[Effects of pentagastrin and somatostatin on duodenal motility in chronic experiments].
Electromyography of the duodenums was performed in dogs, using two bipolar electrodes placed 5 and 10 cm aborally of the pylorus on the serosa of the duodenums. 10 days after implantation and 24 hours after the last meal the duodenal motility was registered in 9 bastard dogs for 5 hours. Pentagastrin, given as a 1-hour intravenous infusion, changed the interdigestive motility to an irregular (postprandial) pattern, which continued up to the end of measurement or was followed by a prolonged phase III with return to cyclic activity. Infusion of somatostatin for 1 hour interrupted the interdigestive motility leading to a prolonged phase I pattern and to partial discoordination. After the end of infusion phase III motility returning to cyclic activity or irregular activity were registered. A standard relaparotomy 10 days after implantation was performed in 3 dogs. Up to the second day of the postoperative period interdigestive cycles of duodenal motility were not obtained.
Petzold
A
A
Klinik für Chirurgie, Universität Leipzig.
Hammer
J
J
Walther
J
J
Keitel
R
R
Junhold
V
V
D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000187:drug effects / Q000502:physiology*; D004567:Electrodes, Implanted; D004576:Electromyography; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007263:Infusions, Parenteral; D010418:Pentagastrin / Q000008:administration & dosage / Q000494:pharmacology*; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D013004:Somatostatin; D010418:Pentagastrin
Untersuchungen zur Wirkung von Pentagastrin und Somatostatin auf die Duodenalmotilität im chronischen Versuch.