NGF receptor-mediated reduction in axonal NGF uptake and retrograde transport following sciatic nerve injury and during regeneration.
Injury to the rat sciatic nerve leads to the induction of nerve growth factor (NGF) receptors on the denervated Schwann cells and their disappearance on the regenerating axons of the axotomized, normally NGF-sensitive sensory and sympathetic neurons. This disappearance in the axonal expression and retrograde transport of NGF receptors is associated with a similarly dramatic reduction in the axonal uptake and retrograde transport of NGF following axotomy and during regeneration. In view of the massive NGF synthesis occurring in the injured nerve, these results suggest that, while sensory and sympathetic neurons are the primary targets of NGF in the normal peripheral nervous system, the denervated Schwann cells may become its primary target in the aftermath of nerve injury.
Raivich
G
G
Department of Neuromorphology, Max-Planck-Institute for Psychiatry, Martinsried, Germany.
Hellweg
R
R
Kreutzberg
G W
GW
D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000502:physiology; D001692:Biological Transport; D007700:Kinetics; D009414:Nerve Growth Factors / Q000493:pharmacokinetics*; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000502:physiology*; D017475:Receptors, Nerve Growth Factor; D012584:Sciatic Nerve / Q000293:injuries* / Q000378:metabolism
D009414:Nerve Growth Factors; D011956:Receptors, Cell Surface; D017475:Receptors, Nerve Growth Factor