title: Phosphoinositide signalling system in red blood cells of patients with hereditary spherocytosis.
abstract: Hereditary spherocytosis (HS) is characterised with many deviations of red blood cells properties. We investigated a group of 14 patients with mild HS, 7 of whom were splenectomised. We found changes in the content and/or turnover of polyphosphoinositides and phosphatidic acid accompanied by the higher generation of inositol 1,4,5-trisphosphate. We suggest that the activation of the phosphoinositide signalling system may be crucial for the manifestation of HS.
authors.affiliation: Department of Physiology and Developmental Biology, Faculty of Sciences, Charles University, Prague, Czechoslovakia.
authors.forename: A
authors.initials: A
authors.lastname: Strunecká
authors.forename: L
authors.initials: L
authors.lastname: Krpejsová
authors.forename: E
authors.initials: E
authors.lastname: Kmonícková
authors.forename: H
authors.initials: H
authors.lastname: Hrůsová
authors.forename: H
authors.initials: H
authors.lastname: Jakoubková
authors.forename: T
authors.initials: T
authors.lastname: Marík
authors.forename: V
authors.initials: V
authors.lastname: Brabec
mesh_terms: D002118:Calcium / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000097:blood; D010710:Phosphates / Q000097:blood; D010712:Phosphatidic Acids / Q000097:blood; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000097:blood* / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction; D013103:Spherocytosis, Hereditary / Q000097:blood*; D013156:Splenectomy
chemical_list: D010710:Phosphates; D010712:Phosphatidic Acids; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C037178:phosphatidylinositol 4-phosphate; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium