title: Derivatives of 2-mercaptobenzenesulphonamide. IX. Synthesis and some pharmacological properties of N- or S-dialkylaminoalkyl derivatives of 2-(4-chloro-2-mercapto-5-methylbenzenesulphonyl)guanidines.
abstract: Synthesis and results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system of 2-(4-chloro-2-mercapto-5-methylbenzenesulphonyl)guanidine hydrochloride derivatives containing N-dialkylaminoalkyl (V-VI, VIIb-VIIIb, Xa), or S-dialkylaminoalkyl (XI-XIII) groups, were described. Compounds VIIa-VIIIa, IX-X, XIa were isolated as free bases.
authors.affiliation: Department of Drug Technology, School of Medicine, Gdańsk, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Brzozowski
authors.forename: J
authors.initials: J
authors.lastname: Sławiński
authors.forename: M
authors.initials: M
authors.lastname: Kosmala
authors.forename: K
authors.initials: K
authors.lastname: Oledzka
authors.forename: M
authors.initials: M
authors.lastname: Filczewski
authors.forename: J
authors.initials: J
authors.lastname: Miłobedzka
authors.forename: K
authors.initials: K
authors.lastname: Lewandowski
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005260:Female; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D008970:Molecular Weight; D051381:Rats; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D006146:Guanidines; D013438:Sulfhydryl Compounds