The role of reactive oxygen species, cytokines and cytochrome P450 in pulmonary damage due to hyperoxia.
The exact mechanism of hyperoxic damage and the (therapeutic) protection against these lesions are still a matter of debate. Recent experimental studies indicated a role for cytokines, cytochrome P450, and antioxidant enzymes in protection against O2 toxicity. In this paper a hypothesis is presented linking all these factors to cytochrome P450 oxidase as a central enzyme.
Sprong
C
C
Department of Occupational and Environmental Health and Toxicology, University of Limburg, Maastricht, Holland.
Janssen
Y M
YM
Borm
P J
PJ
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology*; D016207:Cytokines / Q000502:physiology*; D004731:Endotoxins / Q000494:pharmacology; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000378:metabolism; D015227:Lipid Peroxidation; D008171:Lung Diseases / Q000139:chemically induced*; D051379:Mice; D008954:Models, Biological; D009251:NADPH-Ferrihemoprotein Reductase; D010088:Oxidoreductases / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D013481:Superoxides / Q000378:metabolism; D013552:Swine
D016207:Cytokines; D004731:Endotoxins; D005609:Free Radicals; D013481:Superoxides; D003577:Cytochrome P-450 Enzyme System; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D009251:NADPH-Ferrihemoprotein Reductase; D010100:Oxygen