c-erbB-2 gene product-like expression in urothelial carcinomas of the human bladder. Its value as a prognostic indicator in superficial tumors.
54 transitional cell carcinomas and 8 mucosal biopsies of the human bladder were stained with monoclonal 3B5 antibody, using three stage peroxidase technique. The antibody is raised against intracytoplasmic domain of the human c-erbB-2 gene product. 37 (69%) carcinomas and 1 specimen with hyperplastic-dysplastic changes, showed positive staining. There was good correlation between c-erbB-2 protein expression and extent of tumor invasion. Correlation with clinical course showed that it was also a good predictor of superficial tumors.
Servizio di Anatomia Patologica dell'Ospedale di Saronno, Varese.
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D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D000912:Antibodies, Neoplasm / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D011519:Proto-Oncogenes; D018719:Erb-b2 Receptor Tyrosine Kinases; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases