The synthesis and pharmacological activity of two new derivatives of benzazocine.
Two new derivatives of benzazocine of anticipated analgesic action were synthesized. Pharmacological investigations were carried out to confirm their analgesic activity, affinity to the opiate receptor and potential antagonistic properties.
Gutkowska
B
B
Department of Chemical Technology of Drugs, Medical Academy, Warszawa, Poland.
Gumułka
S W
SW
Krzaścik
P
P
Poppe
I
I
Mészáros
J
J
Makulska
H E
HE
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009292:Narcotic Antagonists / Q000494:pharmacology; D010423:Pentazocine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism; D013055:Spectrophotometry, Infrared
D000700:Analgesics; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D010423:Pentazocine