title: Mucolytic-antifoam solution for reduction of artifacts during endoscopic ultrasonography: a randomized controlled trial.
abstract: Gastric mucus and air bubbles are frequent sources of artifacts during endoscopic ultrasonography (EUS). To reduce these artifacts, we prepared a mucolytic-antifoam solution consisting of simethicone, acetylcysteine, and sodium bicarbonate and performed a prospective randomized and controlled trial comparing this solution (21 patients) to a placebo (22 patients) during EUS. Eight patients in the drug group received a perfect score for both mucolytic and antifoam effect compared with none in the placebo group (p less than 0.001). For overall rating, the drug group received a total of 10 excellents and 9 goods compared with 9 goods, 10 satisfactories, and 1 unacceptable in the placebo group (p less than 0.001). There were no complications associated with the solution. In conclusion, a mucolytic-antifoam solution improved endoscopic visualization and reduced artifacts during EUS study. Its routine use during EUS procedures is therefore recommended.
authors.affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: A
authors.initials: A
authors.lastname: Yiengpruksawan
authors.forename: C J
authors.initials: CJ
authors.lastname: Lightdale
authors.forename: H
authors.initials: H
authors.lastname: Gerdes
authors.forename: J F
authors.initials: JF
authors.lastname: Botet
mesh_terms: D000111:Acetylcysteine; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016477:Artifacts; D001639:Bicarbonates; D004066:Digestive System Diseases / Q000000981:diagnostic imaging*; D004311:Double-Blind Method; D004338:Drug Combinations; D016145:Endoscopy, Digestive System; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012841:Simethicone; D012964:Sodium; D017693:Sodium Bicarbonate; D012996:Solutions; D014463:Ultrasonography
chemical_list: D001639:Bicarbonates; D004338:Drug Combinations; D012996:Solutions; D012841:Simethicone; D017693:Sodium Bicarbonate; D012964:Sodium; D000111:Acetylcysteine