[The role of activation of lipid peroxidation of the tissues in response of the body to nociceptive stimuli].
Taking into consideration that activation of free radical processes is an indispensable consequence of any extreme action on man and animals and that lipid peroxidation (LPO) metabolites may play a role of original "primary mediators of stress", an attempt was made to define LPO participation in body response to nociceptive stimuli. Investigations carried out in patients belonging to different nosological groups, differing in the intensity of pain, established the presence of a direct relationship between the potency of painful action and LPO activation. LPO activation was also observed in experiments on animals exposed to painful tourniquetting of the limbs. The data obtained allowed a conclusion about possible participation of free radical lipid peroxidation processes in the formation of nociception. This may be confirmed by the circumstance that reflexotherapy determined remarkable LPO activation together with removal of the painful syndrome.
Sutkovoĭ
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DA
D000818:Animals; D004195:Disease Models, Animal; D005609:Free Radicals; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D009443:Neuritis / Q000150:complications*; D010007:Osteochondritis / Q000150:complications*; D010146:Pain / Q000209:etiology / Q000378:metabolism / Q000523:psychology*; D010147:Pain Measurement; D051381:Rats; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000209:etiology / Q000378:metabolism*; D000159:Vestibulocochlear Nerve
D005609:Free Radicals
Rol' aktivatsii perekisnogo okisleniia lipidov tkaneĭ v reaktsii organizma na notsitseptivnye stimuly.