Molecular differences between two immunologically related spumaretroviruses: the human prototype HSRV and the chimpanzee isolate SFV6.
A comparative study at the genomic and protein level was performed between two immunologically related spumaretroviruses, the human HSRV and the simian SFV6. Cross immunoprecipitation analysis with specific polyclonal and monoclonal antisera indicates shared antigenic determinants. However, restriction analysis of the viral DNAs and thermal stability of the hybrids demonstrate that HSRV and SFV6 are two different isolates.
Laboratoire des Rétrovirus et Rétrotransposons des Vertébrés, Hôpital Saint Louis, Paris, France.
J
J
Tobaly-Tapiero
M
M
Santillana-Hayat
M L
ML
Giron
M C
MC
Guillemin
F
F
Rozain
J
J
Périès
R
R
Emanoil-Ravier
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D015139:Blotting, Southern; D004279:DNA, Viral / Q000032:analysis; D000939:Epitopes; D005814:Genes, Viral; D006358:Hot Temperature; D006801:Humans; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes; D010455:Peptides / Q000032:analysis / Q000276:immunology; D011233:Precipitin Tests; D012190:Retroviridae / Q000145:classification / Q000235:genetics* / Q000276:immunology; D012191:Retroviridae Proteins / Q000032:analysis / Q000276:immunology; D016092:Spumavirus / Q000145:classification / Q000235:genetics / Q000276:immunology
D000956:Antigens, Viral; D004279:DNA, Viral; D000939:Epitopes; D010455:Peptides; D012191:Retroviridae Proteins