[Role of microtubule cytoskeletons in the transduction of growth signals].
Attention has recently been paid to the role of microtubules in the transduction of growth signals, which has recently been establishing as a molecular function of microtubule cytoskeletons. The analysis of pathways in the signal transductions which are initiated by the activation of tyrosine-specific phosphorylation of growth factor receptors now seems to come to deal with events deeper inside the cell. It was recently found that MAP kinase which preferentially phosphorylates microtubule-associated protein 2 is largely activated at the G0/G1 transition by any of various growth stimuli. The kinase is also activated at the G2/M transition in the downstream of MPF (cdc2 kinase). Furthermore, it was suggested that a GTP-binding protein (51-kD protein) in the centrosome plays a role in the microtubule signalling at the onset of mitosis. This minireview discusses possible signalling pathway from the activation of tyrosine-specific protein kinase of the growth factor receptor to the initiation of mitosis.
Sakai
H
H
Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo.
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002478:Cells, Cultured; D066246:ErbB Receptors / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000378:metabolism / Q000502:physiology; D008870:Microtubules / Q000502:physiology*; D008938:Mitosis; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
D008869:Microtubule-Associated Proteins; D011494:Protein Kinases; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019204:GTP-Binding Proteins