[Biosynthesis of biogenic pyrimidines in anxiety and depressive states of different etiologies].
Biosynthesis of endogenous pyrimidines was investigated in 37 patients with anxiety, anxious-depressive, depressive and hypochondriac syndromes emerging in schizophrenia and manic-depressive psychosis against a control group of healthy subjects (n-20) andopiate abusers (n-10). It was found that depressive and anxiety states in the examinees were associated with inhibition of endogenous pyrimidines synthesis likely to result in abnormal depression and anxiety levels.
Karkishchenko
N N
NN
Stradomskiĭ
B V
BV
Makliakov
Iu S
IuS
Zaika
V G
VG
D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000209:etiology / Q000378:metabolism*; D001714:Bipolar Disorder / Q000150:complications / Q000378:metabolism / Q000523:psychology; D003866:Depressive Disorder / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D009963:Orotic Acid / Q000378:metabolism*; D012559:Schizophrenia / Q000150:complications / Q000378:metabolism; D012565:Schizophrenic Psychology; D014529:Uridine / Q000096:biosynthesis* / Q000097:blood
D009963:Orotic Acid; D014529:Uridine
Biosintez éndogennykh pirimidinov pri trevozhnykh i depressivnykh sostoianiiakh razlichnoĭ étiologii.