[The effect of DMCM and diazepam on the behavior of rats subjected to ethanol exposure in the prenatal period].
White rats were given 4 g/lag daily of 40% ethyl alcohol from the 5th till the 20th day of pregnancy. Males of the off-spring from the 5th till 19th day were subjected to treatment with 0.6 mg/kg DMCM (4-ethyl-6, 7-dimethoxy-beta-carboline-3-carboxylate methyl ether) or 2.5 mg/kg of diazepam daily. It has been shown that both drugs normalize increased locomotor activity; treatment with DMCM corrects passive avoidance conditioned reflex retention; both drugs restore active avoidance conditioned reflex elaboration in rats alcoholized prenatally. Moreover, treatment with DMCM or diazepam restores correlations between behaviour indices and binding of 3H-diazepam which have been altered by prenatal alcoholization.
Kruglikov
R I
RI
Zhulin
V V
VV
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002243:Carbolines / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003292:Convulsants / Q000494:pharmacology*; D003975:Diazepam / Q000493:pharmacokinetics / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism
D002243:Carbolines; D003292:Convulsants; D011963:Receptors, GABA-A; C034818:methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate; D000431:Ethanol; D003975:Diazepam
Vliianie DMSM i diazepama na povedenie krys, podvergshikhsia vozdeĭstviiu étanola v prenatal'nom periode.