[Conjunctival oxygen partial pressure, hemorheology and circulatory parameters in acute cerebral infarct before and following infusion of 6 percent low molecular hydroxyethyl starch].
A prospective clinical trial was performed on the effects of a three hour infusion of 500 ml 6% low-molecular-weight hydroxyethyl starch in patients with acute ischemic stroke. Hemorheology and conjunctival oxygen tension were found to be disturbed prior to treatment. After the infusion there was a marked improvement of the pertinent parameters, indicative of an increase in cerebral microcirculation and oxygen supply. Even 3 h later persistent significant effects were observed. The infusion was well tolerated. Blood pressure and cardiac index remained unchanged.
I. Medizinische Klinik, Universität Heidelberg.
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Kortsik
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Staedt
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Stein
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Geiger
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Buss
D001809:Blood Viscosity / Q000187:drug effects; D002544:Cerebral Infarction / Q000097:blood / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003228:Conjunctiva / Q000378:metabolism*; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007260:Infusion Pumps; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D013213:Starch / Q000031:analogs & derivatives*
D006895:Hydroxyethyl Starch Derivatives; D013213:Starch; D010100:Oxygen
Konjunktivaler Sauerstoffpartialdruck, Hämorheologie und Kreislaufparameter bei akutem zerebralem Insult vor und nach Infusion von 6prozentiger niedermolekularer Hydroxyäthylstärke.