title: HLA-Dr expression by tumor cells compared with survival in high grade astrocytomas.
abstract: Frozen samples from 78 high grade astrocytomas were reacted with a monoclonal antibody directed against HLA-Dr invariant chain. Survival data was obtained for all 78 cases. HLA-Dr was expressed by a proportion of tumor cells in 65/78 (83%). Comparison of the survival of positive and negative cases showed that the difference was not statistically significant (p = 0.4). The relevance of the finding is discussed in the context of the immunoreaction to brain tumors.
authors.affiliation: Dept. of Neuropathology and Neurosurgery, Radcliffe Infirmary, Oxford, United Kingdom.
authors.forename: M L
authors.initials: ML
authors.lastname: Rossi
authors.forename: N R
authors.initials: NR
authors.lastname: Jones
authors.forename: G F
authors.initials: GF
authors.lastname: Karr
authors.forename: M M
authors.initials: MM
authors.lastname: Esiri
authors.forename: L
authors.initials: L
authors.lastname: Havas
authors.forename: H B
authors.initials: HB
authors.lastname: Coakham
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D005909:Glioblastoma / Q000276:immunology / Q000401:mortality*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D015996:Survival Rate
chemical_list: D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens