[The single administration of ethanol and the amplitude of the action potentials of the neocortical neurons in rats: extracellular studies].
On outbred rats the influence was studied of acute administration of moderate dozes of ethanol (150 mg--1.2 g/kg, intraperitoneally) on the motor cortex neurones. It was shown that ethanol in the range of these dozes led to a change of the amplitude of extracellularly recorded action potentials, which could be directed to an increase or decrease. In the used range minimum as well as maximum dozes in various animals might elicit contrary effects, i.e. no dependence was observed of the direction of reaction of the studied neurones on the administrated doze. Possible mechanisms are discussed which may be the basis of the change of the amplitude of extracellular action potentials. Conclusion is made that use of moderate dozes of ethanol is a useful condition for studies directed to a search of mechanisms of initial reaction to alcohol action.
Stashkevich
I S
IS
Maksimova
L N
LN
Sokolov
S S
SS
Gaziev
A K
AK
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology
D000431:Ethanol
Odnokratnoe vvedenie étanola i amplituda potentsialov deĭstviia neĭronov neokorteksa krys: ékstrakletochnye issledovaniia.