[Adaptation to short stress exposures prevents the enhancement of the endothelium-dependent reactions of the aorta in myocardial infarct].
Acute stress concomitant to the experimental myocardial infarction resulted in endothelial hyperactivation in the rat aorta as manifested in an increased inhibition of norepinephrine-induced contractions of smooth muscle, enhanced endothelium-dependent relaxation and a respective drop of the blood pressure. Preliminary adaptation of rats to short-term non-damaging stress exposure to a considerable extent prevented the stress-induced hyperactivation of endothelium and improved the postinfarction time course of the blood pressure.
Lapshin
A V
AV
Manukhina
E B
EB
Meerson
F Z
FZ
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D009638:Norepinephrine
Adaptatsiia k korotkim stressornym vozdeĭstviiam preduprezhdaet usilenie éndoteliĭzavisimykh reaktsiĭ aorty pri infarkte miokarda.