Cross-coupling of signal transduction pathways: zinc finger meets leucine zipper.
Cell proliferation and cellular differentiation are often thought of as opposing phenomena. The molecular mechanisms by which steroid, retinoid and thyroid hormones inhibit cellular proliferation and by which growth factors stimulate this process are poorly understood. We discuss recent evidence suggesting that these two signal transduction pathways converge through a process referred to as 'cross-coupling', which involves a possible interaction between steroid hormone receptors and the c-Jun oncoprotein.
Schüle
R
R
Howard Hughes Medical Institute, Gene Expression Laboratory, La Jolla, CA.
Evans
R M
RM
D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D000242:Cyclic AMP / Q000502:physiology; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006728:Hormones / Q000502:physiology*; D016350:Leucine Zippers / Q000502:physiology*; D008954:Models, Biological; D011487:Protein Conformation; D016760:Proto-Oncogene Proteins c-fos / Q000502:physiology; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000502:physiology; D012045:Regulatory Sequences, Nucleic Acid; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D014212:Tretinoin / Q000494:pharmacology; D016335:Zinc Fingers / Q000502:physiology*
D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D005938:Glucocorticoids; D006133:Growth Substances; D006728:Hormones; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D011956:Receptors, Cell Surface; D011965:Receptors, Glucocorticoid; D014157:Transcription Factors; D014212:Tretinoin; D000242:Cyclic AMP