Chronic treatment with MIF-1 prevents the painful stimuli threshold elevation induced by neonatal handling in mice.
Chronic postnatal stressful handling results in a hyposensitivity to thermal nociceptive stimuli. This phenomenon is strongly affected by manipulations of the opioid system. In the present experiment, we report that chronic treatment with MIF-1 during the neonatal period prevents the behavioral alterations induced by handling while it is completely ineffective if injected acutely before antinociceptive testing by the tail flick test at 45 days of life.
Istituto Superiore di Sanità, Rome, Italy.
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D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D009075:MSH Release-Inhibiting Hormone / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009619:Nociceptors / Q000187:drug effects*; D012684:Sensory Thresholds / Q000187:drug effects; D013312:Stress, Physiological / Q000503:physiopathology
D009075:MSH Release-Inhibiting Hormone