[Possibility of ovulation induction using naloxone in women with hypothalamic amenorrhea].
Within the study we treated 6 women suffering from hypothalamic amenorrhea with 4 mg naloxone intravenous daily. The duration of the study was at most 30 days. The estimation of hormonal baseline and changes occurs daily, furthermore everyday sonographic folliculometry. In 2 patients the chronic opiate receptor blockade leads to a drastic stimulation of gonadotropin secretion. One of these women (responder in Naloxone-Test) has a long standing elevation of LH and FSH resulting in an ovulation 2 days past end of the therapy. The other women (non-responder in Naloxone-Test) reaches a follicular growth till 17 mm follicle diameter following in preterm atresia during therapy. In another woman (minimal-responder in Naloxone-Test) occurs a short and weak elevation of gonadotropins without any basic stimulation of the hypothalamic-pituitary-ovary axis. The results of this study show that: 1. it's possible to discern an opioid mediated hypothalamic amenorrhea and 2. a Naloxone-Test or Naloxone-Stimulation-Test should be put before starting a therapy with opiate antagonists in hypothalamic amenorrhea.
Krause
B
B
Universitäts-Frauenklinik, Ernst-Moritz-Arndt-Universität Greifswald.
Möller
S
S
Göretzlehner
G
G
D000328:Adult; D000568:Amenorrhea / Q000503:physiopathology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction; D011957:Receptors, Opioid / Q000187:drug effects; D014463:Ultrasonography
D011957:Receptors, Opioid; D007987:Gonadotropin-Releasing Hormone; D009270:Naloxone
Untersuchungen zur Möglichkeit einer Ovulationsinduktion mittels Naloxon bei Frauen mit hypothalamischer Amenorrhoe.