Adjunctive clonazepam in the treatment of chronic schizophrenia.
Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features. Manic symptoms improved but returned following discontinuation of clonazepam. The drug appears to benefit positive psychotic symptoms but worsens negative symptoms.
Herrera
J M
JM
Mount Sinai School of Medicine, Elmhurst Hospital Center, N.Y.
Alvarez
W A
WA
Freinhar
J P
JP
Lawson
W B
WB
Sramek
J J
JJ
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D002998:Clonazepam / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016037:Single-Blind Method
D014150:Antipsychotic Agents; D002998:Clonazepam