title: Block of receptor response in the stretch receptor neuron of the crayfish by gadolinium.
abstract: The trivalent lanthanide gadolinium was found to block the mechanotransducer response in the stretch receptor neuron of the crayfish. At normal calcium concentration (13.5 mM) a 50 per cent block of the receptor current was found at 395 +/- 59 (mean +/- SD) microM gadolinium. At a calcium concentration of 1.35 mM a 50 per cent block of the receptor current was obtained at 103 +/- 14 (mean +/- SD) microM gadolinium. The potential activated potassium current was also affected by gadolinium. At 200 microM the amplitude of the peak outward current as a result of a 90 mV positive potential step was decreased by about 40 per cent. The fast inward sodium current was decreased less than 10 per cent by gadolinium. It is concluded that in the crayfish stretch receptor gadolinium blocks the receptor current, reflecting block of stretch-activated channels, but at higher concentrations than have been described for other stretch-activated channels. In addition the outward rectifier potassium current is also blocked reflecting a block of potassium channels.
authors.affiliation: Department of Physiology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Swerup
authors.forename: N
authors.initials: N
authors.lastname: Purali
authors.forename: B
authors.initials: B
authors.lastname: Rydqvist
mesh_terms: D000818:Animals; D003400:Astacoidea; D002118:Calcium / Q000494:pharmacology; D004594:Electrophysiology; D005682:Gadolinium / Q000494:pharmacology*; D008465:Mechanoreceptors / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010812:Physical Stimulation; D015221:Potassium Channels / Q000187:drug effects; D015222:Sodium Channels / Q000187:drug effects
chemical_list: D015221:Potassium Channels; D015222:Sodium Channels; D005682:Gadolinium; D002118:Calcium