[Analysis of the effectiveness of pilocarpine in the management of xerostomia].
The authors have studied the "sympathetic like" side effect of pilocarpine after single injection (1 mg/100 g b.w., i.p.) of the drug. They developed a system for the continuous automatic recording the amylase activity of the saliva secreted by the parotid glands of rats, "in situ". Pilocarpine stimulus was characterized by a peak in amylase activity--regularly observed in the first 40-60 min--which was additive to the cholinergic amylase secretory response. After this the amylase secretion was continued with lower activity. The role of a beta-adrenergic component in the pilocarpine stimulus appears to be supported by the finding that propranolol (2.5 mg/100 g b.w., i.p.) pretreatment applied 30 min prior to the pilocarpine stimulus prevented the appearance of the characteristic amylase peak. These data support that the beta-adrenergic side effect triggering the periodical synthesis of export proteins during the course of pilocarpine treatment accounts for the selative efficiency of pilocarpine in the therapy of xerostomia.
Zelles
T
T
Semmelweis Orvostudományi Egyetem Orálbiológiai Tanszék, Budapest.
Blazsek
J
J
Kelemen
E
E
D000681:Amylases / Q000378:metabolism; D006801:Humans; D010862:Pilocarpine / Q000494:pharmacology / Q000627:therapeutic use*; D012463:Saliva / Q000201:enzymology / Q000378:metabolism; D014987:Xerostomia / Q000188:drug therapy* / Q000201:enzymology
D010862:Pilocarpine; D000681:Amylases
A pilocarpin hatékonyságágak elemzése a xerostomia kezelésében.