Reversal of antihypertensive agent-induced postural hypotension with physostigmine.
Physostigmine, administered intravenously, reversed postural hypotension induced by hypotensive agents, guanethidine, clonidine and dopamine2-receptor agonists. Postural hypotension, induced by pentobarbital sodium, was also reversed by physostigmine. Neostigmine reversed postural hypotension induced by clonidine following intracerebroventricular, but not intravenous administration. It is proposed that centrally acting cholinomimetic agents may be used to manage postural hypotension resulting from suppression of sympathetic nervous system activity.
Park
K H
KH
Department of Pharmacology, College of Medicine, University of Iowa, Iowa City 52242.
Long
J P
JP
Cannon
J G
JG
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006145:Guanethidine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007024:Hypotension, Orthostatic / Q000503:physiopathology / Q000517:prevention & control*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D009388:Neostigmine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010424:Pentobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010830:Physostigmine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D013238:Stereotaxic Techniques; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects
D000777:Anesthetics; D000959:Antihypertensive Agents; D011954:Receptors, Dopamine; D009388:Neostigmine; D010830:Physostigmine; D010424:Pentobarbital; D003000:Clonidine; D006145:Guanethidine