title: [Interleukin-1 and other proinflammatory cytokines].
abstract: Interleukin 1 (IL 1), tumor necrosis factor or alpha and Interleukin 6 are members of a family of soluble factors or cytokines which have multiple biologic activities and play a major role in host defence and in the pathogenesis of various diseases. They act at a low concentration on specific receptors. Their role includes host defence with fever, inflammatory cell migration, activation of immune cells, destruction of bone and cartilage. IL 1 activities are included in a cytokine network which amplifies and regulates the effects of numerous cytokines. Current research is aimed at obtaining drugs capable of modulating the effects of these cytokines.
authors.affiliation: Laboratoire d'immunologie, INSERM U80, hôpital E Herriot, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Miossec
mesh_terms: D016207:Cytokines / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D007375:Interleukin-1 / Q000276:immunology / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha
vernacular_title: L'interleukine 1 et autres cytokines proinflammatoires.