title: Urinary excretion of free toluenediamines in a patient with polyurethane-covered breast implants.
abstract: We report the detection of free 2,4-toluenediamine in urine of a patient implanted with polyurethane-covered breast implants. Samples were collected on several dates, ranging from 21 days to seven months after the insertion of the implants, and these samples all showed the presence of free 2,4-toluenediamine at a concentration of about 1 micrograms/L. The chemical was not found in a urine sample collected before implantation. This finding is important for risk assessment of cancer in patients with this type of breast implant because the chemical is a suspected carcinogen. Free 2,6-toluenediamine, an isomer, was also found in all samples from this patient.
authors.affiliation: Department of Laboratory Medicine, Foothills Hospital, Calgary, Alberta, Canada.
authors.forename: S C
authors.initials: SC
authors.lastname: Chan
authors.forename: D C
authors.initials: DC
authors.lastname: Birdsell
authors.forename: C Y
authors.initials: CY
authors.lastname: Gradeen
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000601:surgery; D005260:Female; D006801:Humans; D016462:Mammaplasty / Q000009:adverse effects*; D010655:Phenylenediamines / Q000652:urine*; D011140:Polyurethanes; D019736:Prostheses and Implants / Q000009:adverse effects*
chemical_list: D010655:Phenylenediamines; D011140:Polyurethanes; C010914:2,4-diaminotoluene