DNA breakage caused by hydrogen peroxide produced during the metabolism of 2-methyl-1,4-naphthoquinone (menadione) does not contribute to the cytotoxic action of the quinone.
Cantoni
O
O
Istituto di Farmacologia e Farmacognosia, Università degli Studi di Urbino, Italy.
Fiorani
M
M
Cattabeni
F
F
Bellomo
G
G
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000378:metabolism*; D010618:Phenanthrolines / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014812:Vitamin K / Q000633:toxicity*
D004277:DNA, Single-Stranded; D010618:Phenanthrolines; D013481:Superoxides; D014812:Vitamin K; D006861:Hydrogen Peroxide; D013936:Thymidine