A novel treatment for ischemic intracranial hypertension in cats.
There is no accepted efficacious treatment for ischemic cerebral edema. We show in a cat model of focal cerebral ischemia that infarct volume can be reduced (p less than 0.05) by ventriculocisternal perfusion with an oxygenated fluorochemical emulsion (bis-perfluorobutylethylene). An accompanying effect of such ventriculocisternal perfusion is a reduction in intracranial pressure. At 18 hours following the start of the perfusion, there was a significant (p less than 0.05) difference in intracranial pressure between nonperfused controls (mean 11.4 [range 2.3-23.0] torr, n = 6) and cats perfused with an oxygenated nutrient solution not containing fluorochemical (mean 11.3 [range 3.0-29.0] torr, n = 8) or animals perfused with the oxygenated fluorochemical emulsion (mean 2.21 [range 0-3.5] torr, n = 7). Perfusion with this oxygenated fluorochemical emulsion warrants further study as a treatment for elevated intracranial pressure.
Bell
R D
RD
Department of Neurology, Thomas Jefferson Medical College, Philadelphia, Pa 19107.
Frazer
G D
GD
Osterholm
J L
JL
Duckett
S W
SW
D000818:Animals; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000503:physiopathology*; D002415:Cats; D002544:Cerebral Infarction / Q000473:pathology; D005466:Fluorocarbons / Q000494:pharmacology*; D007427:Intracranial Pressure; D008297:Male; D010477:Perfusion; D013194:Staining and Labeling; D013778:Tetrazolium Salts
D005466:Fluorocarbons; D013778:Tetrazolium Salts; C009591:triphenyltetrazolium; C057576:bis(perfluorobutyl)ethene