Inhibition of fertility in the male mouse by combined androgen-antiandrogen therapy.
Testosterone enanthate (TE) and oestradiol valerate (EV) in varying dose combinations were subcutaneously injected every alternate day for 10 or 20 days to adult male mouse of proven fertility. Such therapy resulted in suppression of fertility without affecting libido. The main possible cause of fertility inhibition appears to be testicular dysfunction as evidenced by histology and biochemistry of the reproductive organs.
Jacob
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D
Department of Zoology, University of Rajasthan, Jaipur, India.
Narula
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A
D000818:Animals; D002784:Cholesterol / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004966:Estrogens, Conjugated (USP) / Q000494:pharmacology*; D005298:Fertility / Q000187:drug effects*; D006003:Glycogen / Q000032:analysis; D008297:Male; D051379:Mice; D019158:N-Acetylneuraminic Acid; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D012794:Sialic Acids / Q000032:analysis; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000737:chemistry / Q000187:drug effects / Q000502:physiology; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology
D004338:Drug Combinations; D004966:Estrogens, Conjugated (USP); D012794:Sialic Acids; D013739:Testosterone; D004958:Estradiol; C004648:testosterone enanthate; D006003:Glycogen; D002784:Cholesterol; D019158:N-Acetylneuraminic Acid