Effects of endothelin on adrenergic neurotransmission in the dog kidney.
Endothelin infused into the renal artery (0.3-3 ng/kg per min) of anesthetized dogs suppressed the increases in renal venous plasma norepinephrine (NE) concentration and calculated NE efflux induced by renal nerve stimulation at low frequencies (0.7-1.2 Hz) but not at high frequencies (2-3.5 Hz). Endothelin failed to affect the decrease in renal blood flow induced by renal nerve stimulation or exogenous NE. These findings suggest that endothelin inhibits NE release during a slight rise in renal nerve activity, while it does not affect alpha-adrenoceptor-mediated vasoconstriction in the dog kidney.
Takagi
H
H
Department of Pharmacology, Tohoku University, Sendai, Japan.
Hisa
H
H
Satoh
S
S
D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D016232:Endothelins / Q000494:pharmacology* / Q000502:physiology; D004837:Epinephrine / Q000502:physiology; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D012079:Renal Circulation / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D016232:Endothelins; D009638:Norepinephrine; D004837:Epinephrine