Loss of heterozygosity on chromosome 3, bands q24----qter, in a diploid meningioma.
Cytogenetic analysis of a meningioma from a 46-year-old female patient exhibited as the sole cytogenetic aberration a deletion on the long arm of one chromosome 3 involving bands 3q24----qter. To verify this finding, RFLP analysis was performed with two polymorphic probes, MOX2 and D3S5. The patient was informative for both single copy probes and demonstrated loss of heterozygosity in the region above whereas chromosome 22 displayed no loss of heterozygosity as judged by a proximal and a distal probe.
Institut für Humangenetik, Universitätsklinik, Homburg, Germany.
U
U
Färber
G
G
Schneider
U M
UM
Schrell
P
P
Fahlbusch
E F
EF
Adams
N
N
Blin
W
W
Henn
D002871:Chromosome Banding; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006579:Heterozygote; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000473:pathology; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008579:Meningioma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length