[Comparison of salicylazosulfapyridine bioavailability following oral and rectal administration in patients with ulcerative colitis].
Salicylazosulfapyridine--a drug commonly used in the ulcerative colitis--is effective following both oral and rectal administration. Pharmacokinetics of the drug given per rectum (in the form of suppositories) has not been investigated so far. The present study aims at comparing bioavailability of salicylazosulfapyridine following oral and rectal administration to patients with the ulcerative colitis and healthy volunteers. It was found, that following rectal administration the drug is not so readily absorbed as in oral dosage form. No sulfapyridine and 5-aminosalicylic acid have been detected in blood serum, when the drug was given in the form of rectal suppositories. Clinical stage of the disease did not affect absorption of both unchanged drug and its metabolites. Due to the fact, that the drug is active locally, rectal suppositories seem a therapeutical alternative in patients only with lesions localized in the rectum.
Kliniki Gastroenterologii S1, Katowicach.
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Sliwiński
D000284:Administration, Oral; D000285:Administration, Rectal; D000328:Adult; D000368:Aged; D001682:Biological Availability; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012460:Sulfasalazine / Q000008:administration & dosage / Q000493:pharmacokinetics*
D012460:Sulfasalazine
Porównanie biologicznej dostepności salicylazosulfapirydyny po podaniu doustnym i doodbytniczym u chorych na wrzodziejace zapalenie jelita grubego.