title: Melanocyte-marker-HMB-45 is regularly expressed in angiomyolipoma of the kidney.
abstract: HMB-45 (melanocytic cell-specific monoclonal antibody) immunoreactivity was investigated in 10 cases of angiomyolipoma (AML) (1 with massive regional lymph node involvement) of the kidney and detected in all of them. No HMB-45 immunoreactivity was found in other tumors of the region which can occasionally be confused with AML, such as renal cell carcinoma, Wilms' tumor, and retroperitoneal sarcoma (leiomyosarcoma and liposarcoma). These findings indicate that HMB-45 is not a melanocyte-restricted marker and suggest that its expression might be useful in distinguishing AML from other tumors of the kidney and retroperitoneum.
authors.affiliation: Institute of Pathologic Anatomy, University of Verona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pea
authors.forename: F
authors.initials: F
authors.lastname: Bonetti
authors.forename: G
authors.initials: G
authors.lastname: Zamboni
authors.forename: G
authors.initials: G
authors.lastname: Martignoni
authors.forename: M
authors.initials: M
authors.lastname: Riva
authors.forename: R
authors.initials: R
authors.lastname: Colombari
authors.forename: A
authors.initials: A
authors.lastname: Mombello
authors.forename: M
authors.initials: M
authors.lastname: Bonzanini
authors.forename: A
authors.initials: A
authors.lastname: Scarpa
authors.forename: C
authors.initials: C
authors.lastname: Ghimenton
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000276:immunology; D003937:Diagnosis, Differential; D006391:Hemangioma / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000276:immunology*; D008067:Lipoma / Q000175:diagnosis / Q000276:immunology*; D008544:Melanocytes / Q000276:immunology*; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis / Q000276:immunology; D012509:Sarcoma / Q000175:diagnosis / Q000276:immunology; D009396:Wilms Tumor / Q000175:diagnosis / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor