Release of endothelin from cultured bovine endothelial cells.
Recently discovered endothelin is a powerful vasoconstrictor of vascular smooth muscle in vitro, which also profoundly affects the mechanical function of the heart. An increased level of plasma endothelin in patients with acute myocardial infarction suggests the enhanced release of endothelin from vascular endothelium under pathophysiological conditions of the heart. The reperfusion of ischemic myocardium is associated with the activation of polymorphonuclear leukocytes (PMN) generating oxygen-derived free radicals (OFR), as well as, enhanced responsiveness of myocardial alpha 1-adrenergic receptor. Both OFR and catecholamines are implicated in the modulation of release of endothelium-derived peptides.
Department of Surgery, University of Connecticut Health Center, Farmington 06030-9984.
M R
MR
Prasad
R M
RM
Jones
D L
DL
Kreutzer
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D016232:Endothelins / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D005609:Free Radicals; D006878:Hydroxides / Q000378:metabolism; D017665:Hydroxyl Radical
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D016232:Endothelins; D005609:Free Radicals; D006878:Hydroxides; D017665:Hydroxyl Radical