Cytotoxicity of transferrin-daunorubicin conjugates on small cell carcinoma of the lung (SCCL) cell line NCI-H69.
We have evaluated the effectiveness of daunorubicin against an SCCL cell line (NCI-H69) after conjugation to transferrin. Our results show that the conjugate is at least 10 times more active than the free drug in this in vitro system.
Béjaoui
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Department of Biochemistry, Faculty of Medicine, Université Laval, Québec, Canada.
Pagé
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Nöel
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D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000188:drug therapy*; D003630:Daunorubicin / Q000494:pharmacology*; D004338:Drug Combinations; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000188:drug therapy*; D011990:Receptors, Transferrin / Q000032:analysis; D014168:Transferrin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D004338:Drug Combinations; D011990:Receptors, Transferrin; D014168:Transferrin; D003630:Daunorubicin