[Alterations of Lewis related sugar antigens in gastric atypical epithelial lesions (adenomas or dysplasia) with relation to their malignant changes--an evaluation by follow-up cases].
Alterations of carbohydrate chain antigens were investigated immunohistochemical in relation to histological malignant changes on 62 cases of gastric atypical epithelial lesions (adenomas) which were diagnosed as Group-III at the first biopsy and then followed up more than one year. Among 7 carbohydrate chain antigens which are related to Lewis antigens, sialyl Lex-i antigen showed the most impressive findings; The positivity percentage of the first biopsy specimens of Group-III was 6%, however, it raised to 33% in the final biopsy specimens of Group-IV, 50% in the resected specimens of border-line lesions, and 67% in the resected specimens of carcinomas. The results indicate that there exists a close correlation between malignant change of gastric atypical epithelial lesions and alteration of carbohydrate chain in terms of sialylation.
Second Department of Pathology, Kagoshima University, Faculty of Medicine.
H
H
Horinouchi
E
E
Sato
S
S
Yonezawa
S
S
Tanaka
D000236:Adenoma / Q000276:immunology* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D002277:Carcinoma / Q000276:immunology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D016256:Lewis X Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology
D015295:Antigens, Tumor-Associated, Carbohydrate; D016256:Lewis X Antigen