Effects of cytomegalovirus hepatitis on growth, development and nervous system of infants. A follow-up study.
Twenty-seven infants with cytomegalovirus hepatitis were followed up for 15-40 months after onset of the illness. They had recovered from the hepatitis, but microcephaly was present in 2 (7.4%), sensorineural hearing loss in 5 (18.5%), quadriplegia, mental retardation, ventricular septal defect and tooth defects in 1 (3.7%) each. The patients with congenital infection had more severe and complex defects, some with perinatal infection had mild defects, those with postnatally acquired infection had no sequelae. The mean MDI and frequency of expressive language delay in the former group differed significantly from those of the other 2. Five patients still excreted cytomegalovirus in the urine at follow-up.
Fang
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F
Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan.
Dong
Y S
YS
D002657:Child Development; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections; D005260:Female; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000209:etiology; D008297:Male; D008831:Microcephaly / Q000209:etiology; D009420:Nervous System / Q000503:physiopathology*