The role of the adrenoceptors in the activation of the hypothalamic-pituitary-testicular complex of mice induced by the presence of a female.
A study was made of the role of the adrenergic processes in the activation of the testes endocrine function in male mice of CBA/Lac and A/He strains after their sexual arousal induced by the presence of a sexually receptive female without any tactile contact with a male. The alpha-adrenoceptor blocker phentolamine and the alpha 1-adrenoceptor antagonist prazosin inhibited an increase of testosterone level in the peripheral blood plasma caused by the presence of a female. In contrast, antagonist of the beta-adrenoceptor propranolol and beta 2-adrenoceptor blocker ICI-118.551 significantly intensified the stimulating effect of the female presence on plasma testosterone level. The expression of effects of the adrenoceptor antagonists on the plasma testosterone level depended on a male genotype. At the same time, pretreatment of males with yohimbine, an antagonist of the alpha 2-adrenoceptors, or with metoprolol, a beta 1-adrenoceptor blocker, did not influence the activating effect of a female on the plasma level of testosterone. A conclusion was drawn that during sexual arousal in male mice caused by the presence of a receptive female, the stimulatory effects on the hypothalamic-pituitary-testicular complex were produced through the alpha 1-adrenoceptors, and the inhibitory effects were realized through the beta 2-adrenoceptors.
Institute of Cytology and Genetics, Siberian Branch, Acad, Sci. of USSR, Novosibirsk.
E V
EV
Naumenko
T G
TG
Amstislavskaja
A V
AV
Osadchuk
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D010646:Phentolamine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011863:Radioimmunoassay; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000096:biosynthesis; D015016:Yohimbine / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; D011941:Receptors, Adrenergic; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D015016:Yohimbine; D013739:Testosterone; C026777:ICI 118551; D011433:Propranolol; D008790:Metoprolol; D011224:Prazosin; D010646:Phentolamine