Oral pharmacokinetics of fluazifop-butyl in human volunteers.
1. Fluazifop-butyl, the active ingredient of FUSILADE, a selective herbicide, was administered orally to three male volunteers at a dose level of 0.07 mg kg-1 body weight. Over a period of 6 d between 80 and 93% of the dose was excreted in urine as the metabolite fluazifop, the majority within the first 24 h. Peak plasma concentrations of fluazifop occurred 1-2.5 h after administration. 2. The elimination of fluazifop from plasma and urine can be described by a one-compartment pharmacokinetic model and the elimination half-life was estimated from blood and urine data to be within the range 9-37 h. Fluazifop was found to bind to serum proteins. 3. The study indicates that the amount of fluazifop-butyl absorbed in exposed persons can be assessed by measuring fluazifop concentrations in urine.
ICI Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK.
B H
BH
Woollen
T B
TB
Hart
P L
PL
Batten
W J
WJ
Laird
D S
DS
Davies
C T
CT
Dollery
D000284:Administration, Oral; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D004095:Dihydropyridines / Q000097:blood / Q000652:urine; D005243:Feces / Q000737:chemistry; D006540:Herbicides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D011725:Pyridines / Q000008:administration & dosage / Q000493:pharmacokinetics*
D001798:Blood Proteins; D004095:Dihydropyridines; D006540:Herbicides; D011725:Pyridines; C050585:fluazifop-butyl; C050582:fluazifop