[The covalent binding of a potent beta-receptor blocker (B 24/76) on tissue proteins and collagen in the rat].
Toxic effects of drugs and their metabolism may be caused by covalent binding to cellular macromolecules. After oral application of the tritiated beta-blocker B 24/76 to male Wistar rats only the liver showed a significant irreversible binding to tissue proteins, with 11% of the radioactivity distributed in this organ. A covalent binding to collagen was found in liver, lung and muscle. The highest part was measured in the lung with 7% of the radioactivity distributed in this organ.
Baumann
A
A
Institut für Pharmakologie und Toxikologie, Ernst-Moritz-Arndt-Universität Greifswald.
Möritz
K U
KU
D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics*; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D011412:Propanolamines / Q000493:pharmacokinetics*; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C058041:B 24-76; D003094:Collagen
Untersuchungen zur kovalenten Bindung eines potentiellen beta-Rezeptorenblockers (B 24/76) an Gewebsproteine und Kollagen bei der Ratte.