Oxidative stress of red blood cells stored for transfusion use.
Some oxidative indexes and the level of reduced glutathione have been determined on red blood cells stored for transfusion use. Conjugated dienes show a concentration which increases until around the third week of storage and then comes back to lower values. On the contrary malonyldialdeyde shows a decreasing level until the third week and then rises rapidly to very high values. Reduced glutathione rises until about the end of the second week and then falls to very low values. Free haemoglobin continuously rises through the whole period of storage; from these data it is evident that a storage time not exceeding 21 days gives the best transfusion results.
Istituto di Semeiotica Medica, Università Cattolica S. Cuore, Roma, Italy.
S
S
Lippa
F
F
Forni
A
A
Candido
V
V
Aureli
G
G
Mango
D000475:Alkenes / Q000097:blood; D001793:Blood Preservation; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D010100:Oxygen / Q000097:blood; D013997:Time Factors
D000475:Alkenes; D006454:Hemoglobins; D008054:Lipid Peroxides; D008315:Malondialdehyde; D005978:Glutathione; D010100:Oxygen