Interleukin-2 receptor antigen, leukocyte common antigen, and Ki-1 antigen-expressing gastric plasmacytoma. A case report with an immunohistochemical study.
A case of primary gastric plasmacytoma expressing various surface and cytoplasmic antigens is reported. With the use of formalin-fixed and deparaffinized sections, 13 different antibodies were applied. Neoplastic plasma cells revealed monoclonal IgG and kappa light chain in the cytoplasm, and expressed epithelial membrane antigen, Ki 67 antigen, cytokeratin, CD 22 antigen, interleukin-2 receptor antigen, leukocyte common antigen and Ki-1 (CD 30) antigen. However, tumor cells were devoid of HLA-DR antigen. These data suggest that the neoplastic plasma cells are at the plasmoblastic stage of maturation and express various surface and cytoplasmic phenotypes.
Second Department of Pathology, Ehime University School of Medicine, Japan.
T
T
Ohmori
N
N
Uraga
K
K
Komi
R
R
Tabei
R
R
Matsuda
T
T
Kodama
K
K
Iwahashi
D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000378:metabolism*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D000951:Antigens, Neoplasm / Q000378:metabolism*; D000954:Antigens, Surface / Q000378:metabolism; D015815:Cell Adhesion Molecules; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007633:Keratins / Q000378:metabolism; D017730:Ki-1 Antigen; D019394:Ki-67 Antigen; D037102:Lectins; D017493:Leukocyte Common Antigens; D008562:Membrane Glycoproteins / Q000378:metabolism; D018396:Mucin-1; D010954:Plasmacytoma / Q000276:immunology / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D051918:Sialic Acid Binding Ig-like Lectin 2; D013274:Stomach Neoplasms / Q000276:immunology / Q000378:metabolism*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; C497867:CD22 protein, human; D015815:Cell Adhesion Molecules; D017730:Ki-1 Antigen; D019394:Ki-67 Antigen; D037102:Lectins; D008562:Membrane Glycoproteins; D018396:Mucin-1; D015375:Receptors, Interleukin-2; D051918:Sialic Acid Binding Ig-like Lectin 2; D007633:Keratins; D017493:Leukocyte Common Antigens