Does CMV infection play a role in myocarditis? New aspects from in-situ hybridization.
Endomyocardial biopsies of 20 patients with active myocarditis, 15 with post-myocarditis and 22 with acute perimyocarditis were assayed for cytomegalovirus (CMV) DNA by in-situ hybridization with a biotinylated DNA-probe. Positive probes were found in 10% of the cases with acute myocarditis and in 7% of those with post-myocarditis; no CMV-positive patients were found in acute peri-myocarditis. The results were compared to anti-CMV antibodies from patients sera detected by ELISA technique.
Schönian
U
U
Department of Cardiology, Philipps University of Marburg, Germany.
Crombach
M
M
Maisch
B
B
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000382:microbiology*; D009693:Nucleic Acid Hybridization
D000914:Antibodies, Viral; D015342:DNA Probes; D004279:DNA, Viral