A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Strasbourg, France.
P
P
Basset
J P
JP
Bellocq
C
C
Wolf
I
I
Stoll
P
P
Hutin
J M
JM
Limacher
O L
OL
Podhajcer
M P
MP
Chenard
M C
MC
Rio
P
P
Chambon
D000595:Amino Acid Sequence; D001483:Base Sequence; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004622:Embryo, Mammalian / Q000378:metabolism; D005109:Extracellular Matrix / Q000201:enzymology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D053507:Matrix Metalloproteinase 11; D008666:Metalloendopeptidases / Q000235:genetics*; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000032:analysis; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D006133:Growth Substances; D012313:RNA; D004247:DNA; D053507:Matrix Metalloproteinase 11; D008666:Metalloendopeptidases; D013755:Tetradecanoylphorbol Acetate