title: The synthesis and pharmacological activity of two new derivatives of benzazocine.
abstract: Two new derivatives of benzazocine of anticipated analgesic action were synthesized. Pharmacological investigations were carried out to confirm their analgesic activity, affinity to the opiate receptor and potential antagonistic properties.
authors.affiliation: Department of Chemical Technology of Drugs, Medical Academy, Warszawa, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Gutkowska
authors.forename: S W
authors.initials: SW
authors.lastname: Gumułka
authors.forename: P
authors.initials: P
authors.lastname: Krzaścik
authors.forename: I
authors.initials: I
authors.lastname: Poppe
authors.forename: J
authors.initials: J
authors.lastname: Mészáros
authors.forename: H E
authors.initials: HE
authors.lastname: Makulska
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009292:Narcotic Antagonists / Q000494:pharmacology; D010423:Pentazocine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism; D013055:Spectrophotometry, Infrared
chemical_list: D000700:Analgesics; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D010423:Pentazocine