Identification of a T-cell epitope on the circumsporozoite protein of Plasmodium vivax.
A series of overlapping peptides, representing sequences in the vicinity of region II on the Plasmodium vivax circumsporozoite protein, was synthesized. One of the peptides (PV-23), a 20-mer containing the 6 C-terminal amino acids of region II, was found to evoke an in vitro T-cell proliferative response in spleen cells from C3Hf (H-2km2) mice immunized with the peptide. These results demonstrate that PV-23 contains a T-cell epitope. To our knowledge, this is the first report of a T-cell epitope on the circumsporozoite protein of P. vivax.
George
F W
FW
Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033.
Law
J L
JL
Rich
K A
KA
Martin
W J
WJ
D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000032:analysis*; D007114:Immunization; D008213:Lymphocyte Activation; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D010966:Plasmodium vivax / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes