The influence of adrenoreactive preparations on clinical and haemodynamic parameters in patients with ischaemic heart disease.
The influence of anaprilin, oxprenolol, nonachlazine, prazosin and levodopa on the clinical course and haemodynamics was investigated in 138 patients with ischaemic heart disease in whom selective coronary angiography had revealed an up to 50 percent stenosis of one of coronary arteries. The clinical picture of IHD patients with a high tolerance of physical exercise was characterized by a preponderance of spontaneous angina pectoris accompanied by painless myocardial ischaemia. A certain role in the genesis of these disturbances is played by the relative increase in the activity of alpha 1-adrenoreceptors and decrease in beta-adrenoreceptor activity. Prazosin and nonachlazine in monotherapy reduced the number of anginal attacks and episodes of painless myocardial ischaemia.
Piatak
O A
OA
Chair of Therapy, Paediatric Faculty, Kiev Medical Institute, USSR.
Yanovskii
G V
GV
Lizogub
V G
VG
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology; D003324:Coronary Artery Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D003327:Coronary Disease / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D004311:Double-Blind Method; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009628:Nonachlazine / Q000494:pharmacology / Q000627:therapeutic use*; D010096:Oxprenolol / Q000494:pharmacology / Q000627:therapeutic use*; D011224:Prazosin / Q000494:pharmacology / Q000627:therapeutic use*; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D007980:Levodopa; D010096:Oxprenolol; D009628:Nonachlazine; D011433:Propranolol; D011224:Prazosin