Progressive hypervolemia despite hypoproteinemia and massive edema formation in rats with nephrotoxic serum nephritis.
Blood volume and whole kidney and single nephron function were evaluated 2 and 10 days after nephrotoxic serum nephritis (NSN) induction in Wistar rats. Progressive proteinuria, hypervolemia and edema were observed in NSN rats. Sodium retention was associated with a progressive depression of single nephron glomerular filtration rate and elevated fractional tubular reabsorption rates. Since hypervolemia rather than hypovolemia was observed in this study, edema formation must have been a consequence of intrarenal rather than extrarenal phenomena.
Fujihara
C K
CK
Nephrology Unit, University of São Paulo Medical School, Brazil.
Marcondes
M
M
Zatz
R
R
D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume / Q000502:physiology*; D004487:Edema / Q000209:etiology*; D005919:Glomerular Filtration Rate; D007019:Hypoproteinemia / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology; D008297:Male; D009393:Nephritis / Q000139:chemically induced / Q000503:physiopathology*; D009399:Nephrons / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000032:analysis
D012709:Serum Albumin