title: Human responses to inhaled capsaicin are not inhibited by granisetron.
abstract: Cough is a common respiratory symptom, the mechanism of which is poorly understood. In this study the role of 5-HT3 receptors was investigated. Capsaicin-induced cough and increase in airways resistance were measured in six male volunteers before and after infusion with granisetron 160 micrograms kg-1 or placebo. Neither cough nor the increase in respiratory resistance was altered by the active treatment. These results suggest that 5-HT3 receptors are not involved in these two respiratory responses to inhaled capsaicin in humans.
authors.affiliation: Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.
authors.forename: N B
authors.initials: NB
authors.lastname: Choudry
authors.forename: J R
authors.initials: JR
authors.lastname: McEwan
authors.forename: E A
authors.initials: EA
authors.lastname: Lavender
authors.forename: A J
authors.initials: AJ
authors.lastname: Williams
authors.forename: R W
authors.initials: RW
authors.lastname: Fuller
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D002211:Capsaicin / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003371:Cough / Q000503:physiopathology; D017829:Granisetron; D006801:Humans; D007191:Indazoles / Q000494:pharmacology*; D008297:Male; D012018:Reflex / Q000187:drug effects; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D002211:Capsaicin; D017829:Granisetron; D007191:Indazoles; D012702:Serotonin Antagonists