Induction of signet ring cell carcinomas in X-irradiated hypocatalasemic mice (C3H/Cbs).
The stomach region of hypocatalasemic mice of both sexes was X-irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P less than 0.01 in males and P less than 0.05 in females) compared to a total absence of similar tumors in the non-irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs.
Watanabe
H
H
Department of Cancer Research, Hiroshima University.
Ogundigie
P O
PO
Takahashi
T
T
Ishimoto
T
T
Ito
A
A
D020642:Acatalasia; D000230:Adenocarcinoma / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D000818:Animals; D005260:Female; D008207:Lymphatic Metastasis; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D012727:Sex Characteristics; D013274:Stomach Neoplasms / Q000473:pathology*; D014965:X-Rays