[Erythrocyte membranes in patients with congenital cyanotic heart disease before and after obsidan therapy].
Tissue oxygen tension, peroxidation of lipids (malonic dialdehyde levels, superoxide dismutase activity), fatty acid, spectrum and phospholipid composition in the red blood cells, Na+, K(+)-ATPase were studied in 11 healthy children and 21 with cyanotic heart disease. The beta-adrenoblocker obsidan was used in the multimodality treatment of 10 patients. Unlike healthy children, the patients had decreased tissue oxygen tension, intensified lipid peroxidation, an altered lipid profile in the red blood cell membranes, their abnormal permeability, diminished intracellular ATP depot. The conventional tools of intensive care (oxygenation, cardiotropic drugs, goal-oriented fluid therapy) are low beneficial. There is evidence for the supplementation of obsidan, a beta-adrenoblocker, to a therapeutical complex for this group of patients. Clinical and metabolic evidence for the positive action of the drug on lipid peroxidation, lipid spectrum in the red blood cell membranes, their permeability and biological energy reactions.
Minkov
I P
IP
D002675:Child, Preschool; D003490:Cyanosis; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D006330:Heart Defects, Congenital / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D008563:Membrane Lipids / Q000097:blood; D010743:Phospholipids / Q000097:blood; D011433:Propranolol / Q000627:therapeutic use*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids; D011433:Propranolol; D000254:Sodium-Potassium-Exchanging ATPase
Sostoianie éritrotsitarnykh membran u bol'nykh vrozhdennymi porokami serdtsa sinego tipa do i posle lechenia obzidanom.