Pharmacological profile of flupirtine, a novel centrally acting, non-opioid analgesic drug.
Flupirtine is a new non-opioid, non-addicting centrally acting analgesic. In animals, antinociceptive activity of flupirtine was attenuated after reserpine pretreatment or in the presence of alpha-adrenergic antagonists suggesting the possible involvement of the noradrenergic system in its analgesic mode of action. Additionally, flupirtine possesses skeletal muscle relaxing activity in rats.
Szelenyi
I
I
Department of Pharmacology, ASTA Pharma AG, Frankfurt/M., FRG.
Nickel
B
B
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000631:Aminopyridines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004146:Dioxanes / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation; D019329:Idazoxan; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D010147:Pain Measurement; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D000631:Aminopyridines; D000700:Analgesics; D004146:Dioxanes; D012110:Reserpine; C034161:flupirtine; D011224:Prazosin; D019329:Idazoxan