Synthesis, characterization, and antitumor activity of 5-iodouracil complexes.
Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells.
Singh
U P
UP
Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi, India.
Singh
B N
BN
Ghose
A K
AK
Singh
R K
RK
Sodhi
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002104:Cadmium / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D008297:Male; D008345:Manganese / Q000737:chemistry; D051379:Mice; D008809:Mice, Inbred C3H; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012510:Sarcoma 180 / Q000188:drug therapy; D013055:Spectrophotometry, Infrared; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry
D000970:Antineoplastic Agents; C100034:iodouracil; D002104:Cadmium; D003035:Cobalt; D008345:Manganese; D014498:Uracil; D003300:Copper; D015032:Zinc