Ion trap tandem mass spectrometric evidence for the metabolism of 3,4-(methylenedioxy)methamphetamine to the potent neurotoxins 2,4,5-trihydroxymethamphetamine and 2,4,5-trihydroxyamphetamine.
Lim
H K
HK
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112.
Foltz
R L
RL
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D000662:Amphetamines / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D009420:Nervous System / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000662:Amphetamines; C074078:2,4,5-trihydroxymethamphetamine; C074079:2,4,5-trihydroxyamphetamine; D008694:Methamphetamine; D015104:3,4-Methylenedioxyamphetamine; D003577:Cytochrome P-450 Enzyme System; D018817:N-Methyl-3,4-methylenedioxyamphetamine