Mapping of the glycine receptor alpha 2-subunit gene and the GABAA alpha 3-subunit gene on the mouse X chromosome.
We have mapped the gene for the alpha 2-subunit of the inhibitory glycine receptor (Glra2) to the telomeric end of the mouse X chromosome by backcross analysis of a Mus musculus/Mus spretus interspecific cross. In addition, we have extended the mapping of the GABAA alpha 3-subunit receptor gene (Gabra3). A deduced gene order of cen-Cybb-Hprt-DXPas6-Gabra3-Rsvp-Gdx/Cf-8- Dmd-Pgk-1-DXPas2-Plp-DXPas1-Glra2-tel places Gabra3 proximal to the visual pigment gene Rsvp and Glra2 in the region of loci for hypophosphatemia (Hyp), steroid sulfatase (Sts), and the E1 alpha-subunit of pyruvate dehydrogenase (Pdha1). This establishes the XF region of the mouse X chromosome as homologous with the Xp22.1-p22.3 region of the human X chromosome and indicates the presence of an evolutionary breakpoint in the region of Xp21.3.
MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, United Kingdom.
J M
JM
Derry
P J
PJ
Barnard
D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005796:Genes; D005819:Genetic Markers; D006801:Humans; D051379:Mice / Q000235:genetics*; D009115:Muridae / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D011963:Receptors, GABA-A / Q000235:genetics*; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter / Q000235:genetics*; D013045:Species Specificity; D014960:X Chromosome
D005819:Genetic Markers; D011963:Receptors, GABA-A; D018009:Receptors, Glycine; D017981:Receptors, Neurotransmitter