Pulmonary infiltrates and eosinophilia associated with sulphasalazine administration.
A case of blood eosinophilia with pulmonary infiltrates associated with sulphasalazine therapy in a patient with ulcerative colitis is described. These manifestations resolved when sulphasalazine was ceased and recurred with rechallenge. The failure of recurrence after treatment with mesalazine (5-aminosalicyclic acid in a sustained release preparation) suggests that sulphapyridine is the component responsible for this reaction.
Barnet General Hospital, England.
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Panayiotou
D000328:Adult; D003093:Colitis, Ulcerative / Q000188:drug therapy; D006801:Humans; D008297:Male; D011657:Pulmonary Eosinophilia / Q000139:chemically induced*; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use
D012460:Sulfasalazine