Differential response of retinoic acid pretreated human synovial sarcoma cell line to anticancer drugs.
The response of tumorigenic human synovial sarcoma (HSS) cell line to 10(-5)M optimum concentration of retinoic acid (RA) included changes in morphology, growth rate, suppression of anchorage-independent growth, induction of high alkaline phosphatase activity and excessive secretion of a 68 kDA glycoprotein of unknown function. HSS cells pretreated with 10(-5)M RA exhibited differential response to 3 potent anticancer drugs, namely cisplatin, vincristine and adriamycin. Sensitivity of the cells to cisplatin was found to be considerably enhanced after exposure to retinoic acid.
Adwankar
M
M
Chemotherapy Division, Cancer Research Institute, Tata Memorial Centre, Parel, Bombay, India.
Banerji
A
A
Ghosh
S
S
D000469:Alkaline Phosphatase / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D006801:Humans; D011292:Premedication; D013584:Sarcoma, Synovial / Q000188:drug therapy* / Q000201:enzymology; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014410:Tumor Stem Cell Assay; D014750:Vincristine / Q000494:pharmacology
D000970:Antineoplastic Agents; D014212:Tretinoin; D014750:Vincristine; D004317:Doxorubicin; D000469:Alkaline Phosphatase; D002945:Cisplatin