title: Ca2+ extrusion across plasma membrane and Ca2+ uptake by intracellular stores.
abstract: The aim of this review is to summarize the various systems that remove Ca2+ from the cytoplasm. We will initially focus on the Ca2+ pump and the Na(+)-Ca2+ exchanger of the plasma membrane. We will review the functional regulation of these systems and the recent progress obtained with molecular-biology techniques, which pointed to the existence of different isoforms of the Ca2+ pump. The Ca2+ pumps of the sarco(endo)plasmic reticulum will be discussed next, by summarizing the discoveries obtained with molecular-biology techniques, and by reviewing the physiological regulation of these proteins. We will finally briefly review the mitochondrial Ca(2+)-uptake mechanism.
authors.affiliation: Laboratory of Molecular Signalling, Department of Zoology, Cambridge, U.K.
authors.forename: L
authors.initials: L
authors.lastname: Missiaen
authors.forename: F
authors.initials: F
authors.lastname: Wuytack
authors.forename: L
authors.initials: L
authors.lastname: Raeymaekers
authors.forename: H
authors.initials: H
authors.lastname: De Smedt
authors.forename: G
authors.initials: G
authors.lastname: Droogmans
authors.forename: I
authors.initials: I
authors.lastname: Declerck
authors.forename: R
authors.initials: R
authors.lastname: Casteels
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
chemical_list: D012964:Sodium; D000252:Calcium-Transporting ATPases; D002118:Calcium