Facilitation of the induction of long-term potentiation by GABAB receptors.
Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABAA) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABAB receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABAB receptors is required for induction of LTP by 5-hertz stimulation. GABAB receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.
Mott
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DD
Department of Pharmacology, Duke University Medical Center, Durham, NC 27710.
Lewis
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DV
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D001418:Baclofen / Q000031:analogs & derivatives / Q000494:pharmacology; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D007858:Learning / Q000502:physiology*; D008564:Membrane Potentials; D009433:Neural Inhibition; D009473:Neuronal Plasticity; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D011963:Receptors, GABA-A; D015763:2-Amino-5-phosphonovalerate; D001418:Baclofen; C057491:2-hydroxysaclofen