[Neuropeptides and inflammation: presumed mechanisms in neurogenic inflammation].
Neuropeptides, among which substance P, VIP (Vasoactive intestinal peptide), somatostatin, neurotensin, dynorphin and enkephalins, are able to modulate inflammatory processes. Increasing interest is now devoted to these peptides in different inflammatory diseases, concerning skin, lung and joins. The effect of substance P can be dependent on its C-terminal moiety implicating by this way an interaction with specific neurokinin receptors or can be dependent on its N-terminal moiety which does not involve a specific membrane receptor. Such diversity of the action mechanisms of peptides should influence the evolution of the anti-inflammatory therapeutic.
Landry
Y
Y
Laboratoire de Neuroimmunopharmacologie, Université Louis-Pasteur, Strasbourg, France.
Bloch
J G
JG
Mousli
M
M
Bueb
J L
JL
Bronner
C
C
D001168:Arthritis / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008407:Mast Cells / Q000502:physiology; D008565:Membrane Proteins / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D013373:Substance P / Q000502:physiology
D008565:Membrane Proteins; D009479:Neuropeptides; D013373:Substance P
Neuropeptides et inflammation: mécanismes présumés de l'inflammation neurogène.