title: Toxicity of hydroxyapatite in vitro: the effect of particle size.
abstract: Finely ground powders of synthetic hydroxyapatite applied to fibroblasts in vitro reduced the total growth rate and mitotic rate of the cells and increased the number of pycnotic cells. The effect was dose related and only occurred with small particles. The small particles appear to either adhere to the cells or are phagocytosed by them and the toxic effect may be physical rather than chemical.
authors.affiliation: Department of Anatomy, University of Wales College, Cardiff, UK.
authors.forename: E J
authors.initials: EJ
authors.lastname: Evans
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002478:Cells, Cultured; D017886:Durapatite; D005347:Fibroblasts / Q000473:pathology; D006882:Hydroxyapatites / Q000633:toxicity*; D008938:Mitosis / Q000502:physiology; D010316:Particle Size; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D006882:Hydroxyapatites; D017886:Durapatite