Cell cycle kinetics analysis of HeLa cells exposed to aphidicolin: computer simulation.
A computer simulation model was developed and used to analyze the inhibitory effect of aphidicolin on the proliferation of Hela cells. Simulation results were compared with actual experimental results [Pedrali-Noy et al. (1980) Nuc. Acid Res. 8, 377] and were found to be in good agreement. Also, the simulation showed that aphidicolin caused cells to be accumulated at the G1/S boundary and that recruitment and synchrony occurred.
Abed
S Y
SY
Department of Industrial Engineering, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
elAssouli
S M
SM
Ozkul
O S
OS
Alidrisi
M
M
Amer
M
M
D016590:Aphidicolin / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D002478:Cells, Cultured; D003198:Computer Simulation; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D012984:Software
D016590:Aphidicolin