The usefulness of bronchoalveolar lavage in identifying past occupational exposure to asbestos: a light and electron microscopy study.
Fiberoptic bronchoscopy has permitted the development of lavage procedures for the collection of lung washes. In certain disease states this material may contain large numbers of phagocytic cells (macrophages and neutrophils). Since these phagocytes are the predominant "dust scavenger cells" in the lung, the assessment of their particulate burden as well as that of the overall lavage material has been suggested as a potentially important diagnostic tool. The studies to date have shown that the presence of ferruginous bodies is an indication of past occupational exposure. In the present study, a digestion procedure was carried out on bronchoalveolar lavage material collected from individuals who were occupationally exposed to asbestos and from samples obtained from the general population. The parameters used for distinguishing the source of these samples included both light microscopy assessment of the filters for the presence of ferruginous bodies and electron microscopic screening for the presence of uncoated fibers.
Dodson
R F
RF
Department of Cell Biology and Environmental Sciences, University of Texas Health Center, Tyler 75710.
Garcia
J G
JG
O'Sullivan
M
M
Corn
C
C
Levin
J L
JL
Griffith
D E
DE
Kronenberg
R S
RS
D000328:Adult; D000368:Aged; D001194:Asbestos / Q000032:analysis*; D017639:Asbestos, Amosite; D017632:Asbestos, Serpentine; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology*; D001999:Bronchoscopy; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016273:Occupational Exposure; D010586:Phagocytes / Q000473:pathology
D017632:Asbestos, Serpentine; D017639:Asbestos, Amosite; D001194:Asbestos