Epstein-Barr virus--a possible missing link in the initiation of cervical carcinogenesis?
Salient epidemiological and molecular biological features of Epstein-Barr virus (EBV) infection correlate well with the natural history of carcinoma of the cervix. It is therefore hypothesised that the incorporation of EBV into the genome of cervical epithelial cells at an early age (teens) could be an important early event in cervical carcinogenesis.
Wong
S Y
SY
Department of Pathology, National University of Singapore, National University Hospital.
Sewell
H F
HF
MacGregor
J E
JE
Walker
F
F
D005260:Female; D005814:Genes, Viral; D016259:Genes, myc; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D008954:Models, Biological; D016036:Seroepidemiologic Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology