Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertension.
Insulin has cardiovascular actions and patients with essential hypertension display insulin resistance. A cross-sectional study of the R1 RFLP of the insulin receptor gene (INSR) was carried out in 67 hypertensive (HT) and 75 normotensive (NT) subjects whose parents had a similar blood pressure status at age greater than or equal to 50. The frequency of the minor (+) allele was 0.31 in HTs and 0.44 in NTs, and the difference between observed alleles in all subjects in each group was significant (chi 2 = 4.8, P less than 0.05). Allele frequencies of a BglI RFLP of the insulin gene, however, did not differ between the HT and NT groups. The data thus provide evidence in favour of an association of HT with a polymorphism at the INSR locus (19p13.3-13.2), so implicating this locus, and possibly a genetic variant of the insulin receptor itself, in HT.
Department of Physiology, University of Sydney, N.S.W., Australia.
L H
LH
Ying
R Y
RY
Zee
L R
LR
Griffiths
B J
BJ
Morris
D000328:Adult; D000368:Aged; D000483:Alleles; D001794:Blood Pressure; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D015342:DNA Probes; D015252:Deoxyribonucleases, Type II Site-Specific; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007328:Insulin / Q000235:genetics*; D007962:Leukocytes / Q000502:physiology; D012150:Polymorphism, Restriction Fragment Length; D011972:Receptor, Insulin / Q000235:genetics*; D012016:Reference Values
D015342:DNA Probes; D007328:Insulin; D004247:DNA; D011972:Receptor, Insulin; D015252:Deoxyribonucleases, Type II Site-Specific; C018492:GCCNNNNNGGC-specific type II deoxyribonucleases