[The dynamics of intravascular thrombocyte aggregation in photodynamic exposure].
The alterations taking place in the microvessels of the rat mesentery and liver under a photodynamic effect, were studied. Excitation of a photosensitizer injected preliminarily in the organism led to aggregation of thrombocytes in the lumen of hepatic and mesenteric microvessels until a complete obturation of the lumen. The dependence of the thrombocyte aggregate size on the duration of the photodynamic effect had a linear character whereas the photodynamic effect depended on the dosage of the photosensitizer. The level of fluorescence from the surface of the liver was found to decrease from the beginning of the photodynamic effect and become stable in hemostasis.
Kozlov
V I
VI
Zaĭtsev
K T
KT
Terman
O A
OA
Banin
V V
VV
Barabash
R D
RD
D000818:Animals; D006414:Hematoporphyrin Photoradiation; D008099:Liver / Q000098:blood supply / Q000187:drug effects; D008643:Mesentery / Q000098:blood supply / Q000187:drug effects; D008833:Microcirculation / Q000187:drug effects; D008856:Microscopy, Fluorescence; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
Dinamika vnutrisosudistoĭ agregatsii trombotsitov pri fotodinamicheskom vozdeĭstvii.