Fibroblast growth factor induces beta-amyloid precursor mRNA in glial but not neuronal cultured cells.
Treatment of PC12 and C6 cell cultures with recombinant basic fibroblast growth factor results in approximately a five to ten-fold stimulation of beta-amyloid precursor mRNA in the C6 astrocytoma cell line but only a slight induction of precursor mRNA in the PC-12 neuronal cell line. Stimulation of expression occurred at a hormone concentration of approximately 0.5 to 1 nM and was seen after 2 days. These results suggest that basic fibroblast growth factor may contribute to amyloidosis of Alzheimer's disease.
California Biotechnology, Inc., Mountain View 94043.
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D000544:Alzheimer Disease / Q000235:genetics*; D000682:Amyloid / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002478:Cells, Cultured; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000494:pharmacology; D009417:Nerve Tissue / Q000473:pathology; D009457:Neuroglia / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D009693:Nucleic Acid Hybridization; D011498:Protein Precursors / Q000235:genetics*; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012322:RNA Precursors / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats
D000682:Amyloid; D016564:Amyloid beta-Protein Precursor; D009414:Nerve Growth Factors; D011498:Protein Precursors; D012322:RNA Precursors; D012333:RNA, Messenger; D005346:Fibroblast Growth Factors; D012313:RNA