Effects of corticosterone and microgravity on inflammatory cell production of superoxide.
In this investigation we studied the effects of corticosterone and microgravity on Propionibacterium acnes-induced inflammatory cells ability to produce superoxide (O2-). We found in vitro and in vivo exposure of murine peritoneal inflammatory cells to corticosterone did not inhibit the O2- response. We also found that in microgravity P. acnes-induced inflammatory cells were capable of producing four times as much O2- as at 1g. Therefore, neither corticosterone nor microgravity experienced during parabolic flight prevents an O2- response by inflammatory cells.
Fleming
S D
SD
Division of Biology, Kansas State University, Manhattan 66506.
Edelman
L S
LS
Chapes
S K
SK
D000818:Animals; D003345:Corticosterone / Q000494:pharmacology*; D005260:Female; D006112:Gravitation; D007249:Inflammation / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009504:Neutrophils / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
D013481:Superoxides; D003345:Corticosterone