Changes in K(+)-induced contractions in ileal longitudinal smooth muscle of guinea-pig, induced by monoiodoacetic acid.
The ileal responses to 40 mM [K+]o were changed in the period after administration of monoiodoacetic acid (IAA). The phasic contraction to K+ appeared in the period before the development of a rigor, after the administration of 1 mM IAA. However, the response to K+ was absent during the development of a rigor to IAA during decreasing tissue ATP concentrations.
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University, Japan.
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Nasu
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Narimatsu
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Shibata
D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D007461:Iodoacetates / Q000494:pharmacology*; D019807:Iodoacetic Acid; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology*
D007461:Iodoacetates; D011188:Potassium; D019807:Iodoacetic Acid