Maternal-fetal transmission of SIV in macaques: disseminated adenovirus infection in an offspring with congenital SIV infection.
To develop a nonhuman primate model for maternal-fetal transmission of HIV infection, we have inoculated pregnant Macaca nemestrina with uncloned SIVMne. Three animals inoculated during the third trimester delivered healthy infants. One of the three infants, a male born 31 days after the mother was inoculated with SIV, became virus-positive but failed to produce SIV-specific antibody and died with overt simian immunodeficiency and disseminated adenovirus (SV20) infection at age six and one-half months. SIV and adenovirus antigen could be demonstrated by immunohistochemical methods in multiple organ systems.
Ochs
H D
HD
Department of Pediatrics, University of Washington School of Medicine, Seattle 98195.
Morton
W R
WR
Tsai
C C
CC
Thouless
M E
ME
Zhu
Q
Q
Kuller
L D
LD
Wu
Y P
YP
Benveniste
R E
RE
D000257:Adenoviridae Infections / Q000150:complications* / Q000473:pathology; D000261:Adenoviruses, Simian / Q000276:immunology / Q000302:isolation & purification; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000473:pathology; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D005260:Female; D008099:Liver / Q000473:pathology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008213:Lymphocyte Activation; D008254:Macaca nemestrina; D008297:Male; D010179:Pancreas / Q000382:microbiology / Q000473:pathology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications / Q000151:congenital / Q000473:pathology / Q000635:transmission*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification*
D000956:Antigens, Viral