[Protection from foot-and-mouth disease virus in naturally-susceptible animals by a linear polymer of a synthetic peptide].
Linear polymer of a peptide corresponding to the fragment 142-155 of the foot-and-mouth disease virus A22(550) protein (VP1) was synthesized. Whereas the monomeric peptide was only slightly immunogenic, the polymer induced virus-neutralizing antibodies in rabbits and protected 100% guinea pigs. Sheep vaccinated once and cattle vaccinated twice were stable against infection with the homologous virulent foot-and-mouth disease virus.
Pavlov
A V
AV
Rybakov
S S
SS
Ivaniushchenkov
V N
VN
Chepurkin
A V
AV
Petrov
V N
VN
Driagalin
N N
NN
Burdov
A N
AN
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D005537:Aphthovirus / Q000276:immunology; D002850:Chromatography, Gel; D004198:Disease Susceptibility; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000138:chemical synthesis; D011817:Rabbits; D012756:Sheep; D014614:Vaccines, Synthetic / Q000008:administration & dosage*
D000914:Antibodies, Viral; D010446:Peptide Fragments; C073192:VP1-(142-155)n peptide; D014614:Vaccines, Synthetic
Zashchita ot iashchura estestvenno-vospriimchivykh zhivotnykh lineĭnym polimerom sinteticheskogo peptida.