The regulation of myosin gene transcription in skeletal muscle: effects of altered functional demand.
Perturbations in the activity patterns of skeletal muscle have been used to probe adaptive mechanisms that occur when the function of a muscle is altered. A plethora of information is available concerning the phenotypic changes that occur in the skeletal muscle myosin patterns when the load placed on a muscle is changed. More recently, technological advances in molecular biology have facilitated investigations concerning how these changes at the protein level are mediated via transcription of the genome. The focus of this review will be the recent evidence concerning the regulation of transcription of the myosin isogenes in skeletal muscle. In addition, putative regulatory factors are discussed which may link an alteration in function to altered transcription of the genome.
McDermott
J C
JC
Dept. of Physiology and Biophysics, Dalhousie University Halifax, Nova Scotia.
Bonen
A
A
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D009132:Muscles / Q000378:metabolism / Q000502:physiology*; D009218:Myosins / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics*
D009218:Myosins