title: Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity.
abstract: Immunization with purified cardiac myosin induces autoimmune myocarditis in A strain mice. Because this disease parallels Coxsackievirus B3 (CB3)-induced myocarditis in many respects, we are now using the immunization model as a virus-free system to study certain forms of immunologically-mediated heart disease. In the present article we will describe several characteristics of the humoral and cellular autoimmune response acting in myosin-induced myocarditis. Furthermore, we discuss hypotheses which might explain how myosin-reactive T cells recognize and attack the heart tissue.
authors.affiliation: Institute for General and Experimental Pathology, Medical School, University of Innsbruck, Austria.
authors.forename: N
authors.initials: N
authors.lastname: Neu
authors.forename: R
authors.initials: R
authors.lastname: Klieber
authors.forename: M
authors.initials: M
authors.lastname: Frühwirth
authors.forename: P
authors.initials: P
authors.lastname: Berger
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D003384:Coxsackievirus Infections / Q000276:immunology; D004195:Disease Models, Animal; D029822:Enterovirus B, Human; D051379:Mice; D008815:Mice, Inbred Strains; D009205:Myocarditis / Q000276:immunology* / Q000382:microbiology; D009218:Myosins / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D009218:Myosins