Short-term effects of diethylaminoethyl-dextran on postprandial gastrointestinal hormone responses in man.
The effects of oral diethylaminoethyl-dextran (3 g total), taken 30 min before a standard mixed test meal, on plasma glucose, total cholesterol, triglycerides, total lipids, gastrin-like immunoreactivity, bombesin-like immunoreactivity, gastric-inhibitory-polypeptide-like immunoreactivity and neurotensin-like immunoreactivity were evaluated in eight healthy volunteers following a double-blind protocol. Incremental peak plasma concentrations of total lipids and triglycerides were significantly reduced by pretreatment with diethylaminoethyl-dextran pretreatment, while peaks of plasma glucose and total cholesterol were not significantly affected. Diethylaminoethyl-dextran also inhibited postprandial gastrin-like gastric-inhibitory-polypeptide-like and neurotensin-like immunoreactivity; by contrast, bombesin-like immunoreactivity was not significantly modified. The present study indicates that diethylaminoethyl-dextran is able to regulate some postprandial metabolic and hormonal parameters in man; consequently it might be useful in the treatment of hyperlipoproteinaemia and obesity.
Institute of Veterinary Internal Medicine, University of Pisa, Italy.
G
G
Soldani
A
A
Della Longa
G
G
Mengozzi
S
S
Demi
L
L
Intorre
F
F
Martelli
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003637:DEAE-Dextran / Q000494:pharmacology*; D003911:Dextrans / Q000494:pharmacology*; D005260:Female; D005502:Food; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009496:Neurotensin / Q000097:blood; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D003911:Dextrans; D005755:Gastrins; D005768:Gastrointestinal Hormones; D008055:Lipids; D014280:Triglycerides; D009496:Neurotensin; D005749:Gastric Inhibitory Polypeptide; D003637:DEAE-Dextran; D002784:Cholesterol