title: Multicentric gliomas. Report of seven cases.
abstract: Multifocal gliomas fall into four main categories: diffuse, multiple, multicentric and multiple-organ. Multicentric gliomas are uncommon lesions of the central nervous system. Even more so are multicentric gliomas lying both above and below the tentorium (16 cases to date, as far we know). We report a clinical series of 7 cases, including 3 supra-infratentorial tumors. The distinctive features of multicentric gliomas are mainly the absence of gross or microscopic connections and absence of seeding along easily accessible routes like the cerebrospinal fluid pathways or the median commissures. We consider the pathogenetic hypotheses and problems of diagnosis, especially differential from other multifocal diseases of the central nervous system.
authors.affiliation: Department of Neurological Sciences-Neurosurgery, University of Rome, La Sapienza, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Salvati
authors.forename: P A
authors.initials: PA
authors.lastname: Oppido
authors.forename: S
authors.initials: S
authors.lastname: Artizzu
authors.forename: F
authors.initials: F
authors.lastname: Fiorenza
authors.forename: F
authors.initials: F
authors.lastname: Puzzilli
authors.forename: E R
authors.initials: ER
authors.lastname: Orlando
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging / Q000473:pathology*; D005910:Glioma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed