Correlation of mutations of oncogene C-Ha-ras at codon 12 with metastasis and survival of gastric cancer patients.
Mutations of c-Ha-ras at codon 12 were detected from 11 out of 27 fresh tissues and cell-lines of human gastric cancer patients using PCR-restriction analysis. Further statistical investigation showed that the presence of point mutations was related to the distal metastases and the survival time of gastric cancer patients after surgical operations.
Deng
G R
GR
Department of Biochemistry, Beijing Institute for Cancer Research, China.
Liu
X H
XH
Wang
J R
JR
D004591:Electrophoresis, Polyacrylamide Gel; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality