[Effect of selenium on the connective tissue metabolism in rats].
Rats were chronically exposed to poisonous sodium selenite in concentrations 0.5 mg/kg b. m. for 10 weeks. As a result, hydroxyproline contents in blood serum increased, as well as its excretion with urine. It was proved that the procedure enhanced urinary glycosaminoglycane excretion and increased the contents of the protein-related glycosaminoglycanes in the serum. This was accompanied by increased quantities of keratane sulphate and heparin sulphate. The results confirmed that selenium poisonings influenced connective tissues.
Kucharz
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EI
Olczyk
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Sonecki
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P
D000818:Animals; D002908:Chronic Disease; D003238:Connective Tissue / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D006025:Glycosaminoglycans / Q000378:metabolism*; D006909:Hydroxyproline / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000506:poisoning*; D018038:Sodium Selenite; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000506:poisoning*
D006025:Glycosaminoglycans; D014874:Water Pollutants, Chemical; D012643:Selenium; D018038:Sodium Selenite; D006909:Hydroxyproline
Vliianie selena na metabolizm soedinitel'noĭ tkani u krys.