Dipeptidyl peptidase IV in the human lung and spinocellular lung cancer.
The isoelectric point and proportions of soluble and membrane bound dipeptidyl peptidase IV (DPP-IV) in human lung and spinocellular lung cancer tissue were tested. It was found that soluble DPP-IV is relatively less frequent in the cancer than in normal lung tissue. We demonstrated multiple molecular forms of DPP-IV in normal and cancer lung tissues, differing probably not only in the degree of sialylation. DPP-IV from lung cancer tissue consists of more basic molecular forms than that from normal lung tissue. These results suggest that the molecular properties of DPP-IV in normal and cancerous lung tissues may be different.
Research Institute of Tuberculosis and Respiratory Diseases, Charles University, Faculty of Medicine, Prague.
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A
Sedo
E
E
Krepela
E
E
Kasafírek
J
J
Kraml
L
L
Kadlecová
D002294:Carcinoma, Squamous Cell / Q000201:enzymology*; D018819:Dipeptidyl Peptidase 4; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000032:analysis*; D006801:Humans; D007525:Isoelectric Focusing; D008168:Lung / Q000201:enzymology*; D008175:Lung Neoplasms / Q000201:enzymology*
D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; D018819:Dipeptidyl Peptidase 4