title: Inhibitory effects of 3-nitro-2,4,6-trihydroxybenzamides on Epstein-Barr virus early antigen induction.
abstract: Inhibitory effects of a series of 3-nitro-2,4,6-trihydroxybenzamides on Epstein-Barr virus early antigen (EBV-EA) induction were examined using Raji cells. Some of the tested compounds showed highly inhibitory activity, the N-octyl amide derivative being the most active among them. These results suggest the possibility that 3-nitro-2,4,6-trihydroxybenzamides might be listed as novel inhibitors of tumor promotion.
authors.affiliation: Life Science Research Laboratory, Japan Tobacco Inc., Yokohama.
authors.forename: I
authors.initials: I
authors.lastname: Honda
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: M
authors.initials: M
authors.lastname: Kozuka
authors.forename: K
authors.initials: K
authors.lastname: Yoneyama
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: A
authors.initials: A
authors.lastname: Iwashima
authors.forename: M
authors.initials: M
authors.lastname: Shibagaki
authors.forename: M
authors.initials: M
authors.lastname: Noma
authors.forename: N
authors.initials: N
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000956:Antigens, Viral / Q000096:biosynthesis*; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000276:immunology; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D010696:Phloroglucinol