HIV envelope glycoprotein, antigen specific T-cell responses, and soluble CD4.
Specific T cells stimulated by antigen presenting cells (APC) pulsed with antigen in the presence of HIV were no longer detectable with a functional assay, which suggests that HIV has been transferred from APC to the specific activated T cell via an antigen-dependent mechanism to exert its cytopathic effect on activated T cells. In contrast soluble gp120 inhibited antigen-driven proliferation, but this action was reversible and could be blocked by soluble CD4. Thus the chief mechanism of HIV pathogenesis may be gp120/CD4 interaction and HIV may be pathogenic mainly as a producer of gp120.
Department of Immunology, University of Genoa, San Martino Hospital, Italy.
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Manca
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Habeshaw
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Dalgleish
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D015704:CD4 Antigens / Q000494:pharmacology*; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology; D000939:Epitopes / Q000032:analysis; D005069:Evaluation Studies as Topic; D015699:HIV Envelope Protein gp120 / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000472:pathogenicity*; D066298:In Vitro Techniques; D007958:Leukocyte Count / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology; D011948:Receptors, Antigen, T-Cell / Q000187:drug effects* / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D013745:Tetanus Toxoid / Q000494:pharmacology; D014373:Tuberculin / Q000494:pharmacology
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D003524:Cyclosporins; D000939:Epitopes; D015699:HIV Envelope Protein gp120; D011948:Receptors, Antigen, T-Cell; D011994:Recombinant Proteins; D013745:Tetanus Toxoid; D014373:Tuberculin