title: Genital ulcer disease in men in Durban, South Africa.
abstract: OBJECTIVE
  To study the microbial aetiology of genital ulcer disease (GUD) in men.
  
  
  METHODS
  Microbiological and clinical assessment of genital ulcers in men.
  
  
  METHODS
  City Health sexually transmitted diseases clinic, King Edward VIII Hospital, Durban, South Africa.
  
  
  METHODS
  100 Zulu men with genital ulcers who had not received antibiotics in the previous four weeks.
  
  
  RESULTS
  Syphilis was diagnosed in 42%, chancroid in 22%, donovanosis (granuloma inguinale) in 11%, genital herpes in 10% and lymphogranuloma venereum (LGV) in 6%. No pathogens were identified in 24%. Mixed infections were detected in 14 men, in whom 13 had syphilis. Five men had HIV-1 antibodies. Neisseria gonorrhoeae was isolated from the ulcers and urethra in seven men and from the urethra alone in five. Scabies was diagnosed clinically in eight.
  
  
  CONCLUSIONS
  All the major causes of GUD are prevalent in Zulu men in Durban. Primary syphilis was the commonest and was invariably present in mixed infections. Donovanosis was under-reported and was associated with a long delay before presentation. In this population, genital ulcers other than superficial lesions should be treated with anti-syphilitic therapy and oral antibiotics effective against chancroid and donovanosis.
authors.affiliation: City Health STD Department, King Edward VIII Hospital, Durban, South Africa.
authors.forename: N
authors.initials: N
authors.lastname: O'Farrell
authors.forename: A A
authors.initials: AA
authors.lastname: Hoosen
authors.forename: K D
authors.initials: KD
authors.lastname: Coetzee
authors.forename: J
authors.initials: J
authors.lastname: van den Ende
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002157:Calymmatobacterium / Q000302:isolation & purification*; D005832:Genital Diseases, Male / Q000453:epidemiology / Q000382:microbiology*; D006678:HIV / Q000302:isolation & purification; D006191:Haemophilus ducreyi / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D015995:Prevalence; D012520:Sarcoptes scabiei / Q000302:isolation & purification; D018139:Simplexvirus / Q000302:isolation & purification; D013019:South Africa / Q000453:epidemiology; D014210:Treponema pallidum / Q000302:isolation & purification*; D014456:Ulcer / Q000453:epidemiology / Q000382:microbiology*