title: Synthesis and pharmacological investigation of new N-dimethylpyridyl and N-chloropyridyl substituted arylsuccinimides.
abstract: In the reaction of alpha-phenyl-, alpha-p-chlorophenyl-, alpha-m-chlorophenyl-, alpha-p-bromophenyl and alpha-m-bromophenyl succinic acids with various aminopyridines, N-(dimethylpyridine)-alpha- arylsuccinimides and N-(chloropyridine)-alpha-arylsuccinimides were obtained. The above compounds tested for their CNS activity did not show an anticonvulsant activity.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Medicine, Kraków, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Zejc
authors.forename: J
authors.initials: J
authors.lastname: Obniska
authors.forename: I
authors.initials: I
authors.lastname: Jakowicz
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D011725:Pyridines; D013388:Succinimides