title: [Biological effect of human erythropoietin in transgenic mice].
abstract: Transgenic mice were obtained inheriting the human erythropoietin gene under the control of viral regulatory elements. The reliable difference in haematocrit, the content of haemoglobin and percentage of reticulocytes in peripheral blood were not revealed. The level of serum erythropoietin in transgenic mice is several fold higher than in control mice. The increased pool of erythroid cells was observed in the bone marrow of transgenic mice, especially of normoblasts (3-fold) and reticulocytes (4,5-fold).
authors.forename: N N
authors.initials: NN
authors.lastname: Mudrik
authors.forename: L G
authors.initials: LG
authors.lastname: Eshkind
authors.forename: T E
authors.initials: TE
authors.lastname: Manakova
authors.forename: E M
authors.initials: EM
authors.lastname: Karalova
authors.forename: D O
authors.initials: DO
authors.lastname: Abroian
authors.forename: V Z
authors.initials: VZ
authors.lastname: Tarantul
authors.forename: K G
authors.initials: KG
authors.lastname: Gazarian
mesh_terms: D000818:Animals; D001358:Avian Sarcoma Viruses / Q000235:genetics; D001772:Blood Cell Count; D015139:Blotting, Southern; D001854:Bone Marrow Cells; D004921:Erythropoietin / Q000032:analysis / Q000235:genetics* / Q000502:physiology; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D051379:Mice; D008822:Mice, Transgenic; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D006454:Hemoglobins; D004921:Erythropoietin
vernacular_title: Biologicheskiĭ éffekt éritropoétina cheloveka u transgennykh mysheĭ.