[HPV infections in the lower genital tract in the female. Results of beta-interferon treatment].
The Authors have analyzed the results obtained by treating 60 patients affected by HPV lesions of the lower female genital tract (flat vulvar, vaginal and cervical condylomatosis) with beta-interferon. At vulvovaginal level, the action of the drug is independent from the colposcopic aspect of the lesion but is closely correlated to its extension. The drug proved to be more efficacious at cervical level in case of condylomatous cervicitis rather than ANTZ with a reduction in the size of the lesion and disappearance, if present, of the dysplasia. The positive action of the beta-interferon has never occurred before 2-6 months from the end of the farmacologic treatment. The best results have been obtained in case of condylomatous cervicitis with complete remission in 58% of the cases, and in vaginal condylomatosis (CR at 6 months: 45%). On the basis of these results we may conclude that in these HPV lesions priority should be given to medical treatment whereas in vulvar condylomatosis (especially if extended greater than 1/3) where results are not very satisfactory (not more than 20% of CR) physical therapy is advisable.
Pungetti
D
D
II Divisione Ostetrico-Ginecologica, Ospedale Maggiore, Bologna.
Calderara
M A
MA
Vicini
G
G
Selleri
M C
MC
Spadaro
F
F
Zanardi
E
E
D004341:Drug Evaluation; D005260:Female; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use*; D027383:Papillomaviridae / Q000187:drug effects; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000382:microbiology*
D016899:Interferon-beta
Lesioni da HPV del tratto genitale inferiore femminile. Risultati del trattamento con beta-interferone.