Biomarkers of OH radical damage in vivo.
Mechanisms of formation of o-tyrosine (o-Tyr) and thymine glycol (TG), the two possible markers of OH radical generation in biosystems and in vivo are described. The o-Tyr measurements require invasive approaches, while TG detection may be accomplished by noninvasive analysis in the urine.
Karam
L R
LR
Center for Radiation Research, National Institute of Standards and Technology, Gaithersburg, MD 20899.
Bergtold
D S
DS
Simic
M G
MG
D015415:Biomarkers; D004247:DNA / Q000187:drug effects; D005609:Free Radicals; D006878:Hydroxides / Q000633:toxicity*; D017665:Hydroxyl Radical; D006900:Hydroxylation; D010649:Phenylalanine / Q000187:drug effects; D011506:Proteins / Q000187:drug effects; D013941:Thymine / Q000031:analogs & derivatives* / Q000378:metabolism; D013942:Thymine Nucleotides / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*
D015415:Biomarkers; D005609:Free Radicals; D006878:Hydroxides; D011506:Proteins; D013942:Thymine Nucleotides; C029389:thymine glycol; D017665:Hydroxyl Radical; D014443:Tyrosine; D010649:Phenylalanine; C026741:2-tyrosine; D004247:DNA; D013941:Thymine