Ischaemia and mediator release: interrelationship in antigen-challenged sensitized guinea-pig kidney.
Renal vasoconstriction and ischaemia that follow in vitro antigen challenge of isolated perfused kidney of sensitized guinea-pig appears to be a self-perpetuating process, starting with a primary peak of release of vasoconstrictor mediators and followed by secondary peaks (particularly of arachidonic acid metabolites) which are probably initiated by ischaemia/reperfusion damage.
Department of Pharmacology, University College London, UK.
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Abdullah
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Assem
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001794:Blood Pressure / Q000187:drug effects; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D066298:In Vitro Techniques; D007511:Ischemia / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply* / Q000276:immunology / Q000378:metabolism; D010047:Ovalbumin / Q000276:immunology; D012079:Renal Circulation / Q000187:drug effects; D013189:SRS-A / Q000378:metabolism; D013929:Thromboxane B2 / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects
D000941:Antigens; D013189:SRS-A; D013929:Thromboxane B2; D010047:Ovalbumin