title: Abnormal cortical appearances in pediatric renal allografts.
abstract: Renal cortical studies were performed in 19 children with renal transplants. There were 10 normal studies and 9 abnormal studies, 8 of which showed multiple large focal peripheral cortical defects. The following factors showed a positive correlation: (a) the ischemia time of the transplant kidney was significantly shorter in patients with normal studies; (b) cadaver grafts were more likely to have abnormal scan appearances than living related donor grafts; and (c) in four of the five patients with double renal arteries, the scans were abnormal in multiple sites. A possible pathophysiologic mechanism to explain these scan appearances is asymptomatic segmental graft infarction secondary to progressive vascular disease. These infarcts may be a long-term sequela of ischemic insult at the time of or prior to the insertion of the renal allograft.
authors.affiliation: Department of Nuclear Medicine, Prince of Wales Hospital, Sydney, Australia.
authors.forename: G D
authors.initials: GD
authors.lastname: Williams
authors.forename: M
authors.initials: M
authors.lastname: Rossleigh
authors.forename: A R
authors.initials: AR
authors.lastname: Rosenberg
authors.forename: G
authors.initials: G
authors.lastname: Kainer
authors.forename: E M
authors.initials: EM
authors.lastname: Hodson
authors.forename: R H
authors.initials: RH
authors.lastname: Farnsworth
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007672:Kidney Cortex / Q000000981:diagnostic imaging*; D016030:Kidney Transplantation / Q000473:pathology*; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014019:Tissue Donors
chemical_list: D015609:Organotechnetium Compounds; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer