title: Gene expression of fibroblast growth factor receptors in the tissues of human gliomas and meningiomas.
abstract: Northern blot analysis showed transcripts of two types of the fibroblast growth factor (FGF) receptor genes, flg and bek, in almost all the tissues samples of 18 human gliomas and 22 human meningiomas, which produced abundant basic and/or acidic FGF. From immunohistochemistry, FGF receptors were expressed in the tumor cells of a glioma and a meningioma. RNA expression of these FGF receptors was also detectable in normal human brains and normal bovine meninges. The expression level of either FGF receptor gene was not significantly different between tumor tissues and normal tissues.
authors.affiliation: Department of Molecular Virology, Kyoto University, Japan.
authors.forename: J A
authors.initials: JA
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Suzui
authors.forename: Y
authors.initials: Y
authors.lastname: Yasuda
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: M
authors.initials: M
authors.lastname: Jaye
authors.forename: M
authors.initials: M
authors.lastname: Fukumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Oda
authors.forename: H
authors.initials: H
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Hatanaka
mesh_terms: D015152:Blotting, Northern; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D000091344:Filaggrin Proteins; D005910:Glioma / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000378:metabolism; D008579:Meningioma / Q000235:genetics* / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D011956:Receptors, Cell Surface / Q000235:genetics*; D017468:Receptors, Fibroblast Growth Factor
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D012334:RNA, Neoplasm; D011956:Receptors, Cell Surface; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors