Chronic mucocutaneous candidiasis with deficient CD2 (E receptor) but normal CD3 mononuclear cells.
A case of chronic mucocutaneous candidiasis in a Malaysian child who subsequently developed disseminated tuberculosis and toxoplasmosis is described. The phenotype of her peripheral blood mononuclear cells showed discordance for her T cell markers. The presence of a subpopulation of CD2-/CD3+ mononuclear cells leading to an immunodeficiency state is consistent with failure of activation of CD2-mediated alternative pathway resulting in immunodeficiency. Such abnormal CD2-/CD3+ subpopulations have been described in lepromatous leprosy and foetal abortuses.
Department of Paediatrics, General Hospital Kuala Lumpur, Malaysia.
L M
LM
Noh
S H
SH
Hussein
K D
KD
Sukumaran
I
I
Rose
N
N
Abdullah
D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics; D018801:CD2 Antigens; D017252:CD3 Complex / Q000032:analysis*; D002178:Candidiasis, Chronic Mucocutaneous / Q000150:complications* / Q000276:immunology; D002180:Candidiasis, Oral / Q000150:complications* / Q000276:immunology; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000235:genetics / Q000276:immunology; D007223:Infant; D008213:Lymphocyte Activation; D009894:Opportunistic Infections / Q000150:complications* / Q000276:immunology; D011971:Receptors, Immunologic / Q000235:genetics; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014123:Toxoplasmosis / Q000150:complications / Q000276:immunology; D014376:Tuberculosis / Q000150:complications / Q000276:immunology
D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D017252:CD3 Complex; D011971:Receptors, Immunologic