Intracavitary cisplatin chemotherapy experience with six dogs.
Six dogs with a median age of 7 years (range = 5-14 years) were presented for signs referable to thoracic or abdominal effusion associated with neoplasia of the body cavities. Intracavitary cisplatin was administered at 50 mg/m2 every 4 weeks for a median of 2.5 treatments (mean = 3, range = 1-6). Three dogs with pleural mesothelioma had complete resolution of effusion for 289, 129, and greater than 306 days without evidence of tumor growth. Resolution of effusion occurred after one treatment in two dogs and after two treatments in one dog. In three dogs with carcinomatosis of unknown origin, complete responses was seen in two dogs after one treatment for 255 and greater than 807 days, respectively. Intracavitary chemotherapy with cisplatin was associated with palliation and control of malignant pleural and/or abdominal effusion in five of six dogs. Toxicity was minimal, and this method of therapy should be further explored in dogs with similar malignancies.
Moore
A S
AS
Foster Hospital for Small Animals, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536.
Kirk
C
C
Cardona
A
A
D000230:Adenocarcinoma / Q000188:drug therapy / Q000662:veterinary; D000231:Adenocarcinoma, Papillary / Q000188:drug therapy / Q000662:veterinary; D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy / Q000662:veterinary; D000818:Animals; D001202:Ascitic Fluid / Q000188:drug therapy / Q000662:veterinary*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D007263:Infusions, Parenteral / Q000662:veterinary; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy / Q000662:veterinary; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D016066:Pleural Effusion, Malignant / Q000188:drug therapy / Q000662:veterinary*; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000662:veterinary
D002945:Cisplatin