Improved survival of transplanted cortical brain tissue grafts by iloprost in rats.
The cytoprotective effect of iloprost on the viability and survival of embryonic cortical brain tissue grafts was examined ultrastructurally under light and electron microscopy before and 4 weeks after transplantation surgery. It was shown that neural grafts stored in iloprost solution (50 ng/mL) for 3 hours were more or less in a normal cytoarchitecture compared with saline-preserved grafts. Moreover, it was demonstrated that 4 weeks after transplantation, graft tissues stored in iloprost solution for 3 hours before implantation maintained a successful survival. Thus, a higher cellular population with new vascularization areas and preservation of myelin formation were accepted as a desirable integration of the graft tissue into the host brain tissue. The mechanism of action of iloprost is discussed.
Department of Neurosurgery, School of Medicine, University of Hacettepe, Ankara, Turkey.
S
S
Palaoğlu
A
A
Erbengi
S
S
Kaya
T
T
Erbengi
R K
RK
Türker
D000818:Animals; D001921:Brain / Q000196:embryology / Q000648:ultrastructure; D011464:Epoprostenol / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D016285:Iloprost; D008854:Microscopy, Electron; D009417:Nerve Tissue / Q000196:embryology / Q000637:transplantation* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D011464:Epoprostenol; D016285:Iloprost