title: Identification of alpha 2 adrenoceptors in the blood vessels of the dental pulp.
abstract: Using selective agonists and antagonists of alpha2 adrenoceptors, attempts were made to identify the subtype alpha2 adrenoceptors in the blood vessels of the canine dental pulp. In chloralose-anaesthetized dogs, intra-arterial administration of noradrenaline and guanabenz in different doses produced a dose-related pulpal vasoconstriction which was measured using hydrogen-gas clearance. The vasoconstrictor response to noradrenaline was inhibited by phentolamine, a non-selective alpha adrenoceptor antagonist. The response to guanabenz was inhibited by rauwolscine, a highly selective alpha2 adrenoceptor antagonist. The results demonstrated that alpha2 adrenoceptors are present in the blood vessels of dog dental pulp.
authors.affiliation: Department of Pedodontics, Medical Faculty, Bergen, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Ibricevic
authors.forename: K J
authors.initials: KJ
authors.lastname: Heyeraas
authors.forename: E
authors.initials: E
authors.lastname: Pasic Juhas
authors.forename: M
authors.initials: M
authors.lastname: Hamamdzic
authors.forename: N
authors.initials: N
authors.lastname: Djordjevic
authors.forename: J
authors.initials: J
authors.lastname: Krnic
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002339:Carotid Arteries; D003782:Dental Pulp / Q000098:blood supply*; D004285:Dogs; D005260:Female; D006143:Guanabenz / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000294:innervation*; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha; D014661:Vasoconstriction; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D011942:Receptors, Adrenergic, alpha; D015016:Yohimbine; D006143:Guanabenz; D009638:Norepinephrine; D010646:Phentolamine