[The immediate results of the combined chemotherapy of disseminated forms and recurrences of cervix uteri cancer with vincristine, platidiam and adriamycin].
Thirty patients with advanced or recurrent cervical cancer were given combination chemotherapy including 1 mg/m2 vincristine i. v. on days 1 and 8, 120 mg/m2 i. v. drop-wise on day 2 with hydration and forced diuresis and 40 mg/m2 adriamycin on day 9. Treatment courses were repeated every 3-4 weeks. Complete response was observed in 1 (3.3%) patient, while more than 50% regression of tumor was obtained in 12 (40%) patients raising the complete plus partial response rate to as high as 43.3%. Nausea and vomiting occurred in all the patients, myelosuppression--60%, nephrotoxic effect--44% and alopecia--in 96.7% of patients.
Zabunov
A V
AV
Dudareva
L A
LA
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009367:Neoplasm Staging; D012074:Remission Induction; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects
D014750:Vincristine; D004317:Doxorubicin; D002945:Cisplatin
Neposredstvennye rezul'taty kombinirovannoĭ khimioterapii rasprostranennykh form i retsidivov raka sheĭki matki vinkristinom, platidiamom i adriamitsinom.