[The influence of umbilical cord compression on the fetal brain--an animal experiment using laser spectroscopy].
In order to evaluate the influence on the fetal brain due to compression of the umbilical cord biochemical and biophysical changes were traced during defined occlusions of 60 sec by means of NIR laser spectroscopy. Synchronously blood samples were drawn intermittently from a catheter positioned in the A. carotis and analysed for blood gases. The saturation values measured in the fetal blood correlated significantly with the dates of the HbO2 tracing of the NIR-system (r = 0.81, p less than 0.001). After induced occlusion of the umbilical cord a reproducible pattern of the NIR tracing occurred. While an immediate fall in HbO2 occurred, a synchronous rise in desaturated Hb was observed. For the changes of the cytochrome aa3 we detected a minor decrease that occurred with a lag time. Additionally there was an indication of a major change of blood volume as the total Hb content augmented during each compression. We concluded: Changes of Hb-saturation in the fetal blood are immediately indicated by NIR-laser spectroscopy. During cord occlusion of 60 sec. the intracellular oxygenation decrease only after a significant lag time and are reversible and furthermore it leads to a reproducible change of intracerebral blood volume.
Universitäts-Frauenklinik, Bonn.
S
S
Schmidt
W
W
Decleer
S
S
Gorissen-Bosselmann
K
K
Pringle
N
N
Helledie
P
P
Rolfe
D
D
Krebs
D000818:Animals; D001810:Blood Volume; D001923:Brain Chemistry; D002560:Cerebrovascular Circulation; D003250:Constriction; D003576:Electron Transport Complex IV / Q000097:blood; D005312:Fetal Blood / Q000737:chemistry*; D005319:Fetal Hemoglobin / Q000032:analysis; D005333:Fetus / Q000378:metabolism*; D007834:Lasers; D010100:Oxygen / Q000097:blood; D012756:Sheep; D013055:Spectrophotometry, Infrared; D014470:Umbilical Cord
D005319:Fetal Hemoglobin; D003576:Electron Transport Complex IV; D010100:Oxygen
Die Belastung des fetalen Gehirns bei Nabelschnurkompression--eine tierexperimentelle Studie mittels Laserspektroskopie.