[Stimulation of mucous glands of the respiratory tract by neuropeptides: comparison of exogenous administration and endogenous liberation].
Exogenous substance P is a powerful stimulant of tracheal gland secretion but the contribution of endogenous neuropeptides to neurogenic gland secretion is unknown. Using the Ussing chamber technique, we measured the secretion of radiolabeled macromolecules from submucosal glands in the ferret. Neurokinins caused gland secretion through a neurokinin-1 (NK-1) receptor. Gland secretion caused by electric field stimulation of postganglionic nerve endings was not inhibited by a substance P antagonist and was not augmented by agents known to prevent neurokinin degradation in the tissue. We conclude that the release of endogenous neurokinins plays no rôle in neurally evoked gland secretion. This is despite the fact that endogenous neurokinins have been shown to be involved in vagally induced airway smooth muscle contraction and increased capillary permeability in the same species.
Medizinische Poliklinik der Universität, Würzburg.
H L
HL
Hahn
B
B
Hümmer
A
A
Freyer-Barski
S
S
Bleicher
D000818:Animals; D005088:Exocrine Glands / Q000294:innervation*; D005260:Female; D005289:Ferrets; D008297:Male; D009093:Mucus / Q000378:metabolism*; D015288:Neurokinin A / Q000502:physiology*; D015287:Neurokinin B / Q000502:physiology*; D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter / Q000502:physiology; D013373:Substance P / Q000502:physiology*; D014132:Trachea / Q000294:innervation*
D018041:Receptors, Neurokinin-2; D017981:Receptors, Neurotransmitter; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B
Stimulierung von Schleimdrüsen der Atemwege durch Neuropeptide: Vergleich exogener Zufuhr und endogener Freisetzung.