The Monoclonal Antibody Program of the Cuban Institute of Oncology and Radiobiology.
A Monoclonal Antibody Program was launched at the National Institute of Oncology and Radiobiology (INOR) in Cuba in 1985. Eleven MAbs have been obtained which recognize different leukocyte antigens. Four MAbs a series of reagents raised against different types of cytokeratins, carcino-embryonic antigen and the membrane receptor for Epidermal Growth Factor. These MAbs are especially useful in immunohistochemistry for the study of human tumours, leukemias and lymphomas. Three ultramicro-ELISA systems have being deviced using MAbs. First trials are being made with radioactive MAbs for immunoscintigraphy. The use of anti T-cell MAbs for the prevention of rejection crisis in patients receiving organ transplantation and for the treatment of patient with cutaneous T-cell lymphoma is still mostly a matter for research.
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Cuban Institute of Oncology and Radiobiology.
D000047:Academies and Institutes; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003462:Cuba; D004797:Enzyme-Linked Immunosorbent Assay; D004815:Epidermal Growth Factor / Q000032:analysis; D006801:Humans; D007118:Immunoassay; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007962:Leukocytes / Q000276:immunology; D008495:Medical Oncology; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy; D011853:Radiobiology; D012106:Research
D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D007136:Immunoglobulins; D004815:Epidermal Growth Factor; D007633:Keratins