An asymptomatic, normotensive sipple syndrome patient with glucose intolerance and hypercholesterolemia, and her kindred.
The proband, a 42-year-old woman without any symptoms or hypertension, was admitted for examination of accidentally discovered bilateral adrenal masses. Physical examination disclosed bilateral nodular goiter and mild sinus tachycardia. Pheochromocytomas and medullary thyroid carcinomas were revealed by biochemical and histopathological examinations. Hypercholesterolemia and abnormal glucose metabolism returned to normal after bilateral total adrenalectomy and thyroidectomy. Screening examination showed four affected family members. Three of them were also asymptomatic and normotensive. In pheochromocytoma patients, normotension, hypercholesterolemia, and impaired glucose metabolism might be signs of excess secretion of epinephrine rather than norepinephrine.
Department of Internal Medicine, Fukui Prefectural Hospital, Japan.
T
T
Wakasugi
T
T
Aoyama
J
J
Hirai
T
T
Saga
D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002272:Carcinoembryonic Antigen / Q000097:blood; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D002648:Child; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D010375:Pedigree; D010673:Pheochromocytoma / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D013964:Thyroid Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000235:genetics
D014408:Biomarkers, Tumor; D001786:Blood Glucose; D002272:Carcinoembryonic Antigen; D007328:Insulin; D004837:Epinephrine