Comparative study of the effect of CV-6209, a specific PAF-antagonist, on rat paw edema caused by different phlogogen agents.
Comparative effects of CV-6209, a potent and specific platelet activating factor (PAF) antagonist, on PAF-acether-, carrageenin-, histamine-, serotonin-, compound 48/80-, dextran-, zymosan A- and arachidonic acid-induced rat paw edema were investigated. CV-6209 has proven to be effective in PAF-induced edema, but it also showed a significant activity in other models of paw edema, except those induced by zymosan A and arachidonic acid. Other drugs tested, namely indometacin, mepyramine, methysergide and nordihydroguaiaretic acid showed a more selective inhibitory profile. These results suggest an important role of PAF in the inflammatory process caused by intraplantar injection of different phlogogenes in the rat paw.
Merlos
M
M
Research Center, J. Uriach & Cía, S.A., Barcelona, Spain.
Gómez
L A
LA
Vericat
L
L
García-Rafanell
J
J
Forn
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids; D002351:Carrageenan; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000175:diagnosis*; D006633:Histamine Antagonists; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists; D015054:Zymosan; D003189:p-Methoxy-N-methylphenethylamine
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D003911:Dextrans; D006633:Histamine Antagonists; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; D012702:Serotonin Antagonists; C053321:CV 6209; D016718:Arachidonic Acid; D003189:p-Methoxy-N-methylphenethylamine; D002351:Carrageenan; D015054:Zymosan