Thermospray liquid chromatography/mass spectrometry of polar beta-blocking drugs: preliminary results.
The use of thermospray liquid chromatography for the screening of polar beta-blocking drugs is evaluated. The influence of instrumental parameters on the fragmentation pattern of labetalol, acebutolol, diacetolol, sotalol and atenolol is described. A short biomedical application is presented.
Netherlands Institute for Drugs and Doping Research, State University of Utrecht.
M S
MS
Leloux
W M
WM
Niessen
R A
RA
van der Hoeven
D000070:Acebutolol / Q000652:urine; D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D001262:Atenolol / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D066298:In Vitro Techniques; D007741:Labetalol / Q000652:urine; D013015:Sotalol / Q000652:urine
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D000070:Acebutolol; D013015:Sotalol; D007741:Labetalol