Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines.
The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site.
Anzini
M
M
Dipartimento Farmaco Chimico Tecnologico-Università, Siena, Italy.
Cappelli
A
A
Vomero
S
S
Campiani
G
G
Cagnotto
A
A
Skorupska
M
M
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D017374:Paroxetine; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D010880:Piperidines / Q000378:metabolism; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology; D011814:Quipazine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists
D008024:Ligands; D010879:Piperazines; D010880:Piperidines; D015363:Quinolones; D012702:Serotonin Antagonists; D012701:Serotonin; D017374:Paroxetine; D011814:Quipazine