Assessment of common idiotype PR4-Id in serial bleeds from lupus patients.
Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression was not simply related to total immunoglobulin levels and the controlling mechanisms of idiotype expression on different isotypes remain a matter of conjecture.
Pilcher
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C
Department of Rheumatology Research, University College & Middlesex Hospital Medical School, London.
Williams
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W
Isenberg
D A
DA
D000974:Antibodies, Antinuclear / Q000097:blood*; D004277:DNA, Single-Stranded / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007130:Immunoglobulin Idiotypes / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*
D000974:Antibodies, Antinuclear; D004277:DNA, Single-Stranded; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M