[Regeneration of the function of the hypophyseal-gonadal system after its prolonged suppression with luliberin agonists].
The paper is concerned with the results of investigation into the nature of regeneration of function of the hypophyseo-gonadal system in 15 mature male Papio hamadryas, subjected to infusion of LH-RH agonists (buserelin, Hoechst A. G. Germany) and surfagon (All-Union Cardiology Research Center, USSR) using osmotic mini-pumps (Alzo Corp., Palo Alto, USA) for 5-16 weeks. Regeneration of this system was characterized by 3 main phases: latent; gonadal hyperfunction and return to the basal level of functioning. The time of phases was determined by a period of administration of the drug and individual features of functioning of the hypothalamo-hypophyseo-gonadal system. Unlike the sex glands, regeneration of hypophyseal gonadotropic function did not undergo the stage of hyperfunction but included the development of 2 phases of refractivity of gonadotropocytes to exogenous LH-RH, differing in the level of functional activity. Regeneration of function of the hypophyseo-gonadal system under basal conditions was followed by regeneration of a reaction of this system under the conditions of its activation.
Goncharova
N D
ND
Mkhitarova
L A
LA
Gogiladze
E M
EM
D000818:Animals; D002064:Buserelin / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010215:Papio; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology*; D011966:Receptors, LHRH / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000097:blood; D013997:Time Factors
D006728:Hormones; D011966:Receptors, LHRH; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C010661:surfagon; D007986:Luteinizing Hormone; D002064:Buserelin
Vosstanovlenie funktsii sistemy gipofiz-gonady posle ee dlitel'nogo podavleniia agonistami liuliberina.