[Evaluation of urinary excretion of cyclic guanosine monophosphate in clinical cardiology].
The prognostic importance of levels of urinary excretion of cyclic GMP (cGMPu), the second messenger of the atrial natriuretic factor (ANF) was studied in different cardiac pathologies in 31 patients (19 males and 12 females, average age 66 +/- 15 years) and compared with 31 control subjects of the same age (+/- 4 years) and sex. In the control group, the average cGMPu was 0.35 +/- 0.17 mumoles/24 hours/m2, and, with respect to urinary creatinine, increased with age (r = 0.54, p = 0.002). In the 16 patients with cardiac failure, the cGMPu was very high (1.03 +/- 0.59 mumoles/24 hours/m2, p less than 0.001) without any significant correlation with NYHA functional class although it fell after treatment. After myocardial infarction (8 cases including 3 with cardiac failure), the cGMPu was also high (0.49 +/- 0.33 mumoles/24 hours/m2) but it did not differ significantly from the control values in the 9 atrial arrhythmias without cardiac failure. The cGPMu was related to the cardiothoracic ratio but not to any blood gas parameter or echocardiographic measurement. In conclusion, the cGMPu is more stable and easier to measure than the ANF. It would seem to be a sensitive marker of cardiac failure complicating the most common cardiac pathologies observed in clinical practice.
Baudouy
P Y
PY
Service de cardiologie et médecine interne, hôpital Saint-Michel, Paris.
Abassade
P
P
Valleteau de Moulliac
M
M
Michel
J B
JB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000652:urine; D009320:Atrial Natriuretic Factor / Q000032:analysis; D006152:Cyclic GMP / Q000652:urine*; D005260:Female; D006325:Heart Atria; D006331:Heart Diseases / Q000652:urine*; D006333:Heart Failure / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000652:urine
D009320:Atrial Natriuretic Factor; D006152:Cyclic GMP
Evaluation de l'excrétion urinaire du GMP cyclique en clinique cardiologique.