The safety of corticosteroid therapy in Crohn's disease with an abdominal mass.
Steroid therapy is often avoided in the Crohn's disease patient with a palpable abdominal mass, for fear of dissemination of infection, should the mass prove to contain an abscess. In the present study, 24 patients with Crohn's disease and a palpable abdominal mass were treated with high dose steroids. In 15, the mass resolved completely and, in another nine, it decreased in size by at least 50%. Fourteen of 24 patients eventually required resection for persistence or recurrence of Crohn's disease activity with or without the abdominal mass, but in all the operation was performed electively. At least eight patients never required resection during a mean follow-up period of 40 months. In 13 patients, the mass was later proved to actually contain an abscess cavity. No complications attributable to steroid therapy were seen in either the operative or nonoperative group. Clinicians should not fear using high dose ACTH/corticosteroids to treat severe Crohn's disease with an abdominal mass, if indicated, as it is both safe and effective whether an abscess cavity is present or not.
Felder
J B
JB
Department of Medicine, Lenox Hill Hospital, New York, New York.
Adler
D J
DJ
Korelitz
B I
BI
D000038:Abscess / Q000150:complications*; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000324:Adrenocorticotropic Hormone / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002648:Child; D000075202:Contraindications; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007410:Intestinal Diseases / Q000150:complications; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D011241:Prednisone; D006854:Hydrocortisone