title: Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen in atrophic gastritis and rheumatoid arthritis.
abstract: The occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen was analysed by means of enzyme-linked immunosorbent assay in three groups of sera. Group 1 comprised sera from 14 rheumatoid arthritis patients with normal acid secretion; group 2, sera from 18 rheumatoid arthritis patients with reduced acid secretion; and group 3, sera from 11 patients with pernicious anaemia or achylia. Groups 1 and 2 were rheumatoid factor-positive, and group 3 was negative. Intrinsic factor autoantibodies were low in groups 1 and 2. In group 3, 9 of the 11 sera (82%) scored positive. The highest titres of H,K-ATPase and pepsinogen autoantibodies were found in groups 2 and 3. Only one serum in group 1 scored positive against H,K-ATPase, and two against pepsinogen, whereas corresponding values were 11 (61%) and 7 (39%) in group 2, and 10 (91%) and 6 (55%) in group 3. Autoantibodies against H,K-ATPase from a pool of patient sera recognized both the alpha- and beta-subunits of the enzyme. The present results support the hypothesis of an autoimmune disease overlap between non-organ-specific rheumatoid arthritis and organ-specific pernicious anaemia.
authors.affiliation: Dept. of Medical and Physiological Chemistry, Uppsala University, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Mårdh
authors.forename: J Y
authors.initials: JY
authors.lastname: Ma
authors.forename: Y H
authors.initials: YH
authors.lastname: Song
authors.forename: A
authors.initials: A
authors.lastname: Aly
authors.forename: K
authors.initials: K
authors.lastname: Henriksson
mesh_terms: D000251:Adenosine Triphosphatases / Q000276:immunology*; D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005757:Gastritis, Atrophic / Q000276:immunology*; D017506:H(+)-K(+)-Exchanging ATPase; D006801:Humans; D007437:Intrinsic Factor / Q000276:immunology; D008875:Middle Aged; D010435:Pepsinogens / Q000276:immunology
chemical_list: D001323:Autoantibodies; D010435:Pepsinogens; D007437:Intrinsic Factor; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase