Myelo-optic neuropathy caused by aconitine in rabbit model.
A single dose of aconitine (0.6 mg/kg), the principal constituent of aconite, was administered intraperitoneally in order to evaluate its toxic effects on the visual system of a rabbit model. The typical pattern in which the alteration in the visual evoked potential occurred after an aconitine injection consisted of a delay in the onset and peak latency, and a reduction in the amplitude. Histopathologically, there was damage to the myelin sheath of the visual pathway, spinal cord and peripheral nerves. These findings suggest that a toxic dose of aconitine may cause myelo-optic neuropathy in rabbits.
Kim
S H
SH
Department of Ophthalmology, Kyung-Pook National University Hospital, Taegu, Korea.
Kim
S D
SD
Kim
S Y
SY
Kwak
J S
JS
D000157:Aconitine / Q000633:toxicity*; D000818:Animals; D003711:Demyelinating Diseases / Q000139:chemically induced* / Q000473:pathology; D005074:Evoked Potentials, Visual / Q000187:drug effects; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000473:pathology; D011817:Rabbits; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000473:pathology
D000157:Aconitine