The synthesis and antiviral activity of some 4'-thio-2'-deoxynucleoside analogues.
A practical 7-step synthesis of benzyl 3,5-di-O-benzyl-2-deoxy-1,4-dithio-D-erythro-pentofuranoside is described and the product has been used in the synthesis of some 4'-thio-2'-deoxynucleosides. These novel nucleoside analogues have potentially useful biological activity and are resistant to phosphorolysis.
Dyson
M R
MR
School of Chemistry, University of Birmingham, UK.
Coe
P L
PL
Walker
R T
RT
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003853:Deoxyribonucleosides / Q000737:chemistry* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014709:Vero Cells; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000998:Antiviral Agents; D003853:Deoxyribonucleosides; D013872:Thionucleosides