Mucosal immune dysfunction associated with alcoholic IgA nephropathy.
We investigated the hypothesis that alcohol-induced changes of the immune system result in IgA nephropathy (IAN). Wistar rats were infused with liquid diet containing alcohol: "alcoholics." Control rats received an isocaloric diet with glucose instead of alcohol. IAN was diagnosed by mesangial IgA deposition. When compared to controls, serum IgA in alcoholic rats with IAN had a fourfold increase and a twofold increase in alcoholics without IAN. The intestinal lamina propria showed overall lymphocyte depletion in alcoholic rats. The decrease was not uniform for all the lymphocyte subgroups: it resulted in a relative increase in IgA-B cells in alcoholic rats with IAN but not in alcoholic rats without IAN. No significant differences were observed between alcoholic and control rats in the percentages of spleen lymphocyte subtypes. We suggest that dysfunction of the mucosal immune system may be related to the induction of IAN in chronic alcohol consumption.
Smith
S M
SM
University of New Mexico, School of Medicine, Department of Pathology, Albuquerque.
Tokuda
S
S
Tsukamoto
H
H
D000437:Alcoholism / Q000150:complications*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D002452:Cell Count; D004195:Disease Models, Animal; D000431:Ethanol / Q000097:blood; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D007107:Immune System / Q000503:physiopathology; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D016130:Immunophenotyping; D009092:Mucous Membrane / Q000276:immunology*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000033:anatomy & histology; D013601:T-Lymphocytes / Q000166:cytology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000431:Ethanol