title: Evaluation of the efficacy of a low-passage bovine rotavirus (strain WC3) vaccine in children in Central Africa.
abstract: The safety and efficacy of a WC3 rotavirus vaccine was evaluated in a double-blind placebo-controlled trial involving 472 children in Bangui (Central African Republic). Each child received two doses of either placebo (235 children) or vaccine (237 children) at a 1-month interval, the first dose being given at 3 months of age. During the follow-up survey 9 months after the first dose, 117 rotavirus diarrhoeas were observed, 59 in the placebo group, 58 in the vaccinated group. The only positive effect of the vaccine was a significantly higher proportion of mild rotavirus diarrhoeal episodes in the vaccinated group than in the placebo group. Of the children in the vaccinated group, 60% had a positive immune response to WC3 rotavirus when tested by plaque reduction seroneutralization.
authors.affiliation: Institut Pasteur, Bangui.
authors.forename: M C
authors.initials: MC
authors.lastname: Georges-Courbot
authors.forename: J
authors.initials: J
authors.lastname: Monges
authors.forename: M R
authors.initials: MR
authors.lastname: Siopathis
authors.forename: J B
authors.initials: JB
authors.lastname: Roungou
authors.forename: G
authors.initials: G
authors.lastname: Gresenguet
authors.forename: L
authors.initials: L
authors.lastname: Bellec
authors.forename: J C
authors.initials: JC
authors.lastname: Bouquety
authors.forename: C
authors.initials: C
authors.lastname: Lanckriet
authors.forename: M
authors.initials: M
authors.lastname: Cadoz
authors.forename: L
authors.initials: L
authors.lastname: Hessel
mesh_terms: D000350:Africa, Central / Q000453:epidemiology; D000818:Animals; D002417:Cattle; D015331:Cohort Studies; D003968:Diarrhea, Infantile / Q000453:epidemiology / Q000517:prevention & control; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000517:prevention & control*; D022243:Rotavirus Vaccines; D014765:Viral Vaccines / Q000009:adverse effects
chemical_list: D022243:Rotavirus Vaccines; D014765:Viral Vaccines; C058442:WC3 rotavirus vaccine