Dopamine and dobutamine reduce myocardial d-propoxyphene content in experimentally intoxicated rats.
The effect of sympathomimetic intervention with dopamine or dobutamine on the myocardial uptake of d-propoxyphene was investigated experimentally in rats. The d-propoxyphene (19 mg kg-1 h-1) was continuously infused, intravenously, over 45 min. After 20 min of infusion the rats were given either dopamine (12.5 micrograms kg-1 min-1 or 25 micrograms kg-1 min-1), dobutamine (25 micrograms kg-1 min-1 or 45 micrograms kg-1 min-1) or normal saline (control). Each group consisted of eight rats. The myocardial d-propoxyphene content was significantly lower in the two groups given dopamine and in the group given dobutamine 45 micrograms kg-1 min-1 than in the control group (P less than 0.05). This finding indicates the benefit of early sympathomimetic intervention with either dopamine or dobutamine in d-propoxyphene intoxication.
Pedersen
C B
CB
Department of Anaesthesia and Intensive Care, Municipal Hospital of Copenhagen, Denmark.
Strøm
J
J
Angelo
H R
HR
Munksgaard
A
A
Høgskilde
S
S
Bredgaard Sørensen
M
M
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D011431:Dextropropoxyphene / Q000378:metabolism* / Q000506:poisoning*; D004280:Dobutamine / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew
D004280:Dobutamine; D011431:Dextropropoxyphene; D004298:Dopamine