title: Comparison of plain and alkalinized local anaesthetic mixtures of lignocaine and bupivacaine for elective extradural caesarean section.
abstract: We have examined a local anaesthetic mixture of 0.5% bupivacaine 10 ml and 2% lignocaine 10 ml with adrenaline 1 in 200,000, to which 8.4% sodium bicarbonate 2 ml was added, for extradural Caesarean section. The alkalinized mixture of local anaesthetics produced a block of more rapid onset and density than a mixture of bupivacaine and lignocaine alone (P less than 0.001).
authors.affiliation: Department of Anaesthetics, Royal Gwent Hospital, Newport.
authors.forename: R
authors.initials: R
authors.lastname: Fernando
authors.forename: H M
authors.initials: HM
authors.lastname: Jones
mesh_terms: D000328:Adult; D000767:Anesthesia, Epidural; D000773:Anesthesia, Obstetrical; D001639:Bicarbonates / Q000008:administration & dosage / Q000494:pharmacology; D002045:Bupivacaine / Q000008:administration & dosage* / Q000494:pharmacology; D002585:Cesarean Section; D004311:Double-Blind Method; D004837:Epinephrine / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000494:pharmacology; D011247:Pregnancy; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology; D017693:Sodium Bicarbonate
chemical_list: D001639:Bicarbonates; D017693:Sodium Bicarbonate; D008012:Lidocaine; D012964:Sodium; D002045:Bupivacaine; D004837:Epinephrine