[Tumor suppressor genes: occurrence, significance and function].
Tumor-suppressor-genes were detected by DNA-analysis of childhood tumors. A homozygous deletion or mutation of these genes is closely associated with different malignant tumors. Tumor-suppressor-genes seem to play an important role in cellular development and differentiation. The understanding of this pathomechanism in cancerogenesis is most important for calculating a genetic risk for tumor development.
Scheurlen
W
W
Universitäts-Kinderklinik Würzburg.
Kreth
H W
HW
D014408:Biomarkers, Tumor / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D002872:Chromosome Deletion; D005134:Eye Neoplasms / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000235:genetics*; D012175:Retinoblastoma / Q000235:genetics; D009396:Wilms Tumor / Q000235:genetics
D014408:Biomarkers, Tumor
Tumorsuppressorgene: Vorkommen, Bedeutung und Funktion.