Localization of arylsulphatase A and B activities in rat kidney.
Very high arylsulphatase activity has been detected in rat kidney. It is the highest in renal cortex (19 U/g tissue), 3-30 times higher than in other rat organs. Histochemically, arylsulphatase B (N-acetylgalactosamine-4-sulphate sulphatase) activity is localized in large lysosomes of proximal convoluted tubules, where it accounts for over 90% of total arylsulphatase activity. This suggests that the enzyme plays an important role in the degradation of endocytosed sulphated oligosaccharides.
Nicolaus Copernicus University, Department of Biochemistry, Toruń, Poland.
A J
AJ
Leźnicki
M
M
Rózańska
D000818:Animals; D002553:Cerebroside-Sulfatase / Q000378:metabolism*; D002803:Chondro-4-Sulfatase / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000166:cytology / Q000201:enzymology*; D007672:Kidney Cortex / Q000201:enzymology; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D002553:Cerebroside-Sulfatase; D002803:Chondro-4-Sulfatase