title: [Purine nucleoside analogs. 5. Acycloguanosine derivatives containing O-alkoxyalkyl substituents in acyclic parts of the molecule].
abstract: A series of new acycloguanosine O-alkoxyalkyl derivatives have been obtained by the reaction of 9-(2-hydroxyethoxymethyl)- and 8-bromo-9-(2-hydroxyethoxymethyl)-N2-acetylguanines with cyclic and acyclic alpha-vinyl ethers. 9-[2-(Alkoxyalkyl)oxyethoxymethyl]-N2-acetylguanines are better soluble in water and low-polar organic solvents as compared with acycloguanosine. The compounds have the pronounced antiviral activity against HSV-I in the experiments in vivo and can be applied as acycloguanosine prodrugs.
authors.forename: M A
authors.initials: MA
authors.lastname: Madre
authors.forename: R A
authors.initials: RA
authors.lastname: Zhuk
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Lidak
mesh_terms: D000212:Acyclovir / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011684:Purine Nucleosides / Q000737:chemistry* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011684:Purine Nucleosides; D000212:Acyclovir
vernacular_title: Analogi purinnukleozidov. 5. Proizvodnye atsikloguanozina, soderzhashchie O-alkoksialkil'nyĭ zamestitel' v atsiklicheskoĭ chasti molekuly.