Effects of alternate routes of epinephrine delivery in experimental bradycardia-hypotension.
The magnitude and rapidity of response to epinephrine given by various routes were evaluated using a new model of bradycardia and hypotension. In ten animals, left ventricular (LV) injection of 10 micrograms/kg of epinephrine was superior to right ventricular (RV) injection in regard to time to attain a 20% increase in heart rate (HR), a 10% increase in mean arterial pressure (MAP) and time to reach peak MAP, although the peak MAP itself did not significantly differ. Similar results occurred with a 15 micrograms/kg dose. Aortic injection in seven of the animals resulted in a much longer time to target HR, an equal time to target MAP and a longer time to peak MAP compared to LV injection. LV injection of epinephrine results in a significantly more rapid onset of action than RV injection in the bradycardic, hypotensive animal. Epinephrine's beneficial effect appears to be derived from its vasoconstrictive, chronotropic and inotropic properties.
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Department of Medicine, Montefiore University Hospital, Pittsburgh, PA 15213.
Jetty
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Michelson
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Schneider
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D000818:Animals; D001011:Aorta; D001919:Bradycardia / Q000188:drug therapy; D004285:Dogs; D004837:Epinephrine / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006323:Heart Arrest / Q000188:drug therapy*; D006352:Heart Ventricles; D007022:Hypotension / Q000188:drug therapy; D007267:Injections; D007269:Injections, Intra-Arterial; D012151:Resuscitation; D013997:Time Factors
D004837:Epinephrine