title: Ki-1+ anaplastic large-cell lymphoma of T-cell origin in an HIV-infected patient.
abstract: Non-Hodgkin's lymphomas (NHL) are part of the spectrum of disease associated with HIV infection. However, there are only occasional reports of NHL of T-cell origin in HIV-infected patients. A previously asymptomatic HIV-infected man, who was seronegative for human T-lymphotropic virus type I antibodies, developed a high-grade peripheral T-cell lymphoma of anaplastic large-cell type which was Ki-1 + (CD30 +), HLA-DR+, epithelial membrane antigen +, CD25 +, CD71 +, CD2 + and CD5 +. Pan-B markers CD19 and CD22 and histiocytic marker CD68 were negative. At diagnosis the patient had 0.3 x 10(9)/l T-helper lymphocytes. The response to chemotherapy was dramatic and the patient is alive and disease-free 18 months after treatment. A review of previously described peripheral T-cell lymphomas in HIV-positive individuals is performed, and we conclude that the spectrum of neoplasms in such cases is probably broader than originally thought.
authors.affiliation: Internal Medicine, University of Barcelona, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: González-Clemente
authors.forename: J M
authors.initials: JM
authors.lastname: Ribera
authors.forename: E
authors.initials: E
authors.lastname: Campo
authors.forename: X
authors.initials: X
authors.lastname: Bosch
authors.forename: E
authors.initials: E
authors.lastname: Montserrat
authors.forename: J M
authors.initials: JM
authors.lastname: Grau
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D016130:Immunophenotyping; D017730:Ki-1 Antigen; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications* / Q000276:immunology; D008297:Male
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen