Endocrine and amine responses to D,L-fenfluramine in normal subjects.
To investigate indirectly the central neurotransmitter mechanisms of D,L-fenfluramine-induced hormone release, prolactin, adrenocorticotropic hormone, cortisol, growth hormone, 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5HIAA) responses to D,L-fenfluramine (60 mg, oral) were examined in a single-blind, placebo-controlled trial in 14 normal subjects. As compared with placebo, D,L-fenfluramine significantly increased both prolactin and cortisol. There was a significant correlation between the cortisol and prolactin responses. HVA levels were also significantly increased, but there were no changes in MHPG or 5HIAA. The elevation in HVA significantly correlated with increases in both prolactin and cortisol. These findings are consistent with recent animal studies suggesting that D,L-fenfluramine-induced prolactin and cortisol release may be mediated, at least in part, by catecholaminergic systems.
School of Psychiatry, University of New South Wales, Sydney, Australia.
P B
PB
Mitchell
G A
GA
Smythe
D000328:Adult; D000368:Aged; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000097:blood*; D011388:Prolactin / Q000097:blood; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000097:blood; D016037:Single-Blind Method
D006728:Hormones; D018377:Neurotransmitter Agents; D011985:Receptors, Serotonin; D005277:Fenfluramine; D012701:Serotonin; D011388:Prolactin; D006854:Hydrocortisone; D006719:Homovanillic Acid