Transcriptional regulation by cAMP.
Cyclic AMP regulates a myriad of cellular processes through the cAMP-dependent protein kinase A. In many cases, activation of protein kinase A leads to altered patterns of gene transcription. Identification of the cAMP-response-element-binding-protein as a major nuclear substrate for protein kinase A accounts for many recent advances in understanding the signal transduction pathway. This review will focus on the role of cAMP-response-element-binding protein in coupling protein kinase A to the transcriptional machinery and the mechanisms that control cAMP signalling during mammalian development.
Lee
K A
KA
Imperial Cancer Research Fund, Potters Bar, Hertfordshire, UK.
D000818:Animals; D002454:Cell Differentiation; D000242:Cyclic AMP / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D012045:Regulatory Sequences, Nucleic Acid; D015398:Signal Transduction; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D000242:Cyclic AMP