Molecular biology of ovarian cancer.
This minireview, which due to the limitations of space cannot claim to be exhaustive, summarizes major advances in molecular biologic research on ovarian surface epithelial (adeno)carcinomas communicated approximately between the beginning of April 1990 through the end of March 1991. We focus primarily on studies of oncogenes, peptide hormone growth factors and their receptors, steroid hormone receptors, cytogenetics and flow cytometry, and resistance to therapy with cytotoxic agents.
Yale University School of Medicine, New Haven, Connecticut.
B M
BM
Kacinski
S K
SK
Chambers
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014408:Biomarkers, Tumor / Q000235:genetics; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000494:pharmacology / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D004351:Drug Resistance; D005260:Female; D005434:Flow Cytometry; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics; D009857:Oncogenes; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000532:radiotherapy; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000235:genetics; D015398:Signal Transduction
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D006133:Growth Substances; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface; D002945:Cisplatin