title: Sodium deficient rats are unmotivated by sodium chloride solutions mixed with the sodium channel blocker amiloride.
abstract: Rats were made sodium deficient by furosemide injection and then offered 20 min of access to 0.05 M NaCl mixed with the sodium channel blocker amiloride. Compared with a sodium deficient control group that was also offered 0.05 M NaCl, these rats drank very little. A subsequent test conducted in the same manner with 20 min of access to 0.3 M NaCl mixed with amiloride produced similar results. It is concluded that amiloride blocks the neural information required for generating the attractive taste of NaCl to the sodium deficient rat.
authors.affiliation: Department of Psychology, University at Albany, State University of New York 12222.
authors.forename: N B
authors.initials: NB
authors.lastname: McCutcheon
mesh_terms: D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D008297:Male; D009042:Motivation; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage*; D015222:Sodium Channels / Q000187:drug effects*; D013649:Taste / Q000187:drug effects*; D013650:Taste Buds / Q000187:drug effects*; D013652:Taste Threshold / Q000187:drug effects; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D012462:Saline Solution, Hypertonic; D015222:Sodium Channels; D000584:Amiloride