Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation.
Transforming growth factor beta 1 (TGF beta 1) has been shown to have multiple effects on primary cultures of palate-derived cell types. We report the analysis, by in situ hybridization, of RNA expression for three different TGF beta isoforms (TGF beta 1, beta 2, and beta 3) during murine embryonic palate development. Differential expression of the three TGF beta genes is seen in the palatal shelves in mesenchymal and epithelial cells known to be involved in the morphogenesis of this organ. Taken together, these results suggest that the TGF beta s act as endogenous factors involved in the formation of the mammalian palate.
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232.
R W
RW
Pelton
B L
BL
Hogan
D A
DA
Miller
H L
HL
Moses
D000818:Animals; D005314:Embryonic and Fetal Development; D005260:Female; D005786:Gene Expression Regulation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009693:Nucleic Acid Hybridization; D010159:Palate / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D011247:Pregnancy; D012313:RNA / Q000032:analysis / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics*
D016212:Transforming Growth Factor beta; D012313:RNA