[Experimental study on the relationship between burn shock and infection].
It is well known that burned patients with difficulty in passing through the shock stage are commonly complicated by early septicemia. But explanations about the mechanism vary and no one can account for all the cases. In the present study, Specific Pathogen-free mice (950), Germfree mice (50) and Wistar rats (720) were used in studying 25%-30% burn injury; limited time of hypotension; endotoxemia and simple intestinal obstruction to determine if the bacteria could translocate across the viable intestinal wall to cause systemic infection. The data showed that microflora from gut can cause systemic infection following early burn injury; and shock, endotoxemia and ileus which always complicate severe burns can function together in promoting bacteria translocation. These results suggest that gut origin infection may play an important role in irreversible burn shock and/or early fulminating septicemia following burn injury.
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D000818:Animals; D001424:Bacterial Infections / Q000209:etiology*; D002056:Burns / Q000150:complications*; D005260:Female; D007413:Intestinal Mucosa / Q000473:pathology; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D018805:Sepsis / Q000209:etiology; D012769:Shock / Q000150:complications*