title: No confirmation of visual evoked potential diagnostic test for migraine.
abstract: We have attempted to replicate the results of studies on a diagnostic test reported to have 90% sensitivity and 89-96% specificity for migraine. The technique is based on peak-to-peak measurements of fast background electroencephalographic activity during a visual evoked potential (VEP) study. VEP latencies and amplitudes did not differ significantly, and showed substantial overlap, between a group of eight migraine patients and ten age-matched healthy controls. We could not recognise previously described fast activity or measure it objectively by peak-to-peak measurements. We cannot confirm that measurement of fast wave activity in the VEP background is useful in diagnosis of migraine.
authors.affiliation: Department of Neurology/Clinical Neurophysiology, Leiden University Hospital, Netherlands.
authors.forename: J G
authors.initials: JG
authors.lastname: van Dijk
authors.forename: M
authors.initials: M
authors.lastname: Dorresteijn
authors.forename: J
authors.initials: J
authors.lastname: Haan
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
mesh_terms: D000328:Adult; D004569:Electroencephalography; D005069:Evaluation Studies as Topic; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis* / Q000503:physiopathology; D015203:Reproducibility of Results; D013997:Time Factors