The use of an electrically activated valve to control preload and provide maximal muscle blood flow with a skeletal-muscle ventricle.
A new method for optimally loading a skeletal muscle-wrapped pouch to act as a blood pump is described. The method takes advantage of the fact that the high preload pressure required for a forceful contraction needs to be present for only a short time. By using an electrically controlled valve to delay pouch filling until just before muscle contraction, pouch diastolic pressure can be kept low, which in turn maintains a high muscle capillary blood flow. The intrapouch precontraction pressure can be controlled by selecting the appropriate valve-open time (VOT). The pumping capabilities of untrained rectus abdominis and latissimus dorsi muscles were evaluated using a hydraulic circulatory system in a ten dog study (weight range 20-32.7 kg). The afterload was constant at 100 mmHg, and the pouch precontraction pressure, selected by choice of the VOT, was the test variable. It was found that for maximum pouch output, a precontraction pressure of 60-100 mmHg was required, being attained in this hydraulic model with a VOT of 400-500 msec. Typical pouch outputs were 400-600 mL/min with a muscle contraction rate of 40/min. Muscle capillary blood flow, measured with a periarterial electromagnetic flowmeter, varied inversely with pouch diastolic pressure and was near zero during tetanic muscle contraction. In one animal, a pouch output of 200 mL/min or more was maintained for more than 20 hours of continuous pumping without fatigue. In a related experiment, the method was applied to pump blood in a 32.7 kg dog, in which the muscle-wrapped pouch was connected between the descending thoracic aorta and the abdominal aorta. A pouch output of about 400 mL/min was obtained when the muscle was contracted 30 times/min and the VOT was 400 msec. This flow represented about 20% of the animal's cardiac output. This study demonstrates that by delaying pouch filling until just before the muscle is to be contracted, a low pouch diastolic pressure can be maintained, thereby maximizing muscle capillary blood flow and, in turn, providing the best opportunity for prolonged pumping.
Geddes
L A
LA
Hillenbrand Biomedical Engineering Center, Purdue University, W. Lafayette, IN 47907.
Wessale
J L
JL
Badylak
S F
SF
Janas
W
W
Tacker
W A
WA
Voorhees
W D
WD
D000818:Animals; D001243:Assisted Circulation / Q000379:methods*; D003326:Coronary Circulation; D004285:Dogs; D004599:Electric Stimulation Therapy; D006352:Heart Ventricles; D009132:Muscles / Q000098:blood supply / Q000637:transplantation*; D009200:Myocardial Contraction; D011312:Pressure; D012039:Regional Blood Flow; D013524:Surgical Flaps