Attaching and effacing enteropathogenic Escherichia coli as a cause of infantile diarrhea in Bangkok.
To identify Escherichia coli that cause infantile diarrhea in Bangkok, Thailand, E. coli isolated in a year-long study of infantile diarrhea were examined for O and H serotypes and virulence determinants. Classic enteropathogenic E. coli (EPEC) were isolated from 28 of 509 infants with diarrhea (cases) and 11 of 509 age-matched controls (P = .009; odds ratio [OR], 2.64). Most of this difference was attributable to EPEC adherence factor (EAF)-positive EPEC that produced an attachment and effacement lesion, as identified in the fluorescence actin staining assay, isolated from 13 cases and 1 control (P = .003; OR, 13.3). EAF-EPEC was isolated from 15 cases and 10 controls (P = .418; OR, 1.52) and EAF+ non-EPEC from 17 cases and 10 controls (P = .242; OR, 1.72). EAF+EPEC that caused an attachment and effacement lesion was found in 3% of children less than 6 months old with diarrhea who were studied in an outpatient clinic in Bangkok in 1988.
Echeverria
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P
Armed Forces Research Institute of Medical Sciences; Children's Hospital, Bangkok, Thailand.
Orskov
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F
Orskov
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Knutton
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S
Scheutz
F
F
Brown
J E
JE
Lexomboon
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U
D018830:Adhesins, Escherichia coli; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis; D016022:Case-Control Studies; D004269:DNA, Bacterial / Q000032:analysis; D003968:Diarrhea, Infantile / Q000382:microbiology*; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012703:Serotyping; D013785:Thailand
D018830:Adhesins, Escherichia coli; D001425:Bacterial Outer Membrane Proteins; D004269:DNA, Bacterial