[Value of amniotic gamma-glutamyl-transpeptidase assay in the diagnosis of fetal digestive stenosis after 24 weeks of amenorrhea].
In 18 women compared with 1,181 controls, foetal digestive tract stenoses were discriminated, independently of the gestational age, by a more than 50 IU/l level of gamma-glutamyl transpeptidase in the amniotic fluid. This test had a specificity of 99% and a sensitivity of 85% which was accounted for by the inclusion in the study of distal stenoses and oesophageal atresias, all conditions where the gamma-glutamyl transpeptidase level is normal. In cases with ultrasonically detected abdominal wall abnormalities, this test is also useful in the diagnosis of subjacent digestive tract stenosis.
Houze de l'Aulnoit
D
D
Département de Gynécologie-Obstétrique, Faculté Libre de Médecine de Lille, Hôpital Saint-Philibert, Lomme.
Forzy
G
G
Dhondt
J L
JL
Brabant
G
G
Ellart
D
D
Delcroix
M
M
Farriaux
J P
JP
D000653:Amniotic Fluid / Q000737:chemistry*; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000453:epidemiology; D004065:Digestive System Abnormalities; D005069:Evaluation Studies as Topic; D005315:Fetal Diseases / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D011296:Prenatal Diagnosis / Q000379:methods / Q000592:standards*; D015995:Prevalence; D012680:Sensitivity and Specificity; D005723:gamma-Glutamyltransferase / Q000737:chemistry*
D005723:gamma-Glutamyltransferase
Intérêt du dosage de la gamma-glutamyl-transpeptidase amniotique dans le diagnostic des sténoses digestives foetales après 24 semaines d'aménorrhée.