Increased numbers of sodium channels form along demyelinated axons.
Sodium channels, which are largely localized to the nodes of Ranvier in myelinated axons, appear to form new distributions along demyelinated axons. In this study a sensitive radioimmunoassay (RIA) was used to examine the changes in the total number of sodium channels that occur in nerves experimentally demyelinated in vivo with doxorubicin (adriamycin). The results clearly illustrate the development of an increased number of sodium channels during demyelination, suggesting that this process is associated with the formation of new sodium channels.
England
J D
JD
Department of Neurology, University of Colorado School of Medicine, Denver 80262.
Gamboni
F
F
Levinson
S R
SR
D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism*; D004317:Doxorubicin / Q000494:pharmacology*; D004557:Electric Organ / Q000502:physiology; D004593:Electrophorus; D009186:Myelin Sheath / Q000187:drug effects / Q000502:physiology*; D011863:Radioimmunoassay; D011901:Ranvier's Nodes / Q000187:drug effects / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000378:metabolism
D002352:Carrier Proteins; D015222:Sodium Channels; C023790:tetrodotoxin-binding protein; D013779:Tetrodotoxin; D004317:Doxorubicin