Increased expression of the CD45RO (memory) antigen on T cells in HIV-infected children.
Expression of the CD45RO putative memory cell antigen on CD4 (helper) and CD8 (cytotoxic/suppressor) lymphocytes of children born to HIV-infected women was investigated using the UCHL1 antibody. Significantly raised numbers of CD45RO+ CD8 lymphocytes were found in all nine of the infected children compared with uninfected and control children. Expression of CD45RO on CD4 lymphocytes was variable; absolute numbers were not increased, although the percentage was increased in four out of nine infected children. All the infected children except two (who had comparatively low numbers of CD45RO+ CD8 cells) were clinically well, which suggests that an increase in CD45RO+ CD8 cells may be indicative of a functionally active immune response against HIV.
Froebel
K S
KS
HIV Immunology Unit, University Department of Medicine, Edinburgh, Scotland, UK.
Doherty
K V
KV
Whitelaw
J A
JA
Hague
R A
RA
Mok
J Y
JY
Bird
A G
AG
D015703:Antigens, CD / Q000096:biosynthesis*; D000943:Antigens, Differentiation / Q000096:biosynthesis*; D000945:Antigens, Differentiation, T-Lymphocyte; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016827:CD8 Antigens; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000096:biosynthesis*; D006801:Humans; D007223:Infant; D017493:Leukocyte Common Antigens; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D016827:CD8 Antigens; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens