title: Absence of sustained effects of acute fluoride exposure on cyclic AMP levels in the adult rat.
abstract: Previously published results from studies of the in vivo effects of fluoride on cyclic AMP are contradictory. Because of the important physiological role of cyclic AMP as a "second messenger" in numerous metabolic processes, it was important to clarify the effect of fluoride on cyclic AMP. This study was designed to monitor cyclic AMP levels in the plasma, liver and kidney of rats at intervals of 0.5, 4 and 24 hours following acute intraperitoneal or intubated treatment with a single dose of 15 mg fluoride/kg and to relate cyclic AMP levels to plasma and tissue fluoride concentrations determined at the same time.
authors.affiliation: Oral Health Research Institute, Indiana University School of Dentistry.
authors.forename: A J
authors.initials: AJ
authors.lastname: Dunipace
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: G K
authors.initials: GK
authors.lastname: Stookey
authors.forename: D W
authors.initials: DW
authors.lastname: Allmann
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000032:analysis* / Q000097:blood; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007441:Intubation, Gastrointestinal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000242:Cyclic AMP; D005459:Fluorides