Growth factors and their receptors in metastasis.
The process of metastasis is not random. Rather, the outcome depends on the interaction of unique metastic cells with different organ microenvironments. Although the ability of some tumor cells to reach and proliferate in the parenchyma of some organs is responsible for the development of site-specific metastasis, the molecular basis of organ-specific metastasis is unclear. This article will address the molecular mechanisms involved in the interaction between favored tumor cells and a compatible organ environment in terms of growth factors and those receptors participating in paracrine and autocrine signal transduction pathways.
Radinsky
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Department of Cell Biology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
D000818:Animals; D004815:Epidermal Growth Factor / Q000502:physiology; D066246:ErbB Receptors / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D010982:Platelet-Derived Growth Factor / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D017468:Receptors, Fibroblast Growth Factor; D017479:Receptors, Platelet-Derived Growth Factor; D017451:Receptors, Somatomedin; D015398:Signal Transduction / Q000502:physiology; D013002:Somatomedins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D017451:Receptors, Somatomedin; D013002:Somatomedins; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D011972:Receptor, Insulin; D017479:Receptors, Platelet-Derived Growth Factor