Effect of short-chain organic acids on macromolecular synthesis in Escherichia coli.
Incubating cultures of Escherichia coli with propionic acid (5 mmol/l) or formic acid (10 mmol/l) at pH 5.0 produced bacteriostasis lasting 30 and 120 min respectively. During this time rates of RNA, DNA, protein, lipid and cell wall synthesis were reduced. Growth resumed after continued incubation in the presence of acid, but cells from acid-treated cultures were larger than controls. DNA synthesis was particularly sensitive to the presence of the propionic or formic acid.
Department of Microbiology, Medical School, University of Bristol, UK.
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Cherrington
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Hinton
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Chopra
D001426:Bacterial Proteins / Q000096:biosynthesis; D002473:Cell Wall / Q000378:metabolism; D004269:DNA, Bacterial / Q000096:biosynthesis; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D005561:Formates / Q000494:pharmacology*; D008055:Lipids / Q000096:biosynthesis; D011422:Propionates / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D005561:Formates; D008055:Lipids; D011422:Propionates; D012329:RNA, Bacterial