A mathematical model describing the generation of oxygen radicals in mitochondria during ischemia-reperfusion.
A mathematical model for the generation of free radicals by mitochondria in ischemia-reperfusion is proposed. Computations show that normally two stable equilibrium states exist: the intact state, and the state characterized by damage to mitochondrial structures and a high rate of radical formation. Transition from one state to another occurs after hypoxia of a certain degree of severity and duration. The model also describes a number of phenomena observed during development of reperfusion injuries and drug therapy.
Volk
S E
SE
Department of Protein Chemistry, Belozerskii Institute of Physicochemical Biology, Moscow State University, Russia.
Zhilyaev
A M
AM
D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008954:Models, Biological; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
D005609:Free Radicals; D013481:Superoxides