title: Recurrent mucocutaneous lymphocytic infiltration possibly associated with Epstein-Barr virus infection.
abstract: A 32-year-old man had a history of recurrent but self-healing necrotizing nodules on the face and oral mucosa. Histologically the lesion was composed of necrotizing foci surrounded with dense CD8+ T lymphocytic infiltration in the dermis. Laboratory examination showed marked blood CD8+ T lymphocytosis with a reversed ratio of CD4+/CD8+ of 0.11. Except for a very high titer of antibodies against Epstein-Barr-virus-associated antigens, no signs of infection were observed.
authors.affiliation: Department of Dermatology, Osaka University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Tei
authors.forename: T
authors.initials: T
authors.lastname: Yamamura
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Negoro
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D001706:Biopsy; D016516:CD4-CD8 Ratio; D016827:CD8 Antigens; D005148:Facial Dermatoses / Q000097:blood / Q000209:etiology* / Q000473:pathology; D006566:Herpesviridae Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D004854:Herpesvirus 4, Human; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D009059:Mouth Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D009336:Necrosis; D010784:Photomicrography; D012008:Recurrence; D013601:T-Lymphocytes / Q000737:chemistry
chemical_list: D016827:CD8 Antigens; D007070:Immunoglobulin A; D007075:Immunoglobulin M