[Some parameters of endocrine function in patients with hemophilia].
The hormonal status of 40 patients with hemophilia A and in 5 patients with hemophilia B was investigated by radioimmunoassay during exacerbation against a background of the hemorrhagic syndrome and in remission. A decrease in the plasma levels of cortisol, T3, insulin and high levels of ACTH and estradiol were observed in patients with a severe type hemophilia during exacerbation. Remission was characterized by an increase in the STH level and a decrease in the ACTH level. The severity of hemorrhagic manifestations was determined not only by a degree of a decrease in the level of blood factor VIII but also by a degree of a decrease in the levels of cortisol, T3 and insulin. Hormonal drugs (prednisolone, thyroidin and methyl androstenediol) were also included in multimodality therapy of hemophilia.
Dedov
I I
II
Germanov
V A
VA
Zakharova
N O
NO
D000293:Adolescent; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003131:Combined Modality Therapy; D004958:Estradiol / Q000097:blood; D006467:Hemophilia A / Q000097:blood* / Q000628:therapy; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012074:Remission Induction / Q000379:methods; D014284:Triiodothyronine / Q000097:blood
D006728:Hormones; D007328:Insulin; D014284:Triiodothyronine; D004958:Estradiol; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
Nekotorye pokazateli funktsii éndokrinnoĭ sistemy u bol'nykh gemofilieĭ.