Effects of alprazolam on T-cell immunosuppressive response to surgical stress in mice.
Mice submitted to surgical stress induced by laparotomy and treated with chronic alprazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, as well as in peripheral T lymphocyte population. The blastic response of spleen lymphoid cells was also assessed and found to partially supress the inhibitory effect of surgery.
Freire-Garabal
M
M
Department of Pharmacology, Faculty of Medicine, University of Santiago de Compostela, Spain.
Belmonte
A
A
Orallo
F
F
Couceiro
J
J
Núñez
M J
MJ
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000525:Alprazolam / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001772:Blood Cell Count; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013312:Stress, Physiological / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects
D000324:Adrenocorticotropic Hormone; D000525:Alprazolam