Effect of continuous LDL apheresis with dextran-sulfate cellulose column system on a child with homozygous familial hypercholesterolemia.
A new system for selective low density lipoprotein apheresis with an automated regenerating column using dextran-sulfate (DS) as ligand was evaluated for six months in a 13-year-old boy homozygous for familial hypercholesterolemia. Two columns each containing 150 ml of DS cellulose were alternately used after rinsing with a regenerating solution. The patient could well tolerate the volume in the system. The values of plasma total cholesterol decreased by 79.4 +/- 4.9% of the pretreatment levels after a total of 5l plasma apheresis, while those of high density lipoprotein cholesterol did not change. Although the values of CH50 decreased, no adverse reaction was seen during the period of treatment. It was concluded that the present apheresis system was highly efficacious and safe for children homozygous for the mutant LDL receptor gene.
Yoshimoto
M
M
Department of Pediatrics, Nagasaki University School of Medicine, Japan.
Tsuru
A
A
Sawai
T
T
Kinoshita
E
E
Baba
T
T
Yokoo
T
T
Yanagi
T
T
Tsuji
Y
Y
D000293:Adolescent; D008078:Cholesterol, LDL / Q000097:blood*; D016264:Dextran Sulfate; D003911:Dextrans; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000628:therapy*; D008297:Male; D010956:Plasmapheresis / Q000295:instrumentation / Q000379:methods*
D008078:Cholesterol, LDL; D003911:Dextrans; D016264:Dextran Sulfate