title: The role of reactive oxygen species, cytokines and cytochrome P450 in pulmonary damage due to hyperoxia.
abstract: The exact mechanism of hyperoxic damage and the (therapeutic) protection against these lesions are still a matter of debate. Recent experimental studies indicated a role for cytokines, cytochrome P450, and antioxidant enzymes in protection against O2 toxicity. In this paper a hypothesis is presented linking all these factors to cytochrome P450 oxidase as a central enzyme.
authors.affiliation: Department of Occupational and Environmental Health and Toxicology, University of Limburg, Maastricht, Holland.
authors.forename: C
authors.initials: C
authors.lastname: Sprong
authors.forename: Y M
authors.initials: YM
authors.lastname: Janssen
authors.forename: P J
authors.initials: PJ
authors.lastname: Borm
mesh_terms: D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D004731:Endotoxins / Q000494:pharmacology; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism; D015227:Lipid Peroxidation; D008171:Lung Diseases / Q000139:chemically induced*; D051379:Mice; D008954:Models, Biological; D009251:NADPH-Ferrihemoprotein Reductase; D010088:Oxidoreductases / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D013481:Superoxides / Q000378:metabolism; D013552:Swine
chemical_list: D016207:Cytokines; D004731:Endotoxins; D005609:Free Radicals; D013481:Superoxides; D003577:Cytochrome P-450 Enzyme System; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D009251:NADPH-Ferrihemoprotein Reductase; D010100:Oxygen