Successful pregnancy after D-penicillamine therapy in a patient with Wilson's disease.
Infertility and amenorrhea are reported in most cases of Wilson's disease. In this report, we describe a case of Wilson's disease with pancytopenia and liver cirrhosis for over 4 years, without any specific treatment. After 2 years of D-penicillamine therapy, the patient became pregnant and delivered a liver mature female baby with a body weight of 2,800 g. Both before the pregnancy and after delivery, brainstem auditory evoked potential studies showed similar bilaterally abnormal prolongation in the III-V and I-V intervals. In visual evoked potentials, the P 100 latency was delayed bilaterally. Although serial evoked potential studies failed to show any improvement, a successful pregnancy was proven to be possible in a patient with Wilson's disease who had received regular D-penicillamine treatment.
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Taipei, Taiwan R.O.C.
Y K
YK
Soong
H Y
HY
Huang
C C
CC
Huang
N S
NS
Chu
D000328:Adult; D005260:Female; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D010396:Penicillamine / Q000627:therapeutic use*; D011247:Pregnancy
D010396:Penicillamine