title: Are bilateral tumours hereditary?
abstract: Early observations regarding the age of onset, the family history and the clinical pattern of presentation of Wilms' tumour patients have been used to support the two-hit model of carcinogenesis, and to infer the hereditary nature of the bilateral form of the disease. Recent observations drawn from follow-up studies of offspring of unilaterally affected patients cast serious doubts upon the claim that a bilateral tumour implies the presence of an inherited predisposing mutation.
authors.affiliation: Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyon, France.
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
authors.forename: G M
authors.initials: GM
authors.lastname: Lenoir
mesh_terms: D016162:Genes, Wilms Tumor / Q000235:genetics; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D009396:Wilms Tumor / Q000235:genetics* / Q000473:pathology