title: Oxygen free radicals and pelvic adhesion formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model.
abstract: Intraperitoneal superoxide dismutase (SOD) and catalase were used to block the toxic effects of superoxide anion (O2) and hydrogen peroxide (H2O2), associated with the production of endometriosis and inflammation in a rabbit model. In a two-part animal study, the combined instillation of SOD and catalase significantly reduced the formation of intraperitoneal adhesions at endometriosis sites.
authors.affiliation: University of Michigan Medical Center, Department of Obstetrics and Gynecology, Ann Arbor.
authors.forename: D M
authors.initials: DM
authors.lastname: Portz
authors.forename: T E
authors.initials: TE
authors.lastname: Elkins
authors.forename: R
authors.initials: R
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Warren
authors.forename: S
authors.initials: S
authors.lastname: Adadevoh
authors.forename: J
authors.initials: J
authors.lastname: Randolph
mesh_terms: D000818:Animals; D002374:Catalase / Q000008:administration & dosage*; D004715:Endometriosis / Q000150:complications / Q000378:metabolism; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010386:Pelvic Neoplasms / Q000150:complications / Q000378:metabolism; D010532:Peritoneal Diseases / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D011817:Rabbits; D013482:Superoxide Dismutase / Q000008:administration & dosage*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
chemical_list: D005609:Free Radicals; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D010100:Oxygen