Central and peripheral actions of alpha-MSH in the thermoregulation of rats.
The effect of alpha-MSH on thermoregulation in rats at room temperature was examined. alpha-MSH (1 microgram ICV or 30 micrograms IP) alone did not alter temperature. However, this peptide was a potent antipyretic when administered centrally or peripherally in rats treated with pyrogen derived from Salmonella typhi.
Villar
M
M
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Perassi
N
N
Celis
M E
ME
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000502:physiology; D005334:Fever / Q000517:prevention & control; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D000521:alpha-MSH / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000521:alpha-MSH