Effect of selective decontamination of the digestive tract on respiratory tract infections and mortality in the intensive care unit.
To assess the effect of selective decontamination of the digestive tract on respiratory tract infections and survival of patients treated in an intensive care unit, we carried out a meta-analysis of clinical studies comparing patients treated with selective decontamination with untreated controls. From eleven trials (1489 patients), differences between observed and expected respiratory tract infections and mortality were compared, and odds ratios (ORs) calculated. Analysis was done according to study design. With respect to the risk for respiratory tract infections, the studies with historical controls and the randomised trials showed a protective effect of selective decontamination. Historical control studies yielded an OR of 0.21 (95% confidence limits [CL] 0.15 to 0.29, p less than 0.05) and randomised trials an OR of 0.12 (95% CL 0.08 to 0.19, p less than 0.05). By contrast, the mortality benefit was less clear. Studies with historical controls and randomised trials showed that mortality was not significantly different between treatment and control patients. The evidence from these studies is at best consistent with a very limited effect of selective decontamination of the digestive tract on survival of patients in the intensive care unit, despite a clear preventive effect on the occurrence of respiratory tract infections.
Department of Clinical Microbiology, Utrecht University Hospital, The Netherlands.
C M
CM
Vandenbroucke-Grauls
J P
JP
Vandenbroucke
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004064:Digestive System / Q000187:drug effects* / Q000382:microbiology; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D015201:Meta-Analysis as Topic; D011292:Premedication; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents