title: Eukaryotic DNA repair: glimpses through the yeast Saccharomyces cerevisiae.
abstract: Eukaryotic cells are able to mount several genetically complex cellular responses to DNA damage. The yeast Saccharomyces cerevisiae is a genetically well characterized organism that is also amenable to molecular and biochemical studies. Hence, this organism has provided a useful and informative model for dissecting the biochemistry and molecular biology of DNA repair in eukaryotes.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235.
authors.forename: E C
authors.initials: EC
authors.lastname: Friedberg
mesh_terms: D000818:Animals; D002453:Cell Cycle; D004249:DNA Damage; D004265:DNA Helicases / Q000235:genetics / Q000502:physiology; D004260:DNA Repair; D004271:DNA, Fungal / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D004790:Enzyme Induction; D005057:Eukaryotic Cells / Q000502:physiology*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal; D006801:Humans; D008322:Mammals / Q000235:genetics / Q000502:physiology; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D014983:Xeroderma Pigmentosum / Q000235:genetics
chemical_list: D004271:DNA, Fungal; D005656:Fungal Proteins; D004265:DNA Helicases