Glutathione peroxidase deficiency and childhood seizures.
4 children with intractable seizures, repeated infections, and intolerance to anticonvulsants had evidence of glutathione peroxidase deficiency. 2 had low intracellular enzyme activity but normal blood selenium and high plasma glutathione peroxidase concentrations. The other 2 had low intracellular glutathione peroxidase activity with low circulating glutathione peroxidase and selenium concentrations. The clinical state of the children improved after discontinuation of anticonvulsant medication and selenium substitution.
Weber
G F
GF
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
Maertens
P
P
Meng
X Z
XZ
Pippenger
C E
CE
D000927:Anticonvulsants / Q000009:adverse effects; D005979:Glutathione Peroxidase / Q000097:blood / Q000172:deficiency*; D005980:Glutathione Reductase / Q000172:deficiency*; D006801:Humans; D007223:Infant; D007424:Intracellular Fluid / Q000201:enzymology; D008297:Male; D012008:Recurrence; D012640:Seizures / Q000188:drug therapy / Q000201:enzymology*; D012643:Selenium / Q000097:blood / Q000627:therapeutic use
D000927:Anticonvulsants; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D012643:Selenium