Beta-adrenoceptor density of intact mononuclear leukocytes in subgroups of depressive disorders.
Binding parameters of (-)-iodopindolol to beta 2-adrenoceptors were determined on intact mononuclear cells in 41 untreated patients with different DSM-III subtypes of depression. Both maximal beta-receptor density (Bmax) and dissociation constant (Kd) were not significantly different between control and all depressed subjects. However, Bmax was significantly decreased in unipolar patients as compared to controls (p less than 0.001) whereas no significant difference was found in bipolar or dysthymic patients. In unipolar patients, a very strong association was found between Bmax values and the severity of the depression as assessed by the Hamilton Depression Rating Scale score (r = -0.75; p less than 0.005). This correlation was also highly significant in the entire depressed population (r = -0.58; p less than 0.0009). These results suggest that the lower number of beta-adrenoceptors in intact leukocyte cells of depressed patients is related to the depression severity.
Unité de Psychiatrie Biologique, C.N.R.S., Faculté de Médecine, Marseille, France.
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Jeanningros
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Mazzola
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Azorin
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Samuelian-Massa
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Tissot
D000319:Adrenergic beta-Antagonists; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D010869:Pindolol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011569:Psychiatric Status Rating Scales; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D012621:Seasons
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; C029247:3-iodopindolol; D010869:Pindolol