Studies on antiparasitic agents: effect of the lactam nucleus substitution in the 2-position on the in-vitro activity of new 5-nitroimidazoles.
The in-vitro antiprotozoal activity of a series of new 5-nitroimidazoles substituted in the 2-position via a lactam nucleus was studied. All these compounds exhibited a better effect than metronidazole and structure-activity relationships are discussed.
Vanelle
P
P
Laboratoire de Chimie Organique, Faculté de Pharmacie, Marseille, France.
Maldonado
J
J
Gasquet
M
M
Delmas
F
F
Timon-David
P
P
Jentzer
O
O
Crozet
M P
MP
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004748:Entamoeba histolytica / Q000187:drug effects; D009593:Nitroimidazoles / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000981:Antiprotozoal Agents; D009593:Nitroimidazoles