[A microdialysis study of noradrenaline release in the hypothalamus evoked by 2-deoxyglucose in waking rats].
Intracerebral microdialysis was used to examine extracellular concentrations of noradrenaline (NA) in the lateral hypothalamus of alert rats. Desipramine (0.01 mmol) added to the perfusion medium did not change basal NA release. 2-deoxyglucose-induced (500 mg/kg) neuroglycopenia led to an increase in extracellular NA in hypothalamus which reached maximum 10-30 min after drug administration.
Kuz'min
A I
AI
Bogdanov
M B
MB
Medvedev
O S
OS
D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology; D003956:Dialysis / Q000295:instrumentation / Q000379:methods; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D003847:Deoxyglucose; D003891:Desipramine; D009638:Norepinephrine
Mikrodializnoe issledovanie vybrosa noradrenalina v gipotalamuse, vyzvannogo 2-dezoksigliukozoĭ u bodrstvuiushchikh krys.