[New prospects in the therapeutic use of somatostatin and its derivatives].
The discovery and subsequent clinical application of somatostatine, a polypeptide neurohormone of 14 amino acids, and of its analogs, opens a novel chapter of neuroendocrinology that is still in full evolution and to a large extent unknown. The isolation of an octapeptide, a selective somatostatine analog, permits to prolong its action, in fact it has a halflife of about 140 min in old subjects and about 100 min. in the young. Thanks to its excellent tolerability, the synthetic hormone can be usefully applied in the treatment of acromegaly, gigantism and hypersomatotropinemic conditions in general, and even in other clinical branches, such as treatment of esophageal hemorrhage due to the rupture of varices in liver cirrhosis or to erosion of gastric blood vessels in patients suffering from peptic ulcer disease.
Simeoni
A
A
II Clinica Medica, Università degli Studi di Roma La Sapienza.
Agostino
A
A
Vecci
E
E
Iacobelli
P
P
Vitellone
P
P
Iacobelli
A
A
D000172:Acromegaly / Q000188:drug therapy; D004361:Drug Tolerance; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006801:Humans; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D013004:Somatostatin
Nuove prospettive nell'uso terapeutico della somatostatina e dei suoi derivati.