title: [Tumor suppressor genes: occurrence, significance and function].
abstract: Tumor-suppressor-genes were detected by DNA-analysis of childhood tumors. A homozygous deletion or mutation of these genes is closely associated with different malignant tumors. Tumor-suppressor-genes seem to play an important role in cellular development and differentiation. The understanding of this pathomechanism in cancerogenesis is most important for calculating a genetic risk for tumor development.
authors.affiliation: Universitäts-Kinderklinik Würzburg.
authors.forename: W
authors.initials: W
authors.lastname: Scheurlen
authors.forename: H W
authors.initials: HW
authors.lastname: Kreth
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D002872:Chromosome Deletion; D005134:Eye Neoplasms / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics; D009396:Wilms Tumor / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor
vernacular_title: Tumorsuppressorgene: Vorkommen, Bedeutung und Funktion.