Neurotoxicity of 1-methoxycycloheptatriene--a Purkinje cell toxicant.
The toxicity of 1-methoxycycloheptatriene (1-MCHT), a sensory irritant, has been investigated in beagles. It was found to produce gross inco-ordination of the limbs at intravenous doses greater than 10 mg kg-1. The main histological abnormalities were in the cerebellum and consisted of Purkinje cell death and subsequent reactive gliosis. A few necrotic neurons were seen in the diencephalon, pons and medulla. Haematological abnormalities, e.g. leucocytosis with relative lymphopenia, were seen, while biochemical changes included hyperglycaemia and a rise in plasma aminotransferases. The no-effect dose for the histological and biochemical changes was the same. These abnormalities are compared with cerebellar changes observed in acrylamide and other toxic states.
Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire, UK.
T C
TC
Marrs
I V
IV
Allen
H F
HF
Colgrave
R
R
McConnell
D000818:Animals; D001774:Blood Chemical Analysis; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003508:Cycloheptanes / Q000633:toxicity*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006403:Hematologic Tests; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D011689:Purkinje Cells / Q000187:drug effects* / Q000473:pathology
D003508:Cycloheptanes; C064256:1-methoxy-1,3,5-cycloheptatriene