Acute effects of anticonvulsants on brain-stem auditory evoked potentials in rats.
Acute effects of various anticonvulsants on brain-stem auditory evoked potentials (BAEPs) in rats were tested. A high dose of phenytoin abolished all BAEP waves. Carbamazepine increased all 4 wave latencies. Phenobarbital and clonazepam increased the latencies of waves IV and III. Therefore, if BAEPs are to be used as an ancillary test for brain death, the possibility of significant effects of high dosages of anticonvulsants on BAEPs must be considered.
Department of Neurology, Kanazawa Medical University, Kahoku-gun, Japan.
G
G
Hirose
T
T
Chujo
S
S
Kataoka
J
J
Kawada
A
A
Yoshioka
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000097:blood / Q000494:pharmacology*; D001933:Brain Stem / Q000187:drug effects; D002220:Carbamazepine / Q000097:blood / Q000494:pharmacology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D008297:Male; D010672:Phenytoin / Q000097:blood / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects
D000927:Anticonvulsants; D002220:Carbamazepine; D010672:Phenytoin