[Ventricular arrhythmia and late potentials in patients with hypertrophic cardiomyopathy].
Holter monitoring (48 h) and registration of signal-averaged late potentials (method of Simson, high pass filter 40 Hz) were performed in outpatiens with hypertrophic cardiomyopathy. A prevalence of spontaneous ventricular arrhythmias could be determined in 51 patients; the results of 45 patients not taking antiarrhythmic drugs are presented here. 96% of these showed ventricular premature beats, 76% had multiform extrasystoles, 27% showed pairs of ectopic beats and 20% had runs of ventricular tachycardia (more than 3 QRS complexes). Absolute counts of premature beats were low in most patients, but important interindividual differences could be observed: M = 34 extrasystoles/24 h (0-4943). Ventricular tachycardias were of short duration (maximum 11 QRS) with heart rate ranging from 120 to 200/min. All patients were asymptomatic during tachycardia. Signal-averaged late potentials could be registered in 30 patients, 28 of them without antiarrhythmic drug therapy. Mean QRS duration (QRSdur) was 108 +/- 12 ms, mean duration of low amplitude signals (less than 40 microV) in the terminal portion of the QRS (LAdur) was 27 +/- 13 ms, and mean amplitude of the last 40 ms of the filtered QRS (LAamp) was 65 +/- 43 microV. A patient was considered to show late potentials if two of the following criteria were present: QRSdur greater than 120 ms, LAdur greater than or equal to 40 ms, LAamp less than 20 microV. This was found in four patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Medizinische Universitätsklinik Göttingen, Abteilung Kardologie und Pulmonologie.
C
C
Fleischmann
B D
BD
Gonska
S
S
Brune
G
G
Sold
H
H
Kreuzer
D000328:Adult; D000368:Aged; D002037:Bundle-Branch Block / Q000175:diagnosis; D005117:Cardiac Complexes, Premature / Q000175:diagnosis; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis* / Q000503:physiopathology; D003645:Death, Sudden / Q000209:etiology; D015716:Electrocardiography, Ambulatory / Q000295:instrumentation*; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012815:Signal Processing, Computer-Assisted; D013610:Tachycardia / Q000175:diagnosis* / Q000503:physiopathology
Ventrikuläre Rhythmusstörungen und Spätpotentiale bei Patienten mit hypertropher Kardiomyopathie.