title: In vivo detection of metabolic changes in a mouse model of scrapie using nuclear magnetic resonance spectroscopy.
abstract: In vivo proton nuclear magnetic resonance (NMR) spectroscopy studies of scrapie in a mouse model have shown the appearance of an abnormal peak in the brain early in the incubation period. This abnormal peak was detected weeks before the detection of a protease-resistant form of a membrane protein and vacuolar histopathology in vitro, and several months before clinical signs, and the signal increased in intensity as the disease progressed. In the chronic stage of the disease, a reduction in N-acetyl aspartate levels was observed using in vivo and in vitro proton NMR spectroscopy.
authors.affiliation: NMR Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
authors.forename: J D
authors.initials: JD
authors.lastname: Bell
authors.forename: I J
authors.initials: IJ
authors.lastname: Cox
authors.forename: S C
authors.initials: SC
authors.lastname: Williams
authors.forename: P S
authors.initials: PS
authors.lastname: Belton
authors.forename: I
authors.initials: I
authors.lastname: McConnell
authors.forename: J
authors.initials: J
authors.lastname: Hope
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D004195:Disease Models, Animal; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010472:Perchlorates / Q000737:chemistry / Q000378:metabolism; D012608:Scrapie / Q000378:metabolism*
chemical_list: D010472:Perchlorates