Properties and function of lysyl oxidase.
Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed.
Kagan
H M
HM
Department of Biochemistry, Boston University School of Medicine, Massachusetts.
Trackman
P C
PC
D000818:Animals; D003238:Connective Tissue / Q000201:enzymology*; D005109:Extracellular Matrix / Q000201:enzymology*; D006801:Humans; D008171:Lung Diseases / Q000201:enzymology; D008970:Molecular Weight; D008249:Protein-Lysine 6-Oxidase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*
D008249:Protein-Lysine 6-Oxidase