[A new class of cardiotonic steroids].
A series of 23-oxosteroid derivatives have been synthesized and tested for their inhibiting Na+, K(+)-dependent ATPase from rat brain in the 1 x 10(-6)-1 x 10(-4) M concentrations. Natural 23-oxogenins from sea star Asterias amurensis and synthetic monoesters showed the inhibiting activity upto 50-55%. These compounds caused heart contraction in frogs at the level of the known cardiotonic strophanthin G, and inotropic activity on isolated heart of mollusk Spisula sachalinensis.
Kamernitskiĭ
A V
AV
Kutnevich
I A
IA
Reshetova
I G
IG
Chernoburova
E I
EI
Gorshkov
B A
BA
Gorshkova
I A
IA
Kapustina
I I
II
D000818:Animals; D001001:Anura; D001921:Brain / Q000187:drug effects; D002301:Cardiac Glycosides / Q000138:chemical synthesis / Q000494:pharmacology*; D066298:In Vitro Techniques; D008974:Mollusca; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D012615:Sea Anemones; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D002301:Cardiac Glycosides; D000254:Sodium-Potassium-Exchanging ATPase
Novyĭ klass kardiotonicheskikh steroidov.