Potency of several type I-benzodiazepine receptor ligands for inhibition of [3H]flunitrazepam binding in different rat brain tissues.
The potency of several different non-selective and type I-benzodiazepine receptor-selective ligands as inhibitors of [3H]flunitrazepam binding was measured in different rat brain tissues. In contrast to the non-selective ligands, which had a similar potency in all brain tissues investigated, the potency of the type I-receptor-selective ligands was highest in cerebellar membranes and varied in other brain tissues.
Sieghart
W
W
Department of Biochemical Psychiatry, Psychiatrische Universitätsklinik, Vienna, Austria.
Schlerka
W
W
D000375:Aging / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005445:Flunitrazepam / Q000378:metabolism*; D066298:In Vitro Techniques; D008024:Ligands; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism
D008024:Ligands; D011963:Receptors, GABA-A; D005445:Flunitrazepam