title: Fluconazole resistance of Candida krusei.
abstract: We present a case of young male treated for a recurrence of Acute Non Lymphoid Leukemia who presented a colonization by C. krusei during prophylaxis with Fluconazole. The fever episode, which he developed while neutropenic, was resolved with the addition of Amphotericin B after the failure of empiric antibiotic therapy. No isolation was performed in blood cultures. A second cycle of antiblastic chemotherapy was needed because of the resistance shown to the first. Despite the prophylaxis with Fluconazole a stream of C. krusei grew in all the blood cultures collected while febrile. Amphotericin B administered did not control the fungemia. We discuss the resistance of C. krusei to Fluconazole.
authors.affiliation: Laboratory of Microbiology, Torrette Hospital, Ancona, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Manso
authors.forename: M
authors.initials: M
authors.lastname: Montillo
authors.forename: G
authors.initials: G
authors.lastname: Discepoli
authors.forename: P
authors.initials: P
authors.lastname: Leoni
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002175:Candida / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D003561:Cytarabine / Q000008:administration & dosage; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D017809:Fatal Outcome; D015725:Fluconazole / Q000494:pharmacology* / Q000627:therapeutic use; D005437:Flucytosine / Q000627:therapeutic use; D016469:Fungemia / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage
chemical_list: D003561:Cytarabine; D000666:Amphotericin B; D015725:Fluconazole; D008942:Mitoxantrone; D005437:Flucytosine