Atenolol, exaprolol and mast cell membranes.
Lipophilic exaprolol and hydrophilic atenolol differ in their interaction with mast cell membranes. Exaprolol, as compared with atenolol, significantly decreased 32P incorporation into, but increased arachidonic acid liberation from, membrane phospholipids. Moreover, exaprolol significantly decreased phosphate incorporation in compound 48/80 and ConA-PS treated cells and decreased thromboxane formation in stimulated cells. On the other hand, atenolol decreased significantly only arachidonate liberation from stimulated mast cells. These results corroborate to some extent the effect of exaprolol and atenolol on histamine liberation which correlates with their membrane perturbing properties.
Pecivová
J
J
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Drábiková
K
K
Jancinová
V
V
Petríková
M
M
Nosál
R
R
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001262:Atenolol / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism*; D003208:Concanavalin A / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000648:ultrastructure*; D008563:Membrane Lipids / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D010718:Phosphatidylserines / Q000494:pharmacology; D010743:Phospholipids / Q000378:metabolism; D010761:Phosphorus Radioisotopes / Q000378:metabolism; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D001095:Arachidonic Acids; D008563:Membrane Lipids; D010710:Phosphates; D010718:Phosphatidylserines; D010743:Phospholipids; D010761:Phosphorus Radioisotopes; D011412:Propanolamines; D003208:Concanavalin A; D016718:Arachidonic Acid; D003189:p-Methoxy-N-methylphenethylamine; D001262:Atenolol; D013929:Thromboxane B2; C012969:exaprolol