title: [Clinico-morphological signs of hormone-producing ovarian tumors].
abstract: Apparent signs of hormonal activity were observed in 65.3% of patients with hormone-producing ovarian tumors of different histology. Feminization was evident in 69.1% of cases of granulosa-stromal cell tumors: it was most often seen in patients with mixed theca-granulosa cell tumors (86.2%) but was least frequent in those with Brenner's tumor (22.2%). The occurrence of proliferative lesions of the uterus such as hyperplasia of the endometrium, cervical canal polyps and uterine myoma (81.8%) was higher in patients with granulosa-stromal cell tumors, too, the highest rate being observed for cases of mixed theca-granulosa cell tumors (93.1%) whereas the lowest--for patients with Brenner's tumor (27.8%). Various clinical signs of masculinization were most often seen in cases of androblastoma (79.2%) whereas the proliferative disorders in that group were rare (12.5%). As a result, the authors placed mixed theca-granulosa cell, theca cell, granulosa cell tumors and Brenner's tumor in the order of decreasing feminizing activity. In the granulosa-stromal cell tumor subgroup, masculinization was most often observed in granulosa cell tumor patients (12.1%).
authors.forename: R T
authors.initials: RT
authors.lastname: Adamian
mesh_terms: D001948:Brenner Tumor / Q000378:metabolism* / Q000473:pathology; D004714:Endometrial Hyperplasia / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006106:Granulosa Cell Tumor / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D010053:Ovary / Q000473:pathology; D011127:Polyps / Q000209:etiology; D018310:Sertoli-Leydig Cell Tumor / Q000378:metabolism* / Q000473:pathology; D013798:Thecoma / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology; D014594:Uterine Neoplasms / Q000209:etiology
chemical_list: D012739:Gonadal Steroid Hormones
vernacular_title: Kliniko-morfologicheskie proiavleniia pri gormonprodutsiruiushchikh opukholiakh iachnikov.