Marker rhythmometry with macrophage-colony stimulating factor (M-CSF).
In a patient with a debulked müllerian adenocarcinoma involving the ovary, an elevated serum concentration of macrophage-colony stimulating factor (M-CSF) (5.3 ng/ml) was lowered into the range of the age- and gender-matched controls by a 24-hour infusion of 135 mg/m2 of taxol, as was a Ca125 of 1480 U/ml by three such taxol courses given at 3-week intervals (to 14 U/ml). A downward trend of M-CSF in serum with an about-14-hour ultradian modulation during the first chemotherapy course resembles that of the concomitantly assessed Ca125. A decreasing trend modulated by an about-half-weekly component is found in M-CSF of fractionated urines collected at spontaneous voidings around the clock for 5 days. M-CSF may serve as a chronobiologic marker for optimizing, on an individualized basis, 1) the infradian scheduling of chemotherapy courses and 2) the ultradian-circadian within-course time patterns. Timing based on markers of the anticancer effect aims at teh as-yet unattained transfer from rodent to human of cancer cures that were not previously feasible without chronobiologic considerations. This goal can be pursued with M-CSF as well as Ca125 and UGP as possibly complementary chronobiologic markers in a chronotherapy trial with taxol in humans.
Elg
S
S
University of Minnesota, Minneapolis.
Halberg
E
E
Ramakrishnan
S
S
Cornélissen
G
G
Haus
E
E
Nicolau
G
G
Carson
L
L
Twiggs
L
L
Long
H J
HJ
Halberg
F
F
D000368:Aged; D000470:Alkaloids / Q000627:therapeutic use; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood* / Q000652:urine; D006063:Chorionic Gonadotropin / Q000652:urine; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood* / Q000652:urine; D009373:Neoplasms, Germ Cell and Embryonal / Q000097:blood / Q000188:drug therapy / Q000652:urine; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy / Q000652:urine; D017239:Paclitaxel; D010446:Peptide Fragments / Q000652:urine; D010507:Periodicity
D000470:Alkaloids; D015295:Antigens, Tumor-Associated, Carbohydrate; D000972:Antineoplastic Agents, Phytogenic; D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; C063554:urinary gonadotropin fragment; D016173:Macrophage Colony-Stimulating Factor; D017239:Paclitaxel