Do some tyrosine hydroxylase-immunoreactive neurons in the human ventrolateral arcuate nucleus and globus pallidus produce only L-dopa?
The presence of 'tyrosine hydroxylase (TH)-only'-immunoreactive (IR) neurons is reported for the first time in the human hypothalamic region and basa ganglia, using immunohistochemical technique. 'TH-only'-IR neurons were demonstrated in the ventrolateral part of the arcuate nucleus and medial segment of globus pallidus. These neurons lacked aromatic L-amino acid decarboxylase (AADC)-, dopamine-beta-hydroxylase (DBH)-, and dopamine (DA)-immunoreactivity. The above results suggest that these 'TH-only'-IR neurons are not dopaminergic, and possibly contain L-DOPA as an end-product.
Komori
K
K
Department of Anatomy, School of Medicine, Fujita Health University, Toyoake, Japan.
Fujii
T
T
Nagatsu
I
I
D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism*; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000032:analysis; D001479:Basal Ganglia / Q000378:metabolism; D004298:Dopamine / Q000032:analysis; D004299:Dopamine beta-Hydroxylase / Q000032:analysis; D005917:Globus Pallidus / Q000378:metabolism*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D007231:Infant, Newborn; D007980:Levodopa / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000378:metabolism*
D007980:Levodopa; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase; D001142:Aromatic-L-Amino-Acid Decarboxylases; D004298:Dopamine