title: Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins.
abstract: Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.
authors.affiliation: School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kusano
authors.forename: T
authors.initials: T
authors.lastname: Nikaido
authors.forename: T
authors.initials: T
authors.lastname: Kuge
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
authors.forename: G
authors.initials: G
authors.lastname: Delle Monache
authors.forename: B
authors.initials: B
authors.lastname: Botta
authors.forename: M
authors.initials: M
authors.lastname: Botta
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D003374:Coumarins / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006035:Glycyrrhiza; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
chemical_list: D003374:Coumarins; D005419:Flavonoids; D015105:3',5'-Cyclic-AMP Phosphodiesterases