Pharmacokinetics of bronchial artery infusion of mitomycin in patients with non-small cell lung cancer.
The pharmacokinetics of bronchial artery infusion of 20 mg (11.4-14.0 mg/m2) mitomycin was studied in 14 patients with non-small cell lung cancer (NSCLC). The mean elimination half-life was 34.3 min (range 6-72), and the area under the plasma concentration-time curve (AUC) was 166 ng h/ml (39-312). The mean maximum plasma drug concentration (Cmax) was 178 ng/ml (12-540) and back-extrapolated plasma drug concentration was 308 ng/ml (17-1423). The mean volume of distribution in the one-compartment model was 0.183 l/kg (0.010-0.887) and the rate constant for unchanged drug appearing in the urine was 1.91/min (0.57-7.27). There was considerable variation among individuals with respect to the pharmacokinetics of mitomycin, and the mean Cmax and AUC were lower than those reported after intravenous administration.
Shimizu
E
E
NCI-Navy Medical Oncology Branch, Bethesda, Maryland 20889-5105.
Nakamura
Y
Y
Mukai
J
J
Tani
K
K
Yamashita
T
T
Hojo
F
F
Hashimoto
Y
Y
Ogura
T
T
D001981:Bronchial Arteries; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood*; D006207:Half-Life; D006801:Humans; D007269:Injections, Intra-Arterial; D008175:Lung Neoplasms / Q000097:blood*; D008937:Mitomycins / Q000493:pharmacokinetics*
D008937:Mitomycins