title: The ATC (ataxia-telangiectasia complementation group C) locus localizes to 11q22-q23.
abstract: The multisystem autosomal recessive disease ataxia-telangiectasia (A-T) is determined by several genes, as evidenced by the existence of four complementation groups in this disorder. Using linkage analysis, the ATA (A-T complementation group A) gene was previously localized to chromosome 11, region q22-q23. Analysis of the segregation of RFLP markers from this region in a Jewish-Moroccan family assigned to group C indicates that the ATC (A-T complementation group C) gene localizes to chromosome 11q22-q23 as well.
authors.affiliation: Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Ziv
authors.forename: G
authors.initials: G
authors.lastname: Rotman
authors.forename: M
authors.initials: M
authors.lastname: Frydman
authors.forename: J
authors.initials: J
authors.lastname: Dagan
authors.forename: T
authors.initials: T
authors.lastname: Cohen
authors.forename: T
authors.initials: T
authors.lastname: Foroud
authors.forename: R A
authors.initials: RA
authors.lastname: Gatti
authors.forename: Y
authors.initials: Y
authors.lastname: Shiloh
mesh_terms: D001260:Ataxia Telangiectasia / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11; D005260:Female; D005816:Genetic Complementation Test; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length