Modification of atrioventricular conduction by selective AV nodal artery catheterization.
The effects of selective AV nodal artery embolization on AV nodal function was investigated in six closed-chest adult dogs. Programmed atrial stimulation was performed to determine control values for AV nodal effective refractory period (AVN-ERP) and the paced cycle length at which AV nodal Wenckebach conduction occurred (WCL). Using standard percutaneous femoral techniques of coronary artery catheterization, a flexible infusion catheter was positioned selectively in the AV nodal artery. Proper positioning of the catheter was confirmed angiographically and by selective acetylcholine (ACH) infusion into the AV nodal artery, which caused transient complete AV nodal block in three dogs, and for the group, caused lengthening of both AVN-ERP and WCL. Following cessation of ACH infusion and autonomic blockade with atropine 0.04 mg/kg and propranolol 0.2 mg/kg, denervated recontrol values for AVN-ERP and WCL were 192 msec and 243 msec, respectively. The AV nodal artery was then embolized with a suspension of cross-linked collagen fibrils in either normal saline or absolute ethanol. Successful embolization of the AV nodal artery, confirmed angiographically, caused an acute increase in AVN-ERP (243 msec, P less than 0.05 compared to denervated control) and WCL (287 msec, P = 0.058 compared to denervated control). However, at a mean follow-up of 37 days, only one animal exhibited a chronic increase in AVN-ERP and WCL. Selective AV nodal artery catheterization can be performed using standard percutaneous catheterization techniques. Selective administration of agents with direct cidal effects on the AV node using this technique may provide an alternative to conventional methods of catheter ablation of AV conduction in patients with drug-resistant supraventricular arrhythmias.
Clinical Electrophysiology Laboratory, Brigham and Women's Hospital, Boston, Massachusetts 02115.
P J
PJ
Wang
F J
FJ
Schoen
K
K
Reagan
H H
HH
Hasan
H S
HS
Guo
P L
PL
Friedman
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001283:Atrioventricular Node / Q000187:drug effects / Q000502:physiology*; D006328:Cardiac Catheterization / Q000379:methods*; D002304:Cardiac Pacing, Artificial; D003331:Coronary Vessels / Q000503:physiopathology; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D004621:Embolization, Therapeutic; D005260:Female; D006327:Heart Block / Q000503:physiopathology; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D012032:Refractory Period, Electrophysiological / Q000187:drug effects / Q000502:physiology
D000109:Acetylcholine