LH-RH receptors in the human pancreas. Basis for antihormonal treatment in ductal carcinoma of the pancreas.
LH-RH-, estrogen-, and progesterone-receptor binding was measured in the human pancreas of patients with ductal pancreatic cancer (n = 23) and chronic pancreatitis (n = 15), and of organ donors (n = 11). Receptor analysis was determined by incubation of the homogenized tissues with estrogen, progesterone, and the LH-RH analog buserelin labeled with iodine-125. Only one biopsy (9%) from normal pancreas had an LH-RH-receptor concentration greater than 3 fmol/mg membrane protein. LH-RH binding levels greater than 3 fmol/mg were detected in 67% of patients with chronic pancreatitis and in 57% of patients with pancreatic cancer. Progesterone levels greater than 15 fmol/mg membrane protein were found in 36% of normal pancreas, in 27% of chronic pancreatitis, and in 17% of pancreatic cancer cases, respectively. The highest concentration of estrogen receptors (greater than 15 fmol/mg membrane protein) was seen in normal pancreas (73%). The increase in LH-RH-receptor concentration in chronic pancreatitis and pancreatic cancer seems to be unspecific, but might be of benefit for antiproliferative treatment in pancreatic cancer.
Friess
H
H
Department of General Surgery, University of Ulm, FRG.
Büchler
M
M
Kiesel
L
L
Krüger
M
M
Beger
H G
HG
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004967:Estrogens / Q000378:metabolism; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000737:chemistry* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000378:metabolism; D010195:Pancreatitis / Q000378:metabolism*; D011374:Progesterone / Q000378:metabolism; D011869:Radioligand Assay; D011960:Receptors, Estrogen / Q000032:analysis; D011966:Receptors, LHRH / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis
D004967:Estrogens; D011960:Receptors, Estrogen; D011966:Receptors, LHRH; D011980:Receptors, Progesterone; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone