Ion conductances affected by 5-HT receptor subtypes in mammalian neurons.
5-Hydroxytryptamine (5-HT) has both excitatory and inhibitory actions in the CNS and PNS. The development of new 5-HT ligands has led to the expansion of 5-HT receptor subtypes into three categories: 5-HT1, 5-HT2 and 5-HT3. Each category has further subdivisions. The literature concerning the biochemical basis of this division has been reviewed recently. While this approach has elucidated many of the pharmacological properties of 5-HT receptors, it has not addressed the question of how 5-HT modulates cell excitability. Physiological studies have confirmed the existence of a multiplicity of 5-HT receptors that act through a variety of ionic mechanisms. The purpose of this review is to summarize what is known of the ionic mechanisms associated with the activation of identified mammalian 5-HT receptor subtypes, as well as some effects of 5-HT where the receptor could not be defined.
Bobker
D H
DH
Vollum Institute, Oregon Health Science University, Portland 97201.
Williams
J T
JT
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
D011985:Receptors, Serotonin