[The role of prostaglandins in the effect of beta-blockers on stimulated blood platelets].
Atenolol, a selective beta-blocker, slightly potentiates the stimulated aggregation of platelets against dose-dependence. The drug potentiates similarly stimulated release of arachidonic acid, it does not influence the formation of malondialdehyde and the thromboxane B2 production in stimulated platelets. The non-selective beta-blocker propranolol inhibits in a dose-dependent way stimulated aggregation, the release of arachidonic acid, it reduces thromboxane B2 production in stimulated platelets. The authors revealed that the anti-aggregating action of beta-blockers is closely related to their ability to influence prostaglandin synthesis in stimulated platelets.
Ustav experimentálnej farmakológie SAV Bratislava.
R
R
Nosál'
V
V
Jancinová
M
M
Petríková
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001262:Atenolol / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism*; D004357:Drug Synergism; D008315:Malondialdehyde / Q000378:metabolism; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000096:biosynthesis*
D000319:Adrenergic beta-Antagonists; D001095:Arachidonic Acids; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D008315:Malondialdehyde; D001262:Atenolol; D013929:Thromboxane B2; D011433:Propranolol
Uloha prostaglandínov pri pôsobení beta-blokátorov na stimulované krvné dosticky.