title: Five-year survival after hyperfractionated radiation therapy for non-small-cell carcinoma of the lung (NSCCL): results of RTOG protocol 81-08.
abstract: RTOG Protocol 81-08, a feasibility study of hyperfractionated radiation therapy (HFX) with 1.2 Gy twice daily separated by 4-6 hours for non-small-cell cancer of the lung (NSCCL), was completed in 1983. Encouraging short-term results in a recently closed trial of HFX for NSCCL (RTOG 83-11) led to assessment of long-term outcome in the earlier trial. Of 120 evaluable patients who were assigned to total doses from 50.4 Gy to 74.4 Gy, all 5 of the 5-year survivors came from the 79 patients assigned to receive 69.6 Gy. The 5-year survival rates for the 79 patients were 14.3 +/- 9.4% for clinical RTOG Stage II, 5.9 +/- 4.0% for Stage III, and 3.2 +/- 3.2% for Stage IV. Combined Stage II and III 5-year survival rates were 8.3 +/- 4.0% for HFX 69.6 Gy compared to 5.6 +/- 1.5% for standard once-a-day irradiation in concurrent RTOG trials.
authors.affiliation: University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: J D
authors.initials: JD
authors.lastname: Cox
authors.forename: T F
authors.initials: TF
authors.lastname: Pajak
authors.forename: A
authors.initials: A
authors.lastname: Herskovic
authors.forename: R
authors.initials: R
authors.lastname: Urtasun
authors.forename: W J
authors.initials: WJ
authors.lastname: Podolsky
authors.forename: H G
authors.initials: HG
authors.lastname: Seydel
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D002985:Clinical Protocols / Q000592:standards*; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011878:Radiotherapy / Q000379:methods* / Q000592:standards; D011879:Radiotherapy Dosage; D015996:Survival Rate