Effect of psychotomimetics and some putative anxiolytics on stress-induced hyperthermia.
Stress-induced hyperthermia (SIH), which is seen in the last mice removed from the cage, is a novel animal model sensitive to anxiolytic drugs. SIH is antagonized by CL 218872 (25 and 50 mg/kg, os), by tracazolate (5 and 7.5 mg/kg, ip) and by 2-AP-5 (50 and 100 mg/kg, ip). At higher dose, CL 218872 (100 mg/kg, os) and tracazolate (12.5 mg/kg, ip) lose their activity. PK 9084 (5-40 mg/kg, ip) and CGS 9896 (2-20 mg/kg, both ip and os) were also ineffective in preventing SIH. The anti-hyperthermic effect of CL 218872 (25 mg/kg) and tracazolate (7.5 mg/kg) was blocked by the benzodiazepine antagonist Ro 15-1788 (15 mg/kg), CGS 9896 (10 mg/kg, os) also reversed the effect of CL 218872 (25 mg/kg) on SIH. Differently from anxiolytics, MK-801 (0.5-1 mg/kg, os), PCP (2.5 mg/kg, ip) and d-amphetamine (10 mg/kg, ip) evoked hyperthermia in the first set of mice and prevented a further stress-induced rise of body temperature in the last set of mice.
Lecci
A
A
Pharmacological Research Department, A. Menarini Pharmaceuticals, Firenze, Italy.
Borsini
F
F
Gragnani
L
L
Volterra
G
G
Meli
A
A
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D005334:Fever / Q000209:etiology / Q000517:prevention & control*; D005442:Flumazenil / Q000494:pharmacology; D008297:Male; D051379:Mice; D010622:Phencyclidine / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D011724:Pyridazines / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D016037:Single-Blind Method; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*
D014151:Anti-Anxiety Agents; D011720:Pyrazoles; D011724:Pyridazines; D011804:Quinolines; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; D005442:Flumazenil; C021604:CL 218872; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate; C030079:PK 9084; C034704:2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3H)-one; D010622:Phencyclidine; D003913:Dextroamphetamine