[Enhancement of selective drug accumulation and retention in normal and regenerating liver by the use of lipiodol in portal venous infusion in rats].
We studied selective accumulation and retention of lipiodol (LP) and anticancer agents in normal and regenerating liver tissue following portal infusion in rats. Total concentration of Aclarubicin (ACR) and its metabolites in liver tissue was higher in ACR + LP portal infusion group than in ACR portal infusion group both in normal and regenerating liver, concentration of active metabolites of ACR was higher in ACR portal infusion group than in ACR peripheral infusion group. Much higher concentration was found in ACR + LP portal infusion group. Histologic examination revealed more toxic effect on regenerating liver in ACR portal infusion group than in ACR + LP portal infusion group. Oil red staining demonstrated the retention of lipiodol more than 7 days following intraportal infusion in regenerating liver tissue. This study confirms that the ACR + LP portal infusion induces selective accumulation and long-term retention in normal and regenerating liver tissue, and may enhance the antitumor effect of drugs.
Suzuki
H
H
First Department of Surgery, Chiba University, School of Medicine, Japan.
Miyazaki
M
M
Iinuma
K
K
Udagawa
I
I
Koshikawa
H
H
Ito
H
H
Okui
K
K
D015250:Aclarubicin / Q000008:administration & dosage* / Q000378:metabolism; D000818:Animals; D006498:Hepatectomy; D007459:Iodized Oil / Q000008:administration & dosage* / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains
D015250:Aclarubicin; D007459:Iodized Oil