[The mechanism of Na+--K+ pump dysfunction in the erythrocytes of patients with glomerulonephritis and kidney failure].
The mechanisms of Na, K-ATPase dysfunction in red blood cells of patients suffering from glomerulonephritis and renal failure were studied by means of "functional loads" of an enzyme, enabling not only the activity but also the routine of Na, K-ATPase to be determined. Evidence is provided for the presence of immunotoxic factor on the patients' red blood cells, in the plasma of venous blood and serum of arterial blood. Its excretion from the patients' body and recovery of the routine of Na, K-ATPase have been simulated in vivo and in vitro. The cold immunoglobulin nature of the inhibitor related to the M-chains of IgM was established. It has been shown that the mechanisms of formation of the immunopathogenesis of glomerulonephritis are associated with the appearance of cold autoantibodies and their fragments on blood cell membranes, bringing about a decrease of the activity of Na, K-ATPase and modifying its routine.
Ponomarenko
E D
ED
Lazovskis
I R
IR
Pletneva
T P
TP
Maslova
M N
MN
D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood* / Q000276:immunology; D001693:Biological Transport, Active; D002908:Chronic Disease; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism*; D005921:Glomerulonephritis / Q000097:blood* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000276:immunology; D007680:Kidney Neoplasms / Q000097:blood / Q000276:immunology; D010195:Pancreatitis / Q000097:blood / Q000276:immunology; D011188:Potassium / Q000097:blood*; D012964:Sodium / Q000097:blood*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D007136:Immunoglobulins; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium
Izuchenie mekhanizma disfunktsii Na+--K+-nasosa v éritrotsitakh bol'nykh s glomerulonefritom i pochechnoĭ nedostatochnost'iu.