Changes in phosphatases and lipids following scrotal gamma irradiation in adult rat testis.
Effects of localized low (2.5 Gy) and high (10 Gy) levels of gamma irradiation on the testis of albino rats were studied. A marked increase in the testicular total lipid, phospholipid and cholesterol content was observed at all post-treatment intervals except at 16 weeks where the contents decreased. A significant decrease in the activity of acid phosphatase/g of testis was seen at both the doses, the minimum value being at 4 weeks. The decrease in acid phosphatase activity is correlated with the state of germ cell population in seminiferous tubule which is found to be depleted at 4 week interval. The alkaline phosphatase activity/g testis however, showed a significant increase, the maximum being at 4 weeks post-treatment. Thereafter, the values of the enzyme activity showed a slight recovery at 16 weeks post-irradiation. ATPase activity increased initially followed by a significant decrease at all post-treatment intervals.
Nehru
B
B
Department of Biophysics, Panjab University, Chandigarh, India.
Tiwari
M
M
Kaul
A
A
Bansal
M R
MR
D000818:Animals; D005720:Gamma Rays; D050356:Lipid Metabolism; D008297:Male; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D051381:Rats; D013737:Testis / Q000378:metabolism / Q000528:radiation effects*
D010744:Phosphoric Monoester Hydrolases