title: A spectrum of bilateral squamous conjunctival tumors associated with human papillomavirus type 16.
abstract: Three patients with bilateral tumors presenting as multiple keratinizing and verrucous lesions of the bulbar and tarsal conjunctiva were determined by DNA amplification and hybridization studies to harbor human papillomavirus type 16 (HPV-16). Results of biopsy in two patients showed infiltrating squamous cell carcinoma in one eye and dysplasia or carcinoma in situ in the fellow eye. In the third patient, focal, inflamed, hypertrophic, papillary lesions with pseudoglandular invaginations of the surface epithelium were found in the tarsal conjunctivae of both eyes. These are the first documented cases of bilateral conjunctival tumors associated with human papillomavirus.
authors.affiliation: Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston.
authors.forename: M G
authors.initials: MG
authors.lastname: Odrich
authors.forename: F A
authors.initials: FA
authors.lastname: Jakobiec
authors.forename: W D
authors.initials: WD
authors.lastname: Lancaster
authors.forename: K R
authors.initials: KR
authors.lastname: Kenyon
authors.forename: L D
authors.initials: LD
authors.lastname: Kelly
authors.forename: E W
authors.initials: EW
authors.lastname: Kornmehl
authors.forename: R F
authors.initials: RF
authors.lastname: Steinert
authors.forename: A S
authors.initials: AS
authors.lastname: Grove
authors.forename: J W
authors.initials: JW
authors.lastname: Shore
authors.forename: L
authors.initials: L
authors.lastname: Gregoire
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000150:complications* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D014412:Tumor Virus Infections / Q000150:complications* / Q000235:genetics / Q000473:pathology
chemical_list: D004279:DNA, Viral