[The effect of sympathetic denervation on the structure, contractility and electrical activity of the smooth-muscle cells in the cat nictitating membrane].
The nucleus and soma of sympathetically denervated smooth muscle cells (SMCs) of the cat nictitating membrane were found to be enlarged. The number of free ribosomes was dramatically increased and a disintegration of microfilaments was found. The functional changes involved spontaneous or agonist-induced generation of APs. These findings suggest that the denervation destructed the adrenoreceptor control mechanisms of the excitable membrane's potential. The possibility of emergence of new Ca2+ channels in the denervated SMCs is discussed.
Akhmedzianov
R Kh
RKh
Chelyshev
Iu A
IuA
Nizamov
R S
RS
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002415:Cats; D015171:Ganglionectomy; D008854:Microscopy, Electron; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation* / Q000502:physiology / Q000648:ultrastructure; D009541:Nictitating Membrane / Q000187:drug effects / Q000294:innervation* / Q000502:physiology / Q000648:ultrastructure; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000502:physiology*
D011189:Potassium Chloride; D009638:Norepinephrine
Vliianie simpaticheskoĭ denervatsii na strukturu, sokratimost' i élektricheskuiu aktivnost' gladkomyshechnykh kletok migatel'noĭ pereponki koshki.