title: Metastasizing eccrine porocarcinoma. Report of two cases with fatal outcome.
abstract: The clinical, histopathological and ultrastructural features of a metastasizing eccrine porocarcinoma are described in a 75-year-old woman and a 82-year-old woman. The previously not recognized tumors were identified by its distinct pattern of metastasis. Metastatic spreading was restricted for years to a circumscribed region of the skin. Histology and electron microscopy disclosed pronounced epidermotropism of the PAS-positive tumor cells. The characteristic pattern of dissemination obviously represents a homing phenomenon of the tumor cells derived from the intraepidermal sweat gland duct.
authors.affiliation: Department of Dermatology, University of Münster, FRG.
authors.forename: G
authors.initials: G
authors.lastname: Kolde
authors.forename: E
authors.initials: E
authors.lastname: Macher
authors.forename: E
authors.initials: E
authors.lastname: Grundmann
mesh_terms: D006607:Adenoma, Sweat Gland / Q000556:secondary* / Q000648:ultrastructure; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006652:Histological Techniques; D006801:Humans; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*; D013544:Sweat Gland Neoplasms / Q000473:pathology*