Influence of simultaneous supplementation of zinc and copper during chelation of lead in rats.
The influence of zinc and copper supplementation during chelation therapy to reduce zinc and copper imbalance and promote lead elimination from the body, was investigated in rats poisoned with lead. The simultaneous supplementation of zinc and copper increased urinary lead excretion by calcium disodium ethylenediamine tetraacetic acid (CaNa2EDTA) compared to treatment with CaNa2EDTA alone. Combination therapy was effective in potentiating the depletion of blood and renal lead by CaNa2EDTA and meso 2,3-dimercapto succinic acid (DMSA). Combination therapy was also more effective in reducing hepatic lead by CaNa2EDTA and blood lead by 2,3-dimercapto propane sulphonate (DMPS). Zinc and copper supplementation produced a more effective reversal of inhibited blood delta-aminolevulinic acid dehydratase (ALAD) activity, urinary delta-aminolevulinic acid excretion and depleted body zinc and copper status.
Division of Pharmacology and Toxicology, Defence Research & Development Establishment, Gwalior, India.
S J
SJ
Flora
D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use; D015913:Chelation Therapy; D003300:Copper / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D007854:Lead / Q000633:toxicity*; D000623:Porphobilinogen Synthase / Q000097:blood; D011524:Protoporphyrins / Q000097:blood; D051381:Rats; D015032:Zinc / Q000008:administration & dosage / Q000494:pharmacology*
D002614:Chelating Agents; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007854:Lead; D003300:Copper; D000622:Aminolevulinic Acid; D000623:Porphobilinogen Synthase; D015032:Zinc