Hemolysis after ABO-incompatible platelet transfusions.
An 18 year old girl, with acute myeloid leukemia, developed progressive hemolysis after receiving multiple transfusions with ABO-incompatible platelets. It was caused by passive transfusion of anti-A and -B isoagglutinin from the donor plasma. Her hemoglobin level returned to normal after giving group compatible or pooled and reduced volume platelet concentrates. Transfusing group-incompatible platelets is not contraindicated, but donor plasma reduction should be considered for those patients who need prolonged platelet support. Testing for isoagglutinin titer in group O donors is an alternate method to reduce the incidence of plasma-induced hemolysis in group-incompatible platelet transfusions.
Chow
M P
MP
Department of Medicine, Veterans General hospital-Taipei.
Yung
C H
CH
Hu
H Y
HY
Tzeng
C H
CH
D000017:ABO Blood-Group System / Q000276:immunology*; D000293:Adolescent; D001787:Blood Group Incompatibility; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D006461:Hemolysis; D006801:Humans; D017713:Platelet Transfusion; D065227:Transfusion Reaction
D000017:ABO Blood-Group System