Hyposensitization therapy of Parietaria-sensitive patients with a tyrosine adsorbed allergoid, Pollinex Parietaria (Bencard Parietaria).
Thirty patients suffering from allergy to Parietaria pollen were treated with either a new tyrosine-adsorbed allergoid of Parietaria judaica pollen (Pollinex Parietaria) or a commercially available alum-adsorbed extract (Alavac) as control. A reduced response to nasal provocation was seen in 7 out of 11 patients following treatment with Pollinex and 1 out of 10 after control treatment. 9 out of 11 and 3 out of 10, respectively, showed reduced skin test activity. Patients who received Pollinex tended to have fewer nasal symptoms during the pollen season. Pollinex induced larger increases in P. judaica-specific IgG antibody than did the control product. Side effects of therapy were similar between the two groups of patients. Pollinex Parietaria thus shows good potential for the control of allergy to Parietaria pollen.
Bonifazi
F
F
Servizio Allergologia Respiratoria, Ospedale Generale Umberto I, Ancona, Italy.
Antonicelli
L
L
Bilò
M B
MB
Pucci
S
S
Taylor
I H
IH
Wheeler
A W
AW
Youlten
L J
LJ
D000328:Adult; D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology / Q000302:isolation & purification; D000080384:Allergoids; D052179:Antigens, Plant / Q000627:therapeutic use; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods*; D004338:Drug Combinations; D005260:Female; D005976:Glutaral / Q000008:administration & dosage / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007163:Immunosorbent Techniques; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage / Q000276:immunology; D010940:Plant Proteins / Q000008:administration & dosage / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D014443:Tyrosine / Q000008:administration & dosage / Q000276:immunology
D000485:Allergens; D000080384:Allergoids; D052179:Antigens, Plant; D004338:Drug Combinations; D007074:Immunoglobulin G; C083860:Par j I protein, Parietaria judaica; D010936:Plant Extracts; D010940:Plant Proteins; D014443:Tyrosine; C014155:Parietaria judaica pollen; D005976:Glutaral