Neurotensin inhibits the stimulatory effect of angiotensin-II and potassium on aldosterone secretion by rat zona glomerulosa cells.
Neurotensin (NT), a hypothalamic peptide which is also contained in the chromaffin granules of adrenal medullary cells, did not affect either basal or ACTH-stimulated secretory activity of isolated rat zona glomerulosa (ZG) cells. Conversely, NT was found to exert a strong dose-dependent inhibitory effect on aldosterone response of ZG cells to their two main calcium-dependent secretagogues angiotensin-II and potassium. These findings suggest that NT may interfere with the angiotensin-II- or potassium-induced activation of protein kinase C, possibly by blunting the rise in the cytosolic calcium concentration.
Mazzocchi
G
G
Department of Anatomy, University of Padua, Italy.
Malendowicz
L K
LK
Andreis
P G
PG
Nussdorfer
G G
GG
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000378:metabolism*; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009496:Neurotensin / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D015384:Zona Glomerulosa / Q000187:drug effects / Q000378:metabolism*
D000804:Angiotensin II; D009496:Neurotensin; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D011188:Potassium