Renal glomerular endothelin receptors in rats with high-output heart failure.
Plasma immunoreactive endothelin (irET) concentration and renal glomerular ET receptors were investigated in rats with chronic high-output heart failure. Plasma irET was higher (0.67 +/- 0.03 fmol/ml vs. 0.52 +/- 0.04 fmol/ml) and the density of glomerular ET receptors lower (Bmax: 420 +/- 20 fmol/mg protein vs. 510 +/- 12 fmol/mg protein) in rats with heart failure than in controls. Our results indicate that circulating ET levels are responsive to changes in cardiovascular hemodynamics and suggest a potential role for ET as a vasoactive regulatory peptide during heart failure.
Gauquelin
G
G
Laboratory of Experimental Hypertension and Vasoactive Peptides, Clinical Research Institute of Montreal, Quebec, Canada.
Thibault
G
G
Garcia
R
R
D000818:Animals; D001835:Body Weight; D016534:Cardiac Output, High / Q000378:metabolism*; D016232:Endothelins / Q000097:blood; D006333:Heart Failure / Q000378:metabolism* / Q000503:physiopathology; D006400:Hematocrit; D007678:Kidney Glomerulus / Q000737:chemistry*; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017466:Receptors, Endothelin
D016232:Endothelins; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin