EndoCyte, an interactive computer program for quantitative analysis of receptor-mediated endocytosis.
We present EndoCyte, a user friendly interactive program for quantitative analysis of receptor-mediated endocytosis. The data, comprised of time-dependent concentrations of the ligand at the cell surface and the ligand internalized by cells, are analyzed by the application of a set of nested mathematical models of endocytosis. EndoCyte reduces data to parameters conventional in description of receptor-mediated endocytosis and a parameter which describes the non-linear effects. The performance of EndoCyte is documented by the analysis of applications to synthetic data.
Zelić
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A
Division of Developmental Oncology Research, Mayo Clinic, Rochester, MN 55905.
Bajzer
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Z
Vuk-Pavlović
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S
D003198:Computer Simulation; D001330:Electronic Data Processing / Q000295:instrumentation / Q000379:methods / Q000592:standards*; D004705:Endocytosis / Q000187:drug effects* / Q000502:physiology; D005069:Evaluation Studies as Topic; D006801:Humans; D008024:Ligands; D012986:Software Validation; D014584:User-Computer Interface
D008024:Ligands