title: Suppression of interleukin-2 production and activity by factor(s) released by peripheral blood mononuclear cells during papillomavirus infections.
abstract: Supernatant fluids from cultured peripheral blood mononuclear cells (PBMC) obtained from patients with extensive papillomavirus infections such as condyloma acuminatum (CA) and epidermodysplasia verruciformis (EV) depressed the proliferative responses of T cells to phytohemagglutinin-P (PHA-P) and the production of interleukin-2 (IL-2) from those preparations. Fluids from the same cultures also inhibited the mitogenic activity of IL-2 on CTLL-2 cells as IL-2-dependent target cells. These soluble suppressor factors (SSF) from PBMC were present in significantly higher concentrations in fluids from cultured PBMC from patients in comparison to healthy controls. A soluble suppressor factor was characterized also from cultured rabbit PBMC after the rabbits had been infected with Shope papillomaviruses. This suppressor factor likewise inhibited IL-2 production and IL-2 activity.
authors.affiliation: Department of Microbiology, University of Texas Medical Branch Galveston 77550.
authors.forename: V
authors.initials: V
authors.lastname: Chopra
authors.forename: S K
authors.initials: SK
authors.lastname: Tyring
mesh_terms: D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D003218:Condylomata Acuminata / Q000097:blood / Q000150:complications / Q000276:immunology; D012777:Cottontail rabbit papillomavirus; D003864:Depression, Chemical; D004819:Epidermodysplasia Verruciformis / Q000097:blood / Q000150:complications / Q000276:immunology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000209:etiology; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D027383:Papillomaviridae; D011817:Rabbits; D013491:Suppressor Factors, Immunologic / Q000378:metabolism* / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects; D014412:Tumor Virus Infections / Q000097:blood* / Q000150:complications / Q000276:immunology
chemical_list: D007376:Interleukin-2; D013491:Suppressor Factors, Immunologic