title: Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats.
abstract: Injections of high doses of etorphine (0.0625, 0.25, or 1.0 mumol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.
authors.affiliation: Department of Psychology, University of Haifa, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Leshem
authors.forename: H
authors.initials: H
authors.lastname: Frenk
authors.forename: R C
authors.initials: RC
authors.lastname: Coghill
authors.forename: D J
authors.initials: DJ
authors.lastname: Mayer
mesh_terms: D000818:Animals; D005048:Etorphine / Q000008:administration & dosage / Q000494:pharmacology*; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010243:Paralysis / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*
chemical_list: D011957:Receptors, Opioid; D009270:Naloxone; D005048:Etorphine; D005283:Fentanyl