Mapping of the gene coding for the muscle protein nebulin (Neb) to the proximal region of mouse chromosome 2.
Using five different series of recombinant inbred (RI) strains, we have mapped the gene encoding nebulin, a muscle-specific protein. The strain distribution pattern of Neb-specific RFLPs segregating in the RI strains showed significant concordance with those of Pmv-7 and Hc, two loci previously located to proximal mouse Chromosome 2. The gene order, intergene distances, and confidence intervals were determined according to standard maximum likelihood estimates as: centromere-Hc-5.4 cM (1.4 cM-15.4 cM; 95% confidence interval)-Neb-3.6 cM (1.5-6.7 cM)-Pmv-7.
Department of Medicine, McGill University, Montreal, Quebec, Canada.
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Schurr
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Skamene
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Gros
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002503:Centromere; D002874:Chromosome Mapping; D051379:Mice; D008815:Mice, Inbred Strains; D009124:Muscle Proteins / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D012150:Polymorphism, Restriction Fragment Length
D009124:Muscle Proteins; C035620:nebulin