Sequence similarity between opioid peptide precursors and DNA-binding proteins.
The opioid peptide precursors, preprodynorphin and preproenkephalin show structure similarity with a transcription factor, hunchback and the putative helix-loop-helix DNA-binding proteins, lil-1, tal and twist. Segments with similarity contain the three enkephalin sequences in preprodynorphin and one in preproenkephalin which are present within heptapeptide repeats characteristic of an alpha-helical coiled-coil structure distinctive of an amphipathic helix-loop-helix DNA-binding motif. Hunchback and the opioid prohormones also have cystein-rich regions characteristic of zinc-finger domains in common.
Department of Drug Dependence Research, Karolinska Institute, Stockholm, Sweden.
Bakalkin GYa
D
D
Ponomariev
R A
RA
Sarkisyan
L
L
Terenius
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004247:DNA; D004268:DNA-Binding Proteins / Q000235:genetics*; D004399:Dynorphins / Q000235:genetics*; D004745:Enkephalins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D014157:Transcription Factors / Q000235:genetics*
D004268:DNA-Binding Proteins; D004745:Enkephalins; D011498:Protein Precursors; D014157:Transcription Factors; C036448:pre-prodynorphin; D004399:Dynorphins; D004247:DNA; C033660:preproenkephalin