[Changes in the cerebrospinal fluid levels of adenosine cyclic- 3',5'-monophosphate (c-AMP) in patients with generalized tonic-clonic epileptic seizures].
Authors evaluated the activity of c-AMP in the CSF as the biochemical marker for evaluation of epileptic seizure activity in patients with epilepsy. The impact of monitored phenytoin treatment on c-AMP activity in CSF was investigated. It was shown that the general tonic-clonic seizures cause a significant concentration increase of c-AMP in CSF. Monitored phenytoin treatment had a stabilizing effect on c-AMP activity in CSF.
Szczechowski
L
L
Katedra i Klinika Neurologii Slaskiej Akademii.
Wajgt
A
A
Marczewska
E
E
D000293:Adolescent; D000328:Adult; D000242:Cyclic AMP / Q000037:antagonists & inhibitors / Q000134:cerebrospinal fluid*; D003864:Depression, Chemical; D016903:Drug Monitoring; D004830:Epilepsy, Tonic-Clonic / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010672:Phenytoin / Q000008:administration & dosage*; D013997:Time Factors
D010672:Phenytoin; D000242:Cyclic AMP
Zmiany stezenia cyklicznego adenozyno 3'5' monofosforanu (c-AMP) w płynie mózgowo rdzeniowym (p.m.r.) u chorych z uogólnionymi toniczno-klonicznymi napadami padaczki.