[The evaluation of the late effect of the multiple administration of immunoglobulin on hepatitis A morbidity in organized collectives].
The analysis of influence in multiple injections of immunoglobulin (IG) on a level of morbidity and the efficiency of IG prophylaxis against hepatitis A in organized collectives made it possible to reveal the following common features: there is a direct dependency between morbidity level and average geometrical anti-IG titers, as well as the number of injections; there is inverse dependency between IG protection activity and the same factors; there is a lack of prophylaxis effect in anti-IG titers 1:32 or more. The authors frame a hypothesis that the reason of epidemic upgrowth of long standing hepatitis A morbidity dynamics in military collectives was conditioned by the wide application of IG in the 70s for children and teenagers.
Katkov
A I
AI
Semenenko
T A
TA
Vasil'eva
V I
VI
D000367:Age Factors; D004341:Drug Evaluation; D006506:Hepatitis A / Q000453:epidemiology / Q000517:prevention & control*; D006508:Hepatitis Antibodies / Q000097:blood; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000276:immunology; D013997:Time Factors; D014586:USSR / Q000453:epidemiology
D006508:Hepatitis Antibodies; D007136:Immunoglobulins
Otsenka otdalennogo vliianiia mnogokratnogo vvedeniia immunoglobulina na zabolevaemost' gepatita A v organizovannykh kollektivakh.