Observations and an interpretation of dose-response relationships for cellular transformation in terms of induced (T) repair.
Both radiation-induced lethality and transformation frequency have been observed to plateau or diminish abruptly at relatively low dose levels and then increase with increasing doses, but at a reduced incremental rate. Discontinuities in dose-response relationships are postulated to correspond to the induction of a repair system ('T' repair) not functional at lower doses, i.e. below the induction threshold dose (Tt). Anomalies (discontinuities) in dose-response relationships and effects of dose fractionation previously noted are qualitatively explained in terms of this model.
Calkins
J
J
Department of Biomedical Physics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Einspenner
M
M
Azzam
E
E
Kunhi
M
M
Sigut
D
D
Hannan
M
M
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects*; D003037:Cobalt Radioisotopes; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D066298:In Vitro Techniques; D051379:Mice; D009502:Neutrons; D012062:Relative Biological Effectiveness
D003037:Cobalt Radioisotopes