Purification of achatin-I from the atria of the African giant snail, Achatina fulica, and its possible function.
Achatin-I previously purified from the ganglia of the African giant snail Achatina fulica was isolated from the atria of this snail. Achatin-I appeared to enhance the cardiac activity in two ways; centrally this peptide increased impulse frequency and produced spike broadening of the identified heart excitatory neuron, PON, and peripherally it enhanced amplitude and frequency of the heart beat. Achatin-I showed excitatory actions not only on the heart but on several other muscles.
Physiological Laboratory, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
K
K
Fujimoto
I
I
Kubota
Y
Y
Yasuda-Kamatani
H
H
Minakata
K
K
Nomoto
M
M
Yoshida
A
A
Harada
Y
Y
Muneoka
M
M
Kobayashi
D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004558:Electric Stimulation; D006325:Heart Atria / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects; D007447:Invertebrate Hormones / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D009479:Neuropeptides / Q000302:isolation & purification* / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000302:isolation & purification* / Q000494:pharmacology; D010413:Penis / Q000187:drug effects; D012908:Snails
D007447:Invertebrate Hormones; D009479:Neuropeptides; D018377:Neurotransmitter Agents; C059927:achatin I