[The effect of various doses of ascorbic acid on the development of pneumofibrosis, caused by silicon dioxide].
Long-term administration of ascorbic acid into rats with silicosis retarded lung fibrosis development. Noticeable effect exhibited daily administration of the vitamin in high doses (10 mg per a rat or 40 mg/kg of body mass) which caused statistically distinct decrease in the pneumofibrosis process both within early steps of silicosis (3-6 weeks) and during the developed pneumofibrosis (14 weeks).
Mironova
G E
GE
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D012822:Silicon Dioxide / Q000633:toxicity*
D012822:Silicon Dioxide; D001205:Ascorbic Acid
Vliianie razlichnykh doz askorbinovoĭ kisloty na razvitie pnevmofibroza, vyzvannogo dvuokis'iu kremniia.