Susceptibility to murine hepatitis virus (type 3)-induced paralysis is influenced by class I genes of the MHC.
Using H-2 recombinant congenic strains of mice, genetic analysis of resistance to murine hepatitis virus type 3 (MHV3)-induced paralysis was performed. It appeared that both H-2K and H-2D, two class I gene regions of the mouse major histocompatibility complex (MHC), can play independent significant roles in the establishment of such resistance.
Oth
D
D
Centre de Recherche en Immunologie, Institut Armand-Frappier, Laval-des-Rapides, Québec, Canada.
Lussier
G
G
Cainelli-Gebara
V C
VC
Dupuy
J M
JM
D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D005260:Female; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D006524:Hepatitis, Viral, Animal / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D006517:Murine hepatitis virus / Q000472:pathogenicity*; D010243:Paralysis / Q000235:genetics* / Q000276:immunology
D006183:H-2 Antigens