[Anti-anginal effects of calcium antagonists and intra-cardiac hemodynamics].
The intracardiac hemodynamics was studied in 33 patients with exertional angina pectoris undergoing an acute drug test with verapamil (n-15) and nifedipine (n-18) by using radionuclide ventriculography both at rest and during exercise. All the patients were divided into 2 groups by the increase in exercise duration with the two drugs: 1) those who exhibited a marked antianginal effect and 2) those without it. At rest, the calcium antagonists enhanced ejection fraction in the two groups. Exercise ejection fraction also increased, but in a subgroup of patients who displayed no higher exercise tolerance with verapamil. Verapamil and nifedipine in Group 1 patients resulted in lower left ventricular end diastolic volume. It is suggested that the antianginal effect of calcium antagonists is to a certain degree associated with decreased afterload, as manifested by diminished left ventricular end systolic volume.
Zeĭnalov
F I
FI
Malov
A G
AG
Mazur
N A
NA
Sergienko
V B
VB
Sumarokov
A B
AB
Rubanovich
A I
AI
D000328:Adult; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D002302:Cardiac Output / Q000187:drug effects* / Q000502:physiology; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology* / Q000627:therapeutic use; D015635:Radionuclide Ventriculography; D013670:Sodium Pertechnetate Tc 99m; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D013670:Sodium Pertechnetate Tc 99m; D014700:Verapamil; D009543:Nifedipine
Antianginal'nyĭ éffekt antagonistov kal'tsiia i vnutriserdechnaia gemodinamika.