title: Nuclear targeting sequences--a consensus?
abstract: Nuclear targeting sequences are essential for the transport of proteins into the nucleus. The seven-amino-acid nuclear targeting sequence of the SV40 large T antigen has been regarded as the model; however, many nuclear targeting sequences appear to be more complex. We suggest in this review that, despite this diversity, a consensus bipartite motif can be identified.
authors.affiliation: Wellcome Trust/Cancer Research Campaign Institute of Cancer and Development Biology, Cambridge.
authors.forename: C
authors.initials: C
authors.lastname: Dingwall
authors.forename: R A
authors.initials: RA
authors.lastname: Laskey
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000957:Antigens, Viral, Tumor / Q000378:metabolism; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D016384:Consensus Sequence; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000378:metabolism*; D012689:Sequence Homology, Nucleic Acid; D013539:Simian virus 40 / Q000378:metabolism
chemical_list: D000957:Antigens, Viral, Tumor; D002352:Carrier Proteins; D009687:Nuclear Proteins