A high incidence of cough associated with combination therapy of hypertension with isradipine and lisinopril in Chinese subjects.
The efficacy and tolerability of combination therapy using Lisinopril (5-20 mg om) and Isradipine (1.25 mg-2.50 mg bd) was assessed in 29/50 Chinese subjects, whose blood pressures were not controlled on Isradipine alone. The addition of Lisinopril produced approximately two-fold reductions in blood pressure compared to Isradipine alone, increasing the responder rate of the original cohort of 50 subjects by 18% and normalization rate, by 32%. No significant changes in haematological or biochemical parameters, CXR or ECG, were observed. However, use of Lisinopril in our subjects was associated with a high incidence of cough (48%), possibly limiting its use in this population.
Woo
J
J
Department of Medicine, Chinese University of Hong Kong.
Chan
T Y
TY
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced; D004095:Dihydropyridines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D017275:Isradipine; D017706:Lisinopril; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D004095:Dihydropyridines; D004656:Enalapril; D017706:Lisinopril; D017275:Isradipine