Hepatocellular carcinoma in a long-term survivor of intrahepatic biliary duct hypoplasia.
We describe the development of hepatocellular carcinoma (HCC) in a 46-yr-old woman with intrahepatic biliary duct hypoplasia. Her underlying liver disease was quiescent for many years until a dramatic rise in serum bilirubin was seen. Orthotopic liver transplantation was performed, and a large tumor was found during surgery. A bile-producing HCC was identified, infiltrating about 50% of an otherwise noncirrhotic liver which had a paucity of intrahepatic ducts. The findings of HCC in this long-term survivor of intrahepatic biliary duct hypoplasia indicates HCC may occur in patients with long-standing disease.
Bach
N
N
Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, City University of New York.
Kahn
H
H
Thung
S N
SN
Schaffner
F
F
Klion
F M
FM
Miller
C M
CM
D001653:Bile Ducts, Intrahepatic / Q000002:abnormalities*; D001663:Bilirubin / Q000097:blood*; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000601:surgery; D000013:Congenital Abnormalities / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology* / Q000601:surgery; D016031:Liver Transplantation; D008875:Middle Aged
D001663:Bilirubin