Transient cerebral ischemia induces changes in SRIF mRNA in the fascia dentata.
A transient cerebral ischemia produced in rats by 4-vessel occlusion, produces with a delay of 24 h a fall in the number of somatostatin-containing neurons. In the present study we show that this loss is preceded by a loss of somatostatin mRNA that starts as soon as 30 min after the anoxic episode. By 24 h of revascularization the surviving somatostatinergic hilar cells present a transient recovery of hybridization signal. This effect could be related to a previously reported increase in intracellular calcium.
INSERM U 29, Paris, France.
A
A
Represa
V
V
Crépel
Y
Y
Ben-Ari
D000818:Animals; D001483:Base Sequence; D006624:Hippocampus / Q000473:pathology / Q000502:physiology / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008969:Molecular Sequence Data; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D015345:Oligonucleotide Probes; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013004:Somatostatin / Q000235:genetics*; D013997:Time Factors
D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D013004:Somatostatin