title: A double blind comparative study of lisinopril and enalapril in patients with essential hypertension.
abstract: The efficacy and safety profiles of lisinopril (10-40 mg) and enalapril (5-20 mg) were compared in 169 hypertensive patients during 12 weeks' treatment in a randomised double-blind parallel group study. BP was measured hourly for the first 8 hours following the first dose of lisinopril 10 mg and enalapril 5 mg. The peak reduction in sitting systolic and diastolic BP occurred approximately 6 hours post dose in both groups. At 8 hours post dose lisinopril had reduced sitting systolic and diastolic BP by 2.9 mmHg and 3.5 mmHg (P = 0.02) respectively, more than enalapril with similar results for standing BP. One patient on enalapril developed first dose postural hypotension. After 12 weeks' therapy lisinopril produced a greater decrease (P less than 0.05) in BP than enalapril. Sitting BP decreased by 25/15 mmHg on lisinopril and 17/12 mmHg with enalapril. Standing BP decreased by 24/14 mmHg compared with 16/10 mmHg on enalapril. Eighteen patients did not complete the study, 8 on lisinopril (6 adverse events, 1 uncontrolled BP, 1 protocol violator) and 10 on enalapril (8 adverse events, 1 uncontrolled BP, 1 protocol violator). Overall, the results indicated that while both drugs are well tolerated, the dose range of lisinopril 10-40 mg may produce a greater antihypertensive effect than enalapril 5-20 mg.
authors.affiliation: Queen's, University, Belfast.
authors.forename: G D
authors.initials: GD
authors.lastname: Johnston
authors.forename: D C
authors.initials: DC
authors.lastname: Banks
authors.forename: S
authors.initials: S
authors.lastname: Davies
authors.forename: D
authors.initials: D
authors.lastname: Duffin
authors.forename: J C
authors.initials: JC
authors.lastname: Garnham
authors.forename: D P
authors.initials: DP
authors.lastname: Nicholls
authors.forename: M V
authors.initials: MV
authors.lastname: Raj
authors.forename: S
authors.initials: S
authors.lastname: Mansy
authors.forename: P
authors.initials: P
authors.lastname: Sloan
authors.forename: T M
authors.initials: TM
authors.lastname: Strouthidis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017706:Lisinopril; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D004656:Enalapril; D017706:Lisinopril