Assignment of a human serum glycoprotein SP-40,40 gene (CLI) to chromosome 8.
SP-40,40 is a serum glycoprotein consisting of two different subunits (alpha and beta) assembled into a dimer by disulfide bonds. Northern blot hybridization, using total RNA from several cell lines, showed that SP-40,40 is expressed in glioblastoma and testicular tumor cells, as well as hepatoma cells. Spot blot hybridization of flow-sorted human chromosomes, using a SP-40,40 cDNA fragment as a probe, localized the gene for SP-40,40 to human chromosome 8. This gene has been given the designation CLI, for complement lysis inhibitor, by the Human Gene Nomenclature Committee.
Tobe
T
T
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Minoshima
S
S
Yamase
S
S
Choi
N H
NH
Tomita
M
M
Shimizu
N
N
D001798:Blood Proteins / Q000235:genetics*; D015152:Blotting, Northern; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D051152:Clusterin; D005134:Eye Neoplasms / Q000235:genetics; D005434:Flow Cytometry; D015870:Gene Expression / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics; D008297:Male; D018832:Molecular Chaperones; D012175:Retinoblastoma / Q000235:genetics; D013736:Testicular Neoplasms / Q000235:genetics; D014407:Tumor Cells, Cultured
D001798:Blood Proteins; C495242:CLU protein, human; D051152:Clusterin; D006023:Glycoproteins; D018832:Molecular Chaperones