Drug resistance, the last frontier?
A brief review of the (1990) "state of the art" knowledge concerning multidrug resistance and P-glycoprotein function is presented. Modification and manipulation of the efflux pump by calcium channel blockers and antiestrogens are discussed.
Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
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Kellen
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D004351:Drug Resistance / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D008562:Membrane Glycoproteins