Short-term facilitation as a tool to know neuromodulator-induced change in Ca2+ movement in the nerve terminal.
A theory was developed to show how we can predict the actions of neuromodulators on Ca2+ movement (yo: impulse-induced increase in Ca2+ concentration; c: basal Ca2+ level) in the nerve terminal from their effects on an impulse-evoked transmitter release (m: quantal content) and short-term facilitation (F) elicited by paired impulses, based on the simplest version of the residual Ca2+ hypothesis of facilitation. It was demonstrated from this theory that yo should be increased (decreased) when both m and F were increased (decreased) and that c should be increased (decreased) when m and F were increased (decreased) and decreased (increased), respectively. These ideas could interpret some published experimental results well.
Kumamoto
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Department of Physiology, Saga Medical School, Japan.
D000818:Animals; D001001:Anura; D002118:Calcium / Q000378:metabolism*; D008433:Mathematics; D008959:Models, Neurological; D009411:Nerve Endings / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000502:physiology*
D018377:Neurotransmitter Agents; D002118:Calcium