Sexual dimorphism of stress-induced changes in renal peripheral benzodiazepine receptors in rat.
Adult male and female rats were exposed to either inescapable shock or no treatment. In vitro [3H]Ro 5-4864 (4'-chlorodiazepam) binding (1 nM) to peripheral benzodiazepine receptors (PRB) in both CNS and peripheral tissues indicated no gender differences in olfactory bulb, heart, lung or adrenal gland but a significant effect was observed in renal tissue. Female rats showed an attenuated stress-induced reduction (23%) in PBR in comparison to males (55%). This difference was shown to be an alteration of Bmax and not kD by Scatchard analysis. These data are the first demonstration of a sexual dimorphism in environmentally-induced alterations in PBR.
Drugan
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RC
Schrier Research Laboratory, Department of Psychology, Brown University, Providence, RI 02912.
Holmes
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PV
Stringer
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AP
D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*; D012727:Sex Characteristics; D013312:Stress, Physiological / Q000378:metabolism*
D001570:Benzodiazepinones; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam