Dopaminergic neurons expressing calbindin in normal and parkinsonian monkeys.
In cynomolgus monkeys, midbrain neurons immunoreactive (IR) for the calcium-binding protein calbindin D-28k (CaBP) occur principally in the dorsal tier of substantia nigra pars compacta (SNc) and in the ventral tegmental area (VTA), and most of these neurons co-express tyrosine hydroxylase (TH). In monkeys rendered parkinsonian (PD) after MPTP injections, CaBP-IR neurons are much less severely affected than TH-IR neurons in SNc and in VTA, and most spared neurons in SNc/VTA display both CaBP and TH immunoreactivity. These results reveal that, in contrast to the situation in other neurodegenerative diseases, CaBP may be used as a marker for a specific neuronal population that is less prone to degeneration in Parkinson's disease.
Lavoie
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Centre de recherche en neurobiologie, Hôpital de l'Enfant-Jésus, Université Laval, Québec, Canada.
Parent
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D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D064026:Calbindins; D004298:Dopamine / Q000378:metabolism*; D007150:Immunohistochemistry; D008252:Macaca fascicularis; D008636:Mesencephalon / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D009928:Organ Specificity; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D012016:Reference Values; D064030:S100 Calcium Binding Protein G / Q000032:analysis / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism*
D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine