title: [Determination of autoantibodies to thyrotropin receptors in patients with diffuse toxic goiter].
abstract: The blood level of antithyroid autoantibodies to TSH receptors was determined in patients with toxic goiter (TG) before and during antithyroid therapy using two biological methods (by the increment in the cAMP level in slices and primary monolayer culture of human thyroid cells) and a radioreceptor method (by inhibition of TSH binding with its receptors from the animal thyroid). Comparison of the results of these three methods has shown that all methods are almost equally valuable for diagnosis of new cases of TG. However the biological method was shown to be more sensitive and informative with regard to predicting the time of immunological remission during antithyroid therapy.
authors.forename: N A
authors.initials: NA
authors.lastname: Mkrtumova
authors.forename: S I
authors.initials: SI
authors.lastname: Kraĭnova
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Sviridenko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Baslerova
authors.forename: G F
authors.initials: GF
authors.lastname: Aleksandrova
authors.forename: E N
authors.initials: EN
authors.lastname: Bazarova
authors.forename: V I
authors.initials: VI
authors.lastname: Bogdanov
authors.forename: V I
authors.initials: VI
authors.lastname: Kandror
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D006042:Goiter / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D011869:Radioligand Assay; D011989:Receptors, Thyrotropin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D011989:Receptors, Thyrotropin; D000242:Cyclic AMP
vernacular_title: Opredelenie autoantitel k retseptoram tireotropnogo gormona u bol'nykh diffuznym toksicheskim zobom.