Serine/threonine phosphatases in the nervous system.
The cloning and sequence determination of cDNAs encoding different types of serine/threonine protein phosphatases has provided a molecular basis for the protein phosphatase classification proposed by Ingebritsen and Cohen. Each of the phosphatases, phosphatase-1, -2A, -2B and -2C, exists as multiple isozymes raising the possibility that isozymes selectively expressed in different tissues may perform specific functions. The recent discovery of potent toxin inhibitors specific for protein phosphatase-1 and -2A will undoubtedly play an important role in the elucidation of the role of these enzymes in neuronal function.
Stemmer
P
P
Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Klee
C B
CB
D000818:Animals; D006801:Humans; D009420:Nervous System / Q000201:enzymology*; D009424:Nervous System Physiological Phenomena; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D054645:Protein Phosphatase 1; D012694:Serine / Q000378:metabolism*; D013912:Threonine / Q000378:metabolism*
D013912:Threonine; D012694:Serine; D010749:Phosphoprotein Phosphatases; D054645:Protein Phosphatase 1