MPTP lesions and dopaminergic drugs alter eye blink rate in African green monkeys.
Eye blink rates were studied in African green monkeys following relatively specific destruction of substantia nigra and its dopamine projections with the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Monkeys treated with MPTP had a significantly lower blink rate than controls over a period from two to five and a half months after treatment. Furthermore, the degree of parkinsonism expressed in treated animals was inversely correlated with blink rate. Pharmacologic studies further supported the role of dopamine receptors in the regulation of blink rate. PHNO (4-propyl-9-hydroxynaphoxazine), a potent and highly specific D2 agonist, effective in alleviating parkinsonism, caused a significant transient increase in blink rate, while sulpiride, a D2 antagonist, caused a decrease and blocked the effect of PHNO. Apomorphine and haloperidol, although less specific, had potent and predictable effects based on their interactions with dopamine systems. Blink rate may provide a nonintrusive measure of central dopamine activity that would help to evaluate the progress of Parkinson's disease or treatments which attempt to restore dopamine function.
Neurobehavior Laboratory, Yale University School of Medicine, New Haven, CT 06510.
M S
MS
Lawrence
D E
DE
Redmond
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001767:Blinking / Q000187:drug effects* / Q000502:physiology; D002522:Chlorocebus aethiops; D015259:Dopamine Agents / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D020267:MPTP Poisoning; D008297:Male; D010078:Oxazines / Q000494:pharmacology; D010300:Parkinson Disease / Q000209:etiology; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology; D013469:Sulpiride / Q000494:pharmacology
D015259:Dopamine Agents; D010078:Oxazines; D011954:Receptors, Dopamine; C042631:naxagolide; D013469:Sulpiride; D006220:Haloperidol; D001058:Apomorphine