title: Hematological, biochemical and bone scan findings in patients with marrow carcinoma.
abstract: The peripheral blood hematological and biochemical parameters in 60 patients with marrow involvement with carcinoma are described. In all patients the hematologic findings were of anemia (46%), thrombocytopenia (36%), leukocytosis (28%) and leukoerythroblastosis (22%). Elevated serum lactate dehydrogenase (sLDH) and alkaline phosphatase (sALP) occurred in 78% of patients and hypercalcemia in 28% and these abnormal biochemical parameters occurred more frequently with marrow fibrosis. In patients with small cell carcinoma of lung (SCCL) the sLDH was normal in 24% and sALP in 32% and abnormal hematological findings or a raised sLDH occurred more frequently with liver involvement. Bone scan was positive in 49% of patients and the hematological and biochemical parameters in these patients were similar to those of patients with a normal scan. Ten percent of patients with SCCL and marrow involvement had both a normal sLDH and bone scan.
authors.affiliation: Department of Hematology, Alfred Hospital, Prahran, Victoria, Australia.
authors.forename: L J
authors.initials: LJ
authors.lastname: Campbell
authors.forename: M B
authors.initials: MB
authors.lastname: Van der Weyden
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000740:Anemia / Q000097:blood; D001706:Biopsy; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000473:pathology*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002277:Carcinoma / Q000000981:diagnostic imaging*; D018288:Carcinoma, Small Cell / Q000473:pathology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood; D007964:Leukocytosis / Q000097:blood; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D055728:Primary Myelofibrosis / Q000201:enzymology; D011877:Radionuclide Imaging; D013921:Thrombocytopenia / Q000097:blood; D014057:Tomography, X-Ray Computed
chemical_list: D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase