[Malignant neuroleptic syndrome associated with myocardial infarction, acute renal insufficiency and rhabdomyolysis].
We present a case of malignant neuroleptic syndrome in a 55 years old male diagnosed 3 years ago of alcoholic paranoid psychosis who was chronically treated with haloperidol, clothiapine, and phenobarbital. Twenty one days after neuroleptic drug withdrawal the patient was admitted to the recovery room because of hyperthermia (40.2 degrees C), left basal pneumonia, acute respiratory insufficiency, extrapyramidal rigidity, mutism, dysarthria, deep coma, hypotension, and tachycardia. Two days after he presented massive rhabdomyolysis, atrial flutter with hemodynamic deterioration which reverted to sinus rhythm and acute anterolateral and inferior myocardial infarction documented by enzyme rise and electrocardiographic alterations. Rhabdomyolysis and myocardial infarction were the precipitating factors of the renal insufficiency. A malignant neuroleptic syndrome was suspected and intravenous treatment with dantrolene sodium 1.5 mg/kg every 24 hours was initiated. Bromocriptine was not administered. The patient died 14 days after in the course of a sepsis and cardiogenic shock.
Benatar Haserfaty
J
J
Centro Especial Ramón y Cajal, Madrid.
García Pérez del Río
J
J
Román Tabernero
M
M
Durán Insúa
F
F
Ascorve Domínguez
A
A
D058186:Acute Kidney Injury / Q000209:etiology*; D003620:Dantrolene / Q000627:therapeutic use; D003987:Dibenzothiazepines / Q000009:adverse effects*; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D009459:Neuroleptic Malignant Syndrome / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D010634:Phenobarbital / Q000009:adverse effects; D011604:Psychoses, Alcoholic / Q000150:complications / Q000188:drug therapy; D012206:Rhabdomyolysis / Q000209:etiology*; D012307:Risk Factors
D003987:Dibenzothiazepines; D003620:Dantrolene; D006220:Haloperidol; D010634:Phenobarbital
Síndrome neuroléptico maligno asociado a infarto de miocardio, insuficiencia renal aguda y rabdomiólisis.