Assignment of the gene coding for human cytochrome c oxidase subunit VIb to chromosome 19, band q13.1, by fluorescence in situ hybridisation.
A cloned, 40 kb, genomic DNA fragment, containing the last exon of the gene for human cytochrome c oxidase subunit VIb and its flanking sequences, was used as a probe to localize the subunit VIb gene on human metaphase chromosomes. The probe was labelled with Bio-11-dUTP and detected by fluorescence. Subsequent R-banding indicated that the cytochrome c oxidase subunit VIb gene is localized in band 19q13.1, extending the evidence that the human nuclear genes of cytochrome c oxidase are not clustered.
Taanman
J W
JW
Laboratory of Physiological Chemistry, University of Groningen, The Netherlands.
van der Veen
A Y
AY
Schrage
C
C
de Vries
H
H
Buys
C H
CH
D001710:Biotin; D015139:Blotting, Southern; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003576:Electron Transport Complex IV / Q000235:genetics*; D005453:Fluorescence; D015698:Genomic Library; D006801:Humans; D009693:Nucleic Acid Hybridization
D001710:Biotin; D003576:Electron Transport Complex IV