Increased angiogenesis in diabetes.
Rats with streptozotocin-induced diabetes mellitus showed a 3.4-4.5 times increased angiogenic response following mast-cell activation in situ as compared with age-matched normal controls. The test tissue used was the mesenteric window, which we have previously exploited as a quantitative angiogenesis assay. In the present study two independent techniques for quantifying the angiogenic response showed essentially the same result. The finding of a pathologically increased angiogenic reaction in the diabetic animals is noteworthy since some of the most harmful complications of diabetes in man relate to proliferative vascular lesions.
Norrby
K
K
Department of Pathology, Gothenburg University, Sahlgren's Hospital, Sweden.
Jakobsson
A
A
Simonsen
M
M
Sörbo
J
J
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D008407:Mast Cells / Q000502:physiology; D008643:Mesentery / Q000098:blood supply; D009389:Neovascularization, Pathologic; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose