title: New insights into mechanisms of oxyradical and neutrophil mediated lung injury.
abstract: Acute lung injury in rats developing after systemic complement activation or deposition of IgG immune complexes is complement-dependent and oxygen radical-mediated. Recent findings have shown that a soluble complement receptor (sCR1) is capable of attenuating injury. Additional studies have also demonstrated requirements for the cytokines, TNF alpha, and for L-arginine derived products in lung injury that follows deposition of IgG immune complexes.
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor.
authors.forename: P A
authors.initials: PA
authors.lastname: Ward
authors.forename: M S
authors.initials: MS
authors.lastname: Mulligan
mesh_terms: D000818:Animals; D001120:Arginine / Q000502:physiology; D004730:Endothelium, Vascular / Q000276:immunology; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007105:Immune Complex Diseases / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D010100:Oxygen / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000276:immunology; D051381:Rats; D011951:Receptors, Complement / Q000502:physiology; D012128:Respiratory Distress Syndrome / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D006878:Hydroxides; D011951:Receptors, Complement; D014409:Tumor Necrosis Factor-alpha; D017665:Hydroxyl Radical; D001120:Arginine; D010100:Oxygen