[Serotonin receptors blocker ketanserin in the combined therapy of patients with chronic obstructive bronchitis].
The addition of ketanserin (a blocker of serotonin S2-receptors) to treatment of bronchial obstruction is shown to lower plasma and platelet concentrations of serotonin, leukotriene B4 level in the lavage fluid, to shift prostacyclin-thromboxane balance to the side of prostacyclin. In 40 patients with chronic obstructive bronchitis treated, the above changes were associated with persistent clinical response, a decrease of bronchial obstruction, being the most profound in a group of patients with chronic catarrhal bronchitis.
Efimov
V V
VV
Blazhko
V I
VI
Voeĭkdova
L S
LS
Liashenko
M M
MM
Bondar'
T N
TN
D000328:Adult; D001991:Bronchitis / Q000188:drug therapy* / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000378:metabolism; D002908:Chronic Disease; D011464:Epoprostenol / Q000378:metabolism; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000494:pharmacology / Q000627:therapeutic use*; D007975:Leukotriene B4 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011985:Receptors, Serotonin / Q000378:metabolism; D012129:Respiratory Function Tests; D012701:Serotonin / Q000097:blood; D012702:Serotonin Antagonists; D013928:Thromboxane A2 / Q000378:metabolism
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D007975:Leukotriene B4; D012701:Serotonin; D013928:Thromboxane A2; D007650:Ketanserin; D011464:Epoprostenol
Primenenie blokatora serotoninovykh retseptorov ketanserina v kompleksnom lechenii bol'nykh khronicheskim obstruktibnym bronkhitom.