Reduction of phosphoinositides and diacylglycerol levels in repeatedly dibutyltin-dilaurate-treated rat brain.
Oral administration of a single dose of dibutyltin dilaurate (DBTL, 80 mg/kg body wt.), 2 or 24 h after treatment, caused no significant change in the levels of diacylglycerol and phosphoinositides in rat cerebrum (forebrain), whereas daily administration of DBTL (40 or 80 mg/kg body wt.) for 3 days (24 h after the final treatment) decreased the levels of diacylglycerol and phosphoinositides (phosphatidylinositol, phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate) in a concentration-dependent manner without influencing the levels of phosphatidylcholine in rat cerebrum. These studies indicate impairment of the phosphoinositide messenger system in rat cerebrum following repeated exposure to DBTL.
Subramoniam
A
A
Industrial Toxicology Research Centre, Lucknow, India.
Husain
R
R
Seth
P K
PK
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004075:Diglycerides / Q000032:analysis*; D008297:Male; D009947:Organotin Compounds / Q000633:toxicity*; D010716:Phosphatidylinositols / Q000032:analysis*; D051381:Rats
D004075:Diglycerides; D009947:Organotin Compounds; D010716:Phosphatidylinositols; C010409:dibutyltin dilaurate