[The significance of pesticin 1 for the virulence and immunogenicity of Yersinia pestis].
The work deals with the study of the virulent and immunogenic properties of Y. pestis strains which lost their capacity for producing pesticine 1 as the result of the insertion of a Tn-like element into the 6-MD plasmid responsible for this property. The "switching-off" of gene pst induced a decrease in the virulence of Y. pestis injected subcutaneously into white mice and guinea pigs and had no influence on its level of immunogenicity for white mice. A suggestion was made that pesticine 1 played no essential role in the expression of the virulence and immunogenicity of Y. pestis penetrating into the body by subcutaneous route.
Grebtsova
N N
NN
Cherniavskaia
A S
AS
Lebedeva
S A
SA
D000818:Animals; D001430:Bacteriocins / Q000096:biosynthesis / Q000276:immunology*; D004251:DNA Transposable Elements / Q000235:genetics / Q000276:immunology; D005798:Genes, Bacterial / Q000235:genetics / Q000276:immunology; D005819:Genetic Markers / Q000235:genetics / Q000276:immunology*; D014644:Genetic Variation / Q000235:genetics / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization; D051379:Mice; D010957:Plasmids / Q000235:genetics / Q000276:immunology; D014774:Virulence / Q000235:genetics / Q000276:immunology; D015010:Yersinia pestis / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*
D001430:Bacteriocins; D004251:DNA Transposable Elements; D005819:Genetic Markers; C011330:Pesticin
Izuchenie znachimosti pestitsina 1 dlia virulentnosti i immunogennosti Yersinia pestis.