Lack of bcr rearrangement in juvenile chronic myeloid leukemia.
Juvenile chronic myeloid leukemia (JCML) is an unusual subtype of children's leukemia, characterized by unique clinical presentation. Recent studies revealed several biological features, distinguishing from those observed in adult type chronic myeloid leukemia (ACML). The majority of ACML cases are characterized by the presence of an hybrid bcr-abl rearranged gene. In an effort to elucidate the molecular basis of this unusual leukemia we looked for bcr rearrangement in six JCML cases. No bcr rearrangement was identified in any of the analyzed samples. Together with previous studies from JCML cases, JCML has a different mechanism of leukomogenesis from ACML.
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
A
A
Toren
M
M
Mandel
N
N
Amariglio
Y
Y
Hakim
F
F
Brok-Simoni
G
G
Rechavi
Y
Y
Neumann
B
B
Ramot
D015139:Blotting, Southern; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D015321:Gene Rearrangement; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000382:microbiology; D012150:Polymorphism, Restriction Fragment Length; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051562:Proto-Oncogene Proteins c-bcr
D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr