[The causes of appearance of a double insertion of homogeneously staining regions in the chromosome 1 of house mouse (Mus musculus musculus)].
A high resolution analysis of G-band pattern of normal and aberrant chromosome 1 bearing two linked insertions of homogeneously staining regions (HSRs) in the house mouse (Mus musculus musculus) reveals an inverted pattern of the euchromatic region between the HSRs. On the basis of this analysis, a hypothesis on the causes for appearance of the aberrant chromosome was put forward: the double insertion is a result of inversion of the chromosome 1 of Mus musculus domesticus bearing a single long insertion. The proximal breakpoint is localized inside the HSR and the distal one--between subbands E3 and E4. From the point of view of these data, new symbols for the aberrations are proposed: Ls (HSR, 1C5) 1Icg--for the proximal insertion, Is(HSR, 1D)21cg--for the distal one, In (1) 1Icg--for the inverted region, including the bands D, E1-E3 and the insertion Is(HSR 1D)21cg.
S I
SI
Agul'nik
P M
PM
Borodin
I P
IP
Gorlov
T Iu
TIu
Ladygina
S D
SD
Pak
D000818:Animals; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D007621:Karyotyping; D051379:Mice / Q000235:genetics*; D013194:Staining and Labeling
Prichiny vozniknoveniia dvoĭnoĭ insertsii gomogenno okrashivaemykh raĭonov v 1-ĭ khromosome domovoĭ myshi (Mus musculus musculus).