[An electron microscopic study of the structure of the rat liver under the action of antimembrane antibodies].
Introduction of heteroantibodies (4 mg/100 g) to plasma membranes of hepatocytes into portal vein of the rat liver caused (already within 5 min) changes in the liver ultrastructure with their intensification by the 30th min. Specificity of the action of antimembrane antibodies (Am) was revealed as against the action of antibodies to summary antigens (As) of the liver. It is shown that Am change, mainly, sinusoidal and lateral regions of the hepatocyte membrane, not disturbing essentially structure of its cytoplasma, intracellular organelles and biliary canaliculi, endotheliocytes and stellate reticuloendotheliocytes, that is observed while introducing As to the liver. Membrane tracer--colloidal lanthanum has revealed that Am increases permeability of hepatocyte plasmalemma to a less degree than As of the liver.
N V
NV
Makogon
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology*; D000918:Antibody Specificity / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology / Q000648:ultrastructure; D007114:Immunization; D008099:Liver / Q000276:immunology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005719:gamma-Globulins / Q000276:immunology
D000910:Antibodies, Heterophile; D005719:gamma-Globulins
Elektronno-mikroskopicheskoe izuchenie struktury pecheni krys pri deĭstvii antimembrannykh antitel.