title: Interleukin-1, interleukin-6: messengers in the neuroendocrine immune system?
abstract: Recent findings indicate that interleukin-1 (IL-1) and interleukin-6 (IL-6), cytokines secreted by immunologically activated monocytes and macrophages modulate neuroendocrine function. The site of production (centrally, peripherally), the site of action and the physiological significance of IL-1 and IL-6 as "classical hormones" are questioned.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Vrije Universiteit Brussel, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Hooghe-Peters
authors.forename: B
authors.initials: B
authors.lastname: Velkeniers
authors.forename: L
authors.initials: L
authors.lastname: Vanhaelst
authors.forename: R
authors.initials: R
authors.lastname: Hooghe
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007107:Immune System / Q000502:physiology*; D007375:Interleukin-1 / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D000324:Adrenocorticotropic Hormone