[Anti-idiotypic antibodies to the herpes simplex type-1 virus neutralize the virus' infectious activity].
Immunochemical study of blood sera from mice immunized with rabbit immunoglobulins (AT1) to herpes simplex virus type I (HSV-I) detected antiidiotypic antibodies AT2 in five of them (antiID). The affinity-purified antiID were shown to induce in syngeneic mice production of antibody (AT3) interacting with HSV-I antigen. In vitro, antiID (AT3) were shown to neutralize the virus activity. Analysis of the results suggests that the antiID imitate the antigenic properties of HSV-I and can induce specific immune response.
Kushch
A A
AA
Posevaia
T A
TA
Simonov
V I
VI
Daniliuk
O S
OS
Barinskiĭ
I F
IF
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology* / Q000302:isolation & purification; D002846:Chromatography, Affinity; D003168:Complement Fixation Tests; D007114:Immunization; D007124:Immunoenzyme Techniques; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests / Q000379:methods; D011817:Rabbits; D018139:Simplexvirus / Q000276:immunology* / Q000472:pathogenicity
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral
Antiidiotipicheskie antitela k virusu prostogo gerpesa tipa 1 neĭtralizuiut infektsionnuiu aktivnost' virusa.