Inhibitory effect of aclarubicin on endothelium-dependent relaxation of rat aorta.
The effects of aclarubicin on endothelium-dependent and -independent vasorelaxations were investigated in aortic strips from rats. Aclarubicin (5.9-23.6 microM) inhibited endothelium-dependent relaxation and the increment of the cyclic GMP level in aortic strips in response to acetylcholine but not the endothelium-independent relaxation and the increase of cyclic GMP level in response to sodium nitroprusside. Aclarubicin also inhibited endothelium-dependent relaxations in response to ATP and calcium ionophore A23187. These results suggest that aclarubicin can inhibit endothelium-dependent relaxation by acting somewhere distal to receptor stimulation in vascular endothelial cells.
Wakabayashi
I
I
Department of Hygiene, Hyogo College of Medicine, Japan.
Sakamoto
K
K
Hatake
K
K
D000109:Acetylcholine / Q000494:pharmacology; D015250:Aclarubicin / Q000494:pharmacology*; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D004730:Endothelium, Vascular / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D009599:Nitroprusside; D015250:Aclarubicin; D006152:Cyclic GMP; D000109:Acetylcholine