Immune monitoring after renal transplantation. I. HLA-D expression on T cells from renal allograft recipients.
The expression of class II antigens (HLA-DR, DP and DQ) on resting and PHA-activated T cells from renal allograft recipients was studied. A tendency for increase in DR+/DQ+ T cells was noted in azathioprine and cyclosporine-treated recipients undergoing rejection. Low inducible HLA-D expression (especially DP) was associated with CMV infection. Cyclosporine (but not azathioprine) lowered the rate of synthesis of HLA-D by T cells activated in vitro.
Nowaczyk
M
M
Department of Immunology, Medical School, Warsaw.
Górski
A
A
Modlińska
M
M
Rancewicz
Z
Z
Bukowska
J
J
Ołdakowska
U
U
Morzycka-Michalik
M
M
Lao
M
M
D015415:Biomarkers; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006681:HLA-D Antigens / Q000378:metabolism*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology*; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*
D015415:Biomarkers; D006681:HLA-D Antigens