title: Extramammary Paget's disease of the vulva with dermal invasion and vulval intra-epithelial neoplasia.
abstract: Vulval biopsies from a 66-year-old lady complaining of pruritus showed intraepithelial Paget's disease. On simple vulvectomy, extramammary Paget's disease was found to be associated with vulval intra-epithelial neoplasia (VIN III) and superficial dermal invasive adenocarcinoma. Bilateral inguinal lymphadenectomy later revealed metastatic spread of the tumour. We believe this is a unique combination and discuss the possible origins in relation to this lady's past medical history of breast carcinoma 20 years and spinal metastases 17 years before.
authors.affiliation: Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
authors.forename: I C
authors.initials: IC
authors.lastname: Hawley
authors.forename: F
authors.initials: F
authors.lastname: Husain
authors.forename: J
authors.initials: J
authors.lastname: Pryse-Davies
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D010145:Paget Disease, Extramammary / Q000473:pathology*; D014846:Vulvar Neoplasms / Q000473:pathology*