Symptomatic bradycardia caused by mianserin at therapeutic doses.
An acute episode of symptomatic sinus bradycardia, occurred in a 50-year-old female patient after she had been given a single therapeutic dose of mianserin. Heart rate was corrected by atropine injection. Re-administration of mianserin resulted in the recurrence of bradycardia. Further examination showed no cardiac abnormalities. This case is the first report of conduction defect in a patient given therapeutic doses of mianserin.
Carcone
B
B
Service de Médecine, Hôtel Dieu, Le Creusot, France.
Vial
T
T
Chaillet
N
N
Descotes
J
J
D001919:Bradycardia / Q000139:chemically induced*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D008803:Mianserin / Q000009:adverse effects*; D008875:Middle Aged
D008803:Mianserin