Clinical significance of antibodies to a 68 kDa U1RNP polypeptide in connective tissue disease.
In a series of 163 patients with systemic lupus erythematosus (SLE) and/or systemic sclerosis and/or mixed connective tissue disease (MCTD), the presence of antibodies to a 68 kDa U1RNP associated polypeptide was more predictive for SLE (88%) than for MCTD (38-68%) using 3 different sets of proposed criteria for the latter condition. In all but one case studied serially the immunoblotting profile remained constant. In SLE recognition of the 68 kDa polypeptide identified a subset with increased vasoreactivity with Raynaud's phenomenon (96%, p less than 0.001) and swollen fingers (68%, p less than 0.001) whereas recognition of a 47 kDa La (SSB) polypeptide was associated with photosensitivity (72%, p less than 0.02), less renal involvement (p less than 0.05) and an older age of disease onset (46.6 years +/- 18.3 SD, p less than 0.002).
Royal National Hospital for Rheumatic Diseases, Bath, England.
N
N
McHugh
I
I
James
P
P
Maddison
D000906:Antibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D003240:Connective Tissue Diseases / Q000276:immunology*; D000939:Epitopes; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000032:analysis; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000276:immunology; D010455:Peptides / Q000276:immunology; D012595:Scleroderma, Systemic / Q000097:blood / Q000276:immunology; D055517:snRNP Core Proteins
D000906:Antibodies; D001324:Autoantigens; D000939:Epitopes; D007106:Immune Sera; D007132:Immunoglobulin Isotypes; D010455:Peptides; D055517:snRNP Core Proteins