title: Effects of aphakia on the geniculostriate system of infant rhesus monkeys.
abstract: The effects on the visual system of rearing rhesus monkeys with monocular aphakia, corrected with extended-wear contact lenses, were assessed with anatomical, electrophysiological and behavioral methods. The major finding was that the effects of the various treatments on the aphakic eye varied in degree depending upon the amount of focused pattern input received by the aphakic eye compared to its fellow eye. The behavioral, electrophysiological and anatomical assessments of the treatment effects on the aphakic eyes correlated closely with each other. Because this experimental paradigm is similar to current clinical procedures for treating human infantile monocular cataracts, it provides a nonhuman primate model for studying aphakia.
authors.affiliation: Yerkes Regional Primate Research Center, Emory University, Atlanta, Ga.
authors.forename: J R
authors.initials: JR
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Tigges
authors.forename: R G
authors.initials: RG
authors.lastname: Boothe
authors.forename: J
authors.initials: J
authors.lastname: Tigges
authors.forename: J A
authors.initials: JA
authors.lastname: Gammon
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001036:Aphakia, Postcataract / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology; D004195:Disease Models, Animal; D003576:Electron Transport Complex IV / Q000032:analysis; D005829:Geniculate Bodies / Q000033:anatomy & histology / Q000503:physiopathology*; D008253:Macaca mulatta / Q000502:physiology; D009562:Nissl Bodies / Q000648:ultrastructure; D014792:Visual Acuity; D014793:Visual Cortex / Q000503:physiopathology*
chemical_list: D003576:Electron Transport Complex IV