Influence of hydrocortisone acetate on pancreas and mucosal weight, amylase and disaccharidase activities in 14-day-old pigs.
1. One litter of 12 pigs was used to evaluate the effects of hydrocortisone acetate injection on organ weight and carbohydrase activities. 2. Pigs were injected with hydrocortisone acetate or an equal volume of saline at 7 days of age and killed at 14 days, and tissues were collected, weighted, and analyzed for carbohydrase activities. 3. Hydrocortisone had no effect (P greater than 0.40) on daily gain, liver weight, spleen weight, or small intestinal length. 4. Hydrocortisone increased pancreatic weight by 29% and total pancreatic alpha-amylase content by 38%. 5. Hydrocortisone increased duodenal mucosal weight by 23%, duodenal lactase activity by 44%, duodenal maltase activity by 163%, and duodenal sucrase activity by 214%.
Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506.
K K
KK
Kreikemeier
D L
DL
Harmon
J L
JL
Nelssen
D000681:Amylases / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004186:Disaccharidases / Q000378:metabolism; D004386:Duodenum / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology; D005260:Female; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000033:anatomy & histology / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000033:anatomy & histology / Q000187:drug effects* / Q000201:enzymology; D013552:Swine
C021650:hydrocortisone acetate; D000681:Amylases; D004186:Disaccharidases; D006854:Hydrocortisone