Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS.
In vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) was used to measure phosphorus metabolism in the brains of manic patients treated with lithium carbonate. The phosphomonoester (PME) peak was elevated in the manic state in patients with DSM-IIIR bipolar disorder compared to the euthymic state and to drug-free normal controls. Elevation of the PME peak may be caused by lithium-induced accumulation of inositol 1-phosphate in the brain.
Kato
T
T
Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
Shioiri
T
T
Takahashi
S
S
Inubushi
T
T
D000328:Adult; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000378:metabolism* / Q000523:psychology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010716:Phosphatidylinositols / Q000378:metabolism*; D011569:Psychiatric Status Rating Scales
D010716:Phosphatidylinositols; D016651:Lithium Carbonate