title: Cloning and chromosomal localization of a human endothelin ETA receptor.
abstract: A cDNA clone encoding a human endothelin receptor was isolated from a placenta cDNA library. The deduced amino acid sequence of the clone is 94% identical to the bovine endothelin ETA receptor and represents the human homologue. The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids.
authors.affiliation: Department of Pharmacology, New York University Medical Center, New York 10016.
authors.forename: C
authors.initials: C
authors.lastname: Cyr
authors.forename: K
authors.initials: K
authors.lastname: Huebner
authors.forename: T
authors.initials: T
authors.lastname: Druck
authors.forename: R
authors.initials: R
authors.lastname: Kris
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D003001:Cloning, Molecular / Q000379:methods; D016232:Endothelins / Q000378:metabolism; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D008969:Molecular Sequence Data; D010957:Plasmids; D016133:Polymerase Chain Reaction; D051381:Rats; D011956:Receptors, Cell Surface / Q000235:genetics*; D017466:Receptors, Endothelin; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D016232:Endothelins; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin