title: Antiviral agents: synthesis of furylpyrimidinones and evaluation of their cytostatic and antiviral activity.
abstract: Condensation between furyllithium reagents and pyrimidinones 1, 2, 3, and 4 has been studied. The product composition is strongly dependent upon the reaction conditions and purification methodologies. Cytostatic and antiviral activities of some substrates and reaction products is reported.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università di Siena.
authors.forename: M
authors.initials: M
authors.lastname: Botta
authors.forename: F
authors.initials: F
authors.lastname: De Angelis
authors.forename: F
authors.initials: F
authors.lastname: Corelli
authors.forename: M
authors.initials: M
authors.lastname: Menichincheri
authors.forename: R
authors.initials: R
authors.lastname: Nicoletti
authors.forename: M E
authors.initials: ME
authors.lastname: Marongiu
authors.forename: A
authors.initials: A
authors.lastname: Pani
authors.forename: P
authors.initials: P
authors.lastname: La Colla
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014709:Vero Cells
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D005663:Furans; D011744:Pyrimidinones