Dual antagonists of platelet activating factor and histamine. Identification of structural requirements for dual activity of N-Acyl-4-(5,6-dihydro-11H-benzo [5,6]cyclohepta-[1,2-b]pyridin-11-ylidene)piperidines.
Piwinski
J J
JJ
Department of Chemical Research, Schering-Plough Corporation, Bloomfield, New Jersey 07003.
Wong
J K
JK
Green
M J
MJ
Ganguly
A K
AK
Billah
M M
MM
West
R E
RE
Kreutner
W
W
D000818:Animals; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008168:Lung / Q000187:drug effects / Q000502:physiology; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
D006634:Histamine H1 Antagonists; D007202:Indicators and Reagents; D010880:Piperidines; D010972:Platelet Activating Factor; D011969:Receptors, Histamine H1