Mycotoxic peripheral myelinopathy, myopathy, and hepatitis caused by Diplodia maydis in vervet monkeys.
During recent historical times many Africans changed their diet to one based on maize. The grain is regularly contaminated by fungi which are toxigenic to domestic animals and birds. After one of the fungi, Diplodia maydis, in pure culture on maize, was added to the food of omnivorous primates there was demyelination of nerves, atrophy, degeneration and necrosis of muscle, and hepatitis. These preliminary results are applicable to veterinary and laboratory animal sciences. They may also be medically significant since neuromuscular syndromes of unknown cause are prevalent among Africans. Nerve conduction velocities and organ weights are defined for vervet monkeys.
Fincham
J E
JE
Research Instiute for Nutritional Diseases, South African Medical Research Council, Tygerberg.
Hewlett
R
R
de Graaf
A S
AS
Taljaard
J J
JJ
Steytler
J G
JG
Rabie
C J
CJ
Seier
J V
JV
Venter
F S
FS
Woodroof
C W
CW
Wynchank
S
S
D000818:Animals; D001284:Atrophy; D001798:Blood Proteins / Q000032:analysis; D002522:Chlorocebus aethiops; D004798:Enzymes / Q000097:blood; D005260:Female; D005516:Food Microbiology; D006520:Hepatitis, Animal / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D003904:Mitosporic Fungi; D008992:Monkey Diseases / Q000382:microbiology* / Q000503:physiopathology; D009135:Muscular Diseases / Q000382:microbiology / Q000503:physiopathology / Q000662:veterinary; D009181:Mycoses / Q000382:microbiology / Q000503:physiopathology / Q000662:veterinary*; D009186:Myelin Sheath / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009431:Neural Conduction; D009929:Organ Size; D010525:Peripheral Nerves / Q000648:ultrastructure; D010523:Peripheral Nervous System Diseases / Q000382:microbiology / Q000503:physiopathology / Q000662:veterinary; D003313:Zea mays
D001798:Blood Proteins; D004798:Enzymes