Immunohistochemical localization of desmosomal and cytoskeletal proteins in the epidermis of healthy individuals and patients with Hailey-Hailey's disease.
We have studied the immunohistochemical localization of desmosomal and cytoskeletal proteins in the epidermis of healthy individuals and patients with Hailey-Hailey's disease. It was found that the localization of desmosomal proteins (desmoplakin, desmoglein) and keratin filaments in the involved epidermis of patients with Hailey-Hailey's disease was almost same as that in the normal epidermis of healthy individuals. In contrast, the localization of actin filaments in the involved epidermis of patients with Hailey-Hailey's disease differed from that in the normal epidermis of healthy individuals.
Inohara
S
S
Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan.
Tatsumi
Y
Y
Tanaka
Y
Y
Sagami
S
S
D000328:Adult; D003598:Cytoskeletal Proteins / Q000032:analysis*; D003896:Desmosomes / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008840:Microfilament Proteins / Q000032:analysis; D008875:Middle Aged; D010392:Pemphigus / Q000235:genetics* / Q000378:metabolism; D012867:Skin / Q000378:metabolism*
D003598:Cytoskeletal Proteins; D008840:Microfilament Proteins; D007633:Keratins