Simultaneous occurrence of SIADH, secondary hypogonadism and alopecia universalis in a woman with IDDM.
Syndrome of inappropriate secretion of antidiuretic hormone (SIADH), hypothalamic hypogonadism and alopecia universalis occurred in a 31-year-old female with insulin-dependent diabetes mellitus (IDDM). Despite various clinical investigations and careful observation for 20 months, the cause and pathogenesis of SIADH and hypothalamic hypogonadism were not elucidated. The complex of these disorders had not been described. The presence of IDDM and alopecia universalis, in which an autoimmune process has been assumed to be involved, is interesting in considering the pathogenesis of the SIADH and hypothalamic hypogonadism.
Yasutomo
Y
Y
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Yoshida
A
A
Noritake
M
M
Nemoto
Y
Y
Kugai
N
N
Nagata
N
N
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000505:Alopecia / Q000097:blood / Q000209:etiology*; D002996:Clomiphene / Q000494:pharmacology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007006:Hypogonadism / Q000097:blood / Q000209:etiology*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000209:etiology*; D007328:Insulin / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011388:Prolactin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014667:Vasopressins / Q000097:blood
D007328:Insulin; D013963:Thyroid Hormones; D014667:Vasopressins; D002996:Clomiphene; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D006854:Hydrocortisone