Lack of evidence for involvement of Epstein-Barr virus in the development of the "Quilty" lesion of transplanted hearts: an in situ hybridization study.
We investigated the possible relationship of Epstein-Barr virus to the development of subendocardial lymphocytic infiltrates. In situ hybridization for Epstein-Barr virus genomic sequences was performed in 22 heart biopsy specimens with subendocardial infiltrates for 19 heart transplant patients. Epstein-Barr virus genomic sequences were not detected in the lymphocytes or myocytes in any of the heart biopsy specimens. We conclude that Epstein-Barr virus is not related to the development of subendocardial lymphocytic infiltrates.
Nakhleh
R E
RE
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455.
Copenhaver
C M
CM
Werdin
K
K
McDonald
K
K
Kubo
S H
SH
Strickler
J G
JG
D001706:Biopsy; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D016679:Genome, Viral; D016027:Heart Transplantation / Q000473:pathology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008214:Lymphocytes / Q000382:microbiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*
D015342:DNA Probes; D004279:DNA, Viral