Synthetic studies toward 9-keto-cannabinoids.
9-Keto-cannabinoid methyl ether, the precursor for many cannabinoid metabolites and analogues, was prepared from (+)-apoverbenone in 5 steps. This synthesis includes the condensation of apoverbenone with aryllithium followed by oxidation, hydrolysis of the MOM ether, acid-catalyzed cyclization, and metal ammonia reduction.
Wu
M J
MJ
School of Chemistry, Kaohsiung Medical College, Taiwan, Republic of China.
Huffman
J W
JW
D013759:Dronabinol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008722:Methods
C070153:9-keto-cannabinoid methyl ether; D013759:Dronabinol