Comparison of routes of administration and time course effects of zacopride and buspirone in mice using an automated light/dark test.
The behavioral effects of zacopride and buspirone were assessed in mice in a fully automated 2-compartment light/dark test. A significant increase in time mice spent in the lit area was used as an indication of anxiolytic-like action. Doses of zacopride from 0.0001 to 17.8 mg/kg, IP, and buspirone from 3.16 to 17.8 mg/kg, IP, produced significant increases in time mice spent in the lit area of the chamber. In addition, zacopride and buspirone were compared for oral potency and for duration of action after IP and PO administration. Zacopride and buspirone produced anxiolytic-like activity between doses of 0.001 to 100.0 mg/kg, PO, and 10.0 to 56.2 mg/kg, PO, respectively. The duration of effect of buspirone was 2 to 4 h after IP or PO administration, while that for zacopride was greater than or equal to 16 h by either route of administration. Thus, when compared for anxiolytic-like effects in this test, zacopride is a more potent and longer acting agent than buspirone.
Young
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Department of Pharmacology, A.H. Robins Co., Inc., Richmond, VA 23261-6609.
Johnson
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D000284:Administration, Oral; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage; D001007:Anxiety / Q000209:etiology*; D001549:Benzamides / Q000008:administration & dosage*; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002065:Buspirone / Q000008:administration & dosage*; D003624:Darkness; D005260:Female; D007274:Injections, Intraperitoneal; D008027:Light; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001549:Benzamides; D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; C055971:zacopride; D002065:Buspirone