Inhibitory effect of galanin on basal and pentagastrin-stimulated gastric acid secretion in rats.
The dose-dependent effects of galanin on basal and pentagastrin-stimulated gastric acid secretion in pentobarbital-anesthetized rats were examined. Intravenous infusion of galanin at doses of 0.31, 0.62, 1.25, 1.87, 3.11, and 6.22 nmol/kg-1/h-1 into pentagastrin-stimulated rats produced a diminution in gastric acid secretion which was maximal (54.7%) at the level of the 1.87 nmol/kg-1/h-1 dose. Furthermore, the effect was biphasic, since both lower and higher doses of peptide were less effective. At the optimum concentration of 1.87 nmol/kg-1/h-1 galanin also inhibited basal gastric acid secretion. We conclude that endogenous galanin might be involved in the physiologic regulation of gastric acid secretion.
Yagci
R V
RV
Dept. of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112.
Alptekin
N
N
Rossowski
W J
WJ
Brown
A
A
Coy
D H
DH
Ertan
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D019004:Galanin; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical
D009479:Neuropeptides; D010455:Peptides; D019004:Galanin; D010418:Pentagastrin