[The prognostic significance of the direct effect in the conservative treatment of small-cell lung cancer].
A tumor response to chemoradiotherapy was studied in 260 patients with small-cell lung carcinoma in situ on the basis of clinical parameters using different regimens of dose fractionation and various levels of total focal doses. Nonclassical irradiation regimens were found superior to routine dose fractionation. At present it seems improbable routine dose fractionation. At present it seems improbable to predict a response of small-cell lung carcinoma to irradiation and polychemotherapy on the basis of clinical parameters in each individual case. A varied response of small-cell cancer to conservative antitumor therapy is likely to be determined by its morphological, biological and genetic heterogeneity.
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D000970:Antineoplastic Agents / Q000627:therapeutic use; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000532:radiotherapy; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012074:Remission Induction
D000970:Antineoplastic Agents
Prognosticheskaia znachimost' neposredstvennogo éffekta pri konservativnom lechenii melkokletochnogo raka legkogo.