Neurovirulent strains of herpes simplex virus type 1 are not necessarily competent for reactivatable latency.
Ability of two neurovirulent strains (F and +GC (LPV) Miyama) of herpes simplex virus type 1 (HSV-1) to establish and maintain reactivatable latency in trigeminal ganglia (TG) was compared after intranasal inoculation of mice. The +GC (LPV) Miyama strain showed a very low rate of virus reactivation in explant cultures of TG, while the F strain showed a high rate of reactivation. These data indicate that neurovirulent strains of HSV-1 are not always competent for reactivatable latency, although most virulent strains of HSV-1 thus far reported were competent for reactivatable latency.
Arao
Y
Y
Department of Virology, Okayama University Medical School, Japan.
Hatano
A
A
Yamada
M
M
Uno
F
F
Nii
S
S
D000281:Administration, Intranasal; D000818:Animals; D051379:Mice; D009154:Mutation; D018139:Simplexvirus / Q000235:genetics / Q000472:pathogenicity*; D012668:Trigeminal Ganglion / Q000382:microbiology*; D014774:Virulence / Q000502:physiology; D014775:Virus Activation / Q000502:physiology*