[The pathogenetic bases for chemotherapy in an experimental Salmonella infection].
The effect of etiotropic (polymyxin and adriblastin) and pathogenetic (levamisole and vitamin E) chemotherapy on lipid peroxidation (LPO), phagocyte functional activity and the process and outcomes of Salmonella infection was studied in rabbits. It was shown that development of salmonellosis was accompanied by activation of LPO which was phase-by-phase. There was synchronism in changing of LPO and neutrophilic phagocytic activity. Adriblastin and levamisole stimulated LPO and increased the neutrophilic phagocytic activity. Vitamin E inhibited LPO and had an unfavourable effect on the process and outcomes of the infection. The problem in differential use of the chemotherapeutic drugs with an account of their modulating effect on LPO is discussed.
Martynenko
L D
LD
Shepelev
A P
AP
D000818:Animals; D004317:Doxorubicin / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005609:Free Radicals; D007978:Levamisole / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D011113:Polymyxins / Q000627:therapeutic use; D011817:Rabbits; D012481:Salmonella Infections, Animal / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012486:Salmonella typhimurium; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use
D005609:Free Radicals; D011113:Polymyxins; D014810:Vitamin E; D007978:Levamisole; D004317:Doxorubicin
Patogeneticheskie osnovy khimioterapii éksperimental'noĭ sal'monelleznoĭ infektsii.