Ocular hypotensive activity of pirbuterol eye drops in rabbits.
The IOP-lowering effect of pirbuterol, a beta-2 adrenergic agonist, was studied in rabbits. In normotensive rabbits, pirbuterol 0.5% eye drops reduced IOP by 20-25%. In ocular hypertensive rabbits (by glucose 5% venous infusion), pirbuterol reduced IOP by 20% (0.1% concentration) to 40% (0.5% and 1% concentration). A slight decrease in the effect was noticed after seven days of treatment.
Department of Ophthalmology, University of Verona, Italy.
L
L
Bonomi
S
S
Perfetti
R
R
Bellucci
I
I
De Franco
D000287:Administration, Topical; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions / Q000494:pharmacology; D011817:Rabbits; D014065:Tonometry, Ocular
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; D009883:Ophthalmic Solutions; C009118:pirbuterol