[Presence and functional role of an epitope of the second receptor for IgE (FcE RII) in mast cells and basophils in the rat].
Mast cells and basophils express the high affinity IgE receptor (FcERI) whereas the low affinity receptor for monomeric IgE (FcE RII) is present on macrophages, lymphocytes, eosinophils, platelets and Langerhans cells. Recent studies confirmed that the two receptors were totally distinct. The present work shows that a monoclonal antibody (BB10), able to bind to FcE RII on different cell populations, interacts with FcE RI expressing cells: rat peritoneal mast cells and a rat basophilic leukemia cell line (RBL 2 H 3). The structure recognized by BB10 is distinct from FcE RI and modulates the IgE-dependent histamine release. In conclusion, it appears that a common epitope with FcE RII is present on mast cells and basophils and that a functional relation might exist between this structure and FcE RI.
Centre d'Immunologie et de Biologie parasitaire, Unité mixte I.N.S.E.R.M. U n. 167, Lille.
A
A
Tournoys
M
M
Capron
J P
JP
Papin
J P
JP
Kusnierz
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A
Capron
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D001491:Basophils / Q000276:immunology*; D000939:Epitopes / Q000032:analysis* / Q000276:immunology; D005434:Flow Cytometry; D006636:Histamine Release / Q000276:immunology; D008407:Mast Cells / Q000276:immunology*; D051381:Rats; D011961:Receptors, Fc / Q000276:immunology*; D017455:Receptors, IgE
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D000939:Epitopes; D011961:Receptors, Fc; D017455:Receptors, IgE
Présence et rôle fonctionnel d'un épitope du second récepteur pour l'IgE (FcE RII) sur les mastocytes et les basophiles de rat.