Heterogeneity of transplantable melanomas differing in the rate of growth and cellular differentiation in relation to their cell transglutaminase activity.
Transglutaminase activity has been investigated by the fluorescent method in cells of two transplantable melanoma lines of the same origin but differing in rate of growth and the degree of differentiation. Transglutaminase activity within the cells under examination was not the same. In comparison with the original melanotic line, the amelanotic melanoma line, less differentiated and growing faster, was characterized by a greater heterogeneity of cells with regard to transglutaminase activity, and it also displayed greater activity of the enzyme.
Laboratory for Cytophysiology, Department of Histology, Medical Academy, Gdańsk, Poland.
K
K
Kozłowska
M
M
Cichorek
B
B
Zurawska-Czupa
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006224:Cricetinae; D005455:Fluorescent Antibody Technique; D008297:Male; D008544:Melanocytes / Q000201:enzymology; D008545:Melanoma / Q000378:metabolism / Q000473:pathology*; D009368:Neoplasm Transplantation; D011503:Transglutaminases / Q000378:metabolism*
D011503:Transglutaminases