[Cholecystectomy and colorectal cancer].
Secondary bile acids act as co-carcinogens during genesis of colo-rectal carcinomas. That implies the question wether the patient's situation after cholecystectomy, which is characterized by an increased content of secondary bile acids in the whole pool and a raised intestinal circulation, supports the growth of colo-rectal carcinomas or not. We retrospectively analysed the anamnesis of 189 patients suffering from colorectal carcinomas and found a significantly increased number of cholecystectomized people in comparison with a Berlin normal population according to an autopsy study. The relative risk for the whole colon and rectum amounted to 1.53 and for proximal colon to 2,1. The connection between cholecystectomy and colorectal carcinomas seems to be not close enough to define risk groups. However, it entitles to demand the very consequent observance of indication of cholecystectomy and to take alternative therapies for maintenance of gallbladder always into consideration.
Nawroth
R
R
Klinik für Chirurgie, Humboldt-Universität, Berlin.
Batsch
M
M
D000230:Adenocarcinoma / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000473:pathology; D001647:Bile Acids and Salts / Q000502:physiology; D002276:Carcinoid Tumor / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002763:Cholecystectomy; D003043:Cocarcinogenesis; D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000473:pathology; D008297:Male; D011183:Postoperative Complications / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors
D001647:Bile Acids and Salts
Cholezystektomie und kolorektales Karzinom.