title: [The effect of proton therapy on the protein-amino acid metabolism in Itsenko-Cushing disease].
abstract: The composition and blood concentration of free aminoacids and other aminocompounds were investigated using automatic aminoacid analysis by a physiological program in 12 patients with diagnosed corticotropin secreting hypophyseal disease (Itsenko-Cushing disease) before and 1-3 years after proton "hypophysectomy". Imbalance of components of the glucose-alanine cycle, expressed in hypoalaninemia and raised concentration of aminoacids with a bifurcated lateral chain, was detected against a background of marked hypercorticotropinemia and hypercorticolism. Single irradiation of the pituitary gland with a proton beam at absorbed doses of 100-120 Gy in the maximum of a deep field resulted in remission and normalization of aminograms of blood plasma (suggesting pathogenicity of proton-beam therapy) for 6-12 mos. The authors discussed probable mechanisms of the interrelationship of protein-amino-acid and carbohydrate metabolic derangements and their correlation with a type of changes in the hormonal balance.
authors.forename: B A
authors.initials: BA
authors.lastname: Konnov
authors.forename: L A
authors.initials: LA
authors.lastname: Konnova
authors.forename: N A
authors.initials: NA
authors.lastname: Lebedeva
authors.forename: R A
authors.initials: RA
authors.lastname: Shalek
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D003480:Cushing Syndrome / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D011522:Protons; D011882:Radiotherapy, High-Energy
chemical_list: D000596:Amino Acids; D001798:Blood Proteins; D011522:Protons
vernacular_title: Vliianie protonnoĭ terapii na belkovo-aminokislotnyĭ metabolizm pri bolezni Itsenko-Kushinga.