A study of adult T-cell leukemia virus (ATLV) infection in the field of obstetrics: its epidemiology, vertical transmission and familial clustering.
Nine hundred and seventy-one healthy individuals in Iwate Prefecture, 659 pregnant women in Ishigaki Island, 487 pregnant women in Chiba Prefecture and 108 familial members of the ATLA-Ab-positive pregnant women (pregnant carrier women) were tested for ATLA-Ab by the PA, EIA and WB tests. 1) The rate of agreement of EIA with the PA test was 88.4% and there were no false negative sera by both examinations. These results indicate the both tests are available for mass screening. 2) In Iwate and Chiba Prefectures, the ATLA-Ab-positive rates of pregnant women were 5.3 and 0.6%, respectively. In addition, the incidences for healthy individuals ranged from 5.3 to 21.1% by age in Iwate Prefecture. Thus, Iwate Prefecture was found to equal Ishigaki Island (7.1%) in ATLA-Ab detection rates. 3) Forty-five (41.7%) out of 108 familial members of 15 pregnant carrier women were found to be seropositive for ATLA-Ab, which confirms a certain familial clustering of ATLV.
Department of Obstetrics and Gynecology, Chiba University School of Medicine, Japan.
R
R
Matsumoto
N
N
Inaba
H
H
Shimizu
H
H
Yamaguchi
S
S
Cho
H
H
Takamizawa
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000372:Agglutination Tests; D015153:Blotting, Western; D002353:Carrier State / Q000453:epidemiology*; D002648:Child; D003430:Cross-Sectional Studies; D015480:Deltaretrovirus Antibodies / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007564:Japan; D015458:Leukemia, T-Cell / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D015995:Prevalence; D012737:Sex Factors
D015480:Deltaretrovirus Antibodies