Histidine residue is crucial for the binding of ligands to the benzodiazepine site except Ro15-4513.
Binkley
P
P
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
Ticku
M K
MK
D000818:Animals; D001386:Azides / Q000378:metabolism*; D001569:Benzodiazepines / Q000378:metabolism*; D001665:Binding Sites; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D004047:Diethyl Pyrocarbonate / Q000494:pharmacology; D005445:Flunitrazepam / Q000378:metabolism; D006639:Histidine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*
D001386:Azides; D011963:Receptors, GABA-A; D001569:Benzodiazepines; D006639:Histidine; D005445:Flunitrazepam; C042957:Ro 15-4513; D004047:Diethyl Pyrocarbonate