Angiotensin-induced hypertension chemotherapy in children with advanced solid tumors.
Angiotensin-induced hypertension chemotherapy (IHC) was investigated in six children with the following advanced malignancies: hepatocellular carcinoma, extraskeletal Ewing's sarcoma, sacrococcygeal malignant teratoma, small round cell tumor of the chest wall, hepatoblastoma and osteogenic sarcoma. Partial response was achieved in three of these patients, two showed no change, and in one IHC was used as adjuvant chemotherapy. The side effects of IHC were minimal and tolerable. Angiotensin-IHC may provide a new approach to pediatric cancer chemotherapy.
Fujii
Y
Y
Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan.
Hongo
T
T
Masui
H
H
Chiba
T
T
Furukawa
N
N
Nakajima
H
H
Nasuda
K
K
Yajima
S
S
Horikoshi
Y
Y
Igarashi
Y
Y
D000293:Adolescent; D000804:Angiotensin II / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003050:Coccyx; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007223:Infant; D007262:Infusions, Intravenous; D008113:Liver Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology; D008175:Lung Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000209:etiology / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D012447:Sacrum; D013899:Thoracic Neoplasms / Q000188:drug therapy
D000804:Angiotensin II