Protein binding of cefpiramide in the plasma of various species.
The plasma protein binding of cefpiramide in man, dog, rabbit and rat was examined. Cefpiramide was more strongly bound to human plasma than to animal plasma and was exclusively bound to albumin. The characteristics of the protein binding of cefpiramide is one of the factors influencing the extrapolation of drug disposition from animals to man.
Department of Hospital Pharmacy, School of Medicine, Nagoya University, Japan.
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Ohshima
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T
Hasegawa
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I
Johno
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Kitazawa
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism* / Q000493:pharmacokinetics; D004285:Dogs; D006801:Humans; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D013045:Species Specificity
D001798:Blood Proteins; D002511:Cephalosporins; D012709:Serum Albumin; C036666:cefpiramide