Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.
A 66-year-old pseudophakic man with primary open-angle glaucoma and ocular cicatricial pemphigoid underwent trabeculectomy and was given postoperative subconjunctival 5-fluorouracil. He developed an inferior corneal epithelial defect and, later, a well-demarcated area of inferior corneal keratinization. Since the corneal keratinization clinically improved with conservative management, surgical intervention was not required.
Phelan
M J
MJ
W.K. Kellogg Eye Center, Department of Ophthalmology, University of Michigan, Ann Arbor 48105-7594.
Skuta
G L
GL
D000368:Aged; D003228:Conjunctiva / Q000378:metabolism; D003316:Corneal Diseases / Q000188:drug therapy / Q000209:etiology*; D005472:Fluorouracil / Q000009:adverse effects*; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007633:Keratins; D008297:Male; D009824:Ointments / Q000627:therapeutic use; D010390:Pemphigoid, Benign Mucous Membrane / Q000150:complications / Q000175:diagnosis; D012086:Reoperation; D014130:Trabeculectomy / Q000009:adverse effects*
D009824:Ointments; D007633:Keratins; D005472:Fluorouracil