Serum immunoreactive pancreatic phospholipase A2 in patients with various malignant tumors.
The high incidence (40.6%) of elevated serum pancreatic phospholipase A2 (PLA2) was demonstrated in patients with various malignancies. Serum PLA2 was significantly increased in cancer patients compared with healthy sex- and age-matched blood donors (358.4 +/- 168.0 vs. 241.7 +/- 69.0 ng/dl; p less than 0.01). No correlation was observed between serum PLA2 and carcinoembryonic antigen (CEA) in these patients. Although patients with advanced and distantly metastatic cancer of the liver, gallbladder and pancreas showed higher PLA2 levels in serum than those with early cancer, patients with other cancers showed no correlation between serum PLA2 and clinical stage. A combined assay of PLA2 and CEA increased the sensitivity of detection of cancers to 60.8%.
Second Department of Surgery, Osaka University Medical School, Japan.
Y
Y
Oka
M
M
Ogawa
Y
Y
Matsuda
A
A
Murata
J
J
Nishijima
K
K
Miyauchi
K
K
Uda
T
T
Yasuda
T
T
Mori
D000681:Amylases / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000201:enzymology* / Q000601:surgery; D010179:Pancreas / Q000201:enzymology*; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011184:Postoperative Period; D011863:Radioimmunoassay; D012016:Reference Values; D014361:Trypsin Inhibitors / Q000097:blood
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D006242:Haptoglobins; D014361:Trypsin Inhibitors; D002097:C-Reactive Protein; D002570:Ceruloplasmin; D010741:Phospholipases A; D054467:Phospholipases A2; D000681:Amylases