title: Cellular retinoic acid-binding protein in rat lacrimal gland.
abstract: We employed a monoclonal antibody to cellular retinoic acid-binding protein (CRABP) to assess the presence and localization of this retinoid-binding protein in the lacrimal gland of the rat. Immunoblots of extracts of rat lacrimal gland showed specific immunostaining of lacrimal CRABP in the region 14-16 kDa. Sections of rat lacrimal glands that were stained with anti-CRABP antibodies showed reaction product in the cytoplasm of the acinar cells. Retinoic acid may play a role in maintaining the proper function of lacrimal gland cells.
authors.affiliation: Department of Ophthalmology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157.
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: V P
authors.initials: VP
authors.lastname: Gaur
authors.forename: R W
authors.initials: RW
authors.lastname: Young
authors.forename: A J
authors.initials: AJ
authors.lastname: Sweatt
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D002352:Carrier Proteins / Q000378:metabolism*; D015151:Immunoblotting; D007124:Immunoenzyme Techniques; D007765:Lacrimal Apparatus / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D018168:Receptors, Retinoic Acid; D013737:Testis / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D014212:Tretinoin