Molecular recognition and targeting of lysosomal proteins.
Recent studies have established that in mammalian cells insulin-like growth factor-II can couple the large mannose-6-phosphate receptor to a GTP-binding protein and that the insulin-like growth factor-II-induced activation of the GTP-binding protein is inhibited by mannose-6-phosphate and lysosomal enzymes. In mouse, the gene for the large mannose-6-phosphate receptor is maternally imprinted.
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Georg-August-Universitat, Göttingen, Germany.
D000818:Animals; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D005314:Embryonic and Fetal Development; D004798:Enzymes / Q000378:metabolism / Q000494:pharmacology; D005656:Fungal Proteins / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D005804:Genes, Lethal; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000037:antagonists & inhibitors / Q000502:physiology*; D008247:Lysosomes / Q000378:metabolism*; D008322:Mammals / Q000378:metabolism; D008360:Mannosephosphates / Q000378:metabolism* / Q000494:pharmacology; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice / Q000196:embryology / Q000235:genetics; D009081:Mucolipidoses / Q000378:metabolism; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D004798:Enzymes; D005656:Fungal Proteins; D008360:Mannosephosphates; D008565:Membrane Proteins; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface; C027693:mannose-6-phosphate; D007335:Insulin-Like Growth Factor II; D010770:Phosphotransferases; D011494:Protein Kinases; D019204:GTP-Binding Proteins