Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system.
Intercorrelations among homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-hydroxy-phenylglycol (MHPG) concentrations in lumbar cerebrospinal fluid (CSF) were examined before and after blockade of the acid transport system by probenecid in 59 psychiatric inpatients. The three compounds remained intercorrelated despite acid transport blockade, suggesting that the common transport system does not account for their covariance. Other possibilities to explain the interrelationship among these compounds are discussed.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA.
M
M
Jibson
K F
KF
Faull
J G
JG
Csernansky
D000136:Acid-Base Equilibrium / Q000502:physiology*; D000284:Administration, Oral; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D003866:Depressive Disorder / Q000134:cerebrospinal fluid*; D004305:Dose-Response Relationship, Drug; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D011339:Probenecid / Q000008:administration & dosage / Q000493:pharmacokinetics; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid*; D012559:Schizophrenia / Q000134:cerebrospinal fluid*
D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D011339:Probenecid; D006719:Homovanillic Acid