Surgical pathology of the pituitary in Cushing's disease.
The frequency and the significance of the 3 main features of pituitary in Cushing's disease (ACTH secreting adenomas, ACTH cell hyperplasia, and Crooke's cells) are reported and discussed. In our most recent surgical series (1989-1990) the rate of demonstration of adenoma increased up to 96%. The frequency of paraadenomatous ACTH cell hyperplasia depends on the amount of resected tumor-free tissue. The significance of such peritumorous hyperplasia seems to be low. Crooke's cells as suppressed and transformed ACTH cells were present in each case and are a reliable indicator of a hypercortisolism.
Saeger
W
W
Department of Pathology, Marienkrankenhaus, Hamburg, FRG.
D000236:Adenoma / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D003480:Cushing Syndrome / Q000473:pathology* / Q000601:surgery; D006801:Humans; D006965:Hyperplasia; D010902:Pituitary Gland / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000378:metabolism
D000324:Adrenocorticotropic Hormone