[Effect of ceruloplasmin conformation on its activity: significance for clinical analysis].
Conformational properties of ceruloplasmin were studied immediately in blood serum of healthy volunteers, patients with tuberculosis, with pulmonary cancer, with pneumonia and with Wilson-Konovalov disease. The glycoprotein conformation was found to depend on the volunteer physiological state and/or available pathology. The ceruloplasmin conformation and status of its copper-containing sites of the I type affected the enzyme oxidase properties and hence routine colorimetric procedures require some corrections for estimation of ceruloplasmin concentration and activity in blood serum.
Taras'ev
M Iu
MIu
Saburenkova
E P
EP
Dantsig
I I
II
Moshkov
K A
KA
Ryl'kov
V V
VV
D002570:Ceruloplasmin / Q000378:metabolism*; D003124:Colorimetry; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood; D008297:Male; D011014:Pneumonia / Q000097:blood; D011487:Protein Conformation; D012016:Reference Values
D006023:Glycoproteins; D002570:Ceruloplasmin
O vliianii konformatsii tseruloplazmina na ego aktivnost': znachenie dlia klinicheskogo analiza.