An experimental design based quantitative structure-activity relationship study on beta-adrenergic blocking agents using PLS.
Quantitative structure-activity relationships for some beta-adrenergic blocking agents of phenoxyaminopropanol type are established with the PLS method. The basic model is based on a carefully selected training set using experimental design techniques.
Norinder
U
U
Astra Research Centre AB, Södertälje, Sweden.
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D015999:Multivariate Analysis; D011412:Propanolamines / Q000494:pharmacology; D012107:Research Design; D013329:Structure-Activity Relationship
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines