title: In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh.
abstract: The design of a skin-substitute must address the need for a dermal component, as this mesenchymally-derived tissue is important in maintaining the integrity and function of skin. An in vivo study was undertaken to assess the use of two biodegradable meshes, polyglycolic acid and polyglactin-910, as carriers for cultured human fibroblasts in a living dermal replacement. The consistent vascularization and epithelialization of these grafts placed on athymic mice showed that this has potential in re-creating the dermis in a skin-substitute.
authors.affiliation: Department of Surgery, University of California, San Diego Medical Center 92103.
authors.forename: M L
authors.initials: ML
authors.lastname: Cooper
authors.forename: J F
authors.initials: JF
authors.lastname: Hansbrough
authors.forename: R L
authors.initials: RL
authors.lastname: Spielvogel
authors.forename: R
authors.initials: R
authors.lastname: Cohen
authors.forename: R L
authors.initials: RL
authors.lastname: Bartel
authors.forename: G
authors.initials: G
authors.lastname: Naughton
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001673:Biodegradation, Environmental; D001684:Biological Dressings; D002478:Cells, Cultured; D003094:Collagen / Q000032:analysis; D005347:Fibroblasts; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D011098:Polyglactin 910; D011100:Polyglycolic Acid; D013526:Surgical Mesh; D014945:Wound Healing / Q000502:physiology
chemical_list: D011100:Polyglycolic Acid; D011098:Polyglactin 910; D003094:Collagen