Non-Hodgkin's lymphoma after prolonged remission of Hodgkin's disease in an HIV-infected patient.
Hodgkin's disease was diagnosed in a 22-year-old HIV-seropositive man in 1986. Alternate MOPP/ABVD chemotherapy induced a clinical remission. He was asymptomatic until 3 years later when fever and peripheral and mediastinal lymphadenopathy appeared. Lymph node biopsy showed a large-cell anaplastic lymphoma and EBV genome was identified in the malignant cells, suggesting that transformation might had been induced by EBV. The present case affirms that in patients with HIV-related lymphomas who present enlarging lymphadenopathy after stable remission, the development of lymphomas of higher malignancy needs to be ruled out.
Montalban
C
C
Department of Internal Medicine, Hospital Ramon y Cajal, Madrid, Spain.
Bellas
C
C
Rodriguez-Garcia
J L
JL
Aguado
M
M
Fernandez-Muñoz
R
R
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001706:Biopsy; D015658:HIV Infections / Q000150:complications*; D006679:HIV Seropositivity / Q000150:complications*; D006258:Head and Neck Neoplasms / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000150:complications* / Q000628:therapy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications*; D008297:Male; D012074:Remission Induction