[Effects of interferon on immunoglobulin production in normal subjects and in patients with selective IgA deficiency. An "in vitro" study].
The ability of Interferon (IFN) alpha, beta and gamma to induce IgA production from IgA deficient patients lymphocytes was tested "in vitro". In affected patients IgG and IgM production was similar to the normal cases but no effect on IgA production was observed. In normal cases variable concentration of alpha- beta- and gamma-IFN resulted in different immunoglobulin production. In IgA selective deficiency a low number of SmIgA bearing cells and defective transformation in IgA-plasma cells was noted as possible primary defect.
Istituto di Patologia Medica dell'Università.
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Pozzato
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Perticarari
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Presani
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Luchesi
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Franzin
D000293:Adolescent; D000328:Adult; D004406:Dysgammaglobulinemia / Q000276:immunology*; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D008875:Middle Aged
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007370:Interferon Type I; D007371:Interferon-gamma; D007372:Interferons
Azione dell'interferone sulla produzione di immunoglobuline in soggetti normali e in pazienti affetti da deficit selettivo di IgA. Uno studio "in vitro".