[The effect of proton therapy on the protein-amino acid metabolism in Itsenko-Cushing disease].
The composition and blood concentration of free aminoacids and other aminocompounds were investigated using automatic aminoacid analysis by a physiological program in 12 patients with diagnosed corticotropin secreting hypophyseal disease (Itsenko-Cushing disease) before and 1-3 years after proton "hypophysectomy". Imbalance of components of the glucose-alanine cycle, expressed in hypoalaninemia and raised concentration of aminoacids with a bifurcated lateral chain, was detected against a background of marked hypercorticotropinemia and hypercorticolism. Single irradiation of the pituitary gland with a proton beam at absorbed doses of 100-120 Gy in the maximum of a deep field resulted in remission and normalization of aminograms of blood plasma (suggesting pathogenicity of proton-beam therapy) for 6-12 mos. The authors discussed probable mechanisms of the interrelationship of protein-amino-acid and carbohydrate metabolic derangements and their correlation with a type of changes in the hormonal balance.
Konnov
B A
BA
Konnova
L A
LA
Lebedeva
N A
NA
Shalek
R A
RA
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D003480:Cushing Syndrome / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010315:Particle Accelerators; D011522:Protons; D011882:Radiotherapy, High-Energy
D000596:Amino Acids; D001798:Blood Proteins; D011522:Protons
Vliianie protonnoĭ terapii na belkovo-aminokislotnyĭ metabolizm pri bolezni Itsenko-Kushinga.