Lack of Leu-3a epitope on T-helper (CD4) lymphocytes.
Human T-helper cells express membrane-bound CD4 antigen whose many epitopes are recognized by different monoclonal antibodies. The epitope recognized by Leu-3a and similar clones has been shown to be the location for human immunodeficiency virus (HIV) receptor. We have found a unique blood donor whose CD4+ T-helper lymphocytes were lacking Leu-3a epitope. CD4+ T-helper cells lacking Leu-3a epitope might be resistant to HIV infection.
Department of Pathology, Nassau County Medical Center, Stony Brook, East Meadow, New York.
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D000328:Adult; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D015704:CD4 Antigens / Q000276:immunology*; D000939:Epitopes; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D006377:T-Lymphocytes, Helper-Inducer / Q000032:analysis / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D015704:CD4 Antigens; D000939:Epitopes