Peripheral benzodiazepines potentiate the effect of adenosine in rat vas deferens.
Ro 5-4864, diazepam, clonazepam and PK 11195 inhibit the responses of rat was deferens following electrical stimulation in the rank order Ro 5-4864 greater than PK 11195 = diazepam greater than clonazepam. The adenosine-inhibited electrically-induced response was potentiated by Ro 5-4864 or diazepam, but not by clonazepam or PK 11195. This potentiation is due to an inhibition of the adenosine uptake system.
Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Spain.
E
E
Escubedo
J
J
Camarasa
M
M
Pallas
T
T
Adzet
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D004357:Drug Synergism; D004558:Electric Stimulation; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000187:drug effects
D001570:Benzodiazepinones; D007546:Isoquinolines; D001569:Benzodiazepines; C028513:4'-chlorodiazepam; D000241:Adenosine; C037850:PK 11195