Differences in vascular response between primary and transplanted tumours.
The vast majority of studies on tumour vasculature are performed on transplanted tumours in rodents. However, it is known that there may be differences between primary and transplanted lesions. The purpose of this study is to test whether a specific vascular response is similar in primary tumours and in transplanted tumours derived from them. The technique used was to give an intraperitoneal injection of 5 mg kg-1 hydralazine, which is known to result in hypoxia in transplanted tumours. Changes in perfusion were indicated by changes in metabolism, monitored using 31P Magnetic Resonance Spectroscopy. The primary tumours were induced by local irradiation many months previously and only 4/11 (36%) of these responded to hydralazine. One of the non responders was subsequently transplanted into isogeneic mice to produce a tumour line which was histologically very similar to the primary. Of these 16/17 (94%) responded. The difference is statistically significant (P = 0.001). The reasons for this difference are not known. A number of possibilities are discussed and in the authors' opinion, the most likely cause is that it results from an artefact of transplantation.
Field
S B
SB
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Needham
S
S
Burney
I A
IA
Maxwell
R J
RJ
Coggle
J E
JE
Griffiths
J R
JR
D000818:Animals; D005350:Fibroma / Q000098:blood supply; D005354:Fibrosarcoma / Q000098:blood supply; D018219:Histiocytoma, Benign Fibrous / Q000098:blood supply; D006830:Hydralazine / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009381:Neoplasms, Radiation-Induced / Q000098:blood supply*; D010758:Phosphorus; D012039:Regional Blood Flow / Q000187:drug effects; D012878:Skin Neoplasms / Q000098:blood supply* / Q000209:etiology
D006830:Hydralazine; D010758:Phosphorus