Scleroglucan sustained release oral preparations. Part II. Effects of additives.
Swelling and diffusion experiments, performed in vitro with tablets prepared with scleroglucan and several hydrophilic and hydrophobic additives, indicate that it is possible to modulate drug delivery from the matrix by appropriate choice of the nature and amount of the additive. The additives in the formulations may affect the mechanisms (zero order, diffusion, erosion) involved in the release of drugs from the dosage forms.
Alhaique
F
F
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive-Università di Roma (La Sapienza) Italy.
Beltrami
E
E
Riccieri
F M
FM
Santucci
E
E
Touitou
E
E
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005079:Excipients; D005936:Glucans / Q000737:chemistry*
D003692:Delayed-Action Preparations; D005079:Excipients; D005936:Glucans; C045938:scleroglucan