[Substance P--results of observing the course of plasma levels during heart surgery].
Observing substance P plasma level changes, we examined the adaptation capacities of the human organism in hypothermia during cardiosurgical operations. It was our aim to observe stress-induced changes of substance P concentrations and to find ways of using them as indicators of good or bad adaptation capacity. Plasma level controls were made on 40 cardiosurgical patients. In all cases the substance P concentration varied in correlation to operation-induced periods of stress. There was a clear tendency for all patients to react similarly, although some individual deviations were found, too. Obviously stress provokes a consumption of substance P in plasma which is expressed in decreasing concentrations. Its rapid increase, however, indicates a good adaptation capacity. Since the need for an exogenous substance P substitution was not recognizable at the beginning of the operation, at present only the possibility of prophylactic substitution is given.
Klinik für Anästhesiologie und Intensivtherapie, Humboldt-Universität zu Berlin.
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D000222:Adaptation, Physiological / Q000502:physiology*; D006348:Cardiac Surgical Procedures / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology*; D013373:Substance P / Q000097:blood*
D013373:Substance P
Substanz P--Ergebnisse der Verlaufsbeobachtung der Plasmaspiegelkonzentrationen bei kardiochirurgischen Eingriffen.