[Heparin-associated thrombocytopenia, thrombosis and embolism. Side effects of thromboembolism prevention with low molecular weight heparin enoxaparin?].
Heparin-associated thrombocytopenia (HAT) is a rarely described adverse reaction of systemic administration of heparin that may be complicated by thrombosis, embolism and bleeding. Unfractionated heparin as well as low molecular weight heparin may provoke HAT. A case of HAT complicated by thrombosis and pulmonary embolism is described that came about during preventive postoperative anticoagulation with the low molecular weight heparin enoxaparin. Pathogenesis, diagnosis, prophylaxis and therapy of HAT are discussed.
Mohr
V D
VD
Abteilung Chirurgie, Bundeswehrzentralkrankenhauses Koblenz.
Lenz
J
J
D000368:Aged; D001241:Aspirin / Q000008:administration & dosage; D001780:Blood Coagulation Tests; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000601:surgery; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000601:surgery; D008297:Male; D009392:Nephrectomy; D010644:Phenprocoumon / Q000008:administration & dosage; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count / Q000187:drug effects; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control*; D011655:Pulmonary Embolism / Q000097:blood / Q000139:chemically induced* / Q000517:prevention & control*; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced*; D013924:Thrombophlebitis / Q000097:blood / Q000139:chemically induced* / Q000517:prevention & control*
D006495:Heparin, Low-Molecular-Weight; D010644:Phenprocoumon; D001241:Aspirin
Heparin-assoziierte Thrombocytopenie, Thrombose und Embolie. Unerwünschte Wirkung der Thromboembolieprophylaxe mit dem niedermolekularen Heparin Enoxaparin?