Effects of catecholamine and serotonin in central nervous system in newborn mice with special reference to neural crest cells; presumptive evidence of neural crest origin.
Catecholamine and serotonin injected i.p. to new-born mice caused gliomas, ependymomas and choroid plexus papilloma together with multiple APUDomas within 48 hours after injection. We consider that an error in neural crest DNA may be caused through an adenylate-cyclic AMP system and Ca++ during replication and/or transcription. Multiple brain tumors caused by catecholamine and serotonin give the presumptive evidence that stem cells of neuroglia may be of neural crest origin.
Nozue
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AT
Department of Anatomy, Tokyo Medical and Dental University, Japan.
Ono
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D000818:Animals; D000831:Animals, Newborn; D001079:Apudoma / Q000139:chemically induced; D001254:Astrocytoma / Q000139:chemically induced; D001932:Brain Neoplasms / Q000139:chemically induced*; D002395:Catecholamines / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D004806:Ependymoma / Q000139:chemically induced; D005909:Glioblastoma / Q000139:chemically induced; D005910:Glioma / Q000139:chemically induced; D051379:Mice; D008813:Mice, Inbred ICR; D009432:Neural Crest / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*
D002395:Catecholamines; D012701:Serotonin; D000242:Cyclic AMP