The effect of famotidine on neuromuscular transmission.
We have investigated the effects of the H2 receptor antagonist famotidine on the neuromuscular transmission by using the sciatic nerve--gastrocnemius muscle preparation of rat in vitro. Famotidine, administered by I.V. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and aminoglycoside antibiotics. Moreover, the drug alone is capable of producing a blockade on the preparation stimulated at high frequency. The neuromuscular blockade induced by famotidine is reversed by 4-aminopyridine but not by dimaprit. Similar results have previously been obtained with cimetidine.
Bossa
R
R
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica Emilio Trabucchi, Università di Milano, Italy.
Chiericozzi
M
M
Efstathiu
G
G
Galatulas
I
I
Ninci
M A
MA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004357:Drug Synergism; D015738:Famotidine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects / Q000294:innervation; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects; D012853:Sisomicin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009466:Neuromuscular Blocking Agents; D015738:Famotidine; D010197:Pancuronium; D014403:Tubocurarine; D012853:Sisomicin