title: Proton-coupled solute transport in the animal cell plasma membrane.
abstract: This review focuses primarily on the progress made in the last couple of years in the understanding of the intestinal peptide transporter, a prototype for H(+)-coupled solute transport systems in the animal cell plasma membrane. The impressive number of transport systems currently known to be energized by the components of the proton-motive force indicates that the role of H+ as the coupling ion for active transport has not been lost during evolution.
authors.affiliation: Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912.
authors.forename: V
authors.initials: V
authors.lastname: Ganapathy
authors.forename: F H
authors.initials: FH
authors.lastname: Leibach
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000828:Animal Population Groups / Q000378:metabolism; D000818:Animals; D001693:Biological Transport, Active; D015820:Cadherins; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004151:Dipeptides / Q000378:metabolism; D004734:Energy Metabolism; D006859:Hydrogen / Q000378:metabolism; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D026901:Membrane Transport Proteins; D008871:Microvilli / Q000378:metabolism; D008969:Molecular Sequence Data; D010455:Peptides / Q000378:metabolism*; D011522:Protons; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344 / Q000378:metabolism; D013045:Species Specificity
chemical_list: D015820:Cadherins; D002352:Carrier Proteins; C490586:Cdh17 protein, rat; D004151:Dipeptides; D026901:Membrane Transport Proteins; D010455:Peptides; D011522:Protons; C067802:intestinal peptide-proton cotransporter; C004194:glycylsarcosine; D006859:Hydrogen; D000255:Adenosine Triphosphate