Chromosomal anomalies in cryptorchidism and hypospadias.
We have studied peripheral blood samples for chromosomal anomalies in 110 consecutive patients who had cryptorchidism and/or hypospadias. Of the patients 7 (6.4%) were found to have chromosomal anomalies. The incidence of chromosomal anomalies in patients with cryptorchidism only was 4/83 (4.8%), in patients with hypospadias only the incidence was 1/18 (5.6%) and in concomitant cases the incidence was 2/9 (22.2%). Of 69 patients with cryptorchidism and/or hypospadias who did not have any other congenital abnormalities, 3 patients (4.3%) were found to have sex chromosomal anomalies. However, of 41 patients associated with generalized congenital abnormalities including mental and growth retardation, we found 4 patients (9.8%) with autosomal anomalies. We conclude that most children with multiple associated abnormalities other than cryptorchidism and/or hypospadias should have chromosome analysis. Moreover, attention should be paid to sex chromosomal anomalies, even when patients with cryptorchidism and/or hypospadias do not have any associated generalized physical abnormalities.
Yamaguchi
T
T
Department of Urology, Miyazaki Medical College, Japan.
Kitada
S
S
Osada
Y
Y
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002891:Chromosomes, Human, Pair 21; D002897:Chromosomes, Human, Pair 7; D003456:Cryptorchidism / Q000150:complications / Q000235:genetics*; D006130:Growth Disorders / Q000150:complications / Q000235:genetics; D006801:Humans; D007021:Hypospadias / Q000150:complications / Q000235:genetics*; D007223:Infant; D008607:Intellectual Disability / Q000150:complications / Q000235:genetics; D007713:Klinefelter Syndrome; D008297:Male