The effect of dextran 40 and Dazmegrel on early platelet deposition onto vascular grafts.
Platelet deposition onto double velour Dacron (n = 14) and double velour Dacron with internal collagen (n = 14) interposition grafts were examined experimentally. The accumulation was assessed by reinfusion of 111In labelled platelets and imaging with a scintillation camera. One group received Dextran-40 intravenously (n = 14) and one group received Dazmegrel (n = 14) intravenously. No graft occlusions were noted. Differences in effects of Dextran-40 and Dazmegrel were not observed. The study indicates a beneficial effect of infused Dextran-40 as well as Dazmegrel. The explanation might be reduced interaction graft wall versus blood-platelets.
Pärsson
H
H
Department of Surgery, Lund University, Sweden.
Jönsson
B A
BA
Norgren
L
L
Thörne
J
J
D000818:Animals; D003911:Dextrans / Q000008:administration & dosage*; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D007093:Imidazoles / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011093:Polyethylene Terephthalates; D013552:Swine; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D003911:Dextrans; D007093:Imidazoles; D011093:Polyethylene Terephthalates; C039242:dazmegrel; D013930:Thromboxane-A Synthase