title: Disseminated infection of herpes simplex virus with fulminant hepatitis in a healthy adult. A case report.
abstract: An autopsy case of fulminant hepatitis caused by herpes simplex virus type 1 in a healthy adult is presented. The clinical course was characterized by hepatic failure, disseminated intravascular coagulation and acute renal failure. Many small ulcerations were present in the tongue and tonsils, and there were foci of hemorrhagic necrosis in the liver. Herpes simplex viral antigen was identified in the liver, tonsils, spleen, tongue, pharynx, larynx, esophagus, stomach, intestine, adrenal glands, and lymph nodes with immunohistochemical staining using antibodies to herpes simplex virus type 1. The electron microscopic examination revealed many virions in the hepatocytes. Herpes simplex virus was isolated from the liver, and viral DNA, which had some distinctive features of herpes simplex virus type 1, was examined. We discuss possible reasons for this opportunistic infection occurring in a healthy adult.
authors.affiliation: Department of Pathology, Medical College of Oita, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: S
authors.initials: S
authors.lastname: Akizuki
authors.forename: H
authors.initials: H
authors.lastname: Sakaoka
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Terao
mesh_terms: D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D006505:Hepatitis / Q000382:microbiology* / Q000473:pathology; D006561:Herpes Simplex / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000382:microbiology / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009336:Necrosis; D015183:Restriction Mapping; D018139:Simplexvirus / Q000235:genetics / Q000302:isolation & purification* / Q000648:ultrastructure
chemical_list: D004279:DNA, Viral