title: [Anti-idiotypic antibodies to the herpes simplex type-1 virus neutralize the virus' infectious activity].
abstract: Immunochemical study of blood sera from mice immunized with rabbit immunoglobulins (AT1) to herpes simplex virus type I (HSV-I) detected antiidiotypic antibodies AT2 in five of them (antiID). The affinity-purified antiID were shown to induce in syngeneic mice production of antibody (AT3) interacting with HSV-I antigen. In vitro, antiID (AT3) were shown to neutralize the virus activity. Analysis of the results suggests that the antiID imitate the antigenic properties of HSV-I and can induce specific immune response.
authors.forename: A A
authors.initials: AA
authors.lastname: Kushch
authors.forename: T A
authors.initials: TA
authors.lastname: Posevaia
authors.forename: V I
authors.initials: VI
authors.lastname: Simonov
authors.forename: O S
authors.initials: OS
authors.lastname: Daniliuk
authors.forename: I F
authors.initials: IF
authors.lastname: Barinskiĭ
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D002846:Chromatography, Affinity; D003168:Complement Fixation Tests; D007114:Immunization; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests / Q000379:methods; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral
vernacular_title: Antiidiotipicheskie antitela k virusu prostogo gerpesa tipa 1 neĭtralizuiut infektsionnuiu aktivnost' virusa.