Anti-histone antibodies in subacute sensory neuropathy.
We investigated the levels of anti-histone antibodies in the sera of 7 patients with subacute sensory neuropathy. IgG antibodies to histones H1 and H3 were significantly elevated in 4 of these patients. The anti-H1 antibodies reacted mainly with determinants located in the central globular and the carboxy-terminal domain of the H1 molecule. We also observed reactivity of these sera with histone H1 zero, a variant found in terminally-differentiated cells such as neurons. This study suggests a potential for histones to serve as autoantigens in humorally-mediated paraneoplastic diseases.
Monestier
M
M
Garden State Cancer Center, University of Medicine and Dentistry of New Jersey, Newark.
Fasy
T M
TM
Bohm
L
L
Lieberman
F S
FS
D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D001923:Brain Chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D006657:Histones / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D010523:Peripheral Nervous System Diseases / Q000276:immunology*; D012016:Reference Values
D001323:Autoantibodies; D006657:Histones; D007074:Immunoglobulin G; D007075:Immunoglobulin M