[Effects of calcium antagonists on functional properties of monocytes in patients with ischemic heart disease].
Monocytic production of peripheral blood thromboxane B2 and leukotriene B4, levels of cAMP and total lipids in these cells were examined in 58 patients with stable angina induced by exercise and 32 healthy donors. There was a hyperproduction of thromboxane B2 and leukotriene B4 by monocytes in the patients, a decrease in cAMP levels, and lipid accumulation in these cells in effort angina. The calcium antagonists verapamil and nifedipine abolished the above impairments. The author suggests that calcium antagonists should be regarded as a new class of antiathero-sclerotic agents that have effects predominantly on the cellular link of atherogenesis.
Glushko
L V
LV
D000787:Angina Pectoris / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood / Q000188:drug therapy*; D000242:Cyclic AMP / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D007975:Leukotriene B4 / Q000097:blood; D008055:Lipids / Q000097:blood; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology / Q000627:therapeutic use; D013929:Thromboxane B2 / Q000097:blood; D014700:Verapamil / Q000494:pharmacology / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D008055:Lipids; D007975:Leukotriene B4; D013929:Thromboxane B2; D014700:Verapamil; D000242:Cyclic AMP; D009543:Nifedipine
Vliianie antagonistov kal'tsiia na funktsional'nye svoĭstva monotsitov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.