Role of calcium in toxic and programmed cell death.
An uncontrolled and sustained increase in cytosolic Ca2+ concentration has been implicated as an early event in the development of anoxic or toxic cell injury. More recently it has become clear that an elevation of cytosolic Ca2+ is also involved in programmed cell death in the immune system. Here, we review some of our recent studies and provide further evidence for the role of Ca2+ in cell killing.
Orrenius
S
S
Department of Toxicology, Karolinska Institutet, Stockholm, Sweden.
McConkey
D J
DJ
Nicotera
P
P
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology*; D003599:Cytoskeleton / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004720:Endonucleases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D006706:Homeostasis; D010740:Phospholipases / Q000378:metabolism
D004720:Endonucleases; D010740:Phospholipases; D010450:Endopeptidases; D002118:Calcium