[The effect of lipomodulators on the antigen-specific reactivity of the respiratory pathways].
Studies of guinea pigs subjected to intragastric administration of lipomodulators within the period of inductive phase sensibilization development have revealed that intensity of the contractile reaction of isolated tracheal rings depends on the specific allergen. Cholesterol promoted an increase in the contractile activity of tracheal rings. The administration of clofibrate blocked the formation of antigen-specific tracheal reactivity in the sensibilized animals.
Bashmakov
Iu K
IuK
D000485:Allergens / Q000276:immunology; D000818:Animals; D002784:Cholesterol / Q000494:pharmacology*; D002994:Clofibrate / Q000494:pharmacology*; D000939:Epitopes / Q000502:physiology*; D006168:Guinea Pigs; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000503:physiopathology; D007009:Hypolipoproteinemias / Q000139:chemically induced / Q000503:physiopathology; D007114:Immunization; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000503:physiopathology; D012130:Respiratory Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D014132:Trachea / Q000503:physiopathology
D000485:Allergens; D000939:Epitopes; D002784:Cholesterol; D002994:Clofibrate
Vliianie lipomoduliatorov na antigenspetsificheskuiu reaktivnost' dykhatel'nykh puteĭ.