Effects of flutropium on experimental models of drug- and allergy-induced rhinitis in guinea pigs.
The effects of flutropium on histamine (Hist)-induced increase in intranasal pressure in non-sensitized guinea pigs and nasal mucosa capillary permeability in passively sensitized guinea pigs were investigated. Flutropium (0.3%), atropine (0.3%), diphenhydramine (0.01%) and cimetidine (0.1%) were directly inhaled into the nasal cavities by an ultrasonic nebulizer for 20 min, followed by inhalation of Hist (0.1%) for 10 min. Flutropium, atropine and diphenhydramine had an inhibitory action on the Hist-induced increase in intranasal pressure in guinea pigs. Cimetidine had no effect on this system. In passively sensitized guinea pigs (the challenge was performed 48 hr after sensitization), a 0.1-1.0 mg/kg injection of flutropium (i.v.) dose-dependently inhibited the allergic nasal mucosa capillary permeability. Atropine (10 mg/kg, i.v.) had no inhibitory action on this system. These results suggest that inhalation into the nasal cavities and i.v. injection of flutropium are effective in experimental models of drug- and allergy-induced rhinitis of the guinea pig.
Mizuno
H
H
Central Research Laboratories, SS Pharmaceutical Co., Ltd., Narita, Japan.
Kawamura
Y
Y
Iwase
N
N
Ohno
H
H
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001286:Atropine Derivatives / Q000494:pharmacology*; D002927:Cimetidine / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D004342:Drug Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D009296:Nasal Cavity / Q000187:drug effects / Q000502:physiology; D011312:Pressure; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000276:immunology
D001286:Atropine Derivatives; D006634:Histamine H1 Antagonists; D001285:Atropine; D002927:Cimetidine; D006632:Histamine; D004155:Diphenhydramine; C039778:flutropium bromide