Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice.
Central antimuscarinic actions of dopamine receptor agonists: N,N-dipropylaminotetrain (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), were evaluated against oxotremorine-induced tremors in mice. Both TL-68 and RDS-127 inhibited the tremor intensity but were less potent than atropine.
Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
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Sahin
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Tuncer
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Ilhan
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D015259:Dopamine Agents / Q000627:therapeutic use*; D007189:Indans / Q000627:therapeutic use*; D007192:Indenes / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000627:therapeutic use*; D010095:Oxotremorine / Q000633:toxicity; D010276:Parasympatholytics; D013764:Tetrahydronaphthalenes / Q000627:therapeutic use*; D014202:Tremor / Q000139:chemically induced / Q000188:drug therapy*
D015259:Dopamine Agents; D007189:Indans; D007192:Indenes; D009281:Naphthalenes; D010276:Parasympatholytics; D013764:Tetrahydronaphthalenes; C016891:N,N-dipropyl-2-aminotetralin; D010095:Oxotremorine; D001285:Atropine; C035604:2-N,N-di-n-propylamino-4,7-dimethoxyindan