title: Antiviral activity of constituents of Tamus communis.
abstract: The antiviral activity of the phenanthrene derivatives 1-6, of the spyrostane triglycosides dioscin (7) and gracillin (8), of the furostanol tetraglycosides methylprotodioscin (9), its (25S) epimer methylprotoneodioscin (10), and methylprotogracillin 11, have been tested towards two RNA viruses: vesicular stomatitis virus and human rhinovirus type 1B. All these products were extracted from the rizomes of Tamus communis L; compound 11 was isolated also from Asparagus cochinchinesis, together with pseudoprotodioscin (12), a 20 (22)-unsaturated furostanoside, which was also investigated for antiviral activity. The results were of some interest mainly for the phenanthrene derivatives.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Aquino
authors.forename: C
authors.initials: C
authors.lastname: Conti
authors.forename: F
authors.initials: F
authors.lastname: De Simone
authors.forename: N
authors.initials: N
authors.lastname: Orsi
authors.forename: C
authors.initials: C
authors.lastname: Pizza
authors.forename: M L
authors.initials: ML
authors.lastname: Stein
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D010946:Plants, Medicinal; D012367:RNA, Viral; D012229:Rhinovirus / Q000187:drug effects* / Q000502:physiology; D013150:Spirostans / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D013150:Spirostans; C044934:gracillin; C019357:dioscin; D004144:Diosgenin