title: [Excitatory beta-adrenoreceptors on enteral cholinergic interneurons of the large intestine and ileocecal sphincter].
abstract: Acute experiments were performed on the isolated intestinal loop, vascularly perfused with arterial blood by means of the constant flow perfusion pump. Contractile activity of the ileocecal sphincter and proximal parts of the large intestine was estimated by the maximal isometric tension and total (integrated) contractile activity. Isoprenaline (1-2 mg) induced contractile responses of the colonic segment and ileocecal sphincter. These responses were abolished or dramatically diminished by the blockade of beta-adrenoceptors, muscarinic, and nicotinic cholinergic receptors. Data obtained support the idea, that the large intestine and ileocecal sphincter have excitatory beta-adrenoceptors localized on cholinergic interneurones of the enteric nervous system.
authors.forename: V I
authors.initials: VI
authors.lastname: Ovsiannikov
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Grishina
mesh_terms: D000818:Animals; D002415:Cats; D002799:Cholinergic Fibers / Q000737:chemistry*; D006801:Humans; D007080:Ileocecal Valve / Q000294:innervation* / Q000502:physiology; D066298:In Vitro Techniques; D007395:Interneurons / Q000737:chemistry*; D007421:Intestine, Small / Q000294:innervation* / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000032:analysis / Q000187:drug effects / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology
chemical_list: D011943:Receptors, Adrenergic, beta; D011950:Receptors, Cholinergic
vernacular_title: Vozbuzhdaiushchie beta-adrenoretseptory na énteral'nykh kholinérgicheskikh interneĭronakh tolstoĭ kishki i ileotsekal'nogo sfinktera.