title: [AMP deaminase activity in hyperoxia and the effect of AMP on animal sensitivity to oxygen under pressure].
abstract: Under the effects of 0.7 MPa of oxygen leading to a convulsive state, AMP-deaminase activity increased significantly in the rat brain mitochondrial fraction with only a tendency to increase in cytoplasmic fraction. Stimulated effects of the enzyme allosteric activator ATP is more obvious in intact animals than in hyperoxic ones. Pretreatment with AMP before hyperoxygenation exerts a protective effect preventing the alteration of monoamine oxydase catalytic properties, stabilizing membrane structure and improving the general state of the animals.
authors.forename: I A
authors.initials: IA
authors.lastname: Goroshinskaia
authors.forename: Z G
authors.initials: ZG
authors.lastname: Bronovitskaia
mesh_terms: D000659:AMP Deaminase / Q000032:analysis / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000494:pharmacology*; D000818:Animals; D001273:Atmosphere Exposure Chambers; D001921:Brain / Q000201:enzymology; D003593:Cytoplasm / Q000201:enzymology; D004361:Drug Tolerance; D005260:Female; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D010100:Oxygen / Q000008:administration & dosage*; D051381:Rats; D012640:Seizures / Q000201:enzymology / Q000209:etiology
chemical_list: D000249:Adenosine Monophosphate; D000659:AMP Deaminase; D010100:Oxygen
vernacular_title: Aktivnost' AMF-dezaminazy pri giperoksii i vliianie AMF na chuvstvitel'nost' zhivotnykh k kislorodu pod davleniem.