Serotonergic projections from the nodose ganglia to the nucleus tractus solitarius: an immunohistochemical and double labeling study in the rat.
Possible projections of serotonin (5-HT)-immunoreactive neurons in the nodose ganglia (NG) to the nucleus tractus solitarius (NTS) were investigated in the rat using a double labeling method combining retrograde transport and 5-HT immunohistochemistry. After injection of a complex of colloidal gold-apo-horseradish peroxidase into the medio-caudal and commissural parts of the NTS, most of the 5-HT-immunoreactive neurons were found to be labelled by the gold complex. The present study provides direct evidence for the existence, in the rat, of a serotonergic NG-NTS system. This system may be involved in the regulation of blood pressure and vigilance states.
INSERM U288, CHU Pitié-Salpêtrière, Paris, France.
A
A
Nosjean
C
C
Compoint
C
C
Buisseret-Delmas
H S
HS
Orer
N
N
Merahi
J J
JJ
Puizillout
R
R
Laguzzi
D000818:Animals; D001370:Axonal Transport; D006046:Gold; D006735:Horseradish Peroxidase; D007150:Immunohistochemistry; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology* / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D009620:Nodose Ganglion / Q000033:anatomy & histology* / Q000166:cytology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D014630:Vagus Nerve / Q000033:anatomy & histology*
D012701:Serotonin; D006046:Gold; D006735:Horseradish Peroxidase