A correlation study of CSF neuropeptides in Alzheimer's and Parkinson's disease.
The concentrations of somatostatin (SRIF), vasoactive intestinal polypeptide (VIP), beta-endorphin (beta-EP), adrenocorticotropin (ACTH) and corticotropin-releasing factor (CRF) immunoreactivity were measured in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD), patients with Parkinson's disease (PD) and controls. In order to study the mechanisms that regulate peptide levels in CSF and peptide interactions, correlations between CSF peptides were determined. Within all patient groups a number of significant correlations were shown to exist between CSF peptides. The correlations were apparently not coincidental, since there was no such relation between the concentrations of CSF peptides and CSF protein content. Neither age, sex, severity of dementia nor the presence of extrapyramidal signs could explain the number of significant correlations. These results indicate, that the correlations found between CSF peptides may be due to common regulatory mechanisms or general physiological behaviour of peptides in the CSF.
Vaajasalo Hospital, Kuopio, Finland.
J
J
Jolkkonen
P
P
Hartikainen
R
R
Soikkeli
G
G
Bissette
C
C
Nemeroff
P
P
Riekkinen
D000324:Adrenocorticotropic Hormone / Q000134:cerebrospinal fluid; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D003346:Corticotropin-Releasing Hormone / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D013004:Somatostatin / Q000134:cerebrospinal fluid; D014660:Vasoactive Intestinal Peptide / Q000134:cerebrospinal fluid; D001615:beta-Endorphin / Q000134:cerebrospinal fluid
D009479:Neuropeptides; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D001615:beta-Endorphin; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone