[Nonsedative H1 antihistaminics].
Recent research provided evidence that effective H1-antihistaminic drugs need not exert a central and sedative action. Non-sedative H1-antihistaminics can aptly replace older combined preparations of classical H1-antihistaminics, motivated by an effort to weaken their sedative action by the concurrent administration of pharmaceutical preparations with a central stimulating action (e.g. Bromadryl F). The new group of non-sedative histamine H1-antagonists uses in a rational way changes of the physical and chemical properties of these substances or differences in their affinity to histamine H1-receptors in different areas to reduce the incidence of typical undesirable effects.
Výzkumny ústav profarmacii a biochemii, Praha.
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H
Blehová
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Metys
D000818:Animals; D016589:Astemizole; D001559:Benzhydryl Compounds / Q000493:pharmacokinetics; D001562:Benzimidazoles / Q000493:pharmacokinetics; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics; D006801:Humans; D016593:Terfenadine
D001559:Benzhydryl Compounds; D001562:Benzimidazoles; D006634:Histamine H1 Antagonists; D016593:Terfenadine; D016589:Astemizole
Nesedativiní H1-antihistaminika.