Autoradiographic distribution of sigma receptors in human neocortex, hippocampus, basal ganglia, cerebellum, pineal and pituitary glands.
Autoradiographic distributions of [3H]1,3-di-O-tolylguanidine, [3H]DTG, binding to sigma (sigma) receptors were studied in key human brain regions. High densities occurred in the substantia nigra pars compacta and cerebellum. Pineal and pituitary levels were moderate. In neocortex, binding was high in laminae II-IVA and much lower in the midzone. Moderate binding occurred over hippocampal dentate granular cells and in the striatum. These results differ from those reported for the rodent.
Jansen
K L
KL
Department of Anatomy, University of Auckland, School of Medicine, New Zealand.
Faull
R L
RL
Dragunow
M
M
Leslie
R A
RA
D000328:Adult; D001345:Autoradiography; D001479:Basal Ganglia / Q000033:anatomy & histology / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D002531:Cerebellum / Q000033:anatomy & histology / Q000378:metabolism; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism; D005260:Female; D006146:Guanidines / Q000494:pharmacology; D006624:Hippocampus / Q000033:anatomy & histology / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010870:Pineal Gland / Q000033:anatomy & histology / Q000378:metabolism; D010902:Pituitary Gland / Q000033:anatomy & histology / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D017480:Receptors, sigma
D006146:Guanidines; D011957:Receptors, Opioid; D017480:Receptors, sigma; C050232:1,3-ditolylguanidine