CSF in vivo: effects on hematopoiesis.
A summary of the biological models that Amgen and its collaborators have used to document the biological effects of granulocyte colony-stimulating factor (G-CSF), in particular its profound ability to stimulate granulopoiesis, was presented. Cloned human, bovine and canine G-CSF molecules have been investigated. G-CSF is a highly conservative molecule having 80% homology between human, bovine and canine, and 76% homology with cloned murine G-CSF. Preliminary evidence was advanced on a canine cyclic neutropenic model which affords an excellent opportunity to dissect in vivo homeostasis of neutrophil production. From these studies, it appears that G-CSF is important in the day-to-day maintenance of the neutrophil lineage. The efficacious use of G-CSF was advanced for a variety of non-neutropenic infectious states. These included preclinical burn and pneumonia studies in which animals received G-CSF-supportive treatment.
Souza
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Amgen, Inc., Thousand Oaks, California 91320.
D000818:Animals; D002417:Cattle; D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D004285:Dogs; D016179:Granulocyte Colony-Stimulating Factor; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D051379:Mice
D003115:Colony-Stimulating Factors; D016179:Granulocyte Colony-Stimulating Factor