Impaired intrathyroidal iodine organification and iodine-induced hypothyroidism in euthyroid women with a previous episode of postpartum thyroiditis.
Postpartum thyroiditis (PPT) is common and occurs in 1.7 to 16.7% of pregnant women, depending upon the study population. Most of these women develop transient hypothyroidism and thyroid function usually returns to normal. We have studied 11 euthyroid women with a previous history of PPT to determine the incidence of subtle defects in thyroid function measured by iodide-perchlorate (I-ClO4) discharge tests and TRH tests and to determine whether these women would develop iodide-induced hypothyroidism. Seven (64%) had positive I-ClO4 discharge tests and 5 (46%) had an abnormally high TSH response to TRH. Thyroid antimicrosomal and antithyroid peroxidase were positive in 8 women (73%) with a previous episode of PPT. The administration of pharmacological amounts of iodide (10 drops of saturated solution of potassium iodide daily) for 90 days to these 11 women resulted in elevated basal and TRH stimulated serum TSH concentrations in 8 (72.7%) compared to TSH values during iodide administration to women who had never been pregnant. Antimicrosomal and antithyroid peroxidase concentrations did not change during iodide administration. These findings strongly suggest that euthyroid women with a previous episode of PPT have permanent subtle defects in thyroid hormone synthesis and are inordinately prone to develop iodide-induced hypothyroidism, similar to findings previously reported in euthyroid subjects with Hashimoto's thyroiditis, with a previous episode of painful subacute thyroiditis, or previously treated with radioactive iodine or surgery for Graves' disease.
Roti
E
E
Centro per lo Studio, Prevenzione, Diagnosi e Cura delle Tireopatie, Universita di Parma, Italy.
Minelli
R
R
Gardini
E
E
Bianconi
L
L
Neri
T
T
Gavaruzzi
G
G
Ugolotti
G
G
Salvo
D
D
Braverman
L E
LE
D000328:Adult; D000704:Analysis of Variance; D001323:Autoantibodies / Q000032:analysis; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007453:Iodide Peroxidase / Q000276:immunology; D007457:Iodine Radioisotopes; D008861:Microsomes / Q000276:immunology; D010472:Perchlorates; D011188:Potassium; D017680:Potassium Compounds; D011193:Potassium Iodide / Q000627:therapeutic use*; D011644:Puerperal Disorders / Q000503:physiopathology*; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000276:immunology; D013966:Thyroiditis / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D001323:Autoantibodies; D007457:Iodine Radioisotopes; D010472:Perchlorates; D017680:Potassium Compounds; D014284:Triiodothyronine; D011193:Potassium Iodide; C009006:potassium perchlorate; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D007453:Iodide Peroxidase; D013974:Thyroxine; D011188:Potassium