Autoantibodies against the multicatalytic proteinase in patients with systemic lupus erythematosus.
Sera from patients with systemic lupus erythematosus contain specific autoantibodies directed against different polypeptide components of the multicatalytic proteinase (also known as proteasome or prosome). These human autoantibodies, in contrast to polyclonal antibodies obtained in rabbits against the purified enzyme, recognize highly conserved epitopes of the multicatalytic proteinase polypeptides from yeast to human.
Departamento de Bioquímica, Facultad de Medicina de la UAM, Spain.
J
J
Arribas
M
M
Luz Rodríguez
R
R
Alvarez-Do Forno
J G
JG
Castaño
D000818:Animals; D001323:Autoantibodies / Q000276:immunology* / Q000302:isolation & purification; D002846:Chromatography, Affinity; D003546:Cysteine Endopeptidases / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D009097:Multienzyme Complexes / Q000276:immunology*; D010053:Ovary / Q000201:enzymology; D010455:Peptides / Q000276:immunology; D046988:Proteasome Endopeptidase Complex; D011817:Rabbits; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D014982:Xenopus laevis
D001323:Autoantibodies; D000939:Epitopes; D009097:Multienzyme Complexes; D010455:Peptides; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex