Intraocular dapiprazole for the reversal of mydriasis after extracapsular cataract extraction with intraocular lens implantation. Part II: Comparison with acetylcholine.
Intraocular dapiprazole for reversing mydriasis during extracapsular cataract extraction with intraocular lens (IOL) implantation has been compared to intraocular acetylcholine. Ninety patients were enrolled in a double-blind study and divided into three groups of 30 eyes; each group received balanced salt solution (control), 0.25% dapiprazole, or 1% acetylcholine. Pupillary diameter recordings were performed immediately before and a few minutes after drug injection, and two, four and eight hours after surgery. Goldmann tonometry was performed the day before and 6 and 24 hours after surgery. Contact endothelial cell count was performed before and one and four months after surgery. The results indicated a slower starting but longer lasting effect with dapiprazole than with acetylcholine and a significant reduction of the postoperative intraoperative pressure rise with both drugs. No significant difference in reduction in the endothelial cell count was seen between dapiprazole and acetylcholine groups and the control group.
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Clinica Oculistica, Policlinico, Palermo, Italy.
Cillino
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Faranda
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Casanova
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Cucco
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D000109:Acetylcholine / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000368:Aged; D002387:Cataract Extraction; D002452:Cell Count; D004311:Double-Blind Method; D004728:Endothelium, Corneal / Q000166:cytology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D010879:Piperazines; D011680:Pupil / Q000187:drug effects*; D014065:Tonometry, Ocular; D014230:Triazoles / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D010879:Piperazines; D014230:Triazoles; C035289:dapiprazole; D000109:Acetylcholine