Lymphoedema/hypercalcaemia syndrome mediated by parathyroid-hormone-related protein.
A 24-year-old woman presented with a cryptogenic, hypercalcaemic syndrome with metastatic pulmonary calcification and leg and massive breast enlargement and bilateral chylous pleural effusions compatible with a generalised lymphatic abnormality. The patient's serum parathyroid hormone-related protein concentration was very high at a time when she was significantly hypercalcaemic, implying that the hypercalcaemia was mediated by this protein.
Braude
S
S
Royal Brompton, National Heart Hospital, London, UK.
Graham
A
A
Mitchell
D
D
D000328:Adult; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood* / Q000150:complications; D006961:Hyperparathyroidism / Q000175:diagnosis; D008209:Lymphedema / Q000097:blood* / Q000150:complications; D010281:Parathyroid Hormone / Q000097:blood*; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000378:metabolism*; D013577:Syndrome
C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins