[Inherited metabolic aberration of phenylalanine in the family members of patients with essential hypertension and stroke].
L-2H-Leu, L-2H-Val, L-2H-Ile, L-2H-Phe, 14N-Lys were chosen for comparing their metabolic kinetic variables among those with prominent genetic predisposition of essential hypertension (FH*, 10 subjects), of stroke (FS*, 12 subjects) and those without (F-, 12 subjects) groups by gas chromatography-mass spectrometry. Results showed that only the metabolic kinetics of phenylalanine was dearranged: (1) The plasma pools of FH* and FS* groups were enlarged; (2) The turnover rate constant between plasma pool and cell pool of FH* was constricted; (3) The cell pool of FH* was larger, while the turnover rate constant was smaller than that of FS* group. The aberration of phenylalanine metabolism in essential hypertension and stroke might relate with hyperfunction of sympathetic nervous activity genetically. These diseases possibly belong to the category related to the inherited amino-acid metabolic aberration.
Zhao
G
G
D000328:Adult; D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000235:genetics* / Q000378:metabolism; D005192:Family Health; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010649:Phenylalanine / Q000378:metabolism*
D010649:Phenylalanine