Effect of mabuterol on tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs.
We studied the effect of mabuterol on the tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs. A catheter was inserted directly into the trachea through the mouth and 0.05 ml of saline solution with 30 mg of Fe3O4 was instilled into the trachea. After magnetization from outside the chest wall, the remanent magnetic field (RMF) strength generated in the trachea was sequentially measured with a flux-gate magnetometer. The decay of RMF immediately after sequential magnetization showed a clearance of Fe3O4 particles. Mabuterol (10 micrograms/kg) increased clearance as much as isoproterenol (10 micrograms/kg) 30 min after intravenous injection relative to control measurement (p less than 0.01). These results suggest that mabuterol is useful to promote clearance.
Division of Pulmonary Medicine, Kanto Rosai Hospital, Kawasaki, Japan.
M
M
Nakamura
M
M
Yamaya
T
T
Fukushima
K
K
Sekizawa
H
H
Sasaki
T
T
Takishima
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002976:Clenbuterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs; D005296:Ferrous Compounds; D007545:Isoproterenol / Q000494:pharmacology; D008280:Magnetics; D009079:Mucociliary Clearance / Q000187:drug effects*; D014132:Trachea / Q000187:drug effects / Q000502:physiology*
D000318:Adrenergic beta-Agonists; D005296:Ferrous Compounds; C034236:ferrous oxide; D007545:Isoproterenol; C044573:mabuterol; D002976:Clenbuterol