[The noradrenaline and serotonin content in symmetrical parts of the normal rat brain and during learning and peptide administration].
Content was compared of noradrenaline (NA) and serotonine (5-OT) in the right and left halves of the rats brain in norm, at elaboration of defensive conditioned reflexes of two-ways avoidance (CRTWA) and at administration of neuropeptides influencing the learning and memory--dezglycilargininvasopressin (DG-AVP), ACTH4-7 pro-gli-pro and dalargin. The conducted studies showed that in control animals the content of NA in the cortex of the right hemisphere was significantly higher than in the cortex of the left one. For the content of 5-OT in symmetric brain parts no significant differences were revealed. Under the elaboration of CRTWA the asymmetry of NA content was not eliminated. Systemic administration of DG-AVP, ACTG4-7 pro-gli-pro and dalargin practically did not change the content of 5-OT, but reduced the content of NA in the cortex and the rest of the brain, and the content of NA in the right and left cortex was equalized. The obtained data point to the asymmetric character of neuropeptides action and to greater resistance of 5-OT-ergic brain system to functional load and to administration of peptides in comparison with NA-ergic system.
Kruglikov
R I
RI
Orlova
N V
NV
Getsova
V M
VM
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology; D005260:Female; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D009479:Neuropeptides / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000032:analysis / Q000378:metabolism*
D009479:Neuropeptides; D010446:Peptide Fragments; D001127:Arginine Vasopressin; D012701:Serotonin; C015119:argipressin, des-GlyNH2(9)-; D016308:Enkephalin, Leucine-2-Alanine; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; D009638:Norepinephrine
Soderzhanie noradrenalina i serotonina v simmetrichnykh otdelakh mozga krys v norme, pri obuchenii i vvedenii peptidov.