Effects of alprazolam on fear-related behavioral, hormonal, and catecholamine responses in infant rhesus monkeys.
We tested the effects of various doses of the triazolobenzodiazepine alprazolam on behavioral, hormonal, and neurochemical responses of infant rhesus monkeys under three conditions of separation from their mothers: alone, in the presence of a human who stared at them, and in the presence of a human who avoided eye contact. Alprazolam affected stress-induced responses in all three of these classes. Unrelated to its effects on the stress response, alprazolam appears to reduce the function of brain dopamine systems.
Kalin
N H
NH
Department of Psychiatry, University of Wisconsin School of Medicine, Madison 53792.
Shelton
S E
SE
Turner
J G
JG
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000525:Alprazolam / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002395:Catecholamines / Q000134:cerebrospinal fluid; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D005239:Fear / Q000187:drug effects*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D011863:Radioimmunoassay
D002395:Catecholamines; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone; D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone; D000525:Alprazolam