Acute pulmonary edema associated with use of low-molecular weight dextran for prevention of microvascular thrombosis.
Low-molecular weight dextran is commonly used to prevent thrombosis after microvascular procedures; however, the potential complications of this drug are not well known. We report a case of acute pulmonary edema in a healthy person after elective microsurgery for treatment of a malignant tumor of the forearm. The mechanism of action of dextran and the pathophysiology of two potential adverse reactions to this drug are discussed. It is thought that in this patient pulmonary edema was caused by dextran toxicity.
Kitziger
K J
KJ
Department of Orthopaedics, University of Texas Health Science Center, San Antonio.
Sanders
W E
WE
Andrews
C P
CP
D000208:Acute Disease; D003911:Dextrans / Q000009:adverse effects*; D005260:Female; D005542:Forearm / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D008970:Molecular Weight; D011654:Pulmonary Edema / Q000139:chemically induced*; D012509:Sarcoma / Q000601:surgery; D013927:Thrombosis / Q000517:prevention & control*
D003911:Dextrans