[Concentration profile of PCBs in the digestive tract of rat fed with cholestyramine and rice bran fiber diet].
The aim of this study is to examine the inhibitory effect of rice bran fiber (RBF) and cholestyramine for intestinal absorption of polychlorinated biphenyls (PCBs). Sixteen rats were orally given at the dose of 100 mg of PCBs per kg of the animal, and were divided into four groups (A-D): Rats in each group were housed with the normal diet for the first 7 days, and subsequently, were given with the same diet as control for group A, with the diet containing 10% RBF for group B, with the diet containing 5% cholestyramine for group C and with the combined diet containing 10% RBF and 5% cholestyramine for group D for the next 10 days. All rats were sacrificed on the 17th day after PCBs administration, and PCBs in contents of the digestive tracts were determined: small and large intestine resected was divided into two parts each of the same length, and the contents were chemically analyzed to determine PCBs. PCBs concentration in rats of group A decreased in order of upper portions (1.0 microgram/g) and then lower (0.6 microgram/g) of small intestine, and upper (0.5 microgram/g) and then lower (0.4 microgram/g) of large intestine. Decreasing the PCBs concentration might be due to re-absorption in the intestine. In the case of groups B-D, PCBs concentration was in order of upper and then lower of small intestine, and large intestine. It was indicated that PCBs re-absorption in intestine is inhibited by the intake of RBF, cholestyramine, and RBF and cholestyramine.
Narazaki
Y
Y
Department of Health Science, Fukuoka Environmental Research Center.
Morita
K
K
Fukamachi
K
K
Tokiwa
H
H
Takahashi
K
K
D000818:Animals; D002792:Cholestyramine Resin / Q000008:administration & dosage*; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage*; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains
D004043:Dietary Fiber; D002792:Cholestyramine Resin; D011078:Polychlorinated Biphenyls