Low-dose aspirin and vascular response in pregnant patients sensitive to angiotensin II.
The angiotensin sensitivity test was performed in 25 high risk pregnant women before and after administration of low-dose aspirin (100 mg/day for 7 days). After aspirin administration there was a significant decrease in AII sensitivity in sensitive patients with no change in nonsensitive patients. Low-dose aspirin favorably affects sensitivity to AII in sensitive patients, thus indicating a reduced vascular reactivity as a consequence of this regimen.
Department of Obstetrics and Gynaecology, Catholic University, Rome, Italy.
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A
Caruso
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Ferrazzani
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De Carolis
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A
Lanzone
S
S
Mancuso
D000804:Angiotensin II; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*
D000804:Angiotensin II; D001241:Aspirin