Murine IL-4 antagonizes the protective effects of IFN on virus-mediated lysis of murine L929 fibroblast cells.
IFN-alpha, -beta, and -gamma protect murine fibroblasts from lysis by vesicular stomatitis virus. In this report we show that culture supernatants derived from a Th cell clone of the TH2-type completely block the protective effects of the IFN. The active component in inhibiting IFN is identified to be IL-4. rIL-4 has similar effects as the T cell supernatant.
Institut für klinische Mikrobiologie der Universität, Erlangen-Nürnberg, FRG.
M
M
Lohoff
E
E
Marsig
M
M
Röllinghoff
D000818:Animals; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000037:antagonists & inhibitors; D007371:Interferon-gamma / Q000037:antagonists & inhibitors; D007372:Interferons / Q000037:antagonists & inhibitors*; D015847:Interleukin-4 / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D011994:Recombinant Proteins; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*; D014721:Vesicular stomatitis Indiana virus / Q000472:pathogenicity; D014762:Viral Interference / Q000187:drug effects*
D007370:Interferon Type I; D011994:Recombinant Proteins; D015847:Interleukin-4; D007371:Interferon-gamma; D007372:Interferons