title: Multicatalytic proteinase is present in Lewy bodies and neurofibrillary tangles in diffuse Lewy body disease brains.
abstract: A non-lysosomal multicatalytic proteinase (MCP) is immunohistochemically visualized in Lewy bodies and loosely arranged globose tangles but not in the majority of compact neurofibrillary tangles in brains with cortical diffuse Lewy body disease. Virtually all Lewy bodies are immunoreactive to MCP, exhibiting various staining patterns where they are moderately diffuse, intense in the central core or intense in the peripheral rim. MCP may be involved in the formation of these inclusions.
authors.affiliation: National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kwak
authors.forename: T
authors.initials: T
authors.lastname: Masaki
authors.forename: S
authors.initials: S
authors.lastname: Ishiura
authors.forename: H
authors.initials: H
authors.lastname: Sugita
mesh_terms: D000368:Aged; D001921:Brain / Q000201:enzymology*; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009097:Multienzyme Complexes / Q000378:metabolism*; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D010300:Parkinson Disease / Q000201:enzymology*; D046988:Proteasome Endopeptidase Complex; D014018:Tissue Distribution; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex