Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic.
The birth dates of schizophrenic inpatients in eight health regions in England and Wales were reviewed for any effect of the 1957 A2 influenza epidemic. 5 months after the peak infection prevalence, the number of births of individuals who later developed schizophrenia was 88% higher than the average number of such births in the corresponding periods of the 2 previous and the next 2 years. This finding is in accordance with a study from Helsinki and with clinical and neuropathological evidence of aberrant fetal brain development in the pathogenesis of schizophrenia.
O'Callaghan
E
E
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Sham
P
P
Takei
N
N
Glover
G
G
Murray
R M
RM
D000328:Adult; D004196:Disease Outbreaks; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000150:complications* / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D012559:Schizophrenia / Q000209:etiology*; D014852:Wales / Q000453:epidemiology