Platelet imipramine binding in intensive care unit suicidal patients.
3H-Imipramine binding in relation to serotonergic function was studied in patients hospitalized following a suicide attempt. Comparison with a control group showed a highly significant difference in Bmax values. The results suggest, at least a posteriori, a biological alteration as the basis of suicidal behaviour. Although it is impossible to attribute a suicidal attempt to the alteration or to a predisposing pre-existent condition, this biological marker may be useful in evaluating suicidal risk and also short- and long-term prognosis.
De Leo
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D
Department of Psychiatry, University of Padua, School of Medicine, Italy.
Caneva
A
A
Marazziti
D
D
Conti
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L
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D007099:Imipramine / Q000493:pharmacokinetics; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D010554:Personality Disorders / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D011869:Radioligand Assay; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012307:Risk Factors; D013406:Suicide, Attempted / Q000517:prevention & control / Q000523:psychology*
D002352:Carrier Proteins; D011955:Receptors, Drug; D017981:Receptors, Neurotransmitter; C027775:imipramine receptor; D007099:Imipramine