title: [Hospital infections and resistance to new antibiotics in intensive care units: relation to diagnostic and therapeutic procedures].
abstract: The results of hospital infection surveillance over an eight-month period in the Intensive Care Unit (ICU) of the University Hospital of Infectious Diseases "Dr Fran Mihaljević", Zagreb, are presented together with the results of the antibiotic resistance of isolated gram-negative bacteria in relation to the clinical material taken for culture. Of 110 strains of gram-negative bacteria isolated, 103 (93.6%) were resistant to ampicillin, 80 (72%) to gentamicin, 74 (67%) to cefotaxime, 50 (45.5%) to pefloxacin. Imipenem, ciprofloxacin, ceftazidime and amikacin were the most active representatives of their respective groups with 5, 25, 49 and 50% of resistant strains. Strains isolated in urinary tract infections were significantly less resistant to amikacin and ceftazidime (p < 0.05) than strains isolated from other sources. Our findings stress the need for close surveillance of antibiotic resistance in these selected groups of patients, and are particularly relevant for planning empirical anmtibiotic therapy of hospital infection in the ICU.
authors.affiliation: Klinika za infektivne bolesti Dr. Fran Mihaljević, Zagreb.
authors.forename: B
authors.initials: B
authors.lastname: Barsić
authors.forename: I
authors.initials: I
authors.lastname: Beus
authors.forename: E
authors.initials: E
authors.lastname: Marton
authors.forename: J
authors.initials: J
authors.lastname: Himbele
authors.forename: N
authors.initials: N
authors.lastname: Kuzmanović
authors.forename: D
authors.initials: D
authors.lastname: Bejuk
mesh_terms: D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology / Q000635:transmission; D004352:Drug Resistance, Microbial; D006801:Humans; D007362:Intensive Care Units
vernacular_title: Bolnicke infekcije i rezistencija na neke novije antibiotike u jedinici intenzivne skrbi: ovisnost o dijagnostićko-terapijskim zahvatima.