Altered cellular responsiveness during ageing.
The capacity of cells and organisms to respond to external stimuli and to maintain stability in order to survive decreases progressively during ageing. The mitogenic and stimulatory effects of growth factors, hormones and other agents are reduced significantly during cellular ageing. The sensitivity of ageing cells to toxic agents including antibiotics, phorbol esters, radiations and heat shock increases. This failure of homeostasis during cellular ageing does not appear to be due to any quantitative and qualitative defects in the receptor systems. Instead, metabolic defects in the pathways of macromolecular synthesis may be the basis of altered cellular responsiveness during ageing.
Rattan
S I
SI
Department of Chemistry, Aarhus University, Denmark.
Derventzi
A
A
D000375:Aging / Q000502:physiology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002455:Cell Division; D016922:Cellular Senescence / Q000502:physiology*; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D006133:Growth Substances / Q000502:physiology; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D010703:Phorbol Esters / Q000494:pharmacology; D014176:Protein Biosynthesis; D011956:Receptors, Cell Surface / Q000502:physiology
D000900:Anti-Bacterial Agents; D006133:Growth Substances; D006360:Heat-Shock Proteins; D010703:Phorbol Esters; D011956:Receptors, Cell Surface