In vitro evaluation of the pollen extract, cernitin T-60, in the regulation of prostate cell growth.
Nine human-derived cancer and non-cancer continuous cell lines were employed to evaluate the relative in vitro activity of the pollen extract, Cernitin T-60. Responses of the cell lines to the drug were assessed by measuring growth and cell survival as determined by cell count. The results demonstrated that of the 9 continuous cell lines tested, only those derived from the human prostate were growth inhibited by the pollen extract, whereas the non-prostate derived cells exhibited variable degrees of resistance to the T-60. The selectivity of the drug for the prostate cell lines was even more pronounced in the hormone-independent models, suggesting that there might be a place for the pollen extract in the control of abnormal growth in hormone-insensitive cells.
University Department of Surgery (WGH), Western General Hospital, Edinburgh.
F K
FK
Habib
M
M
Ross
A C
AC
Buck
L
L
Ebeling
A
A
Lewenstein
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010936:Plant Extracts; D011058:Pollen; D011467:Prostate / Q000166:cytology / Q000187:drug effects*; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy; D012434:Secale; D014407:Tumor Cells, Cultured / Q000187:drug effects
D010936:Plant Extracts; C010070:cernilton; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase