Eccrine spiradenoma occurring in infancy mimicking mesenchymal tumor.
Eccrine spiradenoma (ES) rarely (less than 1%) occurs in infancy. These tumors differ from the conventional ES by the presence of superficial dermal nodules which display a less distinct two-cell pattern of immature adnexal epithelial cells and rarely ductule formation. These tumors may be mistaken for mesenchymal neoplasms involving the skin and subcutis of infants and young adults. Recognition of the histopathologic features and immunostains are required to make a definite diagnosis. We describe 2 cases of ES occurring in patients younger than one year. Detailed histopathologic and histochemical differential features of these tumors and mesenchymal neoplasms of the skin and subcutis commonly occurring in infants and young adults are discussed. The biologic behavior of infantile ES is benign, but complete excision is recommended to prevent recurrence. We speculate that these tumors may represent congenital hamartomatous growths.
Department of Dermatopathology, Armed Forces Institute of Pathology, Washington, D.C. 20306-6000.
G F
GF
Kao
W B
WB
Laskin
S W
SW
Weiss
D006607:Adenoma, Sweat Gland / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007633:Keratins / Q000378:metabolism; D008637:Mesenchymoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology
D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D007633:Keratins; D005293:Ferritins