Determination of neurochemicals in biological fluids by using an automated high-performance liquid chromatographic system with a coulometric array detector.
The chromatographic separation of 33 neurochemicals was achieved by using a combined gradient of organic modifier, pH and counter-ion. A secondary separation of unresolved analytes was obtained by using electrochemical detection with a coulometric array of sixteen electrodes. The stability of the analytes was studied and data on analytical performance are reported in addition to a list of neurochemicals detected in a normal plasma sample.
Servizio Analisi Chimico Cliniche e Neurochimica, IRCCS Istituto Neurologico C. Mondino, Università di Pavia, Italy.
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Rizzo
G M
GM
d'Eril
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G
Achilli
G P
GP
Cellerino
D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D006801:Humans; D018377:Neurotransmitter Agents / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid
D018377:Neurotransmitter Agents