title: [The effect of aminostimil on the regulation of sexual function in rats].
abstract: The effect of aminostimil: a synthetic drug of the acylhydrazide group, was studied in white rats. Aminostimil decreased the uterus weight but did not interfere with estrogen positive action in ovariectomized (OVX) rats, although it increased the FSH level, abolished the inhibitory effect of estradiol on the FSH secretion and did not change the secretion of the LH. Aminostimil induced accumulation of GnRH in the preoptic area and median eminence area in intact female and male rats, LH concentration in the blood plasma but decreased. The data obtained suggest that the antiestrogenic effect of aminostimil is due to inhibition of the GnRH secretion from the hypothalamus into the portal blood.
authors.forename: O N
authors.initials: ON
authors.lastname: Savchenko
authors.forename: F I
authors.initials: FI
authors.lastname: Proĭmina
authors.forename: E V
authors.initials: EV
authors.lastname: Sekretareva
authors.forename: O A
authors.initials: OA
authors.lastname: Danilova
authors.forename: M N
authors.initials: MN
authors.lastname: Maslova
authors.forename: V A
authors.initials: VA
authors.lastname: Berestov
authors.forename: M G
authors.initials: MG
authors.lastname: Stepanov
authors.forename: T V
authors.initials: TV
authors.lastname: Tavrovskaia
mesh_terms: D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis / Q000187:drug effects; D006065:Gonadotropins, Pituitary / Q000097:blood; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects; D008297:Male; D009919:Orchiectomy; D010052:Ovariectomy; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects* / Q000502:physiology
chemical_list: D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone
vernacular_title: Vliianie aminostimila na reguliatsiiu polovoĭ funktsii u krys.