Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves.
Aqueous extracts of the seeds of Nigella sativa and mature leaves of Dregea volubilis were administered orally under light ether anaesthesia to male Sprague-Dawley rats for 14 days. Key hepatic enzyme concentrations and histopathological changes in the liver in both treatment groups at the end of 14 days were compared with a control group which received distilled water under identical conditions for 30 days and with a group of normal animals. Serum gamma-glutamyl transferase concentrations were significantly increased in both extract groups while serum alkaline phosphatase concentrations were significantly increased following administration of only D. volubilis when compared with either the control or the normal group. Serum alanine aminotransferase concentrations were significantly increased in both extract groups when compared with the normal group but not with the control group. Degenerative changes in hepatocytes were seen following administration of D. volubilis while consistent significant histopathological changes were not evident following administration of N. sativa.
Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka.
K H
KH
Tennekoon
S
S
Jeevathayaparan
A P
AP
Kurukulasooriya
E H
EH
Karunanayake
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D008099:Liver / Q000201:enzymology; D008297:Male; D010936:Plant Extracts / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000097:blood
D010936:Plant Extracts; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase