Increase in protein kinase-C-beta-like immunoreactivity (PKC-beta-LI) in the rat superior cervical ganglion after decentralization.
The effect of decentralization on protein kinase-C-beta-like immunoreactivity (PKC-beta-LI) in the rat superior cervical ganglion (SCG) was studied. The cervical sympathetic trunk was transected and at different time points (0 h-14 d) after transection the rats were decapitated and the SCGs examined immunohistochemically. In the control ganglia only faint PKC-beta-LI was seen in the principal neurons, whereas several strongly immunolabelled nerve fibers were observed. In the principal ganglionic neurons PKC-beta-LI was found to be increased 1-8 days after denervation, with the maximum accumulation occurring at 4 days. Fourteen days post-transection PKC-beta-LI in the neuronal perikarya was back to the initial level, but a decrease in the number of PKC-beta-immunoreactive nerve fibers was observed. The results suggest that the amount of PKC-beta in the principal neurons of the rat SCG may be partly regulated transsynaptically by preganglionic innervation.
Roivainen
R
R
Department of Public Health, University of Tampere, Finland.
D000818:Animals; D003655:Decerebrate State / Q000201:enzymology*; D004789:Enzyme Activation / Q000502:physiology; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000201:enzymology*; D008297:Male; D009474:Neurons / Q000201:enzymology; D011493:Protein Kinase C / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011493:Protein Kinase C