[The HBx protein expression in liver cancer].
The expression of HBx protein in liver tissues from 48 cases of different liver diseases, including 32 cases of hepatocellular carcinoma (HCC), 10 of chronic hepatitis (CH), 2 of angioma and 4 cases of normal liver was studied. These samples were tested for HBx protein, HBsAg by modified ABC method. Positive rates of HBx in cancer and adjacent liver tissue were 75.0% and 62.5%, and positive rates of HBsAg were 37.5% and 78.1% respectively. The occurrence of HBx in the absence of HBsAg was more frequently observed in tissues from HCC (46.9%) than CH (0%). The results showed that expression of HBx was more active than that of HBsAg, and it is suggested that HBx might be a useful marker for the diagnosis of liver cancer.
Shi
D R
DR
Cancer Institute, Shanghai Medical University.
D014408:Biomarkers, Tumor / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D006505:Hepatitis / Q000378:metabolism; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000378:metabolism*; D015534:Trans-Activators / Q000032:analysis*; D054334:Viral Regulatory and Accessory Proteins
D014408:Biomarkers, Tumor; D006514:Hepatitis B Surface Antigens; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein