Stimulation of measles virus replication by cyclic guanosine monophosphate.
Measles virus (MV) replication in acutely infected human cells was markedly stimulated following exposure to guanosine 3',5'-monophosphate (cyclic GMP). Addition of cyclic GMP to tissue culture fluids immediately following infection with the virus resulted in acceleration of virus-mediated cell fusion, increased synthesis of virus-specified proteins and a 50-fold increase in infectious particle production. No evidence of altered viral protein phosphorylation was found. The results suggest that cyclic GMP stimulates multiple stages of the MV replication cycle.
Robbins
S J
SJ
Neurovirology Research Unit, Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital, Herston, Queensland, Australia.
D002460:Cell Line; D006152:Cyclic GMP / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007700:Kinetics; D008459:Measles virus / Q000187:drug effects / Q000502:physiology*; D014764:Viral Proteins / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects*
D014764:Viral Proteins; D006152:Cyclic GMP