Does bulk damage to DNA explain the cytostatic and cytotoxic effects of topoisomerase II inhibitors?
Gewirtz
D A
DA
Department of Pharmacology/Toxicology, Medical College of Virginia, Richmond 23298.
D000677:Amsacrine / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D005047:Etoposide / Q000494:pharmacology; D006801:Humans; D013713:Teniposide / Q000494:pharmacology; D059005:Topoisomerase II Inhibitors
D000970:Antineoplastic Agents; D059005:Topoisomerase II Inhibitors; D000677:Amsacrine; D005047:Etoposide; D004247:DNA; D013713:Teniposide