[Dynamics of the activity of cytochrome oxidase and glutathione level in tissues of rats, poisoned with potassium cyanides and nitriles].
Rats were intoxicated with LD50 of potassium cyanide and some nitriles. Content of glutathione in brain and liver tissues and activity of cytochrome oxidase in brain were studied. Activity of brain cytochrome oxidase was inhibited in rats intoxicated with cyanide, acrylonitrile and valeronitrile. All the nitriles studied reduced the tissue glutathione content. Cyanides did not exhibit any effects on glutathione concentration.
Kutsenko
S A
SA
Shilov
V V
VV
D000818:Animals; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D009570:Nitriles / Q000506:poisoning*; D010084:Oxidation-Reduction; D011190:Potassium Cyanide / Q000506:poisoning*; D051381:Rats
D009570:Nitriles; D003576:Electron Transport Complex IV; D005978:Glutathione; D011190:Potassium Cyanide
Dinamika aktivnosti tsitokhrom oksidazy i soderzhaniia glutationa v tkaniakh krys, otravlennykh tsianistym kaliem i nitrilami.