Transcriptional control of vitamin D-regulated proteins.
Vitamin D is a physiological regulator of gene transcription associated with control of a broad spectrum of biological processes that include but is not restricted to growth, differentiation and calcium-mediated homeostatic control. Transcriptional regulation is mediated by sequence-specific interactions of a 1,25(OH)2D3-vitamin D receptor-accessory factor complex with vitamin D responsive elements (VDRE) residing in the promoters of hormone responsive genes. Functioning primarily as a transcription enhancer, activity at the VDRE is controlled by diverse and integrated cellular signalling pathways acting synergistically and/or antagonistically with a series of basal regulatory elements and other hormone regulated sequences that are components of modularly organized vitamin D-responsive gene promoters. Molecular mechanisms that integrate the activities at promoter elements contributing to vitamin D-related transcriptional control include overlapping transcription factor binding domains within regulatory elements and cooperative activities at independent regulatory sequences that determine the level of vitamin D responsiveness.
Lian
J B
JB
Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655.
Stein
G S
GS
D000818:Animals; D001483:Base Sequence; D004247:DNA; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic; D014807:Vitamin D / Q000502:physiology*
D011506:Proteins; D014807:Vitamin D; D004247:DNA