Changes in populations of immune effector cells during the course of haemorrhagic fever with renal syndrome.
To characterize the immune response in haemorrhagic fever with renal syndrome, serial changes in immune effector cells were measured in 14 patients. Significant findings included initial elevations of all major leucocyte populations, increases in suppressor T cells and B cells, decreases in helper/suppressor cell ratios, and a dramatic increase in activated T cells. These changes were most marked in severely ill patients. Changes reverted to normal over approximately one week.
Medical Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
R M
RM
Lewis
H W
HW
Lee
A F
AF
See
D B
DB
Parrish
J S
JS
Moon
D J
DJ
Kim
T M
TM
Cosgriff
D000328:Adult; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D008218:Lymphocytosis / Q000276:immunology; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology