title: An unexpected rise in plasma aldosterone to furosemide-upright test in primary aldosteronism due to aldosterone producing adenoma.
abstract: This paper documents an unexpected rise in plasma aldosterone concentration (PAC) to the furosemide-upright test despite a decrease in adrenocorticotropin (ACTH) by dexamethasone, and an unresponsiveness in plasma renin activity to this stimulus in a patient with aldosterone producing adenoma. Furthermore, this patient showed an appropriate response in PAC to a rapid ACTH test, and an insensitivity in PAC to angiotensin-II (Ang-II) infusion. Other factor(s) besides ACTH or Ang-II may play a role in the plasma aldosterone response to ambulation after intravenous furosemide administration in patients with primary aldosteronism.
authors.affiliation: First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Shigemasa
authors.forename: T
authors.initials: T
authors.lastname: Kouchi
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Mashiba
mesh_terms: D000236:Adenoma / Q000097:blood* / Q000150:complications; D000310:Adrenal Gland Neoplasms / Q000097:blood* / Q000150:complications; D000324:Adrenocorticotropic Hormone / Q000502:physiology; D000328:Adult; D000450:Aldosterone / Q000097:blood*; D005665:Furosemide; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood* / Q000209:etiology; D008297:Male; D011187:Posture
chemical_list: D000450:Aldosterone; D005665:Furosemide; D000324:Adrenocorticotropic Hormone