Study of the oxidative metabolic function and chemotaxis of neutrophils from patients with cancer influenced by selenium yeast.
The effects of Selenium Yeast (SY) given orally to patients with cancer on the oxidative metabolic function and chemotaxis of neutrophils were studied by Lumino-dependent Chemiluminescence (CL) assay and agarose plates assay, respectively. The results showed that the background CL and the peak value CL of neutrophils from patients with cancer 14 d after taking SY were, on the average, 4 and 1.2 times higher than those before taking SY. The chemotactic index (CI) and chemotactic differential (CD) increased in response to SY supplementation; the differences are statistically significant (p less than 0.01), and no corresponding differences could be seen in the control group (taking yeast).
Xu
H B
HB
Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Mei
W D
WD
Dong
Z M
ZM
Liao
B L
BL
D000328:Adult; D000368:Aged; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008165:Luminol; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D012643:Selenium / Q000494:pharmacology*; D015003:Yeasts
D008165:Luminol; D012643:Selenium