Glycine prodrug facilitates memory retrieval in humans.
Modulation of glycine concentrations in the brain influences learning and memory functions in experimental animals. We administered milacemide, a glycine prodrug, or placebo to young and older healthy adults, who performed a word-retrieval task. Milacemide administration increased the number of words retrieved and decreased the latency with which these words were retrieved for both young and older adults.
Schwartz
B L
BL
Department of Veterans Affairs Medical Center, Psychiatry Service, Washington, DC 20422.
Hashtroudi
S
S
Herting
R L
RL
Handerson
H
H
Deutsch
S I
SI
D000081:Acetamides / Q000494:pharmacology*; D000328:Adult; D005260:Female; D005998:Glycine / Q000494:pharmacology*; D006801:Humans; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D016202:N-Methylaspartate / Q000494:pharmacology; D010919:Placebos; D011355:Prodrugs / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects*
D000081:Acetamides; D010919:Placebos; D011355:Prodrugs; C039332:milacemide; D016202:N-Methylaspartate; D005998:Glycine