The effect of morphine and DAGO on the proliferative response of murine splenocytes.
Morphine added in vitro to BALB/c mouse spleen cells inhibits mitogen responses. Naloxone and naltrexone, but not nor-BNI, antagonize the effect of morphine, suggesting that the kappa opioid receptor is not involved in in vitro immunomodulation of mitogen responses by morphine.
Eisenstein
T K
TK
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Taub
D D
DD
Adler
M W
MW
Rogers
T J
TJ
D000595:Amino Acid Sequence; D000818:Animals; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D004745:Enkephalins / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008934:Mitogens / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008969:Molecular Sequence Data; D009020:Morphine / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology; D011957:Receptors, Opioid / Q000187:drug effects; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D004745:Enkephalins; D008934:Mitogens; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009020:Morphine