title: In vitro effect of nonsteroidal antiinflammatory drugs on proteoglycanase and collagenase activity in human osteoarthritic cartilage.
abstract: The effects of several nonsteroidal antiinflammatory drugs, used at concentrations achievable in synovial fluid, on human osteoarthritic (OA) cartilage metallo-protease activity in vitro was studied. Acetaminophen and ketoprofen had no effect; sodium salicylate, indomethacin, and diclofenac slightly decreased proteoglycanase activity. Piroxicam and tenoxicam suppressed proteoglycanase activity by 48.2% and 68.3%, respectively, and suppressed collagenase activity by 19.1% and 36.8%, respectively. Use of these NSAIDs may help to decrease cartilage catabolism in patients with OA.
authors.affiliation: Department of Rheumatology, Edouard Herriot Hospital, Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Vignon
authors.forename: P
authors.initials: P
authors.lastname: Mathieu
authors.forename: P
authors.initials: P
authors.lastname: Louisot
authors.forename: M
authors.initials: M
authors.lastname: Richard
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002358:Cartilage, Articular / Q000201:enzymology*; D004008:Diclofenac / Q000494:pharmacology; D010450:Endopeptidases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007660:Ketoprofen / Q000494:pharmacology; D008297:Male; D008666:Metalloendopeptidases; D003012:Microbial Collagenase / Q000378:metabolism*; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000188:drug therapy* / Q000201:enzymology*; D010894:Piroxicam / Q000031:analogs & derivatives / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology; D020156:Salicylic Acid
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D012459:Salicylates; D010894:Piroxicam; D004008:Diclofenac; D000082:Acetaminophen; D007660:Ketoprofen; D010450:Endopeptidases; C022474:proteoglycan-degrading metalloendopeptidases; D008666:Metalloendopeptidases; D003012:Microbial Collagenase; D020156:Salicylic Acid; D007213:Indomethacin; C032801:tenoxicam