title: A clinico-pathological study of canine Cushing's disease caused by a pituitary carcinoma.
abstract: Knowledge of clinico-pathological correlations in canine Cushing's disease is rather poor. Therefore we describe, clinically and pathologically, a case of pituitary tumour-dependent Cushing's disease in an 8-year old female cocker spaniel. Based on our results, the tumour was defined as a non-dexamethasone-suppressive, corticotrophic adenocarcinoma characterized by some new findings such as intracerebral metastases of anti-ACTH-labelled tumour cells and combined alpha-, beta- and gamma 3-MSH immunoreactivity in the tumour.
authors.affiliation: Institute of Animal Pathology, University of Berne, Switzerland.
authors.forename: C E
authors.initials: CE
authors.lastname: Boujon
authors.forename: U
authors.initials: U
authors.lastname: Ritz
authors.forename: G L
authors.initials: GL
authors.lastname: Rossi
authors.forename: G E
authors.initials: GE
authors.lastname: Bestetti
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D002114:Calcinosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D003480:Cushing Syndrome / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D003907:Dexamethasone; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D010281:Parathyroid Hormone / Q000097:blood; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D013972:Thyrotropin; D013974:Thyroxine / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D010281:Parathyroid Hormone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D009074:Melanocyte-Stimulating Hormones; D013974:Thyroxine; D006854:Hydrocortisone