Choosing a cell fate: a view from the Notch locus.
During the development of Drosophila melanogaster, individual cells must make choices between a restricted set of possible fates in order to give rise to spatial patterns composed of different types of differentiated cells. The Notch locus appears to play a central and general role in the regulative events that control the local architecture of the final cellular pattern in several tissues, among them being the central and peripheral nervous systems.
Artavanis-Tsakonas
S
S
Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, CT 06511.
Simpson
P
P
D000818:Animals; D002454:Cell Differentiation; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology* / Q000235:genetics; D004475:Ectoderm; D047108:Embryonic Development; D005314:Embryonic and Fetal Development; D004843:Epistasis, Genetic; D005246:Feedback; D005786:Gene Expression Regulation; D005796:Genes; D007301:Insect Hormones / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D009030:Mosaicism; D009420:Nervous System / Q000196:embryology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D051880:Receptors, Notch
D029721:Drosophila Proteins; D007301:Insect Hormones; D008565:Membrane Proteins; C497759:N protein, Drosophila; D011956:Receptors, Cell Surface; D051880:Receptors, Notch