MyoD1 protein expression in alveolar soft part sarcoma as confirmatory evidence of its skeletal muscle nature.
A typical case of alveolar soft part sarcoma was found to express in a strong and widespread fashion the marker MyoD1 protein. This nuclear phosphoprotein is the product of a regulatory gene that controls the commitment of a cell to myogenic lineage; it therefore provides strong and perhaps definitive evidence in support of the skeletal muscle nature of this enigmatic neoplasm.
Rosai
J
J
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.
Dias
P
P
Parham
D M
DM
Shapiro
D N
DN
Houghton
P
P
D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D005455:Fluorescent Antibody Technique; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics / Q000378:metabolism*; D009132:Muscles / Q000473:pathology*; D017570:MyoD Protein; D012509:Sarcoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D009124:Muscle Proteins; D017570:MyoD Protein