[Pharmacological regulation of opioidergic antinociceptive mechanisms].
Naloxone-depending potentiation of morphine antinociception by some non-opioidergic compounds between different classes of drugs was found in experiments on mice using nociceptive stimuli of different modality. This potentiation can or cannot be bound with elevation of sensitivity of opioid receptors, release of endogenous opioids or destruction of blood-brain barrier function mor morphine peripheral administration. This potentiation named as "release of functional reserve of opioid antinociceptive response" can or cannot be accompanied by an increase of breathing function depression. Taking into account the data of literature about the dissociation of analgetic positive-supporting morphine effects and also the capability of some compounds to lower the narcogenic opiates potential, the supposition about the real possibility of creating combined drugs is made.
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D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D004357:Drug Synergism; D004723:Endorphins / Q000378:metabolism; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D011957:Receptors, Opioid / Q000187:drug effects*; D016713:Ritanserin / Q000494:pharmacology
D004723:Endorphins; D011957:Receptors, Opioid; D016713:Ritanserin; D009270:Naloxone; D009020:Morphine; D003000:Clonidine
Farmakologicheskaia reguliatsiia opioidergicheskikh antinotsitseptivnykh mekhanizmov.