Cardiac beta-adrenoceptor sensitivity and Parkinson's disease.
Certain clinical manifestations of Parkinson's disease (PD) (speech or/and balance disturbances) are not linked to brain dopamine deficiency. The purpose of the present study was to search for a possible relationship between those so-called "non-dopamine-dependent" extrapyramidal manifestations and the sensitivity of cardiac beta-adrenoceptors. Fourteen patients aged 51 to 69 were included in the study after having given their informed consent. Any factor or pathology susceptible to modify receptor sensitivity entailed exclusion. In the absence of a reference model for measuring the reactivity of central beta-adrenoceptors, a computation of the isoprenalin dose necessary to increase the resting heart rate by 20 bpm was used as an index for beta-adrenergic system reactivity. In addition to that test, other parameters were recorded: disease duration, motor status scale (Columbia), some cognitive functions (MMS and image differed recall). The cardiac beta-receptor decrease in reactivity to isoproterenol is correlated to PD duration (r = 0.8, P less than 0.001). Conversely, the sensitivity of these receptors appeared to be unrelated to the extrapyramidal severity of the disease, hence to the degree of the so-called "non dopamine-dependent" disturbances. Furthermore, such results raise the meaning of the impairment of peripheral aminergic receptors in the cognitive disturbances linked to ageing and/or PD.
Milon
D
D
Laboratoire de Pharmacologie expérimentale et clinique, CHR Pontchaillou, Rennes, France.
Allain
H
H
Bentue-Ferrer
D
D
Martinet
J P
JP
Lemaitre
M H
MH
Decombe
R
R
D000368:Aged; D000375:Aging; D001794:Blood Pressure / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry*; D010300:Parkinson Disease / Q000503:physiopathology*; D010891:Piribedil / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D011943:Receptors, Adrenergic, beta; D001971:Bromocriptine; D007980:Levodopa; D010891:Piribedil; D007545:Isoproterenol