Chromosome abnormalities in skin fibroblasts probably induced by an anti-cancer drug.
Chromosome findings in cultured skin fibroblasts from a patient treated with an anti-cancer drug, pepleomycin sulfate, for his penis cancer are reported. In two batches of specimens (days 16 and 34, respectively), out of 120 cells examined, a total of 26 abnormal cells (21.7%) were found with no common chromosome abnormalities; there were no clones. This cytogenetic pattern of abnormalities without clones in cultured skin fibroblasts differs from that seen in congenital disease or radiation-exposed skin fibroblasts. It is suggested that the anti-cancer agent is the most likely etiological factor for these uncloned chromosome abnormalities in cultured skin fibroblasts.
Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
N
N
Sadamori
T
T
Honda
F
F
Toriyama
D001761:Bleomycin / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000188:drug therapy; D017663:Peplomycin; D012867:Skin / Q000187:drug effects / Q000648:ultrastructure
D001761:Bleomycin; D017663:Peplomycin