In vivo angiogenic activity of interleukins.
Interleukin 1 incorporated into Elvax-40 (ethylene-vinyl-acetate copolymer consisting of 40% vinyl-acetate by weight) induces a rapid and strong angiogenic stimulus when implanted in rabbit corneas at a distance of 2.5 mm from the limbus. A constant and reproducible neovascular stimulus was observed with 5 ng per implant of recombinant human interleukin 1 alpha or 100 ng per implant of recombinant human interleukin 1 beta. At these concentrations, neither tumor necrosis factor nor interleukin 2 induced any neovascular stimulus. These data are interpreted as an indication for the possible role of interleukin 1 in angiogenesis of ocular (and other) tissues. As interleukin 1 is produced by various cells, it is hypothesized that this molecule may be the "unitarian angiogenic factor."
BenEzra
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D
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Hemo
I
I
Maftzir
G
G
D000818:Animals; D003315:Cornea / Q000098:blood supply* / Q000187:drug effects; D004343:Drug Implants; D007375:Interleukin-1 / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D007378:Interleukins / Q000494:pharmacology / Q000502:physiology*; D009389:Neovascularization, Pathologic; D011145:Polyvinyls; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D004343:Drug Implants; D007375:Interleukin-1; D007376:Interleukin-2; D007378:Interleukins; D011145:Polyvinyls; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; C016438:ethylenevinylacetate copolymer