The influence of 17-beta-estradiol 17-beta-acetate on adenylyl cyclase activity and aminoacyl-tRNA synthetase phosphatase activity in ovariectomized NMRI mice.
Adenylyl cyclase activity in the uterus of ovariectomized NMRI mice showed an increase of 87% four minutes after intraperitoneal administration of 17-beta-estradiol 17-beta-acetate in water solution, while in the liver of the same animals activity had decreased by 57%. At the same time, the activity of the 51 kDa form of the aminoacyl-tRNA synthetase phosphatase in the uterus showed an increase of 400%, while in the liver a decrease of 60% was observed. Sixty minutes after hormone injection the adenylyl cyclase activities showed no difference from controls.
Berg
B H
BH
Department of Biochemistry, University of Bergen, Norway.
D000262:Adenylyl Cyclases / Q000187:drug effects*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D010052:Ovariectomy; D010749:Phosphoprotein Phosphatases / Q000187:drug effects*; D010766:Phosphorylation; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D004958:Estradiol; C072350:estradiol 17-acetate; D000242:Cyclic AMP; C022354:phosphoaminoacyl-tRNA synthetase phosphatase; D010749:Phosphoprotein Phosphatases; D000262:Adenylyl Cyclases