title: CD4+ monocyte counts in persons with HIV-1 infection: an early increase is followed by a progressive decline.
abstract: In this study, we asked whether there is a difference in the number of CD4+ and CD4- peripheral blood monocytes as CD4+ T cells decrease during HIV-mediated immunodeficiency. Monocytes and T cells from 90 HIV-positive and 43 HIV-negative persons were analyzed by flow cytometry. The 90 HIV-positive patients represented the entire spectrum of CD4+ T-cell counts. We report that as CD4+ T cells decrease, the number of CD4+ monocytes decrease in parallel. Moreover, significantly higher CD4+ monocyte counts were observed in persons with early stage HIV disease, i.e., greater than 800 CD4+ T cells/mm3, than in HIV-negative persons with greater than 800 CD4+ T cells/mm3. Potential implications of these findings are discussed.
authors.affiliation: Department of Medicine, Wilford Hall USAF Medical Center, Lackland AFB, San Antonio, Texas.
authors.forename: D R
authors.initials: DR
authors.lastname: Lucey
authors.forename: R E
authors.initials: RE
authors.lastname: Hensley
authors.forename: W W
authors.initials: WW
authors.lastname: Ward
authors.forename: C A
authors.initials: CA
authors.lastname: Butzin
authors.forename: R N
authors.initials: RN
authors.lastname: Boswell
mesh_terms: D000704:Analysis of Variance; D015704:CD4 Antigens / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005434:Flow Cytometry; D006679:HIV Seropositivity / Q000097:blood*; D015497:HIV-1; D006801:Humans; D007958:Leukocyte Count; D009000:Monocytes / Q000276:immunology*
chemical_list: D015704:CD4 Antigens