[The central gray substance of the midbrain: the role of corticosteroids in the analgesic effect].
The effect of stimulation of periaqueductal gray matter on pain threshold and blood corticosteroids was studied in anesthetized rats. The stimulation with 30-50-microA current resulted in an increase of analgesia and blood corticosteroids. An increase of current intensity up to 100 microA resulted in a decreasing corticosteroid level and analgetic effect. The magnitude and duration of the analgesia were decreased after blocking the pituitary-adrenocortical system. The corticosteroids seem to induce analgesia after stimulation of periaqueductal gray matter stimulation.
Iarushkina
N I
NI
Bogdanov
A I
AI
Filaretov
A A
AA
D000305:Adrenal Cortex Hormones / Q000097:blood / Q000502:physiology*; D000698:Analgesia; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D010147:Pain Measurement; D010487:Periaqueductal Gray / Q000187:drug effects / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D000305:Adrenal Cortex Hormones; C021650:hydrocortisone acetate; D003345:Corticosterone; D006854:Hydrocortisone
Tsentral'noe seroe veshchestvo srednego mozga: rol' kortikosteroidov v obezbolivaiushchem éffekte.