[Symptomatic cytomegalovirus infection in patients with acquired immunodeficiency syndrome].
During a seven-year period, symptomatic cytomegalovirus (CMV)-infection was diagnosed in 21.5% (n = 10) of all AIDS patients at the National Hospital of Norway (retinitis n = 8, colitis n = 3, pneumonitis n = 2, gastritis n = 1). Symptomatic cytomegalovirus-infection was associated with a poor long-term prognosis (median survival 174 days, range 10-415). Median CD4+ lymphocyte counts at onset of symptomatic cytomegalovirus-infection was 24 x 10(6)/l (range 6-68). Regular ophthalmological examination of HIV-infected patients with severe immunodeficiency, and endoscopy with multiple mucosal biopsies in patients with suspected cytomegalovirus-infection of the gastrointestinal tract, were of major importance in diagnosing symptomatic cytomegalovirus-infection. Six patients received an induction course of ganciclovir, and foscarnet was administered in two patients due to leukopenia. Problems of toxicity to the available anti-CMV agents make the development of additional therapeutic approaches desirable.
Aukrust
P
P
Medisinsk avdeling A, Rikshospitalet, Oslo.
Frøland
S S
SS
Kvale
D
D
Egge
K
K
Farstad
I N
IN
Holter
E
E
Moum
B
B
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D003092:Colitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D005260:Female; D005756:Gastritis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D011379:Prognosis; D012173:Retinitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology
Symptomatisk cytomegalovirusinfeksjon hos pasienter med ervervet immunsviktsyndrom.