Human herpesvirus-6 (HHV-6) (short review).
Human Herpesvirus-6 is the etiological agent of Roseola infantum and approximately 12% of heterophile antibody negative infectious mononucleosis. HHV-6 is T-lymphotropic, and readily infects and lyses CD4+ cells. The prevalence rate of HHV-6 in the general population is about 80% (as measured by IFA) with an IgG antibody titer of 1:80. A lower prevalence, however, is observed in some countries. HHV-6 is reactivated in various malignant and non-malignant diseases as well as in Chronic Fatigue Syndrome and transplant patients. Furthermore, elevated antibody titers were also observed in lymphoproliferative disorders, auto-immune diseases and HIV-1 positive AIDS patients. There appears to be some strain variability in HHV-6 isolates. The GS isolates of HHV-6 (prototype) was resistant to Acyclovir, Gancyclovir, but its replication was inhibited by Phosphonoacetic acid and Phosphoformic acid. HHV-7 isolated from healthy individuals showed, by restriction analysis, that 6 out of 11 probes derived from two strains of HHV-6, cross-hybridized with DNA fragments, derived from HHV-7.
Ablashi
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DV
National Cancer Institute, NIH, Bethesda, MD 20892.
Salahuddin
S Z
SZ
Josephs
S F
SF
Balachandran
N
N
Krueger
G R
GR
Gallo
R C
RC
D005814:Genes, Viral; D006566:Herpesviridae Infections / Q000382:microbiology; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans