Lipoprotein(a) reduction by N-acetylcysteine.
Lipoprotein(a), a complex of low-density lipoprotein linked by disulphide bridges with apo(a), is associated with atherosclerotic disease when present at very high plasma concentrations. In vitro, N-acetylcysteine (NAC) dissociates this complex. In two patients with high Lp(a) levels NAC lowered plasma Lp(a) from 58 to 20 mg/dl and from 59 to 18 mg/dl: reductions of this order have not hitherto been achieved either by drugs or by diet.
Gavish
D
D
Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York, NY 10021-6399.
Breslow
J L
JL
D000111:Acetylcysteine / Q000494:pharmacology*; D000906:Antibodies / Q000032:analysis; D001161:Arteriosclerosis / Q000097:blood; D004032:Diet; D004341:Drug Evaluation; D006801:Humans; D066298:In Vitro Techniques; D017270:Lipoprotein(a); D008074:Lipoproteins / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D008970:Molecular Weight
D000906:Antibodies; D017270:Lipoprotein(a); D008074:Lipoproteins; D000111:Acetylcysteine