Central nervous system function in systemic lupus erythematosus.
Autoantibodies to three eukaryotic 60S ribosomal phosphoproteins P0, P1 and P2 have been found in the sera of 10-20% of patients with systemic lupus erythematosus (SLE). These antibodies inhibit protein synthesis in vitro and when microinjected into cultured human fibroblasts. The three proteins share a common epitope contained within the carboxyl terminal 22 amino acids of each protein. Because a significant number of SLE patients have central nervous system disturbances with major behavioral disorders, the antiribosomal protein autoantibodies were measured in this subset of SLE individuals to determine whether or not there was an association. These antibodies are present in 90% of SLE patients who were diagnosed as having psychosis, secondary to the disease.
Hospital for Special Surgery, Cornell University Medical College, New York, NY 10021.
K
K
Elkon
H
H
Weissbach
N
N
Brot
D000595:Amino Acid Sequence; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology / Q000494:pharmacology; D000939:Epitopes / Q000276:immunology; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D015151:Immunoblotting; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000276:immunology*; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000276:immunology; D014176:Protein Biosynthesis; D011618:Psychotic Disorders / Q000209:etiology / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology*
D001323:Autoantibodies; D000939:Epitopes; D010750:Phosphoproteins; D012269:Ribosomal Proteins; C031937:phosphoprotein P2, ribosomal; C035690:ribosomal phosphoprotein P1; C054675:ribosomal protein P0