Species difference in the urinary excretion of isatinecic acid from the pyrrolizidine alkaloid retrorsine.
1. The urinary excretion of the metabolites, isatinecic acid and pyrrolic metabolites from the pyrrolizidine alkaloid retrosine were lower in the resistant species, guinea-pigs, than the susceptible species, mice, hamsters and rats. 2. The urinary N-oxides levels, however, were higher in guinea-pigs relative to mice, hamsters and rats. 3. These results conform to the postulate that a common metabolic pathway exists between the formation of isatinecic acid and pyrrolic metabolites. 4. The resistance of guinea-pigs to PA poisoning is attributed to the high metabolism of PAs to N-oxides combined with a corresponding low conversion to pyrrolic metabolites.
Department of Veterinary Pharmacology and Toxicology, University of California, Davis 95616.
P S
PS
Chu
H J
HJ
Segall
D000818:Animals; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D003998:Dicarboxylic Acids / Q000652:urine*; D006168:Guinea Pigs; D008297:Male; D008322:Mammals / Q000652:urine*; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D015394:Molecular Structure; D010087:Oxides / Q000652:urine; D011758:Pyrroles / Q000652:urine*; D011763:Pyrrolizidine Alkaloids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D003998:Dicarboxylic Acids; D010087:Oxides; D011758:Pyrroles; D011763:Pyrrolizidine Alkaloids; C074569:isatinecic acid; C003300:retrorsine