Autoradiographic evidence of 125I-beta-endorphin binding sites in the articular cartilage of the rat.
After 125I-beta-endorphin was intravenously injected to rats, an autoradiographic study of distal femur articular cartilage was performed. Results show a specific binding of 125I-beta-endorphin to chondrocytes, suggesting the possible existence of an opiate modulation of articular cartilage.
Castaño
M T
MT
Department of Anatomy, School of Medicine, University of Santiago, Spain.
Freire-Garabal
M
M
Giraldez
M
M
Núñez
M J
MJ
Belmonte
A
A
Couceiro
J
J
Jorge
J
J
D000818:Animals; D001345:Autoradiography; D002358:Cartilage, Articular / Q000378:metabolism*; D006614:Hindlimb; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism*; D001615:beta-Endorphin / Q000378:metabolism*
D011957:Receptors, Opioid; D009270:Naloxone; D001615:beta-Endorphin; D009020:Morphine