title: The cDNA for the heart/muscle isoform of bovine cytochrome c oxidase subunit VIa encodes a presequence.
abstract: We have used mixed oligonucleotide probes to isolate a cDNA for the heart/muscle isoform of cytochrome c oxidase (COX) subunit VIa (COX VIa-H) from a bovine heart cDNA library in lambda gt10. This cDNA, and a second one isolated upon rescreening, predict a 97 amino acid COX VIa precursor protein comprised of a 12 amino acid, basic presequence plus an 85 residue mature VIa protein. The presence of a presequence contrasts with the rat heart COX VIa cDNA.
authors.affiliation: Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor 48109-0616.
authors.forename: E O
authors.initials: EO
authors.lastname: Smith
authors.forename: D M
authors.initials: DM
authors.lastname: BeMent
authors.forename: L I
authors.initials: LI
authors.lastname: Grossman
authors.forename: M I
authors.initials: MI
authors.lastname: Lomax
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004247:DNA / Q000235:genetics*; D003576:Electron Transport Complex IV / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics*; D008969:Molecular Sequence Data; D009206:Myocardium / Q000201:enzymology*; D011498:Protein Precursors / Q000235:genetics; D051381:Rats
chemical_list: D007527:Isoenzymes; D011498:Protein Precursors; D004247:DNA; D003576:Electron Transport Complex IV