Chromosomal location of the octamer transcription factors, Otf-1, Otf-2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genome.
Chromosomal locations have been assigned for the octamer transcription factor, Otf, gene family (previously named the octamer-binding protein, Oct, gene family) using an interspecific backcross of [(C57BL/6J x Mus spretus)F1 x C57BL/6J] mice and the BXH recombinant inbred strains. Molecular probes for Otf-1 and Otf-2 recognized single loci on mouse chromosomes 1 and 7, respectively, whereas probes for Otf-3 recognized a minimum of eight independently segregating loci (designated Otf-3a through Otf-3h). Members of the Otf-3 family mapped to mouse chromosomes 1, 2, 3, 6, 14, 17, and the X chromosome, indicating that the Otf family has become widely dispersed during evolution. Several Otf loci mapped near developmental mutations, raising the possibility that these mutations result from defects in Otf family members.
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research and Development Center, Maryland 21702.
L D
LD
Siracusa
M H
MH
Rosner
M A
MA
Vigano
D J
DJ
Gilbert
L M
LM
Staudt
N G
NG
Copeland
N A
NA
Jenkins
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D015342:DNA Probes / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D008040:Genetic Linkage; D015698:Genomic Library; D051863:Host Cell Factor C1; D051379:Mice; D008810:Mice, Inbred C57BL; D005810:Multigene Family; D050811:Octamer Transcription Factor-1; D050813:Octamer Transcription Factor-2; D050814:Octamer Transcription Factor-3; D012150:Polymorphism, Restriction Fragment Length; D014157:Transcription Factors / Q000235:genetics*
D015342:DNA Probes; D004268:DNA-Binding Proteins; C497693:Hcfc1 protein, mouse; D051863:Host Cell Factor C1; D050811:Octamer Transcription Factor-1; D050813:Octamer Transcription Factor-2; D050814:Octamer Transcription Factor-3; C494166:Pou2f1 protein, mouse; C489206:Pou2f2 protein, mouse; C494174:Pou5f1 protein, mouse; D014157:Transcription Factors