Conditions required for the bactericidal activity of fleroxacin and pefloxacin against Escherichia coli KL 16.
Pefloxacin and fleroxacin showed biphasic bactericidal activity against Escherichia coli KL16 in nutrient broth. Bacteriostatic concentrations of chloramphenicol, an inhibitor of protein synthesis, and rifampicin, an inhibitor of RNA synthesis, could not completely abolish the bactericidal activity of either drug. Pefloxacin and fleroxacin were also active against non-dividing E. coli KL16. Therefore, pefloxacin and fleroxacin are able to kill bacteria which are not dividing nor actively synthesising protein or RNA.
Lewin
C S
CS
Department of Bacteriology, Medical School, University of Edinburgh.
Amyes
S G
SG
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000187:drug effects; D002701:Chloramphenicol / Q000494:pharmacology; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D016576:Fleroxacin; D015366:Pefloxacin / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D012293:Rifampin / Q000494:pharmacology
D000890:Anti-Infective Agents; D001426:Bacterial Proteins; D012329:RNA, Bacterial; D015366:Pefloxacin; D002939:Ciprofloxacin; D002701:Chloramphenicol; D016576:Fleroxacin; D012293:Rifampin