Survey of 34 pregnant women with hepatitis A and their neonates.
Thirty-four pregnant women with hepatitis A and their neonates were investigated on serum anti-HAV IgM, ALT (GPT) and clinical manifestations (with 34 randomized controls) during the outbreak of viral hepatitis A in Shanghai. The result showed no evidence of maternal-infant transmission of hepatitis A, and no birth defect was found. Sufficient rest and proper diet for and close surveillance of the pregnant woman were suggested to ensure the well-being of mother and child. In addition, we found immune gamma-globulin given to the neonates born of mothers with hepatitis A may be beneficial to avoid horizontal transmission of hepatitis A.
Zhang
R L
RL
Department of Pediatrics, Shanghai Second Medical University.
Zeng
J S
JS
Zhang
H Z
HZ
D000328:Adult; D005260:Female; D006506:Hepatitis A / Q000517:prevention & control / Q000635:transmission*; D006508:Hepatitis Antibodies / Q000032:analysis*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D005719:gamma-Globulins / Q000008:administration & dosage
D006508:Hepatitis Antibodies; D007075:Immunoglobulin M; D005719:gamma-Globulins