[7-ethoxycoumarin o-deethylase and fibrosis in chronic liver diseases].
In the liver biopsy of 100 patients with chronic liver diseases, the activity of 7-ethoxycoumarin O-deethylase (ECOD) was determined as a parameter of hepatic monooxygenase system and was compared with some markers of fibrosis e.g. collagen peptidase and hydroxyproline. ECOD was significantly different in healthy liver, fatty liver, chronic active hepatitis (CAH) and cirrhosis. The importance of the fibrotic process was shown by the significant correlations between ECOD and the signs of fibrosis in the liver biopsy. A connection between ECOD and the markers of fibrosis was not found. Further research is necessary to clarify this difference.
Truckenbrodt
J
J
Gastroenterologische Abteilung, Bereichs Medizin der Friedrich-Schiller-Universität Jena.
Müller
A
A
Kraul
H
H
Machnik
G
G
Volland
R
R
Reinhardt
M
M
Hoffmann
A
A
D015660:7-Alkoxycoumarin O-Dealkylase / Q000032:analysis*; D000328:Adult; D001711:Biotransformation; D002908:Chronic Disease; D005234:Fatty Liver / Q000201:enzymology; D005260:Female; D006521:Hepatitis, Chronic / Q000201:enzymology; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000201:enzymology*; D008103:Liver Cirrhosis / Q000201:enzymology*; D008297:Male; D003012:Microbial Collagenase / Q000032:analysis; D008875:Middle Aged
D015660:7-Alkoxycoumarin O-Dealkylase; D003012:Microbial Collagenase; D006909:Hydroxyproline
Die 7-Ethoxycoumarin O-Deethylase und der fibrosierende Prozess bei chronischen Lebererkrankungen.