[Effect of ammonium perchlorate on calcium currents in neurons and leukocyte mobility].
NH4ClO4 has been studied for its effect on the voltage-activated calcium current (ICa) in voltage-clamp experiments on intracellularly perfused snail neurons and on the chemokinesis of rat leukocytes. It has been found that NH4ClO4 enhances ICa amplitude 1.5-5 times (EC50 = 3 mmol/l), decreases the rate of ICa decay and stimulates mobility of leukocytes 3 times (EC50 = 2.5 mmol/l). It is suggested that these changes may be intermediated by similar mechanisms, e.g. by an increase in intracellular pH.
Degtiar'
V E
VE
Kondrashova
L N
LN
D000818:Animals; D015220:Calcium Channels / Q000187:drug effects*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006372:Helix, Snails; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D010472:Perchlorates / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D051381:Rats
D015220:Calcium Channels; D010472:Perchlorates; D000644:Quaternary Ammonium Compounds; C053506:ammonium perchlorate
Vliianie perkhlorata ammoniia na kal'tsievye toki v neĭronakh podvizhnost' leĭkotsitov.