Assignment of the human gene for the alpha 1 subunit of the cardiac DHP-sensitive Ca2+ channel (CCHL1A1) to chromosome 12p12-pter.
A human clone corresponding to the gene encoding the alpha 1 subunit of the cardiac dihydropyridine-sensitive calcium channel (CCHL1A1) has been isolated and partially sequenced. Oligonucleotides based on the human sequence were constructed and used in the polymerase chain reaction to amplify specifically this human gene in human-rodent somatic cell hybrids. Using somatic cell hybrids that contained defined regions of human chromosome 12, the human alpha 1 subunit of the cardiac dihydropyridine-sensitive calcium channel has been assigned to the short arm of chromosome 12 in the interval 12p12-pter.
Powers
P A
PA
Department of Anesthesiology, University of Wisconsin, Madison 53705.
Gregg
R G
RG
Lalley
P A
PA
Liao
M
M
Hogan
K
K
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015220:Calcium Channels / Q000187:drug effects / Q000235:genetics*; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D006224:Cricetinae; D003412:Cricetulus; D004095:Dihydropyridines / Q000494:pharmacology; D005796:Genes; D005804:Genes, Lethal; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics; D008969:Molecular Sequence Data; D009135:Muscular Diseases / Q000235:genetics; D009206:Myocardium / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011817:Rabbits / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D015220:Calcium Channels; D004095:Dihydropyridines; C038806:1,4-dihydropyridine