Serum levels of circulating intercellular adhesion molecule 1 in human malignant melanoma.
Current reports have suggested a role for intracellular adhesion molecule 1 (ICAM-1) in the progression of human malignant melanoma and other cancers. Stage I, II, and III patients with histologically diagnosed malignant melanoma had significantly increased serum levels of circulating ICAM-1 (cICAM-1) and a striking increase in the incidence of positive sera. In Stage II and III patients, the level of cICAM-1 was inversely correlated with survival. Patients with elevated levels of serum cICAM-1 (greater than 2 SD units above control mean) had a significantly shorter mean survival. We suggest that elevated levels of serum cICAM-1 may be of diagnostic and prognostic importance in patients with malignant cutaneous melanoma.
Department of Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877.
R
R
Harning
E
E
Mainolfi
J C
JC
Bystryn
M
M
Henn
V J
VJ
Merluzzi
R
R
Rothlein
D000328:Adult; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000401:mortality; D008875:Middle Aged; D011379:Prognosis
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1