Synthesis of [18F]fluoro-labeled progestins for PET.
The synthesis of 21-[18F]fluoro-16 alpha-methyl-19-norprogesterone, 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone, 21-[18F]fluoro-16 alpha-methylprogesterone and 21-[18F]fluoro-16 alpha-ethylprogesterone is described. These compounds are prepared with a specific activity greater than 200 TBq/mmol (5000 Ci/mmol) from the corresponding tosylates in 10% radiochemical yield (EOB). A remote controlled system has been developed for this synthesis.
de Groot
T J
TJ
PET Center, University of Groningen, The Netherlands.
Verhagen
A
A
Elsinga
P H
PH
Vaalburg
W
W
D005462:Fluorine Radioisotopes; D007553:Isotope Labeling / Q000379:methods*; D011374:Progesterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D011374:Progesterone