Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepines in rats.
The influence of the opioid receptor antagonist naloxone upon the reduced locomotor activity after administration of nitrazepam (NTZ) and upon the increased locomotion after chronic nitrazepam administration was tested. It was found that a single dose of naloxone counteracted both the reduced locomotion after acute administration of nitrazepam as well as the augmented locomotor activity after chronic application of nitrazepam. It is assumed that opioid mechanisms are involved in the locomotor effects of benzodiazepines.
Department of Pharmacology, Medical Academy, Poznań, Poland.
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Nowakowska
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Chodera
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D004361:Drug Tolerance; D006993:Hypnotics and Sedatives; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D009567:Nitrazepam / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011957:Receptors, Opioid / Q000502:physiology*
D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D011957:Receptors, Opioid; D009270:Naloxone; D009567:Nitrazepam