Management of severe hypertension in childhood Takayasu's arteritis.
Six children presented with severe hypertension caused by Takayasu's arteritis (TA), of whom four had bilateral renal artery narrowing and two coarctation syndrome. Two presented with hypertensive encephalopathy and four with congestive cardiac failure. All had a strongly positive skin reactions to purified protein derivative of mycobacterium tuberculosis. Bilateral renal arterial bypass grafts performed in two children resulted in prolonged normalization of their blood pressures, but the grafts clotted 12-18 months later. Primary renal autotransplantation was unsuccessful in two children, one with bilateral renal arterial narrowing and iliac vessel involvement and one with a long coarctation. Secondary renal autotransplantation was successful in a third child with localized aortitis. A successful aortic patch graft was performed in one child with coarctation of the aorta. Angiotensin-converting-enzyme inhibitors should be used with caution in treating the hypertension caused by TA, since bilateral renal arterial narrowing is common and their administration may result in renal insufficiency. The long-term prognosis is guarded in severely hypertensive children with extensive vascular disease due to TA.
Milner
L S
LS
Department of Pediatrics and Pediatric Surgery, Baragwanath Hospital, University of Witwatersrand, South Africa.
Jacobs
D W
DW
Thomson
P D
PD
Kala
U K
UK
Franklin
J
J
Beale
P
P
Levin
S E
SE
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000601:surgery*; D006977:Hypertension, Renal / Q000601:surgery; D008297:Male; D013625:Takayasu Arteritis / Q000150:complications* / Q000276:immunology