title: HPLC and 1H-NMR study of chiral recognition in some thromboxane antagonists induced by beta-cyclodextrin.
abstract: The interaction of beta-cyclodextrin with a series of structurally related chiral thromboxane antagonists was investigated using NMR and RP-HPLC. HPLC studies used both a cyclodextrin bonded phase (Cyclobond I), and beta-cyclodextrin as a mobile phase additive with an achiral C8 column. Many of the compounds exhibited chiral recognition with beta-cyclodextrin in each technique, but only partial correlations between the three data sets were observed. HPLC and ROESY NMR data suggested the possibility of bimodal inclusion.
authors.affiliation: School of Pharmacy and Pharmacology, University of Bath, Claverton Down, UK.
authors.forename: A F
authors.initials: AF
authors.lastname: Casy
authors.forename: A D
authors.initials: AD
authors.lastname: Cooper
authors.forename: T M
authors.initials: TM
authors.lastname: Jefferies
authors.forename: R M
authors.initials: RM
authors.lastname: Gaskell
authors.forename: D
authors.initials: D
authors.lastname: Greatbanks
authors.forename: R
authors.initials: R
authors.lastname: Pickford
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011522:Protons; D013237:Stereoisomerism; D013931:Thromboxanes / Q000037:antagonists & inhibitors*; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D011522:Protons; D013931:Thromboxanes; D047392:beta-Cyclodextrins; C031215:betadex