Comparative effects of heparin and LMW heparin on hemostasis.
We performed studies to investigate the effect of protamine sulfate neutralization on both the anticoagulant and hemostatic effects of enoxaparin and heparin. Although the anti-Factor Xa effect of enoxaparin was incompletely neutralized by protamine sulfate in an experimental animal model, protamine sulfate reversed bleeding induced by hemorrhagic doses of enoxaparin.
Hirsh
J
J
Department of Pathology, McMaster University, Hamilton, Ont.
Buchanan
M R
MR
D000818:Animals; D000990:Antithrombin III / Q000037:antagonists & inhibitors / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors; D004423:Ear / Q000293:injuries; D004789:Enzyme Activation / Q000187:drug effects; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D006494:Heparin Antagonists / Q000494:pharmacology*; D006495:Heparin, Low-Molecular-Weight / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D009844:Oligosaccharides / Q000378:metabolism; D011479:Protamines / Q000494:pharmacology*; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation / Q000187:drug effects; D011817:Rabbits; D013917:Thrombin / Q000378:metabolism; D014951:Wounds, Stab / Q000150:complications
D001779:Blood Coagulation Factors; D006494:Heparin Antagonists; D006495:Heparin, Low-Molecular-Weight; D009844:Oligosaccharides; D011479:Protamines; C049714:IC 831423; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin