[The characteristics of the glucocorticoid receptors in the striatum of hypertensive rats].
In spontaneously hypertensive rats, the hippocampus has two types of glycocorticoid receptors. In stress, an increase of the receptor binding was found, mainly due to the 2 type receptors. Only one type of receptors was found in the striatum. In stress, the maximal binding of H3-corticosterone with the receptors was enhanced and the dissociation constant increased. The change of the receptors in the striatum can underlie the change in regulation of the hypophyseal-adrenal system function by the feedback mechanism occurring in hypertension in the SHR rats.
Garina
I A
IA
Rakitskaia
V V
VV
Shaliapina
V G
VG
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011921:Rats, Inbred WKY; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism; D014316:Tritium
D011965:Receptors, Glucocorticoid; D014316:Tritium; D003345:Corticosterone
Kharakteristika gliukokortikoidnykh retseptorov v striatume u gipertenzivnykh krys.