Physicochemical properties of signal receptor domains as the basis for sequence comparison.
1. An algorithm of sequence comparison based on average bulkiness of amino acids in protein domains and not requiring sequence alignment is described. 2. A complete evolutionary tree of the signal receptor proteins is built. The STE2 proteins are shown to belong to this family. 3. Factorial analysis of average bulkiness makes it possible to discriminate functional and intraspecies differences between proteins.
Berman
A L
AL
Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences, Leningrad, USSR.
Dityatev
A E
AE
Frishman
D I
DI
D000465:Algorithms; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D005075:Biological Evolution; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear; D051964:Receptors, Mating Factor; D018000:Receptors, Peptide; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D014157:Transcription Factors
D000596:Amino Acids; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D051964:Receptors, Mating Factor; D018000:Receptors, Peptide; D014157:Transcription Factors; C070300:cSTE2 protein, human; C070299:kSTE2 protein, human; C036318:signal peptide receptor; D019204:GTP-Binding Proteins