title: The role of HTLV in HIV-1 neurologic disease.
abstract: We performed a serologic survey for antibodies to HTLV-I/II in the course of a longitudinal study of the neurologic complications of HIV-1 infection. Nine (3.7%) of 242 HIV-1 seropositive subjects and none of 60 HIV-1 seronegative control subjects had antibodies to HTLV-I/II by ELISA. Western blot and polymerase chain reaction confirmed the presence of HTLV-I in 2 subjects and HTLV-II infection in 2 others. Both HIV-1/HTLV-I coinfected subjects and 1 HIV-1/HTLV-II coinfected subject had a slowly progressive myelopathy clinically identical tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). The presence of a myelopathy resembling TSP/HAM in the coinfected subjects suggests that HIV-1 may enhance the expression of neurologic disease caused by HTLV. Patients with a progressive myelopathy occurring in association with HIV-1 infection should be serologically tested for the presence of HTLV. Establishing dual infection has therapeutic and prognostic import as 1 of the HIV-1/HTLV-I subjects substantially improved with corticosteroids and the HIV-1/HTLV-II subject with myelopathy had a marked improvement in the absence of therapeutic intervention.
authors.affiliation: Department of Neurology, University of Miami School of Medicine, FL 33136.
authors.forename: J R
authors.initials: JR
authors.lastname: Berger
authors.forename: S
authors.initials: S
authors.lastname: Raffanti
authors.forename: A
authors.initials: A
authors.lastname: Svenningsson
authors.forename: M
authors.initials: M
authors.lastname: McCarthy
authors.forename: S
authors.initials: S
authors.lastname: Snodgrass
authors.forename: L
authors.initials: L
authors.lastname: Resnick
mesh_terms: D000328:Adult; D017977:Deltaretrovirus / Q000302:isolation & purification / Q000502:physiology*; D006800:Deltaretrovirus Infections / Q000150:complications; D004797:Enzyme-Linked Immunosorbent Assay; D004812:Epidemiologic Methods; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000382:microbiology*; D006679:HIV Seropositivity; D015368:Human T-lymphotropic virus 1; D015367:Human T-lymphotropic virus 2; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology / Q000382:microbiology*; D016133:Polymerase Chain Reaction