Kidney graft survival in rats without immunosuppressants after intrathymic glomerular transplantation.
Isolated glomeruli from Brown-Norway (RT1n) rat kidney were inoculated into the thymus of 6 incompatible Lewis (RT1(1] rats pretreated for 2 days with 40 mg/kg oral cyclosporin daily and given 2.5 mg/kg subcutaneous dexamethasone at inoculation. 10 days later the left kidney from the Brown-Norway donor used to prepare glomeruli was transplanted orthotopically to the Lewis (RT1(1] rat that had received intrathymic glomeruli. Donor-specific unresponsiveness allowed the renal allograft to survive indefinitely without further immunosuppression. 6 control Lewis rats treated as above except that medium alone was injected intrathymically rejected a renal allograft within 7-9 days.
Remuzzi
G
G
Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
Rossini
M
M
Imberti
O
O
Perico
N
N
D000818:Animals; D003524:Cyclosporins / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004231:Diuresis / Q000502:physiology; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D006085:Graft Survival; D007108:Immune Tolerance; D007678:Kidney Glomerulus / Q000276:immunology / Q000637:transplantation*; D016030:Kidney Transplantation; D008297:Male; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D013950:Thymus Gland / Q000276:immunology; D013997:Time Factors
D003524:Cyclosporins; D003907:Dexamethasone