Clinical signs and laboratory markers in predicting progression to AIDS in HIV-1 infected patients.
In a prospective longitudinal study 89 men with HIV-1 infection were observed for a mean time of 51 months with regard to clinical signs and laboratory findings predictive of progression to AIDS/opportunistic infection (OI). In a bivariate regression analysis the clinical signs showing a significant relation to AIDS development were: dermatitis of the face, yellow toe nail changes, hairly leukoplakia and oral candidiasis. The laboratory findings significantly associated with progression to AIDS were: decrease of the relative and absolute number of CD4 lymphocytes, decrease of the CD4/CD8 ratio, HIV p24 antigenaemia, lack of anti-HIV p24, elevated erythrocyte sedimentation rate, anaemia and elevated serum-beta-2-microglobulin. The relative number (%) of CD4 cells was found superior to the absolute number and the CD4/CD8 ratio. In a multivariate regression analysis decrease of CD4 lymphocytes and lack of anti-HIV p24 were independently associated with subsequent AIDS/OI development.
Department of Infectious Diseases, Roslagstull Hospital, Stockholm, Sweden.
L
L
Morfeldt-Månson
B
B
Böttiger
B
B
Nilsson
L V
LV
von Stedingk
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D000740:Anemia / Q000150:complications; D001727:Bisexuality; D001799:Blood Sedimentation; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes; D002180:Candidiasis, Oral / Q000150:complications; D003872:Dermatitis / Q000150:complications; D005145:Face; D016655:HIV Core Protein p24 / Q000097:blood; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis*; D006716:Homosexuality; D006801:Humans; D007958:Leukocyte Count; D007972:Leukoplakia, Oral / Q000150:complications; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009262:Nails / Q000473:pathology; D009894:Opportunistic Infections / Q000150:complications*; D011379:Prognosis; D011446:Prospective Studies; D012044:Regression Analysis; D014034:Toes; D001613:beta 2-Microglobulin / Q000032:analysis
D016655:HIV Core Protein p24; D001613:beta 2-Microglobulin