[Effects of ibuprofen and OKY-046 on ventilation perfusion distribution in acute respiratory failure].
Hydrochloric acid was injected into the trachea to produce acute respiratory failure in 18 anesthetized dogs. Six dogs were pretreated with ibuprofen (12.5 mg/kg), six dogs were given OKY-046 (0.5 mg/kg), and the remaining six were taken as controls. Distribution of ventilation-perfusion was evaluated by inert gas elimination technique. Acid aspiration caused a prompt decline in PaO2 with an increased perfusion to shunt and low VA/Q lung regions. Pretreatment with ibuprofen reduced pulmonary blood flow to shunt and low VA/Q regions for the first 2 hours after acid aspiration and attenuated hypoxemia, causing an increase in PVR. However, OKY-046, a thromboxane synthetase inhibitor, did not ameliorate acid-induced VA/Q mismatching and hypoxemia.
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D000818:Animals; D004285:Dogs; D006851:Hydrochloric Acid; D007052:Ibuprofen / Q000494:pharmacology*; D008689:Methacrylates / Q000494:pharmacology*; D010992:Plethysmography, Impedance; D011652:Pulmonary Circulation / Q000187:drug effects; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects*
D008689:Methacrylates; D013930:Thromboxane-A Synthase; C034364:ozagrel; D006851:Hydrochloric Acid; D007052:Ibuprofen