Receptor-mediated mitogenic signals and lung cancer.
Most lung cancers are simultaneously stimulated by several autocrine and paracrine growth factors. Diseases resulting in excessive production of these factors and/or changes in the receptors, second messengers, or genes comprising their signal transduction pathways can thus result in the stimulation of continuous cell proliferation characteristic of cancer. Some carcinogenic N-nitrosamines mimic the stimulatory effect of cell-type-specific growth factors by binding to their receptors, and in this way mediate their selective carcinogenic effects. In this review I discuss the significance of receptor-mediated mitogenic signal transduction pathways for the initiation and progression of lung cancer, and describe novel lung cancer therapeutics that target components of these pathways.
Schüller
H M
HM
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
D000109:Acetylcholine / Q000502:physiology; D002273:Carcinogens / Q000494:pharmacology / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D004249:DNA Damage; D006133:Growth Substances / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000503:physiopathology*; D008934:Mitogens / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000494:pharmacology / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology; D009490:Neurosecretory Systems / Q000503:physiopathology; D009602:Nitrosamines / Q000494:pharmacology / Q000633:toxicity; D011956:Receptors, Cell Surface / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects; D012907:Smoking; D014407:Tumor Cells, Cultured / Q000187:drug effects
D002273:Carcinogens; D006133:Growth Substances; D008934:Mitogens; D009363:Neoplasm Proteins; D009479:Neuropeptides; D009602:Nitrosamines; D011956:Receptors, Cell Surface; D011978:Receptors, Nicotinic; D000109:Acetylcholine