[The effect of parathormone on the reactivity of the renal blood flow to noradrenaline in normotensive and spontaneously hypertensive rats].
The effect of parathyroid hormone on the renal cortex and medulla hemodynamics and on systemic circulation was studied after various doses of i.v. norepinephrine in normotensive and spontaneously hypertensive rats. The experiments were performed in anesthetized and intact rats, and 12-14 hrs after parathyroid hormone i.m. injection. The latter caused similarly directed changes in the renal hemodynamics in normotensive and spontaneously hypertensive rat: the decrease of the renal cortex and the increase of the renal medulla blood flows. Parathyroid-induced response to norepinephrine in the renal cortex hemodynamics was similar in both types of rats reducing the effect. The shifts of the renal medulla response to norepinephrine were opposite in normotensive (increase) and spontaneously hypertensive rats (decrease). Parathyroid hormone increased the vascular resistance, decreased the cardiac output and reduced vascular and pressor responses to norepinephrine in normotensive rats. The parathyroid hormone dramatically decreased vascular resistance, slightly increased the cardiac output and the vascular and pressor responses to norepinephrine in spontaneously hypertensive rats.
Brin
V B
VB
Tatrov
A S
AS
Iripkhanov
B B
BB
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004347:Drug Interactions; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D012079:Renal Circulation / Q000187:drug effects* / Q000502:physiology
D010281:Parathyroid Hormone; D009638:Norepinephrine
Vliianie paratgormona na reaktivnost' pochechnogo krovotoka k noradrenalinu u normotenzivnykh i spontanno-gipertenzivnykh krys.