title: Angiotensin-converting enzyme and other peptidolytic enzymes in human semen and relations to its spermatologic parameters.
abstract: Angiotensin-converting enzyme (ACE) and other enzymes of the renin-angiotensin system (RAS) occur in human semen in high activities. In contrast to bull ejaculates, not all zinc-dependent metallopeptidases are found to be in close correlation to the microscopically determined semen parameters; such a relationship was established only partly for the ACE. On the other hand, the RAS-dependent spermatozoa-bound enzymes, inclusive ACE, uniformly show negative correlations to the spermatologic parameters of human semen. These results, for the first time, point to different functions of the sperm-cell-bound (testicular) and of the seminal plasma (pulmonary) ACE activities.
authors.affiliation: Institute of Drug Research, Berlin, Germany.
authors.forename: W E
authors.initials: WE
authors.lastname: Siems
authors.forename: G
authors.initials: G
authors.lastname: Heder
authors.forename: H
authors.initials: H
authors.lastname: Hilse
authors.forename: I
authors.initials: I
authors.lastname: Baeger
authors.forename: S
authors.initials: S
authors.lastname: Engel
authors.forename: K D
authors.initials: KD
authors.lastname: Jentzsch
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D007248:Infertility, Male / Q000201:enzymology; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008666:Metalloendopeptidases / Q000378:metabolism; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D012661:Semen / Q000201:enzymology*; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000166:cytology / Q000201:enzymology / Q000502:physiology*; D015032:Zinc / Q000494:pharmacology
chemical_list: D007527:Isoenzymes; D007703:Peptidyl-Dipeptidase A; D008666:Metalloendopeptidases; D015032:Zinc