title: The effect of cyclosporine on the immunopathogenesis of viral myocarditis in mice.
abstract: The effect of cyclosporine on the immunopathogenesis of viral myocarditis was studied using a murine viral myocarditis model. Mice in the treated group had a higher mortality rate compared with those of the infected control group before day 15 (47/67 vs. 14/31, p less than 0.05). On day 7, treated mice showed higher titers of anti-heart autoantibody than the control group (12 +/- 7 vs 4 +/- 2, p less than 0.05), but no significant difference was seen on day 14 (28 +/- 15 vs. 39 +/- 34). Histologic lesions, lymphocyte subsets in the peripheral blood and heart in situ, the neutralizing antibody, and virus concentrations in the heart showed no significant differences between these groups. This study suggests that with the use of cyclosporine the production of anti-heart autoantibody was enhanced in the early stages of viral myocarditis in mice, and was associated with higher mortality rate.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matoba
authors.forename: A
authors.initials: A
authors.lastname: Matsumori
authors.forename: I
authors.initials: I
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Ohkusa
authors.forename: C
authors.initials: C
authors.lastname: Kawai
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D003524:Cyclosporins / Q000633:toxicity*; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000276:immunology* / Q000473:pathology; D006321:Heart / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009205:Myocarditis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D009206:Myocardium / Q000276:immunology / Q000473:pathology
chemical_list: D001323:Autoantibodies; D003524:Cyclosporins