title: Developmentally controlled genomic rearrangements in ciliated protozoa.
abstract: The ciliated protozoa undergo an extensive genome reorganization during the course of forming a transcriptionally active macronucleus. The process includes numerous chromosome fragmentation and DNA breakage and rejoining events. Recent work indicates that transposable elements play a role in the process.
authors.affiliation: Department of Biochemistry, University of Connecticut Health Center, Farmington 06030.
authors.forename: L A
authors.initials: LA
authors.lastname: Klobutcher
authors.forename: C L
authors.initials: CL
authors.lastname: Jahn
mesh_terms: D000818:Animals; D001483:Base Sequence; D002467:Cell Nucleus / Q000648:ultrastructure; D002875:Chromosomes / Q000648:ultrastructure; D016798:Ciliophora / Q000235:genetics / Q000254:growth & development*; D016384:Consensus Sequence; D004251:DNA Transposable Elements; D016054:DNA, Protozoan / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D015321:Gene Rearrangement; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000235:genetics; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D004251:DNA Transposable Elements; D016054:DNA, Protozoan; D015800:Protozoan Proteins