The effects of intraocular pressure elevation on optic nerve axonal transport in the monkey.
Blockage of axonal transport by intraocular pressure (IOP) elevation was studied quantitatively in monkey eyes, using liquid scintillation counting. After 5 h of IOP elevation (perfusion pressure of 30 mmHg), axonally transported protein was measured in the distal third of each optic nerve, which was divided into superotemporal, inferotemporal, superonasal, and inferonasal portions. The ratio of the amount of radioactive protein in each portion of the optic nerve to that in the whole optic nerve was calculated. In eyes with IOP elevation, the mean ratio for the temporal optic nerve was significantly lower than that for the nasal optic nerve. It appeared that axonal transport was not affected homogenously throughout the optic nerve but was more impaired by the temporal half of the optic nerve following IOP elevation.
Department of Ophthalmology, Niigata University, School of Medicine, Japan.
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M
Shirakashi
D000704:Analysis of Variance; D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport; D005136:Eye Proteins / Q000378:metabolism; D007429:Intraocular Pressure; D008251:Macaca; D009898:Optic Disk / Q000473:pathology; D009900:Optic Nerve / Q000378:metabolism* / Q000473:pathology; D010477:Perfusion; D012588:Scintillation Counting
D005136:Eye Proteins