title: Proton editing and imaging of lactate.
abstract: Highly specific NMR assays for the detection, quantitation and imaging of lactate in vivo are described. Applications in animals include tumor monitoring, the determination of hypoxic cell distribution and the demonstration of the efficacy of tumor-sensitizers. The methods (GE-DQCOSY and GE-HMQC) may be particularly useful in heteronuclear NMR in vivo.
authors.affiliation: GE Medical Systems, NMR Instruments, Fremont, CA 94539.
authors.forename: R E
authors.initials: RE
authors.lastname: Hurd
authors.forename: D
authors.initials: D
authors.lastname: Freeman
mesh_terms: D000818:Animals; D006830:Hydralazine / Q000494:pharmacology; D007773:Lactates / Q000032:analysis*; D019344:Lactic Acid; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D051379:Mice; D008809:Mice, Inbred C3H; D008961:Models, Structural; D009374:Neoplasms, Experimental / Q000175:diagnosis / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology; D011522:Protons
chemical_list: D007773:Lactates; D011522:Protons; D009536:Niacinamide; D006830:Hydralazine; D019344:Lactic Acid