title: Tumours of mesothelial origin in rats following inoculation with biogenic silica fibres.
abstract: Pleural implant experiments using Sprague-Dawley rats have shown that those injected with the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenenthren-17-one (11-methyl-17-ketone) intraperitoneally followed by silica fibres intrapleurally develop mesotheliomas. These tumours were histologically similar to those induced by crocidolite alone. The intraperitoneal injection of 11-methyl-17-ketone also induced leukaemia.
authors.affiliation: Joint Academic Unit of Obstetrics, Gynaecology and Reproductive Physiology, Royal London Hospital, Whitechapel, UK.
authors.forename: T S
authors.initials: TS
authors.lastname: Bhatt
authors.forename: S
authors.initials: S
authors.lastname: Lang
authors.forename: M N
authors.initials: MN
authors.lastname: Sheppard
mesh_terms: D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D006067:Gonanes / Q000633:toxicity; D007267:Injections; D007274:Injections, Intraperitoneal; D007951:Leukemia, Myeloid / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced*; D010212:Papilloma / Q000139:chemically induced; D010994:Pleura; D051381:Rats; D011919:Rats, Inbred Strains; D012822:Silicon Dioxide / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D006067:Gonanes; D012822:Silicon Dioxide; C005765:15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one