Improvement in RBC flux, acidosis and oxygenation in tumour microregions by Fluosol-DA 20%.
Using laser Doppler flowmetry, we investigated the effects of Fluosol-DA 20% on RBC flux in FSaII tumours and on RBC flux in normal skin of C3H mice. The RBC flux in tumours was significantly increased; however, the RBC flux in normal skin fluctuated only slightly after the treatment with Fluosol-DA 20%. Since an increase in RBC flux by Fluosol-DA 20% may facilitate the removal of acidic metabolites from the tumours, the effects of Fluosol-DA 20% on intratumour pH was also measured. We also measured intratumour pO2 after various dosages of Fluosol-DA 20% with carbogen inhalation. We concluded that the administration of Fluosol-DA 20% selectively increased the RBC flux in tumours compared to that in normal skin. Moreover, carbogen inhalation combined with increasing dosages up to 36 ml/kg of Fluosol-DA 20% effectively enhanced tumour oxygenation in FSaII tumours.
Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota Medical School, Minneapolis 55455.
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Lee
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Cunningham
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Levitt
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D005354:Fibrosarcoma / Q000098:blood supply / Q000503:physiopathology*; D005466:Fluorocarbons / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D006895:Hydroxyethyl Starch Derivatives; D007834:Lasers; D051379:Mice; D008809:Mice, Inbred C3H; D010100:Oxygen / Q000378:metabolism*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D011838:Radiation-Sensitizing Agents; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen