[The pharmacokinetics of dihydrostreptomycin sulfate in domestic pigeons (Columba livia Gmel., 1789 var. domestica)].
A 20% aqueous solution of dihydrostreptomycin sulfate in a dosage of 100 mg/kg b.w. is non-toxic for pigeons, although renal accumulation occurs. 12 hours after a single subcutaneous injection of 100 mg/kg b.w. the plasma concentration decreases to 3.64 micrograms/ml and therefore below the therapeutically effective concentration, while in birds suffering from salmonella infections plasma levels decrease to comparative concentrations (3.84 micrograms/ml) after only 8 hours. Contrary to the directions for use in pigeons of the preparation CX 60, the subsequent dosage should be given no later than 10 hours after the first application.
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Institut für Geflügelkrankheiten, Ludwig-Maximilians-Universität München.
D000818:Animals; D001715:Bird Diseases / Q000378:metabolism*; D010856:Columbidae / Q000378:metabolism*; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D007279:Injections, Subcutaneous / Q000662:veterinary; D007668:Kidney / Q000378:metabolism; D012481:Salmonella Infections, Animal / Q000378:metabolism*
D004096:Dihydrostreptomycin Sulfate
Zur Pharmakokinetik von Dihydrostreptomycinsulfat bei Haustauben (Columba livia Gmel., 1789 var. domestica).