A randomized prospective study to compare ceftizoxime with cephradine as single dose prophylaxis in elective cholecystectomy.
This study compares the efficacy of ceftizoxime with that of cephradine as single agent prophylaxis in elective cholecystectomy. The incidence of purulent wound infection was low in both groups (ceftizoxime 1/99; cephradine 2/92). No adverse reactions to the trial antibiotics occurred in either group. Ceftizoxime is a safe, effective, convenient and well-tolerated antibiotic for use as single agent prophylaxis in elective cholecystectomy. However, because it has no demonstrable advantage over cephradine and is three times as expensive, its routine use is not justified.
University Surgical Unit, Southampton General Hospital.
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D
Skipper
A P
AP
Corder
S J
SJ
Karran
D015296:Ceftizoxime / Q000627:therapeutic use*; D002515:Cephradine / Q000627:therapeutic use*; D002763:Cholecystectomy; D003428:Cross Infection / Q000517:prevention & control*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
D015296:Ceftizoxime; D002515:Cephradine