[Infusion of high doses of platidiam in the treatment of patients with germ cell testicular tumors].
Sixteen patients with metastases of germ cell tumours were given VAB-6 combination chemotherapy including vinblastine, actinomycin-D, cyclophosphamide, bleomycin and platidiam (cis-platin). To intensify treatment 150 mg/m2 platidiam was administered by 24--hour infusion. Complete remission was observed in eight (50%) patients after chemotherapy alone; additional three (18.8%) cases were rendered tumor--free by surgery. At 20-26 months posttreatment, two cases were in relapse, and ten patients were alive. Toxicity was moderate. Infusion of high-dose platidiam assures a high complete remission rate, particularly, in cases of advanced germ cell tumours.
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D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002699:Chlorambucil / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004407:Dysgerminoma / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D013724:Teratoma / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy*; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D002699:Chlorambucil; D003609:Dactinomycin; D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin
Infuzii vysokikh doz platidiama pri lechenii bol'nykh s germinogennymi opukholiami iaichka.