A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.
A complex of polypeptides derived from a precursor is present on the surface of the malaria merozoite. During erythrocyte invasion only a small fragment from this complex is retained on the parasite surface and carried into the newly infected red cell. Antibodies to this fragment will interrupt invasion.
Division of Parasitology, National Institute for Medical Research, London, United Kingdom.
M J
MJ
Blackman
H G
HG
Heidrich
S
S
Donachie
J S
JS
McBride
A A
AA
Holder
D000818:Animals; D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology / Q000469:parasitology* / Q000648:ultrastructure; D006801:Humans; D008288:Malaria / Q000469:parasitology / Q000517:prevention & control; D010446:Peptide Fragments / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology* / Q000648:ultrastructure; D015800:Protozoan Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000939:Epitopes; D010446:Peptide Fragments; D015800:Protozoan Proteins