The influence of excipients and technological process on cholecalciferol stability and its liberation from tablets.
The influence of excipients, used in tablet technology, and technological processes on cholecalciferol (1) stability was investigated. It was observed that 1 degrades in the presence of some excipients. The stability of 1 may be increased by antioxidant addition. The best stabilizing effect was achieved by a alpha-tocopherol and ascorbic acid mixture. On the basis of the achieved results, tablets with 1 were prepared. Their physical and chemical properties, the content of 1, its stability and its pharmaceutical availability were determined.
Sawicka
J
J
Department of Pharmaceutical Technology, Medical Academy, Poznań, Poland.
D000975:Antioxidants; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002762:Cholecalciferol / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics; D004355:Drug Stability; D005079:Excipients; D008277:Magnesium Oxide; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical
D000975:Antioxidants; D005079:Excipients; D013607:Tablets; D002762:Cholecalciferol; D008277:Magnesium Oxide