title: A study on house fire victims: age, carboxyhemoglobin, hydrogen cyanide and hemolysis.
abstract: Correlation among age, concentrations of carboxyhemoglobin and hydrogen cyanide, oxygen density and hemolysis were studied in 120 house fire victims. Victims aged over 60 years comprised approximately 50% of the pooled subjects. Blood samples were mainly collected from the left ventricle, but sometimes from both the right and left ventricles. The concentration of carboxyhemoglobin ranged from 1-95%, of which 71 persons (59.7%) died with carboxyhemoglobin concentrations below 60%. Carboxyhemoglobin concentrations below 10% were found in 9 persons (7.5%). Most of these cases involved the elderly persons. In this paper, we report on the death of elderly victims as a result of low carboxyhemoglobin concentrations. A significant correlation of blood carboxyhemoglobin concentrations existed between the right and left ventricles. The concentration of carboxyhemoglobin in the left ventricle was significantly higher than that in the right. Two out of 31 victims whose hydrogen cyanide concentrations were determined, succumbed to hydrogen cyanide poisoning, having a high concentration of hydrogen cyanide and a low concentration of carboxyhemoglobin. On analysis, oxygen density was found to be low in 13 persons. A negative correlation was shown between carboxyhemoglobin concentration and hemolysis. Inasmuch as hemolysis may indicate the extent of heat dissociation, hemolysis should provide an index of carbon monoxide dissociation from carboxyhemoglobin. In the present study of victims, possible causes of death i.e., carbon monoxide gas poisoning, hydrogen cyanide poisoning, oxygen deprivation, burning, shock due to burns and others were estimated. The survival time for elderly victims was considered to be short.
authors.affiliation: Department of Legal Medicine, Kansai Medical University, Moriguchi, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: J
authors.initials: J
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Watabiki
authors.forename: Y
authors.initials: Y
authors.lastname: Tatsuno
authors.forename: N
authors.initials: N
authors.lastname: Ishida
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000175:diagnosis*; D002263:Carboxyhemoglobin / Q000032:analysis*; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D005260:Female; D005390:Fires; D006461:Hemolysis; D006801:Humans; D006856:Hydrogen Cyanide / Q000097:blood* / Q000506:poisoning; D008297:Male; D051379:Mice; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011041:Poisoning / Q000097:blood / Q000175:diagnosis
chemical_list: D006856:Hydrogen Cyanide; D002263:Carboxyhemoglobin; D010100:Oxygen