Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.
The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.
Yu
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Department of Tumor Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Scorsone
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K
Hung
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MC
D017456:Adenovirus Early Proteins; D000818:Animals; D015139:Blotting, Southern; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D015870:Gene Expression; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000235:genetics; D009856:Oncogene Proteins, Viral / Q000502:physiology*; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases; D014162:Transfection
D017456:Adenovirus Early Proteins; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases