[The short-term and long-lasting changes in DNA and RNA synthesis in the cerebral cortex cells of animals subjected to hypoxia and nerve tissue transplantation].
The DNA and RNA synthesis in the cells of the brain cortex of intact rats and animals subjected to hypoxia, hypoxia with subsequent transplantation or by the local brain injury has been investigated. The DNA synthesis changes insignificantly in the case of hypoxia, it enhances slightly in the area of the injury and increases much more after transplantation. The RNA synthesis decreases considerably immediately after hypoxia and decreases much more 120 days later. Using the ultracentrifuge method it has been found that under the effect of hypoxia the number of nervous cells decreases, the number of glial cells does not change. The local injury in the nervous tissue enhances abruptly the synthesis in neurons and glial cells in the hypoxia-exposed animals, the embryonic nervous tissue transplantation normalizes the number of neurons in the specimens under study and the RNA synthesis in the neurons and glial cells.
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D000818:Animals; D002478:Cells, Cultured / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism* / Q000601:surgery; D004247:DNA / Q000096:biosynthesis*; D004622:Embryo, Mammalian; D005260:Female; D002534:Hypoxia, Brain / Q000378:metabolism*; D009417:Nerve Tissue / Q000637:transplantation*; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D012313:RNA; D004247:DNA
Kratkovremennye i dlitel'no sokhraniaiushchiesia izmeneniia sinteza DNK i RNK v kletkakh kory mozga zhivotnykh, podvergnutykh gipoksii i transplantatsii nervnoĭ tkani.