Macrophage-colony stimulating factor (M-CSF) in the cerebrospinal fluid.
In a series of 145 cases with neurological diseases, macrophage-colony stimulating factor (M-CSF) was detected in cerebrospinal fluid of patients with brain tumors, bacterial meningitis, and less frequently, AIDS-dementia complex. Granulocyte-colony stimulating factor (G-CSF) was found only in patients with bacterial meningitis; granulocyte-macrophage (GM)-CSF was never detected. These findings suggest that M-CSF may play an important intrathecal immunoregulatory role in neoplastic and infectious diseases of the central nervous system.
Gallo
P
P
Second Neurologic Clinic, University of Padua, School of Medicine, Italy.
Pagni
S
S
Giometto
B
B
Piccinno
M G
MG
Bozza
F
F
Argentiero
V
V
Tavolato
B
B
D000818:Animals; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000134:cerebrospinal fluid; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000134:cerebrospinal fluid; D015658:HIV Infections / Q000134:cerebrospinal fluid; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000134:cerebrospinal fluid*; D008581:Meningitis / Q000134:cerebrospinal fluid; D051379:Mice; D008807:Mice, Inbred BALB C; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D014409:Tumor Necrosis Factor-alpha; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor