Virus-associated hemophagocytic syndrome following bone marrow transplantation.
Multiple-organ infiltration by mature, benign erythrophagocytic histiocytes is the pathologic hallmark of the virus-associated hemophagocytic syndrome (VAHS). Although VAHS has been described in a number of clinical settings, it has been reported following bone marrow transplantation (BMT) only once previously. Our report identifies the clinical and laboratory features associated with VAHS and compares the immune defects described in VAHS with those known to occur following BMT.
Reardon
D A
DA
Department of Pediatrics, University of Michigan Medical School, Ann Arbor.
Roskos
R
R
Hanson
C A
CA
Castle
V
V
D000257:Adenoviridae Infections / Q000209:etiology* / Q000276:immunology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007694:Killer Cells, Natural / Q000276:immunology; D009102:Multiple Organ Failure / Q000209:etiology; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery