High-density molecular map of the central span of the mouse X chromosome.
A total of 17 linking clones previously sublocalized to the central span of the mouse X chromosome have been ordered by detailed analysis through interspecific Mus spretus/Mus musculus domesticus backcross progeny. These probes have been positioned with respect to existing DNA markers utilizing a new interspecific backcross segregating for the Tabby (Ta) locus. The density of clones within this 11.5-cM interval is now, on average, one clone every 1000 kb. This high-density map provides probes in the vicinity of a number of important genetic loci in this region which include the X-inactivation center, the Ta locus, and the mottled (Mo) locus, and therefore provides a molecular framework for identification of the genes encoded at these loci.
Section of Comparative Biology, MRC Clinical Research Centre, Harrow Middlesex, United Kingdom.
N
N
Brockdorff
G
G
Kay
S
S
Smith
J T
JT
Keer
R M
RM
Hamvas
S D
SD
Brown
S
S
Rastan
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D015342:DNA Probes / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D051379:Mice; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D015342:DNA Probes; D005819:Genetic Markers