[Intravenous immunoglobulins in newborn infants at risk of infection. Comparative efficacy of preparations 7S and 5S].
Some reports have been published concerning the positive effects of using intravenous immunoglobulins as immunotherapy and immunoprophylaxis of infection in newborns. The safety and efficacy of intravenously administered gamma globulins 7S versus 5S was evaluated in 64 high-risk neonates. The infants admitted to this study conformed to the following criteria: birth weight less than 1800 g and gestational age less than 34 weeks; receiving intensive care. The infants were classified into two groups: one group received IgG 7S and the other IgG 5S. The incidence of infection and the mortality rate were assessed in each group. The data show that intravenous immunoglobulin infusions of both IgG 7S and IgG 5S are both safe and effective for the prophylaxis and therapy of infection in high-risk newborns.
Divisione di Neonatologia e Terapia Intensiva Neonatale, Ospedale S. Antonio Abate, Trapani.
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Bonanno Conti
D005069:Evaluation Studies as Topic; D006801:Humans; D007116:Immunization, Passive; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D017053:Infection Control; D007239:Infections / Q000628:therapy; D007275:Injections, Intravenous; D011897:Random Allocation; D012306:Risk; D005719:gamma-Globulins / Q000008:administration & dosage
D005719:gamma-Globulins
Immunoglobuline intravenose in neonati a rischio settico. Efficacia comparativa di preparazioni 7S e 5S.