Effects of buspirone on the immunosuppressive response to stress in mice.
Mice exposed to a chronic auditory stressor and treated with buspirone (1 mg/kg/day) showed a reduction in stress-induced suppression of thymus and spleen cellularity, and in peripheral T-lymphocyte population. The blastic response of spleen lymphoid cells was also assessed and buspirone was found to partially suppress the inhibitory effect of stress.
Freire-Garabal
M
M
Department of Pharmacology, School of Medicine, University of Santiago de Compostela, Spain.
Belmonte
A
A
Suárez-Quintanilla
J
J
D000161:Acoustic Stimulation; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
D003208:Concanavalin A; D000324:Adrenocorticotropic Hormone; D002065:Buspirone