Bilateral gonadoblastoma producing steroid hormones in a patient with 45,X/46,XY gonadal dysgenesis.
A case of bilateral gonadoblastoma in a phenotypic female with 45,X/46,XY gonadal dysgenesis is presented. Hormonal investigations revealed that serum testosterone, estradiol and beta-human chorionic gonadotropin decreased following excision of the tumors, but follicle-stimulating hormone and luteinizing homrone levels increased further. Immunohistochemical staining for testosterone and estradiol was positive in both Leydig and lutein-like cells in the tumor. It is suggested that gonadoblastoma is capable of producing testosterone and estradiol, and Leydig or lutein-like cells may be the actual source of these steroid hormones.
Fukamatsu
Y
Y
Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
Tsukahara
Y
Y
Hayashi
S
S
Yoshikawa
F
F
Fukuta
T
T
D000293:Adolescent; D006063:Chorionic Gonadotropin / Q000378:metabolism; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004407:Dysgerminoma / Q000378:metabolism* / Q000473:pathology; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006060:Gonadal Dysgenesis, Mixed / Q000150:complications* / Q000473:pathology; D006066:Gonads / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D009378:Neoplasms, Multiple Primary / Q000378:metabolism* / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D013739:Testosterone; D004958:Estradiol