Effects of peripheral type benzodiazepine antagonist PK 11195 on the lipid-lowering activity of diazepam in albino rats.
The i.p. administration of PK 11195, a peripheral type benzodiazepine receptor antagonist in a dose of 1 mg/kg/day antagonized the action of u.p. injection of diazepam (5 mg/kg/day, 5 days) on serum triglycerides. It seems that the effects of diazepam on serum lipids were due to the stimulation of the peripheral type benzodiazepine receptors.
Cuparencu
B
B
Department of Pharmacology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Horák
J
J
D000818:Animals; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004041:Dietary Fats / Q000009:adverse effects; D058787:GABA-A Receptor Antagonists; D007546:Isoquinolines / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D058787:GABA-A Receptor Antagonists; D007546:Isoquinolines; D008055:Lipids; D014280:Triglycerides; D003975:Diazepam; C037850:PK 11195