title: Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation.
abstract: Among 289 pregnancies in which chorion villus sampling (CVS) was carried out at 56-66 days' gestation, 5 babies with severe limb abnormalities were subsequently identified. 4 had oromandibular-limb hypogenesis syndromes, and the other had a terminal transverse limb reduction defect. This high incidence raises the possibility that CVS was an aetiological factor for these developmental anomalies.
authors.affiliation: Department of Medical Genetics, Churchill Hospital, Oxford, UK.
authors.forename: H V
authors.initials: HV
authors.lastname: Firth
authors.forename: P A
authors.initials: PA
authors.lastname: Boyd
authors.forename: P
authors.initials: P
authors.lastname: Chamberlain
authors.forename: I Z
authors.initials: IZ
authors.lastname: MacKenzie
authors.forename: R H
authors.initials: RH
authors.lastname: Lindenbaum
authors.forename: S M
authors.initials: SM
authors.lastname: Huson
mesh_terms: D000015:Abnormalities, Multiple / Q000209:etiology*; D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D017880:Limb Deformities, Congenital; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013577:Syndrome