[Measurement of intestinal permeability in Crohn's disease, ulcerative colitis, sprue and idiopathic hyperamylasemia using polyethyleneglycol-400].
We investigated intestinal permeability in healthy adult volunteers, and in patients with Crohn's disease, ulcerative colitis, idiopathic sprue and idiopathic hyperamylasemia by oral administration of 10 g low molecular weight polyethylene glycol (PEG-400) and quantitation of its renal excretion over the subsequent 6 hours by high performance liquid chromatography (gel permeation HPLC). The mean amount of PEG-400 excreted during the first 6 hours by the 12 patients with Crohn's disease (3.1 +/- 0.3 g, mean +/- SE) and the 8 patients with ulcerative colitis (2.6 +/- 0.3 g) was not significantly different from the amount excreted by the 24 healthy volunteers (2.9 +/- 0.1 g). The 3 patients with idiopathic sprue excreted significantly less (1.4 +/- 0.3 g, p less than 0.05) and the 3 patients with idiopathic hyperamylasemia significantly more (4.0 +/- 0.4 g, p less than 0.05) than the healthy controls. In conclusion, no alteration of intestinal permeability could be demonstrated in patients with Crohn's disease or ulcerative colitis. However, intestinal permeability was decreased in patients with idiopathic sprue and increased in those with idiopathic hyperamylasemia.
Departement für Innere Medizin, Universitätsspital Zürich.
U
U
Zellweger
A U
AU
Freiburghaus
R
R
Münch
C
C
Meyenberger
H
H
Bühler
R
R
Ammann
D000328:Adult; D000681:Amylases / Q000097:blood; D002446:Celiac Disease / Q000503:physiopathology; D002463:Cell Membrane Permeability; D003093:Colitis, Ulcerative / Q000503:physiopathology; D003424:Crohn Disease / Q000503:physiopathology; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000503:physiopathology; D008875:Middle Aged; D011092:Polyethylene Glycols
D011092:Polyethylene Glycols; D000681:Amylases
Messung der Darmpermeabilität bei Morbus Crohn, Colitis ulcerosa, Sprue und idiopathischer Hyperamylasämie mit Polyethylenglykol-400.