title: [A case of smoldering adult T-cell leukemia complicated by various pulmonary infections].
abstract: A 46-year-old man was admitted to Oita Medical College Hospital on October 16, 1987, because of cough and sputum. Chest X-ray and chest CT films showed diffuse reticulonodular shadow. The specimens obtained by transbronchial lung biopsy revealed cysts of pneumocystis carinii. Abnormal lymphocytes with lobulated nuclei were found 2-7% of peripheral leucocytes. The anti HTLV-I antibody was positive. According to these data, we diagnosed the patient as smoldering adult T cell leukemia with pneumocystis carinii pneumonia. The abnormal shadow on chest X-ray disappeared after SMX-TMP and pentamidine treatment. After about 1 year, he was again admitted for high fever. Chest X-ray showed infiltration with cavity in right upper lobe. Streptococcus pneumoniae was isolated from the sputum. The infiltration shadow on chest X-ray disappeared after antibiotics treatment. However, multiple nodular shadow appeared on the chest X-ray and ATL cell infiltration was found in the specimens of transbronchial lung biopsy. ATL cells in peripheral blood also increased and serum LDH and Calcium levels were markedly high. According to these data, we diagnosed the patient as having a ATL crisis. Although chemotherapy for ATL was started, the ATL, cell infiltration shadow on the chest X-ray enlarged, and bilateral diffuse patchy shadows was appeared on the chest X-ray. He died of respiratory failure on April 26, 1989. Cytomegalovirus pneumonia and ATL cell infiltration were revealed by necropsy.
authors.affiliation: Second Department of Internal Medicine, Medical College of Oita.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamakami
authors.forename: T
authors.initials: T
authors.lastname: Tashiro
authors.forename: T
authors.initials: T
authors.lastname: Kouno
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: K
authors.initials: K
authors.lastname: Ono
authors.forename: H
authors.initials: H
authors.lastname: Nagai
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Nasu
mesh_terms: D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications*; D003586:Cytomegalovirus Infections / Q000150:complications; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications*; D011018:Pneumonia, Pneumococcal / Q000150:complications; D011020:Pneumonia, Pneumocystis / Q000150:complications; D011024:Pneumonia, Viral / Q000150:complications