Ultrastructural and immunohistochemical study of epithelioid hemangioendothelioma of bone: coexpression of epithelial and endothelial markers.
Four cases of epithelioid hemangioendothelioma of bone--a borderline malignant tumor of vascular origin--were studied ultrastructurally and immunohistochemically. The epithelioid tumor cells were positive for vimentin, polyclonal and monoclonal cytokeratins, and the endothelial markers factor VIII-related antigen (FVIII:RAg) and Ulex europaeus agglutinin I. The coexpression of polyclonal cytokeratin and FVIII:RAg was demonstrated by means of step sections in the same tumor cells. The endothelial origin of epithelioid tumor cells was supported ultrastructurally by identification of Weibel-Palade bodies.
Institute of Pathology, Medical Faculty, University of Nijmegen, The Netherlands.
U J
UJ
van Haelst
M
M
Pruszczynski
L N
LN
ten Cate
M
M
Mravunac
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001859:Bone Neoplasms / Q000032:analysis / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004727:Endothelium / Q000032:analysis; D004848:Epithelium / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D037102:Lectins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D037121:Plant Lectins; D012512:Sarcoma, Ewing / Q000648:ultrastructure*; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D014408:Biomarkers, Tumor; D037102:Lectins; D037121:Plant Lectins; C036850:Ulex europaeus lectins; D014746:Vimentin; D014841:von Willebrand Factor; D007633:Keratins