title: Virus-associated haemophagocytic syndrome with Epstein-Barr virus infection.
abstract: The clinical and histological findings of a 10-year-old girl with virus-associated haemophagocytic syndrome are presented. The serum levels of Epstein-Barr viral antigens were elevated. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in bone marrow and lymph node specimens. Histologically, haemophagocytic histiocytes were present in bone marrow, and areas of non-suppurative necrosis were present in lymph nodes, where silver grain deposition of the EBV genome was demonstrated by in situ hybridization.
authors.affiliation: Department of Pathology, School of Medicine, Fukuoka University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: F
authors.initials: F
authors.lastname: Eguchi
authors.forename: S
authors.initials: S
authors.lastname: Kobari
authors.forename: H
authors.initials: H
authors.lastname: Tasaka
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D005293:Ferritins / Q000097:blood; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006644:Histiocytes / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008969:Molecular Sequence Data; D009336:Necrosis; D009693:Nucleic Acid Hybridization; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology / Q000473:pathology*
chemical_list: D000956:Antigens, Viral; D005293:Ferritins