The thyroid function and size in healthy man during 3 weeks treatment with beta-adrenoceptor-antagonists.
The influence of beta-adrenoceptor antagonists on serum TSH level (supersensitive method) and thyroid volume has not previously been studied. Thirty-two young non-smoking males were treated for 3 weeks with either atenolol 50 mg (b.i.d.), metoprolol 100 mg (b.i.d.) or propranolol 80 mg (b.i.d.) in a placebo controlled study. After 1 week, median serum TSH level increased in the atenolol (from 1.76 (range: 0.96-4.04) to 2.25 (range: 1.11-4.22) mU/l, P less than 0.05) and propranolol (from 1.91 (range: 0.90-3.83) to 2.44 (range: 0.75-6.30) mU/l, P less than 0.05) treated groups. After 3 weeks, median serum TSH reached pretreatment level in the atenolol treated, whereas median serum TSH decreased compared to pretreatment values in the propranolol treated (1.68 (range: 0.68-3.62) mU/l, P less than 0.05). Except for a slight increase in the atenolol treated group, no changes in median thyroid volume was seen after 3 weeks. The changes in serum TSH or thyroid volume were not related to changes in the concentrations of thyroid hormones, or of a magnitude likely to interfere with the clinical evaluation of thyroid function.
Kayser
L
L
Dept. of Internal Medicine and Endocrinology F, Herlev University Hospital, Denmark.
Perrild
H
H
Feldt-Rasmussen
U
U
Hegedüs
L
L
Skovsted
L
L
Hansen
J E
JE
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol / Q000494:pharmacology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013961:Thyroid Gland / Q000033:anatomy & histology* / Q000187:drug effects / Q000502:physiology; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D000319:Adrenergic beta-Antagonists; D014284:Triiodothyronine; D001262:Atenolol; D013972:Thyrotropin; D011433:Propranolol; D008790:Metoprolol; D013974:Thyroxine