[The removal efficiency of beta 2-microglobulin, alpha 1-microglobulin and alpha 1-acid glycoprotein by using dialyzers in the bloodstream and transference of endotoxin through membranes].
Retention of beta 2-microglobulin (beta 2-MG) has been indicated as one of the causes of hemodialysis-associated amyloidosis. Membranes with higher permeability (high-performance membrane) have recently been developed accordingly. Several dialyzers were tested by us in an attempt to study their removal efficiency of beta 2-MG and higher molecular substances of alpha 1-microglobulin (alpha 1-MG) and alpha 1-acid glycoprotein (alpha 1-AG), as well as transferring of endotoxin (ET) through membranes into bloodstream. The membranes subjected to our study were PMMA, CTA, PS, EVAL-C and CA. Removal efficiency of beta 2-MG through EVAL-C and CA was lower as compared with that through other membranes (P less than 0.05), while the EVAL-C showed relatively higher removal efficiency for alpha 1-MG and alpha 1-AG. Permeability for ET was not observed with all membranes studied herein.
Ueyama Hospital, Kagoshima.
S
S
Ueyama
S
S
Kiyomizu
K
K
Endo
N
N
Nagayama
K
K
Oda
T
T
Ohashi
W
W
Yamashita
R
R
Harada
T
T
Arima
D000510:Alpha-Globulins / Q000302:isolation & purification*; D004731:Endotoxins / Q000097:blood*; D005069:Evaluation Studies as Topic; D006801:Humans; D008567:Membranes, Artificial; D009961:Orosomucoid / Q000302:isolation & purification*; D006435:Renal Dialysis / Q000295:instrumentation*; D001613:beta 2-Microglobulin / Q000302:isolation & purification*
D000510:Alpha-Globulins; D004731:Endotoxins; D008567:Membranes, Artificial; D009961:Orosomucoid; C016001:alpha-1-microglobulin; D001613:beta 2-Microglobulin