title: Tests of opioid deficiency hypotheses of alcoholism.
abstract: Eighty-three male rats were maintained on a daily regimen involving 22 h of deprivation of fluids followed by 2 h of access to water and a sweetened alcoholic beverage (12% ethanol, 5% sucrose). After about 3 weeks of such a regimen, rats eventually take considerable amounts of ethanol daily. In the present study, a series of injections of opioids was given subsequent to establishing stable daily intakes of ethanol. Specifically, before a day's opportunity to take fluids, some rats were given a small dose of morphine (2.0 mg/kg), while others were given a dose of naloxone (4.0 mg/kg). When morphine was given 0.5 h before the opportunity to drink, intake of ethanol was increased. However, when morphine was given 4.0 h before the opportunity, intake of ethanol was decreased. Nearly opposite effects were observed when naloxone was given. Other experiments tested the effects of giving morphine 4.0 h before the opportunity to drink plus the effects of a small dose of naloxone or plus the effects of a small dose of morphine. Morphine given 4.0 h before potentiated the effects of a small dose of naloxone and attenuated the effects of another dose of morphine. The effects of morphine were also shown to be similar among rats taking a solution of ethanol and water rather than a sweetened solution. These data provide support for the idea that surfeits, not deficits, in opioidergic activity increase propensity to take alcoholic beverages.
authors.affiliation: Department of Psychology, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.
authors.forename: L D
authors.initials: LD
authors.lastname: Reid
authors.forename: J D
authors.initials: JD
authors.lastname: Delconte
authors.forename: M L
authors.initials: ML
authors.lastname: Nichols
authors.forename: E J
authors.initials: EJ
authors.lastname: Bilsky
authors.forename: C L
authors.initials: CL
authors.lastname: Hubbell
mesh_terms: D000428:Alcohol Drinking; D000437:Alcoholism / Q000209:etiology*; D000704:Analysis of Variance; D000818:Animals; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*
chemical_list: D011957:Receptors, Opioid; D009270:Naloxone; D009020:Morphine