Protective property of azelastine against histamine challenge of rhinal mucosa in domestic pigs.
In anaesthetized domestic pigs a filter paper sampling technique was applied to estimate basal and histamine induced nasal secretion. Histamine (0.2 mg/nostril) increased secretion more than twofold, a dose of 2 mg/nostril more than 10 fold. Intranasally instilled azelastine (A-5610, CAS 58581-89-8) prevented this histamine induced rhinorrhea without reduction of basal secretion. The protective effect remained for more than 2 h even when histamine challenge was repeated.
Stroman
F
F
Asta Pharma AG, Department of Pharmacology, Frankfurt/Main, Fed. Rep. of Germany.
Herold
H
H
Szelenyi
I
I
D000818:Animals; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism; D010793:Phthalazines / Q000494:pharmacology*; D013552:Swine
D006634:Histamine H1 Antagonists; D010793:Phthalazines; D006632:Histamine; C020976:azelastine