Effects of phenolcarboxylic acids on superoxide anion and lipid peroxidation induced by superoxide anion.
The effects of phenolcarboxylic acids, caffeic acid, p-coumaric acid, and ferulic acid on the generation of superoxide anion and the production of lipid peroxide induced by superoxide anion were studied. Only ferulic acid anion among the phenolcarboxylic acids scavenged superoxide. Caffeic acid and ferulic acid inhibited lipid peroxidation induced by superoxide anion. These effects were comparable to those of superoxide dismutase or DL-alpha-tocopherol.
Toda
S
S
Department of Pharmaceutical Science, Kansai Shinkyu Medical College, Osaka, Japan.
Kumura
M
M
Ohnishi
M
M
D002109:Caffeic Acids / Q000494:pharmacology*; D003373:Coumaric Acids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D011422:Propionates; D013481:Superoxides / Q000378:metabolism*
D002109:Caffeic Acids; D003373:Coumaric Acids; D011422:Propionates; D013481:Superoxides; C004999:ferulic acid; C495469:p-coumaric acid; C040048:caffeic acid