title: Mutations of the P53 gene, including an intronic point mutation, in colorectal tumors.
abstract: In this study, analysis of structural changes of the p53 gene in colorectal tumors revealed point mutations detected in 8 of 14 carcinomas and 2 of 2 adenomas. Of these 10 cases with point mutations, eight had one or more missense mutations, one had a nonsense mutation, and the remaining one had, interestingly, an intronic point mutation with subsequent activation of a cryptic splice donor site in the flanking exon. This report contains the first identification of an intronic point mutation of the p53 gene in a colorectal cancer case.
authors.affiliation: Department of Clinical Cancer Chemotherapy, Tohku University, Sendai, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Ishioka
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Gamoh
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Shibata
authors.forename: R
authors.initials: R
authors.lastname: Kanamaru
authors.forename: A
authors.initials: A
authors.lastname: Wakui
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D007700:Kinetics; D008761:Methylhistamines / Q000378:metabolism; D008969:Molecular Sequence Data; D011224:Prazosin / Q000378:metabolism; D011738:Pyrilamine / Q000378:metabolism; D011869:Radioligand Assay; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism; D011968:Receptors, Histamine / Q000302:isolation & purification / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism; D018100:Receptors, Histamine H3; D013569:Synapses / Q000502:physiology
chemical_list: D008761:Methylhistamines; D011942:Receptors, Adrenergic, alpha; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D018100:Receptors, Histamine H3; D011738:Pyrilamine; D011224:Prazosin; C048140:N-methylhistamine