Quantitative autoradiographic localisation of [125I]endothelin-1 binding sites in spinal cord and dorsal root ganglia of the rat.
The autoradiographic distribution of [125I] endothelin (ET)-1 binding sites was studied in the spinal cord and dorsal root ganglia of developing and adult rat. In the spinal cord, high density of [125I]ET-1 binding sites were diffusely distributed throughout the grey matter whereas in the ganglia discrete silver grains were localised primarily on the satellite cells. A variation in the density of binding sites was evident, particularly in the spinal cord, during development. These data, in conjunction with other reports, suggest a possible neuromodulatory role for ET-1 in spinal cord and dorsal root ganglia of the rat.
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Douglas Hospital Research Center, McGill University, Verdun, Que., Canada.
Chabot
J G
JG
Quirion
R
R
D000818:Animals; D001345:Autoradiography; D016232:Endothelins / Q000378:metabolism*; D005260:Female; D005727:Ganglia, Spinal / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D007457:Iodine Radioisotopes; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017466:Receptors, Endothelin; D013116:Spinal Cord / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*
D016232:Endothelins; D007457:Iodine Radioisotopes; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin