Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8.
The host range of retroviruses is determined primarily by the presence of specific receptors on target cells which are recognized by the retroviral envelope glycoprotein. Somatic cell hybrids have been used to determine the chromosomal locations of several retroviral receptors in mice prior to their molecular cloning. Here we report that by using human-Chinese hamster somatic cell hybrids and a retroviral vector, we have mapped the receptor for the amphotropic murine leukemia virus to the pericentromeric region of human chromosome 8.
Garcia
J V
JV
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
Jones
C
C
Miller
A D
AD
D016475:3T3 Cells; D000818:Animals; D016466:CHO Cells; D002503:Centromere / Q000502:physiology*; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D006224:Cricetinae; D005822:Genetic Vectors; D006801:Humans; D006822:Hybrid Cells; D006922:Hylobates; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000502:physiology*; D051379:Mice; D011991:Receptors, Virus / Q000235:genetics*; D012190:Retroviridae / Q000235:genetics / Q000502:physiology*; D050611:Sodium-Phosphate Cotransporter Proteins, Type III
D011991:Receptors, Virus; C493589:SLC20A2 protein, human; D050611:Sodium-Phosphate Cotransporter Proteins, Type III