Use of collagen shields in the treatment of herpetic keratitis.
Eighteen patients with typical Herpes simplex virus dendritic keratitis confirmed by viral isolation were treated with corneal collagen shields presoaked with trifluorothymidine for 15 minutes and trifluorothymidine eye drops 5 times daily. The average healing time was 2.9 days (range 1-7 days). No allergic reactions were observed. Toxic punctate keratitis occurred in 3 eyes. The results of this open study suggest that the effect of collagen corneal shields in conjunction with trifluorothymidine shortens the average epithelial healing time compared with other studies that have used antiviral drugs alone.
Colin
J
J
Brest University Hospital, France.
Malet
F
F
Chastel
C
C
Richard
M C
MC
D000328:Adult; D000368:Aged; D001684:Biological Dressings; D003094:Collagen / Q000627:therapeutic use*; D003315:Cornea / Q000382:microbiology; D004337:Drug Carriers; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011379:Prognosis; D011446:Prospective Studies; D018139:Simplexvirus / Q000302:isolation & purification; D014271:Trifluridine / Q000008:administration & dosage*
D004337:Drug Carriers; D009883:Ophthalmic Solutions; D003094:Collagen; D014271:Trifluridine