Site-specific recombination and shuffling of resistance genes in transposon Tn21.
Many multidrug-resistant transposons found in natural isolates of Gram-negative bacteria are close relatives of Tn21. Thus, the Tn21 subgroup of the Tn3 family of transposable elements is the most successful homogeneous group in acquiring resistance to newly introduced antibiotics. This paper summarizes the mode of acquisition of resistance genes by these elements.
Avila
P
P
Dpto. Biologia Molecular, University of Cantabria, Santander, Spain.
de la Cruz
F
F
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D004251:DNA Transposable Elements / Q000187:drug effects* / Q000502:physiology; D004269:DNA, Bacterial / Q000235:genetics; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000235:genetics; D066298:In Vitro Techniques; D008969:Molecular Sequence Data
D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements; D004269:DNA, Bacterial