Mitomycin C and lipiodol do not improve the effect of intermittent hepatic artery occlusion on liver tumour growth. An experimental study in the rat.
The effect of Mitomycin C (MMC 2.0 mg/kg bw), lipiodol (0.2 ml/kg bw) and intermittent hepatic artery occlusion on liver tumour growth, as well as their possible interrelation, were studied in 29 rats. An adenocarcinoma was inoculated in the left liver lobe. After one week, the tumour size was measured and the rats then divided into five different groups of treatment. Intermittent hepatic artery occlusion was performed during five days for 1 hour daily alone, of initially in combination with MMC and lipiodol. One group was treated with MMC and lipiodol in combination and one group with lipiodol only. The tumour growth six days later was compared between the groups and with control rats. It was found that intermittent arterial occlusion significantly reduced the tumour growth (P = 0.01). However, the retarding effect of intermittent arterial occlusion on tumour growth was not significantly improved with additional treatment of MMC and lipiodol.
Sjövall
S
S
Department of Surgery, Lund University Hospital, Sweden.
Foss
A
A
Audisio
R
R
Ahrén
B
B
Bengmark
S
S
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced; D003250:Constriction; D004621:Embolization, Therapeutic; D006499:Hepatic Artery; D007459:Iodized Oil / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000628:therapy*; D008769:Methylnitronitrosoguanidine; D016685:Mitomycin / Q000494:pharmacology*; D051381:Rats; D011920:Rats, Inbred WF
D008769:Methylnitronitrosoguanidine; D016685:Mitomycin; D007459:Iodized Oil