Existence of a digitalis-like compound in the human fetus.
Digoxin-like inhibitors of Na+,K(+)-ATPase have been implicated in several pathophysiological problems in the perinatal period. Aqueous endogenous digoxin-like immunoreactive substance (DLIS) was extracted from 9 different organs of a 24-week-old human fetus whose mother died after paraquat poisoning. The results indicate that this endogenous DLIS has a wide distribution in fetal tissues. The highest levels were found in gut and adrenals, and there was a correlation between these high levels and the inhibition of Na+,K(+)-ATPase. The hypothesis that DLIS originated in the fetus is of particular relevance.
Guédeney
X
X
INSERM U 26, Hôpital Fernand-Widal, Paris, France.
Chanez
C
C
Scherrmann
J M
JM
D001798:Blood Proteins / Q000032:analysis* / Q000494:pharmacology; D002298:Cardenolides; D003429:Cross Reactions; D004077:Digoxin / Q000032:analysis; D005333:Fetus / Q000737:chemistry* / Q000201:enzymology; D006801:Humans; D011863:Radioimmunoassay; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D001798:Blood Proteins; D002298:Cardenolides; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase