title: Effects of neonatal gamma-ray irradiation on rat hippocampus--II. Development of excitatory amino acid binding sites.
abstract: In the rat, neonatal irradiation produces a destruction of dentate granule cells and prevents the development of the mossy fibre-CA3 pyramidal cell synapse. The developmental increase of high affinity kainate binding sites in the stratum lucidum was reduced on the irradiated side as compared with the control side. This suggests that a proportion of high affinity kainate binding sites is associated with mossy fibres. In contrast, the developmental profile of N-methyl-D-aspartate binding sites, which are associated with associational and commissural synapses in CA3, was not affected by irradiation. The role that afferent fibres may play in the development of pyramidal cells is discussed in connection with the modulatory effects of glutamate receptors on the development of neurons.
authors.affiliation: INSERM U29, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Dessi
authors.forename: A
authors.initials: A
authors.lastname: Represa
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Ari
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001345:Autoradiography; D005720:Gamma Rays; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism / Q000528:radiation effects*; D009474:Neurons / Q000502:physiology / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface / Q000378:metabolism / Q000528:radiation effects*; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism
chemical_list: D017459:Receptors, Amino Acid; D011956:Receptors, Cell Surface; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter