[Studies on defence effects of recombinant human granulocyte colony-stimulating factor (G-CSF) to infections. I. Induction of neutrophil polarization by G-CSF].
It is well known that recombinant human granulocyte increases dramatically the number of granulocytes in peripheral blood. It is interesting to see if G-CSF enhances the functions of neutrophil since the neutrophil is one of the most important factors of host defence mechanism against infections. In this study, we have demonstrated that G-CSF induced the polarization of neutrophil while it could not be chemoattractant for the cell. Polarization is considered to be the initial reaction of chemotaxis. Therefore, G-CSF might enhance the defence effect of the neutrophils+ to infections in this point.
Second Department of Internal Medicine, Nagasaki University School of Medicine.
M
M
Hirota
J
J
Kadota
K
K
Tomono
R
R
Senju
K
K
Fukushima
K
K
Hiratani
Y
Y
Dotsu
K
K
Komori
S
S
Kohno
K
K
Yamaguchi
D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D003115:Colony-Stimulating Factors / Q000502:physiology*; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D007113:Immunity, Innate; D009504:Neutrophils / Q000502:physiology*
D003115:Colony-Stimulating Factors; D016179:Granulocyte Colony-Stimulating Factor