[Respiratory effects of microinjection of three kinds of neurotransmitters in ventromedial region of nucleus facialis].
The effects of microinjection of three kinds of neurotransmitters in ventromedial region of nucleus facialis (VMNF) on respiration were observed in vagotomized, spontaneously breathing rabbits anesthetized with urethane. Microinjection of adrenaline in VMNF induced a marked increase in respiratory rate and amplitude of integrated phrenic activity associated with an increase in the initial rate of rise of inspiratory activity. However, alpha-receptor antagonist tolazoline elicited marked decreases in respiratory rate accompanied by little or no changes in amplitude of integrated phrenic activity and initial rate of rise of inspiratory activity. The respiratory effects of microinjection of adrenaline were blocked by previous injection of tolazoline. Microinjection of GABA and glycine resulted in a decrease of respiratory frequency. These results suggest that adrenaline, GABA and glycine may modulate respiration by acting on VMNF neurons as neurotransmitters.
Zhang
Y Q
YQ
Department of Physiology, Shandong Medical University, Jinan.
Man
H Y
HY
Liu
L
L
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D008845:Microinjections; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D011149:Pons / Q000502:physiology; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*; D014043:Tolazoline / Q000494:pharmacology; D014697:Ventromedial Hypothalamic Nucleus; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018377:Neurotransmitter Agents; D005680:gamma-Aminobutyric Acid; D014043:Tolazoline; D005998:Glycine; D004837:Epinephrine