[Cough reflex in respiratory disease].
Imbalance between peptides such as substance P and bradykinin, and related enzymes degrading these peptides may cause the development of cough in various pathological conditions. On the other hand, lack of cough reflex may cause aspiration pneumonia. Down and up regulation by peptides may be useful for treatment of cough and prevention of aspiration pneumonia.
Sekizawa
K
K
Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan.
Sasaki
H
H
D000368:Aged; D001920:Bradykinin / Q000378:metabolism; D003371:Cough / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011015:Pneumonia, Aspiration / Q000517:prevention & control; D012018:Reflex; D012141:Respiratory Tract Infections / Q000503:physiopathology*; D013373:Substance P / Q000378:metabolism
D013373:Substance P; D001920:Bradykinin