Effect of phototherapy on 3H-imipramine binding sites in patients with SAD, non-SAD and in healthy controls.
The effect of incandescent light treatment on the density of 3H-imipramine binding sites (Bmax) was investigated in 17 patients with seasonal affective disorder, in eight patients with non-seasonal depression and in six healthy volunteers. A significant increase in mean Bmax value parallel to a marked improvement of the depressive symptoms was found only in patients with SAD. No effect was observed either on mean Bmax value or on clinical symptoms in patients with non-SAD and on mean Bmax value in healthy volunteers.
Szádóczky
E
E
Postgraduate Medical School Department of Psychiatry and Clinical Psychology, National Institute for Nervous and Mental Diseases, Budapest, Hungary.
Falus
A
A
Németh
A
A
Teszéri
G
G
Moussong-Kovács
E
E
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism / Q000528:radiation effects; D002352:Carrier Proteins; D003866:Depressive Disorder / Q000097:blood / Q000523:psychology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010789:Phototherapy; D011569:Psychiatric Status Rating Scales; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000502:physiology / Q000528:radiation effects*; D016574:Seasonal Affective Disorder / Q000097:blood / Q000523:psychology / Q000628:therapy*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine