The effect of bicuculline and baclofen on the dorsal root-ventral root reflex in the isolated spinal cord.
1. In the lumbar spinal cord, 10(-6) M bicuculline reduces the inhibition of the dorsal root-ventral root (DR-VR) reflex produced by lateral stimulation of the spinal cord. The inhibition returns on washing in control artificial cerebrospinal fluid (ACSF). 2. Baclofen (10(-6) M) inhibits the monosynaptic DR-VR reflex which returns on washing in control ACSF. 3. This suggests an involvement of GABAA receptors in the lateral inhibition and GABAB receptors in the DR-VR reflex system. 4. The increased activity seen following bicuculline or tubocurarine probably resets the "set point" of neural activity to a lower level.
al-Zamil
Z
Z
Department of Neurophysiology, The Medical School, Southampton University, England.
Bagust
J
J
Kerkut
G A
GA
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology*; D006224:Cricetinae; D004566:Electrodes; D066298:In Vitro Techniques; D008647:Mesocricetus; D011963:Receptors, GABA-A / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*; D012023:Reflex, Monosynaptic / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*; D014403:Tubocurarine / Q000494:pharmacology
D011963:Receptors, GABA-A; D001418:Baclofen; D014403:Tubocurarine; D001640:Bicuculline