Intravenous magnesium supplementation during cisdiammine-dichloroplatinum administration prevents hypomagnesemia.
Ten patients with disseminated testicular cancer were studied during 3 cycles of 20 mg/m2/day x 5 d CDDP combined with bleomycin and vinblastine or etoposide. Five of the patients (= group A) received 0.4 mmol KCl/kg/day and 0.3 mmol MgCl2/kg/day; the other five (= group B) received only KCl intravenously during the CDDP infusions. In group A no decrease of serum and red blood cell Mg concentration was noted. In group B the serum Mg concentration decreased from 0.84 +/- 0.04 mmol/l to 0.57 +/- 0.10 (p less than 0.001) on day 47, to 0.64 +/- 0.08 (p less than 0.005) on day 50 and to 0.72 +/- 0.02 (p less than 0.05) on day 57. The Mg concentration in the red blood cells decreased, but not significantly in group B. Furthermore, the fractional calcium excretion in group B was significantly lower than in group A during the CDDP infusions.
Department of Medicine, St. Radboud University Hospital, Nijmegen, The Netherlands.
P M
PM
Netten
P H
PH
de Mulder
A G
AG
Theeuwes
J L
JL
Willems
B E
BE
Kohler
D T
DT
Wagener
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000493:pharmacokinetics; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007684:Kidney Tubules / Q000502:physiology; D008274:Magnesium / Q000008:administration & dosage* / Q000097:blood; D008275:Magnesium Deficiency / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D014747:Vinblastine / Q000008:administration & dosage
D009944:Organoplatinum Compounds; D001761:Bleomycin; C055423:didimethylsulfoxide dichloroplatinum(II); D014747:Vinblastine; D005047:Etoposide; D012964:Sodium; D003404:Creatinine; D008274:Magnesium; D011188:Potassium; D002118:Calcium