Differentiation of the basal cell epithelioma-like changes overlying dermatofibroma.
Epidermis overlying dermatofibroma rarely displays basal cell epithelioma-like changes (BCE-like changes). Based on the histopathological findings, whether BCE-like changes are induced by dermal lesion or adnexal regression secondary to the solid fibrotic growth remains to be explored. From the standpoint of differentiation, we examined the BCE-like changes overlying dermatofibroma, normal epidermis, and hair follicles. PNA and two kinds of anti-keratin monoclonal antibodies were used to detect markers for epidermal differentiation. When PNA and anti-keratin monoclonal antibody (34betaB4) were used, no difference was observed in the staining patterns among BCE-like changes, hair follicles or normal basal cells. With the other anti-keratin antibody (34betaE12), BCE-like changes and normal basal cells were recognized, though the hair matrix was not. Thus the results obtained indicate that normal basal cells show the most similar differentiation to BCE-like changes.
Fujisawa
H
H
Division of Dermatology, Mito National Hospital, Japan.
Matsushima
Y
Y
Hoshino
M
M
Baba
T
T
Uyeno
K
K
D000911:Antibodies, Monoclonal; D002280:Basal Cell Carcinoma / Q000473:pathology*; D005260:Female; D005350:Fibroma / Q000473:pathology*; D006197:Hair / Q000473:pathology; D006801:Humans; D037102:Lectins; D008875:Middle Aged; D019887:Peanut Agglutinin; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal; D037102:Lectins; D019887:Peanut Agglutinin