[Enhanced resistance to emotional stress through the use of D-phenylalanine].
Stress-protective action was studied of D-phenylalanine, having an ability to decrease destruction of endogenic enkefalins. In the experiments stability of the experimental (receiving D-phenylalanine) and control groups of male rats of August line to emotional stress was compared in conditions of immobilization stress by parameters of animals survival rate, adrenal glands hypertrophy development, involution of thymus, pathologic changes in lungs (abscesses development), ulcero-dystrophic disturbances in stomach, and also the activity and kinetic properties of enzyme tyrosin-hydroxylase in the hypothalamus were determined. It was shown that by several of the mentioned physiological parameters the D-phenylalanine significantly increased the animals stability to the emotional stress and decreased tyrosinhydroxylase activity which participates in activation of katecholaminergic processes.
Iumatov
E A
EA
Sarychev
E I
EI
Kozlovskiĭ
I I
II
Mineeva
M F
MF
Demidov
V M
VM
Morozov
I S
IS
Kozlovskaia
M M
MM
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006358:Hot Temperature / Q000009:adverse effects; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010649:Phenylalanine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000187:drug effects / Q000378:metabolism
D010649:Phenylalanine; D014446:Tyrosine 3-Monooxygenase
Povyshenie ustoĭchivosti k émotsional'nomu stressu s pomoshch'iu D-fenilalanina.