title: Plasma levels of soluble thrombomodulin increase in cases of disseminated intravascular coagulation with organ failure.
abstract: We examined the changes in plasma levels of soluble thrombomodulin in 66 cases of disseminated intravascular coagulation (DIC), to investigate the damage to vascular endothelial cells and its relationship to multiple organ failure. A significant elevation of plasma levels of soluble thrombomodulin was observed in most cases of DIC, especially in patients with sepsis. However, no such significant elevation was observed in patients with acute promyelocytic leukemia. Plasma levels of both soluble thrombomodulin and active plasminogen activator inhibitor were higher in the cases of DIC with multiple organ failure than in those without multiple organ failure. The levels of soluble thrombomodulin were decreased with the clinical improvement in most cases of DIC but were further increased or remained at high levels in patients who showed no improvement of DIC. It was suggested that an increase in soluble thrombomodulin indicates the damage to the vascular endothelial cells in cases of DIC and that the damage to vascular endothelial cells plays some role in further progression of multiple organ failure.
authors.affiliation: Department of Internal Medicine (III), Kanazawa University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Asakura
authors.forename: H
authors.initials: H
authors.lastname: Jokaji
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: C
authors.initials: C
authors.lastname: Uotani
authors.forename: I
authors.initials: I
authors.lastname: Kumabashiri
authors.forename: E
authors.initials: E
authors.lastname: Morishita
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D009102:Multiple Organ Failure / Q000097:blood* / Q000503:physiopathology; D015849:Plasminogen Inactivators / Q000097:blood; D011517:Prothrombin Time; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D018179:Receptors, Thrombin; D012995:Solubility
chemical_list: D015849:Plasminogen Inactivators; D011956:Receptors, Cell Surface; D018179:Receptors, Thrombin