Abnormal beta and gamma sialoglycoprotein associated with the low-frequency antigen Lsa.
This paper describes the association of the low-frequency antigen Lsa with high-molecular-weight variants of beta- and gamma-sialoglycoproteins (beta-SGP, gamma-SGP). The variant beta-SGP, designated beta Lsa, carries the Ge3 epitope and the epitopes recognised by 3 murine monoclonal anti-beta-SGP antibodies. The variant gamma-SGP, designated gamma Lsa, carries the Ge2 and Ge3 epitopes. Both beta Lsa and gamma Lsa showed enhanced reactions in immunoblotting with anti-Ge3 sera--which may indicate the presence of 2 Ge3 epitopes on beta Lsa and gamma Lsa. These findings would be consistent with the proposed structure of the Lsa glycophorin C gene.
Red Cross Blood Transfusion Service, Brisbane, Queensland.
E B
EB
Macdonald
J
J
Condon
D
D
Ford
B
B
Fisher
L M
LM
Gerns
D000939:Epitopes / Q000032:analysis*; D005260:Female; D006801:Humans; D007519:Isoantigens / Q000032:analysis* / Q000235:genetics; D007983:Lewis Blood Group Antigens / Q000235:genetics / Q000276:immunology*; D008297:Male; D008970:Molecular Weight; D010375:Pedigree; D012795:Sialoglycoproteins / Q000032:analysis*
D000939:Epitopes; D007519:Isoantigens; D007983:Lewis Blood Group Antigens; D012795:Sialoglycoproteins