Further studies on cold adapted variants of human influenza virus A/Krasnodar/101/59 (H2N2) with special reference to genetic stability of attenuation markers.
A previously described cold adapted (ca) attenuated virus, K/25, derived from parent strain A/Krasnodar/101/59 (H2N2), was further modified by 35 additional passages in chick embryos at suboptimal temperature. The virus obtained had retained a distinct ts and ca phenotype and some other markers of attenuation but differed from formerly isolated ca variants by its higher genetic stability connected with an increased growth capacity in chick embryos.
Panzig
B
B
Institute of Medical Microbiology, University of Greifswald, Germany.
Lisovskaya
K B
KB
Herrmann
B
B
Klimov
A
A
Döhner
L
L
D000818:Animals; D002642:Chick Embryo; D003080:Cold Temperature; D006224:Cricetinae; D005814:Genes, Viral; D005819:Genetic Markers; D014644:Genetic Variation; D053121:Influenza A Virus, H2N2 Subtype; D009980:Influenza A virus / Q000235:genetics* / Q000472:pathogenicity; D010641:Phenotype; D015678:Viral Structural Proteins / Q000235:genetics; D014774:Virulence
D005819:Genetic Markers; D015678:Viral Structural Proteins