Subpopulations of GABA-mediated synaptic potentials in slices of rat dorsal striatum are differentially modulated by presynaptic GABAB receptors.
gamma-Aminobutyric acid (GABA)-mediated synaptic potentials in rat dorsal striatum in vitro were reduced in amplitude by the GABAB receptor agonists baclofen and 3-aminopropyl-(methyl)-phosphinic acid (SK&F 97541), without any detectable postsynaptic effect. Synaptic potentials in 40% of neurones were distinctly multiphasic, the components of which exhibited a differential sensitivity to GABAB agonists. One population of GABA-releasing neurones within the striatum had presynaptic GABAB autoreceptors, whereas others were not directly affected by GABAB agonists.
Seabrook
G R
GR
SmithKline Beecham Pharmaceuticals, Welwyn, Hertfordshire, U.K.
Howson
W
W
Lacey
M G
MG
D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002421:Caudate Nucleus / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000502:physiology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D011699:Putamen / Q000502:physiology*; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D013570:Synaptic Membranes / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D009943:Organophosphorus Compounds; D011963:Receptors, GABA-A; C068457:3-aminopropyl(methyl)phosphinic acid; D005680:gamma-Aminobutyric Acid; D001418:Baclofen