title: Scintigraphic findings mimicking focal nodular hyperplasia in a case of hepatoblastoma.
abstract: Hepatoblastoma is a primary liver neoplasm in which prompt diagnosis and resection are critical to long-term survival. Liver scintigraphy using Tc-99m sulfur colloid and Tc-99m iminodiacetic acid (IDA) derivatives has been used in the evaluation of hepatic masses. Most space-occupying lesions of the liver appear as photopenic regions following either Tc-99m SC or IDA agents. Two exceptions have been reported. Focal nodular hyperplasia (FNH) has been shown to have variable colloid uptake, which is dependent upon the number of Kupffer cells per given volume. Many patients with FNH will demonstrate activity within the FNH to be greater or equal to the normal liver. In addition, two cases of hepatoblastoma have been reported to show colloid activity within the tumor, and in one patient slight uptake of Tc-99m IDA was noted in the tumor 15 minutes postinjection. The current case demonstrates a hepatoblastoma in which the scintigraphic findings with Tc-99m SC and Tc-99m IDA were similar to those reported, with retention of IDA far greater than the previously reported case.
authors.affiliation: Nuclear Medicine Department, Cedars-Sinai Medical Center, Los Angeles, California.
authors.forename: D E
authors.initials: DE
authors.lastname: Tanasescu
authors.forename: A D
authors.initials: AD
authors.lastname: Waxman
authors.forename: C
authors.initials: C
authors.lastname: Hurvitz
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D006965:Hyperplasia; D007098:Imino Acids; D007223:Infant; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D007098:Imino Acids; D015609:Organotechnetium Compounds; C046767:technetium Tc 99m iminodiacetic acid; D013671:Technetium Tc 99m Sulfur Colloid