RP 49356: inhibitory effects of ionic and secretory events in rat pancreatic islets.
Rp 49356, a 'K+ channel opener', inhibited 86Rb outflow, 45Ca outflow and insulin release from glucose-stimulated islets perifused in the presence of Ca2+. The drug lost its capacity to reduce 86Rb outflow in islets exposed to glucose-free or Ca(2+)-free medium. These observations suggest that RP 49356 might exhibit antagonistic actions on B-cell Ca2+ channels. This will, in turn, reduce glucose-stimulated insulin output and Ca(2+)-dependent 86Rb outflow.
Lebrun
P
P
Laboratory of Pharmacology, Free University of Brussels, School of Medicine, Belgium.
Antoine
M H
MH
Hermann
M
M
Herchuelz
A
A
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects; D007328:Insulin / Q000378:metabolism*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D010477:Perfusion; D010847:Picolines / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D011714:Pyrans / Q000494:pharmacology*; D051381:Rats
D015220:Calcium Channels; D007328:Insulin; D010847:Picolines; D011714:Pyrans; C061043:aprikalim; D011188:Potassium; D002118:Calcium