title: [Hydrophobic parameters of certain coumarins in studies of structure-activity relationship].
abstract: The hydrophobic nature of drugs, very important feature in determination of biological activity, is in Hansch's approach characterized by the logarithm of partition coefficient (log P) determined in n-octanol -water system, or calculated from hydrophobic constants pi (Hansch) or f (Rekker). Those as well as other parameters of hydrophobicity (log k'w, RMw or chi-connectivity index) were correlated with the spasmolytic and cytostatic activity of some coumarins.
authors.affiliation: Katedra Chemii Nieorganicznej i Analitycznej Akademii Medycznej, Lublinie.
authors.forename: M L
authors.initials: ML
authors.lastname: Bieganowska
authors.forename: K
authors.initials: K
authors.lastname: Głowniak
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D010276:Parasympatholytics / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D010276:Parasympatholytics
vernacular_title: Parametry hydrofobowości niektórych kumaryn w badaniach zalezności struktura-aktywność.