Antiviral activity of constituents of Tamus communis.
The antiviral activity of the phenanthrene derivatives 1-6, of the spyrostane triglycosides dioscin (7) and gracillin (8), of the furostanol tetraglycosides methylprotodioscin (9), its (25S) epimer methylprotoneodioscin (10), and methylprotogracillin 11, have been tested towards two RNA viruses: vesicular stomatitis virus and human rhinovirus type 1B. All these products were extracted from the rizomes of Tamus communis L; compound 11 was isolated also from Asparagus cochinchinesis, together with pseudoprotodioscin (12), a 20 (22)-unsaturated furostanoside, which was also investigated for antiviral activity. The results were of some interest mainly for the phenanthrene derivatives.
Aquino
R
R
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli, Italy.
Conti
C
C
De Simone
F
F
Orsi
N
N
Pizza
C
C
Stein
M L
ML
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D010946:Plants, Medicinal; D012367:RNA, Viral; D012229:Rhinovirus / Q000187:drug effects* / Q000502:physiology; D013150:Spirostans / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D012367:RNA, Viral; D013150:Spirostans; C044934:gracillin; C019357:dioscin; D004144:Diosgenin