title: [Combination of transarterial chemoembolization and endocrine therapy for liver metastases of breast cancer].
abstract: Nine patients with multiple metastases including liver from breast cancer were treated with transarterial chemoembolization through hepatic artery using 40-50 mg of 4'-epi-adriamycin and Lipiodol, followed by 800-1,200 mg/day of medroxyprogesterone acetate. Of 9 patients thus treated, there were 4 partial response (44%), 2 no change and 3 progressive disease. Duration of disease control ranged from 4 to 46 months (mean 24.5 months). Seven out of 9 patients died within 6 to 37 months (mean 15.3 months) after diagnosis of liver metastases. The 3- and 5-year survival rates were 45% and 11%, respectively. We conclude that this therapy is a useful treatment modality for controlling liver metastases of breast cancer.
authors.affiliation: Dept. of Surgery, Osaka Teishin Hospital.
authors.forename: E
authors.initials: E
authors.lastname: Yayoi
authors.forename: M
authors.initials: M
authors.lastname: Nishihara
authors.forename: H
authors.initials: H
authors.lastname: Miyoshi
authors.forename: K
authors.initials: K
authors.lastname: Okahara
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Hasuike
authors.forename: J
authors.initials: J
authors.lastname: Furukawa
authors.forename: M
authors.initials: M
authors.lastname: Naoi
authors.forename: N
authors.initials: N
authors.lastname: Takata
authors.forename: H
authors.initials: H
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D004317:Doxorubicin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007459:Iodized Oil / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008525:Medroxyprogesterone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017258:Medroxyprogesterone Acetate; D008875:Middle Aged
chemical_list: D007459:Iodized Oil; D004317:Doxorubicin; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone