title: Importance of district of residence and known primary site for bowel cancer survival: analysis of data from Wessex Cancer Registry.
abstract: OBJECTIVE
  The aim was to compare survival with colon and rectal cancer across the 10 districts of Wessex taking into account the age and sex of the individual.
  
  
  METHODS
  The study was based on registrations on the Wessex Cancer Registry between 1979 and 1984 with colon and rectal cancer. Survival up to 31 December 1986 was examined using a Cox regression model; individuals surviving to the end of the follow up period were treated as censored in the analysis. Survival was examined in the first fortnight, the first month, and the first six months after registration separately.
  
  
  METHODS
  The data comprised 6239 residents of the Wessex Region who had been diagnosed with colon cancer and 3203 residents diagnosed with rectal cancer. For 140 cases survival data or age were missing and these cases were excluded.
  
  
  RESULTS
  Results are presented in the format of a league table giving the order of districts from lowest to highest survival rates. No significant differences in survival are found between districts in relation to rectal cancer. We find that one or two districts have consistently high or low survival rates with colon cancer in various periods of follow up, but cannot differentiate between the districts in the centre of the list. Site unspecified is considered as an explanatory variable; it is more predictive than district, and it approaches the importance of age in explaining survival with colon cancer.
  
  
  CONCLUSIONS
  There are significant differences in survival with colon cancer between districts; however data on stage at registration are not available and we are unable to say whether the differences in survival are due to differences in stage at diagnosis or differences in survival with similar stage at diagnosis. We found that cases where the site of the cancer within the colon was not recorded on the register have significantly lower survival, and we suggest that site unspecified may be related to stage at diagnosis.
authors.affiliation: University of Southampton, Southampton General Hospital, U.K.
authors.forename: R M
authors.initials: RM
authors.lastname: Pickering
authors.forename: I R
authors.initials: IR
authors.lastname: Chadwell
authors.forename: L
authors.initials: L
authors.lastname: Mountney
mesh_terms: D000367:Age Factors; D002391:Catchment Area, Health / Q000706:statistics & numerical data*; D003110:Colonic Neoplasms / Q000401:mortality*; D004739:England / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D009382:Neoplasms, Unknown Primary; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality*; D012042:Registries; D012111:Residence Characteristics; D016019:Survival Analysis; D013997:Time Factors