Systematization of clinical management for recurrent aborters by combined immunological testing.
The natural outcomes of successive new pregnancies of 66 recurrent aborters were analysed in relation to their immunological profiles. The data demonstrated that the presence of anti-phospholipid antibodies (success rate 6.7%), positive anti-paternal cytotoxicity (8.7%) and a negative mixed lymphocyte reaction (MLR)-blocking effect (33.3%) in the patients' sera were factors associated with a poor prognosis. By the combined evaluation of these testings, a rational scheme of clinical management for recurrent aborters was established.
Department of Obstetrics and Gynecology, Niigata University School of Medicine, Japan.
I
I
Hasegawa
K
K
Takakuwa
K
K
Kanazawa
S
S
Takeuchi
D000026:Abortion, Habitual / Q000145:classification / Q000276:immunology* / Q000628:therapy; D001323:Autoantibodies / Q000032:analysis; D002985:Clinical Protocols / Q000592:standards*; D003601:Cytotoxicity Tests, Immunologic; D003663:Decision Trees; D005260:Female; D006801:Humans; D007159:Immunologic Tests / Q000379:methods*; D007959:Lymphocyte Culture Test, Mixed; D010743:Phospholipids / Q000276:immunology; D011247:Pregnancy; D011379:Prognosis
D001323:Autoantibodies; D010743:Phospholipids