Factor XIII-deficiency in the blood of venous leg ulcer patients.
Pericapillary fibrin cuffs are probably involved in the pathogenesis of venous leg ulcers. Factor XIII (Fibrin stabilizing factor) is of importance in wound healing. Its activity, which may affect ulceration, was found to be significantly reduced in the blood of venous leg ulcer patients and in post-phlebitic patients, compared with healthy controls.
Department of Dermatology, University of Freiburg, FRG.
W
W
Vanscheidt
K
K
Hasler
H
H
Wokalek
R
R
Niedner
E
E
Schöpf
D002908:Chronic Disease; D005176:Factor XIII / Q000032:analysis; D005177:Factor XIII Deficiency / Q000097:blood*; D005337:Fibrin / Q000032:analysis; D006801:Humans; D007871:Leg Ulcer / Q000097:blood; D011186:Postphlebitic Syndrome / Q000097:blood; D014647:Varicose Ulcer / Q000097:blood*; D014945:Wound Healing
D005337:Fibrin; D005176:Factor XIII