[The effect of N-bromoacetamide on the components of sodium channel inactivation in the membrane of Ranvier's node].
In voltage clamp experiments on the frog Ranvier node, the specific protein reagent, N-bromacetamide, significantly decelerates the sodium inactivation kinetics and makes it incomplete. After treatment with N-bromacetamide, both fast and slow inactivation time constants are increased and the proportion of inactivation components is changed favouring the slowly inactivating one in the wide range of membrane potentials. The results are consistent with a single channel population following the 3-state model of inactivation.
Lonskiĭ
A V
AV
Krutetskaia
Z I
ZI
Roshchina
N G
NG
P'iankova
S V
SV
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009441:Neurilemma / Q000187:drug effects* / Q000502:physiology; D010477:Perfusion / Q000379:methods; D011895:Rana ridibunda; D011901:Ranvier's Nodes / Q000187:drug effects* / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology
D000081:Acetamides; D015222:Sodium Channels; C016272:N-bromoacetamide
Vliianie N-bromatsetamida na komponenty inaktivatsii natrievykh kanalov membrany perekhvata Ranv'e.