title: Reverse gyrase in thermophilic eubacteria.
abstract: The presence of reverse gyrase, an unusual ATP-dependent type I topoisomerase first isolated from thermophilic archaebacteria, has been detected in four strains of Thermotogales, an order of extremely thermophilic eubacteria. This result suggests that reverse gyrase plays a key role in high-temperature-living organisms, independently of the evolutionary kingdom to which they belong.
authors.affiliation: Laboratoire d'Enzymologie des Acides Nucléiques, URA 554 Centre National de la recherche Scientifique, Université Pierre et Marie Curie, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Bouthier de la Tour
authors.forename: C
authors.initials: C
authors.lastname: Portemer
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: P
authors.initials: P
authors.lastname: Forterre
authors.forename: M
authors.initials: M
authors.lastname: Duguet
mesh_terms: D001105:Archaea / Q000201:enzymology*; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II / Q000737:chemistry / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000737:chemistry; D004278:DNA, Superhelical / Q000737:chemistry; D013696:Temperature
chemical_list: D004269:DNA, Bacterial; D004278:DNA, Superhelical; C041813:DNA reverse gyrase; D004264:DNA Topoisomerases, Type I; D004250:DNA Topoisomerases, Type II