X-linked clinical anophthalmos. Localization of the gene to Xq27-Xq28.
A Northern Ireland family is reported on, in which there is X-linked inheritance of clinical anophthalmos. Multi-point linkage analysis suggests that the gene is localized to the Xq27-28 region (Z = 1.9, Theta = 0.08), though not between the DNA markers DX13 and Factor VIII.
Regional Genetics Centre, Belfast City Hospital, Northern Ireland, UK.
C A
CA
Graham
R M
RM
Redmond
N C
NC
Nevin
D000853:Anophthalmos / Q000235:genetics*; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D004247:DNA / Q000032:analysis; D015342:DNA Probes; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012729:Sex Chromosome Aberrations; D014960:X Chromosome
D015342:DNA Probes; D004247:DNA