Phospholipase A2 activity in Epstein-Barr virus-transformed lymphoblast cells from schizophrenic patients.
We examined the activity of phospholipase A2 in Epstein-Barr virus-transformed lymphoblast cell lines established from ten schizophrenic patients and ten controls. A novel method for determination of enzyme activity in whole cells was employed, by measuring the hydrolysis of a fluorescent analogue of phosphatidylcholine. No significant difference in phospholipase A2 activity was found between the groups. These results suggest that the previously reported changes in phospholipase A2 activity in plasma and in fresh peripheral cells are indicative of environmental influences and not of "trait" characteristics intrinsic to schizophrenia.
Bennett
E R
ER
Department of Geriatric Research, Sara Herzog Hospital, Jerusalem, Israel.
Yedgar
S
S
Lerer
B
B
Ebstein
R P
RP
D000328:Adult; D000368:Aged; D002461:Cell Line, Transformed; D005260:Female; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000201:enzymology*; D012565:Schizophrenic Psychology; D012931:Social Environment
D010741:Phospholipases A; D054467:Phospholipases A2