Transforming growth factors type beta inhibit multidrug transport in rat astrocyte cell lines.
Astrocytes--like some endothelial cells of the blood-brain barrier--can express a multidrug transport system, which limits the intracellular accumulation of cytostatic agents and a variety of other substances. I observed that astrocytic multidrug transport can be modulated by cytokines: The transforming growth factors type beta 1, beta 2, and beta 1,2 are specific inhibitors of multidrug transport in fetal rat brain astrocyte cell lines. Other cytokines or interleukins did not inhibit astrocytic multidrug transport. Interestingly, the inhibitory effect of TGF-beta could be antagonized by the bone morphogenetic protein BMP 2, a cytokine that is distantly related to TGF-beta.
Schluesener
H J
HJ
Department of Neurology, University of Wuerzburg, FRG.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000378:metabolism; D001692:Biological Transport; D019485:Bone Morphogenetic Proteins; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D004317:Doxorubicin / Q000493:pharmacokinetics; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors; D011506:Proteins / Q000494:pharmacology; D051381:Rats; D020112:Rhodamine 123; D012235:Rhodamines; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D014700:Verapamil / Q000493:pharmacokinetics; D014750:Vincristine / Q000493:pharmacokinetics
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D019485:Bone Morphogenetic Proteins; D008562:Membrane Glycoproteins; D011506:Proteins; D012235:Rhodamines; D016212:Transforming Growth Factor beta; D020112:Rhodamine 123; D014750:Vincristine; D004317:Doxorubicin; D014700:Verapamil