Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.
In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.
Ishioka
C
C
Department of Clinical Cancer Chemotherapy, Tohku University, Sendai, Japan.
Sato
T
T
Gamoh
M
M
Suzuki
T
T
Shibata
H
H
Kanamaru
R
R
Wakui
A
A
Yamazaki
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D007700:Kinetics; D008761:Methylhistamines / Q000378:metabolism; D008969:Molecular Sequence Data; D011224:Prazosin / Q000378:metabolism; D011738:Pyrilamine / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011968:Receptors, Histamine / Q000302:isolation & purification / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism; D018100:Receptors, Histamine H3; D013569:Synapses / Q000502:physiology
D008761:Methylhistamines; D011942:Receptors, Adrenergic, alpha; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D018100:Receptors, Histamine H3; D011738:Pyrilamine; D011224:Prazosin; C048140:N-methylhistamine