Effect of 8-methoxypsoralen in the dark on proliferation of stimulated lymphocytes.
The effect of 8-methoxypsoralen (8-MOP) in the dark on proliferation of phytohaemagglutinin-stimulated human lymphocytes has been examined, using total blood leucocytes, the lymphocyte fraction and the T-lymphocyte subpopulation. 8-MOP (1 microgram mL-1) increased [3H]TdR incorporation and caused a rise in the blastic and mitotic index in all experimental cultures. The lymphocyte proliferation in these experiments was effected by a comitogenic effect of 8-MOP on T-lymphocytes.
Department of Medical Genetics, Medical Academy, Lublin, Poland.
G
G
Górski
H
H
Antosz
A
A
Gawron
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003624:Darkness; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008730:Methoxsalen / Q000494:pharmacology*
D008730:Methoxsalen