[The relationship of biochemical changes among bronchoalveolar lavage fluid serum and lung on dust-exposed rats].
The relationship between biochemical changes in bronchoalveolar lavage fluid (BALF), serum and the lung of different dustexposed rats was studied. Wistar rats were divided into 5 groups: 1. Xingkong chrysotile asbestos (CH-As); 2. Dust in a sieve selection workshop of Xingkong asbestos mine (Dust-Wo); 3. Silica group (SiO2); 4. Titanium dioxide (TiO2) and 5. Normal control group (Control). All the rats were killed in three months after experiment. The results showed that the level of alveolar macrophages (AM), lactic dehydrogenase (LDH) and acid phosphatase (AcP) in each group was marked by related to collagen, lung fat, ceruloplasmin (Cp) and hydroxyproline (HoP) by r and t-test. Among the LDH from BALF, culture fluid and serum, there was also a marked relationship. So the authors pointed out that the BALF especially AM and LDH test could serve as a good and valuable index for detection the condition of pneumoconiosis.
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Zhang
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Jin
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D000818:Animals; D001194:Asbestos; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D004391:Dust / Q000009:adverse effects; D004781:Environmental Exposure / Q000009:adverse effects*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D008297:Male; D011650:Pulmonary Alveoli / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D012822:Silicon Dioxide
D004391:Dust; D001194:Asbestos; D012822:Silicon Dioxide; D003094:Collagen; D007770:L-Lactate Dehydrogenase