[Synthesis of leukotrienes B4 and C4 in the gastric mucosa in peptic ulcer].
Forty patients suffering from peptic ulcer were examined for concentrations of leukotrienes B4 and C4 as compared to the activity of myeloperoxidase in the periulcerous zone of the gastric mucosa. 20 healthy persons made up the control. It is assumed that the rise of leukotrienes B4 and C4 concentrations as well as myeloperoxidase activation contribute to chronic inflammation in the periulcerous zone. Chronic inflammation of the gastric mucosa is regarded as an important pathogenetic factor of ulcerogenesis.
Pasechnikov
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VD
D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000209:etiology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis*; D008084:Lipoxygenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy / Q000378:metabolism*; D009195:Peroxidase / Q000187:drug effects; D013189:SRS-A / Q000096:biosynthesis*
D001095:Arachidonic Acids; D006635:Histamine H2 Antagonists; D013189:SRS-A; D007975:Leukotriene B4; D016718:Arachidonic Acid; D009195:Peroxidase; D008084:Lipoxygenase
Sintez leĭkotrienov B4 i C4 v slizistoĭ obolochke zheludka pri iazvennoĭ bolezni.