Gas chromatographic-mass spectrometric detection of trace amounts of organic compounds in the intravenous solution Infusio Darrowi.
A gas chromatographic-mass spectrometric procedure was employed to confirm the presence of trace amounts of organic compounds in the intravenous solution Infusio Darrowi. Organic contaminants in the solution analysed were concentrated by microextraction with n-pentane. The main compounds detected were 2,6-di-tert.-butyl-4-methylphenol, 2,6-di-tert.-butyl-4-ethylphenol, 2,6-di-tert.-butyl-4-methoxyphenol, benzothiazole, isomeric C9 alkyl phenols and di(n-butyl) phthalate. These impurities were leached from rubber stoppers during their sterilization into the intravenous solution at levels ranging ca. from 5 x 10(-6) to 5 x 10(-8) g/l.
Lesko
J
J
Laboratory for Mass Spectrometry, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Czechoslovakia.
Jakubik
T
T
Michalkova
A
A
D052160:Benzothiazoles; D003993:Dibutyl Phthalate / Q000032:analysis; D004340:Drug Contamination; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D005947:Glucose / Q000032:analysis*; D007262:Infusions, Intravenous; D007773:Lactates / Q000032:analysis*; D010636:Phenols / Q000032:analysis; D011189:Potassium Chloride / Q000032:analysis*; D012965:Sodium Chloride / Q000032:analysis*; D019354:Sodium Lactate; D012996:Solutions; D013844:Thiazoles / Q000032:analysis
D052160:Benzothiazoles; C035701:Darrows solution; D007773:Lactates; D010636:Phenols; D012996:Solutions; D013844:Thiazoles; D003993:Dibutyl Phthalate; D012965:Sodium Chloride; D011189:Potassium Chloride; C005465:benzothiazole; D005947:Glucose; D019354:Sodium Lactate