Proteinase inhibitors, kinins and the inflammatory reaction induced by sponge implantation in rats.
We studied the influence of aprotinin and soya bean trypsin inhibitor (SBTI) on the inflammatory reaction induced by the implantation of dry sponges in normal Wistar rats and in kininogen-deficient Brown Norway rats, during the first day after the implantation. In normal rats, aprotinin reduced the volume and total protein content of the exudates at 3 h but not thereafter. Aprotinin also markedly reduced the immunoreactive kinins and kallikrein in the exudates. Aprotinin did not modify the volume of the exudates of the Brown Norway rats. SBTI reduced the inflammatory reaction in both rat strains but did not significantly modify the formation of immunoreactive kinins. The inflammatory reaction developed more slowly in Brown Norway rats. The kinin system is thus involved during the first hours of the development of this acute inflammatory reaction. The anti-inflammatory effect of SBTI does not depend on the inhibition of kinin formation.
Damas
J
J
Physiologie Humaine, Université de Liège, Belgium.
Bourdon
V
V
Remacle-Volon
G
G
Adam
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007611:Aprotinin / Q000494:pharmacology; D005122:Exudates and Transudates / Q000201:enzymology / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced* / Q000503:physiopathology; D007704:Kininogens / Q000172:deficiency; D007705:Kinins / Q000494:pharmacology*; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007704:Kininogens; D007705:Kinins; D011480:Protease Inhibitors; D007611:Aprotinin