title: Ca(2+)-storage organelles.
abstract: Intracellular Ca(2+)-storage organelles are found in virtually all eukaryotic cells. They play an important role in the regulation of the cytosolic free Ca2+ concentration and, thereby, in the regulation of cellular activity. Ca(2+)-storage organelles consist, in the simplest model of a Ca2+ pump, of a Ca(2+)-storage protein and a Ca(2+)-release channel. The primary structure of these functionally important proteins of Ca(2+)-storage organelles is similar in different cell types and conserved through evolution. In contrast, their spatial arrangement and, thus, the architecture of Ca(2+)-storage organelles may vary dramatically from one cell type to another.
authors.affiliation: Department of Internal Medicine, University Hospital, Geneva, Switzerland.
authors.forename: K H
authors.initials: KH
authors.lastname: Krause
mesh_terms: D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D037282:Calreticulin; D002155:Calsequestrin / Q000378:metabolism; D004721:Endoplasmic Reticulum; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum
chemical_list: D015220:Calcium Channels; D002135:Calcium-Binding Proteins; D037282:Calreticulin; D002155:Calsequestrin; D002118:Calcium