[Molecular and genetic approaches to the study of the regulation of the function of T-suppressor cells specific for histocompatibility molecule epitopes].
Using the model of T-suppression (Ts) induction by i/v injection of irradiated allogeneic splenocytes we were able to show that such specific Ts (1) have their own precursors and express unique membrane markers; that (2) the genetic restriction of Ts/responder interaction (interactional restriction) is based on the direct contact of an Ia molecule on Ts membrane and a putative syngeneic anti-Ia receptor, which appears on the membrane of responder lymphocyte after its activation by an allo-antigen; and that (3) the Ts receptors unlike that of other T-subsets recognize simple serologically defined determinants in the context of an MHC molecule. The practical application of the information of the Ts properties is discussed.
B D
BD
Brondz
A V
AV
Chervonskiĭ
M B
MB
Zaĭtseva
D000818:Animals; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D051381:Rats; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000939:Epitopes
Molekuliarnye i geneticheskie podkhody k izucheniiu reguliatsii funktsii T-supressorov, spetsifichnykh k épitopam molekuly gistosovmestimosti.