Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation.
Severe interstitial pneumonitis in 2 marrow-transplant recipients was associated with human herpesvirus-6 (HHV-6) infection. The virus was repeatedly detected in respiratory specimens from 1 patient, and HHV-6-infected cells were shown in lung tissue from both patients by immunohistochemical staining. The infected cells were primarily intra-alveolar macrophages, although infected lymphocytes were seen. HHV-6 should be considered as a cause of unexplained lung disease in marrow-transplant recipients and other immunocompromised patients.
Carrigan
D R
DR
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226.
Drobyski
W R
WR
Russler
S K
SK
Tapper
M A
MA
Knox
K K
KK
Ash
R C
RC
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D005260:Female; D006566:Herpesviridae Infections / Q000209:etiology* / Q000473:pathology; D015654:Herpesvirus 6, Human; D006801:Humans; D007108:Immune Tolerance; D007150:Immunohistochemistry; D008297:Male; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology