The amino aldehydes produced by spermine and spermidine oxidation with maize polyamine oxidase have anti-leishmanial effect.
Purified maize polyamine oxidase bound to hydroxylapatite was utilized as an enzymatic reactor to produce oxidized spermidine and spermine. The oxidation products showed a consistent inhibitory activity on Leishmania infantum in mice. 1,3-diaminopropane showed a much lower activity. Moreover chemically prepared 4-aminobutyraldehyde had a similar ED50 to that of oxidized spermidine. It is concluded that among the compounds arising from polyamine oxidation those with the greatest anti-leishmanial effect are 4-aminobutyraldehyde and 1-(3-aminopropyl)-4-aminobutyraldehyde.
Cona
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Dipartimento di Biologia Vegetale, Università La Sapienza, Rome, Italy.
Federico
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R
Gramiccia
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M
Orsini
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S
Gradoni
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L
D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002384:Catalysis; D017886:Durapatite; D006882:Hydroxyapatites / Q000737:chemistry; D007896:Leishmaniasis / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D010084:Oxidation-Reduction; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000737:chemistry*; D013095:Spermidine / Q000737:chemistry*; D013096:Spermine / Q000737:chemistry*; D003313:Zea mays / Q000201:enzymology*; D000097667:Polyamine Oxidase
D000447:Aldehydes; D000981:Antiprotozoal Agents; D017886:Durapatite; D006882:Hydroxyapatites; D000587:Oxidoreductases Acting on CH-NH Group Donors; D013095:Spermidine; D013096:Spermine; D000097667:Polyamine Oxidase