Early increase in histamine concentration in the islets of Langerhans isolated from rats made diabetic with streptozotocin.
Sprague-Dawley rats were separated in 4 groups. G1 received streptozotocin (ST). G2 received nicotinamide (NC) followed by ST. G3 was a NC control and G4 was a citrate control. The rats were sacrificed after 28 h and the islets isolated. Histamine and histaminase were determined. In the islets there was an increase in histamine content in G1 and a smaller increase in G2. The first two groups differ significantly and also in relation to the control groups. A decrease in islet histaminase does not seem responsible for the increased histamine, since group 2 (NC + ST) which had no diabetes, had a lower activity than group 1 (ST). It is suggested that histamine liberation by ST may be related to the diabetogenic effect of this drug.
Azevedo
M S
MS
Instituto de Química Fisiológica, Faculdade de Medicina, Lisboa, Portugal.
Silva
I J
IJ
Raposo
J F
JF
Neto
I F
IF
Falcão
J G
JG
Manso
C F
CF
D006631:Amine Oxidase (Copper-Containing) / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000097:blood / Q000378:metabolism*; D006636:Histamine Release; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D001786:Blood Glucose; D009536:Niacinamide; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing)