title: [Bronchial asthma associated with primary lung cancer--comparison of extrathoracic malignancies].
abstract: Regarding 249 bronchial asthma patients having been admitted to our division for the recent 9 years, clinical manifestations of 8 bronchial asthma with primary lung cancer (group A; squamous cell carcinoma--5 cases, adenocarcinoma--2 cases, small cell carcinoma--1 case; 3.2% of 249 cases) and 8 asthma patients with extrathoracic malignancy (group B; gastric cancer--3 cases, malignant lymphoma--2 cases, bladder cancer--1 case, laryngeal cancer--1 case, prostatic cancer--1 case) were investigated. In group A, the mean of asthmatic history was 19 years and all cases were associated with respiratory tract infections. Three of 8 patients, were mild type and other 5 were moderate type. In group B, the mean of asthmatic history was 20 years and all cases were involved with respiratory tract infections. Five of 8 patients were mild type and other 3 were moderate type. The mean smoking (Brinkmann) index (1194) in group A was significantly higher than that (166) in 241 asthmatic patients without lung cancer or that (169) in group B. The median survival duration (more than 26 months) of group A patients was significantly lower than that (more than 77 months) of group B. These results suggested that, in many bronchial asthma patients accompanied by primary lung cancer who have adult-typed infectious asthmatic history, smoking exposure and aging are deeply related to the development of lung cancer.
authors.affiliation: Department of Medicine, Kawasaki Medical School.
authors.forename: S
authors.initials: S
authors.lastname: Umeki
authors.forename: K
authors.initials: K
authors.lastname: Hashiguchi
authors.forename: N
authors.initials: N
authors.lastname: Okimoto
authors.forename: R
authors.initials: R
authors.lastname: Soejima
mesh_terms: D000230:Adenocarcinoma / Q000150:complications; D000368:Aged; D000375:Aging; D001249:Asthma / Q000150:complications*; D018288:Carcinoma, Small Cell / Q000150:complications; D002294:Carcinoma, Squamous Cell / Q000150:complications; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008223:Lymphoma / Q000150:complications; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012907:Smoking; D013274:Stomach Neoplasms / Q000150:complications; D001749:Urinary Bladder Neoplasms / Q000150:complications