title: Histologic evaluation of the osseous adaptation to titanium and hydroxyapatite-coated titanium implants.
abstract: The aim of this study was to obtain more information about the bone reaction to titanium and hydroxyapatite (HA)-coated titanium implants during the first 3 months after implantation. Therefore, uncoated and coated implants were inserted into the tibia of rabbits for various implantation periods. The histological results demonstrated that although there were no marked differences in bony reaction at the cortical level to the different implant materials, HA-coating appeared to induce more bone formation in the medullary cavity. It was also noted, that 3 months after insertion loss of coating thickness had occurred.
authors.affiliation: Dept. Biomaterials, School of Medicine, University of Leiden, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Jansen
authors.forename: J P
authors.initials: JP
authors.lastname: van de Waerden
authors.forename: J G
authors.initials: JG
authors.lastname: Wolke
authors.forename: K
authors.initials: K
authors.lastname: de Groot
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001858:Bone Nails; D016723:Bone Remodeling; D001863:Bone Screws; D001842:Bone and Bones / Q000166:cytology* / Q000473:pathology; D017886:Durapatite; D006652:Histological Techniques; D006882:Hydroxyapatites; D011817:Rabbits; D013997:Time Factors; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites; D017886:Durapatite; D014025:Titanium