Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine.
2 patients had neurological symptoms and signs, with evidence of central-nervous-system demyelination, 6 weeks after administration of recombinant hepatitis B vaccine. 1 had known multiple sclerosis but the other had no history of neurological disease; both had HLA haplotypes DR2 and B7, which are associated with multiple sclerosis. A causal link between vaccination and demyelination cannot be established from these 2 case-reports, but the time interval would fit a proposed immunological mechanism.
Department of Neurology, University Hospital, Free University of Brussels, Belgium.
L
L
Herroelen
J
J
de Keyser
G
G
Ebinger
D000328:Adult; D003711:Demyelinating Diseases / Q000209:etiology*; D005260:Female; D006429:Hemiplegia / Q000209:etiology*; D017325:Hepatitis B Vaccines; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications; D014614:Vaccines, Synthetic / Q000009:adverse effects*; D014761:Viral Hepatitis Vaccines / Q000009:adverse effects*
D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines