Evidence for an intrinsic angiotensin system in the canine pancreas.
Increasing evidence suggests an association between hypertension and abnormalities of glucose metabolism. Since components of the renin-angiotensin system exist in a variety of tissues consistent with paracrine actions of the peptide, we sought to determine whether the pancreas contains a local angiotensin system. We report the presence of angiotensinogen messenger (m) RNA, angiotensinogen protein, angiotensin II and high-affinity binding sites for angiotensin II in the canine pancreas. These novel findings establish a foundation for future studies to evaluate whether angiotensin acts as a paracrine regulator of endocrine and/or exocrine functions of the pancreas.
Chappell
M C
MC
Department of Brain and Vascular Research, Cleveland Clinic Foundation, Ohio.
Millsted
A
A
Diz
D I
DI
Brosnihan
K B
KB
Ferrario
C M
CM
D000804:Angiotensin II / Q000032:analysis* / Q000502:physiology; D000808:Angiotensinogen / Q000032:analysis / Q000235:genetics; D000809:Angiotensins / Q000032:analysis; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D004285:Dogs; D005947:Glucose / Q000378:metabolism; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D010179:Pancreas / Q000737:chemistry* / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis
D000809:Angiotensins; D012333:RNA, Messenger; D000808:Angiotensinogen; D000804:Angiotensin II; D005947:Glucose