Parenteral nutrient admixtures as drug vehicles: theory and practice in the critical care setting.
Parenteral nutrient (PN) admixtures are the most complex, extemporaneously compounded formulations routinely prepared for hospitalized and home-based patients. In addition, drugs are added with increasing frequency to PN admixtures, thus presenting even greater physicochemical challenges to this highly complex pharmaceutical product. The continuous infusion of selected drugs may provide pharmacokinetic and therapeutic advantages over conventional, intermittent, bolus methods of administration. Fluid conservation, cost savings, and a possible decrease in the risk of infection through reduced catheter manipulation and simplification of therapy provide additional incentives to consider the use of PN admixtures. The many advantages of PN admixtures make them an attractive approach to cost-effective care, with special clinical benefits achieved in the critical care setting. This article reviews our clinical experience using PN admixtures as drug vehicles for selected drugs and presents some theoretical as well as actual benefits associated with this practice.
Driscoll
D F
DF
Pharmacy Department, New England Deaconess Hospital, Boston, MA 02215.
Baptista
R J
RJ
Mitrano
F P
FP
Mascioli
E A
EA
Blackburn
G L
GL
Bistrian
B R
BR
D000628:Aminophylline / Q000008:administration & dosage; D003422:Critical Care; D004355:Drug Stability; D006493:Heparin / Q000008:administration & dosage; D006635:Histamine H2 Antagonists / Q000008:administration & dosage; D006801:Humans; D007263:Infusions, Parenteral; D010288:Parenteral Nutrition; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles; D012307:Risk Factors; D012709:Serum Albumin / Q000008:administration & dosage
D006635:Histamine H2 Antagonists; D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles; D012709:Serum Albumin; D000628:Aminophylline; D006493:Heparin