Antidepressants and brain respiration.
Imipramine and clorgyline, at concentrations of 0.002 M, inhibit the respiration of brain tissue by 82 and 71 per cent respectively, while chloropromazine and tranylcypromine, at concentrations of 0.01 M, inhibit it about 25 per cent. Deprenyl and amphetamine at a concentration of 0.002 M inhibit brain tissue respiration by 12 and 18 per cent respectively. Respiration in brain is least affected by lithium chloride (only 5 per cent inhibition).
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Indian Institute of Chemical Biology, Calcutta.
Nandi
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D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002712:Chlorides / Q000494:pharmacology; D002746:Chlorpromazine / Q000494:pharmacology; D003010:Clorgyline / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D007099:Imipramine / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D018021:Lithium Chloride; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D014191:Tranylcypromine / Q000494:pharmacology
D000928:Antidepressive Agents; D002712:Chlorides; D012642:Selegiline; D014191:Tranylcypromine; D008094:Lithium; D000661:Amphetamine; D018021:Lithium Chloride; D005947:Glucose; D003010:Clorgyline; D007099:Imipramine; D002746:Chlorpromazine