title: [Synthesis of new test reagents for the estrogen receptor in human breast cancer tissues].
abstract: According to the character of structure and activity of the test reagents I-IV, two new reagents V and VI for detecting estrogen receptor of human mammary cancer cells were synthesized. This simplifies the route of synthesis and increases activity. Key intermediates VIII and IX were confirmed by IR, MS, UV and elemental analysis. The quantification of the final products V and VI were determined by UV. The result of preliminary clinico-pathological test shows compound V to be effective on estrogen receptor.
authors.affiliation: School of Pharmacy, West China University of Medical Sciences, Chengdu.
authors.forename: F
authors.initials: F
authors.lastname: Mao
authors.forename: L L
authors.initials: LL
authors.lastname: Weng
authors.forename: H
authors.initials: H
authors.lastname: Zheng
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D004966:Estrogens, Conjugated (USP) / Q000138:chemical synthesis*; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006801:Humans; D011933:Reagent Kits, Diagnostic; D011960:Receptors, Estrogen / Q000032:analysis*
chemical_list: D004966:Estrogens, Conjugated (USP); D011933:Reagent Kits, Diagnostic; D011960:Receptors, Estrogen; C073854:ethinyl estradiol 17-hemisuccinate; C002912:estradiol-6-(O-carboxymethyl)oxime; D004997:Ethinyl Estradiol; D004958:Estradiol