Motor activity and the GABAA-receptor in the ventral pallidum/substantia innominata complex.
The present study deals with the role of the gamma-aminobutyric acid-A (GABAA) receptor in motor activity in the rostral part of the ventral pallidum/substantia innominata complex. Both the specific GABAA antagonist bicuculline (25-100 ng/0.5 microliter) and the GABAA agonist muscimol (25 ng/0.5 microliter) enhanced motor activity. It was moreover found that bicuculline (50-100 ng) dose-dependently attenuated the activity induced by muscimol (25 ng). Conversely, muscimol (25 ng) attenuated the bicuculline (25-50 ng) induced activity. These data thus show that both stimulation and blockade of GABAA receptors within the area under study enhance motor activity.
van den Bos
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Psychoneuropharmacology Research Unit, Catholic University Nijmegen, The Netherlands.
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D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005917:Globus Pallidus / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D011963:Receptors, GABA-A; D009118:Muscimol; D001640:Bicuculline