The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5.
We have used a cDNA probe for human complement component 9 (C9), which detects three DNA polymorphisms, to analyse the inheritance of C9 in families informative for C6 protein variants. We found that these genes are closely linked with a lod score of 9.28 at recombination fraction 0.00. There is not indication of allelic association.
Department of Animal Science, Agricultural University, Norway.
S
S
Rogne
O
O
Myklebost
J H
JH
Olving
H T
HT
Kyrkjebø
R
R
Jonassen
B
B
Olaisen
T
T
Gedde-Dahl
D002896:Chromosomes, Human, Pair 6; D003183:Complement C6 / Q000235:genetics*; D003186:Complement C9 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific; D006801:Humans; D008126:Lod Score; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D011995:Recombination, Genetic
D003183:Complement C6; D003186:Complement C9; D015342:DNA Probes; D004247:DNA; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases