title: Eumycetoma caused by Curvularia lunata in a dog.
abstract: Curvularia lunata was cultured from black granules found in granulomatous tumefactions excised from the subcutis of a three year old Medium Schnauzer dog. Draining sinuses were present in some of the tumefactions. Accordingly the diagnosis of eumycotic mycetoma was made. This diagnosis was confirmed by histopathological examination. During the four years following the first surgical intervention, several more similar tumefactions were excised on three different occasions. The dog died of chronic renal failure at the age of 8 years. There was no bone involvement or visceral diffusion of the fungus. The granules were examined by scanning electron microscopy. Immunoglobulins in the dog's serum, assessed by a qualitative test, proved to be equal to immunoglobulins in the serum of a control dog. Precipitating antibodies against C. lunata were not found. The dog was treated for 150 days with itraconazole. In spite of good initial results, recurrence of the fungal lesions were observed after the treatment's interruption. Further treatment with itraconazole for 45 days proved ineffective. No side effects of the drug were observed. This is, to the best of our knowledge, the first case in which C. lunata is identified as the causative agent of an animal eumycetoma.
authors.affiliation: Kimron Veterinary Institute, Beit-Dagan, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Elad
authors.forename: U
authors.initials: U
authors.lastname: Orgad
authors.forename: B
authors.initials: B
authors.lastname: Yakobson
authors.forename: S
authors.initials: S
authors.lastname: Perl
authors.forename: P
authors.initials: P
authors.lastname: Golomb
authors.forename: R
authors.initials: R
authors.lastname: Trainin
authors.forename: I
authors.initials: I
authors.lastname: Tsur
authors.forename: S
authors.initials: S
authors.lastname: Shenkler
authors.forename: A
authors.initials: A
authors.lastname: Bor
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000382:microbiology* / Q000473:pathology; D004285:Dogs; D006099:Granuloma / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D017964:Itraconazole; D007654:Ketoconazole / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008855:Microscopy, Electron, Scanning; D003904:Mitosporic Fungi / Q000187:drug effects / Q000302:isolation & purification* / Q000648:ultrastructure; D008271:Mycetoma / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*
chemical_list: D017964:Itraconazole; D007654:Ketoconazole