[Effects of svate on platelet morphology and function in patients with coronary heart disease and hypertension].
The effects of svate on platelet morphology and aggregation were studied and compare with Radix Salviae Miltiorrhizae. The results showed that svate remarkably inhibited platelet aggregation in patients with coronary heart disease and hypertension. Svate could increase plasma 6-keto-PGF1 alpha and decrease plasma TXB2. After treatment with svate, levels of platelet cAMP was increased. Svate enhanced platelet 5-HT and reduced plasma 5-HT. Electron microscopic study showed that the percentage of discoid and dendritic platelets were increased, while those of spread and aggregate platelets were decreased following svate therapy. It was found that svate is superior to Radix Salviae Miltiorrhizae in inhibition of platelet function. The results indicate that svate inhibits platelet aggregation and release through increasing prostacyclin generation in the vascular wall, raising platelet cAMP and inhibition of TXA2 production.
Li
L
L
Affiliated Hospital, Jiamusi Medical College, Heilongjiang.
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood / Q000628:therapy*; D000242:Cyclic AMP / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004546:Elapid Venoms / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010618:Phenanthrolines / Q000627:therapeutic use; D010936:Plant Extracts; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D027561:Salvia miltiorrhiza; D012701:Serotonin / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004546:Elapid Venoms; D010618:Phenanthrolines; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C028972:dan-shen root extract; D012701:Serotonin; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D000242:Cyclic AMP