Prolonged stimulation of SH-SY5Y cells with carbachol inhibits inositol 1,4,5-trisphosphate (InsP3) binding and InsP3-induced Ca2+ mobilisation.
Wojcikiewicz
R J
RJ
Department of Pharmacology and Therapeutics, University of Leicester, U.K.
Nahorski
S R
SR
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels; D002217:Carbachol / Q000494:pharmacology*; D002460:Cell Line; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism* / Q000494:pharmacology; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007700:Kinetics; D009116:Muscarine / Q000494:pharmacology; D009474:Neurons; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology
D015220:Calcium Channels; D053496:Inositol 1,4,5-Trisphosphate Receptors; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D011976:Receptors, Muscarinic; D001285:Atropine; D009116:Muscarine; D015544:Inositol 1,4,5-Trisphosphate; D002217:Carbachol; D002118:Calcium