[Lysosomotropic compounds inhibiting the multiplication of Junin virus].
A number of lysosomotropic compounds of diverse chemical structure, ammonium chloride, procaine and chlorpheniramine, were found to inhibit the infection of Vero cells by Junín virus. Viral replication was almost totally inhibited by 15 mM ammonium chloride, when added either before or within the first hour of infection and a significant inhibition (97.8%) was observed when it was added 8 hours after infection. These results agree with a model which postulates that arenavirus entry occurs by receptor-mediated endocytosis.
Castilla
V
V
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Mersich
S E
SE
Damonte
E B
EB
D000643:Ammonium Chloride / Q000494:pharmacology*; D000818:Animals; D006477:Arenaviruses, New World / Q000187:drug effects* / Q000502:physiology; D002744:Chlorpheniramine / Q000494:pharmacology*; D003864:Depression, Chemical; D004705:Endocytosis / Q000187:drug effects; D008247:Lysosomes / Q000187:drug effects; D011343:Procaine / Q000494:pharmacology*; D011991:Receptors, Virus / Q000187:drug effects; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
D011991:Receptors, Virus; D000643:Ammonium Chloride; D002744:Chlorpheniramine; D011343:Procaine
Compuestos lisosomotrópicos inhibidores de la multiplicación del virus Junín.