Pharmacological modulation by cetirizine and ebastine of the cutaneous reactivity to histamine.
The peripheral H1-inhibiting effects of cetirizine 10 mg and ebastine 10 mg were compared at the skin level after single oral administration. The study was performed in 9 healthy subjects under double-blind randomized crossover conditions. Both drugs were significantly effective up to 24 h. The suppressive effect of cetirizine was significantly more rapid and more marked.
Unité de Dermatologie professionnelle et de l'Environnement, UCL 3033, Bruxelles, Belgique.
J
J
Rivest
K
K
Despontin
L
L
Ghys
J P
JP
Rihoux
J M
JM
Lachapelle
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000328:Adult; D002090:Butyrophenones / Q000008:administration & dosage / Q000494:pharmacology*; D002214:Capsules; D017332:Cetirizine; D004311:Double-Blind Method; D005260:Female; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006967:Hypersensitivity / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D015999:Multivariate Analysis; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D010919:Placebos; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D013997:Time Factors
D002090:Butyrophenones; D002214:Capsules; D006634:Histamine H1 Antagonists; D010880:Piperidines; D010919:Placebos; D006919:Hydroxyzine; D006632:Histamine; C058249:ebastine; D017332:Cetirizine