[Expression, amplification and rearrangement of c-myc gene in human thyroid carcinoma].
The structure and expression of c-myc oncogene was analyzed by molecular hybridization in tumor tissues from 15 patients with primary thyroid carcinoma, 3 patients with thyroid adenoma and in tissues from 5 normal and 1 adjacent non-neoplastic thyroid. We found that in 9 of the 15 cancer patients, c-myc oncogene was overexpressed (ie, at levels 3-11 times higher than in normal thyroid tissues). Rearrangement of c-myc gene was observed in 4 cancer samples, of which one showed a 150-fold amplification of c-myc gene. Overexpression, amplification of c-myc gene were frequently detected in thyroid cancer patients with more malignant and unfavourable prognosis, which suggested that overexpression, amplification and rearrangement of c-myc oncogene may be associated with unfavourable prognosis of thyroid carcinoma. It has been shown that the activated c-myc oncogene may play an important role in the initiation and progress of thyroid carcinoma.
Yang
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D000230:Adenocarcinoma / Q000235:genetics; D000236:Adenoma / Q000235:genetics; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D016259:Genes, myc / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000235:genetics*