Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism.
Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (approximately 30% blood loss) had decreased mean arterial blood pressures (P less than 0.05) and increased (P less than 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham-treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P less than 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.
Anderson
B O
BO
Webb-Waring Lung Institute, University of Colorado, Denver 80262.
Moore
E E
EE
Moore
F A
FA
Leff
J A
JA
Terada
L S
LS
Harken
A H
AH
Repine
J E
JE
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D008168:Lung / Q000201:enzymology / Q000473:pathology*; D008297:Male; D009504:Neutrophils / Q000201:enzymology / Q000473:pathology*; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000201:enzymology / Q000473:pathology*; D014414:Tungsten / Q000494:pharmacology; D014968:Xanthine Dehydrogenase / Q000097:blood / Q000378:metabolism; D014969:Xanthine Oxidase / Q000097:blood / Q000172:deficiency / Q000378:metabolism*
D009195:Peroxidase; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase; D014414:Tungsten