20 alpha-hydroxysteroid dehydrogenase expression in a murine virus-induced myeloproliferative syndrome.
The myeloproliferative sarcoma virus (MPSV) infection in DBA/2 mice leads to important quantitative and qualitative changes in their hemopoiesis. These findings suggest a disturbance in the production and action of a certain hemopoietic factor similar to IL3. Here, we show that the level of the 20 alpha-hydroxysteroid dehydrogenase (20 alpha-SDH) expression, which can be induced by IL3, is dramatically increased in spleen and thymus of MPSV-infected mice. Our results suggest that quantification of 20 alpha-SDH activity can be used to indicate abnormal production of a growth factor similar to IL3 in hemopoietic system diseases.
Marcovistz
R
R
INSERM U 268, Hôpital Paul-Brousse, Villejuif, France.
Le Bousse-Kerdiles
M C
MC
Maillere
B
B
Smadja-Joffe
F
F
Poirrier
V
V
Jasmin
C
C
D015089:20-Hydroxysteroid Dehydrogenases / Q000096:biosynthesis*; D000818:Animals; D004790:Enzyme Induction; D007377:Interleukin-3 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D009196:Myeloproliferative Disorders / Q000201:enzymology* / Q000382:microbiology; D012192:Retroviridae Infections; D009053:Sarcoma Viruses, Murine; D012513:Sarcoma, Experimental / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D013577:Syndrome; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism
D007377:Interleukin-3; D015089:20-Hydroxysteroid Dehydrogenases