Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.
The cyst form of Toxoplasma gondii has been implicated as a cause of recrudescence of the latent infection in congenitally infected patients and in the immunocompromised host. A method was developed to evaluate the effect of drugs on the cyst form of the parasite and used to evaluate a variety of therapeutic agents. The most active compounds against the cyst form in vitro were arprinocid-N-oxide, azithromycin, and the hydroxynaphthoquinone 566C80.
Huskinson-Mark
J
J
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301.
Araujo
F G
FG
Remington
J S
JS
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D053626:Atovaquone; D017963:Azithromycin; D001921:Brain / Q000469:parasitology; D002981:Clindamycin / Q000494:pharmacology; D003049:Coccidiostats / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D009285:Naphthoquinones / Q000494:pharmacology; D011739:Pyrimethamine / Q000494:pharmacology; D013411:Sulfadiazine / Q000494:pharmacology; D014122:Toxoplasma / Q000187:drug effects*
D000890:Anti-Infective Agents; D003049:Coccidiostats; D009285:Naphthoquinones; D013411:Sulfadiazine; D002981:Clindamycin; C027555:arprinocid-N-oxide; D004917:Erythromycin; D017963:Azithromycin; D000225:Adenine; D005472:Fluorouracil; D053626:Atovaquone; D011739:Pyrimethamine