title: Neoplasia associated with feline immunodeficiency virus infection in cats of southern California.
abstract: Between 1988 and 1991, feline immunodeficiency virus (FIV) infection status was evaluated in 1,160 cats examined at an oncology referral and general practice in Los Angeles, California. Twenty-nine (2.5%) cats were FIV positive. Neoplasia was present in 18 of the 29 (62%) cats. Sampling for neoplasia was intentionally biased in the oncology referral group. However, 33% (6/18) of FIV-infected cats with neoplasia originated from the general practice. Three neoplastic processes were observed; myeloproliferative disease (MPD; 5/18), lymphoma (LSA; 5/18), and squamous cell carcinoma (SCC; 7/18). One cat had LSA and SCC. Extranodal sites of LSA were common (66%) in FIV-infected cats. Sites of LSA were submandibular and mesenteric lymph nodes, liver, kidneys, periorbital area, and diffuse (heart, pancreas, bladder). Sites of SCC were sublingual (n = 2), nasal planum (n = 3), nasal planum and eyelids (n = 1), and mandible (n = 2). Feline leukemia virus co-infection was observed in 17% (5/29) of FIV-infected cats. The FIV-infected cats with MPD were young (range, 8 months to 13 years; median, 4 years) and had short survival duration (2, 6, 21, 134, 249 days) even in response to aggressive treatment. The FIV-infected cats with LSA were older (median age, 8 years; range, 4 to 14 years) and survived 60 days if untreated. Cats administered chemotherapy survived 39, 45, 217, and 243 days; the latter 2 cats had partial remission of 2 months' duration. Older FIV-infected cats had SCC (median age, 12 years; remission range, 7 to 16 years) because of more frequent association of both diseases in older cats with outdoor environment.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Animal Cancer Center, Hermosa Beach, CA 90254.
authors.forename: C A
authors.initials: CA
authors.lastname: Hutson
authors.forename: B A
authors.initials: BA
authors.lastname: Rideout
authors.forename: N C
authors.initials: NC
authors.lastname: Pedersen
mesh_terms: D000367:Age Factors; D000818:Animals; D002140:California / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D002371:Cat Diseases / Q000453:epidemiology* / Q000209:etiology; D002415:Cats; D005260:Female; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D016180:Lentivirus Infections / Q000150:complications / Q000453:epidemiology / Q000662:veterinary*; D008223:Lymphoma / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D008297:Male; D009196:Myeloproliferative Disorders / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*