title: Hepatic sinusoidal ectasia.
abstract: Oral contraceptive-associated sinusoidal ectasia is a rare lesion of unknown pathogenesis. We describe the case of a 31-year-old woman who had used oral contraceptives for 10 years and was found to have abnormal liver function tests on "routine" examination. A single 9 x 5 x 4 cm hypervascular lesion was demonstrated radiographically. The hepatic immuno-diacetic acid and liver-spleen scans were normal. One subcapsular lesion was identified in the resected right hepatic lobe; it was characterized by focal marked dilatation of the sinusoidal spaces associated with rare hepatocyte necrosis and early intrasinusoidal fibrosis. The subcapsular location and the vascular nature of this wedge-shaped lesion suggest it may represent the telangiectatic precursor of a centrally scarred focal nodular hyperplasia.
authors.affiliation: Department of Pathology, McGill University, Montreal, Quebec, Canada.
authors.forename: L L
authors.initials: LL
authors.lastname: Oligny
authors.forename: J
authors.initials: J
authors.lastname: Lough
mesh_terms: D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D003276:Contraceptives, Oral / Q000009:adverse effects; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D008107:Liver Diseases / Q000175:diagnosis / Q000473:pathology*; D011859:Radiography
chemical_list: D003276:Contraceptives, Oral