title: Vitamin K supplementation during prophylactic use of cefoperazone in urologic surgery.
abstract: Cefoperazone, an antibiotic commonly used for prophylaxis of infection, has been associated with hypoprothrombinemia and bleeding. To reduce the risk of bleeding, co-administration of vitamin K has been advised. We reassessed the need for vitamin K use in a retrospective analysis of 50 patients undergoing urologic procedures and who had received cefoperazone for three days to prevent infection. Eleven of 50 patients were given vitamin K because of liver or renal disease. Prothrombin time was not elevated in any of the 50 patients analyzed. We conclude that routine use of vitamin K with cefoperazone for perioperative prophylaxis of infection may be unwarranted in patients without identified risk for bleeding.
authors.affiliation: Urology Section, Veterans Affairs Medical Center, East Orange, New Jersey 07019.
authors.forename: S D
authors.initials: SD
authors.lastname: Rockoff
authors.forename: M J
authors.initials: MJ
authors.lastname: Blumenfrucht
authors.forename: R J
authors.initials: RJ
authors.lastname: Irwin
authors.forename: R H
authors.initials: RH
authors.lastname: Eng
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002438:Cefoperazone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D004359:Drug Therapy, Combination; D006801:Humans; D007020:Hypoprothrombinemias / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D011292:Premedication / Q000379:methods / Q000592:standards*; D011517:Prothrombin Time; D012189:Retrospective Studies; D012709:Serum Albumin / Q000032:analysis; D014570:Urologic Diseases / Q000601:surgery*; D014812:Vitamin K / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D012709:Serum Albumin; D014812:Vitamin K; D002438:Cefoperazone; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase