Effects of serotonin and ketanserin on the functional morphology of chick down feather bulbi in vitro.
Chick feather bulbi cultured in vitro showed an increased DNA synthesis and a delayed keratinization after treatment with ketanserin, a serotonin2 antagonist with wound-healing properties. In contrast, serotonin stimulates keratinization of the keratinocytes in the bulbus.
Beele
H
H
Laboratory for Histology, State University of Gent, Belgium.
Thierens
H
H
Verhasselt
B
B
de Ridder
L
L
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D003470:Culture Media; D003584:Cytological Techniques; D004247:DNA / Q000096:biosynthesis; D005241:Feathers / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007633:Keratins / Q000378:metabolism; D007650:Ketanserin / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*
D003470:Culture Media; D012701:Serotonin; D007633:Keratins; D004247:DNA; D007650:Ketanserin