[The infection of mice with the influenza virus suppresses bone marrow precursor differentiation in the erythroid and granulocyte directions].
Mice (CBA X C57BL/6)F1 were inoculated intranasally with nonlethal doses of influenza A/PR/8/34 virus (500 EID50). At different intervals postinoculation, bone marrow cells were collected from them and inoculated intravenously to lethally irradiated syngeneic recipients with the purpose of determination of the histological types of colony-forming units of spleen (CFUs). On day 3 after inoculation, inhibition of CFUs differentiation in erythroid and granulocytic directions was observed, and in 7 days only granulocytic shoot of hemopoiesis was inhibited. Lymph node cells of the donors in 3 days postinoculation inhibited the colony-forming activity of bone marrow cells of intact mice with suppression of differentiation of erythrocytes and granulocytes. The possible mechanisms of influenza virus-mediated effect on the processes of bone marrow hemopoiesis are discussed.
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Lavrov
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Semenkov
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation / Q000379:methods; D002454:Cell Differentiation / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D015672:Erythroid Precursor Cells / Q000166:cytology* / Q000528:radiation effects / Q000637:transplantation; D005260:Female; D006098:Granulocytes / Q000166:cytology* / Q000528:radiation effects / Q000637:transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000528:radiation effects; D009980:Influenza A virus; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009976:Orthomyxoviridae Infections / Q000473:pathology*; D014185:Transplantation, Isogeneic
Infitsirovanie mysheĭ virusom grippa ugnetaet differentsirovku kostnomozgovykh predshestvennikov v éritroidnom i granulotsitarnom napravleniiakh.