A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.
A complex of polypeptides derived from a precursor is present on the surface of the malaria merozoite. During erythrocyte invasion only a small fragment from this complex is retained on the parasite surface and carried into the newly infected red cell. Antibodies to this fragment will interrupt invasion.
Blackman
M J
MJ
Division of Parasitology, National Institute for Medical Research, London, United Kingdom.
Heidrich
H G
HG
Donachie
S
S
McBride
J S
JS
Holder
A A
AA
D000818:Animals; D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology* / Q000648:ultrastructure; D006801:Humans; D008288:Malaria / Q000469:parasitology / Q000517:prevention & control; D010446:Peptide Fragments / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology* / Q000648:ultrastructure; D015800:Protozoan Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000939:Epitopes; D010446:Peptide Fragments; D015800:Protozoan Proteins