CD4+ monocyte counts in persons with HIV-1 infection: an early increase is followed by a progressive decline.
In this study, we asked whether there is a difference in the number of CD4+ and CD4- peripheral blood monocytes as CD4+ T cells decrease during HIV-mediated immunodeficiency. Monocytes and T cells from 90 HIV-positive and 43 HIV-negative persons were analyzed by flow cytometry. The 90 HIV-positive patients represented the entire spectrum of CD4+ T-cell counts. We report that as CD4+ T cells decrease, the number of CD4+ monocytes decrease in parallel. Moreover, significantly higher CD4+ monocyte counts were observed in persons with early stage HIV disease, i.e., greater than 800 CD4+ T cells/mm3, than in HIV-negative persons with greater than 800 CD4+ T cells/mm3. Potential implications of these findings are discussed.
Lucey
D R
DR
Department of Medicine, Wilford Hall USAF Medical Center, Lackland AFB, San Antonio, Texas.
Hensley
R E
RE
Ward
W W
WW
Butzin
C A
CA
Boswell
R N
RN
D000704:Analysis of Variance; D015704:CD4 Antigens / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005434:Flow Cytometry; D006679:HIV Seropositivity / Q000097:blood*; D015497:HIV-1; D006801:Humans; D007958:Leukocyte Count; D009000:Monocytes / Q000276:immunology*
D015704:CD4 Antigens