[Electroconvulsive therapy and schizophrenia. Update from the data of the literature].
The place of electroconvulsive therapy (ECT) in the treatment of affective disorders is presently important and even inequaled in some depressive illness forms. But ECT is still controversial and its indications in the treatment of schizophrenia remain debated. In order to evaluate the place of this "vielle thérapeutique du futur" (39) in the treatment of schizophrenia, we reviewed the literature of the two last decades and tried to answer these questions. 1) Is ECT effectiveness in treatment of schizophrenic symptoms proved? 2) What is the effectiveness of ECT compared with other efficacious treatment? 3) Does the ECT + neuroleptic combination provide some advantage? and in which cases? The literature provides many studies in the topic. However, a considerable proportion of these studies make no use of modern methodological criteria. We only consider papers which: --give a clear diagnostic definition in patients groups and control groups, --use a standardized method of treatment, --use quantitative tools to evaluate results, --randomize treatment and use, when possible, double blind design. 1) Curative effects of ECT in schizophrenic symptoms: Brandon et al. (14) compare two groups of schizophrenic patients diagnosed according to PSE for schizophrenia and receiving equivalent doses of neuroleptics. The first group receives ECT when the other one receives simulate ECT. The former improved significantly better than the later. The difference persists but is no longer significant from the forth week of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Joober
R
R
S.H.U. de Santé Mentale et de Thérapeutique, Hôpital Sainte-Anne, Paris.
Bennegadi
Z
Z
Olié
J P
JP
Lôo
H
H
D014150:Antipsychotic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004565:Electroconvulsive Therapy; D006801:Humans; D012008:Recurrence; D012559:Schizophrenia / Q000628:therapy*
D014150:Antipsychotic Agents
Electroconvulsivothérapie et schizophrénie. Mise au point à partir des données de la littérature.