Level and composition of fetal hemoglobin expression in normal newborn babies are not dependent on beta cluster DNA haplotype.
Interindividual variations in the level and composition of fetal hemoglobin observed in 604 cord blood samples from normal white and nonwhite newborns, unlike those in adults, are not dependent on beta gene cluster DNA haplotype. The data suggest that the mechanism(s) involved in the neonatal expression of Hb F is distinct from that at the adult stage.
ICGM, C.H.U. Cochin, Paris, France.
J
J
Rochette
C
C
Dodé
F
F
Leturcq
R
R
Krishnamoorthy
D004247:DNA / Q000235:genetics*; D005319:Fetal Hemoglobin / Q000378:metabolism*; D006239:Haplotypes; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D005810:Multigene Family
D004247:DNA; D005319:Fetal Hemoglobin