Erythrocyte glutathione metabolism in human chronic fluoride toxicity.
Chronic exposure of humans to toxic levels of fluoride in drinking water resulted in significant increase in blood GSH content with significant increase in the activities of erythrocyte glutathione metabolising enzymes viz., gamma-glutamylcysteine synthetase (E.C. 6.3.2.2), gamma-glutamyltranspeptidase (E.C. 2.3.2.2), GST (E.C. 2.5.1.18), GSH-Px (E.C. 1.11.1.9) and GR (E.C. 1.6.4.2). The data suggested a form of adaptation on the part of the erythrocytes to counteract the oxidative stress in red blood cells of fluorotic patients.
Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, India.
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Saralakumari
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Rao
D000328:Adult; D002908:Chronic Disease; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005458:Fluoride Poisoning / Q000097:blood* / Q000201:enzymology; D005721:Glutamate-Cysteine Ligase / Q000097:blood; D005978:Glutathione / Q000097:blood* / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D005982:Glutathione Transferase / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007194:India; D008297:Male; D010084:Oxidation-Reduction; D005723:gamma-Glutamyltransferase / Q000097:blood
D006454:Hemoglobins; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005721:Glutamate-Cysteine Ligase; D005978:Glutathione