Epinephrine potentiates activation of human platelets by low density lipoproteins.
Low density lipoproteins activate phosphoinositide turnover, increase free cytoplasmic calcium concentration and stimulate phosphorylation of 20- and 47-kDa proteins in blood platelets. All these effects are substantially potentiated by epinephrine.
Bochkov
V N
VN
Institute of Experimental Cardiology, Cardiology Research Center, Moscow, U.S.S.R.
Voino-Yasenetskaya
T A
TA
Tkachuk
V A
VA
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D004789:Enzyme Activation; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism; D010766:Phosphorylation; D015539:Platelet Activation / Q000187:drug effects*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D010738:Type C Phospholipases / Q000378:metabolism
D001798:Blood Proteins; D008077:Lipoproteins, LDL; D010716:Phosphatidylinositols; D000244:Adenosine Diphosphate; D010738:Type C Phospholipases; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium; D004837:Epinephrine