Tumorigenicity of EBV-carrying lymphoblastoid cell lines (LCLs): distinctive grading in SCID mice.
The in vitro and in vivo growth of lymphoblastoid cell lines (LCLs), Burkitt lymphomas (BLs) and PBL-derived immunoblastomas in SCID mice was studied in parallel. Most, but not all, of the LCLs tested were tumorigenic in SCID mice. Long-term culturing in vitro was not a necessary prerequisite for tumorigenicity. There was a good correlation between in vivo and in vitro growth. Three major classes of cells could be distinguished on the basis of their growth properties.
Ramqvist
T
T
Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden.
Norén
L
L
Iwarsson
K
K
Klein
G
G
D000818:Animals; D002051:Burkitt Lymphoma / Q000382:microbiology / Q000473:pathology*; D002455:Cell Division; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008214:Lymphocytes; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000382:microbiology / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous