Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents.
Comparative effects of CV-6209, a potent and specific platelet activating factor (PAF) antagonist, on PAF-acether-, carrageenin-, histamine-, serotonin-, compound 48/80-, dextran-, zymosan A- and arachidonic acid-induced rat paw edema were investigated. CV-6209 has proven to be effective in PAF-induced edema, but it also showed a significant activity in other models of paw edema, except those induced by zymosan A and arachidonic acid. Other drugs tested, namely indometacin, mepyramine, methysergide and nordihydroguaiaretic acid showed a more selective inhibitory profile. These results suggest an important role of PAF in the inflammatory process caused by intraplantar injection of different phlogogenes in the rat paw.
Research Center, J. Uriach & Cía, S.A., Barcelona, Spain.
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M
Merlos
L A
LA
Gómez
L
L
Vericat
J
J
García-Rafanell
J
J
Forn
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D002351:Carrageenan; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000175:diagnosis*; D006633:Histamine Antagonists; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists; D015054:Zymosan; D003189:p-Methoxy-N-methylphenethylamine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D003911:Dextrans; D006633:Histamine Antagonists; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; D012702:Serotonin Antagonists; C053321:CV 6209; D016718:Arachidonic Acid; D003189:p-Methoxy-N-methylphenethylamine; D002351:Carrageenan; D015054:Zymosan