Pneumocystis carinii pneumonia complicating somatostatin therapy of Cushing's syndrome in a patient with metastatic pancreatic islet cell carcinoma and Zollinger-Ellison syndrome.
Described is the case of a 73-yr-old woman with metastatic pancreatic islet carcinoma that manifested initially as Zollinger-Ellison syndrome followed by onset of endogenous Cushing's syndrome, who developed Pneumocystis carinii pneumonia while on therapy with a long-acting somatostatin analog. Although P. carinii pneumonia has been observed in patients with Cushing's syndrome associated with other conditions, this is the first reported case in a patient with Zollinger-Ellison syndrome. Heightened awareness of the possibility of opportunistic infections in patients receiving somatostatin therapy for Cushing's syndrome of any cause, particularly Zollinger-Ellison syndrome, may be warranted.
McQuillen
D P
DP
Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Massachusetts.
Schroy
P C
PC
Hesketh
P J
PJ
Sugar
A M
AM
D007516:Adenoma, Islet Cell / Q000150:complications* / Q000473:pathology; D000368:Aged; D003480:Cushing Syndrome / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D011020:Pneumonia, Pneumocystis / Q000209:etiology*; D013004:Somatostatin / Q000009:adverse effects* / Q000627:therapeutic use; D015043:Zollinger-Ellison Syndrome / Q000150:complications*
D013004:Somatostatin