Inhibitory effects of 3-nitro-2,4,6-trihydroxybenzamides on Epstein-Barr virus early antigen induction.
Inhibitory effects of a series of 3-nitro-2,4,6-trihydroxybenzamides on Epstein-Barr virus early antigen (EBV-EA) induction were examined using Raji cells. Some of the tested compounds showed highly inhibitory activity, the N-octyl amide derivative being the most active among them. These results suggest the possibility that 3-nitro-2,4,6-trihydroxybenzamides might be listed as novel inhibitors of tumor promotion.
Honda
I
I
Life Science Research Laboratory, Japan Tobacco Inc., Yokohama.
Tokuda
H
H
Kozuka
M
M
Yoneyama
K
K
Nishino
H
H
Iwashima
A
A
Shibagaki
M
M
Noma
M
M
Takahashi
N
N
Yoshida
S
S
D000956:Antigens, Viral / Q000096:biosynthesis*; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000276:immunology; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D010696:Phloroglucinol