[Effect of adrenergic and cholinergic blocking agents on the intensity of RNA and protein biosynthesis in the liver of adult and old rats].
The uptake of labelled precursors of RNA and protein and their incorporation into corresponding macromolecules were studied in the liver of adult and old rats after pharmacological blockade of the adreno- and cholinoreceptors. The data obtained suggest direct neural regulation of transcription and translation intensity as well as the weakening of these mechanisms in aging.
Bezrukov
V V
VV
Muradian
Kh K
KhK
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004088:Dihydroergotoxine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013565:Sympatholytics / Q000494:pharmacology*
D010276:Parasympatholytics; D013565:Sympatholytics; D004088:Dihydroergotoxine; D012313:RNA; D001285:Atropine; D011433:Propranolol
Vliianie adreno- i kholinoblokatorov na intensivnost' biosinteza RNK i belka pecheni vzroslykh i starykh krys.