[The effect of narcotic analgesics on the central nervous system as an index of their drug addiction potential].
The relationship between the average effective doses causing disturbances of the statokinetic reflex and the average effective doses of the analgesic and hyperthermic actions of morphine, fentanyl, codeine and tilidine was studied in the experiments on Wistar rats. The effective analgesic and hyperthermic doses of morphine (the agent with the highest drug-addiction properties) approach the dose inducing coordination disorders. In this respect fentanyl and codeine are close to morphine. The effective doses of tilidine (the agent with the lowest drug-addiction properties among the studied agents) possess significant differences. The importance of the relationship between the mentioned effective doses and the drug-addiction properties of the analgesics.
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Bantutova
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Iakimova
D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D007928:Lethal Dose 50; D008297:Male; D009293:Opioid-Related Disorders / Q000209:etiology*; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000701:Analgesics, Opioid
Vliianie narkoticheskikh anal'getikov na tsentral'nuiu nervnuiu sistemu kak pokazatel' ikh toksikomanicheskogo potentsiala.