Calcium modulation of the N-methyl-D-aspartate (NMDA) response and electrographic seizures in immature hippocampus.
Recordings from the CA3 region of hippocampal slices indicate a developmental change in the divalent cation sensitivity of the response elicited by N-methyl-D-aspartate (NMDA) application. In parallel experiments a developmental difference is demonstrated in the capacity of extracellular calcium to modulate electrographic seizure generation. Calcium modulation of the NMDA-elicited response may contribute to the pronounced capacity of immature hippocampus to generate electrographic seizures. Under these conditions activity dependent changes in extracellular calcium could have a greater influence on ion flow produced by activation of the NMDA receptor. The possibility that changes in the receptor isoform may occur during development would have widespread implications for normal cognitive functions and dysfunctions during brain maturation.
Brady
R J
RJ
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.
Smith
K L
KL
Swann
J W
JW
D000367:Age Factors; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects; D004347:Drug Interactions; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D018756:GABA Antagonists; D006624:Hippocampus / Q000187:drug effects* / Q000254:growth & development / Q000503:physiopathology; D015640:Ion Channel Gating / Q000187:drug effects; D016202:N-Methylaspartate / Q000494:pharmacology / Q000633:toxicity*; D010406:Penicillins / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D016318:Quisqualic Acid / Q000494:pharmacology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology
D002118:Calcium; D015220:Calcium Channels; D018756:GABA Antagonists; D016202:N-Methylaspartate; D010406:Penicillins; D010852:Picrotoxin; D016318:Quisqualic Acid; D016194:Receptors, N-Methyl-D-Aspartate; D013779:Tetrodotoxin