title: A transcortin-binding protein in the plasma membrane of human syncytiotrophoblast.
abstract: Using affinity chromatography on immobilized transcortin of 125I-labeled, cholate-solubilized plasma membranes of human syncytiotrophoblast, a transcortin-binding protein with a minimal Mr of about 20 kDa has been isolated. It was found to be a sialoglycoprotein with an isoelectric point at pH 4.4 (about 5.0 after the treatment with neuraminidase). We assume that this protein is a component of membrane recognition system for transcortin-steroid complexes.
authors.affiliation: Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, U.S.S.R.
authors.forename: S A
authors.initials: SA
authors.lastname: Krupenko
authors.forename: G V
authors.initials: GV
authors.lastname: Avvakumov
authors.forename: O A
authors.initials: OA
authors.lastname: Strel'chyonok
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D011232:Chemical Precipitation; D002846:Chromatography, Affinity; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007525:Isoelectric Focusing; D011956:Receptors, Cell Surface / Q000302:isolation & purification*; D011987:Receptors, Steroid / Q000302:isolation & purification*; D015843:Serpins; D014156:Transcortin / Q000378:metabolism*; D014238:Trichloroacetic Acid; D014327:Trophoblasts / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D011987:Receptors, Steroid; C534935:SERPINA6 protein, human; D015843:Serpins; D014238:Trichloroacetic Acid; D014156:Transcortin