[Evaluation of the effectiveness of drug therapy of autonomic paroxysms in relation to the variability of cardiac rhythm].
A study was made of changes in the amplitude and percentile contribution of respiratory waves and slow waves of heart rhythm (SW1 with a period of 8-14 s and SW2 with a period of 14-60 s) in 13 patients with panic attacks (PA) in the lying position after the 3-day monotherapy with the beta-blocker propranolol, alpha-blocker phentolamine and diazepam. Propranolol normalized baroreflex regulation of arterial pressure and raised SW1. Phentolamine, producing an analogous effect, enhanced sympathoadrenal activation and the rate of PA, reducing RW. The amplitude of SW2 that correlated with emotional tension and anxiety fell only as a result of the administration of diazepam. The latter drug did not influence the baroreflex (via SW1) and vagal (via RW) mechanisms of regulation.
Khaspekova
N B
NB
Loseva
M M
MM
Kuterman
E M
EM
D000328:Adult; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology; D003975:Diazepam / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D010200:Panic / Q000187:drug effects* / Q000502:physiology; D010646:Phentolamine / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*
D011433:Propranolol; D003975:Diazepam; D010646:Phentolamine
Otsenka éffektivnosti lekarstvennoĭ terapii vegetativnykh paroksizmov po spektru variativnosti ritma serdtsa.