International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC publication No. 19. The classification of carcinogens identified in the rodent bioassay as potential risks to humans: what type of substance should be tested next?
The relevance of rodent cancer bioassay data to humans is discussed in relation to the needs of regulatory agencies. The usefulness of in vivo and in vitro genotoxicity testing in this connection is also discussed. In the case of rodent carcinogens that do not elicit genotoxicity, it is suggested that homeostatic imbalance, cell proliferation, and other processes may play a major role in tumor development and its importance to the possible ability of the test agent to induce human cancer. These possibilities need to be evaluated on a case by case basis. The methods by which chemicals are selected for the rodent cancer bioassay are also discussed and it is pointed out that naturally-occurring constituents of human foods should in future receive greater priority as a consequence of anticipated changes resulting from biotechnology.
Toxicology Research Division, Health Protection Branch, Health and Welfare Canada, Ottawa.
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D000818:Animals; D015197:Carcinogenicity Tests; D002274:Carcinogens, Environmental / Q000032:analysis* / Q000145:classification; D004785:Environmental Pollutants / Q000032:analysis*; D005502:Food; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis / Q000145:classification; D012306:Risk; D012377:Rodentia
D002274:Carcinogens, Environmental; D004785:Environmental Pollutants; D009153:Mutagens