title: Energy conservation by succinate decarboxylation in Veillonella parvula.
abstract: Veillonella parvula cannot grow with succinate as sole energy source. However, succinate decarboxylation simultaneous with malate or lactate fermentation increased growth yields by 2.4-3.5 g (mol succinate)-1. Malate was fermented stoichiometrically to acetate and propionate whereas lactate fermentation produced more acetate and considerable amounts of H2. Aspartate was utilized only in the presence of succinate as co-substrate. Methylmalonyl-CoA decarboxylase and ATP-dependent pyruvate carboxylase, but not methylmalonyl-CoA:pyruvate transcarboxylase, were detected in cell-free extracts of malate- or lactate-grown cells. The energetic aspects of these fermentation patterns are discussed.
authors.affiliation: Lehrstuhl Mikrobiologie I, Universität Tübingen, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Denger
authors.forename: B
authors.initials: B
authors.lastname: Schink
mesh_terms: D000085:Acetates / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism; D019878:Carboxyl and Carbamoyl Transferases; D002455:Cell Division; D003653:Decarboxylation; D004734:Energy Metabolism; D005285:Fermentation; D006859:Hydrogen / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008293:Malates / Q000378:metabolism; D008954:Models, Biological; D011422:Propionates / Q000378:metabolism; D011766:Pyruvate Carboxylase / Q000032:analysis; D013386:Succinates / Q000378:metabolism*; D019802:Succinic Acid; D014166:Transferases / Q000032:analysis; D014678:Veillonella / Q000378:metabolism*
chemical_list: D000085:Acetates; D007773:Lactates; D008293:Malates; D011422:Propionates; D013386:Succinates; D001224:Aspartic Acid; D019344:Lactic Acid; D006859:Hydrogen; C030298:malic acid; D019802:Succinic Acid; D014166:Transferases; D019878:Carboxyl and Carbamoyl Transferases; C021580:Methylmalonyl-CoA carboxytransferase; D011766:Pyruvate Carboxylase