[Cyclosporin A: experience of the Renal Transplant Unit of the Clinical Hospital of the Medical College of the University of Sao Paulo].
The authors report their experience using cyclosporine-A (CsA) in renal transplant patients. When compared with azathioprine/prednisone, CsA contributed significantly to a better graft and patient survival, either if used associated with prednisone of with azathioprine plus prednisone. CsA was also used in substitution to azathioprine in patients with hepatopathy attributed to azathioprine toxicity. The initial results are promising. The association of CsA and azathioprine with corticosteroids withdrawal was used as an attempt to allow normal growth in children. This seems to be the best choice of treatment for children. Careful monitoring of CsA blood levels avoids, or at least, minimizes nephrotoxicity. To achieve therapeutic CsA levels, patients with liver damage need lower, while children need higher oral CsA doses. To summarise: when CsA in carefully used, it is an excellent immunosuppressive drug.
Ianhez
L E
LE
Fac. de Med., Univ. de São Paulo.
Chocair
P R
PR
Fonseca
J A
JA
Azevedo
L S
LS
de Paula
F J
FJ
David Neto
E
E
Romão Júnior
J E
JE
Galvão
M M
MM
de Castro
M C
MC
Arap
S
S
D001379:Azathioprine / Q000627:therapeutic use; D001938:Brazil; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006757:Hospital Units; D006785:Hospitals, University; D006801:Humans; D016030:Kidney Transplantation; D011241:Prednisone / Q000627:therapeutic use
D016572:Cyclosporine; D001379:Azathioprine; D011241:Prednisone
Ciclosporina A: experiência da Unidade de Transplante Renal do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.