(-)-N,N'-but-2-ene-1,4-diylbimorphinans.
N,N'-But-2-ene-1,4-diylbimorphinans 1-3 have been synthesized and pharmacologically evaluated. Bimorphinans 1 and 3 show opioid antagonist activity and preference for mu and kappa opioid receptors in mouse vas deferens and guinea pig ileum preparations.
Schmidhammer
H
H
Institute of Organic and Pharmaceutical Chemistry, University of Innsbruck, Austria.
Smith
C F
CF
Dalkner
E
E
Erlach
D
D
Heuberger
M
M
Rollinger
J M
JM
D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009019:Morphinans / Q000138:chemical synthesis* / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000187:drug effects; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma; D014649:Vas Deferens / Q000187:drug effects
D009019:Morphinans; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D017450:Receptors, Opioid, mu; D017480:Receptors, sigma