[Isochromosome 17q as the sole alteration in 2 patients with a myelodysplastic syndrome and its relation to myeloperoxidase activity].
Two patients diagnosed of myelodysplastic syndrome with an isochromosome i (17q) as the only chromosomal alteration are presented. The MAC method (i.e., morphology, antibodies, chromosomes) was applied in the study of one of the patients, it being found that all the myeloperoxidase-positive cells carried the i (17q) anomaly. Such finding might suggest that those patients with i (17q) as the only chromosomal alteration could have specific clinical and cytological features.
Solé
F
F
Unidad de Hematología y Oncología, Hospital Central L'Aliança de Barcelona.
Pérez
A
A
Woessner
S
S
Olmedo
E
E
Florensa
L
L
Sans
J
J
D000368:Aged; D000369:Aged, 80 and over; D000753:Anemia, Refractory / Q000235:genetics* / Q000473:pathology; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics* / Q000473:pathology; D015415:Biomarkers; D001853:Bone Marrow / Q000201:enzymology / Q000473:pathology; D002869:Chromosome Aberrations; D002886:Chromosomes, Human, Pair 17 / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009195:Peroxidase / Q000032:analysis*
D015415:Biomarkers; D009195:Peroxidase
Isocromosoma 17q como única alteración en dos pacientes con un síndrome mielodisplásico y su relación con la actividad mieloperoxidásica.