[Effect of environmental factors on the development of clinical polymorphism of familial schizophrenia].
In children, (group I, or probands) schizophrenia runs a more severe course than in parents (group II). This is supported by the presence in the group I patients of more remarkable characterological features, higher incidence and grade of the intensity of productive symptomatology at the premanifest stage of the disease, by more pronounced negative disorders and much worse social adaptation as compared to the group II patients. The educational level, living conditions and living together with the relatives do not exert any material effect on the intensity of the clinico-psychopathological manifestations. Meanwhile the lack of the family and work (completely or in speciality) may play a significant role in the negative dynamics of the disease and augmentation of the negative manifestations in schizophrenia in probands as compared to parents.
Zharikov
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D000328:Adult; D000367:Age Factors; D002648:Child; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000209:etiology / Q000235:genetics*; D012917:Social Adjustment; D012959:Socioeconomic Factors
Vliianie faktorov vneshneĭ sredy na formirovanie klinicheskogo polimorfizma semeĭnoĭ shizofrenii.