Intraindividual variation of beta 2-adrenergic receptors on mononuclear leukocytes and their relationships with endogenous plasma catecholamines in man.
The interindividual and intraindividual variations of both MNL beta 2-adrenergic receptor density and dissociation constant of binding were evaluated in 19 healthy volunteers. In addition the possible relationships between catecholamine plasma levels and MNL beta 2-adrenergic receptor density were studied in 8 of these subjects. The volunteers were studied three times with ten days' interval. There was a significant inverse relationship between receptor density and norepinephrine plasma levels, only. Neither epinephrine nor dopamine were correlated with receptor density. Interindividual coefficient of variation was 29.57%. The mean value of the intraindividual coefficients of variation was 14.1%, while the mean value of the analytical coefficients of variation was 10%. Our results are at some variance with data in the literature and may contribute to elucidate the role of MNL beta 2-adrenergic receptors as an index of sympathetic function in man.
Pende
A
A
Istituto Scientifico di Medicina Interna, Università degli Studi di Genova, Ospedale S. Martino, Italy.
Musso
N R
NR
Vergassola
C
C
Ioverno
A
A
Galbariggi
G
G
Lotti
G
G
D000328:Adult; D002395:Catecholamines / Q000097:blood* / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007206:Individuality; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure*; D008297:Male; D011943:Receptors, Adrenergic, beta / Q000032:analysis* / Q000502:physiology; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000502:physiology
D002395:Catecholamines; D011943:Receptors, Adrenergic, beta