The gene encoding peripheral myelin protein zero is located on mouse chromosome 1.
We have used somatic cell hybrids to map the gene encoding protein zero (P0), the major structural protein of peripheral myelin. Analysis of Southern blots of DNA obtained from these hybrids allows us to unambiguously assign the P0 gene to mouse chromosome 1. This observation indicates that mutations in the P0 gene do not account for Trembler, a chromosome 11 mutation that specifically affects myelination in the peripheral nervous system.
Molecular Neurobiology Laboratory, Salk Institute, San Diego, California 92138.
R
R
Kuhn
D
D
Pravtcheva
F
F
Ruddle
G
G
Lemke
D000818:Animals; D015139:Blotting, Southern; D002460:Cell Line; D002874:Chromosome Mapping; D006224:Cricetinae / Q000235:genetics; D006822:Hybrid Cells; D051379:Mice / Q000235:genetics*; D018993:Myelin P0 Protein; D009185:Myelin Proteins / Q000235:genetics*
D018993:Myelin P0 Protein; D009185:Myelin Proteins