[Effects of propranolol on mitosis-inhibiting activity of G2-chalone and adrenaline in cell culture of Ehrlich's ascites tumor].
Chalone-containing preparation from ascite Ehrlich's tumour blocks these cell transition from G2-phase to mitosis and its motion in mitosis in vitro (G2-block, M-block). Adrenaline blocks these cell transition from G2-phase to mitosis. Propranolol raises G2-block of chalone or adrenaline. Consequently this way of chalones action on cell division includes beta-adrenergic receptors influence of preparation on cell motion in mitosis doesn't change with addition of propranolol. Consequently this way of chalone system action on mitosis doesn't include beta-adrenergic receptors.
Antokhin
A I
AI
Popova
N Ia
NIa
Gembitskiĭ
D S
DS
Romanov
Iu A
IuA
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D050150:Chalones; D004837:Epinephrine / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects*; D009930:Organic Chemicals; D011433:Propranolol / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D013997:Time Factors; D014407:Tumor Cells, Cultured
D050150:Chalones; C025912:G(2) chalone; D006131:Growth Inhibitors; D009930:Organic Chemicals; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D004837:Epinephrine
Vliianie propranolola na mitozingibiruiushchuiu aktivnost' G2-keĭlona i adrenalina v kul'ture kletok astsitnoĭ opukholi Erlikha.