Immunohistochemical study of granular cell tumors of the neurohypophysis.
Six granular cell tumors (GCT) of the neurohypophysis were studied by immunohistochemical techniques. They were all labeled by peanut lectin (Arachis hypogaea) and three showed reactivity for S-100 protein. Unlike extracranial GCT, neuron specific enolase (NSE), myelin basic protein (MBP) and vimentin were not detected in the tumor cells. Glial fibrillary acidic protein (GFAP), keratin and desmin were also not observed. On the other hand, some showed reactivity for alpha-1-antitrypsin (AAT), alpha-1-antichymotrypsin (AAC) and cathepsin B. These results suggest that neurohypophysial GCT have some features different from extracranial GCT and that they may not be derived from Schwann cells.
Bluestone Laboratory, Department of Pathology, Montefiore Medical Center, Bronx, NY 10467.
H
H
Nishioka
K
K
Ii
J F
JF
Llena
A
A
Hirano
D000328:Adult; D000368:Aged; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins; D008297:Male; D008875:Middle Aged; D019887:Peanut Agglutinin; D010904:Pituitary Gland, Posterior / Q000473:pathology; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D037102:Lectins; D019887:Peanut Agglutinin; D009418:S100 Proteins; D000515:alpha 1-Antitrypsin