[Inhalation of organic solvents during the last third of pregnancy in Sprague-Dawley rats. Somatometric and cerebellar consequences in newborn animals].
Cerebellar morphogenesis as well as somatometric parameters of progenies from mothers exposed to ethyl-ether, chloroform, turpentine or thinner were registered a 24, 48 and 7 hours of age. 1. Mortality rate of 20 and 59% was observed in progenies of thinner or turpentine exposed mothers, correspondingly. 2. Delay of intrauterine growth manifested by body weight, size and cephalic diameter was evident in chloroform exposed groups (P < 0.01). 3. Cerebellar maturation delay was found in thinner or turpentine prenatally exposed litters. 4. The number of Purkinje cells was significantly reduced in ethyl-ether and chloroform exposed groups (P < 0.01). These cells were found less affected by thinner or turpentine exposure (P < 0.01).
García-Estrada
J
J
Depto. de Invest. Científica, Facultad de Med. de la Universidad de Guadalajara, Jalisco, México.
Navarro-Ruiz
A
A
Bañuelos-Pineda
J
J
Gómez
V
V
Albarrán-Rodríguez
E
E
Garzón
P
P
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000280:Administration, Inhalation; D000818:Animals; D000831:Animals, Newborn; D002508:Cephalometry; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000196:embryology / Q000473:pathology; D002725:Chloroform / Q000008:administration & dosage / Q000633:toxicity; D004986:Ether / Q000008:administration & dosage / Q000633:toxicity; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced*; D008297:Male; D008431:Maternal-Fetal Exchange; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage / Q000633:toxicity; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011689:Purkinje Cells / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley / Q000196:embryology; D012997:Solvents / Q000008:administration & dosage / Q000633:toxicity*; D014425:Turpentine / Q000008:administration & dosage / Q000633:toxicity
D014677:Pharmaceutical Vehicles; D012997:Solvents; D004986:Ether; D002725:Chloroform; D014425:Turpentine
Inhalación de solventes orgánicos durante el último tercio del embarazo de ratas Sprague-Dawley. Consecuencias somatométricas y cerebelosas en neonatos.