Evidence for involvement of endogenous glycine in the induction of long-term potentiation in the dentate gyrus of anesthetized rats.
The role of the glycine site associated with the N-methyl-D-aspartate receptor in the induction of long-term potentiation (LTP) was investigated in the dentate gyrus of anesthetized rats. Administration of a glycine site antagonist, 7-chlorokynurenate (50 mmol i.c.v.), significantly blocked the induction of LTP without affecting baseline responses. LTP was induced normally when 7-chlorokynurenate and D-serine (100 nmol i.c.v.) were administered together. These results suggest clearly that endogenous glycine participates in the induction of LTP in vivo.
Mizutani
A
A
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Saito
H
H
Abe
K
K
D000758:Anesthesia; D000818:Animals; D004558:Electric Stimulation; D005998:Glycine / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D007736:Kynurenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology; D012694:Serine / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine; D007736:Kynurenic Acid; C057013:7-chlorokynurenic acid; D005998:Glycine