Evidence that genetic emphysema in tight-skin mice is not caused by neutrophil elastase.
Mutant tight-skin mice that had severe pulmonary emphysema were crossed with beige mice that contained neutrophils deficient in elastase activity. The resultant tight skin-beige cross mice were deficient in neutrophil elastase activity, yet they were still afflicted with the same degree of severe emphysema as the tight-skin mice. The results indicate that neutrophil elastase does not cause the emphysematous lesions found in tight-skin mice.
Starcher
B
B
Department of Biochemistry, University of Texas Health Center, Tyler 75710.
James
H
H
D000818:Animals; D004646:Emphysema / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D008168:Lung / Q000201:enzymology / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D009504:Neutrophils / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000502:physiology*; D009195:Peroxidase / Q000378:metabolism; D012868:Skin Abnormalities
D009195:Peroxidase; D010196:Pancreatic Elastase