Increased urinary excretion of the histamine metabolite N tau-methylhistamine during acetylsalicylic acid provocation in chronic urticaria patients.
Seventeen chronic urticaria patients with a history suggestive of acetylsalicylic acid (ASA, Aspirin)-intolerance were challenged with ASA; only 2 patients showed marked clinical reactions. These clinical reactions were accompanied by a significant increase in the urinary excretion of the most important histamine metabolite, N tau-methylhistamine, in comparison with 15 non-responders (p less than or equal to 0.05) and placebo test. These results suggest an involvement of histamine in the pathogenesis of ASA-intolerance in chronic urticaria patients.
B.C.O. Centre for Research, Breda, The Netherlands.
E
E
Oosting
S H
SH
Kardaun
H M
HM
Doeglas
P
P
Los
J G
JG
de Monchy
D000328:Adult; D000368:Aged; D001241:Aspirin / Q000009:adverse effects*; D002908:Chronic Disease; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008297:Male; D008761:Methylhistamines / Q000652:urine*; D008875:Middle Aged; D014581:Urticaria / Q000652:urine*
D008761:Methylhistamines; C031205:3-methylhistamine; D001241:Aspirin