Human serum non-antibody inhibitors towards SA-11 rotavirus hemagglutination.
In the present work the non-antibody inhibitory activity of human serum towards SA-11 rotavirus hemagglutination (HA) has been studied. Among human serum protein components, inhibitory activity was recovered in fractions III (beta-globulin), IV (alpha-globulin) and IV (glycoprotein). Additional experiments performed with purified lipoprotein sub-classes and their lipid and apolipoprotein moieties demonstrated the ability of HDL and, HDL1 to prevent SA-11 HA.
Superti
F
F
Laboratorio di Ultrastrutture, Istituto Superiore di Sanità, Roma.
Marchetti
M
M
Seganti
L
L
Conte
M P
MP
Orsi
N
N
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002460:Cell Line; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006387:Hemagglutination, Viral; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D012401:Rotavirus / Q000378:metabolism*; D012712:Serum Globulins / Q000378:metabolism*
D001798:Blood Proteins; D006023:Glycoproteins; D008075:Lipoproteins, HDL; D012712:Serum Globulins