title: High voltage activated calcium channels: molecular composition and function.
abstract: Voltage-activated calcium channels comprise a group of similar yet distinct proteins or protein complexes that differ in electrophysiological properties, modulation by phosphorylation and GTP-binding proteins and in their relative sensitivity to organic calcium channel blockers. Cloning of the cDNA of L-type calcium channels from skeletal muscle, heart and smooth muscle opens the way to understanding the molecular basis of channel function and regulation and provides means of studying calcium channels in other tissues.
authors.affiliation: Medizinische Biochemie, Universität des Saarlandes, Homburg, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Flockerzi
authors.forename: E
authors.initials: E
authors.lastname: Bosse
authors.forename: M
authors.initials: M
authors.lastname: Biel
authors.forename: R
authors.initials: R
authors.lastname: Hullin
authors.forename: F
authors.initials: F
authors.lastname: Hofmann
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000378:metabolism; D015220:Calcium Channels / Q000737:chemistry* / Q000502:physiology*; D009130:Muscle, Smooth / Q000737:chemistry; D009132:Muscles / Q000737:chemistry; D009206:Myocardium / Q000737:chemistry; D011817:Rabbits; D011978:Receptors, Nicotinic / Q000737:chemistry
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D011978:Receptors, Nicotinic