Comparison of healing of lesions in the calvarium of foetal lambs and young sheep.
This study compares the healing of lesions made in the occipital region of the calvarium of 5 foetal and 4 post-natal lambs. The foetuses, operated on between the 83rd and 91st day of gestation, had a bone flap elevated and the post-natal lambs, aged about 6 weeks, had a craniectomy and replacement of the bone pieces. The foetuses were delivered spontaneously at full-term. All the animals had computed tomographic (CT) scans and, after sacrifice, naked eye examination of the bony lesions. These showed that there was poor ossification of the lesions made in the foetuses compared to those made in the post-natal lambs. These findings need to be taken into account when intra-uterine correction of cranio-facial deformities are being contemplated.
Department of Neurosurgery, North Manchester General Hospital, UK.
C M
CM
Bannister
J J
JJ
Cranley
I W
IW
Turnbull
J
J
Weller
G
G
Koutsoubelis
D000367:Age Factors; D010808:Physical Examination / Q000379:methods; D012886:Skull / Q000000981:diagnostic imaging / Q000196:embryology / Q000293:injuries*; D014057:Tomography, X-Ray Computed; D014945:Wound Healing / Q000502:physiology*