Effect of pepsin on the kinetics of HCl neutralization by dihydroxyaluminum sodium carbonate, hydrotalcite and dihydroxyaluminum aminoacetate.
The rate of HCl neutralization by dihydroxyaluminum sodium carbonate (DHASC), hydrotalcite (HT) and dihydroxyaluminum aminoacetate (DHAAA) in the presence of different amount of pepsin (PP) has been studied at constant pH = 3.0. The results can be explained using Weibull distribution function by comparing the kinetical parameters with and without the substance added and as a function of their concentration. Some aspects of mechanisms of inhibition or acceleration of acid neutralization of DHASC, HT and DHAAA by PP are also discussed.
Kokot
Z J
ZJ
Department of Inorganic and Analytical Chemistry, School of Medicine, Poznań, Poland.
D000536:Aluminum Hydroxide / Q000737:chemistry / Q000493:pharmacokinetics; D000863:Antacids / Q000737:chemistry* / Q000493:pharmacokinetics*; D005998:Glycine / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D006851:Hydrochloric Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008276:Magnesium Hydroxide / Q000737:chemistry / Q000493:pharmacokinetics; D010434:Pepsin A / Q000494:pharmacology*
D000863:Antacids; C010467:hydrotalcite; D000536:Aluminum Hydroxide; C016386:dihydroxyaluminum sodium carbonate; C007420:dihydroxyaluminum aminoacetate; D010434:Pepsin A; D008276:Magnesium Hydroxide; D006851:Hydrochloric Acid; D005998:Glycine