Interleukin-1, interleukin-6: messengers in the neuroendocrine immune system?
Recent findings indicate that interleukin-1 (IL-1) and interleukin-6 (IL-6), cytokines secreted by immunologically activated monocytes and macrophages modulate neuroendocrine function. The site of production (centrally, peripherally), the site of action and the physiological significance of IL-1 and IL-6 as "classical hormones" are questioned.
Hooghe-Peters
E
E
Department of Pharmacology, Faculty of Medicine, Vrije Universiteit Brussel, Belgium.
Velkeniers
B
B
Vanhaelst
L
L
Hooghe
R
R
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D007107:Immune System / Q000502:physiology*; D007375:Interleukin-1 / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D010902:Pituitary Gland / Q000166:cytology / Q000378:metabolism
D007375:Interleukin-1; D015850:Interleukin-6; D000324:Adrenocorticotropic Hormone