Commercial glucocorticoid formulations and skin dryness. Could it be caused by the vehicle?
Eczema craquelé can be induced by repeated open application of a topical glucocorticoid, viz. 0.05% clobetasole 17-propionate cream. This might not be invariably due to the active component. Comparison of the skin surface roughness as assessed by profilometry and as expressed by RZDIN showed a decrease after repeated open application of 0.1% betamethasone 17-valerate cream and 0.25% prednicarbate cream, but an increase following the vehicle of the latter preparation. Thus commercial oil-in-water emulsion preparations seem to be potentially injurious to human skin, though this may be masked when a glucocorticoid is added.
Department of Dermatology, Ludwig-Maximilians-Universität, Munich, Federal Republic of Germany.
H C
HC
Korting
M
M
Kerscher
D
D
Vieluf
L
L
Mehringer
M
M
Megele
O
O
Braun-Falco
D000279:Administration, Cutaneous; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004311:Double-Blind Method; D004485:Eczema / Q000139:chemically induced; D004643:Emollients / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005542:Forearm; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D014677:Pharmaceutical Vehicles / Q000009:adverse effects*; D012867:Skin / Q000473:pathology*
D000893:Anti-Inflammatory Agents; D004643:Emollients; D005938:Glucocorticoids; D014677:Pharmaceutical Vehicles