[The radiobiological characteristics of the P+ variant of Bacillus brevis var. G.--B. in relation to gramicidin S synthesis].
The radiosensitivity of P(+) variant Bacillus brevis var. G.-B. cells cultured under condition of normal and inhibited gramicidin S synthesis, antibiotically high-active strain and high radioresistant cells has been studied. It has been shown that the radioresistance of bacterial cells correlates, in general, with their antibiotic activity: the antibiotic superproduced is more radioresistant than P(+) variant, the inhibition of antibiotic synthesis by beta-phenil-beta-alanin rises a little the sensitivity of P(+) variant cells. But the radioresistant fraction of P(+) variant contains the lower antibiotic amount than the whole population. It has been concluded that the radioprotective action of gramicidin S can not be the only reason of the above-mentioned differences in radiosensitivity.
Parkhomenko
I M
IM
Zarubina
A P
AP
Romanova
N A
NA
Kossova
G V
GV
D001407:Bacillus / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D015169:Colony Count, Microbial; D003864:Depression, Chemical; D004307:Dose-Response Relationship, Radiation; D014644:Genetic Variation / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D006096:Gramicidin / Q000096:biosynthesis / Q000528:radiation effects*; D010649:Phenylalanine / Q000494:pharmacology; D011836:Radiation Tolerance; D013997:Time Factors
D006096:Gramicidin; D010649:Phenylalanine
Radiobiologicheskie osobennosti P+-varianta Bacillus brevis var. G.--B.v sviazi s sintezom gramitsidina S.