Lack of C-erbB-2 protein expression in pulmonary carcinoid tumours.
To determine if amplification of the C-erb-B2 proto-oncogene could be correlated with prognosis in carcinoid tumours, 49 pulmonary carcinoid tumours (26 typical, 23 atypical) were examined using a polyclonal antibody to the C-terminal peptide of the C-erb-B2 protein sequence. No C-erb-B2 gene product could be shown: the demonstration of C-erb-B2 does not seem to help, therefore, in determining diagnosis or prognosis in pulmonary carcinoid tumours.
Department of Pathology, Wythenshawe Hospital, Manchester.
N
N
Wilkinson
P S
PS
Hasleton
S
S
Wilkes
A
A
Quigley
D014408:Biomarkers, Tumor / Q000032:analysis*; D002276:Carcinoid Tumor / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry*; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000032:analysis*; D011519:Proto-Oncogenes / Q000502:physiology*; D018719:Erb-b2 Receptor Tyrosine Kinases
D014408:Biomarkers, Tumor; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; C000715470:MAS1 protein, human