Detection of transient capacitance increase associated with channel formation in lipid bilayers.
The insertion of alpha- and beta-latrotoxins and sea anemone (Radianthus macrodactilus) toxin into bilayer lipid membranes (BLMs) was investigated using the method of simultaneous conductance/capacitance measurement. All the toxins investigated induced capacitance changes which preceded toxin-induced conductance increases. The processes that may underlie the observed effect are discussed.
Chanturiya
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A.V. Palladin Biochemistry Institute, Kiev, U.S.S.R.
D000818:Animals; D001180:Arthropod Venoms / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003064:Cnidarian Venoms / Q000494:pharmacology*; D004553:Electric Conductivity; D007473:Ion Channels; D008051:Lipid Bilayers; D008563:Membrane Lipids; D008564:Membrane Potentials; D012615:Sea Anemones; D013111:Spider Venoms / Q000494:pharmacology*
D001180:Arthropod Venoms; D003064:Cnidarian Venoms; D007473:Ion Channels; D008051:Lipid Bilayers; D008563:Membrane Lipids; D013111:Spider Venoms; C020763:alpha-latrotoxin; C056637:beta-latrotoxin