title: [Clinical and pathogenetic observations on children with chronic mononucleosis].
abstract: Epstein-Barr virus is seldom the causative agent of a prolonged atypical illness, known as chronic mononucleosis syndrome, characterized by a persistent pattern of clinical manifestations and by a defective immune response to specific viral antigens. This paper refers about 6 children for whom clinical and serological findings suggest the chronic Epstein-Barr virus infection. The authors believe that this chronic state might be explained by the unusual antibody pattern to EBV virus, with the persistent presence of anti-EA and the absence of anti-EBNA titers, expression of a reduced EBV-specific cytotoxic T cell activity.
authors.affiliation: Clinica Pediatrica R. di Palermo, Università di Palermo, Italia.
authors.forename: F
authors.initials: F
authors.lastname: Cataldo
authors.forename: P
authors.initials: P
authors.lastname: Ammatuna
authors.forename: L
authors.initials: L
authors.lastname: Bellia
authors.forename: F
authors.initials: F
authors.lastname: Sammartano
authors.forename: M
authors.initials: M
authors.lastname: Violante
authors.forename: A
authors.initials: A
authors.lastname: Albeggiani
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D015673:Fatigue Syndrome, Chronic / Q000276:immunology* / Q000382:microbiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D000914:Antibodies, Viral; D007136:Immunoglobulins
vernacular_title: Rilievi clinico-patogenetici su bambini con mononucleosi cronica.