title: [Synthesis of (+/-)-edulinine analogues].
abstract: The natural product, edulinine (I), possesses analgesic, anaesthetic and anticonvulsant activities on the central nervous system. In this paper we report that a series of edulinine analogues IV, V were synthesized and screened in mice according to methods of Topliss and Austel quantitative drug design. In preliminary pharmacological tests a number of synthesized compounds showed central depressant activities stronger than edulinine.
authors.affiliation: Shanghai Institute of Materia Medica, Academia Sinica.
authors.forename: L G
authors.initials: LG
authors.lastname: Qian
authors.forename: K J
authors.initials: KJ
authors.lastname: Gu
authors.forename: R Y
authors.initials: RY
authors.lastname: Ji
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D015363:Quinolones / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000700:Analgesics; D015363:Quinolones; C060993:edulinine