The involvement of polymorphonuclear leukocytes in the pathogenesis of bronchopneumonia in calves. IV. Myeloperoxidase activity.
Stable oxidant and hypochlorous acid production in neutrophils of bronchopneumonic calves was investigated. The production of these compounds was much more intense in neutrophils of diseased calves than in the control cells. The production of stable oxidants and hypochlorous acid was restrained by free radical scavengers. Functional response of neutrophils was inhibited by cyclooxygenase products and stimulated by lipoxygenase products of the arachidonic acid cascade. Superoxide anion production is not connected with the degranulation process (beta-glucuronidase release), and the two events are under different control mechanisms.
Ledwozyw
A
A
Department of Pathophysiology, Veterinary Faculty, Agricultural Academy, Lublin, Poland.
Stolarczyk
H
H
D000818:Animals; D001996:Bronchopneumonia / Q000209:etiology / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D016166:Free Radical Scavengers; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism*; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism*
D016166:Free Radical Scavengers; D009195:Peroxidase