Propafenone induced acute variation of chronic atrial pacing threshold: a case report.
A marked increase of chronic atrial pacing threshold resulting in loss of atrial capture, induced by propafenone, is reported in a patient with bradycardia-tachycardia syndrome. After atrial pacemaker implant, the atrial threshold had been measured repeatedly noninvasively and shown to be stable. The threshold rise and loss of atrial capture occurred after 7 days of treatment with propafenone at the dosage of 450 mg daily; drug withdrawal resulted in resumption of atrial capture and a return to prior pacing thresholds.
Montefoschi
N
N
Division of Cardiology, S. Filippo Neri Hospital, Rome, Italy.
Boccadamo
R
R
D001283:Atrioventricular Node / Q000187:drug effects; D001919:Bradycardia / Q000188:drug therapy / Q000628:therapy; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011405:Propafenone / Q000009:adverse effects*; D013577:Syndrome; D013610:Tachycardia / Q000188:drug therapy / Q000628:therapy
D011405:Propafenone