Efficacy of mupirocin nasal ointment in eradicating Staphylococcus aureus nasal carriage in chronic haemodialysis patients.
Topical 2% mupirocin ointment eradicated chronic Staphylococcus aureus nasal carriage immediately post-therapy in 17 (77%) of 22 haemodialysis patients. Mean time to recurrence was 3.8 weeks. Similar pre-therapy and post-therapy phage types occurred in 12 (71%) of 17 patients. Staphylococcus aureus infections developed in none of 17 successfully treated patients, two of five treatment failures (P = 0.05), and 10 of 46 untreated patients studied concurrently (P = 0.03).
Holton
D L
DL
Section of Infectious Diseases, University of Manitoba.
Nicolle
L E
LE
Diley
D
D
Bernstein
K
K
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002353:Carrier State / Q000382:microbiology*; D005227:Fatty Acids / Q000627:therapeutic use; D006801:Humans; D016712:Mupirocin; D009297:Nasal Mucosa / Q000382:microbiology*; D009824:Ointments; D010865:Pilot Projects; D012008:Recurrence; D006435:Renal Dialysis; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D009824:Ointments; D016712:Mupirocin