title: [Sudden blindness in an AIDS patient. Simultaneous infection with cytomegalovirus and herpes simplex viruses and development of malignant non-Hodgkin lymphoma].
abstract: A 50 year old patient with non-diagnosed HIV-infection at onset of his illness developed impairment of vision and temporary double vision combined with severe hemianopsia. With normal fundus and suspicious Herpes simplex iritis therapy with Acyclovir was started. Primarily the patient showed a good response to the therapy and loss of vision could be prevented. After 4 weeks CMV-retinitis developed. In spite of Gancyclovir therapy manifestation of total loss of vision after 6 weeks. Autopsy demonstrated signs of simultaneous a CMV-infection of the retina and a herpes simplex-infection of the optic nerve combined with a Non-Hodgkin-Lymphoma of the optic tract.
authors.affiliation: Institut für Neuropathologie, Universität Freiburg.
authors.forename: C
authors.initials: C
authors.lastname: Zimmer
authors.forename: I
authors.initials: I
authors.lastname: Nieuwenhuis
authors.forename: M
authors.initials: M
authors.lastname: Danisevskis
authors.forename: H
authors.initials: H
authors.lastname: Spiegel
authors.forename: L L
authors.initials: LL
authors.lastname: Hansen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D001766:Blindness / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002829:Choroid / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007635:Keratitis, Dendritic / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012160:Retina / Q000473:pathology; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D012173:Retinitis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D014794:Visual Fields / Q000502:physiology
vernacular_title: Plötzliche Erblindung bei einem AIDS-Patienten. Gleichzeitige Infektion mit Zytomegalie und Herpes simplex-Viren und Auftreten eines malignen Non-Hodgkin-Lymphoms.