Hb F-Jiangsu, the first gamma chain variant with a valine----methionine substitution: alpha 2A gamma 2 134(H12)Val----Met.
During a survey of cord blood samples of healthy Chinese babies an A gamma variant was detected by its partial separation from normal A gamma in a high performance liquid chromatographic experiment. Structural analysis of the isolated A gamma X chain identified a Val----Met substitution at position A gamma 134; this substitution created a rather unique Met-Met sequence. The ratio of A gamma X to A gamma was about 2 to 3; thus, Hb F with this variant A gamma chain appears to have approximately normal stability.
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
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D
Plaseska
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Kutlar
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JB
Wilson
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BB
Webber
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YT
Zeng
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Huisman
D000595:Amino Acid Sequence; D005312:Fetal Blood / Q000737:chemistry; D005319:Fetal Hemoglobin / Q000737:chemistry* / Q000235:genetics; D005914:Globins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008715:Methionine / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D014633:Valine / Q000235:genetics
D006455:Hemoglobins, Abnormal; C066867:hemoglobin F Jiangsu; D005914:Globins; D005319:Fetal Hemoglobin; D008715:Methionine; D014633:Valine