The syntenic relationship between the critical deletion region for the Prader-Willi/Angelman syndromes and proximal mouse chromosome 7.
The deleted region of the proximal long arm of human chromosome 15, common to a large group of patients with the Prader-Willi and Angelman syndromes, has recently been defined. We have mapped to the mouse genome segments homologous to human probes found within and flanking this deletional region. These probes define a region of conserved synteny on proximal chromosome 7 of the mouse. Because the Prader-Willi and Angelman syndromes are postulated to result from genomic imprinting within the common deletion, these probes may define a genomically imprinted region on mouse chromosome 7.
Chaillet
J R
JR
Department of Genetics, Harvard Medical School, Boston, Massachusetts.
Knoll
J H
JH
Horsthemke
B
B
Lalande
M
M
D000818:Animals; D015139:Blotting, Southern; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002884:Chromosomes, Human, Pair 15; D003001:Cloning, Molecular; D015342:DNA Probes / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D009069:Movement Disorders / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011218:Prader-Willi Syndrome / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013577:Syndrome
D015342:DNA Probes