In vitro and in vivo interactions of drugs used in multidrug therapy in leprosy.
Interactions of different drugs commonly used in multiple drug therapy were evaluated using both in vitro culture (cell-free as well as macrophage) system and mouse footpad. No additive effects were obtained in the in vitro system when dapsone was combined with either rifampicin or clofazimine, while a strong antagonism was observed when clofazimine was combined with rifampicin but not with rifabutin. In the mouse footpad system, a strong synergism was obtained when clofazimine was combined with either rifampicin or rifabutin, but significant antagonism was observed with the combination of clofazimine and dapsone.
Dhople
A M
AM
Department of Biological Sciences, Florida Institute of Technology, Melbourne 32901.
Lamoureux
L C
LC
Gardner
G D
GD
D000818:Animals; D002991:Clofazimine / Q000494:pharmacology*; D003470:Culture Media; D003622:Dapsone / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D007917:Leprostatic Agents / Q000494:pharmacology*; D007918:Leprosy / Q000188:drug therapy / Q000382:microbiology; D051379:Mice; D008826:Microbial Sensitivity Tests; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000254:growth & development; D017828:Rifabutin; D012293:Rifampin / Q000494:pharmacology*; D012294:Rifamycins / Q000494:pharmacology
D003470:Culture Media; D007917:Leprostatic Agents; D012294:Rifamycins; D017828:Rifabutin; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin