Beta-2-adrenoceptors of polymorphonuclear leukocytes in children with atopic dermatitis. Their number and affinity to the radioligand [125I]-cyanopindolol.
[125I]-cyanopindolol (ICYP) was used in a binding assay to compare the number and affinity of beta 2-adrenoceptor binding sites on circulating polymorphonuclear leukocytes (PMN) of 21 children with atopic dermatitis (AD) and 23 age-matched controls. We found no correlation between the beta 2-adrenoceptor density and the age of the children in either collective. Furthermore, the number and affinity of beta 2-adrenoceptor binding sites on PMN was neither influenced by sex nor severity of disease, serum IgE level or percentage of eosinophils in the differential blood count. There was a tendency towards a lower number of beta 2-adrenoceptors in AD subjects (1,429 +/- 587 receptors/PMN) compared to controls (1,753 +/- 596 receptors/PMN), but this difference was statistically not significant.
Department of Pediatrics, University of Freiburg, FRG.
A
A
Pohl
J
J
Otto
R
R
Urbanek
D000293:Adolescent; D000319:Adrenergic beta-Antagonists; D001665:Binding Sites; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009504:Neutrophils / Q000378:metabolism*; D010869:Pindolol / Q000031:analogs & derivatives / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000096:biosynthesis*
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; C047975:cyanopindolol; D010869:Pindolol