Blood pressure cosegregates with a microsatellite of angiotensin I converting enzyme (ACE) in F2 generation from a cross between original normotensive Wistar-Kyoto rat (WKY) and stroke-prone spontaneously hypertensive rat (SHRSP).
We investigated the linkage between high blood pressure and the ACE gene in the F2 generation between SHRSP/Izm and WKY/Izm. The male F2 rats were categorized into 3 genotypes according to a microsatellite polymorphism in the ACE gene. Significantly high blood pressure was observed in the SHRSP homozygotes when it was compared to the blood pressure of the heterozygotes. Further, after 2 or 3 months salt-loading, the blood pressure was significantly higher in the SHRSP homozygotes than in the heterozygotes and the WKY homozygotes. The heterozygotes had a blood pressure similar to that in the WKY homozygotes, indicating that the effect of the ACE gene genotype was recessive. Salt appetite was neither correlated with the salt-sensitivity nor cosegregated with the ACE genotype. The results indicate that the locus of ACE gene associates with the development of hypertension, especially salt-sensitive hypertension.
Nara
Y
Y
Department of Pathology, Shimane Medical University, Izumo, Japan.
Nabika
T
T
Ikeda
K
K
Sawamura
M
M
Endo
J
J
Yamori
Y
Y
D000818:Animals; D001066:Appetite; D001794:Blood Pressure; D003433:Crosses, Genetic; D016172:DNA Fingerprinting; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D005838:Genotype; D006720:Homozygote; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics*; D011921:Rats, Inbred WKY / Q000235:genetics*; D012982:Sodium, Dietary
D012982:Sodium, Dietary; D007703:Peptidyl-Dipeptidase A