Pancreatic dose dependent effect of intraduodenal HCl in the anesthetized rabbit.
1. A dose-response relationship between intraduodenal perfusion of different HCl loads (1.8, 4.5, 9, 18 and 45 mmol/hr) and volume, bicarbonate and protein outputs, from the exocrine pancreas of anaesthetized rabbits was observed. 2. This study also shows a dose-response relationship between the different HCl loads and the porta levels of secretin and VIP. 3. The secretin response showed a marked decrease during the stimulation period and this may suggest the involvement of a neural mechanism. 4. The plasma VIP responses were of a magnitude that might suggest a hormone role for VIP in this effect.
Departamento de Fisiologia y Farmacología, Universidad de Salamanca, Spain.
L J
LJ
García
J J
JJ
Calvo
M A
MA
López
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000502:physiology*; D006851:Hydrochloric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007260:Infusion Pumps; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011817:Rabbits; D012633:Secretin / Q000097:blood; D014660:Vasoactive Intestinal Peptide / Q000097:blood
D012633:Secretin; D014660:Vasoactive Intestinal Peptide; D006851:Hydrochloric Acid