[Increase of alpha 1-adrenoreactivity of the rat heart in adaptation to periodic hypoxia].
There is a possibility that the cardioprotective effect of adaptation to intermittent hypoxia is due to changes in receptors apparatus of the heart. In this connection the effect of preliminary adaptation to intermittent hypoxia (4 hours per day at the altitude of 4000 m during 40 days) on the state of beta-receptors-adenylate-cyclase system and same other receptors of the heart were studied. It was shown that at the end of the course of adaptation the number of beta-adrenoceptors in the heart was increased with simultaneous decrease in basal adenylate-cyclase activity, accompanied by the diminution of its response to beta-agonist. The number of beta-adrenoceptors was increased by 48% and their affinity to ligand was increased by almost 2 times. The revealed decrease in the reactivity of beta-receptor-adenylate-cyclase system and increase of alpha 1-adrenoreactivity can play a certain role in the mechanism of cardioprotective effect of adaptation to hypoxia.
Meerson
F Z
FZ
Kopylov
Iu N
IuN
Baldenkov
G N
GN
D000222:Adaptation, Physiological; D000262:Adenylyl Cyclases / Q000032:analysis; D000818:Animals; D006321:Heart / Q000294:innervation / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D010507:Periodicity; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D013997:Time Factors
D011942:Receptors, Adrenergic, alpha; D000262:Adenylyl Cyclases
Povyshenie alfa 1-adrenoreaktivnosti serdtsa krys pri adaptatsii k periodicheskoĭ gipoksii.