Vascular access ports for chronic serial infusion and blood sampling in New Zealand white rabbits.
Although rabbit ear vessels are readily accessible, the veins can collapse and thrombose after multiple venipunctures, and the artery may undergo vasospasm when repeatedly catheterized. Twenty-two male and female New Zealand White rabbits were cannulated with the catheter tip located in the jugular vein. The mean life of the port was noted to be approximately 3.5 months, with ranges of 3 days to 10 months. With proper maintenance and care, vascular access ports are a useful alternative to multiple venipuncture for long-term studies, thereby sparing marginal and central vessels and minimizing stress to both animals and investigators.
Perry-Clark
L M
LM
Department of Laboratory Animal Science, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406.
Meunier
L D
LD
D000818:Animals; D001800:Blood Specimen Collection / Q000295:instrumentation / Q000379:methods; D002408:Catheters, Indwelling; D005260:Female; D007262:Infusions, Intravenous; D007601:Jugular Veins; D008297:Male; D008722:Methods; D011817:Rabbits