[Effect of phentolamine in combination with pituitrin on the hepatic and systemic hemodynamics].
This experimental study was aimed at the effect of phentolamine used separately or in combination with pituitrin on hepatic and systemic hemodynamics in cirrhotic portal hypertensive dogs. The results showed that either of these drugs used separately could lead to reduction of portal venous pressure. Each of the drugs could also cause by-effect on systemic hemodynamics, or reduce hepatic blood flow. When phentolamine was used in combination with pituitrin no side effect was found in hepatic and systemic hemodynamics. It was suggested that phentolamine used in combination with pituitrin could efficiently decrease portal hypertension and counteract the side-effects. It would be useful in treatment of bleeding from esophageal variceal rupture in cirrhotic patients with portal hypertension.
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D000818:Animals; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006975:Hypertension, Portal / Q000188:drug therapy / Q000503:physiopathology; D008102:Liver Circulation / Q000187:drug effects*; D008106:Liver Cirrhosis, Experimental / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D010909:Pituitary Hormones, Posterior / Q000008:administration & dosage / Q000494:pharmacology*
D010909:Pituitary Hormones, Posterior; D010646:Phentolamine