[Assessment of anti-arrhythmic activity of palpitin and cardio-hemodynamic effects of its administration].
Palpitin, an agent of the disopyramide series, was evaluated for its antiarrhythmic potency in the treatment of ventricular and supraventricular arrhythmias and for its effects of ECG and central hemodynamic parameters in 108 patients (91 had coronary heart disease, 8 presented with postmyocardial cardiosclerosis, 5 had hypertensive disease, and 4 suffered from neurocirculatory dystonia). 24-hour ECG monitoring and echocardiography were employed in the study. It was concluded that the drug possessed a high antiarrhythmic potency. No substantial changes were found in the mean values of echocardiographic parameters, as well as of atrioventricular and intraventricular conduction.
Kurakina
T I
TI
Gorshkov
V A
VA
Nesvetov
V N
VN
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy; D004206:Disopyramide / Q000031:analogs & derivatives* / Q000494:pharmacology; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged
D004206:Disopyramide
Otsenka antiaritmicheskoĭ aktivnosti pal'pitina i kardiogemodinamicheskie éffekty ego primeneniia.