Regulation of NGF gene expression in CNS glia by cell-cell contact.
Nerve growth factor (NGF) gene expression in central nervous system (CNS) glia appears to be associated with active glial growth. To study the underlying molecular mechanisms, we examined the effects of a number of growth-related factors on NGF mRNA expression in glial cultures. Our results suggest that glial membrane interaction, as a consequence of growth, actively inhibits NGF gene expression in CNS glia.
Lu
B
B
Department of Neurology, Cornell University of Medical College, New York, NY 10021.
Lee
J M
JM
Elliott
R
R
Dreyfus
C F
CF
Adler
J E
JE
Black
I B
IB
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000502:physiology*; D002450:Cell Communication; D002455:Cell Division; D002462:Cell Membrane / Q000502:physiology; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000502:physiology*; D009414:Nerve Growth Factors / Q000235:genetics*; D009457:Neuroglia / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D013116:Spinal Cord / Q000502:physiology*
D009414:Nerve Growth Factors; D012333:RNA, Messenger