Treatment of neonatal immune thrombocytopenia with high dose intravenous gamma-globulin.
Five term neonates diagnosed with immune thrombocytopenia were treated with 1 g/kg/day intravenous gamma-globulin. Clinical and laboratory evidence of thrombocytopenia resolved completely in 4 of the 5 patients after a single dose. Only 1 patient received a second dose of the drug. This treatment protocol requires less gamma-globulin than other protocols to safely reduce length of hospitalization.
Department of Pediatrics, Hadassah Medical Center, Ein Kerem, Jerusalem, Israel.
N
N
Linder
S C
SC
Shapiro
A M
AM
Moser
J
J
Roitman
D
D
Engelhard
D001327:Autoimmune Diseases / Q000097:blood / Q000628:therapy*; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D007116:Immunization, Passive; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D010976:Platelet Count; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013921:Thrombocytopenia / Q000097:blood / Q000628:therapy*; D005719:gamma-Globulins / Q000008:administration & dosage*
D005719:gamma-Globulins