Embryonic stem cell grafting: the therapy of the future?
The grafting of mouse embryonic haemopoietic cells into deficient recipients is discussed. Donor cells can be obtained from post-implantation mouse embryos in vivo and used to treat X-irradiated or genetically anaemic recipients. The concept of grafting embryonic haemopoietic cells into normal, untreated recipients is also described. Preimplantation mouse blastocysts grown in vitro for 3-4 days can also be used as a source of donor cells. The haematological and immunological aspects of embryonic cell grafting are discussed, followed by a description of current xenotransplantation experiments, including rat into mouse and human into mouse. The review concludes with a discussion of the application of embryonic cell grafting to other tissues and a look into the possible future of this technique.
Hollands
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Amerlite Diagnostics Ltd, Green End, Aylesbury, Bucks, UK.
D000740:Anemia / Q000628:therapy; D000818:Animals; D016380:Brain Tissue Transplantation; D016332:Fetal Tissue Transplantation / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016381:Islets of Langerhans Transplantation; D051379:Mice; D016035:Pancreas Transplantation; D011828:Radiation Chimera; D051381:Rats; D014183:Transplantation, Heterologous