[Neuroendocrine control of human reproduction. The role of dopaminergic neurotransmitter systems].
By affecting central hypothalamic processes, the dopaminergic neuronal system governs episodic gonadotropin secretion. Serum gonadotropin profiles as an indirect reflection of central activity can consecutively indicate dopaminergic neurotransmitter activity and its changes by pharmacologic manipulation. Despite vigorous efforts, the role of dopamine in the neuroendocrine control of human reproduction remained contentious. Controversial effects of dopamine on gonadotropin discharge have been observed, presumably a result of different experimental conditions. As yet, numerous investigations have not convincingly evidenced a critical role of dopamine in the regulation of the human menstrual cycle. Since central neuroendocrine mechanisms may not be reduced to action of the dopaminergic system, a complexity of hypothalamic dopaminergic interactions with various neurotransmitters and reproductive hormones should be considered to operate in the biochemical control of the central pulse generator activity.
Frauenklinik und Poliklinik, Universität Ulm.
W G
WG
Rossmanith
D004298:Dopamine / Q000502:physiology*; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D005260:Female; D006065:Gonadotropins, Pituitary / Q000502:physiology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D008598:Menstruation / Q000502:physiology*
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D006065:Gonadotropins, Pituitary; D004298:Dopamine
Neuroendokrine Steuerung der menschlichen Reproduktion: Die Rolle des dopaminergen Neurotransmittersystems.