Cell membrane changes in brains manifesting senile plaques: an immunohistochemical study of GM1 membranous ganglioside.
To investigate structural changes in cell membranes of the Alzheimer-type dementia (ATD) brain, we immunostained for GM1 ganglioside which is a major component of the cell membrane. Our results have shown that astrocytic membranes and senile plaques (SPs) have the same immunoreactivity against the monoclonal anti-ganglioside GM1 antibody. Moreover, the astrocytic processes within the SPs were altered and their abnormal membranes seemed to contribute to the formation of SPs.
Iwamoto
N
N
Department of Psychiatry, School of Medicine, Juntendo University, Tokyo, Japan.
Suzuki
Y
Y
Makino
Y
Y
Haga
C
C
Kosaka
K
K
Iizuka
R
R
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D001253:Astrocytes / Q000187:drug effects / Q000648:ultrastructure; D001921:Brain / Q000473:pathology*; D002462:Cell Membrane / Q000648:ultrastructure*; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D005677:G(M1) Ganglioside