High alveolar surface tension increases clearance of technetium 99m diethylenetriamine-pentaacetic acid.
The effect of high alveolar surface tension on alveolar epithelial permeability was studied in anesthetized closed-chest mongrel dogs. Alveolar surface tension was elevated by displacement of pulmonary surfactant from the alveolar hypophase by the aerosolized detergent dioctyl sodium sulfosuccinate (OT). After measurement of baseline hemodynamics, arterial blood gases, and airway pressure, the dogs were separated into groups: Group I inhaled a 1% solution of OT (15 mg/kg) in a vehicle of equal parts saline and ethanol; group II inhaled the same volume of vehicle without OT. The pulmonary clearance of technetium 99m diethylenetriamine-pentaacetic acid (99mTc-DTPA) (half-time in minutes) was studied immediately after aerosol (OT and vehicle) delivery and compared with that of historical control values. No change was seen in arterial blood gases and airway pressure after vehicle inhalation, whereas OT caused a marked fall in arterial oxygen tension and increase in airway pressure. Vehicle inhalation effected only a slight increase in DTPA clearance, whereas OT significantly reduced half-time over control and group II. These data suggest that high alveolar surface tension increases alveolar epithelial permeability.
Nieman
G
G
Department of Surgery, SUNY Health Science Center, Syracuse 13210.
Ritter-Hrncirik
C
C
Grossman
Z
Z
Witanowski
L
L
Clark
W
W
Bredenberg
C
C
D000336:Aerosols; D000818:Animals; D004143:Dioctyl Sulfosuccinic Acid / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D015609:Organotechnetium Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics; D010539:Permeability; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013500:Surface Tension; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000494:pharmacology; D016284:Technetium Tc 99m Pentetate
D000336:Aerosols; D015609:Organotechnetium Compounds; D013501:Surface-Active Agents; D004143:Dioctyl Sulfosuccinic Acid; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate