The effects of an infusion of prostacyclin on their endotoxin shock in rabbits.
30 rabbits received an infusion of lipopolysaccharide B (75 micrograms/kg.h) over 4 hours (groups E, EI, EA; n = 10 each). Saline was given to a control group (C; n = 8). In group EI, prostacyclin (PGI2; 500 ng/kg.min) was given simultaneously to endotoxin. Into group EA animals, aspirin (20 mg/kg) was injected before the endotoxin infusion was started. PGI2 and aspirin both improved survival of animals (6/10 each vs. 2/10 in group E). The drop of platelet counts was significantly reduced by PGI2, while leukocyte depletion was similar in all endotoxin groups. PGI2 preserved the functional capacity of platelets as indicated by collagen stimulated aggregation and thromboxane formation. PGI2 but not aspirin significantly reduced renal fibrin deposition.
Department of Internal Medicine, Justus Liebig University, Giessen.
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Matthias
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Ditter
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D011464:Epoprostenol / Q000627:therapeutic use*; D005337:Fibrin / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D007958:Leukocyte Count; D010100:Oxygen / Q000097:blood; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation; D010976:Platelet Count; D011517:Prothrombin Time; D011817:Rabbits; D012772:Shock, Septic / Q000188:drug therapy*; D016019:Survival Analysis; D013929:Thromboxane B2 / Q000097:blood
D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D013929:Thromboxane B2; D005337:Fibrin; D005340:Fibrinogen; D011464:Epoprostenol; D001241:Aspirin; D010100:Oxygen