title: cAMP signal transduction pathways regulating development of Dictyostelium discoideum.
abstract: Dictyostelium discoideum development is regulated through receptor/G protein signal transduction using cAMP as a primary extracellular signal. Signaling pathways will be discussed as well as the regulation and function of individual cAMP receptors and G alpha subunits. Finally potential downstream targets including protein kinases and nuclear events will be explored.
authors.affiliation: Laboratory of Cellular and Developmental Biology, NIDDK/NIH, Bethesda, Maryland 20892.
authors.forename: A R
authors.initials: AR
authors.lastname: Kimmel
authors.forename: R A
authors.initials: RA
authors.lastname: Firtel
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D002465:Cell Movement / Q000235:genetics; D000242:Cyclic AMP / Q000502:physiology*; D004023:Dictyostelium / Q000235:genetics / Q000254:growth & development*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D008954:Models, Biological; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D011953:Receptors, Cyclic AMP / Q000235:genetics; D015290:Second Messenger Systems
chemical_list: D005656:Fungal Proteins; D011953:Receptors, Cyclic AMP; D000242:Cyclic AMP; D011494:Protein Kinases; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases