RNA synthesis by hepatocytes isolated from adult and senescent Wistar rat liver.
The rates of synthesis of total RNA, poly(A)+ RNA and poly(A)+ RNA are decreased by 41, 49 and 42%, respectively, in hepatocytes isolated from senescent (25 months) compared to adult (12 months) female Wistar rats. Results from transcription run-on assays indicate that an impaired ability to initiate transcription largely accounts for the decreased synthesis of RNA by the senescent hepatocytes.
Park
G H
GH
Department of Physiology and Biophysics, University of Illinois, Urbana.
Buetow
D E
DE
D000375:Aging / Q000502:physiology*; D000818:Animals; D012321:DNA-Directed RNA Polymerases / Q000096:biosynthesis*; D005260:Female; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014158:Transcription, Genetic / Q000502:physiology
D012313:RNA; D012321:DNA-Directed RNA Polymerases