Effect of B-HT 920 on cardiotoxic effects of ouabain in guinea pigs.
Effect of B-HT 920, a selective alpha 2 adrenoceptor agonist, was studied on ouabain induced cardiac arrhythmias and cardiac arrest in guinea pigs. Ventricular premature beats, ventricular tachyarrhythmias and cardiac arrest were induced in anaesthetized guinea pigs by slow infusion of ouabain. B-HT 920 accorded significant protection to guinea pigs against ouabain induced arrhythmias. Yohimbine inhibited the antiarrhythmic effect of B-HT 920 significantly. It is concluded that the protective effect of B-HT 920 against ouabain induced cardiac arrhythmias and cardiac arrest is mediated through the stimulation of alpha 2 adrenoceptors.
Department of Pharmacology, IDPL Research Centre, Hyderabad, India.
G P
GP
Thomas
R
R
Kaushal
R M
RM
Tripathi
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D001381:Azepines / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006323:Heart Arrest / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010042:Ouabain / Q000633:toxicity*
D000316:Adrenergic alpha-Agonists; D001381:Azepines; D010042:Ouabain; C024763:talipexole