title: Immunogenicity of tetravalent rhesus rotavirus vaccine administered with buffer and oral polio vaccine.
abstract: Between January and November 1989, we studied 174 infants aged 6 to 16 weeks in a randomized clinical trial to (1) determine the immunogenicity of a single dose of tetravalent rhesus rotavirus vaccine (RRV-TV) when administered with three different buffer regimens: no antacid buffer and small-volume (2.5-mL) and large-volume (30-mL) antacid buffer; and (2) examine the potential interference of RRV-TV on the immune response to oral polio vaccine. Immunogenicity of RRV-TV, measured as a fourfold rise in antibody titers to rotavirus, was similar in the groups receiving small- and large-dose buffer (45% and 49%, respectively) and significantly less in the group that received RRV-TV alone (23%). Administration of RRV-TV with oral polio vaccine did not significantly interfere with the neutralization response of oral polio vaccine poliovirus serotypes 1, 2, or 3, and overall, 29%, 87%, and 24% of the infants had a fourfold rise in titer to each serotype, respectively.
authors.affiliation: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Ing
authors.forename: R I
authors.initials: RI
authors.lastname: Glass
authors.forename: P A
authors.initials: PA
authors.lastname: Woods
authors.forename: M
authors.initials: M
authors.lastname: Simonetti
authors.forename: M A
authors.initials: MA
authors.lastname: Pallansch
authors.forename: W D
authors.initials: WD
authors.lastname: Wilcox
authors.forename: B L
authors.initials: BL
authors.lastname: Davidson
authors.forename: A J
authors.initials: AJ
authors.lastname: Sievert
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D001942:Breast Feeding; D002021:Buffers; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000517:prevention & control; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000517:prevention & control; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D002021:Buffers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011055:Poliovirus Vaccine, Oral; D014765:Viral Vaccines