Relationship between maternal and neonatal vitamin B6 metabolism: perspectives from enzyme studies.
Enzymes involved in vitamin B6 metabolism, i.e., pyridoxal kinase, pyridoxamine (pyridoxine) 5'-phosphate oxidase, and pyridoxal 5'-phosphate phosphatase, were assayed in hemolysates prepared from cord, maternal, and control blood samples. Mean cord and control pyridoxamine (pyridoxine) 5'-phosphate oxidase activities were significantly higher than maternal activities (p less than 0.001 and p less than 0.05, respectively). A significant correlation (p less than 0.001) was observed between maternal and cord vitamin B6-metabolizing enzymes. Cord pyridoxal 5'-phosphate levels correlated significantly with maternal pyridoxal 5'-phosphate levels (p less than 0.001) and with cord pyridoxal kinase activity (p less than 0.05). Maternal pyridoxal 5'-phosphate levels appear to be the most important factor determining fetal vitamin B6 status.
Delport
R
R
Department of Chemical Pathology, University of Pretoria, South Africa.
Ubbink
J B
JB
Vermaak
W J
WJ
Shaw
A
A
Bissbort
S
S
Becker
P J
PJ
D000293:Adolescent; D000328:Adult; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D006801:Humans; D007231:Infant, Newborn; D010744:Phosphoric Monoester Hydrolases / Q000097:blood*; D011247:Pregnancy; D011731:Pyridoxal Kinase / Q000097:blood*; D011732:Pyridoxal Phosphate / Q000097:blood; D011734:Pyridoxaminephosphate Oxidase / Q000097:blood*; D011736:Pyridoxine / Q000097:blood*
D011732:Pyridoxal Phosphate; D011734:Pyridoxaminephosphate Oxidase; D011731:Pyridoxal Kinase; C027138:pyridoxine phosphate phosphatase; D010744:Phosphoric Monoester Hydrolases; D011736:Pyridoxine