[The inhibitory effect of disodium cromoglycate on substance P sensory nerve fibres].
Electrical field stimulation of sensitized guinea pig hilus bronchi induced a long lasting contractile response which was insensitive to atropine, but could be antagonized by a substance P (SP) antagonist. Antigen challenge of sensitized guinea pig main and hilus bronchi evoked a double-phase contractile response which consisted of a rapid contraction and a slow contraction. Both of them were sensitive to SP-antagonist, especially its slow contraction. Disodium cromoglycate (DSCG) inhibited the contractile responses induced by electrical field stimulation and antigen challenge. significantly. These results suggest that DSCG has inhibitory effect on the release of SP sensory nerve fibre endings induced by some stimulators, which might be related to the effect of DSCG against asthma.
Department of Pharmacology, Shanghai Medical University.
J
J
Li
Y H
YH
Chu
D000818:Animals; D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects; D004205:Cromolyn Sodium / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects; D011984:Sensory Receptor Cells / Q000187:drug effects*; D013373:Substance P / Q000378:metabolism*
D013373:Substance P; D004205:Cromolyn Sodium