[Clinical and experimental study of the effect of kang er xin-I on viral myocarditis].
Kang Er Xin-I (KEX-I) is a proved recipe used to treat viral myocarditis. It consists of Lonicera japonica, Ophiopogon japonicus, Astragalus membranaceus mainly and possesses the effect of clearing away heat and toxic materials and supplementing the vital energy and nourishing. The clinical study was carried out with KEX-I according to a random, paired and cross-over design. Coenzyme Q10 was used as a control and left ventricular function was observed. The result showed: after being treated with KEX-I for two weeks, the 26 patients' chief cardiac functional indexes assessed with STI improved markedly, the value of PEP/LVET and ICT/LVCT all decreased and the difference between the two groups was significant. The experimental study showed that KEX-I can inactivate directly the virus of Coxsackie B3, protect the heart cells in mice, prevent attack by Coxsackie B3, promote the growth of internal interferon and increase the NK cell's function to regulate immunity in experimental mice.
Yan
H J
HJ
Yunnan College of TCM, Kunming.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D027885:Astragalus propinquus; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D029822:Enterovirus B, Human / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009205:Myocarditis / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D016277:Ventricular Function, Left; D014777:Virus Diseases
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal