The inhibition of oxytocin-induced grooming by a specific receptor antagonist.
The bilateral injection of the oxytocin receptor antagonist, N-acetyl-2-O-methyl-tyrosine-oxytocin (AMTO), in the nucleus accumbens of male rats prevented oxytocin-enhanced grooming without affecting locomotor activity. This effect was dose related. Oxytocin infusions did not alter open field activity. The present study investigated whether oxytocin receptors in the nucleus accumbens are essential for the expression of grooming enhanced by the neuropeptide.
Drago
F
F
Institute of Pharmacology, University of Catania Medical School, Italy.
Sarnyai
Z
Z
D'Agata
V
V
D057911:Angiotensin Receptor Antagonists; D000818:Animals; D006120:Grooming / Q000187:drug effects*; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D018045:Receptors, Oxytocin
D057911:Angiotensin Receptor Antagonists; D018045:Receptors, Oxytocin; C006380:oxytocin, N-acetyl-2-O-methyl-Tyr-; D010121:Oxytocin