Influence of active immunization of rats with conjugated serotonin-protein antigen on the content of biogenic amines in the brain and on behavioral responses.
The influence of induction of antibodies to the neuromediator serotonin in the case of active immunization of animals with a conjugate serotonin-protein antigen on the distribution of biogenic amines in the brain and on behavioral responses was investigated in experiments on rats. It was shown that active immunization of rats with a serotonin-protein conjugate leads to a decrease in serotonin, its metabolite 5-hydroxyindole-3-acetic acid, as well as dopamine in certain brain structures. Against a background of induction of antibodies to serotonin, the horizontal motor activity of the animals is decreased.
Laboratory of Pathophysiology of the Immune System, Academy of Medical Sciences of the USSR, Moscow.
L A
LA
Basharova
L A
LA
Vetrilé
V A
VA
Evseev
E A
EA
Gromova
N V
NV
Bobkova
L A
LA
Plakzhinas
L E
LE
Fast
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001323:Autoantibodies / Q000276:immunology*; D001679:Biogenic Amines / Q000378:metabolism* / Q000502:physiology; D001921:Brain / Q000276:immunology / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007114:Immunization; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000276:immunology* / Q000502:physiology
D001323:Autoantibodies; D001679:Biogenic Amines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine