The effects of low-dose Bay-m-1099 (Miglitol) on serum lipids and liver enzyme activity of obese and obese-diabetic corpulent rats.
1. Groups of lean, obese, and obese-non-insulin-dependent diabetic LA/N-cp and SHR/N-cp rats were administered the a-glucosidase inhibitor Miglitol (150 mg/kg diet, ad libitum) from 8 until 15 weeks of age. 2. Phenotype effects (obese greater than lean) were present for weight gain, adiposity, serum glycemic and lipid parameters, and for liver glucokinase, glucose-6-phosphate dehydrogenase, and malic enzyme activity. Miglitol treatment was associated with improvements in glucokinase and malic enzyme in both strains, and in improvements in glycemic parameters in obese rats. 3. These results are consistent with variable improvements in glycemic control and insulin action following low dose Miglitol treatment, and indicate that indirect effects of the drug on insulin sensitivity in peripheral tissues and on glucoregulatory enzymes may contribute to the glycemic improvements observed with this drug, while greater dosages or longer treatment may be required to observe comparable improvements in adiposity or plasma lipid profiles.
Department of Nutrition and Food Science, College of Arts and Sciences, Drexel University, Philadelphia, PA 19104.
O L
OL
Tulp
B
B
Szepesi
O E
OE
Michaelis
J F
JF
DeBouno
D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives; D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000473:pathology; D005941:Glucokinase / Q000378:metabolism; D005944:Glucosamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D050112:Imino Pyranoses; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009765:Obesity / Q000378:metabolism* / Q000473:pathology; D010641:Phenotype; D051381:Rats; D015430:Weight Gain / Q000187:drug effects
D001786:Blood Glucose; D001798:Blood Proteins; D065089:Glycoside Hydrolase Inhibitors; D050112:Imino Pyranoses; D007328:Insulin; D008055:Lipids; C045621:miglitol; D017485:1-Deoxynojirimycin; D005954:Glucosephosphate Dehydrogenase; D005941:Glucokinase; D005944:Glucosamine