A syndrome resembling feline dysautonomia (Key-Gaskell syndrome) in a dog.
Dysautonomia, or autonomic nervous system dysfunction, was diagnosed in a 1-year-old dog. Clinical signs of disease included diarrhea, vomiting, prolapse of nictitating membranes, and urinary incontinence. Bilateral keratoconjunctivitis sicca, xerostomia, and decreased anal sphincter tone were also observed. On the basis of response to atropine, results of intradermal histamine testing and gastric motility studies, and ocular response to parasympathomimetics and sympathomimetics (direct and indirect acting), autonomic nervous system function was determined to be abnormal. Treatment with metoclopramide hydrochloride and bethanechol chloride resulted in improved attitude, appetite, Schirmer tear test response, and decrease in frequency of vomiting within 24 hours. Bladder function and anal tone improved within 3 weeks.
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
L A
LA
Wise
M R
MR
Lappin
D000818:Animals; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000662:veterinary*; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy; D004285:Dogs; D005260:Female; D008787:Metoclopramide / Q000627:therapeutic use; D013577:Syndrome
D001626:Bethanechol Compounds; D018723:Bethanechol; D008787:Metoclopramide