Aggression, hyperactivity and platelet imipramine binding.
We measured platelet 3H-imipramine binding parameters in 16 subjects affected by different types of mental deficiency, all characterized by hyperactive and/or aggressive behaviour, and in 16 healthy controls. The patients had a lower maximum binding capacity than the controls, with no difference in Kd, irrespectively of the type of mental disorder. These findings suggest a link between 5-HT disturbances, reflected by reduced imipramine binding sites, and behavioural dyscontrol, expressed as hyperactivity and aggression.
Marazziti
D
D
Institute of Psychiatry Clinic, University of Pisa, Italy.
Conti
L
L
D000328:Adult; D000374:Aggression / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology; D002352:Carrier Proteins; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008607:Intellectual Disability / Q000503:physiopathology*; D008297:Male; D019965:Neurocognitive Disorders / Q000503:physiopathology; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D014754:Violence
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine