Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum.
6-Hydroxydopamine (6-OHDA) was injected into the rat striatum unilaterally. After 2-4 weeks, a marked decrease in the number of tyrosine hydroxylase-immunoreactive neuronal perikarya and dendrites was observed in the substantia nigra (SN) ipsilateral to the injection. Nissl staining showed a severe cell loss in the same region and electron microscopy revealed neuronal perikarya under degenerating process in the SN. The results showed a retrograde cytotoxic effect of 6-OHDA from the striatal terminals to their dopaminergic neuronal perikarya in the SN, and suggest the possibility that the striatum may be a primary locus in the degeneration process in Parkinson's disease.
Department of Anatomy, Kyoto Prefectural University of Medicine, Japan.
Y
Y
Ichitani
H
H
Okamura
Y
Y
Matsumoto
I
I
Nagatsu
Y
Y
Ibata
D000818:Animals; D003342:Corpus Striatum; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007150:Immunohistochemistry; D007267:Injections; D008297:Male; D008854:Microscopy, Electron; D009410:Nerve Degeneration / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000166:cytology*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology
D006892:Hydroxydopamines; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase