[Effects of vitamin E deficiency on bleomycin-induced pulmonary fibrosis in hamsters].
We examined the effect of free radicals on lung defense mechanism in bleomycin (BLM)-induced pulmonary fibrosis in hamsters. The concentration of vitamin E (VE) in the lung tissue increased significantly after intratracheal BLM administration. VE deficient hamsters showed increased lipid peroxide values in the lung tissue at a very early stage after BLM treatment. This was followed by decreased superoxide dismutase activities in the lung tissue. The results indicate that; 1) VE appears to be necessary for the prevention of lipid peroxidation in BLM-induced oxidant lung injury, 2) VE deficiency produces a large number of free radicals at the early stage after BLM treatment, and might induce protease-antiprotease imbalance within the lung, which probably causes an emphysematous change in the BLM-treated lung at a late stage after BLM administration.
Kato
S
S
First Department of Internal Medicine, Yamagata University School of Medicine.
Kudo
Y
Y
Takahashi
H
H
Osanai
K
K
Yakuwa
N
N
Nakamura
H
H
Sato
S
S
Takahashi
K
K
D000818:Animals; D001761:Bleomycin / Q000009:adverse effects*; D006224:Cricetinae; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D010100:Oxygen / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism; D014811:Vitamin E Deficiency / Q000150:complications* / Q000378:metabolism
D005609:Free Radicals; D008054:Lipid Peroxides; D001761:Bleomycin; D014810:Vitamin E; D013482:Superoxide Dismutase; D010100:Oxygen