Signal transduction in yeast mating: receptors, transcription factors, and the kinase connection.
In the yeast Saccharomyces cerevisiae, peptide mating pheromones activate a signal transduction pathway that leads to cellular differentiation and cell division cycle arrest. It is now possible to trace the major events of this pathway. binding of pheromone to G-protein-coupled receptors activates a cascade of serine/threonine protein kinases that ultimately phosphorylate and increase the activity of an identified transcription factor.
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Institute of Molecular Biology, University of Oregon, Eugene 97403.
D002453:Cell Cycle / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D000072235:Mating Factor; D010455:Peptides / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology; D051964:Receptors, Mating Factor; D018000:Receptors, Peptide; D012098:Reproduction; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D010455:Peptides; D011956:Receptors, Cell Surface; D051964:Receptors, Mating Factor; D018000:Receptors, Peptide; D014157:Transcription Factors; D000072235:Mating Factor; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D019204:GTP-Binding Proteins