Prolonged radioprotective activity of WR-2721 linked to dextran.
The radioprotective agent WR-2721 was linked to dextran and poly(glutamic acid) respectively, to obtain a prolonged radioprotective ability. Male mice were administered these water soluble polymer conjugates one to 72 hours prior to a whole body irradiation with X-rays. A prolongation of radioprotective efficiency was achieved with two dextran-(WR-2721)-conjugates. For a period of 24 hours between administration, and irradiation dose reduction factors of 1.14 +/- 0.04 and 1.10 +/- 0.03 respectively were found. After 72 hours, no protective effect was observed. Histopathological investigations of the liver for formation of tumors 200 to 600 days after irradiation seems to indicate that a protective effect is not produced by the dextran-(WR-2721)-conjugates.
Institut für Biophysik und Strahlenbiologie der Universität Freiburg.
H
H
Mönig
H
H
Sedlmeier
W
W
Oehlert
G
G
Konermann
O
O
Messerschmidt
D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D003911:Dextrans / Q000494:pharmacology*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D008297:Male; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000473:pathology / Q000517:prevention & control; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D011829:Radiation Dosage; D013997:Time Factors
D003911:Dextrans; D009946:Organothiophosphorus Compounds; D004999:Amifostine