Heterogeneity in human soluble guanylate cyclase due to alternative splicing.
Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing.
Department of Pharmacology, Umeå University, Sweden.
V
V
Chhajlani
P A
PA
Frändberg
J
J
Ahlner
K L
KL
Axelsson
J E
JE
Wikberg
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D006162:Guanylate Cyclase / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D009841:Oligonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D012326:RNA Splicing; D051381:Rats; D016415:Sequence Alignment; D012995:Solubility
D009841:Oligonucleotides; D006162:Guanylate Cyclase