title: Conversion of acyclic nucleoside phosphonates to their diphosphate derivatives by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.
authors.affiliation: Rega Institute for Medical Research, K.U. Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000378:metabolism*; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D001711:Biotransformation; D004926:Escherichia coli / Q000201:enzymology; D007700:Kinetics; D063065:Organophosphonates / Q000378:metabolism; D012268:Ribose-Phosphate Pyrophosphokinase / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D063065:Organophosphonates; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D012268:Ribose-Phosphate Pyrophosphokinase; D000225:Adenine