Adrenaline-induced tracheal relaxation ex vivo is depressed following aerosol antigen challenge of sensitized guinea-pigs.
We investigated the changes in beta-adrenoceptor responses induced in guinea-pig tracheal and cardiac tissues by the anaphylactic reaction. Antigen aerosol challenge in sensitized guinea-pigs resulted in a marked reduction in adrenaline relaxation in isolated trachea ex vivo. The isoprenaline effect was also slightly decreased by antigen exposure, suggesting a possible impairment of tracheal beta-adrenoceptor function. On the other hand, the chronotropic and inotropic activity of adrenaline in isolated atria was not modified by the anaphylactic shock, suggesting a specific involvement of lung beta-adrenoceptors in the allergic reaction.
Daffonchio
L
L
Institute of Pharmacological Sciences, University of Milan, Italy.
Hernandez
A
A
Omini
C
C
D000336:Aerosols; D000707:Anaphylaxis / Q000503:physiopathology; D000818:Animals; D000941:Antigens / Q000276:immunology*; D004837:Epinephrine / Q000494:pharmacology* / Q000502:physiology; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000502:physiology; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D010047:Ovalbumin / Q000276:immunology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D014132:Trachea / Q000187:drug effects
D000336:Aerosols; D000941:Antigens; D011943:Receptors, Adrenergic, beta; D010047:Ovalbumin; D007545:Isoproterenol; D004837:Epinephrine