Probable interaction of sodium divalproex with benzodiazepines.
1. After drug discontinuation and 1 week placebo washout, 12 patients with panic disorders received, for 6 weeks, either placebo or sodium divalproex. During 6 consecutive weeks, alternate medication was given. 2. Severity of panic and anxiety attacks was improved only in patients receiving sodium divalproex as a first medication. 3. Protracted benzodiazepine effects may occur in the dichotomous antipanic activity of sodium divalproex.
Research Department, Louis-H Lafontaine Hospital, Université de Montréal, Canada.
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Lum
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Fontaine
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Elie
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Ontiveros
D000328:Adult; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy* / Q000523:psychology; D001569:Benzodiazepines; D004311:Double-Blind Method; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy* / Q000523:psychology; D010200:Panic / Q000187:drug effects*; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D014635:Valproic Acid / Q000627:therapeutic use*
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D014635:Valproic Acid