Norepinephrine, phentolamine and buflomedil influence on arteriolar vasomotion in the hamster skinfold preparation.
Vasomotion is a potential target for drugs in vascular diseases. In this work, the effects on arteriolar vasomotion of norepinephrine, phentolamine and the vasoactive drug buflomedil were assessed in the hamster skinfold preparation. Results show the strong vasokinetic properties of alpha-sympathetic receptor activation by norepinephrine and an expected depressive effect of the alpha-blocker phentolamine. Buflomedil 10(-4) M enhances vasomotion and arteriolar reactivity and does not interfere with norepinephrine. The mechanism of these properties of buflomedil remains to be investigated.
Carpentier
P H
PH
Laboratorie d'Hémodynamique Périphérique et de Microcirculation, Centre Hospitalier Universitaire de Grenoble, La Tronche, France.
D000818:Animals; D001160:Arterioles / Q000502:physiology*; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014666:Vasomotor System / Q000187:drug effects* / Q000502:physiology
D011759:Pyrrolidines; D011942:Receptors, Adrenergic, alpha; C010651:buflomedil; D009638:Norepinephrine; D010646:Phentolamine