[Chromosomal resistance of plague agent to quinolones].
The nature of increasing chromosomal resistance to quinolones was studied in a model of the plague microbe. Five virulent strains of the natural plague microbe (Y. pestis) were used in the experiment: 363 (1/1479), 231, 2385, 2442 and 2444. The one-stage procedure for isolation of the mutants was applied. It was shown that the frequency of the one-stage mutants resistant to oxalinic acid, pefloxacin and ciprofloxacin amounted to 10(-9)-10(-11) and was 2 to 3 orders of magnitude lower than that of the mutants resistant to nalidixic acid. Two types of the plague microbe mutants resistant to the quinolones were detected: those resistant to the quinolones to the generations (Nalr-phenotype) and those resistant to the representatives of the 3rd generation quinolones (Nals-phenotype). The quinolones were not efficient in the treatment of albino mice with experimental plague caused by the quinolone-resistant forms of the plague microbe.
Kasatkina
I V
IV
Shcherbaniuk
A I
AI
Makarovskaia
L N
LN
Padeĭskaia
E N
EN
D000818:Animals; D002876:Chromosomes, Bacterial / Q000187:drug effects*; D003470:Culture Media; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial / Q000235:genetics; D066298:In Vitro Techniques; D051379:Mice; D008957:Models, Genetic; D009154:Mutation / Q000187:drug effects* / Q000235:genetics; D010930:Plague / Q000188:drug therapy / Q000235:genetics / Q000382:microbiology*; D015363:Quinolones / Q000494:pharmacology* / Q000627:therapeutic use; D015010:Yersinia pestis / Q000187:drug effects* / Q000235:genetics / Q000648:ultrastructure
D003470:Culture Media; D015363:Quinolones
Khromosomnaia ustoĭchivost' chumnogo mikroba k khinolonam.