title: Immunopathology of Marek's disease in quails: presence of antinuclear antibody and immune complex.
abstract: Antinuclear antibody (ANA), a marker for autoimmune reactions, was detected in the sera of quails with Marek's disease (MD). The autoantibody was detected 3 weeks after infection in quails infected with chicken Marek's disease virus and 4 weeks after infection in quails infected with quail Marek's disease virus. The ANA titers were low and ranged from 10 to 40. A speckled type of nuclear fluorescence was the characteristic staining feature. In addition to the presence of ANA, immune complexes (IC) were also detected in the kidney glomeruli of quail infected with Marek's disease virus. Initially about 25-30% of the glomeruli in the kidneys of infected quails had IC deposits. In subsequent periods, the amount of IC deposit and the number of glomeruli showing IC also increased considerably. The findings of the present study suggested autoimmunity may play a pathogenic role in MD.
authors.affiliation: Division of Avian Disease, Indian Veterinary Research Institute, Izatnagar.
authors.forename: L
authors.initials: L
authors.lastname: Kaul
authors.forename: H K
authors.initials: HK
authors.lastname: Pradhan
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis*; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001323:Autoantibodies / Q000276:immunology; D001715:Bird Diseases / Q000276:immunology* / Q000473:pathology; D005455:Fluorescent Antibody Technique; D008381:Herpesvirus 2, Gallid / Q000276:immunology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008380:Marek Disease / Q000276:immunology* / Q000473:pathology; D011784:Quail / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D001323:Autoantibodies