title: IgG subclass distribution of primary and secondary immune responses concomitant with viral infection.
abstract: Infection with mouse hepatitis virus was found to selectively increase the proportion of IgG2a in antibodies elicited by a concomitant administration of unrelated T cell-dependent protein Ag. In contrast, T cell-independent responses were only marginally affected. This isotypic bias, which occurred when the virus was inoculated shortly before or after a primary immunization, persisted in subsequent secondary responses. However, infection concomitant to secondary antibody responses did not affect their isotypic distribution. These observations suggest that the virus can durably modify unrelated T cell responses that are initiated at the time of infection, which could have implications in the pathogenesis of autoimmune reactions.
authors.affiliation: Unit of Experimental Medicine, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: J P
authors.initials: JP
authors.lastname: Coutelier
authors.forename: J T
authors.initials: JT
authors.lastname: van der Logt
authors.forename: F W
authors.initials: FW
authors.lastname: Heessen
mesh_terms: D000818:Animals; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000276:immunology*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis*; D051379:Mice; D006517:Murine hepatitis virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes