title: Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity.
abstract: Melanostatin, a new antibiotic with melanin synthesis inhibitor activity, was isolated from the fermentation broth of Streptomyces clavifer No. N924-2. Its structure was determined by spectral analysis and degradation experiments. Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.
authors.affiliation: Bristol-Myers Squibb Research Institute, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ishihara
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: M
authors.initials: M
authors.lastname: Tsunakawa
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: M
authors.initials: M
authors.lastname: Hatori
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Kamei
authors.forename: T
authors.initials: T
authors.lastname: Miyaki
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Oki
mesh_terms: D002855:Chromatography, Thin Layer; D005285:Fermentation; D009075:MSH Release-Inhibiting Hormone / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008546:Melanoma, Experimental; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D012988:Soil Microbiology; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000145:classification* / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
chemical_list: D008543:Melanins; D009075:MSH Release-Inhibiting Hormone; D014442:Monophenol Monooxygenase