Effect of the thiol group on experimental gold-induced autoimmunity.
Brown Norway rats injected with aurothiopropanolsulfonate sodium salt develop systemic autoimmunity. The aim of this study was to assess the influence of the sulfur-containing group in this experimental model of gold-induced autoimmunity. It was shown that the sulfur-containing group does not induce autoimmunity of itself, but potentiates the immunotoxic effects of gold.
Tournade
H
H
INSERM U28, Department de Pathologie Rénale et Vasculaire, Hôpital Broussais, Paris, France.
Guery
J C
JC
Pasquier
R
R
Vial
M C
MC
Mandet
C
C
Druet
E
E
Dansette
P M
PM
Druet
P
P
Pelletier
L
L
D000818:Animals; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000188:drug therapy; D015551:Autoimmunity / Q000187:drug effects*; D004112:Dimercaprol / Q000009:adverse effects / Q000031:analogs & derivatives*; D004195:Disease Models, Animal; D005260:Female; D050607:Organogold Compounds; D009942:Organometallic Compounds / Q000009:adverse effects*; D020005:Propanols; D051381:Rats; D011914:Rats, Inbred BN; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*
D018501:Antirheumatic Agents; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; C013394:aurotioprol