[Mechanisms of resistance to DNA topoisomerase II inhibitors].
Cytotoxicity of anticancer drugs are depended on cellular differences of drug transport processes, drug metabolism or proliferation process including DNA synthesis. Thus, resistance to anticancer drugs is likely due to many cellular changes. Mechanisms of resistance to anticancer drugs have been studied with cells selected for their ability to grow in the presence of drugs. In this paper, the mechanisms of cellular resistance to DNA topoisomerase II inhibitors was described.
Kohno
K
K
Dept. of Biochemistry, Oita Medical School, Japan.
Takano
H
H
Kuwano
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003602:Cytotoxicity, Immunologic; D004351:Drug Resistance; D005047:Etoposide / Q000494:pharmacology; D013713:Teniposide / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000473:pathology
D059005:Topoisomerase II Inhibitors; D005047:Etoposide; D013713:Teniposide