Effects of tableting pressure on hydration kinetics of theophylline anhydrate tablets.
The effects of tableting pressure on hydration kinetics of types I and II theophylline anhydrate tablets at 95% relative humidity, 35 degrees C, have been studied by using various kinetic equations. Relations between tablet expansion and hydration were studied. Samples of 2 cm diameter tablets (1 g) were compressed at 5, 10 and 20 MPa. The hydration of types I and II tablets decreased with increased tableting pressure. The time required for 50% hydration of 2 cm diameter tablets, compressed at various pressures suggests that the tablet hydration rate was affected by the tableting pressure. Types I and II tablets expanded 11.37-16.75% in volume during hydration to the monohydrate. The thickness expansion of the tablets exceeded the diameter expansion as the tablet structure was not uniform owing to the orientation of particles during the compression. The final expansion ratio of the tablets increased with increased tableting compression pressure. The Hancock Sharp constant (m) and fitting of the kinetic data to a suitable model suggested that the hydration of theophylline anhydrate tablets followed the two-dimensional phase boundary equation (type I tablets) or the three-dimensional phase boundary equation (type II tablets).
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
M
M
Otsuka
N
N
Kaneniwa
K
K
Kawakami
O
O
Umezawa
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004339:Drug Compounding; D004355:Drug Stability; D006813:Humidity; D007700:Kinetics; D011312:Pressure; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage* / Q000737:chemistry; D014867:Water; D014961:X-Ray Diffraction
D013607:Tablets; D014867:Water; D013806:Theophylline