Iron loading modifies beta-adrenergic responsiveness in cultured ventricular myocytes.
Cultured cardiac myocytes are suitable for studying iron toxicity in the heart. Previous studies have shown that changes in lipid composition and cellular function occur in such cells. This preliminary note describes the decreased response to beta-adrenergic stimulation in iron-loaded cardiomyocytes in culture.
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Department of Nutrition, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Athias
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Grynberg
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Hershko
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Pinson
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D000818:Animals; D002478:Cells, Cultured; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007501:Iron / Q000633:toxicity*; D007545:Isoproterenol / Q000494:pharmacology; D009206:Myocardium / Q000166:cytology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
D011943:Receptors, Adrenergic, beta; D007501:Iron; D007545:Isoproterenol