Intraseptal administration of bicuculline produces working memory impairments in the rat.
Male Sprague-Dawley rats, trained to perform a delayed-non-match-to-sample eight-arm radial maze task, were implanted with a single cannula aimed at the medial septal nucleus. A within-subjects design was utilized to examine the effects of intraseptal administration of bicuculline (0.5 micrograms) on performance of this task with 1- and 4-h delay intervals imposed between choices four and five. Administration of bicuculline immediately following the first four choices produced an impairment in maze performance at both a 1- and a 4-h delay interval. This treatment also produced an increase in latency per choice. Bicuculline-induced impairments were not observed when administered 2 h following the predelay session (2 h prior to testing). These data support previous observations that pharmacological manipulation of GABAergic activity within the septum modifies working memory processes.
Chrobak
J J
JJ
Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153.
Napier
T C
TC
D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives* / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D009949:Orientation / Q000187:drug effects*; D011334:Proactive Inhibition; D051381:Rats; D011919:Rats, Inbred Strains; D011931:Reactive Inhibition; D011963:Receptors, GABA-A / Q000187:drug effects; D012153:Retention, Psychology / Q000187:drug effects*; D012688:Septum Pellucidum / Q000187:drug effects*
D011963:Receptors, GABA-A; C017069:bicuculline methiodide; D001640:Bicuculline