Effector T lymphocytes present in demyelinating lesions induced by Theiler's virus.
Theiler's virus causes chronic primary demyelination associated with viral persistence in SJL/J mice. We have investigated the effector functions of T lymphocytes isolated from inflammatory brain lesions to detect a local immune dysfunction associated with viral persistence. In vitro, CD4+ T cells induced B-lymphocyte proliferation and antibody secretion; CD8+ T cells had cytolytic activity. Therefore, Theiler's virus persistence does not include local immune unresponsiveness.
Laboratory of Slow Viruses, Pasteur Institute, Paris, France.
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D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003711:Demyelinating Diseases / Q000209:etiology / Q000276:immunology*; D004769:Enterovirus Infections / Q000150:complications / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D004680:Maus Elberfeld virus / Q000276:immunology*; D051379:Mice; D051381:Rats; D013116:Spinal Cord / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology