Phototoxic potential of quinolones.
The photohaemolytic potentials of the quinolones oxolinic acid, pipemidic acid, rosoxacin, norfloxacin, ciprofloxacin and M-193324 (synthesis intermediary) were evaluated and compared with the photohaemolysis induced by nalidixic acid. Quinolones with a piperazine group in position 7 (pipemidic acid, norfloxacin and ciprofloxacin) did not induce photohaemolysis. However, oxolinic acid, rosoxacin and M-193324 produced a concentration- and oxygen-dependent photohaemolysis. Ascorbic acid, histidine and thiourea inhibited the photohaemolysis induced by oxolinic acid, rosoxacin and M-193324, suggesting a photodynamic mechanism similar to that found with nalidixic acid. In addition, deuterium oxide increased the photohaemolysis induced by photohaemolytic quinolones, indicating that this process is mediated by singlet oxygen.
Cárdenas
A M
AM
Laboratorio de Fotobiologia y Fotoquimica, Facultad de Medicina, Universidad de Valparaiso, Chile.
Vargas
F
F
Fernández
E
E
Hidalgo
M E
ME
D001205:Ascorbic Acid / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects* / Q000528:radiation effects; D006639:Histidine / Q000494:pharmacology; D006801:Humans; D008027:Light; D010782:Photolysis; D015363:Quinolones / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000494:pharmacology
D015363:Quinolones; D011838:Radiation-Sensitizing Agents; D006639:Histidine; D013890:Thiourea; D001205:Ascorbic Acid