[The effect of L-serine-O-phosphate on synaptic transmission in the afferent synapses of the ampullae of Lorenzini in skates].
Effect of bath-application of L-serine-O-phosphate (SOP) on the resting and evoked activity as well as on responses elicited by L-glutamate (L-GLU), quisqualate (Q), kainate (KA) and N-methyl-D-aspartate (NMDA) were studied at the level of afferent synapses of the ampullae of Lorenzini. SOP blocked the synaptic transmission (threshold concentration 10(-7) mol/l) and inhibited responses elicited by application of L-GLU and NMDA, while Q- and KA-induced responses remained unchanged. The data obtained permit supposing that inhibitory effects of SOP in the afferent synapses of the ampullae of Lorenzini are associated with its action on membrane receptors of the NMDA type.
Akoev
G N
GN
Andrianov
Iu N
IuN
Ryzhova
I V
IV
Sherman
N O
NO
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D010477:Perfusion / Q000379:methods; D010768:Phosphoserine / Q000494:pharmacology*; D012860:Skates, Fish / Q000502:physiology*; D013569:Synapses / Q000187:drug effects* / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D010768:Phosphoserine
Vliianie L-serin-O-fosfata na sinapticheskuiu peredachu v afferentnykh sinapsakh ampul Lorentsini skatov.