Co-localization of calcitonin gene-related peptide- and substance P-like immunoreactivity in mucosal intra-epithelial nerves in the toad colon.
Mucosal intra-epithelial nerve terminals have been found in the colon of the toad, Bufo marinus. Co-localized in the fibres are calcitonin gene-related peptide (CGRP)-like immunoreactivity (LI) and substance P (SP)-LI. The intraepithelial nerves are likely to be terminals of primary afferent sensory neurones. Fibres with vasoactive intestinal peptide (VIP)-LI or neuropeptide Y (NPY)-LI also supply the mucosa but do not penetrate the epithelium.
Department of Zoology, University of Melbourne, Parkville, Vic., Australia.
S
S
Murphy
P B
PB
Osborne
S
S
Adamson
G
G
Campbell
D000344:Afferent Pathways / Q000166:cytology; D000818:Animals; D002024:Bufo marinus; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D003106:Colon / Q000166:cytology / Q000294:innervation*; D004847:Epithelial Cells; D005260:Female; D005455:Fluorescent Antibody Technique; D007413:Intestinal Mucosa / Q000166:cytology / Q000294:innervation*; D008297:Male; D009475:Neurons, Afferent / Q000166:cytology*; D009478:Neuropeptide Y / Q000032:analysis; D013373:Substance P / Q000032:analysis*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide