Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.
Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.
Wellcome Research Laboratories, Beckenham, Kent, U.K.
R G
RG
Knowles
M
M
Merrett
M
M
Salter
S
S
Moncada
D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D004731:Endotoxins / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000166:cytology / Q000201:enzymology*; D008168:Lung / Q000201:enzymology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium
D004731:Endotoxins; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases