[The antiblastic properties of reumycin (experimental research)].
The work deals with the results of study of the antineoplastic activity of a Soviet produced antineoplastic antibiotic reumycin in relation to 35 glial tumors of various degrees of malignancy in primary cultures and in heterotransplantation under the capsule of kidneys in mice. In tissue cultures 71.5% of gliomas were sensitive to reumycin, in the subcapsular test 75% of tumors proved to be reumycin sensitive with fluctuations of inhibited growth of heterotransplants within a range of 27-75%. Among the reumycin resistant tumors, the cultures of one of the glioblastomas showed stimulation of proliferation, which justifies the necessity for testing the individual sensitivity of the tumor to reumycin in each concrete patient.
Romodanov
S A
SA
Semenova
V M
VM
Oleĭnik
G M
GM
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D001254:Astrocytoma / Q000188:drug therapy; D001932:Brain Neoplasms / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005909:Glioblastoma / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D013370:Subrenal Capsule Assay; D014227:Triazines / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D014227:Triazines; C009169:reumycin
Antiblasticheskie svoĭstva reumitsina (éksperimental'noe issledovanie).