[A comparative assessment of heterogeneity of CD4 and CD8 lymphocyte subpopulations in newborns and adults by two-color flow cytometry].
Majority of human newborn CD4+ lymphocytes were suppressor-inducer and had a CD45RA marker, the levels of CD4+Leu8- lymphocytes with helper function were markedly reduced in neonatal blood compared with that of normal adults. Decreased levels of CD8+ lymphocytes in neonate associated with low level of precursors and effectors of allocytotoxic T cells (CD8+CD11b-) and suppressor lymphocytes (CD8+CD11b+).
V P
VP
Chernyshov
I I
II
Slukvin
D000328:Adult; D000375:Aging / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D016176:T-Lymphocyte Subsets; D050378:T-Lymphocytes, Regulatory
Sravnitel'naia otsenka geteroogennosti CD4 i CD8 subpopuliatsiĭ limfotsitov novorozhdennykh i vzroslykh metodom dvukhtsvetnoĭ protochnoĭ tsitofluorimetrii.