Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens.
RIIIS/J mice lack an autosomal dominant gene(s) that influences the magnitude of the antibody response to several polysaccharide antigens of bacterial origin. Low responsiveness is demonstrable whether polysaccharide is administered as a T-helper-cell-independent or -dependent antigen conjugated to an immunogenic carrier; however, RIIIS/J mice make good anti-hapten antibody responses to haptenated polysaccharides. The low antibody responses of RIIIS/J mice to type III pneumococcal polysaccharide do not appear to be the results of an imbalance in the activity of regulatory T lymphocytes. Compared with other strains of mice, RIIIS/J mice elicit low antibody responses to lipopolysaccharide (LPS). They do not develop a cyclic primary or secondary antibody response to Escherichia coli O113 LPS; the latter is not due to a lack of mitogenic response to E. coli O113 LPS. They also produce auto-anti-idiotypic antibody after being immunized with trinitrophenyl-Ficoll.
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Twinbrook II Research Facility, Rockville, Maryland 20852.
J R
JR
Hiernaux
P J
PJ
Baker
S J
SJ
McEvoy
P W
PW
Stashak
M B
MB
Fauntleroy
E A
EA
Goidl
D000818:Animals; D000917:Antibody Formation; D000943:Antigens, Differentiation / Q000032:analysis; D000950:Antigens, Ly / Q000032:analysis; D018956:CD5 Antigens; D003208:Concanavalin A / Q000494:pharmacology; D006241:Haptens; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007156:Immunologic Memory; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000943:Antigens, Differentiation; D000950:Antigens, Ly; D018956:CD5 Antigens; D006241:Haptens; D008070:Lipopolysaccharides; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D003208:Concanavalin A