Acyclovir resistant genital herpes virus infection in a patient with AIDS.
Three acyclovir resistant strains of HSV-2 were isolated from mucoulcerative lesions in a patient suffering from AIDS in whom the oral and intravenous acyclovir treatment was unsuccessful. All the isolates were classified by monoclonal antibodies and showed no differences in DNA restriction patterns.
Department of Virology, Institute of Tropical Medicine, Pedro Kouri, Havana City, Cuba.
M
M
Marrero
M
M
Alvarez
J C
JC
Millan
P
P
Mas Lago
M
M
Soler
M
M
Diaz
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000212:Acyclovir / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000284:Administration, Oral; D000328:Adult; D000818:Animals; D004352:Drug Resistance, Microbial; D006558:Herpes Genitalis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D018139:Simplexvirus / Q000187:drug effects* / Q000302:isolation & purification; D014709:Vero Cells
D000212:Acyclovir