Hepatocellular carcinoma in Fanconi's anemia treated with androgen and corticosteroid.
The case of an 11-year-old boy is reported who was known to have Fanconi's anemia for 3 years and was treated with androgens, corticosteroids and transfusions. Two weeks before his death he was readmitted because of aplastic crisis with septicemia and marked abnormalities in liver function and died of hemorrhagic bronchopneumonia. At autopsy peliosis and multiple hepatic tumors were found which histologically proved to be well-differentiated hepatocellular carcinoma. This case contributes to the previous observations that non-metastasizing hepatic neoplasms and peliosis can develop in patients with androgen- and corticosteroid-treated Fanconi's anemia.
Moldvay
J
J
1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
Schaff
Z
Z
Lapis
K
K
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D000728:Androgens / Q000009:adverse effects / Q000627:therapeutic use*; D001803:Blood Transfusion; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000209:etiology*; D002648:Child; D005199:Fanconi Anemia / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D010382:Peliosis Hepatis / Q000139:chemically induced / Q000209:etiology; D011239:Prednisolone / Q000009:adverse effects / Q000627:therapeutic use; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000728:Androgens; D011239:Prednisolone; D011241:Prednisone