Morphological changes in spleen, bone marrow and blood of rats after continuous gamma irradiation and indomethacin treatment.
A possibility of modifying the radiation damage of haematopoiesis by indomethacin administered during continuous irradiation was followed. Indomethacin was given in drinking water (average dose of 740.7 micrograms/kg per day) within 7-days continuous irradiation with gamma rays (a daily dose rate of 2.055 Gy, total accumulated dose of 14.385 Gy). Under the given conditions no marked protective effect of indomethacin on haematopoiesis was found with the exception of mild stimulation of myelopoiesis and an increased release of developmentally younger cells of myeloid and erythroid series to the peripheral blood as well.
Department of General Biology, Faculty of Science, P.J. Safárik University, Kosice, CSSR.
N
N
Macková
P
P
Brezáni
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects*
D007213:Indomethacin