[A case of remission in metastatic lung tumor from hepatocellular carcinoma after combined CDDP and PSK therapy].
Discussed is the case of a 71-year-old man with multiple large hepatocellular carcinomas. His serum AFP level had markedly increased to 115 X 10(4) ng/ml. His AFP level also elevated and multiple lung metastatic tumors appeared after the second TAE therapy of 30 mg ADM, 10 mg MMC. To arrest these rises 100 mg of CDDP was given intravenously, followed by 3.0 g/day of PSK given orally. Five months later, shadows of the metastatic tumor disappeared and AFP to 540 ng/dl. As the mechanism responsible this improvement, it is felt that the CDDP attacked the metastatic tumors directly, and that this was aided by the follow-up immunotherapy with PSK. The abscopal effect of TAE also may have played a role.
Dept. of Int. Med., Yamaguchi Red Cross Hospital.
O
O
Miyanaga
M
M
Shirahama
H
H
Ishibashi
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000556:secondary / Q000628:therapy*; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000628:therapy*; D008297:Male; D011509:Proteoglycans / Q000627:therapeutic use*; D012074:Remission Induction; D000509:alpha-Fetoproteins / Q000032:analysis
D000276:Adjuvants, Immunologic; D011509:Proteoglycans; D000509:alpha-Fetoproteins; C010770:polysaccharide-K; D002945:Cisplatin