Plasma vitamin E, total lipids and myeloperoxidase levels during spinal surgery. A comparison between two anesthetic agents: propofol and isoflurane.
Plasma levels of vitamin E (Vit. E), total lipids (TL), Vit. E to TL ratio and myeloperoxidase (MPO) were studied in 20 patients undergoing lumbar spinal surgery and randomly allocated to two anesthetic groups: propofol (bolus dose + continuous infusion and thiopental/isoflurane. Peripheral blood samples were withdrawn prior to induction, each hour during anesthesia and 1 h after the end of surgery. Mean Vit. E and TL levels as well as mean Vit. E to TL ratios remained in the normal range over the entire period of study whatever the anesthetic regimen. MPO levels rose significantly in the post-operative period only, but without statistical difference between the two groups. Therefore, anesthesia with propofol or thiopental/isoflurane modifies neither total lipid concentrations nor plasma Vit. E, which is a potent endogenous inhibitor of lipid peroxidation bound to lipoproteins. The rise of plasma MPO suggests a moderate post-operative neutrophil activation which is not influenced by anesthetic techniques.
Hans
P
P
Department of Anesthesiology, University Hospital of Liège, Belgium.
Canivet
J L
JL
Pincemail
J
J
Muller
J P
JP
Byttebier
G
G
Lamy
M
M
D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D005260:Female; D006801:Humans; D007530:Isoflurane; D008055:Lipids / Q000097:blood*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D015742:Propofol; D014810:Vitamin E / Q000097:blood*
D008055:Lipids; D014810:Vitamin E; D007530:Isoflurane; D009195:Peroxidase; D015742:Propofol