The influence of H1-, H2- and H3-receptors on the spontaneous and ConA induced histamine release from human adenoidal mast cells.
The effects of the H3-agonist R-alpha-methylhistamine (R-alpha-MeHA) and the H3-antagonist thioperamide on the spontaneous and concanavalin A (ConA) induced histamine release from human mast cells were tested and compared with the effect of some H1- and H2-receptor active substances. R-alpha-MeHA (10(-9)-10(-7) M) exerted no effect on histamine release whereas thioperamide increased the spontaneous release at 10(-6)-10(-4) M but inhibited the ConA induced release in a narrow concentration range (10(-6)-10(-5) M). This enhancement might be taken as an indication of the existence of H3-receptor dependent autoregulation although presently other mechanism cannot be excluded.
Bent
S
S
Institut für Pharmakologie und Toxikologie, Medizinische Fakultät der RWTH Aachen.
Fehling
U
U
Braam
U
U
Schunack
W
W
Schmutzler
W
W
D000234:Adenoids / Q000166:cytology*; D002927:Cimetidine / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology; D006633:Histamine Antagonists; D006801:Humans; D006919:Hydroxyzine / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D017446:Impromidine; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D008468:Meclizine / Q000494:pharmacology; D008761:Methylhistamines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology*; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000502:physiology; D018100:Receptors, Histamine H3
D006146:Guanidines; D006633:Histamine Antagonists; D007093:Imidazoles; D008761:Methylhistamines; D010880:Piperidines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D018100:Receptors, Histamine H3; D003208:Concanavalin A; D006919:Hydroxyzine; D008468:Meclizine; C069357:alpha-methylhistamine; D002927:Cimetidine; D017446:Impromidine; C052075:thioperamide