Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial.
Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5 degrees C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42 degrees C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.
Guthkelch
A N
AN
Department of Surgery (Section of Neurosurgery), University of Arizona.
Carter
L P
LP
Cassady
J R
JR
Hynynen
K H
KH
Iacono
R P
RP
Johnson
P C
PC
Obbens
E A
EA
Roemer
R B
RB
Seeger
J F
JF
Shimm
D S
DS
D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000628:therapy; D014464:Ultrasonic Therapy / Q000009:adverse effects / Q000295:instrumentation