Relationship between immunoglobulin allotypes and susceptibility to nasopharyngeal carcinoma in Malaysia.
The relationship between immunoglobulin allotypes and risk of developing nasopharyngeal carcinoma was examined in a comparative study of 50 Chinese cases and 140 Chinese controls and 50 Malay cases and 79 Malay controls residing in Malaysia. Although the most common Gm phenotype was elevated in both Chinese and Malay nasopharyngeal carcinoma patients compared to their controls, there were no significant differences between cases and controls in the distribution of Gm haplotypes in either population. There were no differences between cases and controls in the distribution of Km alleles in either population. Thus a previously reported association of Km(1) with increased nasopharyngeal carcinoma risk in Tunisia is not confirmed in two Mongoloid populations in Malaysia.
Biostatistics Branch, National Cancer Institute, Bethesda, Maryland 20892.
R E
RE
Tarone
P H
PH
Levine
M
M
Yadav
J P
JP
Pandey
D002681:China / Q000208:ethnology; D004198:Disease Susceptibility / Q000276:immunology; D000939:Epitopes / Q000235:genetics* / Q000276:immunology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics* / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000235:genetics* / Q000276:immunology; D008296:Malaysia / Q000208:ethnology; D009303:Nasopharyngeal Neoplasms / Q000208:ethnology / Q000276:immunology*; D010641:Phenotype
D000939:Epitopes; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains; D007145:Immunoglobulin kappa-Chains