title: Effects of selective histamine H3-receptor ligands on prolactin and growth hormone secretion in the rat.
abstract: The effects of intracarotid (i.a.) administration of the histamine (HA) H3-receptor agonist (R)-alpha-methyl-histamine (alpha MeHA) and of the H3-antagonist thioperamide, (THIO) on basal or morphine (M)-induced prolactin (PRL) and growth hormone (GH) secretion were studied in male rats. M was administered 3 h after the H3-drugs. Neither THIO (2.5 mg/kg) nor alpha MeHA (10 mg/kg) changed basal PRL levels and only THIO enhanced the PRL-releasing effect of M (6 mg/kg). Basal GH secretion was not modified by THIO. alpha MeHA slightly increased GH secretion. THIO significantly decreased M-stimulated GH secretion (1 mg/kg, i.a.) and alpha MeHA slightly increased it. These results, in agreement with previous evidence obtained after central HA administration, indicated that endogenous brain HA facilitates PRL and inhibits GH secretion.
authors.affiliation: Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Netti
authors.forename: F
authors.initials: F
authors.lastname: Guidobono
authors.forename: V
authors.initials: V
authors.lastname: Sibilia
authors.forename: F
authors.initials: F
authors.lastname: Pagani
authors.forename: I
authors.initials: I
authors.lastname: Villa
authors.forename: A
authors.initials: A
authors.lastname: Pecile
mesh_terms: D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D006633:Histamine Antagonists; D007700:Kinetics; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011968:Receptors, Histamine / Q000502:physiology*; D018100:Receptors, Histamine H3
chemical_list: D006633:Histamine Antagonists; D008761:Methylhistamines; D010880:Piperidines; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; C069357:alpha-methylhistamine; D009020:Morphine; D011388:Prolactin; D013006:Growth Hormone; C052075:thioperamide