Effects of cysteamine on flexion reflex facilitation by C-primary afferents in cats.
Brief (20 s) conditioning stimuli at C-fiber intensity applied to the sural or gastrocnemius nerve evoked a facilitation of the flexor alpha-motoneurone discharges from small filaments of the posterior biceps semitendinosus nerve produced by subcutaneous stimulation of the plantar region in anesthetized spinal cats. Such C afferent-induced facilitation was blocked reversibly by cysteamine (50 mg.kg-1), a somatostatin depletor, without affecting the basic mechanisms of flexor reflexes, suggesting an important role played by somatostatin in transmission and/or modulation of nociceptive information in the spinal cord.
Shanghai Brain Research Institute, Chinese Academy of Sciences.
C Q
CQ
Li
Z Q
ZQ
Zhao
H Q
HQ
Yang
D000818:Animals; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects*; D003543:Cysteamine / Q000494:pharmacology*; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects*; D013004:Somatostatin / Q000037:antagonists & inhibitors; D013497:Sural Nerve / Q000502:physiology
D013004:Somatostatin; D003543:Cysteamine