title: Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.
abstract: The development of Wilms tumor (WT) has been associated with the inactivation of a "tumor suppressor" locus in human chromosome 11 band p13. Several WTs that exhibit homozygous deletions of an 11p13 candidate WT gene in its entirety have been reported. We report here a partial deletion of the candidate gene which, upon comparison with other documented homozygous deletions, permitted a precise definition of the critical genomic target in Wilms tumor. The smallest region of overlap between these deletions is a 16-kb segment of DNA encompassing the 5' exon(s) of an 11p13 gene coding for a zinc finger protein, together with an associated CpG island. This finding supports the notion that the candidate gene in question corresponds to the 11p13 WT1 Wilms tumor locus.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: C C
authors.initials: CC
authors.lastname: Ton
authors.forename: V
authors.initials: V
authors.lastname: Huff
authors.forename: K M
authors.initials: KM
authors.lastname: Call
authors.forename: S
authors.initials: S
authors.lastname: Cohn
authors.forename: L C
authors.initials: LC
authors.lastname: Strong
authors.forename: D E
authors.initials: DE
authors.lastname: Housman
authors.forename: G F
authors.initials: GF
authors.lastname: Saunders
mesh_terms: D002675:Child, Preschool; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D008297:Male; D015183:Restriction Mapping; D009396:Wilms Tumor / Q000235:genetics*; D016335:Zinc Fingers / Q000235:genetics*