Heterogeneous distribution of tetrodotoxin-sensitive calcium-conducting channels in rat hippocampal CA1 neurons.
Voltage-dependent Ca2+ currents (ICas) in neurons can be classified into T-, N- and L-types. In the CA1 pyramidal neurons freshly isolated from rat hippocampus we found an additional tetrodotoxin (TTX)-sensitive Ca2+ current (termed 'TTX-ICa') which passed through the Na+ channel. The TTX-ICa showed a heterogeneous distribution in the dorsal site of Ca1 region.
Akaike
N
N
Department of Neurophysiology, Tohoku University School of Medicine, Sendai, Japan.
Takahashi
K
K
Morimoto
M
M
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D015222:Sodium Channels / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology*
D015220:Calcium Channels; D015222:Sodium Channels; D013779:Tetrodotoxin