Pharmacological profile of flupirtine, a novel centrally acting, non-opioid analgesic drug.
Flupirtine is a new non-opioid, non-addicting centrally acting analgesic. In animals, antinociceptive activity of flupirtine was attenuated after reserpine pretreatment or in the presence of alpha-adrenergic antagonists suggesting the possible involvement of the noradrenergic system in its analgesic mode of action. Additionally, flupirtine possesses skeletal muscle relaxing activity in rats.
Department of Pharmacology, ASTA Pharma AG, Frankfurt/M., FRG.
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Szelenyi
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Nickel
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000631:Aminopyridines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004146:Dioxanes / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation; D019329:Idazoxan; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D010147:Pain Measurement; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000631:Aminopyridines; D000700:Analgesics; D004146:Dioxanes; D012110:Reserpine; C034161:flupirtine; D011224:Prazosin; D019329:Idazoxan