title: Magnesium supplementation as an adjuvant to synthetic calcium channel antagonists in the treatment of hypertension.
abstract: Magnesium (Mg2+) has antagonistic properties to calcium (Ca2+) and has been termed the physiologic Ca2+ blocker. Synthetic Ca2+ channel blockers are extensively used as anti-hypertensive agents. It is hypothesised that when administered in combination synthetic Ca2+ channel blockers and Mg are synergistic in the treatment of hypertension.
authors.affiliation: Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa.
authors.forename: R M
authors.initials: RM
authors.lastname: Touyz
mesh_terms: D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D015220:Calcium Channels / Q000502:physiology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008274:Magnesium / Q000627:therapeutic use*; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D008274:Magnesium