Influence of azelastine on IL-1 beta generation in vitro and IL-1 beta-induced effect in vivo.
The effects of the novel antiasthmatic/antiallergic compound azelastine on IL-1 beta were investigated in vitro and in vivo. In leukocytes both, intra- and extracellular IL-1 generation stimulated by LPS was inhibited dose dependently. In contrast azelastine did not prevent IL-1 beta-induced immigration of PMNs into the mouse ear. These findings suggest that azelastine is not an IL-1 antagonist but inhibits IL-1 synthesis and/or release in leukocytes.
Department of Pharmacology, ASTA Pharma AG, Frankfurt/Main, FRG.
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U
Werner
J
J
Schmidt
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I
Szelenyi
D000328:Adult; D000818:Animals; D015415:Biomarkers; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000139:chemically induced* / Q000201:enzymology / Q000473:pathology; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D010793:Phthalazines / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
D015415:Biomarkers; D006634:Histamine H1 Antagonists; D007375:Interleukin-1; D010793:Phthalazines; D011994:Recombinant Proteins; D009195:Peroxidase; C020976:azelastine