[Experimental substantiation of the method of pharmaco-metabolic brain protection against hypoxia in severe craniocerebral injury].
The experiment has shown that a complex of functionally related vitamins including thiamine, lipoate, D-pantothenate, nicotinate and riboflavine in "pyruvate-dehydrogenase" ratios decreases inhibition of the activity of alpha-keto acid dehydrogenases in the brain and liver with thiopental anesthesia, intensifies arrival of [35S]-lipoate to the brain and decreases acute toxicity of sodium thiopental (TnNa). The same complex (where thiamine, pantothenate and riboflavine are substituted by the corresponding coenzyme forms) complemented by the components stimulating the function of GABA-bypath of the brain as administered to rats with serious craniocerebral injury on the background of prolonged anaesthesia effect improves recovery of the brain functions, that is followed by normalization of ketoglutarate-dehydrogenase activity, maintenance of GABA-bypath function and by a decrease of GABA and glutamate content in the brain. The results obtained substantiate the advisability to use vitamin-coenzyme-metabolic complex in the acute period of traumatic brain disease aimed to increase efficiency of the antihypoxic TnNa effect and to correct its undesirable effects.
Rozanov
V A
VA
Tsepkolenko
V A
VA
Levitskiĭ
M V
MV
Galich
I M
IM
Rozanov
A Ia
AIa
Korol'
A P
AP
Nasibullin
B A
BA
D000818:Animals; D001930:Brain Injuries / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D002534:Hypoxia, Brain / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D010088:Oxidoreductases / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013874:Thiopental / Q000037:antagonists & inhibitors; D014815:Vitamins / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D014815:Vitamins; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D010088:Oxidoreductases; D013874:Thiopental
Eksperimental'noe obosnovanie sposoba farmakometabolicheskoĭ zashchity mozga ot gipoksii pri tiazheloĭ cherepno-mozgovoĭ travme.