title: Serum bile acids in relation to disease activity and intake of dietary fibers in juvenile ulcerative colitis.
abstract: Serum concentrations of primary bile acids were determined at different disease activities in juvenile ulcerative colitis and in healthy age-matched controls. In patients with ulcerative colitis in clinical remission, serum levels of bile acids were also studied after long-term intake (6 months) of dietary fibers (wheat fiber and ispaghula, respectively) in a double-blind randomized cross-over study. Blood samples were taken in the morning after an overnight fasting and for 4 h postprandially after a standardized test meal. Determinations of bile acids were made by radioimmunoassays. Patients with total colitis in the active phase had significantly higher serum levels of cholic and chenodeoxycholic acids 4 h postprandially compared with control children. After long-term intake of ispaghula, significantly higher (although not different from controls) serum levels of cholic acid were found 2 and 3 h postprandially, whereas wheat fibers did not affect serum bile acid concentrations. These results may suggest an increased absorption of unconjugated bile acids in the diseased colon and a minimal influence of dietary fibers on serum bile acid concentrations.
authors.affiliation: Department of Pediatrics, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Ejderhamn
authors.forename: B
authors.initials: B
authors.lastname: Strandvik
mesh_terms: D000293:Adolescent; D002635:Chenodeoxycholic Acid / Q000097:blood*; D002648:Child; D019826:Cholic Acid; D002793:Cholic Acids / Q000097:blood*; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy*; D004043:Dietary Fiber / Q000627:therapeutic use*; D004311:Double-Blind Method; D006801:Humans; D011620:Psyllium / Q000627:therapeutic use; D011863:Radioimmunoassay; D013997:Time Factors; D014908:Triticum
chemical_list: D002793:Cholic Acids; D004043:Dietary Fiber; D002635:Chenodeoxycholic Acid; D011620:Psyllium; D019826:Cholic Acid