Is there a relationship between 5-HT1B receptors and the mechanisms of action of antidepressant drugs in the learned helplessness paradigm in rats?
The present study was undertaken to investigate, in the learned helplessness paradigm, (1) the effects of CGS 12066B, a selective 5-HT1B receptor agonist administered alone, and (2) the effects of CGS 12066B co-administered with tricyclics (clomipramine, imipramine) or 5-HT re-uptake blockers (citalopram, fluvoxamine). The results showed that (1) the selective 5-HT1B agonist failed to reverse the escape deficit, and (2) in the drug interaction studies, CGS 12066B did not modify the ability of tricyclics to reverse the escape deficit. The 5-HT1B agonist, however, did significantly reduce the ability of 5-HT re-uptake blockers to reverse the escape deficit. These results suggest that modulation of 5-HT1B sites might modify the enhancement of 5-HT neurotransmission by antidepressants, particularly 5-HT re-uptake blockers.
Martin
P
P
Département de Pharmacologie, Faculté de Médecine Pitié-Salpêtrière, Paris, France.
Puech
A J
AJ
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D004597:Electroshock; D006380:Helplessness, Learned; D008297:Male; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D011810:Quinoxalines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C052561:CGS 12066B