[Acute pancreatitis caused by sodium valproate. Review of the literature apropos of a case in a child].
The authors report on the case of a 12.5 and year-old epileptic boy with severe acute pancreatitis which appeared 39 months after starting treatment with sodium valproate (VAP) at a daily dosage of 26.6 mg/kg. Twelve days after hospitalization, a pseudocyst of the pancreas developed, leading to cystoduodenostomy 3 months later. Following VPA suppression, no recurrence of pancreatic symptomatology was observed. The pathophysiological mechanism of this adverse side-effect of VPA treatment remains unclear. The appearance of a painful epigastric syndrome and/or vomiting in a patient subjected to a VPA treatment indicates the possibility or acute pancreatitis, to be confirmed by blood and urinary determination of amylases and abdominal tomodensitometric examination. Finally, the fact that this side-effect may be severe even lethal, brings into question the prescription of this drug in the management of epilepsy.
Rose
E
E
Département d'anesthésie-réanimation, CHU de Brabois, Vandoeuvre-lès-Nancy, France.
de Miscault
G
G
Thome
M
M
Boussard
N
N
D000208:Acute Disease; D002648:Child; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced* / Q000503:physiopathology / Q000601:surgery; D011379:Prognosis; D014635:Valproic Acid / Q000009:adverse effects*
D014635:Valproic Acid
Pancréatite aiguë au valproate de sodium. Revue de la littérature à propos d'un cas chez l'enfant.