title: Serial P-31 MR spectroscopy after fructose infusion in patients with chronic hepatitis.
abstract: Serial changes in phosphorus metabolites after intravenous administration of fructose were compared between five healthy volunteers and five patients with chronic hepatitis by means of phosphorus-31 magnetic resonance (MR) spectroscopy. P-31 spectra were obtained every 5 minutes after intravenous drip infusion of 20% fructose at a dose of 0.5 g/kg of body weight. In the healthy volunteers, phosphomonoesters (PME) increased to 338% +/- 76% of the preadministration value at 15-20 minutes. Inorganic phosphate (Pi) was depleted in the first 15 minutes, then rebounded to 260% +/- 67% of the initial value. beta-adenosine triphosphate decreased to less than 50% of its initial value and then gradually recovered. In patients with chronic hepatitis, the increase of PME at 15-20 minutes (151% +/- 49% of the preadministration value) was significantly less than that in healthy volunteers (P less than .05). In addition, the rebound of Pi at 35-40 minutes (126% +/- 42%) was significantly less than that in healthy volunteers (P less than .05). In conclusion, P-31 MR spectroscopy with fructose administration is valuable in the functional evaluation of diffuse liver diseases.
authors.affiliation: Department of Radiology, Mie University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakuma
authors.forename: K
authors.initials: K
authors.lastname: Itabashi
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: Y
authors.initials: Y
authors.lastname: Kinosada
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D005632:Fructose / Q000378:metabolism*; D005636:Fructosephosphates / Q000378:metabolism; D006509:Hepatitis B / Q000378:metabolism*; D006526:Hepatitis C / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism
chemical_list: D005636:Fructosephosphates; C032284:fructose-1-phosphate; D010758:Phosphorus; D005632:Fructose; D000255:Adenosine Triphosphate; D010744:Phosphoric Monoester Hydrolases