Furosemide kinetics and dynamics in rats and humans.
1. Increasing doses of furosemide (F) were given intravenously to rats and humans and initial pharmacokinetics and pharmacodynamics were compared. 2. Weight-related initial renal excretion rate of F was twice as high in rats and serum concentration at 30 min was twice as high in humans (P less than 0.01). 3. Volume of distribution for F was 44% larger in rats (P less than 0.01). 4. Maximal weight-related diuretic and natriuretic responses were, like the theoretical maximal efficiency, 5-6 times higher in the rat. The potency was 230 times lower in the rats. 5. On a molecular basis species differences in kinetics disappeared when standardization was based on ERPF and species differences in dynamics disappeared when standardization was based on GFR.
Andreasen
F
F
Division of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Denmark.
Tietze
I
I
Hansen
F A
FA
Petersen
J S
JS
Christensen
S
S
Steiness
E
E
D000818:Animals; D001835:Body Weight / Q000502:physiology; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005665:Furosemide / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D009318:Natriuresis / Q000187:drug effects; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D005665:Furosemide