Caudate hyperintensities in elderly depressed patients with neuroleptic-induced parkinsonism.
Elderly patients are particularly sensitive to the neurologic side effects of psychotropic medications. This increased sensitivity may be related to brain structural changes associated with aging. In this pilot study, the authors report on the occurrence of caudate hyperintensities, using brain magnetic resonance imaging, in seven elderly depressed subjects who developed neuroleptic-induced parkinsonism. Caudate hyperintensities were not observed in any of the seven healthy elderly controls examined. These results suggest that caudate hyperintensities may render some elderly depressed patients susceptible to neuroleptic-induced parkinsonism.
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110.
G S
GS
Figiel
K R
KR
Krishnan
P M
PM
Doraiswamy
C B
CB
Nemeroff
D000368:Aged; D000369:Aged, 80 and over; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002421:Caudate Nucleus / Q000187:drug effects* / Q000473:pathology; D003863:Depression / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000150:complications / Q000473:pathology*; D010865:Pilot Projects
D014150:Antipsychotic Agents