title: Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3.
abstract: A gene encoding the endogenous superantigen Mlsc, which deletes Tcrb-V3+ T cells in the NOD inbred mouse strain, was found to co-segregate with Mtv-3 on chromosome 11. This identifies a fourth gene encoding a deletion ligand for Tcrb-V3+ T cells and extends recently published observations in support of the hypothesis that a number of endogenous superantigens are the products of Mtv proviruses.
authors.affiliation: Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, England.
authors.forename: S
authors.initials: S
authors.lastname: Fairchild
authors.forename: A M
authors.initials: AM
authors.lastname: Knight
authors.forename: P J
authors.initials: PJ
authors.lastname: Dyson
authors.forename: K
authors.initials: K
authors.lastname: Tomonari
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D005796:Genes; D008024:Ligands; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics; D051379:Mice; D016747:Minor Lymphocyte Stimulatory Antigens / Q000235:genetics*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D016662:Virus Integration
chemical_list: D008024:Ligands; D016747:Minor Lymphocyte Stimulatory Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta