Kinetics of serotonin in platelets in essential hypertension.
In a study of the kinetics of 5-hydroxytryptamine (5-HT) in platelets in 26 hypertensive subjects with a mean systolic and diastolic blood pressure of 153.9 +/- 26.9 and 106.9 +/- 9.1 mm Hg respectively, it has been observed that in hypertensive platelets there was a marked decrease in 5-HT uptake and content, an increase in 5-HT efflux and an accompanying increase in Plasma 5-HT and 5-HIAA levels. Regression analysis of the data indicated a significant correlation between rise in diastolic blood pressure and these changes in 5-HT kinetics.
Department of Medicine, King George's Medical College, Lucknow, India.
S
S
Nityanand
B L
BL
Tekwani
M
M
Chandra
K
K
Shanker
B N
BN
Singh
D001792:Blood Platelets / Q000378:metabolism*; D001794:Blood Pressure; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D006973:Hypertension / Q000097:blood*; D007700:Kinetics; D012044:Regression Analysis; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid