Role of serotonin in hypothalamo pituitary adrenal axis escape from dexamethasone suppression.
1. The authors investigated the role of serotonin in the hypothalamo pituitary adrenal escape from depression. 2. Maximal dose of fenfluramine was administered to normal individuals pretreated with dexamethasone. 3. Fenfluramine had only a minimal and inconsistent effect on the hypothalamo pituitary adrenal axis in the presence of dexamethasone.
Krishnan
K R
KR
Department of Psychiatry, Duke University Medical Center, Durham, NC.
Ritchie
J C
JC
Manepalli
A N
AN
Wilson
W H
WH
Saunders
W B
WB
Venkataraman
S S
SS
Carroll
B J
BJ
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003907:Dexamethasone; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D012016:Reference Values; D012701:Serotonin / Q000502:physiology*
D005277:Fenfluramine; D012701:Serotonin; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone