[Osteocalcin in chronic alcoholism].
In order to investigate the mechanism by which the inorganic content of the bone is reduced in chronic alcoholism, the authors assayed osteocalcin in 60 chronic alcoholics. The level was significantly lower than in control subjects. There was no significant difference between levels in cirrhotics and in non-cirrhotic alcoholics. There was a negative correlation between osteocalcin and gamma GT levels. There was no correlation between osteocalcin and blood calcium, blood phosphorus, ALAT, ASAT, alkaline phosphatase, 5'-nucleotidase, albumin or bilirubin levels, or with the prothrombin time. These results suggest a direct impact of alcohol on the osteoblast.
Service de Rhumatologie, Centre Hospitalier Gilles de Corbeil.
J
J
Crouzet
A
A
Bochet-Cadiou
J
J
Denis
C
C
Brossard
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000097:blood*; D005260:Female; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D005723:gamma-Glutamyltransferase / Q000097:blood
D015675:Osteocalcin; D005723:gamma-Glutamyltransferase
L'ostéocalcine chez l'alcoolique chronique.