[Biosynthesis and significance of acute phase proteins].
Acute phase proteins (APP) increase by the chemical receptors of macrophage via stimulations of either Fc or complement or other chemical receptors. No differences of APP pattern were observed by the different stimulants, because the effects of stimulation are changed by many processing steps in the macrophage as well as in the liver cell thereafter. Whether the APP increase results in good prognosis for original sickness or not are examined by multiple regression analysis in 38 cases of maxillary and 51 cases of laryngeal cancer with the observation for over five years. Alpha 1X contributes positively with length of their life, whereas alpha 1AG and ceruloplasmin contribute negatively. We could say that not all components of APP increase are advantageous for the diseases.
Cancer Research Institute, Kanazawa University.
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S
Migita
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M
Nonaka
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K
Onizuka
D000209:Acute-Phase Proteins / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000097:blood; D008441:Maxillary Neoplasms / Q000097:blood; D011379:Prognosis; D012044:Regression Analysis
D000209:Acute-Phase Proteins