Effect of FK-506 and cyclosporine on human T and B lymphoproliferative responses.
The macrolide antibiotic FK-506 causes a strong inhibition of human T and B cell proliferation in vitro in concentrations 100-fold lower than cyclosporine (CsA). However, B cell activation appears to be less sensitive to the immunosuppressive action of FK-506 than T cell responses. There was no indication of a synergistic interaction of the two agents. In contrast, CsA added together with FK could counteract the immunosuppressive activity of the latter drug.
Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
M
M
Wasik
B
B
Stepień-Sopniewska
Z
Z
Lagodziński
A
A
Górski
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D016559:Tacrolimus
D000900:Anti-Bacterial Agents; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D016559:Tacrolimus