Effects of prazosin HCl on micturition disturbance associated with benign prostatic hypertrophy and bladder neck contracture.
The effects of alpha 1-adrenergic blockade with prazosin HCl were examined in 28 patients with benign prostatic hypertrophy and bladder neck contracture. The patients received 2-3 mg of prazosin HCl daily administered orally. Improvement in subjective symptoms was observed in 75% of the patients. We evaluated clinical effects as the minimum time of micturition (calculated as the ratio of voided volume/maximum flow rate) for voided volumes less than 200 ml and the maximum flow rates and average flow rates for voided volumes over 200 ml. Evaluation of the findings on a flow rate nomogram revealed improvement in maximum flow rates and average flow rates in 41% of the patients. Side effects such as dizziness developed in only 1 patient.
Kohama
Y
Y
Department of Urology, Kochi Medical School, Nangoku, Japan.
Watanabe
H
H
Sen
Y
Y
Yamamoto
Y
Y
Morioka
M
M
Fujita
Y
Y
D006801:Humans; D008297:Male; D011224:Prazosin / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000188:drug therapy; D014524:Urethral Obstruction / Q000188:drug therapy* / Q000209:etiology; D001748:Urinary Bladder Neck Obstruction / Q000150:complications* / Q000188:drug therapy; D014555:Urination Disorders / Q000188:drug therapy / Q000209:etiology; D014563:Urodynamics / Q000187:drug effects
D011224:Prazosin