title: Lipid peroxidation in fatty liver induced by caffeine in rats.
abstract: An increase in lipid peroxidation has been found in liver after poisoning with hepatotoxic substances and following dietary changes, i.e. choline-devoid diet and orotic acid-rich diet. In this study we analysed in the rat a model of fatty liver induced by administration of caffeine. The results seem to indicate an increased peroxidability in the liver of caffeine-treated animals, due to an increase in triglyceride content. A decrease of vitamin E which also occurs might contribute to the lipid peroxidation.
authors.affiliation: Department of Medicine and Experimental Oncology, University of Turin, Italy.
authors.forename: M U
authors.initials: MU
authors.lastname: Dianzani
authors.forename: G
authors.initials: G
authors.lastname: Muzio
authors.forename: M E
authors.initials: ME
authors.lastname: Biocca
authors.forename: R A
authors.initials: RA
authors.lastname: Canuto
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000818:Animals; D002110:Caffeine; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014280:Triglycerides / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
chemical_list: D014280:Triglycerides; D014810:Vitamin E; D002110:Caffeine; D015105:3',5'-Cyclic-AMP Phosphodiesterases