Induction of thyroid proliferative changes in rats treated with antithyroid compound.
This study was designed to investigate the histologic changes in goitrogen-induced thyroid growth of the rat. The animals were orally treated by 1% potassium perchlorate except the controls and were sacrificed in intervals ranging from 1 to 12 months. The thyroid weight increased progressively along the treatment and after 2 months showed a diffuse homogenous hypertrophy and hyperplasia of follicular cells, decreased amount of colloid and increased vascularity. After sixth month of treatment true nodules appeared with complex morphology.
Fernandez Rodriguez
A
A
Department of Pathology, University of Seville, Spain.
Galera Davidson
H
H
Salguero Villadiego
M
M
Moreno Fernandez
A
A
Martin Lacave
I
I
Fernandez Sanz
J
J
D000818:Animals; D005260:Female; D006965:Hyperplasia; D006984:Hypertrophy; D010472:Perchlorates / Q000633:toxicity*; D011188:Potassium / Q000633:toxicity; D017680:Potassium Compounds; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects* / Q000254:growth & development; D013964:Thyroid Neoplasms / Q000139:chemically induced*; D016606:Thyroid Nodule / Q000139:chemically induced*
D010472:Perchlorates; D017680:Potassium Compounds; C009006:potassium perchlorate; D011188:Potassium