[The effects of asbestos fibers on the protein kinase C activity in HL-60 cells. The role of free radicals].
It was confirmed that the function of DMSO as an inducer of cell differentiation was suppressed by co-culture of crocidolite asbestos, using the activity of protein kinase C as indicator, because DMSO reacted with .OH radical released by stimulation with crocidolite and wasted itself. SOD inhibited the effect of crocidolite, because SOD reacted with .O2- released by stimulation with crocidolite and inhibited the subsequent development of .OH.
Ueki
A
A
Department of Hygiene, Kawasaki Medical School.
Tsushima
H
H
Hyodoh
F
F
Kinugawa
K
K
D001194:Asbestos / Q000009:adverse effects / Q000494:pharmacology*; D017638:Asbestos, Crocidolite; D002455:Cell Division / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005609:Free Radicals; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D010100:Oxygen / Q000502:physiology; D011493:Protein Kinase C / Q000187:drug effects* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology
D005609:Free Radicals; D017638:Asbestos, Crocidolite; D001194:Asbestos; D011493:Protein Kinase C; D010100:Oxygen; D004121:Dimethyl Sulfoxide