Possible sources of iron for lipid peroxidation.
Possible sources of iron for lipid peroxidation are described and discussed. In particular, evidence is presented that microsomes contain ferric nonheme iron which may participate in formation of lipid oxidants, provided reductants are available to favor its mobilization from membrane binding sites. Aging- and tumor-associated changes of this microsomal pool of nonheme iron are also described and discussed from biochemical and biomedical viewpoints.
Minotti
G
G
Institute of General Pathology, Catholic University School of Medicine, Rome, Italy.
Di Gennaro
M
M
D'Ugo
D
D
Granone
P
P
D000818:Animals; D002374:Catalase / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004317:Doxorubicin / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005293:Ferritins / Q000378:metabolism; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D007501:Iron / Q000378:metabolism*; D015227:Lipid Peroxidation; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D005609:Free Radicals; D006878:Hydroxides; D013481:Superoxides; D017665:Hydroxyl Radical; D004317:Doxorubicin; D005293:Ferritins; D003577:Cytochrome P-450 Enzyme System; D006861:Hydrogen Peroxide; D007501:Iron; D002374:Catalase; D013482:Superoxide Dismutase; D010634:Phenobarbital