title: Ifosfamide and mitomycin in combination for the treatment of patients with progressive advanced non-small cell lung cancer.
abstract: 42 patients with progressive and advanced non-small cell lung cancer received chemotherapy comprising ifosfamide 1.5 g/m2, mesna 1.5 g/m2 and mitomycin 1.2 mg/m2 daily for 5 days. Only those patients with symptoms and progressive disease were selected for treatment. Partial response was achieved in 10/42 patients (23.8%) and stable disease in 25/42 (59.5%). The Karnofsky performance status (KP) improved in 10/42 patients (23.8%) and a subjective respiratory symptom score improved in 12 patients (28.6%). In addition 27 patients (64.3%) had stabilisation of both the KP and respiratory score following chemotherapy. These results indicate that the ifosfamide and mitomycin combination is active in non-small cell lung cancer in this selected group of patients with antitumour and symptom control activity.
authors.affiliation: Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
authors.forename: H
authors.initials: H
authors.lastname: Gurney
authors.forename: E S
authors.initials: ES
authors.lastname: de Campos
authors.forename: D
authors.initials: D
authors.lastname: Dodwell
authors.forename: A
authors.initials: A
authors.lastname: Kamthan
authors.forename: N
authors.initials: N
authors.lastname: Thatcher
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008875:Middle Aged; D008937:Mitomycins / Q000008:administration & dosage; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: D008937:Mitomycins; D007069:Ifosfamide