Molecular target size of the vanilloid (capsaicin) receptor in pig dorsal root ganglia.
The size of the vanilloid receptor was examined by high-energy radiation inactivation analysis of the binding of [3H]resiniferatoxin to pig dorsal root ganglion membranes; it was found to be 270 +/- 25 kDa. This value most likely represents the size of a receptor complex rather than of an individual subunit. Other ligand-gated cation channel complexes have reported molecular weights in this range, e.g. 300 kDa for the acetylcholine receptor.
Szallasi
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Molecular Mechanisms of Tumor Promotion Section, National Cancer Institute, Bethesda, MD 20892.
Blumberg
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PM
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002211:Capsaicin / Q000378:metabolism*; D004224:Diterpenes / Q000378:metabolism; D005727:Ganglia, Spinal / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects; D008970:Molecular Weight; D017981:Receptors, Neurotransmitter / Q000737:chemistry*; D011984:Sensory Receptor Cells / Q000737:chemistry; D013552:Swine; D013570:Synaptic Membranes / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects
D004224:Diterpenes; D017981:Receptors, Neurotransmitter; C024353:resiniferatoxin; D000110:Acetylcholinesterase; D002211:Capsaicin