Prolongation of bupivacaine effect in epidural block by dextraven-150.
A double blind study was conducted on 84 subjects (needing surgery) of both sexes who were randomly divided into two groups. In group I 30 ml of 0.33 per cent bupivacaine (20 ml 0.5% bupivacaine + 10 ml of N saline) was injected epidurally and in group II 20 ml of 0.5 per cent bupivacaine + 10 ml of dextraven - 150 (6% solution in 5% dextrose). The subject were observed for the onset of block, degree of motor blockade, period of analgesia and complications during and after surgery. Dextran - 150 mixture significantly prolonged the duration of action of bupivacaine (13.5 +/- 6.25 h) when given epidurally, without affecting the onset, muscular paralysis, quality of block and the incidence of complications.
Tripathi
M
M
Department of Anaesthesiology, G.S.V.M. Medical College, Kanpur.
Krishna
O
O
D000328:Adult; D000767:Anesthesia, Epidural / Q000379:methods*; D002045:Bupivacaine / Q000494:pharmacology*; D003911:Dextrans / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007268:Injections, Epidural; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors
D003911:Dextrans; D002045:Bupivacaine