Molecular changes in carbohydrate antigens associated with cancer.
Oncogenic transformation is often associated with aberrant glycosylation in experimental and human tumors. The carbohydrate epitopes, resulting either from incomplete synthesis or neosynthesis, accumulate in high density, possibly in a novel conformation, at the tumor cell surface. A variety of monoclonal antibodies have been developed that recognize tumor-associated carbohydrate antigens and their aberrant organization at the cell surface. These carbohydrate epitopes and the antibodies specific to these structures are being exploited to develop novel diagnostic tools and therapeutic strategies for cancer.
Singhal
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A
Biomembrane Institute, Seattle, WA 98119.
Hakomori
S
S
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D002240:Carbohydrate Sequence; D002471:Cell Transformation, Neoplastic; D000939:Epitopes / Q000032:analysis; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000032:analysis / Q000276:immunology*
D000951:Antigens, Neoplasm; D000939:Epitopes; D009844:Oligosaccharides