Review article: the histamine H3-receptor: a novel prejunctional receptor regulating gastrointestinal function.
This review examines the evidence for the existence in the gastrointestinal tract of a new subtype (H3) of histamine receptors, previously described in the central nervous system. Study of these receptors is facilitated by the availability of the highly selective agonist (R) alpha-methylhistamine and the selective antagonist, thioperamide. H3-receptors seem to exert negative control on gastric acid secretion evoked by indirect cholinergic stimuli: their localization is unclear but it seems to be outside the parietal cell. H3-receptors also seem to be located on cholinergic and non-adrenergic non-cholinergic (NANC) neurones of the myenteric plexus, where they negatively control the release of neurotransmitters.
Bertaccini
G
G
Institute of Pharmacology, University of Parma, Italy.
Coruzzi
G
G
Poli
E
E
D000818:Animals; D004064:Digestive System / Q000648:ultrastructure*; D004068:Digestive System Physiological Phenomena; D005744:Gastric Acid / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D009469:Neuromuscular Junction / Q000502:physiology / Q000648:ultrastructure; D011968:Receptors, Histamine / Q000502:physiology*; D018100:Receptors, Histamine H3
D011968:Receptors, Histamine; D018100:Receptors, Histamine H3