Anti-staphylococcal activity of temafloxacin, ciprofloxacin, ofloxacin and enoxacin.
Four fluoroquinolones were tested for antimicrobial activity against 300 isolates of staphylococci collected from medical centres throughout the United States. No cross-resistance to methicillin or oxacillin and the fluoroquinolones was observed. All four drugs were bactericidal agents and all ciprofloxacin-susceptible strains were inhibited at recommended breakpoint concentrations. Ciprofloxacin-resistant strains showed complete cross-resistance to the other fluoroquinolones. The relative potency of the study drugs as judged by MIC/MBC determinations was: temafloxacin greater than ciprofloxacin greater than ofloxacin greater than enoxacin.
Barry
A L
AL
Clinical Microbiology Institute Inc., Tualatin, Oregon 97062.
Fuchs
P C
PC
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology; D015365:Enoxacin / Q000494:pharmacology; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D010068:Oxacillin / Q000494:pharmacology; D010403:Penicillin Resistance; D015363:Quinolones / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C054745:temafloxacin; D015365:Enoxacin; D002939:Ciprofloxacin; D015242:Ofloxacin; D010068:Oxacillin