Interleukin-6 and retroperitoneal fibromatosis from SRV-2-infected macaques with simian AIDS.
We investigated the role of Interleukin-6 (IL-6) as an autocrine growth factor for the retroperitoneal fibromatosis (RF) cells present in macaques infected with the simian retrovirus type 2 (SRV-2). Elevated levels of IL-6 were found in serum of SRV-2 antibody-positive macaques, ascites from RF-positive animals, and RF cell line culture media. IL-6 mRNA levels increased approximately five-fold in RF cells incubated with exogenous SRV-2. In RF cells, SRV-2 functions to increase IL-6 mRNA and protein production and presumably serves as autocrine growth factor.
Roodman
S T
ST
Department of Pathology, St. Louis University School of Medicine, MO 63104.
Woon
M D
MD
Hoffmann
J W
JW
Theodorakis
P
P
Tsai
C C
CC
Wu
H N
HN
Tsai
C C
CC
D000818:Animals; D002460:Cell Line; D003470:Culture Media; D004797:Enzyme-Linked Immunosorbent Assay; D005350:Fibroma / Q000150:complications*; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis* / Q000097:blood / Q000235:genetics; D008254:Macaca nemestrina; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D012186:Retroperitoneal Neoplasms / Q000150:complications*; D015301:Retroviruses, Simian / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*
D003470:Culture Media; D015850:Interleukin-6; D012333:RNA, Messenger