DNA ploidy pattern and S-phase characteristics of metastatic melanoma.
Samples of 130 metastatic melanomas from 92 patients were analyzed by DNA flow cytometry. DNA aneuploidy was observed in 67% of the patients. DNA indices were evenly distributed from 0.6 to 2.6 Tumors originating from primary lesions in the lower extremities were more frequently DNA aneuploid than those of other sites. S-phase fraction (SPF) was evaluable from 73 tumors. DNA aneuploid tumors had a significantly higher SPF than diploid tumors, and females had a higher SPF than males. Furthermore, distant metastases had a higher SPF than metastases in regional lymph nodes and in transit metastases, probably indicating a higher growth potential in metastases spreading to distant sites.
Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.
T
T
Muhonen
S
S
Pyrhönen
A
A
Laasonen
S
S
Asko-Seljavaara
K
K
Franssila
D000782:Aneuploidy; D004247:DNA / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics*; D009362:Neoplasm Metastasis; D011003:Ploidies; D016196:S Phase
D004247:DNA