Fludarabine phosphate therapy of non-Hodgkin's lymphoma.
Fludara I.V. (fludarabine phosphate) was tested by the Eastern Cooperative Oncology Group in non-Hodgkin's lymphoma patients who failed or relapsed after prior chemotherapy and radiation. Fifty-seven patients with low- or intermediate-grade (working formulation) lymphoma were treated with 18 mg/m2 daily for 5 days every 28 days. Preliminary data analysis shows an overall response (complete response [CR] plus partial response [PR]) rate of 28%, consisting of 18% CR and 27% PR in patients with low-grade histologies and 11% CR and 6% PR in patients with intermediate-grade histologies. Toxicity was mild and mainly included moderate myelosuppression. A 9% incidence of reversible neurologic side effects was seen. Based on this activity in previously treated patients, combination studies with Fludara I.V. in untreated patients are planned.
Division of Medical Oncology, Kaplan Cancer Center, New York University Medical Center, NY 10016.
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Hochster
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Cassileth
D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced; D012074:Remission Induction; D015996:Survival Rate; D001084:Vidarabine Phosphate / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000964:Antimetabolites, Antineoplastic; D001084:Vidarabine Phosphate; C042382:fludarabine phosphate