Demonstration of a range of inflammatory mediators released in trichostrongylosis of sheep.
The levels of inflammatory mediators in the intestinal contents of sheep immunized with Trichostrongylus colubriformis larvae increased in the first 6 days after challenge. These mediators were histamine, leukotriene C4, 6-keto-prostaglandin F1 alpha (from prostacyclin) and thromboxane B2. Leukotriene C4 was released in the greatest quantities. Leukotriene B4 was present but its concentration remained unchanged after challenge. The presence of these particular mediators in the intestinal contents after challenge is consistent with antigen-induced mediator release from the mucosal mast cells found in immune sheep undergoing challenge infection. This is the first sequential analysis of mediator release in sheep that also demonstrates the release of prostacyclin and thromboxane into the intestine during expulsion of a nematode infection.
CSIRO Division of Animal Health, McMaster Laboratory, New South Wales, Australia.
W O
WO
Jones
D L
DL
Emery
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D012898:Autacoids / Q000096:biosynthesis*; D006632:Histamine / Q000096:biosynthesis; D013189:SRS-A / Q000096:biosynthesis; D012756:Sheep; D012757:Sheep Diseases / Q000378:metabolism*; D013929:Thromboxane B2 / Q000096:biosynthesis; D014253:Trichostrongylosis / Q000378:metabolism / Q000662:veterinary*
D012898:Autacoids; D013189:SRS-A; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D006632:Histamine