Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012977:Sodium Nitrite / Q000494:pharmacology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014994:Xylose / Q000493:pharmacokinetics*
D009566:Nitrates; D017680:Potassium Compounds; D014994:Xylose; D000254:Sodium-Potassium-Exchanging ATPase; D012977:Sodium Nitrite; C023844:potassium nitrate