[Heterochromatin as a factor influencing X-chromosome inactivation in hybrids of the common vole (Microtinae, Rodentia)].
Expression of X-linked genes for G6PD and alpha-GAL was studied in female interspecific hybrids of Microtus. The G6PD and alpha-GAL isozymes of Microtus arvalis were found to predominate in all cases when a species carrying a heterochromatin block on the X-chromosome served as one partner of hybridization and M. arvalis containing no heterochromatin block served as another. The proportions of G6PD and alpha-GAL parental forms were approx. equal in hybrid females when both species participating in hybridization contained heterochromatin blocks on X-chromosomes. Cytological analysis for revealing active and nonactive X-chromosomes on metaphase spreads of hybrid females supports the biochemical data. Non-random inactivation of X-chromosomes carrying the heterochromatin blocks in the interspecific hybrids with M. arvalis and a random one, when both parents contain heterochromatin blocks on the X-chromosomes are supposed to be the cause for the phenomenon observed. The study provided data supporting our previous hypothesis that heterochromatin affects the X-chromosome inactivation process in interspecific hybrid voles.
Zakiian
S M
SM
Nesterova
T B
TB
Cheriaukene
O V
OV
Bochkarev
M N
MN
D000818:Animals; D003411:Arvicolinae / Q000235:genetics*; D004303:Dosage Compensation, Genetic; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006570:Heterochromatin / Q000502:physiology*; D006824:Hybridization, Genetic / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics; D008677:Metaphase / Q000502:physiology; D000519:alpha-Galactosidase / Q000235:genetics
D006570:Heterochromatin; D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase; D000519:alpha-Galactosidase
Geterokhromatin kak faktor, vliiaiushchiĭ na inaktivatsiiu X-khromosomy u gibridov obyknovennoĭ polevki (Microtidae, Rodentia).