title: Detection of deep vein thrombosis: combined flow and blood pool radionuclide venography vs contrast venography.
abstract: This study was performed to validate the combined study of flow radionuclide venography (FRV) with subsequent 99mTc-red blood cell(RBC) blood pool radionuclide venography(BRV) for the detection of deep vein thrombosis (DVT). Findings in 32 patients with suspected DVT of lower extremities (n = 52) were compared with those of corresponding contrast venograms (CV) serving as a reference method. FRV was performed by using three separate doses of a large 99mTc04-bolus (10-12 cc) injection. The findings were as follows: concerning the detection of DVT in calf veins, agreement between FRV and CV, FRV+BRV and CV, and BRV and CV were 67%, 73% and 60%, respectively. For femoral veins, agreement between FRV and CV was 96%, while it was 87% between BRV and CV. When FRV and BRV of femoral veins were evaluated in combination, 100% agreement between radionuclide and radiologic method was observed. For iliac veins there was no disagreement in comparison of the methods either singly or in combination. In 7.6% of the extremities, collaterals not demonstrated by CV and BRV were visualized only by FRV. Although the radioactive agent was injected in a relatively large volume, all of the calf veins could not be filled even when they were completely patent. It was concluded that a combined study of FRV with BRV improved the diagnostic value of radionuclide venography for the detection of DVT in calf and femoral veins.
authors.affiliation: Department of Nuclear Medicine, Hacettepe University Medical School, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Caner
authors.forename: M
authors.initials: M
authors.lastname: Ozmen
authors.forename: A
authors.initials: A
authors.lastname: Dincer
authors.forename: O
authors.initials: O
authors.lastname: Kapucu
authors.forename: C
authors.initials: C
authors.lastname: Bekdik
mesh_terms: D000328:Adult; D003287:Contrast Media; D004912:Erythrocytes; D005260:Female; D005268:Femoral Vein; D006801:Humans; D007084:Iliac Vein; D007866:Leg / Q000098:blood supply; D008297:Male; D010690:Phlebography / Q000379:methods; D011875:Radionuclide Angiography / Q000379:methods; D013670:Sodium Pertechnetate Tc 99m; D013927:Thrombosis / Q000000981:diagnostic imaging*
chemical_list: D003287:Contrast Media; D013670:Sodium Pertechnetate Tc 99m