[Activity of antibiotics against pigmented and unpigmented variants of Mycobacterium avium-intracellulare].
Efficacy of various antibiotics: amikacin, rifampicin, rifabutin, ciprofloxacin, temafloxacin, erythromycin and clarithromycin was evaluated against pigmented and unpigmented variants of Mycobacterium avium complex isolated from patients with acquired immunodeficiency syndrome. The minimal inhibitory concentrations of antibiotics against unpigmented variants were multiplied by 2 to 16 compared to those of pigmented variants. Observations with intracellularly growing bacteria showed that unpigmented variants were more resistant to antibiotics than variants with a difference of approximately 0.25 a 0.3 log 10 in decrease of viable or bacterial counts. The combinations of temafloxacin or ciprofloxacin with rifabutin and amikacin were most effective against unpigmented variants.
Gevaudan
M J
MJ
Laboratoire de Microbiologie, Hôpital Salvator, Marseille.
Bollet
C
C
Mallet
M N
MN
de Micco
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D047029:Lactams, Macrocyclic; D018942:Macrolides; D015269:Mycobacterium avium Complex / Q000187:drug effects* / Q000302:isolation & purification; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000382:microbiology; D009894:Opportunistic Infections / Q000150:complications; D015363:Quinolones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D047029:Lactams, Macrocyclic; D018942:Macrolides; D015363:Quinolones
Action des antibiotiques sur des variants pigmentés ou non pigmentés de mycobacterium avium-intracellulare.