Apolipoprotein B gene expression in rat intestine. The effect of dietary fiber.
The effect of the dietary fiber on apo B mRNA level was studied in the intestine of rats that were fed either fiber-free or high-fiber (30% sugar-beet fiber) low-fat diets for 3 weeks. The fiber diet studied does not affect jejunal apo B mRNA levels but decreases the level of ileal apo B mRNA. In the rat cecum, in both fiber-free and fiber groups, we failed to detect the apo B mRNA. The test fiber diet feeding markedly increased fecal bile salt and cholesterol excretions. We suggest that dietary fiber can modify apo B expression in the intestine. The increased fecal bile salt excretion might be involved in such a modification.
Mazur
A
A
Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique, Theix, Ceyrat, France.
Felgines
C
C
Nassir
F
F
Bayle
D
D
Gueux
E
E
Rémésy
C
C
Rayssiguier
Y
Y
Cardot
P
P
D000818:Animals; D001055:Apolipoproteins B / Q000235:genetics*; D001646:Bile / Q000378:metabolism; D015152:Blotting, Northern; D004043:Dietary Fiber / Q000008:administration & dosage*; D015870:Gene Expression; D007082:Ileum / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001055:Apolipoproteins B; D004043:Dietary Fiber; D012333:RNA, Messenger