Impaired interleukin 2 production by spleen cells from mice infected with human adenovirus.
Spleen cells from mice infected with human adenovirus type 6 (Ad6) showed defective interleukin 2 (IL2) production 3-5 days after the infection. The response of spleen cells to exogenous IL 2 was also deficient. The impaired capacity of concanavalin A--(Con A)-activated spleen cells from Ad6--infected mice to utilize IL 2 seemed to be related to the depressed capacity of the infected splenocytes to express IL 2 receptors. The immunologic dysfunction following infection with Ad6 may be a consequence of deficiencies in both the elaboration of and response to IL 2.
Institute of Microbiology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
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Berencsi
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Bakay
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Béládi
D000260:Adenoviruses, Human / Q000502:physiology*; D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis* / Q000187:drug effects; D013154:Spleen / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism* / Q000382:microbiology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D003208:Concanavalin A