Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity.
Melanostatin, a new antibiotic with melanin synthesis inhibitor activity, was isolated from the fermentation broth of Streptomyces clavifer No. N924-2. Its structure was determined by spectral analysis and degradation experiments. Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.
Ishihara
Y
Y
Bristol-Myers Squibb Research Institute, Tokyo, Japan.
Oka
M
M
Tsunakawa
M
M
Tomita
K
K
Hatori
M
M
Yamamoto
H
H
Kamei
H
H
Miyaki
T
T
Konishi
M
M
Oki
T
T
D002855:Chromatography, Thin Layer; D005285:Fermentation; D009075:MSH Release-Inhibiting Hormone / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008546:Melanoma, Experimental; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D012988:Soil Microbiology; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000145:classification* / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D014407:Tumor Cells, Cultured
D008543:Melanins; D009075:MSH Release-Inhibiting Hormone; D014442:Monophenol Monooxygenase