Alterations in opiate receptor binding in MPTP-induced hemiparkinsonian monkeys.
Quantitative autoradiography was used to study [3H]naloxone binding in the striatum of normal monkeys and monkeys made hemiparkinsonian by the unilateral infusion of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The density of [3H]naloxone binding sites was significantly higher in the caudate and putamen on the MPTP-treated side of hemiparkinsonian monkeys, as compared with binding on the untreated side and in the striatum of normal monkeys. A more extensive patchy distribution of binding sites was evident throughout the striatum on the MPTP-treated side than seen in the striatum of the untreated side or in normal striatum.
Porrino
L J
LJ
Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892.
Viola
J J
JJ
Crane
A M
AM
Pontieri
F E
FE
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D005260:Female; D007839:Functional Laterality; D008253:Macaca mulatta; D008297:Male; D009270:Naloxone / Q000378:metabolism*; D010302:Parkinson Disease, Secondary / Q000378:metabolism*; D011957:Receptors, Opioid / Q000378:metabolism
D011957:Receptors, Opioid; D009270:Naloxone; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine