[Various biochemical indicators of the cerebrospinal fluid in acute carbophos poisoning].
The study was performed to evaluate the levels of some enzymes (AST, ALT, HGTP, LDG) and free amino acids (aspartic, glutaminic, glycine, isoleucine, leucine) in liquor of 37 subjects who got poisoned with a Malathion insecticide. Their condition was diagnosed as moderate and severe. The liquor was obtained on poisoning day 1, 3, 10, 14 and 21. The liquor levels of enhancement mediatory amino acids, aspartic and glutaminic, rise early in poisoning, while concentration of inhibition mediator glycine tends to decline. Progress of intoxication brings about a rise in LDG and GGTP activity attributed to a membranotoxic effect of the insecticide.
I P
IP
Kolesnichenko
T V
TV
Rodionova
T V
TV
Somova
I S
IS
Dolgo-Saburova
D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000134:cerebrospinal fluid*; D000596:Amino Acids / Q000134:cerebrospinal fluid*; D001219:Aspartate Aminotransferases / Q000134:cerebrospinal fluid*; D004789:Enzyme Activation / Q000187:drug effects; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D008294:Malathion / Q000134:cerebrospinal fluid / Q000506:poisoning*; D008875:Middle Aged; D013406:Suicide, Attempted; D005723:gamma-Glutamyltransferase / Q000134:cerebrospinal fluid*
D000596:Amino Acids; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D008294:Malathion
Nekotorye biokhimicheskie pokazateli tserebrospinal'noĭ zhidkosti pri ostrom otravlenii karbofosom.