[Significance of disorders of the processes of lipid peroxidation in patients with persistent paranoid schizophrenia resistant to the treatment].
Lipid peroxidation (LPO) processes and the status of the ++bio-antioxidant defence system were studied in 133 male patients with continuous paranoid schizophrenia associated with hallucinatory and paranoid symptomatology, refractory to treatment. According to the ++clinico-pathogenetic principle, 3 groups of resistant patients were made up: an "endogenous" one (because of high progression), a "pharmacogenous" one (secondary, formed in accordance with the mechanisms of "adaptation" to neuroleptics, and a "resistant" one formed on the "pathological ground". The data were compared both to the normal patients (control) and to those in patients with acute paranoid schizophrenia and in a state of a remission. All the examined patients showed activation of LPO while the patients with acute schizophrenia were marked by a dramatic increase (by 2.5 to 3 times) of the intensity of LPO as compared to normals. During formation of therapeutic resistance, all the groups, in addition to the high values of the LPO intensity, demonstrated remarkable signs of depletion of the ++bio-antioxidant defence system, particularly in the group with resistance on the "pathological ground".
Govorin
N V
NV
Govorin
A V
AV
Skazhutin
S A
SA
D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D004351:Drug Resistance / Q000502:physiology; D005979:Glutathione Peroxidase / Q000172:deficiency / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012563:Schizophrenia, Paranoid / Q000188:drug therapy / Q000378:metabolism*
D014150:Antipsychotic Agents; D005979:Glutathione Peroxidase
Znachenie narusheniĭ protsessov perekisnogo okisleniia lipidov u bol'nykh nepreryvnoĭ paranoidnoĭ shizofrenieĭ s terapevticheskoĭ rezistentnost'iu.