Interleukin 4 promotes expression of mast cell ICAM-1 antigen.
Cell recognition molecules play a crucial role in the regulation of immune cells. We recently found that mast cells (MCs) express leukocyte recognition molecules, including ICAM-1 antigen, a natural ligand of LFA-1. We here report that interleukin 4 (IL-4), a pleiotropic cytokine and mast cell differentiation factor, selectively promotes expression of surface ICAM-1 antigen and ICAM-1 mRNA in human MCs. IL-4 also up-regulates ICAM-1 antigen in cells of monocyte/macrophage lineage but has no effect on ICAM-1 antigen expressed on basophils, fibroblasts, or lymphocytes. The increase in expression of mast cell/macrophage ICAM-1 antigen induced by IL-4 may contribute to the accumulation of leukocytes and facilitate cell-contact-dependent regulation of immune cells in inflamed tissues.
Valent
P
P
First Medical Department, University of Vienna, Austria.
Bevec
D
D
Maurer
D
D
Besemer
J
J
Di Padova
F
F
Butterfield
J H
JH
Speiser
W
W
Majdic
O
O
Lechner
K
K
Bettelheim
P
P
D015703:Antigens, CD / Q000235:genetics* / Q000378:metabolism; D015152:Blotting, Northern; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D005434:Flow Cytometry; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1; D015847:Interleukin-4 / Q000494:pharmacology*; D007946:Leukemia, Mast-Cell; D008407:Mast Cells / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D019948:Receptors, Interleukin-4; D011975:Receptors, Mitogen / Q000378:metabolism; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D012333:RNA, Messenger; D019948:Receptors, Interleukin-4; D011975:Receptors, Mitogen; D018799:Intercellular Adhesion Molecule-1; D015847:Interleukin-4