Erythrocyte Li-Na countertransport in hypertension: lack of atrial natriuretic peptide effect.
The rate of erythrocyte Li-Na countertransport and cellular Na+ and K+ contents have been determined in normotensive (NT) and hypertensive (HT, essential hypertension) subjects in the presence and absence of atrial natriuretic peptide (ANP). The rate of Li-Na countertransport was significantly higher in erythrocytes of HT subjects, while the Na+ and K+ contents were not different between the NT and HT groups. We found that ANP (10(-9) and 10(-7) M) had no effect on either the rate of Li-Na countertransport or the cellular Na+ and K+ contents. Since ANP does not influence erythrocyte Na pump and Na-K-Cl cotransport, our results suggest that the Na transport systems of human erythrocytes do not respond to ANP and this lack of response in Li-Na countertransport is independent of the status of hypertension. These findings are consistent with the view that the rate of Li-Na countertransport of erythrocytes may serve as a useful genetic marker for essential hypertension in Chinese. However, the erythrocyte transport systems cannot provide further differentiation utilizing ANP response for essential hypertension.
Department of Physiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan, R.O.C.
Y T
YT
Lau
M S
MS
Chern
J S
JS
Hung
H C
HC
Liang
J F
JF
Kao
D000328:Adult; D017920:Antiporters; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000378:metabolism*; D002681:China / Q000208:ethnology; D004912:Erythrocytes / Q000737:chemistry* / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000378:metabolism*; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism
D017920:Antiporters; D015415:Biomarkers; D002352:Carrier Proteins; C045885:sodium-lithium countertransporter; D009320:Atrial Natriuretic Factor; D011188:Potassium