Biological effects of staphylococcal protein A immunotherapy in cats with induced feline leukemia virus infection.
Biological effects of staphylococcal protein A (SPA) immunotherapy were studied in 5 viremic and 6 nonviremic cats with induced FeLV infection and in 6 control cats. The SPA therapy neither reversed FeLV viremia nor resulted in consistent improvement in humoral immune responses to FeLV antigens. However, SPA immunotherapy induced a proliferative response in bone marrow granulocytic lineage, possibly resulting in expression of FeLV-free mature neutrophils in the blood. Seemingly, viral burden and chemiluminescent responses were reversed in viremic cats during SPA immunotherapy.
Lafrado
L J
LJ
Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Mathes
L E
LE
Zack
P M
PM
Olsen
R G
RG
D000818:Animals; D002371:Cat Diseases / Q000209:etiology / Q000628:therapy*; D002415:Cats; D005260:Female; D007372:Interferons; D005256:Leukemia Virus, Feline; D007942:Leukemia, Experimental / Q000209:etiology / Q000628:therapy*; D008297:Male; D009504:Neutrophils / Q000502:physiology; D011897:Random Allocation; D013047:Specific Pathogen-Free Organisms; D013205:Staphylococcal Protein A / Q000627:therapeutic use*; D014766:Viremia / Q000209:etiology / Q000628:therapy / Q000662:veterinary*
D013205:Staphylococcal Protein A; D007372:Interferons