Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12.
We report here the localization of the gene for a human T-cell-specific molecule, designated RANTES, to human chromosome region 17q11.2-q12 by in situ hybridization and analysis of somatic cell hybrids using a cDNA probe to the gene. We have recently shown that this gene, which encodes a small, secreted, putative lymphokine, is a member of a larger gene family some of whose members reside on chromosome 4 but most of whose members have not to date been mapped. A secondary hybridization peak was noted on the region of human chromosome 5q31-q34, which may represent the location of other members of the gene family. Interestingly, this latter region overlaps with the location of an extended linked cluster of growth factor and receptor genes, some of which may be coregulated with members of the RANTES gene family.
Department of Pathology, Stanford University Medical Center, California 94305.
T A
TA
Donlon
A M
AM
Krensky
M R
MR
Wallace
F S
FS
Collins
M
M
Lovett
C
C
Clayberger
D000595:Amino Acid Sequence; D018946:Chemokine CCL5; D002886:Chromosomes, Human, Pair 17; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008222:Lymphokines / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009693:Nucleic Acid Hybridization; D012689:Sequence Homology, Nucleic Acid; D013601:T-Lymphocytes
D018946:Chemokine CCL5; D008222:Lymphokines