[The sodium selenite inhibition of asbestos-induced carcinogenesis in Wistar rats].
Sodium selenite given in drinking water in a 4 ppm solution during the whole experiment was found to significantly inhibit pleural carcinogenesis induced in Wistar rats by intrapleural injection of chrysotile-asbestos powder (20 mg three times, monthly, in 0.5 ml of physiologic saline). Mesothelioma of the pleura was induced in 20.5%. However, chrysotile alone induced tumor in 43.8%. Sodium selenite failed to influence carcinogenesis in other sites. Possible mechanisms of sodium selenite action are discussed.
Stadnikova
N M
NM
Kleĭmenova
E V
EV
Grankina
E P
EP
Pylev
L N
LN
D000818:Animals; D017632:Asbestos, Serpentine / Q000008:administration & dosage / Q000633:toxicity*; D016009:Chi-Square Distribution; D004353:Drug Evaluation, Preclinical; D004391:Dust / Q000009:adverse effects; D005260:Female; D008297:Male; D010997:Pleural Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000008:administration & dosage*
D017632:Asbestos, Serpentine; D004391:Dust; D018038:Sodium Selenite
Tormozhenie natriia selenitom asbestovogo kantserogeneza u krys Vistar.