The HLA-DRB6 locus defines an evolutionary supratypic group within the DRB family of genes.
A novel DRB gene member has recently been identified (DRB6). It defines a new supratypic group of HLA-DR alleles comprising the DR1-, DR2-, and DRw10-carrying haplotypes. The comparison of this gene either at the nucleotide or at the protein level with other HLA-DRB genes supports its inclusion in the DRB gene family and not in DPB or DQB gene families. Moreover, the construction of an evolutionary gene-tree shows that this gene is probably the eldest member of the DRB gene family. Contradictory expression results do not clarify whether or not DRB6 is a pseudogene.
Immunologia, Hospital 12 de Octubre, Madrid, Spain.
A
A
Corell
J M
JM
Martin-Villa
P
P
Morales
M D
MD
de Juan
J L
JL
Vicario
J
J
Martínez-Laso
P
P
Varela
A
A
Arnaiz-Villena
D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000097:blood / Q000235:genetics; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens / Q000235:genetics*; D059806:HLA-DR beta-Chains; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D012689:Sequence Homology, Nucleic Acid
D006684:HLA-DR Antigens; D059806:HLA-DR beta-Chains; C069699:HLA-DRB6 antigen; D004247:DNA