title: Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial.
abstract: Hyperthermia delivered by scanned focused ultrasound was combined with external beam radiation to treat 15 patients with primary malignant tumors of the brain. A preliminary craniectomy was performed to avoid attenuation of the ultrasound beam by the skull, and multiple thermal sensors were employed to ascertain intratumoral temperatures. The target temperature was 42.5 degrees C at the tumor boundary. This was attained at more than one point during every complete treatment, while a mean temperature in excess of 42 degrees C was achieved within the scanned tumor volume during at least 1 treatment in 11 patients. Technical problems and toxicities are described.
authors.affiliation: Department of Surgery (Section of Neurosurgery), University of Arizona.
authors.forename: A N
authors.initials: AN
authors.lastname: Guthkelch
authors.forename: L P
authors.initials: LP
authors.lastname: Carter
authors.forename: J R
authors.initials: JR
authors.lastname: Cassady
authors.forename: K H
authors.initials: KH
authors.lastname: Hynynen
authors.forename: R P
authors.initials: RP
authors.lastname: Iacono
authors.forename: P C
authors.initials: PC
authors.lastname: Johnson
authors.forename: E A
authors.initials: EA
authors.lastname: Obbens
authors.forename: R B
authors.initials: RB
authors.lastname: Roemer
authors.forename: J F
authors.initials: JF
authors.lastname: Seeger
authors.forename: D S
authors.initials: DS
authors.lastname: Shimm
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D005909:Glioblastoma / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy / Q000628:therapy; D014464:Ultrasonic Therapy / Q000009:adverse effects / Q000295:instrumentation