Reactive oxygen metabolites and colitis: a disturbed balance between damage and protection. A selective review.
Enhanced local production of reactive oxygen metabolites has been found in association with colitis, both experimentally and in humans. Cellular and biochemical systems involved have been identified, and 5-aminosalicylic acid-containing drugs but, more effectively, specific scavengers have been found to reduce the intestinal inflammatory process. The multitude of reactions in which oxygen metabolites participate provides a new area of research in intestinal inflammation. These basic studies might bring related clinical studies in an era of new anti-inflammatory drugs for inflammatory bowel disease specifically designed to scavenge toxic oxygen metabolites.
Verspaget
H W
HW
Dept. of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
Mulder
T P
TP
van der Sluys Veer
A
A
Peña
A S
AS
Lamers
C B
CB
D000818:Animals; D003092:Colitis / Q000378:metabolism* / Q000473:pathology; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D010100:Oxygen