Treatment of malignant trophoblastic tumors. An analysis of 209 cases.
From 1948 to 1985, a total of 630 cases of choriocarcinoma and invasive mole were treated in our hospital. The methods of treatment varied in different periods of time. In the third period (1972-1985), 5 Fu and/or KSM were the main therapeutic agents used in the treatment of 110 cases of choriocarcinoma and 99 cases of invasive mole. Metastases were observed in more than 90% of cases of choriocarcinoma and nearly 1/4 belonged to stage IV. The mortality of choriocarcinoma decreased from 84.3% to 32.7% after treatment and that of invasive mole from 32.4% to 8.1%. 43 of 80 patients treated with chemotherapy alone conceived after recovery, resulting in a total of 50 pregnancies including 31 term deliveries by 28 women. All the children are normal and healthy, the eldest being 11 years old now.
Wang
S L
SL
Department of Obstetrics and Gynecology, West China University of Medical Sciences, Chengdu.
Zhang
C S
CS
Peng
H Q
HQ
Wu
K H
KH
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002822:Choriocarcinoma / Q000556:secondary / Q000628:therapy*; D003131:Combined Modality Therapy; D003609:Dactinomycin; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000556:secondary / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000628:therapy*
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; C070420:Kengshenmycin; D003609:Dactinomycin; D005472:Fluorouracil