[Persistence of the control of the fluctuations of heart rate in the anesthetized and pithed adult rat. Effect of enteraminergic drugs].
Spontaneous fluctuations in heart rate were analyzed by spectral analysis in the ether anesthetized and pithed adult rat. In order to investigate the changes in the spectral pattern of the fluctuations, the selective 5HT-2 and -3 isoreceptor blockers ritanserin and BRL 43694A were used. In both the experimental conditions, ritanserin blockade led to dose-dependent increased fluctuations in HR low and high frequencies. In both the anesthetized and pithed rats, the low frequency range HR fluctuations were drastically reduced by BRL 43694A.
Bernardi
M
M
I.M.O.-Centro Interuniversitario Interdipartimentale Interazioni Biofisiche e Biochimiche Molecole e Organismi.
Di Sarra
B
B
Montecchiani
G
G
Re
L
L
Rossini
L
L
Tonnini
C
C
D000758:Anesthesia; D000818:Animals; D003655:Decerebrate State / Q000503:physiopathology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004986:Ether; D005260:Female; D017829:Granisetron; D006339:Heart Rate / Q000187:drug effects*; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D016713:Ritanserin; D012702:Serotonin Antagonists / Q000494:pharmacology*
D004986:Ether; D017829:Granisetron; D007191:Indazoles; D010880:Piperidines; D016713:Ritanserin; D012702:Serotonin Antagonists
Persistenza del controllo delle fluttuazioni della frequenza cardiaca nel ratto adulto, anestetizzato e "periferico". Effetti di trattamenti farmacologici enteraminergici.