The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.
Interaction with antigen-presenting accessory cells is thought to be an important step in B-cell activation, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells.
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
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D000595:Amino Acid Sequence; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D001483:Base Sequence; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules; D003001:Cloning, Molecular; D004912:Erythrocytes / Q000276:immunology*; D007163:Immunosorbent Techniques; D037102:Lectins; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009000:Monocytes / Q000276:immunology*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000032:analysis; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D012397:Rosette Formation; D012689:Sequence Homology, Nucleic Acid; D051918:Sialic Acid Binding Ig-like Lectin 2; D014162:Transfection; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D015815:Cell Adhesion Molecules; D037102:Lectins; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D011947:Receptors, Antigen, B-Cell; D011994:Recombinant Proteins; D051918:Sialic Acid Binding Ig-like Lectin 2; D012313:RNA