Novel features of retroviruses associated with human diseases.
The last decade has witnessed a new chapter in the history of retrovirology. As of now, four human retroviruses have been identified and molecularly characterized. They are associated with a wide spectrum of human diseases including cancer, immunodeficiency and neurological disorders. By virtue of their clinical relevance, their novel genes and regulatory mechanisms these viruses have become the focal point of research in retrovirology. The study of these viruses is of fundamental importance in understanding the mechanisms leading to transformation of human cells and distortion of the immunological state.
Chandra
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Laboratory of Molecular Biology, (ZBC), University Medical School, Frankfurt, FRG.
Gerber
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T
Chandra
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D005814:Genes, Viral; D015658:HIV Infections / Q000382:microbiology; D015497:HIV-1 / Q000235:genetics* / Q000378:metabolism; D015498:HIV-2 / Q000235:genetics* / Q000378:metabolism; D015490:HTLV-I Infections / Q000382:microbiology; D015491:HTLV-II Infections / Q000382:microbiology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000378:metabolism; D015367:Human T-lymphotropic virus 2 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D015533:Transcriptional Activation
D012194:RNA-Directed DNA Polymerase