Cytochrome P450IIE1 metabolism of pyridines: evidence for production of a reactive intermediate which exhibits redox-cycling activity and causes DNA damage.
Kim
S G
SG
Institute of Chemical Toxicology, Wayne State University, Detroit, MI 48201.
Novak
R F
RF
D000818:Animals; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004249:DNA Damage; D005978:Glutathione / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D011725:Pyridines / Q000378:metabolism* / Q000633:toxicity; D011817:Rabbits; D013481:Superoxides / Q000378:metabolism
D011725:Pyridines; D013481:Superoxides; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D010089:Oxidoreductases, N-Demethylating; D005978:Glutathione