[Determination of the frequency of the A2m (2) allele of immunoglobin A in the Tunisian population by RFLP analysis].
The human IgA2 subclass has two allotypes A2m(1) and A2m (2). Using the RFLP technique, we determined the A2m(2) frequency in a sample of 29 tunisian individuals. In accordance with Lefranc and all. [6], the presence of a polymorphic EcoRI site of the A2m(2) allele was confirmed in our RFLP study whereas no BamHI nor HindIII polymorphisms were shown. Among the 29 cases studies, 11 were heterozygous A2m2-1, 17 homozygous A2m1-1 and 1 homozygous A2m2-2. The A2m2 allele frequency in the Tunisian population (0,22) is intermediate between the European frequency and the African one.
Laboratoire d'immunologie, Faculté de Médecine de Sfax, Tunisie.
F
F
Fakhfakh
S
S
Rouis
H
H
Makni
H
H
Ayadi
D011415:Complement Factor B / Q000235:genetics; D005787:Gene Frequency; D005803:Genes, Immunoglobulin; D006801:Humans; D007070:Immunoglobulin A / Q000235:genetics*; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014416:Tunisia / Q000208:ethnology
D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; D011415:Complement Factor B
Détermination de la fréquence de l'allèle A2M (2) des immunoglobulines A dans la population tunisienne par la technique de RFLP.