Pentamidine activates T1 the hepatic microsomal glucose 6-phosphate transport protein of the glucose-6-phosphatase system.
The mechanism of activation of hepatic microsomal glucose-6-phosphatase (EC 3.1.3.9) in vitro by pentamidine has been investigated in both intact and fully disrupted microsomes. The major effect of pentamidine is a 4.7-fold reduction in the Km of glucose-6-phosphatase activity in intact diabetic rat liver microsomes. The site of action of pentamidine is T1 the hepatic microsomal glucose 6-phosphate transport protein. The activation of T1 by pentamidine may contribute to the disturbed blood glucose homeostasis seen in many patients after the administration of the drug pentamidine.
Scott
H M
HM
Department of Obstetrics and Gynaecology, Centre for Research into Human Development, Ninewells Hospital and Medical School, University of Dundee, U.K.
Burchell
A
A
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D004789:Enzyme Activation; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D015394:Molecular Structure; D010419:Pentamidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002352:Carrier Proteins; D005958:Glucosephosphates; D019298:Glucose-6-Phosphate; D010419:Pentamidine; D005952:Glucose-6-Phosphatase