Infection and reactivation with cytomegalovirus strains in lung transplant recipients.
Cytomegalovirus pneumonia is a major cause of morbidity and death following lung transplantation (LT) (1). The case fatality rate is highest in the CMV-seronegative recipients (R-) of organs from seropositive donors (D+), which suggests that transmission of CMV may occur with the graft (1), but in seropositive recipients (R+) the comparative importance of reactivation of endogenous virus and reinfection with donor virus is poorly understood.
Smyth
R L
RL
Department of Medicine, Addenbrooke's Hospital, Cambridge, England.
Sinclair
J
J
Scott
J P
JP
Gray
J J
JJ
Higenbottam
T W
TW
Wreghitt
T G
TG
Wallwork
J
J
Borysiewicz
L K
LK
D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000209:etiology*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D011014:Pneumonia / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D014775:Virus Activation