Effects of phosphatidylserine therapy in geriatric patients with depressive disorders.
The effects of phosphatidylserine (BC-PS) on cognitive, affective and behavioural symptoms were studied in a group of 10 elderly women with depressive disorders. Patients were treated with placebo for 15 days, followed by BC-PS (300 mg/day) for 30 days. The Hamilton Rating Scale for Depression, Gottfries-Bråne-Steen Rating Scale, Nurse's Observation Scale for Inpatient Evaluation and Buschke Selective Reminding Test were administered before and after placebo and after BC-PS therapy, to monitor changes in depression, memory and general behaviour. At the same time, basal plasma levels of noradrenaline, MHPG, DOPAC, HVA and 5-HIAA, and GH/beta-endorphin/beta-lipotropin responses to clonidine stimulation were measured. BC-PS induced consistent improvement of depressive symptoms, memory and behaviour. No changes in amine metabolite levels or in hormonal responses to alpha 2-adrenoceptor stimulation were observed.
Clinica Zucchi, Università Milano, Italy.
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Maggioni
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Picotti
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Bondiolotti
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Panerai
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Cenacchi
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Nobile
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Brambilla
D015102:3,4-Dihydroxyphenylacetic Acid / Q000097:blood; D000368:Aged; D000369:Aged, 80 and over; D001143:Arousal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D002986:Clinical Trials as Topic; D003000:Clonidine; D003866:Depressive Disorder / Q000097:blood / Q000523:psychology / Q000628:therapy*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D009638:Norepinephrine / Q000097:blood; D010718:Phosphatidylserines / Q000008:administration & dosage*; D011941:Receptors, Adrenergic / Q000187:drug effects; D012008:Recurrence; D001615:beta-Endorphin / Q000097:blood; D008083:beta-Lipotropin / Q000097:blood
D010718:Phosphatidylserines; D011941:Receptors, Adrenergic; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D001615:beta-Endorphin; D013006:Growth Hormone; D008083:beta-Lipotropin; D003000:Clonidine; D009638:Norepinephrine; D006719:Homovanillic Acid