Effects of short-term administration of human chorionic gonadotropin on immune functions in cryptorchid children.
To delineate the effects of human chorionic gonadotropin (hCG) administration on immune responsiveness, immunological parameters including serum immunoglobulins, total and differential white blood cell count T and B lymphocyte membrane phenotype, in vitro, proliferative response to phytohaemagglutinin, Concanavalin A (ConA) and pokeweed mitogen were studied in 13 prepubertal cryptorchid boys before, during, and 3 months after hCG therapy. Before treatment, all the immunological parameters were normal except for an unexpected high percentage of T suppressor-cytotoxic cells (CD8+). During therapy, the absolute number of total peripheral blood lymphocytes, and that of total T-cells, T helper-inducer cells and of CD8+ subsets were diminished. The percentage of CD8+ cells and lymphocyte response to ConA decreased significantly and returned to normal after hCG withdrawal. The possible effects of long-term hCG treatment remain to be determined.
Department of Paediatrics, University of Pavia, IRCCS Policlinico S. Matteo, Italy.
M
M
Maghnie
A
A
Valtorta
A
A
Moretta
D
D
Larizza
M A
MA
Girani
F
F
Severi
D002648:Child; D006063:Chorionic Gonadotropin / Q000009:adverse effects*; D003208:Concanavalin A / Q000494:pharmacology; D003456:Cryptorchidism / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D016176:T-Lymphocyte Subsets; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
D006063:Chorionic Gonadotropin; D007136:Immunoglobulins; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A