[The role of proto-oncogenes in fundamental manifestations of life].
Problems of the origin, structure and functions, in the cells and tissues, of the so-called proto-oncogenes (c-onc)--cell genes, homologues and oncogene foreparents (v-onc)--are considered in the review. Up-to-date data are given to show the participation of the main groups of proto-oncogenes in the processes of cell division, proliferation and differentiation. The role of c-onc genes is found to be important for fundamental manifestations of the cell life activity. Special attention is paid to the problem of interrelation of the proto-oncogenes with growth factors and their receptors.
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IF
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002468:Cell Physiological Phenomena; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000235:genetics* / Q000473:pathology; D009856:Oncogene Proteins, Viral / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D016315:Proto-Oncogene Proteins c-abl / Q000502:physiology; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000502:physiology; D011519:Proto-Oncogenes / Q000502:physiology*; D013724:Teratoma / Q000235:genetics / Q000473:pathology; D014407:Tumor Cells, Cultured
D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D016315:Proto-Oncogene Proteins c-abl; D016392:Proto-Oncogene Proteins pp60(c-src)
O roli protoonkogenov v fundamental'nykh proiavleniakh zhizni.