Histamine H2-receptor in atrium: signal transduction and response.
We have examined the signal transduction for H2-receptor mediated positive chronotropic response of guinea-pig right atrium. Our results indicate that phospholipid methylation is rapidly induced by histamine acting on H2-receptor in guinea-pig right atrium and therefore plays a predominant role in the signal transfer of H2-receptor-mediated cyclic AMP generation to exert positive chronotropic effect of atrium, as well as GTP-binding protein activation.
Ozawa
K
K
Department of Pharmacology, Hiroshima University School of Medicine, Japan.
Fujishima
Y
Y
Segawa
T
T
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis; D019204:GTP-Binding Proteins / Q000502:physiology; D006160:Guanosine Triphosphate / Q000494:pharmacology; D006168:Guinea Pigs; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006339:Heart Rate / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006710:Homocysteine / Q000494:pharmacology; D008745:Methylation; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011970:Receptors, Histamine H2 / Q000378:metabolism*; D015398:Signal Transduction; D013268:Stimulation, Chemical
D010743:Phospholipids; D011970:Receptors, Histamine H2; D006710:Homocysteine; D006632:Histamine; D006160:Guanosine Triphosphate; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases