Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.
Inositol hexakisphosphate (InsP6) stimulates 45Ca2+ influx in purified mitochondria from rat liver. The action of InsP6 is concentration-dependent, with an apparent EC50 value of 50 microM. Stimulation of 45Ca2+ influx may follow the interaction between InsP6 and specific membrane receptors. Accordingly, [3H]InsP6 binds to specific and saturable recognition sites in purified mitochondria. These results support the view that InsP6 acts as a signal molecule to regulate the intracellular homeostasis of Ca2+.
Copani
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Istituto di Farmacologia, Facoltà di Medicina, Università di Catania.
Raciti
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G
Bruno
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Sortino
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MA
Nicoletti
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Canonico
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PL
Cambria
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D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010833:Phytic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D015290:Second Messenger Systems; D013268:Stimulation, Chemical
D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; C068271:inositol hexakisphosphate receptor; D010833:Phytic Acid; D002118:Calcium