[Adrenergic effects on the renal function and their mechanisms].
The experiments on rats have shown that the activation of alpha-adrenoceptors decreases the glomerular filtration as well as sodium and water reabsorption against a background of a decrease in the blood content of vasopressin, renin, angiotensin II, aldosterone and a fall of the renal cortex level of thromboxane B2. alpha-, alpha 1- and beta-adrenoceptors blockade decreases diuresis as well as sodium and potassium excretion due to an increase in the level of vasopressin, renin and insulin. The stimulation of beta-adrenoceptors accelerates the glomerular filtration, decreases sodium reabsorption and potassium excretion against a background of an increase in the secretion of vasopressin, renin, insulin and a fall of the blood level of angiotensin II and aldosterone and an elevation of the prostaglandin E2 content in the renal cortex. A conclusion is drawn that the adrenergic regulation of the kidneys is mediated to a considerable degree by hormones which regulate the water-salt metabolism and vascular tonus in vivo.
Krishtal'
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D000818:Animals; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008954:Models, Biological; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects* / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D009638:Norepinephrine; D011224:Prazosin; D010646:Phentolamine
Adrenergicheskie vliianiia na funktsiiu pochek i ikh mekhanizmy.