Anti-pentylenetetrazol effect of intranigral 2-amino-7-phosphonoheptanoate attenuated by muscimol.
Bilateral injection of 2-amino-7-phosphonoheptanoate (2-APH), a selective N-methyl-D-aspartate (NMDA) receptor antagonist, into substantia nigra pars reticulata (SNpr) significantly and dose-dependently suppressed tonic pentylenetetrazol (PTZ) seizures (100 mg/kg, i.p.). The results confirm the anticonvulsant effectiveness of 2-APH and the capacity of SNpr to modulate PTZ seizure activity. The anti-PTZ effect of 2-APH was significantly attenuated by muscimol, co-infused into SNpr. This result supports the hypothesis, drawn from earlier studies, that intranigral muscimol can interfere with the anti-PTZ actions of other intranigral treatments.
Xie
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Department of Pharmacology, Medical College of Ohio, Toledo 43699.
Tietz
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Rosenberg
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D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D008297:Male; D009118:Muscimol / Q000008:administration & dosage / Q000627:therapeutic use*; D010433:Pentylenetetrazole; D014677:Pharmaceutical Vehicles; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism
D000596:Amino Acids; D000927:Anticonvulsants; D004338:Drug Combinations; D014677:Pharmaceutical Vehicles; D011963:Receptors, GABA-A; D009118:Muscimol; D015763:2-Amino-5-phosphonovalerate; C031231:2-amino-7-phosphonoheptanoic acid; D010433:Pentylenetetrazole