A clinico-pathological study of canine Cushing's disease caused by a pituitary carcinoma.
Knowledge of clinico-pathological correlations in canine Cushing's disease is rather poor. Therefore we describe, clinically and pathologically, a case of pituitary tumour-dependent Cushing's disease in an 8-year old female cocker spaniel. Based on our results, the tumour was defined as a non-dexamethasone-suppressive, corticotrophic adenocarcinoma characterized by some new findings such as intracerebral metastases of anti-ACTH-labelled tumour cells and combined alpha-, beta- and gamma 3-MSH immunoreactivity in the tumour.
Boujon
C E
CE
Institute of Animal Pathology, University of Berne, Switzerland.
Ritz
U
U
Rossi
G L
GL
Bestetti
G E
GE
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary / Q000662:veterinary; D002114:Calcinosis / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D003480:Cushing Syndrome / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D003907:Dexamethasone; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D006854:Hydrocortisone / Q000097:blood; D009074:Melanocyte-Stimulating Hormones / Q000032:analysis; D010281:Parathyroid Hormone / Q000097:blood; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D013972:Thyrotropin; D013974:Thyroxine / Q000097:blood
D014408:Biomarkers, Tumor; D010281:Parathyroid Hormone; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin; D009074:Melanocyte-Stimulating Hormones; D013974:Thyroxine; D006854:Hydrocortisone