The influence of agonists and antagonists of dopaminergic system on the formation of audiogenic seizures in rats during the ethanol abstinence period.
There have been numerous studies on the influence of ethanol on neurotransmitters, with conflicting results for the individual transmitters. It also refers to dopamine Hunt and Majchrowicz have found that dopamine circulation lowers after a prolonged administration of ethanol. The results of other experiments point out that such a long-lasting activity of ethanol has no influence on dopamine circulation. Tabakoff and Hoffman indicated that dopamine synthesis is lowered during the symptoms of ethanol abstinence. Griffiths et al. as well as Wajda et al. have proved that the level of dopamine in the striatum occurring at ethanol abstinence increases and comes back again to its initial value after 18 or 48 hrs. Fadda et al., while examining the prolonged influence of ethanol upon dopamine metabolism, has shown that after 24 hrs since the stop in ethanol administration, there has been an increase of dopamine level in the rat's frontal lobe of cortex cerebri. In other structures of the brain the dopamine level has not been changed. Darden and Hunt obtained the results showing a considerable decrease of dopamine liberation in the striatum during abstinence periods. In view of the biochemical research it is difficult to estimate explicitly the role of dopaminergic system in the appearance of dependence and symptoms of ethanol abstinence in the experimental animals. Some behavioral observations carried out on animals during the ethanol abstinence suggest that the prolonged administering of ethanol brings about hypofunction of central dopaminergic neurons.
Zakład Higieny, Akademia Medyczna w Lublinie.
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D000547:Amantadine / Q000494:pharmacology; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D018492:Dopamine Antagonists; D000431:Ethanol / Q000009:adverse effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control*; D013469:Sulpiride / Q000494:pharmacology
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D001971:Bromocriptine; D000431:Ethanol; D013469:Sulpiride; D000547:Amantadine; D006220:Haloperidol; D008787:Metoclopramide