title: [Diagnosis of fetal virus infections by in situ hybridization].
abstract: Non-radioactive in situ hybridization of formalin-fixed paraffin-embedded placental and foetal tissue, using virus-specific DNA or RNA probes, may be helpful for the diagnosis of foetal virus infection causing foetal hydrops, granulomatous placentitis and abortion. We present four cases of intrauterine CMV-, Parvo-B19- and Varicella-Zoster virus infection, in which this diagnostic method established detection of the virus.
authors.affiliation: Abteilung für Klinische Genetik der Philipps-Universität Marburg.
authors.forename: Y
authors.initials: Y
authors.lastname: Mehraein
authors.forename: H
authors.initials: H
authors.lastname: Rehder
authors.forename: H G
authors.initials: HG
authors.lastname: Draeger
authors.forename: U G
authors.initials: UG
authors.lastname: Froster-Iskenius
authors.forename: E
authors.initials: E
authors.lastname: Schwinger
authors.forename: W
authors.initials: W
authors.lastname: Holzgreve
mesh_terms: D000328:Adult; D002644:Chickenpox / Q000473:pathology; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000473:pathology; D015342:DNA Probes; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D007231:Infant, Newborn; D007668:Kidney / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000473:pathology; D010322:Parvoviridae Infections / Q000473:pathology; D016732:Parvovirus B19, Human / Q000302:isolation & purification; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology*; D011296:Prenatal Diagnosis; D015347:RNA Probes; D014777:Virus Diseases / Q000473:pathology*
chemical_list: D015342:DNA Probes; D015347:RNA Probes
vernacular_title: Die Diagnostik fetaler Virusinfektionen durch In-situ-Hybridisierung.