Localization of the normal cellular src protein to the growth cone of differentiating neurons in brain and retina.
The protooncogene c-src is implicated in the development of the vertebrate nervous system. Its product pp60c-src is a tyrosine-specific protein kinase that is expressed in two phases of neural development. An activated form of the pp60c-src is highly enriched in the membrane of nerve growth cones and in the proximal neuritic shaft of differentiating neurons, as shown in brain and retina. A possible role for pp60c-src in neuronal process extension is suggested that may involve cell-substratum adhesion or motility.
Department of Biochemistry, University of North Carolina School of Medicine, Chapel Hill 27515.
P F
PF
Maness
C G
CG
Shores
M
M
Ignelzi
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation; D005333:Fetus / Q000166:cytology / Q000378:metabolism; D006651:Histocytochemistry; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016392:Proto-Oncogene Proteins pp60(c-src); D012160:Retina / Q000166:cytology / Q000378:metabolism*
D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)