Acute exposure to cadmium causes time-dependent liver injury in rats.
1. Serum enzymes activities of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT), after intraperitoneal injection of CdCl2 showed a maximum increase at 12 hours, contrary to the alkaline phosphatase (ALP) that showed a permanent decrease by that time. 2. Cadmium concentration in liver showed an increase at 6 and 12 hours, a decrease at 18, and a re-establishment to the initial values at 24 hours. 3. Liver microsomal membrane fluidity showed an increase at 6 hours followed by a decrease within 24 hours. Free radical generation was decreasing gradually up to 24 hours. 4. Gradually increasing changes were observed from the histological study.
Theocharis
S
S
Department of Experimental Physiology, School of Medicine, University of Athens, Greece.
Margeli
A
A
Fasitsas
C
C
Loizidou
M
M
Deliconstantinos
G
G
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D019256:Cadmium Chloride; D056486:Chemical and Drug Induced Liver Injury; D007425:Intracellular Membranes / Q000502:physiology; D007700:Kinetics; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D008297:Male; D008560:Membrane Fluidity; D008862:Microsomes, Liver / Q000648:ultrastructure; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains
D002104:Cadmium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D019256:Cadmium Chloride