[A rapid radionuclide method for clinical assessment of gastric juice proteolytic activity and acidity].
A new method for radionuclide measurement of gastric juice proteolytic activity (GJPA) is described. GJPA is determined according to the time of dissolution of the protein capsule filled with 99mTc-pertechnetate solution. In vitro experiments made with 342 samples of gastric juice revealed a correlation (p1 less than 0.01) between the time of dissolution of the 99mTc-pertechnetate capsule and proteolytic activity measured according to Metta's method. No correlation was established between GJPA (measured by Metta's method and by radionuclide method) and gastric juice acidity (p greater than 0.05). In 63 patients examined, the time of capsule dissolution was 15 to 18 minutes with GJPA being normal, 8 to 14 minutes (p less than 0.01) with elevated parameters of GJPA, and 19 to 37 minutes (p less than 0.01) with GJPA being reduced. The given method is a physiological one, sufficiently precise and can be recommended for a screening analysis of GJPA.
Popova
L V
LV
Sergienko
V B
VB
Amirov
N Sh
NSh
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000378:metabolism*; D013670:Sodium Pertechnetate Tc 99m; D013997:Time Factors
D013670:Sodium Pertechnetate Tc 99m; D010447:Peptide Hydrolases
Radionuklidnyĭ ékspress-metod klinicheskoĭ otsenki proteolitcheskoĭ aktivnosti i kislotnosti zheludochnogo soka.