title: The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7.
abstract: By means of somatic cell hybrids segregating either human or rat chromosomes, the genes encoding the transcription factor Sp1 (SP1) and the 1,25-dihydroxyvitamin D3 receptor (VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This result implies that the locus for the clinical disorder vitamin D dependency rickets type II maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-gamma (RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating that a synteny group is conserved on these chromosomes.
authors.affiliation: Département de Biologie Moléculaire, Université Libre de Bruxelles, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Szpirer
authors.forename: C
authors.initials: C
authors.lastname: Szpirer
authors.forename: M
authors.initials: M
authors.lastname: Riviere
authors.forename: G
authors.initials: G
authors.lastname: Levan
authors.forename: P
authors.initials: P
authors.lastname: Marynen
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
authors.forename: R
authors.initials: R
authors.lastname: Wiese
authors.forename: H F
authors.initials: HF
authors.lastname: DeLuca
mesh_terms: D000818:Animals; D015139:Blotting, Southern; D002117:Calcitriol / Q000378:metabolism*; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D006822:Hybrid Cells; D051381:Rats; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000235:genetics* / Q000378:metabolism; D016329:Sp1 Transcription Factor / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D016329:Sp1 Transcription Factor; D002117:Calcitriol