title: Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
abstract: A female patient in whom acute nonlymphocytic leukemia (ANLL, FAB-M6) developed during treatment of hepatocellular carcinoma (HCC) is described. Two years after partial hepatectomy and subsequent chemotherapy, leukemia developed following a 2 month preleukemic stage. Chromosomal analysis revealed an abnormal karyotype, 46,XX,-5, + der(5)t(3;5)(q25;q31). The balanced translocation t(3;5) has been observed in all types of ANLL and MDS except for ANLL M3 subtype. We summarize patients with ANLL M6 and t(3;5).
authors.affiliation: Third Department Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: T
authors.initials: T
authors.lastname: Takashima
authors.forename: Y
authors.initials: Y
authors.lastname: Shizumi
authors.forename: H
authors.initials: H
authors.lastname: Nishigaki
authors.forename: S
authors.initials: S
authors.lastname: Horiike
authors.forename: M
authors.initials: M
authors.lastname: Taniwaki
authors.forename: S
authors.initials: S
authors.lastname: Misawa
authors.forename: K
authors.initials: K
authors.lastname: Kashima
authors.forename: T
authors.initials: T
authors.lastname: Hironaka
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D002648:Child; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure*; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006498:Hepatectomy; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000235:genetics*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D014178:Translocation, Genetic
chemical_list: D003561:Cytarabine; D016685:Mitomycin; D015250:Aclarubicin; D004317:Doxorubicin; D011239:Prednisolone; D003630:Daunorubicin