Thyrotropin receptor antibody activities significantly correlate with the outcome of radioiodine (131I) therapy for hyperthyroid Graves' disease.
The outcome of 131I therapy for 109 patients with Graves' disease was analysed according to pretreatment laboratory data including thyrotropin receptor antibody (TRAb) activities. Forty-five percent of patients became euthyroid, and 13% of patients became hypothyroid within one year after 131I therapy. Forty-two percent of patients remained hyperthyroid one year after 131I therapy. Pretreatment values for serum T4, T3, and the estimated weight of the thyroid were significantly higher in the hyperthyroid group. The mean for the TRAb index of the hyperthyroid group was significantly higher than that of the euthyroid group. Life table analysis revealed a significant effect of the TRAb index on the rate of hyperthyroidism after 3 months or later. These results appear to suggest that the TRAb index is one of the factors which influence the outcome of 131I therapy for Graves' disease.
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
K
K
Kaise
N
N
Kaise
K
K
Yoshida
H
H
Fukazawa
K
K
Mori
M
M
Yamamoto
T
T
Sakurada
S
S
Saito
K
K
Yoshinaga
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006111:Graves Disease / Q000188:drug therapy*; D006801:Humans; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes / Q000494:pharmacology* / Q000627:therapeutic use; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D016896:Treatment Outcome; D014284:Triiodothyronine / Q000097:blood
D001323:Autoantibodies; D018828:Immunoglobulins, Thyroid-Stimulating; D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D013972:Thyrotropin