title: [Monoclonal antibodies to human small-cell lung cancer].
abstract: Murine monoclonal antibodies to human small cell lung cancer (SCLC) have been developed and partially characterized. Primary hybridoma clones were screened in the indirect immunofluorescence assay (IFA) on alive H417 cells. Then five clones (IgG1, IgG2a, IgG3 and IgM) non-reactive with normal human bone marrow cells and positively reactive with SCLC tumors were selected. The H417.3 antibody is directed against 47-50kD surface antigens of H417 cells. The antibodies are supposed to be applied for the immunodetection of SCLC metastases to bone marrow and immunotoxin preparations.
authors.forename: M A
authors.initials: MA
authors.lastname: Goncharskaia
authors.forename: I M
authors.initials: IM
authors.lastname: Rutkevich
authors.forename: A G
authors.initials: AG
authors.lastname: Tonevitskiĭ
authors.forename: N F
authors.initials: NF
authors.lastname: Orel
authors.forename: A V
authors.initials: AV
authors.lastname: Vasil'ev
authors.forename: N I
authors.initials: NI
authors.lastname: Perevodchikova
authors.forename: E B
authors.initials: EB
authors.lastname: Mechetner
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000276:immunology; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D005455:Fluorescent Antibody Technique; D006801:Humans; D007159:Immunologic Tests; D000922:Immunotoxins / Q000096:biosynthesis; D008175:Lung Neoplasms / Q000175:diagnosis / Q000276:immunology*; D051379:Mice
chemical_list: D000911:Antibodies, Monoclonal; D000922:Immunotoxins
vernacular_title: Monoklonal'nye antitela k melkokletochnomu raku legkogo cheloveka.