title: Metabolic effects of high-carbohydrate, high-fiber diets for insulin-dependent diabetic individuals.
abstract: The metabolic effects of high-carbohydrate (70%), high-fiber (70 g) (HCHF) and low-carbohydrate (39%), low-fiber (10 g) (LCLF) diets were examined for 10 subjects with insulin-dependent diabetes mellitus (IDDM). After a 1-wk control period subjects on a metabolic ward were randomly allocated to HCHF or LCLF diets for 4 wk. After a 6-wk washout period subjects re-entered the metabolic ward for 4 wk on the alternate diet. Artificial-pancreas studies were performed on each diet for measurement of insulin requirements. Compared with the LCLF diet, the HCHF diet reduced basal insulin requirements (P less than 0.025), increased carbohydrate disposed of per unit insulin (P less than 0.0008), and lowered total (P less than 0.0004) and high-density-lipoprotein cholesterol (P less than 0.0013). Glycemic control and other lipid fractions did not differ significantly. These results suggest that in IDDM patients, HCHF diets enhance peripheral glucose disposal, decrease basal insulin requirements, and lower total cholesterol without altering glycemic control or triglycerides.
authors.affiliation: Endocrine-Metabolic Section, VA Medical Center, Lexington, KY 40511.
authors.forename: J W
authors.initials: JW
authors.lastname: Anderson
authors.forename: J A
authors.initials: JA
authors.lastname: Zeigler
authors.forename: D A
authors.initials: DA
authors.lastname: Deakins
authors.forename: T L
authors.initials: TL
authors.lastname: Floore
authors.forename: D W
authors.initials: DW
authors.lastname: Dillon
authors.forename: C L
authors.initials: CL
authors.lastname: Wood
authors.forename: P R
authors.initials: PR
authors.lastname: Oeltgen
authors.forename: R J
authors.initials: RJ
authors.lastname: Whitley
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004043:Dietary Fiber / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D007328:Insulin; D002784:Cholesterol