cAMP and vascular action of endothelin.
Endothelin, a potent vasoconstricting peptide, induced maximal contraction of the rat tail artery within 3 min of administration. Endothelin also caused a dose-dependent decrease in tissue levels of cAMP. Concentrations of cAMP decreased about 60% 1 min after endothelin (10(-8) M) administration, but returned to basal levels in 5 min. By contrast, tissue levels of cGMP were not changed by endothelin. Modulation of cAMP production may provide one mechanism for the vascular action of endothelin.
Yang
M C
MC
Department of Medical Research, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Tu
M S
MS
Chou
C K
CK
Hong
C Y
CY
Kuo
J S
JS
D000818:Animals; D001158:Arteries / Q000187:drug effects* / Q000378:metabolism; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013623:Tail / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*
D016232:Endothelins; D000242:Cyclic AMP; D006152:Cyclic GMP