Phase I trial of the murine monoclonal anti-GD2 antibody 14G2a in metastatic melanoma.
In a phase I trial, 12 patients with GD2 antigen-positive metastatic melanoma received the murine anti-GD2 monoclonal antibody 14G2a. The monoclonal antibody was administered in four doses over an 8-day period with total dose ranging from 10 to 120 mg. All patients receiving greater than 10 mg of 14G2a experienced transient abdominal/pelvic pain during the antibody infusion. Five patients had a delayed extremity pain syndrome following the third and fourth antibody infusion. Four of the five patients developed neurological toxicity, including two patients with significant although reversible motor neuropathy. Two of the patients developed hyponatremia secondary to a syndrome of inappropriate antidiuretic hormone. All 12 patients developed high levels of human anti-14G2a antibody. The plasma half-life of 14G2a was 42 +/- 6 (SD) h. One patient each had a partial response, mixed response, and stable disease, respectively. The very modest antitumor activity accompanied by dose-limiting neurological toxicity at total doses greater than 80 mg may restrict the clinical utility of murine 14G2a.
Saleh
M N
MN
Division of Hematology/Oncology, University of Alabama, Birmingham 35294-3300.
Khazaeli
M B
MB
Wheeler
R H
RH
Dropcho
E
E
Liu
T
T
Urist
M
M
Miller
D M
DM
Lawson
S
S
Dixon
P
P
Russell
C H
CH
D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D000917:Antibody Formation; D004341:Drug Evaluation; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000378:metabolism / Q000556:secondary / Q000628:therapy*; D010146:Pain / Q000139:chemically induced; D010147:Pain Measurement; D012008:Recurrence; D012074:Remission Induction
D000911:Antibodies, Monoclonal; D005732:Gangliosides; C019403:ganglioside, GD2