Human interleukin 4.
Human IL-4 is a mature 129 AA glycoprotein, mostly secreted by activated T cells. It is a pleiotropic cytokine which acts on T and B lymphocytes, monocytes, polymorphonuclear cells, fibroblasts and endothelial cells. In addition it acts at various stages of cell differentiation and its effects are also dependent on the cytokine environment. In particular, IL-4 blocks some of the effects of IL-2 whereas interferon gamma blocks some of the effects of IL-4. In vitro and in vivo experiments in mouse and in vitro experiments in man have shown that IL-4 plays a crucial role in the induction of IgE production, whereas interferons counteract this effect. Human IL-4 binds to a high affinity receptor which is composed at least of one 130-kDa glycoprotein of 800 AA, a member of the newly described hematopoietin receptor superfamily. IL-4 may prove useful as an antitumoral and antiinflammatory agent.
Banchereau
J
J
Schering-Plough, Laboratory for Immunological Research, Dardilly, France.
Defrance
T
T
Galizzi
J P
JP
Miossec
P
P
Rousset
F
F
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects; D006801:Humans; D015847:Interleukin-4 / Q000378:metabolism / Q000494:pharmacology; D051379:Mice; D011956:Receptors, Cell Surface; D013601:T-Lymphocytes / Q000187:drug effects
D011956:Receptors, Cell Surface; D015847:Interleukin-4