Influence of intravenous administration set composition on the sorption of isosorbide dinitrate.
The influence of the composition of administration sets on the sorption of isosorbide dinitrate was investigated in-vitro. Isosorbide dinitrate solutions (250 micrograms mL-1) in 0.9% NaCl or 10% glucose were stored in glass containers and administered at a flow rate of 20 mL h-1. The influence of the concentration of different plasticizers (di-ethylhexylphthalate, tri-ethylhexyltrimelitate) in polyvinylchloride tubings was determined. Polybutadiene tubings of different mol. wt coextruded laminates of these polybutadienes with PVC of different composition and a polyethylene tubing were evaluated. The higher the Shore hardness of the PVC tubing, the lower the sorption. The infusion fluid played an additional role only for the tubings with high Shore hardness (greater than 70). The sorption of isosorbide dinitrate to polybutadiene tubings of different mol. wt was less than 2.5% after 5 h and was comparable with the sorption to the polyethylene tubing. When polybutadiene/PVC laminates were used, the sorption increased significantly and was in most cases dependent on the Shore hardness of the PVC (higher Shore hardness gave lower sorptions) and on the mol. wt of the polybutadiene (lower mol. wt resulted in higher sorption). Sorption was not dependent on the type of PVC plasticizer.
Laboratory of Pharmaceutical Technology, State University of Gent, Belgium.
C
C
De Muynck
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F
Colardyn
J P
JP
Remon
D000327:Adsorption; D007262:Infusions, Intravenous / Q000295:instrumentation; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010968:Plasticizers
D010968:Plasticizers; D007548:Isosorbide Dinitrate