title: Antibody to human retroviruses among drug users in three east coast American cities, 1972-1976.
abstract: Between 1972 and 1976, 585 persons attending methadone maintenance clinics at East Coast veterans hospitals were enrolled in a survey of hepatitis antibody prevalence. Sera were tested for human immunodeficiency virus (HIV) and human T lymphotropic virus (HTLV) using both HTLV-I and HTLV-II immunoblots. Clinical and death records were also reviewed. None of the sera had HIV antibodies (upper 95% confidence limit, 0.5%); however, 103 (18%) had reactivity to HTLV. The profile of reactivity suggested that these subjects had been exposed to HTLV-II rather than to HTLV-I. Prevalence was as high in the early 1970s as today and correlated with duration of drug use rather than age. Neither cancers, specific neurologic diseases, nor excess deaths from any cause (overall 14%) could be ascribed to seropositivity. Therefore, HTLV (probably HTLV-II) has been a common infection of drug users for many years but adverse outcomes following infection were not demonstrated.
authors.affiliation: Viral Epidemiology Section, National Cancer Institute, Bethesda, Maryland 20852.
authors.forename: R J
authors.initials: RJ
authors.lastname: Biggar
authors.forename: Z
authors.initials: Z
authors.lastname: Buskell-Bales
authors.forename: P N
authors.initials: PN
authors.lastname: Yakshe
authors.forename: D
authors.initials: D
authors.lastname: Caussy
authors.forename: G
authors.initials: G
authors.lastname: Gridley
authors.forename: L
authors.initials: L
authors.lastname: Seeff
mesh_terms: D000328:Adult; D015480:Deltaretrovirus Antibodies / Q000097:blood*; D006800:Deltaretrovirus Infections / Q000150:complications* / Q000453:epidemiology; D004219:District of Columbia / Q000453:epidemiology; D005260:Female; D005431:Florida / Q000453:epidemiology; D005500:Follow-Up Studies; D015481:HTLV-I Antibodies / Q000097:blood; D015482:HTLV-II Antibodies / Q000097:blood; D006556:Heroin Dependence / Q000150:complications; D006801:Humans; D015151:Immunoblotting; D008297:Male; D009515:New Jersey / Q000453:epidemiology; D015995:Prevalence; D012044:Regression Analysis; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D015480:Deltaretrovirus Antibodies; D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies