Aleatory clinical study comparing otilonium bromide with a fiber-rich diet in the treatment of irritable bowel syndrome.
We studied 114 patients affected by irritable bowel syndrome (IBS) (group A = 53 patients, group B = 61). Group A received diet with high content of roughage (20 g of fibers) and 10 g of bran, group B received otilonium bromide (OB) 40mg tid and normal diet (10-15 g of fibers). Abdominal pain, abdominal distension, bowel movements were evaluated before treatment (T0) at the end (T24) and after 12 months (T12). In group B otilonium bromide induced a significant improvement (p less than 0.01) of abdominal pain and distension when comparing T0 with T24. In group A diet produced an improvement, albeit not significant, of the aforementioned parameters at T24. On the basis of our data OB seems to be more effective than a high-fiber diet in the treatment of IBS.
Villagrasa
M
M
Gastroenterology Unit, Germans Trias i Pujol Hospital Badalona, Barcelona, Spain.
Boix
J
J
Humbert
P
P
Quer
J C
JC
D015746:Abdominal Pain / Q000628:therapy; D000328:Adult; D003109:Colonic Diseases, Functional / Q000628:therapy*; D004043:Dietary Fiber / Q000627:therapeutic use*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010276:Parasympatholytics / Q000627:therapeutic use*; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D013997:Time Factors
D004043:Dietary Fiber; D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; C013934:octylonium