title: High-performance liquid chromatographic determination of ganciclovir in plasma.
abstract: A rapid, selective and sensitive isocratic reversed-phase high-performance liquid chromatographic method for the determination of ganciclovir in plasma samples was developed. This method, which was applied to the analysis of plasma ganciclovir from heart transplant patients under ganciclovir therapy for cytomegalovirus infections, represents a suitable analytical tool for drug monitoring and pharmacokinetic investigations.
authors.affiliation: Institut des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Clinique, Lyon, France.
authors.forename: R
authors.initials: R
authors.lastname: Boulieu
authors.forename: N
authors.initials: N
authors.lastname: Bleyzac
authors.forename: S
authors.initials: S
authors.lastname: Ferry
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology; D016903:Drug Monitoring; D015774:Ganciclovir / Q000097:blood* / Q000627:therapeutic use; D016027:Heart Transplantation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents
chemical_list: D007202:Indicators and Reagents; D015774:Ganciclovir