Multicenter study with isradipine and diuretics against atherosclerosis. US MIDAS Research Group.
Hypertension is a major risk factor for atherosclerosis. Although antihypertensive drug treatment can reduce morbidity and mortality from stroke, there is no consistent benefit on ischemic heart disease. It may be that subtle adverse effects of the drugs used in these clinical trials may have blunted the beneficial effects of treatment. Isradipine, a new calcium antagonist of the dihydropyridine class, is a potent antihypertensive drug with pronounced antiatherogenic properties, at least in animal studies. Thus, isradipine may be a suitable drug for assessing the efficacy of antihypertensive treatment in retarding the progression of atherosclerosis. The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a clinical trial to compare the efficacy of isradipine (2.5-5.0 mg b.i.d.) and hydrochlorothiazide (12.5-25 mg b.i.d.) in retarding atherosclerosis in carotid arteries. Carotid atherosclerosis will be monitored using B-mode ultrasonography. The sample size is 800 men and women aged 40 years and over. The power of the design is 90% to detect a 30% difference in the progression of plaque size between the isradipine- and hydrochlorothiazide-treated groups with a significance level of 5% (p = 0.05).
Borhani
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NO
Department of Community Health, School of Medicine, University of California, Davis 95616.
Brugger
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SB
Byington
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RP
D001161:Arteriosclerosis / Q000188:drug therapy* / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002340:Carotid Artery Diseases / Q000188:drug therapy / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000188:drug therapy / Q000503:physiopathology; D004232:Diuretics / Q000627:therapeutic use*; D004562:Electrocardiography; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D017275:Isradipine; D015337:Multicenter Studies as Topic; D011725:Pyridines / Q000627:therapeutic use*; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012039:Regional Blood Flow; D012107:Research Design
D002121:Calcium Channel Blockers; D004232:Diuretics; D007328:Insulin; D011725:Pyridines; D006852:Hydrochlorothiazide; D017275:Isradipine