[The functional role of neurospecific protein S-100 in memory processes].
Elaboration of alimentary conditioned reflex in rats is accompanied by an increase of the level of protein S-100 in the left and right cerebral hemispheres. Amnestic factor M-cholinolytic atropine disturbs the elaborated habit and simultaneously decreases the quantity of protein S-100 up to the level of unlearned animals. The elaboration of conditioned reflex of passive avoidance does not change the content of protein S-100 in the rats brain. Intracisternal injection of antiserum to protein S-100 has an expressed amnestic action. Intracisternal injection of protein S-100 against the background of amnestic action of cholinolytic does not lead to restoration of memory. The cholinolytic and antiserum to protein S-100 mutually potentiate the amnestic effect.
Gromov
L A
LA
Syrovatskaia
L P
LP
Ovinova
G V
GV
D000647:Amnesia / Q000139:chemically induced / Q000503:physiopathology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002417:Cattle; D002946:Cisterna Magna; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D007106:Immune Sera / Q000302:isolation & purification / Q000494:pharmacology; D007267:Injections; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D009418:S100 Proteins / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology*
D007106:Immune Sera; D009418:S100 Proteins; D001285:Atropine
Funktsional'naia rol' neĭrospetsificheskogo belka S-100 v protsessakh pamiati.