Bidirectional regulation of cAMP generating system by dopamine-D1 and D2-receptors in the rat retina.
Accumulation or inhibition of cAMP formation in response to dopamine or dopamine related drugs in the absence or in the presence of forskolin and/or IBMX was investigated in isolated rat retina. While the existence of D1-receptors (positively coupled with adenylate cyclase) was confirmed, D2-receptors (negatively coupled to adenylate cyclase) were also revealed by using a selective D1-antagonist (SCH 23390), a D2-agonist (LY 171555) or two D2-antagonists (S-sulpiride, spiroperidol). These results indicate that rat retina may be used for the study of both types of dopamine-receptors.
Department of Biogenic Amines, Polish Academy of Sciences, Lodz.
J Z
JZ
Nowak
B
B
Sek
M
M
Schorderet
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004873:Ergolines / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012160:Retina / Q000187:drug effects / Q000378:metabolism*
D001552:Benzazepines; D004873:Ergolines; D011954:Receptors, Dopamine; D005576:Colforsin; D019257:Quinpirole; D000242:Cyclic AMP; D015056:1-Methyl-3-isobutylxanthine