[Effector modeling of the action of ligands of the GABA receptor complex: functional interactions of muscimol and exogenous modulators of the complex].
In comparison with the literature data the pharmacological effects of muscimol (MS) on mice organism were studied under the condition of administration of the exogenic ligands of GABA-receptor complex GABA antagonist bicuculline (BC), chloride ionophor blocking agent pentylenetetrazole (PZ), phenazepam (BD), sodium barbital (BB) and GABA synthesis antagonist--thiosemicarbazide (TS). Antagonism of MS to the anticonvulsant effect of BB and BD at the administration of BC to the animal was observed, while no effect was observed at the administration of PZ. However at the administration of TS to the experimental animals MS exhibits anticonvulsant effect. The observed properties (partial agonism/partial reverse agonism) of MS at its effect to the whole system are probably determined by the level of endogenic GABA and its changes due to the administration of TS and functional state of GABA--receptor system modified with the exogenic ligand BC.
Golovenko
N Ia
NIa
Zin'kovskiĭ
V G
VG
Zhuk
O V
OV
D000818:Animals; D014151:Anti-Anxiety Agents; D001462:Barbital / Q000494:pharmacology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D008024:Ligands; D008297:Male; D051379:Mice; D009118:Muscimol / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*; D012663:Semicarbazides / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D008024:Ligands; D011963:Receptors, GABA-A; D012663:Semicarbazides; D001569:Benzodiazepines; D009118:Muscimol; C017928:phenazepam; D001462:Barbital; C005151:thiosemicarbazide; D010433:Pentylenetetrazole; D001640:Bicuculline
Effektornoe modelirovanie deĭstviia ligandov GAMK-retseptornogo kompleksa: funktsional'noe vzaimodeĭstvie mustsimola i ékzogennykh moduliatorov kompleksa.