[The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma].
In order to clarify whether repirinast, an inhibitor of chemical mediator release, could influence the pharmacokinetics of theophylline, a loading test using intravenous injection of aminophylline was performed in 10 subjects with bronchial asthma before and after treatment with 300 mg/day of repirinast. There was no significant difference in theophylline half-life before treatment (7.25 +/- 2.43 hr) and after treatment (7.82 +/- 3.35 hr). There was no significant difference in theophylline clearance before treatment (0.047 +/- 0.018 L/kg/hr) and after treatment (0.047 +/- 0.020 L/kg/hr). These results demonstrated that repirinast does not modify theophylline pharmacokinetics significantly.
Nagata
M
M
Second Department of Internal Medicine, Saitama Medical School.
Tabe
K
K
Houya
I
I
Kiuchi
H
H
Sakamoto
Y
Y
Yamamoto
K
K
Dohi
Y
Y
D000328:Adult; D000368:Aged; D001249:Asthma / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D015363:Quinolones / Q000494:pharmacology*; D013806:Theophylline / Q000493:pharmacokinetics*
D015363:Quinolones; C048522:repirinast; D013806:Theophylline