Inhibitory effects of quinolones on murine hematopoietic progenitor cells and eukaryotic topoisomerase II.
The in vitro inhibitory effects of 12 quinolones, including clinically available compounds such as nalidixic acid, ofloxacin and enoxacin, on the murine hematopoietic progenitor cells and topoisomerase II of fetal calf thymus were compared. The quinolones tested inhibited the proliferation of the murine cells in a dose-dependent manner, and the cytotoxicity of quinolones correlated well (r = 0.910) with their inhibitory potency against the topoisomerase II.
Akahane
K
K
Research Institute, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
Hoshino
K
K
Sato
K
K
Kimura
Y
Y
Une
T
T
Osada
Y
Y
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005057:Eukaryotic Cells / Q000201:enzymology; D005260:Female; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D008264:Macrophages / Q000166:cytology; D051379:Mice; D059005:Topoisomerase II Inhibitors
D042462:4-Quinolones; D000890:Anti-Infective Agents; D059005:Topoisomerase II Inhibitors