Recurrent mucocutaneous lymphocytic infiltration possibly associated with Epstein-Barr virus infection.
A 32-year-old man had a history of recurrent but self-healing necrotizing nodules on the face and oral mucosa. Histologically the lesion was composed of necrotizing foci surrounded with dense CD8+ T lymphocytic infiltration in the dermis. Laboratory examination showed marked blood CD8+ T lymphocytosis with a reversed ratio of CD4+/CD8+ of 0.11. Except for a very high titer of antibodies against Epstein-Barr-virus-associated antigens, no signs of infection were observed.
Okada
N
N
Department of Dermatology, Osaka University School of Medicine, Japan.
Tei
H
H
Yamamura
T
T
Sato
K
K
Negoro
S
S
Yoshikawa
K
K
D000328:Adult; D001706:Biopsy; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens; D005148:Facial Dermatoses / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006566:Herpesviridae Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D009059:Mouth Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D009336:Necrosis; D010784:Photomicrography; D012008:Recurrence; D013601:T-Lymphocytes / Q000737:chemistry
D016827:CD8 Antigens; D007070:Immunoglobulin A; D007075:Immunoglobulin M