[The use of the electrophoresis of water-insoluble preparations of fencarol and parmidine from dimexide solutions].
Hepatic mitochondrial respiration was recorded by polarography in various metabolic states using relevant substrates and inhibitors in rat male experiments in vivo and in vitro. The above measurements were made following electrophoresis of parmidine and phencarol in 50% dimexide solution. Parmidine from dimexide solution proved indifferent to mitochondrial energy apparatus, while phencarol could inhibit NADH-dehydrogenase link of the respiratory chain and arrest dimexide inhibition of succinate oxidase system. The findings provided a basis for therapeutic procedures which were tested in 105 patients. The immediate response of coronary and neurodermatitis patients appeared satisfactory.
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Ioshchenko
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Shchekoldin
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Voĭtenok
D000293:Adolescent; D000328:Adult; D000818:Animals; D001559:Benzhydryl Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D002648:Child; D003327:Coronary Disease / Q000188:drug therapy; D004121:Dimethyl Sulfoxide; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007478:Iontophoresis; D008297:Male; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000187:drug effects; D009450:Neurodermatitis / Q000188:drug therapy; D011727:Pyridinolcarbamate / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D012996:Solutions
D001559:Benzhydryl Compounds; D012996:Solutions; D011727:Pyridinolcarbamate; C014742:quifenadine; D004121:Dimethyl Sulfoxide
Primenenie élektroforeza vodonerastvorimykh preparatov fenkarola i parmidina iz rastvorov dimeksida.