Inhibition of antibody formation in intrauterine varicella virus infection.
Serological and clinical follow-up of 35 pregnancies complicated with varicella-zoster virus (VZV) infection showed insufficient antibody response in 2 children with undetectable IgG levels in ELISA and indirect haemagglutination (IHA) test. Secondary infection with VZV at the age of 4 1/2 years of the first child and inapparent infection at the age of 4 years and 3 months in the second child born with congenital varicella lead to seroconversion against VZV. None of the children in question developed acquired varicella primoinfection. We believe that a temporary specific inhibition of antibody formation was caused by transplacentar transmission of maternal antibodies into foetal circulation.
Institute of Hygiene and Epidemiology, Prague, Czecho-Slovakia.
J
J
Trlifajová
D000914:Antibodies, Viral / Q000096:biosynthesis*; D002644:Chickenpox / Q000276:immunology* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000382:microbiology; D014591:Uterine Diseases / Q000276:immunology* / Q000382:microbiology
D000914:Antibodies, Viral