[The influence of inhibitors of kinin and prostaglandin formation on the vascular and tubular effects of osmotic diuretics in the kidney].
Mannit was shown to increase the blood flow in the external, middle and internal zone of the renal cortex in anesthetized rats but exerts no effect on the blood supply to the external zone of the medullary layer. A preliminary administration of contrykal fails to influence the diuretic and natriuretic effects of the preparation and to change the character of the hemodynamic shift at the action of the diuretic in the middle zone of the cortical layer. Indomethacin completely eliminates the blood flow increase in the middle zone of the cortex but it does not prevent the diuretic and natriuretic reaction to mannit administration. It is concluded that realization of the vascular and tubular effects of the diuretic is not related to the increase of kinin biosynthesis in the kidneys. Prostaglandins formed in the kidneys under the influence of mannit are involved in the mechanism of dilatation of the vessels of the cortical layer but do not play the significant role in the formation of its tubular effect.
O B
OB
Kuz'min
P V
PV
Mikhaĭlenko
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects / Q000502:physiology; D004234:Diuretics, Osmotic / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007684:Kidney Tubules / Q000187:drug effects* / Q000502:physiology; D007705:Kinins / Q000037:antagonists & inhibitors*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009318:Natriuresis / Q000187:drug effects / Q000502:physiology; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D012079:Renal Circulation / Q000187:drug effects* / Q000502:physiology
D004234:Diuretics, Osmotic; D007705:Kinins; D011448:Prostaglandin Antagonists; D008353:Mannitol; D007611:Aprotinin; D007213:Indomethacin
Vliianie ingibitorov obrazovaniia kininov i prostaglandinov na sosudistyĭ i kanal'tsevyĭ éffekty osmoticheskikh diuretikov v pochke.