[Synaptic architectonics of the molecular layer of the cerebral cortex of rats with audiogenic epileptiform seizures during regulation of the convulsive readiness of the brain].
Using electron microscopy and morphometry it has been demonstrated in Krushinsky-Molodkina rats that brain convulsive preparedness (BCP) in audiogenic irritations is determined in many respects by the status of the plastic mechanisms of spines in axospine synapses. For the determination of the BCP threshold of essential importance is the magnitude of the free surface of a spine (FSS) on which there depend the size and shape of the spine cervix and the magnitude of the ratio of the FSS to the size of the active area of the contact (ACC). As the BCP is dramatically raised by means of sensitization with brain extract antigens, the AAC noticeably increases, and the FSS/AAC is reduced. Marked lowering of the BCP due to the use of cyclophosphamide is accompanied by the minimum size of the FSS and the minimum FSS/AAC ratio (spine hypoplasia).
Ereniev
S I
SI
Stepanov
S S
SS
Semchenko
V V
VV
D000161:Acoustic Stimulation; D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008854:Microscopy, Electron; D009044:Motor Cortex / Q000187:drug effects / Q000648:ultrastructure*; D051381:Rats; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D013003:Somatosensory Cortex / Q000187:drug effects / Q000648:ultrastructure*; D013569:Synapses / Q000187:drug effects / Q000648:ultrastructure*
D003520:Cyclophosphamide
Sinaptoarkhitektonika molekuliarnogo sloia kory bol'shogo mozga krys pri audiogennykh épileptiformnykh pripadkakh na fone reguliatsii urovnia sudororozhnoĭ gotovnosti mozga.