Human papillomavirus types and recurrent cervical warts in immunocompromised women.
Little is known about the host's immunological response to human papillomavirus (HPV) infection, which is an important co-factor in genital tract cancers. This study analyzed the HPV type in pre- and posttreatment tissues in immunocompromised women with cervical squamous intraepithelial lesions (SILs) that recurred after ablative therapy. The HPV type was the same in the pre- and posttreatment lesion in nine of 12 recurrent SILs in women immunocompromised because of AIDS or long-term immunosuppressive therapy. In an extension of a previous study, it was noted that a different HPV type was present in the posttreatment SIL when compared to the pretreatment lesion in 13 of 14 cases in immunocompetent women. These observations support the hypothesis that a type-specific resistance may develop after ablative treatment, preventing re-infection by the same HPV type in immunocompetent women.
Nuovo
G J
GJ
Department of Pathology, SUNY, Stony Brook.
Babury
R
R
Calayag
P T
PT
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D003218:Condylomata Acuminata / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D004273:DNA, Neoplasm / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D009693:Nucleic Acid Hybridization; D027383:Papillomaviridae / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
D004273:DNA, Neoplasm; D004279:DNA, Viral