The procalcitonin amino-terminal cleavage peptide (N-proCT) lacks biological activity on normal clonal rat osteoblastic and preosteoblastic cells in vitro.
The human-derived procalcitonin amino-terminal cleavage peptide, N-proCT has previously been shown to act mitogenically on isolated chicken and human osteoblast-like cells and on the human osteosarcoma cell line U-2 OS. We have examined the effect of N-proCT on growth and phenotype of cloned rat osteoblastic and preosteoblastic cells. Neither cell growth nor the phenotype (ALP, PTH response) of either cell type was significantly changed by the procalcitonin cleavage peptide.
Guenther
H L
HL
Department of Pathophysiology, University of Berne, Switzerland.
Fleisch
H
H
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide; D002455:Cell Division / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D000242:Cyclic AMP / Q000032:analysis; D010006:Osteoblasts / Q000187:drug effects* / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology*; D011498:Protein Precursors / Q000494:pharmacology*; D051381:Rats
C000606589:CALCA protein, human; C000606591:Calca protein, rat; D010446:Peptide Fragments; D011498:Protein Precursors; D002116:Calcitonin; D000242:Cyclic AMP; D000469:Alkaline Phosphatase; D015740:Calcitonin Gene-Related Peptide