[The action of low doses of bromocryptin in experimental morphine abstinence in rats].
In experiments on rats which consumed for a long time morphine solution as a drinking liquid there was studied the effect of low doses of bromocriptine on the behavioural manifestations of morphine abstinence syndrome and the condition of the noradrenergic, dopaminergic and conjugated GABAergic systems of the brain. It was shown that the preliminary administration of bromocriptine decreased the degree of the withdrawal syndrome that correlated with the restoration of dopamine content and the normalization of the condition of D2-dopaminergic receptors in different regions of the brain. Bromocriptine exerted no influence on the morphine withdrawal-induced changes in the condition of GABA receptors of the cerebral cortex.
Stanishevskaia
A V
AV
Khristoliubova
N A
NA
Vekshina
N L
NL
Varfolomeev
S O
SO
Anokhina
I P
IP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D001971:Bromocriptine / Q000008:administration & dosage* / Q000494:pharmacology; D004298:Dopamine / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000032:analysis / Q000187:drug effects; D011954:Receptors, Dopamine / Q000032:analysis / Q000187:drug effects; D011963:Receptors, GABA-A / Q000032:analysis / Q000187:drug effects; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000378:metabolism
D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D001971:Bromocriptine; D009020:Morphine; D004298:Dopamine; D009638:Norepinephrine
Deĭstvie malykh doz bromokriptina pri éksperimental'noĭ morfinnoĭ abstinentsii u krys.