title: Effects of corticosterone and microgravity on inflammatory cell production of superoxide.
abstract: In this investigation we studied the effects of corticosterone and microgravity on Propionibacterium acnes-induced inflammatory cells ability to produce superoxide (O2-). We found in vitro and in vivo exposure of murine peritoneal inflammatory cells to corticosterone did not inhibit the O2- response. We also found that in microgravity P. acnes-induced inflammatory cells were capable of producing four times as much O2- as at 1g. Therefore, neither corticosterone nor microgravity experienced during parabolic flight prevents an O2- response by inflammatory cells.
authors.affiliation: Division of Biology, Kansas State University, Manhattan 66506.
authors.forename: S D
authors.initials: SD
authors.lastname: Fleming
authors.forename: L S
authors.initials: LS
authors.lastname: Edelman
authors.forename: S K
authors.initials: SK
authors.lastname: Chapes
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D005260:Female; D006112:Gravitation; D007249:Inflammation / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009504:Neutrophils / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
chemical_list: D013481:Superoxides; D003345:Corticosterone