[The effect of neostigmine on the motor endplate in the intermediate syndrome of organophosphate poisoning].
A patient with severe organophosphate intoxication received Neostigmine 1 mg IV during the intermediate syndrome. This dose resulted clinically and neurophysiologically in a marked deterioration of neuro-muscular transmission. This effect of neostigmine on the neuromuscular block during the intermediate syndrome (deterioration) differs from its effect on a similar pattern (improvement), which is seen in the delayed neuropathy following organophosphate exposure. The administration of therapeutic doses of cholinesterase inhibitors in patients with a reduced safety margin due to inhibition of endplate acetylcholinesterase may be dangerous.
Besser
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Neurologische Klinik und Poliklinik der Universität Mainz.
D000368:Aged; D006801:Humans; D008297:Male; D009045:Motor Endplate / Q000187:drug effects* / Q000502:physiology; D009388:Neostigmine / Q000627:therapeutic use*; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology; D062025:Organophosphate Poisoning; D013406:Suicide, Attempted; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D009388:Neostigmine
Der Effekt von Neostigmin an der motorischen Endplatte beim Intermediärsyndrom der Alkylphosphatvergiftung.