[Quinolones in the treatment of acute amebic dysentery].
75 patients with acute ame bic dysentery treated with pipemidic acid (PPA) alone and 11 patients with norfloxacin (NFX) alone constituted two study groups and 30 patients treated with metronidazole (MNZ) formed a control group. It was found that the cure rates of PPA, NFX and MNZ were similar (P greater than 0.05), being 98.67%, 100% and 93.33%, respectively; the number of days to become afebrile and to stop abdominal pain in these three groups was also similar (P greater than 0.05); the number of days to stop diarrhea in PPA group was similar to that in NFX (P greater than 0.05), but it was significantly shorter in these two groups than that in the controls (P less than 0.01 and 0.05). As to adverse drug reactions, PPA had the least, NFX was similar to PPA (P greater than 0.05), but MNZ had significantly more than PPA (P less than 0.01).
Yang
J G
JG
Department of Infectious Diseases, Taizhou Second Municipal People's Hospital.
Wu
F Y
FY
Shen
X J
XJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004404:Dysentery, Amebic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D009643:Norfloxacin / Q000627:therapeutic use; D010876:Pipemidic Acid / Q000627:therapeutic use; D015363:Quinolones / Q000627:therapeutic use*
D015363:Quinolones; D008795:Metronidazole; D010876:Pipemidic Acid; D009643:Norfloxacin