Is the predisposition to neuroleptic malignant syndrome genetically transmitted?
A Japanese family consisting of a mother and her two daughters, all experienced NMS on therapeutic or subtherapeutic doses of neuroleptics. The mother and the elder daughter had past histories of severe neuroleptic-induced extrapyramidal symptoms. The predisposition to this syndrome may be genetically transmitted. We suggest that neuroleptic treatment should be introduced with extreme caution to a patient with a family history of NMS.
Department of Neuropsychiatry, Hirosaki University Hospital, Japan.
K
K
Otani
M
M
Horiuchi
T
T
Kondo
S
S
Kaneko
Y
Y
Fukushima
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis / Q000235:genetics*; D009460:Neurologic Examination; D012008:Recurrence; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D012560:Schizophrenia, Catatonic / Q000188:drug therapy / Q000235:genetics / Q000523:psychology; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents