Thermal inactivation of different measles virus strains.
The kinetics of thermal inactivation at 45 degrees C was investigated with different measles virus strains. The decrease of virus infectivity was determined by plaque counting test. The inactivation velocity of strains Schwarz, Moraten, Woodfalk, L16/SSW, L16/Moscow, and L16/S3 based on regression curve analysis (virus titres by time) allowed to divide them into 3 categories according to temperature sensitivity. Our results showed that development of a thermostable measles vaccine does not require selection of a thermoresistant virus variant if certain conditions for virus harvest are fulfilled.
Institute of Virology and Epidemiology, Berlin, Germany.
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Klamm
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Pollex
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Henning
D006358:Hot Temperature; D008458:Measles Vaccine; D008459:Measles virus / Q000254:growth & development* / Q000276:immunology; D015164:Vaccines, Inactivated; D010948:Viral Plaque Assay; D014775:Virus Activation
D008458:Measles Vaccine; D015164:Vaccines, Inactivated