The distribution of T cell subsets of Kveim and sarcoid granulomata. An immunohistological investigation of blood, Kveim test sites and sarcoid tissue lesions from 16 patients.
T lymphocyte subsets in a positive Kveim reaction and sarcoid tissue lesions as well as peripheral blood from 16 patients with sarcoidosis were evaluated with monoclonal antibodies. The data demonstrate a redistribution of T cells from the blood to the specifically involved tissues with granulomas, i.e., sarcoid tissue lesions and positive Kveim reaction. These cells express CD2+, CD4+ phenotype as demonstrated by high CD4/CD8 ratios at the sites of positive Kveim reaction and sarcoid tissue lesions with respect to blood.
Tüzüner
N
N
Department of Pathology, Cerrahpasa Medical School of Istanbul University.
Ulkü
B
B
Uraz
S
S
Güngen
G
G
Demiric
S
S
Celikoglu
S
S
D000328:Adult; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007731:Kveim Test; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000276:immunology* / Q000473:pathology; D016176:T-Lymphocyte Subsets