The effect of exercise associated with subchronic poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats.
The intestinal absorption of D-xylose was studied during the subchronic poisoning of male Wistar rats with orally administered potassium nitrate and sodium nitrite associated with exercise; running on a moving track during the last two weeks of poisoning. The metabolic parameters of Na+/K(+)-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level in the small intestine mucosa were determined one hour after D-xylose treatment. Exercise increased the toxicity of potassium nitrate and sodium nitrite. The experiment demonstrated post-exercise reduction of D-xylose absorption and decrease activity of Na+/K(+)-ATPase and alkaline phosphatase. Exercise caused transient hypoxia of the small intestine, which was observed only in the groups subjected to exercise on the day of the determinations.
Grudziński
I
I
Department of Food Studies and Nutrition Physiology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Szymański
A
A
Chomiczewski
K
K
D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D010101:Oxygen Consumption; D010805:Physical Conditioning, Animal; D017680:Potassium Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012977:Sodium Nitrite / Q000633:toxicity*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014994:Xylose / Q000493:pharmacokinetics*
D009566:Nitrates; D017680:Potassium Compounds; D014994:Xylose; D000469:Alkaline Phosphatase; D000254:Sodium-Potassium-Exchanging ATPase; D012977:Sodium Nitrite; C023844:potassium nitrate