[Bayesian and RFLP linkage analysis on a DMD family].
Three methods were applied to estimate the carrier risk of the daughter of an obligate carrier of the Duchenne gene in a pedigree of Duchenne muscular dystrophy (DMD). According to Mendel's law of segregation, the daughter (III-3) of the obligate carrier (II-2) has a 50% chance of being a carrier. III-3 is also found to have a normal value in a carrier test, creatine phosphate kinase (CPK), and so the Bayesian analysis in risk estimation shows that the posterior probability that she is a carrier (25%). The restriction fragment length polymorphism (RFLP) linkage analysis indicates that the probability that III-3 is a carrier less than 5%. This result can be included in the Bayesian analysis to give an even lower risk of less than 2%. Our study demonstrates that the best result of carrier risk estimation can be obtained by a simultaneous application of Mendel's law, RFLP linkage analysis and the Bayesian analysis.
Gao
Y Z
YZ
Department of Biology, Nanjing Railway Medical College.
Li
M F
MF
Zhang
Z P
ZP
Zhang
Q
Q
Zhang
L S
LS
Wang
S J
SJ
D001499:Bayes Theorem; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length