[Biological activity of kurilostatin--an unusual alkaloid from sea sponges].
Biological activity of kurilostatin (KS), an unusual alkaloid from the sea sponge was studied. KS was shown to exert a strong cytostatic effect upon tumor cells and activated lymphocytes by mitogen. However it does not display any antitumoral activity in vivo. KS was found to induce release of free [Ca2+] from the above mentioned cells. This process is probably the basis of the cytostatic effect mechanism of KS.
A M
AM
Popov
T N
TN
Makar'eva
V A
VA
Stonik
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D008214:Lymphocytes / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000970:Antineoplastic Agents; D008081:Liposomes; C073591:kurilostatin; D002118:Calcium
Biologicheskaia aktivnost' kurilostatina--neobychnogo alkaloida iz morskikh gubok.