Cymelarsan in the treatment of buffaloes naturally infected with Trypanosoma evansi in south China.
Forty buffaloes naturally infected with Trypanosoma evansi in the South of China were treated with a single dose of a new arsenical. Cymelarsan (Mel Cy) at 0.25 mg/kg to 3.0 mg/kg by intramuscular injection. All animals were cured, with the exception of two out of four animals treated with 0.25 mg/kg Mel Cy which relapsed two months after drug administration. Two out of eight buffaloes in control groups treated with a single dose of diminazene aceturate (Berenil), 3.5 mg/kg, relapsed two months after treatment. All cured animals showed no trypanosomes in their blood when tested within one to three years after administration. A scleroma about 2 to 3.5 cm in diameter was found at the site of injection at the dose of 1.5 mg/kg Mel Cy in three of eight animals. At a dose of 3 mg/kg, Mel Cy induced obvious necrosis of the tissue at the site of injection. The results of field application proved that Mel Cy is a very active trypanocidal drug against T. evansi.
Lun
Z R
ZR
Department of Biology, Zhongshan University, Guangzhou, People's Republic of China.
Min
Z P
ZP
Huang
D
D
Liang
J X
JX
Yang
X F
XF
Huang
Y T
YT
D000818:Animals; D001152:Arsenicals / Q000627:therapeutic use*; D002020:Buffaloes / Q000469:parasitology*; D004133:Diminazene / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D009132:Muscles / Q000473:pathology; D009336:Necrosis; D012008:Recurrence; D012867:Skin / Q000473:pathology; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014352:Trypanosomiasis / Q000188:drug therapy / Q000662:veterinary*
D001152:Arsenicals; D014344:Trypanocidal Agents; C062789:melaminylthioarsenate; C003915:diminazene aceturate; D004133:Diminazene