[Immunomodulating properties of non-steroidal anti-inflammatory drugs].
There has been studied the influence of a number of nonsteroidal antiinflammatory agents (NSAID ) on the humoral immune response of mice in immunization with erythrocytic and viral antigen. It has been found out that NSAID have immunomodulating effect, stimulating humoral immune response (4-iodantipyrine, 4-bromantipyrine) or suppressing it (butadione, sodium salicylate). Apparently the mechanism of NSAID ++ immunostimulating effect is related to the inhibition of T-suppressors ++ function by the latter ones.
Evstropov
A N
AN
Gritsenko
L N
LN
Orolovskaia
I A
IA
Saratikov
A S
AS
Prishchep
T P
TP
Iavorovskaia
V E
VE
D000276:Adjuvants, Immunologic; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000921:Antibody-Producing Cells / Q000166:cytology* / Q000187:drug effects; D015478:Antigens, Heterophile / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology*; D004770:Enterovirus / Q000276:immunology*; D066298:In Vitro Techniques; D051379:Mice; D012756:Sheep; D013154:Spleen / Q000166:cytology* / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015478:Antigens, Heterophile; D000956:Antigens, Viral
Immunomoduliruiushchie svoĭstva nesteroidnykh protivovospalitel'- nykh sredstv.