Experimental Porphyromonas gingivalis infection in nonimmune athymic BALB/c mice.
The purpose of this report was to study the role of T lymphocytes following injection of Porphyromonas gingivalis in a mouse abscess model. Three invasive P. gingivalis isolates (ATCC 53977, W83, and AJW4) were injected into athymic BALB/c mice and their heterozygous (nu/+) littermates. The athymic BALB/c (nu/nu) mice were able to localize the invasive P. gingivalis isolates at the injection site. By comparison, the heterozygous BALB/c (nu/+) littermates developed hemorrhagic secondary lesions within 24 h after subcutaneous injection of the same invasive P. gingivalis isolates. These results suggest that naive T lymphocytes may contribute to the pathology associated with P. gingivalis infection.
Chen
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PB
Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo 14214.
Davern
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LB
Aguirre
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A
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D001442:Bacteroides Infections / Q000276:immunology* / Q000473:pathology; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D016966:Porphyromonas gingivalis; D013601:T-Lymphocytes / Q000276:immunology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G