[Is fluidization of the phospholipid bilayer by general anesthetics a reason for general anesthesia?].
It was found that chlorpromazine and pipolfene potentiating general anaesthesia increase viscosity of phospholipid membrane in the region of polar headgroups and in the hydrophobic area near glycerol sceleton. These results (independently of potentiating mechanism) confuse a mechanism of anaesthetics action as increased fluidity of membrane phospholipids.
Burt
A Iu
AIu
Abramov
Iu B
IuB
Sachkov
V I
VI
D000768:Anesthesia, General; D000777:Anesthetics / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D008051:Lipid Bilayers; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids; D010743:Phospholipids; D011398:Promethazine / Q000494:pharmacology
D000777:Anesthetics; D008051:Lipid Bilayers; D008563:Membrane Lipids; D010743:Phospholipids; D011398:Promethazine; D002746:Chlorpromazine
Iavliaetsia li indutsirovannoe obshchimi anestetikami razzhizhenie fosfolipidnogo bisloia prichinoĭ obshcheĭ anestezii?