Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II.
Casein kinase II is involved in the phosphorylation of several proto-oncogenes, anti-oncogenes, and oncogenes that are nuclear transcriptional regulatory factors. The potential functions of the phosphorylations in each of these proteins are evaluated. New findings indicate that casein kinase II is a critical component of the mechanisms regulating the cell cycle.
Meisner
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Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 10605.
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D017456:Adenovirus Early Proteins; D000595:Amino Acid Sequence; D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000378:metabolism; D047388:Casein Kinases; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000378:metabolism; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D020598:Proto-Oncogene Proteins c-myb; D011988:Receptors, Thyroid Hormone; D013379:Substrate Specificity; D014157:Transcription Factors / Q000378:metabolism*
D017456:Adenovirus Early Proteins; D000952:Antigens, Polyomavirus Transforming; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D020598:Proto-Oncogene Proteins c-myb; D011988:Receptors, Thyroid Hormone; D014157:Transcription Factors; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases; D047388:Casein Kinases