Exclusion of linkage between familial Mediterranean fever and the human serum amyloid A (SAA) gene cluster.
We studied the relationship between the autosomal recessive trait familial Mediterranean fever (FMF) and the serum amyloid A (SAA) genes by comparing alleles of a highly polymorphic dinucleotide repeat and a conventional restriction fragment length polymorphism (RFLP) in the SAA gene cluster in Israeli FMF kindreds. By haplotype analysis, our data indicate a minimum crossover frequency of 22% between the SAA gene marker and FMF. By conventional linkage analysis this eliminates a minimum of 10.4 cM including and surrounding the SAA gene cluster as the site of the FMF mutation although SAA proteins are prominent physiologic markers of the acute attacks.
Sack
G H
GH
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Talbot
C C
CC
McCarthy
B G
BG
Harris
E L
EL
Kastner
D
D
Gruberg
L
L
Pras
M
M
D003434:Crossing Over, Genetic; D010505:Familial Mediterranean Fever / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male; D005810:Multigene Family; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D000685:Serum Amyloid A Protein / Q000235:genetics*
D000685:Serum Amyloid A Protein