Two t(9;22) leukemia cell lines (NALM-24 and NALM-25) with bi-phenotypic characteristics and an EBV-positive B-cell non-leukemia cell line (B262) established from a patient with acute lymphoblastic leukemia.
Based on the immunophenotypic, cytogenetic and genotypic findings, two unique leukemia cell lines, NALM-24 and NALM-25, and an EBV-transformed "normal" B-lymphoblastoid cell line (B262) from a patient with ALL were established and characterized. NALM-24 and NALM-25 are unique in that expression of both show B cell and myeloid cell features with the t(9;22) chromosome in single clonal leukemic cell populations.
Matsuo
Y
Y
Fujisaki Cell Center, Hayashibara Biochemical Laboratories, Inc.
Ariyasu
T
T
Adachi
T
T
Tsubota
T
T
Minowada
J
J
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D015139:Blotting, Southern; D002461:Cell Line, Transformed; D002472:Cell Transformation, Viral; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007621:Karyotyping; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured
D000954:Antigens, Surface; D004273:DNA, Neoplasm