The effects of some neuroleptics and d-amphetamine on striatal 2-phenylethylamine in the mouse.
1. Mouse striatal 2-phenylethylamine was not changed at 2 hr following the administration of chlorpromazine, fluphenazine or spiperone. 2. In contrast, when the mice were first given pargyline (2 mg kg-1), treated with chlorpromazine, fluphenazine or spiperone 2 hr later and killed at 4 hr, a significant increase (to 130-170%) in the accumulation of 2-phenylethylamine was observed with respect to the pargyline controls. 3. The effect of chlorpromazine was consistently observed after pretreatment with either deprenyl (2 mg kg -1) or high doses (200 mg kg-1) of pargyline that produced different degrees of MAO inhibition. 4. Following pretreatment with pargyline (2 mg kg-1), d-amphetamine (5 mg kg-1) produced a significant reduction in striatal 2-phenylethylamine concentrations (to 39% of pargyline-treated controls). 5. The findings show that inhibition of dopamine transmission by neuroleptics increases the rate of 2-phenylethylamine accumulation. 6. Conversely, a stimulation of dopamine transmission by d-amphetamine results in a reduction in the rate of accumulation of 2-phenylethylamine and supports the concept of 2-phenylethylamine may be a neuromodulator of dopamine transmission.
Department of Psychiatry, University of Saskatchewan, Saskatoon, Canada.
A V
AV
Juorio
A J
AJ
Greenshaw
M Y
MY
Zhu
I A
IA
Paterson
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002746:Chlorpromazine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology; D005476:Fluphenazine / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D010627:Phenethylamines / Q000378:metabolism*; D012642:Selegiline / Q000494:pharmacology; D013134:Spiperone / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects
D014150:Antipsychotic Agents; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D015102:3,4-Dihydroxyphenylacetic Acid; D012642:Selegiline; C029261:phenethylamine; D013134:Spiperone; D010293:Pargyline; D005476:Fluphenazine; D003913:Dextroamphetamine; D002746:Chlorpromazine; D004298:Dopamine; D006719:Homovanillic Acid