[Preparation of rotundine-chitosan gelled granules and their drug-release tests].
The paper described a delivery system prepared from granulation of a chitosan solution containing rotundine in a coagulating bath and examined the effects of the ratios of rotundine: chitosan, crosslinking agents and molecular weight of chitosan on the analgesic release rate. It was shown that the rotundine (56.7%)-chitosan (Mw:5.70 x 10(5) degree of deacetylation: 72.4%) gelled granules in an artificial gastroenteric juice (pH 1.0 and 7.2) have T50 of 40 and 180 min respectively, and the total release time sustained over 540 min.
Chengdu Institute of Organic Chemistry, Academia Sinica.
X J
XJ
Liu
S S
SS
Xie
Y X
YX
Zhang
J L
JL
Zhang
D
D
Zhang
Y L
YL
Wang
D
D
Ni
D
D
Li
M
M
Lu
Q T
QT
Ye
D000470:Alkaloids / Q000008:administration & dosage*; D000700:Analgesics / Q000008:administration & dosage*; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001600:Berberine Alkaloids / Q000008:administration & dosage*; D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D048271:Chitosan; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems
D000470:Alkaloids; D000700:Analgesics; D014150:Antipsychotic Agents; D001600:Berberine Alkaloids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002686:Chitin; C014215:tetrahydropalmatine; D048271:Chitosan