The influence of myocardial edema after coronary perfusion on left ventricular compliance of isolated ischemic porcine hearts.
The effects of myocardial edema on left ventricular (LV) compliance were studied in the isolated, arrested, hypothermic porcine heart. Myocardial water content, heart weight, and diastolic pressure-volume curves were measured before and after coronary perfusion with different coronary perfusates used to induce edema. Five control hearts without coronary perfusion showed no significant changes in LV compliance after 90 minutes of ischemia as assessed by the exponential ventricular stiffness constants, beta, (0.016 +/- 0.003 vs 0.018 +/- 0.007) and by corresponding volume at 15 mmHg LV filling pressure (LVV-15, 77 +/- 15 ml vs 77 +/- 14 ml). Sixteen pig hearts were divided into three experimental groups; after control measurements, each group underwent coronary perfusion with one liter of a solution of graded osmolarity, 380 (n = 6), 280 (n = 5), or 150 (n = 5) mOsm/L. Following perfusion, measurements were repeated. Each group demonstrated increasing heart weight (233 +/- 16 g vs 259 +/- 24 g, 380 group; 186 +/- 23 g vs 228 = +/- 24 g, 280 group; 190 +/- 20 g vs 254 +/- 34g, 150 group; p less than 0.05) and decreasing LVV-15 (81 +/- 13 mL vs 67 +/- 10 mL, 81 +/- 11 mL vs 57 +/- 16 mL, 77 +/- 14 mL vs 21 +/- 11 mL, respectively, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Surgery, Veterans General Hospital, Taipei, Taiwan R.O.C.
Z C
ZC
Weng
D000818:Animals; D009202:Cardiomyopathies / Q000503:physiopathology*; D003187:Compliance; D004487:Edema / Q000503:physiopathology*; D066298:In Vitro Techniques; D009929:Organ Size; D010477:Perfusion; D013552:Swine; D016277:Ventricular Function, Left