title: [Synthesis and antibacterial activity of thiosemicarbazones of 3-acylquinolones].
abstract: Oxidation of 3-acetyl derivatives of 3-acetyl-1-ethyl-1,4-dihydro-6,7-methylenedioxyquinoline-4-one (VIc) and 3-acetyl-7-chloro-1-ethyl-6-fluoro-1,4-dihydroquinoline-4-one (VId) with selenium dioxide provided the corresponding acids, [1-ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxoquinoline-3-yl]glyoxylic acid (VIe) and [7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-yl]glyoxylic acid (VIf), respectively. Reactions of compounds VIc--VIf with thiosemicarbazide yielded the respective thiosemicarbazones of 3-acetyl-1-ethyl-1,4-dihydro-6,7-methylenedioxyquinoline-4-one (VIIa), 3-acetyl-7-chloro-1-ethyl-6-fluoro-1,4-dihydroquinoline-4-one (VIIb), [1-ethyl-1,4-dihydro-6,7-methylenedioxy-4-oxoquinoline-3-yl]glyoxylic acids (VIId). The compounds showed no significant in vitro antibacterial activity.
authors.affiliation: Výzkumný ústav pro farmacii a biochemii, Praha.
authors.forename: S
authors.initials: S
authors.lastname: Rádl
authors.forename: M
authors.initials: M
authors.lastname: Bartonová
authors.forename: L
authors.initials: L
authors.lastname: Kovárová
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D015363:Quinolones; D013882:Thiosemicarbazones
vernacular_title: Syntéza a antibakteriální aktivita thiosemikarbazonů nĕkterých 3-acylchinolonů.