[The effect of practolol and atenolol on the lysosomal enzyme activity of the ventricular myocardium of rats].
The influence of cardioselective beta-blockers, practolol and atenolol, on acid phosphatase, acid deoxyribonuclease, cathepsin D, beta-glucosidase and beta-galactosidase activities was studied in homogenates of intact rat ventricular myocardium. In the presence of drugs (1 x 10(-9)-1 x 10(-5) M) the activities of acid phosphatase, cathepsin D, beta-glucosidase and beta-galactosidase tended to diminish but the activity of acid deoxyribonuclease tended to increase. Some differences in the influence of drugs on the enzyme activities were removed by prolongation of preincubation of homogenates with drugs. It is supposed that the mechanism of influence of beta-blockers on lysosomes of the intact rat ventricular myocardium in conditions of this study includes the specific drug binding to beta-adrenergic receptors situated on lysosomes.
Sergeev
P V
PV
Sysoliatina
N A
NA
D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects / Q000201:enzymology; D066298:In Vitro Techniques; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D011217:Practolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D011943:Receptors, Adrenergic, beta; D001262:Atenolol; D011217:Practolol
Vliianie praktolola i atenolola na aktivnost' lizosomal'nykh fermentov miokarda zheludochkov krys.