Cellular immunity in splenectomized patients.
Delayed hypersensitivity and lymphocyte subsets in a group of adult splenectomized patients after abdominal trauma without associated disease have been studied. The results were compared with those observed in healthy individuals. The results show a decreased cutaneous reaction against extracts of Streptococcus and diphtheria antigens. Moreover, an increase in the number of lymphocytes and monocytes was observed, but the T4/T8 ratio was not affected. The impaired cutaneous response against Streptococcus could be related to post-splenectomy sepsis.
Balsalobre
B
B
Department of Biopathology, La Fe Hospital, Valencia, Spain.
Carbonell-Tatay
F
F
D000328:Adult; D016516:CD4-CD8 Ratio; D006801:Humans; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D007958:Leukocyte Count; D016131:Lymphocyte Subsets / Q000276:immunology; D008218:Lymphocytosis / Q000209:etiology / Q000276:immunology; D013156:Splenectomy / Q000009:adverse effects*