The effect of tumor necrosis factor (TNF-alpha) on calcium (Ca2+) level.
Following addition TNF-alpha to variety of cells the diversity of action has been observed. TNF-alpha induced rapid elevation of intercellular Ca2+ level in all studied cells. This suggests TNF receptor is coupled to phospholipase C.
Miłoszewska
J
J
Dept. of Tumor Biology, Maria Skłodowska-Curie Institute of Oncology, Warsaw, Poland.
Janik
P
P
Ostrowski
J
J
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D010738:Type C Phospholipases / Q000378:metabolism
D011956:Receptors, Cell Surface; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D010738:Type C Phospholipases; D002118:Calcium