[The beta-adrenoceptor and pathophysiological study on acute lung injury induced by oleic acid in rats].
Sixty male Wistar rats were randomized into six groups. In the control and injury group normal saline and oleic acid were injected in tail veins respectively. Dexamethasone, Salviae mitiorrhizae, Ligustrazini and phenobarbitalum natrium were intraperitoneally for the other four groups 15 minutes before the intravenous injection of oleic acid separately. The results showed that the Bmax of beta-adrenoceptor in injury group were decreased markedly and there was correlation between the decreasing of beta-adrenoceptor numbers and pathologic damage in acute lung injury rat. The Bmax of beta-adrenoceptor in cortisone group were similar to control group, which indicated that cortisone is effective to prevent pathologic damage from lung injury by maintenance of the activity of beta-adrenoceptor.
Tian
Y L
YL
General Hospital, PLA, Beijing.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D008168:Lung / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D009829:Oleic Acids; D010634:Phenobarbital / Q000494:pharmacology; D010936:Plant Extracts; D011719:Pyrazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000473:pathology*; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D009829:Oleic Acids; D010936:Plant Extracts; D011719:Pyrazines; D011943:Receptors, Adrenergic, beta; D003907:Dexamethasone; C017953:tetramethylpyrazine; D010634:Phenobarbital