[Use of cytostatics in polymer-drug complexes in the treatment of malignant neoplasms of the maxilla].
The authors analyze the efficacy of antitumor drugs deposited with cyanoacrylate adhesive solution in therapy of Stages III-IV maxillary tumors. Immediate and late results of therapy with these compositions of 21 patients evidence that such treatment is not associated with the wound or general toxic complications and that wounds may be managed without tampons. Deposition of the drug and its regulated elimination from the composition helps create a high concentration of the agent at the operation site where the tumor elements remained after surgery; this permits expecting better late results.
Rusakov
I G
IG
Ol'shanskiĭ
V O
VO
Savizhkov
A M
AM
Kislichko
A G
AG
Akimova
A Ia
AIa
D000328:Adult; D000368:Aged; D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage* / Q000031:analogs & derivatives; D002360:Carubicin / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D003487:Cyanoacrylates / Q000008:administration & dosage*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D004343:Drug Implants; D005260:Female; D006801:Humans; D008297:Male; D008437:Maxilla / Q000187:drug effects / Q000601:surgery*; D008441:Maxillary Neoplasms / Q000601:surgery*; D008875:Middle Aged; D011182:Postoperative Care; D051381:Rats
D003487:Cyanoacrylates; D004343:Drug Implants; D001761:Bleomycin; C025703:bleomycetin; D002360:Carubicin; D003630:Daunorubicin
Primenenie tsitostatikov v sostave polimerlekarstvennykh kompleksov pri lechenii zlokachestvennykh novoobrazovaniĭ verkhneĭ cheliusti.