High dose anticholinergic therapy (biperiden) in dystonia.
We studied the effect of biperiden in the treatment of dystonia in six patients aged 15-30 years. Five patients had generalized and one patient had segmental dystonia. Biperiden was started at a dose of 2 mg/day and was gradually increased to 40 mg/day in a few weeks. All patients had clinically significant response in varying degrees after a mean follow up of 1.9 years. Three patients showed considerable or dramatic benefit. The 40 mg/day was generally well tolerated. High dose anticholinergic therapy is effective in the management of torsion dystonia.
Oztekin
N S
NS
Department of Neurology, Hacettepe University, School of Medicine, Ankara, Turkey.
Saygi
S S
SS
Dalkara
T
T
Senses
I
I
Zileli
T
T
D000293:Adolescent; D000328:Adult; D001712:Biperiden / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004421:Dystonia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male
D001712:Biperiden