[Role of polymorphonucleocyte-produced leukotriene B4 in Kawasaki disease].
It is postulated that inflammatory cells play an important role in the process of developing vasculitis in Kawasaki Disease. LTB4, a 5-lipoxygenase product of arachidonic acid is one of the most potent chemoattractants to inflammatory cells and is produced in large amounts by PMNs. We investigated the role of PMN-derived LTB4 in Kawasaki Disease. Isolated PMNs were obtained from 19 Kawasaki disease patients in three different phases of the illness, (acute phase: 0-12th day, convalescent phase: 13-29th day, restored phase: greater than 30th day). LTB4 synthesis in the convalescent phase was 26.43 +/- 4.2 ng/5 x 10(6) cells, which was significantly higher than those in the acute and restored phases (11.90 +/- 1.91, 13.87 +/- 1.86 ng) and also higher than that in the control subjects (10.65 +/- 1.26 ng: p less than 0.05). No differences were found between two groups with or without coronary lesions. The results imply that activated PMNs during the convalescent phase of illness produce larger amount of LTB4 which may participate in the development of inflammatory process of the disease and that PMN-derived LTB4 plays no significant roles in the development of coronary lesions.
Hamasaki
Y
Y
Department of Pediatrics, Saga Medical School.
Miyazaki
S
S
D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007975:Leukotriene B4 / Q000096:biosynthesis*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000628:therapy; D009504:Neutrophils / Q000378:metabolism*; D005719:gamma-Globulins / Q000008:administration & dosage
D005719:gamma-Globulins; D007975:Leukotriene B4; D001241:Aspirin