Anti-neutrophil cytoplasmic autoantibodies in a child with pauci-immune necrotizing and crescentic glomerulonephritis.
We report a case of pauci-immune, necrotizing and crescentic glomerulonephritis in a 10-year-old child initially thought to have Henoch-Schönlein purpura. The diagnosis of a Wegener's granulomatosis-microscopic polyarteritis disorder was made on the basis of clinical presentation and a positive anti-neutrophil cytoplasmic autoantibody (ANCA). This case illustrates the usefulness of the ANCA in the diagnosis and management of childhood vasculitides.
Baldree
L A
LA
Department of Pediatrics, LeBonheur Children's Medical Center, University of Tennessee, Memphis.
Gaber
L W
LW
McKay
C P
CP
D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003524:Cyclosporins / Q000627:therapeutic use; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010488:Polyarteritis Nodosa / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use
D001323:Autoantibodies; D003524:Cyclosporins; D011241:Prednisone