[Relationship of antioxidant and anti-ischemic effects of various energy-yielding compounds].
Influence of fructose++-1,6-diphosphate, succinate, malate and cytochrome C on free lipid peroxidation (FLP), infarct sizes and metabolic acidosis was studied in experiments on rats. The good correlation between inhibition of FLP and cardioprotector activity was established for activators of glycolytic energy production only. Krebs' cycle metabolites limited the zone of myocardial necrosis after coronary occlusion without any significant depression of FLP. Succinate and malate were practically inactive under acute metabolic acidosis of isolated rat heart.
Sergeev
P V
PV
Snegireva
G V
GV
Gukasov
V M
VM
Gatsura
V V
VV
D000138:Acidosis / Q000378:metabolism; D000818:Animals; D000975:Antioxidants; D003574:Cytochrome c Group / Q000494:pharmacology* / Q000627:therapeutic use; D004734:Energy Metabolism; D005635:Fructosediphosphates / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation; D008293:Malates / Q000494:pharmacology* / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism*; D051381:Rats; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use; D019802:Succinic Acid
D000975:Antioxidants; D003574:Cytochrome c Group; D005635:Fructosediphosphates; D008293:Malates; D013386:Succinates; C030298:malic acid; D019802:Succinic Acid; C029063:fructose-1,6-diphosphate
Sootnoshenie antioksidantnogo i protivo-ishemicheskogo éffekt nekotorykh énergoobespechivaiushchikh sredstv.