Prolonged and selective induction of Fos-related antigen(s) in striatal neurons after 6-hydroxydopamine lesions of the rat substantia nigra pars compacta.
Unilateral 6-hydroxydopamine (6-OHDA) lesions of the rat substantia nigra lead to a large widespread and long-lasting (greater than 3 months) increased expression of Fos-related antigen(s) (FRAs) in striatal neurons ipsilateral to the side of the lesion. However, Fos and Jun expression were only very slightly increased in a few scattered neurons in the dopamine-denervated striatum. These results demonstrate that FRAs are induced long-term in striatal neurons following dopamine-depletion. This increased production of FRAs may be related to neuropeptide and/or D2 dopamine receptor upregulation that also occurs in the dopamine-denervated striatum.
Department of Pharmacology, School of Medicine, University of Auckland, New Zealand.
M
M
Dragunow
J D
JD
Leah
R L
RL
Faull
D000818:Animals; D016762:Genes, fos / Q000187:drug effects*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D016627:Oxidopamine / Q000633:toxicity*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013238:Stereotaxic Techniques; D013378:Substantia Nigra / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D016760:Proto-Oncogene Proteins c-fos; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase