[V-erbA oncogene, model of oncogenic activation of hormone receptor].
The identification of the viral oncogene v-erbA carried by an avian leukemia retrovirus has directly demonstrated the involvement of hormone receptors in neoplastic transformation. v-erbA represents an altered form of a nuclear receptor of the thyroid hormone T3. It blocks the differentiation of chicken erythrocyte progenitor cells and contributes to sarcoma transformation in association with other oncogenes. The protein encoded by v-erbA behaves as an antagonist against the normal T3 receptors and retinoic acid receptors. The primary effects of the protein result in altering the transcription of genes normally under control of the intact receptors. Presumably among these target genes are to be found genes which control cell differentiation and proliferation.
Samarut
J
J
Laboratoire de Biologie Moléculaire et Cellulaire, CNRS UMR49, INRA, Ecole Normale Supérieure de Lyon.
D000818:Animals; D001354:Avian Leukosis Virus; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D008957:Models, Genetic; D009856:Oncogene Proteins, Viral / Q000502:physiology*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D012097:Repressor Proteins / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D009856:Oncogene Proteins, Viral; D011988:Receptors, Thyroid Hormone; D012097:Repressor Proteins
L'oncogène v-erbA, modèle d'activation oncogénique d'un récepteur hormonal.