Induction of vascular smooth muscle bradykinin B1 receptors in vivo during antigen arthritis.
Antigen arthritis in rabbits was associated with induction of bradykinin B1 receptors in isolated aorta smooth muscle 24 h following intra-articular injection of antigen in sensitized animals. Control tissues developed responsiveness to desArg9-bradykinin or bradykinin during 3 h incubation, but failed to respond to either kinin at the beginning of experiments. Aorta from rabbits 24 h after induction of arthritis not only developed responsiveness to kinins more rapidly than controls, but also responded at the outset of experiments. Antigen arthritis was characterized by acute phase protein synthesis and joint swelling. This is the first demonstration of induction of smooth muscle responsiveness to desArg9-bradykinin during an immune complex disease.
Farmer
S G
SG
Nova Pharmaceutical Corporation, Baltimore, MD 21224-2788.
McMillan
B A
BA
Meeker
S N
SN
Burch
R M
RM
D000818:Animals; D000941:Antigens; D001011:Aorta / Q000187:drug effects; D001168:Arthritis / Q000378:metabolism*; D001920:Bradykinin / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D005337:Fibrin / Q000276:immunology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D010656:Phenylephrine / Q000494:pharmacology; D011817:Rabbits; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter / Q000378:metabolism*
D000941:Antigens; D018002:Receptors, Bradykinin; D017981:Receptors, Neurotransmitter; C024626:bradykinin, des-Arg(9)-; D010656:Phenylephrine; D005337:Fibrin; D001920:Bradykinin