[Diffusion of amikacin at the membrane of the round window. Histologic and electrophysiologic study in newborn guinea pigs].
The aim of our study was to evaluate the permeability of the round window membrane for amikacin during postnatal development. The morphologic and electrophysiologic changes in the cochlea were dependent on the applied concentration of amikacin. When giving high doses a complete degeneration of hair cells and deafness could be found. In these cases an influence on the contralateral cochlea could be proved.
Schmitz
K C
KC
HNO-Klinik und Poliklinik, Klinikum rechts der Isar, TU München.
D000583:Amikacin / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn / Q000097:blood / Q000502:physiology*; D003051:Cochlea / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects / Q000378:metabolism; D012405:Round Window, Ear / Q000187:drug effects* / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D000583:Amikacin
Diffusion von Amikacin an der Membran des runden Fensters. Histologische und elektrophysiologische Studie bei neugeborenen Meerschweinchen.