[Mechanism of protective effects of ouren-gedoku-to and san'ou-syashin-to on the gastric mucosa].
Ouren-Gedoku-To (OGT) and San'ou-Syashin-To (SST), traditional Chinese prescriptions, have been used to treat peptic ulcer. In order to elucidate the mechanism of the protective effects of OGT and SST on the gastric mucosa, we studied their effects on gastric mucosal lesions, ion permeability and prostaglandin synthesis using ulcer experimentally induced in rats by saturation with acidic test solution after taurocholate treatment. Both OGT and SST inhibited taurocholate-induced gastric mucosal lesions in a dose-related manner. These prescriptions dose-dependently inhibited not only the increase of hydrogen and sodium ion net fluxes but also possible hydrogen ion back diffusion into the gastric mucosa during saturation with acidic test solution. SST induced a significant increase in gastric mucosal prostaglandins synthesized from 14C labeled arachidonate. These results suggest that both OGT and SST by strengthening the gastric mucosal barrier demonstrate their protective effects on the gastric mucosa and that this effect of SST is attributable to the increased ability of the gastric mucosa to synthesize prostaglandin.
Suenaga
T
T
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Shirakawa
T
T
Harada
N
N
Tao
C
C
Yamasaki
M
M
Komatsu
H
H
Matsumoto
N
N
Kida
M
M
Kawamoto
Y
Y
Murakami
Y
Y
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001599:Berberine / Q000494:pharmacology*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D010437:Peptic Ulcer / Q000517:prevention & control; D010936:Plant Extracts; D011453:Prostaglandins / Q000096:biosynthesis; D011522:Protons; D051381:Rats; D011919:Rats, Inbred Strains; D013634:Tannins / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D010936:Plant Extracts; D011453:Prostaglandins; D011522:Protons; D013634:Tannins; C061676:oren gedoku to; C062798:sannoshashinto; D001599:Berberine