[Effect of pyridoxal phosphate on gamma-aminobutyric acid metabolism in different sections of the brain in irradiated animals].
A study was made of the effect of X-rays (4,5 Gy) and pyridoxal phosphate (3 mg/kg, v/v) on the activity of pyridoxal enzymes of GABA metabolism (e.g. glutamate decarboxylase, E.C. 4.1.1.15) and aminobutyrate aminotransferase (GABA-T, E.C. 2.6.1.19), as well as on GABA and glutamate content of the hemisphere cortex, brain stem and cerebellum of rabbits 6 and 10 days following irradiation and injection of a coenzyme. The height of the radiation sickness in rabbits was characterized by the manifest changes in glutamate decarboxylase and GABA-T activity, as well as in GABA and glutamate content of various brain parts differing in the structural and functional functions. The administration of pyridoxal phosphate produced pronounced activation of glutamate decarboxylase, particularly 6 days after irradiation and administration of the co-enzyme, and, to a lesser extent, influenced GABA-T function. Pyridoxal phosphate favored maintaining the GABA level above the control level in the hemisphere cortex and brain stem 6 and 10 days after exposure. The injection of pyridoxal phosphate did not normalize the glutamate content of the brain parts 6 days after exposure, but favored the normalization of GABA-T activity on day 10.
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Tsybul'skiĭ
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ER
Nagiev
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D005260:Female; D005968:Glutamate Decarboxylase / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D005971:Glutamates / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D018698:Glutamic Acid; D008297:Male; D011732:Pyridoxal Phosphate / Q000494:pharmacology*; D011817:Rabbits; D011833:Radiation Injuries, Experimental / Q000378:metabolism; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects
D005971:Glutamates; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate; D005968:Glutamate Decarboxylase
Vliianie piridoksal'fosfata na obmen gamma-aminomaslianoĭ kisloty v razlichnykh otdelakh golovnogo mozga obluchennykh zhivotnykh.