Chemotherapeutic effect of azithromycin and lasalocid on Cryptosporidium infection in mice.
Prednisolone-immunosuppressed mice (ICR, 7-wk-old female) were each inoculated with 1 x 10(5) oocysts of Cryptosporidium parvum. Medication with azithromycin (400 mg/kg/day) or lasalocid (64, or 128 mg/kg/day) was started 13 h after inoculation and continued for 3 days. The number of oocysts discharged by each mouse was calculated on days 4-12 post-inoculation. Compared with non-medicated controls, oocyst production by the medicated mice was markedly reduced; some mice did not discharge oocysts and the remaining mice discharged less than 1/100 the number of oocysts of the control mice. These results indicate that both azithromycin and lasalocid have prophylactic or therapeutic activity against Cryptosporidium.
Kimata
I
I
Department of Medical Zoology, Osaka City University Medical School, Japan.
Uni
S
S
Iseki
M
M
D000818:Animals; D017963:Azithromycin; D003049:Coccidiostats / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy*; D016785:Cryptosporidium parvum; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D016867:Immunocompromised Host; D007832:Lasalocid / Q000627:therapeutic use*; D051379:Mice; D008813:Mice, Inbred ICR; D010270:Parasite Egg Count; D013047:Specific Pathogen-Free Organisms
D003049:Coccidiostats; D004917:Erythromycin; D017963:Azithromycin; D007832:Lasalocid