The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts.
The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.
Aberdam
D
D
Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel.
Negreanu
V
V
Sachs
L
L
Blatt
C
C
D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D002471:Cell Transformation, Neoplastic; D004251:DNA Transposable Elements; D015870:Gene Expression; D005801:Genes, Homeobox; D007426:Genes, Intracisternal A-Particle; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000235:genetics; D009857:Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D015183:Restriction Mapping; D014162:Transfection
D004251:DNA Transposable Elements; D012333:RNA, Messenger