The pharmacology of pramipexole in the spontaneously hypertensive rat.
Pramipexole (SND-919) administration to spontaneously hypertensive rats resulted in a biphasic response with lower doses (1-30 micrograms/kg) causing a hypotensive response and higher doses (100-1000 micrograms/kg) increasing blood pressure. S-Sulpiride (1 mg/kg i.v.) and domperidone (100 micrograms/kg i.v.) but not SCH 23390(1 microgram/kg per min i.a.), prazosin (0.1 mg/kg i.v.) or rauwolscine (1 mg/kg i.v.) blocked the depressor effect, whereas rauwolscine but not S-sulpiride, SCH 23390 or prazosin blocked the pressor effects. The data indicate that pramipexole stimulates presynaptic DA2 receptors at low doses and postsynaptic alpha 2-receptors at high doses.
Brooks
D P
DP
SmithKline Beecham Pharmaceuticals, Department of Pharmacology, King of Prussia, PA 19406-0939.
Weinstock
J
J
D000818:Animals; D052160:Benzothiazoles; D001794:Blood Pressure / Q000187:drug effects; D015259:Dopamine Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D000077487:Pramipexole; D051381:Rats; D011918:Rats, Inbred SHR; D013844:Thiazoles / Q000494:pharmacology*
D052160:Benzothiazoles; D015259:Dopamine Agents; D013844:Thiazoles; D000077487:Pramipexole