title: [In vitro immunization of human lymphocytes with Epstein-Barr virus capsid antigen].
abstract: Conditions for in vitro immunization of human lymphocytes from adult peripheral blood, tonsils and cord blood with Epstein-Barr Virus (EBV) capsid antigens have been studied. Pokeweed mitogen and B cell growth factor from Namalva cell line were shown to induce a significant production of specific antibodies by human lymphocytes stimulated with EBV. This effect made it possible to generate primary immune response in vitro using lymphocytes from EBV seronegative donors.
authors.forename: V V
authors.initials: VV
authors.lastname: Kulikov
authors.forename: A V
authors.initials: AV
authors.lastname: Krivonos
authors.forename: M E
authors.initials: ME
authors.lastname: Krasheninnikov
authors.forename: O V
authors.initials: OV
authors.lastname: Borisova
authors.forename: S L
authors.initials: SL
authors.lastname: Kal'nov
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000276:immunology*; D002213:Capsid / Q000276:immunology*; D003470:Culture Media; D005312:Fetal Blood / Q000166:cytology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007114:Immunization; D066298:In Vitro Techniques; D007231:Infant, Newborn; D008214:Lymphocytes / Q000276:immunology*; D014066:Palatine Tonsil / Q000166:cytology*
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D003470:Culture Media
vernacular_title: Immunizatsiia in vitro limfotsitov cheloveka kapsidnymi antigenami virusa Epshteĭna-Barr.