Histometric studies on cellular infiltrates of tuberculin tests in patients with sarcoidosis.
The density and microanatomical location of CD4 and CD8 lymphocytes and of monocytes/macrophages at the site of a tuberculin test were measured in 13 patients with sarcoidosis, and the results were compared with those seen in a group of healthy controls. The cellular infiltrate was significantly reduced in the sarcoid subjects compared with the controls for all cell phenotypes studied; the ratio of CD4 positive:CD8 positive lymphocytes was significantly increased in the sarcoid group. Clinically negative reactions showed substantial numbers of infiltrating mononuclear cells, although not as great as in clinically apparent reactions. A clinically negative tuberculin reaction does not necessarily imply anergy to the test substance and should not be termed "negative".
Lowe
J G
JG
Department of Dermatology, Ninewells Hospital and Medical School, Dundee.
Gibbs
J H
JH
Potts
R C
RC
Stanford
J L
JL
Swanson Beck
J
J
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000276:immunology; D012507:Sarcoidosis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014373:Tuberculin / Q000276:immunology*; D014374:Tuberculin Test
D000942:Antigens, Bacterial; D015703:Antigens, CD; D014373:Tuberculin