title: [Influence of verapamil and diltiazem on the muscle-relaxing effect of atracurium in vivo].
abstract: The interaction between atracurium and the two calcium antagonists verapamil and diltiazem were studied in rabbits. It was observed that intravenous verapamil (0.2 mg/kg) reduced by 25% and 30% respectively, the dose of atracurium required to produce a 50% or 95% of neuromuscular blockade. In contrast, intravenous diltiazem (1 mg/kg) failed to produce significant changes.
authors.affiliation: Departamento de Farmacología, Hospital de Galdakao.
authors.forename: E
authors.initials: E
authors.lastname: Gómez Iglesias
authors.forename: E
authors.initials: E
authors.lastname: García Pascual
authors.forename: C
authors.initials: C
authors.lastname: Aguirre Gómez
authors.forename: J M
authors.initials: JM
authors.lastname: Rodríguez-Sasiaín
authors.forename: R
authors.initials: R
authors.lastname: Calvo Duo
mesh_terms: D000818:Animals; D001279:Atracurium / Q000008:administration & dosage / Q000494:pharmacology*; D004110:Diltiazem / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D009126:Muscle Relaxation / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014700:Verapamil / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D011978:Receptors, Nicotinic; D001279:Atracurium; D014700:Verapamil; D004110:Diltiazem
vernacular_title: Influencia de verapamilo y diltiazem sobre el efecto relajante muscular del atracurio in vivo.