[The cholinergic modulation of the pressor reaction to angiotensin].
I.v. administration of acetylcholine or acetylcholine plus neostigmine produced a dose-dependent decrease of angiotensin pressor response to 59.2, 39.9, and 26.8% of basal level at 10(-7), 10(-6), and 10(-5) M/kg, resp., and to 76.4 and 56.7% of basal level at 10(-6) and 10(-5) M/kg of neostigmine in anesthetized rats. Atropine prevented these effects and increased the angiotensin pressor response to 142.1 and 168.9% of basal level at 10(-7) and 10(-6) M/kg, resp., in intact rats. The cholinergic system seems to attenuate angiotensin effect on arterial pressure.
Fedorov
V I
VI
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D008297:Male; D009392:Nephrectomy; D010277:Parasympathomimetics / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D010277:Parasympathomimetics; D011950:Receptors, Cholinergic; D000804:Angiotensin II
Kholinergicheskaia moduliatsiia pressornoĭ reaktsii na angiotenzin.