Decreased responsiveness of superficial hand veins to phenylephrine in black normotensive males.
Essential hypertension is more prevalent among blacks than whites although the explanation is unknown. It is possible that an altered vascular adrenoceptor responsiveness in blacks may play a role in the etiology of this racial difference. To test this hypothesis, we have compared the diameter changes in superficial veins in response to phenylephrine, an alpha-adrenergic agonist, and to isoproterenol, a beta-adrenergic agonist, in black and white young normotensive males using the dorsal hand vein compliance technique. The maximal venoconstriction after phenylephrine (Emax) was 92 +/- 9% (mean +/- SD) in the whites but only 74 +/- 12% in the blacks (p = 0.00046). The ED50 of phenylephrine was 342 ng/min (geometric mean) in whites and 245 ng/min in blacks (p = 0.50). The Emax and ED50 for isoproterenol-mediated venodilation was not significantly different between the racial groups. These results indicate a decreased maximal responsiveness to alpha-adrenergic stimulation in normotensive blacks. How these changes relate to cardiovascular alterations in hypertensive blacks requires further study.
Division of Clinical Pharmacology, Stanford University School of Medicine, California.
H G
HG
Eichler
T F
TF
Blaschke
B B
BB
Hoffman
D000293:Adolescent; D000328:Adult; D044383:Black People; D004305:Dose-Response Relationship, Drug; D006225:Hand / Q000098:blood supply*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology; D012039:Regional Blood Flow / Q000187:drug effects
D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D007545:Isoproterenol