Sequence comparison between the fusion protein of human and bovine respiratory syncytial viruses.
The nucleotide sequence was determined for the fusion (F) protein-coding mRNA of the bovine respiratory syncytial virus (strain RB 94) and the amino acid sequence of the F protein was deduced for comparison with the sequence of human respiratory syncytial virus subtypes A and B (RSS-2 and 18537 strains). The human and bovine RS virus F proteins (excluding the cleaved signal peptide) share 83 to 84% homology. The greatest divergence occurred within the F2 subunit in the region preceding the cleavage activation site.
Walravens
K
K
Laboratoire de Microbiologie et d'Immunologie, Faculté Universitaire Notre Dame de la Paix, Namur, Belgium.
Kettmann
R
R
Collard
A
A
Coppe
P
P
Burny
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D003001:Cloning, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D021382:Protein Sorting Signals / Q000235:genetics; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000235:genetics; D012136:Respiratory Syncytial Viruses / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014709:Vero Cells; D014760:Viral Fusion Proteins / Q000235:genetics*
D021382:Protein Sorting Signals; D012333:RNA, Messenger; D014760:Viral Fusion Proteins; D012313:RNA