Effect of beta agonists on protein turnover in adipose tissue.
Chronic administration (21 days) of the beta agonist cimaterol to rats decreased epididymal fat by 27%, and inhibited in vitro rates of protein synthesis by 34% and net protein breakdown by 71% in adipose tissue. Likewise, incubation of rat adipose tissue with cimaterol and isoproterenol stimulated lipolysis, and inhibited protein synthesis and degradation. Thus, in addition to affecting muscle mass and lipid metabolism, beta agonists appear to slow rates of protein turnover in adipose tissue.
Rogers
K L
KL
Department of Animal Sciences, Rutgers University, New Brunswick, New Jersey 08903.
Fagan
J M
JM
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D000284:Administration, Oral; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D046508:Culture Techniques; D004822:Epididymis / Q000187:drug effects / Q000378:metabolism; D004983:Ethanolamines / Q000008:administration & dosage / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D011506:Proteins; C047411:cimaterol