Effects of somatostatin-14 and its analogs on the (Ca,Mg)ATPase in the rat anterior pituitary.
The effects of somatostatin-14 and its biologically active analogs, RC-160 and SMS 201-995, on (Ca,Mg)ATPase activity in vitro were studied in homogenates of anterior pituitary cells. It was found that somatostatin inhibited the (Ca,Mg)ATPase activity in the anterior pituitary and somatostatin analogs exerted slight biphasic effects on the calcium pump activity. The effects of specific brain (Ca,Mg)ATPase inhibitors, VOSO4 and LaCl3, were also studied in vitro. Neither VOSO4 nor LaCl3 enhance the inhibition of calcium pump activity caused by somatostatin. It is suggested that somatostatin may mediate its action in pituitary cells, among others, by the regulation of (Ca,Mg)ATPase activity.
Department of Experimental Endocrinology, Medical Academy of Lodz, Poland.
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Lachowicz
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Pawlikowski
D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D007700:Kinetics; D007811:Lanthanum / Q000494:pharmacology; D008297:Male; D015282:Octreotide / Q000494:pharmacology; D010903:Pituitary Gland, Anterior / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors
C028521:lanthanum chloride; C051458:vapreotide; D013004:Somatostatin; D007811:Lanthanum; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D015282:Octreotide