Enhancement in beta-adrenergic responsiveness of adenylate cyclase in rat liver after galactosamine administration.
In rat liver at 48 hours after galactosamine (GalN) treatment, isoproterenol-induced accumulation of cyclic AMP and activation of adenylate cyclase (AC) were significantly enhanced. AC activity stimulated with GppNHp or NaF was also augmented in membranes from GalN-treated rats. However, the MnCl2-stimulated or forskolin-stimulated activity in GalN-treated rats did not differ from the control. These data suggest that the beta-adrenergic responsiveness of AC in rat liver is potentiated, possibly due to the enhanced function of the Gs protein, during the process of regeneration after GalN treatment.
Hatta
S
S
Department of Pharmacology, Sapporo Medical College, Japan.
Amemiya
N
N
Ohshika
H
H
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D004789:Enzyme Activation; D005688:Galactosamine / Q000008:administration & dosage / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D011943:Receptors, Adrenergic, beta; D005688:Galactosamine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D007545:Isoproterenol