Laryngeal carcinoma associated with human papillomavirus type 16.
The advent of molecular hybridization technology has provided evidence supporting human papillomavirus as an etiologic agent of laryngeal carcinoma. Using Southern blot analysis, we identified human papillomavirus type 16 DNA associated with an invasive laryngeal carcinoma. The virus genome did not appear to be integrated into the host genome, as is often the case with anogenital tumors. Laryngeal carcinoma usually arises on the true vocal cords of individuals who demonstrate demographic and lifestyle risk factors for this cancer. The patient, an adult male, has no identifiable risk factors for laryngeal carcinoma other than papillomavirus infection. Our finding suggests that the application of hybridization analysis to all cases of laryngeal cancer would promote understanding of the association between human papillomavirus and laryngeal carcinoma.
McCullough
D W
DW
Department of Otolaryngology, University of Manitoba, Winnipeg, Canada.
McNicol
P J
PJ
D000328:Adult; D015139:Blotting, Southern; D002277:Carcinoma / Q000382:microbiology*; D002278:Carcinoma in Situ / Q000382:microbiology; D004279:DNA, Viral / Q000032:analysis; D005814:Genes, Viral; D006801:Humans; D007822:Laryngeal Neoplasms / Q000382:microbiology*; D008297:Male; D010212:Papilloma / Q000382:microbiology; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics; D010957:Plasmids; D014412:Tumor Virus Infections
D004279:DNA, Viral