The effects of lindane poisoning on N-acetyldopamine and N-acetyl 5-hydroxytryptamine concentrations in the brain of Locusta migratoria L.
High-performance liquid chromatography with electrochemical detection was used to measure N-acetyldopamine and N-acetyl 5-hydroxytryptamine in the cerebral ganglia of the African migratory locust, Locusta migratoria (fifth instar) exposed to lindane, a chlorinated insecticide. Locusts were poisoned by this insecticide in order to assess the effects of this neuroactive compound on these acetylated metabolites levels. Relatively low concentrations of N-acetyldopamine were observed in the cerebral ganglia. Incubation of ganglia resulted in increased concentrations of N-acetyldopamine and N-acetyl 5-hydroxytryptamine. Lindane significantly reduces N-acetyldopamine and N-acetyl 5-hydroxytryptamine levels in the cerebral ganglia. These results can be correlated with a decrease in N-acetyltransferase activity.
Laboratoire de Zoologie et d'Ecologie, Unité de Recherche Associée au CNRS, Université Paris Sud, Orsay, France.
B
B
Moreteau
N
N
Chaminade
D000287:Administration, Topical; D000588:Amines / Q000378:metabolism; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000037:antagonists & inhibitors; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004298:Dopamine / Q000031:analogs & derivatives* / Q000378:metabolism; D006110:Grasshoppers / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000506:poisoning*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000378:metabolism
D000588:Amines; C006374:N-acetyldopamine; D012701:Serotonin; D001556:Hexachlorocyclohexane; D001191:Arylamine N-Acetyltransferase; C006389:N-acetylserotonin; D004298:Dopamine