Suppression of actively induced and passively transferred experimental allergic neuritis by cyclosporin A.
The effect of cyclosporin A (CyA) on experimental allergic neuritis (EAN) was examined. CyA suppressed the development of actively induced EAN. The earlier treatment with CyA was begun, the more effective was its effect. CyA was effective even after the development of clinical signs. In actively induced EAN, cessation of CyA treatment lead to the development of EAN. However, in passively induced EAN, it did not. We could not find any differences in the distribution of infiltrating T cell subsets between the control group and the CyA-treated group.
Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Japan.
H
H
Nakayasu
K
K
Ota
H
H
Tanaka
H
H
Irie
K
K
Takahashi
D000818:Animals; D000906:Antibodies / Q000032:analysis; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007150:Immunohistochemistry; D004676:Myelin Basic Protein / Q000276:immunology; D018996:Myelin P2 Protein; D009186:Myelin Sheath / Q000276:immunology; D009420:Nervous System / Q000473:pathology; D009444:Neuritis, Autoimmune, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000517:prevention & control; D051381:Rats; D011917:Rats, Inbred Lew; D012016:Reference Values
D000906:Antibodies; D003524:Cyclosporins; D004676:Myelin Basic Protein; D018996:Myelin P2 Protein