Variation in T-lymphocyte activation and susceptibility to SIVPBj-14-induced acute death in macaques.
In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate, only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys, unlike rhesus, have reduced CD4/CD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death.
Henry M. Jackson Foundation Research Laboratory, Rockville, MD 20850.
Y J
YJ
Rosenberg
B D
BD
White
S F
SF
Papermaster
P
P
Zack
P B
PB
Jarling
G A
GA
Eddy
D S
DS
Burke
M G
MG
Lewis
D000208:Acute Disease; D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004198:Disease Susceptibility; D006649:Histocompatibility Antigens / Q000096:biosynthesis; D017493:Leukocyte Common Antigens; D008213:Lymphocyte Activation; D008251:Macaca; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008254:Macaca nemestrina; D010641:Phenotype; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000401:mortality; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015703:Antigens, CD; D006649:Histocompatibility Antigens; D017493:Leukocyte Common Antigens