[Adverse effects of ulcer drugs before and after release of cimetidine, ranitidine and sucralfate for over-the-counter sale].
During the period from the first marketing of cimetidine in 1977 and until 31 March 1990, the Danish Committee on Adverse Drug Reactions received 494 reports concerning a total of 612 suspected adverse reactions to peptic ulcer drugs (ATC group A02B). Out of these, adverse reactions to H2-receptor antagonists constituted 90%. The investigation confirms the fact that safe drugs are concerned which only rarely cause serious adverse reactions. During the first year after cimetidine, ranitidine and sucralfate became available over-the-counter (27 March 1989-31 March 1990), only one report about side effects caused by cimetidine sold over-the-counter was received. This corresponds to what might be anticipated from the usage figures, if availability over-the-counter does not result in particular adverse reaction problems. Decrease in the number of reports, alterations in the pattern of adverse reactions and under-reporting of known adverse reactions render employment of data from voluntary reports difficult.
Sundhedsstyrelsens Bivirkningsnaevn, København.
M
M
Andersen
J S
JS
Schou
D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D002927:Cimetidine / Q000009:adverse effects; D003718:Denmark / Q000453:epidemiology; D006635:Histamine H2 Antagonists / Q000009:adverse effects; D006801:Humans; D004366:Nonprescription Drugs / Q000009:adverse effects*; D010437:Peptic Ulcer / Q000188:drug therapy*; D011899:Ranitidine / Q000009:adverse effects; D013392:Sucralfate / Q000009:adverse effects
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D004366:Nonprescription Drugs; D013392:Sucralfate; D002927:Cimetidine; D011899:Ranitidine
Bivirkninger af ulcusmedicin før og efter overførsel af cimetidin, ranitidin og sukralfat til håndkøb.