[Experimental testicular fibrosis and atrophy induced by intratesticular propylene glycol injection].
Fifty-four 15 day old male Wistar rats were given single intratesticular injection of experimental preparations which contained formaldehyde, xylocaine and epinephrine diluted in propylene glycol (FXEP); xylocaine in propylene glycol (XP): epinephrine in propylene glycol (EP) propylene glycol (P); formaldehyde in 0.1 M phosphate buffer solution (F); an one control group. The group of rats that were given FXEP underwent testicular weight reduction; body weight and size were not affected. Also the treatment with P produced atrophy and fibrosis in testis and a more severe testicular weight reduction. The sclerosing effect of P treatment was more satisfactory than treatment with FXEP, and apparently no one affected body weight and size, thus, this could be a safe, easy and inexpensive method for non surgical castration.
Ramírez-Herrera
M A
MA
Facultad de Ciencias Biológicas, Universidad de Guadalajara, Jalisco, México.
Gabriel Ortíz
G
G
D000818:Animals; D001284:Atrophy; D001835:Body Weight; D004338:Drug Combinations; D004837:Epinephrine / Q000494:pharmacology; D005355:Fibrosis; D005557:Formaldehyde / Q000494:pharmacology; D007267:Injections; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012597:Sclerosing Solutions / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D004338:Drug Combinations; D011409:Propylene Glycols; D012597:Sclerosing Solutions; D005557:Formaldehyde; D019946:Propylene Glycol; D008012:Lidocaine; D004837:Epinephrine
Atrofia y fibrosis testicular experimentalmente inducida por inyección intratesticular de propilenglicol.