Supernatant of human umbilical vein endothelial cell culture can favour in vivo neutropoiesis.
Umbilical vein endothelial cells are known to be able to produce interleukins and colony stimulating factors. In the present work supernatant of human umbilical vein endothelial cell culture have been administered to neoplastic patients treated with chemotherapy to reduce the iatrogenic inhibition of hemopoiesis. While no undesired effect could be observed, neutrophil count was favourably influenced by endothelial cell supernatant administration. Such data can be considered useful in order to reduce collateral effect of antineoplastic therapy.
Ghezzo
F
F
Department of Clinical and Biological Sciences, University of Turin, Italy.
Garbarino
G
G
Osella
D
D
Romano
S
S
Dolcetti
A
A
Pegoraro
L
L
Emanuelli
G
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002330:Carmustine / Q000008:administration & dosage / Q000009:adverse effects; D002478:Cells, Cultured; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D017077:Culture Media, Conditioned / Q000737:chemistry / Q000494:pharmacology*; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D004730:Endothelium, Vascular / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D006410:Hematopoiesis / Q000187:drug effects*; D016298:Hematopoietic Cell Growth Factors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced / Q000628:therapy*; D009504:Neutrophils; D013713:Teniposide / Q000008:administration & dosage / Q000009:adverse effects; D014471:Umbilical Veins / Q000166:cytology*
D017077:Culture Media, Conditioned; D016298:Hematopoietic Cell Growth Factors; D007155:Immunologic Factors; D003561:Cytarabine; D013713:Teniposide; D002945:Cisplatin; D002330:Carmustine