HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial penicillin-binding proteins.
Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to five bacterial penicillin-binding proteins.
Institute of Pharmacology and Biochemistry, University Zürich-Irchel, Switzerland.
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Hafkemeyer
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Neftel
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Hübscher
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D004257:DNA Polymerase II / Q000032:analysis*; D004926:Escherichia coli / Q000201:enzymology; D006678:HIV / Q000201:enzymology*; D006602:Hexosyltransferases; D006801:Humans; D008969:Molecular Sequence Data; D002267:Muramoylpentapeptide Carboxypeptidase / Q000032:analysis*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D012194:RNA-Directed DNA Polymerase / Q000032:analysis*; D012689:Sequence Homology, Nucleic Acid
D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D012194:RNA-Directed DNA Polymerase; D004257:DNA Polymerase II; D002267:Muramoylpentapeptide Carboxypeptidase