[The effect of metabolic agents on the antiarrhythmic activity of novocainamide and acetylnovocainamide].
The effects of potassium malate and sodium succinate on the antiarrhythmic activity of novocainamide and acetylnovocainamide during modelling of chlor-calcium-induced arrhythmia as well as in disorders of cardiac rhythm during modelling of pituitrin-isadrine-induced myocardial infarction were studied. The metabolic agents were found to increase the effectiveness of acetylnovocainamide and the toxicity of novocainamide. To interpret the specific features of the mechanism of the anti-arrhythmic action of the compounds there was studied their ability to form complexes with components of biomembranes and ions of biometals.
E G
EG
Beregovaia
N A
NA
Gorchakova
T G
TG
Samarskaia
V V
VV
Dunaev
I S
IS
Chekman
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D002122:Calcium Chloride; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007545:Isoproterenol; D007928:Lethal Dose 50; D008293:Malates / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy; D010909:Pituitary Hormones, Posterior; D011188:Potassium / Q000627:therapeutic use; D011342:Procainamide / Q000031:analogs & derivatives* / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates / Q000627:therapeutic use*; D019802:Succinic Acid
D000889:Anti-Arrhythmia Agents; D008293:Malates; D010909:Pituitary Hormones, Posterior; D013386:Succinates; C030298:malic acid; D019802:Succinic Acid; D011342:Procainamide; D007545:Isoproterenol; D002122:Calcium Chloride; D011188:Potassium
Vliianie metaboliticheskikh sredstv na antiaritmicheskuiu aktivnost' novokainamida i atsetilnovokainamida.