Distinct gamma/delta T cell receptors define two subsets of circulating porcine CD2-CD4-CD8- T lymphocytes.
The species swine provides the only example for CD2+ and CD2- subsets of Ig-CD4-CD8- lymphocytes with the propensity for homing to lymphoid tissue (Saalmüller et al., Eur. J. Immunol. 1989. 19: 2011). That the CD2-CD4-CD8- lymphocytes are bare of marker molecules that typify T lymphocytes raised the question of whether or not this cell type is descended from the T lymphocyte differentiation lineage. It is documented that expression of a phylogenetically conserved external epitope of T cell receptor gamma/delta subdivides porcine CD2- lymphocytes into an epitope 86D+ minor and an 86D- major subset. Expression of distinct forms of the T cell receptor gamma/delta, disulfide-bonded N-glycosylated surface heterodimers of under reducing conditions 38/40 and 37/40 kDa, respectively, hallmarks the CD2-86D+ and CD2-86D- subsets both as T lymphocytes.
Federal Research Centre for Virus Diseases of Animals, Tübingen, FRG.
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Hirt
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Saalmüller
M J
MJ
Reddehase
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D018801:CD2 Antigens; D017252:CD3 Complex; D015704:CD4 Antigens / Q000032:analysis; D016827:CD8 Antigens; D002469:Cell Separation; D004220:Disulfides / Q000032:analysis; D015180:Electrophoresis, Gel, Two-Dimensional; D000939:Epitopes; D005434:Flow Cytometry; D011233:Precipitin Tests; D011948:Receptors, Antigen, T-Cell / Q000032:analysis / Q000145:classification* / Q000276:immunology; D011971:Receptors, Immunologic / Q000032:analysis; D013552:Swine / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D004220:Disulfides; D000939:Epitopes; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic