Reduction of salbutamol-induced drinking by putative and proven antidepressants.
Salbutamol-induced drinking was determined in rats after 4 days of twice daily treatment with the conventional and putative antidepressants desipramine, clenbuterol or salbutamol. Drinking was also determined 21 h after a single dose of the abovementioned drugs. Both chronic and acute administration of the drugs resulted in a significant reduction in the salbutamol-induced fluid intake. The results suggest that these drugs decrease beta 2-adrenoceptor activity, but that repeated administration is not a prerequisite for the effect.
Gard
P R
PR
School of Pharmacy, Central Institute of Technology, Wellington, New Zealand.
Fawcett
J P
JP
Kerr
K P
KP
D000420:Albuterol / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002976:Clenbuterol / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology
D000928:Antidepressive Agents; D011943:Receptors, Adrenergic, beta; D000420:Albuterol; D003891:Desipramine; D002976:Clenbuterol