Effects of d-amphetamine injected into the nucleus accumbens on ethanol reinforced behavior.
Rats, initiated to self-administer 10% (v/v) ethanol in an operant situation using the sucrose-fading procedure, received bilateral n. accumbens microinjections of d-amphetamine prior to operant sessions. Doses of 4 micrograms, 10 micrograms and 20 micrograms/brain were administered and some animals also received a 4 microgram/brain dose of LY171555. Three different effects were observed: increased, decreased and no change in total session responding. There was no clear relation between injection area in the n. accumbens and type of effect observed. For either an increase or decrease in total session responding, momentary response rates were decreased. Both d-amphetamine and LY171555 produced similar results. The data support the hypothesis that dopamine in the n. accumbens is involved with ethanol reinforced operant responding but in a complex manner.
Alcohol and Drug Abuse Institute, University of Washington, Seattle 98105.
H H
HH
Samson
G A
GA
Tolliver
M
M
Haraguchi
P W
PW
Kalivas
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D015259:Dopamine Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009714:Nucleus Accumbens / Q000502:physiology*; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D012054:Reinforcement, Psychology
D015259:Dopamine Agents; D004873:Ergolines; D019257:Quinpirole; D000431:Ethanol; D000661:Amphetamine