[Hepatic arterial infusion of cisplatin microspheres for transplantable hepatocellular carcinoma in rats].
Anti-tumor activity of cisplatin-capsulated microspheres with ethylcellulose (CDDPmc) was studied in Wistar rat bearing transplantable hepatocellular cancer. Seven days after inoculation into the rat's liver, normal saline, conventional cisplatin, placebo ethylcellulose microsphere and CDDPmc at comparable doses were infused into the proper hepatic artery. The results indicated that the rats treated with CDDPmc had a significantly slower tumor growth, more extensive tumor necrosis and longer survival as compared with the three other groups. It is suggested that the tumoricidal effect of arterial chemoembolization with CDDPmc be superior to arterial chemotherapy or embolization alone in the treatment of liver cancer.
Wang
Y
Y
Institute of Hepatobiliary Surgery, Second Military Medical College, Shanghai.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000628:therapy*; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives; D002945:Cisplatin / Q000008:administration & dosage*; D004621:Embolization, Therapeutic; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008863:Microspheres; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D014407:Tumor Cells, Cultured
C013517:ethyl cellulose; D002482:Cellulose; D002945:Cisplatin