title: Suppression of tumorigenicity in Wilms tumor by the p15.5-p14 region of chromosome 11.
abstract: Wilms tumor has been associated with genomic alterations at both the 11p13 and 11p15 regions. To differentiate between the involvement of these two loci, a chromosome 11 was constructed that had one or the other region deleted, and this chromosome was introduced into the tumorigenic Wilms tumor cell line G401. When assayed for tumor-forming activity in nude mice, the 11p13-deleted, but not the 11p15.5-p14.1-deleted chromosome, retained its ability to suppress tumor formation. These results provide in vivo functional evidence for the existence of a second genetic locus (WT2) involved in suppressing the tumorigenic phenotype of Wilms tumor.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California, Irvine 92717.
authors.forename: S F
authors.initials: SF
authors.lastname: Dowdy
authors.forename: C L
authors.initials: CL
authors.lastname: Fasching
authors.forename: D
authors.initials: D
authors.lastname: Araujo
authors.forename: K M
authors.initials: KM
authors.lastname: Lai
authors.forename: E
authors.initials: E
authors.lastname: Livanos
authors.forename: B E
authors.initials: BE
authors.lastname: Weissman
authors.forename: E J
authors.initials: EJ
authors.lastname: Stanbridge
mesh_terms: D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D016162:Genes, Wilms Tumor / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000235:genetics*; D051379:Mice; D008819:Mice, Nude; D009396:Wilms Tumor / Q000235:genetics*