Novel polyphosphoinositides in cell growth and activation.
The "conventional" polyphosphoinositide pathway is important for the transmission and amplification of signals across the cell membrane. Ligand-induced activation of phospholipase C results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to produce the well-characterized second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Recently, three novel polyphosphoinositides have been implicated as important signaling molecules for cell proliferation and activation. These lipids are phosphorylated in the D-3 position of the inositol ring and appear to represent branch points from the conventional polyphosphoinositide pathway.
Auger
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KR
Physiology Department, Tufts University School of Medicine, Boston, Massachusetts 02111.
Cantley
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LC
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols