[Alpha-tocopherol protects beta-adrenoreceptors of the rat brain from damaging effects of phospholipase A2].
The effect of synaptosomal membrane phospholipid hydrolysis by phospholipase A2 and alpha-tocopherol upon the state of beta-adrenergic receptors has been studied. The damaging action of phospholipase A2 on beta-adrenergic receptors, consisting in the decrease of specific binding of 3H-dihydroalprenolol at the expense of diminishing receptor affinity and Bmax was demonstrated. It was shown, that alpha-tocopherol protects beta-adrenergic receptors from damaging effect of phospholipase A2.
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D000818:Animals; D001921:Brain / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*; D014810:Vitamin E / Q000494:pharmacology*
D011943:Receptors, Adrenergic, beta; D014810:Vitamin E; D010741:Phospholipases A; D054467:Phospholipases A2
alfa-tokoferol zashchishchaet beta-adrenoretseptory mozga krys ot povrezhdaiushchego deĭstviia fosfolipazy A2.