Neuroendocrine tumors of the larynx.
A review of the international literature has revealed 68 paragangliomas, 42 large cell, and 74 small cell tumors of the larynx. Paragangliomas are usually benign, although malignant cases have been reported. Large cell tumors are malignancies associated with a high incidence of early cervical metastasis. Small cell tumors are aggressive cancers characterized by early, diffuse metastatic disease. All three neoplasms demonstrate a propensity for the supraglottic larynx. While surgery remains the treatment of choice for paragangliomas and large cell cancers, small cell cancers are best treated by radiotherapy and chemotherapy. The determinate 5-year survival for patients with paragangliomas, large cell, and small cell cancers is 60%, 34%, and 14%, respectively. While representing distinct clinical entities, these neoplasms demonstrate similar ultrastructural and histochemical features and should be classified as neuroendocrine tumors of the larynx (NETL). A comprehensive analysis of these laryngeal tumors is presented herein. Their clinical behavior and management options are reviewed and a scheme for their nomenclature and classification is proposed.
Moisa
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Department of Surgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000145:classification / Q000473:pathology / Q000628:therapy / Q000648:ultrastructure; D018288:Carcinoma, Small Cell / Q000145:classification / Q000473:pathology / Q000628:therapy / Q000648:ultrastructure; D002648:Child; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000145:classification / Q000473:pathology / Q000628:therapy / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology / Q000648:ultrastructure; D010235:Paraganglioma / Q000145:classification / Q000473:pathology / Q000628:therapy / Q000648:ultrastructure