title: Synthesis and antienzymic activity of two new angiotensin converting enzyme inhibitors.
abstract: Two new analogs of captopril were synthesized. Inhibition of angiotensin converting enzyme (ACE) by these compounds in vitro and in vivo was determined using fluorimetric method. The obtained compounds were much weaker ACE inhibitors than captopril.
authors.affiliation: Institute for Drug Research and Control, Warszawa, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Dudkiewicz
authors.forename: T
authors.initials: T
authors.lastname: Suska
authors.forename: J
authors.initials: J
authors.lastname: Tautt
authors.forename: R
authors.initials: R
authors.lastname: Paruszewski
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013050:Spectrometry, Fluorescence
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril; D007703:Peptidyl-Dipeptidase A