[Psychomotor and intellectual development in 52 children with congenital hypothyroidism screened at birth. Factors likely to have an effect on prognosis].
Follow-up was obtained for at least 4 years in 52 children (40 F, 12 M) who presented with congenital hypothyroidism, detected by TSH screening at 5 days of age and persisting at the 3th-5th postnatal week. Eight had athyreosis, 33 an ectopic thyroid gland and 11 an anatomically normal thyroid. Treatment began at day 29 +/- 12 (1 SD) with I-T4 solution, 5-7 micrograms/kg/day and was followed in order to obtain immediately T4 and FT4 blood levels in the high normal range, with normal TSH at least from age 6 months. Mental development was evaluated at age 0.5, 1 and 2 years with the Brunet-Lézine scale, and at 4 years with the Termann-Merill test. Thirty of them were reevaluated at age 7 years with the WISC-R test. The results of these tests were all in the normal range, with individual differences, the range being 85 to 145 at 4 years and 95 to 133 at 7 years, not different from those obtained in age-matched controls and in the normal siblings of the patients at 4. The WISC-R test at 7 years did not show differences between verbal and performance levels. Its results were correlated with those of the TM test performed at age 4 years in the same 30 patients: r = 0.75, p less than 0.01. School level at 7 years was normal for age in these 30 hypothyroid children.(ABSTRACT TRUNCATED AT 250 WORDS)
Département de Pédiatrie générale, Endocrinologie et Néonatalogie, Hôpital St-Vincent-de-Paul, Paris.
J E
JE
Toublanc
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S
Rives
A
A
Acosta
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J
Chicaud
D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism; D002658:Developmental Disabilities / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000523:psychology; D007223:Infant; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D011379:Prognosis; D011596:Psychomotor Disorders / Q000209:etiology*; D012959:Socioeconomic Factors; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use
D013974:Thyroxine
Le développement psychomoteur et intellectuel chez 52 enfants atteints d'hypothyroïdie congénitale dépistée à la naissance. Eléments susceptibles d'influer sur le pronostic.