Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis.
Mutagenesis by a variety of chemical mutagens conferred only 1.1- to 2.8-fold increases in mutation frequencies at defined single base sites in vesicular stomatitis virus and poliovirus.
Institute of Molecular Genetics, University of California, San Diego, La Jolla 92093.
J J
JJ
Holland
E
E
Domingo
J C
JC
de la Torre
D A
DA
Steinhauer
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology; D002460:Cell Line; D003062:Codon / Q000235:genetics*; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009608:Nitrous Acid / Q000494:pharmacology; D017955:Poliovirus / Q000187:drug effects / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000235:genetics*
D003062:Codon; D009153:Mutagens; D012333:RNA, Messenger; D005020:Ethyl Methanesulfonate; D001374:Azacitidine; D009608:Nitrous Acid; D005472:Fluorouracil