title: A novel class of nucleolar RNAs from Tetrahymena.
abstract: We describe a family of at least four nucleolar RNAs (snoRNAs) from the ciliate, Tetrahymena. The snoRNAs are 120-140 nucleotides long, moderately AU-rich and contain no modified nucleotides. Their 5' ends are blocked by a cap of unknown nature. The snoRNAs can be folded into similar secondary structures consisting of two hairpins separated by a single-stranded AU-rich spacer. The sequences and secondary structures show no extensive sequence or secondary structure resemblance to any other small RNAs in the public databases.
authors.affiliation: Department of Biochemistry B, Panum Institute, University of Copenhagen, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Nielsen
authors.forename: H
authors.initials: H
authors.lastname: Orum
authors.forename: J
authors.initials: J
authors.lastname: Engberg
mesh_terms: D000818:Animals; D001483:Base Sequence; D002466:Cell Nucleolus / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D016053:RNA, Protozoan / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D012342:RNA, Small Nuclear / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D016808:Tetrahymena thermophila / Q000737:chemistry* / Q000235:genetics
chemical_list: D016053:RNA, Protozoan; D012342:RNA, Small Nuclear