Changes of ATPase activities in erythrocytes of rats with hypothalamic obesity.
Na,K- and Ca,Mg-ATPase activities in the membrane of red blood cells (RBC) were determined in glutamate treated obese rats (GOR). Both activities are related oppositely. In the obese rats the Na,K-ATPase is higher but the efficiency in maintenance of Na/K-ion concentration gradients is diminished. Ca,Mg-ATPase is decreased in GOR. Under the hypermetabolic condition of cold adaption the Na,K-ATPase activity decreases and the Ca,Mg-ATPase activity rises in both animal groups. The Na,K-ATPase activity in RBC-membranes is positively related to fat accumulation and age.
Remke
H
H
University of Leipzig, Institute of Pathological Biochemistry, Germany.
Wilsdorf
A
A
Rehorek
A
A
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D003080:Cold Temperature; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D008297:Male; D008779:Methylthiouracil; D009765:Obesity / Q000097:blood* / Q000139:chemically induced; D010472:Perchlorates; D051381:Rats; D017670:Sodium Compounds; D012970:Sodium Glutamate; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D010472:Perchlorates; D017670:Sodium Compounds; C031068:sodium perchlorate; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D008779:Methylthiouracil; D012970:Sodium Glutamate