Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.
Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines.
Aichele
P
P
Institute of Pathology, University Hospital, Zürich, Switzerland.
Hengartner
H
H
Zinkernagel
R M
RM
Schulz
M
M
D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000032:analysis; D006183:H-2 Antigens / Q000276:immunology; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000517:prevention & control; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000276:immunology; D010455:Peptides / Q000138:chemical synthesis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014612:Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
D000939:Epitopes; D006183:H-2 Antigens; D009698:Nucleoproteins; D010455:Peptides; D014612:Vaccines; D014614:Vaccines, Synthetic; D014765:Viral Vaccines