[Effect of berberine, glaucine, stephaglabrine and sanguiritrine on neuromuscular transmission].
Natural alkaloid drugs, glaucine, stephaglabrine and sanguiritrine, are shown to affect the synaptic transmission in a fairly complicated manner and seem to involve several different mechanisms of action. These substances as well as berberine reduce amplitude of the spontaneous miniature end plate potentials in a frog neuromuscular junction. At low concentrations all the mentioned alkaloids diminish frequency of miniature potentials, but increase it when their concentration exceeds a certain value. Sanguiritrine is the most active in this respect (nearly a 100-fold increase), that is probably associated with its uncoupling effect on the mitochondrial oxidative phosphorylation. Sanguiritrine and stephaglabrine both cause repeated muscle contractions, that is in line with their anti-cholinesterase properties. Glaucine provokes only muscle contracture if present at relatively high concentration.
Bitkov
V V
VV
Khashaev
Kh -M
Kh-
Pronevich
L A
LA
Nenashev
V A
VA
Batrakov
S G
SG
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001060:Aporphines / Q000494:pharmacology; D001599:Berberine / Q000494:pharmacology; D066298:In Vitro Techniques; D007546:Isoquinolines; D008930:Mitochondria, Liver / Q000187:drug effects; D009045:Motor Endplate / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011896:Rana temporaria; D051381:Rats; D011919:Rats, Inbred Strains; D009435:Synaptic Transmission / Q000187:drug effects*
D000470:Alkaloids; D001060:Aporphines; D007546:Isoquinolines; D001599:Berberine; C070443:stephaglabrine; C070444:sanguiritrine; C005004:glaucine
Deĭstvie berberina, glautina, stefaglabrina i sangviritrina na nervno-myshechnuiu peredachu.