[Vitamin D and the skin: new aspects and perspectives].
Vitamin D (calciferol) is under clinical investigation for the treatment of psoriasis. Vitamin D was previously solely regarded as a key substance in hormonal calcium homeostasis, a view that is no longer tenable. The human receptor for the biologically active metabolite 1,25-dihydroxyvitamin-D3 was cloned in 1988. Sequence analyses revealed that it was a member of the nuclear steroid hormone receptor family. This family of gene-regulatory DNA-binding proteins includes the oestrogen, progesterone, glucocorticoid, mineralocorticoid, thyroxine (T-3) and retinoic acid receptors. Vitamin D receptors have been identified in a variety of tissues primarily unrelated to calcium metabolism. The skin and the immune system are some of the most interesting new targets. In vitro 1,25-dihydroxyvitamin-D3 inhibits proliferation and induces differentiation of keratinocytes. Furthermore, this hormone has potent immunomodulatory functions.
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Hautklinik Heinrich-Heine-Universität Düsseldorf.
D002117:Calcitriol / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000235:genetics / Q000502:physiology*; D012867:Skin / Q000503:physiopathology*; D012871:Skin Diseases / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D014807:Vitamin D / Q000235:genetics / Q000502:physiology*
D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; D014807:Vitamin D; D002117:Calcitriol
Vitamin D und die Haut: neue Aspekte und Perspektiven.