title: Effects of dietary fiber supplementation on glycemic control in dogs with alloxan-induced diabetes mellitus.
abstract: The effect of a high insoluble-fiber (IF) diet containing 15% cellulose in dry matter, high soluble-fiber (SF) diet containing 15% pectin in dry matter, and low-fiber (LF) diet on glycemic control in 6 dogs with alloxan-induced insulin-dependent diabetes mellitus was evaluated. Each diet contained greater than 50% digestible carbohydrate in dry matter. A crossover study was used with each dog randomly assigned to a predetermined diet sequence. Each dog was fed each diet for 56 days. Caloric intake was adjusted weekly as needed to maintain each dog within 1.5 kg of its body weight measured prior to induction of diabetes mellitus. All dogs were given pork lente insulin and half of their daily caloric intake at 12-hour intervals. Mean (+/- SEM) daily caloric intake was significantly (P less than 0.05) less when dogs consumed the IF diet vs the SF and LF diets (66 +/- 3 kcal/kg, 81 +/- 5 kcal/kg, and 79 +/- 4 kcal/kg, respectively). Serum alkaline phosphatase activity was significantly (P less than 0.05) higher when dogs consumed the LF diet vs the IF and SF diets (182 +/- 37 IU/L, 131 +/- 24 IU/L, and 143 +/- 24 IU/L, respectively). Mean postprandial plasma glucose concentration measured every 2 hours for 24 hours, beginning at the time of the morning insulin injection, was significantly (P less than 0.05) lower at most blood sampling times in dogs fed IF and SF diets, compared with dogs fed the LF diet.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
authors.forename: R W
authors.initials: RW
authors.lastname: Nelson
authors.forename: S L
authors.initials: SL
authors.lastname: Ihle
authors.forename: L D
authors.initials: LD
authors.lastname: Lewis
authors.forename: S K
authors.initials: SK
authors.lastname: Salisbury
authors.forename: T
authors.initials: T
authors.lastname: Miller
authors.forename: V
authors.initials: V
authors.lastname: Bergdall
authors.forename: G D
authors.initials: GD
authors.lastname: Bottoms
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000821:Animal Feed; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy* / Q000188:drug therapy; D003922:Diabetes Mellitus, Type 1 / Q000178:diet therapy / Q000188:drug therapy / Q000662:veterinary*; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000178:diet therapy* / Q000188:drug therapy; D004285:Dogs; D002149:Energy Intake; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D012995:Solubility
chemical_list: D000469:Alkaline Phosphatase; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D006442:Glycated Hemoglobin; D007328:Insulin