Incidence of hepatitis C virus infection in burn patients: detection of anti-C100, anti-C33c and anti-Core antibodies.
Anti-hepatitis C virus antibodies were searched for in 45 burnt patients, at the time of burn injury and more than 6 months after burn injury. HCV infection was detected in 18% as a consequence of the numerous transfusions of blood or blood derivatives used during the post-burn treatment. Five patients displayed evidence of anti-C100, anti-C33c and anti-Core antibodies together; two patients had only anti-C100 and anti-C33c antibodies, and the last one showed only anti-Core antibodies. Chronic hepatitis was observed in 83% of HCV infections. Kinetics of appearance of anti-HCV antibodies varied between patients. Anti-Core is generally the first to be detected at high levels; however, in at least one case it was detected only two and a half months after C100 and C33c antibodies.
Coursaget
P
P
Institut de Virologie de Tours, Faculté de Pharmacie, France.
Lesage
G
G
Simpson
B
B
Mayelo
V
V
Le Cann
P
P
D000410:Alanine Transaminase / Q000097:blood; D002056:Burns / Q000150:complications* / Q000276:immunology; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D065227:Transfusion Reaction
D006508:Hepatitis Antibodies; D000410:Alanine Transaminase