Cutaneous reactions to substance P and histamine in atopic dermatitis.
The flare and weal reactions to intradermal injections of histamine and the peptide substance P were measured in a group of patients with atopic dermatitis and compared to reactions in a non-atopic control group. There was no significant difference in the flare areas between the controls and atopics with either reagent. The weal volumes after injection of substance P and histamine were significantly larger in the atopic group. As substance P causes mast cell histamine release, the increased weal volumes produced by substance P in the atopics may be entirely due to the exaggerated atopic weal reaction to histamine.
Skin Laboratory, St Helier Hospital, Carshalton, Surrey, U.K.
I H
IH
Coulson
C A
CA
Holden
D000328:Adult; D003876:Dermatitis, Atopic / Q000378:metabolism / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000096:biosynthesis / Q000494:pharmacology*; D006801:Humans; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D012867:Skin / Q000187:drug effects*; D013373:Substance P / Q000494:pharmacology*; D013997:Time Factors
D013373:Substance P; D006632:Histamine