title: Metabolism of carbamazepine: evidence of autoinduction in Chinese.
abstract: To investigate the autoinduction of carbamazepine (CBZ) metabolism in Chinese, eleven healthy male volunteers joined in this study. There were two phases of drug administration with a wash-out interval of one month, 400 mg CBZ was taken orally in single-dose phase, and 200 mg three times per day were given for seven days in multiple-dose phase. Plasma samples were obtained in series of time after the last dose of drug in each phase. CBZ concentrations were determined by a high pressure liquid chromatography method. A non-linear regression program was applied in a personal computer to estimate the pharmacokinetic parameters. The average CBZ half-lives in single- and multiple-dose phases were 50.1 +/- 12.1 (mean +/- SD) hours and 26.1 +/- 4.2 hours and the clearances were 16.4 +/- 3.3 ml/kg/h and 45.3 +/- 23.4 ml/kg/h respectively, both with significant differences (p less than 0.005). There is evidence to support the presumption of autoinduction in Chinese.
authors.affiliation: Department of Neurology, National Cheng-Kung University Medical Center, Taiwan, R.O.C.
authors.forename: T S
authors.initials: TS
authors.lastname: Lin
authors.forename: M L
authors.initials: ML
authors.lastname: Lai
authors.forename: J D
authors.initials: JD
authors.lastname: Huang
mesh_terms: D000328:Adult; D044466:Asian People; D002220:Carbamazepine / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000378:metabolism; D013624:Taiwan
chemical_list: D002220:Carbamazepine; D010672:Phenytoin