Interaction of citrus juices with felodipine and nifedipine.
Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice. The mean felodipine bioavailability with grapefruit juice was 284 (range 164-469)% of that with water. The dehydrofelodipine/felodipine AUC ratio was lower, diastolic blood pressure lower, and heart rate higher with grapefruit juice than with water. Vasodilatation-related side-effects were more frequent. Orange juice had no such effects. Six healthy men took nifedipine 10 mg with water or grapefruit juice; the bioavailability with grapefruit juice was 134 (108-169)% of that with water.
Bailey
D G
DG
Department of Medicine, Victoria Hospital, University of Western Ontario, London, Canada.
Spence
J D
JD
Munoz
C
C
Arnold
J M
JM
D001682:Biological Availability; D001794:Blood Pressure / Q000187:drug effects; D002957:Citrus / Q000378:metabolism*; D004347:Drug Interactions; D005069:Evaluation Studies as Topic; D015736:Felodipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D009543:Nifedipine; D015736:Felodipine