Patch-clamping in slices of mammalian CNS.
A new method has been developed that permits high-resolution patch-clamp recordings in neurones from slice preparations of virtually every region of the brain or spinal cord. Since in these preparations most of the synaptic contacts are intact, the method is particularly interesting for the investigation of the molecular mechanisms of synaptic transmission at identified central neurones.
Konnerth
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Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG.
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D003250:Constriction; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods*; D006652:Histological Techniques; D066298:In Vitro Techniques; D009474:Neurons / Q000502:physiology; D013569:Synapses / Q000502:physiology