[The surface antigens of Rickettsia prowazekii studied with monoclonal antibodies].
R. prowazekii antigens have been tested with the use of monoclonal antibodies (McAb) to different epitopes of the microorganism. As revealed in these tests, McAb B4/4 and A-3/D, active against species-specific thermolabile antigen, interact with protein having a molecular weight of 90-120 KD. McAb C5/2, active against thermostable group antigen common with that of Rickettsia typhi, interact with LPS-like antigen having a molecular weight of 30 KD. Ultrastructural immunochemical studies have revealed that both R. prowazekii antigens are located on surface structures of rickettsiae, such as the microcapsule and cell wall.
Nedialkov
Iu A
IuA
Spitsyn
S V
SV
Drobyshevskaia
E I
EI
Gosteva
V V
VV
Klitsunova
N V
NV
Smirnova
N S
NS
Tarasevich
I V
IV
Nesterenko
V G
VG
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis; D003381:Coxiella / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D007158:Immunologic Techniques; D008854:Microscopy, Electron; D008970:Molecular Weight; D012283:Rickettsia prowazekii / Q000276:immunology* / Q000648:ultrastructure; D012286:Rickettsia typhi / Q000276:immunology; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D000939:Epitopes
Izuchenie poverkhnostnykh antigenov Rickettsia prowazekii pri pomoshchi monoklonal'nykh antitel.