title: Signal transduction during C. elegans vulval induction.
abstract: Nematode proteins related to the human epidermal growth factor receptor and Ras proteins act in a common pathway to control cell fates in response to an inductive signal. Analysis of these gene products during C. elegans vulval induction allows detailed study of their function in the context of a developing organism.
authors.affiliation: Howard Hughes Medical Institute, Division of Biology, Pasadena, CA.
authors.forename: P W
authors.initials: PW
authors.lastname: Sternberg
authors.forename: H R
authors.initials: HR
authors.lastname: Horvitz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002107:Caenorhabditis / Q000235:genetics / Q000254:growth & development*; D029742:Caenorhabditis elegans Proteins; D005260:Female; D019204:GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation; D005796:Genes; D005804:Genes, Lethal; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007814:Larva; D008969:Molecular Sequence Data; D009024:Morphogenesis; D005810:Multigene Family; D009928:Organ Specificity; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000502:physiology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D014844:Vulva / Q000254:growth & development; D018631:ras Proteins
chemical_list: D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; D011956:Receptors, Cell Surface; C066646:let-60 protein, C elegans; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); D018631:ras Proteins