Neurotoxicity of 1-methoxycycloheptatriene--a Purkinje cell toxicant.
The toxicity of 1-methoxycycloheptatriene (1-MCHT), a sensory irritant, has been investigated in beagles. It was found to produce gross inco-ordination of the limbs at intravenous doses greater than 10 mg kg-1. The main histological abnormalities were in the cerebellum and consisted of Purkinje cell death and subsequent reactive gliosis. A few necrotic neurons were seen in the diencephalon, pons and medulla. Haematological abnormalities, e.g. leucocytosis with relative lymphopenia, were seen, while biochemical changes included hyperglycaemia and a rise in plasma aminotransferases. The no-effect dose for the histological and biochemical changes was the same. These abnormalities are compared with cerebellar changes observed in acrylamide and other toxic states.
Marrs
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Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire, UK.
Allen
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Colgrave
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McConnell
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R
D000818:Animals; D001774:Blood Chemical Analysis; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003508:Cycloheptanes / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006403:Hematologic Tests; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D011689:Purkinje Cells / Q000187:drug effects* / Q000473:pathology
D003508:Cycloheptanes; C064256:1-methoxy-1,3,5-cycloheptatriene