[Pharmacokinetic study of adriamycin in the emulsion mixed with lipiodol-difference resulting from composition and methods of preparation, and behavior after mesenteric arterial injection in rat].
We experimentally investigated the pharmacokinetics of adriamycin (ADM) in a similar of transcatheter arterial chemoembolization therapy (TAE) of hepatocellular carcinoma using emulsion of lipiodol (Lp) mixed with ADM followed by gelatin sponge, and the difference resulting from composition and method of preparation of the emulsion as well as behavior after mesenteric arterial injection in rat. In in vitro study, the emulsion with iopamidol (iopamiron 300 : IP) was more stable than with amidotrizoic acid (60% Urografin : UG). The highest stability was found in the mixing ratio of Lp. IP and distilled water at 1 : 0.42 : 0.08. Frequent pumping also made the emulsion more stable. But in optimally composed emulsion, pumping 20 or 50 times made no difference in the stability during 30 min. which may be longer than the time from preparation to injection time of the emulsion in clinical application. After injection of the emulsion into the mesenteric artery which may simulate injection into the hepatic artery in hepatocellular carcinoma, the arterial blood flow was suspended. In the peripheral arteries the emulsion separated into two phases of Lp and ADM solution, forming striped pattern, and Lp embolization of the peripheral artery persisted for over 45 min. while ADM extravasated. These findings suggest that after Lp-TAE, Lp maintains an embolizing effect while ADM penetrates into the surrounding tumor tissue, and that this is an underlying mechanism for the anti-cancer effect of Lp-TAE.
Sakaguchi
H
H
Dept. of Radiology and Oncoradiology, Nara Medical University, Kashihara, Japan.
Uchida
H
H
Nishimura
Y
Y
Guo
Q Y
QY
Yoshimura
H
H
Ohishi
H
H
D000818:Animals; D003974:Diatrizoate Meglumine / Q000008:administration & dosage; D004317:Doxorubicin / Q000493:pharmacokinetics*; D004621:Embolization, Therapeutic / Q000379:methods / Q000592:standards*; D004655:Emulsions; D007269:Injections, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D007479:Iopamidol / Q000008:administration & dosage; D008638:Mesenteric Arteries / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013152:Splanchnic Circulation
D004655:Emulsions; D003974:Diatrizoate Meglumine; D007459:Iodized Oil; D004317:Doxorubicin; D007479:Iopamidol