Genetic analysis of autoimmune type 1 diabetes mellitus in mice.
Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11, outside the chromosome 17 major histocompatibility complex. A genetic map of the mouse genome, analysed using the polymerase chain reaction, has been assembled specifically for the study. On the basis of comparative maps of the mouse and human genomes, the homologue of Idd-3 may reside on human chromosomes 1 or 4 and Idd-4 on chromosome 17.
Nuffield Department of Surgery, John Radcliffe Hospital, Headington, Oxford, UK.
J A
JA
Todd
T J
TJ
Aitman
R J
RJ
Cornall
S
S
Ghosh
J R
JR
Hall
C M
CM
Hearne
A M
AM
Knight
J M
JM
Love
M A
MA
McAleer
J B
JB
Prins
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics*; D002874:Chromosome Mapping; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D007515:Islets of Langerhans / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D010195:Pancreatitis / Q000235:genetics / Q000473:pathology; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid