title: [Proline hydroxylase (hPH) as marker of hepatic fibrosis in beta thalassemia].
abstract: Forty-four polytransfused thalassemic patients were considered to evaluate hPH enzyme, involved in collagen synthesis. The aim of this investigation was to verify the usefulness of such assay in the follow-up of liver damage in thalassaemic patients. The patients were separated into two groups: one group with normal transaminase activity and another one with pathological values from more than two years. A group of 20 healty children was chosen for the control values of enzymatic activity. In all patients HCV-Ab was determined. Results obtained confirm the role of viral liver infection in inducing fibrosis in polytransfused thalassaemic patients and suggest the possibility to use hPH assay in their follow-up.
authors.affiliation: Clinica Pediatrica dell'Università di Catania, Italia.
authors.forename: S
authors.initials: S
authors.lastname: Leonardi
authors.forename: E
authors.initials: E
authors.lastname: Avola
authors.forename: R
authors.initials: R
authors.lastname: Rapisarda
authors.forename: W
authors.initials: W
authors.lastname: La Delfa
authors.forename: S
authors.initials: S
authors.lastname: Musumeci
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000201:enzymology* / Q000209:etiology; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000097:blood*; D013789:Thalassemia / Q000097:blood / Q000150:complications*
chemical_list: D015415:Biomarkers; D011393:Procollagen-Proline Dioxygenase
vernacular_title: La prolinaidrossilasi (hPH) come marker di fibrosi epatica nella beta talassemia.