The oncofetal gene Pem specifies a divergent paired class homeodomain.
The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. The Pem recognition helix also has an isoleucine residue replacing an invariant asparagine residue and shares an asparagine residue at a third position with two other vertebrate homeoproteins, at least one of which binds to DNA only as a dimer.
Miami University, Department of Zoology, Oxford, Ohio 45056.
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D000595:Amino Acid Sequence; D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D001483:Base Sequence; D004273:DNA, Neoplasm / Q000302:isolation & purification; D004330:Drosophila / Q000254:growth & development; D005801:Genes, Homeobox; D008969:Molecular Sequence Data; D009857:Oncogenes; D016415:Sequence Alignment
D000951:Antigens, Neoplasm; D004273:DNA, Neoplasm; C031192:oncofetal antigens