Serum paraoxonase polymorphism in three populations of southeast Asia.
Serum paraoxonase hydrolyzes paraoxon, the principal metabolite of the insecticide parathion. Serum paraoxonase is polymorphic and controlled by two codominant alleles - PON*A and PON*B representing low and high activity, respectively. Three populations of southeast Asia comprising 194 Chinese, 159 Filipinos and 73 Dravidian Indians were investigated for serum paraoxonase polymorphism. The frequency of PON*B was found to be 0.14 in the Chinese, 0.04 in the Filipinos and 0.18 in Dravidian Indians. The distribution of the PON phenotypes was at Hardy-Weinberg equilibrium in all the three populations studied.
Roy
A C
AC
Department of Obstetrics and Gynaecology, National University of Singapore.
Saha
N
N
Tay
J S
JS
Ratnam
S S
SS
D043303:Aryldialkylphosphatase; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010744:Phosphoric Monoester Hydrolases / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012846:Singapore / Q000208:ethnology
D010744:Phosphoric Monoester Hydrolases; D043303:Aryldialkylphosphatase