Peripheral neuropathy in a cohort of human immunodeficiency virus-infected patients. Incidence and relationship to other nervous system dysfunction.
A cohort of 94 patients infected with human immunodeficiency virus was evaluated clinically and electrophysiologically for the presence of peripheral neuropathy, and the results were compared with evaluations of central nervous system function. Thirty-two (34%) had some degree of peripheral neuropathy; 18 (19%) (six [12%] of the 49 asymptomatic patients, five [45%] of the 11 patients with acquired immunodeficiency syndrome [AIDS], and seven [21%] of the 34 patients with AIDS-related complex) had neuropathy on clinical examination; and 21 (23%) (eight [16%] asymptomatic, four [36%] AIDS, and nine [26%] AIDS-related complex) had neuropathy on electrophysiologic evaluation. There was a significant correlation between the presence of neuropathy and evidence of central nervous system dysfunction.
Hall
C D
CD
AIDS Neurologic Center, University of North Carolina School of Medicine, Chapel Hill 27599-7025.
Snyder
C R
CR
Messenheimer
J A
JA
Wilkins
J W
JW
Robertson
W T
WT
Whaley
R A
RA
Robertson
K R
KR
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D005071:Evoked Potentials; D015658:HIV Infections / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D011930:Reaction Time