title: Synchronized overproduction of neurotransmitter receptors in diverse regions of the primate cerebral cortex.
abstract: A remarkable diversity of neurotransmitter receptors develops concurrently in disparate areas of the primate cerebral cortex. The density of dopaminergic, adrenergic, serotonergic, cholinergic, and GABAergic receptors (where GABA is gamma-aminobutyric acid) in rhesus monkey reaches a maximum level between 2 and 4 months of age and then declines gradually to adult levels in all layers of sensory, motor, and association regions. The synchronized development of neurotransmitter receptors in diverse layers and regions of the neocortex occurs pari passu with synaptogenesis, demonstrating unusual coordination of biochemical and structural maturation and supporting the hypothesis that the entire cerebral cortex matures as an integrated network, rather than as a system-by-system cascade.
authors.affiliation: Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
authors.forename: M S
authors.initials: MS
authors.lastname: Lidow
authors.forename: P S
authors.initials: PS
authors.lastname: Goldman-Rakic
authors.forename: P
authors.initials: P
authors.lastname: Rakic
mesh_terms: D000375:Aging; D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000254:growth & development* / Q000378:metabolism; D007457:Iodine Radioisotopes; D007700:Kinetics; D008253:Macaca mulatta; D009044:Motor Cortex / Q000254:growth & development / Q000378:metabolism; D009928:Organ Specificity; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013569:Synapses / Q000502:physiology; D014793:Visual Cortex / Q000254:growth & development / Q000378:metabolism
chemical_list: D007457:Iodine Radioisotopes; D017981:Receptors, Neurotransmitter