Immunovirology of transforming viruses.
The paradigmatic shift in cellular immunology, initiated by the realization that cytotoxic T lymphocytes recognize major histocompatibility complex class I antigens that carry endogenous (including virally encoded) protein-derived peptides in a special groove, has made a strong impact on the immunopathology of virus-associated tumors.
Klein
G
G
Karolinska Institutet, Stockholm, Sweden.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D006528:Carcinoma, Hepatocellular / Q000382:microbiology; D002472:Cell Transformation, Viral / Q000276:immunology; D015658:HIV Infections / Q000150:complications; D006509:Hepatitis B / Q000150:complications; D006515:Hepatitis B virus / Q000276:immunology / Q000472:pathogenicity; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D015368:Human T-lymphotropic virus 1 / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D016867:Immunocompromised Host; D007157:Immunologic Surveillance; D008113:Liver Neoplasms / Q000382:microbiology; D008223:Lymphoma / Q000276:immunology / Q000382:microbiology; D051379:Mice; D008817:Mice, Mutant Strains; D009858:Oncogenic Viruses / Q000276:immunology / Q000502:physiology*; D027383:Papillomaviridae / Q000276:immunology / Q000472:pathogenicity; D016511:Severe Combined Immunodeficiency / Q000150:complications / Q000276:immunology; D012878:Skin Neoplasms / Q000276:immunology / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000951:Antigens, Neoplasm; D000956:Antigens, Viral