[Chlorine channels activated by suberyldicholine in mollusk neurons].
Patch-clamp technique in cell-attached configuration was applied to investigate ion permeability induced by suberyldicholine in the neurons of freshwater mollusc Planorbarius corneus. The inward currents through single channels were registered at patch potentials 50-100 mV more negative than resting potential of the cell. When the patch pipette contained suberyldicholine (5 mol/l), single channel currents were recorded which grouped in bursts and bursts of openings could themselves be grouped together in clusters of bursts. The desensitisation was not too pronounced: usually we were able to observe single-channel currents for 20-30 minutes. The unit conductance gamma was found to be about 10 pS.
A N
AN
Kachman
E V
EV
Frolova
S A
SA
Gapon
D000818:Animals; D002712:Chlorides / Q000378:metabolism*; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects* / Q000502:physiology; D008974:Mollusca / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology
D002712:Chlorides; D007473:Ion Channels; D011950:Receptors, Cholinergic; C009335:subecholine; D002794:Choline
Khlornye kanaly, aktiviruemye suberildikholinom v neĭronakh molliuska.