Chronic multifocal osteomyelitis, a new recessive mutation on chromosome 18 of the mouse.
Mice with tail kinks and deformities in their lower extremities were observed in a litter of C.D2-Qa-2+N6F15 mice. A mutant line that exhibits this phenotype in 100% of its offspring was established by subsequent breeding. The abnormalities resembled to some degree those found in a human syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). Accordingly, we name the new mutation chronic multifocal osteomyelitis (cmo). Breeding analysis showed that the defect was determined by a single autosomal recessive gene. Restriction fragment length polymorphism (RFLP) analysis of progeny from a backcross between Mus musculus domesticus (CLA) and C.D2-Qa-(2+)-cmo/cmo indicated that the cmo gene resides on mouse Chromosome 18.
Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
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Byrd
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Grossmann
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Potter
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Shen-Ong
D000818:Animals; D002874:Chromosome Mapping; D002908:Chronic Disease; D003433:Crosses, Genetic; D005260:Female; D005808:Genes, Recessive; D008297:Male; D051379:Mice; D009154:Mutation; D010019:Osteomyelitis / Q000235:genetics*; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length