Identification of an inhibitor of neovascularization from cartilage.
Certain tissues such as cartilage are resistant to vascular invasion, yet no single tissue-derived molecule that can inhibit angiogenesis has been reported. A protein derived from cartilage was purified that inhibits angiogenesis in vivo and capillary endothelial cell proliferation and migration in vitro in three separate bioassays. This protein is also an inhibitor of mammalian collagenase. These findings may help elucidate the mechanisms by which neovascularization is controlled in both normal and pathological states.
Department of Surgery, Children's Hospital Medical Center, Boston, MA 02115.
M A
MA
Moses
J
J
Sudhalter
R
R
Langer
D000302:Adrenal Cortex / Q000098:blood supply; D000482:Allantois / Q000098:blood supply; D000595:Amino Acid Sequence; D043925:Angiogenesis Inducing Agents / Q000037:antagonists & inhibitors*; D020533:Angiogenesis Inhibitors; D000818:Animals; D001681:Biological Assay; D002196:Capillaries / Q000166:cytology; D002356:Cartilage / Q000032:analysis*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply; D004730:Endothelium, Vascular / Q000166:cytology; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006131:Growth Inhibitors; D008969:Molecular Sequence Data; D009389:Neovascularization, Pathologic; D011506:Proteins / Q000302:isolation & purification / Q000494:pharmacology*
D043925:Angiogenesis Inducing Agents; D020533:Angiogenesis Inhibitors; D006131:Growth Inhibitors; D011506:Proteins; D005346:Fibroblast Growth Factors