131I-rose bengal therapy in hepatoblastoma patients.
If conventional treatment modalities have failed in hepatoblastoma patients and no distant metastases can be demonstrated therapy with radionuclide agents can be considered. In 6 patients diagnostic technetium-99m (99mTc)-disofenin and two iodine-131 (131I)-rose bengal scans were made. 2 patients demonstrated specific uptake of disofenin. One of these had a positive scintigram with radiolabelled rose bengal. This patient was subsequently treated with 1.1 GBq 131I-rose bengal. No toxicity was observed. A clear decrease in the level of alpha-fetoprotein indicated a response and demonstrated that this radiopharmaceutical can be used for tumour targeted radiation therapy in selected patients with therapy resistant tumours.
de Kraker
J
J
Werkgroep Kindertumoren, Emma Kinderziekenhuis/het kinder AMC, Amsterdam, The Netherlands.
Hoefnagel
C A
CA
Voûte
P A
PA
D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D007098:Imino Acids; D007223:Infant; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008099:Liver / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012395:Rose Bengal / Q000627:therapeutic use*; D019785:Technetium Tc 99m Disofenin
D007098:Imino Acids; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D012395:Rose Bengal; D019785:Technetium Tc 99m Disofenin