Human immunodeficiency virus type 1 antigenaemia is enhanced in patients with disseminated cytomegalovirus infection and deficient T lymphocytes.
We have studied 61 patients with the acquired immunodeficiency syndrome (AIDS) regarding the relationships between disseminated cytomegalovirus (CMV) infection with CMV retinitis, HIV1 antigenaemia and CD4+ and CD8+ T-cell deficiency. HIV1 p24 antigenaemia was present in all patients with CMV retinitis (at a high concentration), but in only 28% of patients without retinitis (at a low concentration). Compared to patients without retinitis, those patients who developed retinitis had lower CD4+ and CD8+ prior to and during AIDS. CMV may contribute to deficiencies of T lymphocytes in patients with AIDS.
Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA 92270.
M
M
Fiala
L A
LA
Cone
R
R
Christopher
V
V
Kermani
J A
JA
Gornbein
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000150:complications / Q000276:immunology*; D015828:Eye Infections, Viral / Q000150:complications / Q000276:immunology; D016655:HIV Core Protein p24 / Q000097:blood*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D012173:Retinitis / Q000150:complications / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014766:Viremia / Q000276:immunology
D016655:HIV Core Protein p24