Adverse haemodynamic effects of high-dose aprotinin in a paediatric cardiac surgical patient.
High-dose aprotinin for reduction of intra- and postoperative blood loss was associated with profound hypotension and flushing in a 3.5-year-old child who underwent cardiac surgery. Treatment with noradrenaline and intravenous fluid was required. Cardiovascular stability was restored after 10 minutes.
Department of Anaesthesia, University of Heidelberg, West Germany.
H
H
Böhrer
A
A
Bach
F
F
Fleischer
J
J
Lang
D007611:Aprotinin / Q000008:administration & dosage / Q000009:adverse effects*; D006348:Cardiac Surgical Procedures; D002675:Child, Preschool; D005440:Fluid Therapy; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D009638:Norepinephrine / Q000627:therapeutic use
D007611:Aprotinin; D009638:Norepinephrine