Failure of a 21-aminosteroid antioxidant to ameliorate cisplatin-induced nephrotoxicity.
1 Lazaroid (U74500A), a 21-aminosteroid antioxidant, was administered to rats at a dose of 10 mg kg-1 in an attempt to reduce the toxicity of cisplatin (5 mg kg-1). 2 No protective effect was apparent under the schedule used and, in contrast to other antioxidants and free-radical scavengers, U74500A offers no potential benefit in cisplatin treatment.
Department of Pharmacology and Therapeutics, University of Liverpool, UK.
J D
JD
Holding
P M
PM
Stell
W E
WE
Lindup
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000008:administration & dosage / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D005260:Female; D007668:Kidney / Q000737:chemistry / Q000187:drug effects*; D008315:Malondialdehyde / Q000032:analysis; D010984:Platinum / Q000032:analysis; D011281:Pregnatrienes / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000975:Antioxidants; D011281:Pregnatrienes; D010984:Platinum; D008315:Malondialdehyde; D003404:Creatinine; C053356:U 74500A; D002945:Cisplatin