Autoradiographic localisation of NMDA, quisqualate and kainic acid receptors in human spinal cord.
The phencyclidine (PCP) binding site of the N-methyl-D-aspartate receptor, the kainic acid (KA) receptor and the quisqualate (QA) receptor were visualised, using autoradiography in the human spinal cord and the distributions compared with that of benzodiazepine (BDZ) receptors and substance P (SP). All of the receptor types, and SP, were concentrated in lamina II of the dorsal horn, consistent with physiological data indicating that glutamate is a neurotransmitter of primary afferent terminals in the spinal cord.
Department of Anatomy, University of Auckland, School of Medicine, New Zealand.
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Jansen
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Faull
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Dragunow
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Waldvogel
D000328:Adult; D000368:Aged; D001345:Autoradiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010069:Oxadiazoles / Q000378:metabolism*; D016318:Quisqualic Acid; D011963:Receptors, GABA-A / Q000378:metabolism; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism*; D017478:Receptors, Phencyclidine; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism
D010069:Oxadiazoles; D016318:Quisqualic Acid; D011963:Receptors, GABA-A; D018092:Kainic Acid Receptors; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D017478:Receptors, Phencyclidine; D013373:Substance P