Toxic megacolon associated with anticancer chemotherapy.
The majority of gastrointestinal side effects associated with anticancer chemotherapy are relatively mild and self-limiting and can be managed empirically. However, severe side effects, such as necrotizing enterocolitis and ischemic colitis, sometimes do occur after chemotherapy. The authors present a case of toxic megacolon associated with anticancer chemotherapy. This is a relatively uncommon but potentially lethal complication of ulcerative colitis.
de Gara
C J
CJ
Department of Surgery, Henderson General Hospital, Hamilton, Ont.
Gagic
N
N
Arnold
A
A
Seaton
T
T
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D015412:Mastectomy, Segmental; D008532:Megacolon, Toxic / Q000139:chemically induced* / Q000601:surgery; D011183:Postoperative Complications