title: Breast conserving surgery in the management of in situ breast carcinoma.
abstract: In a retrospective review of 73 patients with in situ breast carcinoma seen in the Combined Breast Clinic at the Royal Marsden and St. George's Hospitals between 1969 and 1988, 20 (27%) were found to have in situ lobular and 53 (73%) in situ intraduct carcinoma. Of 19 patients with in situ lobular carcinoma treated by breast conserving surgery alone there were three (16%) recurrences of in situ lobular carcinoma and one (5%) of infiltrating carcinoma after a mean follow-up period of 65.8 months. Of 53 patients with in situ intraduct carcinoma, 37 were treated by breast conserving surgery alone and in this group there were 14 (38%) recurrences, of which seven (19%) were in situ intraduct and seven (19%) were infiltrating carcinoma, after a mean follow-up of 96.5 months. Following successful salvage there were no breast cancer related deaths in either group.
authors.affiliation: Breast Research Unit, St. George's Hospital, Tooting, London, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Graham
authors.forename: S
authors.initials: S
authors.lastname: Lakhani
authors.forename: J C
authors.initials: JC
authors.lastname: Gazet
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D002277:Carcinoma / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery / Q000628:therapy; D012189:Retrospective Studies; D013514:Surgical Procedures, Operative / Q000379:methods