[Effects of substance P and its fragments on microhemodynamics in animal experiments].
Action of the synthetic substance P (SP1-11) and its modified fragment (MSP1-4) on microhemodynamics was investigated in experiments. Significant hypotensive effect and reduction of blood flow velocity in rat mesenteric microvessels were produced by both substances, no changes of microvessels diameter were observed. Effective concentrations of the SP1-11 and MSP1-4 were revealed, being 10(-6) M and 10(-4) M, respectively. Organ specificity of substance P vascular effects is suggested.
V S
VS
Shinkarenko
E Iu
EIu
Kostromina
Iu
Iu
Odar'iuk
D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009928:Organ Specificity; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*
D010446:Peptide Fragments; D013373:Substance P
Vliianie substantsii P i ee fragmentov na mikrogemodinamiku v éksperimente.