Detection of major group rhinoviruses by soluble intercellular adhesion molecule-1 (sICAM-1).
Soluble intercellular adhesion molecule-1 (sICAM-1) was shown to be the receptor for the major subgroup of rhinoviruses. It was demonstrated that this molecule can inhibit the binding and subsequent infection of target cells by rhinoviruses belonging to the major but not the minor subgroup. The data reported now describe an ELISA-based system utilizing biotinylated sICAM-1 as a means of detecting rhinoviruses belonging to the major subgroup.
Department of Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
K
K
Last-Barney
S D
SD
Marlin
E J
EJ
McNally
C
C
Cahill
D
D
Jeanfavre
R B
RB
Faanes
V J
VJ
Merluzzi
D001426:Bacterial Proteins; D001710:Biotin; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003588:Cytopathogenic Effect, Viral; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D011991:Receptors, Virus / Q000378:metabolism*; D012229:Rhinovirus / Q000145:classification / Q000378:metabolism* / Q000472:pathogenicity; D019809:Streptavidin
D001426:Bacterial Proteins; D015815:Cell Adhesion Molecules; D011991:Receptors, Virus; D018799:Intercellular Adhesion Molecule-1; D001710:Biotin; D019809:Streptavidin