title: Vitamin D receptors and compensatory tissue growth in spontaneously diabetic BB rats.
abstract: Untreated diabetic (BB) rats exhibited compensatory intestinal growth which was associated with hyperplasia and was accompanied by an increase in unoccupied vitamin D receptors. Although vitamin D receptors were increased, low circulating 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] prevented amplification of the action of 1,25(OH)2D3, as evidenced by reductions in calbindin D-9K and alkaline phosphatase activity in the BB rat intestine compared to control. In the kidney, a lesser degree of compensatory growth was observed which was not associated with hyperplasia, and no significant effect of diabetes on vitamin D receptors or calbindin D-28K was observed. These studies suggest tissue-specific changes in 1,25(OH)2D3 metabolism during spontaneous diabetes which may be related to the hyperplasia which occurs during compensatory tissue growth.
authors.affiliation: Department of Biochemistry, School of Medicine, University of Ottawa, Ont., Canada.
authors.forename: L A
authors.initials: LA
authors.lastname: Stone
authors.forename: V M
authors.initials: VM
authors.lastname: Weaver
authors.forename: M E
authors.initials: ME
authors.lastname: Bruns
authors.forename: S
authors.initials: S
authors.lastname: Christakos
authors.forename: J
authors.initials: J
authors.lastname: Welsh
mesh_terms: D000818:Animals; D064026:Calbindins; D002117:Calcitriol / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006965:Hyperplasia; D007422:Intestines / Q000473:pathology / Q000502:physiology*; D007668:Kidney / Q000737:chemistry; D008297:Male; D051381:Rats; D011913:Rats, Inbred BB; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000032:analysis*; D064030:S100 Calcium Binding Protein G / Q000378:metabolism
chemical_list: D064026:Calbindins; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D064030:S100 Calcium Binding Protein G; D002117:Calcitriol; D002118:Calcium