Ectopic pregnancy after luteal phase initiation of gonadotropin-releasing hormone analog before in vitro fertilization.
Three patients had an undetected pregnancy when they commenced a GnRH-a on the 21st day of their cycle before ovulation stimulation for IVF. Two of the three pregnancies were later diagnosed as ectopic gestations. Based on this and previous case reports in the literature, it is suggested that luteal phase administration of GnRH-a may predispose to EPs, particularly in patients with damaged tubes, by reducing tubal motility secondary to a transient increase in circulating P concentrations.
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
R
R
Forman
J
J
Robinson
D
D
Egan
C
C
Ross
B
B
Gosden
D
D
Barlow
D000328:Adult; D002064:Buserelin / Q000009:adverse effects* / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000652:urine; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004958:Estradiol / Q000097:blood; D005184:Fallopian Tube Diseases / Q000150:complications*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D010446:Peptide Fragments / Q000652:urine; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000139:chemically induced* / Q000378:metabolism; D011374:Progesterone / Q000097:blood
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D011374:Progesterone; D004958:Estradiol; D002064:Buserelin