title: Effects of single and repeated electroconvulsive therapy sessions on plasma ACTH, prolactin, growth hormone and cortisol concentrations.
abstract: To study the effects of electroconvulsive therapy (ECT) on hormone release, we measured circulating concentrations of adrenocorticotropic hormone (ACTH), prolactin (PRL), growth hormone (GH) and cortisol (CORT) immediately before and at 2 min, 5 min, 15 min, and 30 min following ECT. Compared to pre-ECT concentrations, there were significant increases in post-ECT plasma ACTH, PRL and CORT. GH did not change consistently. No significant difference between unilateral and bilateral ECT was observed. Compared to the first ECT, repeated treatments were associated with a significant decrease in the magnitude of hormone surge. These hormonal changes induced by ECT may reflect changes at the neurotransmitter level.
authors.affiliation: Department of Psychiatry, University of Michigan Medical Center, Ann Arbor 48109-0118.
authors.forename: Z
authors.initials: Z
authors.lastname: Kronfol
authors.forename: G
authors.initials: G
authors.lastname: Hamdan-Allen
authors.forename: K
authors.initials: K
authors.lastname: Goel
authors.forename: E M
authors.initials: EM
authors.lastname: Hill
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000628:therapy*; D003866:Depressive Disorder / Q000097:blood* / Q000628:therapy*; D004292:Dominance, Cerebral / Q000502:physiology; D004565:Electroconvulsive Therapy; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D011618:Psychotic Disorders / Q000097:blood* / Q000628:therapy*
chemical_list: D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone