title: The influence of excipients and technological process on cholecalciferol stability and its liberation from tablets.
abstract: The influence of excipients, used in tablet technology, and technological processes on cholecalciferol (1) stability was investigated. It was observed that 1 degrades in the presence of some excipients. The stability of 1 may be increased by antioxidant addition. The best stabilizing effect was achieved by a alpha-tocopherol and ascorbic acid mixture. On the basis of the achieved results, tablets with 1 were prepared. Their physical and chemical properties, the content of 1, its stability and its pharmaceutical availability were determined.
authors.affiliation: Department of Pharmaceutical Technology, Medical Academy, Poznań, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Sawicka
mesh_terms: D000975:Antioxidants; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D002762:Cholecalciferol / Q000032:analysis* / Q000737:chemistry / Q000493:pharmacokinetics; D004355:Drug Stability; D005079:Excipients; D008277:Magnesium Oxide; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical
chemical_list: D000975:Antioxidants; D005079:Excipients; D013607:Tablets; D002762:Cholecalciferol; D008277:Magnesium Oxide