Effect of thymopentin on peripheral blood T-lymphocytes subsets and on the clinical course of the disease in patients affected by multiple sclerosis.
The effect on peripheral T-lymphocytes of Thymopentin (TP-5), asynthetic pentapeptide reproducing the biological activity of Thymopoietin, is known in Herpes Simplex infections and in Rheumatoid Arthritis. The aim of this study was to observe the effect of TP-5 on the OKT4 and OKT8 lymphocytes in Multiple Sclerosis. The AA. have studied this effect in two patients affected by definite MS, whose lymphocytes subpopulation, observed for 33 and 13.5 months respectively, showed a constant OKT4/OKT8 ratio greater than 2.5 in peripheral blood and whose clinical course was chronically progressive. TP-5 was administered during a period of one month. A decrease of the OKT4/OKT8 ratio in both patients (significant in one, p less than 0.01) due to the increase of OKT8 was observed. Also the clinical symptomatology improved in one patient.
Cognazzo
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Divisione di Neurologia, Ospedale S.S. Annunziata, Savigliano CN.
Seliak
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Fruttero
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D000595:Amino Acid Sequence; D016516:CD4-CD8 Ratio / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D006152:Cyclic GMP / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D016305:Thymopentin / Q000494:pharmacology / Q000627:therapeutic use*
D007155:Immunologic Factors; D006152:Cyclic GMP; D016305:Thymopentin