Effect of olean-9(11), 12-diene-3 beta, 30-diol 3 beta, o-hemisuccinate Na salt, a glycyrrhetinic acid derivative, on peroxidation in CCl4 induced mouse acute hepatitis.
Anti-hepatitis effect of the olean-9(11),12-diene-3 b, 30-diol 3 b, o-hemisuccinate Na Salt (III b), a glycyrrhetinic acid derivative, was studied in CCl4 induced mouse. The mouse was administered i.p. with 0.1 mole/kg or 0.2 mole/kg of III b, then followed by 31.4 microliters/kg of CCl4. III b was shown to promote the activity of the glucose-6-phosphatase, lower the content of malondialdehyde, and prevent the activity from the soluble enzyme(i.e. GPT, GOT, LDH) from flowing out in the serum enzyme and liver homogenate. III b had the similar anti-peroxidation effect as vitamin E and can maintain the liver function.
Huang
W T
WT
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000097:blood / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005952:Glucose-6-Phosphatase / Q000097:blood / Q000378:metabolism; D006034:Glycyrrhetinic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice
C074797:olean-9(11),12-diene-3,30-diol 3-O-hemisuccinate; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005952:Glucose-6-Phosphatase; D006034:Glycyrrhetinic Acid