[The function of the peripheral adrenergic link under the action of neuroleptics in immobilization stress].
The morphofunctional state of different links of the sympathoadrenal system under the action of neuroleptics haloperidol and sulpiride was studied on the model of immobilization stress in rats. The drugs were shown to possess the effect of the pharmacological correction of hormone content in the adrenals and the level of the neuromediator activity of the adrenergic nerves at different stages of immobilization stress. The data obtained indicate the anti-stress action of the studied neuroleptics. The effect of sulpiride is noted both in the early (the stage of anxiety) and late (the stage of exhaustion) periods of immobilization. The action of haloperidol is mainly limited to the stage of anxiety.
E B
EB
Khaĭsman
V A
VA
Arefolov
L A
LA
Malikova
K S
KS
Raevskiĭ
D000313:Adrenal Medulla / Q000187:drug effects / Q000294:innervation; D000320:Adrenergic Fibers / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004388:Dura Mater / Q000187:drug effects; D006220:Haloperidol / Q000627:therapeutic use; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology; D013469:Sulpiride / Q000627:therapeutic use; D013997:Time Factors
D014150:Antipsychotic Agents; D013469:Sulpiride; D006220:Haloperidol
Sostoianie perifericheskogo adrenergicheskogo zvena pri deĭstvii neĭroleptikov v usloviiakh immobilizatsionnogo stressa.