Indirect role of T cells in development of polioencephalitis and encephalomyelitis induced by encephalomyocarditis virus.
Infection of female BALB/c mice with encephalomyocarditis virus results in the development of a paralytic syndrome in 7 to 10 days postinoculation. Previous studies had suggested the involvement of an immune component in the development of central nervous system pathology. We have examined the effects of T-cell depletion on the development of polioencephalitis (neuronal necrosis and inflammation of the brain and brain stem) and the relative contribution of the CD4+ and CD8+ subsets following the establishment of viremia. We show that monoclonal antibody depletion of T cells is effective in the reduction of polioencephalitis when given prior to viral inoculation. However, administration of the antibodies 12 h or more after viral inoculation failed to alter the development of polioencephalitis or encephalomyelitis. We conclude that T cells are involved in the development of central nervous system disease during the initial stages of infection but are not responsible for the later progression of disease.
Department of Pathology, College of Medicine, University of Vermont, Burlington 05405.
D J
DJ
Topham
A
A
Adesina
M
M
Shenoy
J E
JE
Craighead
S
S
Sriram
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004679:Encephalomyelitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D004686:Encephalomyocarditis virus / Q000502:physiology*; D005260:Female; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011051:Poliomyelitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014766:Viremia / Q000150:complications / Q000473:pathology
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral