[Comparison of central effects produced by intracerebral injection of glutamic acid, quisqualic acid, and kainic acid].
Icv glutamic acid (Glu), quisqualic acid (QA) and kainic acid (KA) significantly increased spontaneous activity of mice in photecell box, and induced dose-dependent rise of blood pressure in anesthetized rats. Their intensities were arranged in the order of KA greater than Glu greater than QA. In mice step-through test Glu 0.1 micrograms icv improved learning and memory; KA 1 ng had no evident effect; and QA 0.1 microgram impaired learning and memory, which were also confirmed by step-down test in normal mice. Therefore, the non-NMDA (N-methyl-D-aspartate) receptor subtype might be different from the NMDA receptor subtype in the action of learning and memory.
Sun
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Department of Pharmacology, Wenzhou Medical College, China.
Zhang
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D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D018698:Glutamic Acid; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D016318:Quisqualic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005971:Glutamates; D018698:Glutamic Acid; D016318:Quisqualic Acid; D007608:Kainic Acid