Postinfectious encephalitis in two siblings.
A 33-year-old man and his 32-year-old sister developed, with an interval of 2 years, an acute fatal encephalitis following an upper respiratory tract infection of unknown etiology. Autopsy documented postinfectious encephalitis in both. This is the first report of postinfectious encephalitis occurring in first degree relatives, suggesting that specific genetic factors play a role in the pathogenesis of this disease.
Laboyrie
P M
PM
Department of Neurology, University Hospital Leiden, The Netherlands.
Wintzen
A R
AR
Bots
G T
GT
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001921:Brain / Q000473:pathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D008297:Male; D009186:Myelin Sheath / Q000473:pathology; D012213:Rheumatic Fever / Q000235:genetics* / Q000276:immunology / Q000473:pathology
D001323:Autoantibodies