title: A study on changes of coagulation inhibitors and fibrinolysis inhibitors in patients with liver cirrhosis and hepatoma.
abstract: The authors conducted an investigation focusing mainly on the activities of the inhibitory factors of the coagulation and fibrinolysis processes in 35 normal adults and 72 liver cirrhosis and/or hepatoma patients. The activities of antithrombin III, protein C, and alpha 2-plasmin inhibitor were reduced to less than 50% in patients with decreased hepatic synthetic function while lupus anticoagulant was detected in more than 50% of patients with decreased hepatic synthetic function. Hemostatic abnormalities in advanced lived diseases may be caused partly by a decrease of coagulation and fibrinolysis inhibitors and the presence of lupus anticoagulant.
authors.affiliation: Department of Clinical Pathology, College of Medicine, Hallym University, Seoul, Korea.
authors.forename: C J
authors.initials: CJ
authors.lastname: Park
authors.forename: H I
authors.initials: HI
authors.lastname: Cho
authors.forename: S I
authors.initials: SI
authors.lastname: Kim
mesh_terms: D000328:Adult; D000933:Antifibrinolytic Agents / Q000097:blood; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000097:blood*; D006487:Hemostasis; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood*; D016682:Lupus Coagulation Inhibitor
chemical_list: D000933:Antifibrinolytic Agents; D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor