Relationship between interdigestive duodenal motility and fluid transport in humans.
In 22 healthy volunteers distal duodenal fluid absorption was related to the interdigestive motility cycle. Fluid absorption was measured with a triple-lumen perfusion technique, and motility was registered with a low-compliance pneumohydraulic system. Pancreatic and biliary secretions were estimated by measurement of bilirubin and amylase release into the duodenal segment. Duodenal fluid absorption rate changed during the interdigestive motility cycle; the highest absorption rate was registered during phase I (low-motor activity) and absorption rate then decreased in parallel with increasing motor activity during phase II (r = -0.69, P less than 0.001). In late phase II a net fluid secretion was frequently registered, together with an increased release of bilirubin into the duodenal lumen. This pattern was seen during perfusion with both glucose-containing (30 mM) and glucose-free solutions. The results show that duodenal fluid absorption rate changes markedly during the interdigestive motility cycle. This effect may be a hydrodnamic phenomenon or may be due to activation of a neural secretory mechanism during phase II.
Department of Physiology, University of Göteborg, Sweden.
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Sjövall
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Hagman
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Abrahamsson
D000328:Adult; D000681:Amylases / Q000378:metabolism; D001663:Bilirubin / Q000032:analysis; D004386:Duodenum / Q000502:physiology*; D005260:Female; D005704:Gallbladder / Q000378:metabolism; D005769:Gastrointestinal Motility; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007441:Intubation, Gastrointestinal / Q000295:instrumentation / Q000379:methods; D008297:Male; D008353:Mannitol; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology; D010179:Pancreas / Q000201:enzymology; D011092:Polyethylene Glycols; D011312:Pressure
D008353:Mannitol; D011092:Polyethylene Glycols; D000681:Amylases; D005947:Glucose; D001663:Bilirubin