Synthesis and HPLC assessment of N-nitrosoderivatives from six beta-adrenergic antagonists.
At first N-nitrosoderivatives from six beta-adrenergic antagonists of large consumption were prepared. Secondly the standard nitrosation reactions recommended by WHO were performed to get information about their possible in vivo production and the yields of N-nitrosoderivatives were evaluated by HPLC analyses. Pharmacological tests confirm the potential risk to man of the N-nitrosoderivatives studied.
Istituto di Scienze Farmaceutiche Università di Genova, Italy.
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Mazzei
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Sottofattori
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Balbi
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Robbiano
D000319:Adrenergic beta-Antagonists / Q000032:analysis / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008099:Liver / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis / Q000138:chemical synthesis* / Q000633:toxicity; D009603:Nitroso Compounds / Q000032:analysis / Q000138:chemical synthesis* / Q000633:toxicity; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000319:Adrenergic beta-Antagonists; D009153:Mutagens; D009603:Nitroso Compounds