RNA elongation by RNA polymerase II is not inhibited by N-ethylmaleimide or iodoacetamide.
The elongation of RNA by RNA polymerase II is not inhibited by N-ethylmaleimide or iodoacetamide. Three systems were studied: a soluble chromatin, purified RNA polymerase II with DNA, and a HeLa cell extract with an adenovirus 2 promoter sequence.
Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267-0524.
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Krueger
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D001483:Base Sequence; D002843:Chromatin / Q000201:enzymology; D004247:DNA / Q000235:genetics; D005033:Ethylmaleimide / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007460:Iodoacetamide / Q000494:pharmacology*; D007461:Iodoacetates / Q000494:pharmacology*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012313:RNA / Q000096:biosynthesis*; D012319:RNA Polymerase II / Q000378:metabolism*; D011817:Rabbits; D014158:Transcription, Genetic / Q000187:drug effects
D002843:Chromatin; D007461:Iodoacetates; D012313:RNA; D004247:DNA; D012319:RNA Polymerase II; D005033:Ethylmaleimide; D007460:Iodoacetamide