[3 cases of Kituchi's lymphadenitis in systemic lupus erythematosus. Role of the parvovirus B19].
Florid necrotizing lymphadenitis, characterized by segmental infarction and lymphoid hyperplasia, is an uncommon feature of systemic lupus erythematosus (SLE). Kikuchi's disease is a well-defined clinicopathological entity, with a strong preference for the cervical lymph nodes of young women. The etiology of histiocytic necrotizing lymphadenitis (HNL) remains unknown, although viral agents have been proposed. HNL may reflect a self-limited SLE-like autoimmune disease but full-blown SLE associated with this condition has not, to the best of our knowledge, been reported. Thus, ours is the first description of the coexistence of SLE and HNL in 3 patients with immunologically proven parvovirus B19 infections. SLE and HNL were diagnosed simultaneously in 2 patients, but was retrospective in the third, in whom anti-tuberculous therapy was ineffective. Patients 1 and 2 were treated with prednisone (1 mg/kg/d) and responded rapidly. These data suggest that both HNL and SLE flares can be caused by parvovirus B19 infection.
Meyer
O
O
Clinique de Rhumatologie/Universitè, Paris VII.
Ribard
P
P
Belmatoug
N
N
Kahn
M F
MF
Grossin
M
M
Fournet
J C
JC
Darne
C
C
Morinet
F
F
D000328:Adult; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008199:Lymphadenitis / Q000145:classification / Q000209:etiology* / Q000382:microbiology; D008875:Middle Aged; D009336:Necrosis; D010322:Parvoviridae Infections
Trois cas de lymphadénite de Kikuchi au cours du lupus érythémateux systémique. Rôle du parvovirus B19.