title: The mechanism of action of the anti-herpes virus compound 2,3-dimethyl-6(2-dimethylaminoethyl)-6H-indolo-(2,3-b)quinoxaline.
abstract: The compound 2,3-dimethyl-6(2-dimethylaminoethyl)6H-indolo-(2,3-b)quinoxaline (B-220) has been shown to exhibit potent antiviral activity against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV) and cytomegalovirus (CMV). The mechanism of antiviral action of B-220 against HSV-1 has been studied; from the results it appears that B-220 binds by intercalation into the DNA helix and then disturbs steps that are vital for viral uncoating.
authors.affiliation: Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Harmenberg
authors.forename: A
authors.initials: A
authors.lastname: Akesson-Johansson
authors.forename: A
authors.initials: A
authors.lastname: Gräslund
authors.forename: T
authors.initials: T
authors.lastname: Malmfors
authors.forename: J
authors.initials: J
authors.lastname: Bergman
authors.forename: B
authors.initials: B
authors.lastname: Wahren
authors.forename: S
authors.initials: S
authors.lastname: Akerfeldt
authors.forename: L
authors.initials: L
authors.lastname: Lundblad
authors.forename: S
authors.initials: S
authors.lastname: Cox
mesh_terms: D000327:Adsorption; D000998:Antiviral Agents / Q000378:metabolism / Q000494:pharmacology*; D002213:Capsid / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line; D002478:Cells, Cultured; D004279:DNA, Viral / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D011810:Quinoxalines / Q000378:metabolism / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects*; D013053:Spectrophotometry; D013696:Temperature
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D007211:Indoles; D011810:Quinoxalines; C060183:B 220