Biochemical studies on the antidiarrhoeal effects of Cauvery-100, an ayurvedic formulation, in rats.
Diarrhoea is a common gastrointestinal disorder which is a state of fluid and ion loss from the gut. Cauvery-100, an Ayurvedic formulation has been used in this study for the treatment of diarrhoea. Diarrhoea was induced in experimental rats by oral administration of castor oil. The increased gastrointestinal motility in diarrhoea was brought back to near normal levels on the treatment of Cauvery-100. The activities of the enzymes alkaline phosphatase, total ATPase and Na+,K(+)-ATPase were decreased in the diarrhoeal group and was brought back to near normal levels in the treated group. The serum levels of sodium and potassium were decreased in the diarrhoeal group and brought back to normal levels in the treated group. Prior treatment of the drug Cauvery-100 did not induce diarrhoea on administration of castor oil, suggesting the protective influence of the drug on the gastrointestinal tract.
Manonmani
S
S
Department of Biochemistry, University of Madras.
William
S
S
Subramanian
S
S
Govindasamy
S
S
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000930:Antidiarrheals / Q000737:chemistry / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D007422:Intestines / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D051381:Rats; D012964:Sodium / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000930:Antidiarrheals; C073389:Cauvery-100; D010936:Plant Extracts; D012964:Sodium; D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium