[Pharmacology and mechanism of action of opioids administered by the peridural route].
The pharmacokinetics and pharmacodynamics of spinal narcotics are very important to determine dosage and intervals with bolus administration. Among known factors that may effect narcotic activity, lipid solubility seems to be the most important factor determining onset, greater dermatomal spread and longer duration of action than more lipid-soluble narcotics. This dermatomal spread is associated to a delayed respiratory depression which necessitates precautions and surveillance.
Département d'Anesthésie-Réanimation, Hôpital Ambroise Paré, Boulogne.
M
M
Chauvin
D015360:Analgesia, Epidural; D000701:Analgesics, Opioid / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans
D000701:Analgesics, Opioid
Pharmacologie et mode d'action des morphinomimétiques administrés par voie péridurale.