[Sensitivity of Hemophilus strains to fluoroquinolones].
The sensitivity of haemophilus strains isolated from patients freshly were tested by newly produced fluorokinolones with broader antimicrobial activity and excellent pharmacokinetic features. We found a high sensitivity of all haemophilus strains tested by ofloxacin with Resistest method. The minimal inhibitory concentrations in Levinthal bouillon medium ranged between 0,015-0,03 micrograms/ml and the exerted a bactericidal effect. Since these concentrations are only a small portion of the blood and tissue levels of the ofloxacin, therefore the fluorokinolones proved to be effective antibacterial drugs in the therapy of the haemophilus infections.
Csukás
Z
Z
Semmelweis Orvostudományi Egyetem, Budapest.
Sztankov
L
L
Cserba
I
I
D004352:Drug Resistance, Microbial; D006190:Haemophilus / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D015242:Ofloxacin / Q000494:pharmacology*; D015366:Pefloxacin; D015363:Quinolones / Q000494:pharmacology*
D015363:Quinolones; D015366:Pefloxacin; D015242:Ofloxacin
Haemophilus törzsek fluorokinolonok iránti érzékenysége.