Sensitivity of CAPD/IPD peritonitis organisms to ciprofloxacin.
Studies have suggested that oral quinolones may be useful in the treatment of peritonitis in peritoneal dialysis. We undertook a study of organisms causing peritonitis in our IPD and CAPD populations to determine if these organisms would be susceptible in vitro to Cipro. We determined the minimal inhibitory concentrations (MIC) of 62 non-duplicate isolates from episodes of peritonitis to Cipro by standard broth microdilution. Serial dilutions were done with Cipro and MIC50 and MIC90 were determined. The isolates were as follows: S, epidermidis (17), S. aureus (14), coliforms (11), Pseudomonas (8), Enterococci (8), Diphtheroids (4). The MIC50 and MIC90 for each of the isolate groups and overall are shown below.
Department of Medicine, St. Paul's Hospital, Saskatoon, Sask.
G B
GB
Pylypchuk
J
J
Conly
J E
JE
Kappel
K
K
Stein
R
R
Rennie
D002939:Ciprofloxacin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D010538:Peritonitis / Q000209:etiology / Q000382:microbiology*
D002939:Ciprofloxacin