Unusual solubility behaviour of cyclosporin A in aqueous media.
The solubility of cyclosporin A was determined in water and in Sorensen buffers at pH 1.2 and 6.6 at temperatures ranging from 5 to 37 degrees C. No differences in solubility behaviour were observed among the three aqueous media. Solubility was found to be inversely proportional to the temperature in each medium, indicating that the heat of solution was exothermic in each case.
Department of Pharmacy, University of Athens, Greece.
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G
Ismailos
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C
Reppas
J B
JB
Dressman
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P
Macheras
D003524:Cyclosporins / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D014867:Water
D003524:Cyclosporins; D014867:Water