The interaction of block copolymers of ethylene oxide and propylene oxide and their polymer-protein conjugates with lipids.
The interaction of block copolymers of ethylene oxide and propylene oxide with lipid structures-monolamellar and multilamellar vesicles from egg yolk lecithin and dipalmitoylphosphatidylcholine-was studied by differential scanning calorimetry, light scattering, and electron spin resonance. Copolymers with different ratios of hydrophilic: hydrophobic portions, numbers of polymers, and arrangements or positions of the blocks, as well as conjugates of polymers with proteins, were used. Peculiarities in the macromolecular structure of the copolymers influence the character of their interactions with lipids. The effects of copolymers which become incorporated into the lipid bilayer are compared with that of polyethyleneglycol which influences lipid structure in an indirect manner.
Topchieva
I N
IN
School of Chemistry, Moscow State University.
Volodin
V V
VV
Tyukavin YuA
Osipova
S V
SV
Kulakov
V N
VN
Banatskaya
M I
MI
D004578:Electron Spin Resonance Spectroscopy; D004852:Epoxy Compounds / Q000737:chemistry*; D005027:Ethylene Oxide / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D046911:Macromolecular Substances; D011092:Polyethylene Glycols / Q000494:pharmacology; D011108:Polymers; D011506:Proteins / Q000737:chemistry*; D013696:Temperature
D004852:Epoxy Compounds; D008051:Lipid Bilayers; D008055:Lipids; D008081:Liposomes; D046911:Macromolecular Substances; D011108:Polymers; D011506:Proteins; D011092:Polyethylene Glycols; D005027:Ethylene Oxide; C009068:propylene oxide