Influence of site of expression on the fetal gamma delta T-cell receptor repertoire.
The sequences of productive T-cell gamma/delta receptor transcripts were compared in different murine fetal tissues. Differences from tissue to tissue suggest that the sequence repertoires are at least in part the products of selection, presumably through interaction of T cells bearing the gamma delta receptor with fetal self-ligands.
Kyes
S
S
Department of Biology, Yale University, New Haven, CT 06511.
Pao
W
W
Hayday
A
A
D000818:Animals; D001483:Base Sequence; D005333:Fetus; D015870:Gene Expression; D015329:Gene Rearrangement, T-Lymphocyte; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D007422:Intestines / Q000196:embryology / Q000276:immunology; D008099:Liver / Q000196:embryology / Q000276:immunology; D046911:Macromolecular Substances; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D005810:Multigene Family; D015345:Oligonucleotide Probes; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D012867:Skin / Q000196:embryology / Q000276:immunology; D013950:Thymus Gland / Q000196:embryology / Q000276:immunology
D046911:Macromolecular Substances; D015345:Oligonucleotide Probes; D011948:Receptors, Antigen, T-Cell