Anorexia following the intrahypothalamic administration of amylin.
The intrahypothalamic injection of rat amylin reduced feeding in schedule-fed rats for eight hours. Specificity of this anorectic response was indicated by an appropriate dose-response relationship and the absence of effect of human amylin. Amylin-induced anorexia was accompanied by alterations in neurotransmitter metabolism similar to those observed in anorectic tumor-bearing rats. These results indicate that amylin may inhibit feeding by acting directly on hypothalamic neurons to alter metabolism of neurotransmitter systems known to affect feeding behavior.
Department of Surgery, University of Cincinnati Medical Center, OH 45267.
W T
WT
Chance
A
A
Balasubramaniam
F S
FS
Zhang
S J
SJ
Wimalawansa
J E
JE
Fischer
D000682:Amyloid / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D000818:Animals; D001067:Appetite Depressants; D001923:Brain Chemistry / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D006801:Humans; D007031:Hypothalamus; D007267:Injections; D058228:Islet Amyloid Polypeptide; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000682:Amyloid; D001067:Appetite Depressants; D058228:Islet Amyloid Polypeptide; D018377:Neurotransmitter Agents; D015740:Calcitonin Gene-Related Peptide