Effects of hypertension on arterial gene expression and atherosclerosis.
Hypertension and antihypertensive drugs can lead to a number of structural and functional alterations in the arterial wall. The recent studies that have been summarized in this paper have emphasized primarily the work being performed in my own laboratory, and have not attempted to review thoroughly the exciting research now taking place in this field. However, they do illustrate the fact that studies involving vascular injury and atherosclerosis have begun to change in focus to emphasize the cellular and molecular mechanisms that are responsible for the pathologic changes that develop. Such investigations ultimately should lead to improved methods for the prevention or treatment of the vascular consequences of hypertension.
Chobanian
A V
AV
Boston University School of Medicine, MA 02118.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D015870:Gene Expression; D006973:Hypertension / Q000150:complications* / Q000235:genetics / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000201:enzymology / Q000473:pathology; D000254:Sodium-Potassium-Exchanging ATPase / Q000235:genetics
D000959:Antihypertensive Agents; D000254:Sodium-Potassium-Exchanging ATPase