title: Lesion of the nucleus basalis magnocellularis does not affect cerebral cortical blood flow in rats.
abstract: The effects of a unilateral ibotenic acid lesion of the nucleus basalis magnocellularis (NBM) on blood flow of the cerebral cortex and striatum were studied at 2, 4, 8 and 16 weeks after the lesion in conscious rats. In the cerebral cortex, no side-to-side difference in blood flow was observed, though cholinergic enzyme activity was markedly reduced on the side of the lesion. The results suggest that NBM lesion produces disturbance of cholinergic neurons in the cerebral cortex without significant alteration of blood flow.
authors.affiliation: Department of Neurosurgery, Chiba Cancer Center Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Namba
authors.forename: T
authors.initials: T
authors.lastname: Irie
authors.forename: K
authors.initials: K
authors.lastname: Fukushi
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tateno
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply* / Q000201:enzymology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003342:Corpus Striatum / Q000201:enzymology; D005947:Glucose / Q000378:metabolism; D007051:Ibotenic Acid / Q000494:pharmacology; D020367:Iofetamine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014726:Vestibular Nuclei / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*
chemical_list: D000662:Amphetamines; D007051:Ibotenic Acid; D020367:Iofetamine; D000110:Acetylcholinesterase; D005947:Glucose