Nitrogen retention caused by growth hormone in patients undergoing gastrointestinal surgery with epidural analgesia and parenteral nutrition.
Nineteen patients undergoing elective gastrointestinal surgery were randomised to receive recombination human growth hormone (n = 9) or placebo (n = 10) for the first five postoperative days. All received epidural analgesia and total parenteral nutrition during the same period (energy supply 125% of basal metabolic rate, mean nitrogen (+/- SEM) 5.7 (+/- 0.1) g/m2). Nitrogen and potassium retention was induced in the growth hormone group compared with the placebo group (cumulative nitrogen balance 4.1 (+/- 1.1) g/m2 in the growth hormone group and -3.1 (+/- 1.8) g/m2 in the placebo group, p less than 0.01; cumulative potassium balance 80.8 (+/- 4.7) mmol/m2 in the growth hormone group and 43.1 (+/- 11.4) mmol/m2 in the placebo group, p less than 0.01). In the growth hormone group, serum glucose concentrations increased each evening and mean serum albumin concentrations were reduced throughout the period; the morning pulse rates were decreased, and the patients gained weight compared with the placebo group.
Department of Surgery, Tromsø University Hospital, Norway.
M
M
Mjaaland
K
K
Unneberg
R
R
Hotvedt
A
A
Revhaug
D000328:Adult; D000368:Aged; D015360:Analgesia, Epidural; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D013505:Digestive System Surgical Procedures; D004311:Double-Blind Method; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010288:Parenteral Nutrition; D010919:Placebos; D011994:Recombinant Proteins
D001786:Blood Glucose; D006454:Hemoglobins; D010919:Placebos; D011994:Recombinant Proteins; D013006:Growth Hormone; D002097:C-Reactive Protein; D009584:Nitrogen