Quinpirole to the accumbens reduces exploratory and amphetamine-elicited locomotion.
Locomotor activity measured in an open-field apparatus was increased by adding partitions to enhance exploratory locomotion and by injecting amphetamine into the nucleus accumbens. Administration of the dopamine D2 agonist, quinpirole, into the nucleus accumbens reduced significantly both exploratory and amphetamine-elicited locomotion. It is suggested that these effects of quinpirole are mediated by different presynaptic mechanisms.
Department of Physiology, University of Western Ontario, London, Canada.
G J
GJ
Mogenson
M
M
Wu
D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology; D004873:Ergolines / Q000008:administration & dosage / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects*; D019257:Quinpirole; D051381:Rats; D011919:Rats, Inbred Strains; D013238:Stereotaxic Techniques
D015259:Dopamine Agents; D004873:Ergolines; D019257:Quinpirole; D000661:Amphetamine