Study on pruritus in hemodialysis patients and the antipruritic effect of neurotropin: plasma levels of substance P, somatostatin, IgE, PTH and histamine.
It has been reported that Neurotropin can markedly improve pruritus in patients undergoing hemodialysis (HD). In order to elucidate the probable causes of pruritus and the antipruritic effect of Neurotropin, various biochemical parameters in the plasma of patients before and during HD were investigated. Forty-three patients undergoing HD were divided into three groups. Eighteen patients had suffered no episode of pruritus (group A), 17 patients had on-going pruritus (group B) and the remaining 8 patients had experienced improvement of pruritus following Neurotropin treatment (group C). The mean concentration of substance P was in only B group significantly increased with HD only in B group, indicating that substance P could be one of the causes of pruritus in patients undergoing HD. Neurotropin appears to exert its antipruritic effect by lowering the level of substance P. The change in parathyroid hormone (PTH) level during HD was not significant in any of the groups, but the mean concentration of PTH in group B was higher than that of group A, indicating that PTH may also be one of the causes of pruritus.
Department of Biochemistry, Nippon Zoki Pharmaceutical Co. Ltd., Hyogo, Japan.
H
H
Kaku
Y
Y
Fujita
H
H
Yago
F
F
Naka
H
H
Kawakubo
K
K
Nakano
K
K
Nishikawa
S
S
Suehiro
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011134:Polysaccharides / Q000627:therapeutic use*; D011537:Pruritus / Q000209:etiology / Q000517:prevention & control*; D006435:Renal Dialysis; D013004:Somatostatin / Q000097:blood; D013373:Substance P / Q000097:blood
D000276:Adjuvants, Immunologic; D010281:Parathyroid Hormone; D011134:Polysaccharides; D013373:Substance P; D007073:Immunoglobulin E; D013004:Somatostatin; C010491:neurotropin; D006632:Histamine