title: Conjunctival lymphocytic nodule associated with the Epstein-Barr virus.
abstract: Infection with Epstein-Barr virus has been reported to have numerous systemic and ocular manifestations. In this study, a 38-year-old man with acute infectious mononucleosis was examined for a painless left red eye of three days' duration. The patient had a two-week history of fatigue, low-grade fever, sore throat, and lymphadenopathy. Serologic evaluation was indicative of an acute primary infection with Epstein-Barr virus. A large, salmon-colored, supranasal bulbar conjunctival mass was observed in the left eye. No associated conjunctivitis was present. Biopsy of the conjunctival lesion disclosed a dense leukocytic infiltrate, which consisted primarily of mature lymphocytes and plasma cells. Immunocytochemical evaluation of the tissue with monoclonal antisera disclosed Epstein-Barr latent membrane protein and nuclear protein 2 in a small fraction of the cells constituting the infiltrate. The conjunctival infiltrate resolved completely within one month, paralleling the regression of the patient's lymphadenopathy.
authors.affiliation: Jules Stein Eye Institute, University of California, Los Angeles Medical Center.
authors.forename: B P
authors.initials: BP
authors.lastname: Gardner
authors.forename: T P
authors.initials: TP
authors.lastname: Margolis
authors.forename: B J
authors.initials: BJ
authors.lastname: Mondino
mesh_terms: D000208:Acute Disease; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis / Q000378:metabolism; D036022:Capsid Proteins; D003228:Conjunctiva / Q000473:pathology*; D003229:Conjunctival Diseases / Q000378:metabolism / Q000382:microbiology*; D019309:Epstein-Barr Virus Nuclear Antigens; D005455:Fluorescent Antibody Technique; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007244:Infectious Mononucleosis / Q000382:microbiology; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D014763:Viral Matrix Proteins
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; C041788:Epstein-Barr viral capsid antigen; D007074:Immunoglobulin G; D014763:Viral Matrix Proteins