Cytogenetic study of blood in women who had used oral contraceptives.
Changes in the number and structure of chromosomes in peripheral lymphocytes of 31 healthy women using oral contraceptives (OC) were studied. Blood samples were taken prior to and after one, two and three months of using oral contraceptives. No significant differences were found in evaluating numerical anomalies but highly significant differences were detected in structural aberrations and in structural aberrations without gaps.
Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
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Fridrichová
D000328:Adult; D002715:Chlormadinone Acetate / Q000009:adverse effects; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects*; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000009:adverse effects; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D008656:Mestranol / Q000009:adverse effects; D009640:Norethindrone / Q000009:adverse effects / Q000031:analogs & derivatives; D009644:Norgestrel / Q000009:adverse effects; D011003:Ploidies; D011374:Progesterone / Q000009:adverse effects / Q000031:analogs & derivatives
D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D002715:Chlormadinone Acetate; D009644:Norgestrel; D004997:Ethinyl Estradiol; D011374:Progesterone; C039950:norbiogest; C010260:Non-Ovlon; D019304:Ethinyl Estradiol-Norgestrel Combination; C010336:sterolibrin; D008656:Mestranol; D009640:Norethindrone