title: Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and molecular study.
abstract: The normal counterparts of the B cells found in hairy cell leukemia (HCL) are not known. We report here a detailed morphological, cytochemical, immunological and molecular analysis of a patient with B-cell chronic lymphocytic leukemia (B-CLL) who later in the course of his disease developed hairy cell leukemia. We speculate that hairy cell transformation of B-CLL might be related to an in vivo protein kinase C mediated cellular activation of B-CLL cells.
authors.affiliation: Laboratoire de Cytologie et Cytogénétique, CRTS, Purpan, Toulouse, France.
authors.forename: E
authors.initials: E
authors.lastname: Duchayne
authors.forename: G
authors.initials: G
authors.lastname: Delsol
authors.forename: E
authors.initials: E
authors.lastname: Kuhlein
authors.forename: B
authors.initials: B
authors.lastname: Klein
authors.forename: X G
authors.initials: XG
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Attal
authors.forename: G
authors.initials: G
authors.lastname: Cassard
authors.forename: G
authors.initials: G
authors.lastname: Laurent
mesh_terms: D015139:Blotting, Southern; D002872:Chromosome Deletion; D002883:Chromosomes, Human, Pair 14; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D007943:Leukemia, Hairy Cell / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D007143:Immunoglobulin Heavy Chains