No genetic linkage detected for schizophrenia to Xq27-q28.
The hypothesis that at least a subgroup of familial cases of schizophrenia could be due to a genetic defect on the X chromosome is supported by the observation of an excess of X-chromosome aneuploidies (XXX and XXY) among populations of patients with psychosis. The distal long arm, Xq27-q28, is a candidate region where linkage has been claimed to manic-depressive disorder and a fragile site has been associated with schizophrenia spectrum disorders. The present study excluded linkage to a large part of this region using four polymorphic probes and multipoint lod-score analysis in 10 families with multiple members with schizophrenia.
Department of Psychiatry, Health Sciences Center, SUNY Stony Brook 11794.
L E
LE
Delisi
T J
TJ
Crow
K E
KE
Davies
J D
JD
Terwilliger
J
J
Ott
R
R
Ram
T
T
Flint
A
A
Boccio
D002871:Chromosome Banding; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002908:Chronic Disease; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers; D006801:Humans; D008297:Male; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D012729:Sex Chromosome Aberrations / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D014960:X Chromosome
D005819:Genetic Markers