[Peroxide modification of skeletal muscle sarcoplasmic reticulum in antioxidant deficiency and under the action of ionol. I. Calcium transport into sarcoplasmic reticulum membranes].
It is shown that in case of antioxidant insufficiency (AOI) activation of NADPH- and ascorbate-dependent lipid peroxidation (LPO) in sarcoplasmic reticulum (SR) of skeletal muscles proceeds 1.7 and 4.1 times faster, respectively. Activation of lipid peroxidation in AOI leads to damage of Ca2+ transport processes in SR of skeletal muscles. Under these conditions ATP-dependent accumulation of 45Ca (by 88%) and Ca(2+)-ATPase (by 14%) activity in SR of skeletal muscles falls. In case of AOI a significant disturbance of passive Ca2+ transport in SR of skeletal muscles takes place, being characterized by an increased passive 45Ca output from vesicles due to breakage of the biomembrane permeability as a result of lipid peroxidation of membranes. Treatment of animals with ionol, a synthetic antioxidant, causes a decrease of activated NADPH- and ascorbate-dependent LPO in SR of skeletal muscles and stabilization of Ca2+ transport processes.
Gubskiĭ
Iu I
IuI
Zadorina
O V
OV
Fedorov
A N
AN
Bogdanova
L A
LA
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D000975:Antioxidants; D001692:Biological Transport; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D015227:Lipid Peroxidation; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010545:Peroxides / Q000494:pharmacology*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism
D000975:Antioxidants; D010545:Peroxides; D002084:Butylated Hydroxytoluene; D009249:NADP; D000255:Adenosine Triphosphate; D000252:Calcium-Transporting ATPases; D002118:Calcium
Perekisnaia modifikatsiia sarkoplazmaticheskogo retikuluma skeletnykh myshts pri antioksidantnoĭ nedostatochnosti i deĭstvii iionola. I. Transport Ca(2+) v membranakh sarkoplasmaticheskogo retikuluma.