title: [The antigenic properties of hepatitis A virus particles possessing different physicochemical characteristics].
abstract: A modified enzyme immunoassay based on adsorption of antihepatitis A virus (HAV) IgG-HRPO conjugate and monoclonal antibodies to HAV were used to investigate antigenic differences between mature HAV virions and subviral particles with different buoyant densities in CsCl produced in HAV-infected cells. The mature virions (1.34 g/cm3) appeared to have common antigenic determinants with subviral particles (1.20, 1.27, and 1.30 g/cm3) and possess some additional determinants. Nevertheless, both subviral particles and mature virions induced antibodies capable of neutralizing HAV infectivity in tissue culture.
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Kusov
authors.forename: T A
authors.initials: TA
authors.lastname: Nastashenko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kazachkov
authors.forename: M A
authors.initials: MA
authors.lastname: Donets
authors.forename: G K
authors.initials: GK
authors.lastname: Grishina
authors.forename: N P
authors.initials: NP
authors.lastname: Berkova
authors.forename: M S
authors.initials: MS
authors.lastname: Balaian
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000097:blood / Q000276:immunology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006168:Guinea Pigs; D006507:Hepatovirus / Q000276:immunology*; D007114:Immunization; D007124:Immunoenzyme Techniques; D009500:Neutralization Tests; D011817:Rabbits; D014771:Virion / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral
vernacular_title: Antigennye svoĭstva chastits virusa gepatita A, obladaiushchikh razlichnymi fiziko-khimicheskimi kharakteristikami.