title: Protective effect of inactivated bovine herpesvirus-1 in calves experimentally infected with bovine herpesvirus-1 and Pasteurella haemolytica.
abstract: The protective effect of an inactivated whole-virion bovine herpesvirus-1 (BHV-1) immunising inoculum, without adjuvant, against viral-bacterial respiratory disease was studied in three experimental treatment groups of five calves each. One group was boosted 14 days after the first vaccination and at this time the second group received their initial inoculation. Seven days later, calves were challenged with BHV-1 in aerosol and four days after this challenge all calves were exposed to Pasteurella haemolytica A1 in aerosol. Among the three groups, differences in rectal temperature responses four days after viral challenge (P less than 0.01) did not relate to protection. However the main response variable, viral-bacterial pneumonia, was reduced in boosted calves (P less than 0.05).
authors.affiliation: Agriculture Canada, Animal Diseases Research Institute, Lethbridge, Alberta.
authors.forename: K W
authors.initials: KW
authors.lastname: Jericho
authors.forename: K G
authors.initials: KG
authors.lastname: Loewen
authors.forename: S E
authors.initials: SE
authors.lastname: Smithson
authors.forename: G C
authors.initials: GC
authors.lastname: Kozub
mesh_terms: D000336:Aerosols; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control; D007242:Herpesvirus 1, Bovine / Q000276:immunology* / Q000302:isolation & purification; D007117:Immunization, Secondary / Q000662:veterinary; D007241:Infectious Bovine Rhinotracheitis / Q000150:complications / Q000276:immunology* / Q000517:prevention & control; D007830:Larynx / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D016978:Mannheimia haemolytica / Q000276:immunology* / Q000302:isolation & purification; D009297:Nasal Mucosa / Q000382:microbiology; D014066:Palatine Tonsil / Q000382:microbiology / Q000473:pathology; D012766:Pasteurellosis, Pneumonic / Q000150:complications / Q000517:prevention & control*; D013047:Specific Pathogen-Free Organisms; D014132:Trachea / Q000473:pathology; D014611:Vaccination / Q000662:veterinary; D015164:Vaccines, Inactivated
chemical_list: D000336:Aerosols; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated