Phosphorothioate oligodeoxynucleotides--anti-sense inhibitors of gene expression?
Phosphorothioate (PS) oligodeoxynucleotides are relatively nuclease resistant, water soluble analogs of phosphodiester (PO) oligodeoxynucleotides. These molecules are chiral but still hybridize well to their RNA targets. While considered for use as in vivo anti-sense inhibitors of gene expression, their biology, especially in the anti-viral area, is dominated by non-sequence specific effects. This review discusses both the sequence and non-sequence specific biologic effects of PS oligomers, and attempts to more clearly indicate their ultimate therapeutic potential.
Stein
C A
CA
Department of Medicine, Columbia University Comprehensive Cancer Center, New York, NY 10032.
Tonkinson
J L
JL
Yakubov
L
L
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D006824:Hybridization, Genetic / Q000187:drug effects; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D063086:Organothiophosphates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D016376:Oligonucleotides, Antisense; D063086:Organothiophosphates