RGD-containing peptides of VP1 of foot-and-mouth disease virus (FMDV) prevent virus infection in vitro.
RGD-containing peptides from the immunodominant region of VP1 between amino acids 135-160 from foot-and-mouth disease virus (FMDV) type O1 Kaufbeuren (O1K) prevented virus adsorption to piglet kidney (PK) cells. The highly conserved amino acid RGD sequence (Arg.-Gly.-Asp.) was a prerequisite of this effect. To prevent infection with 100-200 TCID50 in 10(6) PK cells, 20-250 micrograms of each peptide should have been added.
Friedrich-Loeffler-Institut, Inself Riems, Fed. Rep. Germany.
H
H
Liebermann
R
R
Dölling
D
D
Schmidt
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G
Thalmann
D000327:Adsorption; D000595:Amino Acid Sequence; D000818:Animals; D005537:Aphthovirus / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D002213:Capsid / Q000276:immunology / Q000494:pharmacology*; D036022:Capsid Proteins; D002478:Cells, Cultured; D016056:Immunodominant Epitopes / Q000276:immunology; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000276:immunology / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011991:Receptors, Virus / Q000187:drug effects*; D013552:Swine
D036022:Capsid Proteins; D016056:Immunodominant Epitopes; D009842:Oligopeptides; D010446:Peptide Fragments; D011991:Receptors, Virus; C442501:VP1 protein, Foot-and-mouth disease virus; C047981:arginyl-glycyl-aspartic acid