Noradrenergic innervation of human inferior olivary complex.
Antisera to human dopamine beta-hydroxylase (DBH) was used to stain noradrenergic axons in the inferior olivary complex (IOC) of human controls. A modest plexus of thin, beaded, immunoreactive fibers was present in all subdivisions of the IOC, and many fibers coursed in the rostrocaudal axis. This noradrenergic plexus is similar to that of monkey, provides complementary evidence to reports of beta-adrenergic receptors in human IOC, and supports the concept of noradrenergic projections to IOC.
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
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D000328:Adult; D000368:Aged; D004299:Dopamine beta-Hydroxylase / Q000276:immunology; D005453:Fluorescence; D006801:Humans; D007150:Immunohistochemistry; D008526:Medulla Oblongata / Q000502:physiology; D008875:Middle Aged; D009638:Norepinephrine / Q000502:physiology*; D009847:Olivary Nucleus / Q000502:physiology*; D013194:Staining and Labeling
D004299:Dopamine beta-Hydroxylase; D009638:Norepinephrine