The histamine H1-receptor antagonist binding site. Part I: Active conformation of cyproheptadine.
The active conformation of several histamine H1-antagonists is investigated. As a template molecule we used the antagonist cyproheptadine, which consists of a piperidylene ring connected to a tricyclic system. The piperidylene moiety is shown to be flexible. The global minimum is a chair conformation but, additionally, a second chair and various boat conformations have to be considered, as their energies are less than 5 kcal/mol above the energy of the global minimum. Two semi-rigid histamine H1-antagonists, phenindamine and triprolidine, were fitted onto the various conformations of cyproheptadine in order to derive the pharmacologically active conformation of cyproheptadine. At the same time, the active conformation of both phenindamine and triprolidine was derived. It is demonstrated that, within the receptor-bound conformation of cyproheptadine, the piperidylene ring most probably exists in a boat form.
Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.
M J
MJ
van Drooge
G M
GM
Donné-op den Kelder
H
H
Timmerman
D001665:Binding Sites; D003533:Cyproheptadine / Q000737:chemistry* / Q000378:metabolism; D006634:Histamine H1 Antagonists / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism; D012984:Software; D013816:Thermodynamics; D014311:Triprolidine / Q000737:chemistry / Q000378:metabolism
D006634:Histamine H1 Antagonists; D011725:Pyridines; D014311:Triprolidine; D003533:Cyproheptadine; C005430:phenindamine