The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12.
Insulin-like growth factors (IGF) I and II are bound to high-affinity binding proteins in the blood circulation and other body fluids. These IGF-binding proteins are expressed at different concentrations in different tissues and are thought to regulate the activity of IGF I and II. Cloned cDNA for IGF-binding protein-1 (IGFBP1) has been used to verify the location of its gene to human chromosome 7 by Southern blotting to DNA from a human-mouse hybrid cell line. Further, by in situ hybridization the gene was regionally localized to 7p14-p12, and a Mendelian-inherited two-allele BglII restriction enzyme length polymorphism was identified, with the most frequent allele occurring in 53% of the chromosomes.
Ludwig Institute for Cancer Research, Stockholm Branch, Sweden.
J
J
Ekstrand
E
E
Ehrenborg
I
I
Stern
B
B
Stellan
L
L
Zech
H
H
Luthman
D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000648:ultrastructure; D004247:DNA / Q000235:genetics; D005796:Genes; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D004247:DNA