beta A4 amyloid protein deposition in brain after head trauma.
Previous reports have suggested that both repetitive head trauma and a single injury can be associated with the presence of diffuse beta A4 amyloid protein plaques in long-term survivors. We have studied sixteen patients (aged 10-63 years) who sustained head injury and survived for only 6-18 days. Immunostaining with an antibody to beta A4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients (38%). Thus, severe head injury can trigger beta A4 deposition in the brain within days.
Department of Anatomy, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
G W
GW
Roberts
S M
SM
Gentleman
A
A
Lynch
D I
DI
Graham
D000328:Adult; D016229:Amyloid beta-Peptides / Q000032:analysis*; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000737:chemistry; D002648:Child; D006259:Craniocerebral Trauma / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D016229:Amyloid beta-Peptides