Anesthetic and nephrotoxic effects of Telazol in New Zealand white rabbits.
Telazol was evaluated as an anesthetic for rabbits. Two groups of five rabbits each were injected intramuscularly with 32 or 64 mg/kg of Telazol, and the depth and duration of anesthesia period monitored. At both doses, the righting reflex was lost within 2 minutes postinjection. Animals in both groups responded to noxious stimuli for the duration of the anesthesia. Hematology and urinalyses were performed daily for 7 days postinjection. Hematologic parameters remained unchanged in both groups. In the high-dose group, blood urea nitrogen and serum creatinine levels increased 1 day postinjection and continued steadily throughout the week. Elevations in urine protein and the presence of casts correlated with this increase. In the low-dose group, blood urea nitrogen and creatinine levels increased and protein was present in the urine of four of five rabbits beginning approximately 5 days postinjection. Histologically, severe renal tubular necrosis was evident 7 days postinjection in all high-dose rabbits and in three rabbits in the low-dose group. Our results indicate that Telazol does not produce analgesia in rabbits and is nephrotoxic at both 32 and 64 mg/kg. We conclude that Telazol is contraindicated for use in rabbits.
Brammer
D W
DW
Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor 48109-0614.
Doerning
B J
BJ
Chrisp
C E
CE
Rush
H G
HG
D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D011817:Rabbits; D013045:Species Specificity; D013992:Tiletamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D015041:Zolazepam / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D015041:Zolazepam