[Prospective studies of T4 and T8 lymphocyte subpopulations and beta 2-microglobulin in patients with HIV infection].
Sequential changes of percentage and number of T4 (helper) and T8 (cytotoxic/suppressor) lymphocyte subsets and serum beta 2 microglobulin (beta 2m) level were observed in 23 HIV infected patients for a period of 4 months to 3 years. 10 subjects were asymptomatic HIV carriers, 9 had already AIDS at the beginning of the study and 4 patients developed clinically overt disease during the observation period. T4 lymphocyte number remained in normal range in asymptomatic HIV carriers but in 4 patients its decrease preceded the development of clinical symptoms of infection. A rapid decrease of T4 lymphocyte number was generally observed in AIDS patients. Serum concentration of beta 2m remained at relatively low and constant level in asymptomatic HIV carriers but in 4 cases its increase preceded the appearance of clinical symptoms. In patients with clinically overt disease beta 2m levels were significantly increased and reached the highest values just before death. A correlation between clinical stage of infection and the number of T4 lymphocytes and beta 2 m level was found.
Zakład Immunopatologii, Instytut Chorób Zakaźnych i Pasozytniczych Akademii Medycznej w Warszawie.
M
M
Radkowski
T
T
Laskus
E
E
Kopicz-Kamińska
M
M
Mian
L
L
Babiuch
J
J
Slusarczyk
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology*; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002353:Carrier State / Q000097:blood / Q000276:immunology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008231:Lymphopenia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000473:pathology; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin
Prospektywne badania subpopulacji limfocytów T4 i T8 oraz beta-2-mikroglobuliny u osób zakazonych HIV.