Revascularisation of bone grafts in rats.
Revascularisation of syngeneic and allogeneic intramuscular bone grafts have been studied using radioactive microspheres to measure the ingrowth of blood vessels. New bone formation and resorption were measured by 85strontium uptake and by graft weight reduction. Revascularisation, and mineralisation rate were significantly higher in syngeneic grafts than in allogeneic grafts at two, three and six weeks after implantation. The syngeneic grafts lost weight faster indicating that the allogeneic grafts resorbed more slowly. The ingrowth of new vessels is impaired in allogeneic bone, and this probably inhibits the rate of bone formation and resorption of the grafts.
Kirkeby
O J
OJ
Institute for Surgical Research, University of Oslo, Norway.
D000704:Analysis of Variance; D000818:Animals; D001783:Blood Flow Velocity; D016025:Bone Transplantation / Q000000981:diagnostic imaging / Q000379:methods / Q000502:physiology; D001842:Bone and Bones / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000502:physiology; D002113:Calcification, Physiologic; D002565:Cerium Radioisotopes / Q000493:pharmacokinetics; D003097:Collateral Circulation; D007085:Ilium / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008863:Microspheres; D009929:Organ Size; D011877:Radionuclide Imaging; D051381:Rats; D011917:Rats, Inbred Lew; D017208:Rats, Wistar; D013326:Strontium Radioisotopes / Q000493:pharmacokinetics; D014654:Vascular Patency
D002565:Cerium Radioisotopes; D013326:Strontium Radioisotopes