[The characteristics of the cholinergic reaction of the portal vein in the rat liver].
The kinetics of M-cholinergic response to acetylcholine and effects of phenylephrine and phentolamine on the functional state of M-cholinoceptors, were studied on the rat isolated vein. Two discrete pools of M-cholinoceptors differing in their sensitivity by a factor of 7.5, were found. Functional interaction between M-cholinoceptors and alpha-adrenoceptors was established as manifested in a change of basic parameters of M-cholinergic reaction (K and Pm) when the alpha-adrenoceptors were activated or blocked. The activation or blockade of specific alpha-adrenoceptors seems to evoke conformational changes of cell membrane thus modulating the affinity to the M-cholinoceptors agonist.
Manukhin
B N
BN
Nesterova
L A
LA
Shalymov
B K
BK
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011169:Portal Vein / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology
D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D010656:Phenylephrine; D000109:Acetylcholine; D010646:Phentolamine
Osobennosti kholinergicheskoĭ reaktsii vorotnoĭ veny pecheni krysy.