Immunological tolerance to many self epitopes may be unnecessary.
The demonstration of the existence of antigenic mimicry suggests that immunological tolerance to self antigens may be an insufficient basis for distinguishing self from non-self. However, some data suggest that even in the absence of tolerance most self epitopes would not immunize the host and that tolerance to all self epitopes may, therefore, not be necessary for the prevention of autoimmune disease.
Department of Pathology, University of Washington, Seattle.
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D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D000939:Epitopes; D006085:Graft Survival; D006243:Harderian Gland / Q000098:blood supply / Q000637:transplantation; D006649:Histocompatibility Antigens / Q000276:immunology; D007108:Immune Tolerance; D013950:Thymus Gland / Q000098:blood supply / Q000637:transplantation
D000951:Antigens, Neoplasm; D001324:Autoantigens; D000939:Epitopes; D006649:Histocompatibility Antigens