title: [Renin-angiotensin and hypophyseo-adrenal systems in children suffering from congenital adrenocortical hyperplasia resulting from 21-hydroxylase deficiency].
abstract: A study was made of the activity of plasma renin (APR), and the blood levels of ACTH, 17-hydroxyprogesterone (17-OHP) and aldosterone (A) in 50 children suffering from congenital adrenocortical hyperplasia as a result of 21-hydroxylase deficiency; 38 girls and 12 boys aged 1.5 mos. to 14 years were divided into 2 groups: (1) 35 with a salt losing type of disease; (2) 15 with a common virile type of disease. ARP in the 1st group did not exceed the control values and was unaccompanied by adequate secretion of A. Moderate ARP in parallel with a high level of A was noted in the 2nd group. Mineral corticoid therapy resulted in reduced ARP and A concentration, and a tendency to a decrease in the levels of ACTH and 17-OHP was noted. Variations in ARP and in the level of A did not manifest themselves clinically and were unaccompanied by electrolytic disorders. In the authors' opinion, a choice of adequate therapy for both types of disease must be based on the results of investigation of the above hormonal parameters.
authors.forename: E P
authors.initials: EP
authors.lastname: Kasatkina
authors.forename: A N
authors.initials: AN
authors.lastname: Tiul'pakov
authors.forename: G V
authors.initials: GV
authors.lastname: Ibragimova
authors.forename: N N
authors.initials: NN
authors.lastname: Litvinova
mesh_terms: D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000303:Adrenal Cortex Diseases / Q000201:enzymology*; D000312:Adrenal Hyperplasia, Congenital / Q000201:enzymology*; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000450:Aldosterone / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000097:blood; D007223:Infant; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*
chemical_list: D006908:Hydroxyprogesterones; D000450:Aldosterone; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D012083:Renin
vernacular_title: Renin-angiotenzinovaia i gipofizarno-nadpochechnikovaia sistemy u deteĭ, stradaiushchikh vrozhdennoĭ giperplazieĭ kory nadpochechnikov vsledstvie defitsita 21-gidroksilazy.