title: Clustering of hepatocellular carcinoma in Alaska Native families.
abstract: Alaska Natives have a high incidence of hepatocellular carcinoma (HCC), with regional, ethnic, village, and familial clustering. During 1969-1988, 15 of the 45 incident cases of HCC in Alaska Natives occurred in 5 families. This report presents epidemiologic, virologic, and immunogenetic data on these 5 families. The results of hepatitis B virus (HBV) serologic testing indicates that HBV infection was an important factor in 4 of the 5 families. Human lymphocyte antigen (HLA) testing was performed in 3 families. The HLA results are reviewed in relationship to the familial clustering of HCC.
authors.affiliation: Arctic Investigations Program, Centers for Disease Control, Anchorage, Alaska 99501.
authors.forename: S R
authors.initials: SR
authors.lastname: Alberts
authors.forename: A P
authors.initials: AP
authors.lastname: Lanier
authors.forename: B J
authors.initials: BJ
authors.lastname: McMahon
authors.forename: A
authors.initials: A
authors.lastname: Harpster
authors.forename: L R
authors.initials: LR
authors.lastname: Bulkow
authors.forename: W L
authors.initials: WL
authors.lastname: Heyward
authors.forename: C
authors.initials: C
authors.lastname: Murray
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000413:Alaska / Q000453:epidemiology; D002277:Carcinoma / Q000208:ethnology*; D006528:Carcinoma, Hepatocellular / Q000208:ethnology*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D005260:Female; D006509:Hepatitis B / Q000208:ethnology; D006801:Humans; D015994:Incidence; D007198:Indians, North American; D004930:Inuit; D008297:Male; D008875:Middle Aged; D010375:Pedigree