[The mechanism of the inhibitory effects of oren-gedoku-to (OGT) on gastric acid secretion in rats].
The effect of oren-gedoku-to (OGT) on gastric acid secretion was examined in the perfused stomach of anesthetized rats. OGT (10-100 mg/kg) given intraperitoneally dose-dependently inhibited the gastric acid secretion stimulated by intracerebroventricular DN-1417, an analogue of TRH, but failed to inhibit the acid secretion stimulated by intracerebroventricular baclofen, an analogue of GABA. The inhibitory effect of OGT on DN-1417-induced acid secretion was antagonized by haloperidol (0.3 and 1.0 mg/kg, i.p.), a dopamine-1/2 antagonist or sulpiride (100 mg/kg, i.p.), a dopamine-2 antagonist; and it was also reversed by yohimbine (0.3 mg/kg, i.p.), an alpha-2 adrenergic antagonist, and prazosin, an alpha-1 antagonist. These results suggest that the ability of OGT to reduce acid secretion is mediated via not only dopamine receptors but also alpha-2 adrenoceptors.
Takase
H
H
Kanebo, Ltd., Kampo Research Laboratories, Osaka, Japan.
Tatsumi
Y
Y
Miura
O
O
Yumioka
E
E
Suzuki
A
A
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001418:Baclofen / Q000037:antagonists & inhibitors; D003864:Depression, Chemical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D015016:Yohimbine / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D004365:Drugs, Chinese Herbal; D011942:Receptors, Adrenergic, alpha; D011954:Receptors, Dopamine; D015016:Yohimbine; D013973:Thyrotropin-Releasing Hormone; D001285:Atropine; D013469:Sulpiride; C029762:DN 1417; D001418:Baclofen; D006220:Haloperidol; D010646:Phentolamine