[Characterization of an experimental model of monosodium- glutamate-induced convulsions in the amphibian Bufo spp].
In previous reports, Feria-Velasco et al. characterized an experimental model of convulsions in rats induced by monosodium glutamate (MSG) with evaluation of the motor behavior and neurochemical parameters. In the present work, MSG injected in toads (Bufo spp) reproduced the model of convulsions with some peculiarities. The electrocorticographic recordings in toads after MSG injection were similar to those obtained in rats after administration of convulsant agents. Most of the toads injected with MSG (81.8%) showed convulsions preceded by an episode of stereotyped movements and signs of hyperexcitability. Latency for convulsions and frequency of convulsive episodes were similar to what has been reported in rats injected with MSG. However, the duration of convulsive period was larger than that seen in rats, and no deaths were recorded in toads. The peculiar feature of amphibia regarding their cerebral structures and their blood-brain barrier (BBB) make the amphibian model, an interesting and valuable one in studying experimentally induced convulsions, as well as the role of BBB in these phenomena.
Alfaro
F
F
División de Patología Experimental, Unidad de Investigación Biomédica de Occidente, IMSS, Guadalajara, Jalisco, México.
Blas
O
O
Gutiérrez-Padilla
R
R
Feria-Velasco
A
A
D000818:Animals; D001812:Blood-Brain Barrier; D002025:Bufonidae; D003292:Convulsants / Q000633:toxicity*; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced; D005260:Female; D007272:Injections, Intralymphatic; D008297:Male; D012377:Rodentia; D012640:Seizures / Q000139:chemically induced*; D012970:Sodium Glutamate / Q000633:toxicity*; D013045:Species Specificity; D013226:Status Epilepticus / Q000139:chemically induced; D013239:Stereotyped Behavior / Q000187:drug effects
D003292:Convulsants; D012970:Sodium Glutamate
Caracterización de un modelo de convulsiones experimentalmente inducidas por glutamato monosódico en el anfibio Bufo spp.