Intracerebroventricular pertussis toxin enhances sensitivity to N-methyl-D-aspartate-induced seizures in mice.
The effect of pretreatment with pertussis toxin on N-methyl-D-aspartate (NMDA)-induced seizures was investigated in mice. In animals treated with pertussis toxin (0.5 micrograms/animal i.c.v) five days prior to testing the convulsant ED50 of NMDA was calculated to be 18 mg/kg whereas it was calculated to be 107 mg/kg in sham-treated animals. These results suggest the pertussis toxin enhances sensitivity to NMDA, possibly via its actions on inhibitory G-proteins.
Durcan
M J
MJ
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, DICBR, Bethesda, MD 20892.
Morgan
P F
PF
D000818:Animals; D004357:Drug Synergism; D019204:GTP-Binding Proteins / Q000037:antagonists & inhibitors; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D016202:N-Methylaspartate / Q000008:administration & dosage / Q000494:pharmacology*; D037342:Pertussis Toxin; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced*; D009435:Synaptic Transmission / Q000187:drug effects; D010566:Virulence Factors, Bordetella / Q000008:administration & dosage / Q000633:toxicity*
D016194:Receptors, N-Methyl-D-Aspartate; D010566:Virulence Factors, Bordetella; D016202:N-Methylaspartate; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins