title: The virulence of British isolates of bovid herpesvirus 1 in relationship to viral genotype.
abstract: Six strains of bovid herpesvirus 1 isolated from British cases of infectious bovine rhinotracheitis (IBR) were inoculated intranasally into calves. The clinical, virological and serological responses were measured and comparisons made between virus strains. Calves infected with viruses of subtype 1 developed more severe clinical signs and excreted higher titres of virus than calves infected with subtype 2b strains. The findings could be related to the history of IBR in Great Britain.
authors.affiliation: Ministry of Agriculture, Fisheries and Food, Central Veterinary Laboratory, Weybridge, Surrey, UK.
authors.forename: S
authors.initials: S
authors.lastname: Edwards
authors.forename: R H
authors.initials: RH
authors.lastname: Newman
authors.forename: H
authors.initials: H
authors.lastname: White
mesh_terms: D000818:Animals; D002417:Cattle; D005838:Genotype; D007242:Herpesvirus 1, Bovine / Q000235:genetics / Q000472:pathogenicity*; D007241:Infectious Bovine Rhinotracheitis / Q000382:microbiology*; D011897:Random Allocation; D014774:Virulence