title: Anesthetic and nephrotoxic effects of Telazol in New Zealand white rabbits.
abstract: Telazol was evaluated as an anesthetic for rabbits. Two groups of five rabbits each were injected intramuscularly with 32 or 64 mg/kg of Telazol, and the depth and duration of anesthesia period monitored. At both doses, the righting reflex was lost within 2 minutes postinjection. Animals in both groups responded to noxious stimuli for the duration of the anesthesia. Hematology and urinalyses were performed daily for 7 days postinjection. Hematologic parameters remained unchanged in both groups. In the high-dose group, blood urea nitrogen and serum creatinine levels increased 1 day postinjection and continued steadily throughout the week. Elevations in urine protein and the presence of casts correlated with this increase. In the low-dose group, blood urea nitrogen and creatinine levels increased and protein was present in the urine of four of five rabbits beginning approximately 5 days postinjection. Histologically, severe renal tubular necrosis was evident 7 days postinjection in all high-dose rabbits and in three rabbits in the low-dose group. Our results indicate that Telazol does not produce analgesia in rabbits and is nephrotoxic at both 32 and 64 mg/kg. We conclude that Telazol is contraindicated for use in rabbits.
authors.affiliation: Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor 48109-0614.
authors.forename: D W
authors.initials: DW
authors.lastname: Brammer
authors.forename: B J
authors.initials: BJ
authors.lastname: Doerning
authors.forename: C E
authors.initials: CE
authors.lastname: Chrisp
authors.forename: H G
authors.initials: HG
authors.lastname: Rush
mesh_terms: D000777:Anesthetics / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D005260:Female; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D011817:Rabbits; D013045:Species Specificity; D013992:Tiletamine / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D015041:Zolazepam / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000777:Anesthetics; D004338:Drug Combinations; C006131:tiletamine, zolazepam drug combination; D013992:Tiletamine; D015041:Zolazepam