Neovascularization occurs in response to crush lesions of adult frog optic nerves.
The capacity of the adult frog optic nerve to regenerate following a crush lesion is well established and is in contrast to the lack of regeneration of mammalian optic nerves after similar lesions. One factor which may contribute to the enhanced regenerative capacity of amphibian optic nerves is the rapid removal of cellular debris from the nerve after injury. In this study the morphology of normal and crushed frog optic nerves has been compared. Although the intraorbital region of the normal adult frog optic nerve is avascular, new intraparenchymal blood vessels appear central to the crush site 24 h after the nerve lesion. The appearance of these blood vessels is coincident with the appearance of granulocytes and macrophages in the nerve. Successful regeneration of the adult frog optic nerve may depend on this neovascularization to facilitate the rapid removal of cellular debris and to supply regenerating axons with trophic substances.
Department of Anatomy and Cell Biology, Eastern Virginia Medical School, Norfolk 23501.
F J
FJ
Liuzzi
R H
RH
Miller
D000818:Animals; D008297:Male; D009389:Neovascularization, Pathologic; D009409:Nerve Crush; D009416:Nerve Regeneration; D009900:Optic Nerve / Q000098:blood supply* / Q000502:physiology; D011894:Rana pipiens / Q000502:physiology*; D013997:Time Factors