Lisinopril-hydrochlorothiazide combination compared with the monocomponents in elderly hypertensive patients.
The fixed combination of lisinopril 20 mg and hydrochlorothiazide 12.5 mg (L/HCTZ) was compared with each of the monocomponents in a multicentre, double-blind, randomized, parallel-group study involving elderly patients with mild to severe hypertension. At the end of the trial, a total of 278 patients had completed 8 weeks of treatment. SBP reduction from baseline in the L/HCTZ group was significantly greater, sitting and standing, compared with both the monotherapy groups. Sitting DBP reduction from baseline in the L/HCTZ group was significantly greater than in the hydrochlorothiazide group. Uric acid levels were raised significantly more in the L/HCTZ group compared with the lisinopril group, and the fall in potassium levels were significantly smaller in the L/HCTZ group compared with the hydrochlorothiazide group. Safety and tolerability were equivalent for the three groups.
Hart
W
W
Reinier de Graaf Gasthuis, Delft, The Netherlands.
D000368:Aged; D000369:Aged, 80 and over; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004311:Double-Blind Method; D004338:Drug Combinations; D004656:Enalapril / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000009:adverse effects; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D017706:Lisinopril; D008297:Male; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D004338:Drug Combinations; D006852:Hydrochlorothiazide; D004656:Enalapril; D017706:Lisinopril