[Specific skin infiltration in Hodgkin's disease].
A 60 year old man consults the dermatologist because of a bean sized centrally ulcerated painless tumor in the skin of his left axilla. The axillary lymph nodes proximal to the skin tumor are firm and enlarged. The skin biopsy reveals a dense mixed infiltrate composed of lymphocytes, histiocytes, plasma cells and granulocytes and there are multiple neoplastic mononuclear and some multinuclear giant cells, resembling Hodgkin- and Reed-Sternberg-cells. Thus the diagnosis of Hodgkin's disease was considered on the grounds of the skin biopsy. Immunohistologically the atypical giant cells express the CD-30 (Ki-1)-antigen. Histology of the subsequently excised lymph nodes resembled the changes in the skin and showed classical Hodgkin's disease of mixed cellularity.
Winzer
M
M
Klinik für Dermatologie und Venerologie, Medizinischen Universität Lübeck.
Müller
W
W
Arnholdt
H
H
D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D017730:Ki-1 Antigen; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016539:Reed-Sternberg Cells / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D017730:Ki-1 Antigen
Spezifische Hautinfiltrate bei Morbus Hodgkin.