title: Ebselen prevents inositol (1,4,5)-trisphosphate binding to its receptor.
authors.affiliation: Faculty of Biology, University of Konstanz, Federal Republic of Germany.
authors.forename: S
authors.initials: S
authors.lastname: Dimmeler
authors.forename: B
authors.initials: B
authors.lastname: Brüne
authors.forename: V
authors.initials: V
authors.lastname: Ullrich
mesh_terms: D000813:Anilides / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels; D004220:Disulfides / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D016257:Fura-2; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D053496:Inositol 1,4,5-Trisphosphate Receptors; D054833:Isoindoles; D008861:Microsomes / Q000187:drug effects; D016566:Organoselenium Compounds; D015539:Platelet Activation / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear; D012643:Selenium / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D000813:Anilides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles; D015220:Calcium Channels; D004220:Disulfides; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D054833:Isoindoles; D016566:Organoselenium Compounds; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D013438:Sulfhydryl Compounds; C042986:ebselen; C068988:2-methylselenobenzanilide; D015544:Inositol 1,4,5-Trisphosphate; D006493:Heparin; D012643:Selenium; D002118:Calcium; D016257:Fura-2