Retrograde transport of fluoro-gold in corticospinal and rubrospinal neurons 10 and 20 weeks after T-9 spinal cord transection.
Retrograde labeling with horseradish peroxidase is greatly diminished in corticospinal and rubrospinal neurons axotomized by complete T-9 spinal cord transection. We found, 10 or 20 weeks after a complete T-9 cord transection, that the number of corticospinal and rubrospinal neurons retrogradely labeled after Fluoro-Gold insertion into a new transection at T-1 did not differ from that of controls. While transection alters uptake, transport, and/or intracellular metabolism of some transportable substances, it does not affect the ability of the neurons to be retrogradely labeled with Fluoro-Gold.
Veterans Administration Medical Center, Augusta, Georgia.
R L
RL
McBride
E R
ER
Feringa
M K
MK
Garver
J K
JK
Williams
D000818:Animals; D001370:Axonal Transport; D001369:Axons / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology*; D005260:Female; D005456:Fluorescent Dyes; D009416:Nerve Regeneration; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012012:Red Nucleus / Q000166:cytology*; D013116:Spinal Cord / Q000166:cytology* / Q000502:physiology / Q000601:surgery; D013266:Stilbamidines
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines