North Carolina macular dystrophy: exclusion map using RFLPs and microsatellites.
The autosomal dominant macular dystrophies are a confusing group of poorly understood diseases. Linkage studies will greatly aid our classification of these disorders and hopefully provide insight into central retinal function and dysfunction such as occurs in age-related macular degeneration. North Carolina macular dystrophy is one such disease that has been amenable to linkage analysis because of the large pedigree size. Seventy-six polymorphic markers have been tested for linkage and exclusion data are presented.
Small
K W
KW
Department of Ophthalmology, Medical University of South Carolina, Charleston 29425.
Weber
J L
JL
Hung
W Y
WY
Vance
J
J
Roses
A
A
Pericak-Vance
M
M
D002874:Chromosome Mapping; D004276:DNA, Satellite / Q000235:genetics*; D005799:Genes, Dominant / Q000235:genetics; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D009657:North Carolina; D012150:Polymorphism, Restriction Fragment Length
D004276:DNA, Satellite