title: [Polyamine modulation of phosphorylation of channel-forming cytosolic protein in bovine brain].
abstract: Phosphorylation of the bovine brain TTX-sensitive cytosolic protein which is similar in several functional properties to the membrane potential-dependent sodium channel has been studied. The results obtained indicate that the cytosolic protein is a substrate for cAMP-dependent phosphorylation. Polyamines at a concentration of 5.0 mmol/l inhibit markedly phosphorylation of the cytosolic protein. Spermine is shown to be the most effective inhibitor. It is suggested that polyamines may modulate the cell sodium channel function.
authors.forename: T F
authors.initials: TF
authors.lastname: Kastrikina
authors.forename: M K
authors.initials: MK
authors.lastname: Malysheva
authors.forename: T M
authors.initials: TM
authors.lastname: Surgova
mesh_terms: D000818:Animals; D015317:Biogenic Polyamines / Q000502:physiology*; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D000242:Cyclic AMP / Q000502:physiology; D003600:Cytosol / Q000378:metabolism*; D008564:Membrane Potentials / Q000502:physiology; D010766:Phosphorylation; D011506:Proteins / Q000378:metabolism*; D015222:Sodium Channels / Q000502:physiology
chemical_list: D015317:Biogenic Polyamines; D011506:Proteins; D015222:Sodium Channels; D000242:Cyclic AMP
vernacular_title: Modulirovanie poliaminami fosforilirovaniia kanalformernogo tsitozol'nogo belka mozga byka.