[The multifunctionality of regulatory peptides and the rule of "what--where--when" as a principle of their ordered action].
Consistent study of stages and history of discovery of regulatory peptides (RP) as a new class of multifunctional endogenic regulators puts forward some actual problems. A question what new notions on the manner of control of physiological functions have been introduced by RP investigation is considered. Two historical tendencies in the RP studies are estimated. A conception on peptides as multifunctional and colocated factors of neurohumoral regulation of organism was opposed to the idea of "single" substance--a regulator of "unique" function. In this connection a conception of peptide-regulatory continuum is considered and the author postulated the principle "what--where--when" as the main rule of RP well-regulated action. The statement on tissue (regional) specificity of the biogenesis processes of different RP as molecular basis of their regulatory function is grounded.
Gomazkov
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OA
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000502:physiology; D009479:Neuropeptides / Q000145:classification / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology; D013329:Structure-Activity Relationship
D009479:Neuropeptides; D018377:Neurotransmitter Agents
Polifunktsional'nost' reguliatornykh peptidov i pravilo "chto--gde--kogda" kak printsip ikh uporiadochennogo deĭstviia.