The importance of the specific Z-DNA structure and polyamines in carcinogenesis: fact or fiction.
In this work some aspects of carcinogenesis are given. The importance of the emergence of Z or H DNA structure in the gene, or in the flanking gene sequences for the gene deletion and unusual gene recombination, is discussed. Some considerations on the role of selective pressure (of polyamines, of Mg2+, of the various levels of topoisomerase II, and of ATP) in the process of oncogene amplification, are given too.
Juranic
Z
Z
Institute for Oncology and Radiology, Yugoslavia.
Kidric
M
M
Tomin
R
R
Juranić
I
I
Spuzić
I
I
Petrović
J
J
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D005784:Gene Amplification; D006801:Humans; D008274:Magnesium / Q000378:metabolism; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D011073:Polyamines / Q000378:metabolism*
D011073:Polyamines; D004247:DNA; D004250:DNA Topoisomerases, Type II; D008274:Magnesium