Study of a restriction fragment length polymorphism for serum amyloid P gene in rheumatoid arthritis with amyloidosis.
Amyloidosis is a severe complication of rheumatoid arthritis (RA). A restriction fragment length polymorphism (RFLP) using MspI for the serum amyloid P gene was recently found to be associated with amyloidosis in juvenile arthritis. The aim of our study was to determine whether this RFLP could serve as a genetic marker for the development of secondary amyloidosis in RA. The prevalence of this marker was determined in 4 groups of patients: patients with amyloidosis secondary to RA; with amyloidosis secondary to various diseases excluding RA; with RA but without amyloidosis; adult controls without any known disease related to reactive amyloidosis. No significant differences were seen between these 4 groups with relation to this polymorphism, so that it cannot serve as a genetic marker for amyloidosis complicating RA in our population.
Département de Médecine Interne, Hôpital Cochin, Paris, France.
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G
Grateau
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M
Baudis
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M
Delpech
D000686:Amyloidosis / Q000209:etiology / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000235:genetics*; D015139:Blotting, Southern; D005819:Genetic Markers; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D000683:Serum Amyloid P-Component / Q000235:genetics*
D005819:Genetic Markers; D000683:Serum Amyloid P-Component