title: Effects of tentoxin and dihydrotentoxin on human erythrocytes.
abstract: The action of tentoxin and dihydrotentoxin on human erythrocytes was studied. It was found that both toxins increased membrane lipid fluidity as indicated by spin label fatty acid spectra. In contrast, tentoxin and dihydrotentoxin caused strongly expressed conformational changes of erythrocyte membrane proteins. Specific action of both toxins was found at the concentration of 0.01 mmol/l. Small changes of membrane lipid fluidity may be the result of lipid-protein interactions. Both toxins easily penetrate erythrocyte membrane and react with cytoplasmic proteins.
authors.affiliation: Department of Biophysics, University of Lódź, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Gwoździński
authors.forename: B
authors.initials: B
authors.lastname: Liebermann
authors.forename: I
authors.initials: I
authors.lastname: Dahse
mesh_terms: D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D008560:Membrane Fluidity; D008565:Membrane Proteins / Q000187:drug effects; D009183:Mycotoxins / Q000633:toxicity*; D010456:Peptides, Cyclic / Q000633:toxicity*
chemical_list: D008565:Membrane Proteins; D009183:Mycotoxins; D010456:Peptides, Cyclic; C073609:dihydrotentoxin; C003384:tentoxin