Effects of clofibrate on basal and insulin-activated glucose uptake in fast and slow skeletal muscles of rats.
1. The basal uptake of glucose was increased significantly in the extensor digitorum longus muscle (EDL) of rats by clofibrate administration. 2. The insulin-activated uptake of glucose was increased in the soleus muscle (Sol) by clofibrate. 3. The insulin-induced increment of glucose uptake was increased significantly in Sol and decreased significantly in EDL by clofibrate.
Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
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Shoji
D000818:Animals; D001835:Body Weight; D002994:Clofibrate / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D002994:Clofibrate; D005947:Glucose