Effects of enriched lactate solution (ELS) for resuscitation after burn injury.
Full skin thickness burns covering 35 per cent of the total body surface of rabbits were followed by measurements of Na-K ATPase and arterial blood gas analyses, before and after the burn injury. Studies of the effects of intravenous fluids with different compositions showed that the active transport of the cell membrane was depressed in vivo immediately after a burn injury, mainly due to acidosis. This phenomenon was not completely corrected by the Baxter formula which uses conventional lactated Ringer's solution. However, an improvement was observed in those groups given the 'Enriched Lactate Solution' (ELS) containing large quantities of lactate as the base source. These results suggest that ELS, which positively corrected acidosis in accordance with its concentration, is very effective and more appropriate than the conventional lactated Ringer's solution for early burn resuscitation.
Ono
I
I
Department of Dermatology, Fukushima Medical College, Japan.
Ohura
T
T
Sakamura
R
R
Murazumi
M
M
Sekido
M
M
Miyashita
M
M
Goto
M
M
Kato
S
S
Sumiya
S
S
D000138:Acidosis / Q000628:therapy; D000818:Animals; D001784:Blood Gas Analysis; D002056:Burns / Q000628:therapy*; D005440:Fluid Therapy; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage*; D007773:Lactates / Q000008:administration & dosage*; D011817:Rabbits; D012151:Resuscitation; D000077325:Ringer's Lactate; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis
D007552:Isotonic Solutions; D007773:Lactates; D000077325:Ringer's Lactate; D000254:Sodium-Potassium-Exchanging ATPase