title: Pathological features of virus infections of the central nervous system (CNS) in the acquired immunodeficiency syndrome (AIDS).
abstract: Neurological disorders are a common cause of morbidity and mortality in the acquired immunodeficiency syndrome (AIDS). In this report we describe the neuropathological changes associated with both human immunodeficiency virus (HIV) infection and with the major opportunistic virus infections, cytomegalovirus (CMV), JC papovavirus (JCV) and herpes simplex virus (HSV) seen in AIDS. In addition "in situ" hybridization studies have been employed for the detection of virus genomic material in each case and the usefulness of this method in supporting the pathological diagnosis is demonstrated. Mechanisms whereby HIV infection results in leukoencephalopathy and the possible contributing roles of the three opportunistic virus infections are discussed.
authors.affiliation: Department of Infectious Disease, North Shore University Hospital, Manhasset, NY.
authors.forename: W W
authors.initials: WW
authors.lastname: Hall
authors.forename: P M
authors.initials: PM
authors.lastname: Farmer
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Furuta
authors.forename: K
authors.initials: K
authors.lastname: Nagashima
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology; D000328:Adult; D000368:Aged; D002490:Central Nervous System / Q000382:microbiology / Q000473:pathology; D002493:Central Nervous System Diseases / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000473:pathology; D004279:DNA, Viral / Q000235:genetics; D006561:Herpes Simplex / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D009693:Nucleic Acid Hybridization; D009894:Opportunistic Infections / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D027383:Papillomaviridae / Q000302:isolation & purification; D027382:Polyomaviridae; D018139:Simplexvirus / Q000302:isolation & purification; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology
chemical_list: D004279:DNA, Viral