Altered neurochemical markers in Rett's syndrome.
Rett's syndrome (RS) is a neurologic disorder associated with severe mental deficiency and neurologic manifestations of cortical and extrapyramidal origin. The present report is a preliminary postmortem brain study that compares the levels of endogenous biogenic amines and selected neurotransmitter receptors in five cases with RS and six normal controls of similar age. The level of choline acetyltransferase activity was reduced in several cortical and subcortical regions. Endogenous levels of dopamine in the superior frontal and superior temporal gyri, occipital cortex, and putamen were reduced. The changes in specific neurotransmitter markers, particularly those associated with the basal ganglia and cortex, may underlie the progressive deterioration in motor and cognitive function characteristic of this progressive disorder.
Wenk
G L
GL
Department of Psychology, Johns Hopkins University, Baltimore, MD.
Naidu
S
S
Casanova
M F
MF
Kitt
C A
CA
Moser
H
H
D000293:Adolescent; D000328:Adult; D001679:Biogenic Amines / Q000032:analysis*; D015415:Biomarkers; D001923:Brain Chemistry; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D017981:Receptors, Neurotransmitter / Q000032:analysis*; D015518:Rett Syndrome / Q000378:metabolism*
D001679:Biogenic Amines; D015415:Biomarkers; D017981:Receptors, Neurotransmitter