title: Phase II trial of daily oral etoposide in patients with advanced non-small cell lung cancer.
abstract: Forty-six previously untreated patients with advanced non-small cell lung cancer (NSCLC) were entered into a Hoosier Oncology Group phase II trial of daily oral etoposide 50 mg/m2/d. The dose limiting toxicity was granulocytopenia. The non-hematologic toxicity was mild, with only 19% of patients developing Grade 3 or 4 leukopenia. Two partial responses of 10 and 16 weeks duration were seen in 43 evaluable patients, for an overall response rate of 4%. We conclude that daily oral etoposide has minimal activity in advanced NSCLC, and does not improve response rates over conventional 1-5 day intravenous etoposide administration.
authors.affiliation: Indiana University, Department of Medicine, Indianapolis.
authors.forename: S
authors.initials: S
authors.lastname: Saxman
authors.forename: P J
authors.initials: PJ
authors.lastname: Loehrer
authors.forename: K
authors.initials: K
authors.lastname: Logie
authors.forename: D
authors.initials: D
authors.lastname: Stephens
authors.forename: F
authors.initials: F
authors.lastname: Workman
authors.forename: D
authors.initials: D
authors.lastname: Scullin
authors.forename: L H
authors.initials: LH
authors.lastname: Einhorn
authors.forename: R
authors.initials: R
authors.lastname: Ansari
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005047:Etoposide / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D005047:Etoposide