Cytomegalovirus encephalitis in a non-immunocompromised patient: CSF diagnosis by in situ hybridization cells.
Cytomegalovirus (CMV) encephalitis in immunologically normal patients is rarely reported in the literature. CMV infection was diagnosed by viral DNA probe techniques on CSF cells in a 32-year-old, immunologically normal male presenting with a severe clinical picture due to encephalitis. Administration of ganciclovir was followed by an immediate improvement in the patient's condition. More sensitive techniques for CMV detection could allow to discover more cases of CMV encephalitis in non-immunocompromised patients than previously recognized.
Pantoni
L
L
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Inzitari
D
D
Colao
M G
MG
De Mayo
E
E
Marini
P
P
Mazzota
F
F
D000328:Adult; D002555:Cerebrospinal Fluid / Q000166:cytology*; D003586:Cytomegalovirus Infections / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000188:drug therapy; D015342:DNA Probes; D003937:Diagnosis, Differential; D004660:Encephalitis / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000188:drug therapy; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D008279:Magnetic Resonance Imaging; D008297:Male; D009460:Neurologic Examination
D015342:DNA Probes; D015774:Ganciclovir