HIV-2 infection in hospitalized patients in Bissau, Guinea-Bissau.
During 11 months in 1989-1990, 1009 consecutive hospitalized adult patients admitted to the medical wards of the National Hospital in Bissau were interviewed, examined clinically, and tested for antibodies to HIV-1 and HIV-2. The prevalence of HIV-2 infection was 20.4% (206 out of 1009) and of HIV-2-associated AIDS 4.4% (44 out of 1009). HIV-2 infection was more frequent in women (25%, 110 out of 440) than in men (16.9%, 96 out of 569). HIV-1 infection was diagnosed in one patient only, and one patient (with AIDS) had reactivity to both HIV-1 and HIV-2. Among HIV-2-seropositive patients, AIDS was demonstrated in 21.3% and AIDS-related symptoms (not fulfilling the AIDS criteria) in 19.4%. The frequency of AIDS-associated symptoms was significantly higher in HIV-2-seropositive patients than in seronegative patients. The clinical profile of the HIV-2-associated AIDS cases was very similar to that described in HIV-1-associated AIDS cases in Africa. Seven out of 51 patients fulfilling the clinical criteria for AIDS were HIV-seronegative. The World Health Organization (WHO) clinical case definition for AIDS in Africa had a specificity of 99% and a positive predictive value of 86%. Tuberculosis was more common in HIV-2-seropositive patients (6.3%) than in HIV-2-seronegative patients (2.2%). A history of blood transfusion was a significant risk factor for HIV-2 infection. HIV-2 infection and AIDS are public health problems in Guinea-Bissau.
Department of Immunology, National Bacteriological Laboratory, Stockholm, Sweden.
A
A
Nauclér
P
P
Albino
A P
AP
Da Silva
P A
PA
Andreasson
S
S
Andersson
G
G
Biberfeld
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D006800:Deltaretrovirus Infections / Q000453:epidemiology*; D005260:Female; D006169:Guinea-Bissau / Q000453:epidemiology; D015483:HIV Antibodies / Q000032:analysis; D015658:HIV Infections / Q000453:epidemiology; D015528:HIV Seroprevalence; D015497:HIV-1; D015498:HIV-2; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged
D015483:HIV Antibodies