[Serotonin and monoamine metabolites in cerebrospinal fluid in children: interrelationships and the influence of age, sex and precursor].
Cerebrospinal fluid and blood were taken from 15 non-neurologic children. Tryptophan(Trp), 5-HTP, 5-HT, 5-HIAA, HVA, MHPG in CSF, and 5-HT, free and total Trp(F-Trp and T-Trp) in serum were determined by HPLC method. Results showed that Trp, 5-HTP, 5-HT, 5-HIAA in CSF were positively correlated significantly. Good correlations were also found between F-Trp in serum and Trp in CSF (C-Trp), 5-HIAA and HVA, 5-HTP and MHPG. C-Trp, 5-HTP, 5-HT, 5-HIAA and HVA declined significantly with increasing age. MHPG was higher in male than in female children.
Liao
W
W
Hunan Medical University, Changsha.
D000367:Age Factors; D015306:Biogenic Monoamines / Q000097:blood / Q000134:cerebrospinal fluid*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid*; D012737:Sex Factors
D015306:Biogenic Monoamines