Kinetics of the dual-action mechanism of narcotic substances: conditions for conservative functioning of enzyme-receptor systems.
We have studied the kinetics of the conservative behavior of systems which are subject to the dual action of an external effector or a negative feedback. Conditions have been found under which the dual-action mechanism produces conservative behavior. Negative feedback alone was shown not to produce the conservative behavior of an enzyme-receptor system.
Ilyina
A D
AD
M.V. Lomonosov Moscow State University, USSR.
Zaitsev
S V
SV
Varfolomeyev
S D
SD
D004798:Enzymes / Q000378:metabolism*; D005246:Feedback; D007700:Kinetics; D008954:Models, Biological; D009294:Narcotics / Q000493:pharmacokinetics / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism
D004798:Enzymes; D009294:Narcotics; D011956:Receptors, Cell Surface