Human herpesvirus-6 infection in bone marrow transplantation.
Twenty-five pediatric patients who received bone marrow transplantation (BMT) were studied prospectively to determine the relationship between BMT and human herpesvirus-6 (HHV-6) infection by the virus isolation from peripheral blood and/or bone marrow and by determining neutralizing antibodies to HHV-6 during the 2 months following BMT. All of the 25 donors and the recipients were immune to HHV-6 at the time of BMT and the virus was not isolated from them. HHV-6 was isolated from peripheral blood and/or bone marrow mononuclear cells in ten (40%) of the 25 recipients between day 14 and day 22 of BMT, but not from any other day. Two additional recipients showed a significant increase in the antibody titer. Thus, infection with HHV-6 was confirmed in 12 (48%) of the 25 recipients. Four of the 12 developed skin rashes; three of these four had a febrile episode when the virus was isolated, whereas none of the remaining 13 developed the skin rash. These results suggest a frequent infection with HHV-6 only a few weeks after BMT and a close association between the infection with the virus and the development of skin rashes.
Yoshikawa
T
T
Department of Pediatrics, Fujita Health University School of Medicine, Aichi, Japan.
Suga
S
S
Asano
Y
Y
Nakashima
T
T
Yazaki
T
T
Sobue
R
R
Hirano
M
M
Fukuda
M
M
Kojima
S
S
Matsuyama
T
T
D000293:Adolescent; D000914:Antibodies, Viral / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000382:microbiology; D006566:Herpesviridae Infections / Q000209:etiology* / Q000276:immunology; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000276:immunology / Q000382:microbiology / Q000601:surgery; D008297:Male; D012874:Skin Diseases, Infectious / Q000382:microbiology
D000914:Antibodies, Viral