Biology of female sex hormone action in relation to contraceptive agents and neoplasia.
This article will present an overview of estrogen and progestin action at a cellular level, with emphasis on points that are relevant to neoplasia. In breast, endometrium and ovary, these two classes of hormone are clearly implicated in carcinogenesis, but their involvement with cancers of the liver, cervix and other tissues is more problematic. In the latter situations, I will highlight the major points to be considered if the hormones are involved without wishing to judge whether there actually is a causal involvement.
King
R J
RJ
Biochemistry Department, University of Surrey, Guildford, United Kingdom.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000139:chemically induced / Q000209:etiology*; D011372:Progestins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000032:analysis
D003276:Contraceptives, Oral; D004967:Estrogens; D011372:Progestins; D011956:Receptors, Cell Surface