Effects of topical flurbiprofen on the intraocular pressure lowering effects of apraclonidine and timolol.
We performed a prospective study that evaluated whether pretreatment with topical flurbiprofen alters the intraocular pressure (IOP) lowering effects of either topical 1% apraclonidine hydrochloride or 0.5% timolol maleate. Eighteen normal volunteers participated in this six-armed, randomized, double-masked, crossover study. All subjects received the first study medication, either bilateral 0.3% flurbiprofen or placebo (its vehicle), every 30 minutes for four applications. They next received the second study medication: either 0.5% timolol maleate (Timoptic), 1% apraclonidine hydrochloride, or placebo in both eyes. We measured IOP before the instillation of the first study medication and the second study medication (baseline), and then at 1, 3, and 6 hours later. All subjects underwent all six treatment arms. Flurbiprofen alone had no effect on IOP. Maximum IOP lowering occurred between 3 and 6 hours after timolol and apraclonidine administration. There was no difference in IOP lowering between timolol- and apraclonidine-treated eyes. Pretreatment with flurbiprofen did not affect the IOP lowering that was obtained with timolol or apraclonidine administration.
Sulewski
M E
ME
Glaucoma Services, Greater Baltimore, Medical Center, MD.
Robin
A L
AL
Cummings
H L
HL
Arkin
L M
LM
D000287:Administration, Topical; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000328:Adult; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D013999:Timolol / Q000494:pharmacology*
D000316:Adrenergic alpha-Agonists; D005480:Flurbiprofen; D013999:Timolol; C016986:apraclonidine; D003000:Clonidine