Aetiologic study on an influenza-like epidemic in horses in China.
About thirty thousands horses were affected and hundreds of them died in an epidemic caused by equine 2 influenza virus (H3N8) in China. The estimated morbidity and mortality accounted for 81% and 2%, respectively. The viral protein and RNA electrophoresis patterns revealed that the new isolates were antigenically different from the prototype strain influenza A/eq/Miami/1/63(H3N8). Therefore, the representative strain of the equine 2 subtype of influenza A virus recommended for producing reference reagents, vaccines, and for serological diagnosis must have been altered by antigenic drift.
Guo
Y J
YJ
Institute of Virology, Chinese Academy of Preventive Medicine, Beijing.
Wang
M
M
Zheng
S L
SL
Wang
P
P
Ji
W J
WJ
Chen
Q H
QH
D000818:Animals; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks / Q000662:veterinary*; D006734:Horse Diseases / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D006736:Horses; D009980:Influenza A virus / Q000235:genetics / Q000302:isolation & purification; D009976:Orthomyxoviridae Infections / Q000209:etiology / Q000401:mortality / Q000662:veterinary*; D012367:RNA, Viral / Q000032:analysis; D014764:Viral Proteins / Q000235:genetics
D012367:RNA, Viral; D014764:Viral Proteins