[Changes in the myeloperoxidase and acid phosphatase activities in human peripheral blood neutrophils with the cells stimulated in vitro].
In four series of experiments human peripheral blood neutrophils were found capable of synthetizing the active forms of such enzymes as myeloperoxidase and acid phosphatase after stimulation with opsonized zymosan, and the optimum conditions for testing the synthetizing activity of neutrophils were established. The examination of 39 practically healthy donors revealed an approximate equilibrium between the synthesis of the active forms of the enzyme and its excretion from the cell after this cell was activated. Considerable changes in the enzymatic activity of peripheral blood neutrophils were found in patients with yersiniosis, chronic herpes, chronic bronchitis and AIDS-associated complex. The possibility of a deficient enzymatic activity in some patients was suggested.
Buraia
T L
TL
Butakov
A A
AA
Drozhennikov
V A
VA
Nikulin
V N
VN
Pinegin
B V
BV
Iushchuk
N D
ND
D000386:AIDS-Related Complex / Q000201:enzymology; D000135:Acid Phosphatase / Q000097:blood* / Q000187:drug effects; D001782:Blood Donors; D001991:Bronchitis / Q000201:enzymology; D002478:Cells, Cultured / Q000187:drug effects / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D006561:Herpes Simplex / Q000201:enzymology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology*; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D009195:Peroxidase / Q000097:blood* / Q000187:drug effects; D012016:Reference Values; D013997:Time Factors; D015009:Yersinia Infections / Q000201:enzymology
D009195:Peroxidase; D000135:Acid Phosphatase
Izmenenie aktivnosti mieloperoksidazy i kisloĭ fosfatazy v neĭtrofilakh perifericheskoĭ krovi cheloveka pri stimuliatsii kletok in vitro.