Human responses to inhaled capsaicin are not inhibited by granisetron.
Cough is a common respiratory symptom, the mechanism of which is poorly understood. In this study the role of 5-HT3 receptors was investigated. Capsaicin-induced cough and increase in airways resistance were measured in six male volunteers before and after infusion with granisetron 160 micrograms kg-1 or placebo. Neither cough nor the increase in respiratory resistance was altered by the active treatment. These results suggest that 5-HT3 receptors are not involved in these two respiratory responses to inhaled capsaicin in humans.
Choudry
N B
NB
Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
McEwan
J R
JR
Lavender
E A
EA
Williams
A J
AJ
Fuller
R W
RW
D000280:Administration, Inhalation; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D002211:Capsaicin / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003371:Cough / Q000503:physiopathology; D017829:Granisetron; D006801:Humans; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D012018:Reflex / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*
D002211:Capsaicin; D017829:Granisetron; D007191:Indazoles; D012702:Serotonin Antagonists