[Cyclic ethinyl estradiol and medroxyprogesterone in climacteric women. Their clinicAL efficacy and patterns of uterine bleeding].
The study evaluated the clinical efficacy substitutive hormonotherapy regime in a group of 40 postmenopausal, women with moderate to severe symptomatology and negative progesterone challenge test. Each cycle consisted in the administration of 15 micrograms of ethinyl estradiol during 21 days, plus 10 mg medroxyprogesterone acetate (MPA) the last 10 days. Each patient received four cycles of therapy with 10 days of interval between them. The global clinical response was evaluated as favorable (excellent and good responses) in 97.5% of the patients. All the patients showed an improvement of the vaginal trophism (colpocytology). The great majority of the women experimented cyclical bleeding as consequence of the treatment. The post-therapeutic bleeding (Withdrawal) was the predominant bleeding pattern. This fact suggests that the 10 mg of MPA added daily during 10 days could allow a suitable opposition to the estrogenic proliferative effect inducing an adequate secretory response and the subsequent endometrial desquamation.
Valdivia
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Departamento de Obstetricia y Ginecología, Universidad de Chile.
Campodónico
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D002979:Climacteric / Q000187:drug effects*; D004341:Drug Evaluation; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage* / Q000009:adverse effects; D008593:Menopause / Q000187:drug effects; D008597:Menstrual Cycle / Q000187:drug effects*; D008875:Middle Aged; D011374:Progesterone; D014592:Uterine Hemorrhage / Q000139:chemically induced* / Q000145:classification / Q000453:epidemiology; D014626:Vaginal Smears
D004997:Ethinyl Estradiol; D011374:Progesterone; D017258:Medroxyprogesterone Acetate
Etinil estradiol y medroxiprogesterona cíclicos en mujeres climatéricas. Eficacia clínica y patrones de sangrado uterino.