Outcome of confirmed symptomatic congenital cytomegalovirus infection.
Sixty five neonates with confirmed symptomatic congenital cytomegalovirus infection were followed up prospectively until they were 3 to 4 year of age. Twenty nine children (45%) had neurological impairment of whom 22 had gross motor or psychomotor abnormalities; in the remaining seven sensorineural deafness was the main abnormality. Infants who had had neurological signs during the neonatal period had a worse prognosis than those who had not, with 16/22 (73%) and 13/43 (30%) having neurological deficit at follow up, respectively. Our results indicate that the prognosis for infants with symptomatic congenital cytomegalovirus infection is better than previously reported.
Ramsay
M E
ME
PHLS Communicable Disease Surveillance Centre, London.
Miller
E
E
Peckham
C S
CS
D001259:Ataxia / Q000209:etiology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000151:congenital*; D003638:Deafness / Q000209:etiology; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008831:Microcephaly / Q000209:etiology; D011379:Prognosis; D011446:Prospective Studies; D011596:Psychomotor Disorders / Q000209:etiology