'Flagellate' erythema from bleomycin. With histopathological findings suggestive of inflammatory oncotaxis.
A case of erythema in a 'flagellate' pattern due to administration of bleomycin in a patient with Hodgkin's disease is described. Emphasis is placed on the low dose of bleomycin administered--15 mg parenterally--and the short time interval between drug administration and beginning of symptoms: 24 h. The histopathological findings were consistent with a mechanism of inflammatory oncotaxis: the attraction of tumor cells by the skin perhaps due to the bleomycin accumulated and the trauma caused by scratching subsequent to pruritus.
Cortina
P
P
Departamento de Dermatologia, Hospital General Universitario, Salamanca, España.
Garrido
J A
JA
Tomas
J F
JF
Unamuno
P
P
Armijo
M
M
D000328:Adult; D001706:Biopsy; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004890:Erythema / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans
D001761:Bleomycin