Neutrophil chemotactic factors.
Polymorphonuclear leukocytes (neutrophils) are recruited to inflammatory sites by a variety of soluble mediators (chemoattractants) that stimulate neutrophil directed migration (chemotaxis). Many neutrophil chemoattractants such as neutrophil activating proteins, leukotriene B4 (LTB4), platelet activating factor, and complement-derived C5a, are generated endogenously by host cells or enzymatic cleavage of host proteins. Other chemoattractants such as N-formyl peptides are generated exogenously by bacteria that invade the host. Oxidative modification of methionine residues or changes in the amino acid sequence of peptide chemoattractants dramatically alter their chemoattractive properties. Many of the well-defined neutrophil chemotactic factors and studies of their structure-function relationships will be reviewed.
Harvath
L
L
Division of Hematology, Food and Drug Administration, Bethesda, MD 20892.
D000818:Animals; D002630:Chemotactic Factors / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D015936:Complement C5a / Q000502:physiology; D006801:Humans; D007249:Inflammation; D007975:Leukotriene B4 / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D010972:Platelet Activating Factor / Q000502:physiology; D010978:Platelet Factor 4 / Q000502:physiology
D002630:Chemotactic Factors; D009479:Neuropeptides; D010972:Platelet Activating Factor; D007975:Leukotriene B4; D010978:Platelet Factor 4; D015936:Complement C5a