Presentation of endogenous immunoglobulin determinant to immunoglobulin-recognizing T cell clones by the thymic cells.
Using immunoglobulin (Ig)-recognizing T helper clones the expression of Ig peptide/major histocompatibility complex class II complexes derived by the processing of endogeneous Ig molecules in the thymus was demonstrated. It was found that thymic B cells but not "classic" thymic antigen-presenting cells and macrophages represent the major antigen-presenting cell type of determinants of endogenously synthesized surface Ig (Ig kappa-1b) and anti-surface Ig antibodies (IdC3B9). The Ig kappa-1b-presenting activity in the thymus appears relatively late, only after 3 weeks of postnatal life, while in the spleen an efficient presentation of endogenous Ig kappa-1b epitope is observed very early after birth. This difference between thymic and peripheral presentation of endogeneous Ig determinant could be important for understanding the mechanisms of T cell tolerance to self Ig and the role of self Ig in negative and positive selection of T cell repertoire.
Laboratory of Immunology, All-Union Research Institute for Genetics, Moscow.
A Y
AY
Rudensky
S M
SM
Mazel
V L
VL
Yurin
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000502:physiology*; D001324:Autoantigens / Q000276:immunology*; D002999:Clone Cells; D000939:Epitopes / Q000276:immunology*; D005260:Female; D007126:Immunoglobulin Allotypes / Q000276:immunology; D007074:Immunoglobulin G / Q000096:biosynthesis; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology*; D008213:Lymphocyte Activation; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology / Q000502:physiology*
D001324:Autoantigens; D000939:Epitopes; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007136:Immunoglobulins