[The cytokeratin skeleton of the human organ of Corti and its functional significance].
In the adult human organ of Corti cytokeratin (CK) is expressed by all supporting cells enclosing it like a shell. The pattern of immunoreactivity clearly demonstrates a quantitative gradient in the expression of CK, with more CK at the apex than at the base of the cochlea. Predominantly in the apical cochlear turns, the CK-shell separates the compartment of the inner hair cells from that of the outer hair cells. Ultrastructurally, the supporting cells contain a loose fibrillary network which apically is oriented toward the desmosome chain and which can be clearly distinguished from the well-known tubular filaments (microtubuli). Some supporting cells show centrioles. Both the expression of CK and the presence of centrioles indicate a possible potential for cell regeneration. Ultrastructurally, outer hair cells and Deiters' cells show features of a specialized contact zone which might be of functional significance regarding the contractile abilities of the outer hair cells. In the human organ of Corti, vimentin is expressed only by the inner and outer pillar cells. These cells thus express CK together with vimentin. The distinct shell configuration of the CK network in the organ of Corti gives it a tonotopically related difference in rigidity which not only must be of importance for cochlear perception of sound but also could explain the reduced vulnerability of the ear to low frequencies.
Klinik für Hals-Nasen-Ohren-Krankheiten, Hals- und Gesichtschirurgie, Kantonsspital Luzern, Schweiz.
W
W
Arnold
M
M
Anniko
D003599:Cytoskeleton / Q000648:ultrastructure*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000502:physiology*; D008854:Microscopy, Electron; D009925:Organ of Corti / Q000033:anatomy & histology*; D014746:Vimentin / Q000502:physiology
D014746:Vimentin; D007633:Keratins
Das Zytokeratinskelett des menschlichen Corti-Organs und seine funktionelle Bedeutung.