Outcome of pregnancy after first trimester exposure to H2 receptor antagonists.
H2 antagonists are widely prescribed medications and are often consumed by women who are unaware of being pregnant. In 23 cases reported to the Motherisk program there were two spontaneous abortions, two therapeutic abortions, 18 normal births, and one infant with a large hemangioma of the upper right eyelid. The hemangioma was removed without incident. Our data suggest that cimetidine and ranitidine may not be teratogenic risk in humans.
Koren
G
G
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Zemlickis
D M
DM
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D002927:Cimetidine / Q000009:adverse effects; D005260:Female; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D009864:Ontario / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011899:Ranitidine / Q000009:adverse effects; D012307:Risk Factors
D006635:Histamine H2 Antagonists; D002927:Cimetidine; D011899:Ranitidine