Preliminary evidence for noradrenaline and ATP as neurotransmitters in the porcine isolated palmar common digital artery.
Sympathetic neurotransmission in porcine isolated palmar common digital artery involves the release of noradrenaline and ATP which produce constrictor responses via alpha 1-adrenoceptor and P2x receptors, respectively. Responses to short trains of pulses (e.g. 4 pulses at 2Hz) are almost entirely attributable to ATP, while those to longer trains of pulses appear to involve both transmitters. Unlike the corresponding blood vessel in man (Stevens and Mould, 1985) no evidence for "innervated" post-junctional alpha 2-adrenoceptors was found.
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, United Kingdom.
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Blaylock
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VG
Wilson
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D004558:Electric Stimulation; D005552:Forelimb / Q000098:blood supply / Q000294:innervation; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology*; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D013449:Sulfonamides / Q000494:pharmacology*; D013552:Swine; D000096926:Benzenesulfonamides
D000255:Adenosine Triphosphate; D000317:Adrenergic alpha-Antagonists; D018377:Neurotransmitter Agents; D009638:Norepinephrine; D010646:Phentolamine; D011942:Receptors, Adrenergic, alpha; D011983:Receptors, Purinergic; D013449:Sulfonamides; C044648:YM 12617; D000096926:Benzenesulfonamides; C002630:alpha,beta-methyleneadenosine 5'-triphosphate