[Pharmakinetics of carboplatin in cancer patients].
Pharmakinetics of carboplatin was studied in 6 cancer patients who received carboplatin (300 mg/m2) by 30 minute intravenous infusion. Platinum plasma concentration was measured by reverse high performance liquid chromatography. The results showed that total platinum plasma clearance was biphasic in all patients with a short initial phase half-life of 1.27 hrs and a long second phase half-life of 6.92 hrs. The distribution volume of the drug was 57.78 L/m2 and area under the total platinum concentration curves was 84.71 mg/L.hr.
Zhang
M
M
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
D000328:Adult; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy*; D016190:Carboplatin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000097:blood / Q000188:drug therapy; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010984:Platinum / Q000097:blood
D010984:Platinum; D016190:Carboplatin