[The changes in vascular reactivity during aging].
Adult and old rats and rabbits revealed age-related changes of the reactivity of isolated vessels to catecholamines, vasopressin and acetylcholine. Changes that occurred in the sensitivity of various vascular areas during ageing were irregular. The increase in sensitivity of coronary vessels to vasopressin and rise of concentration of hormones in the blood promoted the development of coronary insufficiency. Stress, catecholamines sharply increased the sensitivity of coronary vessels of old rats to vasopressin. In adult and old rabbits the dyslipoproteinemia altered the sensitivity of aortal smooth muscles to epinephrine, while in old animals it enhanced the contractile effect. The shifts in vascular endothelium were shown to play certain role in the changes of vascular reactivity during ageing. The vasopressin-induced rise of cGMP in the vascular smooth muscles was more obvious in old vs. adult rats.
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D000109:Acetylcholine / Q000494:pharmacology; D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000502:physiology*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology; D014667:Vasopressins / Q000494:pharmacology
D002791:Cholesterol, Dietary; D014667:Vasopressins; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine
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