title: Long-term potentiation of excitatory and slow inhibitory synaptic potentials in the hippocampal-septal projection of the rat.
abstract: The hippocampal projection to the lateral septum was examined for use-dependent plasticity in a brain slice preparation using intracellular recording. Paired-pulse facilitation and posttetanic potentiation were present. Long-term potentiation (LTP) following high-frequency stimulation was observed after treatment with the GABAA antagonist bicuculline. A slow inhibitory synaptic potential also exhibited long-lasting potentiation after high-frequency stimulation. LTP of both components of the response was sensitive to NMDA antagonists.
authors.affiliation: Department of Psychobiology, University of California, Irvine 92717.
authors.forename: D R
authors.initials: DR
authors.lastname: Stevens
authors.forename: C W
authors.initials: CW
authors.lastname: Cotman
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004558:Electric Stimulation; D004594:Electrophysiology; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D012688:Septum Pellucidum / Q000502:physiology*; D013569:Synapses / Q000187:drug effects / Q000502:physiology*; D009435:Synaptic Transmission
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D001640:Bicuculline