[Theoretical research for therapy of infection].
Intractable diseases have been showing a steady increase in recent years. Effective antimicrobial treatment is therefore of the utmost importance. Aminoglycosides and quinolones act in a dose-dependent manner and also exert a postantibiotic effect (PAE), they can therefore be given in large doses at a time with long intervals between administrations. beta-lactams, on the other hand, are characterized by time-dependent antimicrobial action and no PAE towards gram-negative bacteria, so they must be administered at relatively frequent intervals to maintain their concentration at the required level of efficacy.
Shimizu
K
K
Department of Internal Medicine, Tokyo Women's Medical College.
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D007769:Lactams; D015363:Quinolones / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007769:Lactams; D015363:Quinolones