title: Analgesia produced by pituitary ACTH and dopaminergic transmission in the arcuate.
abstract: Analgesia (NAA) caused by nonacupuncture point (abdominal muscle) stimulation after lesioning the analgesia inhibitory system (AIS) or treating the subject with proglumide was abolished by hypophysectomy or adrenalectomy. The final sector of the NAA afferent pathway from the nonacupuncture point to the pituitary gland and the initial sector of the descending pain inhibitory system were found in the anterior and posterior arcuate nucleus (A-HARN and P-HARN), respectively. Analgesia caused by ACTH microinjected into the P-HARN disappeared after denervation of the A-HARN, but that caused by dopamine did not. Firing rates of P-HARN neurons were increased by nonacupuncture point simulation (NAPS) after lesion of the AIS or treatment with proglumide. The NAPS responsive neurons also responded to ultramicroinjected dopamine, but not to ultramicroinjected ACTH. Both NAA and NAPS responsive neuron activity that were abolished by hypophysectomy were restored by concurrent application of NAPS and intraperitoneal ACTH. Reduction of sodium ions due to adrenalectomy was found to abolish NAA. It was concluded that NAA production involves dopaminergic transmission in the HARN and ACTH acting presynaptically on this transmission.
authors.affiliation: Department of Physiology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Takeshige
authors.forename: M
authors.initials: M
authors.lastname: Tsuchiya
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.forename: S
authors.initials: S
authors.lastname: Guo
mesh_terms: D000311:Adrenal Glands / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000502:physiology*; D000698:Analgesia / Q000379:methods*; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000166:cytology / Q000502:physiology*; D003714:Denervation; D004298:Dopamine / Q000502:physiology*; D004558:Electric Stimulation; D008297:Male; D009130:Muscle, Smooth / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012965:Sodium Chloride / Q000494:pharmacology; D013787:Thalamic Nuclei / Q000502:physiology
chemical_list: D012965:Sodium Chloride; D000324:Adrenocorticotropic Hormone; D004298:Dopamine