[The treatment of severe psoriatic arthritis with methotrexate in a weekly "mini-pulse" dosage plan].
The paper reports on the authors' own experience on the effect of therapy with methotrexate (MTX) in 18 patients with invalidant psoriatic arthritis (PA). The therapeutic scheme was of the weekly "mini-pulse" type (three doses of 2.5 mg administered at 12-hour interval, with a gradual increase to 15 mg/week). The results were very good in 12 cases (66.6%), good in 3 cases (16.6%) and absent in other two cases (11.1%). These results and the data in the literature lead to the conclusion that MTX is a valuable therapeutic alternative for severe P.A. under the conditions of a correct surveillance with the observance of the contraindications.
Parasca
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Clinica Medicală II, Secţia Clinica de Reumatologie, I.M.F. Cluj-Napoca.
Boloşiu
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HD
Rus
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V
Duţu
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D000328:Adult; D015535:Arthritis, Psoriatic / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D012074:Remission Induction; D013997:Time Factors
D008727:Methotrexate
Tratamentul artritei psoriazice severe cu metotrexat în schema posologică "mini-pulse" săptămînal.