On the voltage dependence of inactivation in the sodium channel of the squid giant axon.
Measurements of the macroscopic sodium current in the squid giant axon show that the inactivation gate carries around 1.3 units of electronic charge. The contrary evidence from single-channel studies is considered, and a modified series-parallel model of the sodium channel is proposed that might help to resolve the disagreement.
Keynes
R D
RD
Physiological Laboratory, University of Cambridge, U.K.
D000818:Animals; D001369:Axons / Q000378:metabolism*; D049832:Decapodiformes; D007700:Kinetics; D008564:Membrane Potentials; D008959:Models, Neurological; D015222:Sodium Channels / Q000378:metabolism*
D015222:Sodium Channels