[Effect of allitridi on cAMP level of arterial wall and plasma of hypercholesterolemic rabbits].
30 New Zealand rabbits weighing 1.5-2.5 kg were all fed a common diet and subdivided into 3 groups. Group 1 (the control), group II received cholesterol (0.5 g/kg.d), while group III was added cholesterol (0.5 g/kg.d) and the allitridi (20 mg/kg.d). Blood cholesterol, cAMP and artery cAMP were determined by the usual technique. The results showed that serum cholesterol level was significantly reduced by allitridi during the 15 weeks period of study and the artery wall cAMP level of group I and group III were significantly higher than group II. But there was no significantly difference between group I and III. The difference of cAMP level in plasma was not significant.
Gao
C Y
CY
Institute of Basic Medicine, Shandong Academy of Medical Science, Jinan.
Xu
Y J
YJ
D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D000242:Cyclic AMP / Q000378:metabolism*; D005260:Female; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents; D008297:Male; D011817:Rabbits; D013440:Sulfides / Q000494:pharmacology*
D000498:Allyl Compounds; D000960:Hypolipidemic Agents; D013440:Sulfides; C042577:diallyl trisulfide; D002784:Cholesterol; D000242:Cyclic AMP