Prenatal delta-9-tetrahydrocannabinol in the rat: effects on auditory startle in adulthood.
Either 15 or 30 mg/kg of delta-9-tetrahydrocannabinol (delta-9-THC) was administered to pregnant rats by gastric intubation from Day 2 through Day 22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were surrogate fostered at birth to untreated dams. When treated and control male and female offspring were tested for differences in auditory startle at 57-60 days of age, no effects were observed among any of the groups. These findings are compared with other neurobehavioral studies of adult offspring prenatally exposed to cannabis.
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New York State Psychiatric Institute, Department of Developmental Psychobiology, NY 10032.
Brake
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Banks
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Nero
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Dick
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Zmitrovich
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D000818:Animals; D013759:Dronabinol / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013216:Reflex, Startle / Q000187:drug effects*
D013759:Dronabinol