The modulatory effects of phorbol esters on histamine release from mast cells induced by a polyethylenimine and a polyallylamine.
1. Histamine release from rat peritoneal mast cells induced by polyethylenimine (mol. wt = 600) was inhibited by phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), but not by 4 alpha-phorbol 12,13-didecanoate (4 alpha-PDD). 2. Histamine release induced by polyallylamine (mol. wt = 10,000) was enhanced by PMA and PDBu, but not by 4 alpha-PDD. 3. K-252a reduced the inhibitory effect of PMA on histamine release induced by polyethylenimine and its enhancing effect on histamine release by polyallylamine.
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo, Japan.
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Sekino
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Uchida
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Suzuki-Nishimura
D000818:Animals; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008970:Molecular Weight; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology; D010703:Phorbol Esters / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000494:pharmacology*; D011095:Polyethylenes / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D010703:Phorbol Esters; D011073:Polyamines; D011095:Polyethylenes; C008876:phorbol-12,13-didecanoate; C063994:polyallylamine; D015240:Phorbol 12,13-Dibutyrate; D011094:Polyethyleneimine; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate