title: Onchocercacidal effects of amocarzine (CGP 6140) in Latin America.
abstract: An open clinical trial of amocarzine was carried out in onchocerciasis patients in Ecuador and Guatemala. Administration after food was more effective than that during fasting. The most effective and best tolerated regimen, 3 mg/kg twice daily after food for 3 days (in 312 patients), killed 73% of 1477 female worms at nodulectomy 4 months after treatment. The mean microfilarial skin count was greatly reduced within a week (6-11% Of day 0 value on day 8) and it remained low at least 6 months (14-18% on day 180). Follow-up of a higher dose 3 day regimen taken while fasting showed microfilaridermia of 7-9% of the day 0 value 2 years after treatment.
authors.affiliation: Ciba-Geigy Limited, Switzerland.
authors.forename: A A
authors.initials: AA
authors.lastname: Poltera
authors.forename: G
authors.initials: G
authors.lastname: Zea-Flores
authors.forename: R
authors.initials: R
authors.lastname: Guderian
authors.forename: F
authors.initials: F
authors.lastname: Beltranena
authors.forename: R
authors.initials: R
authors.lastname: Proana
authors.forename: M
authors.initials: M
authors.lastname: Moran
authors.forename: F
authors.initials: F
authors.lastname: Zak
authors.forename: H P
authors.initials: HP
authors.lastname: Striebel
mesh_terms: D000328:Adult; D000818:Animals; D015331:Cohort Studies; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004484:Ecuador; D005260:Female; D005369:Filaricides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006166:Guatemala; D006801:Humans; D009854:Onchocerca / Q000187:drug effects*; D009855:Onchocerciasis / Q000188:drug therapy* / Q000601:surgery; D010865:Pilot Projects; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012867:Skin / Q000469:parasitology
chemical_list: D005369:Filaricides; D010879:Piperazines; C051744:amocarzine