Mitochondrial gene sequences show fungal homology for Pneumocystis carinii.
A 6.8 kilobase fragment of mitochondrial DNA from Pneumocystis carinii encodes for apocytochrome b, NADH dehydrogenase subunits 1, 2, 3, and 6, cytochrome oxidase subunit II, and the small subunit of ribosomal RNA. Comparative sequence analysis with a series of organisms representative of the fungal and protozoan groups shows that P. carinii has, consistently, an average similarity of 60% with the fungi but only 20% with the protozoa. The data indicate homology with the fungi for this opportunistic pathogen.
Pixley
F J
FJ
Department of Paediatrics, John Radcliffe Hospital, Oxford, UK.
Wakefield
A E
AE
Banerji
S
S
Hopkin
J M
JM
D000595:Amino Acid Sequence; D000818:Animals; D001059:Apoproteins / Q000737:chemistry / Q000235:genetics; D003001:Cloning, Molecular; D003573:Cytochrome b Group / Q000737:chemistry / Q000235:genetics; D045303:Cytochromes b; D004271:DNA, Fungal / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000737:chemistry / Q000235:genetics; D056890:Eukaryota / Q000235:genetics; D005658:Fungi / Q000235:genetics; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000737:chemistry / Q000235:genetics; D009690:Nucleic Acid Conformation; D011010:Pneumocystis / Q000145:classification / Q000235:genetics*; D012335:RNA, Ribosomal / Q000235:genetics; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid
D001059:Apoproteins; D003573:Cytochrome b Group; D004271:DNA, Fungal; D004272:DNA, Mitochondrial; D012335:RNA, Ribosomal; D045303:Cytochromes b; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV