A case of clozapine-induced neuroleptic malignant syndrome.
The treatment of psychotic symptoms in patients with a previous history of neuroleptic malignant syndrome (NMS) remains a dilemma. The authors describe a case in which clozapine caused NMS in a schizophrenic man who had previously experienced NMS during treatment with various antipsychotics. To their knowledge, this is the first report of "classical" NMS caused by clozapine alone.
Miller
D D
DD
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
Sharafuddin
M J
MJ
Kathol
R G
RG
D014150:Antipsychotic Agents / Q000009:adverse effects; D003024:Clozapine / Q000009:adverse effects*; D003620:Dantrolene / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000188:drug therapy / Q000209:etiology*; D012560:Schizophrenia, Catatonic / Q000188:drug therapy* / Q000523:psychology
D014150:Antipsychotic Agents; D003620:Dantrolene; D003024:Clozapine