Antiviral agents: synthesis of furylpyrimidinones and evaluation of their cytostatic and antiviral activity.
Condensation between furyllithium reagents and pyrimidinones 1, 2, 3, and 4 has been studied. The product composition is strongly dependent upon the reaction conditions and purification methodologies. Cytostatic and antiviral activities of some substrates and reaction products is reported.
Botta
M
M
Dipartimento Farmaco Chimico Tecnologico, Università di Siena.
De Angelis
F
F
Corelli
F
F
Menichincheri
M
M
Nicoletti
R
R
Marongiu
M E
ME
Pani
A
A
La Colla
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D051379:Mice; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D018139:Simplexvirus / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014709:Vero Cells
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D005663:Furans; D011744:Pyrimidinones