Adoptive transfer of viable motheaten pathology in sublethally irradiated beige recipient mice.
B6 viable motheaten (mev) mice are short-living autoimmune and immunodeficient mice. Most of the mev pathology is transferable into the B6 beige (bg) irradiated mouse by injection of mev haematopoietic cells. Indeed there is a rapid establishment of lung damage, thymus aplasia, inflammation and necrosis of peripheral joints, an increase of serological IgM concentrations and autoantibody levels as well as a rapid death. This mev-type pathology can be again obtained by transferring haematopoietic cells of these [mev----bg] chimeras into other irradiated bg mice, although the appearance of these serological and phenotypical symptoms seems to be more and more delayed when doing cascade transfers.
Kuntz
L
L
Laboratoire d'Immunologie, Université Louis Pasteur, Strasbourg, France.
Montecino-Rodriguez
E
E
Jachez
B
B
Roman
D
D
Loor
F
F
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007958:Leukocyte Count; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera / Q000276:immunology; D013154:Spleen / Q000637:transplantation
D007074:Immunoglobulin G; D007075:Immunoglobulin M