Tumor immunity generated in the course of regression of v-src-induced sarcomas.
Previous studies have indicated that the regression versus progression of v-src-DNA-induced sarcomas is dependent on chicken line. As a first step in analyzing the role of tumor immunity as a determinant of this line dependence, experiments were undertaken to ascertain whether an antisarcoma immune response is generated in the course of sarcoma growth in TK chickens, a regressor line. To assay for this response, test TK chickens in which v-src-induced wing web sarcomas had regressed, as well as control TK chickens that had not been exposed to v-src, were challenged in protocols known to yield v-src-dependent sarcoma formation and monitored for challenge sarcoma growth. Compared with the control chickens, the test chickens showed a significant resistance to the sarcomagenic challenge. These results raise the possibility that the antisarcoma response that is inducible in regressor lines, as demonstrated here in terms of a protective effect against a subsequent sarcomagenic challenge, may also underlie the regression of v-src-induced primary sarcomas.
Wisner
T W
TW
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
England
J M
JM
Pan
D Y
DY
Stoker
A W
AW
Halpern
M S
MS
D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics* / Q000502:physiology; D002645:Chickens; D004273:DNA, Neoplasm / Q000302:isolation & purification; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D003673:Defective Viruses / Q000235:genetics / Q000502:physiology; D016391:Genes, src; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D010957:Plasmids; D015183:Restriction Mapping; D012513:Sarcoma, Experimental / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D013045:Species Specificity; D014779:Virus Replication / Q000235:genetics
D004273:DNA, Neoplasm; D004279:DNA, Viral