Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats.
The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg-1/h-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7%) at the level of the 1.87 nmol/kg-1/h-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg-1/h-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.
Dept. of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112.
R V
RV
Yagci
N
N
Alptekin
W J
WJ
Rossowski
A
A
Brown
D H
DH
Coy
A
A
Ertan
D000818:Animals; D004305:Dose-Response Relationship, Drug; D019004:Galanin; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D009479:Neuropeptides; D010455:Peptides; D019004:Galanin; D010418:Pentagastrin