title: The neuronal mechanism underlying parkinsonism and dyskinesia: differential roles of the putamen and caudate nucleus.
abstract: The basal ganglia were manipulated pharmacologically by using GABA antagonists and also 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in rats, cats and monkeys, and neuronal activities were recorded from the basal ganglia. It was concluded that: (1) in parkinsonism, neuronal activities of the caudate nucleus decreased, those of the pars reticulata of the substantia nigra and the internal segment of the globus pallidus increased, and those of the ventromedial nucleus of the thalamus were depressed markedly; (2) in dyskinesia, periodical discharges of the caudate-putamen complex were the primary event in rodents, resulting in activation of the thalamus; and (3) the caudate nucleus was involved in the manifestation or driving of locomotion, while the putamen was related to regulation of tonus in contralateral muscles with proximal dominancy.
authors.affiliation: Department of Neurology, Jichi Medical School, Tochigi-ken, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D001479:Basal Ganglia / Q000503:physiopathology; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D008252:Macaca fascicularis; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology*; D011699:Putamen / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
chemical_list: D010566:Virulence Factors, Bordetella; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine