Inhibition of baclofen-induced hypothermia in mice by the novel GABAB antagonist CGP 35348.
This study shows that the selective GABAB antagonist CGP 35348 had no effect on body temperature in mice in doses up to 300 mg/kg i.p. However, the highest dose abolished the hypothermia induced by the GABAB agonist baclofen (10 mg/kg i.p.) but not that produced by the GABA-mimetic progabide (200 mg/kg i.p.); the benzodiazepine agonist loprazolam (3 mg/kg i.p.); the alpha 2-agonist UK 14,304 (1 mg/kg i.p.) nor the mu-opioid agonist morphine (30 mg/kg i.p.). These findings, showing selective antagonism of GABAB receptors by CGP 35348, confirm that this compound may be a valuable tool for exploration of GABAB receptor function in vivo.
Jackson
H C
HC
Reckitt & Colman Psychopharmacology Unit, School of Medical Sciences, Bristol, England.
Nutt
D J
DJ
D000818:Animals; D001418:Baclofen / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D058787:GABA-A Receptor Antagonists; D007035:Hypothermia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009943:Organophosphorus Compounds / Q000494:pharmacology*
D058787:GABA-A Receptor Antagonists; D009943:Organophosphorus Compounds; C066430:CGP 35348; D001418:Baclofen