title: Temporal distribution of human rotavirus serotypes 1,2,3, and 4 in Venezuelan children with gastroenteritis during 1979-1989.
abstract: The temporal distribution and clinical severity of rotavirus VP7 serotypes 1, 2, 3, and 4 recovered from 427 Venezuelan children with acute gastroenteritis over a period of 11 years were studied. Rotavirus VP7 serotype was established by ELISA serotyping in 298 (69.78%) of the specimens while the serotype of the remaining 129 (30.21%) samples could not be determined. Of the specimens typed, 85 (19.90% of the total) were serotype 1, 43 (10.07%) were serotype 2, 105 (24.59%) were serotype 3, and 65 (15.22%) were serotype 4. Yearly changes in the frequency of individual serotypes were observed. The predominance of a single serotype with minor contribution from others was noted every year. In this study, serotype 1 appears to induce a less severe illness in comparison with serotypes 2, 3, and 4. No apparent association between the proportion of each serotype and the children's age were found.
authors.affiliation: Instituto de Biomedicina, Universidad Central de Venezuela, Ministerio de Sanidad y Asistencia Social, Caracas.
authors.forename: L
authors.initials: L
authors.lastname: White
authors.forename: D
authors.initials: D
authors.lastname: García
authors.forename: Y
authors.initials: Y
authors.lastname: Boher
authors.forename: M
authors.initials: M
authors.lastname: Blanco
authors.forename: M
authors.initials: M
authors.lastname: Pérez
authors.forename: H
authors.initials: H
authors.lastname: Romer
authors.forename: J
authors.initials: J
authors.lastname: Flores
authors.forename: I
authors.initials: I
authors.lastname: Pérez-Schael
mesh_terms: D000956:Antigens, Viral; D002213:Capsid / Q000276:immunology*; D036022:Capsid Proteins; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology; D005759:Gastroenteritis / Q000382:microbiology*; D006801:Humans; D007223:Infant; D012401:Rotavirus / Q000145:classification* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000382:microbiology*; D012703:Serotyping; D013997:Time Factors; D014687:Venezuela
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; C050779:VP7 protein, Rotavirus