[Cytokeratin expression of tumor tissue in cutaneous merkeliomatosis (disseminated cutaneous Merkel cell carcinomas)].
In 2 patients suffering from cutaneous merkeliomatosis, we investigated the immunohistochemical expression of cytokeratin in cutaneous tumors, making use of 3 monoclonal antibodies. We observed a strong selective cytoplasmic fluorescence of the tumor cells in formalin-fixed tissue sections. Thus we were able to detect single intra-epidermal tumor cells. Both these findings and the intracorneal occurrence of tumor cells argue for a transepidermal elimination process. The reactivity patterns with monoclonal anticytokeratins revealed a cytokeratin expression of simple epithelial including cytokeratin 19.
Klinik und Poliklinik für Hautkrankheiten, Bereichs Medizin der Friedrich-Schiller-Universität Jena.
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Wollina
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Karsten
D000911:Antibodies, Monoclonal; D015266:Carcinoma, Merkel Cell / Q000473:pathology*; D003593:Cytoplasm / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006801:Humans; D007633:Keratins / Q000032:analysis*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D007633:Keratins
Zytokeratin-Expression des Tumorgewebes bei kutaner Merkeliomatose (Disseminierte kutane Merkelzell-Karzinome).