[The action of Sequostat in comparison to Sequence Ovosiston on selected metabolic parameters].
The effects of two sequential oral contraceptive preparations, Sequostat (6 days ethinylestradiol 0.05 mg, 15 days ethinylestradiol 0.05 mg + norethisterone acetate 1.0 mg) and Sequence-Ovosiston (9 days mestranol 0.1 mg, 12 days mestranol 0.08 mg + chlormadinone acetate 2.0 mg) on triglycerides, total cholesterol, HDL- and LDL-Cholesterol, glucose tolerance, total plasma proteins, plasma protein fractions, plasma transaminases, gamma-glutamyl-transferase, alkaline phosphatase and antithrombin III were studied in two groups of 46 and 29 young women respectively. Investigations were performed prior to the hormonal intake and after treatment for 3, 6 and 12 months. In nearly all parameters studied significant but minimal changes could be demonstrated which in most cases showed a minor degree in the Sequostat-group, while Sequence-Ovosiston exerted a less effect on glucose tolerance. A significant increase of HDL-cholesterol and a reduction of LDL/HDL-cholesterol relation could be demonstrated at least in the first six months, resulting from the estrogen dominance of the contraceptives.
Frauenklinik, Bezirkskrankenhauses Gera, DDR.
R
R
Etzrodt
G
G
Klinger
W
W
Carol
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002715:Chlormadinone Acetate / Q000494:pharmacology*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003279:Contraceptives, Oral, Sequential / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008656:Mestranol / Q000494:pharmacology*; D008660:Metabolism / Q000187:drug effects*; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077563:Norethindrone Acetate; D009644:Norgestrel
D001786:Blood Glucose; D001798:Blood Proteins; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D003279:Contraceptives, Oral, Sequential; D008055:Lipids; D002715:Chlormadinone Acetate; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; C002785:Ovosiston; D000077563:Norethindrone Acetate; D008656:Mestranol; D009640:Norethindrone
Wirkung von Sequostat im Vergleich zu Sequenz-Ovosiston auf ausgewählte Parameter des Stoffwechsels.