Distribution of somatostatin-immunoreactive cell bodies and fibers in the neocortex of Macaca fuscata.
The distribution of somatostatin-immunoreactive cell bodies and processes was studied in the cerebral cortex of the macaque monkey (Macaca fuscata), by applying an immunohistochemical technique with a monoclonal antibody raised against somatostatin tetradecapeptide. Many somatostatin-immunoreactive cell bodies and processes were observed in all regions of the cerebral cortex, i.e., frontal, parietal, temporal, insular, occipital, and cingulate cortices, and also in the underlying white matter. Three types of somatostatin-containing cell bodies were distinguished in the cerebral cortex. These cell bodies were distributed in layers II to VI of the cortex, and also in the underlying white matter. There were dense deposits of somatostatin-containing granular structure in layers I and II, and many somatostatin-containing processes in layers IV and V. The present observations demonstrate that in the primate neocortex somatostatin 14-containing neuronal systems are as highly developed as other prosomatostatin-derived peptides but differ from the latter systems in terms of cell morphology and fiber distribution.
Department of Psychiatry, Shiga University of Medical Sciences, Otsu, Japan.
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Iritani
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Satoh
D000818:Animals; D000911:Antibodies, Monoclonal; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000166:cytology*; D007150:Immunohistochemistry; D008251:Macaca; D009412:Nerve Fibers / Q000648:ultrastructure*; D009928:Organ Specificity; D013004:Somatostatin / Q000032:analysis*
D000911:Antibodies, Monoclonal; D013004:Somatostatin