Cell-mediated and humoral immune responses to total hip replacement under spinal or general anaesthesia.
Regional anaesthesia has many advantages over general anaesthesia in hip surgery. When the effects of total hip replacement under spinal or general anaesthesia were compared in 22 patients, the only difference between the groups occurred in PHA-induced lymphocyte proliferative responses. In contrast, no differences between the groups were observed in leucocyte or differential counts, lymphocyte or subtype counts, most mitogen-induced lymphocyte proliferative responses, NK-cell activity, IgG, IgM or IgA production by unstimulated or PWM-stimulated lymphocytes, proliferative responses of control lymphocytes with 15% patient serum, or chemiluminescence values in phagocytosis of zymosan opsonized with patient serum. Thus, regional anaesthesia is indicated in total hip replacement for reasons other than the immune response.
Department of Anaesthesiology, University of Turku, Finland.
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Salo
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Nissilä
D000368:Aged; D000768:Anesthesia, General; D000775:Anesthesia, Spinal; D000917:Antibody Formation; D000939:Epitopes / Q000032:analysis; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000502:physiology; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D007074:Immunoglobulin G; D006854:Hydrocortisone