Immune system-associated antigens on the surface of peripheral blood lymphocytes in patients with Alzheimer's disease.
We investigated the immune-associated antigens of peripheral lymphocytes from 13 patients with Alzheimer's disease (AD) and 13 age-matched healthy control subjects using two-color analysis with flow cytometry. Four ratios of immune-related antigens, T/B lymphocytes, CD4/CD8, CD4/CD45R and CD4/HLA-DR, were compared for the AD and control groups. The T/B and CD4/CD8 ratios did not differ between the groups, the ratio of CD4+CD45R+ subset in the AD group was lower than the ratio in the control group, and the ratios of CD4+ CD45R- and CD4+HLA-DR+ subsets in the AD group were significantly higher. Further, in the AD group, the CD4+ CD45R+/CD4+ ratio was lower and the CD4+ CD45R- CD4+ ratio was higher than in the control group.
Ikeda
T
T
Department of Neuropsychiatry, Yamaguchi University School of Medicine, Kogushi, Ube, Japan.
Yamamoto
K
K
Takahashi
K
K
Yamada
M
M
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology*; D015703:Antigens, CD / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D017493:Leukocyte Common Antigens; D007958:Leukocyte Count; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015703:Antigens, CD; D015704:CD4 Antigens; D006684:HLA-DR Antigens; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens