title: [A phase II study of SM-5887 for advanced gastric cancer].
abstract: A phase II clinical trial of SM-5887, a new totally synthesized anthracycline derivative, was carried out in 13 patients with inoperable or recurrent gastric cancer. No patient had been given anthracycline previously. SM-5887 was administered by I.V. bolus with a dose of 100 mg/m2 every three weeks. Twelve of 13 cases were eligible and evaluable for the response. Of the 12 evaluated cases, 6 showed no change (NC), including one minor response (MR). The remaining 6 cases showed progressive disease (PD). Adverse effects were relatively mild in most cases and included anemia, leukocytopenia, thrombocytopenia, nausea/vomiting, phlebitis, hair loss and fever. Among them, leukocytopenia was observed most frequently.
authors.affiliation: First Dep. of Internal Medicine, Hirosaki University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Tsushima
authors.forename: Y
authors.initials: Y
authors.lastname: Sakata
authors.forename: A
authors.initials: A
authors.lastname: Munakata
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Chiba
authors.forename: H
authors.initials: H
authors.lastname: Nara
authors.forename: S
authors.initials: S
authors.lastname: Kawazu
authors.forename: M
authors.initials: M
authors.lastname: Matsukawa
authors.forename: T
authors.initials: T
authors.lastname: Ohmi
authors.forename: T
authors.initials: T
authors.lastname: Aizawa
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D002288:Adenocarcinoma, Mucinous / Q000188:drug therapy; D000231:Adenocarcinoma, Papillary / Q000188:drug therapy; D000328:Adult; D000368:Aged; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy*
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; C055866:amrubicin