title: Granulocyte-specific monoclonal antibody technetium-99m-BW 250/183 and indium-111 oxine-labelled leucocyte scintigraphy in inflammatory bowel disease.
abstract: Thirty-three patients suspected of suffering from inflammatory bowel disease were studied. Autologous leucocytes were labelled with indium 111 oxine and re-injected simultaneously with 0.3-0.5 mg of technetium 99m granulocyte-specific monoclonal antibody BW 250/183. Two scans were obtained, the early scan 3-4 h postinjection (p.i.) and the late scan 18-24 h p.i. Using the endoscopy study as standard, the diagnostic accuracy of both agents was determined. Sensitivity, specificity and accuracy of 111In scans was 88.8%, 100.0% and 93.7% at 4 h and 94.7%, 100.0% and 96.9% at 24 h, respectively. Concerning the results using antibodies, the values were 61.1%, 100.0% and 78.1% at 4 h and 78.9%, 92.8% and 84.8% at 24 h, respectively. Segmental analysis showed concordance in 89.3% and 93.3% of the cases at 4 and 24 h, respectively. Though less sensitive and less accurate than scanning employing indium 111 leucocytes, BW 250/183 granulocyte-specific scintigraphy can be used for inflammatory bowel disease diagnosis and localization.
authors.affiliation: Servei de Medicina Nuclear, Hospital de Bellvitage, Barcelona, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Segarra
authors.forename: M
authors.initials: M
authors.lastname: Roca
authors.forename: C
authors.initials: C
authors.lastname: Baliellas
authors.forename: L
authors.initials: L
authors.lastname: Vilar
authors.forename: Y
authors.initials: Y
authors.lastname: Ricart
authors.forename: J
authors.initials: J
authors.lastname: Mora
authors.forename: R
authors.initials: R
authors.lastname: Puchal
authors.forename: J
authors.initials: J
authors.lastname: Martin-Comin
mesh_terms: D000328:Adult; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D007962:Leukocytes; D008297:Male; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011237:Predictive Value of Tests; D016719:Radioimmunodetection; D012680:Sensitivity and Specificity; D013670:Sodium Pertechnetate Tc 99m
chemical_list: D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline; D013670:Sodium Pertechnetate Tc 99m