title: [Effect of ceruloplasmin conformation on its activity: significance for clinical analysis].
abstract: Conformational properties of ceruloplasmin were studied immediately in blood serum of healthy volunteers, patients with tuberculosis, with pulmonary cancer, with pneumonia and with Wilson-Konovalov disease. The glycoprotein conformation was found to depend on the volunteer physiological state and/or available pathology. The ceruloplasmin conformation and status of its copper-containing sites of the I type affected the enzyme oxidase properties and hence routine colorimetric procedures require some corrections for estimation of ceruloplasmin concentration and activity in blood serum.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Taras'ev
authors.forename: E P
authors.initials: EP
authors.lastname: Saburenkova
authors.forename: I I
authors.initials: II
authors.lastname: Dantsig
authors.forename: K A
authors.initials: KA
authors.lastname: Moshkov
authors.forename: V V
authors.initials: VV
authors.lastname: Ryl'kov
mesh_terms: D002570:Ceruloplasmin / Q000378:metabolism*; D003124:Colorimetry; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood; D008297:Male; D011014:Pneumonia / Q000097:blood; D011487:Protein Conformation; D012016:Reference Values
chemical_list: D006023:Glycoproteins; D002570:Ceruloplasmin
vernacular_title: O vliianii konformatsii tseruloplazmina na ego aktivnost': znachenie dlia klinicheskogo analiza.