Murine cytomegalovirus myocarditis.
Murine cytomegalovirus infects a variety of organs after inoculation into adult male mice. We have established a model of myocarditis in which focal lesions from adjacent to virus-infected endothelial cells. The development of the myocarditis is mediated by CD4+ helper T cells. The lesions fail to develop when these cells are eliminated from the animal by administration of a specific monoclonal antibody. Alternatively, repletion of thymectomized, irradiated and bone-marrow reconstituted animals with CD4+ cells results in myocarditis. The evidence, although incomplete, suggests that a delayed hypersensitivity response is the pathogenetic mechanism involved.
Craighead
J E
JE
Department of Pathology, University of Vermont College of Medicine, Burlington 05405.
Huber
S A
SA
Martin
W B
WB
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000276:immunology*; D004195:Disease Models, Animal; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000276:immunology / Q000382:microbiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens