Adoptive transfer of viable motheaten pathology in sublethally irradiated beige recipient mice.
B6 viable motheaten (mev) mice are short-living autoimmune and immunodeficient mice. Most of the mev pathology is transferable into the B6 beige (bg) irradiated mouse by injection of mev haematopoietic cells. Indeed there is a rapid establishment of lung damage, thymus aplasia, inflammation and necrosis of peripheral joints, an increase of serological IgM concentrations and autoantibody levels as well as a rapid death. This mev-type pathology can be again obtained by transferring haematopoietic cells of these [mev----bg] chimeras into other irradiated bg mice, although the appearance of these serological and phenotypical symptoms seems to be more and more delayed when doing cascade transfers.
Laboratoire d'Immunologie, Université Louis Pasteur, Strasbourg, France.
L
L
Kuntz
E
E
Montecino-Rodriguez
B
B
Jachez
D
D
Roman
F
F
Loor
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D016026:Bone Marrow Transplantation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007958:Leukocyte Count; D051379:Mice; D008815:Mice, Inbred Strains; D011828:Radiation Chimera / Q000276:immunology; D013154:Spleen / Q000637:transplantation
D007074:Immunoglobulin G; D007075:Immunoglobulin M