[Changes in neurotransmitters uptake and their receptors binding after transplanting adrenal medullary tissue into central striatum in rats].
Unilateral nigrostriatal pathway of rats was destroyed by using injection of 6-hydroxydopamine (6-OHDA), presenting the rotative movement model and transplanting isogenous rat adrenal medullary tissues into their lesioned lateral caudate nucleus. After 2 months, the rotative movement almost abolished by 34% out of the total transplanted rats, and it was significantly reduced by 57% of the same rats. Taking the above rats brain synaptosome, we found the lesioned side, the uptake of tyrosine, dopamine and choline increased significantly, nevertheless, in another group which transplanted with adrenal medullary tissue, the uptake of same neurotransmitters recover to the normal level. In addition, we also found that dopamine (DA2) receptor binding increased remarkably but muscarinic and GABAA receptors binding decreased significantly in lesioned side brain synaptic membrane, while the transplanted group didn't shown such changes.
Zuo
P
P
Institute of Basic Medical Sciences, Beijing.
D000313:Adrenal Medulla / Q000637:transplantation*; D000818:Animals; D001921:Brain / Q000601:surgery*; D002794:Choline / Q000378:metabolism; D003342:Corpus Striatum / Q000601:surgery; D004298:Dopamine / Q000378:metabolism; D005260:Female; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism
D018377:Neurotransmitter Agents; D011954:Receptors, Dopamine; D011963:Receptors, GABA-A; D011976:Receptors, Muscarinic; D017981:Receptors, Neurotransmitter; D014443:Tyrosine; D002794:Choline; D004298:Dopamine