[Severe immunoallergic hemolytic anemia caused by a glafenine metabolite].
Three weeks after a surgical operation, a 74-year old woman was admitted to hospital for severe haemolytic anaemia. A strongly positive IgG type direct Coombs test pointed to a iatrogenic origin, but a search for anti-molecule antibodies directed against all medicines taken by the patient after surgery was negative. We extended our immunological investigations and were able to demonstrate the presence of IgG type antibodies directed against an ex vivo metabolite of glafenine.
Vassal
T
T
Service de Réanimation polyvalente, Hôpital Saint-Antoine, Paris.
Lentzy
M
M
Maury
E
E
Guidet
B
B
Offenstadt
G
G
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D005260:Female; D005897:Glafenine / Q000009:adverse effects* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis
D007074:Immunoglobulin G; D005897:Glafenine
Anémie hémolytique immuno-allergique grave provoquée par un métabolite de la glafénine.