The role of neuronal calcium channels in dependence on ethanol and other sedatives/hypnotics.
This review discusses the importance of neuronal calcium currents in dependence on ethanol, barbiturates, benzodiazepines and opiates. The main sections describe the actions of ethanol on control of intracellular calcium and on calcium and calcium-dependent conductance mechanisms. In particular, the effects of both acute and chronic ethanol treatment on dihydropyridine-sensitive, voltage-dependent, calcium channels are described. The later sections cover the effects of barbiturates, benzodiazepines and opiates on these systems. The conclusions suggest that dihydropyridine calcium channel antagonists may offer a new therapeutic approach to the treatment of ethanol and opiate dependence.
Little
H J
HJ
Pharmacology Department, Medical School, University Walk, Bristol, U.K.
D000437:Alcoholism / Q000188:drug therapy; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D001665:Binding Sites; D015220:Calcium Channels / Q000187:drug effects*; D004095:Dihydropyridines / Q000627:therapeutic use; D000431:Ethanol / Q000633:toxicity*; D006801:Humans; D009294:Narcotics / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects
D001463:Barbiturates; D015220:Calcium Channels; D004095:Dihydropyridines; D009294:Narcotics; D001569:Benzodiazepines; D000431:Ethanol; C038806:1,4-dihydropyridine