Cocaine produces coronary artery vasoconstriction independent of an intact endothelium.
Studies have demonstrated that cocaine causes coronary vasoconstriction, but this has been unassociated with myocardial ischemia. Therefore, cocaine seems unlikely to precipitate myocardial infarction in the absence of potentiating factors. We hypothesized that injury to coronary endothelium could potentiate cocaine-induced coronary vasoconstriction by decreasing EDRF. The effect of cocaine on LAD diameter was measured in dogs subjected to coronary endothelial denudation and compared with that in a non-denuded control group. Endothelial denudation was accomplished by abrasion with an inflated angioplasty balloon and confirmed in vivo by demonstrating a vasoconstrictive response to infused acetylcholine and by postmortem scanning electron microscopy. Cocaine produced a similar maximal reduction in LAD diameter in both groups. Thus, cocaine induces endothelium-independent coronary artery vasoconstriction. Failure of endothelial injury to potentiate the coronary vasoconstrictive effect by cocaine suggests that factors other than endothelial dysfunction may be important in pathogenesis of cocaine-associated myocardial infarction.
Kuhn
F E
FE
Division of Cardiology, Georgetown University Medical Center, Washington, DC.
Gillis
R A
RA
Virmani
R
R
Visner
M S
MS
Schaer
G L
GL
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D004285:Dogs; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008297:Male; D008855:Microscopy, Electron, Scanning; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology
D003042:Cocaine; D000109:Acetylcholine