The evolution of hormonal signalling systems.
1. A comparative analysis was made of chemosignalling systems responsible for the action of hormones, hormone-like substances, pheromones, etc. in vertebrates--multicellular invertebrates--unicellular eukaryotes. Many common features revealed in structural-functional organization of the above systems give evidence of their evolutionary conservatism. 2. It was shown that some molecular components as well as signal transduction mechanisms similar to those of higher eukaryote hormonal signalling systems are present in such early organisms as bacteria. This allowed a suggestion that the roots of chemosignalling systems are likely to be found in prokaryotes. 3. The evolution of hormonal signalling systems is discussed in terms of current theories of the origin of eukaryotic cell, its organelles and components. A hypothesis is put forward about endosymbiotic genesis of these signal transduction systems in eukaryotes. 4. A possible evolutionary scenario of the formation of hormonocompetent systems is proposed with hormone-sensitive adenylate cyclase complex taken as an example.
Pertseva
M
M
Laboratory of Evolution of Biochemical Communication Systems, Sechenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences U.S.S.R., Leningrad.
D000818:Animals; D005075:Biological Evolution; D005057:Eukaryotic Cells / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D007448:Invertebrates / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D014714:Vertebrates / Q000502:physiology
D006728:Hormones; D011956:Receptors, Cell Surface