title: Upregulation of rat brain opioid receptors by the chronic administration of morphine: possible evidence for an anti-opiate model of tolerance and dependence.
authors.affiliation: Unit on Receptor Studies, LMC, NIDDK, Bethesda, MD 20892.
authors.forename: R B
authors.initials: RB
authors.lastname: Rothman
authors.forename: H Y
authors.initials: HY
authors.lastname: Yang
authors.forename: J B
authors.initials: JB
authors.lastname: Long
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004361:Drug Tolerance; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000276:immunology / Q000494:pharmacology; D007074:Immunoglobulin G / Q000276:immunology; D007276:Injections, Intraventricular; D008024:Ligands; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000503:physiopathology*; D009842:Oligopeptides / Q000276:immunology / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D004745:Enkephalins; D007074:Immunoglobulin G; D008024:Ligands; D009842:Oligopeptides; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009020:Morphine; C053651:phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide