Recognition of transformed cells by autologous lymphocytes: a review.
The studies on the T cell response against EBV carrying B cells demonstrated its high power in vivo. Malignancies with phenotypes similar to the in vitro transformed B cells occur only in severely immunosuppressed patients. Presently the goal of the studies is the identification of the antigens recognised by T lymphocytes and their association with the various HLA alleles. The studies on human sarcomas and carcinomas still struggle with the demonstration of specific T cell responses and the characterisation of the target molecules on the tumor cells. The main goals are the possibilities to readminister tumor reactive T cells for therapeutic purposes and the use of in vitro assays for guidance of the design and schedule for immunotherapy protocols.
Klein
E
E
Department of Tumor Biology, Karolinska Institutet, Stockholm, Sweden.
Kedar
E
E
Wang
P
P
Vánky
F
F
D001402:B-Lymphocytes / Q000276:immunology; D002461:Cell Line, Transformed; D002999:Clone Cells / Q000276:immunology; D004195:Disease Models, Animal; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014182:Transplantation, Autologous