Synthesis and identification of a novel tetrazole metabolite of the angiotensin II receptor antagonist DuP 753.
Stearns
R A
RA
Department of Animal and Exploratory Drug Metabolism, Merck Sharp and Dohme Research Laboratories, Rahway, NJ 07065-0900.
Doss
G A
GA
Miller
R R
RR
Chiu
S H
SH
D000804:Angiotensin II / Q000037:antagonists & inhibitors*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000378:metabolism* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D005965:Glucuronates / Q000138:chemical synthesis / Q000378:metabolism / Q000493:pharmacokinetics; D000882:Haplorhini; D007093:Imidazoles / Q000378:metabolism* / Q000493:pharmacokinetics; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism; D019808:Losartan; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013056:Spectrophotometry, Ultraviolet; D013057:Spectrum Analysis; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000378:metabolism* / Q000493:pharmacokinetics
D057911:Angiotensin Receptor Antagonists; D001713:Biphenyl Compounds; D005965:Glucuronates; D007093:Imidazoles; D013777:Tetrazoles; D000804:Angiotensin II; D019808:Losartan