[Relationship between facilitatory effect of piracetam on memory and glutamate receptors].
By Y-maze method, repeated administrations of sodium glutamate 400 mg.kg-1.d-1 ip for 5 d before training remarkably reduced the number of trials from 45.3 +/- 15.5 of the control to 20.0 +/- 6.9 in mouse of anisodine-induced memory impairment. Ketamine (10 mg.kg-1, ip), a selective NMDA receptor antagonist, inhibited the anti-amnesic activity of piracetam. The number of memory errors was raised from 1.9 +/- 1.5 to 2.6 +/- 2.1 in mouse step-down test. Piracetam 500 mg.kg-1.d-1 ip for 3 d caused a decrease in mouse brain glutamate content and glutamate/GABA rate from 7.07 +/- 0.83 mumol.g-1 to 5.69 +/- 0.60 mumol.g-1 and 4.98 +/- 0.63 to 4.52 +/- 0.81, respectively. These results suggest that facilitatory effect of piracetam on memory may be mediated by glutamate receptor.
Zhang
L H
LH
Department of Pharmacology, Wenzhou Medical College, China.
Zhang
S S
SS
D000818:Animals; D001921:Brain / Q000378:metabolism; D004193:Discrimination Learning / Q000187:drug effects; D005260:Female; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D010889:Piracetam / Q000494:pharmacology*; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D017470:Receptors, Glutamate; D017981:Receptors, Neurotransmitter; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D007649:Ketamine; D010889:Piracetam