Ion transport systems in erythrocyte membrane of spontaneously hypertensive rats (SHR) as compared with normotensive rats of the Brown Norway (BN.lx) strain.
The activity of Na+, K(+)-ATPase in SHR erythrocytes treated with saponin is increased by 30-40% as compared to the Brown Norway (BN.lx) strain whereas the activity of Ca(2+)-ATPase is decreased by 20-30%. Passive permeability of SHR erythrocytes determined by 86Rb influx is increased by 20-30%. In the presence of orthovanadate erythrocytes of SHR accumulate 45Ca by 80% more than BN.lx red cells. There was no difference in Na+/H+ exchange between erythrocytes of SHR and BN.lx animals.
Orlov
S N
SN
School of Biology, Moscow State University.
Pokudin
N I
NI
Postnov YuV
Kunes
J
J
Zicha
J
J
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR; D012413:Rubidium / Q000378:metabolism; D017923:Sodium-Hydrogen Exchangers
D002352:Carrier Proteins; D017923:Sodium-Hydrogen Exchangers; D012413:Rubidium