Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM1 membranous ganglioside.
To investigate structural changes in cell membranes of the Alzheimer-type dementia (ATD) brain, we immunostained for GM1 ganglioside which is a major component of the cell membrane. Our results have shown that astrocytic membranes and senile plaques (SPs) have the same immunoreactivity against the monoclonal anti-ganglioside GM1 antibody. Moreover, the astrocytic processes within the SPs were altered and their abnormal membranes seemed to contribute to the formation of SPs.
Department of Psychiatry, School of Medicine, Juntendo University, Tokyo, Japan.
N
N
Iwamoto
Y
Y
Suzuki
Y
Y
Makino
C
C
Haga
K
K
Kosaka
R
R
Iizuka
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001253:Astrocytes / Q000187:drug effects / Q000648:ultrastructure; D001921:Brain / Q000473:pathology*; D002462:Cell Membrane / Q000648:ultrastructure*; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D005677:G(M1) Ganglioside