[Synthesis and evaluation of central nervous system activity of new triaza-spirodecanediones].
It has been possible to prepare from 8-(2-phenylethyl)-1,3,8-triaza [4, 5] spirodecane-2,4-dione a new series of derivatives substituted on the nitrogen atom in the 3-position of the hydantoïn ring. Several compounds exhibited sedative, anticonvulsant and anxiolytic activities. The aryl or heteroaryl-piperazinomethyl substituted compounds were the most active derivatives. "Buspirone-like" anxiolytic effects were found in some compounds from 5 mg/kg dose per os.
Coudert
P
P
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Clermont-Ferrand.
Rubat
C
C
Couquelet
J M
JM
Bastide
J
J
Bastide
P
P
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D002491:Central Nervous System Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D051379:Mice
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D002491:Central Nervous System Agents; D006993:Hypnotics and Sedatives
Synthèse et évaluation de l'activité sur le système nerveux central de nouvelles triaza-spirodécanediones.