Marked rapid alterations in nocturnal pineal serotonin metabolism in mice and rats exposed to weak intermittent magnetic fields.
Adult AMES mice and male Sprague Dawley rats were exposed to an artificial magnetic field, generated by Helmholtz coils. 3.5 hours after the onset of darkness the coils were activated for one hour resulting in an inversion of the horizontal component of the earth's magnetic field. The coils were activated and deactivated at 5 min intervals during the 1 hour exposure period. In both mice and rats, the levels of serotonin in the pineal were markedly increased by the exposure. In rats, an increase of pineal 5-hydroxyindole acetic acid and a decrease of the activity of the pineal enzyme serotonin-N-acetyltransferase also was observed. However, pineal and serum melatonin levels were not altered. The results indicate that the metabolism of serotonin in the pineal is quickly affected by the exposure of animals to a magnetic field.
Lerchl
A
A
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284-7762.
Nonaka
K O
KO
Stokkan
K A
KA
Reiter
R J
RJ
D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism; D002940:Circadian Rhythm; D004574:Electromagnetic Fields; D055590:Electromagnetic Phenomena; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000378:metabolism; D051379:Mice; D010870:Pineal Gland / Q000378:metabolism* / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013045:Species Specificity
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin