Beta-receptor decrease in bronchial asthma.
Sinesterases that intervene in cAMP and oGMP equilibrium in the cytoplasm of mast cells are activated by the adrenergic system through beta-receptors. A study was made on 96 atopic patients with mono sensitization to Dermatophagoides pteronissinus, in 3 groups. Radioligands were used to quantitate the number of beta receptors. In the control group mean no/cell was 541, bronchial symptomatic patients had 327 and nasal symptomatics 348. Asymptomatic patients were similar to controls. The results were similar with pollen-sensitive patients. Beta receptor decrease is a consequence of clinical allergy in atopic patients and is secondary to the immunological events that follow antigen-antibody reactions and cell membrane changes.
Oehling
A
A
Departemento de alergologia e inmunología Clínica, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain.
Sanz
M L
ML
Gamboa
P M
PM
D000262:Adenylyl Cyclases / Q000378:metabolism; D000485:Allergens / Q000276:immunology; D000818:Animals; D001249:Asthma / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000503:physiopathology; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004789:Enzyme Activation; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications / Q000276:immunology / Q000378:metabolism*; D008407:Mast Cells / Q000737:chemistry*; D008925:Mites / Q000276:immunology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000032:analysis* / Q000502:physiology; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction
D000485:Allergens; D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D000262:Adenylyl Cyclases; D006152:Cyclic GMP