title: Effect of dietary menhaden oil on normal growth and development and on ameliorating mucosal injury in rats.
abstract: We evaluated the effects of menhaden oil on growth and development of the small intestinal mucosa in growing rats and on the progression and resolution of methotrexate-induced mucosal injury in the rats. One study compared effects of diets containing 10% safflower oil(SO), 9% SO and 1% menhaden oil (MO), 10% MO, or 9% MO and 1% SO on mucosal growth and development for 125 d. In another study, animals fed the 10% MO or the 10% SO diet for 5 wk were subjected to subcutaneous methotrexate injections for 3 consecutive days. Feeding rats a diet containing large amounts of menhaden oil resulted in lower prostaglandin E2 and leukotriene B4 synthesis and lower sucrase activities. Indicators of mucosal mass after methotrexate-induced injury were significantly improved in both the jejunum and ileum at 3 and 10 d after methotrexate administration. Our data suggest that dietary menhaden oil stimulates mucosal regeneration after methotrexate-induced injury.
authors.affiliation: Department of Pediatrics, Creighton University School of Medicine, Omaha.
authors.forename: J A
authors.initials: JA
authors.lastname: Vanderhoof
authors.forename: D J
authors.initials: DJ
authors.lastname: Blackwood
authors.forename: H
authors.initials: H
authors.lastname: Mohammadpour
authors.forename: J H
authors.initials: JH
authors.lastname: Park
mesh_terms: D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D015232:Dinoprostone / Q000096:biosynthesis; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D007082:Ileum / Q000254:growth & development / Q000473:pathology; D007410:Intestinal Diseases / Q000139:chemically induced / Q000178:diet therapy* / Q000473:pathology; D007413:Intestinal Mucosa / Q000254:growth & development* / Q000378:metabolism / Q000473:pathology; D007583:Jejunum / Q000254:growth & development / Q000473:pathology; D007975:Leukotriene B4 / Q000096:biosynthesis; D008297:Male; D008727:Methotrexate; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012450:Safflower Oil / Q000008:administration & dosage / Q000494:pharmacology; D013393:Sucrase / Q000378:metabolism
chemical_list: D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; C033266:Menhaden oil; D007975:Leukotriene B4; D012450:Safflower Oil; D013393:Sucrase; D015232:Dinoprostone; D008727:Methotrexate