title: Presence of human papillomavirus type 18 DNA in a pharyngeal and a laryngeal carcinoma.
abstract: We examined the presence of human papillomavirus (HPV) genome in pharyngeal and laryngeal squamous cell carcinomas by employing the polymerase chain reaction. We detected HPV 16 DNA in one of 11 pharyngeal carcinomas and in 3 of 28 laryngeal carcinomas, and HPV 18 DNA in a pharyngeal and a laryngeal carcinoma. In one of the laryngeal carcinomas, DNA of both HPV types 16 and 18 were detected. To our knowledge, this is the first report of detection of HPV type 18 in head and neck carcinomas.
authors.affiliation: Department of Molecular Virology, Okayama University Medical School.
authors.forename: H
authors.initials: H
authors.lastname: Ogura
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.forename: Y
authors.initials: Y
authors.lastname: Masuda
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Yabe
mesh_terms: D000328:Adult; D000368:Aged; D016375:Antisense Elements (Genetics); D001483:Base Sequence; D002294:Carcinoma, Squamous Cell / Q000382:microbiology*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides; D015345:Oligonucleotide Probes; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D010610:Pharyngeal Neoplasms / Q000382:microbiology*; D016133:Polymerase Chain Reaction / Q000379:methods
chemical_list: D016375:Antisense Elements (Genetics); D004279:DNA, Viral; D009838:Oligodeoxyribonucleotides; D015345:Oligonucleotide Probes