title: Elimination of type D retrovirus infection from group-housed rhesus monkeys using serial testing and removal.
abstract: Type D retrovirus was successfully eliminated from an infected population of group-housed rhesus monkeys by serial testing of all animals for virus and antibody and subsequent removal of positives. This population of 53 rhesus had been housed together for 1 year prior to the initiation of the test and removal program, with six deaths from type D retrovirus-induced immunodeficiency disease occurring during this period. No new infections were detected after four rounds of testing. Of the 47 animals present at the start of the testing program, 17 (35%) remained after the elimination of type D virus from this group. These animals and their offspring have remained healthy and antibody negative for more than 2 years. These results demonstrate that elimination of type D retroviruses from rhesus macaque colonies is feasible, and that the objective of establishing and maintaining retrovirus-free colonies is realistic and achievable.
authors.affiliation: California Primate Research Center, University of California, Davis 95616.
authors.forename: N W
authors.initials: NW
authors.lastname: Lerche
authors.forename: P A
authors.initials: PA
authors.lastname: Marx
authors.forename: M B
authors.initials: MB
authors.lastname: Gardner
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006799:Housing, Animal; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000175:diagnosis* / Q000517:prevention & control; D011790:Quarantine; D015301:Retroviruses, Simian / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000175:diagnosis* / Q000517:prevention & control / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral