Binding and detoxification of heavy metals in lower vertebrates with reference to metallothionein.
1. The metabolism of Cu, Zn, Cd and Hg in lower vertebrates is described, using fish as a model. 2. The main part of this review deals with metallothionein and the role of this protein for the storage and detoxification of these metals. 3. Factors influencing the bioavailability and probable uptake routes are identified. 4. The distribution of the metals within the organism is outlined. The distribution between tissues is described and the subcellular distribution discussed with reference to metallothionein.
Hogstrand
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Department of Zoophysiology, University of Göteborg, Sweden.
Haux
C
C
D000818:Animals; D005399:Fishes / Q000378:metabolism*; D008658:Inactivation, Metabolic / Q000502:physiology; D008668:Metallothionein / Q000502:physiology*; D008670:Metals / Q000378:metabolism* / Q000493:pharmacokinetics; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution / Q000502:physiology
D008670:Metals; D008668:Metallothionein