Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme.
We have employed an immunohistochemical analysis to study the ras p21 oncoprotein in a total of 41 brain tumors and 1 reactive gliosis. The tumors included 33 astrocytomas, 1 oligodendroglioma, 2 ependymomas, 1 neurilemmoma, 1 malignant meningioma, 1 neuroblastoma and 2 medulloblastomas. Our results indicate that elevated ras p21 expression is a common feature in a range of brain tumors. In particular, elevated ras p21 expression has been found in 18 out of 24 high grade astrocytomas (malignant astrocytomas and glioblastomas multiforme) compared to 3 out of 9 low grade (well differentiated astrocytomas) (P less than 0.05). These results suggest that ras p21 expression may be an important molecular marker of the malignant astrocytomas and glioblastomas multiforme.
Arvanitis
D
D
Department of Pathology, Children's Hospital Aghia Sophia, Athens, Greece.
Malliri
A
A
Antoniou
D
D
Linardopoulos
S
S
Field
J K
JK
Spandidos
D A
DA
D001254:Astrocytoma / Q000737:chemistry*; D001932:Brain Neoplasms / Q000737:chemistry*; D015870:Gene Expression; D005909:Glioblastoma / Q000737:chemistry*; D006801:Humans; D007150:Immunohistochemistry; D016283:Proto-Oncogene Proteins p21(ras) / Q000032:analysis*
C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)