Importance of histamine for seizure susceptibility.
The influence of drugs affecting the turnover of histamine in brain and histamine antagonists on pentetrazole seizure threshold in mice was studied. A rise in histamine brain concentration as well as treatment with central acting H1-, but not H2- and H3-antagonists led to an increase of the convulsive threshold. It is therefore concluded that histamine has a certain anticonvulsant effect which is mediated through H1-receptors.
Department of Pharmacology and Toxicology, School of Veterinary Medicine, Free University of Berlin.
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Scherkl
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Hashem
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Frey
D000818:Animals; D001921:Brain / Q000378:metabolism; D001958:Brocresine / Q000494:pharmacology; D004115:Dimethindene / Q000494:pharmacology; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D011398:Promethazine / Q000494:pharmacology; D011739:Pyrimethamine / Q000031:analogs & derivatives / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced*
D006633:Histamine Antagonists; D006634:Histamine H1 Antagonists; D001958:Brocresine; C006308:metoprine; D004115:Dimethindene; D006632:Histamine; D006640:Histidine Decarboxylase; D011398:Promethazine; D010433:Pentylenetetrazole; D011739:Pyrimethamine