title: Echocardiographic contrast imaging of the human right heart: a multicenter study of the efficacy, safety, and reproducibility of intravenous SHU-454.
abstract: The contrast agent SHU-454 was intravenously injected in 103 patients during echocardiography: 37 mL/patient +/- 7 ml/patient. The quality of the contrast effect was optimal in 13, good in 51, sufficient in 30, and poor in 9 patients; reproducibility was optimal in 38, good in 46, sufficient in 17, and poor in 2 patients. Taste sensation, arm discomfort, or atypical chest pain occurred in 5 patients, premature ventricular contractions in 3. An isolated anginal attack occurred in 1 patient with frequent episodes at rest. A slight reduction in hematologic indices was attributed to hemodilution. Thus, SHU-454 produces a good and reproducible contrast effect with tolerable side effects.
authors.affiliation: CNR, Clinical Physiology Institute, Pisa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Rovai
authors.forename: M
authors.initials: M
authors.lastname: Lombardi
authors.forename: G
authors.initials: G
authors.lastname: Cini
authors.forename: M A
authors.initials: MA
authors.lastname: Morales
authors.forename: M
authors.initials: M
authors.lastname: Colonna
authors.forename: G
authors.initials: G
authors.lastname: Bechelli
authors.forename: P
authors.initials: P
authors.lastname: Marino
authors.forename: L
authors.initials: L
authors.lastname: Zanolla
authors.forename: M A
authors.initials: MA
authors.lastname: Prioli
authors.forename: G L
authors.initials: GL
authors.lastname: Nicolosi
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects; D004452:Echocardiography; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000008:administration & dosage / Q000009:adverse effects; D015203:Reproducibility of Results
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C040642:SHU 454