title: Evidence of glutamatergic deficiency in schizophrenia.
abstract: Studies of amino acid release were carried out using frozen sections from brains of schizophrenics and controls. Synaptosomes were prepared via differential centrifugation in Ficoll allowing the veratridine-induced release of aspartate, glutamate, glycine, and GABA to be measured. The release of glutamate and gamma-aminobutyric acid (GABA) was reduced in the synaptosomes from schizophrenics. This decrease could be reversed partially by pre-incubation of the synaptosomes with haloperidol. Additionally, the activity of glutamate decarboxylase was decreased and partially restored by haloperidol pre-incubation. These data are consistent with the hypothesis of a glutamatergic/GABAergic deficit in schizophrenia.
authors.affiliation: University of Iowa, Department of Psychiatry, Iowa City 52242.
authors.forename: A D
authors.initials: AD
authors.lastname: Sherman
authors.forename: A T
authors.initials: AT
authors.lastname: Davidson
authors.forename: S
authors.initials: S
authors.lastname: Baruah
authors.forename: T S
authors.initials: TS
authors.lastname: Hegwood
authors.forename: R
authors.initials: R
authors.lastname: Waziri
mesh_terms: D000368:Aged; D001224:Aspartic Acid / Q000378:metabolism; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000737:chemistry / Q000378:metabolism; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism; D005971:Glutamates / Q000172:deficiency*; D018698:Glutamic Acid; D006220:Haloperidol; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000378:metabolism*; D013574:Synaptosomes / Q000737:chemistry / Q000378:metabolism; D014701:Veratridine; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005971:Glutamates; D001224:Aspartic Acid; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D014701:Veratridine; D005968:Glutamate Decarboxylase; D006220:Haloperidol