[Immunologic status of alcoholic patients with pulmonary tuberculosis].
Monoclonal antibodies were used to study the T and B immunity systems in 60 alcoholic patients suffering from pulmonary tuberculosis. The patients with that combined pathology demonstrated marked immunodeficiency as regards the T system and an increase of humoral immunity. It is assumed that one of the main causes of immunodeficiency lies in the blockade of the differentiation of T cells at the stage of T prothymocytes. The rise of the level of humoral immunity is connected to a decline of T suppressors. Administration of thymalin to patients with associated alcoholism and pulmonary tuberculosis was found to be highly effective.
Aliev
N A
NA
Guseĭnov
Sh G
ShG
Khavinson
V Kh
VKh
Seryĭ
S V
SV
D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000276:immunology*; D000911:Antibodies, Monoclonal; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D008231:Lymphopenia / Q000175:diagnosis / Q000209:etiology*; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000276:immunology*
D000911:Antibodies, Monoclonal
Immunologicheskiĭ status bol'nykh alkogolizmom, stradaiushchikh tuberkulezom legkikh.