title: Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.
abstract: 2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.
authors.affiliation: Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, Alabama 35255-5305.
authors.forename: J A
authors.initials: JA
authors.lastname: Secrist
authors.forename: K N
authors.initials: KN
authors.lastname: Tiwari
authors.forename: J M
authors.initials: JM
authors.lastname: Riordan
authors.forename: J A
authors.initials: JA
authors.lastname: Montgomery
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D003587:Cytomegalovirus / Q000187:drug effects; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D015458:Leukemia, T-Cell / Q000188:drug therapy; D051379:Mice; D018139:Simplexvirus / Q000187:drug effects; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000627:therapeutic use; D013891:Thiouridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D013872:Thionucleosides; D003841:Deoxycytidine; C070453:2'-deoxy-4'-thiocytidine; C070455:2'-deoxy-4'-thiouridine; C070456:4'-thiothymidine; D013891:Thiouridine; D013936:Thymidine; D003857:Deoxyuridine