Effects of pancuronium and vecuronium on plasma levels of immunoglobulins, IgG, IgM and IgE, in patients undergoing minor gynaecological surgery.
1. The effects of two competitive neuromuscular blocking agents, pancuronium and vecuronium, on plasma levels of immunoglobulins, IgG, IgM and IgE, were studied and compared, using the ELISA assay, in patients undergoing minor gynaecological surgery. 2. The results showed that neither pancuronium (0.1 mg/kg) nor vecuronium (0.1 mg/kg) had any significant effect on IgG, IgM and IgE levels in these patients. However, the underlying trend was that both pancuronium and vecuronium slightly increased the IgG and IgM levels, (by 19.5%, 22.1%, of control IgG, and by 17.3%, 28.8% of control IgM, respectively), with vecuronium being more effective than pancuronium). In addition, pancuronium, but not vecuronium, also slightly increased the IgE levels (by 5.9% of control IgE). Vecuronium, on the other hand, slightly decreased the IgE level (by 4.9% of control IgE). However, these increases or decreases were not statistically significant. 3. The significance of the present results are discussed in relation to changes in immunoglobulins and adverse effects induced by drugs, such as muscle relaxants.
Respiratory and Anesthetics Unit, Hospital for Sick Children, London, U.K.
F A
FA
Wali
V
V
Makinde
A
A
Mahoney
H F
HF
Seeley
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000187:drug effects; D007074:Immunoglobulin G / Q000187:drug effects; D007075:Immunoglobulin M / Q000187:drug effects; D007136:Immunoglobulins / Q000187:drug effects*; D008875:Middle Aged; D010197:Pancuronium / Q000494:pharmacology*; D011897:Random Allocation; D014673:Vecuronium Bromide / Q000494:pharmacology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007073:Immunoglobulin E; D014673:Vecuronium Bromide; D010197:Pancuronium