[Preliminary clinical study of the use of itraconazole in the treatment of vulvovaginal candidiasis].
Thirty women (28 of childbearing age and 2 in the menopause), affected by acute Candida albicans vulvovaginitis were treated orally with a new antimycotic triazole derivative, itraconazole. Twenty patients were administered with 200 mg/die of itraconazole for three days. In tests carried out 7 and 30 days after the end of therapy the following results were observed. Negative cultures in 95% of patients and in 75% of patients; absence of leukorrhea in 60% of patients and in 65% of patients; disappearance of pruritus in 95% of patients and in 80% of patients. Ten patients were administered with an acute dose of itraconazole (400 mg). In the same tests, carried out 7 and 30 days after the end of therapy reported above the results were as follow. Negative culture in 80% and 60% of patients; absence of leukorrhea in 50% and 60% of patients; absence of pruritus in 70% and 50% of patients. In the first group of patients one case of slight nausea was reported whilst in the second group there were two cases of nausea, one of gastralgia and one of urticaria. No systemic side-effect was seen.
Baraggino
E
E
Clinica Ostetrica e Ginecologica, Università di Trieste.
Orsetti
G
G
Ribaric
G
G
Wiesenfeld
V
V
Pecorari
D
D
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D017964:Itraconazole; D007654:Ketoconazole / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008875:Middle Aged
D000935:Antifungal Agents; D017964:Itraconazole; D007654:Ketoconazole
Studio clinico preliminare sull'impiego dell'itraconazolo nel trattamento della vulvovaginite da candida.