[Plasma level of lidocaine and adrenaline in local anesthesia with addition of colloid in eye surgery].
This study was undertaken to investigate the plasma levels of lidocaine and adrenaline after local anaesthesia for ophthalmic surgery and the influence of addition of hydroxyethyl starch (HES) on the resorption of the local anaesthetic solution. Prior to cataract surgery, two groups (each consisting of 10 patients) received a retrobulbar block (5 ml) and a facial nerve block (5 ml; O'Brien technique) with lidocaine 2% and adrenaline 1:80000, with or without addition of 10% HES 200/0.5 (relation 1:1) in equal volumes and concentrations. The plasma levels of lidocaine and adrenaline were measured by high-pressure liquid chromatography. In both groups, the individual peak concentrations of lidocaine (8.62 micrograms/ml) and adrenaline (7.514 pg/ml) reached the toxic range. There was no evidence of intravascular injection, and no severe cardiovascular reactions were observed. In 9 patients, resorption was slow and led to low peak concentrations. A rapid resorption with high peak concentrations was found in 11 patients. Peak levels of lidocaine were reached after 15 min and those of adrenaline after 3-5 min. Plasma levels of lidocaine and adrenaline were not significantly influenced by the addition of HES, although the highest peak concentrations were found in the group without the addition of HES.
Adams
H A
HA
Abteilung für Anästhesiologie, Justus-Liebig-Universität, Giessen.
Hessemer
V
V
Jacobi
K W
KW
Hempelmann
G
G
D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local; D002387:Cataract Extraction; D004837:Epinephrine / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007910:Lenses, Intraocular; D008012:Lidocaine / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013213:Starch / Q000031:analogs & derivatives*
D006895:Hydroxyethyl Starch Derivatives; D013213:Starch; D008012:Lidocaine; D004837:Epinephrine
Plasmaspiegel von Lidocain und Adrenalin bei Lokalanästhesie mit Kolloidzusatz am Auge.