[Catalepsy and hyperkinesis induced by the chronic administration of a tetrapeptide into the rat neostriatum].
The effect of bilateral intrastriatal daily microinjection of 5 and 15 micrograms of ley-enkephalin and its synthetic analog tetrapeptide during 3 weeks on behaviour, was investigated. No obvious effect was obtained after ley-enkephalin microinjections. The tetrapeptide produced obvious cataleptic status with plastic rigidity of skeletal muscles. Starting from the 2nd week of tetrapeptide microinjections, the upper arms developed a stereotyped hyperkinesis. No avoidance conditioning was possible. The findings suggest an involvement of the enkephalin neostriatal system in pathological behaviour as an analog of psychopathological disorders in humans.
Iakimovskiĭ
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D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D004743:Enkephalin, Leucine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D006948:Hyperkinesis / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D004743:Enkephalin, Leucine
Katalepsiia i giperkinez, vyzyvaemye khronicheskim vvedeniem v neostriatum krys tetrapeptida.