The low affinity component of [3H]clonidine binding is absent in the prefrontal cortex of presumptive suicide victims.
Dysfunction in alpha-adrenergic receptor systems has been implicated to be of etiologic significance in depressive illness. The alpha 2-adrenergic ligand [3H]clonidine labels at least two sets of binding sites in normal human prefrontal cortex. We now report that the lower affinity component of [3H]clonidine binding is apparently absent in the prefrontal cortices of presumptive suicide victims.
Andorn
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AC
Department of Psychiatry, Louisiana State University School of Medicine, Shreveport 71130.
D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D003000:Clonidine / Q000378:metabolism*; D003863:Depression / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D012016:Reference Values; D012044:Regression Analysis; D013405:Suicide
D011942:Receptors, Adrenergic, alpha; D003000:Clonidine