title: The effects of intramuscularly administered vitamin D3, 25- and 1 alpha-hydroxycholecalciferol in cows on plasma mineral content, plasma 25-hydroxycholecalciferol and on mineral deposits in soft tissues.
abstract: The investigations were carried out to evaluate potential side effects of a prophylaxis with high doses of vitamin D3 and vitamin D metabolites in parturient paresis. For this reason, 10(7) IU vitamin D3 (= 250 mg), 4 mg 25-OHD3 or 420 micrograms 1 alpha-OHD3 were applied to non-gravid dairy cows at the end of lactation. The application was repeated 3 times at one week intervals and the changes of the mineral concentration and 25-OHD were measured in the plasma. The pathomorphological changes in the cardio-vascular system and other organs were examined macro- and microscopically. The application of vitamin D3 and 25-OHD3 led to an immediate and continuous increase of the 25-OHD concentration in the plasma. On the other hand, administration of 1 alpha-OHD3 resulted in a decrease of the 25-OHD level. After the application of vitamin D3 and 1 alpha-OHD3, the Ca and Pi concentration increased significantly. After 25-OHD3, the Ca concentration decreased below the initial level in the second week. The administration of all 3 compounds led to a significant decrease of the Mg concentration after the first injection. The administration of vitamin D3 and 1 alpha-OHD3 resulted in a significantly more pronounced calcinosis of inner organs while after the application of 25-OHD3 only occasionally calcium deposits were observed in the vascular system.
authors.affiliation: Veterinary Practice Kamin, Children's Hospital, Friedrich Schiller University, Jena.
authors.forename: H
authors.initials: H
authors.lastname: Zepperitz
authors.forename: G
authors.initials: G
authors.lastname: Jahreis
authors.forename: H
authors.initials: H
authors.lastname: Kiupel
authors.forename: V
authors.initials: V
authors.lastname: Hesse
mesh_terms: D000818:Animals; D002112:Calcifediol / Q000097:blood / Q000494:pharmacology*; D002417:Cattle / Q000378:metabolism*; D002762:Cholecalciferol / Q000494:pharmacology*; D005260:Female; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008903:Minerals / Q000097:blood / Q000378:metabolism*
chemical_list: D006887:Hydroxycholecalciferols; D008903:Minerals; D002762:Cholecalciferol; D002112:Calcifediol; C008088:alfacalcidol