The effect of the uptake of particles on the chemotaxis of polymorphonuclear leucocytes in-vitro.
The relationship between the phagocytic uptake of latex microspheres (1.1 microns diam.) and the mobility of rat polymorphonuclear leucocytes (PMNLs) has been investigated in-vitro. The movement of PMNLs was found to be independent of the uptake of particles but about half of the PMNLs were not receptive to the chemo-attractant N-formylmethionyleucylphenylalanine. However, the uptake of particles was greater when particle/cell ratios were high and the greatest number of particles were carried into a cellulose nitrate filter by chemotaxis at the highest particle/cell ratio of 30:1.
Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
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R
Hyde
D A
DA
Lewis
P W
PW
Taylor
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008863:Microspheres; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains
D009240:N-Formylmethionine Leucyl-Phenylalanine