Late changes in peripheral blood and spleen in mice after the effect of single whole body irradiation with the dose of 8 Gy.
Late haematopoietic changes were followed within 12-16 months after single whole body irradiation with the dose of 8 Gy. Permanently increased frequency of occurrence of cytopathologically altered leukocytes was observed in peripheral blood in irradiated animals as well as certain disorder of erythropoietic system. At the end of period followed the splenomegalia accompanied with marked macroscopic and microscopic changes was occurred. With simultaneous increase of occurrence of erythroblasts in peripheral blood the changes above are considered to be a symptom of erythroleukaemia.
Department of General Biology, Faculty of Science, P. J. Safarik, University Kosice, CSSR.
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Macková
D000818:Animals; D003037:Cobalt Radioisotopes; D004906:Erythrocyte Count / Q000528:radiation effects*; D004920:Erythropoiesis / Q000528:radiation effects*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000528:radiation effects*; D007958:Leukocyte Count / Q000528:radiation effects*; D051379:Mice; D008813:Mice, Inbred ICR; D009929:Organ Size / Q000528:radiation effects; D012016:Reference Values; D012156:Reticulocytes / Q000528:radiation effects; D013154:Spleen / Q000033:anatomy & histology / Q000473:pathology / Q000528:radiation effects*; D013997:Time Factors; D014916:Whole-Body Irradiation
D003037:Cobalt Radioisotopes; D006454:Hemoglobins