title: Asymmetry in periodontal bone loss of gnotobiotic Sprague-Dawley rats.
abstract: In five consecutive experiments involving 78 gnotobiotic rats, significant bone loss was seen in the maxillae of those mono-infected with strains of Porphyromonas gingivalis. No significant bone loss was seen in the mandibles, and when data from both jaws were combined, the significant loss in the maxillae was occasionally concealed. It is recommended, therefore, that the levels of maxillary and mandibular bone in rats be analysed separately. A possible lateral bias of periodontal bone level was investigated in the same rats. In a highly significant number of cases the right-hand side was more severely affected than the left. This asymmetry was found in both germ-free and infected rats, and consequently could not be ascribed to P. gingivalis infection. Asymmetry of bone loss may contribute to the total random variation in bone level in rats and should be accounted for in future studies of experimental periodontitis in this model.
authors.affiliation: Institute of Periodontology, Royal Dental College, Copenhagen, Denmark.
authors.forename: B
authors.initials: B
authors.lastname: Klausen
authors.forename: C
authors.initials: C
authors.lastname: Sfintescu
authors.forename: R T
authors.initials: RT
authors.lastname: Evans
mesh_terms: D016301:Alveolar Bone Loss / Q000453:epidemiology / Q000209:etiology / Q000473:pathology*; D000704:Analysis of Variance; D000818:Animals; D001442:Bacteroides Infections / Q000150:complications*; D015982:Bias; D002985:Clinical Protocols / Q000592:standards; D005856:Germ-Free Life; D005882:Gingival Diseases / Q000150:complications*; D016966:Porphyromonas gingivalis; D051381:Rats; D011919:Rats, Inbred Strains; D014894:Weights and Measures / Q000592:standards*