title: Infection and reactivation with cytomegalovirus strains in lung transplant recipients.
abstract: Cytomegalovirus pneumonia is a major cause of morbidity and death following lung transplantation (LT) (1). The case fatality rate is highest in the CMV-seronegative recipients (R-) of organs from seropositive donors (D+), which suggests that transmission of CMV may occur with the graft (1), but in seropositive recipients (R+) the comparative importance of reactivation of endogenous virus and reinfection with donor virus is poorly understood.
authors.affiliation: Department of Medicine, Addenbrooke's Hospital, Cambridge, England.
authors.forename: R L
authors.initials: RL
authors.lastname: Smyth
authors.forename: J
authors.initials: J
authors.lastname: Sinclair
authors.forename: J P
authors.initials: JP
authors.lastname: Scott
authors.forename: J J
authors.initials: JJ
authors.lastname: Gray
authors.forename: T W
authors.initials: TW
authors.lastname: Higenbottam
authors.forename: T G
authors.initials: TG
authors.lastname: Wreghitt
authors.forename: J
authors.initials: J
authors.lastname: Wallwork
authors.forename: L K
authors.initials: LK
authors.lastname: Borysiewicz
mesh_terms: D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000209:etiology*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D011014:Pneumonia / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D014775:Virus Activation