[Hydrophobic parameters of certain coumarins in studies of structure-activity relationship].
The hydrophobic nature of drugs, very important feature in determination of biological activity, is in Hansch's approach characterized by the logarithm of partition coefficient (log P) determined in n-octanol -water system, or calculated from hydrophobic constants pi (Hansch) or f (Rekker). Those as well as other parameters of hydrophobicity (log k'w, RMw or chi-connectivity index) were correlated with the spasmolytic and cytostatic activity of some coumarins.
Bieganowska
M L
ML
Katedra Chemii Nieorganicznej i Analitycznej Akademii Medycznej, Lublinie.
Głowniak
K
K
D000970:Antineoplastic Agents / Q000737:chemistry; D003374:Coumarins / Q000737:chemistry*; D010276:Parasympatholytics / Q000737:chemistry; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D003374:Coumarins; D010276:Parasympatholytics
Parametry hydrofobowości niektórych kumaryn w badaniach zalezności struktura-aktywność.