Insulin-like growth factor binding proteins (BP) from human placenta are immunologically related to the growth hormone dependent binding protein in adult human serum (BP-53).
Preterm human placentae produce IGF-specific binding proteins. Placental binding proteins are immunologically similar to the growth hormone dependent binding protein in human serum (BP-53) and not the growth hormone independent binding protein (BP-28) in human serum and amniotic fluid. Placental production occurs in mesenchymal cells located in the villous core.
Department of Paediatrics, University of Texas, Southwestern Medical School, Dallas 75235.
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D002352:Carrier Proteins / Q000276:immunology*; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D018969:Insulin-Like Growth Factor Binding Proteins; D010920:Placenta / Q000378:metabolism*; D011233:Precipitin Tests; D011247:Pregnancy
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; C051815:somatotropin-binding protein