Reticulate pigmentation due to bleomycin: light- and electron-microscopic studies.
An unusual case of extensive reticulate pigmentation due to bleomycin is reported. Light- and electron-microscopic studies showed a marked increase of melanin pigment in the basal keratinocytes and a number of melanophages in the upper dermis. The number of melanocytes appeared to be normal. Electron microscopy also revealed damage to subcellular organelles. The increase in pigmentation is thought to be a consequence of this focal damage.
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK.
A L
AL
Wright
S S
SS
Bleehen
A E
AE
Champion
D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D008297:Male; D008543:Melanins / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000648:ultrastructure
D008543:Melanins; D001761:Bleomycin