PET study of carbon-11-PK 11195 binding to peripheral type benzodiazepine sites in glioblastoma: a case report.
The utility of the peripheral type benzodiazepine site ligand 11C-PK 11195, for imaging human glioma in conjunction with Positron Emission Tomography, relies on a high specific binding of the tracer to tumoral peripheral type benzodiazepines sites. In a patient with glioblastoma, we found that 11C-PK 11195 binding was two-fold higher in the tumor than in normal gray matter and that 30% of tumoral binding could be displaced by a large excess of unlabeled drug. These findings suggest that tumoral retention of the ligand is due, in part, to specific binding.
Pappata
S
S
INSERM U. 334 Service Hospitalier Frédéric Joliot, Paris, France.
Cornu
P
P
Samson
Y
Y
Prenant
C
C
Benavides
J
J
Scatton
B
B
Crouzel
C
C
Hauw
J J
JJ
Syrota
A
A
D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002250:Carbon Radioisotopes; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D007546:Isoquinolines; D008297:Male; D011963:Receptors, GABA-A / Q000032:analysis*; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D007546:Isoquinolines; D011963:Receptors, GABA-A; C037850:PK 11195