Physical mapping of 60 DNA markers in the p21.1----q21.3 region of the human X chromosome.
Using a panel of human/rodent somatic cell hybrids and human lymphoblast lines segregating 18 different human X-chromosome rearrangements and deletions, we have assigned 60 DNA markers to the physical map of the X chromosome from Xp21.1 to Xq21.3. Data from Southern blot hybridization and polymerase chain reaction (PCR) amplification assign these markers to 15 primary map intervals. This provides a basis for further long-range cloning and mapping of the pericentromeric region of the X chromosome.
Department of Genetics, Stanford University School of Medicine, California 94305.
R G
RG
Lafrenière
C J
CJ
Brown
V E
VE
Powers
L
L
Carrel
K E
KE
Davies
D F
DF
Barker
H F
HF
Willard
D001483:Base Sequence; D002460:Cell Line; D002503:Centromere; D002869:Chromosome Aberrations / Q000235:genetics; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D015342:DNA Probes; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D014407:Tumor Cells, Cultured; D014960:X Chromosome
D015342:DNA Probes; D005819:Genetic Markers