Denervation of the rabbit hind limb studied by 31-phosphorus magnetic resonance spectroscopy.
An animal model of muscle denervation was examined by 31P. magnetic resonance spectroscopy. The experiments demonstrated that there is a significant alteration in high and low energy phosphate metabolites in rabbit muscle after nerve section. The data show that there is an early change in the metabolites which appears to plateau at about six weeks. High resolution spectra of muscle cell extracts demonstrate qualitative alterations in the phosphate resonances found in the phosphodiester and phosphomonoester regions of the spectra. There would seem to be a time-related alteration in these components.
Frostick
S P
SP
M.R.C. Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford.
Dolecki
M J
MJ
Radda
G K
GK
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D004734:Energy Metabolism; D006614:Hindlimb / Q000293:injuries / Q000294:innervation; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010758:Phosphorus; D011817:Rabbits
D010710:Phosphates; D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate; D010744:Phosphoric Monoester Hydrolases; D010727:Phosphoric Diester Hydrolases