Role of central serotonergic systems in the development of hypertension in spontaneously hypertensive rats.
The spontaneously hypertensive rat (SHR) maintained a higher blood pressure level at and after 8 weeks old than the genetical control Wistar-Kyoto strain (WKY). At 10 weeks old, the turnover rate of 5-hydroxytryptamine (5-HT) was lower in the hypothalamus of SHR than of WKY. Following portacaval anastomosis (PCA) in SHR, the blood pressure was significantly decreased in comparison with that of sham-operated control SHR. In WKY, no significant change in the blood pressure response was observed. PCA treatment increased the 5-HT turnover including that in SHR. If the SHR with PCA was bred with food pellets containing higher concentrations of leucine and isoleucine, the blood pressure increased and the 5-HT turnover decreased. These findings suggest that the central serotonergic system is involved in the development of hypertension.
Department of Pharmacology, Nihon University School of Medicine, Tokyo, Japan.
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Kubo
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Ito
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Shibanoki
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Kogure
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Ishikawa
D000714:Anastomosis, Surgical; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D007031:Hypothalamus / Q000378:metabolism* / Q000503:physiopathology; D011169:Portal Vein / Q000601:surgery; D051381:Rats; D011918:Rats, Inbred SHR / Q000378:metabolism*; D011919:Rats, Inbred Strains / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism* / Q000502:physiology; D014682:Vena Cava, Inferior / Q000601:surgery
D002395:Catecholamines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid