[Syntheses of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[(4-P-nitrobenzol)-1- piperazinyl] quinoline-3-carboxylic acid and its analogues].
Syntheses of thirteen new compounds of 1-ethyl-6-flouro-1, 4-dihydro-4-oxo-7-[(4-p-nitrobenzoyl)1-piperazinyl] quinoline-3-carboxylic acid and its analogues are reported. The structures were determined by IR, 1HNMR and elemental analysis. Four compounds have been subjected to antibacterial activity tests in vitro. Compound I1 was shown to have significant activity.
Chen
H C
HC
Department of Chemistry, Zhengzhou University.
Guo
Y C
YC
Lu
D R
DR
D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D024841:Fluoroquinolones; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C071823:1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-((4-p-nitrobenzol)-1-piperazinyl)quinoline-3-carboxylic acid