Polyribonucleotide-anthraquinone interactions: in vitro antiviral activity studies.
Twelve anthraquinones (AQ) were evaluated for their ability to potentiate the antiviral activity of poly r(A-U) using a human foreskin fibroblast-vesicular stomatitis virus bioassay in which the AQ was combined with 0.2 mM poly r(A-U) to produce an AQ/ribonucleotide ratio of 1/4. Poly r(A-U) and the AQ alone were not effective antiviral agents. Five of the twelve AQs tested, mitoxantrone, adriamycin, ametantrone, carminic acid and daunomycin, enhanced the antiviral activity of poly r(A-U) 9- to 13-fold. The interferon-inducing activity of the five active AQ/poly r(A-U) combinations was equal to the sum of the interferon-inducing activities of their constituents. These five AQs appear to potentiate the antiviral activity of poly r(A-U) without superinduction of interferon.
Jamison
J M
JM
Department of Chemistry, Kent State University, Ohio 44242.
Krabill
K
K
Flowers
D G
DG
Tsai
C C
CC
D000880:Anthraquinones / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002329:Carmine / Q000031:analogs & derivatives / Q000494:pharmacology; D002478:Cells, Cultured; D003630:Daunorubicin / Q000494:pharmacology; D004357:Drug Synergism; D005347:Fibroblasts; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D015394:Molecular Structure; D011063:Poly A-U / Q000378:metabolism / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
D000880:Anthraquinones; D000998:Antiviral Agents; D011063:Poly A-U; D007372:Interferons; D002329:Carmine; D003630:Daunorubicin