title: Long-term potentiation, protein kinase C, and glutamate receptors.
abstract: Among the various molecular events that have been proposed to contribute to the mechanisms of long-term potentiation (LTP), one of the most cited possibilities has been the activation of protein kinase C (PKC). Here we review various aspects of the cellular actions of PKC activation and inhibition, with special emphasis on the effects of the kinase on synaptic transmission and the N-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated components of synaptic responses. We discuss the implications of these effects for interpretations of the role of PKC in the mechanisms of LTP induction and maintenance.
authors.affiliation: Department of Pharmacology, Centre Medical Universitaire, Geneva, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Muller
authors.forename: P A
authors.initials: PA
authors.lastname: Buchs
authors.forename: L
authors.initials: L
authors.lastname: Stoppini
authors.forename: H
authors.initials: H
authors.lastname: Boddeke
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010703:Phorbol Esters / Q000494:pharmacology; D011493:Protein Kinase C / Q000502:physiology*; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000502:physiology*; D015398:Signal Transduction; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D010703:Phorbol Esters; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D011493:Protein Kinase C