title: HIV-associated lymphoma: histopathology and association with Epstein-Barr virus genome related to clinical, immunological and prognostic features.
abstract: All 51 cases of HIV-related malignant lymphoma in Denmark diagnosed from 1983 to 1989 were reviewed. There were 12 Burkitt-type lymphomas, 30 immunoblast-rich lymphomas and 9 other lymphomas. Patients with immunoblast-rich lymphomas had significantly lower CD4 cell counts (median 60 vs. 188 x 10(6)/l, P less than 0.05), and more often a history of previous AIDS-defining illnesses (50% vs. 0%, P less than 0.005), compared with patients with Burkitt-type lymphomas. Epstein-Barr virus (EBV) DNA was demonstrated in 14 of 19 immunoblast-rich tumours, and in 2 of 7 Burkitt-type lymphomas (P = 0.10). Compared with EBV DNA-negative tumours EBV DNA-positive tumours were associated with lower CD4 cell counts (median 39 vs. 188 x 10(6)/l, P = 0.01). It is concluded that two main types of HIV-related malignant lymphoma exist. One is associated with severe immunosuppression, is often of immunoblast-rich morphology, and may be linked to EBV, whereas the other may occur in the absence of immunosuppression, is often of Burkitt-type morphology, and is probably not linked to EBV. In addition to these two main types, other non-Hodgkin lymphomas and Hodgkin's disease do occur.
authors.affiliation: Department of Infectious Diseases, Hvidovre Hospital, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Pedersen
authors.forename: J
authors.initials: J
authors.lastname: Gerstoft
authors.forename: J D
authors.initials: JD
authors.lastname: Lundgren
authors.forename: P
authors.initials: P
authors.lastname: Skinhøj
authors.forename: J
authors.initials: J
authors.lastname: Bøttzauw
authors.forename: C
authors.initials: C
authors.lastname: Geisler
authors.forename: S J
authors.initials: SJ
authors.lastname: Hamilton-Dutoit
authors.forename: S
authors.initials: S
authors.lastname: Thorsen
authors.forename: I
authors.initials: I
authors.lastname: Lisse
authors.forename: E
authors.initials: E
authors.lastname: Ralfkiaer
mesh_terms: D000328:Adult; D000368:Aged; D015704:CD4 Antigens / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D015704:CD4 Antigens; D004279:DNA, Viral