[Binding of apolipoproteins to HDL receptors sites. Role in the efflux of cholesterol].
Cell surface binding sites recognizing artificial or native particles containing human apoAI, apoAII and/or apoAIV have been characterized in mouse Ob1771 adipose cells. These sites appear to be required for the promotion of cholesterol efflux from an intracellular pool. Two apoA-binding proteins of 92 and 80 kDa have been extensively purified from Ob1771 adipose cells. The critical role of both lipoprotein and receptor sites in cholesterol efflux is discussed.
Ailhaud
G
G
Centre de Biochimie (CNRS UMR 134), Université de Nice-Sophia Antipolis.
D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism; D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism*; D001665:Binding Sites; D002784:Cholesterol / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011956:Receptors, Cell Surface / Q000378:metabolism*
D001053:Apolipoproteins; D008075:Lipoproteins, HDL; D011956:Receptors, Cell Surface; D002784:Cholesterol
Liaison des apolipoprotéines aux sites récepteurs des HDL. Rôle dans l'efflux de cholésterol.