title: Chronic haloperidol treatment attenuates receptor-mediated phosphoinositide turnover in rat brain slices.
abstract: The long-term effects of haloperidol on phosphoinositide turnover in rat brain slices were investigated. Continuous treatment with haloperidol decanoate (21 mg/kg I.M. biweekly for 6 weeks) significantly attenuated carbachol- and norepinephrine (NE)-induced inositol phosphate accumulation in rat frontal cortex and hippocampus. In the striatum, the haloperidol treatment also significantly decreased carbachol-stimulated inositol phosphate level but did not significantly affect NE-sensitive phosphoinositide turnover. These effects were not observed in rats treated with a single dose of haloperidol (1.5 mg/kg). Basel levels of inositol phosphate in these 3 brain regions did not change following continuous or single haloperidol doses.
authors.affiliation: Neuropsychiatry Branch, NIMH Neuroscience Center, St. Elizabeths, Washington, DC 20032.
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: L L
authors.initials: LL
authors.lastname: Wing
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: R J
authors.initials: RJ
authors.lastname: Wyatt
authors.forename: D G
authors.initials: DG
authors.lastname: Kirch
authors.forename: D M
authors.initials: DM
authors.lastname: Chuang
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002217:Carbachol / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010716:Phosphatidylinositols; D002217:Carbachol; D006220:Haloperidol; D009638:Norepinephrine