Absence of polymorphism of sparteine oxidation in the South African Venda.
1 This study has found no occurrence of poor metabolism of sparteine within a South African Venda population of 97 subjects. 2 On the basis of MR (metabolic ratio) the mean and distribution of the results are very similar to those found in Ghanaians. 3 The distribution is also similar to that for fast metabolizers in Caucasians. 4 It is concluded that different P450 cytochromes are responsible for immediate oxidation of debrisoquine and sparteine, but that both may be activated by the same P450 reductase.
Sommers
D K
DK
Department of Pharmacology, University of Pretoria, South Africa.
Moncrieff
J
J
Avenant
J C
JC
D000328:Adult; D044383:Black People / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic / Q000235:genetics*; D013019:South Africa; D013034:Sparteine / Q000378:metabolism*
D013034:Sparteine