title: Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma.
abstract: Thirty-one patients were diagnosed by morphologic and immunophenotypic features as having primary Ki-1 anaplastic large-cell lymphoma (Ki-1 ALCL). the median age was 35 years (range, 4 months to 78 years); the male:female ratio was 18:13. B symptoms were observed in 13 patients. Peripheral adenopathy was present in 26 patients, while mediastinal adenopathy occurred in five. There was extranodal disease in 13 patients; the most common extranodal site was skin with seven affected. Seventeen patients had stage III/IV disease. Immunophenotypes were T cell in 24 patients and B cell in four patients; immunophenotype could not be determined in three patients. Cytogenetic abnormalities in chromosomes 2, 5, and 7 were detected in three patients. Although therapy was heterogeneous, the actuarial 2-year survival was 73%. Two-year disease-free survival was 39% for all patients; for stages I and II, it was 62% compared with 20% for stages III and IV (P = .001). Complete remission (CR) occurred in 21 of 23 patients receiving combination chemotherapy; however, nine relapses, including six of seven stage IV patients, occurred within 21 months of diagnosis. Preliminary observations suggest that Ki-1 ALCL may have a quiescent phase in the rare patient with only localized skin disease. However, the disease generally behaves as an intermediate- to high-grade lymphoma, and patients with Ki-1 ALCL should receive curative-intent combination chemotherapy.
authors.affiliation: Department of Medicine, Vanderbilt University, Nashville, TN.
authors.forename: J P
authors.initials: JP
authors.lastname: Greer
authors.forename: M C
authors.initials: MC
authors.lastname: Kinney
authors.forename: R D
authors.initials: RD
authors.lastname: Collins
authors.forename: K E
authors.initials: KE
authors.lastname: Salhany
authors.forename: S N
authors.initials: SN
authors.lastname: Wolff
authors.forename: J D
authors.initials: JD
authors.lastname: Hainsworth
authors.forename: J M
authors.initials: JM
authors.lastname: Flexner
authors.forename: R S
authors.initials: RS
authors.lastname: Stein
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000708:Anaplasia; D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D017730:Ki-1 Antigen; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen