Nutritional copper deficiency does not affect sponge granuloma formation in the rat.
Sponge granuloma formation was compared in copper-deficient and copper-sufficient rats following feeding of respective diets for 20, 40, or 60 d. Body weight, total blood hemoglobin, and activities of ceruloplasmin and Cu, Zn-superoxide dismutase in plasma were monitored to ascertain copper deficiency. Mean granuloma weights (mg +/- SEM) in copper-deficient and copper-sufficient groups of rats, respectively, were as follows: 37 +/- 2 and 38 +/- 2 after 20 d, 22 +/- 2 and 23 +/- 2 after 40 d, and 19 +/- 1 and 21 +/- 1 after 60 d on respective diets. Thus, nutritional copper deficiency did not have an effect on sponge granuloma formation in the rat.
Kishore
V
V
College of Pharmacy, Xavier University of Louisiana, New Orleans 70125.
Boutte
V
V
Fourcade
L
L
D000818:Animals; D001835:Body Weight / Q000502:physiology; D002570:Ceruloplasmin / Q000502:physiology; D003300:Copper / Q000097:blood / Q000172:deficiency*; D006099:Granuloma / Q000139:chemically induced / Q000209:etiology* / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000097:blood
D006454:Hemoglobins; D003300:Copper; D013482:Superoxide Dismutase; D002570:Ceruloplasmin