title: Changes in the rat lymphoid tissues after Leydig cell destruction by ethane-1,2-dimethanesulphonate.
abstract: Since ethane-1,2-dimethanesulphonate (EDS) causes Leydig cell destruction which may elicit an immune response the lymphoid tissues of sexually mature male rats were examined after an intraperitoneal injection of EDS. The changes observed in the testicular regional lymph nodes confirm an immune response while those observed in the thymus may indicate involvement in the immunological response or be a toxic reaction to EDS.
authors.affiliation: University of Manchester, Department of Cell and Structural Biology, U.K.
authors.forename: G
authors.initials: G
authors.lastname: Leeming
authors.forename: R G
authors.initials: RG
authors.lastname: Lendon
authors.forename: J M
authors.initials: JM
authors.lastname: McLean
authors.forename: I D
authors.initials: ID
authors.lastname: Morris
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007985:Leydig Cells / Q000187:drug effects*; D008198:Lymph Nodes / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology*; D008297:Male; D008698:Mesylates / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000276:immunology
chemical_list: D008698:Mesylates; C002994:ethylene dimethanesulfonate