[Stimulation of respiration with Piladox in experimental and clinical conditions during administration of drugs for general anesthesia].
Experimental and clinical studies of the agent Piladox (RGH 2202) were conducted. Experiments on animals (rats, rabbits, mice) demonstrated that Piladox possesses the property of restoring respiration inhibited by narcotic analgesics and some general anesthetics as well as the respiratory-de-priming effect of acute blood loss and is a more effective stimulator of the respiratory center than cordiamine (nikethamide) or corasol. Clinical study of Piladox in 75 patients showed that intravenous infusion of 1 mg/kg of the agent in the awakening period produced a stimulating effect on respiration through increase of its frequency and increase of the respiratory volume. The minute respiratory volume in this case was even greater than the initial values, whereas the CO2 content in the blood and expired air reached the initial level. The hemodynamic values in this period remained generally stable. Piladox does not change the antinociceptive effect of the narcotic analgesics and analgesia in the immediate postoperative period when combined general anesthesia is applied.
Sachkov
V I
VI
Abramov
Iu B
IuB
Voĭnov
V A
VA
Chichenkov
O N
ON
Leshchenko
V V
VV
Nammur
F
F
D000768:Anesthesia, General / Q000009:adverse effects*; D000818:Animals; D001463:Barbiturates / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D005260:Female; D005283:Fentanyl / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced / Q000517:prevention & control*; D007866:Leg / Q000098:blood supply*; D008297:Male; D051379:Mice; D008875:Middle Aged; D008954:Models, Biological; D009020:Morphine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects* / Q000502:physiology; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014652:Vascular Diseases / Q000503:physiopathology / Q000601:surgery*
D001463:Barbiturates; D013973:Thyrotropin-Releasing Hormone; D009020:Morphine; C055448:posatirelin; D005283:Fentanyl
Stimuliatsiia dykhaniia Piladoksom v éksperimente i klinike v usloviiakh primeneniia sredstv dlia obshcheĭ anestezii.