Doxorubicin cardiotoxicity detected by indium 111 myosin-specific imaging.
A patient with primary hepatoma, treated with doxorubicin and presenting with atypical electrocardiographic findings, was investigated with myosin-specific monoclonal antibody radiolabelled with indium-111. Despite a normal ejection fraction, myosin-specific scintigraphy was positive, indicating doxorubicin cardiotoxicity.
Lekakis
J
J
Department of Clinical Therapeutics, Athens University, Greece.
Vassilopoulos
N
N
Psichoyiou
H
H
Athanassiadis
P
P
Gerali
S
S
Kostamis
P
P
Moulopoulos
S
S
D000368:Aged; D000911:Antibodies, Monoclonal; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D006321:Heart / Q000000981:diagnostic imaging*; D006331:Heart Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D007205:Indium Radioisotopes; D008113:Liver Neoplasms / Q000188:drug therapy; D008297:Male; D009942:Organometallic Compounds; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D007205:Indium Radioisotopes; D009942:Organometallic Compounds; C058899:imciromab pentetate; D004317:Doxorubicin