Laterality and 3H-imipramine binding: studies in the frontal cortex of normal controls and suicide victims.
Serotonin [5-hydroxytryptamine (5-HT)]-sensitive imipramine binding (IB) was determined in the left and right hemisphere of frontal cortex of suicide victims and nonpsychiatric controls who died due to myocardial infarction or accident. The Kd (an inverse measure of affinity of 3H-imipramine to its binding sites) was significantly higher in left hemisphere than right hemisphere in normal controls. There were no differences in Bmax and Kd or Bmax between left hemisphere and right hemisphere in normals and suicides, respectively. These results do not support the finding of hemispheric asymmetry of 5-HT uptake as measured by IB (Bmax) in postmortem tissue from controls and suicide victims.
Arora
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RC
Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
Meltzer
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HY
D002352:Carrier Proteins; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D011869:Radioligand Assay; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D013405:Suicide / Q000523:psychology*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; D011985:Receptors, Serotonin; C027775:imipramine receptor; D007099:Imipramine