Modulation of MHC antigen expression by viruses and oncogenes.
It is becoming increasingly clear that regulation of MHC antigen expression by viruses and oncogenes, leading to either immune evasion or autoimmunity, is widespread and important in disease. At a recent meeting*, which brought together workers interested in tumour immunology, viral infection and the MHC, a number of mechanisms for the regulation of MHC antigen expression were revealed and the importance of balanced expression of MHC gene products to effective immunity was underlined.
Maudsley
D J
DJ
Dept of Biological Sciences, University of Warwick, Coventry, UK.
Pound
J D
JD
D000818:Animals; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002472:Cell Transformation, Viral; D016207:Cytokines / Q000502:physiology; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D015967:Gene Expression Regulation, Viral; D006680:HLA Antigens / Q000096:biosynthesis / Q000235:genetics; D006649:Histocompatibility Antigens / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex; D009857:Oncogenes; D009858:Oncogenic Viruses / Q000235:genetics / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology*; D018406:Virus Physiological Phenomena; D014780:Viruses / Q000235:genetics
D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D016207:Cytokines; D006680:HLA Antigens; D006649:Histocompatibility Antigens