Piperacillin compared with cefuroxime plus metronidazole in diffuse peritonitis.
Eighty-five patients were randomly allocated to receive either piperacillin (n = 38) or cefuroxime plus metronidazole (n = 45) after surgical treatment of diffuse peritonitis; 78 were evaluable. A mean of 1.5 (piperacillin group) and 1.7 (cefuroxime/metronidazole group) pathogens/patient were identified. Twenty-seven patients (71%) were successfully treated in the piperacillin group compared with 29 (64%) in the cefuroxime/metronidazole group. These data suggest that piperacillin was neither better nor worse than cefuroxime/metronidazole in diffuse, secondary peritonitis.
University Hospital, Kuopio, Finland.
M
M
Paakkonen
E M
EM
Alhava
R
R
Huttunen
K
K
Karjalainen
J
J
Lahtinen
P
P
Miettinen
H
H
Silvola
J
J
Viitanen
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002444:Cefuroxime / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy*; D010878:Piperacillin / Q000627:therapeutic use*
D008795:Metronidazole; D002444:Cefuroxime; D010878:Piperacillin