title: An opioid pancreatic peptide produces ileal muscle inhibition and naloxone-reversible analgesia.
abstract: The opioid activity of immunoreactive beta-endorphin-like peptide extracted from pork pancreas duplicates the effects of morphine and synthetic beta-endorphin when measured by inhibition of isolated guinea pig ileal muscle response to electro-stimulation in vitro and by morphine-like analgesia following intravenous injection in the mouse. These responses are reversed by the opiate antagonist naloxone, indicating that a potent opioid mu receptor binding ligand is present in pancreatic extract. These findings imply a pancreatic source of plasma immunoreactive beta-endorphin that may explain a number of physiological and behavioral effects generally attributed to hypophyseal beta-endorphin alone.
authors.affiliation: Virginia Mason Research Center, Seattle, WA 98101.
authors.forename: C D
authors.initials: CD
authors.lastname: Kimball
authors.forename: M
authors.initials: M
authors.lastname: Iqbal
authors.forename: J T
authors.initials: JT
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Sutton
mesh_terms: D000700:Analgesics; D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D010147:Pain Measurement; D010187:Pancreatic Hormones / Q000302:isolation & purification / Q000378:metabolism; D011957:Receptors, Opioid / Q000378:metabolism; D001615:beta-Endorphin / Q000302:isolation & purification / Q000378:metabolism
chemical_list: D000700:Analgesics; D010187:Pancreatic Hormones; D011957:Receptors, Opioid; D009270:Naloxone; D001615:beta-Endorphin