title: Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia.
abstract: The prevalence of antibodies to hepatitis C virus (HCVAb) was investigated in 52 unselected patients with mixed cryoglobulinemia and in 84 patients with other systemic immunologic diseases. HCVAb were detected by an enzyme-linked immunosorbent assay, and their specificity was evaluated by a recombinant-based immunoblot assay. The presence of HBV-related markers was investigated in the same samples. HCVAb were found in 54% of mixed cryoglobulinemia patients, and the finding was confirmed by recombinant-based immunoblot assay in all cases. HCVAb and/or HBV markers were present in 70% of the patients. HCVAb seropositivity was significantly more frequent in mixed cryoglobulinemia patients with biopsy-proven liver involvement (P less than 0.01) and with increased serum transaminase levels (P less than 0.01). HCVAb were virtually absent in control patients with other immunologic diseases. These results support the notion that viral agents, i.e., HCV and possibly HBV, have a role in the pathogenesis of mixed cryoglobulinemia patients.
authors.affiliation: Rheumatology Unit, University of Pisa, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ferri
authors.forename: F
authors.initials: F
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Longombardo
authors.forename: P
authors.initials: P
authors.lastname: Palla
authors.forename: A
authors.initials: A
authors.lastname: Moretti
authors.forename: E
authors.initials: E
authors.lastname: Marzo
authors.forename: P V
authors.initials: PV
authors.lastname: Fosella
authors.forename: G
authors.initials: G
authors.lastname: Pasero
authors.forename: S
authors.initials: S
authors.lastname: Bombardieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003449:Cryoglobulinemia / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood* / Q000276:immunology / Q000502:physiology; D006801:Humans; D015151:Immunoblotting; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D006508:Hepatitis Antibodies