[A hepatocellular carcinoma showing sarcomatous features and an extensive metastasis].
A 47-year-old female was admitted for a right hypochondrial pain and was diagnosed as having a hepatic tumor with a cystic lesion. After a right and a caudal lobectomy, she died of hepatic failure due to a tumoral recurrence. At autopsy, a cystic tumoral nodule, 15 x 7 cm in size, and numerous other nodules were revealed in the liver. Metastases were seen in both lungs, the left kidney, the colon, the mesenterium, the peritoneum, the diaphragm, and the para-pancreatic lymph nodes. The hepatic tumors consisted of four types of tumor cells: spindle, round, mixed (spindle and round cells), and cells with pseudoalveolar features. All tumor cells showed a positive immunohistochemical reaction to polyclonal keratin, low molecular monoclonal keratin, alpha 1 anti-trypsin, vimentin and to actin in their cytoplasms. This is considered a very rare case.
Dept. of Pathology, Nippon Med. School.
T
T
Ishiwata
N
N
Yamada
M
M
Yokoyama
G
G
Asano
D000199:Actins / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology*; D014746:Vimentin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000199:Actins; D014408:Biomarkers, Tumor; D014746:Vimentin; D000515:alpha 1-Antitrypsin; D007633:Keratins