A subset of antibodies from the sera of patients with systemic lupus erythematosus react with vimentin and DNA.
Sera from patients with systemic lupus erythematosus were tested for the simultaneous presence of antibodies to intermediate filaments (vimentin) and to DNA, using radioimmunoassay and immunofluorescence techniques. Our results indicate that 3 of 17 sera tested contain an IgM population which recognizes an antigenic determinant common to vimentin and DNA by a solid phase immunoassay.
Centro de Biologia Molecular (CSIC-UAM) Universidad Autónoma, Madrid, Spain.
A
A
Sánchez
C
C
Ossorio
J M
JM
Alvaro-Gracia
R
R
Padilla
J
J
Avila
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D000939:Epitopes / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007382:Intermediate Filaments / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D014746:Vimentin / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D000939:Epitopes; D014746:Vimentin