[Acute phase proteins and immunoglobulin G in the blood serum and brain tissue in ischemic stroke].
The dynamics of acute phase proteins (fibrinogen, alpha 1-antitrypsin, alpha 2-macroglobulin) and immunoglobulin G in the blood serum was studied and compared in 40 patients with ischemic brain stroke to the localization and distribution of those proteins in the cerebral tissue (4 sectional cases). To measure proteins in the blood and cerebral tissue, use was made of laser nephelometry, radial immunodiffusion and chemical methods with the employment of monoclonal antibodies to the proteins under study. It has been demonstrated that acute phase proteins detected in the blood in the acute period penetrate into the brain, being demonstrable there for a longer time than in the blood, thus attesting to the increased permeability of the blood-brain barrier and low intensity of their tissue metabolism in the area of foci of vascular brain impairment.
Gannushkina
I V
IV
Komel'kova
L V
LV
Mossakovski
M
M
Rafalovska
Ia
Ia
Kraevskiĭ
S Ia
SIa
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000328:Adult; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002545:Brain Ischemia / Q000150:complications*; D002544:Cerebral Infarction / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D005340:Fibrinogen / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000032:analysis / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000032:analysis / Q000378:metabolism
D000209:Acute-Phase Proteins; D007074:Immunoglobulin G; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D005340:Fibrinogen
Belki ostroĭ fazy i immunoglobulin G v syvorotke krovi i tkani mozga pri ishemicheskom insul'te.