Resistance of Escherichia coli to rifampicin and sorangicin A--a comparison.
Sorangicin A, a macrolide polyether antibiotic and the ansamycin antibiotic rifampicin inhibit DNA-dependent RNA polymerase to a similar extent. Resistance to sorangicin A is due to a mutation in the RNA polymerase which renders the enzyme less sensitive. Parallel investigations with rifampicin revealed partial cross-resistance, which was more marked in sorangicin A-resistant mutants than in rifampicin-resistant mutants.
Römmele
G
G
Research Department, Ciba-Geigy Limited, Basel, Switzerland.
Wirz
G
G
Solf
R
R
Vosbeck
K
K
Gruner
J
J
Wehrli
W
W
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003429:Cross Reactions; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects*; D018942:Macrolides; D012329:RNA, Bacterial / Q000096:biosynthesis; D012293:Rifampin / Q000494:pharmacology*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D018942:Macrolides; D012329:RNA, Bacterial; C051799:sorangicin A; D012321:DNA-Directed RNA Polymerases; D012293:Rifampin