cAMP signal transduction pathways regulating development of Dictyostelium discoideum.
Dictyostelium discoideum development is regulated through receptor/G protein signal transduction using cAMP as a primary extracellular signal. Signaling pathways will be discussed as well as the regulation and function of individual cAMP receptors and G alpha subunits. Finally potential downstream targets including protein kinases and nuclear events will be explored.
Kimmel
A R
AR
Laboratory of Cellular and Developmental Biology, NIDDK/NIH, Bethesda, Maryland 20892.
Firtel
R A
RA
D000262:Adenylyl Cyclases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D002465:Cell Movement / Q000235:genetics; D000242:Cyclic AMP / Q000502:physiology*; D004023:Dictyostelium / Q000235:genetics / Q000254:growth & development*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D008954:Models, Biological; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D011953:Receptors, Cyclic AMP / Q000235:genetics; D015290:Second Messenger Systems
D005656:Fungal Proteins; D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP; D011494:Protein Kinases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases