Suppression of type II collagen-induced arthritis by monoclonal antibodies.
Some mouse monoclonal antibodies raised against chicken type II collagen suppressed or delayed the onset of chicken type II collagen-induced arthritis in DBA/1 mice. This was correlated with the suppression of anti-mouse type II collagen antibody responses following immunization with chicken type II collagen. The epitopes recognized by the suppressive antibodies were found to be present on cyanogen bromide (CB)-digested collagen peptides CB-11 and CB-12. This was also confirmed by the finding that administration of the CB-11 or CB-12 peptide suppressed the induction of arthritis.
Tsukuba Research Laboratories, Esai Co., Ibaraki, Japan.
S
S
Kobayashi
K
K
Terato
Y
Y
Harada
H
H
Moriya
M
M
Taniguchi
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000276:immunology*; D003094:Collagen / Q000276:immunology; D003488:Cyanogen Bromide / Q000378:metabolism; D000939:Epitopes / Q000494:pharmacology; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010455:Peptides / Q000276:immunology / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000939:Epitopes; D010455:Peptides; D003094:Collagen; D003488:Cyanogen Bromide