Fate of oligodendrocytes in HIV-1 infection.
The brains of 22 HIV-1-infected cases and 11 controls, matched for age and sex, were studied with immunocytochemical reactions specific for oligodendrocytes, astrocytes, microglia and HIV-1. In HIV-1 infection, mild degrees of myelin damage were associated with an increase in oligodendrocyte numbers, a change that was reversed in the presence of severe damage. Severity of myelin damage correlated with the extent of astrocytic and microglial reactions expressed in a semi-quantitative manner. HIV-1 p24 antigen was detected in all cases with severe myelin damage and a smaller proportion of cases with lesser degrees of myelin damage. It is concluded that, in HIV-1 infection, oligodendrocytes undergo an initial reactive hyperplasia which may represent an attempt to repair myelin damage.
Esiri
M M
MM
University Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.
Morris
C S
CS
Millard
P R
PR
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000032:analysis; D000163:Acquired Immunodeficiency Syndrome / Q000382:microbiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001253:Astrocytes / Q000382:microbiology / Q000473:pathology; D001921:Brain / Q000382:microbiology; D002256:Carbonic Anhydrases / Q000032:analysis; D003711:Demyelinating Diseases / Q000382:microbiology / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D016655:HIV Core Protein p24 / Q000032:analysis; D015658:HIV Infections / Q000382:microbiology / Q000473:pathology*; D015497:HIV-1; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009836:Oligodendroglia / Q000201:enzymology / Q000382:microbiology / Q000473:pathology*; D012276:Ricin
D005904:Glial Fibrillary Acidic Protein; D016655:HIV Core Protein p24; D012276:Ricin; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D002256:Carbonic Anhydrases