CD4+ and CD56+ acute monoblastic leukemia.
We report here a patient with acute monoblastic leukemia whose leukemia cells had CD4 (T4) and CD56 (NKH-1) antigens, in addition to CD36 (OKM5) antigen. The leukemia cells did not have NK or ADCC activities. They showed no rearrangements of immunoglobulin heavy (IgH) chain and T cell receptor (TCR)-beta chain genes, indicating that the leukemia cells were nonlymphoid. The presence of this case suggests that leukemia cells could be originated from monocytes with NK-associated antigen without IgH or TCR rearrangements.
First Department of Internal Medicine, Tokyo Medical College, Japan.
T
T
Tauchi
K
K
Ohyashiki
J H
JH
Ohyashiki
Y
Y
Kawanishi
Y
Y
Kimura
M
M
Saito
S
S
Nakazawa
Y
Y
Kawai
K
K
Toyama
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D000943:Antigens, Differentiation / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D018955:CD36 Antigens; D015704:CD4 Antigens / Q000032:analysis*; D019002:CD56 Antigen; D005838:Genotype; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000276:immunology* / Q000473:pathology; D008297:Male; D009000:Monocytes / Q000276:immunology
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D018955:CD36 Antigens; D015704:CD4 Antigens; D019002:CD56 Antigen