Proton-coupled solute transport in the animal cell plasma membrane.
This review focuses primarily on the progress made in the last couple of years in the understanding of the intestinal peptide transporter, a prototype for H(+)-coupled solute transport systems in the animal cell plasma membrane. The impressive number of transport systems currently known to be energized by the components of the proton-motive force indicates that the role of H+ as the coupling ion for active transport has not been lost during evolution.
Ganapathy
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Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912.
Leibach
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FH
D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000828:Animal Population Groups / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D015820:Cadherins; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004151:Dipeptides / Q000378:metabolism; D004734:Energy Metabolism; D006859:Hydrogen / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D026901:Membrane Transport Proteins; D008871:Microvilli / Q000378:metabolism; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism*; D011522:Protons; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344 / Q000378:metabolism; D013045:Species Specificity
D015820:Cadherins; D002352:Carrier Proteins; C490586:Cdh17 protein, rat; D004151:Dipeptides; D026901:Membrane Transport Proteins; D010455:Peptides; D011522:Protons; C067802:intestinal peptide-proton cotransporter; C004194:glycylsarcosine; D006859:Hydrogen; D000255:Adenosine Triphosphate