A placebo-controlled trial of nadolol in the treatment of neuroleptic-induced akathisia.
BACKGROUND
Although propranolol has been documented to be useful in treatment of neuroleptic-induced akathisia, preliminary anecdotal reports on the efficacy of nadolol in treatment of this condition are contradictory.


METHODS
To evaluate the efficacy of nadolol in treatment of this condition, a double-blind, placebo-controlled trial was conducted in 20 psychiatric inpatients. Patients with akathisia of at least moderate severity were randomly assigned to receive nadolol 40 to 80 mg/day or placebo. Patients were rated daily for 4 days, then every other day for 15 days by means of the Extrapyramidal Symptom Rating Scale.


RESULTS
No significant differences were found between or within groups in subjective restlessness scores. In objective akathisia scores, there were no significant differences between groups; however, beginning at Day 9, both groups showed significant improvement compared with Day 1. There was no difference between groups in number of responders.


CONCLUSIONS
The authors' data do not support the efficacy of nadolol in the treatment of neuroleptic-induced akathisia and do not provide support for a peripheral site of action for beta-blockers in treatment of this condition.
Department of Clinical Pharmacy, University of Tennessee, Memphis.
B G
BG
Wells
J A
JA
Cold
P A
PA
Marken
C S
CS
Brown
C C
CC
Chu
R P
RP
Johnson
C S
CS
Nasdahl
M A
MA
Ayubi
D H
DH
Knott
K L
KL
Arheart
D000293:Adolescent; D000328:Adult; D000368:Aged; D017109:Akathisia, Drug-Induced; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000139:chemically induced / Q000188:drug therapy; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009248:Nadolol / Q000008:administration & dosage / Q000627:therapeutic use*; D010919:Placebos; D011595:Psychomotor Agitation / Q000188:drug therapy*
D014150:Antipsychotic Agents; D010919:Placebos; D009248:Nadolol