Biogenic amines and GABA in the larval and adult forms of the nematode Nippostrongylus brasiliensis.
1. Simultaneous detection (HPLC and electrochemical detection) of biological extracts of larval and adult stages of Nippostrongylus brasiliensis was performed in order to assay biogenic amines. 2. Gamma-amino-butyric acid was assayed in the same samples. 3. Tryptophan, 5-hydroxyindoleacetic acid were at the same level in adults and larvae. 4. 5-Hydroxytryptophan, serotonin, dihydroxyphenylalanine and dopamine were significantly higher in larvae in which gamma-amino-butyric acid was not detected.
Laboratorie de Pharmacodynamie, Université de Paris-Sud, Châtenay-Malabry, France.
H
H
Barreteau
J H
JH
Trouvin
F
F
Goudey-Perrière
C
C
Jacquot
P
P
Gayral
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D005243:Feces / Q000382:microbiology; D007814:Larva / Q000378:metabolism; D009559:Nippostrongylus / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001679:Biogenic Amines; D005680:gamma-Aminobutyric Acid