title: The activities of aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetases in MPC-11 and Krebs II ascites cells.
abstract: The activity of aminoacyl-tRNA synthetase phosphatase as well as the activities of aminoacyl-tRNA synthetases in Krebs II ascites cells and MPC-11 cells have been investigated. The activity of the phosphatase was greater in the tumor cells than in normal tissues. The aminoacyl-tRNA synthetase activities were 100-300 times higher than the activities found in the uterus of ovariectomized mice, but not very different from the activities found in the liver. The influence of cyclic AMP. 2-deoxyadenosine 3-phosphate and 2-deoxyguanosine 3-phosphate on the growth of MPC-11 cells, grown in suspension culture, was also investigated.
authors.affiliation: Department of Biochemistry, University of Bergen, Norway.
authors.forename: I F
authors.initials: IF
authors.lastname: Pryme
authors.forename: B H
authors.initials: BH
authors.lastname: Berg
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000604:Amino Acyl-tRNA Synthetases / Q000032:analysis*; D000818:Animals; D001201:Ascites / Q000201:enzymology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line / Q000201:enzymology; D000242:Cyclic AMP / Q000494:pharmacology; D003838:Deoxyadenine Nucleotides / Q000494:pharmacology; D005260:Female; D008099:Liver / Q000201:enzymology; D051379:Mice; D008807:Mice, Inbred BALB C; D010749:Phosphoprotein Phosphatases / Q000032:analysis*; D010954:Plasmacytoma / Q000201:enzymology*; D016196:S Phase; D014407:Tumor Cells, Cultured / Q000201:enzymology; D014599:Uterus / Q000201:enzymology
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D003838:Deoxyadenine Nucleotides; D000242:Cyclic AMP; C022354:phosphoaminoacyl-tRNA synthetase phosphatase; D010749:Phosphoprotein Phosphatases; D000604:Amino Acyl-tRNA Synthetases; C026600:2'-deoxyadenosine triphosphate