Radioprotection of lethally irradiated animals: formulation and correlations.
Disparities in survival of mice and rats after lethal (LD100/30) radiation are resolved using two parameters: 1. total elapsed time (TET), defined as time interval between radioprotector administration to end of irradiation; and 2. area under the curve (AUC) of selected biochemical effects. The AUC from cytochrome oxidase inhibition by KCN, and TET, predict survivals of KCN-treated animals under different experimental conditions.
Schubert
J
J
Department of Biochemistry, Michigan State University, East Lansing 48824-1319.
D000818:Animals; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D011190:Potassium Cyanide / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000401:mortality / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000201:enzymology; D015996:Survival Rate
D011837:Radiation-Protective Agents; D003576:Electron Transport Complex IV; D011190:Potassium Cyanide