title: The effect of maternal supplementation with linoleic and gamma-linolenic acids on the fat composition and content of human milk: a placebo-controlled trial.
abstract: Total fat content and therefore total energy content and the content of essential fatty acids (EFAs) in milk are known to decline with prolonged breast feeding. In a placebo-controlled study a variety of evening primrose oil (Efamol) rich in linoleic and gamma-linolenic acids, or a matching placebo were given to 39 women for a period of 8 months starting between the 2nd and 6th months of lactation. Total fat and EFA contents of the milk declined in the placebo group but rose in the primrose oil supplemented group. A surprisingly high proportion of the supplemented dietary fatty acids could be accounted for by appearance in the milk. The milk composition can be readily manipulated by changing the fatty acid composition of the maternal diet.
authors.affiliation: Department of Child Health, St George's Hospital Medical School, London, England.
authors.forename: A
authors.initials: A
authors.lastname: Cant
authors.forename: J
authors.initials: J
authors.lastname: Shay
authors.forename: D F
authors.initials: DF
authors.lastname: Horrobin
mesh_terms: D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis; D005228:Fatty Acids, Essential / Q000032:analysis; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008042:Linolenic Acids / Q000494:pharmacology*; D008895:Milk, Human / Q000737:chemistry*; D017965:gamma-Linolenic Acid
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid