Isolation and characterization of herpes simplex virus resistant to nucleoside analogs.
Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2'-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2'-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient 3 1/2 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.
Katz
E
E
Department of Virology, Hadassah Medical School, Hebrew University, Jerusalem, Israel.
Rosenblat
O
O
Pisanty
S
S
D000212:Acyclovir / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D004279:DNA, Viral / Q000187:drug effects; D004352:Drug Resistance, Microbial; D006560:Herpes Labialis / Q000382:microbiology; D006801:Humans; D007065:Idoxuridine / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000302:isolation & purification; D013937:Thymidine Kinase / Q000378:metabolism
D004279:DNA, Viral; D013937:Thymidine Kinase; D007065:Idoxuridine; D000212:Acyclovir