[Activity of marker enzymes and status of the erythrocyte membrane lipid matrix in stress and during its correction using medications].
On the basis of experiments it is shown that chronic stress at the exhaustion stage is followed by activation of lipid peroxidation processes and inhibition of the antioxidant system. Products of peroxide lipid oxidation are accumulated, which in its turn may induce pathological changes in the ratio of different lipid fractions and disturbance in the functional activity of membranes. Under the stress, when a preventive average therapeutic dose of the nicotinic acid derivatives (lithonite, nicogamol, OMI-17) and GABA derivatives (pyracetam, pycamilon) are introduced to rats, activity of marker enzymes remains practically at the control level. A normalizing effect of these drugs on the parameters studied is connected with its expressed membrane-stabilizing effect and non-specific defense of the cytomembranal lipid matrix. Individual peculiarities in pharmacological activity of these drugs are indicated.
Rozhkovskiĭ
Ia V
IaV
Kresiun
V I
VI
D000818:Animals; D015415:Biomarkers; D004798:Enzymes / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism*
D015415:Biomarkers; D004798:Enzymes; D008563:Membrane Lipids; D011619:Psychotropic Drugs; D000254:Sodium-Potassium-Exchanging ATPase
Aktivnost' markernykh fermentov i sostoianie lipidnogo matriksa membranéritrotsitov pri stresse i ego medikamenoznoĭ korrektsii.