BK virus and JC virus shed during pregnancy have predominantly archetypal regulatory regions.
Twenty-three BK virus and JC virus DNA samples obtained from urine of pregnant women had almost exclusively archetypal transcriptional control regions. Rearrangements characteristic of laboratory strains are apparently not required for reactivation in humans. Unexpectedly, alignment shows that many elements identified previously in the BK virus enhancer are conserved in the JC virus archetype.
Markowitz
R B
RB
Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.
Eaton
B A
BA
Kubik
M F
MF
Latorra
D
D
McGregor
J A
JA
Dynan
W S
WS
D001739:BK Virus / Q000235:genetics*; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D004742:Enhancer Elements, Genetic; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007577:JC Virus / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology* / Q000652:urine; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic; D014412:Tumor Virus Infections / Q000382:microbiology* / Q000652:urine; D014556:Urine / Q000382:microbiology
D004279:DNA, Viral