Myopathy with thick filament (myosin) loss following prolonged paralysis with vecuronium during steroid treatment.
A 20-year-old female hospitalized with status asthmaticus was treated with bronchodilators, antibiotics, and high-dose corticosteroids, and was paralyzed with vecuronium for 10 days to facilitate mechanical ventilation. When this was discontinued, she was found to have a flaccid quadriplegia with areflexia and 4-fold elevation in serum creatine kinase. A muscle biopsy showed extensive loss of thick (myosin) myofilaments, sometimes in core-like distribution, with relative preservation of thin (actin) filaments and Z-discs. Muscle strength returned to normal after 2 months. The pathological lesion in this patient's muscle fibers resemble those in rats treated with high doses of corticosteroids following denervation.
Department of Neurology, University of Illinois, College of Medicine, Chicago 60612.
M J
MJ
Danon
S
S
Carpenter
D000328:Adult; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008775:Methylprednisolone / Q000009:adverse effects*; D009132:Muscles / Q000737:chemistry / Q000648:ultrastructure; D009135:Muscular Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D009218:Myosins / Q000648:ultrastructure*; D010243:Paralysis / Q000139:chemically induced; D012121:Respiration, Artificial; D013224:Status Asthmaticus / Q000188:drug therapy / Q000628:therapy; D014673:Vecuronium Bromide / Q000009:adverse effects*
D014673:Vecuronium Bromide; D009218:Myosins; D008775:Methylprednisolone