title: Comparative effects of heparin and LMW heparin on hemostasis.
abstract: We performed studies to investigate the effect of protamine sulfate neutralization on both the anticoagulant and hemostatic effects of enoxaparin and heparin. Although the anti-Factor Xa effect of enoxaparin was incompletely neutralized by protamine sulfate in an experimental animal model, protamine sulfate reversed bleeding induced by hemorrhagic doses of enoxaparin.
authors.affiliation: Department of Pathology, McMaster University, Hamilton, Ont.
authors.forename: J
authors.initials: J
authors.lastname: Hirsh
authors.forename: M R
authors.initials: MR
authors.lastname: Buchanan
mesh_terms: D000818:Animals; D000990:Antithrombin III / Q000037:antagonists & inhibitors / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors; D004423:Ear / Q000293:injuries; D004789:Enzyme Activation / Q000187:drug effects; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006494:Heparin Antagonists / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D009844:Oligosaccharides / Q000378:metabolism; D011479:Protamines / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation / Q000187:drug effects; D011817:Rabbits; D013917:Thrombin / Q000378:metabolism; D014951:Wounds, Stab / Q000150:complications
chemical_list: D001779:Blood Coagulation Factors; D006494:Heparin Antagonists; D006495:Heparin, Low-Molecular-Weight; D009844:Oligosaccharides; D011479:Protamines; C049714:IC 831423; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin