[The role of delta-sleep-inducing peptide in the normalization of cardiac electric stability in experimental emotional stress].
In chronic experiments on rabbits, a delta-sleeping inducing peptide was tested for effects on the cardiac electric stability and onset of ventricular premature beats during experimental emotional stress. The peptide in a dose of 60 nm/kg was found to normalize the thresholds of ventricular fibrillation and its predictors and to decrease or abolish spontaneous ventricular premature beats occurring during the stress. This suggests that the delta-sleep-inducing peptide may be used to prevent cardiac arrhythmias during stresses.
Ul'ianinskiĭ
L S
LS
Zviagintseva
M A
MA
Arkhangel'skaia
M I
MI
D000818:Animals; D000889:Anti-Arrhythmia Agents; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D003701:Delta Sleep-Inducing Peptide / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D011602:Psychophysiologic Disorders / Q000188:drug therapy* / Q000209:etiology; D011817:Rabbits; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000150:complications*; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology
D000889:Anti-Arrhythmia Agents; D003701:Delta Sleep-Inducing Peptide
Rol' peptida delta-sna v normalizatsii elektricheskoĭ stabil'nosti serdtsa pri éksperimental'nom émotsional'nom stresse.