title: Phase II study of the amsacrine analogue CI-921 (NSC 343499) in non-small cell lung cancer.
abstract: CI-921 (NSC 343499; 9-[[2-methoxy-4-[(methylsulphonyl)amino]phenyl]amino] -N,5-dimethyl- 4-acridinecarboxamide) is a topoisomerase II poison with high experimental antitumour activity. It was administered by 15 min infusion to 16 evaluable patients with non-small cell lung cancer (NSCLC) (7 with no prior treatment, 9 patients in relapse following surgery/radiotherapy) at a dose (648 mg/m2 divided over 3 days, repeated every 3 weeks) determined by phase I trial. Patients had a median performance status of 1 (WHO), and median age of 61 years. The histology comprised squamous carcinoma (11), adenocarcinoma (1), mixed histology (2), bronchio-alveolar carcinoma (1) and large cell undifferentiated carcinoma (1). Neutropenia grade greater than or equal to 3 was seen in 15 patients, infections with recovery in 3, and grand mal seizures in 1 patient. Grade less than or equal to 2 nausea and vomiting occurred in 66% courses and phlebitis in the infusion arm in 37%. 1 patient with squamous cell carcinoma achieved a partial response lasting 5 months. Further testing in this and other tumour types using multiple daily schedules is warranted.
authors.affiliation: Department of Clinical Oncology, Auckland Hospital, New Zealand.
authors.forename: V J
authors.initials: VJ
authors.lastname: Harvey
authors.forename: J R
authors.initials: JR
authors.lastname: Hardy
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: W
authors.initials: W
authors.lastname: Grove
authors.forename: B C
authors.initials: BC
authors.lastname: Baguley
mesh_terms: D000328:Adult; D000368:Aged; D000677:Amsacrine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009503:Neutropenia / Q000139:chemically induced; D012640:Seizures / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D000677:Amsacrine; C042315:asulacrine