Pyridoindole stobadine is a potent scavenger of hydroxyl radicals.
Stobadine is a potent scavenger of OH. radicals generated chemically in a free solution with kappa 2 higher than 10(10).M-1.s-1 as determined by two independent methods, namely destruction of deoxyribose and oxidation of 2-keto-4-methiolbutyric acid (KMBA). The high efficacy of stobadine to prevent ethylene production from KMBA was observed also in enzymatic (xanthine-xanthine oxidase-driven Fenton) and membrane-bound (NADPH-dependent microsomal electron transfer) sources of OH. radicals.
Stefek
M
M
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Benes
L
L
D000818:Animals; D001667:Binding, Competitive; D002243:Carbolines / Q000737:chemistry / Q000494:pharmacology*; D003855:Deoxyribose / Q000378:metabolism; D004579:Electron Transport; D005030:Ethylenes / Q000378:metabolism; D016166:Free Radical Scavengers; D006878:Hydroxides / Q000737:chemistry* / Q000378:metabolism; D017665:Hydroxyl Radical; D007700:Kinetics; D008297:Male; D008715:Methionine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000494:pharmacology; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D019820:Xanthine; D014969:Xanthine Oxidase / Q000378:metabolism; D014970:Xanthines / Q000378:metabolism
D002243:Carbolines; D005030:Ethylenes; D016166:Free Radical Scavengers; D006878:Hydroxides; D014970:Xanthines; D019820:Xanthine; D017665:Hydroxyl Radical; D009249:NADP; D003855:Deoxyribose; C014632:2-keto-4-methylthiobutyric acid; C036216:ethylene; D008715:Methionine; D014969:Xanthine Oxidase; C100106:dicarbine