Induction of microsomal drug metabolizing enzymes by phenobarbitone in the rats exposed to increased environmental temperature.
Exposure of rats for 3 consecutive days (6 h a day) to 28 degrees C or 35 degrees C does not lead to changes in the induction of hepatic microsomal cytochrome P-450 associated monooxygenases by phenobarbitone as compared with control animals exposed to 21 degrees C. These results suggest that environmental temperature does not change the capacity of phenobarbitone to induce drug metabolizing enzymes in rat liver.
Pachecka
J
J
Department of Drug Metabolism, School of Medicine, Warsaw, Poland.
Kobylińska
K
K
Zasłona
H
H
Zagdańska
B
B
Bicz
W
W
D000818:Animals; D004781:Environmental Exposure; D004790:Enzyme Induction / Q000187:drug effects; D006361:Heating; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013696:Temperature
D006899:Mixed Function Oxygenases; D010634:Phenobarbital