[Treatment with clonidine in a case of the short bowel syndrome with therapy-refractory diarrhea].
A patient with refractory diarrhoea (up to 10 l/d) following colectomy and ileostomy was treated with clonidine, after loperamide, tinctura opii, cholestyramine and somatostatin had failed to reduce stool volume to less than 6 l/d. Under combined treatment with clonidine (1200 micrograms/d) and somatostatin (6 mg/d), which was well tolerated, stool weights were normalised within 24 hours. This case report on the successful anti-diarrhoeic effect of clonidine is completed by experimental data from rat jejunal and duodenal segments. In the presence of the adenylate cyclase-stimulating agent forskolin, clonidine normalised both mucosal cAMP content and cAMP-induced hypersecretion in rat intestine. This suggests that the anti-diarrhoeic effect of clonidine in-vitro results from an alpha 2-receptor mediated inhibition of the stimulated adenylate cyclase. Case report and experimental data therefore support the theory that therapeutical application of clonidine in diarrhoea may be successful.
Scholz
J
J
Abteilung für Anästhesiologie, Universitäts-Krankenhaus Eppendorf, Hamburg.
Bause
H
H
Reymann
A
A
Dürig
M
M
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D003000:Clonidine / Q000494:pharmacology / Q000627:therapeutic use*; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects; D012778:Short Bowel Syndrome / Q000150:complications*; D013004:Somatostatin / Q000627:therapeutic use
D000067956:Adenylyl Cyclase Inhibitors; D011942:Receptors, Adrenergic, alpha; D013004:Somatostatin; D003000:Clonidine
Zur Behandlung mit Clonidin bei kurzdarmsyndrombedingter therapierefraktärer Diarrhö.