[Clonal origin of intrahepatic recurrence after resection of hepatocellular carcinoma].
Using integrated hepatitis B virus (HBV) DNA in the cancer cells as a genetic marker, clonal origin of intrahepatic recurrence of hepatocellular carcinoma was studied by Southern blot technique. Comparing 5 cases of postoperative recurrent hepatocellular carcinoma with their primary tumors, it was found that 1 case had identical HBV DNA integration patterns, 3 cases were of different clonality and 1 case with multiple nodular recurrences contained either a unicentric origin or a new distinctive clone origin. The results suggest that, in addition to recurrence from residual cancer cells, in some cases, hepatocellular carcinoma may develop repeatedly during a continuous process of carcinogen action, even after a radical resection.
Liang
X H
XH
Liver Cancer Institute, Shanghai Medical College.
D015139:Blotting, Southern; D006528:Carcinoma, Hepatocellular / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D004279:DNA, Viral / Q000032:analysis*; D006515:Hepatitis B virus; D006801:Humans; D008113:Liver Neoplasms / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000209:etiology*
D004279:DNA, Viral