Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine.
To study the vascular effects of a new photosensitizing agent independent of the influence of tumor growth, a cutaneous wound model was used. Six-week-old Harlan-Sprague-Dawley "Fuzzy" rats were surgically wounded in a standard fashion. The animals were then divided into three groups: the first group received chloroaluminum-sulfonated phthalocyanine only, the second group was treated with light only, and a third group was treated with both chloroaluminum-sulfonated phthalocyanine and light. Photodynamic therapy with chloroaluminum-sulfonated phthalocyanine had a direct effect on the neovasculature of a healing wound. The vasodilatation that was seen in the wound neovasculature that occurred 12 hours after the completion of chloroaluminum-sulfonated phthalocyanine-photodynamic therapy may have indicated a therapeutic "window" at which other therapies can be employed to improve clinical efficacy.
Department of Head and Neck Surgery, M.D. Anderson Cancer Center, Houston, TX 77030.
S J
SJ
Stern
S
S
Thomsen
S
S
Small
S
S
Jacques
D000818:Animals; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000473:pathology; D009942:Organometallic Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D010778:Photochemotherapy / Q000379:methods; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000473:pathology
D007211:Indoles; D009942:Organometallic Compounds; D011838:Radiation-Sensitizing Agents; C052736:chloroaluminum tetrasulfophthalocyanine; C044797:chloroaluminum phthalocyanine