[Effect of double-stranded RNA and interferon type I on reproduction of cytomegalovirus in human fibroblasts].
Double-stranded RNAs (dsRNA) - larifan and ridostin, and recombinant interferons-alpha-2 and beta-1, manufactured in the USSR, inhibited the reproduction of CMV in cell culture. Antiviral effect depended on concentration of preparations, time of administration and m. o. i. DEAE-dextran enhances antiviral effect dsRNA. DsRNA and interferons added to cells infected with CMV at high m. o. i. enhance the viral reproduction. Among studied preparations highest antiviral effect was shown by natural leucocyte interferon (Egis). It was 10 times more active, than recombinant IFNs and in concentration of 1000 U/ml was comparable to activity of larifan (200 mg/ml).
Sokolova
T M
TM
Fatkhutdinova
N G
NG
Nosik
N N
NN
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000187:drug effects / Q000254:growth & development*; D005347:Fibroblasts; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology; D007370:Interferon Type I / Q000494:pharmacology*; D009930:Organic Chemicals; D012330:RNA, Double-Stranded
D000998:Antiviral Agents; D007369:Interferon Inducers; D007370:Interferon Type I; D009930:Organic Chemicals; D012330:RNA, Double-Stranded; C066530:larifan
Effekt dvuspiral'nykh RNK i interferonov tipa I na reproduktsiiu tsitomegalovirusa v fibroblastakh cheloveka.