[Comparative evaluation of radiotherapy and chemoradiotherapy in inoperable cancer of the esophagus].
The paper is concerned with the results of radiation therapy and three variants of chemoradiotherapy of 174 patients with inoperable esophageal cancer. Altogether 151 (87%) patients were given treatment from beginning to end. Complete tumor regression was noted in 41% of the patients after chemoradiotherapy and in 29%--after radiotherapy. The 2-year survival rates were 28 and 20%, the 5-year survival rates were 8 and 0%, respectively. Among the variants of chemoradiotherapy the most effective one was the combination of 5-FU with bleomycin, in which complete tumor regression was noted in 46% of the patients, and the 2-year survival was 43% versus 25% in the combination of 5-FU with adriamycin and 21% in its combination with methotrexate. Prognostically unfavorable factors were a degree of body mass deficiency, tumor spreading and a tumor site in the esophagus.
B M
BM
Aliev
Kh B
KhB
Khydyrov
N F
NF
Kondrat'eva
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D005069:Evaluation Studies as Topic; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D013997:Time Factors
D001761:Bleomycin; D004317:Doxorubicin; D005472:Fluorouracil; D008727:Methotrexate
Sravnitel'naia otsenka luchevogo i khimioluchevogo lecheniia neoperabel'nogo raka pishchevoda.