[Characterization and postnatal evolution of an endogenous protein inhibitor of intestinal fucosyltransferase activities].
An endogenous protein inhibitor was shown to act in vitro on small intestinal fucosyl-transferase activities. In order to support the hypothesis of a physiological role in vivo for this inhibitor in the regulation of the fucosylation process, we characterized this inhibitor and studied its postnatal development. This inhibitor acts differently upon the enzymes of intestinal fucosylation processes. Among the different organs analyzed, the inhibitor was found only in the intestine and the pancreas. Intestinal inhibitory activity decreased 10 fold between the 7th and the 24th day of rat postnatal development; this decrease was inversely correlated with intestinal fucosyl-transferase activities. Two mechanisms of action by which the inhibitor could exert a physiological regulatory role are discussed.
Ruggiero-Lopez
D
D
Laboratoire de Biochimie Générale et Médicale, INSERM U189, Faculté de Médecine Lyon-Sud, Oullins.
Martin
A
A
Louisot
P
P
D000818:Animals; D005647:Fucosyltransferases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006154:Guanosine Diphosphate Fucose / Q000378:metabolism; D006836:Hydro-Lyases / Q000378:metabolism; D007413:Intestinal Mucosa / Q000201:enzymology*; D008297:Male; D011755:Pyrophosphatases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D006154:Guanosine Diphosphate Fucose; D005647:Fucosyltransferases; D011755:Pyrophosphatases; D006836:Hydro-Lyases
Caractérisation et évolution post-natale d'un inhibiteur protéique endogène des fucosyl-transférases intestinales.