title: Identification of a novel class of highly potent sigma ligands related to the kappa-selective agonist U50,488.
authors.affiliation: Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892.
authors.forename: L A
authors.initials: LA
authors.lastname: Radesca
authors.forename: B R
authors.initials: BR
authors.lastname: deCosta
authors.forename: W D
authors.initials: WD
authors.lastname: Bowen
authors.forename: L J
authors.initials: LJ
authors.lastname: DiPaolo
authors.forename: K C
authors.initials: KC
authors.lastname: Rice
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics; D000818:Animals; D007276:Injections, Intraventricular; D008024:Ligands; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects*; D017480:Receptors, sigma; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D008024:Ligands; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017480:Receptors, sigma; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer