Crystals in an oligodendroglioma: an optical, histochemical, and ultrastructural study.
The report describes an oligodendroglioma that was examined in four biopsies and contained a large number of intracytoplasmic crystals. The crystals appeared in neoplastic cells with eosinophilic cytoplasms and eccentric nuclei. They were positive to periodic acid-Schiff stain and resistant to diastase. A lysosomal genesis of the crystals is proposed on the basis of a transition observed between lysosomal bodies with lipid droplets and those with crystalloid electron-dense structures. The morphologic and histochemical features of these crystals are compared to those in other tumors, lesions, and nonneoplastic cells.
Department of Pathology, Fundacion Jimenez Diaz, Madrid, Spain.
J L
JL
Sarasa
S
S
Ramon y Cajal Agüeras
J
J
Burzaco
D000328:Adult; D010131:Aminosalicylic Acid; D000681:Amylases; D001932:Brain Neoplasms / Q000032:analysis* / Q000648:ultrastructure; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003460:Crystallization; D003593:Cytoplasm / Q000032:analysis / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D008062:Lipofuscin / Q000032:analysis; D008247:Lysosomes / Q000032:analysis / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009837:Oligodendroglioma / Q000032:analysis* / Q000648:ultrastructure; D010503:Periodic Acid-Schiff Reaction; D013194:Staining and Labeling
D008062:Lipofuscin; D010131:Aminosalicylic Acid; D000681:Amylases