[Somatostatin in the treatment of established and severe acute pancreatitis in the rat].
The effects of somatostatin (SS) on the treatment of acute pancreatitis were studied in rats. Acute pancreatitis was established by injecting 5% sodium taurocholate in the biliopancreatic duct. Previously, pancreatic necrosis was determined in this experimental model at several intervals without treatment. Treatment was started according different groups: at 12, 16 and 20 hours after induction of acute pancreatitis (IV bolus of 4 ug/kg body weight followed by a 24h continuous infusion of 4 ug/kg body wt/hour). When somatostatin was initiated at 12 or 16h a decrease in serum amylase and lactodehydrogenase was observed, as well as in pancreatic necrosis resulting in 0% mortality after 24h of treatment. When somatostatin was started at 20h there was no changes in the lethal outcome of the disease.
Rueda Chimeno
J C
JC
Cirugía General, Hospital Montecelo, Pontevedra.
Argüello de Andrés
J M
JM
Ortega Medina
L
L
Landa García
J I
JI
Balibrea Cantero
J L
JL
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000627:therapeutic use*; D013656:Taurocholic Acid; D013997:Time Factors
D013004:Somatostatin; D013656:Taurocholic Acid
Somatostatina en el tratamiento de la pancreatitis aguda establecida y severa en la rata.