Correlation between trimester of fetal wastage and anti-cardiolipin antibody titer.
The existence of circulating lupus anticoagulant and anti-cardiolipin antibodies (ACA) has been reported to be associated with recurrent fetal loss. We used an enzyme-linked immunosorbent assay (ELISA) for detection of ACA in plasma samples from 104 women with a history of recurrent fetal loss. The normal range of the ACA level was defined as less than 6 GPL (IgG anti-cardiolipin) units (n = 100 normal plasma samples). Nine women (9.7%) were positive for ACA. The population was divided into two groups on the basis of medical history, and analysis revealed that 42.8% (3/7) of the group of patients with at least one fetal loss in the second or third trimester were positive for ACA; their mean ACA titer was 34 GPL units.
Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, Japan.
K
K
Toyoshima
T
T
Makino
T
T
Sugi
S
S
Nozawa
R
R
Iizuka
Y
Y
Ikeda
T
T
Ikeda
D000022:Abortion, Spontaneous / Q000097:blood / Q000276:immunology*; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D002308:Cardiolipins / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood / Q000276:immunology; D011263:Pregnancy Trimester, Third / Q000097:blood / Q000276:immunology; D012008:Recurrence
D000888:Antibodies, Anti-Idiotypic; D002308:Cardiolipins