Effects of serotonin1-like receptor agonists on autonomic neurotransmission.
Serotonin1A receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin and 10-methyl-11-hydroxyaporphine, inhibited electrical stimulation-induced contraction of the guinea-pig ileum. These agonists also inhibited the pressor and tachycardiac responses to low frequency (0.25 Hz) but not to high frequency (2.0 Hz) electrical stimulation of the sympathetic nervous system in pithed rats. Serotonin1B receptor agonist RU 24969 inhibited pressor and tachycardiac responses to both low and high frequencies of stimulation in pithed rats. In the cat nictitating membrane, serotonin1A receptor agonists did not alter contractions elicited by electrical stimulation (0.1-3.0 Hz). Serotonin not only contracted the cat nictitating membrane but also facilitated contractile responses to low frequency (0.1-1.0 Hz) stimulation. The contractile effect of serotonin in the cat nictitating membrane was blunted by bretylium, methysergide, and ketanserin, but not by metoclopramide. The facilitatory effect of serotonin was antagonized by methysergide, but not by ketanserin, pindolol, propranolol, or metoclopramide. These results suggest that serotonin1A receptors modulate autonomic neurotransmission in the guinea-pig ileum and pithed rats, but not in the cat nictitating membrane. Serotonin contracts the cat nictitating mebrane via serotonin2 subtypes, while facilitating stimulated contractile responses through the serotonin1-like receptors.
Park
K H
KH
Department of Pharmacology, College of Medicine and Pharmacy, University of Iowa City 52242.
Long
J P
JP
Cannon
J G
JG
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000818:Animals; D001060:Aporphines / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects; D001949:Bretylium Compounds / Q000494:pharmacology; D002415:Cats; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology; D008297:Male; D009541:Nictitating Membrane / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology
D001060:Aporphines; D001949:Bretylium Compounds; D007211:Indoles; D011985:Receptors, Serotonin; D013764:Tetrahydronaphthalenes; C054813:PM 1000; C025145:5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole; D012701:Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C045166:bretylium