The effect of an oil formulation on the systemic availability of oxfendazole.
Pure oxfendazole (OFZ) suspended in peanut oil and the commercial formulation 'Synanthic' were each intraruminally administered to Merino weaners at 5 mg kg-1. Plasma was collected and concentrations of OFZ, fenbendazole (FBZ) and FBZ sulphone (FBZ.SO2) were determined by HPLC. The maximum concentrations and area under the plasma concentration curve (AUC) of OFZ and FBZ were significantly higher (P less than 0.05) when OFZ was suspended in peanut oil than when administered as the commercial formulation.
Ali
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CSIRO Division of Animal Health, McMaster Laboratory, New South Wales, Australia.
Chick
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D000818:Animals; D000871:Anthelmintics / Q000097:blood / Q000493:pharmacokinetics*; D010367:Arachis; D001562:Benzimidazoles / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D005273:Fenbendazole / Q000097:blood; D000074241:Peanut Oil; D010938:Plant Oils; D012756:Sheep / Q000378:metabolism*
D000871:Anthelmintics; D001562:Benzimidazoles; D000074241:Peanut Oil; D010938:Plant Oils; D005273:Fenbendazole; C011030:oxfendazole