Reactive hypoglycaemia in association with disordered islet function and abnormal hepatic glucose-6-phosphatase activity: response to diazoxide.
Severe reactive hypoglycaemia was confirmed in a non-diabetic male patient by a counter-regulatory hormone (GH, cortisol and catecholamine) response to profound hypoglycaemia induced by an intravenous glucose load. There was also evidence of disordered pancreatic islet cell paracrine regulation with hyperinsulinaemia and absent glucagon response to hypoglycaemia. A defect in the patient's hepatic glucose-6-phosphatase enzyme system was documented. Because of severe symptoms, dietary control was insufficient, but the patient responded clinically and biochemically to 18 months of oral diazoxide therapy. He also showed good biochemical response to a single dose (100 micrograms IM) of the somatostatin analogue octreotide.
Pears
J
J
Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK.
Jung
R T
RT
Browning
M C
MC
Taylor
R
R
Burchell
A
A
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003981:Diazoxide / Q000627:therapeutic use*; D005934:Glucagon / Q000097:blood; D005951:Glucose Tolerance Test; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007003:Hypoglycemia / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone; D005934:Glucagon; D005952:Glucose-6-Phosphatase; D003981:Diazoxide; D006854:Hydrocortisone