Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene.
Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed between LQT and H-ras-1, and there is a physiological rationale for its involvement in this disease, ras becomes a candidate for the disease locus.
Keating
M
M
Department of Human Genetics, University of Utah Health Sciences Center, Salt Lake City 84132.
Atkinson
D
D
Dunn
C
C
Timothy
K
K
Vincent
G M
GM
Leppert
M
M
D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004562:Electrocardiography; D011905:Genes, ras; D006801:Humans; D008126:Lod Score; D008133:Long QT Syndrome / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length