title: [Second solid tumors in childhood. Review based on three cases].
abstract: As children with cancer survive longer, the incidence of second malignant neoplasms has increased considerably. We describe here three cases of second solid tumors after 12, 8 and 2 years of initial diagnosis of cancer: one osteosarcoma of left maxilla in a previously treated child with bilateral retinoblastoma, a temporal astrocytoma associated with acute lymphoblastic leukemia and a glioblastoma multiforme in a girl with neurofibromatosis de Von Recklinghausen, after Non Hodgkin lymphoma, respectively. We review the literature about the influence of genetic, immunologic and therapeutic factors involved in the appearance of these second tumors.
authors.affiliation: Unidad de Oncología Infantil, Departamento de Pediatría, Hospital de Cruces de Baracaldo, Vizaya.
authors.forename: I
authors.initials: I
authors.lastname: Astigarraga Aguirre
authors.forename: A
authors.initials: A
authors.lastname: Navajas Gutiérrez
authors.forename: A
authors.initials: A
authors.lastname: Rivera Aranda
authors.forename: E
authors.initials: E
authors.lastname: Moya Calderón
authors.forename: J L
authors.initials: JL
authors.lastname: Bezanilla Regato
mesh_terms: D001254:Astrocytoma / Q000235:genetics / Q000276:immunology / Q000628:therapy; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000235:genetics / Q000276:immunology / Q000628:therapy; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology / Q000628:therapy; D006801:Humans; D007223:Infant; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000276:immunology / Q000628:therapy; D008297:Male; D008441:Maxillary Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000235:genetics* / Q000276:immunology / Q000628:therapy; D009456:Neurofibromatosis 1 / Q000235:genetics / Q000276:immunology / Q000628:therapy; D012516:Osteosarcoma / Q000235:genetics / Q000276:immunology / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000276:immunology / Q000628:therapy; D012175:Retinoblastoma / Q000235:genetics / Q000276:immunology / Q000628:therapy
vernacular_title: Segundos tumores sólidos en la infancia. Revisión a propósito de tres casos.