title: The determination of platinum in biological tissue by instrumental neutron activation analysis.
abstract: Neutron activation analysis was used to determine platinum in the tissues of rats that had received doses of the tumor chemotherapy agent cis-Pt. Two elements causing spectral interference were identified as 47Sc from 46Ca, a natural component of tissue, and tin (117mSn), an element introduced inadvertently during necropsy and sample work-up. A protocol was devised to correct for interference, using emission lines from 47Ca and 113Sn, respectively, with appropriate consideration for relative detector efficiencies, decay times and half-lives.
authors.affiliation: University of Alberta SLOWPOKE Facility, Edmonton, Canada.
authors.forename: G W
authors.initials: GW
authors.lastname: Haverland
authors.forename: L I
authors.initials: LI
authors.lastname: Wiebe
mesh_terms: D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage; D009501:Neutron Activation Analysis; D010984:Platinum / Q000032:analysis*; D051381:Rats
chemical_list: D010984:Platinum; D002945:Cisplatin