Variable suppression of feline bone marrow fibroblast colony-forming units by two isolates of feline leukemia virus.
Bone marrow fibroblast colony-forming units (CFU-F) were evaluated in cats experimentally infected with different, isolates of FeLV. Cats infected with the Kawakami-Theilen isolate of FeLV (FeLV-KT) had progressive decrease in the number of CFU-F at 2, 4, and 6 weeks after infection. The number of CFU-F in FeLV-KT-infected cats ranged from 38 to 70% of the preinoculation CFU-F value. Of 3 cats with FeLV-KT-induced suppression of CFU-F, 2 developed fatal nonregenerative anemia. Cats infected with the Rickard isolate of FeLV (FeLV-R) had more moderate decrease in the number of CFU-F at 2, 4, and 6 weeks after infection. The number of CFU-F in FeLV-R-infected cats ranged from 62 to 82% of the preinoculation CFU-F value. The FeLV-R-infected cats did not become anemic.
Wellman
M L
ML
Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Kociba
G J
GJ
Mathes
L E
LE
D000740:Anemia / Q000662:veterinary; D000818:Animals; D001853:Bone Marrow / Q000276:immunology*; D002415:Cats; D002455:Cell Division; D005347:Fibroblasts / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007108:Immune Tolerance; D005256:Leukemia Virus, Feline / Q000276:immunology*; D016582:Leukemia, Feline / Q000276:immunology*; D013234:Stem Cells / Q000276:immunology*; D014766:Viremia / Q000662:veterinary