CD8+ T cells from HIV-1-infected individuals inhibit acute infection by human and primate immunodeficiency viruses.
T lymphocytes expressing the CD8 surface antigen block HIV replication in CD4+ peripheral blood cells from HIV-infected individuals. We report here that CD4+ cells from HIV seronegative donors, when infected in vitro with HIV, also do not replicate virus when cocultured with CD8+ T cells from HIV-infected individuals. CD8+ cells from HIV-uninfected donors did not show this effect on virus replication. HLA-restriction of the antiviral response was not observed, and virus-containing cells were not eliminated from culture. The antiviral activity was broadly cross-reactive, as CD8+ cells from individuals infected only with HIV-1 suppressed the replication of diverse strains of HIV-1 and HIV-2, as well as the simian immunodeficiency virus. This ability of CD8+ cells to control HIV replication could play an important role in the maintenance of an asymptomatic state in HIV-infected individuals.
Cancer Research Institute, University of California School of Medicine, San Francisco 94143.
C M
CM
Walker
G A
GA
Thomson-Honnebier
F C
FC
Hsueh
A L
AL
Erickson
L Z
LZ
Pan
J A
JA
Levy
D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology*; D016827:CD8 Antigens; D002470:Cell Survival; D003429:Cross Reactions; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000254:growth & development / Q000276:immunology; D015498:HIV-2 / Q000254:growth & development / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D015302:Simian Immunodeficiency Virus / Q000254:growth & development / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014779:Virus Replication
D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens