title: Familial juvenile polyposis coli and colorectal cancer.
abstract: A 40-year-old mother and her 7-year-old son underwent colectomy for polyposis coli. Both colectomy specimens contained predominantly juvenile polyps. The mother's specimen also had numerous tubular adenomas and one 5-cm severely dysplastic villous adenoma without invasive carcinoma. Foci of adenomatous change in juvenile polyps were present in the son's specimen. The histologic features of both cases suggest a sequence of change from juvenile polyps to adenomatous polyps to cancer.
authors.affiliation: Department of Surgery, University College, Dublin, Ireland.
authors.forename: D S
authors.initials: DS
authors.lastname: O'Riordain
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Dwyer
authors.forename: A F
authors.initials: AF
authors.lastname: Cullen
authors.forename: E W
authors.initials: EW
authors.lastname: McDermott
authors.forename: J J
authors.initials: JJ
authors.lastname: Murphy
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000473:pathology*; D000328:Adult; D002648:Child; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D011230:Precancerous Conditions