title: Demyelinating peripheral neuropathy in Devic disease.
abstract: This is a report of a 20-year-old man with typical features of Devic disease (neuromyelitis optica) associated with demyelinating peripheral neuropathy. A sural nerve biopsy showed markedly decreased myelinated fibers of a large diameter. Teased fiber preparations showed segmental remyelination in 50% of examined fibers, as well as a few demyelination. Demyelination of bilateral optic nerves, spinal cord, and peripheral nerves at the same time suggests a possibility of common pathogenetic mechanisms in both the central and peripheral nervous systems.
authors.affiliation: Department of Neurology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Aimoto
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: F
authors.initials: F
authors.lastname: Moriwaka
authors.forename: K
authors.initials: K
authors.lastname: Tashiro
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D000328:Adult; D001706:Biopsy; D002493:Central Nervous System Diseases / Q000175:diagnosis; D003711:Demyelinating Diseases / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009471:Neuromyelitis Optica / Q000150:complications / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology