Immune response to intradermally injected inactivated poliovirus vaccine.
Immune response to intradermal inoculation of a fractional dose of inactivated poliovirus vaccine (IPV) was measured in 8 adults and 10 children who were previously immune. A striking 4-fold to 1024-fold antibody booster response to all 3 poliovirus serotypes was found in 15 subjects and a similar response to 2 poliovirus serotypes occurred in the other 3 children. Induration and erythema of 3 mm diameter or above, indicative of a cell-mediated immune response, was seen in 12 subjects. Intradermal inoculation of IPV may be a useful technique for secondary immunisation programmes against polio and its use for primary immunisation merits investigation.
Samuel
B U
BU
Indian Council of Medical Research Centre of Virology, Christian Medical College Hospital, Vellore, Tamilnadu.
Cherian
T
T
Sridharan
G
G
Mukundan
P
P
John
T J
TJ
D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D002648:Child; D006801:Humans; D007111:Immunity, Cellular; D007271:Injections, Intradermal; D008875:Middle Aged; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage / Q000276:immunology*
D000914:Antibodies, Viral; D011054:Poliovirus Vaccine, Inactivated