Antigenic comparison of Yuli and Vnukovo-32 virus strains in monkeys: specific protection by commercial antirabies preparations.
A combined vaccination schedule using commercial antirabies immunoglobulin G and experimental vaccine from strains Vnukovo-32 or Yuli beginning 2 hr before intracerebral (i.c.) challenge with a high dose of Yuli virus conferred no protection to Cercopithecus aethiops monkeys. In monkeys inoculated into lip with a middle dose of Yuli virus, administration of large amounts of antirabic IgG (up to 5000 national units, NU/kg) had a clearcut effect. The disease in Yuli virus-infected monkeys showed typical signs of acute encephalitis with lethal outcome, although one animal which developed typical encephalitis recovered as evidenced by increased virus-neutralizing antibodies in its serum. Inflammatory and degenerative lesions developed in the CNS of animals with signs of acute encephalomyelitis; their intensity was less prominent in those monkeys which underwent the combined treatment. In the cytoplasm of brain neurons of monkeys infected with Yuli virus relatively small Babes-Negri bodies with more or less apparent internal structure were detected.
Klueva
E V
EV
Institute of Poliomyelitis and Viral Encephalitides AMS SSR, Moscow, U.S.S.R.
Selimov
M A
MA
Frolova
M P
MP
Kulikova
L G
LG
Krapivina
M N
MN
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D002522:Chlorocebus aethiops; D007074:Immunoglobulin G / Q000276:immunology*; D011818:Rabies / Q000473:pathology / Q000517:prevention & control; D011819:Rabies Vaccines / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*
D000956:Antigens, Viral; D007074:Immunoglobulin G; D011819:Rabies Vaccines