Detection and cellular localization of lead by electron probe analysis in the diagnosis of suspected lead poisoning in rhesus monkeys.
Lead poisoning of unknown source was diagnosed histologically in 2 rhesus monkeys (Macaca mulatta) by finding acid-fast intranuclear inclusion bodies in the epithelial cells of renal cortical tubules. The presence of lead in the inclusions was determined by scanning electron microscopy/energy dispersive x-ray analysis using sections from paraffin embedded tissues. This observation indicates the usefulness of this technique for the detection and cellular localization of lead in tissues, even from archival material.
Sass
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B
Division of Cancer Etiology, National Cancer Institute, Bethesda, Maryland 20892.
Banfield
W G
WG
Saffiotti
U
U
D000818:Animals; D004577:Electron Probe Microanalysis; D005260:Female; D002479:Inclusion Bodies / Q000737:chemistry; D007854:Lead / Q000032:analysis*; D007855:Lead Poisoning / Q000175:diagnosis*; D008253:Macaca mulatta; D008855:Microscopy, Electron, Scanning
D007854:Lead