Inhibition of angiogenesis by vitamin D3 analogues.
The effects of vitamin D3 and two analogues on embryonic angiogenesis were studied in 4.5-day-old chick embryo chorioallantoic membranes. The active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3, and a synthetic vitamin D3 analogue, 22-oxa-1 alpha,25-dihydroxyvitamin D3, inhibited angiogenesis in a dose-dependent manner, the inhibition occurring in the picomolar range. In contrast, vitamin D3 was not effective. The results suggest that these two vitamin D3 analogues might be promising anti-angiogenic agents for controlling the angiogenesis which occurs in several pathological conditions, including tumor development.
Division of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Japan.
T
T
Oikawa
K
K
Hirotani
H
H
Ogasawara
T
T
Katayama
O
O
Nakamura
T
T
Iwaguchi
A
A
Hiragun
D000818:Animals; D002117:Calcitriol / Q000031:analogs & derivatives / Q000494:pharmacology; D002642:Chick Embryo; D002762:Cholecalciferol / Q000494:pharmacology*; D009389:Neovascularization, Pathologic
D002762:Cholecalciferol; D002117:Calcitriol; C051883:maxacalcitol