Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
A female patient in whom acute nonlymphocytic leukemia (ANLL, FAB-M6) developed during treatment of hepatocellular carcinoma (HCC) is described. Two years after partial hepatectomy and subsequent chemotherapy, leukemia developed following a 2 month preleukemic stage. Chromosomal analysis revealed an abnormal karyotype, 46,XX,-5, + der(5)t(3;5)(q25;q31). The balanced translocation t(3;5) has been observed in all types of ANLL and MDS except for ANLL M3 subtype. We summarize patients with ANLL M6 and t(3;5).
Nakagawa
H
H
Third Department Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Tanaka
S
S
Takashima
T
T
Shizumi
Y
Y
Nishigaki
H
H
Horiike
S
S
Taniwaki
M
M
Misawa
S
S
Kashima
K
K
Hironaka
T
T
D015250:Aclarubicin / Q000008:administration & dosage; D000293:Adolescent; D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000150:complications; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D002648:Child; D002893:Chromosomes, Human, Pair 3 / Q000648:ultrastructure*; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D003561:Cytarabine / Q000008:administration & dosage; D003630:Daunorubicin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006498:Hepatectomy; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000235:genetics*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D014178:Translocation, Genetic
D003561:Cytarabine; D016685:Mitomycin; D015250:Aclarubicin; D004317:Doxorubicin; D011239:Prednisolone; D003630:Daunorubicin