title: Cytochrome P450IIE1 metabolism of pyridines: evidence for production of a reactive intermediate which exhibits redox-cycling activity and causes DNA damage.
authors.affiliation: Institute of Chemical Toxicology, Wayne State University, Detroit, MI 48201.
authors.forename: S G
authors.initials: SG
authors.lastname: Kim
authors.forename: R F
authors.initials: RF
authors.lastname: Novak
mesh_terms: D000818:Animals; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004249:DNA Damage; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D011725:Pyridines / Q000378:metabolism* / Q000633:toxicity; D011817:Rabbits; D013481:Superoxides / Q000378:metabolism
chemical_list: D011725:Pyridines; D013481:Superoxides; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D010089:Oxidoreductases, N-Demethylating; D005978:Glutathione