A myelin basic protein antibody cascade in purified IgG from cerebrospinal fluid of multiple sclerosis patients.
Immunoglobulin G (IgG) was purified by affinity chromatography from the CSF of multiple sclerosis (MS) patients and controls. In MS patients, the IgG fraction contains anti-myelin basic protein (anti-MBP), anti-MBP neutralizing antibody and an antibody which inhibits neutralization of anti-MBP. Anti-MBP was detected in patients with acute relapses, anti-MBP neutralizing antibody was present in patients in clinical remission and the inhibiting antibody was detected in patients with chronically progressing MS. A myelin basic protein antibody cascade could be involved in the mechanism of MS.
Department of Medicine (Neurology), University of Alberta, Edmonton, Canada.
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D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D006801:Humans; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology*
D001323:Autoantibodies; D004676:Myelin Basic Protein