Histamine receptors in the lung.
Histamine, which has long been implicated as a mediator of allergic airway disease, has multiple effects on airways which are mediated by at least three histamine receptors. H1-receptors mediate bronchoconstriction, vasoconstriction and dilatation, microvascular leak and activation of sensory nerves. H2-receptors mediate vasodilatation in some species and mucus secretion. H3-receptors mediate vasodilatation in some species and mucus secretion. H3-receptors modulate cholinergic neurotransmission, the release of neuropeptides from sensory nerves and allergen-induced bronchoconstriction.
Barnes
P J
PJ
Department of Thoracic Medicine, National Heart and Lung Institute, London, U.K.
D000818:Animals; D016084:Bronchoconstriction / Q000502:physiology; D006632:Histamine / Q000502:physiology; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000294:innervation / Q000502:physiology*; D011968:Receptors, Histamine / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000502:physiology; D018100:Receptors, Histamine H3
D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D018100:Receptors, Histamine H3; D006632:Histamine