Production of tumor necrosis factor alpha and interleukin 1 beta by peripheral blood mononuclear cells from chronic hepatitis type C patients during interferon therapy.
To elucidate the role of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) in chronic hepatitis type C (CH(C], TNF alpha and IL-1 beta released from peripheral blood mononuclear cells were measured in 6 CH(C) patients before and during interferon therapy. During the therapy, TNF-alpha levels were significantly high in two patients whose serum ALT levels turned normal, while IL-1 beta levels did not show significant change. These results suggest that TNF-alpha takes part in improvement of CH(C).
Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai.
Y
Y
Ueno
H
H
Suzuki
K
K
Kobayashi
M
M
Miura
T
T
Toyota
D006526:Hepatitis C / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D007375:Interleukin-1 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D000637:Transaminases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons; D000637:Transaminases