Regional localization of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) uptake: mismatch between its uptake and neurotoxic sites.
Three to 24 h following intraventricular injections of radioactive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the rat, accumulations of radiolabel were widely detected, in varying degree, over neuronal perikarya in motor-related structures below the midbrain. Pretreatment with the monoamine oxidase B inhibitor pargyline largely eliminated the perikaryal radiolabeling in the substantia nigra, dorsal raphe and cerebellum, leaving that in the other regions intact. These results indicate that there exists a certain mismatch between MPTP uptake and neurotoxic sites, and that invulnerable cells can accumulate MPTP without being converted to its major active metabolite 1-methyl-4-phenylpyridine (MPP+).
Takada
M
M
Department of Anatomy, University of Toronto, Ont., Canada.
Campbell
K J
KJ
Hattori
T
T
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D008636:Mesencephalon / Q000033:anatomy & histology / Q000378:metabolism; D009046:Motor Neurons / Q000187:drug effects / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism*
D011726:Pyridinium Compounds; D011950:Receptors, Cholinergic; C026560:1-(4-methoxyphenyl)pyridinium; D010293:Pargyline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine