Frequency and prognostic importance of thrombocytopenia in symptom-free HIV-infected individuals: a 5-year prospective study.
The exact frequency of HIV-associated thrombocytopenia (TCP), defined as platelet count less than 150 x 10(9)/1, was studied in 435 symptom-free HIV-seropositive individuals. At the baseline control, 23 (5.5%) had TCP. TCP individuals had a significantly lower mean CD4 lymphocyte count than the non-TCP individuals. During a mean follow-up of 30 months, 79 out of the 435 individuals (18%) had TCP at least once. During the study period, only 1% of our patients had a platelet count less than 50 x 10(9)/l. TCP was more frequent in intravenous drug users than in other risk groups. A spontaneous normalization of platelet count was observed in more than 50% of TCP individuals.
Peltier
J Y
JY
Institut National de Transfusion Sanguine, Paris, France.
Lambin
P
P
Doinel
C
C
Couroucé
A M
AM
Rouger
P
P
Lefrére
J J
JJ
D000328:Adult; D015496:CD4-Positive T-Lymphocytes; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006679:HIV Seropositivity / Q000097:blood / Q000150:complications*; D015497:HIV-1; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D011446:Prospective Studies; D050378:T-Lymphocytes, Regulatory; D013921:Thrombocytopenia / Q000097:blood / Q000150:complications*