Mast cells from human colonic mucosa and submucosa/muscle: a comparison with human lung mast cells.
The functional properties of enzymically dispersed mast cells from human lung parenchyma, colonic mucosa and colonic submucosa/muscle were compared. In general, the cells responded in a similar fashion to the histamine releasing action of a variety of immunological and non-immunological stimuli. However, some differences were observed in their responses to anti-allergic compounds. In total, these data indicate that there are subtle variations between human colonic and pulmonary mast cells but that these differences are much less sharply defined than in the rodent.
Department of Chemistry, University College London, UK.
W L
WL
Liu
L
L
Bosman
P B
PB
Boulos
H Y
HY
Lau
F L
FL
Pearce
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D003106:Colon / Q000166:cytology; D004205:Cromolyn Sodium / Q000494:pharmacology; D006633:Histamine Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000166:cytology*; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D009130:Muscle, Smooth / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D017835:Nedocromil; D015363:Quinolones / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006633:Histamine Antagonists; D015363:Quinolones; D017835:Nedocromil; D004205:Cromolyn Sodium