title: [Perinatal infection due to cytomegaloviruses in a public hospital of the municipality of São Paulo: a prospective study].
abstract: In order to demonstrate the occurrence of CMV perinatal infection in a middle socioeconomic class population, the authors conducted a 8-month prospective study in 37 children, not infected congenitally, born in a public hospital of São Paulo city, Prevalence of CMV-IgG antibodies in mothers, detected by immunoenzymatic assay (ELISA), was 92.7%. Survival analysis showed that the risk of acquiring CMV perinatal infection diagnosed by virus isolation in human fibroblasts was 30.9%. When the diagnostic method was detection of IgM class antibodies by indirect immunofluorescence the risk was 8.1% (p < 0.05). Milk samples inoculated in human fibroblasts failed to demonstrate the presence of virus. The infected children did not present any signal of disease in a 4-month follow-up.
authors.affiliation: Departamento de Doenças Infecciosas e Parasitárias, Escola Paulista de Medicina São Paulo, Brasil.
authors.forename: C M
authors.initials: CM
authors.lastname: Machado
authors.forename: M C
authors.initials: MC
authors.lastname: Fink
authors.forename: L S
authors.initials: LS
authors.lastname: Boas
authors.forename: L M
authors.initials: LM
authors.lastname: Sumita
authors.forename: A
authors.initials: A
authors.lastname: Weinberg
authors.forename: K
authors.initials: K
authors.lastname: Shiguematsu
authors.forename: I C
authors.initials: IC
authors.lastname: Souza
authors.forename: L D
authors.initials: LD
authors.lastname: Casanova
authors.forename: C S
authors.initials: CS
authors.lastname: Pannuti
mesh_terms: D001938:Brazil / Q000453:epidemiology; D002584:Cervix Uteri / Q000382:microbiology; D003428:Cross Infection / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008895:Milk, Human / Q000382:microbiology; D011247:Pregnancy; D011446:Prospective Studies; D012959:Socioeconomic Factors
vernacular_title: Infecção perinatal pelo citomegalovírus em hospital público do município de São Paulo: estudo prospectivo.