Population spike facilitation in the dentate gyrus following glutamate to the lateral supramammillary nucleus.
Glutamate stimulation of the lateral supramammillary nucleus (SUL) in urethane anaesthetized rats produced a substantial increase in the amplitude of the perforant path-evoked population spike in the dentate gyrus, without affecting the population EPSP slope. One third of the spike enhancements lasted longer than 20 min. These data suggest that SUL afferents provide a mechanism for both short- and long-lasting heterosynaptic modulation of hippocampal throughput.
Department of Psychology, Memorial University, St. John's, Newfoundland, Canada.
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D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005971:Glutamates / Q000008:administration & dosage / Q000494:pharmacology*; D018698:Glutamic Acid; D006624:Hippocampus / Q000502:physiology*; D008326:Mammillary Bodies / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D005971:Glutamates; D018698:Glutamic Acid