Histaminergic neurons receive substance P-ergic inputs in the posterior hypothalamus of the rat.
The synaptic connections between histaminergic neurons and substance P (SP) afferents in the caudal magnocellular nucleus (CM) of the hypothalamus were examined using an immunoelectron microscopic mirror method. SP-immunoreactive (SP-IR) terminals made synaptic contacts with the somata, somatic spines and dendrites of histidine decarboxylase immunoreactive (HDC-IR) neurons. This suggests that SP afferents exert monosynaptic influence on the central histaminergic neuronal system.
First Department of Anatomy, Osaka City University Medical School, Japan.
R
R
Tamiya
M
M
Hanada
N
N
Narita
S
S
Inagaki
M
M
Tohyama
H
H
Takagi
D000818:Animals; D006632:Histamine / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D007034:Hypothalamus, Posterior / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000378:metabolism*
D013373:Substance P; D006632:Histamine