Studies of the pharmacokinetics and metabolism of 4-amino-propiophenone (PAPP) in rats, dogs and cynomolgus monkeys.
The pharmacokinetics and metabolism of 4-aminopropiophenone (PAPP), a cyanide antidote, have been studied in rats, dogs and cynomolgus monkeys using 14C-PAPP. Radiolabelled material was rapidly excreted in all three species, mainly in urine. In rats, PAPP was metabolized by N-acetylation, while in dogs, ring and aliphatic hydroxylation occurred. In monkeys, both N-acetylation and oxidation took place. In the latter pathway, PAPP was oxidized to p-aminobenzoic acid which underwent amino acid-conjugation to p-aminohippuric acid. In rat blood in vitro, the PAPP metabolites, p-aminobenzoic, p-aminohippuric and N-acetyl-p-aminobenzoic acid were only weak methaemoglobin producers.
Huntingdon Research Centre Ltd, Cambs, UK.
S G
SG
Wood
K
K
Fitzpatrick
J E
JE
Bright
R H
RH
Inns
T C
TC
Marrs
D000818:Animals; D002250:Carbon Radioisotopes; D004285:Dogs; D005260:Female; D008252:Macaca fascicularis; D008297:Male; D011427:Propiophenones / Q000493:pharmacokinetics* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D002250:Carbon Radioisotopes; D011427:Propiophenones; C029564:4-aminopropiophenone