title: Induction of microsomal drug metabolizing enzymes by phenobarbitone in the rats exposed to increased environmental temperature.
abstract: Exposure of rats for 3 consecutive days (6 h a day) to 28 degrees C or 35 degrees C does not lead to changes in the induction of hepatic microsomal cytochrome P-450 associated monooxygenases by phenobarbitone as compared with control animals exposed to 21 degrees C. These results suggest that environmental temperature does not change the capacity of phenobarbitone to induce drug metabolizing enzymes in rat liver.
authors.affiliation: Department of Drug Metabolism, School of Medicine, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Pachecka
authors.forename: K
authors.initials: K
authors.lastname: Kobylińska
authors.forename: H
authors.initials: H
authors.lastname: Zasłona
authors.forename: B
authors.initials: B
authors.lastname: Zagdańska
authors.forename: W
authors.initials: W
authors.lastname: Bicz
mesh_terms: D000818:Animals; D004781:Environmental Exposure; D004790:Enzyme Induction / Q000187:drug effects; D006361:Heating; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013696:Temperature
chemical_list: D006899:Mixed Function Oxygenases; D010634:Phenobarbital