[Tyrosine hydroxylase activity in two-dimensional monomolecular films].
The activity of a neurospecific enzyme of tyrosine hydroxylase (TH) in monomolecular films formed onto solid surface was studied. The data obtained show that the formation of two-dimensional films onto negative-charge surfaces by the Langmuir-Schafer technology does not lead to the inactivation of the enzyme. Neuroleptic trifluoperazine increased the activity of TH. Monomolecular films of TH may be used as a sensitive element of biosensors for primary monitoring of neuroleptic-like compounds.
Eremenko
A V
AV
Mineeva
M F
MF
Kurochkin
I N
IN
Chernov
S F
SF
Kuznetsova
E A
EA
Val'dman
A V
AV
D000818:Animals; D015374:Biosensing Techniques; D007031:Hypothalamus / Q000201:enzymology*; D051381:Rats; D014268:Trifluoperazine / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis*
D014268:Trifluoperazine; D014446:Tyrosine 3-Monooxygenase
Aktivnost' tirozingidroksilazy v dvukhmernykh monomolekuliarnykh plenkakh.