The prooxidant-induced and spontaneous mitochondrial calcium release: inhibition by meta-iodo-benzylguanidine (MIBG), a substrate for mono (ADP-ribosylation).
The norepinephrine analogue meta-iodo-benzylguanidine (MIBG), a substrate for mono(ADP-ribosylation) and inhibitor of eukaryotic ADP-ribosyltransferases, inhibits the prooxidant-induced and spontaneous calcium release from intact rat liver mitochondria without affecting pyridine nucleotide oxidation and hydrolysis. This finding strongly suggests regulation of calcium release by ADP-ribosylation in mitochondria, and may be relevant for the cellular and pharmacological effects of MIBG.
Laboratorium für Biochemie I, ETH, Zürich, Switzerland.
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D019797:3-Iodobenzylguanidine; D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D004533:Egtazic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D007462:Iodobenzenes / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012430:Ruthenium Red / Q000494:pharmacology; D014812:Vitamin K / Q000494:pharmacology
D002132:Calcium Radioisotopes; D007462:Iodobenzenes; D012430:Ruthenium Red; D014812:Vitamin K; D000246:Adenosine Diphosphate Ribose; D019797:3-Iodobenzylguanidine; D004533:Egtazic Acid; D002118:Calcium