Nedocromil sodium inhibits airway hyperresponsiveness and eosinophilic infiltration induced by repeated antigen challenge in guinea-pigs.
1. Repeated exposure to ovalbumin aerosol produced significant increases in epithelial eosinophils of airways of all sizes and produced increased pulmonary resistance (RL) to inhaled acetylcholine (ACh) in guinea-pigs. 2. Nedocromil sodium 10 mg ml-1, by nebulization prior to each ovalbumin (OA) challenge inhibited both the airway eosinophilia and hyperresponsiveness to ACh. 3. Nedocromil sodium pretreatment (10 mg ml-1 by nebulization) 10 min prior to OA completely inhibited the acute bronchoconstrictor response to OA. 4. Our findings suggest that nedocromil sodium inhibits airway hyperresponsiveness by inhibiting eosinophilic infiltration, or by simultaneously inhibiting mechanisms involved in both processes.
Schellenberg
R R
RR
UBC Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, Canada.
Ishida
K
K
Thomson
R J
RJ
D000109:Acetylcholine / Q000008:administration & dosage; D000280:Administration, Inhalation; D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D007958:Leukocyte Count / Q000187:drug effects; D017835:Nedocromil; D010047:Ovalbumin / Q000008:administration & dosage; D015363:Quinolones / Q000008:administration & dosage / Q000494:pharmacology*
D015363:Quinolones; D017835:Nedocromil; D010047:Ovalbumin; D000109:Acetylcholine