Neurotrophic factors in regeneration.
Nerve growth factor, fibroblast growth factor, and ciliary neurotrophic factor can protect selected populations of neurons from some of the degenerative changes that otherwise follow axonal injury or other insults. The function of diffusible neurotrophic factors in axonal regeneration is still unclear, however. Knowledge of the nerve growth factor congeners, brain-derived neurotrophic factor and neurotrophin-3, is advancing rapidly as is the identification of neurotrophin receptors, several of which are membrane-bound tyrosine kinases.
Division of Neurosurgery, Montreal General Hospital, Canada.
P M
PM
Richardson
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor; D020934:Ciliary Neurotrophic Factor; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*
D019208:Brain-Derived Neurotrophic Factor; D020934:Ciliary Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D005346:Fibroblast Growth Factors