Apomorphine--test in dystonia.
In a doubleblind, placebocontrolled design subcutaneous apomorphine was given to 7 patients with dystonic movement disorders to assess dopamine sensitivity of their symptoms. Five patients who displayed a marked clinical improvement after the apomorphine test injections subsequently responded to oral or continuous dopaminergic therapy. The effective apomorphine doses correlated with the doses of dopaminergic drugs. Two non-responders to apomorphine did not benefit from dopaminergic therapy. Apomorphine application thus seems to be a valuable test predicting dopamine sensitivity in dystonia.
Langkafel
M
M
Department of Neurology, University of Bochum, St. Josef-Hospital, Federal Republic of Germany.
Heinz
A
A
Schöls
L
L
Przuntek
H
H
D001058:Apomorphine; D015259:Dopamine Agents / Q000627:therapeutic use*; D004311:Double-Blind Method; D004421:Dystonia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D011237:Predictive Value of Tests
D015259:Dopamine Agents; D001058:Apomorphine