Prostate plasma membrane receptor: a hypothesis.
Based on 50 years of emerging knowledge about and changing views of prostate biochemistry and physiology and especially on the belief that there is an underlying mechanism of androgen control, the hypothesis is developed and tested that the rates of proliferation, biosynthesis, metabolism, and secretion are modulated through the hormone-sensitive Na, K-ATPase of the plasma membrane. These preliminary experiments, constituting a novel synthesis of technologies from endocrinology, intermediary metabolism, and membrane transport, attempt to explain the extraordinary production and secretion of citrate and how this may be coupled to sustaining prostate cell number and function. Attention is focused on learning where androgen is bound and how it interacts with the Na,K-ATPase. Both the dissimilar properties of epithelial and stromal cells in the separate regions of the acinus and the changing environment of growth factors in which these cells are bathed help account for their unlike reactivities during development and ongoing mature function. Little wonder that one hormone can have so many effects!
Farnsworth
W E
WE
Department of Biochemistry, Chicago College of Osteopathic Medicine, Downers Grove.
D000728:Androgens / Q000502:physiology; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D008297:Male; D011467:Prostate / Q000201:enzymology* / Q000502:physiology / Q000648:ultrastructure; D011944:Receptors, Androgen / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism / Q000502:physiology*
D000728:Androgens; D011944:Receptors, Androgen; D000254:Sodium-Potassium-Exchanging ATPase