Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26----q28.
Annexin V is a member of a new family of calcium-dependent phospholipid-binding proteins. It has been previously isolated as placental anticoagulant protein I, inhibitor of blood coagulation, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4, and anchorin CII. The human gene encoding annexin V (ANX5) was localized to 4q26----q28 by in situ hybridization with a cDNA probe and polymerase chain-reaction (PCR) analysis of a human x hamster hybrid cell panel. The regional localization to 4q26----q28 was supported by Southern-blot analysis of a human cell line with a deletion in 4q23----q27. This localization overlaps but differs slightly from the previous assignment of ANX5 to 4q28----q32. Digestion with PvuII and TaqI identified polymorphisms at the ANX5 locus; the PvuII polymorphism could also be detected by PCR analysis.
Department of Laboratory Medicine, University of Washington, Seattle 98195.
J F
JF
Tait
D A
DA
Frankenberry
R
R
Shiang
J C
JC
Murray
D A
DA
Adler
C M
CM
Disteche
D000818:Animals; D017304:Annexin A5; D001483:Base Sequence; D014408:Biomarkers, Tumor / Q000235:genetics; D015139:Blotting, Southern; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011257:Pregnancy Proteins / Q000235:genetics*
D017304:Annexin A5; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; D011257:Pregnancy Proteins