title: A negative correlation between the induction of long-term potentiation and activation of immediate early genes.
abstract: In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos and zif/268) using several different high-frequency stimulation paradigms. Stimulation parameters that effectively induced LTP were not associated with IEG activation. Conversely, stimulation parameters that failed to induce LTP consistently resulted in IEG activation. These results suggest that there is a negative correlation between IEG activation and LTP, and that activation of IEGs is neither necessary nor sufficient for the induction of LTP.
authors.affiliation: Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.
authors.forename: S S
authors.initials: SS
authors.lastname: Schreiber
authors.forename: S
authors.initials: S
authors.lastname: Maren
authors.forename: G
authors.initials: G
authors.lastname: Tocco
authors.forename: T J
authors.initials: TJ
authors.lastname: Shors
authors.forename: R F
authors.initials: RF
authors.lastname: Thompson
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D005786:Gene Expression Regulation / Q000502:physiology*; D016762:Genes, fos / Q000235:genetics; D006624:Hippocampus / Q000502:physiology*; D051381:Rats; D013569:Synapses / Q000502:physiology*; D013997:Time Factors