title: [Cushing's syndrome due to bilateral adrenal macronodular hyperplasia. From ACTH-dependent hypercortisolism to ACTH-independent hypercortisolism].
abstract: A 35 year old female with Cushing's syndrome and bilateral adrenal macronodular hyperplasia, in whom a change from ACTH dependency to autonomy was observed, is presented. The diagnosis of Cushing's syndrome was based on the failure of suppression of urinary ketogenic steroids (17 KCS) and free cortisol (uF) with the administration of 2 mg of dexamethasone daily for 2 days. CT scan of the abdomen showed adrenal bilateral multinodular hyperplasia and the sellar CT scan was normal. Initially 8 mg for 2 days of dexamethasone suppressed 17 KCS and uF; however, a few months later this effect was lost as well as the effect of endogenous ACTH on cortisol. Bilateral adrenalectomy was carried out, prior to attainment of normal cortisol levels with Ketoconazole. The adrenal glands has multiple nodules and they weighed 10 and 21 grams. Her postoperative plasmatic cortisol levels were imperceptible. Physiopathologic mechanisms involved in bilateral macronodular adrenal hyperplasia are reviewed.
authors.affiliation: Departamento de Endocrinología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago.
authors.forename: J M
authors.initials: JM
authors.lastname: López
authors.forename: J
authors.initials: J
authors.lastname: Sapunar
authors.forename: J
authors.initials: J
authors.lastname: Donoso
authors.forename: P
authors.initials: P
authors.lastname: Martínez
mesh_terms: D000311:Adrenal Glands / Q000473:pathology*; D000308:Adrenocortical Hyperfunction / Q000150:complications; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000328:Adult; D003480:Cushing Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000097:blood / Q000150:complications; D014057:Tomography, X-Ray Computed
chemical_list: D000324:Adrenocorticotropic Hormone
vernacular_title: Sindrome de Cushing por hiperplasia suprarenal bilateral macronodular. Del hipercortisolismo dependiente al independiente de ACTH.