Pulmonary aspergillosis complicated by osteomyelitis.
We report on a patient with aplastic anaemia and an invasive aspergillosis of the lung with subsequent osteomyelitis of the ribs. Diagnosis was made by puncture of the soft tissues and isolation of Aspergillus fumigatus. Treatment with amphotericin B induced renal function disturbances. It was successfully replaced by AmBisome. Healing occurred with recovery of the immunity of the patient. The literature on Aspergillus osteomyelitis is reviewed.
De Bock
R
R
Department of Haematology, Universitair Ziekenhuis Antwerpen, Edegem.
Schrijvers
D
D
Peetermans
M
M
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000741:Anemia, Aplastic / Q000150:complications; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D001232:Aspergillus fumigatus / Q000302:isolation & purification; D004337:Drug Carriers; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006801:Humans; D008081:Liposomes; D008297:Male; D010019:Osteomyelitis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology
D004337:Drug Carriers; D008081:Liposomes; C068538:liposomal amphotericin B; D000666:Amphotericin B