[DNA polymorphism: comparison of allelic frequencies obtained with two HVR probes in a population from Northeastern Brazil and in two other ethnic groups].
DNAS from 325 individuals representing 2 different populations (234 Brazilians and 91 Asiatics) were analysed for Restriction Fragment Length Polymorphisms (RFLPs). These DNAs were digested with Pvu II enzyme and successively hybridized to two HVR probes: alpha globin-3'HVR and Mucin-HVR. An allele frequency distribution was determined for each couple probe/enzyme and each ethnic groupe studied. The results were compared with frequencies observed in french population and we showed that there is no statistic significant difference between allele frequencies obtained with the couple probe/enzyme 3'HVR/Pvu II in Brazilian and French populations. We also showed that both populations studied (Brazilian and Asiatic) do not follow a Hardy-Weinberg balance.
Centre d'Hématologie et Hémothérapie du Ceara, Brésil.
J A
JA
Soares
V
V
Van Huffel
D
D
Salmon
J
J
Ruffie
C
C
Salmon
P
P
Rouger
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001208:Asia / Q000208:ethnology; D001938:Brazil; D015342:DNA Probes; D005602:France; D005787:Gene Frequency / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D015342:DNA Probes
Polymorphisme de l'ADN: comparaison des fréquences alléliques obtenues avec deux sondes HVR dans une population du Nord-Est du Brésil et dans deux autres groupes ethniques.