title: GABAA receptors are differentially sensitive to zinc: dependence on subunit composition.
abstract: GABAA receptors with different subunit composition, were expressed in kidney cells and studied by whole cell recording. Expressed GABAA receptors were differentially sensitive to inhibition by zinc; receptors which lacked the gamma subunit were inhibited by zinc. Embryonic neurons also exhibited zinc-sensitive GABA responses, in contrast to adult neurones. This developmentally-sensitive aspect of GABAA receptor pharmacology may be partly dependent on expression of the gamma subunit.
authors.affiliation: School of Pharmacy, Department of Pharmacology, London.
authors.forename: T G
authors.initials: TG
authors.lastname: Smart
authors.forename: S J
authors.initials: SJ
authors.lastname: Moss
authors.forename: X
authors.initials: X
authors.lastname: Xie
authors.forename: R L
authors.initials: RL
authors.lastname: Huganir
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000032:analysis / Q000187:drug effects*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D011963:Receptors, GABA-A; D015032:Zinc