[Incidence of amplification of the C-erb B2/Her-2/neu gene in human breast cancer].
Activation of cellular proto-oncogenes can be detected in several human cancers. In the current study, alterations of C-erb B2 gene in primary human breast cancers were investigated. It was found to be amplified from 2 to 30 fold in 25% of the tumors. Correlations of gene amplification with several disease parameters was evaluated.
Laboratoire d'Immunologie, Institut Salah Azaïez, Tunis.
M
M
Sellami
M
M
Gamoudi
K
K
Krichen
A
A
Kharrat
K
K
Ben Romdhane
M
M
Maalej
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000737:chemistry / Q000235:genetics*; D001943:Breast Neoplasms / Q000737:chemistry / Q000453:epidemiology / Q000235:genetics*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000737:chemistry / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics*; D018719:Erb-b2 Receptor Tyrosine Kinases; D012307:Risk Factors; D014416:Tunisia / Q000453:epidemiology
D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases
Incidence de l'amplification du gène C-erb B2/Her-2/neu dans le cancer du sein humain.