Interaction of human alpha fetoprotein with bilirubin.
Human alpha fetoprotein (AFP) binds bilirubin with an affinity somewhat lower than albumin. Free bilirubin was found to have an extinction maximum at 440 nm with an extinction coefficient of 4.97 x 10(4) M-1cm-1. AFP binding with the bile pigment elicits a blue shift while albumin interaction produced red spectral shift.
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
V
V
Bansal
K
K
Kumari
A
A
Dixit
M K
MK
Sahib
D001663:Bilirubin / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D000509:alpha-Fetoproteins / Q000378:metabolism*
D000509:alpha-Fetoproteins; D001663:Bilirubin