Effects of pirenzepine on CCK-stimulated canine pancreatic exocrine secretion.
1. The effects of the anticholinergic compound pirenzepine on pancreatic secretion stimulated by intravenous infusions of increasing doses of CCK (0.025-0.4 Ivy Dog Unit/kg/min) were investigated in fasting anaesthetized dogs. 2. Pirenzepine (0.75 mg/kg i.v.) slightly reduced the increases in the pancreatic juice secretion evoked by CCK. 3. Similar results were obtained with others anticholinergic compounds as atropine (3 mg/kg i.v.) and hexametonium (5 mg/kg i.v.).
Department of Physiology, Faculty of Veterinary Science, University of Extremadura, Caceres, Spain.
G M
GM
Salido
M Z
MZ
Gil
J A
JA
Pariente
M J
MJ
Pozo
J A
JA
Madrid
D000681:Amylases / Q000378:metabolism; D000758:Anesthesia; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002766:Cholecystokinin / Q000494:pharmacology*; D004285:Dogs; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism; D010890:Pirenzepine / Q000494:pharmacology*
D006584:Hexamethonium Compounds; D010890:Pirenzepine; D001285:Atropine; D002766:Cholecystokinin; D000681:Amylases