Hematological and biochemical studies in children with Down syndrome.
Eighty-three children with Down syndrome were submitted to hematological and biochemical studies; 69 normal children were included as controls. The variables analyzed were: HbF, HbA2, serum B12 vitamin (B12), folates, total iron and iron binding capacity, hematic cytology, and the red blood cell enzymes adenosine deaminase (ADA), glucose-6-phosphate dehydrogenase (G6PD) and superoxide dismutase (SOD). The most relevant results were: macrocytosis, normal leucocytes, HbF, B12 and folates, as well as high levels of the enzymes ADA and G6PD. An indirect association between macrocytosis, ADA and G6PD is discussed.
División de Genética, Hospital de Especialidades del Centro Médico de Occidente, IMSS, Guadalajara, Jalisco, Mexico.
B
B
Ibarra
F
F
Rivas
C
C
Medina
M E
ME
Franco
F
F
Romero-García
C
C
Enriquez
M
M
Galarza
A
A
Hernández-Córdova
T
T
Hernández
D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood*; D004798:Enzymes / Q000097:blood; D004909:Erythrocyte Indices; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006443:Hemoglobin A2 / Q000032:analysis; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood; D008297:Male; D014815:Vitamins / Q000097:blood
D004798:Enzymes; D014815:Vitamins; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin; D007501:Iron