Characterization of the variation between batches of Fast-Flo lactose using low frequency dielectric spectroscopy.
The dielectric response of four batches of lactose has been measured over a frequency range of 10(4) to 10(-2) Hz. The spectra corresponding to three of the batches were identical, while the fourth showed a marked reduction in response. This particular batch has also been reported to exhibit longer disintegration times than the other three when formulated as a tablet. The potential use of dielectric spectroscopy as a means of screening batches of pharmaceutical materials is discussed.
Craig
D Q
DQ
School of Pharmacy, University of London, UK.
Davies
C F
CF
Boyd
J C
JC
Hakes
L B
LB
D002626:Chemistry, Pharmaceutical; D004563:Electrochemistry; D007785:Lactose / Q000737:chemistry*; D010316:Particle Size; D013053:Spectrophotometry; D013607:Tablets
D013607:Tablets; D007785:Lactose