Tilt aftereffect reveals early visual processing deficits in Parkinson's disease and in chronic schizophrenic patients on depot neuroleptic.
Previous studies suggest that the tilt aftereffect (TAE) may be used to indicate the site of dopaminergic abnormalities in the human visual system. In this study we investigated the TAE in patients with Parkinson's disease, and in chronic schizophrenic patients receiving depot injections of neuroleptic. The results suggest that the retina may be abnormal in both groups of patients, and that schizophrenic patients may also have cortical changes. The results are discussed in terms of the clinical implications of these visual changes.
Department of Psychology, University of Bristol, UK.
J E
JE
Calvert
J P
JP
Harris
O T
OT
Phillipson
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001931:Brain Mapping; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D005260:Female; D005366:Figural Aftereffect / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009949:Orientation / Q000187:drug effects / Q000502:physiology*; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D010364:Pattern Recognition, Visual / Q000187:drug effects / Q000502:physiology; D010468:Perceptual Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D012160:Retina / Q000187:drug effects / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014796:Visual Perception / Q000187:drug effects / Q000502:physiology*
D014150:Antipsychotic Agents; D003692:Delayed-Action Preparations; D011954:Receptors, Dopamine