Long-lasting effects of audiogenic seizures on neurotransmitter amino acids in Rb mice.
The existence of long-lasting (15-18 h) alterations of neurotransmitter amino acid levels following a single or repeated acoustic stimulations in audiogenic seizure-prone Rb1 and Rb2 mice and seizure-resistant Rb3 mice were investigated. The levels of glutamate, aspartate, glycine, taurine, and of some of their precursors: glutamine and serine were determined. Fourteen brain areas were examined. Alterations were found only in 6 brain areas (pons, olfactory bulbs, superior colliculus, inferior colliculus, olfactory tubercles and raphe). Most frequent occurring changes were observed in pons and olfactory tubercles. These changes concerned mainly the excitatory amino acids, glutamate, and aspartate. Alterations of taurine, glycine and serine were also recorded.
Centre de Neurochimie du CNRS, Strasbourg, France.
S
S
Simler
L
L
Ciesielski
J
J
Clement
A
A
Rastegar
P
P
Mandel
D000161:Acoustic Stimulation; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004198:Disease Susceptibility; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012640:Seizures / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors
D000596:Amino Acids; D018377:Neurotransmitter Agents