[Indicators of osmotic homeostasis and blood rheology in the acute period of cerebrovascular disorders].
Examination of 80 patients with ischemic and hemorrhagic brain strokes has revealed definite phasic alterations that occur in osmotic homeostasis and hemorheology. In the acute disease period, the intensity of the hyperosmolar syndrome is dependent on the levels of hyperglycemia, azotemia, hypernatremia and is provoked by the impairment of the central and peripheral mechanisms of regulation of water-electrolyte metabolism and osmotic homeostasis as a result of the direct effect of the pathological focus or secondary impairment of the brain stem due to brain edema associated with dislocation of the median and stem structures. That the disease exhibits in the presence of progressively increasing hyperosmia, the decreased parameters of hemolysis coupled with a gradual decline of the aggregation capacity of platelets and red blood cells, blood viscosity, with the high fibrinogen indicators being preserved, points to the failure of the functional potentialities of blood cell elements. The data obtained can serve as a prognostic criterion for the disease outcome and efficacy of infusion and dehydration therapy.
Chukanova
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EI
Iasamanova
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AN
D000208:Acute Disease; D001809:Blood Viscosity / Q000502:physiology*; D001929:Brain Edema / Q000209:etiology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000378:metabolism*; D006801:Humans; D009994:Osmolar Concentration; D009995:Osmosis; D014882:Water-Electrolyte Balance / Q000502:physiology*
Pokazateli osmoticheskogo gomeostaza i gemoreologii v ostrom periode mozgovogo krovoobrashcheniia.