[Synovial cytokines facilitate the development of spontaneous nerve root activity following compression].
The nerve roots of Wistar rats were studied electrophysiologically following exposure to synovial cytokines. A total of 12 rats was examined. In the experimental series a preparation of synovial cytokines (50 microliters, 250 micrograms protein) was injected into the S1 nerve root of 6 Wistar rats. Six animals served as controls and were injected with a similar solution lacking cytokines. Forty-eight hours after this procedure the S1 nerve root was compressed by a force of 0.2 N for 1 hour. EMG recordings at mid-gastrocnemius levels were performed during, and 3 hours after, compression. The neurophysiological testing performed 3 hours after compression showed a significantly higher level of compression-induced muscle activity in the cytokine group compared to the control.
Wehling
P
P
Orthopädische Klinik, Heinrich-Heine-Universität Düsseldorf.
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D004576:Electromyography; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D009132:Muscles / Q000294:innervation; D009408:Nerve Compression Syndromes / Q000503:physiopathology*; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013126:Spinal Nerve Roots / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology*; D013582:Synovial Fluid / Q000502:physiology*
D016207:Cytokines
Synoviale Zytokine begünstigen die Entstehung spontaner Nervenwurzelaktivität nach Kompression.