Virus-associated haemophagocytic syndrome with Epstein-Barr virus infection.
The clinical and histological findings of a 10-year-old girl with virus-associated haemophagocytic syndrome are presented. The serum levels of Epstein-Barr viral antigens were elevated. Epstein-Barr virus (EBV) genome was detected by polymerase chain reaction in bone marrow and lymph node specimens. Histologically, haemophagocytic histiocytes were present in bone marrow, and areas of non-suppurative necrosis were present in lymph nodes, where silver grain deposition of the EBV genome was demonstrated by in situ hybridization.
Ohshima
K
K
Department of Pathology, School of Medicine, Fukuoka University, Japan.
Kikuchi
M
M
Eguchi
F
F
Kobari
S
S
Tasaka
H
H
D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D005293:Ferritins / Q000097:blood; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics; D006644:Histiocytes / Q000473:pathology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008969:Molecular Sequence Data; D009336:Necrosis; D009693:Nucleic Acid Hybridization; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology / Q000473:pathology*
D000956:Antigens, Viral; D005293:Ferritins