[Alpha1 desensitization of the heart during adaptation to stress].
Results of the experiments evidence that a combination of three factors, limiting the Ca2+ concentration increase in myocardial cell, can play a role in the cardioprotective effect of adaptation of rats to short-term immobilization stress (every second day for a month) are presented. Those factors are as follows: desensitization of alpha 1-adrenoreceptors, M-cholinoreceptors up-regulation and reduced number of voltage-dependent Ca2+ channels in the myocardial membranes.
Meerson
F Z
FZ
Kopylov
Iu N
IuN
Baldenkov
G N
GN
D000222:Adaptation, Physiological / Q000502:physiology; D000223:Adaptation, Psychological / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D008297:Male; D008960:Models, Psychological; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*; D013997:Time Factors
D015220:Calcium Channels; D011942:Receptors, Adrenergic, alpha; D002118:Calcium
Alpha1-desensitizatsii serdtsa pri adaptatsii k stressovym vozdeĭstviiam.