title: Isoprenaline cannot act on pancreatic beta cells without hyperglycemia or alpha-block.
abstract: During long-term increase in isoprenaline (pronounced beta-effect) and isoprenaline plus regitine (pure beta-effect) pancreatic insulin-secretion still depended mostly on blood glucose levels. This means that increased beta-effect during normo- or hypoglycemia could not cause a higher insulin-secretion. Only during additional alpha-receptor blockade insulin-secretion was slightly but insufficiently increased. Catecholamines seem to be more regulator than originator of the insulin secretory process.
authors.affiliation: University of Graz, Institute of Functional Pathology, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Porta
authors.forename: C
authors.initials: C
authors.lastname: Himly
authors.forename: I
authors.initials: I
authors.lastname: Rinner
authors.forename: U
authors.initials: U
authors.lastname: Schwarz
authors.forename: M
authors.initials: M
authors.lastname: Werner
authors.forename: B
authors.initials: B
authors.lastname: Poncza
authors.forename: W
authors.initials: W
authors.lastname: Korsatko
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D007545:Isoproterenol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010179:Pancreas / Q000378:metabolism; D010646:Phentolamine / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011942:Receptors, Adrenergic, alpha; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine