Primary pulmonary alpha-fetoprotein-producing malignant germ cell tumor.
We are reporting the clinical and pathologic features of a primary, pulmonary, malignant germ cell tumor associated with a marked elevation of serum alpha-fetoprotein (38,427 ng/mL) and lactate dehydrogenase activity (756 U/L), in a 26-year-old female. This controversial, rare neoplasm has not been extensively discussed in the pathology literature. We emphasize the clinical importance of establishing this diagnosis in view of the favorable response to chemotherapy shown by malignant germ cell tumors.
Hunter
S
S
Department of Anatomic Pathology, Emory University School of Medicine, Atlanta, GA.
Hewan-Lowe
K
K
Costa
M J
MJ
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000378:metabolism; D002864:Chromogranins / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D008562:Membrane Glycoproteins / Q000378:metabolism; D008649:Mesonephroma / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D018396:Mucin-1; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D009418:S100 Proteins / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism*
D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D002864:Chromogranins; D008562:Membrane Glycoproteins; D018396:Mucin-1; D009418:S100 Proteins; D000509:alpha-Fetoproteins; D007633:Keratins; D007770:L-Lactate Dehydrogenase; D000469:Alkaline Phosphatase