[Mechanochemical solid state reactions of natural products for medicinal use containing hydroxyanthraquinone derivatives].
In commercial powdered natural products for medicinal use containing various combined forms of hydroxyanthraquinone derivatives such as Sennae Folium, Cassiae Semen, Rhei Rhizoma and Aloe a considerable amount of stable free radicals (ca. 10(17)-10(18) spin/g) was found to be contained by use of electron spin resonance (ESR) spectral measurements. It was also found that the vibratory milling of such powders in a metallic vessel enhanced the ESR spectral intensities, demonstrating the occurrence of mechanoradical formation. Separate experiments also demonstrated that the vibratory milling of various kinds of powdered hydroxyanthraquinone derivatives mixed with calcium oxalate has produced the mechanoradicals effectively, but they decayed gradually on standing at room temperature. It was suggested, therefore, that the mechanoradicals formed in the above natural products are metal complexes of the corresponding semiquinone anion radicals induced by solid state one electron transfer mechanism from the active metal surface, part of which is further immobilized in polymeric fibers or the like in the plant tissues.
Kuzuya
M
M
Gifu Pharmaceutical University, Japan.
Sakata
H
H
Kondo
S
S
Noguchi
A
A
D000880:Anthraquinones / Q000032:analysis* / Q000737:chemistry; D002129:Calcium Oxalate; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D004579:Electron Transport; D008670:Metals; D011208:Powders
D000880:Anthraquinones; D004365:Drugs, Chinese Herbal; D008670:Metals; D011208:Powders; D002129:Calcium Oxalate