The ATC (ataxia-telangiectasia complementation group C) locus localizes to 11q22-q23.
The multisystem autosomal recessive disease ataxia-telangiectasia (A-T) is determined by several genes, as evidenced by the existence of four complementation groups in this disorder. Using linkage analysis, the ATA (A-T complementation group A) gene was previously localized to chromosome 11, region q22-q23. Analysis of the segregation of RFLP markers from this region in a Jewish-Moroccan family assigned to group C indicates that the ATC (A-T complementation group C) gene localizes to chromosome 11q22-q23 as well.
Ziv
Y
Y
Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel.
Rotman
G
G
Frydman
M
M
Dagan
J
J
Cohen
T
T
Foroud
T
T
Gatti
R A
RA
Shiloh
Y
Y
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D005260:Female; D005816:Genetic Complementation Test; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length