Anorexia following the intrahypothalamic administration of amylin.
The intrahypothalamic injection of rat amylin reduced feeding in schedule-fed rats for eight hours. Specificity of this anorectic response was indicated by an appropriate dose-response relationship and the absence of effect of human amylin. Amylin-induced anorexia was accompanied by alterations in neurotransmitter metabolism similar to those observed in anorectic tumor-bearing rats. These results indicate that amylin may inhibit feeding by acting directly on hypothalamic neurons to alter metabolism of neurotransmitter systems known to affect feeding behavior.
Chance
W T
WT
Department of Surgery, University of Cincinnati Medical Center, OH 45267.
Balasubramaniam
A
A
Zhang
F S
FS
Wimalawansa
S J
SJ
Fischer
J E
JE
D000682:Amyloid / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants; D001923:Brain Chemistry / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D006801:Humans; D007031:Hypothalamus; D007267:Injections; D058228:Islet Amyloid Polypeptide; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000682:Amyloid; D001067:Appetite Depressants; D058228:Islet Amyloid Polypeptide; D018377:Neurotransmitter Agents; D015740:Calcitonin Gene-Related Peptide