Genetic difference in sensitivity to beta-carboline: evidence for the involvement of brain benzodiazepine receptors.
The convulsive effects of methyl beta-carboline-3-carboxylate (beta-CCM), a benzodiazepine receptor ligand, are different in two inbred strains of mice: BALB/cBy mice are more sensitive to beta-CCM than C57BL/6J mice. In the present article, we report the effects of [3H]flunitrazepam binding in these two strains, which suggest a possible explanation of the differences in their sensitivity to beta-CCM by the involvement of brain benzodiazepine receptors.
Chapouthier
G
G
Génétique, Neurogénétique et Comportement, U.R.A. C.N.R.S. 1294, Université Paris V, France.
Bondoux
D
D
Martin
B
B
Desforges
C
C
Launay
J M
JM
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002243:Carbolines / Q000494:pharmacology*; D002998:Clonazepam / Q000494:pharmacology; D003292:Convulsants / Q000494:pharmacology*; D005445:Flunitrazepam / Q000378:metabolism*; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism*; D012640:Seizures / Q000503:physiopathology; D013045:Species Specificity; D013331:Strychnine / Q000633:toxicity
D002243:Carbolines; D003292:Convulsants; D011963:Receptors, GABA-A; C026072:1-methyl-beta-carboline-3-carboxylic acid; D002998:Clonazepam; D005445:Flunitrazepam; D013331:Strychnine; C036150:beta-carboline-3-carboxylic acid methyl ester