Pharmacological modulation by cetirizine and ebastine of the cutaneous reactivity to histamine.
The peripheral H1-inhibiting effects of cetirizine 10 mg and ebastine 10 mg were compared at the skin level after single oral administration. The study was performed in 9 healthy subjects under double-blind randomized crossover conditions. Both drugs were significantly effective up to 24 h. The suppressive effect of cetirizine was significantly more rapid and more marked.
Rivest
J
J
Unité de Dermatologie professionnelle et de l'Environnement, UCL 3033, Bruxelles, Belgique.
Despontin
K
K
Ghys
L
L
Rihoux
J P
JP
Lachapelle
J M
JM
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000328:Adult; D002090:Butyrophenones / Q000008:administration & dosage / Q000494:pharmacology*; D002214:Capsules; D017332:Cetirizine; D004311:Double-Blind Method; D005260:Female; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006967:Hypersensitivity / Q000503:physiopathology / Q000517:prevention & control; D008297:Male; D015999:Multivariate Analysis; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D010919:Placebos; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D013997:Time Factors
D002090:Butyrophenones; D002214:Capsules; D006634:Histamine H1 Antagonists; D010880:Piperidines; D010919:Placebos; D006919:Hydroxyzine; D006632:Histamine; C058249:ebastine; D017332:Cetirizine