Progesterone, oestradiol, somatostatin and epidermal growth factor receptors on human meningiomas and their CT characteristics.
The presence of progesterone, oestrogen, somatostatin and epidermal growth factor receptors of 24 meningiomas was related with their radiological CT appearance. Progesterone receptors were present in 16 of 21 (76%), oestrogen receptors in 4 of 21 (19%), somatostatin receptors on 23 of 24 (96%) and epidermal growth factor receptors on 17 of 19 (89%) meningiomas. There was no relationship between the presence of these receptors and the age or sex of the patients, tumour histology, tumour localisation, the presence of perifocal oedema, displacement of the midline cerebri or obstructive hydrocephalus on CT scan. There was a negative correlation (P less than 0.05) between the number of progesterone receptors and "malignant" behaviour of the meningiomas on CT (e.g. the presence of necrosis, cyst formation, intratumoral haemorrhage, irregular surface and/or inhomogeneous attenuation of contrast). The observation that aggressive tumour behaviour on CT is accompanied by low numbers or absence of progesterone receptors makes these meningiomas less attractive candidates for medical therapy with antiprogestins.
Huisman
T W
TW
Department of Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Tanghe
H L
HL
Koper
J W
JW
Reubi
J C
JC
Foekens
J A
JA
Avezaat
C J
CJ
Braakman
R
R
Lamberts
S W
SW
D066246:ErbB Receptors / Q000032:analysis; D006801:Humans; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology; D008579:Meningioma / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology; D011956:Receptors, Cell Surface / Q000032:analysis*; D011959:Receptors, Estradiol / Q000032:analysis; D017981:Receptors, Neurotransmitter / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D017481:Receptors, Somatostatin; D014057:Tomography, X-Ray Computed
D011956:Receptors, Cell Surface; D011959:Receptors, Estradiol; D017981:Receptors, Neurotransmitter; D011980:Receptors, Progesterone; D017481:Receptors, Somatostatin; D066246:ErbB Receptors