Lymphomatoid papulosis with antigen deletion and clonal rearrangement in a 4-year-old boy.
Lymphomatoid papulosis (LyP) is rarely seen in children. We report a case of LyP in a 4-year-old boy in whom immunopathologic studies demonstrated T cell antigen deletions. In contrast to all but two previous reports, a T suppressor (CD-8) phenotype was predominant. Southern blot analysis of DNA isolated from a typical skin lesion indicated a clonal rearrangement of the T cell receptor beta gene. Because of a 10% frequency of malignant lymphomas in patients with LyP, long-term observation is crucial, especially in children. We recommend routine clonal rearrangement studies for aid in diagnosis and follow-up, and as possible prognostic indicators in children with this condition.
Hellman
J
J
Department of Dermatology, Mount Sinai School of Medicine, New York, New York.
Phelps
R G
RG
Baral
J
J
Fasy
T M
TM
Ahern
C M
CM
Strauchen
J A
JA
D015703:Antigens, CD / Q000276:immunology; D015139:Blotting, Southern; D002648:Child; D002675:Child, Preschool; D002999:Clone Cells; D000939:Epitopes / Q000276:immunology*; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007223:Infant; D008297:Male; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012871:Skin Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000939:Epitopes; D011948:Receptors, Antigen, T-Cell