Failure of dopexamine to protect the hypoxemic newborn rabbit kidney.
The renal effects of dopexamine, a new dopaminergic agonist devoid of any alpha-adrenergic effect, were studied in 11 anesthetized newborn rabbits undergoing an acute hypoxemic normocapnic stress. Acute hypoxemia (PaO2 = 41 mm Hg) was associated with a marked increase in renal vascular resistance and a consequent decrease in glomerular filtration rate and renal blood flow. These changes were not modified by the administration of dopexamine at 10 micrograms/kg/min. Failure of dopexamine to blunt the hypoxemia-induced vaso-constriction suggests vascular dopaminergic receptor immaturity.
Service de Pédiatrie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
T
T
Jaton
M
M
Thonney
J P
JP
Guignard
D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015259:Dopamine Agents / Q000494:pharmacology*; D000860:Hypoxia / Q000188:drug therapy / Q000503:physiopathology*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000517:prevention & control*; D010100:Oxygen / Q000502:physiology; D010313:Partial Pressure; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D015259:Dopamine Agents; C046318:dopexamine; D010100:Oxygen; D004298:Dopamine