Nonorgan-specific autoantibodies in individuals infected with type 1 human immunodeficiency virus.
Fifty-six human immunodeficiency virus-1-positive asymptomatic carriers were tested for the presence of a variety of nonorgan-specific autoantibodies. Antinuclear antibodies were detected in 34 sera, of which 27 were directed to the mitotic spindle apparatus and all were of the IgG isotype. Anti-Golgi complex, anti-centriole, and anti-vimentin antibodies were also present in 20.4, and 4 sera, respectively. Ten patients had less than 500 CD4-carrying T lymphocytes per cubic millimeter. Nine of them had more than one autoantibody. No correlation could be demonstrated between the number of autoantibodies and the level of serum immunoglobulins.
Gentric
A
A
Department of Internal Medicine, Brest University Medical School, France.
Blaschek
M
M
Julien
C
C
Jouquan
J
J
Pennec
Y
Y
Berthelot
J M
JM
Mottier
D
D
Casburn-Budd
R
R
Youinou
P
P
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002353:Carrier State / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity / Q000276:immunology; D015497:HIV-1; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007136:Immunoglobulins