title: Autoradiographic evidence of 125I-beta-endorphin binding sites in the articular cartilage of the rat.
abstract: After 125I-beta-endorphin was intravenously injected to rats, an autoradiographic study of distal femur articular cartilage was performed. Results show a specific binding of 125I-beta-endorphin to chondrocytes, suggesting the possible existence of an opiate modulation of articular cartilage.
authors.affiliation: Department of Anatomy, School of Medicine, University of Santiago, Spain.
authors.forename: M T
authors.initials: MT
authors.lastname: Castaño
authors.forename: M
authors.initials: M
authors.lastname: Freire-Garabal
authors.forename: M
authors.initials: M
authors.lastname: Giraldez
authors.forename: M J
authors.initials: MJ
authors.lastname: Núñez
authors.forename: A
authors.initials: A
authors.lastname: Belmonte
authors.forename: J
authors.initials: J
authors.lastname: Couceiro
authors.forename: J
authors.initials: J
authors.lastname: Jorge
mesh_terms: D000818:Animals; D001345:Autoradiography; D002358:Cartilage, Articular / Q000378:metabolism*; D006614:Hindlimb; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D001615:beta-Endorphin / Q000378:metabolism*
chemical_list: D011957:Receptors, Opioid; D009270:Naloxone; D001615:beta-Endorphin; D009020:Morphine