Prognostic factors in survival of bladder cancer.
Clinical and pathologic data of 36 patients with transitional cell carcinoma of the bladder were investigated to determine the significance on patient survival of these factors: pathologic grade and stage; the immunohistochemistry of eight cell and tumor markers; nuclear DNA flow cytometric parameters; and patient smoking status. The bivariate and multivariate statistical analysis significantly correlated patient survival rates with the immunohistochemical expression of blood group, isoantigens A (P less than 0.05), O(H) (P = 0.001), the oncogene-related protein ORP-p21 (P less than 0.05), the pathologic grade and stage (P = 0.002), and the tumor DNA ploidy (P less than 0.05). Smoking status correlated aneuploidy (P less than 0.05) and tumor expression of ORP-p21 (P less than 0.05) with the patient survival rate. Despite the relatively small number of patients in this study, the results suggest that the clinicopathologic variables are significant factors in survival of bladder cancer.
Lopez-Beltran
A
A
Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York.
Croghan
G A
GA
Croghan
I
I
Huben
R P
RP
Mettlin
C
C
Gaeta
J F
JF
D000017:ABO Blood-Group System; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000032:analysis; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007519:Isoantigens / Q000032:analysis; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D018396:Mucin-1; D009367:Neoplasm Staging; D015689:Oncogene Protein p21(ras) / Q000032:analysis; D011003:Ploidies; D011237:Predictive Value of Tests; D011379:Prognosis; D012907:Smoking / Q000009:adverse effects; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology
D000017:ABO Blood-Group System; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D007519:Isoantigens; D008562:Membrane Glycoproteins; D018396:Mucin-1; C057387:mucinous carcinoma-associated antigen; D015689:Oncogene Protein p21(ras)