Hyperamylasemia associated with progression of a serous surface papillary carcinoma.
A 60-year-old white woman had a bilateral salpingo-oophorectomy, hysterectomy, and omentectomy for serous surface papillary carcinoma. Combination chemotherapy consisting of cisplatin, doxorubicin, and cyclophosphamide was given for 1 year, but was followed by relapse 4 months after completion. This relapse was associated with hyperamylasemia ranging from 2400 IU/liter in the early phase of relapse to 5800 IU/liter in the preterminal phase. While hyperamylasemia has been previously described in serous ovarian cystadenocarcinoma, to our knowledge this is the first report in a patient with serous surface papillary carcinoma. This marker may help in distinguishing the latter from malignant mesothelioma of the peritoneum since this is often an extremely difficult differential diagnosis.
O'Riordan
T
T
St. James's Hospital, Dublin, Ireland.
Gaffney
E
E
Tormey
V
V
Daly
P
P
D000681:Amylases / Q000097:blood*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000175:diagnosis / Q000201:enzymology*; D008854:Microscopy, Electron; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology
D000681:Amylases