Stress-induced dependence on endogenous opioid peptides--a fundamental process in the pathophysiology of a disturbed adaptation--its influence by substance P.
Using previous findings of stress-induced disturbances in regulation of peripheral and central function within the general adaptation process and hints from the literature to a multiple participation of opioid peptides in adaptive processes, this paper represents experimental data which gives hints to a functional relation in the etiopathophysiology between the development of stress-induced dependence on endogenous opioid peptides and stress-induced disturbances in blood pressure regulation and to the adaptive effect of substance P within the peptidergic interaction with endogenous opioid peptides and its importance for the physiology or pathophysiology of adaptive processes.
Institute of Drug Research, Academy of Sciences of the GDR.
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I
Roske
K
K
Nieber
P
P
Oehme
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004723:Endorphins / Q000494:pharmacology*; D007103:Immobilization; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D013315:Stress, Psychological / Q000503:physiopathology*; D013373:Substance P / Q000494:pharmacology*; D019966:Substance-Related Disorders / Q000503:physiopathology
D004723:Endorphins; D013373:Substance P; D009270:Naloxone