Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.
Concentrations of 3'-fluoro-3'-deoxythymidine (FDT) and 3'-deoxy-2',3'-didehydrothymidine (D4T) in plasma declined in a biexponential fashion. Total clearance of D4T (1.75 +/- 0.22 liters/h/kg; mean +/- standard deviation) was significantly greater than that of FDT (1.19 +/- 0.19 liters/h/kg) owing to greater renal and nonrenal clearances of the former. Steady-state volumes of distribution of FDT (1.20 +/- 0.12 liters/kg) and D4T (1.07 +/- 0.15 liters/kg) were similar.
Boudinot
F D
FD
Department of Pharmaceutics, College of Pharmacy, University of Georgia, Athens 30602.
Smith
S G
SG
Funderburg
E D
ED
Schinazi
R F
RF
D000818:Animals; D000998:Antiviral Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D015224:Dideoxynucleosides / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D018119:Stavudine
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D018119:Stavudine; C002854:alovudine