Coexpression of cytokeratins, involucrin, and blood group antigens in oral squamous cell carcinomas.
The well and poorly differentiated oral squamous carcinomas preferentially express proteins, blood group antigens, and contain associated dendritic Langerhans' cells. Keratin pearls in well-differentiated carcinomas simulate the differentiation pathway of the normal oral squamous epithelium, whereas poorly differentiated carcinomas do not and appear more heterogeneous. Terminally keratinized cells correlate with involucrin and expression of blood group antigens in keratin pearls, a feature that differs from the nonkeratinizing normal epithelium in which such carcinomas arise. Dendritic Langerhans' cells are reduced in number in squamous carcinomas.
Loyola University, Chicago School of Dentistry, Maywood, Ill.
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D000017:ABO Blood-Group System; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000032:analysis* / Q000473:pathology; D003713:Dendritic Cells / Q000473:pathology; D005353:Fibronectins / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007633:Keratins / Q000032:analysis*; D007797:Laminin / Q000032:analysis; D007801:Langerhans Cells / Q000473:pathology; D009062:Mouth Neoplasms / Q000032:analysis* / Q000473:pathology; D011498:Protein Precursors / Q000032:analysis*; D009418:S100 Proteins / Q000032:analysis; D001613:beta 2-Microglobulin / Q000032:analysis
D000017:ABO Blood-Group System; D002272:Carcinoembryonic Antigen; D005353:Fibronectins; D006680:HLA Antigens; D007797:Laminin; D011498:Protein Precursors; D009418:S100 Proteins; D001613:beta 2-Microglobulin; C032253:involucrin; D007633:Keratins