HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.
M A
MA
Kennedy
R
R
Gonzalez-Sarmiento
U R
UR
Kees
F
F
Lampert
N
N
Dear
T
T
Boehm
T H
TH
Rabbitts
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10; D002897:Chromosomes, Human, Pair 7; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000235:genetics; D005801:Genes, Homeobox; D018398:Homeodomain Proteins; D006801:Humans; D007438:Introns; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D015513:Oncogene Proteins / Q000235:genetics*; D009857:Oncogenes; D011518:Proto-Oncogene Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013601:T-Lymphocytes / Q000502:physiology*; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; C487378:Tlx1 protein, mouse; C071250:TLX1 protein, human