title: HLA antigens and bronchogenic carcinoma in the Greek population.
abstract: The distribution of HLA antigens was studied in 85 Greek patients with bronchogenic carcinoma. Fifty-seven specific HLA antisera were used to determine 27 HLA-A and B antigens, with the two-stage standard NIH microlymphocytotoxicity assay. The results were compared with those in a control group, consisting of 400 healthy individuals. In the whole group of patients there was a significantly higher frequency of HLA-AW19 and HLA-A29 (p less than 0.003 and p less than 0.006 respectively) and a lower frequency of HLA-A2 and HLA-A3 (p less than 0.014 and p less than 0.006 respectively) than in the control population. In patients with squamous cell carcinoma there was a significantly higher frequency of HLA-AW19 and lower frequency of HLA-A2 (p less than 0.02 and p less than 0.05 respectively). In small cell carcinoma patients there was a significantly lower frequency of HLA-A3 (p less than 0.04) than among the controls. In patients with adenocarcinoma no significant change of HLA antigen frequencies was observed when compared to the controls.
authors.affiliation: Second Department of Chest Medicine, Athens Hospital of Chest Diseases, Greece.
authors.forename: M
authors.initials: M
authors.lastname: Toumbis
authors.forename: J
authors.initials: J
authors.lastname: Zervas
authors.forename: O
authors.initials: O
authors.lastname: Anagnostopoulou
authors.forename: K
authors.initials: K
authors.lastname: Konstantopoulos
authors.forename: G
authors.initials: G
authors.lastname: Krimbeni
authors.forename: V
authors.initials: V
authors.lastname: Kotsovoulou
authors.forename: F
authors.initials: F
authors.lastname: Fessas
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology; D002283:Carcinoma, Bronchogenic / Q000276:immunology* / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000276:immunology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology; D005260:Female; D006115:Greece; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens