Cryptic variants of acrocentric human chromosomes as analysed by restriction endonucleases.
Ten phenotypically normal human individuals have been analysed by in situ treatments with restriction endonucleases in order to obtain a better characterization of some cryptic variants of acrocentric chromosomes. Treatments with AluI, NdeII and Sau3AI confirm the existence of two cryptic amplified regions on the short arms of both one chromosome 15 and one chromosome 22, in one female. These amplifications seem to be of different origin involving the nucleolar organizer region of chromosome 15 and the satellite of chromosome 22.
De Cabo
S F
SF
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
Ludeña
P
P
Velázquez
M
M
Sentis
C
C
Fernández-Piqueras
J
J
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002884:Chromosomes, Human, Pair 15; D002892:Chromosomes, Human, Pair 22; D004262:DNA Restriction Enzymes / Q000378:metabolism*; D004276:DNA, Satellite / Q000378:metabolism; D005260:Female; D006801:Humans; D005810:Multigene Family; D009697:Nucleolus Organizer Region / Q000378:metabolism; D010641:Phenotype
D004276:DNA, Satellite; D004262:DNA Restriction Enzymes