Cerebrospinal fluid beta-2-microglobulin in HIV-1 infection, as a marker of neurological involvement.
Cerebrospinal fluid (CSF) and serum concentration of beta-2-microglobulin (beta-2-m) were evaluated in 30 patients in various stages of HIV-1 infection. CSF beta-2-m and CSF/serum ratio were significantly higher in patients with neurological complications respect to asymptomatic subjects. These findings indicate that CSF beta-2-m and CSF/serum ratio may be a useful marker of neurological involvement in HIV-1 infection.
D. Cotugno Hospital for Infectious Diseases, Naples, Italy.
O
O
Perrella
P B
PB
Carrieri
E
E
Izzo
A
A
Marotta
A
A
Liberti
M
M
Soscia
G A
GA
Buscaino
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications; D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000150:complications; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid* / Q000378:metabolism
D015415:Biomarkers; D001613:beta 2-Microglobulin