Sulphasalazine-induced reversible hypersensitivity pneumonitis and fatal fibrosing alveolitis: report of two cases.
The cases of two patients with ulcerative colitis are described who developed pulmonary infiltrates during the early months of treatment with sulphasalazine. The first patient had a hypersensitivity pneumonitis, which was confirmed by challenge. Recovery was complete. The second patient developed a fibrosing alveolitis type reaction, with fatal outcome.
Leino
R
R
Department of Medicine, Turku University, Finland.
Liippo
K
K
Ekfors
T
T
D000328:Adult; D000542:Alveolitis, Extrinsic Allergic / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D012460:Sulfasalazine / Q000009:adverse effects*
D012460:Sulfasalazine