[The vagus-inhibiting action of alpha-endorphin].
An intravenous bolus injection of 0.1 ml alpha-endorphin (1 x 10(-8)-1 x 10(-4) g/ml) didn't change the heart rate in frogs. The parasympathetic bradycardia induced by the peripheral vagus stimulation was decreased by alpha-endorphin. This vago-inhibitory action was dose-dependent (1 x 10(-5)-1 x 10(-4) g/ml). The maximal inhibitory action was watched in 4-8 and 9-15 minutes after bolus injection of alpha-endorphin in concentration of 1 x 10(-5) and 1 x 10(-4) g/ml accordingly.
Samonina
G E
GE
Karazeeva
E P
EP
D000818:Animals; D001919:Bradycardia / Q000209:etiology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004562:Electrocardiography; D004723:Endorphins / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D011898:Ranidae; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology; D018822:alpha-Endorphin
D004723:Endorphins; D018822:alpha-Endorphin
Vagoingibiruiushchee deĭstvie al'fa-éndorfina.