The use of 16,16-dimethyl-trans-delta 2 prostaglandin E1 methyl ester vaginal suppositories for management of missed abortion and fetal death.
The effect of vaginal administration of a PgE1 analogue to terminate missed abortion and fetal death in utero was evaluated in 62 women with gestation ranging from the 13th to the 37th week. Abortion occurred in 85.4% of women with missed abortion and in 86% of women with fetal death. In both groups, the mean induction time was less than 12 h. The incidence of side effects, primarily gastrointestinal symptoms, was infrequent.
Department of Obstetrics and Gynecology, Pisa University, Italy.
F
F
Fruzzetti
G B
GB
Melis
L
L
De Cecco
A R
AR
Genazzani
P
P
Fioretti
D000030:Abortion, Missed / Q000188:drug therapy*; D000282:Administration, Intravaginal; D005260:Female; D006801:Humans; D010570:Pessaries; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*
D011459:Prostaglandins E, Synthetic; C017244:16,16-dimethylprostaglandin E