title: Role of Na+/K+ exchange and organic acids in base induced hyperpolarization of renal proximal amphibian tubule.
abstract: Fast peritubular alkaline perturbations in Necturus renal proximal tubule evoke hyperpolarizations of the basolateral membrane. These voltage changes are partly due to an increase in basolateral K(+)-permeability. Additional role of the Na(+)/K(+)-ATPase and organic acids in generating these base induced hyperpolarizations (BIH) can be deduced from the reduction in BIH during low K+, high amiloride or omission of organic acids.
authors.affiliation: Departement WNIFysiologie, Limburgs Universitair Centrum, Diepenbeek, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Granitzer
authors.forename: P
authors.initials: P
authors.lastname: Steels
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002087:Butyrates / Q000378:metabolism; D020148:Butyric Acid; D007474:Ion Exchange; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000502:physiology; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D008564:Membrane Potentials; D009337:Necturus; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D000596:Amino Acids; D002087:Butyrates; D007773:Lactates; D020148:Butyric Acid; D019344:Lactic Acid; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium