[The effect of sodium oxybutyrate on various regulatory mechanisms of pulmonary hemodynamics in experimental tuberculosis in dogs].
The role of cyclic nucleotides and prostaglandins E1 and F2 alpha in pulmonary hypertension formation was elucidated in experimental tuberculosis in dogs and the mechanism of a hypotensive action of sodium oxybutyrate specified with consideration of its influence on the non-gas exchange pulmonary function. The level of the above compounds was studied in the blood taken from the pulmonary artery and aorta in comparison with pulmonary artery pressure prior to and after intravenous injection of sodium oxybutyrate, an antihypoxant. Pulmonary vessel tone was found to depend on the cGMP content and synthesis in the lungs both in health and in tuberculosis and pulmonary hypertension in tuberculosis was associated with a deranged level and correlation of cAMP, cGMP and prostaglandins E1 and F2 alpha in pulmonary circulation. It has been demonstrated that the hypotensive effect of sodium oxybutyrate is associated with its influence on these biochemical parameters in plasma.
Borisova
M I
MI
Kremer
O V
OV
Smirnova
N A
NA
Simonian
V G
VG
D000527:Alprostadil / Q000378:metabolism; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D006152:Cyclic GMP / Q000378:metabolism; D015237:Dinoprost / Q000378:metabolism; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D006976:Hypertension, Pulmonary / Q000378:metabolism; D008168:Lung / Q000503:physiopathology*; D011453:Prostaglandins / Q000378:metabolism; D012978:Sodium Oxybate / Q000494:pharmacology*; D014397:Tuberculosis, Pulmonary / Q000378:metabolism / Q000503:physiopathology*
D011453:Prostaglandins; D012978:Sodium Oxybate; D015237:Dinoprost; D000242:Cyclic AMP; D000527:Alprostadil; D006152:Cyclic GMP
Vliianie natriia oksibutirata na nekotorye reguliatornye mekhanizmy legochnoĭ gemodinamiki pri éksperimental'nom tuberkuleze u sobak.