Enhanced neutrophil functions in a patient with colony-stimulating activity-producing lung cancer.
We studied neutrophil functions in a patient with colony-stimulating activity (CSA)-producing lung cancer. A 59-year-old man had an abnormal chest X-ray and leucocytosis, predominantly with neutrophils. Pneumonectomy was performed, and the histological diagnosis of the tumour was large-cell carcinoma of the lung. The tumour induced marked granulocytosis in tumour-transplanted nude mice, and the conditioned media of the tumour contained very strong human-active CSA. Superoxide release and membrane depolarization in neutrophils stimulated by the chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine, were markedly enhanced in the patient. These findings suggest that CSA produced by the tumour primed neutrophil functions in vivo in the patient.
Ohsaka
A
A
Department of Transfusion Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Kitagawa
S
S
Ikeda
K
K
Motoyoshi
K
K
Miura
Y
Y
Kira
S
S
Saito
M
M
D000818:Animals; D000001:Calcimycin; D002289:Carcinoma, Non-Small-Cell Lung / Q000503:physiopathology*; D003115:Colony-Stimulating Factors / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology*; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009368:Neoplasm Transplantation; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D013481:Superoxides / Q000378:metabolism
D003115:Colony-Stimulating Factors; D013481:Superoxides; D000001:Calcimycin; D009240:N-Formylmethionine Leucyl-Phenylalanine