A role for CD8+ T lymphocytes in the pathogenesis of AIDS.
Experimental and clinical evidence is presented which supports the hypothesis that CD8+ T lymphocytes aimed at suppressing HIV replication in infected CD4+ T cells may have an important role in the pathogenesis of AIDS by directly causing a decrease in CD4+ T lymphocyte numbers. Possible models to test this hypothesis are discussed.
Aranda-Anzaldo
A
A
Laboratoire d'Immunobiologie, Faculté de Médecine, Paris V.
D000163:Acquired Immunodeficiency Syndrome / Q000473:pathology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D006678:HIV / Q000472:pathogenicity*; D006801:Humans; D007165:Immunosuppression Therapy; D008954:Models, Biological; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D016827:CD8 Antigens