[The pharmacokinetics of dihydrostreptomycin sulfate in domestic pigeons (Columba livia Gmel., 1789 var. domestica)].
A 20% aqueous solution of dihydrostreptomycin sulfate in a dosage of 100 mg/kg b.w. is non-toxic for pigeons, although renal accumulation occurs. 12 hours after a single subcutaneous injection of 100 mg/kg b.w. the plasma concentration decreases to 3.64 micrograms/ml and therefore below the therapeutically effective concentration, while in birds suffering from salmonella infections plasma levels decrease to comparative concentrations (3.84 micrograms/ml) after only 8 hours. Contrary to the directions for use in pigeons of the preparation CX 60, the subsequent dosage should be given no later than 10 hours after the first application.
Institut für Geflügelkrankheiten, Ludwig-Maximilians-Universität München.
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D000818:Animals; D001715:Bird Diseases / Q000378:metabolism*; D010856:Columbidae / Q000378:metabolism*; D004096:Dihydrostreptomycin Sulfate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D007279:Injections, Subcutaneous / Q000662:veterinary; D007668:Kidney / Q000378:metabolism; D012481:Salmonella Infections, Animal / Q000378:metabolism*
D004096:Dihydrostreptomycin Sulfate
Zur Pharmakokinetik von Dihydrostreptomycinsulfat bei Haustauben (Columba livia Gmel., 1789 var. domestica).