title: The status of cytomegalovirus vaccine.
abstract: Live attenuated Towne strain cytomegalovirus vaccine was evaluated in healthy volunteers and renal transplant recipients. Immunization induced humoral and cell-mediated immune responses in both groups, although responses were of a higher magnitude in healthy volunteers. Immunization of candidates for renal transplantation with Towne vaccine significantly reduced the incidence of moderately severe and severe cytomegalovirus disease in high-risk recipients after transplantation. Reactivation of vaccine-strain virus was not detected. While the use of live attenuated Towne strain vaccine for prevention of primary cytomegalovirus infections in solid-organ transplant recipients and pregnant women deserves further consideration, efforts are also under way to develop a subunit cytomegalovirus vaccine.
authors.affiliation: Division of Infectious Diseases and Immunology, Children's Hospital of Philadelphia, Pennsylvania 19104.
authors.forename: S E
authors.initials: SE
authors.lastname: Starr
authors.forename: H M
authors.initials: HM
authors.lastname: Friedman
authors.forename: S A
authors.initials: SA
authors.lastname: Plotkin
mesh_terms: D000914:Antibodies, Viral / Q000096:biosynthesis*; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000517:prevention & control*; D006801:Humans; D007111:Immunity, Cellular; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines