[A study on enoxacin concentration in human prostatic tissue].
To examine the penetration of enoxacin into prostatic tissue of patients with benign prostatic hypertropHy, the serum concentration and prostatic tissue level of enoxacin were measured. Enoxacin was administered orally at a dose of 200 mg, three times 2 days and one day before and once on the day of the operation. Blood and prostatic tissue samples were taken during the operation. The mean concentration of enoxacin was 2.84 +/- 0.349 g/ml in serum and 4.60 +/- 0.631 micrograms/ml in the prostatic tissue.
Department of Urology, Konodai Hospital National Center of Neurology and Psychiatry.
Y
Y
Kitamura
Z
Z
Kataumi
T
T
Nakamura
H
H
Takeda
D000368:Aged; D000369:Aged, 80 and over; D015365:Enoxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000601:surgery
D015365:Enoxacin