[The role of dopamine receptors in controlling mouse aggressivity: the genotype dependence].
Significant genotypic differences in shock-induced aggression were found in mice of eight inbred strains. Aggression was evaluated in test with the action of low electric current through the cage floor. Low aggressive strains C3H/He, DD, BALB/c, AKR and highly aggressive strains CBA, DBA/2. CC57Br were singled out by the number of aggressive attacks. Selective stimulation of dopamine D2 receptors by bromocriptine considerably increased the shock-induced aggressiveness in mice of low-aggressive strains. Blockade of D2-receptors by the injection of antagonist sulpiride decreased or prevented the manifestation of aggression in highly-aggressive mice. At the same time selective agonist of dopamine (D1) receptors SKF 38393 and administration of selective antagonist of D1-receptors SCH 23390 did not influence significantly shock-induced aggression. Thus, shock-induced aggression, depends on the animal genotype and activation of D2-receptors.
Nikulina
E M
EM
Kapralova
N S
NS
D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists; D004558:Electric Stimulation; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D015259:Dopamine Agents; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine
Rol' dofaminovykh retseptorov v kontrole agressivnosti mysheĭ: zavisimost' ot genotipa.