Expression of a truncated protein-tyrosine phosphatase mRNA in human lung.
Protein-tyrosine phosphatases (PTPases) are becoming an important family of enzymes that might regulate key events in cell growth and transformation. While isolating a new member of this family via amplification of human lung cDNA by the polymerase chain reaction, we found a clone identical to but truncated at the 3'-end of the coding region of human PTPase beta (HPTP beta) mRNA. This difference in sequence is situated in the most conserved part of the catalytic domain of the enzyme. The expression level of the truncated form of HPTP beta mRNA in human lung was lower than its normal form.
De Vries
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INSERM Unité 326, Hôpital Purpan, Toulouse, France.
Li
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RY
Ragab
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Ragab-Thomas
J M
JM
Chap
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D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D008168:Lung / Q000201:enzymology*; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000737:chemistry; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D017027:Protein Tyrosine Phosphatases
D009841:Oligonucleotides; D004247:DNA; D010749:Phosphoprotein Phosphatases; D017027:Protein Tyrosine Phosphatases