Detoxification of an aliphatic amine by N-acetylation: experimental and clinical studies.
Incubation of serum serpin (alpha-1-antitrypsin) with 5 mM 1,6-diaminohexane causes significant loss of heterozygotic inhibitor activity. While serpin genes have several alleles, the enzyme complex that acetylates the amine to render it suitable for excretion has primarily two phenotype populations, i.e. slow and fast N-acetylators. This study shows that diacetyl-1,6-diaminohexane does not cause in vitro loss of serpin activity, and that all regional cases (eleven in all) referred to us during one year with a diagnosis of occupational organic diisocyanate asthma were slow acetylators except one who presented a marginally fast reaction type.
Berode
M
M
Institute of Occupational Health Sciences, University of Lausanne, Switzerland.
D000107:Acetylation; D001249:Asthma / Q000139:chemically induced* / Q000378:metabolism; D003959:Diamines / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008658:Inactivation, Metabolic; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects* / Q000493:pharmacokinetics; D000515:alpha 1-Antitrypsin / Q000235:genetics / Q000378:metabolism*
D003959:Diamines; D000515:alpha 1-Antitrypsin; D014051:Toluene 2,4-Diisocyanate; C007297:1,6-diaminohexane