[Precancerous and cancerous lesions and their gamma-glutamyl transpeptidase expression in 3-methylcholanthrene-induced lung carcinogenesis in rats].
Lung precancerous and cancerous lesions were induced in Wistar rats by one intrabronchial injection of 3-methylcholanthrene (3-MC). The incidences of atypical hyperplasia of bronchiolar epithelium, adenoid hyperplasia or adenomas, and squamous cell carcinoma were 88.2% (15/17), 70.6% (12/17) and 17.7% (3/17) respectively by the 30th day after 3-MC treatment, and 83.3% (15/18), 23.5% (4/17) and 38.9% (7/18) by the 60th day. Positive expression of gamma-glutamyltranspeptidase (GGT) was identified histochemically in all of the above precancerous lesions and carcinomas. GGT might be used as a marker of precancerous and cancerous lesions of the lung.
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Institute of Oncology, Beijing.
D000236:Adenoma / Q000139:chemically induced / Q000201:enzymology; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000201:enzymology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene; D011230:Precancerous Conditions / Q000139:chemically induced / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D014408:Biomarkers, Tumor; D008748:Methylcholanthrene; D005723:gamma-Glutamyltransferase