[Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia].
Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.
Kastner
P
P
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U/184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médecine, Strasbourg, France.
Perez
A
A
Lutz
Y
Y
Rochette-Egly
C
C
Gaub
M P
MP
Chambon
P
P
D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000737:chemistry* / Q000235:genetics; D015513:Oncogene Proteins / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry* / Q000235:genetics; D014212:Tretinoin / Q000737:chemistry* / Q000378:metabolism
D009363:Neoplasm Proteins; D015513:Oncogene Proteins; D011956:Receptors, Cell Surface; D011993:Recombinant Fusion Proteins; D014212:Tretinoin
Protéines de fusion entre PML et RAR-alpha dans les leucémies aiguës à promyélocytes.