[The dynamic behavioral changes in rats after destruction of the locus coeruleus].
Destruction of locus coeruleus (LC) was conducted in adult rats (male rats of the Wistar line, 250-300 g) electrolytically or by means of 6-hydroxydopamine (6-OHDA). Behaviour of the intact animals sham-operated and of rats with destructed LC was evaluated before and every week after the operation during 5 weeks. Statistically significant alterations in the behaviour were revealed only in the initially low-active rats. These animals were characterized firstly, by low motor and exploratory activity in all tests (open field and automated devices), disturbance of the reactivity to novelty--only in one week after the operation with subsequent compensation of shifts; secondly, by low level of investigatory activity in the open field and absence of habituation to the repetitive tests--from the 21-st day after the operation.
Oknina
N B
NB
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D004564:Electrocoagulation; D005106:Exploratory Behavior / Q000187:drug effects / Q000502:physiology; D008125:Locus Coeruleus / Q000187:drug effects / Q000293:injuries / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D016627:Oxidopamine
Dinamika izmeneniĭ povedeniia krys posle razrusheniia locus coeruleus.