Early diagnosis of esophageal cancer.
The doubling time of esophageal cancer, as measured by x-ray films, was studied retrospectively. The average doubling time of 19 lesions in 18 cases was 6.7 months, but in three cases the lesions doubled within a month. The developing time of depth of invasion in esophageal cancer in 19 lesions were: from mucosa to submucosa, 16 +/- 7.8 months; submucosa to advanced adventitia, 6.6 +/- 3.8 months; mucosa to advanced adventitia, 21.1 +/- 6.8 months. Lugol-staining endoscopy was effective in detecting not only lesions but also margin lines. Capsulated brushing cytology is also effective and the diagnostic rate was 94.5% in total, and 84.4% in superficial cancer. For early detection of esophageal cancer it is most desirable to have examinations once every six months and a combination of these three methods is recommended.
Second Department of Surgery, Kyorin University School of Medicine, Tokyo, Japan.
K
K
Nabeya
T
T
Hanaoka
K
K
Onozawa
S
S
Ri
T
T
Nyumura
C
C
Kaku
D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D013194:Staining and Labeling; D013997:Time Factors