Sensitivity of fibroblasts derived from ataxia-telangiectasia patients to calicheamicin gamma 1I.
We report the hypersensitivity of SV40-transformed fibroblasts derived from ataxia telangiectasia (AT) patients to calicheamicin gamma 1I. In common with other free-radical generating agents such as bleomycin and ionizing radiation, treatment with calicheamicin gamma 1I reveals AT derived lines to be 6-fold more sensitive to this drug when compared to controls. Furthermore, in common with ionizing radiation, AT cells did not show dose-dependent inhibition of DNA synthesis after treatment with calicheamicin gamma 1I.
Sullivan
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Imperial Cancer Research Fund, Clare Hall Laboratories, Potters Bar, Herts., Great Britain.
Lyne
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D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D001260:Ataxia Telangiectasia / Q000188:drug therapy*; D001761:Bleomycin / Q000009:adverse effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002472:Cell Transformation, Viral; D004247:DNA / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D053281:Enediynes; D005347:Fibroblasts / Q000187:drug effects*; D008698:Mesylates / Q000009:adverse effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D053281:Enediynes; D008698:Mesylates; C055955:calicheamicin gamma(1)I; D001761:Bleomycin; C066383:ethane methanesulfonate; D004247:DNA