[Antistressor effect of delta-sleep-inducing peptide in hypokinetic stress].
The influence of DSIP injection on the levels of neurotransmitters during hypokinetic stress was studied. It was shown that hypokinesia produced considerable changes in the levels of GABA glutamate, aspartate and homocarnosine. The injection of DSIP normalized the level of neurotransmitter amino acids. Administration of DSIP also reduced stress-induced changes in the activity of enzymes of GABA metabolism. Stress protective effect of DSIP was also demonstrated by normalising of the POL of lipids in brain.
Mendzheritskiĭ
A M
AM
Makletsova
M G
MG
Uskova
N I
NI
Choraian
I O
IO
Mikhaleva
I I
II
D000818:Animals; D001224:Aspartic Acid / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002336:Carnosine / Q000031:analogs & derivatives / Q000187:drug effects / Q000378:metabolism; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D005971:Glutamates / Q000187:drug effects / Q000378:metabolism; D018698:Glutamic Acid; D050356:Lipid Metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000188:drug therapy* / Q000201:enzymology; D005680:gamma-Aminobutyric Acid / Q000187:drug effects / Q000378:metabolism
D005971:Glutamates; D018377:Neurotransmitter Agents; D001224:Aspartic Acid; C005038:homocarnosine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D003701:Delta Sleep-Inducing Peptide; D002336:Carnosine
Antistressornyĭ éffekt del'ta-son-indutsiruiushchego peptida pri gipokineticheskom stresse.