title: [Epstein-Barr-virus-induced lymphoproliferative diseases].
abstract: Infections with EBV are of increasing importance in pediatrics. Molecular and immunological methods have led to important advances in our understanding of the biological properties of this virus and the immunological consequences to its host. EBV-associated lymphoproliferative disorders mainly arise in immunodeficient patients by the unchecked polyclonal outgrowth of EBV-infected B-cells. On the other hand, primary genetic changes in B-cells (chromosomal translocation and oncogene deregulation) may also lead to induction of monoclonal lymphoma.
authors.affiliation: Kinderklinik, Universität Würzburg.
authors.forename: V
authors.initials: V
authors.lastname: Schuster
authors.forename: H W
authors.initials: HW
authors.lastname: Kreth
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000382:microbiology; D002051:Burkitt Lymphoma / Q000382:microbiology; D002648:Child; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000382:microbiology; D007244:Infectious Mononucleosis / Q000382:microbiology; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000382:microbiology; D014181:Transplantation Immunology
vernacular_title: Epstein-Barr-Virus-induzierte lymphoproliferative Erkrankungen.