title: High dose anticholinergic therapy (biperiden) in dystonia.
abstract: We studied the effect of biperiden in the treatment of dystonia in six patients aged 15-30 years. Five patients had generalized and one patient had segmental dystonia. Biperiden was started at a dose of 2 mg/day and was gradually increased to 40 mg/day in a few weeks. All patients had clinically significant response in varying degrees after a mean follow up of 1.9 years. Three patients showed considerable or dramatic benefit. The 40 mg/day was generally well tolerated. High dose anticholinergic therapy is effective in the management of torsion dystonia.
authors.affiliation: Department of Neurology, Hacettepe University, School of Medicine, Ankara, Turkey.
authors.forename: N S
authors.initials: NS
authors.lastname: Oztekin
authors.forename: S S
authors.initials: SS
authors.lastname: Saygi
authors.forename: T
authors.initials: T
authors.lastname: Dalkara
authors.forename: I
authors.initials: I
authors.lastname: Senses
authors.forename: T
authors.initials: T
authors.lastname: Zileli
mesh_terms: D000293:Adolescent; D000328:Adult; D001712:Biperiden / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D001712:Biperiden