[The anti-arrhythmia action of combinations of N-propylajmaline bromide with anti-arrhythmia agents of different classes].
In experiments on 68 dogs with ventricular arrhythmia at the late stage of experimental myocardial infarction caused by the coronary artery branch occlusion it was shown that combinations of N-propylaimaline bromide (IA class of antiarrhythmic agents) with trimecaine (IB class) or anapriline (II class) or phynoptine (IV class) induce a significant increase of the antiarrhythmic effect that is not observed at combination of N-propylaimaline with ethmosine (the both antiarrhythmic drugs belong to IA class). This potentiating effect is thought to be related to differences in the molecular mechanisms of action of antiarrhythmic drugs.
E I
EI
Gendenshteĭn
V P
VP
Balashov
Ia V
IaV
Kostin
V E
VE
Oleĭnikov
D000404:Ajmaline / Q000031:analogs & derivatives*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy / Q000209:etiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy; D011219:Prajmaline / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D000404:Ajmaline; D011219:Prajmaline
Protivoaritmicheskoe deĭstvie kombinatsiĭ N-propilaĭmalinbromida s protivoaritmicheskimi preparatami raznykh klassov.