Daptomycin disrupts membrane potential in growing Staphylococcus aureus.
Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (delta psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (delta pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available delta psi.
Alborn
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Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Allen
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Preston
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DA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology; D017576:Daptomycin; D005434:Flow Cytometry; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials / Q000187:drug effects; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology; D010457:Peptidoglycan / Q000096:biosynthesis; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
D000900:Anti-Bacterial Agents; D010455:Peptides; D010457:Peptidoglycan; D017576:Daptomycin; D002118:Calcium