[The effect of leu-enkephalin and its synthetic analog on the behavior of rats with different sensitivities to ethanol].
Leu-enkephalin and its analogue N 171 increased the pain thresholds and reduced the affective aggression in unrestrained male rats. The N 171 manifested a greater analgesic and antiaggresiogenic effect, particularly in i.p. administration. Preliminary administration of peptides manifested a more obvious effect in alcohol-preferring rats under painful stress.
Liashev
Iu D
IuD
Sever'ianova
L A
LA
Bobyntsev
I I
II
D000428:Alcohol Drinking / Q000503:physiopathology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004198:Disease Susceptibility / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D010146:Pain / Q000503:physiopathology; D051381:Rats; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D013312:Stress, Physiological / Q000503:physiopathology
D004743:Enkephalin, Leucine
Vliianie leĭ-énkefalina i ego sinteticheskogo analoga na povedenie krys s razlichnoĭ chuvstvitel'nost'iu k étanolu.