[The effect of alcohol on the mitochondrial respiratory chain in the cardiac muscle].
The authors investigated the action of prolonged 2- and 3-week action of ethanol on the main parameters of oxidative processes and on the cytochrome content of mitochondria in the heart muscle in 3-month-old rats. They found a statistically significant reduction of the oxidative phosphorylation coefficient, the rate of energy formation and a transient increase of the cytochrome oxidase activity in mitochondria. Under these experimental conditions an increase of cytochromes (cyt aa3, b, c, c1, bc1, c + c1) in mitochondria of the heart muscle occurred.
Gvozdjáková
A
A
Farmakobiochemické laboratórium LF UK, Bratislava.
Kucharská
J
J
Miklovicová
E
E
Bozek
P
P
Gvozdják
J
J
D000818:Animals; D003580:Cytochromes / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D003580:Cytochromes; D000431:Ethanol; D003576:Electron Transport Complex IV
Vplyv alkoholu na dýchací retazec mitochondrií srdcového svalu.