title: Primary cutaneous pleomorphic T-cell lymphoma expressing CD30 antigen.
abstract: Pleomorphic peripheral T-cell lymphomas (PPTL) arising primarily in the skin are uncommon. The observation of pleomorphic T-cell lymphoma composed of 100% CD30+ cells is rare. We report the case of a woman in whom such a tumor manifested itself with a single cutaneous lesion. It was composed of medium to large cells expressing markers of helper/inducer T-lymphocytes, as well as activation (CD30) and proliferation antigens (Ki-67), but not the CD25 activation antigen. The lesion was excised and the patient is alive and disease free 2 years after the diagnosis. This case confirms previous reports about the favorable course of some cutaneous pleomorphic lymphomas, and shows that the activation antigen expression and proliferation antigen (Ki-67) expression do not seem to worsen the prognosis.
authors.affiliation: First Clinic of Dermatology, University of Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Gianotti
authors.forename: E
authors.initials: E
authors.lastname: Alessi
authors.forename: S
authors.initials: S
authors.lastname: Cavicchini
authors.forename: E
authors.initials: E
authors.lastname: Berti
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D017730:Ki-1 Antigen; D019394:Ki-67 Antigen; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D016410:Lymphoma, T-Cell, Cutaneous / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen; D019394:Ki-67 Antigen; D009687:Nuclear Proteins