[The possible role of presynaptic effects in realizing the protective action of M-cholinolytics in dimethyl dichlorovinyl phosphate poisoning].
Under the conditions of the constancy of the postsynaptic effect of two M-cholinolytics atropine and amizil the relationship between the presynaptic and protective effects of the drugs in DDVF intoxication was studied. The indication of the level of the postsynaptic activity was the suppression by the cholinolytics of tremor reaction in rats induced by the action of arecoline. The presynaptic effect of the drugs was judged by the charge of the "bound" acetylcholine content in the brains of the animals. It was found that when administered in the equieffective by the choline-blocking activity doses, atropine to a greater extent reduced the content of the "bound" acetylcholine which was increased due to the action of DDVF and at the same time it possessed the less pronounced protective activity in intoxication with DDVF than amizil. It is supposed that the removal of the presynaptic suppression of acetylcholine release due to the anticholinesterase substance action deteriorates the prognosis of the course of DDVF intoxication.
Kosmachev
A B
AB
Filippov
V N
VN
Kosmacheva
I M
IM
Khobotova
Z I
ZI
Kuleshov
V I
VI
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001115:Arecoline; D001286:Atropine Derivatives / Q000627:therapeutic use / Q000633:toxicity; D001535:Benactyzine / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004006:Dichlorvos / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007928:Lethal Dose 50; D010276:Parasympatholytics / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy
D001286:Atropine Derivatives; D010276:Parasympatholytics; D017981:Receptors, Neurotransmitter; D001115:Arecoline; D001535:Benactyzine; D004006:Dichlorvos; C006649:methylatropine; D000109:Acetylcholine
Vozmozhnaia rol' presinapticheskikh éffektov v osushchestvlenii zashchitnogo deĭstviia M-kholinolitikov pri otravlenii dimetildikhlorvinilfosfatom.