HLA-DQA1*0101 haplotypes and disease outcome in early onset pauciarticular juvenile rheumatoid arthritis.
To further investigate a clinical impression that patients with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) who carry HLA-DQw1 have more severe arthritis, we subtyped HLA-DQw1 in American midwestern patients with EOPA-JRA. The HLA-DQA1*0101 subtype was present in 10 of 19 patients who developed persistent polyarticular erosive disease compared with 18 of 92 healthy controls (chi 2 = 9.13, p = 0.003, RR = 4.6), and occurred more frequently in this polyarticular group than in patients without polyarticular erosive disease (chi 2 = 4.11, p = 0.040, RR = 3.0). The presence of HLA-DQA1*0101 was significantly lower in patients with chronic iridocyclitis than in patients without chronic iridocyclitis (chi 2 = 7.07, p = 0.008, RR = 0.21). In HLA-DQA1*0101 positive patients, DNA sequences of the beta-1 domain of the HLA-DQ alpha and HLA-DQ beta genes (HLA-DQA1*0101, HLA-DQB1*0501 and HLA-DQB1*0503) were identical to those in controls. In this midwestern EOPA-JRA population, HLA-DQA1*0101 or genes in linkage disequilibrium with it, are associated with a cohort of patients with EOPA-JRA with distinct clinical characteristics.
Division of Pediatric Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229-2899.
C
C
van Kerckhove
L
L
Luyrink
J
J
Taylor
H
H
Melin-Aldana
K
K
Balakrishnan
W
W
Maksymowych
M
M
Elma
D
D
Lovell
E
E
Choi
D N
DN
Glass
D000483:Alleles; D000595:Amino Acid Sequence; D001171:Arthritis, Juvenile / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology*; D059848:HLA-DQ alpha-Chains; D006239:Haplotypes / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C051568:HLA-DQ1 antigen; C069050:HLA-DQA1 antigen; D004247:DNA