Nucleotide and deduced amino acid sequences of the gene encoding virion protein 16 of herpes simplex virus type 2.
A virion protein (VP16) of herpes simplex virus (HSV) activates transcription of viral immediate-early genes. We have determined the nucleotide sequence of the virion activator gene from HSV-2, which we term VP16-2. Comparison of the deduced amino acid sequences of the HSV-1 and HSV-2 homologs shows that the VP16-2 gene product retains features determined to be important for transcriptional activation by VP16.
Cress
A
A
Department of Biochemistry, Michigan State University, East Lansing 48824-1319.
Triezenberg
S J
SJ
D000595:Amino Acid Sequence; D001483:Base Sequence; D005814:Genes, Viral / Q000235:genetics*; D017405:Herpes Simplex Virus Protein Vmw65; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D018139:Simplexvirus / Q000235:genetics*; D014158:Transcription, Genetic / Q000502:physiology; D014764:Viral Proteins / Q000235:genetics*
D017405:Herpes Simplex Virus Protein Vmw65; D014764:Viral Proteins