title: Apolipoprotein B gene expression in rat intestine. The effect of dietary fiber.
abstract: The effect of the dietary fiber on apo B mRNA level was studied in the intestine of rats that were fed either fiber-free or high-fiber (30% sugar-beet fiber) low-fat diets for 3 weeks. The fiber diet studied does not affect jejunal apo B mRNA levels but decreases the level of ileal apo B mRNA. In the rat cecum, in both fiber-free and fiber groups, we failed to detect the apo B mRNA. The test fiber diet feeding markedly increased fecal bile salt and cholesterol excretions. We suggest that dietary fiber can modify apo B expression in the intestine. The increased fecal bile salt excretion might be involved in such a modification.
authors.affiliation: Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique, Theix, Ceyrat, France.
authors.forename: A
authors.initials: A
authors.lastname: Mazur
authors.forename: C
authors.initials: C
authors.lastname: Felgines
authors.forename: F
authors.initials: F
authors.lastname: Nassir
authors.forename: D
authors.initials: D
authors.lastname: Bayle
authors.forename: E
authors.initials: E
authors.lastname: Gueux
authors.forename: C
authors.initials: C
authors.lastname: Rémésy
authors.forename: Y
authors.initials: Y
authors.lastname: Rayssiguier
authors.forename: P
authors.initials: P
authors.lastname: Cardot
mesh_terms: D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics*; D001646:Bile / Q000378:metabolism; D015152:Blotting, Northern; D004043:Dietary Fiber / Q000008:administration & dosage*; D015870:Gene Expression; D007082:Ileum / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001055:Apolipoproteins B; D004043:Dietary Fiber; D012333:RNA, Messenger