[Comparative inhibitory analysis of DNA biosynthesis catalyzed by retrovirus reverse transcriptase].
Comparative study of DNA biosynthesis inhibition, catalyzed by avian myeloblastose virus (AMV) reverse transcriptase (RT), human immunodeficiency virus (HIV) recombinant and native RT, has been performed. 3'-Azido-2',3'-dideoxythymidine 5'-triphosphate (AzTTP); 3'-azido-2',3'-dideoxythymidine 5'-methylenephosphonate-diphosphate: 3'-azido-2',3'-dideoxythymidine 5'-phosphate-phosponoacetate; 3'-azido-2',3'-dideoxythymidine 5'-phosphate-dibromomethylenephosphonate; 2',3'-O-isopropylidenecytidine 5'-methylenephosphonate-diphosphate (rC-IP-MPDP) were used as inhibitors. AzTTP proved to by the most active inhibitor (its activity against HIV RT is higher than against AMV RT), although not selective as the phosphonates; only rC-iP-MPDP has low selectivity.
Kileso
T Iu
TIu
Tarusova
N B
NB
Atrazheva
E D
ED
Kukhanova
M K
MK
Shulenin
S V
SV
Bobkov
A F
AF
Garaev
M M
MM
Galegov
G A
GA
Kraevskiĭ
A A
AA
D009189:Avian Myeloblastosis Virus / Q000201:enzymology; D001358:Avian Sarcoma Viruses / Q000201:enzymology; D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000096:biosynthesis*; D006678:HIV / Q000201:enzymology; D009838:Oligodeoxyribonucleotides / Q000378:metabolism; D011061:Poly A; D012190:Retroviridae / Q000201:enzymology*; D018894:Reverse Transcriptase Inhibitors; D013698:Templates, Genetic; D015215:Zidovudine / Q000031:analogs & derivatives / Q000494:pharmacology
D009838:Oligodeoxyribonucleotides; D018894:Reverse Transcriptase Inhibitors; C027903:oligo (dT); D011061:Poly A; D015215:Zidovudine; D004247:DNA
Sravnitel'nyĭ ingibitornyĭ analiz biosinteza DNK, kataliziruemogo obratnymi transkriptazami retrovirusov.