A breakdown in macromolecular synthesis preceding differentiation in Streptomyces coelicolor A3(2).
A transitory cessation of growth was recorded in Streptomyces coelicolor A3(2) at the end of vegetative mycelium formation on solid medium. In the same phase a striking reduction in protein and nucleic acid synthesis was detected. Growth and macromolecular synthesis resumed, nearly reaching the original values, when morphological differentiation occurred. It is concluded that a physiological stress occurs within the bacterial population just before the onset of the morphological differentiation.
Dipartimento di Biologia Cellulare e dello Sviluppo, Sezione di Genetica, Università di Palermo, Italy.
C
C
Granozzi
R
R
Billetta
R
R
Passantino
M
M
Sollazzo
A M
AM
Puglia
D002453:Cell Cycle; D004261:DNA Replication; D004269:DNA, Bacterial / Q000378:metabolism; D007700:Kinetics; D014176:Protein Biosynthesis; D012329:RNA, Bacterial / Q000096:biosynthesis*; D013302:Streptomyces / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
D004269:DNA, Bacterial; D012329:RNA, Bacterial