Central motor pathways conduction after magnetic stimulation of the brain in Cockayne's syndrome.
Central motor pathways conduction abnormalities after magnetic stimulation of the brain are reported in two siblings with Cockayne's syndrome. Reduced amplitude of the responses with large central conduction time were the main changes. These results are consistent with signs of diffuse white matter hypomyelination found on MRI. Conversely, only mild changes in conduction velocity of the peripheral nerves were found. Central nervous system involvement can be more severe than peripheral neuropathy in Cockayne's syndrome.
Cruz Martínez
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Department of Neurophysiology, Hospital La Paz, Madrid, Spain.
Anciones
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D000293:Adolescent; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002531:Cerebellum / Q000473:pathology / Q000503:physiopathology; D002648:Child; D003057:Cockayne Syndrome / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology*; D004574:Electromagnetic Fields; D006801:Humans; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000503:physiopathology; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000294:innervation; D009434:Neural Pathways / Q000503:physiopathology; D010525:Peripheral Nerves / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D011984:Sensory Receptor Cells / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology*