The role of IL-10 in crossregulation of TH1 and TH2 responses.
The identification of helper T (TH)-cell subsets has greatly improved understanding of the regulation of immune effector functions. In addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by TH2 cells that inhibits TH1-cell function.
Mosmann
T R
TR
Dept of Immunology, University of Alberta, Edmonton, Canada.
Moore
K W
KW
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000917:Antibody Formation; D002450:Cell Communication; D016207:Cytokines / Q000378:metabolism; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000473:pathology; D016753:Interleukin-10; D007378:Interleukins / Q000502:physiology*; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D010272:Parasitic Diseases / Q000276:immunology; D012689:Sequence Homology, Nucleic Acid; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D016207:Cytokines; D007378:Interleukins; D016753:Interleukin-10