[Contents of natural antibodies to thrombin and alpha-2-macroglobulins in the blood of donors and patients with ischemic heart disease].
Natural IgG and IgM antibodies to thrombin and alpha 2-macroglobulin were measured in donor and coronary patients' plasma by enzyme immunoassay. The patients were divided into 3 groups with various types of changes in antibody levels. Increased level of antithrombin antibodies appears to be related to additional production of antibodies in response to elevation of thrombin concentration in the blood stream or to shift of the synchronous process between free antibodies and thrombin, bound in immune complexes. Further studies will clarify the mechanism of these processes.
Miagkova
M A
MA
Polevaia
O Iu
OIu
Novozhenova
T V
TV
Lekokhmakher
S S
SS
Borzova
L V
LV
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D001782:Blood Donors; D003327:Coronary Disease / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008875:Middle Aged; D013917:Thrombin / Q000276:immunology*; D000511:alpha-Macroglobulins / Q000276:immunology*
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000511:alpha-Macroglobulins; D013917:Thrombin
Soderzhanie estestvennykh antitel k trombinu i alfa2-makroglobulinu v plazme donorov i bol'nykh ishemicheskoĭ bolezn'iu serdtsa.