Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease.
We established that follicular dendritic cells (FDCs) are the site of abnormal prion protein (PrPCJD) accumulations in lymphoid tissues from mice infected with Creutzfeldt-Jakob disease. Evidence of positive FDC staining was observed in Creutzfeldt-Jakob disease-infected mice irrespective of the inoculation route, while no such staining was seen in the control mice. We also found that the severe combined immunodeficiency mouse trait is transmittable via the intracranial route but not via the intraperitoneal route. Mice with severe combined immunodeficiency did not have PrPCJD accumulation in FDCs.
Kitamoto
T
T
Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Muramoto
T
T
Mohri
S
S
Doh-Ura
K
K
Tateishi
J
J
D000818:Animals; D015153:Blotting, Western; D007562:Creutzfeldt-Jakob Syndrome / Q000382:microbiology* / Q000473:pathology; D005455:Fluorescent Antibody Technique; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D016513:Mice, SCID; D018620:PrPSc Proteins; D011328:Prions / Q000032:analysis / Q000235:genetics* / Q000302:isolation & purification; D013154:Spleen / Q000382:microbiology* / Q000473:pathology
D018620:PrPSc Proteins; D011328:Prions