title: Reduction in tumor burden allowing partial nephrectomy following preoperative chemotherapy in biopsy proved Wilms tumor.
abstract: During the last 6 years a treatment protocol of radiographic staging along with percutaneous biopsy to establish a histological diagnosis has been used in 37 patients with Wilms tumor. Combination chemotherapy was given for 4 to 6 weeks before definitive surgical resection. In 9 patients tumor shrinkage was sufficient to permit preservation of a portion of the affected kidney(s). In stage V disease partial nephrectomy was accomplished in 5 patients. In 4 additional patients with unilateral disease downstaging also allowed partial nephrectomy. The radiological and histological changes that allowed this limited surgery are analyzed and compared.
authors.affiliation: Division of Urology, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: G A
authors.initials: GA
authors.lastname: McLorie
authors.forename: P H
authors.initials: PH
authors.lastname: McKenna
authors.forename: M
authors.initials: M
authors.lastname: Greenberg
authors.forename: P
authors.initials: P
authors.lastname: Babyn
authors.forename: P
authors.initials: P
authors.lastname: Thorner
authors.forename: B M
authors.initials: BM
authors.lastname: Churchill
authors.forename: S
authors.initials: S
authors.lastname: Weitzman
authors.forename: R
authors.initials: R
authors.lastname: Filler
authors.forename: A E
authors.initials: AE
authors.lastname: Khoury
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D009392:Nephrectomy / Q000379:methods*; D011292:Premedication; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin