Serum protein polymorphisms in Arab Moslems and Druze of Israel: BF, F13B, AHSG, GC, PLG, PI, and TF.
We report results of typing two population samples, Israeli Arab Moslems and Arab Druze, for seven serum protein genetic variants. Data are presented in comparison with results for the same markers in a sample of Jordanian Arabs. In Israeli Moslems gene frequencies for BF (n = 169) were BF*S = 0.6361, BF*F = 0.3343, BF*S07 = 0.0296, and BF*1 = 0, and for TF (n = 90) the gene frequencies were: TF*C1 = 0.7167, TF*C2 = 0.2611, and TF*C3 = 0.0222. Allele frequencies for AHSG in Israeli Moslems (n = 155) and Druze (n = 192) were AHSG*1 = 0.9129 and 0.8750 and AHSG*2 = 0.0806 and 0.1250, respectively. Gene frequencies for PLG in Moslems (n = 149) and Druze (n = 190) were PLG*A = 0.4597 and 0.5288 and PLG*B = 0.5101 and 0.4188, respectively. The typing of Israeli Arab Druze (n = 194) for F13B resulted in F13B*1 = 0.8454, F13B*2 = 0.0387, F13B*3 = 0.0979, and F13B*4 = 0.0180. Results on the same population for PI (n = 192) were PI*M1 = 0.7839, PI*M2 = 0.1276, PI*M3 = 0.0781, PI*M4 = 0.0026, and PI*M5 = 0.0026. Observed rare alleles in various systems indicate gene flow from Europe, Africa, and Asia into the Middle East. The results on Arab populations were considered in relation to available population data in the three adjacent continents. The emerging gene frequency profile for Arabs seems to fit with the central geographic and climatic position of the Middle East.
Nevo
S
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Institute of Evolution, University of Haifa, Israel.
Cleve
H
H
Koller
A
A
Eigel
E
E
Patutschnick
W
W
Kanaaneh
H
H
Joel
A
A
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000235:genetics*; D002648:Child; D011415:Complement Factor B / Q000235:genetics; D003241:Consanguinity; D005006:Ethnicity; D005069:Evaluation Studies as Topic; D005176:Factor XIII / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007514:Islam; D007557:Israel; D008297:Male; D010958:Plasminogen / Q000235:genetics; D011110:Polymorphism, Genetic; D012529:Saudi Arabia / Q000208:ethnology; D014168:Transferrin / Q000235:genetics; D014809:Vitamin D-Binding Protein / Q000235:genetics; D000515:alpha 1-Antitrypsin / Q000235:genetics; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D005819:Genetic Markers; D014168:Transferrin; D014809:Vitamin D-Binding Protein; D000515:alpha 1-Antitrypsin; D060749:alpha-2-HS-Glycoprotein; D010958:Plasminogen; D005176:Factor XIII; C054380:factor XIIIb; D011415:Complement Factor B