title: Identification of a diuretic hormone of Locusta migratoria.
abstract: We have isolated a peptide from brains and corpora cardiaca of Locusta migratoria which is immunologically related to the diuretic hormone of Manduca sexta. We determined its structure as a 46 amino acid linear peptide with 43-50% identity to the M. sexta hormone. Moreover, we showed that the new peptide functions as a diuretic hormone in L. migratoria, stimulating urine production by Malpighian tubules and elevating levels of cAMP in tubules.
authors.affiliation: Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Lehmberg
authors.forename: R B
authors.initials: RB
authors.lastname: Ota
authors.forename: K
authors.initials: K
authors.lastname: Furuya
authors.forename: D S
authors.initials: DS
authors.lastname: King
authors.forename: S W
authors.initials: SW
authors.lastname: Applebaum
authors.forename: H J
authors.initials: HJ
authors.lastname: Ferenz
authors.forename: D A
authors.initials: DA
authors.lastname: Schooley
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D000242:Cyclic AMP / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects; D006110:Grasshoppers; D007301:Insect Hormones / Q000302:isolation & purification* / Q000494:pharmacology; D008317:Malpighian Tubules / Q000187:drug effects; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis; D012689:Sequence Homology, Nucleic Acid; D014556:Urine
chemical_list: D007301:Insect Hormones; D009842:Oligopeptides; D000242:Cyclic AMP