The gene for retinal rod 33-kDa protein is on mouse chromosome 1, near Lamb2.
A water-soluble protein (called "33-kDa protein") that exhibits light-dependent phosphorylation has been shown to be a major protein of mammalian rod photoreceptors. Although the function of this protein is unknown, it has been implicated in the biochemical cascade mediating the rod visual response. Using a retinal cDNA from the rat and somatic cell hybrids, we have mapped the gene corresponding to this protein to mouse Chromosome 1 and, by analyzing the progeny of an intersubspecific backcross, have positioned it near Lamb2 (the beta 2 chain of laminin). We have designated the gene Rpr-1 (rod photoreceptor protein-1).
Jules Stein Eye Institute, UCLA School of Medicine.
M
M
Danciger
C A
CA
Kozak
T
T
Abe
T
T
Shinohara
D B
DB
Farber
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D015342:DNA Probes; D005136:Eye Proteins / Q000235:genetics*; D008040:Genetic Linkage; D051379:Mice / Q000235:genetics*; D010786:Photoreceptor Cells / Q000737:chemistry; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping
D015342:DNA Probes; D005136:Eye Proteins; D004247:DNA