Effect of omega-conotoxin GVIA on neurotransmitter release at the mouse neuromuscular junction.
The effect of omega-conotoxin GVIA (omega-CgTx) was studied on spontaneous, K(+)-induced and electrically evoked neurotransmitter release at the neuromuscular junction of mouse diaphragm. omega-CgTx decreased the frequency and amplitude of basal and K(+)-induced miniature end plate potentials. This effect was abolished by raising the extracellular Ca2+ concentration. omega-CgTx had no effect on the quantal content of the electrically evoked release in this preparation.
Protti
D A
DA
Instituto de Biologia Celular, Facultad de Medicina, U.B.A., Argentina.
Szczupak
L
L
Scornik
F S
FS
Uchitel
O D
OD
D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D007478:Iontophoresis; D008297:Male; D051379:Mice; D009045:Motor Endplate / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D020866:omega-Conotoxin GVIA
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D018377:Neurotransmitter Agents; D010456:Peptides, Cyclic; D020866:omega-Conotoxin GVIA; D011188:Potassium; D002118:Calcium