Secondary generalization in kainic acid-induced focal seizures in unanesthetized cats.
Seizure propagation was studied with different seizure models induced by a kainic acid (KA) microinjection in nonanesthetized cats. These seizures were characterized with a focal onset of seizures followed by secondarily generalized seizures. The mesencephalic reticular formation (MRF) played an important role when an epileptogenic focus was located in a unilateral amygdala, hippocampus, thalamus or visual cortex. When the focus was located in a unilateral lateral geniculate body, a fast, synchronous and bidirectional propagation was observed in the sensorimotor cortex (SMC) and MRF. Brain stem seizure (generalized tonic seizure) was elicited by the KA injection into MRF. The EEG of generalized seizure was characterized by the propagations of seizure activities of MRF immediately to the bilateral SMC and thalamus. The results suggested that MRF participated actively in the generalization of the KA-induced seizures.
Tanaka
T
T
Department of Neurosurgery, Asahikawa Medical College, Japan.
Fujita
T
T
Tanaka
S
S
Araki
T
T
Yonemasu
Y
Y
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D001931:Brain Mapping; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000503:physiopathology*; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D007608:Kainic Acid; D008032:Limbic System / Q000187:drug effects / Q000503:physiopathology; D008636:Mesencephalon / Q000187:drug effects / Q000503:physiopathology; D009434:Neural Pathways / Q000187:drug effects / Q000503:physiopathology; D012154:Reticular Formation / Q000187:drug effects / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D013787:Thalamic Nuclei / Q000187:drug effects / Q000503:physiopathology
D007608:Kainic Acid