HLA-Dr expression by tumor cells compared with survival in high grade astrocytomas.
Frozen samples from 78 high grade astrocytomas were reacted with a monoclonal antibody directed against HLA-Dr invariant chain. Survival data was obtained for all 78 cases. HLA-Dr was expressed by a proportion of tumor cells in 65/78 (83%). Comparison of the survival of positive and negative cases showed that the difference was not statistically significant (p = 0.4). The relevance of the finding is discussed in the context of the immunoreaction to brain tumors.
Rossi
M L
ML
Dept. of Neuropathology and Neurosurgery, Radcliffe Infirmary, Oxford, United Kingdom.
Jones
N R
NR
Karr
G F
GF
Esiri
M M
MM
Havas
L
L
Coakham
H B
HB
D000951:Antigens, Neoplasm / Q000032:analysis*; D005909:Glioblastoma / Q000276:immunology / Q000401:mortality*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D015996:Survival Rate
D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens