Common and dysplastic naevi as risk factors for cutaneous malignant melanoma in a Swedish population.
Common naevi, dysplastic naevi (DN) and other phenotypic features were evaluated as melanoma risk factors in a Swedish case-control study. One-hundred and twenty-one prevalent melanoma cases and 378 randomly selected controls participated. The mean total body naevus count was 115 in the cases and 67 in the controls. Fifty-six per cent of the cases and 18% of the controls had clinical DN. The corresponding figures for histologically diagnosed DN were 40% and 8% respectively. Clinical DN was as good as histologically diagnosed DN in identifying individuals at risk for melanoma. Subjects with sun-sensitive skin, greater than or equal to 150 naevi and presence of DN have 50 times higher melanoma risk than those without these characteristics.
Department of Dermatology, Sahlgrenska Hospital, Göteborg, Sweden.
A
A
Augustsson
U
U
Stierner
I
I
Rosdahl
M
M
Suurküla
D000328:Adult; D016022:Case-Control Studies; D004416:Dysplastic Nevus Syndrome / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D009506:Nevus / Q000150:complications* / Q000453:epidemiology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*; D013472:Sunlight / Q000009:adverse effects; D013548:Sweden / Q000453:epidemiology