[Muscarinic-acetylcholine and beta-adrenaline receptors of the retinal and pigment epithelium cells during eye regeneration in tritons].
The development of M-choline and beta-adrenoceptors of retina and pigment epithelium cells has been studied in regenerating newt eye by radioligand analysis. The data obtained have been compared with the histological data. High content of M-choline and beta-adrenoceptors has been observed both in retina, in pigment epithelium of retina-ectomized and control eyes. 7-10 weeks after the operation, incomplete receptors have been observed in the regenerate with incomplete differentiation: they had low binding constants and had non-characteristic bending saturation curves. Pigment epithelium cells could interact with ligands properly. 10-13 weeks after the operation, the values and pattern of binding became similar to that of control retina. The data obtained can be explained by gradual increase in the share of morphologically differentiated cells in retina regenerate.
Grigorian
E N
EN
Moskovkin
G N
GN
D000818:Animals; D004837:Epinephrine / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D009799:Ocular Physiological Phenomena; D010857:Pigment Epithelium of Eye / Q000502:physiology*; D010999:Pleurodeles; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000032:analysis / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D012160:Retina / Q000502:physiology*; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D004837:Epinephrine
Muskarinovye-atsetilkholinovye i beta-adrenalinovye retseptory kletok setchatki i pigmentnogo épiteliia v protsesse regeneratsii glaza u tritonov.