Resolution of primary murine listeriosis and acquired resistance to lethal secondary infection can be mediated predominantly by Thy-1+ CD4- CD8- cells.
Mice depleted of CD4+, CD8+, Thy-1+ CD4- CD8-, or all three types of cells by appropriate monoclonal antibody treatment were tested for their ability to express resistance against a primary and secondary Listeria monocytogenes infection. It was found that mice depleted of CD8+, CD4+, or both of these subsets of T cells remained capable of controlling and then resolving both a primary infection and a secondary infection lethal for normal animals. In contrast, depleting mice of a population of Thy-1+ CD8- CD4- cells that remain after CD4+ and CD8+ T cells had been removed, rendered them incapable of resolving a sublethal primary infection or of expressing acquired immunity to a lethal secondary infection. The results point to the possibilities that Thy1+ CD4- CD8- alpha beta T cells, Thy1+ CD4- CD8- gamma delta T cells, Thy-1+ NK cells, or all three types of these host cells are involved in anti-L. monocytogenes resistance.
Trudeau Institute, Saranac Lake, New York 12983.
P L
PL
Dunn
R J
RJ
North
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D007111:Immunity, Cellular; D008089:Listeria monocytogenes / Q000276:immunology / Q000302:isolation & purification; D008088:Listeriosis / Q000276:immunology*; D008099:Liver / Q000382:microbiology; D008297:Male; D051379:Mice; D013154:Spleen / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*