Peripheral serotonergic markers in patients with suicidal behavior.
Peripheral serotonergic parameters were studied in 17 patients with a history of suicidal behavior and in 17 age- and sex-matched healthy controls. Serotonin2 receptor function in platelets, measured as serotonin-induced [32P]phosphatidylinositol 4,5-bisphosphate hydrolysis, was significantly higher in patients than in age- and sex-matched controls. Increased serotonin2 receptor transduction was not correlated to psychiatric diagnosis, drug treatment or a history of violent suicide attempt. Monoamine oxidase activity was lower in platelets from patients with a history of suicidal behavior than in controls. In addition, whole blood serotonin was analyzed but no significant alterations were found in blood from patients.
Simonsson
P
P
Department of Psychiatry, Lund University, Sweden.
Träskman-Bendz
L
L
Alling
C
C
Oreland
L
L
Regnéll
G
G
Ohman
R
R
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates / Q000097:blood; D010743:Phospholipids / Q000097:blood; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000097:blood*; D015398:Signal Transduction; D013405:Suicide
D015415:Biomarkers; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010743:Phospholipids; D011985:Receptors, Serotonin; D012701:Serotonin; D008995:Monoamine Oxidase