Excitatory action of some aspartate- and glutamate-containing dipeptides after intracerebroventricular injection in mice.
The effects of some dipeptides, analogues of N-acetyl-alpha-L-aspartyl-L-glutamate, were studied after i.c.v. administration into mice in acute experiments. N-Acetyl-alpha-L-aspartyl-L-glutamate itself did not induce seizures in animals, but prevented glutamate-induced convulsions. All other dipeptides possessed excitatory glutamate-like actions. Some structural requirements for the excitatory effects of the dipeptides are discussed.
Garyaev
A P
AP
Department of Pharmacology, Academy of Medical Sciences U.S.S.R., Leningrad.
Dumpis
M A
MA
Poznjakova
L N
LN
Zaitzev
Y V
YV
Piotrovsky
L B
LB
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003292:Convulsants; D004151:Dipeptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology; D007276:Injections, Intraventricular; D051379:Mice; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D003292:Convulsants; D004151:Dipeptides; D005971:Glutamates; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; C011829:glutamic acid diethyl ester; C027172:isospaglumic acid