Ultrastructural study on the antileishmanial effect of 1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole in hamsters.
An ultrastructure study was carried out on the effect of a standard drug sodium stibogluconate and a newly identified active CDRI compound 87/305 [1,2-dimethyl-3-methoxy carbonyl-4-(2-nitro-4,5-dimethoxyphenyl) pyrrole] on amastigotes of Leishmania donovani in macrophage cells of spleen of infected hamsters. While Na-stibogluconate exerted its effect by activating the digestion capacity of host macrophages, compound 87/305 was directly lethal to the parasites without, exerting any effect on the host cells.
Bhatnagar
S
S
Division of Parasitology, Central Drug Research Institute, Lucknow.
Maitra
S C
SC
Guru
P Y
PY
Katiyar
J C
JC
D000818:Animals; D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006224:Cricetinae; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008854:Microscopy, Electron; D011758:Pyrroles / Q000494:pharmacology / Q000627:therapeutic use*; D013154:Spleen / Q000469:parasitology / Q000648:ultrastructure
D000981:Antiprotozoal Agents; D011758:Pyrroles; C071527:compound 87-305; D000967:Antimony Sodium Gluconate