title: Malignant conjunctival epibulbar fibrous histiocytoma with orbital invasion.
abstract: The Authors report on a rare case of malignant conjunctival epibulbar fibrous histiocytoma with orbital invasion. Fibrous histiocytoma is a tumour of mesenchymal origin, which, although among the most common adult age soft tumours, appears very rarely at the conjunctival level. In fact the most frequent site is the orbit. So far only 15 cases concerning conjunctiva have been described in the Literature only 4 of those have been reported as malignant. We observed a male patient, who 6 years ago, at the age of 53, noticed a neoformation on the temporal portion of the bulbar conjunctiva. In June 1988, after three successive operations, with a histological diagnosis of inflammatory granuloma, he came to our Clinic, where, because of the characteristics of the orbit infiltrations, only a partial excision was carried out for a biopsy. The histological examination, associated with immunohistochemical techniques, gave the result of malignant fibrous histiocytoma. Consequently in, July 1988, the patient underwent an exenteratio orbitae. To date, the patient enjoys good health without a trace of recurrence. Besides the clinical presentation of the case, histopathological and immunohistochemical findings concerning this type of lesion are presented and discussed, with a comparison of our findings with those reported in the literature.
authors.affiliation: University of L'Aquila, Eye Clinic, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Balestrazzi
authors.forename: T
authors.initials: T
authors.lastname: Ventura
authors.forename: N
authors.initials: N
authors.lastname: Delle Noci
authors.forename: M A
authors.initials: MA
authors.lastname: Blasi
authors.forename: L
authors.initials: L
authors.lastname: Spadea
authors.forename: G
authors.initials: G
authors.lastname: Coletti
mesh_terms: D003230:Conjunctival Neoplasms / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009915:Orbit / Q000473:pathology; D009918:Orbital Neoplasms / Q000473:pathology*