title: Inhibition of baclofen-induced hypothermia in mice by the novel GABAB antagonist CGP 35348.
abstract: This study shows that the selective GABAB antagonist CGP 35348 had no effect on body temperature in mice in doses up to 300 mg/kg i.p. However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i.p.) but not that produced by the GABA-mimetic progabide (200 mg/kg i.p.); the benzodiazepine agonist loprazolam (3 mg/kg i.p.); the alpha 2-agonist UK 14,304 (1 mg/kg i.p.) nor the mu-opioid agonist morphine (30 mg/kg i.p.). These findings, showing selective antagonism of GABAB receptors by CGP 35348, confirm that this compound may be a valuable tool for exploration of GABAB receptor function in vivo.
authors.affiliation: Reckitt & Colman Psychopharmacology Unit, School of Medical Sciences, Bristol, England.
authors.forename: H C
authors.initials: HC
authors.lastname: Jackson
authors.forename: D J
authors.initials: DJ
authors.lastname: Nutt
mesh_terms: D000818:Animals; D001418:Baclofen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D058787:GABA-A Receptor Antagonists; D007035:Hypothermia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009943:Organophosphorus Compounds / Q000494:pharmacology*
chemical_list: D058787:GABA-A Receptor Antagonists; D009943:Organophosphorus Compounds; C066430:CGP 35348; D001418:Baclofen