Small cell carcinoma of the uterine cervix showing Cushing's syndrome caused by ectopic adrenocorticotropin hormone production.
A uterine cervical cancer is reported in a woman who developed Cushing's syndrome. The tumor measured 1.3 x 0.7 cm, and was a pure small cell carcinoma, identical to that in the lung. The primary tumor cells showed argyrophilia with Grimelius staining and reacted positively to the anti-chromogranin antibody. Clinically, the neoplasm behaved in an aggressive manner in spite of adjuvant chemotherapy and radiotherapy, and the patient died of widespread metastasis. Cushing's syndrome was noted after the occurrence of liver metastasis with an elevation of the serum adrenocorticotropin hormone (ACTH) level. At autopsy, metastatic tumor cells from the liver reacted immunohistochemically positively not only to anti-ACTH but also to antichromogranin, anti-gastrin and anti-calcitonin antibodies. This is the first report of an immunohistochemical analysis of, and comparison of primary and metastatic sites in cervical carcinoma showing Cushing's syndrome.
Iemura
K
K
Department of Gynecology, National Cancer Center Hospital, Tokyo.
Sonoda
T
T
Hayakawa
A
A
Abe
S
S
Nemoto
N
N
Adachi
I
I
Tsuda
H
H
Teshima
S
S
D000182:ACTH Syndrome, Ectopic / Q000209:etiology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D018288:Carcinoma, Small Cell / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D003480:Cushing Syndrome / Q000209:etiology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
D000324:Adrenocorticotropic Hormone