Effect of interferon treatment on expression of gC and gE glycoproteins in herpes simplex virus-infected cells.
The effect of interferon treatment on the herpes simplex virus type 1 (HSV-1)-specific glycoproteins gC and gE in homologous and heterologous cells has been investigated. In human embryonic fibroblastic cells, human leukocyte interferon inhibited virus multiplication and expression of the HSV-1-specific glycoproteins gC and gE on the cell surface in a dose-dependent manner. In heterologous baby hamster kidney cells, the human interferon had no effect on virus multiplication. However, the surface expression of the HSV-1-specific glycoproteins was reduced, as shown by erythrocyte rosette formation, by attachment of monodisperse polystyrene particles coated with antibodies and by immunogold scanning electron microscopy.
Holberg-Petersen
M
M
Department of Virology, National Institute of Public Health, Oslo, Norway.
Böhmer
E
E
Namork
E
E
Degré
M
M
D000956:Antigens, Viral / Q000032:analysis; D002478:Cells, Cultured; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D011961:Receptors, Fc / Q000032:analysis; D018139:Simplexvirus / Q000032:analysis / Q000187:drug effects*; D014759:Viral Envelope Proteins / Q000032:analysis*; D014779:Virus Replication / Q000187:drug effects
D000956:Antigens, Viral; D007370:Interferon Type I; D011961:Receptors, Fc; D014759:Viral Envelope Proteins; C044768:glycoprotein E, herpes simplex virus type 1; C038535:glycoprotein gC, herpes simplex virus type 1