Disseminated syringomas of the upper extremities. Case history and immunohistochemical and ultrastructural study.
A case of disseminated syringomas with unusual distribution and high age of onset is reported. The 66-year-old male patient presented with multiple lesions confined to dorsum of both hands and flexor side of both forearms. Morphological and immunohistochemical studies using keratin, S-100, carcinoembryonic antigen, and epithelial membrane antigen antibodies were performed both at light microscopical and ultrastructural level. These investigations revealed the presence of keratin filament containing colloid bodies near syringomatous epithelia. Reactivity for carcinoembryonic antigen could be demonstrated on the membranes of intracytoplasmic vesicles as well as within luminal debris. Absence of S-100 and epithelial membrane antigen in the tumor and ultrastructural features indicate ductal origin of syringoma.
2nd Department of Dermatology, University of Vienna, Austria.
D
D
Metze
W
W
Jurecka
W
W
Gebhart
D006607:Adenoma, Sweat Gland / Q000032:analysis* / Q000648:ultrastructure; D000367:Age Factors; D000368:Aged; D001132:Arm; D002272:Carcinoembryonic Antigen / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D011498:Protein Precursors / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012867:Skin / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000032:analysis* / Q000648:ultrastructure
D002272:Carcinoembryonic Antigen; D011498:Protein Precursors; D009418:S100 Proteins; C004818:prekeratin; D007633:Keratins