Lack of plasmic beta-endorphin response to a gastronomic meal in healthy humans.
In order to study the relationship between the endogenous opiate system and food intake in man, plasma concentrations of beta-endorphin were measured in ten healthy subjects. Time course of beta-endorphinemia was compared under the following conditions: basal (fasting), after an injection of pentagastrin (6 micrograms/kg), or after a gastronomic meal. No changes in plasma beta-endorphin or ACTH concentrations were observed with pentagastrin nor after the meal, despite the combination of very high sensory pleasure with intake of a very large amount of food. It is concluded that blood beta-endorphin concentration is not a sensitive index of the effects of food intake on the endogenous opioid system in man.
Melchior
J C
JC
Laboratoire de Nutrition Humaine, Unité Inserm U286, CHU Bichat, Paris, France.
Fantino
M
M
Colas-Linhart
N
N
Rigaud
D
D
Petiet
A
A
Laforest
M D
MD
Fumeron
F
F
Apfelbaum
M
M
D000328:Adult; D000339:Affect / Q000502:physiology; D001066:Appetite / Q000502:physiology*; D001143:Arousal / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D004435:Eating / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology; D006801:Humans; D006815:Hunger / Q000502:physiology; D008297:Male; D011957:Receptors, Opioid / Q000502:physiology; D013649:Taste / Q000502:physiology*; D001615:beta-Endorphin / Q000097:blood*
D001786:Blood Glucose; D011957:Receptors, Opioid; D001615:beta-Endorphin