The influence of a histamine2-receptor antagonist on the healing of an experimentally induced gastric mucosal lesion.
The effect of an H2-receptor antagonist (ranitidine) on the healing of gastric mucosal lesions was studied. Mucosal lesions were induced by a standardized thermo-mechanical technique. The healing process was assessed by macro- and light microscopical examination. It was further evaluated by measurements of the tissue contents of hydroxyproline, a chemical compound reflecting collagen, and of DNA and RNA, reflecting cell frequency and protein synthesis respectively, in the gastric wall from both injured and wound-free areas. The healing process was more rapid in ranitidine-treated animals than in controls. After four weeks, however, the lesion in nine out of ten animals had healed in the ranitidine-treated group and seven of nine rats in the control group. At that time the amounts of hydroxyproline, DNA and RNA did not differ between the two groups. These findings may be taken as an indication that the tissue components of the healed lesions were similar in ranitidine-treated rats and in the saline controls, i.e. the different speeds of the healing process did not seem to influence the components of the scar tissue.
Park
P O
PO
Department of Surgery, University of Lund, Malmö General Hospital, Sweden.
Alumets
J
J
Arvidsson
S
S
Grimelius
L
L
Haglund
U
U
D000818:Animals; D002455:Cell Division; D004247:DNA / Q000032:analysis; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000032:analysis / Q000187:drug effects / Q000473:pathology; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D012313:RNA / Q000032:analysis; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013272:Stomach Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D006635:Histamine H2 Antagonists; D012313:RNA; D011899:Ranitidine; D004247:DNA; D006909:Hydroxyproline