A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3.
A rat brain cDNA probe was used to localize a gene encoding the alpha 1 subunit of neuronal dihydropyridine-sensitive L-type calcium channels in the mouse and human genomes. Hybridization of the probe to Southern blots made with DNAs from a Chinese hamster x mouse somatic cell hybrid panel indicated that this gene maps to mouse chromosome 14 (Chr 14). Southern blot analysis of an intersubspecies cross demonstrated that the calcium channel alpha 1 subunit gene, termed Cchl1a2, can be positioned 7.5 cM proximal to Np-1. Similarly, segregation among human X rodent somatic cell hybrids indicated that CCHL1A2 maps to human chromosome 3. These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14.
Chin
H M
HM
Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892.
Kozak
C A
CA
Kim
H L
HL
Mock
B
B
McBride
O W
OW
D000818:Animals; D015139:Blotting, Southern; D001921:Brain / Q000378:metabolism*; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics*; D002874:Chromosome Mapping; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009474:Neurons / Q000378:metabolism
D015220:Calcium Channels