[Lipid peroxidation of the cerebrospinal fluid in patients with arterial cerebral aneurysms].
It was established from study of lipid peroxidation (LOP) products in 19 patients (16 with subarachnoid hemorrhages /SAH/ resulting from rupture of arterial aneurysms and 3 with arterial hemorrhages in the "cold" period) that their content was significantly higher in patients with a history of 2 or 3 SAH than in those who had suffered from a single SAH. The LOP level in the c.s.f. in patients of both groups differed significantly from that in the c.s.f. of patients without SAH. It was also established that the content of LOP products in patients with an unfavourable outcome of the disease was more than twice that in patients with a favourable course and outcome of the disease. Administration of antioxidants (alpha-tocopherol and ascorbic acid) inhibited the LPO processes, which was manifested by a decrease of the content of malonyl dialdehyde in the c.s.f.
Promyslov
M Sh
MSh
Levchenko
L I
LI
Demchuk
M L
ML
Miakota
A E
AE
D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000134:cerebrospinal fluid; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology
D000975:Antioxidants; D008315:Malondialdehyde
Issledovanie perekisnogo okisleniia lipidov likvora u bol'nykh s arterial'nymi anevrizmami golovnogo mozga.