Linkage disequilibrium between the HLA-DQA2 alleles and the HLA/DR/DQ complex.
A statistically significant association was observed between alleles of the HLA-DQA2 and of the DR/DQ complex in a DNA-restriction fragment length polymorphism study of 219 members from 21 multiplex families of patients with hyperthyroid Graves' disease and 773 unrelated individuals selected for homozygosity of the HLA-DQA2 alleles. This data provides evidence for linkage disequilibrium rather than for a hot spot of recombination within the HLA-DQ subregion.
Department of Medicine, King's College School of Medicine and Dentistry, London, United Kingdom.
S
S
Ratanachaiyavong
J L
JL
Bidwell
E A
EA
Bidwell
A M
AM
McGregor
D000483:Alleles; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D012150:Polymorphism, Restriction Fragment Length
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens