Cyclic AMP and adaptive supersensitivity in guinea pig atria.
Supersensitivity was induced by injection of guinea pigs with reserpine, 0.1 mg/kg/day for 7 days. This treatment induced chronotropic supersensitivity of isolated right atria to isoproterenol but not to forskolin. The pretreatment induced supersensitivity to the cyclic AMP-generating effects of isoproterenol or forskolin in left, but not right, atria. These results are discussed in reference to the extensive literature describing supersensitivity in the guinea-pig heart, including the possible role of the adenylyl cyclase system.
Fleming
W W
WW
Department of Pharmacology and Toxicology, West Virginia University, Morgantown.
Taylor
D A
DA
D000818:Animals; D016275:Atrial Function; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D012016:Reference Values; D012110:Reserpine / Q000494:pharmacology*
D005576:Colforsin; D012110:Reserpine; D000242:Cyclic AMP; D007545:Isoproterenol