Reproductive disorders in female rats infected with sialodacryoadenitis virus.
Effects of sialodacryoadenitis virus infection on the reproduction of Wistar and Sprague-Dawley (SD) rats were studied. Estrous cycle was considerably out of order in about 40% of infected rats of both strains, starting on days 4 to 20 postinfection and persisting for 2 to 12 days. Of Wistar and SD dams infected on day 0 of gestation about 30% and 10% of the fetuses were found dead, while only 4 and 3% of non-infected dams. In severely diseased Wistar and SD dams infected on day 15 of gestation, the offspring showed death rates of 57% and 13%, respectively, because of inadequate nursing.
Utsumi
K
K
Research Laboratories, Dainippon Pharmaceutical CO., Ltd., Osaka, Japan.
Maeda
K
K
Yokota
Y
Y
Fukagawa
S
S
Fujiwara
K
K
D000818:Animals; D003333:Coronaviridae Infections / Q000503:physiopathology*; D004971:Estrus; D005260:Female; D005313:Fetal Death / Q000662:veterinary; D005865:Gestational Age; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction