The prevention of cholelithiasis with infused sodium chenodeoxycholate in the prairie dog (Cynomys ludovicianus).
1. This study examines the efficacy of infused sodium chenodeoxycholate to prevent cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet. 2. Three experimental groups were designed to examine this. The first group (N = 5) was fed a normal rat chow diet, the second group (N = 5) was fed a high cholesterol diet (0.4% cholesterol by weight), and the third group (N = 5) was fed a high cholesterol diet plus given a daily injection of intravenous sodium chenodeoxycholate (15 mg/kg). 3. All of the animals in the second group had cholesterol crystals and cholesterol gallstones. In the third group, none of the animals had gallstones, and all but one lacked cholesterol crystals. 4. Statistical analysis showed that the first and third groups were statistically identical in their lithogenic indices and biliary lipid composition. 5. We concluded that infused sodium chenodeoxycholate is effective in preventing cholesterol gallstone formation in the prairie dog when fed a high cholesterol diet.
Broughton
G
G
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NB 68178.
Tseng
A
A
Fitzgibbons
R
R
Tyndall
S
S
Stanislav
G
G
Rongone
E L
EL
D000704:Analysis of Variance; D000818:Animals; D001646:Bile / Q000378:metabolism; D002635:Chenodeoxycholic Acid / Q000627:therapeutic use*; D002769:Cholelithiasis / Q000517:prevention & control*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D005704:Gallbladder / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D012589:Sciuridae
D002791:Cholesterol, Dietary; D002635:Chenodeoxycholic Acid