Metabolism of glycogen in submandibular glands of rats. Alteration by NaF.
Submandibular glands of rats injected with NaF solution (10 mg F-/kg body weight) were analysed for glycogen content and phosphorylase activity after various time intervals. In contrast to what has been reported for the liver, sodium fluoride caused increased glycogen content. Phosphorylase (a and total) activity was not affected, suggesting a different mechanism of action of F- in the submandibular gland. In vivo experiments demonstrated stimulation of glycogenesis.
Nicolau
J
J
Universidade de Sao Paulo, Departamento de Bioquimica, Instituto de Quimica USP, Sao Paulo, Brasil.
Ribeiro
D M
DM
D000818:Animals; D004334:Drug Administration Schedule; D006003:Glycogen / Q000032:analysis / Q000378:metabolism*; D008297:Male; D010762:Phosphorylase a / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*; D013217:Starvation; D013363:Submandibular Gland / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D012969:Sodium Fluoride; D006003:Glycogen; D010762:Phosphorylase a