The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release.
Ferreira
S H
SH
Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brasil.
Duarte
I D
ID
Lorenzetti
B B
BB
D000698:Analgesia; D000818:Animals; D001120:Arginine / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism*; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*; D009952:Ornithine / Q000031:analogs & derivatives / Q000494:pharmacology; D010793:Phthalazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D010793:Phthalazines; D009569:Nitric Oxide; C065027:N(G)-iminoethylornithine; C002385:linsidomine; D009020:Morphine; D001120:Arginine; D008981:Molsidomine; D009952:Ornithine; C052490:MY 5445; D006152:Cyclic GMP; D008751:Methylene Blue