Functional subsets of allergen-reactive human CD4+ T cells.
After a period of resistance, the concept of human helper T (TH)-cell subsets is gaining currency. This is the result of analyses from a number of laboratories on the cytokine profiles of T-cell clones prepared from chronically-infected and hypersensitive individuals. Here, Martien Kapsenberg and colleagues summarize these studies and speculate on the significance of skewed TH1 and TH2 responses.
Kapsenberg
M L
ML
Laboratory of Cell Biology and Histology, Academisch Medisch Centrum, Amsterdam, The Netherlands.
Wierenga
E A
EA
Bos
J D
JD
Jansen
H M
HM
D000485:Allergens / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007378:Interleukins / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000485:Allergens; D007378:Interleukins; D008222:Lymphokines