[The role of hemorheologic changes in the pathogenesis of acute hemorrhagic necrotizing pancreatitis].
The hemorheologic alterations were studied in experimental acute hemorrhagic necrotizing pancreatitis (AHNP) which was induced by injection of 5% sodium taurocholate into the main pancreatic duct. The results showed that during the early stage of AHNP, all of hemorheologic parameters were significantly elevated, and continually increased at the rest intervals. The authors suggested that the blood viscosity and hematocrit increase, red blood cells tend to aggregate, and erythrocyte deformation decrease are the causation of pancreatic microcirculatory disturbances and promoting pancreatic progressive necrosis. After using low molecular dextran and Salvia miltiorrhizae, the hemorheologic alterations in AHNP were recovered, and the histologic observation improved. Our data indicate the hemorheologic disturbances is one of the key factors in the pathogenesis of AHNP.
Yan
L
L
Wei
J
J
Wu
H
H
Chen
H
H
Zhong
G
G
Li
L
L
Chen
L
L
Li
K
K
Tan
J
J
D000208:Acute Disease; D000818:Animals; D001775:Blood Circulation; D001809:Blood Viscosity / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D004365:Drugs, Chinese Herbal; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology; D008297:Male; D008833:Microcirculation; D010179:Pancreas / Q000098:blood supply; D010195:Pancreatitis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D010618:Phenanthrolines / Q000494:pharmacology; D010936:Plant Extracts; D027561:Salvia miltiorrhiza
D003911:Dextrans; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D010618:Phenanthrolines; D010936:Plant Extracts; C028972:dan-shen root extract