Cytomegalovirus homologs of cellular G protein-coupled receptor genes are transcribed.
The genome of human cytomegalovirus (HCMV) contains three genes with homology to cellular G protein-coupled receptors (GCRs). Evidence is presented here that all three HCMV GCR genes are transcribed during infection, that they are transcribed as two sets of 3'-coterminal mRNAs, and that their transcription is restricted to the late phase of infection.
Welch
A R
AR
Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
McGregor
L M
LM
Gibson
W
W
D001483:Base Sequence; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000235:genetics*; D019204:GTP-Binding Proteins / Q000235:genetics; D015870:Gene Expression; D005814:Genes, Viral; D006801:Humans; D066298:In Vitro Techniques; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic; D015678:Viral Structural Proteins / Q000235:genetics*
D009841:Oligonucleotides; D012333:RNA, Messenger; D012367:RNA, Viral; D011956:Receptors, Cell Surface; D015678:Viral Structural Proteins; D019204:GTP-Binding Proteins