The effect of aluminium on the heam biosynthesis (in vitro) in bone marrow cells in rats.
The study has been carried out on male Wistar rats. The aim of the present study was to trace the effect of aluminium chloride and aluminium nitrate at concentration 10 microM and 20 microM on haem biosynthesis in vitro in bone marrow cell culture. The ability of haem biosynthesis in bone marrow cell culture after 48 h of experiments with aluminium chloride and aluminium nitrate significantly decreased in relation with the control value.
Laboratory of Animal Haematology and Toxicology, Jagiellonian University, Kraków, Poland.
K
K
Zaman
Z
Z
Dabrowski
H
H
Miszta
O
O
Smoleński
D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D002712:Chlorides / Q000494:pharmacology; D006418:Heme / Q000096:biosynthesis*; D008297:Male; D009566:Nitrates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D017607:Aluminum Compounds; D002712:Chlorides; D009566:Nitrates; D000077410:Aluminum Chloride; D006418:Heme; D000535:Aluminum; C050609:aluminum nitrate