Evaluation of the efficacy of a low-passage bovine rotavirus (strain WC3) vaccine in children in Central Africa.
The safety and efficacy of a WC3 rotavirus vaccine was evaluated in a double-blind placebo-controlled trial involving 472 children in Bangui (Central African Republic). Each child received two doses of either placebo (235 children) or vaccine (237 children) at a 1-month interval, the first dose being given at 3 months of age. During the follow-up survey 9 months after the first dose, 117 rotavirus diarrhoeas were observed, 59 in the placebo group, 58 in the vaccinated group. The only positive effect of the vaccine was a significantly higher proportion of mild rotavirus diarrhoeal episodes in the vaccinated group than in the placebo group. Of the children in the vaccinated group, 60% had a positive immune response to WC3 rotavirus when tested by plaque reduction seroneutralization.
Georges-Courbot
M C
MC
Institut Pasteur, Bangui.
Monges
J
J
Siopathis
M R
MR
Roungou
J B
JB
Gresenguet
G
G
Bellec
L
L
Bouquety
J C
JC
Lanckriet
C
C
Cadoz
M
M
Hessel
L
L
D000350:Africa, Central / Q000453:epidemiology; D000818:Animals; D002417:Cattle; D015331:Cohort Studies; D003968:Diarrhea, Infantile / Q000453:epidemiology / Q000517:prevention & control; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines; D014765:Viral Vaccines / Q000009:adverse effects
D022243:Rotavirus Vaccines; D014765:Viral Vaccines; C058442:WC3 rotavirus vaccine