Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
D000595:Amino Acid Sequence; D004352:Drug Resistance, Microbial; D015684:Gene Products, pol; D005814:Genes, Viral; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D016297:Mutagenesis, Site-Directed; D012194:RNA-Directed DNA Polymerase / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000235:genetics; D015678:Viral Structural Proteins / Q000235:genetics; D014779:Virus Replication / Q000187:drug effects*; D015215:Zidovudine / Q000494:pharmacology* / Q000627:therapeutic use
D015684:Gene Products, pol; D011993:Recombinant Fusion Proteins; D015678:Viral Structural Proteins; D015215:Zidovudine; D012194:RNA-Directed DNA Polymerase