title: Acquisition and quantitation in proton spectroscopy.
abstract: Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the 1H NMR signal, a spatial resolution of 7 X 7 X 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N-acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.
authors.affiliation: Philips Medical Systems, Best, The Netherlands.
authors.forename: P R
authors.initials: PR
authors.lastname: Luyten
authors.forename: A J
authors.initials: AJ
authors.lastname: Mariën
authors.forename: J A
authors.initials: JA
authors.lastname: den Hollander
mesh_terms: D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry / Q000502:physiology; D001927:Brain Diseases / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D011522:Protons; D014867:Water / Q000737:chemistry
chemical_list: D011522:Protons; D014867:Water