title: [Differentiated psychopharmacotherapy of anergic conditions and the search for predictors of its effectiveness].
abstract: A nosologically nonuniform group of patients with predominant anergy in the clinical symptomatology were examined and treated. During examination, use was made of the rating scale and of the "biological" tests: the dexamethasone test, response to a single intake of psychostimulants (methylphenidate or sydnocarb) and tranquilizers (the diazepam test). The treatment was carried out by means of different methods: with antidepressants (desipramine/petytyl) and incazane, with the "actoprotector" bemityl, the psychostimulant sydnocarb, the neuroleptic pimozide as well as with combinations of the two latter ones with incazane. Analysis of the correlations between the treatment results and the data of the clinico-nosological assessment and tests made it possible to reveal the efficacy predictors in 6 out of 7 methods employed. It should be noted that for three of them the correlations with the parameters of the tests offered turned out maximal, which supports advisability of the use of the given tests for differential diagnosis and choice of the treatment for patients with anergic conditions.
authors.forename: V M
authors.initials: VM
authors.lastname: Podgrushnyĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D001247:Asthenia / Q000188:drug therapy* / Q000523:psychology; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010868:Pimozide / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D013558:Sydnones / Q000627:therapeutic use
chemical_list: D011619:Psychotropic Drugs; D013558:Sydnones; D010868:Pimozide; D003975:Diazepam; C009257:sidnocarb
vernacular_title: Differentsirovannaia psikhofarmakoterapiia anergicheskikh sostoianiĭ i poisk prediktorov ee éffektivnosti.