Hybrid receptors.
Many hormone and growth factor receptors form homomeric oligomers. Subunits of related receptors can be mixed to form hybrid receptors. These can have novel ligand-binding and signaling properties. The additional flexibility that results from the ability to independently regulate the expression and function of different component subunits greatly increases the spectrum of cellular responses to extracellular signals.
Jacobs
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Burroughs Wellcome Co., Research Triangle Park, NC 27709.
Moxham
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D002352:Carrier Proteins / Q000502:physiology; D006801:Humans; D011940:Receptor Aggregation; D011972:Receptor, Insulin / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D017479:Receptors, Platelet-Derived Growth Factor; D018168:Receptors, Retinoic Acid; D017451:Receptors, Somatomedin; D011988:Receptors, Thyroid Hormone / Q000502:physiology; D014158:Transcription, Genetic; D016335:Zinc Fingers
D002352:Carrier Proteins; D011956:Receptors, Cell Surface; D018168:Receptors, Retinoic Acid; D017451:Receptors, Somatomedin; D011988:Receptors, Thyroid Hormone; D011972:Receptor, Insulin; D017479:Receptors, Platelet-Derived Growth Factor