On the putative mechanism of induction and regulation of melanogenesis by L-tyrosine.
The stimulation of melanogenesis by L-tyrosine in hamster melanoma is several-fold higher than that by norepinephrine, epinephrine, clonidine and isoproterenol and absent in the case of tyramine dopamine and phenylephrine. Therefore, the melanogenic effect of L-tyrosine in hamster melanoma follows a different pathway than that linked to the activation of dopaminergic and adrenergic receptors.
Department of Microbiology and Immunology, Albany Medical College, NY 12208.
J
J
Howe
R
R
Costantino
A
A
Slominski
D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D002460:Cell Line; D003000:Clonidine / Q000494:pharmacology; D006224:Cricetinae; D007545:Isoproterenol / Q000494:pharmacology; D008543:Melanins / Q000096:biosynthesis*; D008546:Melanoma, Experimental / Q000201:enzymology / Q000378:metabolism; D014442:Monophenol Monooxygenase / Q000378:metabolism; D010656:Phenylephrine / Q000494:pharmacology; D014439:Tyramine / Q000494:pharmacology; D014443:Tyrosine / Q000494:pharmacology* / Q000502:physiology
D002395:Catecholamines; D008543:Melanins; D010656:Phenylephrine; D014443:Tyrosine; D014442:Monophenol Monooxygenase; D007545:Isoproterenol; D003000:Clonidine; D014439:Tyramine