Strain difference in phenylethanolamine N-methyltransferase activity and immunoreactivity of medulla oblongata of Sprague-Dawley and Long-Evans hooded rats.
Previously, we reported that retinal phenylethanolamine N-methyltransferase (PNMT) activity of Sprague-Dawley (SD) rats was significantly higher than that of Long-Evans (LE) hooded rats. However, there were no noticeable differences observed in PNMT-immunostaining patterns between the retinae of LE and SD rats. In order to examine this discrepancy, we extended this study to areas of the medulla oblongata harboring PNMT-containing cell bodies. In the present report, we demonstrate that the enzyme activity as well as the immunoreactivity of PNMT in medulla oblongata of SD rats were significantly higher than that observed in the LE strain.
Laboratory of Molecular Neurobiology, Cornell University Medical College, Burke Rehabilitation Center, White Plains, NY 10605.
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Park
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Park
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Joh
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Anwar
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Ruggiero
D000818:Animals; D006651:Histocytochemistry; D066298:In Vitro Techniques; D008526:Medulla Oblongata / Q000166:cytology / Q000201:enzymology*; D010625:Phenylethanolamine N-Methyltransferase / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D014446:Tyrosine 3-Monooxygenase; D010625:Phenylethanolamine N-Methyltransferase