title: Cell cycle kinetics analysis of HeLa cells exposed to aphidicolin: computer simulation.
abstract: A computer simulation model was developed and used to analyze the inhibitory effect of aphidicolin on the proliferation of Hela cells. Simulation results were compared with actual experimental results [Pedrali-Noy et al. (1980) Nuc. Acid Res. 8, 377] and were found to be in good agreement. Also, the simulation showed that aphidicolin caused cells to be accumulated at the G1/S boundary and that recruitment and synchrony occurred.
authors.affiliation: Department of Industrial Engineering, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: S Y
authors.initials: SY
authors.lastname: Abed
authors.forename: S M
authors.initials: SM
authors.lastname: elAssouli
authors.forename: O S
authors.initials: OS
authors.lastname: Ozkul
authors.forename: M
authors.initials: M
authors.lastname: Alidrisi
authors.forename: M
authors.initials: M
authors.lastname: Amer
mesh_terms: D016590:Aphidicolin / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D002478:Cells, Cultured; D003198:Computer Simulation; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008954:Models, Biological; D012984:Software
chemical_list: D016590:Aphidicolin