[Dangerous hypoprothrombinemic hemorrhage in antibiotic therapy].
Antibiotics can be associated with hypoprothrombinaemic haemorrhages in risk patients. Risk factors are: poor nutrition, impaired liver- or renal function, coagulation depleting medical therapy or illness. Pathogenetically there is a vitamin K deficiency with reduction of vitamin K dependent clotting factors; mainly by decreased vitamin K synthesis in intestinal bacterias. In consequence every risk patient under antibiotics should receive vitamin K prophylactically and in a parenteral way, because of unreliable resorption in gastrointestinal tract. Prothrombin-time-monitoring is essential to recognize the hypoprothrombinemia in every risk patient under antibiotics.
Stieger
R
R
Chirurgische Abteilung, Kreisspital Bülach.
Baumgartner
K
K
Neff
U
U
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001064:Appendicitis / Q000601:surgery*; D002435:Cefamandole / Q000008:administration & dosage / Q000009:adverse effects; D004239:Diverticulitis, Colonic / Q000601:surgery*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced*; D007416:Intestinal Perforation / Q000601:surgery*; D008297:Male; D009950:Ornidazole / Q000008:administration & dosage / Q000009:adverse effects; D011183:Postoperative Complications / Q000139:chemically induced*; D011292:Premedication
D000900:Anti-Bacterial Agents; D002435:Cefamandole; D009950:Ornidazole
Gefährliche hypoprothrombinämische Blutungen unter Antibiotikatherapie.