Role of Na+/K+ exchange and organic acids in base induced hyperpolarization of renal proximal amphibian tubule.
Fast peritubular alkaline perturbations in Necturus renal proximal tubule evoke hyperpolarizations of the basolateral membrane. These voltage changes are partly due to an increase in basolateral K(+)-permeability. Additional role of the Na(+)/K(+)-ATPase and organic acids in generating these base induced hyperpolarizations (BIH) can be deduced from the reduction in BIH during low K+, high amiloride or omission of organic acids.
Granitzer
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Departement WNIFysiologie, Limburgs Universitair Centrum, Diepenbeek, Belgium.
Steels
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D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002087:Butyrates / Q000378:metabolism; D020148:Butyric Acid; D007474:Ion Exchange; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000502:physiology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D008564:Membrane Potentials; D009337:Necturus; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D000596:Amino Acids; D002087:Butyrates; D007773:Lactates; D020148:Butyric Acid; D019344:Lactic Acid; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium