An ion-storage time-of-flight mass spectrometer for analysis of electrospray ions.
A preliminary design and implementation of a novel approach to electrospray-mass spectrometry are described. Based on a time-of-flight mass analysis, the instrument provides several important advantages for on-line mass analysis: 1, simplicity, ease of use and low manufacturing cost; 2, rapid scan speed, yielding quasi-instantaneous full mass scans at repetition rates up to several kHz; 3, soft ionization and accurate mass determination of extremely large analyte molecules; 4, high sensitivity.
Boyle
J G
JG
Dept. of Chemical Engineering, Yale University, New Haven, CT 06520.
Whitehouse
C M
CM
Fenn
J B
JB
D001120:Arginine / Q000737:chemistry; D016572:Cyclosporine / Q000737:chemistry; D003574:Cytochrome c Group / Q000737:chemistry; D013058:Mass Spectrometry / Q000295:instrumentation*; D008970:Molecular Weight
D003574:Cytochrome c Group; D016572:Cyclosporine; D001120:Arginine