The possible influence of testosterone on calcium ion transport (investigated) in guinea pig uterus.
The influence of testosterone on voltage-dependent calcium channels was observed indirectly in Ca(2+)-free depolarizing K+ solution (DKS). In this solution cumulative dose response curves to CaCl2 by increasing the Ca2+ concentration in logarithmic increments (10(-5)-10(-3) mol.1(-1] were obtained. The maximal response to CaCl2 and pD2 value were evaluated in these experiments. Decrease of guinea pig uterus contractility to CaCl2 after testosterone (T) administration was found. The pD2 value was unchanged. The possible influence of testosterone on calcium ion release from intracellular storage was investigated in Ca(2+)-free Tyrode's solution (TS). The reactivity of uterus to oxytocin (OT) at a dose of 2.10(-4) mol.1(-1) was decreased after testosterone administration. According to these results an important role of testosterone on calcium ion transport in myometrial cells could be suggested.
Sochorová
R
R
Department of Pathological Physiology, School of Medicine, Comenius University, Bratislava, Czechoslovakia.
Mosnárová
A
A
Huzuláková
I
I
D000818:Animals; D015220:Calcium Channels; D000252:Calcium-Transporting ATPases; D005260:Female; D006168:Guinea Pigs; D013739:Testosterone / Q000493:pharmacokinetics*; D014599:Uterus / Q000378:metabolism*
D015220:Calcium Channels; D013739:Testosterone; D000252:Calcium-Transporting ATPases