Effects of atipamezole and tetrahydroaminoacridine on nucleus basalis lesion-induced EEG changes.
In the present study the effect of combined anticholinesterase [tetrahydroaminoacridine (THA)] and alpha2-antagonist (antipamezole) treatment were evaluated on nucleus basalis (NB, quisqualic acid) lesion-induced EEG activity changes. THA (1, 3 and 6 mg/kg; an anticholinesterase) and atipamezole (Ati: 3 and 10 mg/kg; an alpha2-antagonist) suppressed dose-dependently NB lesion-induced high-voltage spindle activity and increase in slow/fast activity ratio. A combination of THA (3 mg/kg) and Ati (3 or 10 mg/kg) more effectively suppressed NB lesion-induced HVS activity than either of the drugs alone did. The present results suggest that alpha2-noradrenergic and NB cholinergic systems interact in the regulation of slow wave and HVS activity and that combined stimulation of these systems more effectively stabilize NB lesion-induced EEG changes.
Department of Neurology, University of Kuopio, Finland.
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P
Riekkinen
J
J
Sirviö
A
A
Valjakka
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M
Riekkinen
R
R
Lammintausta
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Riekkinen
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004338:Drug Combinations; D004569:Electroencephalography; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013377:Substantia Innominata / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D013619:Tacrine / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D004338:Drug Combinations; D007093:Imidazoles; C050701:atipamezole; D013619:Tacrine; D002795:Choline O-Acetyltransferase