[Angiogenic activity of mononuclear cells in the peripheral blood of patients with ischemic heart disease].
In the paper the cell-mediated phase of the immune response was assessed in ischaemic heart disease (IHD). The assessment was based on the angiogenesis test in which new capillaries are formed from the already existing vascularization. The process is mediated by mononuclear cells from peripheral blood, and is induced by degradation products appearing as a result of ischaemic injury to the tissues. The test was carried out in 71 patients with IHD and in 65 clinically healthy subjects. A significant fall was demonstrated of the angiogenic activity of mononuclear cells isolated from the peripheral blood of IHD patients as compared with controls (p less than 0.001). No effect was method of disease duration, its form or treatment on angiogenesis. The obtained results may suggest a failure of the immune system competent in this process in IHD. Perhaps this is related to a special form of IHD.
Katedry i Kliniki Kardiologii II Wydziału Lekarskiego Ak. Med., Warszawie.
M
M
Pawińska
I
I
Laniewska
M
M
Sztorc
J
J
Syska
T
T
Wróblewski
J
J
Kuch
D000328:Adult; D000368:Aged; D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007963:Leukocytes, Mononuclear / Q000502:physiology*; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000503:physiopathology*
Aktywność angiogenna komórek jednojadrzastych krwi obwodowej pacjentów z choroba niedokrwienna serca (ChNS).