On the rupture of an aneurysm.
The intracranial aneurysm, with an estimated occurrence of up to 4% in the general population, belongs among the most dangerous of cerebrovascular diseases. Although less than one-fifth of these cases results in a subarachnoid haemorrhage, the resulting disability and mortality rate is too high. More understanding is needed regarding aneurysm rupture and its deleterious effects. This study presents a physiologically-feasible explanation for the development of an enormous haemodynamic stress in the vicinity of the aneurysm in the cerebrovascular bed. Using a computer circulation model, this build-up of pressure was developed by sequentially imposing a series of interventions on the normal system.
Duros
J
J
Institute of Computing Techniques, Comenius University, Bratislava, Czechoslovakia.
Clark
M E
ME
Kufahl
R H
RH
Nadvornik
P
P
D003198:Computer Simulation; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications / Q000503:physiopathology*; D008954:Models, Biological; D012422:Rupture, Spontaneous; D013345:Subarachnoid Hemorrhage / Q000209:etiology*; D014636:Valsalva Maneuver / Q000502:physiology