[The cardiovascular effects of endothelin in waking rats with normal and artificially increased atriopeptide levels of the blood].
The systemic and regional hemodynamic effects of endothelin: a new vasoconstrictor peptide, were studied in alert WKY rats. The radioactive microsphere technique was used to measure cardiac output, total peripheral resistance and regional blood flow before and 10 min after bolus injection of endothelin into the left ventricle. Endothelin produced a transient hypotension followed by a long-lasting increase in blood pressure and in systemic resistance and a decrease in cardiac output. Endothelin induced a decrease in blood flow in all vascular beds to variable extent (the maximal changes were recorded in kidneys and adrenals), only the coronary blood flow being increased. In the rats receiving constant atriopeptine II infusion, the hypotensive phase of endothelin effects was augmented whereas the hypertensive phase was reduced. Atriopeptine II infusion also diminished the regional blood flow responses to endothelin in the kidneys, the adrenals and the heart.
Martynova
E P
EP
Murashev
A N
AN
Davydova
S A
SA
Medvedev
O S
OS
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000494:pharmacology; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D016232:Endothelins / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D008297:Male; D008863:Microspheres; D010446:Peptide Fragments; D011865:Radioisotope Dilution Technique; D051381:Rats; D011921:Rats, Inbred WKY; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
D016232:Endothelins; D010446:Peptide Fragments; D009320:Atrial Natriuretic Factor; C062524:atrial natriuretic factor prohormone (103-125)
Serdechno-sosudistye éffekty éndotelina u bodrstvuiushchikh krys s normal'nym i iskusstvenno uvelichennym urovnem atriopeptida v krovi.