Development of Ki-1 lymphoma in a child suffering from multicentric reticulohistiocytosis.
We report a case of Ki-1 lymphoma that developed in a 16-year-old youth who had suffered from multicentric reticulohistiocytosis for 10 years. Over the past 3 years he had had a peculiar sclerosing lesion of the leg for which oral prednisone 5 mg daily was tried for one year, with a moderate effect. He developed a marked swelling of the inguinal lymphadenopathy on the same side as the affected leg lesion, which also developed a prominent swelling of the skin surrounding the sclerosed area. Immunohistochemical analysis of the lymph node biopsy revealed the features of Ki-1 lymphoma. This is the first case of association of multicentric reticulohistiocytosis with Ki-1 lymphoma.
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Y
Y
Kuramoto
O
O
Iizawa
J
J
Matsunaga
N
N
Nakamura
H
H
Tagami
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006119:Groin; D054747:Histiocytic Sarcoma / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D017730:Ki-1 Antigen; D007866:Leg; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen