The effect of doxazosin, urapidil and indoramin pretreatment on fever produced by E. coli lipopolysaccharide in rabbits.
1. Thermal responses to i.v. administration of doxazosin (0.75 or 1.50 mg/kg), urapidil (5.0 or 10.0 mg/kg), or indoramin (0.75 or 1.50 mg/kg) were investigated in febrile rabbits (treated with Escherichia coli lipopolysaccharide) at an ambient temperature of 19 +/- 1 degree C. 2. All these alpha 1-adrenoceptor blockers produced statistically significant antipyresis which developed as a result of inhibition of metabolic heat production and/or stimulation of heat elimination from the ear skin area or respiratory tract. 3. It appears that the antipyretic effect is a general feature of alpha 1-adrenergic receptor blockers. The possible mechanisms by which antipyresis is produced are being considered.
Department of Pharmacology, Medical Academy, Gdańsk, Poland.
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D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects; D017292:Doxazosin; D004926:Escherichia coli; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D007217:Indoramin / Q000494:pharmacology; D008070:Lipopolysaccharides; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D011224:Prazosin / Q000031:analogs & derivatives / Q000494:pharmacology; D011817:Rabbits
D000317:Adrenergic alpha-Antagonists; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D010879:Piperazines; D007217:Indoramin; C015568:urapidil; D017292:Doxazosin; D011224:Prazosin