Effects of ulinastatin in experimental acute arterial occlusion in rats.
The effects of ulinastatin (human urinary trypsin inhibitor, UTI) were studied in experimental acute arterial occlusion in rats. The experimental model comprised concurrent cross-clamping of the abdominal aorta and bilateral femoral arteries for 4 hours. Blood was sampled for measurement of the enzymes 2 hours after release of the clamps. The rats were grouped according to method of infusing UTI and/or physiologic saline solution. When UTI was infused continuously from the start of clamping, the plasma creatine phosphokinase and plasma beta-glucuronidase levels were significantly lower than in the control rats (p less than 0.05). The results suggest that UTI prevents the destruction of the lysosomal membrane in acute arterial occlusion.
Department of Cardiovascular Surgery, Kyoto University Faculty of Medicine, Japan.
K
K
Nishimura
K
K
Kumada
R
R
Okamoto
T
T
Ban
D000208:Acute Disease; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000201:enzymology; D003402:Creatine Kinase / Q000097:blood; D005966:Glucuronidase / Q000097:blood; D006023:Glycoproteins / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D011897:Random Allocation; D051381:Rats; D014361:Trypsin Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*
D006023:Glycoproteins; D014361:Trypsin Inhibitors; D003402:Creatine Kinase; D005966:Glucuronidase; C028665:urinastatin