2,3,7,8-Tetrachlorodibenzo-p-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene.
We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.
Lusska
A E
AE
Department of Pharmacology, Stanford University School of Medicine, CA 94305.
Jones
K W
KW
Elferink
C J
CJ
Wu
L
L
Shen
E S
ES
Wen
L P
LP
Whitlock
J P
JP
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis / Q000235:genetics*; D002460:Cell Line; D002843:Chromatin / Q000187:drug effects / Q000502:physiology; D004742:Enhancer Elements, Genetic / Q000187:drug effects; D004790:Enzyme Induction; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental; D051379:Mice; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug / Q000187:drug effects / Q000502:physiology*; D014158:Transcription, Genetic / Q000187:drug effects*
D002843:Chromatin; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D011955:Receptors, Drug; D001189:Aryl Hydrocarbon Hydroxylases