Alterations of T helper/inducer and T suppressor/inducer cells in patients with recurrent aphthous ulcers.
The peripheral blood lymphocytes of patients with recurrent aphthous ulcers (RAU) were studied during various stages of their disease by two-color immunofluorescence with the use of monoclonal antibodies directed against human T cells (CD3), T helper cells (CD4), T suppressor cells (CD8), T helper/inducer cells (CDw29), and T suppressor/inducer cells (CD45R). All patients with severe RAU showed increased numbers of T helper/inducer cells (CDw29) and decreased numbers of T suppressor/inducer cells (CD45R). One of six patients with RAU showed a decreased T helper/T suppressor ratio (CD4/CD8). These findings suggest that patients with RAU may possess primary immunologic abnormalities.
Department of Oral Surgery and Microbiology, University of Rochester, School of Medicine and Dentistry, N.Y.
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R
Landesberg
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Fallon
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Insel
D000328:Adult; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D000943:Antigens, Differentiation / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D017252:CD3 Complex; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D019012:Integrin beta1; D017493:Leukocyte Common Antigens; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000032:analysis; D013281:Stomatitis, Aphthous / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D019012:Integrin beta1; D011948:Receptors, Antigen, T-Cell; D017493:Leukocyte Common Antigens