title: Unsaturated phosphatidylcholines inhibit superoxide production in human neutrophils.
abstract: Unsaturated long chain phosphatidylcholines such as phosphatidylcholine dioleoyl and phosphatidylcholine dilinoleoyl in micromolar concentrations inhibited the superoxide production in neutrophils stimulated by the activators of protein kinase C, phorbol 12-myristate 13-acetate and 1,2-dioctanoyl-sn- glycerol. In contrast, the superoxide production induced by surface receptor agonist, formyl-methionyl-leucyl-phenylalanine, was unaffected by the phospholipids. These data suggest that surfactant phosphatidylcholines may have a modulatory role on neutrophil oxidative burst in the lung during inflammation where there is a preponderance of unsaturated phosphatidylcholines.
authors.affiliation: John B. Pierce Laboratory, Yale University School of Medicine, New Haven, Connecticut 06519.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: V
authors.initials: V
authors.lastname: Mohsenin
mesh_terms: D000704:Analysis of Variance; D002458:Cell Fractionation; D004075:Diglycerides / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011494:Protein Kinases / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D004075:Diglycerides; D010713:Phosphatidylcholines; C044295:1,2-dioctanoylglycerol; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D011494:Protein Kinases; D013755:Tetradecanoylphorbol Acetate