[Effect of the treatment with oxydevit on calcium metabolism, immune status and 1,25(OH)2D3 receptors in the lymphocytes of children with glomerulonephritis].
In all the examined children with chronic glomerulonephritis (GN), peripheral blood lymphocytes had a high concentration of receptors of 1,25 (OH)2D3, a hormonal form of vitamin D. At the same time as to the healthy children, 1,25 (OH)2D3 receptors were identified only in 27%, with the concentration being lower. A large amount of 1,25 (OH)2D3 receptors may be related to the expression of the hormone in activated lymphocytes. In addition to the normalization of calcium metabolism, the treatment with oxydevit favoured the normalization of the content of IgG and T lymphocytes as well as a reduction (to normal) of the content of 0 lymphocytes regardless of the previous treatment. Partial remission was attained in 14 out of 20 GN patients. In 10 of these children, the remission lasting 1-2 years was attained for the first time. In 17 children treated with oxydevit, the incidence of acute respiratory viral infection decreased from 6-8 times to 1-2 times a year. The data obtained allowed one to ascertain the immunomodulatory capacities of oxydevit in children with chronic glomerulonephritis.
Rusnak
F I
FI
Naumova
V I
VI
Sergeev
I N
IN
Pletsityĭ
K D
KD
D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D002117:Calcitriol / Q000378:metabolism*; D002118:Calcium / Q000097:blood*; D002648:Child; D002908:Chronic Disease; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D015433:Glomerulonephritis, Membranous / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D006887:Hydroxycholecalciferols / Q000008:administration & dosage; D007958:Leukocyte Count / Q000187:drug effects; D009402:Nephrosis, Lipoid / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D014807:Vitamin D / Q000627:therapeutic use*
D006887:Hydroxycholecalciferols; D011956:Receptors, Cell Surface; D014807:Vitamin D; C030850:1-hydroxyprevitamin D3; D002117:Calcitriol; D002118:Calcium
Vliianie lecheniia oksidevitom na obmen kal'tsiia, immunnyĭ status i retseptory 1,25(OH)2D3 v limfotsitakh u deteĭ s glomerulonefritom.