title: Selective increase of AMPA binding to the AMPA/quisqualate receptor in the hippocampus in response to acute stress.
abstract: The binding properties of ligands specific for two subclasses of glutamate receptors were studied by quantitative autoradiography after one hour of acute immobilization/shock stress. [3H]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine (TCP) and [3H]alpha-amino-3-methylisoxazole-4-propionic acid (AMPA) were used to visualize the N-methyl-D-aspartate receptor and the AMPA/quisqualate receptor types, respectively. While no change was observed in the binding properties of the [3H]TCP, [3H]AMPA binding was significantly increased in several areas of the hippocampus of acutely stressed rats relative to naive controls.
authors.affiliation: Neurosciences Program, University of Southern California, Los Angeles 90089-2520.
authors.forename: G
authors.initials: G
authors.lastname: Tocco
authors.forename: T J
authors.initials: TJ
authors.lastname: Shors
authors.forename: M
authors.initials: M
authors.lastname: Baudry
authors.forename: R F
authors.initials: RF
authors.lastname: Thompson
mesh_terms: D000818:Animals; D001345:Autoradiography; D004597:Electroshock; D006624:Hippocampus / Q000033:anatomy & histology / Q000378:metabolism*; D007051:Ibotenic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
chemical_list: D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D007051:Ibotenic Acid; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; C012058:tenocyclidine; D010622:Phencyclidine