Different effects of chlorpromazine on bleomycin- and epirubicin induced cytotoxicity.
The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.
Grankvist
K
K
Department of Clinical Chemistry, Umeå University Hospital, Sweden.
Bergström
P
P
Henriksson
R
R
D001761:Bleomycin / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003603:Cytotoxins; D015251:Epirubicin / Q000494:pharmacology*; D005347:Fibroblasts
D003603:Cytotoxins; D001761:Bleomycin; D015251:Epirubicin; D002746:Chlorpromazine