title: Phenotypic and functional studies of human peripheral blood lymphocytes engrafted in scid mice.
abstract: CB.17 mice homozygous for the scid defect have been used as recipients of peripheral blood lymphocytes (PBL) from normal humans and from patients suffering from common variable immunodeficiency (CVI) types A and B. Following intra-peritoneal injection of PBL, such mice become chimeric with human cells, as evidenced by the presence in their serum of human immunoglobulins, which persist for a number of months. Under these conditions, B cells from CVI patients are also triggered to produce immunoglobulin. In contrast, T cells in the inocula, although they persist for 1 or 2 months in the peritoneal cavity, do not appear to function normally in antigen-specific responses and they do not recirculate in the recipient mice.
authors.affiliation: Transplantation Biology Section, Clinical Research Centre, Harrow, Middlesex, U.K.
authors.forename: E
authors.initials: E
authors.lastname: Simpson
authors.forename: J
authors.initials: J
authors.lastname: Farrant
authors.forename: P
authors.initials: P
authors.lastname: Chandler
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002472:Cell Transformation, Viral / Q000276:immunology; D002678:Chimera; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000473:pathology; D016130:Immunophenotyping; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D016513:Mice, SCID; D013997:Time Factors; D014183:Transplantation, Heterologous / Q000276:immunology*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M