[The characteristics of the action of GABA-ergic agents on the brain microcirculation during motor activity and hypodynamia].
Changes in the microcirculatory bed of the rat brain cortex during motor activity and hypodynamia under the action of piracetam, GABA and bicuculline were studied. The possibility of the development of compensatory processes due to the cerebral blood flow increase under the influence of GABA agonists at a disturbance of the cerebral hemodynamics in combination with increased locomotor activity and also due to the improvement of the microcirculation at early stages of hypodynamia induced by administration of GABA agonists opens up new perspectives in the use of GABA-positive drugs.
Akopian
V P
VP
Balian
L S
LS
Melkonian
K V
KV
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001640:Bicuculline / Q000494:pharmacology; D002540:Cerebral Cortex / Q000098:blood supply / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000503:physiopathology; D007551:Isotonic Contraction / Q000187:drug effects; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000502:physiology; D012149:Restraint, Physical; D013550:Swimming; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D001640:Bicuculline; D010889:Piracetam
Ob osobennostiakh deĭstviia GAMK-ergicheskikh sredstv na mikrotsirkuliatsiiu mozga v usloviiakh dvigatel'noĭ aktivnosti i gipodinamii.