The negative inotropic effect of diazepam in rat right ventricular strips.
The effect of diazepam on cardiac contractility was investigated in electrically-driven right ventricular strips of the rat. Diazepam produced a concentration-dependent negative inotropic effect which was antagonized by either flumazenil, a benzodiazepine central-type receptor antagonist, or PK 11195, a benzodiazepine peripheral type receptor antagonist. The results suggest that the inhibitory effect of diazepam on cardiac contractility in the rat is mediated by both central and peripheral benzodiazepine receptors.
Hernández
J
J
Departamento de Fisiología y Farmacología, Facultad de Medicina, Espinardo-Murcia, Spain.
D000818:Animals; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D005442:Flumazenil / Q000494:pharmacology; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000187:drug effects
D007546:Isoquinolines; D011963:Receptors, GABA-A; D005442:Flumazenil; D003975:Diazepam; C037850:PK 11195