[Fatal liver cell necrosis following administration of glafenine].
The case is described of a patient with fulminant hepatic failure attributed to intake of glafenine 400 mg daily for 15 days. The first symptoms appeared two weeks after discontinuation of glafenine. Other causes of hepatic necrosis could be excluded. Approximately five weeks after the onset of symptoms the patient died of hepatic failure. At autopsy massive hepatic necrosis and massive pancreatic necrosis were demonstrated.
Sint Antoniushove Ziekenhuis, Leidschendam.
G H
GH
Koek
B H
BH
Stricker
R W
RW
Veldhuizen
P
P
de Graaf
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005897:Glafenine / Q000009:adverse effects* / Q000627:therapeutic use; D006501:Hepatic Encephalopathy / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D009336:Necrosis / Q000139:chemically induced
D005897:Glafenine
Dodelijk verlopende levercelnecrose na gebruik van glafenine.