Reconstituted Newcastle disease virus envelopes as a split vaccine.
Isolated envelope proteins of Newcastle disease virus (NDV) were inserted into the lipid bilayer of artificial vesicles to create a viral envelope-like structure. The structure-containing viral antigens at high density elicited a strong immune response, in contrast to purified viral proteins. The artificial envelopes or immunosomes possessed several advantageous properties when used as vaccines. They elicited a faster response and the immunity lasted longer in animals treated with these vesicles than in controls vaccinated with envelope proteins in combination with traditional adjuvants. A further useful feature of the artificial envelopes is that no inflammatory lesions develop at the site of their injection.
Tóth
K
K
Phylaxia, Budapest, Institute of Biochemistry, Hungary.
Duda
E
E
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D002645:Chickens; D008081:Liposomes / Q000276:immunology; D008297:Male; D008823:Micelles; D009522:Newcastle disease virus / Q000276:immunology* / Q000648:ultrastructure; D014614:Vaccines, Synthetic / Q000737:chemistry*; D014759:Viral Envelope Proteins / Q000276:immunology* / Q000648:ultrastructure; D014765:Viral Vaccines / Q000138:chemical synthesis*
D000914:Antibodies, Viral; D008081:Liposomes; D008823:Micelles; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014765:Viral Vaccines