[The role of tissue basophils in the regulation of the secretory activity of macrophages].
Mast cells and macrophages isolated from sensitized rats are unequivalent producer of enzymes in systems in vitro. Allergen intensifies exocytosis of acid phosphatase in them but the activity of allergen-induced enzyme secretion by macrophages ++ in immunized rats is lower than the activity of spontaneous secretion of acid phosphatase in suspensions of macrophages + in nonimmunized rats. Macrophages rather than mast cells show the ability for exocytosis of C4-gamma-glutamyltranspeptidase, leukotriene++ catabolism enzyme. Cocultivation of immune macrophages with syngeneic mast cells in the presence of allergen is followed with sharp depression of the activity of this enzyme secretion, that can create conditions for prolongation of eicosanoid effects in allergy.
Iu K
IuK
Bashmakov
T V
TV
Sidorenko
L A
LA
Diugovskaia
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D066298:In Vitro Techniques; D008264:Macrophages / Q000201:enzymology*; D008407:Mast Cells / Q000502:physiology*; D010529:Peritoneal Cavity / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D005723:gamma-Glutamyltransferase; D000135:Acid Phosphatase
Rol' tkanevykh bazofilov v reguliatsii sekretornoĭ aktivnosti makrofagotsitov.