[Lipid peroxidation and antioxidative activity in the tumor tissue and blood of patients with neuro-oncological diseases].
Study of the content of products of lipid peroxidation, total lipid antioxidation activity, and superoxide dismutase activity in the tissue and blood of 31 patients (23 with gliomas and 8 with meningiomas) showed the level of malonic dialdehyde (MDA) in the tumor tissue to be significantly lower statistically than in the cerebral tissue. The MDA content was much lower in meningiomas than in gliomas. No essential differences were revealed in the MDA level in benign and malignant gliomas. This value correlated well with the total lipid antiperoxidation activity which was twice higher in tumor tissue than in the cerebral tissue and higher in meningiomas than in the tissue of gliomas. Superoxide dismutase activity was statistically significantly higher in the cerebral tissue than in all other tumor tissues studied. The blood plasma MDA level is higher in patients with gliomas than in the blood of donors while lipid antioxidation activity is lower. In the group of patients with meningiomas the blood plasma MDA level increases with reduction of superoxide dismutase activity, which may be evidence of its role in this process.
Levchenko
L I
LI
Demchuk
M L
ML
D000293:Adolescent; D000328:Adult; D000975:Antioxidants; D001932:Brain Neoplasms / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000032:analysis; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000378:metabolism; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000378:metabolism*; D008579:Meningioma / Q000737:chemistry / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism
D000975:Antioxidants; D008055:Lipids; D008315:Malondialdehyde; D013482:Superoxide Dismutase
Perekisnoe oksilenie i antiokislitel'naia aktivnost' lipidov v opukholevoĭ tkani i krovi bol'nykh s neĭroonkologicheskimi zabolevaniiami.