title: Clomipramine in autism: preliminary evidence of efficacy.
abstract: This report provides preliminary evidence for the efficacy of clomipramine in the treatment of young adults with autistic disorder. Four of five outpatients with autistic disorder showed significant improvement in social relatedness, obsessive compulsive symptoms, and aggressive and impulsive behavior with clomipramine treatment. These findings are consistent with previous evidence, suggesting that serotonin neurotransmission may be relevant to the treatment, and possibly the pathophysiology, of some symptoms of autistic disorder.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
authors.forename: C J
authors.initials: CJ
authors.lastname: McDougle
authors.forename: L H
authors.initials: LH
authors.lastname: Price
authors.forename: F R
authors.initials: FR
authors.lastname: Volkmar
authors.forename: W K
authors.initials: WK
authors.lastname: Goodman
authors.forename: D
authors.initials: D
authors.lastname: Ward-O'Brien
authors.forename: J
authors.initials: J
authors.lastname: Nielsen
authors.forename: J
authors.initials: J
authors.lastname: Bregman
authors.forename: D J
authors.initials: DJ
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression / Q000187:drug effects; D001321:Autistic Disorder / Q000188:drug therapy* / Q000523:psychology; D002997:Clomipramine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000523:psychology; D012919:Social Behavior
chemical_list: D002997:Clomipramine