title: 5-Fluorouracil, etoposide, and cisplatin in the management of metastatic non-small cell lung cancer.
abstract: Encouraging response rates have been reported in Stage III non-small cell lung cancer when 5-fluorouracil (5-FU), etoposide (VP-16), and cisplatin (FED) have been combined with radiation therapy (RT) or RT and surgery. The current study evaluated the effectiveness of FED chemotherapy in 32 patients with metastatic non-small cell lung cancer. Treatment consisted of 5-FU (800 mg/m2/d) on days 1 to 4 by continuous infusion, intravenous (IV) VP-16 (60 mg/m2) over 1 hour on days 1 to 4, and IV cisplatin (60 mg/m2) over 1 hour on day 1. Treatment cycles were repeated every 28 days as toxicity permitted. Partial responses occurred in 7 of 32 patients (22%; 95% confidence limit [CL] 0.09, 0.40), including 6 of 19 patients (32%) with performance status of 0 or 1, and 1 of 13 patients (8%) with performance status of 2 or 3. The median response duration was 5.0 months. Although toxicity was modest and consisted of primarily hematologic and gastrointestinal side effects, this combination does not appear to provide an advantage over other cisplatin combinations in Stage IV non-small cell lung cancer.
authors.affiliation: Wayne State University/Harper-Grace Hospitals, School of Medicine, Division of Hematology and Oncology, Detroit, Michigan 48202-0188.
authors.forename: L
authors.initials: L
authors.lastname: Flaherty
authors.forename: A
authors.initials: A
authors.lastname: Wozniak
authors.forename: B
authors.initials: B
authors.lastname: Redman
authors.forename: M
authors.initials: M
authors.lastname: Kraut
authors.forename: S
authors.initials: S
authors.lastname: Martino
authors.forename: L
authors.initials: L
authors.lastname: Heilbrun
authors.forename: M
authors.initials: M
authors.lastname: Valdivieso
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000139:chemically induced; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity; D005047:Etoposide / Q000008:administration & dosage / Q000633:toxicity; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000633:toxicity; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D005047:Etoposide; D002945:Cisplatin; D005472:Fluorouracil