Establishment and characterization of a bi-phenotypic leukemic cell line, NALM-19, from a patient with acute leukemia.
Based on the immunophenotypic and genotypic findings, this acute leukemia cell line, designated NALM-19, is unique in that a partial expression of both B-cell and myeloid cell features are present in this single clonal leukemic cell population. It is noteworthy that two "normal" EB virus-transformed B cell lines, B239 and B240, (paired with NALM-19) were established from the same leukemic blood.
Matsuo
Y
Y
Department of Internal Medicine, Okayama City Hospital.
Ariyasu
T
T
Adachi
T
T
Tsubota
T
T
Imanishi
J
J
Minowada
J
J
D000208:Acute Disease; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D015139:Blotting, Southern; D002455:Cell Division; D002472:Cell Transformation, Viral; D004273:DNA, Neoplasm / Q000032:analysis; D004854:Herpesvirus 4, Human; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008297:Male; D010641:Phenotype; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D004273:DNA, Neoplasm