Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation.
Among 289 pregnancies in which chorion villus sampling (CVS) was carried out at 56-66 days' gestation, 5 babies with severe limb abnormalities were subsequently identified. 4 had oromandibular-limb hypogenesis syndromes, and the other had a terminal transverse limb reduction defect. This high incidence raises the possibility that CVS was an aetiological factor for these developmental anomalies.
Firth
H V
HV
Department of Medical Genetics, Churchill Hospital, Oxford, UK.
Boyd
P A
PA
Chamberlain
P
P
MacKenzie
I Z
IZ
Lindenbaum
R H
RH
Huson
S M
SM
D000015:Abnormalities, Multiple / Q000209:etiology*; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D017880:Limb Deformities, Congenital; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013577:Syndrome