title: [Continuous intravenous infusion versus intermittent administration of streptokinase in patients with deep venous thrombosis of the lower extremity].
abstract: In a multicenter randomized trial, the efficacy and safety of two streptokinase (SK) dosage regimens have been evaluated in patients with proximal deep vein thrombosis of inferior limbs. Twenty-nine patients received SK by a continuous intravenous infusion (250,000 IU as initial dose, 100,000 IU/h as maintenance dose), and 26 patients were treated with intermittent SK administration (500,000 IU as initial dose, followed by 250,000 IU every 12 h). Thrombolytic therapy was continued for 4 days, then the patients received heparin for 5 days and oral anticoagulant for 3 months. The results of treatment as judged by phlebographic examinations were similar in the two groups. Complete, substantial or partial thrombolysis was achieved in 52% of patients in the continuous infusion group and in 58% of patients in the intermittent treatment group. During SK administration, major bleeding complications occurred in 6 patients treated by continuous infusion and in 2 of the second group. The results showed that the intermittent SK administration is as effective and safe as the method of continuous SK infusion in the treatment of deep vein thrombosis.
authors.affiliation: Samodzielnej Pracowni Krzepniecia Krwi.
authors.forename: S
authors.initials: S
authors.lastname: Lopaciuk
authors.forename: A J
authors.initials: AJ
authors.lastname: Meissner
authors.forename: J M
authors.initials: JM
authors.lastname: Ziemski
authors.forename: A
authors.initials: A
authors.lastname: Tokarz
authors.forename: P
authors.initials: P
authors.lastname: Psuja
authors.forename: K
authors.initials: K
authors.lastname: Zawilska
authors.forename: S
authors.initials: S
authors.lastname: Głowiński
authors.forename: Z
authors.initials: Z
authors.lastname: Wołczyński
authors.forename: E
authors.initials: E
authors.lastname: Czestochowska
authors.forename: W
authors.initials: W
authors.lastname: Tymiński
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D013924:Thrombophlebitis / Q000188:drug therapy*
chemical_list: D013300:Streptokinase
vernacular_title: Ciagły wlew dozylny i przerywane stosowanie streptokinazy u chorych na zakrzepice zył głebokich kończyn dolnych.