title: Biopsies of non-small cell lung cancer: central review in cooperative studies of the Radiation Therapy Oncology Group.
abstract: Cooperative trials involving many institutions have long been recognized as a major means of gaining enough experience in a reasonably short period of time to determine the effectiveness of new approaches in cancer therapy. In order to make such multiinstitutional trials meaningful, it is necessary to have uniform and objective diagnostic standards in histopathology. Large cooperative therapeutic trials, such as the Radiation Therapy Oncology Group (RTOG) constructs, must rely on the histopathologic diagnoses of many pathologists from varied institutions or subject them to central review, which is a longer and costlier process. This study is an assay of the need for central review in cooperative studies on non-small cell lung cancer, which includes squamous cell, large cell, adenocarcinomas, and combined squamous cell and adenocarcinomas.
authors.affiliation: Yale Medical School, New Haven, Connecticut.
authors.forename: R
authors.initials: R
authors.lastname: Yesner
authors.forename: G H
authors.initials: GH
authors.lastname: Seydel
authors.forename: S O
authors.initials: SO
authors.lastname: Asbell
authors.forename: J D
authors.initials: JD
authors.lastname: Cox
authors.forename: M
authors.initials: M
authors.lastname: Bauer
authors.forename: K H
authors.initials: KH
authors.lastname: Shin
authors.forename: R
authors.initials: R
authors.lastname: Byhardt
authors.forename: C
authors.initials: C
authors.lastname: Perez
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy; D001706:Biopsy; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000532:radiotherapy