[Antimicrobial and hemolytic activities of gradex].
Gradex is a polymer preparation resulting from formation of covalent bonds between the molecules of gramicidin S, a polypeptide antibiotic, and dextran, a polymeric carrier. Antimicrobial and hemolytic activities of gradex were studied. It was shown that the antimicrobial activity of gradex was due to the presence of gramicidin S in its composition. The activity level was lower than that of gramicidin S. It was also found that the gradex reduced form in concentrations up to 300 micrograms/ml had practically no hemolytic effect against human erythrocytes. The reduced form of gradex is promising for development of an artificial ++anti-brucellosis vaccine.
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ZM
Petrykina
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Polin
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Goriainov
D001407:Bacillus / Q000187:drug effects*; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D004337:Drug Carriers; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D006096:Gramicidin / Q000008:administration & dosage / Q000494:pharmacology* / Q000031:analogs & derivatives; D006461:Hemolysis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D008837:Micrococcus / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*
D003911:Dextrans; D004337:Drug Carriers; D004338:Drug Combinations; C066571:gradex; D006096:Gramicidin
Antimikrobnaia i gemoliticheskaia aktivnost' gradeksa.