[The mechanism of the proaggregant action on the thrombocytes of RNA and DNA molecules].
The entrance of extracellular Ca2+ in ADP-stimulated human platelets and phospholipase A2 activity have been studied under the action of Ca precipitates DNA, RNA and dsRNA. The nucleic acids and its Ca complexes (Ca-NA) have been found to induce the aggregation of isolated human platelets by stimulation of extracellular Ca2+ entrance into the platelets and the formation of phosphatidilcholine and phosphatidilethanolamine lysoderivatives having the membranolytic effect.
R A
RA
Zakharian
L A
LA
Rukhkian
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000097:blood; D004247:DNA / Q000494:pharmacology*; D011464:Epoprostenol / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D012313:RNA / Q000494:pharmacology*; D012330:RNA, Double-Stranded / Q000494:pharmacology; D012331:RNA, Fungal / Q000494:pharmacology; D013268:Stimulation, Chemical; D014700:Verapamil / Q000494:pharmacology
D012330:RNA, Double-Stranded; D012331:RNA, Fungal; D000244:Adenosine Diphosphate; D012313:RNA; D004247:DNA; D014700:Verapamil; D011464:Epoprostenol; D002118:Calcium
K mekhanizmu proagregatnogo deĭstviia na trombotsity molekul RNK i DNK.