Dactinomycin inhibits non-cholinergic bronchoconstriction by capsaicin-sensitive sensory nerves in the guinea-pig by antagonizing neurokinin 2 receptor activation.
Lundberg
J M
JM
Department of Pharmacology, Karolinska Institute, Stockholm, Sweden.
Lou
Y P
YP
D000818:Animals; D016084:Bronchoconstriction / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology*; D006168:Guinea Pigs; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000187:drug effects* / Q000502:physiology
D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; D003609:Dactinomycin; D002211:Capsaicin