title: Interaction of RuCl2 (dimethylsulphoxide)4 isomers with DNA.
abstract: A wide series of restriction enzymes with a range of specificities was used to investigate the interaction with DNA of Ru(II)-DMSO complexes with anticancer activity. While cis-RuCl2 (DMSO)4 was almost completely inactive, treatment of pBR 322 DNA with trans-RuCl2 (DMSO)4 protected G rich sequences from cutting of specific restriction endonucleases, indicating a preferential interaction with adjacent guanines.
authors.affiliation: Dip. Scienze Biomediche e Oncologia Umana, Policlinico, Bari, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Loseto
authors.forename: E
authors.initials: E
authors.lastname: Alessio
authors.forename: G
authors.initials: G
authors.lastname: Mestroni
authors.forename: G
authors.initials: G
authors.lastname: Lacidogna
authors.forename: A
authors.initials: A
authors.lastname: Nassi
authors.forename: D
authors.initials: D
authors.lastname: Giordano
authors.forename: M
authors.initials: M
authors.lastname: Coluccia
mesh_terms: D001483:Base Sequence; D004262:DNA Restriction Enzymes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004269:DNA, Bacterial / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000032:analysis*; D008969:Molecular Sequence Data; D010957:Plasmids; D015183:Restriction Mapping
chemical_list: D004269:DNA, Bacterial; D004262:DNA Restriction Enzymes; D004121:Dimethyl Sulfoxide