[Age-related features of the effects of alpha- and beta-adrenomimetics on the glucocorticoid function of the adrenal glands].
In vitro effect of alpha-adrenomimetic naphtizin (0.1 mM X 1(-1) and beta-adrenomimetic isoproterenol (10 mcM X 1(-1) on the basal and ACTH-stimulated (10 U X 1(-1) production of II-oxoketosteroids (II-OKS) by isolated adrenals (IA) was studied in adult (6 mo) and old (28 mo) male rats. Naphtizin increased ACTH-stimulated secretion of II-OKS by IA of adult rats, but had no effect on the above secretion of old rats. Isoproterenol enhanced basal secretion of II-OKS by adult IA. No such effect on IA was found in old rats. There was no additive effect of isoproterenol on ACTH-stimulated II-OKS secretion by IA in both age groups.
E N
EN
Gorban'
D000311:Adrenal Glands / Q000187:drug effects* / Q000502:physiology; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D005938:Glucocorticoids / Q000502:physiology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009278:Naphazoline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D005938:Glucocorticoids; D009278:Naphazoline; D007545:Isoproterenol
Vozrastnye osobennosti vliianiia alfa- i beta-adrenomimetikov na gliukokortikoidnuiu funktsiiu nadpochechnikov.