title: Hepatocellular carcinoma in a long-term survivor of intrahepatic biliary duct hypoplasia.
abstract: We describe the development of hepatocellular carcinoma (HCC) in a 46-yr-old woman with intrahepatic biliary duct hypoplasia. Her underlying liver disease was quiescent for many years until a dramatic rise in serum bilirubin was seen. Orthotopic liver transplantation was performed, and a large tumor was found during surgery. A bile-producing HCC was identified, infiltrating about 50% of an otherwise noncirrhotic liver which had a paucity of intrahepatic ducts. The findings of HCC in this long-term survivor of intrahepatic biliary duct hypoplasia indicates HCC may occur in patients with long-standing disease.
authors.affiliation: Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, City University of New York.
authors.forename: N
authors.initials: N
authors.lastname: Bach
authors.forename: H
authors.initials: H
authors.lastname: Kahn
authors.forename: S N
authors.initials: SN
authors.lastname: Thung
authors.forename: F
authors.initials: F
authors.lastname: Schaffner
authors.forename: F M
authors.initials: FM
authors.lastname: Klion
authors.forename: C M
authors.initials: CM
authors.lastname: Miller
mesh_terms: D001653:Bile Ducts, Intrahepatic / Q000002:abnormalities*; D001663:Bilirubin / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000601:surgery; D000013:Congenital Abnormalities / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000601:surgery; D016031:Liver Transplantation; D008875:Middle Aged
chemical_list: D001663:Bilirubin