Skin conductance orienting response in unmedicated RDC schizophrenic, schizoaffective, depressed, and control subjects.
In an evaluation of the skin conductance orienting response (SCOR) as a marker for schizophrenia, skin conductance (SC) activity was studied in 36 Research Diagnostic Criteria (RDC) schizophrenic (SCZ), 17 schizoaffective--mainly schizophrenic (SA), 24 depressed (DEP), and 25 psychiatrically well control (CONT) subjects. All subjects were unmedicated. Data are presented from four paradigms: a series of 1 s 70 dB tones in a no-task habituation paradigm; a similar series of 103 dB tones; a series of tones with a button-press (reaction time) task; and a loud white noise stimulus (without task). The proportion of SCOR nonresponse to the first 70 dB tone was 39% for SCZ, 82% for SA, 46% for DEP, and 36% for CONT subjects; the response rate for SA subjects was significantly lower than for all other groups. The CONT group was less responsive than in most previous studies. SCZ subjects did not show increased responsivity to more intense and to task-relevant stimuli, although SA subjects did show such increases. DEP subjects showed some evidence of autonomic hyperarousal (higher tonic SC level, trend toward more spontaneous SC responses). The overall pattern of results does not support SCOR to neutral, moderate-intensity tones as a specific marker for schizophrenia, although there was some evidence for a generalized decrease in autonomic responsivity to stimuli.
Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia, 19129.
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Levinson
D000161:Acoustic Stimulation; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001143:Arousal / Q000235:genetics / Q000502:physiology; D001288:Attention / Q000187:drug effects / Q000502:physiology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D005712:Galvanic Skin Response / Q000235:genetics / Q000502:physiology; D005819:Genetic Markers / Q000235:genetics; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D006801:Humans; D009949:Orientation / Q000187:drug effects / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology / Q000523:psychology; D011930:Reaction Time / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D012559:Schizophrenia / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D005819:Genetic Markers