[Central adrenergic agonist agents as representatives of a new class of nonopiate analgesics].
The problem of nonopiate analgesia is briefly discussed in the historical aspect. The mechanism of the analgesic effect of adrenopositive compounds and its implementation through different populations of alpha-adrenoreceptors at supra- and segmental levels of the brain, the advantages of clopheline over traditional narcotic analgesics are grounded. The data confirming the clinical effectiveness of clopheline in pain syndromes are presented, the perspectives of the practical use of clopheline-like and other adrenopositive agents are discussed.
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Zaĭtsev
D000322:Adrenergic Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D000698:Analgesia / Q000379:methods; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D006801:Humans
D000322:Adrenergic Agonists; D000700:Analgesics
Tsentral'nye adrenopozitivnye sredstva kak prestaviteli novogo klassa neopiatnykh anal'getikov.