title: Morphological investigation of iron-induced epileptic rats: with special reference to c-fos immunohistochemistry and iron staining.
abstract: We investigated the iron-induced epileptic rats with special reference to c-fos immunohistochemistry and iron histochemistry in order to elucidate the pathogenesis of post-traumatic epilepsy. The c-fos-immunopositive neurons were observed in a hippocampal formation, especially in the dentate gyrus and CA1 and CA2, in the vicinity of the iron injected cerebral cortex and amygdala only at 3 hours after the iron administration. Three days later after administration, several heavily positively iron staining cells and nerve fibers were observed around the injection site. In the cases of 3 weeks after administration, the large cavity and gliosis were characteristically observed.
authors.affiliation: Department of Anatomy, Okayama University Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mizukawa
authors.forename: H
authors.initials: H
authors.lastname: Kabuto
authors.forename: A
authors.initials: A
authors.lastname: Mori
mesh_terms: D000679:Amygdala / Q000473:pathology; D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology; D004834:Epilepsy, Post-Traumatic / Q000473:pathology*; D005911:Gliosis / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D007124:Immunoenzyme Techniques; D007501:Iron / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000473:pathology; D016760:Proto-Oncogene Proteins c-fos / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D007501:Iron