[The immunotropic properties of fenazepam].
The effect of phenazepam (0.25-10.0 mg/kg) on the humoral immune response, antibody-dependent cellular cytotoxicity (ADCC), the ability of macrophages to induce the humoral immune response at a single administration to Wistar rats and CBA mice was studied. It was found that when administered in doses of 1.0-5.0 mg/kg phenazepam exerts the stimulating effect on the formation of antibodies to the thymus-dependent antigen (ram erythrocytes). When administered in a dose of 2.5 mg/kg the drug increases the titer of antibodies to Vi antigen, ADCC, the ability of macrophages to induce the humoral immune response and also abolishes the studied manifestations of the postintoxication immunodeficiency state caused by anticholinesterase agent.
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Zabrodskiĭ
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology; D007107:Immune System / Q000187:drug effects* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects / Q000276:immunology; D007114:Immunization; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011135:Polysaccharides, Bacterial; D051381:Rats; D011919:Rats, Inbred Strains; D012485:Salmonella typhi / Q000276:immunology; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000942:Antigens, Bacterial; D001570:Benzodiazepinones; D011135:Polysaccharides, Bacterial; D001569:Benzodiazepines; C017928:phenazepam
Immunotropnye svoĭstva fenazepama.