Tumours of mesothelial origin in rats following inoculation with biogenic silica fibres.
Pleural implant experiments using Sprague-Dawley rats have shown that those injected with the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenenthren-17-one (11-methyl-17-ketone) intraperitoneally followed by silica fibres intrapleurally develop mesotheliomas. These tumours were histologically similar to those induced by crocidolite alone. The intraperitoneal injection of 11-methyl-17-ketone also induced leukaemia.
Bhatt
T S
TS
Joint Academic Unit of Obstetrics, Gynaecology and Reproductive Physiology, Royal London Hospital, Whitechapel, UK.
Lang
S
S
Sheppard
M N
MN
D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D006067:Gonanes / Q000633:toxicity; D007267:Injections; D007274:Injections, Intraperitoneal; D007951:Leukemia, Myeloid / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced*; D010212:Papilloma / Q000139:chemically induced; D010994:Pleura; D051381:Rats; D011919:Rats, Inbred Strains; D012822:Silicon Dioxide / Q000633:toxicity*
D002273:Carcinogens; D006067:Gonanes; D012822:Silicon Dioxide; C005765:15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one