title: Itraconazole versus ketaconazole in the treatment of oral and oesophageal candidosis in patients infected with HIV.
abstract: To determine the efficacy and toxicity of two systemically active antifungal agents in the treatment of buccal and oesophageal candidiasis 111 HIV-infected patients with microscopically-confirmed candidiasis were randomized to receive either 200 mg itraconazole once a day or 200 mg ketoconazole twice a day for 28 days in a double blind study. After 1 week of treatment, 75 and 82% of the patients on itraconazole and ketoconazole, respectively, had responded clinically. After 4 weeks of treatment, this had risen to 93% in each group. One patient discontinued itraconozole because of toxicity (rash), five patients discontinued ketaconazole (two nausea, two hepatotoxicity and one rash). Despite successful clinical and mycological clearance, 80% patients had a further episode of candidosis within the next 3 months.
authors.affiliation: AIDS Unit, St. Stephens Clinic, London, UK.
authors.forename: D E
authors.initials: DE
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Midgley
authors.forename: M
authors.initials: M
authors.lastname: Allan
authors.forename: G M
authors.initials: GM
authors.lastname: Connolly
authors.forename: B G
authors.initials: BG
authors.lastname: Gazzard
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000188:drug therapy*; D002180:Candidiasis, Oral / Q000150:complications / Q000188:drug therapy; D004311:Double-Blind Method; D004935:Esophageal Diseases / Q000150:complications / Q000188:drug therapy; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications* / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole