Morphological and quantitative aspects of the development of cytoplasmic granules in concanavalin A-stimulated normal human lymphocytes.
We have studied normal human lymphocytes stimulated by concanavalin A to determine the rate and extent of development of cytoplasmic granules. Morphological studies on stimulated lymphocytes were undertaken at the light and electron microscopic level. The percentage of T lymphocytes bearing different CD antigens (CD3, CD4, and CD8) that also contained cytoplasmic granules was also assessed. Granules were identified in a high percentage of lymphocytes bearing each of the three CD markers studied.
Department of Pathology, University College Dublin, Ireland.
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A
McGirl
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Shea
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Melinn
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McLaughlin
D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D003208:Concanavalin A / Q000494:pharmacology*; D003594:Cytoplasmic Granules / Q000502:physiology / Q000648:ultrastructure*; D006801:Humans; D008213:Lymphocyte Activation / Q000502:physiology*; D008854:Microscopy, Electron / Q000379:methods; D013194:Staining and Labeling; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
D003208:Concanavalin A