[Development of an infection in monkeys as a result of their sequential natural and experimental exposure to the hepatitis A virus].
The development of spontaneous outbreak of hepatitis A (HA) among African green monkeys kept under strict isolation conditions was studied. It was shown that in the case of introduction of HAV the infection involved all the susceptible monkeys, running a course with and without any increase in the level of activity of serum alanine aminotransferase (ALT) After inoculation of commercial gamma-globulin only the infection without the ALT activity increase developed and some monkeys had no signs of HA at all. Experimental reinfection with HAV was produced in monkeys having anti-HAV titres of less than or equal to 1:3500.
Zamiatina
N A
NA
Andzhaparidze
A G
AG
Balaian
M S
MS
Sobol'
A V
AV
Titova
I P
IP
Karetnyĭ
Iu V
IuV
Poleshchuk
V F
VF
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D005243:Feces / Q000382:microbiology; D006506:Hepatitis A / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D006508:Hepatitis Antibodies / Q000008:administration & dosage / Q000097:blood; D006507:Hepatovirus / Q000276:immunology / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000032:analysis; D008099:Liver / Q000382:microbiology; D008992:Monkey Diseases / Q000209:etiology* / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D012008:Recurrence; D013997:Time Factors; D005719:gamma-Globulins / Q000008:administration & dosage
D006508:Hepatitis Antibodies; D007075:Immunoglobulin M; D005719:gamma-Globulins; D000410:Alanine Transaminase
Razvitie infektsii u obez'ian v rezul'tate posledovatel'nogo estestvennogo i éksperimental'nogo zarazheniia ikh virusom gepatita A.