Influence of heat stimulation on the amount of calcitonin gene-related peptide and neurokinin A in the subcutaneous space of the rat hind instep.
The release of tachykinins and calcitonin gene-related peptide (CGRP) into subcutaneous perfusates was investigated. Immersion of the hind paw of rats in water at 47 degrees C for 30 min led to a marked increase of immunoreactive CGRP (iCGRP) release as well as immunoreactive substance P release, but no detectable increase of immunoreactive neurokinin A release. Neonatal pretreatment with capsaicin or section of the sciatic and the saphenous nerves significantly inhibited the heat stimulation-induced release of iCGRP.
Yonehara
N
N
Department of Pharmacology, Faculty of Dentistry, Osaka University, Japan.
Imai
Y
Y
Inoki
R
R
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D006358:Hot Temperature; D007101:Immersion; D008297:Male; D015288:Neurokinin A / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D015288:Neurokinin A; D015740:Calcitonin Gene-Related Peptide