Lindane-induced liver oxidative stress.
The development of an oxidative stress condition in the liver by lindane intoxication is discussed as a possible hepatotoxic mechanism of the insecticide. Lindane is metabolized by liver microsomal enzymes to a variety of metabolites, which are susceptible of conjugation for proper elimination. In addition, the interaction of lindane with the liver tissue results in the induction of the microsomal cytochrome P-450 system, together with enhanced rates of superoxide radical generation and a significant increase in indicators of lipid peroxidation. Concomitantly, lindane intoxication induces a derangement of some antioxidant mechanisms of the liver cell, including decreased superoxide dismutase and catalase activities and alterations in reduced glutathione content leading to depressed GSH/GSSG ratios. The time course study of the changes in hepatic lipid peroxidation and antioxidant parameters are closely interrelated and coincide with the onset and progression of morphological lesions.
Department of Biological Sciences, Faculty of Medicine, University of Chile, Santiago.
L A
LA
Videla
S B
SB
Barros
V B
VB
Junqueira
D000818:Animals; D000975:Antioxidants; D005609:Free Radicals; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D015227:Lipid Peroxidation; D008862:Microsomes, Liver / Q000378:metabolism* / Q000473:pathology; D010100:Oxygen / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D001556:Hexachlorocyclohexane; D010100:Oxygen