Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23-q31.
It has been shown that a nuclear factor, interferon regulatory factor-1 (IRF1), plays a key role in the regulation of the type I interferon (IFN) system by affecting the transcription of type I IFN and some IFN-inducible genes. In this study, the human IRF1 gene was mapped to chromosome 5 by analysis of mouse-human somatic cell hybrids. Furthermore, by linkage analysis based on RFLP (restriction fragment length polymorphism), the gene was localized to chromosome 5q23-q31, the region that has been termed "critical" for some myeloid disorders.
Itoh
S
S
Institute for Molecular and Cellular Biology, Osaka University, Japan.
Harada
H
H
Nakamura
Y
Y
White
R
R
Taniguchi
T
T
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D050856:Interferon Regulatory Factor-1; D051379:Mice; D010750:Phosphoproteins / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D005819:Genetic Markers; C494257:IRF1 protein, human; D050856:Interferon Regulatory Factor-1; C494258:Irf1 protein, mouse; D010750:Phosphoproteins; D014157:Transcription Factors; D004247:DNA