Microinjection of S-nitrosocysteine into the nucleus tractus solitarii decreases arterial pressure and heart rate via activation of soluble guanylate cyclase.
Lewis
S J
SJ
Department of Pharmacology, University of Iowa, Iowa City 52242.
Ohta
H
H
Machado
B
B
Bates
J N
JN
Talman
W T
WT
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003545:Cysteine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D003864:Depression, Chemical; D004789:Enzyme Activation / Q000187:drug effects; D006162:Guanylate Cyclase / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D008526:Medulla Oblongata; D008751:Methylene Blue / Q000494:pharmacology; D008845:Microinjections; D009475:Neurons, Afferent / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D026403:S-Nitrosothiols
D026403:S-Nitrosothiols; C021315:S-nitrosocysteine; D006162:Guanylate Cyclase; D003545:Cysteine; D008751:Methylene Blue