TGF-beta-like activity produced during regression of exacerbations in multiple sclerosis.
Samples representative of different stages of disease from a longitudinal study of multiple sclerosis patients were tested in the anchorage-independent growth assay for TGF-beta and an increased activity was detected in the supernatants from 2-day blood cell cultures from patients with active disease compared to patients without active disease and healthy donors. Within the group of patients with active disease, the TGF-beta like activity was significantly increased in the subgroup of patients tested during the period of regression of the symptoms where it appeared in 86.9% of the samples. These results suggest that TGF-beta or a TGF-beta like factor may play a role in regeneration processes in multiple sclerosis.
Beck
J
J
Service de Neurologie, Centre Raymond Garcin, Hospital Saint-Anne, Paris.
Rondot
P
P
Jullien
P
P
Wietzerbin
J
J
Lawrence
D A
DA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D009460:Neurologic Examination; D016212:Transforming Growth Factor beta / Q000097:blood*
D000305:Adrenal Cortex Hormones; D016212:Transforming Growth Factor beta; D000324:Adrenocorticotropic Hormone; D001379:Azathioprine