title: Chromosome abnormalities in lymphocytes and fibroblasts of subjects with multiple endocrine neoplasia type 1.
abstract: A consistent degree of chromosome instability was found in cultured lymphocytes and in fibroblasts derived from skin biopsies of three patients with multiple endocrine neoplasia type 1 (MEN1). In both tissues, there was a significant increase in chromosomal breakage. Dicentrics and tricentrics, rings, translocations, deletions, acentric fragments, and presumptive double minutes were the most frequent abnormalities in lymphocytes. The fibroblasts of two patients had large clones consisting of trisomy 7 and trisomy 18 cells, respectively.
authors.affiliation: Biologia Generale e Genetica Medica, Università di Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Scappaticci
authors.forename: P
authors.initials: P
authors.lastname: Maraschio
authors.forename: N
authors.initials: N
authors.lastname: del Ciotto
authors.forename: G S
authors.initials: GS
authors.lastname: Fossati
authors.forename: A
authors.initials: A
authors.lastname: Zonta
authors.forename: M
authors.initials: M
authors.lastname: Fraccaro
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002873:Chromosome Fragility; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000235:genetics*