title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene.
abstract: We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.
authors.affiliation: Department of Pharmacology, Stanford University School of Medicine, CA 94305.
authors.forename: A E
authors.initials: AE
authors.lastname: Lusska
authors.forename: K W
authors.initials: KW
authors.lastname: Jones
authors.forename: C J
authors.initials: CJ
authors.lastname: Elferink
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.forename: E S
authors.initials: ES
authors.lastname: Shen
authors.forename: L P
authors.initials: LP
authors.lastname: Wen
authors.forename: J P
authors.initials: JP
authors.lastname: Whitlock
mesh_terms: D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis / Q000235:genetics*; D002460:Cell Line; D002843:Chromatin / Q000187:drug effects / Q000502:physiology; D004742:Enhancer Elements, Genetic / Q000187:drug effects; D004790:Enzyme Induction; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental; D051379:Mice; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000187:drug effects / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D002843:Chromatin; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; D001189:Aryl Hydrocarbon Hydroxylases