title: Assessment of ventricular function with first-pass radionuclide angiography using technetium 99m hexakis-2-methoxyisobutylisonitrile: a European multicentre study.
abstract: In the context of a multicentre study on the use of technetium 99m hexakis-2-methoxyisobutylisonitrile (99mTc-Sestamibi), we evaluated the accuracy of the ventricular function assessed at rest by means of first-pass radionuclide angiocardiography acquired during the injection of the tracer for myocardial perfusion scintigraphy. The results were compared with first-pass studies performed using reference tracers sodium pertechnetate Tc 99m or technetium 99m diethylene triamine penta-acetic acid or with gated radionuclide angiocardiography. A total of 66 patients of the 105 enrolled in the study could be evaluated. The comparison of the first-pass studies was possible in 33 subjects with regard to the left ventricular ejection fraction, yielding r = 0.909 (P less than 10(-6)), and in 22 cases with regard to the right ventricular ejection fraction, yielding r = 0.712 (P less than 0.001). The comparison between the first-pass study using 99mTc-Sestamibi and the equilibrium gated radionuclide angiocardiography was possible for the left ventricular ejection fraction in 26 cases, with r = 0.937 (P less than 10(-6)), and for the right ventricular ejection fraction in 15 subjects, with r = 0.783 (P less than 0.001). In conclusion, the assessment of ventricular function performed by acquiring a first-pass radionuclide angiocardiograph during the injection of 99mTc-Sestamibi for perfusion myocardial scintigraphy can be considered reliable and accurate, when compared with the usually employed techniques. This result confirms the feasibility of a combined evaluation of perfusion and function at rest and during stress testing, which represents one of the most interesting advantages offered by the use of 99mTc-Sestamibi.
authors.affiliation: Dipartimento di Fisiopathologia Clinica, Università di Firenze, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bisi
authors.forename: R
authors.initials: R
authors.lastname: Sciagrà
authors.forename: U
authors.initials: U
authors.lastname: Büll
authors.forename: K E
authors.initials: KE
authors.lastname: Britton
authors.forename: C
authors.initials: C
authors.lastname: Eilles
authors.forename: D
authors.initials: D
authors.lastname: Eissner
authors.forename: K
authors.initials: K
authors.lastname: Hahn
authors.forename: H
authors.initials: H
authors.lastname: Höffken
authors.forename: K
authors.initials: K
authors.lastname: Joseph
authors.forename: J H
authors.initials: JH
authors.lastname: McKillop
mesh_terms: D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009570:Nitriles; D015609:Organotechnetium Compounds; D013670:Sodium Pertechnetate Tc 99m; D016284:Technetium Tc 99m Pentetate; D017256:Technetium Tc 99m Sestamibi; D016276:Ventricular Function / Q000502:physiology*; D015646:Ventriculography, First-Pass
chemical_list: D009570:Nitriles; D015609:Organotechnetium Compounds; D017256:Technetium Tc 99m Sestamibi; D013670:Sodium Pertechnetate Tc 99m; D016284:Technetium Tc 99m Pentetate