Nonorgan-specific autoantibodies in individuals infected with type 1 human immunodeficiency virus.
Fifty-six human immunodeficiency virus-1-positive asymptomatic carriers were tested for the presence of a variety of nonorgan-specific autoantibodies. Antinuclear antibodies were detected in 34 sera, of which 27 were directed to the mitotic spindle apparatus and all were of the IgG isotype. Anti-Golgi complex, anti-centriole, and anti-vimentin antibodies were also present in 20.4, and 4 sera, respectively. Ten patients had less than 500 CD4-carrying T lymphocytes per cubic millimeter. Nine of them had more than one autoantibody. No correlation could be demonstrated between the number of autoantibodies and the level of serum immunoglobulins.
Department of Internal Medicine, Brest University Medical School, France.
A
A
Gentric
M
M
Blaschek
C
C
Julien
J
J
Jouquan
Y
Y
Pennec
J M
JM
Berthelot
D
D
Mottier
R
R
Casburn-Budd
P
P
Youinou
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002353:Carrier State / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007136:Immunoglobulins