Increased frequency of HLA-DRw14b(w6)-associated RFLP in Greenlanders of Eskimo origin.
HLA-DR typing by the restriction fragment length polymorphism (RFLP) technique of 42 Greenlanders living in northern Jutland, Denmark, revealed a phenotype frequency of 33.3% for HLA-DRw14b(w6), which is significantly different from the frequency of 0.0% observed among 98 Danes of Caucasian origin. When comparing the two populations, the frequency of other HLA-DRB allogenotypes show insignificant variations. Since HLA-DRw14b(w6) is carried by approximately one-third of the Greenlanders tested, this allogenotype may serve as a useful marker in further anthropological and immunogenetic studies.
Regional Center for Blood Transfusion and Clinical Immunology, Aalborg Hospital, Denmark.
N
N
Grunnet
R
R
Steffensen
C
C
Jersild
D003718:Denmark; D005787:Gene Frequency; D005838:Genotype; D006116:Greenland / Q000208:ethnology; D006684:HLA-DR Antigens / Q000235:genetics*; D059810:HLA-DR Serological Subtypes; D006801:Humans; D004930:Inuit / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C052238:HLA-DR14