Islet cell tumor.
A case of islet cell tumor occurring in a patient with the multiple endocrine neoplasia type I syndrome is reported. Immunostaining for insulin was strongly positive in the tumor cells. Numerous dense-core granules of endocrine caliber were identified ultrastructurally. Morphometric analysis of the secretory granules in 20 islet cell tumors gave a granule size of 182 +/- 52 nm (mean +/- standard deviation).
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston 77030.
B
B
Fitzpatrick
N G
NG
Ordoñez
B
B
Mackay
D007516:Adenoma, Islet Cell / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D000328:Adult; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005260:Female; D005934:Glucagon / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000032:analysis; D008854:Microscopy, Electron; D009377:Multiple Endocrine Neoplasia / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D010191:Pancreatic Polypeptide / Q000032:analysis
D007328:Insulin; D010191:Pancreatic Polypeptide; D005934:Glucagon