title: The superoxide dismutase-like activity of some copper(II) complexes derived from tridentate Schiff bases.
abstract: Oxygen free radicals are the final or intermediate products of many metabolic reactions. Of greatest significance to the organism are superoxide anion radical (O2-.), hydrogen peroxide (H2O2), hydroxyl radical (.OH), singlet oxygen (1O2) etc. A proper ratio between both production and breakdown of oxy-radicals is essential for the maintenance of a dynamic equilibrium of vital processes. The superoxide dismutases protect cells against toxic influence of the superoxide. In addition, some square-pyramidally pentacoordinated copper(II) complexes, derived from tridentate Schiff bases of the N-salicylideneaminoalcanoate type, show remarkable SOD-like activity. A selected set of complexes of this type have been tested: potassium [aqua-(N-salicylideneglutamato) cuprate] (L- and D,L-form), potassium [(isothiocyanato)-(N-salicylideneglycinato) cuprate], potassium [(isothiocyanato)-(N-salicylidene-D,L-alaninato) cuprate], potassium [(isothiocyanato)-(N-salicylidene-beta-alaninato) cuprate] and potassium [(isocyanato)-(N-salicylideneglycinato) cuprate]. Our results suggest that the copper complexes are not only antioxidants, but may also possess anti-inflammatory, cytostatic and radioprotective properties.
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Medicine, ComeniusUniversity, Bratislava, Czechoslovakia.
authors.forename: L
authors.initials: L
authors.lastname: Bergendi
authors.forename: J
authors.initials: J
authors.lastname: Krätsmár-Smogrovic
authors.forename: Z
authors.initials: Z
authors.lastname: Duracková
authors.forename: I
authors.initials: I
authors.lastname: Zitnanova
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D002384:Catalysis; D003300:Copper / Q000378:metabolism*; D016166:Free Radical Scavengers; D005609:Free Radicals; D006801:Humans; D008956:Models, Chemical; D008958:Models, Molecular; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D012545:Schiff Bases; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D009942:Organometallic Compounds; D012545:Schiff Bases; D013481:Superoxides; D003300:Copper; D013482:Superoxide Dismutase; D010100:Oxygen