HIV-1 reproduction is inhibited by peptides derived frm the N- and C-termini of HIV-1 protease.
Two octapeptides derived from the sequence of the N- and C-termini of HIV-1 protease were tested for their ability to inhibit HIV-1 reproduction. Weak inhibitory activity was found with each of the two peptides. It is assumed that HIV-1 protease is the target of the inhibitory action. In spite of the moderate inhibitory activity the results are encouraging since they may be improved by various means.
Max-Planck-Institut für Biochemie, Martinsried bei München, Germany.
H J
HJ
Schramm
H
H
Nakashima
W
W
Schramm
H
H
Wakayama
N
N
Yamamoto
D000595:Amino Acid Sequence; D015496:CD4-Positive T-Lymphocytes / Q000382:microbiology; D016333:HIV Protease / Q000494:pharmacology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D009842:Oligopeptides; D016333:HIV Protease