The possible involvement of free radical scavenging properties in the actions of cytokines.
Among the cytokines which show an antiproliferative effect on certain tumor cells, we investigated the free radical scavenging properties of tumor necrosis factor-alpha, interferon-alpha, and interferon-gamma. The scavenging properties were determined in vitro by the ability to reduce DPPH free radicals. All of these cytokines exhibited marked DPPH free radical scavenging ability.
Matsubara
N
N
First Department of Surgery, Okayama University Medical School, Japan.
Fuchimoto
S
S
Iwagaki
H
H
Nonaka
Y
Y
Kimura
T
T
Kashino
H
H
Edamatsu
R
R
Hiramatsu
M
M
Orita
K
K
D015764:Bepridil / Q000031:analogs & derivatives / Q000737:chemistry; D001713:Biphenyl Compounds; D016207:Cytokines / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers; D007370:Interferon Type I / Q000737:chemistry; D007371:Interferon-gamma / Q000737:chemistry; D010851:Picrates; D014409:Tumor Necrosis Factor-alpha / Q000737:chemistry
D001713:Biphenyl Compounds; D016207:Cytokines; D016166:Free Radical Scavengers; D007370:Interferon Type I; D010851:Picrates; D014409:Tumor Necrosis Factor-alpha; D015764:Bepridil; D007371:Interferon-gamma; C004931:1,1-diphenyl-2-picrylhydrazyl