Mechanism of action of newly developed vitamin D analogue.
26,27-F6-1,25(OH)2D3 has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo, instead of almost equal binding to 1,25(OH)2D3 receptor and comparatively short serum half-life. To date, the mechanism of higher action is not known, but using these analogues as a mirror we might be able to elucidate the mechanism of action or the metabolism of the kidney hormone, 1,25(OH)2D3.
Okamoto
S
S
First Department of Medicine, Nagasaki University, Japan.
Ejima
E
E
Kiriyama
T
T
Izumi
M
M
Komori
A
A
Suzuki
H
H
Katsumata
T
T
Nagata
A
A
D000818:Animals; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D006801:Humans; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000378:metabolism; D005466:Fluorocarbons
D002117:Calcitriol; D002118:Calcium; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; C040488:26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3; D005466:Fluorocarbons