Differential expression of class I major histocompatibility complex determinants by lymphoblastic leukemia-lymphoma cell lines.
Two T-cell lines (XR11-4T and XR11-5T), established from radiation-induced, murine lymphoblastic lymphomas, were examined for the expression of class I major histocompatibility complex antigen and tumor induction. These cell lines expressed class I private determinants, H-2.9 and H-2.26, but not the monomorphic determinant defined by monoclonal antibody M1/42. Both cell lines produced tumors in syngeneic and allogeneic hosts. The monomorphic determinant could be demonstrated on both cell lines following growth in allogeneic (BALB/c mice) but not in syngeneic (RFM mice) hosts. The re-expressed determinant present on cells following growth in allogeneic mice was not of host origin. Thus, tumorigenic x irradiation may differentially affect the expression of class I major histocompatibility complex determinants.
Hester
R B
RB
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688.
Rohrer
S D
SD
Liu
P I
PI
Coggin
J H
JH
D000818:Animals; D000939:Epitopes / Q000276:immunology*; D005805:Genes, MHC Class I / Q000276:immunology*; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007953:Leukemia, Radiation-Induced / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D014181:Transplantation Immunology; D014407:Tumor Cells, Cultured / Q000276:immunology
D000939:Epitopes