Resistance to vecuronium in patients with cerebral palsy.
To determine the electromyographic response of patients with cerebral palsy to vecuronium, 10 children (mean age, 6 yr 10 mo) without cerebral palsy and 11 children with cerebral palsy (mean age, 10 yr 3 mo) were studied. All patients were undergoing abdominal or orthopedic surgery and were anesthetized with isoflurane and nitrous oxide. The time from intravenous administration of 0.1 mg/kg of vecuronium to 25% recovery of control twitch height was 43.9 +/- 5.3 and 18.9 +/- 1.7 min (mean +/- SEM) in children without and with cerebral palsy, respectively (P less than 0.01). The authors conclude that patients with cerebral palsy are either resistant to vecuronium or have a rapid clearance as evidenced by the rapid recovery from neuromuscular blockade.
Department of Anesthesia, Riley Children's Hospital, Indiana University Medical Center, Indianapolis.
S S
SS
Moorthy
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G
Krishna
S F
SF
Dierdorf
D000771:Anesthesia, Intravenous; D001285:Atropine; D002547:Cerebral Palsy / Q000503:physiopathology*; D002648:Child; D004351:Drug Resistance; D004576:Electromyography; D006801:Humans; D009407:Nerve Block; D013874:Thiopental; D014673:Vecuronium Bromide / Q000494:pharmacology*
D001285:Atropine; D014673:Vecuronium Bromide; D013874:Thiopental