Interferon activity is not detected in blastocyst secretions and does not induce decidualization in mice.
Mouse trophoblast cells synthesized and secreted proteins during the peri-implantation period, some in the molecular size range of alpha interferons (IFN-alpha), known mediators of the maternal recognition of pregnancy in sheep and cows. However, conditioned media samples containing secreted proteins from Day-5 mouse blastocysts or from trophoblast outgrowths did not contain detectable levels of antiviral activity indicative of IFN. In addition, it was not possible to induce a decidual reaction in suitably sensitized uteri with intraluminal instillation of IFN-alpha. The results indicate that IFNs are probably not involved in the maternal recognition of pregnancy at the time of implantation in the mouse.
Baker
D J
DJ
Department of Anatomy, Wright State University School of Medicine Dayton, Ohio 45435.
Nieder
G L
GL
D000818:Animals; D003656:Decidua / Q000502:physiology*; D005260:Female; D007370:Interferon Type I / Q000494:pharmacology; D007372:Interferons / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011506:Proteins / Q000378:metabolism; D014327:Trophoblasts / Q000166:cytology / Q000502:physiology*; D014599:Uterus / Q000502:physiology
D007370:Interferon Type I; D011506:Proteins; D007372:Interferons