title: Antibodies to gag gene coded polypeptides of type D retroviruses in healthy people from Guinea-Bissau.
abstract: Antibodies to proteins of Mason-Pfizer monkey virus (M-PMV) were screened in sera from 61 healthy donors living in Guinea-Bissau (4 HIV-1 and HIV-2 antibody positive HIV = human immunodeficiency virus), from 19 healthy French European blood donors, and from 9 French patients with induced immunodeficiency prior to bone marrow transplantation (all HIV-1 antibody negative). In 30 (49%) of the African sera tested, antibodies reacting against p27 and/or p14 were detected by western blot. Some of these cases were confirmed to be positive using radioimmuno precipitation assay. Only one serum from a French blood donor was detected by western blot to be slightly positive against p27 M-PMV. Thirty-two sera screened for M-PMV were also tested for squirrel monkey retrovirus by western blot. In eight (25%) sera antibodies at least against p36 were detected. Among squirrel monkey retrovirus positive sera, three were also positive with p27 M-PMV. The other five were found to be M-PMV negative.
authors.affiliation: UPR 0043 CNRS, Université Paris VII, Hôpital Saint-Louis, France.
authors.forename: V A
authors.initials: VA
authors.lastname: Morozov
authors.forename: F
authors.initials: F
authors.lastname: Saal
authors.forename: A
authors.initials: A
authors.lastname: Gessain
authors.forename: A
authors.initials: A
authors.lastname: Terrinha
authors.forename: J
authors.initials: J
authors.lastname: Périès
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D015153:Blotting, Western; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005602:France; D015750:Genes, gag / Q000276:immunology*; D006169:Guinea-Bissau; D015483:HIV Antibodies / Q000276:immunology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000276:immunology; D006801:Humans; D008297:Male; D016093:Mason-Pfizer monkey virus / Q000276:immunology*; D015531:Radioimmunoprecipitation Assay; D015301:Retroviruses, Simian / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D015483:HIV Antibodies; D014764:Viral Proteins