The effect of Hoe-427 (an ACTH4-9 analog) on free-choice ethanol consumption in male and female rats.
Ethanol consummatory patterns of individual male and female rats and the effects of Hoe-427 (Ebiratide), an ACTH4-9 analog, thereon, were studied in a test system using 24 hour, two-bottle free choice consumption between 0.2% saccharin and 10% ethanol in 0.2% saccharin. Single, daily i.p. doses (0.03mg/rat) of either ACTH4-10 or its analog resulted in a significant reduction of daily ethanol consumption with no effects on saccharin consumption. After 4 days of treatment, male rats consistently exhibited a rebound increase in ethanol consumption; this effect was not seen in females. The daily ethanol consummatory patterns of the female animals seemed to exhibit a 4-6 day cyclic rhythymicity, suggesting an interaction with estrous cycles. These results support a role for ACTH4-10 in the initiation of ethanol consummatory behavior in rats and suggests the existence of sex differences in this phenomenon.
Krishnan
S
S
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1334.
Maickel
R P
RP
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology; D000428:Alcohol Drinking; D000818:Animals; D004334:Drug Administration Schedule; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology*; D010507:Periodicity; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin / Q000494:pharmacology; D012727:Sex Characteristics
D010446:Peptide Fragments; D000431:Ethanol; D000324:Adrenocorticotropic Hormone; C057139:ebiratide; D012439:Saccharin