Antigenic homology among coronaviruses related to transmissible gastroenteritis virus.
The antigenic homology of 26 coronavirus isolates, of which 22 were antigenically related to transmissible gastroenteritis virus (TGEV), was determined with 42 monoclonal antibodies. Type, group, and interspecies specific epitopes were defined. Two group specific MAbs distinguished the enteric TGEV isolates from the respiratory variants. An antigenic subsite involved in neutralization was conserved in porcine, feline, and canine coronavirus. The classification of the human coronavirus 229E in a taxonomic cluster distinct from TGEV group is suggested.
Centro de Biología Molecular, CSIC-UAM, Universidad Autónoma de Madrid, Spain.
C M
CM
Sánchez
G
G
Jiménez
M D
MD
Laviada
I
I
Correa
C
C
Suñé
M j
Mj
Bullido
F
F
Gebauer
C
C
Smerdou
P
P
Callebaut
J M
JM
Escribano
D000818:Animals; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis*; D003332:Coronaviridae / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D000939:Epitopes / Q000032:analysis; D013552:Swine; D005760:Transmissible gastroenteritis virus / Q000276:immunology*; D015678:Viral Structural Proteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes; D015678:Viral Structural Proteins