[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)].
A group of 250 patients with endogenous depression was studied. Amitriptyline proved to be the most effective drug (51% positive responses) followed by noxiptilin (50%), imipramine (42%), dibenzepin (43%). Clomipramine, desipramine, and nomifensine appeared to be the least effective. Demographic or clinical factors such as age, sex, type of affective illness, severity of depressive syndrome or its particular symptoms (depression, fear, anxiety, psychomotor impairment or biological rhythm alteration) did not show any potential for prediction of the treatment outcome. Worse therapeutic results were observed in patients who had already been given antidepressant treatment for the current depressive cycle before the assessment.
II Kliniki Psychiatrycznej Instytutu Psychiatrii i Neurologii.
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Beresewicz
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Bidzińska
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Koszewska
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Puzyński
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D003891:Desipramine / Q000627:therapeutic use; D003984:Dibenzazepines / Q000627:therapeutic use; D003986:Dibenzocycloheptenes / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009627:Nomifensine / Q000627:therapeutic use; D012074:Remission Induction
D000929:Antidepressive Agents, Tricyclic; D003984:Dibenzazepines; D003986:Dibenzocycloheptenes; D000639:Amitriptyline; D009627:Nomifensine; C100240:noxiptilin; D002997:Clomipramine; D007099:Imipramine; D003891:Desipramine
Wyniki stosowania trójpierścieniowych leków przeciwdepresyjnych w terapii depresji endogennej (analiza porównawcza 7 leków).