title: Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I.
abstract: Previous studies reported that intracerebroventricular (ICV) infusion of insulin decreased food intake in rats and baboons. Insulin can bind to insulin-like growth factor I (IGF-I) receptors and mimic the response of IGF-I. Our objective was to determine the effects of ICV infused-insulin or IGF-I on food intake in sheep. In the present study, a 6-day ICV infusion of insulin (123 ng/kg of body weight/day) but not of IGF-I (123 ng/kg of body weight/day) decreased food intake by 40% (p less than 0.003) and body weight (p less than 0.015) compared with control sheep. In addition, sheep that received ICV insulin or IGF-I had only half the concentration of insulin in serum as compared with controls. Our results support the hypothesis that ICV insulin does not decrease food intake through IGF-I receptors. Nevertheless, apparently both insulin and IGF-I in the brain can influence the concentration of insulin in blood.
authors.affiliation: Department of Animal Science, College of Veterinary Medicine, Michigan State University, East Lansing 48823.
authors.forename: L A
authors.initials: LA
authors.lastname: Foster
authors.forename: N K
authors.initials: NK
authors.lastname: Ames
authors.forename: R S
authors.initials: RS
authors.lastname: Emery
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology*; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008297:Male; D011972:Receptor, Insulin / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology*; D017451:Receptors, Somatomedin; D012756:Sheep
chemical_list: D007328:Insulin; D011956:Receptors, Cell Surface; D017451:Receptors, Somatomedin; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin