[The role of the opiate mechanisms of the hippocampus and substantia nigra in the behavioral and convulsive disorders in picrotoxin-induced kindling].
It was shown in the experiments on rats that the repeated picrotoxin administration resulted in the kindling of generalized seizures. Generalized convulsions were followed by the development of either postictal depression or explosiveness. The injection of mu-opiate agonist met-enkephalin into hippocampus of kindled rats resulted in the increase in the severity of seizure reactions which were induced by picrotoxin and also in the increase in the number of animals with postictal explosiveness. The injection of dynorphin-A-1-13 (kappa-opiate agonist) into substantia nigra reticulata induced the locomotor depression which was like one in postictal period and resulted in the decrease of picrotoxin-induced seizures severity. It was concluded that mu-opiate system of hippocampus took part in the formation of generator of pathologically enhanced excitation in the structure during kindling and the development of seizure syndrome, providing also the postictal explosiveness. Kappa-opiate system of substantia nigra plays an important role in the activation of the antiepileptic system, limitation of seizures and the development of postictal depression.
Kryzhanovskiĭ
G N
GN
Shandra
A A
AA
Godlevskiĭ
L S
LS
Mazarati
A M
AM
Nguyen
T T
TT
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004347:Drug Interactions; D004399:Dynorphins / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009294:Narcotics / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D011957:Receptors, Opioid / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology
D000700:Analgesics; D004399:Dynorphins; D004744:Enkephalin, Methionine; D009294:Narcotics; D010446:Peptide Fragments; D010852:Picrotoxin; D011957:Receptors, Opioid; C026843:dynorphin (1-13)
Rol' opiatnykh mekhanizmov gippokampa i chernoĭ substantsii v povedencheskikh i sudorozhnykh narusheniiakh pri pikrotoksinovom kindlinge.