Cation transport and adenosine triphosphatase activity in rat erythrocytes: a comparison of spontaneously hypertensive rats with the normotensive Brown-Norway strain.
The activity of transport adenosine triphosphatases (ATPases) in saponin-treated erythrocytes as well as the passive membrane permeability for 86Rb+ (K+), 45Ca2+ uptake (in the presence of orthovanadate) and the rate of Na(+)-H+ exchange in intact erythrocytes were studied in spontaneously hypertensive rats (SHR), Wistar-Kyoto (WKY) and Brown-Norway (BN.lx) rats. Higher Na+,K(+)-ATPase activity, lower Ca(2+)-ATPase activity, increased passive K+ permeability and greater 45Ca2+ uptake were observed in erythrocytes from SHR compared with BN.lx rats. Similar differences in the last two parameters were also disclosed by a comparison of SHR and WKY rats. The rate of Na(+)-H+ exchange in SHR erythrocytes was greater than in WKY rats but equal to that of BN.lx rats. A genetic analysis did not reveal a significant correlation between Na(+)-H+ exchange rate and blood pressure in F2 SHR x WKY hybrids.
Orlov
S N
SN
School of Biology, Moscow State University, USSR.
Petrunyaka
V V
VV
Pokudin
N I
NI
Kotelevtsev
Y V
YV
Postnov
Y V
YV
Kunes
J
J
Zicha
J
J
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000493:pharmacokinetics; D002412:Cations / Q000493:pharmacokinetics*; D004912:Erythrocytes / Q000378:metabolism*; D006973:Hypertension / Q000378:metabolism*; D007474:Ion Exchange; D008297:Male; D011188:Potassium / Q000493:pharmacokinetics; D011522:Protons; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012964:Sodium / Q000493:pharmacokinetics
D002412:Cations; D011522:Protons; D012964:Sodium; D000251:Adenosine Triphosphatases; D011188:Potassium; D002118:Calcium