Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins.
Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.
Kusano
A
A
School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
Nikaido
T
T
Kuge
T
T
Ohmoto
T
T
Delle Monache
G
G
Botta
B
B
Botta
M
M
Saitoh
T
T
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D003374:Coumarins / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006035:Glycyrrhiza; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
D003374:Coumarins; D005419:Flavonoids; D015105:3',5'-Cyclic-AMP Phosphodiesterases