title: Pituitary hyperplasia after goserelin (LHRH-analogue) therapy.
abstract: A 78-year-old male was treated with goserelin (Zoladex) for 16 months for metastasizing prostate carcinoma. This therapy is clinically equivalent to orchidectomy, as the application of the luteinizing hormone-releasing hormone (LHRH)-analogue Zoladex causes suppression of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by down-regulation of pituitary receptors. Consequently, testicular androgen production is inhibited and testosterone levels are decreased to castration levels. In the present case we found diffuse, partially nodular hyperplasia of growth hormone (GH) and adrenocorticotropin (ACTH) producing cells in the anterior pituitary gland at autopsy. As Zoladex reduces pituitary receptors for releasing hormones (RH), a globally increased hypothalamic secretion of RH might be responsible for the ACTH- and the GH-cell hyperplasia. We cannot exclude that Zoladex may cause not only adenomas in rat pituitary glands as reported previously, but also a (nodular) hyperplasia of the pituitary gland in man.
authors.affiliation: Institute of Pathology, University of Graz, School of Medicine, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Radner
authors.forename: K
authors.initials: K
authors.lastname: Pummer
authors.forename: S
authors.initials: S
authors.lastname: Lax
authors.forename: G
authors.initials: G
authors.lastname: Wandschneider
authors.forename: H
authors.initials: H
authors.lastname: Höfler
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis; D000368:Aged; D002064:Buserelin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017273:Goserelin; D013006:Growth Hormone / Q000096:biosynthesis; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D009362:Neoplasm Metastasis; D009919:Orchiectomy; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D017273:Goserelin; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D002064:Buserelin