The variability of orocecal transit time evaluated by the salicylazosulphapyridine/sulphapyridine method.
The inter- and intrasubject variability of the orocecal transit time assessed by the salicylazosulphapyridine/sulphapyridine test was examined. Nine healthy males attended on 3 occasions. Between-days comparison gives highly reproducible transit times for the subjects considered as a group (median values and their 95%-confidence limits): 4.0 (3.5-4.5), 4.5 (3.5-5.0), and 4.5 (3.0-4.5) hours, respectively. Fifty-nine per cent of the individual transit times amounts to 4.0 or 4.5 hours. Within subject comparison revealed marked differences for 4 of the volunteers. The maximum between-days differences observed were 1.0 (3 subjects) and 2.5 hours, respectively. Similar results of variability become evident regarding the area under the sulphapyridine concentration-time curves. In conclusion, it appears reasonable to use this method in assessing e.g. the effects of drugs on the transit time in crossover studies.
Institute of Clinical Pharmacology, Medical School Carl Gustav Carus, Dresden, Germany.
T
T
Gramatté
B
B
Terhaag
D000328:Adult; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D008297:Male; D013427:Sulfapyridine / Q000097:blood; D012460:Sulfasalazine / Q000097:blood
D012460:Sulfasalazine; D013427:Sulfapyridine