Biodistribution and magnetic resonance imaging of cross-linked DTPA polysaccharides.
Large polysaccharide complexes, cross-linked with DTPA and chelated with gadolinium have been tested for various potential uses for magnetic resonance imaging (MRI) in rats. Biodistribution and pharmacokinetic data for several of the soluble polymers are presented and compared with Gd-DTPA and GdCl3. By varying the initial polysaccharide length and ratio of DTPA to glucose units, polymers of molecular weights (mol wt) from 17,000 to several million were formed, giving soluble material, gels, or particles. The larger polymers (mol wt greater than 100,000) demonstrate prolonged enhancement of the intravascular space, striking renal enhancement, and moderate hepatic uptake. Small particulate material (less than 10 microns) was also successfully used for intravascular enhancement. The material is metabolized and excreted in urine.
Department of Radiology, University of Arizona, Tucson.
W A
WA
Gibby
J
J
Billings
J
J
Hall
T W
TW
Ovitt
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D003432:Cross-Linking Reagents; D003911:Dextrans; D005682:Gadolinium / Q000493:pharmacokinetics*; D019786:Gadolinium DTPA; D006207:Half-Life; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000493:pharmacokinetics*; D004369:Pentetic Acid / Q000493:pharmacokinetics*; D011108:Polymers; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D003287:Contrast Media; D003432:Cross-Linking Reagents; D003911:Dextrans; D009942:Organometallic Compounds; D011108:Polymers; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA