title: [Seroprevalence of antibodies to human herpesvirus 6 (exanthema subitum; critical 3-day fever-exanthema in young children) in the population of Northern Germany].
abstract: We tested 989 sera of all age groups (patients and blood donors) from north eastern Germany (West Pomerania and Mecklenburg) and found 820 cases (82.9%) of specific human herpes virus type 6 (HHV 6) antibodies (IgG) gy indirect immunofluorescent assay. The seroprevalence rose to 83.6% when the 7 HHV 6-IgM positive results (0.7%) were included; moreover a further 23 sera (2.3%) showed specific HHV 6 antibodies of both classes (IgM and IgG). The antibody prevalence was constantly high at 90% from the age of 8 months up to the 71-80 years group, and it only decreased in the age group over 80. 93.2% of the newborn infants showed HHV 6-IgG antibodies (of maternal origin) in the cord blood; this prevalence is identical with that for females of reproductive age (92.7% in the 3rd decade, 93.7% in the 4th decade). No sex differences in seroprevalence were observed. The main immunization occurs in the first year of life but infection with HHV 6 at a later age is also well documented. We found the lowest seroprevalence in the 3rd and 4th postnatal months (when maternal immunity had disappeared); later the seroprevalence of specific antibodies rose very rapidly and by the 8th month the rate was the same as for the adult group. The theoretical possibility of prenatal infection due to HHV 6 exists, but the real risk of a first infection during pregnancy is very low, because only 7-8% are susceptible in this group.
authors.affiliation: Klinik für Kindermedizin, Ernst-Moritz-Arndt-Universität Greifswald.
authors.forename: S
authors.initials: S
authors.lastname: Wiersbitzky
authors.forename: J
authors.initials: J
authors.lastname: Eberle
authors.forename: R
authors.initials: R
authors.lastname: Bruns
authors.forename: H
authors.initials: H
authors.lastname: Weidemeier
authors.forename: S
authors.initials: S
authors.lastname: Bittner
authors.forename: U
authors.initials: U
authors.lastname: Dorn
authors.forename: G
authors.initials: G
authors.lastname: Frick
authors.forename: E
authors.initials: E
authors.lastname: Abel
authors.forename: L
authors.initials: L
authors.lastname: Ladstätter
authors.forename: F
authors.initials: F
authors.lastname: Deinhardt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005077:Exanthema Subitum / Q000453:epidemiology / Q000276:immunology*; D005260:Female; D005858:Germany / Q000453:epidemiology; D015654:Herpesvirus 6, Human / Q000276:immunology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male
chemical_list: D000914:Antibodies, Viral
vernacular_title: Seroprävalenz von Antikörpern gegen das humane Herpesvirus 6 (HHV6) (Exanthema subitum; kritisches Dreitagefieber-Exanthem der Kleinkinder) in der Bevölkerung Norddeutschlands.