[The mechanisms of the stimulation of pancreatic secretion in drawing off its juice from the duodenum].
The effect of atropine on the pancreatic gland's secretion in conditions of partial or complete abduction of the gland's juice from the duodenum, was studied in dogs. Atropine inhibited the secretion if the latter was stimulated with hydrolysin (endogenous peptides) and exerted no such effect in stimulation of the secretion with exogenous peptides. Atropine inhibited the secretion in abduction of the secret from the duodenum. Administration of the secret into the duodenum abolished the atropine effect. Two mechanisms of the secretion inhibition seem to exist: M-cholinergic (low-threshold) and peptidergic (high-threshold) ones.
Korot'ko
G F
GF
Baĭbekova
G D
GD
Nishanova
A A
AA
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D004386:Duodenum / Q000502:physiology*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D011492:Protein Hydrolysates / Q000494:pharmacology; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology; D012633:Secretin / Q000494:pharmacology; D013268:Stimulation, Chemical; D013997:Time Factors
D011492:Protein Hydrolysates; D011976:Receptors, Muscarinic; C007978:hydrolysin; D012633:Secretin; D001285:Atropine
Mekhanizmy stimuliatsii sekretsii podzheludochnoĭ zhelezy pri otvedenii ee soka iz dvenadtsatiperstnoĭ kishki.