title: Assessment of the genotoxic potential of Caramel Colour I in four short-term tests.
abstract: A battery of three short-term tests in vitro and one in vivo was used to determine the genotoxicity of Caramel Colour I. The results of the bacterial mutation assay, using five strains of Salmonella typhimurium, and the mouse micronucleus assay in vivo showed no evidence of genotoxic activity. Results from both the cytogenetics assay in vitro, using CHO cells, and the mouse lymphoma assay indicated that there was some genotoxic activity associated with Caramel Colour I but only in the absence of S-9 and at very high dose levels.
authors.affiliation: Department of Mutagenesis and Cell Biology, Huntingdon Research Centre, UK.
authors.forename: K
authors.initials: K
authors.lastname: Adams
authors.forename: J A
authors.initials: JA
authors.lastname: Allen
authors.forename: P C
authors.initials: PC
authors.lastname: Brooker
authors.forename: E
authors.initials: E
authors.lastname: Jones
authors.forename: R J
authors.initials: RJ
authors.lastname: Proudlock
mesh_terms: D000818:Animals; D016466:CHO Cells; D002182:Candy; D002241:Carbohydrates; D002875:Chromosomes / Q000187:drug effects*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005505:Food Coloring Agents / Q000633:toxicity*; D005796:Genes / Q000187:drug effects*; D008223:Lymphoma; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009930:Organic Chemicals; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D002241:Carbohydrates; D005505:Food Coloring Agents; D009153:Mutagens; D009930:Organic Chemicals; C569050:caramel coloring