Blockade of neurotransmitter-activated K+ conductance by QX-314 in the rat hippocampus.
Intracellular injection of QX-314 blocked the ability of baclofen and 5-carboxyamidotryptamine to hyperpolarize cells in the rat hippocampus. This effect was not associated with a reduction in the effects of norepinephrine on these cells nor a blockade of the potassium channels underlying the calcium-dependent afterhyperpolarization responsible or significant changes in membrane potential. These results suggest that QX-314 is an effective blocker of G-protein-gated potassium channels in this region.
Andrade
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Department of Pharmacological and Physiological Sciences, St. Louis University School of Medicine, MO 63104.
D000818:Animals; D001418:Baclofen / Q000037:antagonists & inhibitors*; D002118:Calcium; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D011963:Receptors, GABA-A / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology
D015221:Potassium Channels; D011963:Receptors, GABA-A; D011985:Receptors, Serotonin; C012647:QX-314; D012701:Serotonin; C047087:5-carboxamidotryptamine; D008012:Lidocaine; D001418:Baclofen; D002118:Calcium; D009638:Norepinephrine