Inhibition of in vitro RNA synthesis by hycanthone, oxamniquine and praziquantel.
The schistosomicides, hycanthone, oxamniquine and praziquantel, were found to inhibit the in vitro RNA synthesis using isolated hamster liver nuclei. Preincubation of the nuclei with these drugs revealed that the inhibitory effect of oxamniquine was irreversible and progressed with time, whereas that of hycanthone and praziquantel was reversible. On the other hand, hycanthone and praziquantel have a high affinity for DNA but oxamniquine does not. The data indicate that the mechanism of inhibition by oxamniquine is different from that of hycanthone and praziquantel.
Department of Biological Sciences, University of Lowell, Massachusetts 01854.
L J
LJ
Wong
G C
GC
Tsao
J I
JI
Bruce
S S
SS
Wong
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D004247:DNA / Q000378:metabolism; D003864:Depression, Chemical; D006826:Hycanthone / Q000378:metabolism / Q000494:pharmacology*; D008099:Liver / Q000166:cytology; D009600:Nitroquinolines / Q000494:pharmacology*; D010073:Oxamniquine / Q000378:metabolism / Q000494:pharmacology*; D011223:Praziquantel / Q000378:metabolism / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis*; D013892:Thioxanthenes / Q000494:pharmacology*
D009600:Nitroquinolines; D013892:Thioxanthenes; D010073:Oxamniquine; D006826:Hycanthone; D012313:RNA; D011223:Praziquantel; D004247:DNA