[The expression of P-glycoprotein in leukemia P388 cells with induced doxorubicin resistance].
beta-D-galactose-containing glycoproteins were prepared from cells P-388 leukemia and from P-388 leukemia cells with induced resistance to doxorubicin. It was shown by HPLC method that plasma membranes from resistant cells contain 4-4.5% P-glycoproteins and plasma membranes from sensitive cells contain P-glycoproteins about 10 times lower.
Sukhanov
V A
VA
D'iakov
V L
VL
Lalaev
V V
VV
Iakh'iaev
A V
AV
Voronkova
I M
IM
Donenko
F V
FV
Borovkova
N B
NB
Moroz
L V
LV
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000037:antagonists & inhibitors*; D004351:Drug Resistance; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D015151:Immunoblotting; D007941:Leukemia P388 / Q000235:genetics* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics* / Q000302:isolation & purification; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics* / Q000302:isolation & purification; D012995:Solubility
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D004317:Doxorubicin
Ekspressiia P-glikoproteina v kletkakh leĭkoza P 388 s indutsirovannoĭ ustoĭchivost'iu k doksorubitsinu.