Oxygen-regulated steps in the Rhodobacter capsulatus tetrapyrrole biosynthetic pathway.
The effect of exogenous aminolevulinate and porphobilinogen on protoporphyrin accumulation in Rhodobacter capsulatus was measured. Oxygen inhibited protoporphyrin accumulation in strain AJB456, a bchH mutant, even in the presence of exogenous aminolevulinate, suggesting that some step in the formation of protoporphyrin from aminolevulinate is regulated by oxygen. In contrast, in the presence of exogenous porphobilinogen, oxygen did not inhibit protoporphyrin accumulation. The results presented in this study indicate that oxygen regulates the formation of porphobilinogen from aminolevulinate.
Biel
A J
AJ
Department of Microbiology, Louisiana State University, Baton Rouge 70803.
D000622:Aminolevulinic Acid / Q000494:pharmacology; D001429:Bacteriochlorophylls / Q000096:biosynthesis; D010100:Oxygen / Q000378:metabolism*; D011162:Porphobilinogen / Q000494:pharmacology; D011524:Protoporphyrins / Q000378:metabolism; D011758:Pyrroles / Q000378:metabolism*; D016354:Rhodobacter capsulatus / Q000378:metabolism*; D045725:Tetrapyrroles
D001429:Bacteriochlorophylls; D011524:Protoporphyrins; D011758:Pyrroles; D045725:Tetrapyrroles; D011162:Porphobilinogen; D000622:Aminolevulinic Acid; D010100:Oxygen