XbaI-RFLP of the APOB gene in a sample group from southern Italy.
The XbaI Restriction Fragment Length Polymorphism (RFLP) of the APOB gene at codon 2488 was investigated in a sample group from Southern Italy (165 subjects), taken from a population characterized by a low average level of cholesterolemia. The X2 allele (presence of XbaI cutting site), that in several groups was found to be associated with increased cholesterolemia, showed in Southern Italians a frequency of 39% which is significantly (P much less than 0.001) lower than that found in the majority of the Caucasoid groups so far tested (50%). However, an analysis of both cholesterol and APOB serum levels performed in a sample of 82 subjects, homogeneous for sex and age did not reveal any significant association between lipidemic parameters and APOB-XbaI genotypes.
Cell Biology Department, University of Calabria, Rende CS, Italy.
G
G
De Benedictis
G
G
Rose
O
O
Leone
G
G
Passarino
R L
RL
Mazzei
L
L
Crescibene
C
C
Brancati
D000483:Alleles; D015139:Blotting, Southern; D002784:Cholesterol / Q000097:blood*; D004247:DNA / Q000235:genetics; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
D004247:DNA; D002784:Cholesterol