Cytomegalovirus and human herpesvirus-6 in sudden infant death syndrome: an in situ hybridization study.
Thirty lung, spleen, and thymus sections and four lymph node sections from 40 sudden infant death syndrome (SIDS) cases were probed with biotinylated DNA probes specific for human herpesvirus-6 (HHV-6) and cytomegalovirus (CMV). Control material gave a strong, distinct signal with little or no background staining and no cross-reactivity. No staining was found with the SIDS material. We find no evidence to implicate an overwhelming infection by either virus in SIDS.
Department of Morbid Anatomy, London Hospital Medical College, England.
A
A
Coumbe
J D
JD
Fox
M
M
Briggs
R S
RS
Tedder
C L
CL
Berry
D003586:Cytomegalovirus Infections / Q000150:complications*; D004247:DNA; D006566:Herpesviridae Infections / Q000150:complications*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008168:Lung / Q000382:microbiology; D008221:Lymphoid Tissue / Q000382:microbiology; D009693:Nucleic Acid Hybridization; D013194:Staining and Labeling; D013398:Sudden Infant Death / Q000209:etiology*
D004247:DNA