Non-competitive NMDA-receptor antagonists and anoxic degeneration of the ERG B-wave in vitro.
Studies have been undertaken to see if the non-competitive NMDA antagonists, ketamine, MK-801 and dextromethorphan would preserve the b-wave of the electroretinogram (ERG) in vitro. The drugs had no effect on the ERG b-wave, nor prolonged its survival postmortem. The present results support previous evidence suggesting that NMDA-receptors are not involved directly in synaptic transmission between photoreceptors and ON-bipolar cells. Further, loss of the b-wave in post-mortem anoxia does not appear to be mediated via NMDA-receptors.
Huang
J C
JC
Institute of Ophthalmology, London.
Salt
T E
TE
Voaden
M J
MJ
Marshall
J
J
D000818:Animals; D003915:Dextromethorphan / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004596:Electroretinography / Q000187:drug effects; D005260:Female; D066298:In Vitro Techniques; D007649:Ketamine / Q000494:pharmacology; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*; D012160:Retina / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology; D013997:Time Factors
D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D007649:Ketamine; D016291:Dizocilpine Maleate; D003915:Dextromethorphan