Molecular mechanisms of leukocyte activation by chemoattractants.
Chemoattractant receptors on leukocytes initiate migratory and cytotoxic activities via GTP-binding proteins. Recent cloning of cDNA encoding the formylpeptide receptor indicates it to be a member of the class of seven membrane spanning domain receptors which couple to G proteins. Leukocyte activation by chemoattractants requires sequential metabolic pathways involving phospholipase C then phospholipase D. Interestingly, the formylpeptide receptor physically associates with both a heterotrimeric G protein and a low molecular mass GTP-binding protein. These multiple GTP-binding proteins may regulate the function of chemoattractant receptors.
Snyderman
R
R
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
Didsbury
J
J
D000818:Animals; D002630:Chemotactic Factors / Q000494:pharmacology*; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D007975:Leukotriene B4 / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology
D002630:Chemotactic Factors; D010972:Platelet Activating Factor; D007975:Leukotriene B4; D009240:N-Formylmethionine Leucyl-Phenylalanine; D019204:GTP-Binding Proteins