Grafting of catecholaminergic cells in the mammalian brain and reconstruction of disturbed function: basic problems to be solved.
1. Catecholaminergic cells were grafted in the caudate nucleus of hemi-Parkinsonian model rats, and the following problems were discussed. 2. Phenotypic plasticity and development of catecholamine-producing cells. 3. Mechanism of motor recovery. 4. Trophic factor. 5. Regulation of immunological responses. 6. Long-term survival and security.
Department of Physiology, Nagoya City University Medical School, Japan.
H
H
Nishino
T
T
Hashitani
M
M
Kumazaki
D000818:Animals; D001921:Brain / Q000196:embryology / Q000276:immunology; D016380:Brain Tissue Transplantation; D002395:Catecholamines / Q000096:biosynthesis*; D004195:Disease Models, Animal; D016332:Fetal Tissue Transplantation; D006085:Graft Survival; D010300:Parkinson Disease / Q000601:surgery*; D051381:Rats
D002395:Catecholamines