title: Carbon dioxide laser ablation combined with doxorubicin hydrochloride treatment for vaginal fibrosarcoma in a dog.
abstract: The combined use of CO2 laser ablation and doxorubicin hydrochloride (30 mg/m2) administered twice, 4 weeks apart, resulted in complete remission of vaginal fibrosarcoma in a 10-year-old Miniature Poodle. The tumor had redeveloped when only CO2 ablation was used for treatment and doxorubicin hydrochloride alone has had marginal influence on fibrosarcomas; however, use of both treatments in this dog resulted in a 20-month, disease-free period. This treatment combination was minimally traumatic to the dog, easily accomplished, and effective, and it allowed retention of the normal anatomy and function of the urogenital tract.
authors.affiliation: Beckman Laser Institute and Medical Clinic, College of Medicine, University of California-Irvine 92715.
authors.forename: G M
authors.initials: GM
authors.lastname: Peavy
authors.forename: M A
authors.initials: MA
authors.lastname: Rettenmaier
authors.forename: M W
authors.initials: MW
authors.lastname: Berns
mesh_terms: D000818:Animals; D017024:Chemotherapy, Adjuvant; D003127:Colposcopy / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy / Q000601:surgery*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D053685:Laser Therapy / Q000662:veterinary*; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*
chemical_list: D004317:Doxorubicin