Methodological issues in drug-drug conditioning in rats: nonassociative factors in heart rate and avfail.
Sodium pentobarbital injections followed 30 min later by d-amphetamine sulfate produce an effect over trials in the form of an increase in heart rate in response to pentobarbital in relation to rats that receive the 2 drugs 24 hr apart (long-delayed control: Revusky, Davey, & Zagorski, 1989). This study found equivalent increases in heart rate in forward and backward groups in relation to a long-delayed control regardless of whether training or testing was carried out in a heart rate recording apparatus or in the home cage, which suggests that a drug interaction due to drug administrations in forward and backward groups has yet to be eliminated in accounting for the heart rate effect. Comparison of backward and long-delayed controls in a drug-drug procedure that used a taste aversion test revealed that both forward and delayed pairings can produce attenuated aversions in relation to a backward group regardless of whether the unconditional stimulus is amphetamine (Experiment 1) or lithium chloride (Experiment 2).
Davey
V A
VA
Division of Life Sciences, University of Toronto, Scarborough, Canada.
Biederman
G B
GB
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D006706:Homeostasis / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects; D013649:Taste / Q000187:drug effects
D002712:Chlorides; D008094:Lithium; D018021:Lithium Chloride; D010424:Pentobarbital; D003913:Dextroamphetamine