[The inhibitory effect of oxatomide on oxygen radical products from human eosinophils and an eosinophilic cell line].
Recently, much attention has been paid to the role played by the allergic inflammatory reaction in the role of asthma. Eosinophils are considered to be major inflammatory cells in bronchial asthma. Therefore, in this study, eosinophil-mediated oxygen radicals were examined by means of luminol-dependent chemiluminescence. Also, the effect of oxatomide, an anti-allergic agent, which has an inhibitory effect on eosinophil-mediated natural cytotoxicity against bronchial epithelial cells, on the production of oxygen radicals from eosinophils was studied. The results revealed the inhibitory effects of oxatomide on eosinophil-mediated oxygen radicals products. Furthermore, the inhibitory effect of this agent on oxygen radical products from eosinophilic cell-line named EoL-3, which has been established recently, was observed. We concluded from these results that oxatomide not only has anti-allergic activity but also anti-inflammatory properties for eosinophils.
Fourth Department of Internal Medicine, Kinki University School of Medicine.
J
J
Chihara
A
A
Yasukawa
T
T
Yamamoto
D
D
Kurachi
R
R
Haraguchi
T
T
Mori
M
M
Seguchi
H
H
Uenishi
S
S
Nakajima
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002460:Cell Line; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D003864:Depression, Chemical; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism*; D005609:Free Radicals; D006634:Histamine H1 Antagonists; D006801:Humans; D010100:Oxygen / Q000378:metabolism*; D010879:Piperazines / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005609:Free Radicals; D006634:Histamine H1 Antagonists; D010879:Piperazines; C015408:oxatomide; D010100:Oxygen