title: In vivo measurement of proton diffusion in the presence of coherent motion.
abstract: Measurement of the self-diffusion coefficient D of water in tissue has been performed traditionally using the technique proposed by Stejskal and Tanner. A variant of that technique is shown here, employing flow-compensated gradients that significantly reduce the sensitivity to small coherent motions that are common in body imaging. An interleaved sequence with four values of diffusion-sensitizing gradient (b) minimizes registration errors. Eddy currents and other systematic errors are reduced, permitting the measurement of standards in an imaging context within 5% of nonimaging values in the literature. The flow-compensated sequence permits the measure of D for tissues in the abdominal cavity of the rat. We present in vivo measurements of D for the following rat tissues; liver, kidney (cortex), kidney (medulla) muscle, brain, fat.
authors.affiliation: Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: G A
authors.initials: GA
authors.lastname: Johnson
authors.forename: J H
authors.initials: JH
authors.lastname: Maki
mesh_terms: D000096:Acetone; D000818:Animals; D004058:Diffusion; D004121:Dimethyl Sulfoxide; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009068:Movement; D011522:Protons; D051381:Rats; D014867:Water
chemical_list: D011522:Protons; D014867:Water; D000096:Acetone; D004121:Dimethyl Sulfoxide