title: A new cyclitol derivative influences inositol metabolism in Neurospora crassa.
abstract: Cyclitol derivatives have been synthesized and screened for growth inhibitory effect upon prokaryotic and eukaryotic organisms. One derivative, (2S,3R,5R)-3-azido-2-benzoyloxy-5-hydroxycyclohexanone, was studied in detail: it has no effect upon bacteria, but it is inhibitory to Neurospora crassa. In Neurospora crassa it increased the amount of myo-inositol-1-phosphate synthase and inhibited the activity of myo-inositol-monophosphatase. The enhanced synthesis of myo-inositol-1-phosphate synthase was the consequence of lowering the intracellular inositol concentration. Li+ treatment of Neurospora crassa has effects similar to those of P.I.-658.
authors.affiliation: Department of Biology, University Medical School, Debrecen, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Szabó
authors.forename: M
authors.initials: M
authors.lastname: Schablik
authors.forename: A
authors.initials: A
authors.lastname: Kiss
authors.forename: C
authors.initials: C
authors.lastname: Koncz
authors.forename: R
authors.initials: R
authors.lastname: Bognár
authors.forename: I
authors.initials: I
authors.lastname: Pelyvás
authors.forename: F
authors.initials: F
authors.lastname: Sztaricskai
mesh_terms: D002455:Cell Division / Q000187:drug effects; D003512:Cyclohexanones / Q000494:pharmacology*; D007294:Inositol / Q000378:metabolism*; D008094:Lithium / Q000494:pharmacology; D007296:Myo-Inositol-1-Phosphate Synthase / Q000378:metabolism; D009492:Neurospora crassa / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors
chemical_list: D003512:Cyclohexanones; D007294:Inositol; C067895:MI 658; D008094:Lithium; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase; D007296:Myo-Inositol-1-Phosphate Synthase