[Current concepts of the role of the thymol test in the laboratory diagnosis of viral hepatitis A].
Current notions on the role of the thymol test (TT) in the diagnosis of viral hepatitis A are discussed. Changes in TT results over the course of the disease are presented, starting from the incubation period up to the second-third week; these values are compared to those of hepatitis A specific markers. The earliest TT shifts in hepatitis A are detectable already 15-18 days before the first clinical manifestations, when this parameter surpasses the upper threshold of the range of normal values. The incubation period TT values are 6.9-8.4 U S-H, those during the 3 weeks of the acute period are 9.1-9.7 U S-H. This test earlier reacts to liver inflammation than alanine aminotransferase (a hepatic enzyme) measurement, which fact recommends TT for active early detection of hepatitis A patients in epidemic foci in collective bodies. One more TT advantage over the detection of hepatitis A specific markers in epidemic foci is that it permits the diagnosis of hepatitis whatever its etiology.
Khokhlov
D T
DT
Malyshev
V V
VV
Ogarkov
P I
PI
D000410:Alanine Transaminase / Q000097:blood; D000956:Antigens, Viral / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D005243:Feces / Q000032:analysis; D006506:Hepatitis A / Q000175:diagnosis*; D006508:Hepatitis Antibodies / Q000097:blood; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007565:Jaundice / Q000175:diagnosis; D013943:Thymol; D013997:Time Factors
D000956:Antigens, Viral; D015415:Biomarkers; D006508:Hepatitis Antibodies; D007075:Immunoglobulin M; D013943:Thymol; D000410:Alanine Transaminase
Sovremennye predstavleniia o roli timolovoĭ proby v laboratornoĭ diagnostike virusnogo gepatita A.