Role of calmodulin/protein kinase C in interferon production by poly(rI).poly(rC) in primed human cell cultures.
Human cells treated with trifluoperazine (TFP) or K252a prior to and/or during priming with human interferon-alpha (HuIFN-alpha) produce significantly more IFN on induction with poly(rI).poly(rC) than primed cells in the absence of the drug. Results suggest that calmodulin/protein kinase activity may be involved in priming activity of HuIFN-alpha.
Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo 14214.
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D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000502:physiology*; D002227:Carbazoles / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D026121:Indole Alkaloids; D007370:Interferon Type I / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis*; D011070:Poly I-C / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000502:physiology*; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D002227:Carbazoles; D026121:Indole Alkaloids; D007370:Interferon Type I; D014268:Trifluoperazine; D007372:Interferons; C049985:staurosporine aglycone; D011493:Protein Kinase C; D011070:Poly I-C