Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin in hyper- and hypo-thyroid rats.
1. Urinary excretion of digoxin-like immunoreactive factor and arginine-vasopressin and other parameters related to salt and water metabolism were studied in hyper- and hypo-thyroid rats after different tests. 2. Urinary excretion of arginine-vasopressin was increased in hyperthyroid and reduced in hypothyroid rats with respect to controls, in response to water deprivation or a hypertonic saline load. 3. Control and hypothyroid rats showed the highest urinary excretion of digoxin-like immunoreactive factor after a hypertonic saline load. However, hyperthyroid rats had the highest urinary levels of digoxin-like immunoreactive factor under normal conditions. 4. From these results it is suggested that: (a) hyper- and hypo-thyroid rats exhibit hyper- and hypo-responsiveness of arginine-vasopressin secretion to osmotic stimuli, respectively; (b) an unidentified digoxin-like immunoreactive factor measured in unextracted rat urine may be related to diuresis and natriuresis in control and hypothyroid rats; however, dissociation between this factor and natriuresis is observed in hyperthyroid rats.
Vargas
F
F
Departamento de Bioquímica, Facultad de Medicina, Granada, Spain.
Baz
M J
MJ
Luna
J D
JD
Andrade
J
J
Jodar
E
E
Haro
J M
JM
D000818:Animals; D001127:Arginine Vasopressin / Q000652:urine*; D001798:Blood Proteins / Q000652:urine*; D002298:Cardenolides; D004077:Digoxin; D006980:Hyperthyroidism / Q000652:urine*; D007037:Hypothyroidism / Q000652:urine*; D007668:Kidney / Q000378:metabolism; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000652:urine*; D013974:Thyroxine / Q000494:pharmacology; D014868:Water Deprivation / Q000502:physiology
D001798:Blood Proteins; D002298:Cardenolides; D012462:Saline Solution, Hypertonic; D012503:Saponins; C034504:digoxin-like factors; D001127:Arginine Vasopressin; D008713:Methimazole; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase; D013974:Thyroxine