title: An unusual Alu repeat sequence within the CAD gene.
abstract: There are several hundred thousand members of the Alu repeat family in the human genome. Those Alu elements sequenced to date appear to fit into subfamilies. A novel Alu has been found in an intron of the human CAD gene: it appears to be due to rearrangement between Alu repeats belonging to two different subfamilies. Further sequence data from this intron suggest that the Alu element may have rearranged prior to its entry into the CAD gene. Such findings indicate that, in addition to single nucleotide substitutions and deletions, DNA rearrangements may be a factor in generating the diversity of Alu repeats found in primate genomes.
authors.affiliation: Department of Microbiology and Immunology, University of Kentucky, Albert B. Chandler Medical Center, Lexington 40536-0084.
authors.forename: J N
authors.initials: JN
authors.lastname: Davidson
authors.forename: N H
authors.initials: NH
authors.lastname: Khattar
authors.forename: K C
authors.initials: KC
authors.lastname: Chen
mesh_terms: D000818:Animals; D001221:Aspartate Carbamoyltransferase / Q000235:genetics*; D001483:Base Sequence; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000235:genetics*; D006224:Cricetinae; D015252:Deoxyribonucleases, Type II Site-Specific; D004080:Dihydroorotase / Q000235:genetics*; D015321:Gene Rearrangement; D006801:Humans; D007438:Introns; D008647:Mesocricetus; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D016415:Sequence Alignment
chemical_list: C033626:CAD trifunctional enzyme; D009097:Multienzyme Complexes; D001221:Aspartate Carbamoyltransferase; C024669:endodeoxyribonuclease AluI; D015252:Deoxyribonucleases, Type II Site-Specific; D004080:Dihydroorotase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)