[Plant alkaloid from Ammopiptantus mongolia--an inhibitor of nitrogen oxide synthesis in animals].
A decrease of the formation in the mouse liver of nitrogen oxide incorporated into ferrum mononitrozyl complexes (FMNC) with diethyldithiocarbamate (DETC) recorded by ESR method was discovered. This decrease was induced by one of the alkaloids isolated from Ammopiptantus mongolica which grows in the Gobi desert. This effect seems to be due to the antioxidant properties of the alkaloid under study. Alkaloid lessened the formation of FMNC with DETC both in the control animals and in those treated with lipopolysaccharide from E. coli initiating inflammation processes and intensification of NO synthesis. Proceeding from the data obtained it is suggested that free radicals reacting with the antioxidant affect NO formation by increasing the level of free calcium in the cell.
Burgedbazar
B
B
Institute of Biotechnology, Ac. Sci. Mongolian Peoples Republic.
Kubrina
L N
LN
Egorov
V Iu
VIu
Vanin
A F
AF
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004050:Ditiocarb / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D005290:Ferric Compounds / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D009609:Nitrous Oxide / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000470:Alkaloids; D000975:Antioxidants; D005290:Ferric Compounds; D004050:Ditiocarb; D009609:Nitrous Oxide
Rastitel'nyĭ alkaloid iz Ammopiptantus mongolia--ingibitor sinteza oksida azota v organizme zhivotnykh.