Neuroendocrine carcinoma of the ampulla of vater. A case of absence of somatostatin in a vasoactive intestinal polypeptide-, bombesin-, and cholecystokinin-producing tumor.
A 31-year-old patient with a clinical picture of obstructive jaundice had surgical treatment, and a primary carcinoid of the ampulla of Vater (VA) was found. The tumor was studied with light microscopy, immunohistochemistry, and electron microscopy. The neoplasm had histopathologic and cytopathologic features similar to those encountered in typical neuroendocrine neoplasms. It is interesting that immunohistochemical techniques disclosed the presence of vasointestinal polypeptide, cholecystokinin, and bombesin; however, unlike most neuroendocrine neoplasms arising in VA, no somatostatin-immunoreactive cells were found.
Sanchez-Sosa
S
S
Departamento de Patologia, Instituto Nacional de la Nutricion, Salvador Zubiran, Tlalpan, Mexico.
Angeles Angeles
A
A
Orozco
H
H
Larriva-Sahd
J
J
D000328:Adult; D014670:Ampulla of Vater; D001839:Bombesin / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism; D003138:Common Bile Duct Neoplasms / Q000378:metabolism* / Q000473:pathology; D004700:Endocrine System Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009423:Nervous System Neoplasms / Q000378:metabolism* / Q000473:pathology; D013004:Somatostatin / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D002766:Cholecystokinin; D001839:Bombesin