Asialoglycoproteins as radiodiagnostic agents for detection of hepatic masses and evaluation of liver function.
The use of targeted radiopharmaceuticals in the diagnosis of hepatic structural and functional defects seems to be a promising new field. Two agents, 99mTc-neogalactoalbumin and 99mTc-asialoorosomucoid, have been used with some success in recent studies. More data, however, needs to be obtained on the kinetics of uptake in various disease states. Comparison studies will also need to be done as new agents are developed.
Makdisi
W F
WF
University of Connecticut School of Medicine, Farmington.
Versland
M R
MR
D000418:Albumins / Q000493:pharmacokinetics; D001212:Asialoglycoproteins; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000502:physiology; D008111:Liver Function Tests / Q000379:methods; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D009961:Orosomucoid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D012709:Serum Albumin / Q000493:pharmacokinetics
D000418:Albumins; D001212:Asialoglycoproteins; D015609:Organotechnetium Compounds; D009961:Orosomucoid; D012709:Serum Albumin; C073390:technetium Tc 99m DTPA asialoorosomucoid; C036586:technetium Tc 99m neogalactoalbumin; D004369:Pentetic Acid