Drug testing for activity against varicella-zoster virus in hairless guinea pigs.
Inoculation of congenitally hairless guinea pigs with varicella-zoster virus (VZV) (Oka strain) results in a self-limited exanthematous infection analogous to varicella in children. Administration of acyclovir or 6-methoxypurine arabinoside modified the course of infection. This model should facilitate pre-clinical testing of putative anti-VZV agents.
Myers
M G
MG
Division of Infectious Diseases, Children's Hospital Research Foundation, Cincinnati, OH 45229-2899.
Stanberry
L R
LR
D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002675:Child, Preschool; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005076:Exanthema / Q000150:complications / Q000188:drug therapy; D006168:Guinea Pigs; D006562:Herpes Zoster / Q000150:complications / Q000188:drug therapy*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D006801:Humans
D000998:Antiviral Agents; D000212:Acyclovir