title: Assignment of a human serum glycoprotein SP-40,40 gene (CLI) to chromosome 8.
abstract: SP-40,40 is a serum glycoprotein consisting of two different subunits (alpha and beta) assembled into a dimer by disulfide bonds. Northern blot hybridization, using total RNA from several cell lines, showed that SP-40,40 is expressed in glioblastoma and testicular tumor cells, as well as hepatoma cells. Spot blot hybridization of flow-sorted human chromosomes, using a SP-40,40 cDNA fragment as a probe, localized the gene for SP-40,40 to human chromosome 8. This gene has been given the designation CLI, for complement lysis inhibitor, by the Human Gene Nomenclature Committee.
authors.affiliation: Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tobe
authors.forename: S
authors.initials: S
authors.lastname: Minoshima
authors.forename: S
authors.initials: S
authors.lastname: Yamase
authors.forename: N H
authors.initials: NH
authors.lastname: Choi
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D001798:Blood Proteins / Q000235:genetics*; D015152:Blotting, Northern; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D051152:Clusterin; D005134:Eye Neoplasms / Q000235:genetics; D005434:Flow Cytometry; D015870:Gene Expression / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics; D008297:Male; D018832:Molecular Chaperones; D012175:Retinoblastoma / Q000235:genetics; D013736:Testicular Neoplasms / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D001798:Blood Proteins; C495242:CLU protein, human; D051152:Clusterin; D006023:Glycoproteins; D018832:Molecular Chaperones