[The antigenic properties of hepatitis A virus particles possessing different physicochemical characteristics].
A modified enzyme immunoassay based on adsorption of antihepatitis A virus (HAV) IgG-HRPO conjugate and monoclonal antibodies to HAV were used to investigate antigenic differences between mature HAV virions and subviral particles with different buoyant densities in CsCl produced in HAV-infected cells. The mature virions (1.34 g/cm3) appeared to have common antigenic determinants with subviral particles (1.20, 1.27, and 1.30 g/cm3) and possess some additional determinants. Nevertheless, both subviral particles and mature virions induced antibodies capable of neutralizing HAV infectivity in tissue culture.
Kusov
Iu Iu
IuIu
Nastashenko
T A
TA
Kazachkov
Iu A
IuA
Donets
M A
MA
Grishina
G K
GK
Berkova
N P
NP
Balaian
M S
MS
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood / Q000276:immunology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006168:Guinea Pigs; D006507:Hepatovirus / Q000276:immunology*; D007114:Immunization; D007124:Immunoenzyme Techniques; D009500:Neutralization Tests; D011817:Rabbits; D014771:Virion / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral
Antigennye svoĭstva chastits virusa gepatita A, obladaiushchikh razlichnymi fiziko-khimicheskimi kharakteristikami.