[Role of cyclic nucleotides in carotid chemoreception].
The activation of the metabolic systems of rat carotid body under the influence of alkaloids and acids was studied by spectrofluorimetric technique. It has been demonstrated the growth of the cAMR levels being suggested to the role of messenger between chemical stimuli and the flows of glomus cells metabolism. Chemical substances of other types (such as acetylcholine, NaCl saccharose) don't provide any changes of cell respiration and concentration of cAMP in carotid cells. The data obtained provide the evidence of heterogeneity of glomus cella reception mechanisms of the qualitatively different chemical substances. It supports the hypothesis on the heterogeneity of chemoreception for mammals.
Samoĭlov
V O
VO
Ponomarenko
G N
GN
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002344:Carotid Body / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D000242:Cyclic AMP / Q000032:analysis; D009712:Nucleotides, Cyclic / Q000032:analysis / Q000502:physiology*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D013268:Stimulation, Chemical; D013395:Sucrose / Q000494:pharmacology
D009712:Nucleotides, Cyclic; D002110:Caffeine; D012965:Sodium Chloride; D013395:Sucrose; D000242:Cyclic AMP; D000109:Acetylcholine
O roli tsiklicheskikh nukleotidov v karotidnoĭ khimioreceptsii.