[Proline hydroxylase (hPH) as marker of hepatic fibrosis in beta thalassemia].
Forty-four polytransfused thalassemic patients were considered to evaluate hPH enzyme, involved in collagen synthesis. The aim of this investigation was to verify the usefulness of such assay in the follow-up of liver damage in thalassaemic patients. The patients were separated into two groups: one group with normal transaminase activity and another one with pathological values from more than two years. A group of 20 healty children was chosen for the control values of enzymatic activity. In all patients HCV-Ab was determined. Results obtained confirm the role of viral liver infection in inducing fibrosis in polytransfused thalassaemic patients and suggest the possibility to use hPH assay in their follow-up.
Leonardi
S
S
Clinica Pediatrica dell'Università di Catania, Italia.
Avola
E
E
Rapisarda
R
R
La Delfa
W
W
Musumeci
S
S
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000201:enzymology* / Q000209:etiology; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000097:blood*; D013789:Thalassemia / Q000097:blood / Q000150:complications*
D015415:Biomarkers; D011393:Procollagen-Proline Dioxygenase
La prolinaidrossilasi (hPH) come marker di fibrosi epatica nella beta talassemia.