Synthesis and characterization of [186Re]rhenium(V)dimercaptosuccinic acid: a possible tumour radiotherapy agent.
[186Re]Re(V)DMSA, a beta-emitting analogue of the tumour imaging radiopharmaceutical pentavalent [99mTc]Tc(V)DMSA of possible value in tumour therapy, is readily prepared by stannous reduction of [186Re]ReO4 in the presence of dimercaptosuccinic acid at 100 degrees C using a commercial DMSA kit as used for renal imaging with 99mTc, and purified using a disposable sample preparation column. The complex has been identified as [ReO(DMSA)2] by NMR, optical and i.r., spectroscopy and elemental analysis.
Bisunadan
M M
MM
Biological and Chemical Laboratories, The University, Canterbury, Kent.
Blower
P J
PJ
Clarke
S E
SE
Singh
J
J
Went
M J
MJ
D006801:Humans; D007202:Indicators and Reagents; D007536:Isomerism; D015394:Molecular Structure; D009369:Neoplasms / Q000532:radiotherapy*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011868:Radioisotopes / Q000627:therapeutic use*; D012211:Rhenium / Q000627:therapeutic use*; D004113:Succimer / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D009942:Organometallic Compounds; D011868:Radioisotopes; C069609:rhenium(V)dimercaptosuccinic acid; D012211:Rhenium; D004113:Succimer