The effect of pimobendan on myocardial mechanical function and metabolism in dogs: comparison with dobutamine.
The effect of pimobendan, a newly developed cardiotonic agent, on myocardial mechanical function and energy metabolism has been examined in the dog heart, and compared with that of dobutamine. Either saline, vehicle for pimobendan, dobutamine (0.3 and 1 microgram kg-1), or pimobendan (0.3 and 1 mg kg-1) was injected intravenously. Dobutamine and pimobendan both increased the first derivative of left ventricular pressure and percent segment shortening, indicating their positive inotropic action. After 2 min of dobutamine injection, or after 20 min of pimobendan injection, the myocardium was removed, and used for determination of the tissue levels of metabolites of energy and carbohydrate metabolism. In general, all metabolic parameters measured were not changed by either dobutamine or pimobendan injection. In animals with aortic constriction for 10 months, dobutamine and pimobendan injections did not alter the myocardial energy and carbohydrate metabolism. Although dobutamine and pimobendan increased the cardiac mechanical function, they did not disturb the myocardial energy and carbohydrate metabolism.
Department of Pharmacology, Asahikawa Medical College, Japan.
K
K
Ichihara
Y
Y
Abiko
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004280:Dobutamine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D007275:Injections, Intravenous; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D011724:Pyridazines / Q000494:pharmacology*
D000227:Adenine Nucleotides; D002316:Cardiotonic Agents; D011724:Pyridazines; C041648:pimobendan; D004280:Dobutamine