Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.
The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.
Hilbert
P
P
Centre d'Etude du Polymorphisme Humain, Paris, France.
Lindpaintner
K
K
Beckmann
J S
JS
Serikawa
T
T
Soubrier
F
F
Dubay
C
C
Cartwright
P
P
De Gouyon
B
B
Julier
C
C
Takahasi
S
S
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D008040:Genetic Linkage; D006973:Hypertension / Q000235:genetics*; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D016133:Polymerase Chain Reaction; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics; D011921:Rats, Inbred WKY / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D017475:Receptors, Nerve Growth Factor; D011986:Receptors, Somatotropin / Q000235:genetics; D014960:X Chromosome
D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor; D011986:Receptors, Somatotropin; D007703:Peptidyl-Dipeptidase A