Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II.
Pedersen-Bjergaard
J
J
Philip
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D002880:Chromosomes, Human, Pair 11; D002891:Chromosomes, Human, Pair 21; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D009436:Neural Tube Defects / Q000188:drug therapy / Q000235:genetics*; D059005:Topoisomerase II Inhibitors; D014178:Translocation, Genetic
D059005:Topoisomerase II Inhibitors