[Possibilities of therapeutic applications of neuronal calcium homeostasis].
The role of calcium as a second messenger which mediates the transmission of the signal and has an impact on cellular regulation of the majority of organs at all stages of development was confirmed during the past decade. In the submitted review the authors summarize mechanisms by which calcium exerts its regulatory function. At the same time the authors discuss the possible ratio of disorders in the above systems in various diseases in particular those of the central nervous system and possible pharmacotherapeutic interferences at different levels of transmission of the signal mediated by calcium. As in the mentioned area at the clinical level so far mainly calcium channel blockers were used, the authors summarize the use of these substances in the treatment of cerebral ischaemia, migraine, epilepsy and manic-depressive disease.
Dobrovský
K
K
Výzkumný ústav pro farmacii a biochemii, Praha.
Valchár
M
M
Höschl
C
C
D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D015220:Calcium Channels / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D015290:Second Messenger Systems
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002118:Calcium
Moznosti terapeutického vyuzití zásahu do neuronální kalciové homeostázy.