Estradiol-induced adenohypophyseal growth reaction and beta-adrenergic receptors.
The effect of administration of estradiol benzoate on beta-adrenergic receptors of rat adenohypophyseal cells was studied. Twenty days' administration of estradiol benzoate was followed by an increase of adenohypophyseal weight and a decrease in specific binding of 3H-dihydroalprenolol (3H-DHA). In contrast to thyroid hormone treatment which induced an increase in 3H-DHA binding, thyroid hormone treatment decreased both the growth reaction and the reaction of beta-adrenergic receptors after estradiol. Although the relationship between the adenohypophyseal receptors and the growth reaction is unclear, changes in beta-adrenergic receptors after hormonal therapy can be one of pathophysiological conditions that may influence this reaction.
Pacák
K
K
3rd Department of Medicine, Faculty of Medicine, Charles University, Prague.
Nedvídková
J
J
Stolba
P
P
Schreiber
V
V
D000818:Animals; D001835:Body Weight; D004082:Dihydroalprenolol / Q000378:metabolism; D004958:Estradiol / Q000502:physiology*; D008297:Male; D009929:Organ Size; D010903:Pituitary Gland, Anterior / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013963:Thyroid Hormones / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D013963:Thyroid Hormones; D004958:Estradiol; D004082:Dihydroalprenolol