[Immune modulating effect of isoprinosine in patients with post-alcoholic liver cirrhosis].
Immunomodulating effect of isoprinosine was estimated in group of 10 patients with postalcoholic liver cirrhosis and compared with another group of 10 patients with postinflammatory liver cirrhosis with infection of hepatitis B virus. Disturbances of immunologic reactivity in the patients with postalcoholic liver cirrhosis mainly concerned increased immunoglobulin G, A concentrations in the blood serum, decreased percentage values of lymphocytes T and their subpopulations (lymphocytes T4 and T8) and increased percentage of lymphocytes B. Disturbances of the examined indices of the immunologic reactivity in the group of patient with postinflammatory liver cirrhosis concerned increased concentrations of circulating immunologic complexes, immunoglobulins A and M in the blood serum and decreased percentage of lymphocytes T and their subpopulation. Treatment with isoprinosine resulted in different immunologic effect in the examined patients concerning mainly increased concentrations of circulating immunologic complexes in the blood serum and increased percentage values of lymphocytes T, T4, T8, B in the course of postalcoholic liver cirrhosis. Patients with postinflammatory liver cirrhosis treated with isoprinosine mainly showed decreased concentrations of circulating immunologic complexes, immunoglobulins A, M the blood serum, increased percentage values of lymphocytes T4 and T8.
Institut für Klinische Physiologie, Klinik für Infektionskrankheiten, Medizinischen Akademie Białystok.
A
A
Boroń-Kaczmarska
P
P
Boroń
U
U
Puch
A
A
Hryniewicz
E
E
Bobrowska
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000187:drug effects*; D006509:Hepatitis B / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007288:Inosine / Q000031:analogs & derivatives*; D007542:Inosine Pranobex / Q000008:administration & dosage*; D007958:Leukocyte Count / Q000187:drug effects; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000187:drug effects*
D007136:Immunoglobulins; D007288:Inosine; D007542:Inosine Pranobex
Immunmodulatorische Wirkung von Isoprinosine bei Patienten mit postalkoholischer Leberzirrhose.