title: No association with germline T cell receptor beta-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis.
abstract: Multiple sclerosis (MS) has been reported to be associated with restriction fragment length polymorphism (RFLP)-defined alleles of the T cell receptor (TcR) alpha- and beta-chain genes. One hundred patients with MS, 23 with primarily chronic progressive MS and 77 with relapsing/remitting MS, as well as 100 controls were investigated with RFLP analysis of the V beta 8, V beta 11 and C beta TcR gene segments. No association was found with allelic patterns or, contrary to a previous report (Beall et al. (1989) J. Neuroimmunol. 21, 59-66), TcR beta-chain gene haplotypes. Subgrouping of patients according to clinical form of disease or MS-associated HLA class II alleles also failed to show associations to TcR beta-chain RFLPs. Thus, our results fail to confirm that TcR beta-chain gene haplotypes confer susceptibility to MS.
authors.affiliation: Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Hillert
authors.forename: C
authors.initials: C
authors.lastname: Leng
authors.forename: O
authors.initials: O
authors.lastname: Olerup
mesh_terms: D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D013548:Sweden
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens