The effect of high energy electron irradiation on blood-brain barrier permeability to haloperidol and stobadin in rats.
The heads of rats were irradiated by 4 MeV electrons in doses 90, 180, and 360 Gy. The observed times of deaths ranged 120-600, 60-420, and 150-370 min after 90, 180, and 360 Gy, respectively. A dose dependent decrease of the brain uptake index of haloperidol was observed 1 and 3 h post radiation. On the other hand an increased brain uptake index was found for stobadin after head irradiation with doses of 180 and 360 Gy. Regional cerebral blood flow, blood pressure, and heart rate were not significantly altered in the period following irradiation with 180 Gy. The observed changes in blood-brain barrier (BBB) permeability seem to be the result of the damaged function of morphological structures forming the BBB rather than altered regional blood flow.
Institute of Preventive and Clinical Medicine, Bratislava, CSFR.
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Trnovec
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Volenec
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Bezek
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Kállay
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Durisová
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Scasnár
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Kubu
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Svoboda
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics*; D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D002243:Carbolines / Q000493:pharmacokinetics*; D002560:Cerebrovascular Circulation / Q000528:radiation effects; D006220:Haloperidol / Q000493:pharmacokinetics*; D010539:Permeability; D051381:Rats
D000889:Anti-Arrhythmia Agents; D014150:Antipsychotic Agents; D002243:Carbolines; D006220:Haloperidol; C100106:dicarbine