[A pharmacological analysis of the anxiolytic activity of uridine].
The effects of prazosin (0.6 and 3 mg/kg), propranolol (5 mg/kg), haloperidol (0.1 and 0.5 mg/kg) and ciproheptaline (0.3 and 0.6 mg/kg) on the anxiolytic (anticonflict) action of a pyrimidine ribonucleoside uridine, a hypothetic endogenic regulator of anxiety states were studied in the experiments on male CBWA mice. It was found that the degree of the anxiolytic effect of uridine decreases at the blockade of alpha 1, beta 2, D2 and H1-receptors and significantly increases at the blockade of 5-HT2-receptors. This suggests the involvement of the mentioned receptors in the processes of realization of uridine anxiolytic activity as well as the presence of the central serotonin-negative component in the mechanisms of action of uridine.
Karkishchenko
N N
NN
Khaĭtin
M I
MI
Simkina
Iu N
IuN
D000818:Animals; D014151:Anti-Anxiety Agents; D001921:Brain / Q000187:drug effects; D003220:Conflict, Psychological; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011600:Psychopharmacology; D011956:Receptors, Cell Surface / Q000187:drug effects; D014529:Uridine / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D011956:Receptors, Cell Surface; D014529:Uridine
Farmakologicheskiĭ analiz anksioliticheskoĭ aktivnosti uridina.