The effect of subchronic poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats.
The intestinal transport of D-xylose was studied during subchronic poisoning of male Wistar rats with the oral administration of potassium nitrate and sodium nitrite. The metabolic parameters of small intestine mucosa were determined one hour after xylose administration, i.e., Na+/K(+)-ATPase, alkaline phosphatase, oxygen consumption, and lactic acid level. Nitrite reduced the absorption of xylose and decreased the activity of Na+/K(+)-ATPase and alkaline phosphatase. No effect of sodium nitrite was demonstrated on the aerobic metabolism of intestinal mucosa with an increased lactic acid level. Potassium nitrate did not effect the processes of intestinal absorption of xylose nor the metabolic parameters of small intestine mucosa.
Grudziński
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I
Department of Food Studies and Nutrition Physiology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Szymański
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A
D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D010101:Oxygen Consumption; D017680:Potassium Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012977:Sodium Nitrite / Q000633:toxicity*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014994:Xylose / Q000493:pharmacokinetics*
D009566:Nitrates; D017680:Potassium Compounds; D014994:Xylose; D000469:Alkaline Phosphatase; D000254:Sodium-Potassium-Exchanging ATPase; D012977:Sodium Nitrite; C023844:potassium nitrate