Granular cell tumour of the appendix in a patient irradiated for a rectal carcinoma.
We report on a 47-year-old man with a granular cell tumour of the appendix, discovered incidentally during surgery for a rectal adenocarcinoma that had been irradiated preoperatively. A detailed immunocytochemical analysis revealed positivity for S-100 and neuron-specific enolase (NSE). Electron microscopically, the cytoplasm of the tumour cells contained numerous pleomorphic lysosomes. In the appendix tissue adjacent to the tumour a neuroma and the histological features of radiation injury were present. Our findings suggest that this granular cell tumour may have originated from a pre-existing appendix neuroma which underwent granular degeneration, possibly as a result of radiation.
Department of Pathology, Academic Hospital, Free University of Brussels, Belgium.
M
M
Pipeleers-Marichal
A
A
Goossens
B
B
De Waele
G
G
Klöppel
D001063:Appendiceal Neoplasms / Q000378:metabolism / Q000473:pathology*; D002277:Carcinoma / Q000532:radiotherapy*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012004:Rectal Neoplasms / Q000532:radiotherapy*; D009418:S100 Proteins / Q000378:metabolism; D013194:Staining and Labeling
D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase