Hemoglobin oxygen dissociation (P50) in bronchopulmonary dysplasia.
A study was devised to determine the P50 in infants with bronchopulmonary dysplasia (BPD). Other factors such as red blood cell 2,3-diphosphoglycerate (2,3-DPG) level proportions of adult (HbA) to fetal (HbF) hemoglobins which could affect P50 were also measured. Fourteen infants with clinical and radiological signs of BPD with a mean post-conceptional age of 42.2 +/- 4.7 weeks born at a mean gestational age of 29.3 +/- 2.0 weeks were evaluated. The percentage of HbF determined in 8 infants was 40.1 +/- 20.3% and the mean 2,3-DPG concentrations was 13.1 +/- 2.2 mumol/g Hb. The P50 was 25.1 +/- 2.7 mm Hg (range 18-29.5 mm Hg). When a HbO2 curve was established based on a large volume of blood consisting of adult blood and newborn cord blood mixed to attain a P50 of 25.1 mm Hg, the PaO2 at 90% O2 saturation was 52 mm Hg. Since there can be a wide range in HbO2 in infants with chronic BPD, pulse oximetry remains the most prudent method of monitoring oxygen therapy in BPD infants.
Furfaro
S
S
Sainte-Justine Hospital, Department of Pediatrics, University of Montreal, Canada.
Prosmanne
J
J
Bard
H
H
D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D004163:Diphosphoglyceric Acids / Q000032:analysis; D005319:Fetal Hemoglobin / Q000032:analysis; D006441:Hemoglobin A / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010092:Oximetry; D010100:Oxygen / Q000097:blood*
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D006441:Hemoglobin A; D005319:Fetal Hemoglobin; D010100:Oxygen