Expression of transforming growth factor-beta 1 mRNA in human hepatocellular carcinoma.
We investigated the expression of transforming growth factor beta 1 (TGF-beta 1) mRNA in tumor tissues surgically removed from ten patients with hepatocellular carcinoma (HCC). All HCC tissues expressed TGF-beta 1 mRNA at different levels, indicating the presence of activated transcription of TGF-beta 1 gene in human HCC tissues in vivo. The level of TGF-beta 1 mRNA expression showed no relationship to main tumor size of plasma alpha-fetoprotein level. Some HCC tissues presenting a relatively low grade of histological differentiation showed the highest levels of TGF-beta 1 mRNA expression.
Second Department of Internal Medicine, Osaka University Medical School.
N
N
Ito
S
S
Kawata
S
S
Tamura
K
K
Takaishi
I
I
Yabuuchi
Y
Y
Matsuda
M
M
Nishioka
S
S
Tarui
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis*; D016212:Transforming Growth Factor beta / Q000235:genetics*; D000509:alpha-Fetoproteins / Q000032:analysis
D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D000509:alpha-Fetoproteins