Neuropeptide concentrations in the cerebrospinal fluid of depressed patients treated with electroconvulsive therapy. Corticotrophin-releasing factor, beta-endorphin and somatostatin.
The CSF concentrations of CRF, somatostatin and beta-endorphin were determined in nine patients who fulfilled DSM-III criteria for major depression with psychotic features. CSF samples were obtained at baseline in the depressed state, and again after a course of ECT. Concentrations of both CRF and beta-endorphin decreased after ECT, while the concentration of somatostatin increased, although the latter difference did not attain statistical significance. The increase in CSF concentrations of CRF and beta-endorphin in depressed patients is therefore seen to be state-dependent.
Nemeroff
C B
CB
Department of Psychiatry and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710.
Bissette
G
G
Akil
H
H
Fink
M
M
D000328:Adult; D000368:Aged; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid*; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000523:psychology / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D011569:Psychiatric Status Rating Scales; D013004:Somatostatin / Q000134:cerebrospinal fluid*; D001615:beta-Endorphin / Q000134:cerebrospinal fluid*
D009479:Neuropeptides; D013004:Somatostatin; D001615:beta-Endorphin; D003346:Corticotropin-Releasing Hormone