title: C cell hyperplasia and carcinoma developing in sheep with experimentally-induced lymphosarcoma.
abstract: Two cases of C cell hyperplasia and one case of C cell carcinoma of the thyroid glands were bilaterally recognized in 11 sheep with experimentally-induced lymphosarcoma. The serum calcium concentration in the C cell carcinoma case was slightly increased above the normal concentration of around 9 mg per dl. Bilateral C cell hyperplasia also developed in the thyroid lobes of the C cell carcinoma case. Immunohistochemically, hyperplastic C cells and tumour cells were positive for calcitonin, calcitonin gene-related peptide, chromogranin A and neurone-specific enolase. No amyloid deposition nor multiple endocrine neoplasia was demonstrated in any of the cases. Ultrastructurally, many secretory granules were observed in the cytoplasm of neoplastic cells constituting the C cell carcinoma and in the hyperplastic C cells.
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
authors.forename: K
authors.initials: K
authors.lastname: Matsukawa
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006965:Hyperplasia; D001909:Leukemia Virus, Bovine / Q000472:pathogenicity*; D008228:Lymphoma, Non-Hodgkin / Q000382:microbiology*; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology / Q000473:pathology*; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins