Effects of long-term treatment with naltrexone on hepatic enzyme activity.
The influence of naltrexone on liver function in heroin addicts was studied, with respect to the metabolizing function by using the antipyrine clearance and to cellular damage by monitoring plasma levels of hepatic enzymes. The clearance of antipyrine was not affected by naltrexone treatment, and, during the study period, the use and withdrawal of benzodiazepines and alcohol did not change this parameter; moreover, there was no relationship between changes in plasma hepatic enzymes and antipyrine half-life. Mean plasma levels of hepatic enzymes did not show significant modification in the course of treatment with naltrexone.
Clinical Pharmacology Department, University of Modena, Italy.
L A
LA
Pini
C
C
Ferretti
T
T
Trenti
A
A
Ferrari
E
E
Sternieri
D000284:Administration, Oral; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000983:Antipyrine / Q000097:blood / Q000493:pharmacokinetics*; D002188:Cannabis; D005260:Female; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009271:Naltrexone / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000188:drug therapy*; D005723:gamma-Glutamyltransferase / Q000097:blood
D009271:Naltrexone; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000983:Antipyrine