title: Effect of 2-O-stearoyl glycerol-1,3-bisphosphate on in vitro demineralization of dental root surfaces.
abstract: The effect of 2-O-stearoyl glycerol-1,3-bisphosphate (Glydip) on caries lesion formation in root surfaces of sound human third molars was investigated in vitro. For this purpose parts of the root surfaces were treated with Glydip. Adjacent parts of the surfaces were not treated and served as control. Lesions were obtained by demineralization with an acetate buffer of pH 5.0. It was found that Glydip had no inhibiting effect on the rate of lesion formation. Additionally, pretreatments were performed with lauryl sulphate, a chloroform-methanol mixture, an aqueous solution of sodium hypochlorite, and collagenase prior to the treatment with Glydip to enhance the accessibility of the tissue for Glydip. None of these pretreatments or combinations of them revealed an inhibiting effect of Glydip on the rate of caries lesion formation. This result is in contrast to the effect of Glydip on the demineralization of enamel.
authors.affiliation: Department of Biochemistry, University of Nijmegen, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Borggreven
authors.forename: F C
authors.initials: FC
authors.lastname: Driessens
authors.forename: T L
authors.initials: TL
authors.lastname: Hoeks
authors.forename: B
authors.initials: B
authors.lastname: Zwanenburg
mesh_terms: D000134:Acid Etching, Dental; D002725:Chloroform / Q000494:pharmacology; D003731:Dental Caries / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D000432:Methanol / Q000494:pharmacology; D003012:Microbial Collagenase / Q000494:pharmacology; D010742:Phospholipid Ethers / Q000494:pharmacology*; D010756:Phosphoric Acids / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D012973:Sodium Hypochlorite / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology*; D013997:Time Factors; D017001:Tooth Demineralization / Q000473:pathology / Q000503:physiopathology*; D014092:Tooth Root / Q000187:drug effects* / Q000473:pathology
chemical_list: D010742:Phospholipid Ethers; D010756:Phosphoric Acids; D013501:Surface-Active Agents; C069963:Glydip; D012967:Sodium Dodecyl Sulfate; D002725:Chloroform; C028913:dodecyl sulfate; D012973:Sodium Hypochlorite; D003012:Microbial Collagenase; D000432:Methanol