[The effect of immunization with Streptococcus group A on the development of delayed hypersensitivity to BCG antigens in mice of different strains].
Antibodies to group A streptococcal polysaccharide (A-PS) have been shown to appear within three weeks after the injection of group A streptococcus culture, heat-killed and treated with pepsin (A-STP), in the blood of not only BALB/c mice, but also CBA mice. As revealed in this study, in BALB/c mice antibodies are mainly active against the group-specific antigenic determinant (AD) of A-PS and in CBA mice, against the rhamnose AD of A-PS, common for streptococci of different groups. This study has revealed that the appearance of antibodies to the rhamnose AD of A-PS in the blood of CBA mice inhibits antigen-specific cytotoxicity, appearing with the development of delayed hypersensitivity to BCG antigens. This effect is not linked with the immunization of the animals with high doses of streptococci. Experiments have shown that the in vitro transfer of the inhibition of antigen-specific cytotoxicity to lymph node cells of normal BCG-sensitized animals may be carried out with lymph node cells of CBA mice, immunized with A-STP and having antibodies to the rhamnose AD of A-PS, but not with the serum containing these antibodies. The mechanisms of this effect are discussed.
Bazanova
E A
EA
Gnezditskaia
E V
EV
Borodiiuk
N A
NA
Liampert
I M
IM
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000276:immunology*; D001500:BCG Vaccine / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007114:Immunization / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001500:BCG Vaccine; D000939:Epitopes; D011135:Polysaccharides, Bacterial
Vliianie immunizatsii streptokokkom gruppy A na razvitie giperchuvstvitel'nosti zamedlennogo tipa k antigenam BTsG u mysheĭ raznykh liniĭ.