DNA-RFLP analysis and genotyping of HLA-DR alleles in the south of Spain.
42 healthy individuals previously HLA-DR typed by serology, were HLA class II typed using RFLPs. The pattern of hybridization revealed allele specific DNA fragments for some DR specificities. Three fragments highly associated with HLA-DR antigens: a 7 kb RFLP with DR1; a 10 kb RFLP with DR-3/DR-5 and a 13 kb band with DR4/DR7.
Servicio Análisis Clínicos e Inmunología, Hospital Virgen de las Nieves, Universidad de Granada, España.
J
J
Martín
D
D
Almeida
M J
MJ
Mialdea
M
M
Rodriguez
L
L
Mataran
F
F
Garrido
D000483:Alleles; D004247:DNA / Q000235:genetics; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D013030:Spain
D006684:HLA-DR Antigens; D004247:DNA