title: The second-generation antihistamines. What makes them different?
abstract: Physicians often are faced with the decision of whether to prescribe a drug for its positive therapeutic effects or avoid prescribing it because of unacceptable side effects. This dilemma can sometimes be eased by keeping current on new therapeutic options as they become available. The authors provide a useful update on the state of the art in antihistamine therapy.
authors.affiliation: Department of Internal Medicine, University of California, School of Medicine, Davis.
authors.forename: B T
authors.initials: BT
authors.lastname: Ryhal
authors.forename: M P
authors.initials: MP
authors.lastname: Fletcher
mesh_terms: D016589:Astemizole; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D001562:Benzimidazoles / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D017332:Cetirizine; D003533:Cyproheptadine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D004502:Education, Medical, Continuing; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology; D006967:Hypersensitivity / Q000188:drug therapy*; D017336:Loratadine; D016593:Terfenadine
chemical_list: D001559:Benzhydryl Compounds; D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D003533:Cyproheptadine; D006919:Hydroxyzine; D017336:Loratadine; D016593:Terfenadine; D016589:Astemizole; D017332:Cetirizine