Is there a SV40 middle T antigen?
It is hypothesized that Simian Virus 40 (SV40) produces a middle T antigen with a mRNA almost the same size as the small t antigen mRNA and a protein similar in size to that of large T antigen. Both middle T mRNA and protein, therefore, would not be readily discernable. Disruption or removal of the small t antigen translation stop codon by post-transcriptional RNA processing could provide a mechanism to achieve the above. A key role for the small t intron in this process is suggested.
Goldberg
Y P
YP
Department of Medical Biochemistry, University of Cape Town Medical School, South Africa.
Parker
M I
MI
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics* / Q000302:isolation & purification; D002472:Cell Transformation, Viral; D003062:Codon; D005814:Genes, Viral; D007438:Introns; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D013539:Simian virus 40 / Q000235:genetics* / Q000502:physiology; D013728:Terminator Regions, Genetic; D015678:Viral Structural Proteins / Q000235:genetics; D016335:Zinc Fingers / Q000235:genetics
D000952:Antigens, Polyomavirus Transforming; D003062:Codon; D012333:RNA, Messenger; D012367:RNA, Viral; D015678:Viral Structural Proteins