title: Endogenous digoxin-like immunoreactivity in follicular fluid and in vitro fertilization.
abstract: Plasma digoxin-like immunoreactive factor (DLIF) has been detected in various pathophysiological conditions associated with volume expansion. In this study, using radioimmunoassay, we confirmed the existence of high levels of DLIF in the stimulated follicular fluid, a rapidly volume-expanding biological model. The concentration of the various fractions of DLIF in follicular fluid was 2-9 times higher than in plasma, suggesting local concentration or production. No difference in concentration was observed between follicles containing fertilized oocytes and follicles with unfertilized oocytes. The role of DLIF in follicular homeostasis remains to be further investigated.
authors.affiliation: Department of Obstetrics/Gynecology B, Rambam Medical Center, Haifa, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Jakobi
authors.forename: N
authors.initials: N
authors.lastname: Krivoy
authors.forename: I
authors.initials: I
authors.lastname: Eibschitz
authors.forename: G
authors.initials: G
authors.lastname: Ziskind
mesh_terms: D001798:Blood Proteins / Q000032:analysis*; D002298:Cardenolides; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004077:Digoxin; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction; D011863:Radioimmunoassay; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
chemical_list: D001798:Blood Proteins; D002298:Cardenolides; D006063:Chorionic Gonadotropin; D012503:Saponins; C034504:digoxin-like factors; D008596:Menotropins; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase