Vasodilator responses following intracranial stimulation of the trigeminal, facial and glossopharyngeal nerves in the cat gingiva.
The effects of electrical stimulation of the trigeminal, facial and glossopharyngeal nerves on gingival blood flow in the cat were studied. The intracranial part of these nerves was stimulated electrically, and gingival blood flow was measured by the laser Doppler technique. Electrical stimulation of the trigeminal, facial and glossopharyngeal nerves caused blood flow to increase in the ipsilateral gingiva both with the cranial nerve intact and after cutting it to the medulla. Stimulation of the distal cut ends of the facial and glossopharyngeal nerves elicited an increase in blood flow but no increase in systemic blood pressure. Pretreatment with hexamethonium reduced the increase in blood flow elicited by electrical stimulation of the facial and glossopharyngeal nerves, but had no effect on that elicited by stimulation of the trigeminal nerve. In contrast, pretreatment with tripelennamine attenuated the trigeminal nerve-stimulated blood flow increase, but not that elicited by stimulation of the facial and glossopharyngeal nerves. Atropine, propranolol and phentolamine had no effect on these responses. These results suggest that the autonomic nervous system, particularly the parasympathetic nervous system, is responsible for the blood flow increase elicited by facial and glossopharyngeal nerve stimulation, and that the trigeminal nerve-stimulated blood flow increase is induced by antidromic vasodilatation of the trigeminal sensory nerve.
Department of Physiology, Tohoku University School of Dentistry, Sendai, Japan.
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Izumi
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Karita
D000818:Animals; D001340:Autonomic Nerve Block; D001794:Blood Pressure / Q000502:physiology; D002415:Cats; D004558:Electric Stimulation; D005154:Facial Nerve / Q000502:physiology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D005881:Gingiva / Q000098:blood supply*; D005930:Glossopharyngeal Nerve / Q000502:physiology*; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D012039:Regional Blood Flow / Q000502:physiology; D014276:Trigeminal Nerve / Q000502:physiology*; D014309:Tripelennamine / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*
D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D006634:Histamine H1 Antagonists; D014309:Tripelennamine; D018738:Hexamethonium