Effect of (+/-)-DOI on neuromuscular transmission: a microelectrode study.
DOI (1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) significantly depressed end plate current (EPC) amplitude. It decreased quantum content, increased the extent of neurally evoked EPC rundown during the train, produced a nonlinear current-voltage relationship, shortened time constant of decay, and depressed iontophoretically evoked EPC. The depressant response of DOI on EPC amplitude was antagonized by 5-HT1-like receptor antagonists, but was resistant to 5-HT2 and 5-HT3 receptor antagonists. This suggests that inhibitory 5-HT receptors roughly correspond to 5-HT1-like receptors.
Bhattacharyya
B J
BJ
Department of Anesthesia, College of Medicine, University of Iowa, Iowa City 52242.
Sokoll
M D
MD
Long
J P
JP
D000662:Amphetamines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D003864:Depression, Chemical; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D008839:Microelectrodes; D009469:Neuromuscular Junction / Q000502:physiology*; D011894:Rana pipiens; D011985:Receptors, Serotonin / Q000187:drug effects; D012702:Serotonin Antagonists; D009435:Synaptic Transmission / Q000187:drug effects*
D000662:Amphetamines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C015952:4-iodo-2,5-dimethoxyphenylisopropylamine