Limb vascular responsiveness to beta-adrenergic receptor stimulation in patients with congestive heart failure.
BACKGROUND
In patients with congestive heart failure, the chronotropic and inotropic responses to beta-adrenergic agonists are reduced. It is not known whether desensitization of peripheral beta-adrenoceptors accounts for impaired limb vasodilation in these patients. Accordingly, we studied 14 normal subjects and 13 age-matched patients with congestive heart failure.


RESULTS
To distinguish vasodilation mediated by beta-adrenoceptors and adenylate cyclase from that mediated by stimulation of guanylate cyclase, each subject received intrabrachial artery infusions of isoproterenol (1-100 ng/min) and sodium nitroprusside (0.3-10 micrograms/min), respectively. Forearm blood flow was determined by venous occlusion plethysmography. Maximal vasodilative potential, determined during reactive hyperemia, was reduced in the patients with congestive heart failure. The maximal forearm blood flow response to isoproterenol was comparable in patients with heart failure and in normal subjects (8.0 +/- 1.1 versus 9.2 +/- 1.2 ml/100 ml of tissue/min, respectively, p = NS). Furthermore, the dose-response relation to isoproterenol was similar in both groups. Likewise, the forearm vasodilative response to sodium nitroprusside was preserved in the heart failure group. Plasma concentration of norepinephrine was higher in the patients with heart failure (436 +/- 34 versus 201 +/- 74 pg/ml, p less than 0.01). When both groups were considered, there was no correlation between norepinephrine levels and the maximal forearm blood flow response to isoproterenol (r = 0.10, p = NS).


CONCLUSIONS
We conclude that beta-adrenoceptor desensitization does not occur in the limb vessels of patients with congestive heart failure.
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115.
M A
MA
Creager
R J
RJ
Quigg
C J
CJ
Ren
M A
MA
Roddy
W S
WS
Colucci
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000328:Adult; D002395:Catecholamines / Q000097:blood; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012044:Regression Analysis
D000318:Adrenergic beta-Agonists; D002395:Catecholamines; D009599:Nitroprusside; D007545:Isoproterenol