[The modelling of a persistent parainfluenza infection].
A model of parainfluenza persistent infection was developed in guinea pigs, based on the use of the suckling-adapted virus and an immunosuppressor cyclophosphan. The latter increased the titre of virus and its antigen and duration of their detection in the organs, but the dynamics of these findings was different, and also delayed the time of appearance and slightly prolonged the period of detection of antibody.
Ukbaeva
T D
TD
Karal'nik
B V
BV
Ismagulov
A T
AT
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000032:analysis; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008168:Lung / Q000382:microbiology; D010224:Parainfluenza Virus 3, Human / Q000276:immunology; D018184:Paramyxoviridae Infections / Q000276:immunology / Q000382:microbiology*; D012692:Serial Passage; D013997:Time Factors
D000914:Antibodies, Viral; D000956:Antigens, Viral; D003520:Cyclophosphamide
Modelirovanie persistentnoĭ paragrippoznoĭ infektsii.