Loss of encephalitogenicity of a myelin basic protein-specific T cell line is associated with a phenotypic change but not with alteration in production of interleukin-2, gamma-interferon or tumour necrosis factor.
Continued stimulation of a CD4+ myelin basic protein-specific T cell line led to loss of in vivo encephalitogenic activity but no alteration in ability of the line to produce interleukin-2, gamma-interferon or tumour necrosis factor. Loss of encephalitogenicity was, however, associated with an increased presence of CD4+ CD8+ cells which likely represents preferential outgrowth of this population. The possible in vivo relevance of these findings is discussed.
Day
M J
MJ
MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, U.K.
Mason
D W
DW
D000818:Animals; D002460:Cell Line; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology*; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D010641:Phenotype; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D007376:Interleukin-2; D004676:Myelin Basic Protein; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma