[The activity and properties of Na,K-ATPase in the erythrocytes and the Na-pump inhibitor in the plasma of subjects with borderline arterial hypertension].
The activity and properties of Na,K-ATPase in erythrocytes and their membrane preparations (ghosts) from 34 subjects with borderline hypertension and 21 normotensive controls were studied. The Na,K-ATPase activity was found to be by 43% lower as compared to control group. No changes in the Na,K-ATPase activity were revealed in the ghosts of borderline subjects. This suggests that the plasma of borderline subjects contains an inhibitor of Na,K-ATPase. The plasma level of sodium pump inhibitor was measured in 21 borderline hypertensive subjects. It was found to be about 19% compared with the control group. These findings suggest presence of Na,K-ATPase inhibitor in the plasma of borderline subjects, which is likely to be involved in the development of hypertension.
Maslova
M N
MN
Ogorodnikova
L E
LE
Titkov
Iu S
IuS
D000328:Adult; D004910:Erythrocyte Membrane / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000097:blood* / Q000502:physiology*
D000254:Sodium-Potassium-Exchanging ATPase
Aktivnost' i svoĭstva Na,K-ATFazy v éritrotsitakh i ingibitor Na-nasosa v plazme u lits s pogranichnoĭ arterial'noĭ gipertenzieĭ.