title: Mechanism of action of newly developed vitamin D analogue.
abstract: 26,27-F6-1,25(OH)2D3 has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo, instead of almost equal binding to 1,25(OH)2D3 receptor and comparatively short serum half-life. To date, the mechanism of higher action is not known, but using these analogues as a mirror we might be able to elucidate the mechanism of action or the metabolism of the kidney hormone, 1,25(OH)2D3.
authors.affiliation: First Department of Medicine, Nagasaki University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: E
authors.initials: E
authors.lastname: Ejima
authors.forename: T
authors.initials: T
authors.lastname: Kiriyama
authors.forename: M
authors.initials: M
authors.lastname: Izumi
authors.forename: A
authors.initials: A
authors.lastname: Komori
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Katsumata
authors.forename: A
authors.initials: A
authors.lastname: Nagata
mesh_terms: D000818:Animals; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D002118:Calcium / Q000097:blood; D006801:Humans; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid / Q000378:metabolism; D005466:Fluorocarbons
chemical_list: D002117:Calcitriol; D002118:Calcium; D018167:Receptors, Calcitriol; D011987:Receptors, Steroid; C040488:26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D3; D005466:Fluorocarbons