Fetotoxicity of hexachlorocyclohexane (HCH) in mice: morphological, biochemical and residue evaluations.
Administration of single po doses of technical hexachlorocyclohexane (HCH) (5, 25, 50, 100 or 200 mg/kg) to mice on day 9 of gestation caused dose-related toxic effects in the fetuses. HCH-treated dams had consistent decreases. The percent resorption and the number of live fetuses/dam indicated that high concentrations of HCH trigger fetotoxic effects. Enzymatic changes in the livers of control and HCH-treated groups showed significant alterations. Accumulation of HCH was in the fatty tissue, brain, liver and blood.
Industrial Toxicology Research Centre, Mahatama Gandhi Marg, Lucknow, India.
T S
TS
Dikshith
M K
MK
Srivastava
R B
RB
Raizada
D000273:Adipose Tissue / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000493:pharmacokinetics / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens / Q000493:pharmacokinetics / Q000633:toxicity
D013723:Teratogens; D001556:Hexachlorocyclohexane; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase