[Membranoreceptor disorders in the pathogenesis of bronchial asthma].
The purpose of the work was to study some characteristic features of the membranoreceptor complex in patients suffering from atopic bronchial asthma (BA) and infection-dependent BA. That was done with the aid of the erythrocytic model (phytohemagglutinin /PHA/ reception, electrophysical analysis of the membranous properties). Electrophoretic mobility (EPM) of red blood cells and red blood cell sedimentation under the action of PHA were determined. The data obtained indicate that in patients with infection-dependent BA, the membranoreceptor complex is characterized by a decrease of EPM of red blood cells, inhibition of red blood cell sedimentation in the presence of PHA. The results of studying the membranoreceptor complex in BA patients are summarized as are the marker characteristics of atopic and infection-dependent BA, reflecting pathology of reception, glycocalyx, and lipid matrix.
Zhikharev
S S
SS
Mineev
V N
VN
Lukashevskaia
N N
NN
D001249:Asthma / Q000097:blood / Q000209:etiology*; D001799:Blood Sedimentation; D004586:Electrophoresis; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007239:Infections / Q000150:complications; D010835:Phytohemagglutinins / Q000494:pharmacology; D011956:Receptors, Cell Surface / Q000097:blood*
D010835:Phytohemagglutinins; D011956:Receptors, Cell Surface
Membranoretseptornye narusheniia v patogeneze bronkhial'noĭ astmy.