Up-regulation of dopamine D2 receptor mRNA in rat striatum by chronic neuroleptic treatment.
The effect of prolonged administration of antagonists on rat striatal dopamine D2 receptor binding and mRNA content was examined. Both haloperidol (2 and 4 mg/kg) and sulpiride (10 mg/kg) induced a significant rise in total D2 and D2(444) mRNA level and in Bmax. Regulation of messenger RNA accumulation is thus an important determinant of dopamine D2 receptor density.
Centre de Neurochimie du C.N.R.S., Strasbourg, France.
P
P
Rogue
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A
Hanauer
J
J
Zwiller
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AN
Malviya
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G
Vincendon
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001483:Base Sequence; D015152:Blotting, Northern; D003342:Corpus Striatum / Q000737:chemistry*; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000235:genetics*; D017448:Receptors, Dopamine D2; D013134:Spiperone / Q000378:metabolism; D014316:Tritium; D015854:Up-Regulation
D014150:Antipsychotic Agents; D012333:RNA, Messenger; D011954:Receptors, Dopamine; D017448:Receptors, Dopamine D2; D014316:Tritium; D013134:Spiperone