title: Contribution of immunohistochemistry in the diagnosis of neuroendocrine neoplasms of the larynx.
abstract: This chapter illustrates the use of mono- and polyclonal antibodies as diagnostic tools for neuroendocrine neoplasms of the larynx on the basis of data from the literature and the authors' personal experience. It is suggested that a panel of antibodies should be adopted, rather than to rely on the specificity and sensitivity of a single marker. It is also emphasized that immunohistochemical methods should serve not as a substitute but as a useful adjuvant in evaluating the morphological criteria of these neoplasms.
authors.affiliation: Department of Otolaryngology, University of Padua, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ferlito
authors.forename: I
authors.initials: I
authors.lastname: Friedmann
mesh_terms: D000911:Antibodies, Monoclonal; D002276:Carcinoid Tumor / Q000175:diagnosis*; D018288:Carcinoma, Small Cell / Q000175:diagnosis*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis*; D007830:Larynx / Q000737:chemistry; D010235:Paraganglioma / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D000911:Antibodies, Monoclonal