Indirect role of T cells in development of polioencephalitis and encephalomyelitis induced by encephalomyocarditis virus.
Infection of female BALB/c mice with encephalomyocarditis virus results in the development of a paralytic syndrome in 7 to 10 days postinoculation. Previous studies had suggested the involvement of an immune component in the development of central nervous system pathology. We have examined the effects of T-cell depletion on the development of polioencephalitis (neuronal necrosis and inflammation of the brain and brain stem) and the relative contribution of the CD4+ and CD8+ subsets following the establishment of viremia. We show that monoclonal antibody depletion of T cells is effective in the reduction of polioencephalitis when given prior to viral inoculation. However, administration of the antibodies 12 h or more after viral inoculation failed to alter the development of polioencephalitis or encephalomyelitis. We conclude that T cells are involved in the development of central nervous system disease during the initial stages of infection but are not responsible for the later progression of disease.
Topham
D J
DJ
Department of Pathology, College of Medicine, University of Vermont, Burlington 05405.
Adesina
A
A
Shenoy
M
M
Craighead
J E
JE
Sriram
S
S
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004679:Encephalomyelitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D004686:Encephalomyocarditis virus / Q000502:physiology*; D005260:Female; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D011051:Poliomyelitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014766:Viremia / Q000150:complications / Q000473:pathology
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral