[Zinc sulfate and thyroxine treatment on the obese patients].
Zinc has recently been found to have important effects on metabolism and thermoregulation of obese individuals. The effects of zinc sulfate and thyroxine treatment on the obese patients were studied. The obese patients, selected from outpatients at the Taichung VGH, all had their body weight 20% higher than they normally should have, and body mass indexes (BMI = Wt/Ht2) greater than 25 kg/m2. They were separated into three groups to have 600mg zinc sulfate or/and 0.1mg thyroxine per day, respectively. Serum zinc and copper contents were determined by atomic absorption spectrometer. The alterative of body weight was also recorded. After 8 weeks of therapy, the zinc sulfate and zinc sulfate + thyroxine treatment had more significant effects on weight reduction (male: -1.10 +/- 0.38; -1.10 +/- 0.19, female: -1.75 +/- 0.19; -3.16 +/- 0.21 kg, P less than 0.05, respectively). The serum zinc content was found to inversely relate to the body weight reduction (r = -0.605, P less than 0.001). The results also showed that zinc sulfate and thyroxine treatment did not have satisfactorily greater effects on body weight reduction at short-term therapy on obese patients. We conclude that zinc therapy on the obese patients still need more evaluation and suggest that zinc may have important effects on the thyroid hormones conversion, and may have certain regulatory effects on the insulin activity through its interaction with thyroid hormones in the development of obesity.
Chen
M D
MD
Department of Medicine, Taichung Veterans General Hospital.
Lin
W H
WH
Lin
P Y
PY
D000328:Adult; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000188:drug therapy*; D013431:Sulfates / Q000008:administration & dosage*; D013974:Thyroxine / Q000008:administration & dosage*; D015032:Zinc / Q000008:administration & dosage*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D015032:Zinc; D013974:Thyroxine