title: New concepts in Parkinson's disease.
abstract: As research has focused on environmental factors toxic to dopaminergic neurons of the substantia nigra, new therapies have emerged. These include the first drugs that may prove to slow the progression of nigral cell death. Also under investigation is surgical therapy, specifically the implantation of fetal or genetically engineered cells to restore dopamine synthesis.
authors.affiliation: Neurology Residency Program, Cleveland Clinic Foundation.
authors.forename: P J
authors.initials: PJ
authors.lastname: Sweeney
mesh_terms: D000313:Adrenal Medulla / Q000637:transplantation; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004298:Dopamine / Q000096:biosynthesis / Q000378:metabolism*; D015259:Dopamine Agents / Q000627:therapeutic use; D006801:Humans; D020267:MPTP Poisoning; D008875:Middle Aged; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism / Q000601:surgery; D011954:Receptors, Dopamine / Q000187:drug effects
chemical_list: D015259:Dopamine Agents; D011954:Receptors, Dopamine; D004298:Dopamine