The structure of gramicidin A in dimethylsulfoxide/acetone.
It has been demonstrated by two-dimensional NMR cross-relaxation spectroscopy that gramicidin A exists in dimethylsulfoxide/acetone solution in random coil form. This contradicts earlier conclusions by Hawkes et al. [Hawkes, G. E., Lian, L. Y., Randall, E. W., Sales, K. D. & Curzon, E. H. (1987) Eur. J. Biochem. 166, 437-445] that were based on the interpretation of vicinal proton coupling constants.
Roux
B
B
Department of Chemistry, Harvard University, Cambridge.
Brüschweiler
R
R
Ernst
R R
RR
D000096:Acetone; D004121:Dimethyl Sulfoxide; D006096:Gramicidin; D009682:Magnetic Resonance Spectroscopy; D011487:Protein Conformation; D012997:Solvents
D012997:Solvents; D000096:Acetone; D006096:Gramicidin; D004121:Dimethyl Sulfoxide