title: Circulating CA-195 in hepatocellular carcinoma and metastatic hepatic carcinoma.
abstract: This study was conducted to determine the role of a relatively new tumor marker, CA-195, in the diagnosis of hepatocellular carcinoma and metastatic hepatic carcinoma, and in distinguishing between these two conditions. CA-195 levels were measured using a commercially available immunoradiometric assay (Tandem-R CA-195) in 30 black inpatients with hepatocellular carcinoma, 15 metastatic carcinoma, 10 with amoebic liver abscess, 10 with cirrhosis and 10 normal individuals at King Edward VIII Hospital, Durban. A cutt-off value of 10 u/ml was used. The sensitivity and specificity of CA-195 in hepatocellular carcinoma and metastatic carcinoma was 60% and 22%, and 87% and 42% respectively. False positive results occurred in 5 (50%) patients with amoebic liver abscess, 10 (100%) with cirrhosis and 2 (20%) normal individuals. These results indicate this tumor marker as of limited value in the diagnosis of hepatocellular carcinoma and metastatic carcinoma, and in distinguishing between these conditions.
authors.affiliation: Department of Experimental and Clinical Pharmacology, University of Natal Medical School, Durban, South Africa.
authors.forename: B
authors.initials: B
authors.lastname: Maharaj
authors.forename: S
authors.initials: S
authors.lastname: Pillay
authors.forename: T
authors.initials: T
authors.lastname: Padayachi
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D015592:Immunoradiometric Assay; D008113:Liver Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D009362:Neoplasm Metastasis / Q000175:diagnosis* / Q000276:immunology; D012680:Sensitivity and Specificity; D013019:South Africa / Q000453:epidemiology
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate