Organization of intracellular calcium signals generated by inositol lipid-dependent hormones.
Recent studies at the single cell level have demonstrated hitherto unsuspected complexities in the organization of intracellular Ca2+ homeostasis in both the temporal and spatial domains. Activation of receptors coupled to the phosphoinositide signalling system has been shown to generate [Ca2+]i oscillations in many cell types. These oscillations display diverse patterns, with variations in oscillation amplitude, latency and frequency which are often tissue and/or agonist dose specific. Furthermore, increases in [Ca2+]i can either occur uniformly or originate from a specific region and propagate throughout the cell in the form of a Ca2+ wave. The significance and underlying mechanisms responsible for these phenomena are discussed.
Rooney
T A
TA
Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107.
Thomas
A P
AP
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear; D015398:Signal Transduction
D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; C040985:phosphatidylinositol receptors; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium