title: Ocular-systemic interrelationships in acquired immunodeficiency syndrome.
abstract: We analysed the correlation between ophthalmic and systemic findings in 125 subjects with AIDS and 50 subjects with AIDS-related complex (ARC). Positive eye findings were defined as the presence of cotton-wool spots (CWS) or cytomegalovirus (CMV) retinitis. The presence of positive eye findings was significantly more frequent in AIDS than in ARC (P = 0.0001). Both lowest haematocrit and lowest T-helper cell count were significantly lower in AIDS than in ARC, and also lower in subjects with positive eye findings than in those with negative eye findings. No association was found between ocular findings and the following: risk factors for human immunodeficiency virus (HIV) transmission; positive titres for CMV, herpes simplex, Epstein-Barr virus (EBV), and toxoplasmosis; systemic infections; and intake of azidothymidine (AZT). Patients with AIDS and CWS were similar to patients with AIDS and CMV retinitis in viral serology, haematocrit, T-helper count, and survival. Positive eye findings, low haematocrit, and low T-helper count are poor prognostic signs for survival in AIDS.
authors.affiliation: Department of Ophthalmology, University of Texas Medical Branch, Galveston 77550.
authors.forename: A M
authors.initials: AM
authors.lastname: Mansour
authors.forename: T
authors.initials: T
authors.lastname: Uchida
authors.forename: G
authors.initials: G
authors.lastname: Rodenko
authors.forename: R
authors.initials: R
authors.lastname: Dutt
mesh_terms: D000386:AIDS-Related Complex / Q000097:blood / Q000150:complications*; D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D011446:Prospective Studies; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000737:chemistry; D013781:Texas