title: Urinary leukotriene E4 levels after allergen and exercise challenge in bronchial asthma.
abstract: Urinary leukotriene E4 (LTE4) concentrations were measured in six asthmatic subjects after treadmill exercise, and in five asthmatic subjects after allergen challenge. Exercise and allergen challenge produced a 42 +/- 18% (mean +/- SD) and 22 +/- 8% fall in FEV1, respectively. The baseline concentration of urinary LTE4 in subjects challenged with exercise was 64 (27 to 150) pg/mg creatinine (geometric mean and 95% confidence interval), and in those challenged with allergen it was 36 (23 to 59) pg/mg creatinine. Urinary LTE4 concentrations did not change significantly in the 24 h after exercise. In contrast, there was a mean 4-fold increase in urinary LTE4 during the 3 h after allergen challenge.
authors.affiliation: Department of Allergy and Allied Respiratory Disorders, Guy's Hospital, London, United Kingdom.
authors.forename: C M
authors.initials: CM
authors.lastname: Smith
authors.forename: P E
authors.initials: PE
authors.lastname: Christie
authors.forename: R J
authors.initials: RJ
authors.lastname: Hawksworth
authors.forename: F
authors.initials: F
authors.lastname: Thien
authors.forename: T H
authors.initials: TH
authors.lastname: Lee
mesh_terms: D000328:Adult; D001250:Asthma, Exercise-Induced / Q000175:diagnosis / Q000652:urine*; D001985:Bronchial Provocation Tests; D005080:Exercise Test; D005260:Female; D006801:Humans; D017999:Leukotriene E4; D008297:Male; D013189:SRS-A / Q000031:analogs & derivatives* / Q000652:urine; D013997:Time Factors
chemical_list: D013189:SRS-A; D017999:Leukotriene E4