Correlation of Pityosporum ovale density with clinical severity of seborrheic dermatitis as assessed by a simplified technique.
One hundred patients with facial seborrheic dermatitis and 42 control subjects were studied. The number of periodic acid-Schiff-positive Pityosporum ovale yeast cells in skin scrapings per high-power field were counted and designated 1 + to 4 +. Our data indicate a correlation between the density of P. ovale and the clinical severity of seborrheic dermatitis, both before and after therapy with a precipitated sulfur/salicyclic acid shampoo. The data support the concept that yeast contributes to the pathogenesis of seborrheic dermatitis.
Department of Medicine, University of California, Los Angeles.
M C
MC
Heng
C L
CL
Henderson
D C
DC
Barker
G
G
Haberfelde
D000279:Administration, Cutaneous; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D012628:Dermatitis, Seborrheic / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D005148:Facial Dermatoses / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008290:Malassezia / Q000187:drug effects / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000008:administration & dosage / Q000627:therapeutic use; D013194:Staining and Labeling; D013455:Sulfur / Q000008:administration & dosage / Q000627:therapeutic use
D012459:Salicylates; D013455:Sulfur