title: [Application of a trans-membrane migration method in the study of human sperm motility: a review].
abstract: Transmembrane migration method is a bioassay specifically designed to study drug effect on human sperm motility. It was first used in the study of sperm immobilizing agents which have a membrane stabilizing effect. Then it was used to investigate the relationship between calcium ion and sperm motility. Recently, this method has been used to screen drugs that stimulate sperm motility. It has also been modified for the study of porcine sperm motility. Computer assisted semen analysis showed that the transmembrane migration method is most suitable for studying drug effect on rapid and straight-forward motility of sperm.
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming Medical College.
authors.forename: C Y
authors.initials: CY
authors.lastname: Hong
mesh_terms: D001681:Biological Assay / Q000379:methods; D002118:Calcium / Q000378:metabolism; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D013078:Sperm Immobilizing Agents / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects / Q000378:metabolism
chemical_list: D008567:Membranes, Artificial; D013078:Sperm Immobilizing Agents; D002118:Calcium