Role of exogenous interferons on intrinsic antiviral activity of macrophages from patients affected by neoplasia.
Macrophages derived from in vitro cultured monocytes were infected with herpes simplex virus type 2. A marked impairment in the intrinsic antiviral activity was found in macrophages obtained from patients with breast cancer or melanoma. Moreover, the antiviral activity of macrophages from healthy donors, differentiated in serum from patients with neoplasia, was also impaired. The aim of this work was the evaluation of alpha, beta, gamma exogenous interferon in restoring the intrinsic antiviral activity of macrophages from patients affected by breast cancer or melanoma under different conditions. Pretreatment of macrophages with alpha, beta interferons, but not gamma interferon, restored their impaired intrinsic antiviral activity.
Institute of Medical Microbiology, University of Messina, Italy.
R A
RA
Merendino
A
A
Arena
M C
MC
Liberto
M
M
Mesiti
S
S
Chillemi
D
D
Iannello
L
L
Bonina
D000368:Aged; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy / Q000209:etiology; D006564:Herpesviridae / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008545:Melanoma / Q000150:complications / Q000188:drug therapy; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy
D007370:Interferon Type I; D007371:Interferon-gamma; D007372:Interferons