Effects of repeated administrations of facteur thymique sérique (FTS) on biochemical changes related to aging in senescence-accelerated mouse (SAM).
Superoxide dismutase (SOD) activity,malondialdehyde (MDA) content and monoamine oxidase B (MAO-B) activity were measured in the brain, liver and kidney of a normal aging strain (R/1) and an accelerating aging strain (P/8) senescence-accelerated mice (SAM) at 9-10 months of age, and the effects of facteur thymique sérique (FTS) were examined. The activity of Cu,Zn-SOD in the kidney and MAO-B in the liver was significantly low and high in SAM-P/8 compared to SAM-R/1. FTS enhanced the activity of Mn-SOD and Cu,Zn-SOD in the kidney of SAM-P/8 and Cu,Zn-SOD activity in the brain of both SAM-P/8 and SAM-R/1. It decreased the activity of MAO-B in the liver and the contents of malondialdehyde (MDA) in the brain and kidney of SAM-P/8. Thus, FTS affects the biochemical factors related to senescence in SAM-P/8, a particular senescent animal model, and may thus possibly be effective as an anti-senescent medicine.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
X H
XH
Zhao
A
A
Awaya
H
H
Kobayashi
T
T
Ohnuki
Y
Y
Tokumitsu
Y
Y
Nomura
D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000201:enzymology; D004247:DNA / Q000378:metabolism; D005260:Female; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D008995:Monoamine Oxidase / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013935:Thymic Factor, Circulating / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*
D011506:Proteins; D013951:Thymus Hormones; D008315:Malondialdehyde; D012313:RNA; D004247:DNA; D013935:Thymic Factor, Circulating; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase