Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization.
Seventy-one human x mouse hybrid cell lines were used to map the locus of a human alpha-3-fucosyltransferase to 11q. The enzyme transfers fucose onto H type 2 more efficiently than onto sialyl-N-acetyllactosamine, suggesting that it is the myeloid type of alpha-3-fucosyltransferase (Mollicone et al., 1990), which makes the 3-fucosyllactosamine epitope on polymorphonuclear cells and monocytes. This epitope is also known as CD15 (Tetteroo et al., 1987).
Couillin
P
P
CNRS, Biochimie, Faculté de Pharmacie, Châtenay-Malabry, France.
Mollicone
R
R
Grisard
M C
MC
Gibaud
A
A
Ravisé
N
N
Feingold
J
J
Oriol
R
R
D000818:Animals; D000943:Antigens, Differentiation / Q000096:biosynthesis; D015139:Blotting, Southern; D002240:Carbohydrate Sequence; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D005647:Fucosyltransferases / Q000235:genetics*; D006801:Humans; D006822:Hybrid Cells; D016256:Lewis X Antigen; D051379:Mice; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization
D000943:Antigens, Differentiation; D016256:Lewis X Antigen; D005647:Fucosyltransferases; C031692:galactoside 3-fucosyltransferase