Thy 1 expression in the brain of nude mice.
The expression and cell distribution of Thy 1 antigen was studied in the brain of both normal and athymic (nude) young adult mice of the BALB/c strain by immunochemistry. In nude animals Thy 1 fluorescence was less intense and less regularly distributed in the molecular layer of the cerebellum and hippocampus. Thy 1 content determined by ELISA was lower by 10-16% in the cerebellum and 20-25% in the olfactory bulbs of nude mice. The total wet weight of the brain was lower by 16% than in control animals; the deficit in body weight ranged from 34-45%. It is supposed that the changes in Thy 1 expression in nude animals are caused mainly by the underdevelopment of late developing brain regions due to thermoregulatory problems and other postnatal strains occurring in the mutants.
Mares
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V
Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
Holub
M
M
Ríha
I
I
Písa
P
P
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D001835:Body Weight; D001923:Brain Chemistry; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D018800:Thy-1 Antigens
D000954:Antigens, Surface; D018800:Thy-1 Antigens