[Idiopathic fibrosing alveolitis and bronchioloalveolar cancer].
A case of bronchiolo-alveolar carcinoma (BAC) developing in the presence of idiopathic fibrosing alveolitis (IFA) in a man of 67 with a long history of pulmonary lesion is described. A honeycomb bung was found at the autopsy. Histologically, multiple foci of BAC of mixed-cell structure and those of mucus-producing cells against the background of fibrosing alveolitis at the stage of honeycomb lung were observed. An increased content of collagen type III, IV and V was found immunohistochemically. The role of sclerotic changes and defected immunological surveillance over the epithelial regeneration in the IFA-affected lung in relevant carcinoma genesis is suggested. The origin of the lung carcinoma in IFA is considered to be the regenerating epithelium of the low respiratory tract.
Kogan
E A
EA
Kornev
B M
BM
Shukurova
R A
RA
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D000368:Aged; D003094:Collagen / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D008297:Male; D011658:Pulmonary Fibrosis / Q000150:complications / Q000378:metabolism / Q000473:pathology*
D003094:Collagen
Idiopaticheskiĭ fibroziruiushchiĭ al'veolit i bronkhiolo- al'veoliarnyĭ rak.