Furosemide kinetics and dynamics in rats and humans.
1. Increasing doses of furosemide (F) were given intravenously to rats and humans and initial pharmacokinetics and pharmacodynamics were compared. 2. Weight-related initial renal excretion rate of F was twice as high in rats and serum concentration at 30 min was twice as high in humans (P less than 0.01). 3. Volume of distribution for F was 44% larger in rats (P less than 0.01). 4. Maximal weight-related diuretic and natriuretic responses were, like the theoretical maximal efficiency, 5-6 times higher in the rat. The potency was 230 times lower in the rats. 5. On a molecular basis species differences in kinetics disappeared when standardization was based on ERPF and species differences in dynamics disappeared when standardization was based on GFR.
Division of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Denmark.
F
F
Andreasen
I
I
Tietze
F A
FA
Hansen
J S
JS
Petersen
S
S
Christensen
E
E
Steiness
D000818:Animals; D001835:Body Weight / Q000502:physiology; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005665:Furosemide / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D009318:Natriuresis / Q000187:drug effects; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D005665:Furosemide