A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif.
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-determining gene, TDF.
Sinclair
A H
AH
Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
Berta
P
P
Palmer
M S
MS
Hawkins
J R
JR
Griffiths
B L
BL
Smith
M J
MJ
Foster
J W
JW
Frischauf
A M
AM
Lovell-Badge
R
R
Goodfellow
P N
PN
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D002874:Chromosome Mapping; D004247:DNA / Q000378:metabolism*; D015342:DNA Probes; D004268:DNA-Binding Proteins / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics; D006609:High Mobility Group Proteins / Q000235:genetics; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D009693:Nucleic Acid Hybridization; D011061:Poly A / Q000032:analysis; D011506:Proteins / Q000235:genetics*; D012313:RNA / Q000032:analysis; D012333:RNA, Messenger; D012568:Schizosaccharomyces / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid; D012729:Sex Chromosome Aberrations / Q000235:genetics; D012732:Sex Determination Analysis; D051876:Sex-Determining Region Y Protein; D013737:Testis / Q000032:analysis / Q000196:embryology / Q000378:metabolism; D014157:Transcription Factors; D014998:Y Chromosome
D015342:DNA Probes; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D006609:High Mobility Group Proteins; D009687:Nuclear Proteins; D011506:Proteins; D012333:RNA, Messenger; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors; D011061:Poly A; D012313:RNA; D004247:DNA