title: Molecular biology of actin binding proteins: evidence for a common structural domain in the F-actin binding sites of gelsolin and alpha-actinin.
abstract: We review the impact of molecular biology on actin binding proteins, in particular on sequence relationships and expression of clones to dissect properties in vitro. Significant homologies exist between proteins in each class, but we propose, in addition, that common structural features exist between the F-actin binding sites of severing and cross-linking proteins.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge, UK.
authors.forename: M
authors.initials: M
authors.lastname: Way
authors.forename: B
authors.initials: B
authors.lastname: Pope
authors.forename: A
authors.initials: A
authors.lastname: Weeds
mesh_terms: D000185:Actinin / Q000737:chemistry / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D018260:Gelsolin; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000199:Actins; D002135:Calcium-Binding Proteins; D018260:Gelsolin; D008840:Microfilament Proteins; D000185:Actinin