Arachidonic acid metabolism in human and bovine retina.
Arachidonic acid (AA) metabolism in the human and bovine retina was assessed. This study demonstrates that the human and bovine retina can synthesize prostaglandin (PG) E2, F2 alpha, I2, D2 and thromboxane A2 from 14C-AA. This tissue also synthesized leukotriene (LT) B4 and 12-hydroxyeicosatetraenoic acid (12-HETE). Although human and bovine retina metabolized AA into PGs and LTs, the ability to synthesize these products was considerably less than some other ocular tissues of various species.
Kulkarni
P S
PS
Department of Ophthalmology and Visual Science, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D002417:Cattle; D002855:Chromatography, Thin Layer; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis; D007975:Leukotriene B4 / Q000096:biosynthesis; D011453:Prostaglandins / Q000096:biosynthesis; D011863:Radioimmunoassay; D012160:Retina / Q000378:metabolism*; D013928:Thromboxane A2 / Q000096:biosynthesis
D006893:Hydroxyeicosatetraenoic Acids; D011453:Prostaglandins; D007975:Leukotriene B4; D016718:Arachidonic Acid; D013928:Thromboxane A2; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid