Hyperamylasemia associated with progression of a serous surface papillary carcinoma.
A 60-year-old white woman had a bilateral salpingo-oophorectomy, hysterectomy, and omentectomy for serous surface papillary carcinoma. Combination chemotherapy consisting of cisplatin, doxorubicin, and cyclophosphamide was given for 1 year, but was followed by relapse 4 months after completion. This relapse was associated with hyperamylasemia ranging from 2400 IU/liter in the early phase of relapse to 5800 IU/liter in the preterminal phase. While hyperamylasemia has been previously described in serous ovarian cystadenocarcinoma, to our knowledge this is the first report in a patient with serous surface papillary carcinoma. This marker may help in distinguishing the latter from malignant mesothelioma of the peritoneum since this is often an extremely difficult differential diagnosis.
St. James's Hospital, Dublin, Ireland.
T
T
O'Riordan
E
E
Gaffney
V
V
Tormey
P
P
Daly
D000681:Amylases / Q000097:blood*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000175:diagnosis / Q000201:enzymology*; D008854:Microscopy, Electron; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000473:pathology
D000681:Amylases