Increased angiogenesis in diabetes.
Rats with streptozotocin-induced diabetes mellitus showed a 3.4-4.5 times increased angiogenic response following mast-cell activation in situ as compared with age-matched normal controls. The test tissue used was the mesenteric window, which we have previously exploited as a quantitative angiogenesis assay. In the present study two independent techniques for quantifying the angiogenic response showed essentially the same result. The finding of a pathologically increased angiogenic reaction in the diabetic animals is noteworthy since some of the most harmful complications of diabetes in man relate to proliferative vascular lesions.
Department of Pathology, Gothenburg University, Sahlgren's Hospital, Sweden.
K
K
Norrby
A
A
Jakobsson
M
M
Simonsen
J
J
Sörbo
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D008297:Male; D008407:Mast Cells / Q000502:physiology; D008643:Mesentery / Q000098:blood supply; D009389:Neovascularization, Pathologic; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose