The effects of a range of anti-cancer drugs in the white-ivory somatic mutation test in Drosophila.
The white-ivory test is based upon the reversion of the X-linked, recessive eye-colour mutation white-ivory to wild-type. Somatic reversion of white-ivory results in clones of red facets in the white-ivory eyes of eclosing adult flies. 4 anti-cancer drugs, bleomycin, adriamycin, mitoxantrone and cyclophosphamide were found to significantly increase the white-ivory reversion frequency whereas cytosine arabinoside, methotrexate and vincristine did not give positive results.
Department of Biology, University of York, Heslington, Great Britain.
J
J
Clements
D
D
Howe
A
A
Lowry
M
M
Phillips
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D004330:Drosophila / Q000187:drug effects* / Q000235:genetics; D005069:Evaluation Studies as Topic; D005260:Female; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods*; D010858:Pigmentation / Q000235:genetics
D000970:Antineoplastic Agents