Synthesis and pharmacological investigation of new N-dimethylpyridyl and N-chloropyridyl substituted arylsuccinimides.
In the reaction of alpha-phenyl-, alpha-p-chlorophenyl-, alpha-m-chlorophenyl-, alpha-p-bromophenyl and alpha-m-bromophenyl succinic acids with various aminopyridines, N-(dimethylpyridine)-alpha- arylsuccinimides and N-(chloropyridine)-alpha-arylsuccinimides were obtained. The above compounds tested for their CNS activity did not show an anticonvulsant activity.
Zejc
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Department of Pharmaceutical Chemistry, School of Medicine, Kraków, Poland.
Obniska
J
J
Jakowicz
I
I
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000927:Anticonvulsants; D011725:Pyridines; D013388:Succinimides