Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor.
cDNA clones encoding four new receptors of the G-protein-coupled receptor family were obtained by selective amplification and cloning from thyroid cDNA and termed RDC1, RDC4, RDC7, and RDC8. RDC7 and RDC8 have recently been identified as A1 and A2 adenosine receptors, respectively. These cDNAs were utilized for chromosomal in situ hybridization to establish the genomic location of the corresponding genes in man. The results indicate that human RDC1, RDC4, RDC7, and RDC8 are in regions 2q37, 1p34.3-1p36.3, 22q11.2-22q13.1, and 11q11-11q13, respectively.
Libert
F
F
Institut de recherche Interdisciplinaire, Faculté de Médecine, Université libre de Bruxelles, Belgium.
Passage
E
E
Parmentier
M
M
Simons
M J
MJ
Vassart
G
G
Mattei
M G
MG
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002880:Chromosomes, Human, Pair 11; D002889:Chromosomes, Human, Pair 2; D002892:Chromosomes, Human, Pair 22; D003001:Cloning, Molecular; D006801:Humans; D011964:Receptors, Gastrointestinal Hormone / Q000235:genetics* / Q000378:metabolism; D011983:Receptors, Purinergic / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*; D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D011964:Receptors, Gastrointestinal Hormone; D011983:Receptors, Purinergic; D011985:Receptors, Serotonin; D018005:Receptors, Vasoactive Intestinal Peptide; D014660:Vasoactive Intestinal Peptide