[Disorders of cerebral monoamide oxidase activity in rats after prenatal alcoholization and their correction with reduced glutathione].
Structures of the brain of rats from the offsprings of alcoholized female rats and animals given glutathione postnatally were examined for monoamine oxidase (MAO) activity by histochemistry using discrete cytospectrophotometry. A decrease of the enzyme activity in caudate nucleus neuropile, preserved up to the 60th postnatal day, an increase of the enzyme activity in neuropile of layer III of the visual cortex in 30-day-old rats from the offsprings of the alcoholized females and a lowering in layer V of the visual cortex in 60-day-old offspring were identified. There were no changes in neuropile of the sensorimotor cortex. Postnatal administration of glutathione to the animals alcoholized on an intrauterine basis resulted in complete normalization of MAO activity by the 60th postnatal day.
Kolomeets
N S
NS
Uzbekov
M G
MG
D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002421:Caudate Nucleus / Q000187:drug effects / Q000201:enzymology*; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000188:drug therapy / Q000201:enzymology*; D005978:Glutathione / Q000627:therapeutic use*; D008431:Maternal-Fetal Exchange / Q000502:physiology; D008995:Monoamine Oxidase / Q000172:deficiency*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology*; D051381:Rats; D014793:Visual Cortex / Q000187:drug effects / Q000201:enzymology*
D008995:Monoamine Oxidase; D005978:Glutathione
Narushenie aktivnosti monoaminoksidazy golovnogo mozga krys pri antinatal'noĭ alkogolizatsii i ee korrektsiia vosstanovlennym glutationom.