Effect of ethanol and DSIP on the 36Cl-flux in synaptosomal vesicles.
Delta-sleep-inducing peptide (DSIP) is an endogenous substance that regulates the response of the organism to stress. It was found that DSIP, like diazepam and ethanol, activates muscimol-stimulated 36Cl- uptake in the rat brain cortex and partially counteracts the stimulatory action of ethanol on this process. The effect of peptide disappears at the lowering of the incubation temperature. We propose that DSIP is a concordant regulator partly mediating its action through the membrane phospholipids.
Yukhananov
R
R
Institute of Pharmacology, Academy of Medical Sciences, Moscow, USSR.
Rebrov
I
I
Tennila
T
T
Maisky
A
A
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D003975:Diazepam / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D008563:Membrane Lipids / Q000378:metabolism; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D013696:Temperature
D002712:Chlorides; D008563:Membrane Lipids; D011963:Receptors, GABA-A; D009118:Muscimol; D000431:Ethanol; D003701:Delta Sleep-Inducing Peptide; D003975:Diazepam