[Indicators of prostaglandin synthase activity in thrombocytes of patients with schizophrenia with positive and negative disorders].
A study was made of the activity of prostaglandin-synthetase in isolated platelets from the 2 groups of schizophrenic patients: with the predominance of positive (group I) and negative (group II) disorders. It has been demonstrated that the activity of prostaglandin-synthetase in isolated platelets from patients with hallucinatory delirium++ disorders is considerably higher (p less than 0.01) than the activity of prostaglandin-synthetase in isolated platelets from patients with the predominance of negative symptoms. The data obtained once more raise a question of the ++patho-chemical heterogeneity of schizophrenia, which also pertains to prostaglandins. The authors discuss a possibility of the relationship in schizophrenic patients between the regulatory system of prostaglandin synthesis and the central hypothalamohypophyseal mechanism by which homeostasis is regulated.
Geling
N G
NG
Klimenko
T V
TV
Milekhin
G N
GN
D000328:Adult; D000341:Affective Disorders, Psychotic / Q000097:blood* / Q000209:etiology; D001792:Blood Platelets / Q000201:enzymology*; D003072:Cognition Disorders / Q000097:blood* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009341:Negativism; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood*; D012559:Schizophrenia / Q000097:blood* / Q000150:complications; D012565:Schizophrenic Psychology
D011451:Prostaglandin-Endoperoxide Synthases
Pokazateli aktivnosti prostaglandin-sintetazy trombotsitov u bol'nykh shizofrenieĭ s pozitivnymi i negativnymi rasstroĭstvami.