Propranolol effect on GABA synthesis rate estimated by two different methods.
The propranolol effect on GABA synthesis rate in some brain structures using two different method was assessed. Both methods gave comparable results. Evaluation of the synthesis rate in vivo after inhibition of GABA degradation supplied more adequate information indicating that the availability of GABA precursor in the hypothalamus and the hippocampus is limited.
Jastrzebski
Z
Z
Department of Pharmacology, Institute of Drug Research and Control, Warsaw, Poland.
Remiszewska
M
M
Czyzewska-Szafran
H
H
Wutkiewicz
M
M
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D005680:gamma-Aminobutyric Acid; D011433:Propranolol