title: Biotype as determinant of natural immunising effect of cholera.
abstract: To test the hypothesis that clinical Vibrio cholerae O1 infections protect against recurrent cholera, treated cholera episodes in a rural Bangladesh population of 188,153 people who were followed between 1985 and 1988 were analysed. Of the 2214 people with initial episodes of cholera, 7 had a second episode. The incidence of cholera was 61% lower in subjects who had had an earlier episode than in those without such an episode. Whereas initial episodes of classical cholera were associated with complete protection against subsequent cholera, initial episodes of El Tor cholera were associated with negligible protection.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
authors.forename: J D
authors.initials: JD
authors.lastname: Clemens
authors.forename: F
authors.initials: F
authors.lastname: van Loon
authors.forename: D A
authors.initials: DA
authors.lastname: Sack
authors.forename: M R
authors.initials: MR
authors.lastname: Rao
authors.forename: F
authors.initials: F
authors.lastname: Ahmed
authors.forename: J
authors.initials: J
authors.lastname: ChakrabortY
authors.forename: B A
authors.initials: BA
authors.lastname: Kay
authors.forename: M R
authors.initials: MR
authors.lastname: Khan
authors.forename: M D
authors.initials: MD
authors.lastname: Yunus
authors.forename: J R
authors.initials: JR
authors.lastname: Harris
mesh_terms: D000293:Adolescent; D000328:Adult; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000276:immunology*; D022121:Cholera Vaccines / Q000276:immunology; D005260:Female; D006801:Humans; D007110:Immunity, Active; D011159:Population Surveillance; D011446:Prospective Studies; D012008:Recurrence; D014734:Vibrio cholerae / Q000276:immunology*
chemical_list: D022121:Cholera Vaccines