title: Efficacy of enrofloxacin in the treatment of respiratory pasteurellosis in rabbits.
abstract: Fourteen New Zealand White rabbits with respiratory signs of naturally occurring Pasteurella multocida infections were treated with either an injectable or water-soluble oral formulation of enrofloxacin. Antimicrobial efficacy was evaluated by scoring clinical signs in the rabbits and recovery of the organisms. Seven (87%) of eight rabbits treated with the injectable regimen (5 mg/kg every 12 hours for 14 days) became culture-negative with no clinical signs within 72 hours after initiation of treatment. Six rabbits treated with the oral formulation (200 mg/liter of drinking water for 14 days) also became culture-negative and had no clinical signs 3 to 7 days after treatment began, but P. multocida was recovered from several sites in three (50%) rabbits. No rabbits showed any signs of gastroenteric disturbances.
authors.affiliation: Veterans Administration Medical Center, Research Service, Palo Alto, CA 94303.
authors.forename: R L
authors.initials: RL
authors.lastname: Broome
authors.forename: D L
authors.initials: DL
authors.lastname: Brooks
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones; D007279:Injections, Subcutaneous; D008297:Male; D010326:Pasteurella Infections / Q000188:drug therapy*; D016979:Pasteurella multocida; D015363:Quinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D011817:Rabbits; D012141:Respiratory Tract Infections / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin