Bidirectional potentiation between D1 and D2 dopamine agonists: effects of unilateral intra-accumbens injections on locomotor activity in mice.
We tested the effect of a single unilateral injection of a specific D1 agonist into the nucleus accumbens on the behavioral response to a subsequent unilateral intra-accumbens injection of a selective D2 agonist ten days later. The effect of the inverse order of presentation (D2 agonist followed ten days later by a D1 agonist) was also tested. No significant differences between the locomotor effects of the intra-accumbens injection of either SKF-38393 (3.5 micrograms) or LY-171555 (10 micrograms) were observed during the first test. Ten days later, during the second test, intra-accumbens injection of either the LY-171555 and SKF-38393 increased the percentage of contralateral rotations relative to the first test while LY-171555 also increased the total number of rotations. Control injections showed that these effects of LY-171555 and SKF-38393 were not due to a conditioning process. Rather, the results suggested that the locomotor changes observed during the second test were the result of behavioral sensitization due to the initial acute injection of the agonists.
Laboratoire de Neurosciences Comportementales et Cognitives, URA CNRS n.339, Université de Bordeaux I, Talence, France.
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Messier
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Mrabet
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Durkin
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Destrade
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004873:Ergolines / Q000494:pharmacology*; D007267:Injections; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects*; D019257:Quinpirole
D015259:Dopamine Agents; D004873:Ergolines; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine