Neoplasia associated with feline immunodeficiency virus infection in cats of southern California.
Between 1988 and 1991, feline immunodeficiency virus (FIV) infection status was evaluated in 1,160 cats examined at an oncology referral and general practice in Los Angeles, California. Twenty-nine (2.5%) cats were FIV positive. Neoplasia was present in 18 of the 29 (62%) cats. Sampling for neoplasia was intentionally biased in the oncology referral group. However, 33% (6/18) of FIV-infected cats with neoplasia originated from the general practice. Three neoplastic processes were observed; myeloproliferative disease (MPD; 5/18), lymphoma (LSA; 5/18), and squamous cell carcinoma (SCC; 7/18). One cat had LSA and SCC. Extranodal sites of LSA were common (66%) in FIV-infected cats. Sites of LSA were submandibular and mesenteric lymph nodes, liver, kidneys, periorbital area, and diffuse (heart, pancreas, bladder). Sites of SCC were sublingual (n = 2), nasal planum (n = 3), nasal planum and eyelids (n = 1), and mandible (n = 2). Feline leukemia virus co-infection was observed in 17% (5/29) of FIV-infected cats. The FIV-infected cats with MPD were young (range, 8 months to 13 years; median, 4 years) and had short survival duration (2, 6, 21, 134, 249 days) even in response to aggressive treatment. The FIV-infected cats with LSA were older (median age, 8 years; range, 4 to 14 years) and survived 60 days if untreated. Cats administered chemotherapy survived 39, 45, 217, and 243 days; the latter 2 cats had partial remission of 2 months' duration. Older FIV-infected cats had SCC (median age, 12 years; remission range, 7 to 16 years) because of more frequent association of both diseases in older cats with outdoor environment.(ABSTRACT TRUNCATED AT 250 WORDS)
Hutson
C A
CA
Animal Cancer Center, Hermosa Beach, CA 90254.
Rideout
B A
BA
Pedersen
N C
NC
D000367:Age Factors; D000818:Animals; D002140:California / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D002371:Cat Diseases / Q000453:epidemiology* / Q000209:etiology; D002415:Cats; D005260:Female; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D016180:Lentivirus Infections / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D008297:Male; D009196:Myeloproliferative Disorders / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*