[Anomaly in the neurotransmitter amino acids in amyotrophic lateral sclerosis: a therapeutic application].
Although the cause of amyotrophic lateral sclerosis remains unknown, the excitatory amino acids may be involved in its pathogenesis. Glutamate level analysis shows a differential distribution of the amino acids. One of the therapeutic methods consists of reinforcing the inhibitory amino acid activity using L-threonine which has been shown to improve some symptoms and signs of ALS.
Clinique des Maladies du Système Nerveux et de l'Appareil Locomoteur, Marseille.
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O
Blin
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Desnuelle
C
C
Guelton
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G
Aubrespy
J P
JP
Ardissonne
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A
Crevat
J
J
Pouget
G
G
Serratrice
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000502:physiology; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D005971:Glutamates / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000502:physiology / Q000627:therapeutic use*; D013912:Threonine / Q000627:therapeutic use*
D000596:Amino Acids; D005971:Glutamates; D018377:Neurotransmitter Agents; D013912:Threonine
Anomalie des acides aminés neurotransmetteurs dans la sclérose latérale amyotrophique: une application thérapeutique.