Secretory granule and synaptic vesicle formation.
Sorting of secreted proteins into dense-core secretory granules may involve selective aggregation of regulated secretory proteins, rather than a conventional sortase. Synaptic vesicles, which mediate paracrine communication between adjacent cells, appear to arise by a modification of the early endosome pathway. Targeting to the cell surface involves the actin-based cytoskeleton and small GTP-binding proteins.
Kelly
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RB
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.
D000818:Animals; D001048:Aplysia / Q000378:metabolism; D002450:Cell Communication; D002451:Cell Compartmentation; D002478:Cells, Cultured; D016798:Ciliophora / Q000502:physiology; D003594:Cytoplasmic Granules / Q000378:metabolism*; D003599:Cytoskeleton / Q000502:physiology; D005089:Exocytosis; D019204:GTP-Binding Proteins / Q000502:physiology; D008561:Membrane Fusion; D008563:Membrane Lipids / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D010743:Phospholipids / Q000502:physiology; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D013572:Synaptic Vesicles / Q000378:metabolism*
D008563:Membrane Lipids; D008565:Membrane Proteins; D010743:Phospholipids; D011506:Proteins; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins