Arylsulfatase A in serum from patients with cancer of various organs.
Arylsulfatase A was radioimmunoassayed in serum specimens of 96 healthy volunteers and 368 patients with histopathologically confirmed cancer of gastrointestinal tract, breast, lung, central nervous system, kidney and woman genital tract. Sensitivity, specificity and predictive value of the test were 43%, 82% and 90%, respectively, which means that a positive test is significant for diagnosis of cancer regardless of its localization. More detailed statistical analysis of the results indicates that determination of the serum concentration of arylsulfatase A might be helpful in the diagnosis of lung (59% sensitivity, 82% specificity) and central nervous system cancer (60% sensitivity, 82% specificity). Further studies should also be continued in respect to renal and women genital tract cancers for which the results of the test, although promising, are at present not conclusive due to the small numbers of examined cases. Particularly, determination of serum arylsulfatase A in case of endometrial cancer seems to be of diagnostic value. Arylsulfatase A concentration in serum with a lower than 40% sensitivity of the test cannot be considered as a valuable tumor indicator in the case of cancer of breast and gastrointestinal tract, although 80% predictive value of the test for the latter group of tumors is quite high and perhaps merits additional consideration.
Institute of Medical Biochemistry, Medical Academy, Kraków, Poland.
P
P
Laidler
D
D
Kowalski
J
J
Silberring
D000328:Adult; D016543:Central Nervous System Neoplasms / Q000201:enzymology; D002553:Cerebroside-Sulfatase / Q000097:blood*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000201:enzymology; D005833:Genital Neoplasms, Female / Q000201:enzymology; D006801:Humans; D007680:Kidney Neoplasms / Q000201:enzymology; D008175:Lung Neoplasms / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000201:enzymology*; D012016:Reference Values; D013223:Statistics as Topic
D002553:Cerebroside-Sulfatase