[Evaluation of the effect of d,l-carnitine on lipid metabolism of patients after prolonged dialysis].
An effect of carnitine (Bicarnesine) on lipid metabolism in 14 patients treated with prolonged dialyses has been analysed. Carnitine has been administered orally in the dose of 30 mg/kg b.w. three times per week for 8 weeks and every day for the next 8 weeks. Carnitine, total triglycerides, total and HDL cholesterol, and glucose have been determined in serum. Blood lipoproteins have been assayed with electrophoresis in agarose gel. Total and free carnitine concentrations increased by 3.5 times within 16 weeks. Triglycerides level did not change significantly in all examined patients except a group of 6 patients with baseline hypertriglyceridemia, in which a significant but transient decrease in triglycerides level has been noted after 4 weeks of treatment. At the same time, normalization of blood lipoproteins has been observed. In the eighth week, a transient decrease in HDL-cholesterol has been noted. Result suggest, that carnitine despite an increase in total and free carnitine blood levels did not regulate lipid metabolism disorders. Moreover, its administration to patients treated with prolonged dialyses seems to be unfavourable due to several adverse reactions.
Król
E
E
Kliniki Chorób Nerek, Gdańsku.
Rutkowski
B
B
Manitius
J
J
Manitius
A
A
Sałek
J
J
Wróblewska
M
M
Lysiak-Szydłowska
W
W
D000328:Adult; D002331:Carnitine / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D008055:Lipids; D002331:Carnitine
Ocena wpływu preparatu D,L-karnityny na gospodarke lipidowa u chorych przewlekle dializowanych.