Identification of a novel class of highly potent sigma ligands related to the kappa-selective agonist U50,488.
Radesca
L A
LA
Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892.
deCosta
B R
BR
Bowen
W D
WD
DiPaolo
L J
LJ
Rice
K C
KC
D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000700:Analgesics; D000818:Animals; D007276:Injections, Intraventricular; D008024:Ligands; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D011957:Receptors, Opioid / Q000187:drug effects*; D017480:Receptors, sigma; D013329:Structure-Activity Relationship
D000700:Analgesics; D008024:Ligands; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017480:Receptors, sigma; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer