title: Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes.
abstract: The human genes encoding the alpha and beta forms of the retinoic acid receptor are known to be located on chromosomes 17 (band q21.1:RARA) and 3 (band p24:RARB). By in situ hybridization, we have now localized the gene for retinoic acid receptor gamma, RARG, on chromosome 12, band q13. We also mapped the three retinoic acid receptor genes in the mouse, by in situ hybridization, on chromosomes 11, band D (Rar-a); 14, band A (Rar-b); and 15, band F (Rar-g), respectively, and in the rat, using a panel of somatic cell hybrids that segregate rat chromosomes, on chromosomes 10 (RARA), 15 (RARB), and 7 (RARG), respectively. These assignments reveal a retention of tight linkage between RAR and HOX gene clusters. They also establish or confirm and extend the following homologies: (i) between human chromosome 17, mouse chromosome 11, and rat chromosome 10 (RARA); (ii) between human chromosome 3, mouse chromosome 14, and rat chromosome 15 (RARB); and (iii) between human chromosome 12, mouse chromosome 15, and rat chromosome 7 (RARG).
authors.affiliation: INSERM U 242, Hôpital d'Enfants de la Timone, Centre de Génétique Médicale, Marseille, France.
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: M
authors.initials: M
authors.lastname: Rivière
authors.forename: A
authors.initials: A
authors.lastname: Krust
authors.forename: S
authors.initials: S
authors.lastname: Ingvarsson
authors.forename: B
authors.initials: B
authors.lastname: Vennström
authors.forename: M Q
authors.initials: MQ
authors.lastname: Islam
authors.forename: G
authors.initials: G
authors.lastname: Levan
authors.forename: P
authors.initials: P
authors.lastname: Kautner
authors.forename: A
authors.initials: A
authors.lastname: Zelent
authors.forename: P
authors.initials: P
authors.lastname: Chambon
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002352:Carrier Proteins / Q000235:genetics*; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology; D008297:Male; D008677:Metaphase; D051381:Rats; D018168:Receptors, Retinoic Acid; D014212:Tretinoin / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D004247:DNA