Immunogenicity trial of inactivated hepatitis A virus vaccine in human volunteers.
An inactivated hepatitis A virus (HAV) vaccine was tested on a group of human adult volunteers. The vaccine was administered subcutaneously, and a control group received a placebo (aluminium hydroxide). The vaccine was found to be relatively well tolerated and non-reactogenic, and levels of anti-HAV were comparable to those in other studies.
Kusov YuYu
Institute of Poliomyelitis and Viral Encephalitides, Moscow State Medical Institute, USSR.
Elbert
L B
LB
Nelga
I V
IV
Grishina
G K
GK
Dunaevski
O A
OA
Kharin
N V
NV
Maslov YuN
Drozdov
S G
SG
Balayan
M S
MS
D000293:Adolescent; D000328:Adult; D000536:Aluminum Hydroxide; D005260:Female; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000096:biosynthesis*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014611:Vaccination / Q000009:adverse effects; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects / Q000276:immunology*
D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies; D014613:Vaccines, Attenuated; D014761:Viral Hepatitis Vaccines; D000536:Aluminum Hydroxide