Results of the central data analysis.
This chapter presents the results of blind serological studies carried out by workshop participants on 87 monoclonal antibodies (mAbs) supplied to them as a coded panel. Twenty six mAbs had been studied in the first workshop. Participants were asked to carry out immunohistochemical, immunocytological or flow cytometric analysis on a mandatory panel of target tissues or cells. Central computer analysis and other supporting data allowed the assignment of 33 mAbs to seven clusters. Two of the antigens identified have been cloned while two more have been defined as carbohydrate epitopes. The results allow comparison of new mAbs against lung cancer with existing ones and are beginning to provide a description of the antigenic structure of the SCLC cell surface.
Beverley
P C
PC
Imperial Cancer Research Fund, University College and Middlesex School of Medicine, Courtauld Institute of Biochemistry, London.
Olabiran
Y
Y
Ledermann
J A
JA
Bobrow
L G
LG
Souhami
R L
RL
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D018288:Carcinoma, Small Cell / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D013223:Statistics as Topic; D014018:Tissue Distribution
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm