[The extracellular matrix of peripheral lung cancer in the scar and of pneumosclerosis of different origins (the immunohistochemistry and electron microscopy of the collagens)].
Collagen types and ultrastructural features of the stroma and scar extracellular matrix in the peripheral lung carcinoma, post-tuberculosis and post-pneumonia pneumosclerosis foci, fibrosing alveolitis interstitium were studied on the material of operational and transbronchial lung biopsies. It is established that by the collagen composition the scars in the peripheral carcinoma are identical to the pneumosclerosis foci and are distinguished from the carcinoma stroma by a higher concentration of type IV and V collagens (p less than 0.05). Accumulation of type III collagen in the lung carcinoma stroma reflects anaplasia of the tumour as the domination of type III collagen is characteristic of the embryonal tissue. The decrease of collagen type IV in the cancer stroma correlates with an increase of its malignancy. Pneumosclerosis in the fibrosing alveolitis is distinct from the focal forms of pneumosclerosis by a higher content of collagen I and a lower content of collagen V this being probably due to the character of sclerosis morphogenesis in this disease.
Kogan
E A
EA
Sekamova
S M
SM
Tseĭtlin
A M
AM
Shukurova
R A
RA
Ovchinnikov
A A
AA
Rodionov
K V
KV
Trishkina
N V
NV
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D002276:Carcinoid Tumor / Q000378:metabolism / Q000473:pathology; D002921:Cicatrix / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000378:metabolism / Q000648:ultrastructure*; D008169:Lung Abscess / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000378:metabolism / Q000473:pathology; D012598:Sclerosis / Q000378:metabolism / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000378:metabolism / Q000473:pathology
D003094:Collagen
Ekstratselliuliarnyĭ matriks perifericheskogo raka legkogo v rubtse i pnevmoskleroza razlichnogo proiskhozhdeniia (immunogistokhimiia i élektronnaia mikroskopiia kollagenov).