[Histochemical changes in Clonorchis sinensis after pyquiton treatment].
Some histochemical changes in adult C. sinensis collected from rats infected artificially and treated with pyquiton were observed. 1 h after administration the glycogen content showed a slight decrease which became prominent 24h later and almost disappeared at 48h post-medication. There was an increase in protein content in the parenchymal tissues of worms 1h after treatment, especially in the reproductive organ 24h after treatment. RNA content was decreased 1h post administration and continued decreasing gradually so that very little could be seen 48h later. An increase in the activities of SDH, MDH and Ca-ATPase was seen at the beginning and became marked 24h after medication, while that for G-6-PDH was detected 48h after drug administration. No obvious changes in DNA, lipid, AKP, ACP and phenolase were detected within 1-48h after treatment.
Department of Parasitology, China medical University.
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Pang
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Li
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Yu
D000818:Animals; D003003:Clonorchiasis / Q000188:drug therapy / Q000469:parasitology*; D003004:Clonorchis sinensis / Q000187:drug effects / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D006651:Histocytochemistry; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D011223:Praziquantel / Q000627:therapeutic use*; D012313:RNA / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D012313:RNA; D011223:Praziquantel; D006003:Glycogen; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase