Griseolic acid, a cAMP phosphodiesterase inhibitor, and its ester: increase in cellular cAMP levels and reduction of intraocular pressure.
Yamazaki
M
M
Sankyo Co. Ltd., New Lead, Tokyo, Japan.
Yasumoto
T
T
Iijima
Y
Y
Yokoyama
T
T
Fukami
S
S
Kaneko
M
M
Kiuchi
Y
Y
Mishima
H
H
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002460:Cell Line; D000242:Cyclic AMP / Q000032:analysis*; D004952:Esters / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects; D007429:Intraocular Pressure / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D011817:Rabbits; D013329:Structure-Activity Relationship
D004952:Esters; C046499:griseolic acid; D000242:Cyclic AMP; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000241:Adenosine; D015056:1-Methyl-3-isobutylxanthine