The relationship of prostaglandins to cAMP, IgG, IgM and alpha-2-macroglobulin in gingival crevicular fluid in chronic adult periodontitis.
Gingival crevicular fluid, collected from 8 patients with chronic adult periodontitis before and 21 days after root planing and scaling, was analysed for prostaglandin E2, 6KPGF1 alpha, cAMP, IgG, IgM and alpha-2-macroglobulin, and their inter-relationship evaluated. There was a significant decrease in the levels of prostaglandin E2, IgG, IgM and alpha-2-macroglobulin after treatment, whereas the levels of 6KPGF1 alpha and cAMP remained essentially unchanged. The level of prostaglandin E2 decreased by 35%, IgG by 32%, IgM by 90%, and alpha-2-macroglobulin by 79%. There was a significant degree of correlation between prostaglandin E2 and 6KPGF1 alpha and cAMP before treatment but not after, but no correlation between prostaglandin E2 and IgG, IgM and alpha-2-macroglobulin either before or after. This correlation pattern indicates the involvement of E2, prostaglandin 6KPGF1 alpha and cAMP in inflammation in the periodontium. The changes in IgG, IgM and alpha-2-macroglobulin reflect yet another mechanism of host response which appears to be independent of prostaglandins.
Sengupta
S
S
Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103.
Fine
J
J
Wu-Wang
C Y
CY
Gordon
J
J
Murty
V L
VL
Slomiany
A
A
Slomiany
B L
BL
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis*; D000328:Adult; D002908:Chronic Disease; D000242:Cyclic AMP / Q000032:analysis*; D012534:Dental Scaling; D015232:Dinoprostone / Q000032:analysis*; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000201:enzymology / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D010518:Periodontitis / Q000201:enzymology / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D014092:Tooth Root / Q000601:surgery; D000511:alpha-Macroglobulins / Q000032:analysis*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000511:alpha-Macroglobulins; D015121:6-Ketoprostaglandin F1 alpha; D000242:Cyclic AMP; D015232:Dinoprostone