[The reaction to hypoxia of ATP-sensitive K+ channels in rat cardiomyocytes].
The responses of ATP-sensitive K(+)-channels of the adult rat's cardiomyocytes to simulated hypoxia were found to have an oscillatory character. The degree of its blocking was found to depend on the ATP concentration at the inner side of the membrane. The concentration of the semi-maximal blocking is not more than 20 mcM. The necessity to take into consideration the local intracellular changes of the macroerg content for explanation of the revealed responses, is discussed.
Babenko
A P
AP
Samoĭlov
V O
VO
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D015221:Potassium Channels; D000255:Adenosine Triphosphate
Izuchenie reaktsii na gipoksiiu ATF-chuvstvitel'nykh K+-kanalov kardiomiotsitov krysy.