MIF-1 potentiates the action of tricyclic antidepressants in an animal model of depression.
In the present paper, the effect of simultaneous treatment of rats with low doses of MIF-1 and tricyclic antidepressants on rat behavior in the forced swim test was studied. It was found that MIF-1 stimulated in a dose-dependent manner "active" behavior of animals in this paradigm. The effect of MIF-1 appeared to be independent of changes in rats' locomotion in the open field test. The combined treatment of rats with MIF-1 (0.01 mg/kg IP) and amitriptyline (5 mg/kg IP) or desipramine (1.25 mg/kg) IP) significantly stimulated active behavior in the forced swim test above the level obtained with each of the drugs given separately. The present data suggest the potential clinical efficacy of a combined therapy of depressive patients with MIF-1 and small doses of tricyclic antidepressants.
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
W
W
Kostowski
W
W
Danysz
W
W
Dyr
E
E
Jankowska
P
P
Krzaścik
W
W
Pałejko
R
R
Stefański
A
A
Płaźnik
D000639:Amitriptyline / Q000494:pharmacology*; D000818:Animals; D003863:Depression; D003891:Desipramine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004357:Drug Synergism; D009075:MSH Release-Inhibiting Hormone / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological
D000639:Amitriptyline; D009075:MSH Release-Inhibiting Hormone; D003891:Desipramine