title: Progesterone receptors in bilateral ovarian ependymoma presenting in pregnancy.
abstract: We present a case of a 25-year-old patient at term pregnancy who presented with a bilateral ovarian neoplasm that was histologically and immunohistochemically indistinguishable from ependymoma of the central nervous system. Progesterone receptors were detected in primary and recurrent neoplasms by immunohistochemistry. This is the first case of this rare neoplasm to present during pregnancy as well as with bilateral ovarian involvement. Together with a previously reported case of recurrent ovarian ependymoma with estrogen and progesterone receptors, this case suggests that hormonal responsiveness of this rare neoplasm may be pathogenically significant.
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor.
authors.forename: K A
authors.initials: KA
authors.lastname: Carr
authors.forename: J A
authors.initials: JA
authors.lastname: Roberts
authors.forename: T S
authors.initials: TS
authors.lastname: Frank
mesh_terms: D000328:Adult; D004806:Ependymoma / Q000737:chemistry / Q000150:complications / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000150:complications / Q000648:ultrastructure*; D010053:Ovary / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis* / Q000473:pathology; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D011980:Receptors, Progesterone