The antiperinuclear factor. I. Clinical and serologic associations.
The antiperinuclear factor (APF) test raises two main problems: the unpredictability of the cells used as substrate and the difficulty in expressing the results. We propose that 10% of the cells have to be stained by a given serum in order for it to be considered positive. APF were found to be present in 76% of rheumatoid arthritis (RA) patients, 3% of healthy controls and occasionally in disease controls. The production of APF was significantly (p less than 0.01) related to the presence of rheumatoid factor in RA, and IgG antibody was predominant in the APF test.
Youinou
P
P
Department of Immunology, Brest University Medical School Hospital, France.
Le Goff
P
P
Dumay
A
A
Lelong
A
A
Fauquert
P
P
Jouquan
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis* / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D002610:Cheek; D005069:Evaluation Studies as Topic; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000032:analysis; D013194:Staining and Labeling
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007074:Immunoglobulin G; C030902:antiperinuclear factor