The origin of ovarian neuropeptide Y (NPY)-immunoreactive nerve fibres from the inferior mesenteric ganglion in the pig.
Applying a double-immunofluorescence technique, the porcine ovary is demonstrated to receive two populations of NPY-immunoreactive nerve fibres originating from the inferior mesenteric ganglion: one with colocalized tyrosine hydroxylase and supplying predominantly the ovarian vasculature, and a second, solely NPY-immunoreactive and almost exclusively associated with growing follicles. A third group of tyrosine hydroxylase- and dopamine-beta-hydroxylase-positive, but NPY-negative nerve fibres is associated with ovarian blood vessels and, to a minor extent, with ovarian follicles. As revealed by retrograde tracing, the vast majority of postganglionic neurons projecting to the ovary is located in a discrete area of the ganglion, suggesting a somatotopic organization of the porcine inferior mesenteric ganglion. Moreover, the findings indicate that three subpopulations of postganglionic sympathetic neurons with different chemical codes supply different target components of the porcine ovary. The physiological relevance of the described neurons in the nervous control of ovarian functions remains to be elucidated.
Institut für Anatomie und Zellbiologie der Universität, Heidelberg, Federal Republic of Germany.
M
M
Majewski
C
C
Heym
D000818:Animals; D015415:Biomarkers; D004299:Dopamine beta-Hydroxylase / Q000032:analysis; D004525:Efferent Pathways; D005260:Female; D005728:Ganglia, Sympathetic / Q000737:chemistry*; D009419:Nerve Tissue Proteins / Q000032:analysis; D009474:Neurons / Q000737:chemistry; D009478:Neuropeptide Y / Q000032:analysis*; D010053:Ovary / Q000098:blood supply / Q000294:innervation*; D013045:Species Specificity; D013552:Swine / Q000033:anatomy & histology*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D015415:Biomarkers; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase