title: Effects of partial inbreeding on fixation rates and variation of mutant genes.
abstract: Diffusion methods were used to investigate the fixation probability, average time until fixation and extinction, and cumulative heterozygosity and genetic variance for single mutant genes in finite populations with partial inbreeding. The critical parameters in the approximation are the coefficient of inbreeding due to nonrandom mating (F) and the effective population size (Ne), which also depends on F and the variance of family size. For large Ns, the fixation probability (u) is u = 2(Ne/N)s (F + h - Fh), where N is the population census, s is the coefficient of selection of the mutant homozygote and h is the coefficient of dominance. For Poisson family size (independent Poisson distributions of selfed and nonselfed offspring with partial selfing, and independent Poisson distributions of male and female numbers with partial sib mating), Ne = N/(1 + F), and the time until fixation is approximately equal to Ne/N times the time to fixation with random mating, but this relation does not hold, however, for other distributions of family size. The cumulative nonadditive variance until fixation or loss for dominant genes is reduced with increasing F while for recessive genes it is increased with intermediate values of F. The average time until extinction of deleterious mutations is reduced by increasing F. This reduction, when expressed as a proportion, is approximately independent of the initial gene frequency as well as the selective disadvantage if this is large.
authors.affiliation: Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland.
authors.forename: A
authors.initials: A
authors.lastname: Caballero
authors.forename: W G
authors.initials: WG
authors.lastname: Hill
mesh_terms: D000818:Animals; D003241:Consanguinity; D005191:Family Characteristics; D014644:Genetic Variation; D006801:Humans; D007178:Inbreeding; D008098:Litter Size; D008957:Models, Genetic; D009154:Mutation