title: [Incidence of congenital infections].
abstract: The discussions on the pros and cons of obstetric screening for connatal infections have been going on for years. We, therefore, conducted a prevalence study of the most common connatal infections. HIV infection, rubella and syphilis were not subjects of this study. We analysed the relevance of these infections in 512 pregnant women and their newborn infants at the moment of delivery. Further serological tests were run three months post partum, if necessary even for a longer period. Cytomegaly IgG antibodies were found in 46% of the examined women, IgM antibodies in 1.3%. Women under the age of twenty and women of low social standing showed the highest rate of prevalence of infection with CMV. The prevalence of IgG antibodies against parvovirus B 19 was 29%. In 10 mothers, positive IgM titers were found at the time of delivery. In all these women, pregnancies had been uneventful. However, 9 mothers exhibited a significantly raised abortion rate within the last 20 months before delivery. 7 of 512 women turned out to be HBs antigen carriers, 3 women and their babies were anti-HCV positive. The prevalence of toxoplasmosis IgG antibodies was 36%, of IgM antibodies 5.3%. By further investigation (Toxo ISAGA, Toxo IgA) we were able to detect one child with connatal toxoplasmosis. We conclude, that screening for parvovirus B 19 and hepatitis C is required only, if there are contact or clinical hints that the patients might have acquired either one of these infections. But we postulate, that a routine screening programme for hepatitis B and toxoplasmosis should be carried out in all pregnant women.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Frauenklinik am Klinikum Mannheim, Fakultät für Klinische Medizin, Universität Heidelberg.
authors.forename: K
authors.initials: K
authors.lastname: Friese
authors.forename: M
authors.initials: M
authors.lastname: Beichert
authors.forename: H
authors.initials: H
authors.lastname: Hof
authors.forename: W
authors.initials: W
authors.lastname: Weikel
authors.forename: D
authors.initials: D
authors.lastname: Falke
authors.forename: R
authors.initials: R
authors.lastname: Sickinger
authors.forename: F
authors.initials: F
authors.lastname: Melchert
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D016731:Erythema Infectiosum / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D005260:Female; D005858:Germany / Q000453:epidemiology; D006509:Hepatitis B / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D006526:Hepatitis C / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D015997:Neonatal Screening; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control
vernacular_title: Untersuchung zur Häufigkeit konnataler Infektionen.