[The effect of copper on the metabolism of iodine, carbohydrates and proteins in rats].
Experiments on 156 rats maintained at ration with copper deficiency have demonstrated a decrease in the values of iodine metabolism in organs and tissues excluding the liver where a sharp increase in the concentration and content of inorganic iodine was observed. A disturbance in indices of carbohydrate and proteins metabolism in the organism of animals is marked. A direct relationship with a correlation coefficient equaling 0.87-1.00 is determined between changes in the concentration of protein-bound iodine in blood and concentration of glycogen in the liver, skeletal muscles, albumins, alpha 1-, alpha 2-globulins, urea concentration; an inverse relationship with glucose, activity of blood lipo-dehydrogenase and liver mitochondria, aldolase, concentration of pyruvic and lactic acids is established as well. It is concluded that copper deficiency can exert both a direct effect on metabolic processes (as data from literature testify) and an indirect one disturbing iodine metabolism, i. e. sharply decreasing protein-bound iodine production by the thyroid gland.
Esipenko
B E
BE
Marsakova
N V
NV
D000818:Animals; D050260:Carbohydrate Metabolism; D003300:Copper / Q000172:deficiency*; D007455:Iodine / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D013960:Thyroid Function Tests
D011506:Proteins; D003300:Copper; D007455:Iodine
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