In situ demonstration of immunological heterogeneity in vascular endothelial cells of renal cell carcinoma.
Phenotypic characteristics of endothelial cells of blood vessels in renal cell carcinoma were studied immunohistochemically. Vascular endothelial cells in different compartments expressed surface antigens heterogenously. Sinusoidal capillary endothelial cells adjacent to carcinoma cells shared antigens with a monocyte/macrophage subset (OKM5 +, HLA-DR +, interleukin-1 +), but were only faintly positive or absent for factor VIII/von Willebrand factor antigen. Endothelial cells of larger vessels in fibrous septa were OKM5-, HLA-DR +, interleukin-1 +, factor VIII/von Willebrand factor antigen +. Renal cell carcinoma cells expressed HLA-DR and HLA-ABC antigens. These findings suggest that renal cell carcinoma cells are surrounded by blood vessels containing effector cells for immune responses, and that they have a high-potency response to immunopotentiators.
Department of Urology, Nagoya University School of Medicine, Japan.
T
T
Kinjo
M
M
Takashi
K
K
Miyake
H
H
Nagura
D000943:Antigens, Differentiation / Q000032:analysis; D018955:CD36 Antigens; D002196:Capillaries / Q000276:immunology; D002292:Carcinoma, Renal Cell / Q000098:blood supply / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000032:analysis; D007680:Kidney Neoplasms / Q000098:blood supply / Q000276:immunology*; D010641:Phenotype
D000943:Antigens, Differentiation; D018955:CD36 Antigens; D006680:HLA Antigens; D006684:HLA-DR Antigens; D007375:Interleukin-1