Expression of ret proto-oncogene in human neuroblastomas.
We examined the expression of ret proto-oncogene (proto-ret) in surgically resected human neuroblastomas. Slot blot RNA hybridization revealed that all 29 neuroblastomas examined expressed the proto-ret, the relative intensity of the hybridization ranging from 1 to 48. No correlation was found between the level of expression of proto-ret and the clinical stage. The level of expression was also not correlated with N-myc amplification, the patient's age or the histological type of the tumor. Based on the previous finding that proto-ret expression is very rarely detected in tumor cell lines other than those of neuroblastoma, proto-ret expression was suggested to be a characteristic of neuroblastomas, and possibly to be involved in the genesis of neuroblastomas.
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo.
M
M
Nagao
Y
Y
Ishizaka
A
A
Nakagawara
K
K
Kohno
M
M
Kuwano
T
T
Tahira
F
F
Itoh
I
I
Ikeda
T
T
Sugimura
D000199:Actins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes / Q000235:genetics*; D012313:RNA / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D000199:Actins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D012313:RNA