Glutathione peroxidase deficiency and childhood seizures.
4 children with intractable seizures, repeated infections, and intolerance to anticonvulsants had evidence of glutathione peroxidase deficiency. 2 had low intracellular enzyme activity but normal blood selenium and high plasma glutathione peroxidase concentrations. The other 2 had low intracellular glutathione peroxidase activity with low circulating glutathione peroxidase and selenium concentrations. The clinical state of the children improved after discontinuation of anticonvulsant medication and selenium substitution.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
G F
GF
Weber
P
P
Maertens
X Z
XZ
Meng
C E
CE
Pippenger
D000927:Anticonvulsants / Q000009:adverse effects; D005979:Glutathione Peroxidase / Q000097:blood / Q000172:deficiency*; D005980:Glutathione Reductase / Q000172:deficiency*; D006801:Humans; D007223:Infant; D007424:Intracellular Fluid / Q000201:enzymology; D008297:Male; D012008:Recurrence; D012640:Seizures / Q000188:drug therapy / Q000201:enzymology*; D012643:Selenium / Q000097:blood / Q000627:therapeutic use
D000927:Anticonvulsants; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D012643:Selenium