Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region.
Hybridization studies using a panel of somatic cell hybrids with subchromosomal segments of 19q have localized the genes encoding hormone-sensitive lipase (LIPE), carcinoembryonic antigen (CEA), and small nuclear ribonucleoprotein polypeptide A (SNRPA) to various regions of 19q13.1; the cellular receptor for poliovirus sensitivity (PVS) to 19q13.2; and the genes coding for prostate-specific antigen (APS), human pancreatic kallikrein (KLK1), and small nuclear ribonucleoprotein 70-kD polypeptide (SNRP70) to 19q13.3----qter. Our results exclude several of these genes from being seriously considered as a candidate for the myotonic dystrophy gene on 19q.
Department of Human Genetics, University of Nijmegen, The Netherlands.
D
D
Schonk
P
P
van Dijk
P
P
Riegmann
J
J
Trapman
C
C
Holm
T C
TC
Willcocks
P
P
Sillekens
W
W
van Venrooij
E
E
Wimmer
A
A
Geurts van Kessel
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics; D015139:Blotting, Southern; D002272:Carcinoembryonic Antigen / Q000235:genetics; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D005796:Genes; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D007610:Kallikreins / Q000235:genetics; D008049:Lipase / Q000235:genetics; D008297:Male; D051379:Mice; D009223:Myotonic Dystrophy / Q000235:genetics*; D017955:Poliovirus; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000235:genetics; D011991:Receptors, Virus / Q000235:genetics; D012261:Ribonucleoproteins / Q000235:genetics; D017411:Ribonucleoproteins, Small Nuclear
D000951:Antigens, Neoplasm; D002272:Carcinoembryonic Antigen; D005819:Genetic Markers; D011991:Receptors, Virus; D012261:Ribonucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D008049:Lipase; D007610:Kallikreins; D017430:Prostate-Specific Antigen