Ionization state of myo-inositol 1,4,5-trisphosphate: correlation with binding properties.
The comparison between the ionization state and the binding properties on brain membrane receptors of the synthetized myo-inositol 1,4,5-trisphosphate lead to the conclusion that the biological active species may be either the monoprotonated or the fully deprotonated trisphosphate.
Schmitt
L
L
Centre de Neurochimie du CNRS, Départment de Pharmacochimie Moléculaire, Strasbourg, France.
Schlewer
G
G
Spiess
B
B
D015220:Calcium Channels; D006863:Hydrogen-Ion Concentration; D015544:Inositol 1,4,5-Trisphosphate / Q000031:analogs & derivatives; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates / Q000737:chemistry*; D008968:Molecular Conformation; D009946:Organothiophosphorus Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D011522:Protons; D011956:Receptors, Cell Surface / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007295:Inositol Phosphates; D009946:Organothiophosphorus Compounds; D011522:Protons; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; C054737:inositol 1,4,5-triphosphorothioate; D015544:Inositol 1,4,5-Trisphosphate