Age-related acute depletion of cerebral glutathione by peroxidative stress.
Cyclohexene-1-one and cycloheptene-1-one cause a severe age-related depletion of reduced glutathione (GSH) in the forebrain of 5- or 15- or 25-month-old rats. Chronic pretreatment with phosphatidylcholine partially inhibits the GSH depletion in old forebrains by the prooxidants tested, suggesting that in aged animals alterations in mitochondrial inner membrane phospholipid composition and/or cytochrome oxidase activity might play a role in oxygen free-radical production.
Benzi
G
G
Institute of Pharmacology, University of Pavia, Italy.
Curti
D
D
Marzatico
F
F
Pastoris
O
O
D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D003508:Cycloheptanes / Q000494:pharmacology*; D003512:Cyclohexanones / Q000494:pharmacology*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism*; D008297:Male; D008959:Models, Neurological; D016877:Oxidants / Q000494:pharmacology*; D010713:Phosphatidylcholines / Q000494:pharmacology*; D016548:Prosencephalon / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D003508:Cycloheptanes; D003512:Cyclohexanones; D005609:Free Radicals; D016877:Oxidants; D010713:Phosphatidylcholines; C028215:2-cyclohexen-1-one; D003576:Electron Transport Complex IV; D005978:Glutathione