Synthesis and antienzymic activity of two new angiotensin converting enzyme inhibitors.
Two new analogs of captopril were synthesized. Inhibition of angiotensin converting enzyme (ACE) by these compounds in vitro and in vivo was determined using fluorimetric method. The obtained compounds were much weaker ACE inhibitors than captopril.
Dudkiewicz
J
J
Institute for Drug Research and Control, Warszawa, Poland.
Suska
T
T
Tautt
J
J
Paruszewski
R
R
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013050:Spectrometry, Fluorescence
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D007703:Peptidyl-Dipeptidase A