Biochemical studies in Presbytis cristata infected with subperiodic Brugia malayi.
The Presbytis cristata--Brugia malayi model, now established as a reliable non-human primate model for the experimental screening of potential filaricides, was monitored at monthly intervals for changes in the liver and renal function tests and also for alkaline phosphatase levels during infection. Animals infected with 200-400 infective larvae became patient at 50-90 days post-infection and geometric mean microfilarial counts were above 1000 per ml from the fourth month onwards. There were no significant changes in the biochemical parameters monitored throughout the period of observation. This is an important observation as any changes seen in these parameters during experimental drug studies can be attributed to drug reaction or toxicity and this will be invaluable in decision making as to drug safety.
Choong
M F
MF
Institute for Medical Research, Kuala Lumpur, Malaysia.
Mak
J W
JW
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001806:Blood Urea Nitrogen; D002009:Brugia / Q000254:growth & development; D002520:Cercopithecidae; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004605:Elephantiasis, Filarial / Q000201:enzymology / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D008842:Microfilariae / Q000254:growth & development; D005723:gamma-Glutamyltransferase / Q000097:blood
D003404:Creatinine; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin