Does peripheral blood T-lymphocyte population distribution in sarcoidosis provide a prognostic clue?
In its pulmonary form, sarcoidosis generally resolves spontaneously, but it may lead to fibrosis of the lung. The clinical, radiological and functional tests, as well as activity markers such as the serum angiotensin converting enzyme, intrathoracic uptake of 67Gallium and the cytological data provided by bronchoalveolar lavage are only the expressions at any given time of a disease which is constantly progressing and only partly express its evolutive potential. The authors studied the distribution of T-lymphocyte subsets in the peripheral blood and from bronchoalveolar lavage. 32 patients were included in the study. They were suffering from acute or chronic sarcoidosis of the mediastinum and lungs and were divided into 2 groups according to clinical, radiological and pulmonary function criteria; Group A (n = 19) included regressive forms (minimum follow up 2 years) and group B (n = 13) the progressive untreated forms. Lymphopenia with a decrease in the percentage of CD3 cells was found in both groups. The percentage of CD4 cells is significantly lower in group B (28 +/- 11%) than in group A (45 +/- 8%) (p < 0.01) or in the control population (46 +/- 8%) (p < 0.01). The percentage of CD8 cells is higher in group B (30 +/- 8%) than in group A (18 +/- 6%). This results in a CD4/CD8 ratio which is significantly reduced in group B (1 +/- 0.5) when compared with group A (2.72 +/- 0.8) (p < 0.01) and the control group (2.17 +/- 0.8) (p < 0.01), the difference between group A and the controls being minimal.(ABSTRACT TRUNCATED AT 250 WORDS)
Desrues
B
B
Service de Pneumologie, Hopital Pontchaillou, Centre Hospitalier Regional et Universitaire, Rennes, France.
Delaval
P
P
Genetet
N
N
Pencole
C
C
Merdrignac
G
G
Dassonville
J
J
L'Huillier
J P
JP
Bourguet
P
P
Kernec
J
J
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D008297:Male; D008477:Mediastinal Diseases / Q000097:blood / Q000276:immunology; D011379:Prognosis; D012507:Sarcoidosis / Q000097:blood / Q000276:immunology*; D017565:Sarcoidosis, Pulmonary / Q000097:blood / Q000276:immunology; D016176:T-Lymphocyte Subsets