Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.
We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Moreover, RAR-alpha 2 and RAR-beta 2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha 2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.
Leroy
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P
Laboratoire de Génétique Moléculaire des Eucaryotes, Unité 184 de Biologie Moléculaire et de Génie Génétique, Institut National de la Santé et de la Recherche Médicale, Strasbourg, France.
Nakshatri
H
H
Chambon
P
P
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002460:Cell Line; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005796:Genes; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense; D011401:Promoter Regions, Genetic; D018168:Receptors, Retinoic Acid; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D014212:Tretinoin / Q000378:metabolism*
D002352:Carrier Proteins; D016376:Oligonucleotides, Antisense; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D004247:DNA