[The study of Chinese herbal medicinal prescription with enzyme inhibitory activity. V. The study of hange-shashin-to, kanzo-shashin-to, shokyo-shashin-to with adenosine 3',5'-cyclic monophosphate phosphodiesterase].
Fifty-nine species of extracts of Chinese herbal medicinal prescription were tested for inhibitory activity of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase (PDE). Kanzo-shashin-to showed the highest activity in these prescriptions. Kanzo-shashin-to, Hange-shashin-to and Shokyo-shashin-to, whose contracting crude drugs were very similar, were especially studied among these prescriptions. Pinellia tuber acted as an ascent component for Scutellaria root and a mitigatory component for Giycyrrhiza. Jujube acted as a mitigatory component for Glycyrrhiza. Ginger acted as an additional component for Scutellaria root in cAMP PDE test. This additional effect of 6-gingerol, 6-shogaol from Ginger and baicalin from Scutellaria root were investigated.
Suzuki
M
M
Toho University, School of Phamaceutical Sciences, Chiba, Japan.
Nikaido
T
T
Ohmoto
T
T
D002396:Catechols / Q000302:isolation & purification / Q000494:pharmacology; D000242:Cyclic AMP / Q000037:antagonists & inhibitors*; D004338:Drug Combinations; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000494:pharmacology*
D002396:Catechols; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C040115:shogaol; D000242:Cyclic AMP