Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter.
A human parvovirus, adeno-associated virus (AAV), is unique among eukaryotic DNA viruses in its ability to integrate site specifically into a defined region of human chromosome 19. In this study we used in situ hybridization to visualized directly the site of AAV DNA integration in latently infected human cell lines and normal human cells.
Kotin
R M
RM
Department of Microbiology, Hearst Microbiology Research Center, Cornell University Medical College, New York, New York 10021.
Menninger
J C
JC
Ward
D C
DC
Berns
K I
KI
D001483:Base Sequence; D002460:Cell Line; D002888:Chromosomes, Human, Pair 19; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D000229:Dependovirus / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D004279:DNA, Viral