Reversible thyroid dysfunction during treatment with GM-CSF.
To investigate whether autoimmunity against thyroid antigens is induced or exacerbated by granulocyte-macrophage colony-stimulating factor, thyroid function and thyroid autoantibodies were studied in 14 patients with advanced breast cancer and 11 with soft-tissue sarcoma who received several cycles of doxorubicin and cyclophosphamide plus GM-CSF 250 micrograms/m2 intravenously daily for 10 days in every 21 day cycle. All patients had normal thyroid function before treatment. In 2 patients with pre-existing thyroid antibodies, thyroid dysfunction developed but disappeared after cessation of GM-CSF. No other autoimmune abnormalities appeared. Stimulation of antigen-presenting cells by GM-CSF may bring about this phenomenon.
Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands.
K
K
Hoekman
B M
BM
von Blomberg-van der Flier
J
J
Wagstaff
H A
HA
Drexhage
H M
HM
Pinedo
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*; D015551:Autoimmunity / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000276:immunology; D004334:Drug Administration Schedule; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000188:drug therapy / Q000276:immunology; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000276:immunology; D013963:Thyroid Hormones / Q000276:immunology; D013966:Thyroiditis / Q000139:chemically induced / Q000276:immunology / Q000503:physiopathology*
D001323:Autoantibodies; D013963:Thyroid Hormones; D016178:Granulocyte-Macrophage Colony-Stimulating Factor