[Experimental study of the protective effects of N-acetylcysteine on endotoxin-induced acute lung injury].
The purpose of this study was to investigate the effects of NAC (N-acetylcysteine) on endotoxin induced acute lung injury in unanesthetized sheep. The results showed that NAC attenuated the responses to endotoxemia, and the rise in pulmonary artery pressure was significantly diminished, and the rise of TXB2 and 6-keto-PGF1 alpha in plasma and lung lymph was less significantly for NAC + E than for E alone. The QL (lung lymph flow), PC (lung lymph protein clearance) and PS (pulmonary capillary surface permeability area) were significantly decreased in NAC + E group. The lipid peroxide contents in artery plasma and lung lymph were not increased in NAC-treated group. We conclude that NAC is capable of attenuating all pathophysiologic changes after endotoxin infusion, blocking the reaction of oxygen free radicals, and protecting lungs from oxidant damage.
Zhu
Y
Y
D000818:Animals; D003553:Cystine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004731:Endotoxins; D004926:Escherichia coli; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008171:Lung Diseases / Q000209:etiology / Q000517:prevention & control*; D008196:Lymph / Q000378:metabolism; D012756:Sheep; D014115:Toxemia / Q000150:complications*
D004731:Endotoxins; D008054:Lipid Peroxides; D003553:Cystine; C030905:N-monoacetylcystine