Effect of ochratoxin A on brush border enzymes of rat kidney.
Ochratoxin A was given orally at 60 microgram/kg body weight in neutral olive oil to Fischer rats for 30 days, at which time they were killed. Clinical state, weights of animals and of their organs and urea and creatinine concentrations were not affected during the exposure period. Significant increases in the activity of enzymes in urine were found: 60% increase in alanine aminopeptidase, 45% increase in gamma-glutamyl-transferase and 90% increase in alkaline phosphatase. These changes indicate early pathological changes in the kidney. Relatively small amounts of the toxin thus affect kidney membrane cells.
Pepeljnjak
S
S
Institute of Microbiology, Faculty of Pharmacy and Biochemistry, Zagreb, Yugoslavia.
Cepelak
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I
Juretić
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D
D000469:Alkaline Phosphatase / Q000652:urine; D000626:Aminopeptidases / Q000652:urine; D000818:Animals; D018826:CD13 Antigens; D007674:Kidney Diseases / Q000139:chemically induced / Q000201:enzymology*; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000201:enzymology; D015651:Mycotoxicosis / Q000201:enzymology* / Q000209:etiology; D009793:Ochratoxins / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344; D005723:gamma-Glutamyltransferase / Q000652:urine
D009793:Ochratoxins; C025589:ochratoxin A; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000626:Aminopeptidases; D018826:CD13 Antigens