Peripheral benzodiazepine receptors on platelets in chronic and detoxified alcoholics.
The effect of chronic alcoholism and detoxification treatment with disulfiram on platelet peripheral benzodiazepine receptors was studied in alcoholic males. Chronic consumption of alcohol did not alter the binding values for [3H]PK 11195, as compared to non-alcoholics. Treatment for 3 weeks with disulfiram resulted in a significant increase in the density of peripheral benzodiazepine receptors, with no alteration in the affinity of these sites to the ligand. These results might be relevant to the cellular and metabolic effects of disulfiram.
Karp
L
L
Geha Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Israel.
Weizman
A
A
Fliman
M
M
Tyano
S
S
Gavish
M
M
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000523:psychology; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004221:Disulfiram / Q000494:pharmacology; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011963:Receptors, GABA-A / Q000378:metabolism*
D007546:Isoquinolines; D011963:Receptors, GABA-A; D004221:Disulfiram; C037850:PK 11195