The use of 16,16-dimethyl-trans-delta 2 prostaglandin E1 methyl ester vaginal suppositories for management of missed abortion and fetal death.
The effect of vaginal administration of a PgE1 analogue to terminate missed abortion and fetal death in utero was evaluated in 62 women with gestation ranging from the 13th to the 37th week. Abortion occurred in 85.4% of women with missed abortion and in 86% of women with fetal death. In both groups, the mean induction time was less than 12 h. The incidence of side effects, primarily gastrointestinal symptoms, was infrequent.
Fruzzetti
F
F
Department of Obstetrics and Gynecology, Pisa University, Italy.
Melis
G B
GB
De Cecco
L
L
Genazzani
A R
AR
Fioretti
P
P
D000030:Abortion, Missed / Q000188:drug therapy*; D000282:Administration, Intravaginal; D005260:Female; D006801:Humans; D010570:Pessaries; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000627:therapeutic use*
D011459:Prostaglandins E, Synthetic; C017244:16,16-dimethylprostaglandin E