Activation of latent papillomavirus genomes by chronic mechanical irritation.
The skin of animals of a laboratory strain of Mastomys natalensis carrying endogenous, latent papillomavirus genomes was irritated by scratching with glasspaper. Hyperproliferation of the epidermis and amplification of viral DNA followed this treatment, and in approximately 27% of the animals virus-producing papillomas were induced.
Siegsmund
M
M
Institute for Experimental Pathology, German Cancer Research Center, Heidelberg.
Wayss
K
K
Amtmann
E
E
D000818:Animals; D015967:Gene Expression Regulation, Viral; D007700:Kinetics; D009115:Muridae; D027383:Papillomaviridae / Q000235:genetics*; D010812:Physical Stimulation; D012038:Regeneration; D012871:Skin Diseases / Q000382:microbiology*; D014412:Tumor Virus Infections / Q000382:microbiology*; D014775:Virus Activation