Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis.
A dose of 75 mg of azithromycin per kg of body weight per day combined with a dose of 2 micrograms of gamma interferon per day and administered for 10 days protected at least 40% of mice infected with a lethal inoculum of Toxoplasma gondii. Azithromycin administered alone protected less than 10% of the mice; gamma interferon had no protective effect.
Araujo
F G
FG
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, Palo Alto, California 94301.
Remington
J S
JS
D000818:Animals; D017963:Azithromycin; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007371:Interferon-gamma / Q000494:pharmacology*; D051379:Mice; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D004917:Erythromycin; D007371:Interferon-gamma; D017963:Azithromycin