The in-vitro activity of tosufloxacin, a new fluorinated quinolone, compared with that of ciprofloxacin and temafloxacin.
Tosufloxacin was highly active in vitro against most isolates of Enterobacteriaceae. It was slightly less active than ciprofloxacin for most species but more active than temafloxacin. It was the most active agent against Acinetobacter spp., Xanthomonas maltophilia and some Pseudomonas spp. but was slightly less active than ciprofloxacin against the fluorescent pseudomonads. Tosufloxacin was highly active against strains of Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae and Campylobacter coli/jejuni. It was the most active of the fluoroquinolones tested against staphylococci (MICs 0.016-0.25 mg/L), streptococci (MICs 0.06-1 mg/L) and enterococci (MICs 0.12-4 mg/L). Tosufloxacin was also the most active quinolone tested against anaerobic bacteria and, with the exception of a few isolates of Bacteroides spp. and some clostridia, all anaerobes had tosufloxacin MICs less than 1 mg/L.
King
A
A
Microbiology Department, UMDS St. Thomas' Hospital, London, UK.
Bethune
L
L
Phillips
I
I
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001420:Bacteria, Aerobic / Q000187:drug effects; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology*; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*; D015363:Quinolones / Q000494:pharmacology
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D015363:Quinolones; C054745:temafloxacin; D002939:Ciprofloxacin; C055185:tosufloxacin