Effects of imipenem and cefmetazol on lymphocyte receptors CD2, Fc and C3b of complement.
We studied the influence of Imipenem and Cefmetazol (50 mg/l) on lymphocyte receptors CD2, Fc and C3b of complement. The lymphocytes were obtained from human blood and mice axillary ganglions. Cefmetazol significantly increases the binding capacity of human lymphocyte receptors CD2 to sheep red blood cells while Imipenem does not alter this binding. The number of Fc lymphocyte receptors for the constant fraction of IgG is found to be significantly increased when the lymphocytes are incubated in vitro with Imipenem and Cefmetazol. When the lymphocytes are treated with these antibiotics there is an increase in the receptors capable of binding to fraction C3b of the complement.
University of Extremadura, Faculty of Science, Department of Physiology, Badajoz, Spain.
C
C
Barriga Ibars
E
E
Muriel
P
P
Benitez
M
M
de la Fuente
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000187:drug effects; D001665:Binding Sites; D018801:CD2 Antigens; D015311:Cefmetazole / Q000494:pharmacology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011951:Receptors, Complement / Q000187:drug effects; D017463:Receptors, Complement 3b; D011961:Receptors, Fc / Q000187:drug effects; D011971:Receptors, Immunologic / Q000187:drug effects*
D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D011961:Receptors, Fc; D011971:Receptors, Immunologic; D015311:Cefmetazole; D015378:Imipenem