Synaptic transmission in the retina.
A recent highlight in the study of the retina has been the publication of evidence that the response of the ON bipolar cells is generated by a cGMP-mediated second messenger system. This GTP-binding protein mechanism is activated by the binding of glutamate, the photoreceptor neurotransmitter, to the 2-amino-4-phosphonobutyrate (APB) class of receptor.
Copenhagen
D R
DR
Department of Ophthalmology, University of California San Francisco 94143-0730.
D000222:Adaptation, Physiological; D000818:Animals; D002450:Cell Communication; D006152:Cyclic GMP / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D004594:Electrophysiology; D005971:Glutamates / Q000378:metabolism / Q000494:pharmacology; D018698:Glutamic Acid; D011493:Protein Kinase C / Q000378:metabolism; D012160:Retina / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D016704:Synapsins / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
D005971:Glutamates; D016704:Synapsins; D018698:Glutamic Acid; D011493:Protein Kinase C; D006152:Cyclic GMP; D004298:Dopamine