[Acute pancreatitis and valproic acid].
An 11 year-old epileptic boy, treated with valproic acid developed after 11 months on therapy a severe acute pancreatitis. Pancreatitis recurred 18 months after re-exposure to the same drug. Twenty-four cases of valproic-acid induced acute pancreatitis have been reported in the literature. However, it remains a major anticonvulsant drug whose tolerance is usually excellent. This complication, although exceptional needs to be known so that the treatment can be stopped in due-time if not tolerated or to avoid eventual recurrence.
Kayemba Kay's Kabangu
S
S
Département de pédiatrie, centre hospitalier général, Chambéry, France.
Bovier Lapierre
M
M
Jalaguier
E
E
D000208:Acute Disease; D002648:Child; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D014635:Valproic Acid
Pancréatite aiguë et acide valproïque.