Immunophenotyping of skin cells during healing of suction blister injury.
The time course of appearance and the dynamic changes of immunocompetent cells were assessed in human skin following sterile suction blister would healing. During epidermal regeneration, a local increase in Langerhans cells (LC) and the appearance of a mononuclear cell infiltrate were observed. Initially, T cells were exclusively of the T helper/inducer subtype, whereas during the later stages of the healing process an increasing number of cytotoxic/suppressor T cells (up to 30%) was observed. Keratinocytes of neither the adjacent nor the newly formed epidermis expressed HLA-DR over the course of the wound-healing process. Our results suggest that immune-competent cells such as T cells and LC may play an important role in the regulation of the wound-healing process.
Reusch
M K
MK
Department of Dermatology, University of Kiel, FRG.
Mansbridge
J N
JN
Nickoloff
B J
BJ
Morhenn
V B
VB
D001768:Blister / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D004817:Epidermis / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D015603:Keratinocytes / Q000473:pathology; D007801:Langerhans Cells / Q000473:pathology*; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D012867:Skin / Q000293:injuries* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D013602:T-Lymphocytes, Cytotoxic / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology; D013997:Time Factors; D014945:Wound Healing
D006684:HLA-DR Antigens