Genetic polymorphism of the murine myogenic gene Myo-D1.
Polymorphism of the myogenic gene, Myo-D1, has been sought to examine genetic mechanisms which control skeletal muscle development. By Southern analysis, three restriction-fragment length polymorphisms (RFLPs) have been found in various mouse strains using the TaqI, SacI and BglII restriction endonucleases and a full-length cDNA Myo-D1 probe. Reference to the distribution of RFLPs in different mouse strains derived from Mus mus (M.m.) domesticus and M.m. musculus subspecies suggests that Myo-D1 rearrangements are subject to nonrandom association. The biological significance of RFLP of the Myo-D1 gene is yet to be determined.
Kay
P H
PH
Department of Pathology, University of Western Australia, Nedlands.
Jacobsen
P F
PF
Zheng
M H
MH
Papadimitriou
J M
JM
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D004247:DNA / Q000032:analysis; D015321:Gene Rearrangement; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family; D017570:MyoD Protein; D009687:Nuclear Proteins / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D015534:Trans-Activators / Q000235:genetics*
D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D009687:Nuclear Proteins; D010750:Phosphoproteins; D015534:Trans-Activators; D004247:DNA