Regulation of cAMP-inducible genes by CREB.
A large number of neuropeptides and neurotransmitters stimulate neuronal cells through the second messenger cAMP. These synaptic signals often cause profound changes in neuronal function by altering basic patterns of gene expression. Cyclic AMP, in turn, regulates a number of these genes through a conserved cAMP response element (CRE). Recently, a nuclear CRE-binding protein, CREB, has been shown to bind to the CRE and stimulate the transcription of cAMP-responsive genes. This article reviews recent progress towards understanding the mechanism by which cAMP modulates the activity of CREB to stimulate gene transcription.
Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla, CA 92037.
M R
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Montminy
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Gonzalez
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Yamamoto
D000818:Animals; D001483:Base Sequence; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology*; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects*; D008969:Molecular Sequence Data; D015290:Second Messenger Systems; D014158:Transcription, Genetic
D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D000242:Cyclic AMP