[Synthesis of nucleic acids and dynamics of morphological indices of the granulation tissue of skin wounds in rats treated with 4-methyluracil].
Effect of 4-methyl uracil on dynamics of morphological patterns and the rate of nucleic acids synthesis was studied in granulation tissue developed during healing of full-layer skin wounds. Application of ointment containing 4-methyl uracil onto the wounds exhibited an antiinflammatory efficiency and decreased accumulation of leukocytes in the wound. The drug shortened the mitotic cycle in dividing fibroblasts, as a result of which periods of DNA synthesis became more frequent exhibiting two days duration. The rate of RNA synthesis was increased 1.5-2-fold. Content of acid glycosaminoglycans and collagen was increased in intercellular space surrounding fibroblasts.
Silaeva
S A
SA
Khatsernova
B Ia
BIa
Golenchenko
V A
VA
Berchenko
G N
GN
Nikolaev
A Ia
AIa
Shekhter
A B
AB
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D006097:Granulation Tissue / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012867:Skin / Q000293:injuries; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
D014498:Uracil; D012313:RNA; D004247:DNA
Sintez nukleinovykh kislot i dinamika morfologicheskikh pokazateleĭ granuliatsionnoĭ tkani kozhnykh ran u krys, lechennykh 4-metiluratsilom.