title: Evaluation of the KCL-163 ELISA test for detecting antibodies against hepatitis C virus in patients with non-A, non-B chronic hepatitis.
abstract: A specific ELISA test (KCL-163) for detecting anti-hepatitis C virus antibody (anti-HCV) has been developed (Kaketsuken). Using the KCL-163, 183 serum samples obtained from patients with non-A, non-B hepatitis (NANBH) were examined. We also tested and compared results with Ortho HCV ELISA (C100) and C825 ELISA. Of these 183 samples, 139 (76%), 121 (66%), and 88 (48%) were positive with KCL-163, C100 and C825, respectively. These results showed that there were patients with NANBH caused by HCV who were seronegative in C100 ELISA. KCL-163 ELISA is applicable for the diagnosis of HCV infection in these patients.
authors.affiliation: Third Department of Internal Medicine, Kumamoto University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Fujiyama
authors.forename: S
authors.initials: S
authors.lastname: Kawano
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Mizuno
authors.forename: S
authors.initials: S
authors.lastname: Nonaka
mesh_terms: D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005069:Evaluation Studies as Topic; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006526:Hepatitis C / Q000175:diagnosis*; D006801:Humans; D012698:Serologic Tests / Q000379:methods
chemical_list: D006508:Hepatitis Antibodies