The negative inotropic effect of diazepam in rat right ventricular strips.
The effect of diazepam on cardiac contractility was investigated in electrically-driven right ventricular strips of the rat. Diazepam produced a concentration-dependent negative inotropic effect which was antagonized by either flumazenil, a benzodiazepine central-type receptor antagonist, or PK 11195, a benzodiazepine peripheral type receptor antagonist. The results suggest that the inhibitory effect of diazepam on cardiac contractility in the rat is mediated by both central and peripheral benzodiazepine receptors.
Departamento de Fisiología y Farmacología, Facultad de Medicina, Espinardo-Murcia, Spain.
J
J
Hernández
D000818:Animals; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D005442:Flumazenil / Q000494:pharmacology; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects
D007546:Isoquinolines; D011963:Receptors, GABA-A; D005442:Flumazenil; D003975:Diazepam; C037850:PK 11195