Cerebrospinal fluid monoamine metabolites and neuropeptides in patients with panic disorder.
Concentrations of homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG) as well as somatostatin (SRIF) and beta-endorphin (beta-END) were assayed in the cerebrospinal fluid (CSF) of 34 patients with panic disorder and of ten neurological controls. No aberrations of the monoaminergic or peptidergic variables measured were found in the nonpanic state of patients with panic disorder. A modest correlation (P = 0.04) between total anxiety scores and CSF MHPG was observed.
Vaajasalo Hospital, Kortejoki, Finland.
U
U
Lepola
J
J
Jolkkonen
A
A
Pitkänen
P
P
Riekkinen
R
R
Rimón
D000328:Adult; D001679:Biogenic Amines / Q000134:cerebrospinal fluid*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D010200:Panic; D010698:Phobic Disorders / Q000134:cerebrospinal fluid* / Q000523:psychology; D011581:Psychological Tests; D013004:Somatostatin / Q000134:cerebrospinal fluid; D001615:beta-Endorphin / Q000134:cerebrospinal fluid
D001679:Biogenic Amines; D009479:Neuropeptides; D013004:Somatostatin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D001615:beta-Endorphin; D006719:Homovanillic Acid