Assessment of beta-1 selectivity of bisoprolol and atenolol by means of their influence on the lipolytic response to an infusion of terbutaline.
We have investigated the beta-1 selectivity of a new beta-blocker, Bisoprolol, by comparing its effect on lipolysis induced by intravenous terbutaline infusion with that of Atenolol. At a dose of 5 mg, Bisoprolol had virtually no beta-2 blocking activity as measured by free fatty acid (FFA) release during terbutaline infusion. At a dose of 10 mg, Bisoprolol had a small but statistically insignificant effect on FFA release similar to 50 mg Atenolol. At a dose of 20 mg, Bisoprolol had significant beta-2 blocking activity. At lower doses, therefore, Bisoprolol is a very selective beta-blocker.
Department of Clinical Pharmacology, Medical School, Edgbaston, Birmingham, U.K.
M J
MJ
Kendall
S
S
Akhlaghi
C A
CA
Haffner
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001262:Atenolol / Q000008:administration & dosage / Q000494:pharmacology*; D017298:Bisoprolol; D004305:Dose-Response Relationship, Drug; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D011412:Propanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D016037:Single-Blind Method; D013726:Terbutaline / Q000494:pharmacology
D000319:Adrenergic beta-Antagonists; D005230:Fatty Acids, Nonesterified; D011412:Propanolamines; D001262:Atenolol; D013726:Terbutaline; D017298:Bisoprolol