Polyamines and long-term disuse of rat parotid glands.
A decrease in nerve reflex activation for 7-14 days, induced by a liquid diet, caused the rat parotid gland to lose weight, involving reduction in both cell size and number. In the atrophied glands, the activity of ornithine decarboxylase, the key enzyme in polyamine formation, and the levels of the polyamines putrescine, spermidine and spermine were found to be lowered. The present results are compatible with a role for polyamines in cellular growth.
Department of Physiology and Biophysics, University of Lund, Sweden.
B O
BO
Nilsson
E
E
Rosengren
J
J
Ekström
D000818:Animals; D004247:DNA / Q000737:chemistry; D005526:Food, Formulated / Q000009:adverse effects; D006801:Humans; D009929:Organ Size; D009955:Ornithine Decarboxylase / Q000737:chemistry; D010306:Parotid Gland / Q000033:anatomy & histology / Q000378:metabolism*; D011073:Polyamines / Q000737:chemistry*; D011700:Putrescine / Q000096:biosynthesis; D012313:RNA / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D013095:Spermidine / Q000096:biosynthesis; D013096:Spermine / Q000096:biosynthesis
D011073:Polyamines; D013096:Spermine; D012313:RNA; D004247:DNA; D009955:Ornithine Decarboxylase; D013095:Spermidine; D011700:Putrescine