Lack of neuroleptic-like activity of l-fenfluramine.
Rats were trained to differentiate between the dopaminergically mediated discriminative stimuli produced by intraperitoneal administration of 4.8 mg/kg cathine and its vehicle. Once trained, three doses of l-fenfluramine (1.0, 2.0 and 2.5 mg/kg) were administered to determine if this agent would produce cathine-appropriate discriminative performance. All doses of l-fenfluramine were observed to produce vehicle-like responding. The 2.0 mg/kg dose of l-fenfluramine as well as 3.0 mg/kg chlorpromazine were administered in separate experiments prior to either cathine or vehicle. Chlorpromazine attenuated cathine-lever responding after cathine administration but did not affect vehicle responding. In contrast, l-fenfluramine had no effect upon cathine discrimination. The results indicate that l-fenfluramine shares neither agonist nor antagonist activity in the dopamine-mediated discriminative performance produced by cathine.
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
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MD
Schechter
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003463:Cues; D004192:Discrimination, Psychological / Q000187:drug effects; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D005277:Fenfluramine / Q000494:pharmacology*; D008297:Male; D010665:Phenylpropanolamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D014150:Antipsychotic Agents; D015259:Dopamine Agents; D018492:Dopamine Antagonists; C005331:norpseudoephedrine; D005277:Fenfluramine; D010665:Phenylpropanolamine