[Changes in the immune status of patients with brain tumors in the pre- and postoperative periods].
Changes of the immune status in patients with glioblastomas and meningiomas during the stages of surgical treatment were studied. Functional activity of lymphocytes suffers to a greater measure in patients in the preoperative period and the ratio of the lymphocyte T- and B-subpopulations changes. Preoperative management including hormonal therapy causes further inhibition of the immune status but has no effect on the degree of neurosensitization of the patients, which may be a risk factor of the development of postoperative complications of infectious-inflammatory neuroallergic etiology. Immunogenesis remains inhibited in the early postoperative period, on the 2nd-3rd day after the operation. By the 7th-10th postoperative day significant restoration of the number and functional activity of lymphocytes is encountered in patients with meningiomas, while in patients with glioblastomas inhibition of lymphocyte proliferative activity persists.
Lisianyĭ
N I
NI
Romodanov
S A
SA
Trosh
R M
RM
Rudenko
V A
VA
Radzievskiĭ
A A
AA
D001402:B-Lymphocytes / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology* / Q000601:surgery; D005909:Glioblastoma / Q000276:immunology* / Q000601:surgery; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D008577:Meningeal Neoplasms / Q000276:immunology* / Q000601:surgery; D008579:Meningioma / Q000276:immunology* / Q000601:surgery; D010587:Phagocytosis / Q000276:immunology; D011184:Postoperative Period; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
Izmeneniia immunnogo statusa u bol'nykh s opukholiami golovnogo mozga v do- i posleoperatsionnom periode.