Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing.
The expression of two alternative splice variants, Flip and Flop, in mRNAs encoding the four AMPA-selective glutamate receptors (GluR-A, -B, -C, and -D) was studied in the developing brain by in situ hybridization. These receptors are expressed prominently before birth, and patterns of distribution for Flip versions remain largely invariant during postnatal brain development. In contrast, the Flop versions are expressed at low levels prior to postnatal day 8. Around this time, the expression of Flop mRNAs increases throughout the brain, reaching adult levels by postnatal day 14. Thus, receptors carrying the Flop module appear to participate in mature receptor forms.
Laboratory of Molecular Neuroendocrinology, University Heidelberg, Germany.
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H
Monyer
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PH
Seeburg
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W
Wisden
D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D002531:Cerebellum / Q000196:embryology / Q000378:metabolism; D015870:Gene Expression; D006624:Hippocampus / Q000196:embryology / Q000378:metabolism; D007051:Ibotenic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D011810:Quinoxalines / Q000378:metabolism; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000235:genetics* / Q000378:metabolism; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D015345:Oligonucleotide Probes; D011810:Quinoxalines; D012333:RNA, Messenger; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D007051:Ibotenic Acid; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid