[Effects of buspirone and buspirone-like 1-A-agonists of serotonin on the level of systemic blood pressure].
Experiments on anaesthetized rats showed that buspirone, its structural analogies (ipsapirone, campirone and levopirone) and active metabolite 1-(2-pyrimidinyl)-piperazine (0.1-30 mg/kg i.v.) produced bradycardia, hyperpnea and changed the arterial pressure level. Arterial pressure either increased or decreased that was determined by its initial level. The hypotension produced by all these drugs was of a central origin and mediated by hydroxytryptamine-1A-receptors. The pressor response resulted from activation of predominantly hydroxytryptamine-2-receptors of vascular smooth muscles.
Komissarov
I V
IV
Mamonov
A V
AV
Filippov
I T
IT
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002065:Buspirone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects
D014151:Anti-Anxiety Agents; D011985:Receptors, Serotonin; C037921:1-(2-pyrimidinyl)piperazine; D002065:Buspirone
Vliianie buspirona i buspironopodobnykh 1A-agonistov serotonina na uroven' sistemnogo arterial'nogo davleniia.