Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones.
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.
Howard Hughes Medical Institute, Albert Einstein College of Medicine, New York, NY 10461.
P
P
Salgame
J S
JS
Abrams
C
C
Clayberger
H
H
Goldstein
J
J
Convit
R L
RL
Modlin
B R
BR
Bloom
D000917:Antibody Formation; D015704:CD4 Antigens; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D016827:CD8 Antigens; D002999:Clone Cells; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D007918:Leprosy / Q000276:immunology; D008222:Lymphokines / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism
D015704:CD4 Antigens; D016827:CD8 Antigens; D007378:Interleukins; D008222:Lymphokines; D015847:Interleukin-4; D007371:Interferon-gamma