[Risk of CMV infection and illness after kidney transplantation].
Between 1980 and 1986 465 cadaveric kidney transplants were performed at the Kidney Transplant Centre Berlin-Friedrichshain. The post-transplant risk to acquire a cytomegalovirus (CMV) infection depended on the preoperative CMV antibody status of donor and recipient, on the nettoimmunosuppression and on the recipient's age. The highest infection rate and the most serious courses showed seronegative recipients from seropositive donors. The typical time interval of clinical manifestation included the postoperative months 1-3. A significant dependence of the frequency of infection on different immunosuppressive protocols could not be proven. But there was a significant coincidence between CMV infection and rejection crises. In spite of the raised frequency of rejection crises an influence of the CMV infection on the 1-year-graft and patient survival rates could not be demonstrated. Both an early diagnosis and an adequate therapy are of particular importance.
Kaden
J
J
Urologische Klinik, Bereiches Medizin (Charité), Humboldt-Universität zu Berlin, Bundesrepublik Deutschland.
Zenker
S
S
Eichler
C
C
Groth
J
J
May
G
G
Strobelt
V
V
Oesterwitz
H
H
Scholz
D
D
Lippert
J
J
Adamczyk
G
G
D000367:Age Factors; D000914:Antibodies, Viral / Q000032:analysis; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D014019:Tissue Donors
D000914:Antibodies, Viral
Das CMV-Infektions- und Erkrankungsrisiko nach Nierentransplantation.