[The negative effect of enkephalins on kidney energetics in rats with hemorrhages].
Content of adenine nucleotides, lactic and pyruvic acids, glucose and fructose-6-phosphate was studied in kidney of rats with hemorrhage constituting 3% of body mass after intravenous administration at a dose of 100 mg/kg of agonists of mu-opiate receptors DAGO and delta-opiate receptors DADL and dalargin. Stimulation of both these types of receptors amplifies the kidney ischemia developed after hemorrhage, which was expressed as increased decomposition of ATP, decrease in energetic charge of the adenine nucleotide system (DAGO) and increase in content of AMP (DADL, dalargin).
Slepushkin
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Grässler
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Scheuch
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D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D016308:Enkephalin, Leucine-2-Alanine / Q000494:pharmacology; D004745:Enkephalins / Q000494:pharmacology*; D005636:Fructosephosphates / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D006470:Hemorrhage / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu
D000227:Adenine Nucleotides; D004745:Enkephalins; D005636:Fructosephosphates; D005958:Glucosephosphates; D007773:Lactates; D011773:Pyruvates; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D019344:Lactic Acid; D019298:Glucose-6-Phosphate; D016308:Enkephalin, Leucine-2-Alanine; C027618:fructose-6-phosphate; D019289:Pyruvic Acid; D005947:Glucose
Otritsatel'noe deĭstvie énkefalinov na énergetiku pochek u krys s gemorragieĭ.