Squamous cell carcinoma of the esophagus with cartilaginous metaplasia at metastatic lesions.
Subdermal metastatic nodules in a 62-year old male patient with esophageal carcinoma contained both carcinomatous and chondroid areas. The carcinomatous areas showed the histology of poorly differentiated squamous cell carcinoma, and light microscopically an apparent transition could be traced from carcinomatous cells to chondroid cells. In the chondroid cells, the characteristics of chondrocytes were demonstrated by light microscopic, electron microscopic, histochemical and immunohistochemical studies, although nuclear atypism was evident, suggesting their malignancy. Furthermore, immunohistochemical studies showed that some chondroid cells contained both keratin proteins and squamous cell carcinoma antigen, which were also found in the carcinomatous cells. These findings together with the light microscopic observations suggest that chondroid cells are derived from squamous cell carcinoma cells.
Terada
N
N
Department of Pathology, Center for Adult Diseases, Osaka, Japan.
Yamamoto
R
R
Ishiguro
S
S
Hata
K
K
Sawada
M
M
Hiramatsu
Y
Y
Hioki
K
K
Kitamura
Y
Y
D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary; D002356:Cartilage / Q000166:cytology / Q000473:pathology*; D003094:Collagen; D004938:Esophageal Neoplasms / Q000473:pathology*; D005109:Extracellular Matrix / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008297:Male; D008679:Metaplasia; D008854:Microscopy, Electron; D008875:Middle Aged
D007633:Keratins; D003094:Collagen