The mouse homolog of the Gibbon ape leukemia virus receptor: genetic mapping and a possible receptor function in rodents.
The mouse homolog of the Gibbon ape leukemia virus (GALV) receptor (Glvr-1) was mapped to mouse Chromosome 2 (Chr 2) by Southern blot analysis of somatic cell hybrids and positioned on this chromosome using an interspecies genetic cross. Mouse Chr 2 also encodes a receptor (Rec-2) for the wild mouse virus M813. To investigate whether Glvr-1 and Rec-2 could be the same gene, we sought evidence for sequence homology between the env- genes of their respective viruses. Southern blot hybridization with GALV-derived env and pol-env probes failed to detect any homology between GALV and M813, but did show that all mouse species tested carry numerous copies of GALV-related sequences. We speculate that a functional receptor for GALV-related viruses was expressed during Mus evolution.
Adamson
M C
MC
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Silver
J
J
Kozak
C A
CA
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D015752:Genes, env; D006922:Hylobates; D009052:Leukemia Virus, Murine / Q000378:metabolism*; D051379:Mice; D016133:Polymerase Chain Reaction; D011991:Receptors, Virus / Q000235:genetics* / Q000378:metabolism; D015301:Retroviruses, Simian / Q000378:metabolism*; D012689:Sequence Homology, Nucleic Acid
D011991:Receptors, Virus