title: [The action of an alkylating analog of hexadecamethonium on neuromuscular transmission in the frog].
abstract: The treatment of m. cutaneus pectoris-n. pectoralis preparations with 0.5 microM of alkylating derivate of hexadecamethonium, hexadecamethylene-bis-methylchloroethylamine, led to irreversible decrease of the amplitude of EPPs. The decrease was shown to be of a postsynaptic nature. After pretreatment of the neuromuscular preparations with alkylating derivate the effects of cholinesterase inhibitors were strongly diminished.
authors.forename: V M
authors.initials: VM
authors.lastname: Grigor'ev
authors.forename: V A
authors.initials: VA
authors.lastname: Snetkov
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D003650:Decamethonium Compounds / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008839:Microelectrodes; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D011896:Rana temporaria; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
chemical_list: D000477:Alkylating Agents; D002800:Cholinesterase Inhibitors; D003650:Decamethonium Compounds; D009588:Nitrogen Mustard Compounds; C075344:N,N'-bis(2-chloroethyl)-N,N'-dimethyl-1,16-hexadecanediamine
vernacular_title: Deĭstvie alkiliruiushchego analoga geksadekametoniia na nervno-myshechnuiu peredachu liagushki.