Long-lasting enhancement of the membrane-associated protein kinase C activity in the hippocampal kindled rat.
We demonstrated that only membrane-associated protein kinase C (PKC) activity increased in the bilateral hippocampus (HIPP) up to 4 weeks and in the amygdala/pyriform cortex (AM/PC) at 4 weeks after the last kindled seizure. The enhancement of the membrane-associated PKC activity exceeds the increase in the protein concentration, which was observed in part. The overwhelming increase in the PKC activity should be of significance in the long-term maintenance of the kindling phenomenon.
Daigen
A
A
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Akiyama
K
K
Itoh
T
T
Kohira
I
I
Sora
I
I
Morimoto
K
K
Otsuki
S
S
D000818:Animals; D001931:Brain Mapping; D003600:Cytosol / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D004827:Epilepsy / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology*; D007696:Kindling, Neurologic / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology*; D051381:Rats; D013570:Synaptic Membranes / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*
D011493:Protein Kinase C