[The characteristics of the action of bradykinin on the functional properties of the mechanoreceptors of the skin and visceral organs in the rat].
In anesthetized rats, nerve filaments innervating receptors of the skin, cardiovascular and respiratory systems were studied. The receptors were sensitive to local mechanical stimulation of the skin. They could be classified as follows: low, middle and high threshold mechanoreceptors. The injection of bradykinin induced an increase of mechanical sensitivity in middle and high threshold receptors and suppressed impulse activity in threshold receptors. Receptors responding to activation of visceral organs were suppressed in the presence of bradykinin. However, injection of bradykinin evoked a tonic discharge in afferent fibres of n. vagi. Mechanisms of bradykinin action are discussed.
Enin
L D
LD
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D002319:Cardiovascular System / Q000294:innervation; D004305:Dose-Response Relationship, Drug; D008465:Mechanoreceptors / Q000187:drug effects* / Q000502:physiology; D010812:Physical Stimulation / Q000295:instrumentation; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000294:innervation; D012867:Skin / Q000294:innervation*; D014781:Viscera / Q000294:innervation*
D001920:Bradykinin
Osobennosti vozdeĭstviia bradikinina na funktsional'nye svoĭstva mekhanoretseptorov kozhi i vistseral'nykh organov krysy.