Attenuation of hippocampal inhibition by a NMDA (N-methyl-D-aspartate) receptor antagonist.
The effects of the competitive NMDA (N-methyl-D-aspartate) receptor antagonist, APV (2-amino-5-phosphonopentanoate; AP5), were examined in the hippocampal slice preparation. APV (50-100 microM) attenuated inhibition of the orthodromically evoked population spikes in the CA1 region produced by a conditioning stimulus to the alveus or to the stratum radiatum. This suggests that NMDA receptors contribute to synaptic activation of the inhibitory interneurons by a single afferent volley.
Department of Pharmacology and Therapeutics, McGill University, Montreal, Que., Canada.
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Capek
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Esplin
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate; D008274:Magnesium