Chronic imipramine "reverses" B-HT 920-induced hypomotility in rats.
B-HT 920, a selective DA autoreceptor agonist, reduced motor activity in rats. Chronic, but not acute, treatment with imipramine (IMI) reversed this effect. The mechanism by which chronic IMI reverses the B-HT 920 effect is discussed.
Serra
G
G
Department of Neuroscience, B.B. Brodie, University of Cagliari, Italy.
Collu
M
M
D'Aquila
P S
PS
De Montis
G M
GM
Gessa
G L
GL
D000818:Animals; D001381:Azepines / Q000037:antagonists & inhibitors*; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D001381:Azepines; D011954:Receptors, Dopamine; C024763:talipexole; D007099:Imipramine