Effect of FK 506 on spontaneous diabetes in BB rats.
From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg.kg-1.day-1 (n = 19) or 2 mg.kg-1.day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, approximately 75% of the rats that were diabetes free at 120 days remained so.
Department of Surgery, University Health Center of Pittsburgh, University of Pittsburgh, Pennsylvania.
N
N
Murase
I
I
Lieberman
M A
MA
Nalesnik
D H
DH
Mintz
S
S
Todo
A L
AL
Drash
T E
TE
Starzl
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001327:Autoimmune Diseases / Q000473:pathology / Q000517:prevention & control; D001786:Blood Glucose / Q000032:analysis; D003524:Cyclosporins / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D006168:Guinea Pigs; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007328:Insulin / Q000032:analysis; D007376:Interleukin-2 / Q000235:genetics; D007377:Interleukin-3 / Q000235:genetics; D010179:Pancreas / Q000737:chemistry / Q000473:pathology; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics; D011863:Radioimmunoassay; D051381:Rats; D011913:Rats, Inbred BB; D011919:Rats, Inbred Strains; D016559:Tacrolimus; D014158:Transcription, Genetic / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001786:Blood Glucose; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D007328:Insulin; D007376:Interleukin-2; D007377:Interleukin-3; D012333:RNA, Messenger; D016559:Tacrolimus