Inverse relationship between CSF TRH concentrations and the TSH response to TRH in abstinent alcohol-dependent patients.
The authors performed the thyrotropin-releasing hormone (TRH) stimulation test and measured CSF concentrations of TRH in 13 abstinent alcohol-dependent subjects. They found an inverse correlation between the thyrotropin (TSH) response to TRH and endogenous CSF TRH concentrations. This finding supports the hypothesis that as the concentration of CSF TRH increases, anterior pituitary TRH receptor density decreases, resulting in a blunted TSH response to TRH stimulation.
Adinoff
B
B
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md.
Nemeroff
C B
CB
Bissette
G
G
Martin
P R
PR
Linnoila
M
M
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D015536:Down-Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D018025:Receptors, Thyrotropin-Releasing Hormone; D013695:Temperance; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000134:cerebrospinal fluid*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D017981:Receptors, Neurotransmitter; D018025:Receptors, Thyrotropin-Releasing Hormone; D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine