Derivatives of 2-mercaptobenzenesulphonamide. IX. Synthesis and some pharmacological properties of N- or S-dialkylaminoalkyl derivatives of 2-(4-chloro-2-mercapto-5-methylbenzenesulphonyl)guanidines.
Synthesis and results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system of 2-(4-chloro-2-mercapto-5-methylbenzenesulphonyl)guanidine hydrochloride derivatives containing N-dialkylaminoalkyl (V-VI, VIIb-VIIIb, Xa), or S-dialkylaminoalkyl (XI-XIII) groups, were described. Compounds VIIa-VIIIa, IX-X, XIa were isolated as free bases.
Brzozowski
Z
Z
Department of Drug Technology, School of Medicine, Gdańsk, Poland.
Sławiński
J
J
Kosmala
M
M
Oledzka
K
K
Filczewski
M
M
Miłobedzka
J
J
Lewandowski
K
K
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight; D051381:Rats; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D006146:Guanidines; D013438:Sulfhydryl Compounds