title: The long term prognostic significance of c-erbB-2 in primary breast cancer.
abstract: The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.
authors.affiliation: University Department of Surgery, Liverpool, UK.
authors.forename: J
authors.initials: J
authors.lastname: Winstanley
authors.forename: T
authors.initials: T
authors.lastname: Cooke
authors.forename: G D
authors.initials: GD
authors.lastname: Murray
authors.forename: A
authors.initials: A
authors.lastname: Platt-Higgins
authors.forename: W D
authors.initials: WD
authors.lastname: George
authors.forename: S
authors.initials: S
authors.lastname: Holt
authors.forename: M
authors.initials: M
authors.lastname: Myskov
authors.forename: A
authors.initials: A
authors.lastname: Spedding
authors.forename: B R
authors.initials: BR
authors.lastname: Barraclough
authors.forename: P S
authors.initials: PS
authors.lastname: Rudland
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D011519:Proto-Oncogenes; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen / Q000032:analysis; D013534:Survival
chemical_list: D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen