title: Beta-receptor regulation: dynamics of density and function throughout the cardiac cycle.
abstract: Recent research shows beta-receptors in human myocardium can lose sensitivity to endogenous and exogenous stimulation. This decreased sensitivity known as down-regulation, explains several therapy. The clinical phenomena of concern to nursing and helps predict patient response to therapy. The concept of lusitropy (process of relaxation) and the use of pharmacologic beta-modulators are added to the traditional hemodynamic framework as integral parts of a new dynamic model.
authors.forename: R K
authors.initials: RK
authors.lastname: Gibson
mesh_terms: D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000187:drug effects* / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects* / Q000502:physiology; D012106:Research
chemical_list: D011943:Receptors, Adrenergic, beta