'Flagellate' erythema from bleomycin. With histopathological findings suggestive of inflammatory oncotaxis.
A case of erythema in a 'flagellate' pattern due to administration of bleomycin in a patient with Hodgkin's disease is described. Emphasis is placed on the low dose of bleomycin administered--15 mg parenterally--and the short time interval between drug administration and beginning of symptoms: 24 h. The histopathological findings were consistent with a mechanism of inflammatory oncotaxis: the attraction of tumor cells by the skin perhaps due to the bleomycin accumulated and the trauma caused by scratching subsequent to pruritus.
Departamento de Dermatologia, Hospital General Universitario, Salamanca, España.
P
P
Cortina
J A
JA
Garrido
J F
JF
Tomas
P
P
Unamuno
M
M
Armijo
D000328:Adult; D001706:Biopsy; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004890:Erythema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans
D001761:Bleomycin