title: Evidence of sex difference in DNA synthesis in hepatocellular carcinoma.
abstract: To clarify sex differences in DNA synthesis in hepatocellular carcinoma (HCC), bromodeoxyuridine labeling indices (BrdU LI) of HCC cells included in tumor biopsy specimens from 12 consecutive male patients and from 5 consecutive female patients all with liver cirrhosis and HCC were examined using an in vitro labeling technique. The mean BrdU LI +/- SE of HCC from male patients (7.7 +/- 0.8%) was significantly (P less than 0.05) higher than that from female patients (4.4 +/- 1.0%). While 7 of the 12 male HCC patients belonged to the high DNA synthesis group (BrdU LI greater than or equal to 7.0%), none of the 5 female HCC patients showed high DNA synthesis (P less than 0.05). We conclude that DNA synthesis in HCC was higher in males than in females.
authors.affiliation: Department of Gastroenterology, Kanagawa Cancer Center, Yokohama.
authors.forename: K
authors.initials: K
authors.lastname: Tarao
authors.forename: A
authors.initials: A
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Kuni
authors.forename: S
authors.initials: S
authors.lastname: Ohkawa
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Tamai
authors.forename: K
authors.initials: K
authors.lastname: Iimori
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimasa
mesh_terms: D000368:Aged; D001973:Bromodeoxyuridine / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004815:Epidermal Growth Factor / Q000032:analysis; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D004273:DNA, Neoplasm; D004815:Epidermal Growth Factor; D001973:Bromodeoxyuridine