[The part of lysosomal enzymes in drug-induced ulcerogenesis].
In the experiments on Wistar rats we showed that administration of ulcerogenic drugs (cinchophen, acetylsalicylic acid, butadione, indomethacin etc.) produced the alterations of free activity of lysosomal enzymes in the homogenates of ulcerated stomachs, presumably the significant elevation of the activity of cathepsins (more often cathepsin with optimum of activity at pH 5.5) and the significant reduction of free activity of acid nucleases (more often of DNA-ase). The alterations of free activity of lysosomal enzymes were as in cases with gastric ulcerations as in cases with unaffected stomachs.
Ostapchuk
N V
NV
D000818:Animals; D001241:Aspirin / Q000009:adverse effects; D002403:Cathepsins / Q000032:analysis*; D003851:Deoxyribonucleases / Q000032:analysis*; D007213:Indomethacin / Q000009:adverse effects; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D010653:Phenylbutazone / Q000009:adverse effects; D011804:Quinolines / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D012260:Ribonucleases / Q000032:analysis*; D013270:Stomach / Q000187:drug effects / Q000201:enzymology*; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000201:enzymology
D011804:Quinolines; D003851:Deoxyribonucleases; D012260:Ribonucleases; D002403:Cathepsins; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin
Uchastie lizosomal'nykh fermentov v lekarstvennom ul'tserogeneze.