title: [The 3-dimensional organization of the nucleoli of benign and malignant tumor cells from different human organs].
abstract: The method of ultrathin serial sections was used to perform a comparative ultrastructural and 3-dimensional analysis of nucleoli for the following variants of human tumours: benign (fibroadenoma) and malignant (infiltrating ductal carcinoma) tumours of one organ (mammary gland); malignant tumours of epidermal genesis in different organs (squamous cell carcinomas of skin, larynx, lung, gullet, uterus); two forms of malignant tumours (squamous cell and small cell carcinomas) of one organ (lung). The spatial models of nucleoli in these tumour cells are given. The specific signs in architecture of tumour nucleoli was found. Nucleoli of fibroadenomas have well pronounced 1-4 fibrillar centres forming a united system with a lacunar component and intranucleolar chromatin. Unlike benign tumour cells, nucleoli of infiltrating ductal carcinomas are characterized by large, prominent nucleoli containing giant, multiform fibrillar centres with a complicated surface, a well developed granular component and an unusually organized lacunar system. In squamous cell carcinomas of various localization, active, hypertrophied nucleoli with pseudonucleolonemal organization were found. The small cell carcinoma of lung differs from the squamous cell cancer of the same organ by dense, fibrillar nucleoli with a small amount of granular component located on the periphery of the nucleolar body. Nucleolar type reflecting the functional state of malignization process may serve as an additional diagnostic criterion for tumour identification.
authors.forename: P V
authors.initials: PV
authors.lastname: Chelidze
authors.forename: T V
authors.initials: TV
authors.lastname: Todriia
authors.forename: A G
authors.initials: AG
authors.lastname: Agladze
authors.forename: I V
authors.initials: IV
authors.lastname: Topuriia
authors.forename: D G
authors.initials: DG
authors.lastname: Silagadze
authors.forename: K N
authors.initials: KN
authors.lastname: Piradashvili
mesh_terms: D000232:Adenofibroma / Q000648:ultrastructure; D001943:Breast Neoplasms / Q000648:ultrastructure; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000648:ultrastructure; D018288:Carcinoma, Small Cell / Q000648:ultrastructure; D002294:Carcinoma, Squamous Cell / Q000648:ultrastructure; D002466:Cell Nucleolus / Q000648:ultrastructure*; D004938:Esophageal Neoplasms / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000648:ultrastructure; D008175:Lung Neoplasms / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron / Q000379:methods; D009369:Neoplasms / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000648:ultrastructure; D002583:Uterine Cervical Neoplasms / Q000648:ultrastructure
vernacular_title: Trekhmernaia organizatsiia iadryshek dobrokachestvennykh i zlokachestvennykh opukholevykh kletok razlichnykh organov cheloveka.