The newly developed neutrophil oxidative burst antagonist apocynin inhibits joint-swelling in rat collagen arthritis.
Methylated catechols like apocynin selectively inhibits neutrophil superoxide production without significant side-effects. When rats were treated orally with low doses of apocynin the severity of collagen-induced arthritis was significantly reduced, pointing at a role of oxyradicals in the induction of this disease.
't Hart
B A
BA
Dept. chronic and infectious diseases, ITRI-TNO, Rijswijk.
Bakker
N P
NP
Labadie
R P
RP
Simons
J M
JM
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D003094:Collagen; D004797:Enzyme-Linked Immunosorbent Assay; D005609:Free Radicals; D007074:Immunoglobulin G / Q000096:biosynthesis; D066298:In Vitro Techniques; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013481:Superoxides / Q000378:metabolism
D000098:Acetophenones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D007074:Immunoglobulin G; D013481:Superoxides; D003094:Collagen; C056165:acetovanillone