[Strict anaerobic bacteria: comparative study of various beta-lactam antibiotics in combination with tazobactam or sulbactam].
The minimal inhibitory concentrations of piperacillin (PIP) or cefotaxime (CTX) alone or in combination with tazobactam (TAZ) were determined against 168 anaerobes. All the strains were inhibited by PIP + TAZ, but certain strains resistant to CTX + TAZ were found among B. fragilis, Eubacterium and Peptostreptococcus. The second investigations included 30 strains of Bacteroides fragilis. Concentrations of 2, 4 and 8 mg/l of TAZ and sulbactam (SUL) were combined with piperacillin or cefotaxime. The two beta-lactamase-inhibitors had similar activities when used at 2 or 4 mg/l, but at 8 mg/l TAZ was more active than SUL. All B. fragilis strains were inhibited by PIP + TAZ or PIP + SUL, whereas resistance was observed with CTX + SUL or CTX + TAZ. On the same strains the activities of 6 beta-lactams (PIP, mezlocillin, ticarcillin (TIC), CTX, ceftriaxone and ceftazidime) were determined in combination with either SUL 4 mg/l or TAZ 8 mg/l. Only PIP or TIC + SUL or TAZ were able to inhibit at least 90% of tested strains. No resistance could be detected with PIP + TAZ combination. As conclusion, the two inhibitors when combined with PIP or TIC offered greater activity against both Gram positive or negative anaerobes and PIP + TAZ remained the more potent combination.
Dubreuil
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L
Faculté de Pharmacie, Laboratoire de Microbiologie, Lille, Annecy.
Sedallian
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002439:Cefotaxime / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004357:Drug Synergism; D066298:In Vitro Techniques; D010397:Penicillanic Acid / Q000494:pharmacology*; D010878:Piperacillin / Q000494:pharmacology*; D013407:Sulbactam / Q000494:pharmacology*; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D065093:beta-Lactamase Inhibitors; D010397:Penicillanic Acid; D002439:Cefotaxime; D013407:Sulbactam; D000078142:Tazobactam; D010878:Piperacillin
Anaérobies stricts: activités comparées de diverses associations de bêtalactamines avec le tazobactam ou le sulbactam.