Comparative effects of antidepressants, amitriptyline, and maprotiline on intraventricular conduction, effective refractory period, and incidence of ventricular arrhythmias induced by programmed stimulation in dog hearts after myocardial infarction.
The effects of amitriptyline and maprotiline, standard tricyclic and tetracyclic antidepressants, on intraventricular conduction, the effective refractory period (ERP), and the incidence of ventricular arrhythmias induced by programmed stimulation were studied and compared in dog hearts after myocardial infarction. Amitriptyline at doses of 1-3 mg/kg significantly slowed ventricular conduction of the infarcted zones in a frequency-dependent and dose-dependent manner. Amitriptyline at doses of 2 and 3 mg/kg slowed conduction slightly in normal zones. The ERP was prolonged by amitriptyline at a dose of 2 mg/kg. Amitriptyline increased the incidence of ventricular arrhythmias induced by programmed stimulation. Maprotiline at doses of 1-3 mg/kg slowed conduction in infarcted zones to a lesser extent as compared with amitriptyline, although severely depressed conduction in the infarcted zone was obviously slowed by maprotiline. Maprotiline did not increase the incidence of ventricular arrhythmias significantly. From the present results, maprotiline appears to have less cardiac toxicity than amitriptyline, although maprotiline produces a slight decrease in conduction of infarcted zones.
Department of Pharmacology, Hamamatsu University School of Medicine, Japan.
H
H
Hashimoto
M
M
Nishimoto
T
T
Ozaki
K
K
Oohara
M
M
Nakashima
D000200:Action Potentials / Q000187:drug effects; D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D004562:Electrocardiography; D006329:Heart Conduction System / Q000187:drug effects* / Q000502:physiology; D008376:Maprotiline / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000503:physiopathology*; D012032:Refractory Period, Electrophysiological / Q000187:drug effects*
D000639:Amitriptyline; D008376:Maprotiline