[The effect of GABA-ergic preparations on the function of the hypothalamo-hypophyseal-adrenal system in patients with Itsenko-Cushing disease].
The effect of aminalon, baclofen and valproic acid on the levels of ACTH and cortisol was investigated in 58 patients with Itsenko-Cushing disease. The effect of GABAergic drugs showed correlation with the basal level of blood GABA: with aminalon and valproic acid the effect was observed only in patients with a low level of GABA, with baclofen--in patients with a high level of GABA there was found a decrease in the level of ACTH, associated with a high level of cortisol.
Mishunina
T M
TM
Kononenko
V Ia
VIa
Komissarenko
I V
IV
Luchitskiĭ
E V
EV
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D002908:Chronic Disease; D003480:Cushing Syndrome / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004341:Drug Evaluation; D005260:Female; D018756:GABA Antagonists; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects*; D011963:Receptors, GABA-A / Q000187:drug effects*; D013997:Time Factors; D014635:Valproic Acid / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
D018756:GABA Antagonists; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000324:Adrenocorticotropic Hormone; C008842:4-amino-3-phenylbutyric acid; D006854:Hydrocortisone
Vliianie GAMK-ergicheskikh preparatov na funktsional'noe sostoianie gipotalamo-gipofizarno-nadpochechnikovoĭ sistemy u bol'nykh bolezn'iu Itsenko--Kushinga.