Evidence for the existence of angiotensin II like immunoreactivity in subpopulations of tyrosine hydroxylase immunoreactive neurons in the A1 and C1 area of the ventral medulla of the male rat.
By using double immunolabelling techniques the possible coexistence of tyrosine hydroxylase (TH)- and angiotensin II (ANG II)-like immunoreactivities (IR) has been studied within the noradrenaline A1 and adrenaline C1 areas of the ventral medulla of the rat. In the A1 area 20-30% of the TH IR nerve cell bodies were ANG II IR and in the C1 area 5-40% of the TH IR nerve cell bodies displayed ANG II IR. These results suggest the existence of ANG II/NA and ANG II/A costoring neurons in the A1 and C1 group, respectively, opening new possibilities for ANG II-catecholamine interactions in cardiovascular and neuroendocrine regulation.
Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.
R
R
Coveñas
K
K
Fuxe
A
A
Cintra
J A
JA
Aguirre
M
M
Goldstein
D
D
Ganten
D000818:Animals; D005455:Fluorescent Antibody Technique; D007106:Immune Sera; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology* / Q000166:cytology / Q000201:enzymology; D009474:Neurons / Q000166:cytology* / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000032:analysis*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*
D007106:Immune Sera; D013373:Substance P; D014446:Tyrosine 3-Monooxygenase