Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver.
Transcription of the mouse alpha-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the alpha-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.
Howard Hughes Medical Institute, Department of Biology, Princeton University, NJ 08544.
J
J
Vacher
S M
SM
Tilghman
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D005333:Fetus; D005786:Gene Expression Regulation; D051537:Hepatocyte Nuclear Factor 1; D051538:Hepatocyte Nuclear Factor 1-alpha; D051539:Hepatocyte Nuclear Factor 1-beta; D008099:Liver / Q000254:growth & development / Q000378:metabolism*; D051379:Mice; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D000509:alpha-Fetoproteins / Q000235:genetics*
D004268:DNA-Binding Proteins; D051538:Hepatocyte Nuclear Factor 1-alpha; C496488:Hnf1a protein, mouse; C496496:Hnf1b protein, mouse; D009687:Nuclear Proteins; D014157:Transcription Factors; D000509:alpha-Fetoproteins; D051537:Hepatocyte Nuclear Factor 1; D051539:Hepatocyte Nuclear Factor 1-beta