Action spectra of the antileukemic and antiviral activities of merocyanine 540.
Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane-bound dye monomer, and by implication, the action spectrum of 1O2 generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane-bound monomer and at least in part mediated by 1O2.
O'Brien
J M
JM
Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226.
Singh
R J
RJ
Feix
J B
JB
Kalyanaraman
B
B
Sieber
F
F
D000818:Animals; D005456:Fluorescent Dyes / Q000528:radiation effects*; D006561:Herpes Simplex; D006801:Humans; D007938:Leukemia; D008566:Membranes / Q000528:radiation effects; D051379:Mice; D011744:Pyrimidinones / Q000528:radiation effects*; D018139:Simplexvirus / Q000528:radiation effects*; D013053:Spectrophotometry; D014407:Tumor Cells, Cultured
D005456:Fluorescent Dyes; D011744:Pyrimidinones; C003954:merocyanine dye