title: Evaluation of superoxide scavenging activity of OPC-14117 by electron spin resonance technique.
abstract: OPC-14117 is a potent drug which has both brain function activating effect and protective effect against cerebral ischemia. Occurrences of these effects might be expected due to superoxide dismutase-like activity of OPC-14117. The present study has been conducted to evaluate the active oxygen scavenging activity of OPC-14117 and to explain the mechanisms of its pharmacological activities. The reaction of OPC-14117 and superoxide anion, generated in potassium superoxide, was examined by electron spin resonance technique at both liquid nitrogen (77 K) and room (22 degrees C) temperatures. OPC-14117 showed a higher superoxide scavenging activity than that of alpha-tocopherol in an aprotic solvent system. The active moiety of OPC-14117 to provide the scavenging effect was found due to the phenolic hydroxyl group of its indan skeleton.
authors.affiliation: Research Institute of Otsuka Pharmaceuticals Co., Ltd., Tokushima, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Jinno
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Oshiro
authors.forename: T
authors.initials: T
authors.lastname: Kikuchi
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers; D005615:Freezing; D007189:Indans; D007202:Indicators and Reagents; D010879:Piperazines; D013481:Superoxides
chemical_list: D016166:Free Radical Scavengers; D007189:Indans; D007202:Indicators and Reagents; D010879:Piperazines; D013481:Superoxides; C074852:OPC 14117