Angiotensin II augments the stroke volume response to isoprenaline in man.
Many studies in experimental animal models suggest that there is an interaction between angiotensin II and the sympathetic nervous system. We have now sought evidence for such an interaction using angiotensin II and beta-adrenoceptor stimulation with isoprenaline. Ten normal volunteers were infused with placebo/placebo, placebo/angiotensin II, placebo/isoprenaline and angiotensin II/isoprenaline in a randomized single-blind fashion. Isoprenaline alone caused a non-significant 11-20% rise in stroke volume. Angiotensin II alone caused no significant change in stroke volume. However, the combination of angiotensin II/isoprenaline caused a significant increase in stroke volume of 31-55% (p less than 0.01), and this increase was significantly greater than with isoprenaline alone (P less than 0.02, by repeated-measures analysis of variance). This occurred with no difference in heart rate change. Isoprenaline significantly reduced total peripheral resistance and this reduction was not affected by concomitant infusion of angiotensin II. This study provides evidence that a physiological dose of angiotensin II can synergistically augment the stroke volume effect of beta-agonism in man. There are several possible mechanisms, but a regional redistribution of venous blood which causes increased cardiac filling seems likely.
Seidelin
P H
PH
Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK.
Struthers
A D
AD
D000328:Adult; D000804:Angiotensin II / Q000502:physiology*; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology; D013318:Stroke Volume / Q000187:drug effects*; D014655:Vascular Resistance / Q000187:drug effects
D011943:Receptors, Adrenergic, beta; D000804:Angiotensin II; D007545:Isoproterenol