Antigenic variation of pseudorabies virus glycoproteins g II and g III demonstrated by neutralizing monoclonal antibodies.
Antigenic variation of pseudorabies virus glycoprotein g II was demonstrated in field isolates by neutralizing monoclonal antibodies. Mutants capable of avoiding neutralization by the monoclonal antibodies specific for glycoproteins g II and g III could be obtained from the parent virus by mutagenesis.
Yamada
S
S
Second Research Division, National Institute of Animal Health, Ibaraki, Japan.
Imada
T
T
Nishimori
T
T
Sekikawa
K
K
Shimizu
M
M
D000818:Animals; D000911:Antibodies, Monoclonal; D000940:Antigenic Variation; D005455:Fluorescent Antibody Technique; D011558:Herpesvirus 1, Suid / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D016296:Mutagenesis; D009500:Neutralization Tests; D014759:Viral Envelope Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D014759:Viral Envelope Proteins; C042966:pseudorabies virus glycoproteins