P.O.E.M.S. syndrome with complete recovery after treatment of a solitary plasmocytoma.
The P.O.E.M.S. syndrome is a rare clinical entity that has been described mainly in Japan. It is characterized by a progressive polyneuropathy with raised CSF protein content, organomegaly, endocrinopathy, skin changes and plasma cell dyscrasia. We report a new documented case associated with a solitary plasmocytoma of the 12th thoracic vertebra. Immunopathological and ultrastructural studies of the peripheral nerve did not disclose any immune-specific changes. Surgery and radiation therapy of the plasmocytoma allowed a complete recovery, with a 5-year follow-up. This case report illustrates the need for serial full skeletal survey, including scintigraphy, in middle-aged patients with progressive polyneuropathy of obscure origin.
Broussolle
E
E
Clinique Neurologique, Hôpital Neurologique, Lyon, France.
Vighetto
A
A
Bancel
B
B
Confavreux
C
C
Pialat
J
J
Aimard
G
G
D001847:Bone Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D004700:Endocrine System Diseases / Q000150:complications* / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006529:Hepatomegaly / Q000150:complications / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D010265:Paraproteinemias / Q000150:complications* / Q000378:metabolism; D010525:Peripheral Nerves / Q000378:metabolism / Q000503:physiopathology; D010954:Plasmacytoma / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D011115:Polyneuropathies / Q000150:complications* / Q000378:metabolism; D011859:Radiography; D011877:Radionuclide Imaging; D012871:Skin Diseases / Q000150:complications* / Q000378:metabolism; D013577:Syndrome
D002556:Cerebrospinal Fluid Proteins