Inhibition of virus attachment to CPK cells by monoclonal antibody to transmissible gastroenteritis virus.
Five MAbs, which recognized E2 glycoprotein of TGE virus TO-163 and showed neutralizing activity, were examined to see if they inhibit virus attachment to the susceptible cells (CPK cells). Only one (160/4) MAb blocked the virus attachment to the cells, indicating that the inhibition of virus attachment is one of important mechanisms of neutralizing by antibody.
Honda
E
E
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
Mase
M
M
Okazaki
K
K
Kumagai
T
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D001667:Binding, Competitive; D002448:Cell Adhesion; D002460:Cell Line; D005760:Transmissible gastroenteritis virus / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral