Myelin basic protein-specific T cells induce demyelinating experimental autoimmune encephalomyelitis in Buffalo rats.
This is the first description of acute demyelinating experimental autoimmune encephalomyelitis (EAE) induced in rats by myelin basic protein (BP)-specific T lymphocytes without the administration of demyelinating antibodies. BP-specific T cell lines were selected from inbred Buffalo-strain rats (Rt-1b) following techniques used to develop similar lines from Lewis rats (Rt-1l). Unlike those of Lewis rats, the spinal cords of Buffalo rats with T cell line-mediated EAE had prominent perivascular demyelination associated with mononuclear inflammation. Like Lewis rat lines. Buffalo rat BP-specific T cell lines transferred acute, non-relapsing EAE into syngeneic recipients, demonstrating that demyelination in passive acute EAE can occur without subsequent clinical relapses.
Neuroimmunology Research, VA Medical Center, Portland, OR 97201.
R E
RE
Jones
D N
DN
Bourdette
H
H
Offner
A A
AA
Vandenbark
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology*; D002460:Cell Line; D003711:Demyelinating Diseases / Q000209:etiology*; D004679:Encephalomyelitis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D016219:Immunotherapy, Adoptive; D004676:Myelin Basic Protein / Q000276:immunology*; D051381:Rats; D011915:Rats, Inbred BUF; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D004676:Myelin Basic Protein