title: [A horse with Cushing's disease].
abstract: A thirteen-year-old Dutch warmblooded mare was referred to the Faculty of Veterinary Medicine because of a sinusitis. She was thin with a potbellied appearance. Her coat was dull with long wavy hair. Unilateral (left) purulent nasal discharge was evident. A cbc revealed leucopenia (3.9 G.L.-1) and plasma biochemical analysis revealed a plasma glucose concentration of 10.1 mmol.L-1. Thermostable alkaline phosphatase (at 65 degrees C during 2 minutes) could not be demonstrated. Basal plasma cortisol concentration was lowered (114 nmol.L-1) and basal plasma ACTH concentration was highly elevated (815 pg.ml-1), indicating adrenocortical insufficiency. A dexamethasone-suppression test was performed by intramuscular administering of 10 mg of dexamethasone showing a suppression of 32% instead of at least 50%. At necropsy a pituitary pars intermedia adenoma was found.
authors.affiliation: Vakgroep Inwendige Ziekten en Voeding der Grote Huisdieren, Faculteit Diergeneeskunde, Utrecht.
authors.forename: J H
authors.initials: JH
authors.lastname: van der Kolk
authors.forename: W R
authors.initials: WR
authors.lastname: Klein
authors.forename: S W
authors.initials: SW
authors.lastname: van der Putten
authors.forename: J A
authors.initials: JA
authors.lastname: Mol
mesh_terms: D000236:Adenoma / Q000150:complications / Q000662:veterinary; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D003480:Cushing Syndrome / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000097:blood* / Q000209:etiology; D006736:Horses; D006854:Hydrocortisone / Q000097:blood; D010911:Pituitary Neoplasms / Q000150:complications / Q000662:veterinary
chemical_list: D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone
vernacular_title: Een paard met de ziekte van Cushing.