One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults.
An account is given of the 6- to 12-month survival, and causes of failure in 110 consecutive patients who underwent primary liver transplantation under treatment from the outset with FK 506 and steroids. The patient survival is 92.7%, and the first graft survival is 87.3%. At a very high frequency, the patients achieved good graft function, and they had a relatively low morbidity that was partially ascribable to minimal use and early discontinuance (in 60% of cases) of steroids. Renal dysfunction and other adverse findings were largely confined to patients with poor initial graft function and consequent apparent alteration of the kinetics of FK 506 elimination, causing functional overdosage. Results compare very favorably with our past record using conventional immunosuppression, and support the belief that FK 506 is a superior immunosuppressive agent which is suitable for chronic administration.
Department of Surgery, University of Pittsburgh, PA.
S
S
Todo
J J
JJ
Fung
A
A
Tzakis
A J
AJ
Demetris
A
A
Jain
M
M
Alessiani
S
S
Takaya
R
R
Day
R
R
Gordon
T E
TE
Starzl
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001806:Blood Urea Nitrogen; D002423:Cause of Death; D002784:Cholesterol / Q000097:blood; D003401:Creatine / Q000097:blood; D003524:Cyclosporins / Q000627:therapeutic use; D006085:Graft Survival; D006801:Humans; D006973:Hypertension / Q000150:complications; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007565:Jaundice / Q000150:complications; D007668:Kidney / Q000502:physiology; D016031:Liver Transplantation / Q000379:methods*; D011241:Prednisone / Q000008:administration & dosage; D016019:Survival Analysis; D016559:Tacrolimus; D014527:Uric Acid / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D000900:Anti-Bacterial Agents; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D014527:Uric Acid; D002784:Cholesterol; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003401:Creatine; D001663:Bilirubin; D011241:Prednisone; D016559:Tacrolimus