Influence of hepatic tumors caused by diethylnitrosamine on hexachlorobenzene-induced porphyria in rats.
The response of female BDVI rats bearing diethylnitrosamine(DENA)-induced hepatic tumors to the porphyrinogenic action of hexachlorobenzene (HCB) was studied. (1) The heme pathway operates in these tumors but they were less affected by HCB than the liver. (2) Tumors did not accumulate porphyrins although the surrounding liver accumulated more porphyrins than livers treated with HCB. (3) DENA/HCB livers which developed a well defined tumor showed slightly less porphyrinogen carboxylyase inhibition and delta-aminolaevulinate synthase induction than HCB rats. (4) The results of the present work suggest that endogenously formed porphyrins would be unable to be accumulated by DENA-induced tumors when the tumoral development precedes the onset of the porphyria.
Wainstok de Calmanovici
R
R
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Cochón
A C
AC
Zenklusen
J C
JC
Aldonatti
C
C
Cabral
J R
JR
San Martín de Viale
L C
LC
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000150:complications* / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004052:Diethylnitrosamine / Q000494:pharmacology*; D005260:Female; D005294:Ferrochelatase / Q000378:metabolism; D006581:Hexachlorobenzene / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000139:chemically induced / Q000150:complications* / Q000378:metabolism; D011162:Porphobilinogen / Q000652:urine; D011164:Porphyrias / Q000209:etiology / Q000378:metabolism*; D011166:Porphyrins / Q000378:metabolism; D051381:Rats
D011166:Porphyrins; D004052:Diethylnitrosamine; D006581:Hexachlorobenzene; D011162:Porphobilinogen; D000622:Aminolevulinic Acid; D003577:Cytochrome P-450 Enzyme System; D000624:5-Aminolevulinate Synthetase; D005294:Ferrochelatase