title: [Thymidylate synthase inhibition and concentration of 5-fluorouracil after administration of UFT in human uroepithelial carcinomas].
abstract: Inhibition of thymidylate synthase (TS) and the concentration of tegafur, 5-FU and uracil in the tumor and the non-tumor tissues were compared in 18 uroepithelial cancer patients who had been administered UFT (600 mg/day) for seven days before operation. 5-FU and uracil levels in the tumor tissue were increased to 5.1 and 3.6 fold, respectively, compared those in the normal tissue, although there was no difference in tegafur levels between normal and tumor tissue. The mean inhibition rate of TS activity in the tumor tissue was significantly higher (36%) than that in the normal tissue (21%). However, no correlation between 5-FU level and inhibition rate of TS activity was found in either tissue. Not only the higher tumor concentration of 5-FU but also the higher inhibition of TS activity in the tumor tissue suggests that UFT is likely a useful drug for the treatment of uroepithelial carcinomas.
authors.affiliation: Department of Urology, Fukui Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: Kanimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Miwa
authors.forename: H
authors.initials: H
authors.lastname: Akino
authors.forename: Y
authors.initials: Y
authors.lastname: Isomatu
authors.forename: K
authors.initials: K
authors.lastname: Okada
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000201:enzymology / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols; D002295:Carcinoma, Transitional Cell / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005472:Fluorouracil / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D005641:Tegafur / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*; D014018:Tissue Distribution; D014498:Uracil / Q000032:analysis / Q000493:pharmacokinetics / Q000494:pharmacology; D014516:Ureteral Neoplasms / Q000201:enzymology / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000378:metabolism*
chemical_list: D005641:Tegafur; D014498:Uracil; D013940:Thymidylate Synthase; D005472:Fluorouracil