A new antitumor substance BE-13793C, produced by a streptomycete. Taxonomy, fermentation, isolation, structure determination and biological activity.
A new antitumor substance, BE-13793C, which has topoisomerase inhibitory activity was isolated from the culture broth of a strain of actinomycetes. The producing strain, BA13793, isolated from a soil sample collected in Seto, Aichi Prefecture, Japan, has a resemblance to Streptoverticillium mobaraense. The active principle was extracted from the mycelium of strain BA13793 with methanol and purified by Sephadex LH-20 column chromatography. BE-13793C showed strong inhibitory activity against topoisomerases I and II and inhibited the growth of doxorubicin-resistant or vincristine-resistant P388 murine leukemia cell lines, as well as their parent P388 cell line.
Kojiri
K
K
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
Kondo
H
H
Yoshinari
T
T
Arakawa
H
H
Nakajima
S
S
Satoh
F
F
Kawamura
K
K
Okura
A
A
Suda
H
H
Okanishi
M
M
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D002227:Carbazoles; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D007939:Leukemia L1210 / Q000201:enzymology; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009368:Neoplasm Transplantation; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D013306:Streptomycetaceae / Q000145:classification / Q000378:metabolism*; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D002227:Carbazoles; D007211:Indoles; D011758:Pyrroles; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; C070538:BE 13793C