Inhibition of rotavirus and enterovirus infections by tea extracts.
Epigallocatechin gallate from green tea and theaflavin digallate from black tea inhibited infections of cultured rhesus monkey kidney MA 104 cells with rotaviruses and enteroviruses. Their antiviral effects were maximally induced when directly added to virus, and their pre- and post-treatment of the cells produced much weak antiviral activity. Antiviral activity of the extracts therefore seems to be attributable to interference with virus adsorption.
Mukoyama
A
A
Department of Enteroviruses, National Institute of Health, Tokyo, Japan.
Ushijima
H
H
Nishimura
S
S
Koike
H
H
Toda
M
M
Hara
Y
Y
Shimamura
T
T
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D044946:Biflavonoids; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D002460:Cell Line; D004770:Enterovirus / Q000187:drug effects*; D012401:Rotavirus / Q000187:drug effects*; D013662:Tea / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D044946:Biflavonoids; D013662:Tea; C056068:theaflavin; D002392:Catechin; C045651:epigallocatechin gallate