[The hormonal regulation of mRNA Na,K-ATPase expression in rat kidneys in postnatal ontogeny].
A study was made of effects of aldosterone, aldosterone+dexamethasone, and aldosterone+spironolactone on Na,K-ATPase mRNA expression in renal cortex of adult and 10 day old rats, when kidney is not sensitive to the hormone injection. It is shown that hormonal induction of synthesis of Na,K-pump mRNA occurs in the early postnatal period apart from mineral corticoid receptors. It seems probable that aldosterone exerts its action in 10 day old rats by interaction with glucocorticoid receptors inducing synthesis of different amounts of alpha- and beta-subunits of Na,K-ATPase.
Logvinenko
N S
NS
Khlebodarova
T M
TM
Solenov
E I
EI
Ivanova
L N
LN
Broude
N E
NE
Monastyrskaia
G S
GS
D000315:Adrenalectomy; D000375:Aging / Q000187:drug effects / Q000502:physiology; D000450:Aldosterone / Q000494:pharmacology; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects* / Q000502:physiology; D007672:Kidney Cortex / Q000201:enzymology / Q000254:growth & development; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000096:biosynthesis / Q000187:drug effects / Q000235:genetics*; D013148:Spironolactone / Q000494:pharmacology
D012333:RNA, Messenger; D013148:Spironolactone; D000450:Aldosterone; D003907:Dexamethasone; D000254:Sodium-Potassium-Exchanging ATPase
Gormonal'naia reguliatsiia ékspressii mRNK Na,K-ATFazy v pochkakh v postnatal'nom ontogeneze.