Testosterone and cyproterone acetate modulate peripheral but not central benzodiazepine receptors in rats.
Sixteen days of testosterone acetate (TA) treatment in male rats induced an increase in the densities of peripheral benzodiazepine receptors (PBR) in the adrenal and Cowper's glands and a decrease in PBR density in the testis. TA did not alter PBR density in the heart, cerebral cortex, or pituitary, or central benzodiazepine receptor (CBR) density in the cerebral cortex or hypothalamus. The antiandrogenic agent cyproterone acetate induced a decrease in PBR density in the testis, adrenal, and pituitary, but did not affect PBR density in Cowper's glands, heart, or cerebral cortex, or CBR density in the cerebral cortex or hypothalamus. In all of the above organs, affinity values did not change following the treatment with both agents. The receptoral changes may be relevant to the physiological and neurobehavioral effects of the chronic exogenous androgenic and antiandrogenic treatment.
Amiri
Z
Z
Rappaport Family Institute for Research in the Medical Sciences, Technion-Israel Institute of Technology, Haifa, Israel.
Weizman
R
R
Katz
Y
Y
Burstein
O
O
Edoute
Y
Y
Lochner
A
A
Gavish
M
M
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D015536:Down-Regulation / Q000187:drug effects; D005445:Flunitrazepam / Q000378:metabolism; D007016:Hypophysectomy; D007546:Isoquinolines / Q000378:metabolism; D008297:Male; D010525:Peripheral Nerves / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology*; D015854:Up-Regulation / Q000187:drug effects
D000726:Androgen Antagonists; D007546:Isoquinolines; D011963:Receptors, GABA-A; D013739:Testosterone; D017373:Cyproterone Acetate; D005445:Flunitrazepam; D003534:Cyproterone; C037850:PK 11195