title: [3 cases of Kituchi's lymphadenitis in systemic lupus erythematosus. Role of the parvovirus B19].
abstract: Florid necrotizing lymphadenitis, characterized by segmental infarction and lymphoid hyperplasia, is an uncommon feature of systemic lupus erythematosus (SLE). Kikuchi's disease is a well-defined clinicopathological entity, with a strong preference for the cervical lymph nodes of young women. The etiology of histiocytic necrotizing lymphadenitis (HNL) remains unknown, although viral agents have been proposed. HNL may reflect a self-limited SLE-like autoimmune disease but full-blown SLE associated with this condition has not, to the best of our knowledge, been reported. Thus, ours is the first description of the coexistence of SLE and HNL in 3 patients with immunologically proven parvovirus B19 infections. SLE and HNL were diagnosed simultaneously in 2 patients, but was retrospective in the third, in whom anti-tuberculous therapy was ineffective. Patients 1 and 2 were treated with prednisone (1 mg/kg/d) and responded rapidly. These data suggest that both HNL and SLE flares can be caused by parvovirus B19 infection.
authors.affiliation: Clinique de Rhumatologie/Universitè, Paris VII.
authors.forename: O
authors.initials: O
authors.lastname: Meyer
authors.forename: P
authors.initials: P
authors.lastname: Ribard
authors.forename: N
authors.initials: N
authors.lastname: Belmatoug
authors.forename: M F
authors.initials: MF
authors.lastname: Kahn
authors.forename: M
authors.initials: M
authors.lastname: Grossin
authors.forename: J C
authors.initials: JC
authors.lastname: Fournet
authors.forename: C
authors.initials: C
authors.lastname: Darne
authors.forename: F
authors.initials: F
authors.lastname: Morinet
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008199:Lymphadenitis / Q000145:classification / Q000209:etiology* / Q000382:microbiology; D008875:Middle Aged; D009336:Necrosis; D010322:Parvoviridae Infections
vernacular_title: Trois cas de lymphadénite de Kikuchi au cours du lupus érythémateux systémique. Rôle du parvovirus B19.