title: Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.
abstract: Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
authors.affiliation: Istituto di Farmacologia, Facoltà di Medicina, Università di Catania.
authors.forename: A
authors.initials: A
authors.lastname: Copani
authors.forename: G
authors.initials: G
authors.lastname: Raciti
authors.forename: V
authors.initials: V
authors.lastname: Bruno
authors.forename: M A
authors.initials: MA
authors.lastname: Sortino
authors.forename: F
authors.initials: F
authors.lastname: Nicoletti
authors.forename: P L
authors.initials: PL
authors.lastname: Canonico
authors.forename: A
authors.initials: A
authors.lastname: Cambria
mesh_terms: D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010833:Phytic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D015290:Second Messenger Systems; D013268:Stimulation, Chemical
chemical_list: D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; C068271:inositol hexakisphosphate receptor; D010833:Phytic Acid; D002118:Calcium