Mycobacterium bovis infection in human beings in contact with elk (Cervus elaphus) in Alberta, Canada.
Human infection with Mycobacterium bovis is rare in developed countries because of milk pasteurisation and the slaughter of infected cattle. An epizootic of M bovis infection in domesticated elk (Cervus elaphus) in Alberta, Canada, which started in April, 1990, prompted us to seek human contacts of elk herds. There were 446 identified contacts, in 394 of whom tuberculin skin tests were done. Of 81 contacts who were skin-test positive, 50 had been in contact with culture-positive animals. 6 of 106 subjects tested a second time became tuberculin positive. 1 case of active M bovis infection was diagnosed by sputum culture. The mode of transmission of M bovis from these farm animals to man is likely to be aerosolisation of infected particles. Because of the apparent susceptibility of farmed Cervidae (deer) to M bovis infection, and the evidence of spread to man, control measures to prevent human infection should be developed.
Department of Medicine, Walter MacKenzie Health Sciences Centre, University of Alberta, Edmonton, Canada.
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Fanning
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Edwards
D000328:Adult; D000368:Aged; D000416:Alberta / Q000453:epidemiology; D000822:Animal Husbandry; D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D016358:Contact Tracing / Q000379:methods*; D003670:Deer / Q000382:microbiology*; D004196:Disease Outbreaks / Q000517:prevention & control; D006801:Humans; D009163:Mycobacterium bovis / Q000276:immunology / Q000302:isolation & purification*; D009784:Occupational Diseases / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology; D012307:Risk Factors; D013183:Sputum / Q000382:microbiology; D013633:Tanning; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D014730:Veterinary Medicine
D000995:Antitubercular Agents