Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.
A 66-year-old pseudophakic man with primary open-angle glaucoma and ocular cicatricial pemphigoid underwent trabeculectomy and was given postoperative subconjunctival 5-fluorouracil. He developed an inferior corneal epithelial defect and, later, a well-demarcated area of inferior corneal keratinization. Since the corneal keratinization clinically improved with conservative management, surgical intervention was not required.
W.K. Kellogg Eye Center, Department of Ophthalmology, University of Michigan, Ann Arbor 48105-7594.
M J
MJ
Phelan
G L
GL
Skuta
D000368:Aged; D003228:Conjunctiva / Q000378:metabolism; D003316:Corneal Diseases / Q000188:drug therapy / Q000209:etiology*; D005472:Fluorouracil / Q000009:adverse effects*; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007633:Keratins; D008297:Male; D009824:Ointments / Q000627:therapeutic use; D010390:Pemphigoid, Benign Mucous Membrane / Q000150:complications / Q000175:diagnosis; D012086:Reoperation; D014130:Trabeculectomy / Q000009:adverse effects*
D009824:Ointments; D007633:Keratins; D005472:Fluorouracil