title: Non-Hodgkin's lymphomas in patients with human immunodeficiency virus infection. Presence of Epstein-Barr virus by in situ hybridization, clinical presentation, and follow-up.
abstract: The authors studied all patients with serologic evidence of human immunodeficiency virus (HIV) infection and malignant non-Hodgkin's lymphoma (NHL) that presented at a single hospital from 1982 to 1989. Sixteen patients were identified, all white homosexual men with a mean age of 38.2 years. Lymphoma was the initial presentation of HIV infection in 37.5%. Sixty-two percent of the cases had a high-grade NHL, 31% had intermediate-grade, and 6% (one patient) had a low-grade lymphoplasmacytoid lymphoma. Extranodal involvement was present in 43.7%, with the gastrointestinal tract and liver being the most common sites. Actuarial survival was increased by treatment with methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B). Colorimetric in situ hybridization identified Epstein-Barr virus (EBV) in nine of the 14 cases hybridized. A statistically significant association of EBV with diffuse small noncleaved type (i.e., Burkitt's-like) (six of six) compared with other morphologic types (three of eight) was found (P = 0.025).
authors.affiliation: Department of Pathology, University School of Medicine, Atlanta, Georgia.
authors.forename: J
authors.initials: J
authors.lastname: Guarner
authors.forename: C
authors.initials: C
authors.lastname: del Rio
authors.forename: D
authors.initials: D
authors.lastname: Carr
authors.forename: L E
authors.initials: LE
authors.lastname: Hendrix
authors.forename: J W
authors.initials: JW
authors.lastname: Eley
authors.forename: E R
authors.initials: ER
authors.lastname: Unger
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D015996:Survival Rate; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality