Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats.
Injections of high doses of etorphine (0.0625, 0.25, or 1.0 mumol) or equimolar fentanyl into the cerebral ventricles of rats induced a sequence of motor effects including catatonia, a novel flaccid paralysis, and recurrent catatonia. These effects were dose related, naloxone reversible, and reveal an opiate specific organization of a central motor hierarchy.
Leshem
M
M
Department of Psychology, University of Haifa, Israel.
Frenk
H
H
Coghill
R C
RC
Mayer
D J
DJ
D000818:Animals; D005048:Etorphine / Q000008:administration & dosage / Q000494:pharmacology*; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007278:Injections, Spinal; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010243:Paralysis / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects*
D011957:Receptors, Opioid; D009270:Naloxone; D005048:Etorphine; D005283:Fentanyl