Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y.
Minor histocompatibility (H) antigens can be peptides derived from cellular proteins that are presented on the cell surface by major histocompatibility complex (MHC) class I molecules. This is similar to viral antigens, because in both cases cytotoxic T lymphocytes (CTLs) recognize artificially produced peptides loaded on target cells. Naturally processed minor H peptides were found to be similar to those artificial CTL-epitopes, as far as size and hydrophobicity is concerned. The peptides studied were isolated from a transfectant that expressed a model CTL-defined antigen, beta-galactosidase, from male cells that express H-Y, which has been known operationally since 1955, and from cells that express H-4, known since 1961.
Rötzschke
O
O
Max-Planck-Institut für Biologie, Abteilung Immungenetik, Tübingen, Federal Republic of Germany.
Falk
K
K
Wallny
H J
HJ
Faath
S
S
Rammensee
H G
HG
D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000302:isolation & purification; D005260:Female; D006182:H-Y Antigen / Q000032:analysis* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015778:Minor Histocompatibility Antigens / Q000032:analysis* / Q000276:immunology; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes; D006182:H-Y Antigen; D015778:Minor Histocompatibility Antigens; D010455:Peptides