title: The impact of concomitant viral pathogens on the course of Pneumocystis carinii pneumonia.
abstract: A large retrospective study was conducted to evaluate the impact of culturing cytomegalovirus from the respiratory secretions of AIDS patients with Pneumocystis carinii pneumonia. Pneumocystis carinii was found in 220 (67%) of 327 episodes and cytomegalovirus was found in 106 (48%) of the P. carinii-positive patients. Cytomegalovirus-positive and -negative patients were similar at baseline and had a similar number of hospital days, but had a lower incidence of early deterioration in oxygenation, fewer intensive-care days, were less frequently intubated, and had a higher 30-day survival. The better short-term outcome of cytomegalovirus positive patients observed in this study may relate to the immunosuppressive effects of cytomegalovirus.
authors.affiliation: Department of Medicine, University of California San Diego 92103-8208.
authors.forename: S A
authors.initials: SA
authors.lastname: Bozzette
authors.forename: J
authors.initials: J
authors.lastname: Arcia
authors.forename: A E
authors.initials: AE
authors.lastname: Bartok
authors.forename: L M
authors.initials: LM
authors.lastname: McGlynn
authors.forename: J A
authors.initials: JA
authors.lastname: McCutchan
authors.forename: D D
authors.initials: DD
authors.lastname: Richman
authors.forename: R
authors.initials: R
authors.lastname: Spragg
authors.forename: S A
authors.initials: SA
authors.lastname: Spector
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000150:complications*; D011020:Pneumonia, Pneumocystis / Q000150:complications* / Q000503:physiopathology; D012189:Retrospective Studies