Adaptation to stress exposure prevents arrhythmogenic and contractural effects of the excess of Ca2+ on the heart by the increased activity of sarcoplasmic reticulum.
Adaptation of rats to repeated short-term stress exposure prevents, to a considerable extent, contractural and arrhythmogenic effects of high concentrations of extracellular Ca2+ on isolated heart. Increased efficiency of SR Ca2(+)-pump functioning and a significant increase in Ca2+ pump resistance to autolysis are proved to play the main role in this effect.
Institute of General Pathology and Pathological Physiology of the USSR AMS, Moscow.
F Z
FZ
Meerson
Malyshev IYu
T G
TG
Sazontova
D000818:Animals; D001143:Arousal / Q000502:physiology*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D002118:Calcium / Q000494:pharmacology*; D015220:Calcium Channels / Q000502:physiology*; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012519:Sarcoplasmic Reticulum / Q000502:physiology*
D015220:Calcium Channels; D002118:Calcium