title: Epstein-Barr virus and malignant lymphoepithelial lesions of the salivary gland.
abstract: This report describes the results of histopathologic and virologic studies in six patients with undifferentiated carcinoma (malignant lymphoepithelial lesions) of the salivary glands. Epstein-Barr virus (EBV) was detected in tumors from all six patients by DNA hybridization, while adjacent non-tumorous salivary gland tissue was negative for EBV in two patients tested for DNA and in three patients tested for Epstein-Barr nuclear antigen (EBNA). These findings add more evidence that these unusual salivary gland tumors are EBV-associated, and that EBV is specific to the tumor.
authors.affiliation: Center for Infectious Diseases, Center for Disease Control, Anchorage, Alaska.
authors.forename: A P
authors.initials: AP
authors.lastname: Lanier
authors.forename: S R
authors.initials: SR
authors.lastname: Clift
authors.forename: G
authors.initials: G
authors.lastname: Bornkamm
authors.forename: W
authors.initials: W
authors.lastname: Henle
authors.forename: H
authors.initials: H
authors.lastname: Goepfert
authors.forename: N
authors.initials: N
authors.lastname: Raab-Traub
mesh_terms: D000293:Adolescent; D000368:Aged; D000956:Antigens, Viral / Q000032:analysis; D002277:Carcinoma / Q000382:microbiology*; D004279:DNA, Viral / Q000032:analysis; D019309:Epstein-Barr Virus Nuclear Antigens; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000382:microbiology*
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens