Prompt hydrolysis of adenosine 3', 5'-cyclic monophosphate by Co(III) complexes.
Adenosine 3',5'-cyclic phosphate (cAMP) is efficiently hydrolyzed at pH 7, 50 degrees C by use of [Co-(trien) (H2O)2]3+ and [Co(tme)2-(H2O)2]3+ complexes as catalysts: trien (diethylenetriamine) and tme (1,1,2,2-tetramethylethylenediamine). The acceleration is remarkable (10(8) to 10(9) fold), decreasing half-life of cAMP from 660,000 years to 7-15 hours.
Yonezawa
K
K
Institute of Materials Science, University of Tsukuba, Ibaraki, Japan.
Matsumoto
Y
Y
Komiyama
M
M
D003035:Cobalt / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism*; D006868:Hydrolysis; D007700:Kinetics; D015394:Molecular Structure
D003035:Cobalt; D000242:Cyclic AMP