[Monoaminergic receptors and hypotheses of the mechanisms of action of 2nd generation antidepressive agents].
The inhibition of the serotonin and/or noradrenalin reuptake is often given as the mechanism of action of antidepressants. This may be true but it's certainly wrong! The diversity of chemical structure and pharmacological profiles of second generation antidepressants shows that the biochemical property that is the most often found is the inhibition of the uptake of 5-HT and/or NA. The difference of the kinetics between the inhibition of the monoamine reuptake and the antidepressant effect is only one of the reasons to believe that the real mechanism of their antidepressant action is elsewhere. The different hypotheses that have been proposed will be examined.
Briley
M
M
Centre de Recherche Pierre Fabre, Castres.
Moret
C
C
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D015306:Biogenic Monoamines / Q000378:metabolism; D015283:Citalopram / Q000494:pharmacology; D003521:Cyclopropanes / Q000494:pharmacology; D015536:Down-Regulation; D007031:Hypothalamus / Q000378:metabolism; D000078764:Milnacipran; D009638:Norepinephrine / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects
D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D003521:Cyclopropanes; D011956:Receptors, Cell Surface; D011985:Receptors, Serotonin; D015283:Citalopram; D000078764:Milnacipran; D009638:Norepinephrine
Récepteurs monoaminergiques et hypothèses des mécanismes d'action des antidépresseurs de seconde génération.