title: Squamous cell carcinoma arising in a case of vulvitis granulomatosa or vulval variant of Melkersson-Rosenthal syndrome.
abstract: A case of vulvitis granulomatosa or the vulval variant of Melkersson-Rosenthal syndrome (MRS) in a young adult patient with systemic lupus erythematosus is presented. She also had evidence of cervicovulvovaginal human papilloma virus (HPV) infection. Nine years later she developed a squamous cell carcinoma (SCC) of the vulva. HPV 6/11 was found by DNA in situ hybridization within a vulval condyloma as well as within the carcinoma. This case is unusual in that SCC associated with HPV 6/11 developed in her vulva affected by MRS rather than in the cervix, where SCC was more likely to occur considering this patient's age.
authors.affiliation: Department of Pathology, Royal Brisbane Hospital, Queensland, Australia.
authors.forename: H
authors.initials: H
authors.lastname: Samaratunga
authors.forename: G
authors.initials: G
authors.lastname: Strutton
authors.forename: R G
authors.initials: RG
authors.lastname: Wright
authors.forename: B
authors.initials: B
authors.lastname: Hill
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology; D008556:Melkersson-Rosenthal Syndrome / Q000150:complications* / Q000473:pathology; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000302:isolation & purification; D014412:Tumor Virus Infections / Q000150:complications / Q000473:pathology; D014846:Vulvar Neoplasms / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D014847:Vulvitis / Q000150:complications* / Q000473:pathology
chemical_list: D004273:DNA, Neoplasm