Could preventive intranasal interferon lower the morbidity in children prone to respiratory illness?
Recent studies have demonstrated that rhinovirus infections can be prevented in the family setting through use of intranasal interferon sprays which are commenced when another family member develops a cold. One hundred and twenty-seven children aged 4-9 years who had been hospitalized during their first year of life for severe infections caused by respiratory syncytial virus were studied virologically and epidemiologically during a seven-month period which included the winter months. The hypothesis was that a significant part of their respiratory morbidity would be preventable by a contact prophylaxis approach using intranasal interferon. However, the findings suggest that a preventive approach of this kind would not substantially reduce the burden of respiratory illness in these children because: the target children themselves more often introduced illness into the family than did other household members; rhinovirus infections preventable by interferon were associated with little lower respiratory morbidity; and rhinoviruses were minor contributors to the total respiratory illness burden in these respiratory illness-prone children.
Douglas
R M
RM
National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT.
Moore
B
B
Miles
H B
HB
Pinnock
C B
CB
D000281:Administration, Intranasal; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005192:Family Health; D005260:Female; D006801:Humans; D007372:Interferons / Q000008:administration & dosage*; D008297:Male; D010850:Picornaviridae Infections / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D012229:Rhinovirus
D007372:Interferons