[Donor allopurinol treatment improves organ preservation of the kidney also when using UW solution].
Kidney function following hypothermic preservation with Eurocollins (EC) was previously shown to be improved by donor treatment with Allopurinol (AP) [1]. The University of Wisconsin organ preservation solution (UW), however, contains Allopurinol (1 mM). A syngeneic rat kidney transplant model was used to investigate concurrent Allopurinol donor-pretreatment (40 mg/kg b.w.). Kidney graft function resulted to be improved by AP pretreatment following organ preservation with both EC or UW as evidenced by significant reduction in serum creatinine values. On day two following transplantation the respective serum creatinine values (mumol/l) with and without AP-pretreatment were 424 +/- 39 and 662 +/- 25 for EC, and 259 +/- 48 and 387 +/- 48 for UW organ preservation. Furthermore survival- and histology-data were also superior for recipients of kidney grafts from AP-pretreated donors. We conclude that Allopurinol concentration in the UW solution might be to low or that adding AP into an organ storage solution is not the best application modality.
Marx
A
A
Departement Chirurgie, Universität, Kantonsspital Basel.
Heberer
M
M
Jörgensen
J
J
Gürke
L
L
Mihatsch
M
M
Landmann
J
J
D000241:Adenosine; D000493:Allopurinol / Q000008:administration & dosage*; D000818:Animals; D005978:Glutathione; D006085:Graft Survival / Q000187:drug effects*; D006982:Hypertonic Solutions; D007328:Insulin; D016030:Kidney Transplantation; D009926:Organ Preservation; D019188:Organ Preservation Solutions; D011292:Premedication; D011887:Raffinose; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D014019:Tissue Donors
C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; D007328:Insulin; D019188:Organ Preservation Solutions; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose
Allopurinol-Spenderbehandlung verbessert die Organ-konservierung der Niere auch bei Verwendung der UW-Lösung.