Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).
Part I of this article, which appeared in the previous issue of the Journal, discussed the scope of and scientific basis for special pharmacokinetic studies of anxiolytic and hypnotic drugs in the elderly, and examined the methodology and results of such studies and the prediction of pharmacokinetic changes. In Part II the authors continue their review, focusing on age-related pharmacodynamic changes in the effects of these drugs, the attempts to correlate pharmacokinetic with pharmacodynamic findings, and the clinical applications of these data.
Greenblatt
D J
DJ
Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts.
Harmatz
J S
JS
Shader
R I
RI
D000368:Aged; D000375:Aging / Q000378:metabolism*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001569:Benzodiazepines; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D011963:Receptors, GABA-A / Q000378:metabolism
D014151:Anti-Anxiety Agents; D011963:Receptors, GABA-A; D001569:Benzodiazepines