title: Reactive oxygen metabolites and colitis: a disturbed balance between damage and protection. A selective review.
abstract: Enhanced local production of reactive oxygen metabolites has been found in association with colitis, both experimentally and in humans. Cellular and biochemical systems involved have been identified, and 5-aminosalicylic acid-containing drugs but, more effectively, specific scavengers have been found to reduce the intestinal inflammatory process. The multitude of reactions in which oxygen metabolites participate provides a new area of research in intestinal inflammation. These basic studies might bring related clinical studies in an era of new anti-inflammatory drugs for inflammatory bowel disease specifically designed to scavenge toxic oxygen metabolites.
authors.affiliation: Dept. of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.
authors.forename: H W
authors.initials: HW
authors.lastname: Verspaget
authors.forename: T P
authors.initials: TP
authors.lastname: Mulder
authors.forename: A
authors.initials: A
authors.lastname: van der Sluys Veer
authors.forename: A S
authors.initials: AS
authors.lastname: Peña
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
mesh_terms: D000818:Animals; D003092:Colitis / Q000378:metabolism* / Q000473:pathology; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical; D006997:Hypochlorous Acid; D006861:Hydrogen Peroxide; D013482:Superoxide Dismutase; D010100:Oxygen