HIV-1 in trophoblastic and villous Hofbauer cells, and haematological precursors in eight-week fetuses.
AIDS in children is usually caused by vertical transmission of human immunodeficiency virus type 1 (HIV-1). Aborted eight-week fetal and placental tissue from HIV-1 positive and negative (enzyme-linked immunosorbent assay and Western blot) women was analysed by immunocytochemistry and in-situ hybridisation. Maternal decidual leucocytes, villous trophoblastic derivatives, villous mesenchymal cells, and embryonic blood cell precursors in tissues from seropositive patients all stained for HIV-1 antigen and hybridised for nucleic acids. These observations suggest that a cytological pathway for vertical transmission of HIV-1 is established by eight weeks gestational age.
Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
S H
SH
Lewis
C
C
Reynolds-Kohler
H E
HE
Fox
J A
JA
Nelson
D000328:Adult; D000911:Antibodies, Monoclonal; D002824:Chorionic Villi / Q000032:analysis*; D004730:Endothelium, Vascular / Q000473:pathology; D015672:Erythroid Precursor Cells / Q000032:analysis; D005260:Female; D015488:HIV Antigens / Q000032:analysis*; D015700:HIV Envelope Protein gp41 / Q000032:analysis; D006679:HIV Seropositivity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000032:analysis*; D008264:Macrophages / Q000032:analysis*; D010920:Placenta / Q000032:analysis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D013194:Staining and Labeling; D014327:Trophoblasts / Q000032:analysis*
D000911:Antibodies, Monoclonal; D015488:HIV Antigens; D015700:HIV Envelope Protein gp41