Central nervous system binding sites for calcitonin and calcitonin gene-related peptide.
Alternative splicing of the primary RNA transcript of the calcitonin gene leads to the generation of two distinct peptides, calcitonin (CT) and calcitonin gene-related peptide (CGRP). These peptides share only limited sequence homology and generally subserve different biological functions through their own distinct binding sites, which differ in specificity and distribution. Additionally, a binding site with high-affinity binding for both peptides that has a restricted pattern of distribution has been identified. The present article reviews the biochemical and morphological characteristics of centra CT and CGRP binding sites.
Sexton
P M
PM
St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000033:anatomy & histology; D001923:Brain Chemistry; D001931:Brain Mapping; D002116:Calcitonin / Q000235:genetics / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D012326:RNA Splicing; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface / Q000032:analysis*; D013045:Species Specificity; D013116:Spinal Cord / Q000737:chemistry; D014714:Vertebrates / Q000235:genetics
D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide