Lipid peroxidation in fatty liver induced by caffeine in rats.
An increase in lipid peroxidation has been found in liver after poisoning with hepatotoxic substances and following dietary changes, i.e. choline-devoid diet and orotic acid-rich diet. In this study we analysed in the rat a model of fatty liver induced by administration of caffeine. The results seem to indicate an increased peroxidability in the liver of caffeine-treated animals, due to an increase in triglyceride content. A decrease of vitamin E which also occurs might contribute to the lipid peroxidation.
Dianzani
M U
MU
Department of Medicine and Experimental Oncology, University of Turin, Italy.
Muzio
G
G
Biocca
M E
ME
Canuto
R A
RA
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D002110:Caffeine; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014280:Triglycerides / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D014280:Triglycerides; D014810:Vitamin E; D002110:Caffeine; D015105:3',5'-Cyclic-AMP Phosphodiesterases