title: Continuous hemofiltration with a low molecular weight heparin, enoxaparine: report on two cases.
abstract: The heparinization of multiple trauma patients during hemofiltration involves a high risk of bleeding. We report here two continuous hemofiltration cases -15 and 60 days in duration-using a low molecular weight heparin, enoxaparine. No major bleeding or clotting was observed. However, continuous infusion of the heparin is needed and the rate of delivery of the hemofiltration pump must be taken into consideration since it influences the clearance of the drug through the hemofiltration membrane. Anti-Xa activity measurement is not sufficient to adjust the heparin dose.
authors.affiliation: Laboratoire d'hématologie, CHU Hôpital du Bocage, Université de Bourgogne, Dijon, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Lorenzini
authors.forename: M
authors.initials: M
authors.lastname: Freysz
authors.forename: D
authors.initials: D
authors.lastname: Honnart
authors.forename: V
authors.initials: V
authors.lastname: Zeller
authors.forename: F
authors.initials: F
authors.lastname: Dutrillaux
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy; D000328:Adult; D006440:Hemofiltration; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009104:Multiple Trauma / Q000628:therapy
chemical_list: D006495:Heparin, Low-Molecular-Weight