title: Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme.
abstract: We have employed an immunohistochemical analysis to study the ras p21 oncoprotein in a total of 41 brain tumors and 1 reactive gliosis. The tumors included 33 astrocytomas, 1 oligodendroglioma, 2 ependymomas, 1 neurilemmoma, 1 malignant meningioma, 1 neuroblastoma and 2 medulloblastomas. Our results indicate that elevated ras p21 expression is a common feature in a range of brain tumors. In particular, elevated ras p21 expression has been found in 18 out of 24 high grade astrocytomas (malignant astrocytomas and glioblastomas multiforme) compared to 3 out of 9 low grade (well differentiated astrocytomas) (P less than 0.05). These results suggest that ras p21 expression may be an important molecular marker of the malignant astrocytomas and glioblastomas multiforme.
authors.affiliation: Department of Pathology, Children's Hospital Aghia Sophia, Athens, Greece.
authors.forename: D
authors.initials: D
authors.lastname: Arvanitis
authors.forename: A
authors.initials: A
authors.lastname: Malliri
authors.forename: D
authors.initials: D
authors.lastname: Antoniou
authors.forename: S
authors.initials: S
authors.lastname: Linardopoulos
authors.forename: J K
authors.initials: JK
authors.lastname: Field
authors.forename: D A
authors.initials: DA
authors.lastname: Spandidos
mesh_terms: D001254:Astrocytoma / Q000737:chemistry*; D001932:Brain Neoplasms / Q000737:chemistry*; D015870:Gene Expression; D005909:Glioblastoma / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis*
chemical_list: C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)