title: Prognostic significance of DNA ploidy in male breast carcinoma. A retrospective analysis of 32 cases.
abstract: BACKGROUND
  DNA aneuploidy has been prognostically significant in female breast carcinoma of low stage, but its value in male breast carcinoma remains undetermined.
  
  
  METHODS
  Flow cytometric DNA analyses were performed retrospectively on paraffin-embedded tissue from 32 men with breast carcinoma (mean follow-up time, 5.97 years [standard deviation +/- 4.63]; range, 1 to 18 years).
  
  
  RESULTS
  Multivariate discriminant function analysis showed only tumor size less than 2 cm to be independently predictive of better disease-free survival (P less than 0.05). DNA ploidy (aneuploid, 25 patients; diploid, 7 patients) and lymph node status (positive, 22 patients; negative, 10 patients) were not predictive of survival, regardless of tumor size.
  
  
  CONCLUSIONS
  The authors concluded that DNA ploidy may not significantly predict survival in male breast carcinoma.
authors.affiliation: Department of Pathology, Loyola University Medical Center, Maywood, IL 60153.
authors.forename: P
authors.initials: P
authors.lastname: Gattuso
authors.forename: V B
authors.initials: VB
authors.lastname: Reddy
authors.forename: L
authors.initials: L
authors.lastname: Green
authors.forename: M
authors.initials: M
authors.lastname: Castelli
authors.forename: D
authors.initials: D
authors.lastname: Haley
authors.forename: C
authors.initials: C
authors.lastname: Herman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D004273:DNA, Neoplasm / Q000235:genetics*; D004171:Diploidy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011003:Ploidies; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D004273:DNA, Neoplasm