title: The biological activity of atrial natriuretic factor cleaved by endoprotease 3.4.24.11.
abstract: Ring cleavage of atrial natriuretic peptide (ANF) between Cys7 and Phe8 by endoprotease 3.4.24.11 yields X-ANF. Since endoprotease 3.4.24.11 may contribute to ANF metabolism in vivo, the present study determined if X-ANF exhibits reduced biological activity in comparison to the parent molecule.
authors.affiliation: Research Department, CIBA-GEIGY Corporation, Summit, New Jersey 07901.
authors.forename: R D
authors.initials: RD
authors.lastname: Ghai
authors.forename: R L
authors.initials: RL
authors.lastname: Webb
authors.forename: J L
authors.initials: JL
authors.lastname: Sonnenberg
authors.forename: Y
authors.initials: Y
authors.lastname: Sakane
authors.forename: G
authors.initials: G
authors.lastname: Ghai
mesh_terms: D000302:Adrenal Cortex / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology*; D009320:Atrial Natriuretic Factor / Q000378:metabolism / Q000494:pharmacology*; D002417:Cattle; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009318:Natriuresis / Q000187:drug effects; D015260:Neprilysin / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D017461:Receptors, Atrial Natriuretic Factor; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D010446:Peptide Fragments; D011956:Receptors, Cell Surface; C068964:X-atrial natriuretic factor; D009320:Atrial Natriuretic Factor; D015260:Neprilysin; D017461:Receptors, Atrial Natriuretic Factor