Transplantation of fetal cells.
Cellular transplantation is an attractive alternative to whole-organ transplantation when only a discrete function of the organ is deficient. Early fetal donor cells have an advantage because they engraft readily and do not cause graft-versus-host disease. Similarly, the fetus is an ideal recipient of allogeneic fetal cells as it is incapable of rejecting them early in gestation. This review presents the theoretical rationale, recent research advances, and clinical implications for adults with diabetes mellitus and Parkinson's disease; we also describe in utero transplantation of fetal hematopoietic stem cells and hepatocytes for the treatment of inherited hematologic and hepatic deficiencies, as well as the use of fetal islet cells and dopamine-producing cells to treat postnatal conditions.
Crombleholme
T M
TM
Department of Surgery, University of California, San Francisco 94143-0570.
Langer
J C
JC
Harrison
M R
MR
Zanjani
E D
ED
D000818:Animals; D002678:Chimera; D004298:Dopamine / Q000378:metabolism; D004992:Ethics, Medical; D016332:Fetal Tissue Transplantation / Q000639:trends; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology / Q000196:embryology; D008099:Liver / Q000196:embryology; D009474:Neurons / Q000378:metabolism / Q000637:transplantation; D011323:Primates; D012756:Sheep; D014162:Transfection
D004298:Dopamine