[The modelling of hepatitis A in macaques].
Characteristics of experimental hepatitis A in Macaca fascicularis and M. mulatta produced with HAV, strain MP, isolated from M. mulatta in an outbreak of spontaneous hepatitis are presented. The HAV-MP strain induced the disease in all the animals used in the experiment. The infection was manifest, with all virological, serological, biochemical and morphological features typical of hepatitis A. In M. mulatta, the process was protracted, with virus persistence in feces for at least 4 months. Modeling of hepatitis A in Macaca monkeys using HAV-MP strain may be used for the study of the pathogenesis and trials of immune preparations.
Korzaia
L I
LI
Shevtsova
Z V
ZV
Krylova
R I
RI
Belova
E G
EG
Dzhelieva
Z N
ZN
Bystrova
T N
TN
Kopnina
E O
EO
Aleĭnik
M D
MD
D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001707:Biopsy, Needle; D004195:Disease Models, Animal; D005243:Feces / Q000737:chemistry / Q000382:microbiology; D006506:Hepatitis A / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D006508:Hepatitis Antibodies / Q000032:analysis; D006507:Hepatovirus / Q000276:immunology / Q000472:pathogenicity; D008099:Liver / Q000473:pathology; D008252:Macaca fascicularis; D008253:Macaca mulatta; D013997:Time Factors; D014771:Virion / Q000276:immunology
D000956:Antigens, Viral; D006508:Hepatitis Antibodies; D000410:Alanine Transaminase
Modelirovanie gepatita A na makakakh.