Effect of recombinant human alpha interferon (INF) and antilymphocyte globulin (ALG) on normal and aplastic anaemia haematopoietic progenitor cell growth.
The effect of recombinant alpha interferon (INF) and of antilymphocyte globulin (ALG) to the colony stimulating factor (CSF) production was examined with in vitro culture of the bone marrow of healthy and of aplastic anaemia (AA) persons. In healthy persons the supernatant of lymphocytes preincubated with PHA and ALG was found to show a stimulating effect to clonogenic properties of marrow progenitors, the mentioned effect being not in proportion to the concentration value. Similar properties are shown by interferon in these persons. In patients with aplastic anaemia, a considerable stimulating ALG effect to the granulocytic formation of colonies and a lesser stimulating effect of interferon were shown.
Clinic of Haematology, Medical Academy Cracow, Poland.
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Zduńczyk
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Miszta
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Dabrowski
D000741:Anemia, Aplastic / Q000473:pathology*; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000166:cytology; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011994:Recombinant Proteins
D000961:Antilymphocyte Serum; D007370:Interferon Type I; D010835:Phytohemagglutinins; D011994:Recombinant Proteins