[CEA, GICA, TPA, fibrinopeptide-A, gamma-GT and gastric cancer. A contribution to the rationalization of a combined assay].
CEA, GICA, TPA, Fibrinopeptide-A (FpA) and Gamma-GT serum levels were evaluated in 312 patients affected by gastric cancer, to assess their effectiveness in diagnosis, evaluation of disease extension and follow-up of gastric cancer. In 204 patients neoplasia was limited to the stomach, in 108 liver metastases, ascertained by ultrasonography and/or TAC, were present. CEA was increased in 224 cases (71.8%); mean values were significantly higher in metastatic patients than in metastasis-free group (p less than 0.001), but overlap of values between the two groups was observed in about one third of cases. GICA was increased in 268 patients (86%) and TPA in 306 (98%), without significant differences between metastatic and metastasis-free group. FpA was increased in all patients; when metastases were present it was significantly higher than in metastasis-free patients (p less than 0.001), with negligible overlap of values between the two groups. Gamma-GT was normal in 202 metastasis-free patients (99%) and increased in 105 patients with liver metastases (97%). On the basis of these data CEA does not seem to have striking diagnostic sensibility nor reliability in differentiating presence from absence of liver metastases in patients with gastric cancer. Combined assay of TPA, FpA and Gamma-GT seems to be the most reliable serological approach in diagnosis, staging and follow-up of gastric cancer.
Istituto di Patologia medica, Università, Ferrara.
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Abbasciano
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Graziano
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Arcudi
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Tassinari
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Nielsen
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Sartori
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005260:Female; D005344:Fibrinopeptide A / Q000032:analysis*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000032:analysis*; D011863:Radioimmunoassay; D013274:Stomach Neoplasms / Q000175:diagnosis*; D019396:Tissue Polypeptide Antigen; D005723:gamma-Glutamyltransferase / Q000097:blood*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D010455:Peptides; D019396:Tissue Polypeptide Antigen; C031192:oncofetal antigens; D005344:Fibrinopeptide A; D005723:gamma-Glutamyltransferase
CEA, GICA, TPA, fibrinopeptide-A, gamma-GT e cancro gastrico. Un contributo alla razionalizzazione di un dosaggio combinato.