Florid reactive lymphoid hyperplasia of the terminal ileum in adults: a condition bearing a close resemblance to low-grade malignant lymphoma.
Five cases of florid lymphoid hyperplasia of the ileocaecal region are described. This condition is characterized by large reactive germinal centres and a diffuse infiltrate of lymphoid cells and eosinophils which extends through the muscularis propria. There is a close resemblance to low-grade malignant lymphoma from which it can be distinguished only by the use of immunocytochemistry for light-chains. Using this technique it should be possible to classify all such lymphoid proliferations as either reactive or neoplastic and to eliminate ambiguous labels like pseudolymphoma.
Rubin
A
A
Department of Histopathology, University College and Middlesex School of Medicine, London, UK.
Isaacson
P G
PG
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007077:Ileal Diseases / Q000473:pathology*; D007078:Ileal Neoplasms / Q000473:pathology*; D007082:Ileum / Q000473:pathology; D007150:Immunohistochemistry; D008206:Lymphatic Diseases / Q000473:pathology*; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling