title: Effect of acutely-induced lactic acidemia on fetal breathing movements, heart rate, blood pressure, ACTH and cortisol in sheep.
abstract: Experiments were conducted in 8 chronically-catheterized fetal sheep at 125-135 days gestation in order to determine the effect of exogenously administered lactic acid to the fetus on fetal heart rate, blood pressure, breathing movements (FBM), electrocortical activity (ECOG), plasma immunoreactive (IR-ACTH) and cortisol concentrations. When fetal arterial pH decreased from 7.37 +/- 0.01 during the control period to 7.20 +/- 0.01, there was an initial bradycardia followed by tachycardia but no change in blood pressure. The amplitude of FBM increased 2-fold initially in association with an increase in PCO2 from 47.9 +/- 2.1 mmHg to 58.8 +/- 3.6 mmHg at 5 min into the lactate infusion. There was no change in the incidence of FBM or low-voltage ECOG and there was no change in the plasma concentrations of IR-ACTH and cortisol with the infusion of lactate. We conclude that the major effects of acutely elevating circulatory lactate concentrations in fetal sheep are to increase the amplitude of FBM and to cause an initial bradycardia followed by a tachycardia.
authors.affiliation: Department of Obstetrics/Gynaecology, University of Western Ontario, London, Canada.
authors.forename: A D
authors.initials: AD
authors.lastname: Bocking
authors.forename: J R
authors.initials: JR
authors.lastname: Challis
authors.forename: S E
authors.initials: SE
authors.lastname: White
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005324:Fetal Movement / Q000187:drug effects; D005333:Fetus / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood* / Q000494:pharmacology; D019344:Lactic Acid; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D015656:Respiratory Mechanics / Q000187:drug effects; D012756:Sheep
chemical_list: D001786:Blood Glucose; D007773:Lactates; D019344:Lactic Acid; D000324:Adrenocorticotropic Hormone; D010100:Oxygen; D006854:Hydrocortisone