Alternatively spliced ltk mRNA in neurons predicts a receptor with a larger putative extracellular domain.
Ltk is a new member of the ros/insulin receptor family of tyrosine kinases that is expressed in murine B-lymphocyte precursors and forebrain neurons. We previously reported that lymphoid ltk cDNAs predict a 69 kDa transmembrane glycoprotein, which uses a CUG translational start codon and has a 110 amino acid putative extracellular domain. We now show that the predominant ltk mRNA in brain is alternatively spliced and predicts a protein with a substantially larger extracellular part. The human ltk gene maps to chromosome 15, bands q13-21, a region containing the breakpoint of a recurring chromosomal abnormality in B-cell non-Hodgkin lymphomas.
Haase
V H
VH
Molecular Genetics Laboratory, Cancer Center of Massachusetts General Hospital, Boston.
Snijders
A J
AJ
Cooke
S M
SM
Teng
M N
MN
Kaul
D
D
Le Beau
M M
MM
Bruns
G A
GA
Bernards
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D001483:Base Sequence; D001921:Brain / Q000502:physiology; D002478:Cells, Cultured; D002871:Chromosome Banding; D002884:Chromosomes, Human, Pair 15; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D004247:DNA / Q000235:genetics; D005091:Exons; D015698:Genomic Library; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009474:Neurons / Q000201:enzymology / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*; D011972:Receptor, Insulin / Q000235:genetics*; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
D003062:Codon; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D004247:DNA; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin