title: Cytotoxicity of transferrin-daunorubicin conjugates on small cell carcinoma of the lung (SCCL) cell line NCI-H69.
abstract: We have evaluated the effectiveness of daunorubicin against an SCCL cell line (NCI-H69) after conjugation to transferrin. Our results show that the conjugate is at least 10 times more active than the free drug in this in vitro system.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Université Laval, Québec, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Béjaoui
authors.forename: M
authors.initials: M
authors.lastname: Pagé
authors.forename: C
authors.initials: C
authors.lastname: Nöel
mesh_terms: D018288:Carcinoma, Small Cell / Q000737:chemistry / Q000188:drug therapy*; D003630:Daunorubicin / Q000494:pharmacology*; D004338:Drug Combinations; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry / Q000188:drug therapy*; D011990:Receptors, Transferrin / Q000032:analysis; D014168:Transferrin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D004338:Drug Combinations; D011990:Receptors, Transferrin; D014168:Transferrin; D003630:Daunorubicin