[Progressive cytomegalovirus encephalitis in successful ganciclovir therapy of cytomegalovirus retinitis in an AIDS patient].
We describe a case of an HIV-infected intravenous drug-abuser who died of progressive cytomegalovirus encephalitis despite successful treatment of cytomegalovirus retinitis with ganciclovir. On autopsy, complete remission of retinitis and widespread cytomegalovirus-encephalitis could be demonstrated. Therapeutic failure therefore seems attributable to insufficient CNS-distribution of ganciclovir rather than to ganciclovir-resistant cytomegalovirus strains.
Ewig
S
S
Medizinische Klinik der Universität Bonn.
Bierhoff
E
E
Luster
W
W
Steudel
A
A
Niese
D
D
D015526:AIDS Dementia Complex / Q000188:drug therapy* / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D001921:Brain / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000473:pathology; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D012173:Retinitis / Q000188:drug therapy* / Q000473:pathology
D015774:Ganciclovir
Progrediente Zytomegalie-Enzephalitis unter erfolgreicher Ganciclovir-Therapie einer Zytomegalie-Retinitis bei einem AIDS-Patienten.