Antiviral properties of 4-amino-(D3)-trishomocubanes.
Two amino derivatives of (D3)-Trishomocubanes recently synthesized were evaluated for their in vivo and in vitro activities against selected viruses. Both these derivatives exhibited promising in vivo activity against Herpes simplex Type II and Influenza A2/Taiwan, comparable with aciclovir and amantadine, respectively. No in vitro activity was observed for both compounds against Herpes simplex Types I and II and Rhinovirus 1A.
Oliver
D W
DW
Department of Pharmaceutical Chemistry, Pretoria College of Pharmacy, University of Pretoria, Republic of South Africa.
Dekker
T G
TG
Snyckers
F O
FO
D000212:Acyclovir / Q000494:pharmacology; D000547:Amantadine / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000494:pharmacology*; D005260:Female; D006558:Herpes Genitalis / Q000382:microbiology; D009980:Influenza A virus / Q000187:drug effects; D051379:Mice; D012229:Rhinovirus / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D014740:Vidarabine / Q000494:pharmacology; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; C070901:4-aminotrishomocubane; D000547:Amantadine; D014740:Vidarabine; D000212:Acyclovir