[A comparison of the efficiency of vasoconstricting effects in spontaneously hypertensive and normotensive rats under different perfusion conditions].
The in vivo biomicroscopy of the m. extensor hallucis proprius revealed thickening of the arterioles walls in spontaneously hypertensive rats (SHRs) as compared with normotensive ones. However, the constrictor responses of the arterioles to standard sympathetic stimulation were 35-50% lesser in the SHRs. The experiments with perfusion of the hind-part of the body revealed reduced responses in the SHRs as well. Therefore, the specifics of morphofunctional structure of the resistive vessels' walls hinders a considerable increase in constrictor responses in the RHRs at a reduced transmural pressure.
Tarasova
O S
OS
Timkina
M I
MI
Rodionov
I M
IM
Koshelev
V B
VB
D000818:Animals; D001160:Arterioles / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D004558:Electric Stimulation; D006973:Hypertension / Q000503:physiopathology*; D009132:Muscles / Q000098:blood supply / Q000187:drug effects / Q000294:innervation; D010477:Perfusion / Q000379:methods; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D013564:Sympathetic Nervous System / Q000502:physiology; D014655:Vascular Resistance / Q000187:drug effects / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D014662:Vasoconstrictor Agents
Sravnenie éffektivnosti sosudosuzhivaiushchikh vliianiĭ u spontanno gipertenzivnykh i normotenzivnykh krys pri raznykh usloviiakh perfuzii.