Hydroxyethyl starch macromolecules reduce myocardial reperfusion injury.
We assessed the value of a fraction of hydroxyethyl starch (HES Pz) in reducing the myocardial reperfusion injury in a canine open-chest model in which 1 hour of left anterior descending coronary artery occlusion was followed by 24 hours of reperfusion. Three treatment infusions (5% of blood volume) were compared: Ringer's lactate, serum albumin, and HES Pz (70% of the macromolecules between 100,000 and 1,000,000 d). When compared with Ringer's lactate and albumin, HES Pz significantly reduced the ratio of 24-hour infarct size to pretreatment area at risk (3% vs 19% and 16%, respectively) and myocardial water content (0.5% vs 3% and 1%). Potassium content differences between injured and normal myocardium were significantly less in the infarct regions of animals receiving HES Pz. In the canine model, HES Pz reduced 1-hour myocardial ischemia reperfusion injury significantly.
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY.
B A
BA
Zikria
C
C
Subbarao
M C
MC
Oz
S J
SJ
Popilkis
R
R
Sachdev
P
P
Chauhan
H P
HP
Freeman
T C
TC
King
D000818:Animals; D001834:Body Water / Q000032:analysis; D003327:Coronary Disease / Q000188:drug therapy; D004285:Dogs; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D007552:Isotonic Solutions / Q000627:therapeutic use; D008954:Models, Biological; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000032:analysis; D011188:Potassium / Q000032:analysis; D000077325:Ringer's Lactate; D012709:Serum Albumin / Q000627:therapeutic use; D013213:Starch / Q000031:analogs & derivatives*
D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012709:Serum Albumin; D013213:Starch; D011188:Potassium