Detection of P-glycoprotein in human urogenital carcinomas and its relationship to epidermal growth factor receptor expression.
P-glycoprotein and epidermal growth factor (EGF) receptor expression were surveyed immunohistochemically in the tissue of urogenital carcinomas including 12 renal cell carcinomas, 9 bladder transitional cell carcinomas, 2 prostate adenocarcinomas and 1 penile squamous cell carcinoma. Three bladder carcinomas and the penile carcinoma were following initial chemotherapy at the time of relapse. P-glycoprotein expression was detected in 3 of 12 renal cell carcinomas and in all recurrent carcinomas. EGF receptor was not detected in any of the specimens.
Department of Urology, Saitama Medical School, Moroyama, Japan.
Y
Y
Kageyama
M
M
Katoh
K
K
Okada
K
K
Yoshida
T
T
Tsuruo
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000368:Aged; D000369:Aged, 80 and over; D066246:ErbB Receptors / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000737:chemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D010412:Penile Neoplasms / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000737:chemistry; D001749:Urinary Bladder Neoplasms / Q000737:chemistry; D014565:Urogenital Neoplasms / Q000737:chemistry*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D066246:ErbB Receptors