title: The sources of genetic variability in highly inbred long-term selected strains of Drosophila melanogaster.
abstract: A highly inbred, long-term selected for low fitness strain LA of Drosophila melanogaster possesses a significant mutational load and unusually high rates of spontaneous mutability as revealed by CyL/Pm method. Our results indicate that during cross of CyL/Pm to LA strains, destabilization of copia-like and mobile elements and induction of H-E hybrid dysgenesis take place. The role of these processes in causing considerable genetic variability of LA strain is discussed.
authors.affiliation: Department of Genetics and Breeding, Leningrad State University, USSR.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Kaidanov
authors.forename: V N
authors.initials: VN
authors.lastname: Bolshakov
authors.forename: P N
authors.initials: PN
authors.lastname: Tzygvintzev
authors.forename: V A
authors.initials: VA
authors.lastname: Gvozdev
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D005804:Genes, Lethal / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D014644:Genetic Variation; D007178:Inbreeding; D007246:Infertility / Q000235:genetics; D008297:Male; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012641:Selection, Genetic
chemical_list: D004251:DNA Transposable Elements