[Relaxant effects of protopine on smooth muscles].
The relaxant effects of protopine (Pro) on smooth muscles were studied by recording isotonic contraction and radioimmunoassay. Pro relaxed the contraction of rabbit thoracic aorta, mesenteric artery, portal vein and guinea pig ileum and taenia colon induced by high K+ (70 mmol.L-1). Pro also inhibited the contraction of rabbit thoracic aorta, mesenteric artery, portal vein induced by NE (0.3 mumol.L-1) and guinea pig taenia colon induced by BaCl2 (1 mmol.L-1). Pro inhibited the intracellular Ca2+ release, but did not inhibit Ca2+ influx induced by NE. These results suggested that the smooth muscle relaxant mechanism of action of Pro may be the inhibition of intracellular Ca2+ release.
Huang
Y H
YH
Department of Pharmacology, Kunming Medical College, China.
Zhang
Z Z
ZZ
Jiang
J X
JX
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists; D007551:Isotonic Contraction / Q000187:drug effects*; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology
D000470:Alkaloids; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D006634:Histamine H1 Antagonists; D014700:Verapamil; D002118:Calcium; C009093:protopine