[Evaluation of the inhibition of allergen-specific and nonspecific skin responses by topical oxatomide].
A double blind study against placebo was carried out in order to assess the inhibition induced by oxatomide gel in specific and aspecific cutaneous responses (prick test). Twenty allergic patients (8 M, 12 F) aged between 15 and 59 years (average 31) were treated for 7 days with oxatomide gel 5% or with placebo (2 applications a day). The results show a significant reduction of itching and of wheal size (considering either major diameter and area) only in the oxatomide group (p less than 0.01 between times and p less than 0.001 between treatments), whereas among controls itching remained unchanged and wheal size increased. During the follow-up a gradual return of wheal size to initial values in the patients treated was observed.
Sacerdoti
G
G
Servizio Medico Puropharma, Milano.
Cardone
M
M
Nicora
M
M
D000293:Adolescent; D000328:Adult; D000485:Allergens; D004311:Double-Blind Method; D005260:Female; D005782:Gels; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D012130:Respiratory Hypersensitivity / Q000175:diagnosis / Q000188:drug therapy*; D012882:Skin Tests
D000485:Allergens; D005782:Gels; D006634:Histamine H1 Antagonists; D010879:Piperazines; D006632:Histamine; C015408:oxatomide
Valutazione dell'inibizione delle risposte cutanee allergene-specifiche e non da parte dell'oxatomide per uso topico.