Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: induction of tumors in three macaques.
The carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to 37 months. Metastases to the lung occurred in two of the three monkeys. Microscopically, the hepatocellular carcinoma in all three cases demonstrated a trabecular pattern. These data demonstrate that IQ is a potent carcinogen in nonhuman primates and support the idea that it is a potential carcinogen for humans.
National Cancer Institute, Bethesda, Maryland 20892.
R H
RH
Adamson
U P
UP
Thorgeirsson
E G
EG
Snyderwine
S S
SS
Thorgeirsson
J
J
Reeves
D W
DW
Dalgard
S
S
Takayama
T
T
Sugimura
D000818:Animals; D002273:Carcinogens; D005260:Female; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary; D008252:Macaca fascicularis; D008297:Male; D011804:Quinolines / Q000633:toxicity*; D000509:alpha-Fetoproteins / Q000378:metabolism
D002273:Carcinogens; D011804:Quinolines; D000509:alpha-Fetoproteins; C029216:2-amino-3-methylimidazo(4,5-f)quinoline