Endocytosis and signals for internalization.
The most important recent advance in the field of endocytosis has been the identification of the internalization signals of several constitutively recycling receptors. Common structural features and chemistry of internalization sequences have been defined, and an exposed tight turn has been implicated as the conformational recognition motif for endocytosis.
Trowbridge
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Salk Institute, San Diego, California.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008360:Mannosephosphates / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D015394:Molecular Structure; D011487:Protein Conformation; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011973:Receptors, LDL / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism*; D015398:Signal Transduction; D014168:Transferrin / Q000378:metabolism
D008077:Lipoproteins, LDL; D008360:Mannosephosphates; D008562:Membrane Glycoproteins; D017527:Receptor, IGF Type 2; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; D011990:Receptors, Transferrin; D014168:Transferrin; C027693:mannose-6-phosphate