Opiate and alpha 1-adrenergic receptors in mice responding to morphine with sedation or with running fit.
Two subpopulations of Albino Swiss mice were selected on the basis of their response to a dose of 20 mg/kg ip of morphine: individuals in which the drug constantly produced sedation, and those which responded with running fit. Both subpopulations of mice had cerebral opiate delta and mu receptors (defined as [3H]DADLE and [3H]naloxone binding sites) of similar Bmax and KD values but mice responding with sedation showed lower density of alpha 1-adrenoceptors (defined as [3H]prazosin binding sites) as compared both with mice reacting with running fit or randomly selected animals. Chronic administration of imipramine resulted in a significant increase in the density of [3H]prazosin binding sites in the mice responding with sedation, but not in the animals responding with running fit.
Michaluk
J
J
Department of Biochemistry, Polish Academy of Sciences, Krakow.
Antkiewicz-Michaluk
L
L
Rokosz-Pelc
A
A
Vetulani
J
J
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D016308:Enkephalin, Leucine-2-Alanine / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D011957:Receptors, Opioid / Q000187:drug effects*; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu
D006993:Hypnotics and Sedatives; D011942:Receptors, Adrenergic, alpha; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017450:Receptors, Opioid, mu; D009270:Naloxone; D016308:Enkephalin, Leucine-2-Alanine; D009020:Morphine; D007099:Imipramine; D011224:Prazosin