Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice.
Prostaglandins and Prostaglandin-analogues were investigated for their ability to protect mice from platelet-activating factor (PAF) induced shock. 75% mortality in female NMRI mice was induced by i.v. injection of 75 micrograms/kg PAF. Nileprost and PGE1, the most potent substances, produced a dose dependent protection against PAF. Iloprost and PGI2 were less effective. PGE2, nalador, flunoprost and U 46619 were neither protective nor deleterious. The strong difference in the effectiveness between the two prostaglandins of the E-series and the poor effect of PGI2 and the PGI2 analogue is remarkable. Flunoprost and U 46619 that increased the TXB2 synthesis or release in two experimental models did not enhance the PAF mortality; TXA2 seems to be only a secondary mediator of the acute PAF-induced death.
Martin Luther University Halle-Wittenberg, Department of Pharmacology and Toxicology, GDR.
K
K
Becker
M L
ML
Herfurth
E
E
Schillinger
W
W
Förster
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology / Q000031:analogs & derivatives; D005260:Female; D016285:Iloprost; D051379:Mice; D010972:Platelet Activating Factor; D011453:Prostaglandins / Q000494:pharmacology*; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D012769:Shock / Q000139:chemically induced* / Q000517:prevention & control
D010972:Platelet Activating Factor; D011453:Prostaglandins; D011465:Prostaglandins, Synthetic; D011464:Epoprostenol; D016285:Iloprost; C038832:nileprost