Ro 24-5913: a potent, specific, orally active LTD4 antagonist.
O'Donnell
M
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Department of Pharmacology, Hoffmann-La Roche, Inc., Nutley, New Jersey 07110.
D000284:Administration, Oral; D000336:Aerosols; D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000502:physiology*; D016084:Bronchoconstriction / Q000187:drug effects*; D006168:Guinea Pigs; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D011971:Receptors, Immunologic / Q000187:drug effects / Q000378:metabolism; D018077:Receptors, Leukotriene; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000502:physiology*
D000336:Aerosols; D011971:Receptors, Immunologic; D018077:Receptors, Leukotriene; D013189:SRS-A; D013844:Thiazoles; C071436:cinalukast