Halothane-induced relaxation of vascular smooth muscle: a possible contribution of increased cyclic GMP formation.
Halothane (0.75 to 2.25%) dose-dependently relaxed the vascular smooth muscle of endothelium-denuded rat aortae previously contracted with KCl, and the relaxing effect was not significantly affected by indomethacin nor dexamethasone, but partly inhibited by methylene blue. The cyclic GMP levels were increased by treatment with halothane (2.25%). It was suggested that halothane-induced relaxation of vascular smooth muscle is partly mediated by cyclic GMP formation.
Nakamura
K
K
Department of Anesthesia, Kyoto University Hospital, Japan.
Hatano
Y
Y
Toda
H
H
Nishiwada
M
M
Baek
W Y
WY
Mori
K
K
D000818:Animals; D006152:Cyclic GMP / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology; D006221:Halothane / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008751:Methylene Blue / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D003907:Dexamethasone; D006152:Cyclic GMP; D008751:Methylene Blue; D006221:Halothane; D007213:Indomethacin