A subpopulation of the v-erb A oncogene protein, a derivative of a thyroid hormone receptor, associates with heat shock protein 90.
The v-erb A oncogene of avian erythroblastosis virus is derived from a host gene for a thyroid hormone receptor and is able to block differentiation of erythroid cells and modify the growth properties of fibroblasts. Unlike its host cell progenitor, the v-erb A protein is found in both cytoplasmic and nuclear fractions of the cell. I report here that the cytoplasmic form of the v-erb A protein is associated in a higher molecular weight complex with heat shock protein 90, the same polypeptide found in association with the unliganded steroid receptors and with the soluble forms of the src oncogene.
Privalsky
M L
ML
Department of Microbiology, University of California, Davis 95616.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D002645:Chickens; D002850:Chromatography, Gel; D003432:Cross-Linking Reagents; D003593:Cytoplasm / Q000378:metabolism; D015180:Electrophoresis, Gel, Two-Dimensional; D006360:Heat-Shock Proteins / Q000378:metabolism*; D046911:Macromolecular Substances; D008970:Molecular Weight; D018774:Oncogene Proteins v-erbA; D011485:Protein Binding; D011988:Receptors, Thyroid Hormone / Q000378:metabolism*; D015682:Retroviridae Proteins, Oncogenic / Q000378:metabolism*
D003432:Cross-Linking Reagents; D006360:Heat-Shock Proteins; D046911:Macromolecular Substances; D018774:Oncogene Proteins v-erbA; D011988:Receptors, Thyroid Hormone; D015682:Retroviridae Proteins, Oncogenic