[Experimental and epidemiological studies on the interrelationship of thiocyanate and thyroid function].
The testing of a SCN- dose (32 mg NaSCN/kg oral 21 d long) which is about 100 fold above the alimentary SCN(-)-uptake on guinea pig has shown neither histologic/morphometrical nor clinical clue to thyrostatic effect. In 6 regions of the GDR (1,349 persons) has not been secured epidemiologically any relationship between SCN- serum level as well as SCN- urine level and goiter. The partly in the tendency low increase of SCN- level by patients with bland goiter was always under the levels of smokers without goiter, exceeded indeed the threshold of significance in the area of Werdau. In the industrial agglomeration areas the I(-)-SCN(-)-quotient at the most unfavourable cases ran to 3.5 (Halle, smoker, struma), was consequently close to the critical level of the goiter risk.
Institut für Allgemeine und Kommunale Hygiene, der Ernst-Moritz-Arndt-Universität, Greifswald.
A
A
Kramer
W
W
Meng
D
D
Reinwein
W
W
Weuffen
H
H
Below
U
U
Ermisch
W D
WD
Jülich
S
S
Koch
R
R
Kellner
S
S
Meng
D000368:Aged; D000818:Animals; D013956:Antithyroid Agents / Q000633:toxicity*; D004812:Epidemiologic Methods; D005260:Female; D005859:Germany, East / Q000453:epidemiology; D006042:Goiter / Q000139:chemically induced*; D006043:Goiter, Endemic / Q000139:chemically induced / Q000453:epidemiology; D006168:Guinea Pigs; D006801:Humans; D007231:Infant, Newborn; D008875:Middle Aged; D011247:Pregnancy; D012307:Risk Factors; D013861:Thiocyanates / Q000009:adverse effects / Q000633:toxicity*
D013956:Antithyroid Agents; D013861:Thiocyanates
Experimentelle und epidemiologische Untersuchungen zu Wechselbeziehungen von Thiocyanat und Schilddrüsenfunktion.