Associated leukemia and mixed germ cell tumor in a patient with gonadal dysgenesis.
A 16-year-old phenotypic female developed acute myeloblastic leukemia with a fulminant course very shortly after surgery and chemotherapy for a mixed germ cell tumor of the ovary. The karyotype (46, XY, 47, XY + 8) suggested de novo rather than therapy-associated leukemia. The relationship between germ cell tumors and leukemia, their common yolk sac derivation and the role of the Y chromosome are discussed. The idea that XY gonadal dysgenesis may be familial also is discussed.
Department of Pathology, University of Pittsburgh School of Medicine, PA.
S S
SS
Kaplan
S G
SG
Bornstein
W A
WA
Christopherson
U
U
Surti
D000293:Adolescent; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000150:complications* / Q000235:genetics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*