A proximal mouse chromosome 9 linkage map that further defines linkage groups homologous with segments of human chromosomes 11, 15, and 19.
A 42-cM map of proximal mouse chromosome 9, including eight loci defined by restriction fragment length variants, has been generated. Linkage was established by haplotype analyses of 114 interspecific backcross mice and indicated the following gene order: (centromere) Pvs-5.3 cM-Icam-1/Ldlr-18.4 cM-Thy-1-1.8 cM-Ncam-0.9 cM-Hexa-7.9 cM-Gsta-7.9 cM-Trf. Three of these loci, Pvs, Icam-1, and Hexa, have not been mapped previously. Together with previous mapping studies the current results suggested that chromosomal segments of mouse chromosomes 7 and 9 and chromosomal segments of human chromosomes 11, 15, and 19 derive from a single putative primordial chromosome. The studies support the postulate that detailed analysis of chromosome organization will be useful in defining events in mammalian evolution.
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
M F
MF
Seldin
A M
AM
Saunders
J M
JM
Rochelle
T A
TA
Howard
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002888:Chromosomes, Human, Pair 19; D003433:Crosses, Genetic; D015342:DNA Probes; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009115:Muridae; D012150:Polymorphism, Restriction Fragment Length; D013045:Species Specificity
D015342:DNA Probes