[Experimental cytokinetic study of gastric mucosa in stress ulcer].
Stress ulcer was studied from the view point of cytokinetics by applying 3H-TdR double pulse labelling technique. In combination with clinical practice, the effects of three common preventive drugs Sucralfate (SCR), 25% glucose and Danshen compound were investigated. The results indicated that when stress ulcer developed, the Ts and Tc stage of gastric mucosa in the rat was much prolonged (P less than 0.01), an apparent lowering of 3H-TdR labelling index appeared (P less than 0.01), and significant impact of cytokinetic changes of mucosal cell was only seen in the region of the gastric body but not at the antral portion. SCR, 25% glucose and compound Danshen displayed a considerable protective action against ulceration and this could facilitate the recovery of Ts, Tc stage to normal range (P less than 0.01).
Gu
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D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002453:Cell Cycle; D004247:DNA / Q000096:biosynthesis; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005753:Gastric Mucosa / Q000473:pathology*; D008297:Male; D010618:Phenanthrolines / Q000627:therapeutic use; D010936:Plant Extracts; D051381:Rats; D027561:Salvia miltiorrhiza; D013276:Stomach Ulcer / Q000473:pathology* / Q000517:prevention & control; D013312:Stress, Physiological / Q000150:complications*; D013392:Sucralfate / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; D010936:Plant Extracts; C028972:dan-shen root extract; D013392:Sucralfate; D004247:DNA