Active human herpesvirus-6 (HHV-6) infection associated with Kikuchi-Fujimoto disease and systemic lupus erythematosus (SLE).
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) is a well defined disorder primarily affecting young adults. The cause of this disease is still unknown. The authors report a case of a 37-yar old woman with Kikuchi-Fujimoto disease and systemic lupus erythematosus (SLE). Serologic testing for HHV-6 antibodies revealed an active infection. An excised cervical lymph node contained HHV-6 genome demonstrated by using in situ hybridization. Active HHV-6 infection should be considered in Kikuchi-Fujimoto disease.
Hoffmann
A
A
Second Clinic of Internal Medicine, University of Cologne, F.R.G.
Kirn
E
E
Kuerten
A
A
Sander
C
C
Krueger
G R
GR
Ablashi
D V
DV
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D015654:Herpesvirus 6, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008199:Lymphadenitis / Q000150:complications* / Q000473:pathology
D000914:Antibodies, Viral; D015342:DNA Probes; D004279:DNA, Viral