[Familial background of patients with Gilles de la Tourette's disease].
A study was made of hereditary loading of probands with Gilles de la Tourette's syndrome (GTS) and of the degree of genetic homogeneity of the clinical varieties of the disturbance. Among 131 relatives of the patients, GTS was encountered in 1.52% of cases, whereas tics in 8.3% on the whole. It turned out as a result of a genetico-statistical analysis of different varieties of GTS that the excitable and inhibited subtypes of the typical Tourette's syndrome are homogeneous in terms of their hereditary loading and significantly differ (p greater than 0.05) from schizophrenia with Tourette-like disorders in the pathology of the schizophrenic spectrum (schizophrenia, schizoid psychopathy). Schizophrenia with Tourette-like disorders is genetically similar to sluggish schizophrenia of childhood (p = 0.95). In homogeneous hereditary predisposition to hyperkineses, their clinical diversity is determined both by the ground which gives rise to their development and by contribution of environmental factors.
Kozlova
I A
IA
Smirnov
A Iu
AIu
D000328:Adult; D000437:Alcoholism / Q000150:complications / Q000235:genetics*; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D012559:Schizophrenia / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000150:complications / Q000175:diagnosis / Q000235:genetics*; D005879:Tourette Syndrome / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000523:psychology
Semeĭnyĭ fon bol'nykh s sindromom Zhilia de lia Turetta.