Intravenous immune globulin for the treatment of presumed quinidine-induced thrombocytopenia.
Quinidine is cited as one of the most frequent causes of drug-induced thrombocytopenia. This case report describes the use of high-dose intravenous gamma globulin to rapidly reverse quinidine-induced thrombocytopenia in a patient at increased risk for bleeding because of the presence of an antitachycardia pacemaker and an automatic implantable cardiac defibrillator. This report suggests that this treatment may aid in a more rapid reversal of quinidine-induced thrombocytopenia in patients at high risk of bleeding.
Department of Pharmacy, Hamot Medical Center, Erie, PA 16550.
J B
JB
Ray
W F
WF
Brereton
F R
FR
Nullet
D000328:Adult; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D010976:Platelet Count; D011802:Quinidine / Q000009:adverse effects*; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced / Q000628:therapy*; D005719:gamma-Globulins / Q000627:therapeutic use
D007136:Immunoglobulins; D005719:gamma-Globulins; D011802:Quinidine