Cloning and chromosomal localization of a human endothelin ETA receptor.
A cDNA clone encoding a human endothelin receptor was isolated from a placenta cDNA library. The deduced amino acid sequence of the clone is 94% identical to the bovine endothelin ETA receptor and represents the human homologue. The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids.
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Department of Pharmacology, New York University Medical Center, New York 10016.
Huebner
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Druck
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D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D003001:Cloning, Molecular / Q000379:methods; D016232:Endothelins / Q000378:metabolism; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D008969:Molecular Sequence Data; D010957:Plasmids; D016133:Polymerase Chain Reaction; D051381:Rats; D011956:Receptors, Cell Surface / Q000235:genetics*; D017466:Receptors, Endothelin; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D016232:Endothelins; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin