title: Kinetics of the dual-action mechanism of narcotic substances: conditions for conservative functioning of enzyme-receptor systems.
abstract: We have studied the kinetics of the conservative behavior of systems which are subject to the dual action of an external effector or a negative feedback. Conditions have been found under which the dual-action mechanism produces conservative behavior. Negative feedback alone was shown not to produce the conservative behavior of an enzyme-receptor system.
authors.affiliation: M.V. Lomonosov Moscow State University, USSR.
authors.forename: A D
authors.initials: AD
authors.lastname: Ilyina
authors.forename: S V
authors.initials: SV
authors.lastname: Zaitsev
authors.forename: S D
authors.initials: SD
authors.lastname: Varfolomeyev
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D005246:Feedback; D007700:Kinetics; D008954:Models, Biological; D009294:Narcotics / Q000493:pharmacokinetics / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism
chemical_list: D004798:Enzymes; D009294:Narcotics; D011956:Receptors, Cell Surface