Structure and stereochemistry of brianolide, a new antiinflammatory diterpenoid from the Okinawan gorgonian Briareum sp.
Brianolide (1), a new antiinflammatory diterpenoid of the briarein class, possessing a beta substituent at C-12 (R), has been isolated from the Okinawan gorgonian Briareum sp. Its structure has been established from spectral data in conjunction with a single crystal X-ray analysis.
Kobayashi
J
J
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Cheng
J F
JF
Nakamura
H
H
Ohizumi
Y
Y
Tomotake
Y
Y
Matsuzaki
T
T
Grace
K J
KJ
Jacobs
R S
RS
Kato
Y
Y
Brinen
L S
LS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification; D003063:Cnidaria; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; C069323:brianolide