[Regional activity of enkephalin- and angiotensin II-forming peptidases in the rat brain and other peripheral tissues with different craving for ethanol].
Activities of enkephalin- and angiotensin II-forming enzymes (carboxypeptidase H and angiotensin-converting enzyme, ACE) were changed in different brain regions and peripheral tissues of rats with various alcohol motivation. The carboxypeptidase H activity was elevated in midbrain, striatum, hypophysis and adrenal glands, while the ACE activity was increased in hypophysis and striatum. The ACE activity was decreased two-fold in thalamo-hypothalamic region of ethanol-preferring rats.
Gomazkov
O A
OA
Panfilov
A D
AD
Rostovtsev
A P
AP
Komissarova
N V
NV
Fomin
V V
VV
Grigor'iants
O O
OO
D000311:Adrenal Glands / Q000201:enzymology; D000428:Alcohol Drinking / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000201:enzymology*; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010146:Pain / Q000503:physiopathology; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects
D000431:Ethanol; D002268:Carboxypeptidases; D010450:Endopeptidases; D007703:Peptidyl-Dipeptidase A; D043423:Carboxypeptidase H
Regionarnaia aktivnost' énkefalin- i angiotenzin II-obrazuiushchikh peptidaz mozga i perifericheskikh tkaneĭ u krys s razlichnym vlecheniem k étanolu.