Computer analysis of antigenic domains and RGD-like sequences (RGWG) in the E glycoprotein of flaviviruses: an approach to vaccine development.
Antigenic domains and RGD-like sequences in the E glycoprotein of the flaviviruses Japanese encephalitis virus, yellow fever virus, West Nile virus, dengue type 4 virus, and tick-borne encephalitis virus were analyzed by computer programs that provide information on the physical properties of the polypeptides. The use of computer programs for the development of vaccines based on the synthesis of antigenic peptides is discussed. Synthetic viral peptides are proposed to be used for topical application so as to interfere with the virus-cell interaction. Viral peptides with antigenic epitopes to protect against dengue virus infection without enhancing pathogenesis may also be developed on the basis of the computer analysis.
Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
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Becker
D000595:Amino Acid Sequence; D003201:Computers; D000939:Epitopes / Q000032:analysis*; D005416:Flavivirus / Q000276:immunology*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012689:Sequence Homology, Nucleic Acid; D014759:Viral Envelope Proteins / Q000032:analysis* / Q000276:immunology
D000939:Epitopes; D014759:Viral Envelope Proteins