The Shwartzman response: a model of ICAM-1 dependent vasculitis.
The local Shwartzman response was produced in rabbits by the intradermal injection of endotoxin, followed 24 h later by intravenous zymosan. Hemorrhagic lesions developed in the prepared skin sites. We quantitated the Shwartzman-induced hemorrhage with autologous 99mTc-erythrocytes. We show that the development of the Shwartzman response depends on both leukocyte membrane CD18 glycoprotein activity as well as the participation of intercellular adhesion molecule-1 (ICAM-1). We discuss the possibility that the common property shared by the agents capable of preparing the skin for the Shwartzman response is the ability to induce ICAM-1 expression.
Argenbright
L W
LW
Department of Pharmacology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.
Barton
R W
RW
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1; D008297:Male; D011817:Rabbits; D012790:Shwartzman Phenomenon / Q000209:etiology*; D014657:Vasculitis / Q000209:etiology*
D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1