title: Human cytomegalovirus glycoprotein-receptor interactions.
abstract: The HCMV envelope glycoprotein having a molecular weight of 86 kd, gH, has been shown to react with a 92 kd protein that can be extracted from HEL fibroblasts. This HCMV-gp86 membrane receptor appears to be present on the surface of both HCMV-permissive and HCMV-non-permissive cells, suggesting that there are factors in addition to viral attachment governing the intracellular replicative process. Another HCMV envelope glycoprotein (gp130/55; gB homologue) binds predominantly to a 31 kd protein with minor bands at 180, 96, and 90 kd. HCMV-gp86 does not bind to the principal gp130/55 receptor.
authors.affiliation: Division of Infectious Diseases, Stanford University School of Medicine, California.
authors.forename: L
authors.initials: L
authors.lastname: Rasmussen
authors.forename: S
authors.initials: S
authors.lastname: Resta
authors.forename: T
authors.initials: T
authors.lastname: Merigan
mesh_terms: D000911:Antibodies, Monoclonal; D003587:Cytomegalovirus / Q000502:physiology*; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D011991:Receptors, Virus / Q000502:physiology*; D014759:Viral Envelope Proteins / Q000276:immunology / Q000378:metabolism*; D014779:Virus Replication
chemical_list: D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D011991:Receptors, Virus; D014759:Viral Envelope Proteins