[The effect of short-chain aliphatic alcohols on electrophysiologic characteristics of muscle cells and neuromuscular transmission in the rat diaphragm].
Effects of short-chain aliphatic alcohols C1-C3 on the rest potential, entrance membranous resistance and spontaneous activity of the neuromuscle synapse of the muscle cells of the diaphragm of the Wistar rats have been studied. The standard electrophysiologic method of intracellular recording was used. Taking into account effects of the increased chain length on the studied parameters, the equimolar alcohol concentrations (0.2 M) were used. The studied alcohols have caused increased rest potential as well as the entrance membranous resistance of the muscle cell. They cause increased spontaneous activity of the neuromuscular synapse and later the shape of the postsynaptic signals. The effects are more manifested if the alcohol chain is longer.
Malicević
Z
Z
Vojnomedicinska akademija, Medicinski fakultet, Tuzla.
Kojić
L
L
Dragić
S
S
Stamenović
B
B
D000433:1-Propanol / Q000494:pharmacology; D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D003964:Diaphragm / Q000294:innervation / Q000502:physiology; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D000432:Methanol / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects / Q000294:innervation / Q000502:physiology*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*
D000438:Alcohols; D000431:Ethanol; D000433:1-Propanol; D000432:Methanol
Uticaj kratkolancanih alifaticnih alkohola na elektrofizioloske karakteristike misićnih ćelija i neuromisićnu transmisiju dijafragme pacova.