Expression of c-myc protein in skin and synovium in psoriasis and psoriatic arthritis.
Monoclonal antibody against c-myc protein was used in the avidin-biotin-peroxidase complex procedure to examine frozen sections of psoriatic and normal skin and psoriatic synovium for the presence of c-myc protein. A significantly greater percentage (88%) of epithelial cells from psoriatic skin lesions stained for c-myc than uninvolved skin (62%) from both psoriatics and normals (p less than 0.001). The intensity of the stain appeared weaker in normal skin specimens. Greater than 95% of psoriatic hyperplastic synovial lining cells stained strongly for c-myc. In all cases, the c-myc staining was confined to the nuclei with no evidence of cytoplasmic staining.
Division of Clinical Immunology, Royal Victoria Hospital, McGill University School of Medicine, Montreal, Quebec, Canada.
C K
CK
Osterland
R D
RD
Wilkinson
E A
EA
St Louis
D015535:Arthritis, Psoriatic / Q000378:metabolism*; D006801:Humans; D007158:Immunologic Techniques; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc; D011519:Proto-Oncogenes; D011565:Psoriasis / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D013194:Staining and Labeling; D013583:Synovial Membrane / Q000378:metabolism*
D011518:Proto-Oncogene Proteins; D016271:Proto-Oncogene Proteins c-myc