Cellular retinoic acid-binding protein type 2 mRNA is overexpressed in human psoriatic skin as shown by in situ hybridization.
In situ hybridization with full length mouse cellular retinoic acid-binding protein type 1 and cellular retinoic acid-binding protein type 2 cDNA derived RNA probes showed overexpression of cellular retinoic acid-binding protein type 2 mRNA in lesional hyperplastic psoriatic skin whereas cellular retinoic acid-binding protein type 1 mRNA was undetectable. This suggests that the previously reported increase of cellular retinoic acid-binding protein in psoriatic epidermis corresponds to increased translation of cellular retinoic acid-binding protein type 2 gene. Cellular retinoic acid-binding protein types 1 and 2 mRNAs were not detectable in normal epidermis; however, type 2 message was detected in non-hyperplastic, non-lesional skin of psoriatic patients thus before altered epidermal differentiation and hyperplasia are morphologically detectable.
Didierjean
L
L
Clinique de Dermatologie, Hôpital Cantonal Universitaire, Genève, Switzerland.
Durand
B
B
Saurat
J H
JH
D016375:Antisense Elements (Genetics); D002352:Carrier Proteins / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D009693:Nucleic Acid Hybridization; D011565:Psoriasis / Q000235:genetics* / Q000473:pathology; D015347:RNA Probes; D012333:RNA, Messenger / Q000235:genetics*; D018168:Receptors, Retinoic Acid; D014212:Tretinoin / Q000378:metabolism*
D016375:Antisense Elements (Genetics); D002352:Carrier Proteins; D015347:RNA Probes; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; D014212:Tretinoin