Platelet [3H]imipramine binding in migraine and tension headache in relation to depression.
Platelet [3H]imipramine binding was measured in 40 migrainous (7 classical and 33 common) and 17 tension headache patients and in 28 normal controls. A significant reduction in Bmax was found in migraine compared with controls (p less than 0.05) but not in tension headache. In migraine, there was no significant relationship between Bmax and depression or anxiety score on the self-rating Hospital Anxiety and Depression (HAD) Scale, suggesting that the reduction in Bmax is a concomitant of migraine itself rather than a manifestation of associated depression. Preliminary evaluation using the Schedule of Affective Disorders and Schizophrenia-Lifetime Version (SADS-L) tended to confirm this conclusion.
Jarman
J
J
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, U.K.
Davies
P T
PT
Fernandez
M
M
Glover
V
V
Steiner
T J
TJ
Rose
F C
FC
Sandler
M
M
D000328:Adult; D001007:Anxiety / Q000097:blood / Q000523:psychology; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D003863:Depression / Q000097:blood* / Q000523:psychology; D005260:Female; D006261:Headache / Q000097:blood* / Q000523:psychology; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000523:psychology; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine