[Fundamental research--a basis for the synthesis of new hypotensive drugs].
The paper presents the data showing the important significance of basic research into the mechanisms of circulation regulation in synthesizing new classes of antihypertensive agents. It also considers the hemodynamic mechanisms responsible for the antihypertensive effect of calcium antagonists, postsynaptic alpha 1-adrenoreceptor blockers and angiotensin-converting enzyme blockers to treat hypertensive disease. The paper gives the data suggesting the effects of the drugs on the adrenergic and humoral mechanisms of vascular tone regulation.
V A
VA
Almazov
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EV
Shliakhto
D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D001808:Blood Vessels / Q000187:drug effects* / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D015195:Drug Design; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D012106:Research
D000317:Adrenergic alpha-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers
Fundamental'nye issledovaniia--osnova sinteza novykh gipotenzivnykh sredstv.