[Metabolism of vitamin D3 administered in liposomes in rat liver].
Incorporation of [3H]-cholecalciferol into the liver and the rate of its conversion into 25-OH-D are significantly larger after intravenous administration of this vitamin into liposomes than its dissolution in ethanol. The latter may be due to a different distribution of vitamin D3 in the cells of the liver. Incorporation of [3H]-vitamin D3 in reticulocytes suggests that its cells are a locus for storage of vitamin D, from which the latter is transported into hepatocytes where its 25-hydroxylation proceeds.
Apukhovskaia
L I
LI
Khrestovaia
N L
NL
Antonenko
L V
LV
D000818:Animals; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000378:metabolism; D004337:Drug Carriers; D008081:Liposomes; D008099:Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D004337:Drug Carriers; D008081:Liposomes; D002762:Cholecalciferol
Metabolizm vitamina D3, vvedennogo v liposomakh, v pecheni krys.