title: Serum paraoxonase polymorphism in three populations of southeast Asia.
abstract: Serum paraoxonase hydrolyzes paraoxon, the principal metabolite of the insecticide parathion. Serum paraoxonase is polymorphic and controlled by two codominant alleles - PON*A and PON*B representing low and high activity, respectively. Three populations of southeast Asia comprising 194 Chinese, 159 Filipinos and 73 Dravidian Indians were investigated for serum paraoxonase polymorphism. The frequency of PON*B was found to be 0.14 in the Chinese, 0.04 in the Filipinos and 0.18 in Dravidian Indians. The distribution of the PON phenotypes was at Hardy-Weinberg equilibrium in all the three populations studied.
authors.affiliation: Department of Obstetrics and Gynaecology, National University of Singapore.
authors.forename: A C
authors.initials: AC
authors.lastname: Roy
authors.forename: N
authors.initials: N
authors.lastname: Saha
authors.forename: J S
authors.initials: JS
authors.lastname: Tay
authors.forename: S S
authors.initials: SS
authors.lastname: Ratnam
mesh_terms: D043303:Aryldialkylphosphatase; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010744:Phosphoric Monoester Hydrolases / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012846:Singapore / Q000208:ethnology
chemical_list: D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase