The hairless mouse as a model for study of local and systemic atrophogenic effects following topical application of corticosteroids.
The hairless mouse has been used as a model to distinguish between local and systemic atrophogenic effects of topical steroids. Hydrocortisone-17-butyrate, betamethasone-17-valerate, budesonide and clobetasol-17-propionate were applied topically daily for 21 days. Skinfold thickness and dermal DNA synthesis of treated and untreated skin were evaluated as parameters of local and systemic atrophogenicity. Further, body weight gain and thymus weight were assessed as markers of systemic activity. With respect to local effects, skin thickness and dermal DNA synthesis both proved to be good parameters. Of the systemic parameters, thymic involution and body weight gain paralleled quite well the skin thinning on the untreated side. The results confirmed the potency differences of the steroids. Furthermore, they emphasize the usefulness of the hairless mouse to assess the relative safety with respect to local and systemic side effects of chronically applied topical corticosteroids.
Department of Biological Drug Research, Royal Gist-brocades N.V., Delft, The Netherlands.
W E
WE
van den Hoven
T P
TP
van den Berg
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C
Korstanje
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001284:Atrophy; D004247:DNA / Q000096:biosynthesis; D004195:Disease Models, Animal; D005938:Glucocorticoids; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D012885:Skinfold Thickness
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D004247:DNA