[Clinical and pathogenetic observations on children with chronic mononucleosis].
Epstein-Barr virus is seldom the causative agent of a prolonged atypical illness, known as chronic mononucleosis syndrome, characterized by a persistent pattern of clinical manifestations and by a defective immune response to specific viral antigens. This paper refers about 6 children for whom clinical and serological findings suggest the chronic Epstein-Barr virus infection. The authors believe that this chronic state might be explained by the unusual antibody pattern to EBV virus, with the persistent presence of anti-EA and the absence of anti-EBNA titers, expression of a reduced EBV-specific cytotoxic T cell activity.
Cataldo
F
F
Clinica Pediatrica R. di Palermo, Università di Palermo, Italia.
Ammatuna
P
P
Bellia
L
L
Sammartano
F
F
Violante
M
M
Albeggiani
A
A
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D015673:Fatigue Syndrome, Chronic / Q000276:immunology* / Q000382:microbiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D013601:T-Lymphocytes / Q000502:physiology
D000914:Antibodies, Viral; D007136:Immunoglobulins
Rilievi clinico-patogenetici su bambini con mononucleosi cronica.