title: Effects of intra-amygdaloid TRH injections on motor activity and dominant-submissive behavior in rats competing for water.
abstract: The effect of thyrotropin releasing hormone (TRH) microinjections into the central amygdala (10 g in 0.5 1 into each side) on locomotor activity water intake and dominance behavior in a water competition test was investigated in male Wistar rats. TRH increased the general motility without altering the number of rearings. Intra-amygdaloid TRH injection to submissive rats resulted in a loss of subordinate position in these animals in the water competition test. A tendency to decrease dominance followed the injection of the peptide to the dominant animals. The effect of TRH in the dominance test does not appear to involve influence on the thirst drive as microinjection of the peptide did not change significantly the water consumption in thirsty rats.
authors.affiliation: Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warsaw.
authors.forename: O
authors.initials: O
authors.lastname: Puciłowski
authors.forename: E
authors.initials: E
authors.lastname: Trzaskowska
authors.forename: E
authors.initials: E
authors.lastname: Jankowska
authors.forename: W
authors.initials: W
authors.lastname: Kostowski
authors.forename: G
authors.initials: G
authors.lastname: Kupryszewski
mesh_terms: D000679:Amygdala / Q000033:anatomy & histology / Q000502:physiology*; D000818:Animals; D003163:Competitive Behavior / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012930:Social Dominance; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D013973:Thyrotropin-Releasing Hormone