[Induction of unstable mutations in Drosophila melanogaster by microinjection of oncogenic virus DNA into the embryo polar plasma. Insertional nature of mutations].
We have demonstrated that mutations induced in Drosophila melanogaster by the microinjections of adenovirus Sa7 DNA in early embryos are of insertional nature. The role of insertional elements is played by the Drosophila transposons, but not by the virus DNA. The ability of oncoviral DNA to induce transpositions of mobile elements in recipient genome is the molecular basis of this system of genetic instability.
Nabirochkin
S D
SD
Georgieva
S G
SG
Begetova
T V
TV
Georgiev
P G
PG
Makarova
I V
IV
Gerasimova
T I
TI
Gazarian
K G
KG
D000256:Adenoviridae / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D004251:DNA Transposable Elements / Q000502:physiology; D004279:DNA, Viral / Q000235:genetics*; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics; D008845:Microinjections; D016254:Mutagenesis, Insertional / Q000235:genetics*
D004251:DNA Transposable Elements; D004279:DNA, Viral
Induktsiia nestabil'nyukh mutatsiĭ u Drosophila melanogaster mikroin"ektsieĭ DNK onkogennykh virusov v poliarnuiu plazmu émbrionov. Insertsionnaia priroda mutatsii.