Mode of action of the molluscicide bromoacetamide.
1. Uptake of bromoacetamide was found to be upgraded with exposure time (6, 12, 24 hr) and drug concentration (0.1, 0.5, 1.0 ppm). 2. Bromoacetamide was also absorbed by carp and mice, but drug concentration was markedly lower than in snails. Drug clearance from carp as well as from mice is more rapid than that of snails. 3. The ultrastructure of hepatopancreas cells are markedly influenced by bromoacetamide, including swelling of mitochondria and splitting of cristae. This finding is correlative in a decrease in action of enzymes located in mitochondria (ornithine carbamyl-transferase, citric acid synthase). 4. Oxygen uptake and glucose uptake, as well as urea excretion, are reduced and glycogen reserve are decreased.
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
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Wang
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Song
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Becker
D000081:Acetamides / Q000493:pharmacokinetics / Q000633:toxicity*; D000641:Ammonia / Q000652:urine; D000818:Animals; D002347:Carps / Q000378:metabolism; D002950:Citrate (si)-Synthase / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D008975:Molluscacides / Q000493:pharmacokinetics / Q000633:toxicity*; D009954:Ornithine Carbamoyltransferase / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D011869:Radioligand Assay; D012908:Snails / Q000378:metabolism; D013045:Species Specificity; D014508:Urea / Q000652:urine
D000081:Acetamides; D008975:Molluscacides; C016272:N-bromoacetamide; D000641:Ammonia; D014508:Urea; D009954:Ornithine Carbamoyltransferase; D002950:Citrate (si)-Synthase