Biology of the fibroblast growth factor gene family.
The biology of the fibroblast growth factor (FGF) gene family is reviewed. The structure, expression and known and putative functions of the seven members of this family characterized to date are discussed. These genes include: acidic and basic FGF, the INT.2 and HST proto-oncogenes and the recently characterized FGF.5, FGF.6 and KGF genes. These genes play a role in various processes such as cell proliferation, angiogenesis and embryogenesis, and possibly carcinogenesis.
Institute of Pathology, Soroka Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
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Benharroch
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Birnbaum
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics; D005346:Fibroblast Growth Factors / Q000235:genetics* / Q000502:physiology; D015870:Gene Expression / Q000502:physiology; D006801:Humans; D005810:Multigene Family; D009389:Neovascularization, Pathologic; D009857:Oncogenes / Q000502:physiology; D014945:Wound Healing / Q000235:genetics
D005346:Fibroblast Growth Factors