Synergistic mechanisms in the adenosine- and neuropeptide-induced bronchoconstriction.
Neuropeptides and purines are possible neurotransmitters of the nonadrenergic noncholinergic nervous system of the airways. We investigated possible synergistic mechanisms between these two bronchoconstricting agents in a rat model. We observed that both adenosine and tachykinins enhance histamine release in the airways and that adenosine and neurokinin A act synergistically both on airway narrowing and histamine release.
Pauwels
R
R
Department of Respiratory Diseases, University Hospital, Ghent, Belgium.
Joos
G
G
Kips
J
J
Van Der Straeten
M
M
D000109:Acetylcholine / Q000494:pharmacology; D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D001992:Bronchoalveolar Lavage Fluid; D004357:Drug Synergism; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D015288:Neurokinin A / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology
D009479:Neuropeptides; D012701:Serotonin; D015288:Neurokinin A; D000241:Adenosine; D000109:Acetylcholine