Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma.
A prospective study analysed the prognostic value of nm23-H1 allelic deletions in colorectal cancer. Of 21 patients with no evidence of distant metastases at initial operation, 11 showed nm23-H1 allelic deletions (including 1 homozygous deletion); 10 had no nm23-H1 deletions. After median follow-up of 25 months, distant metastases had developed in 8 of 11 (73%) patients with nm23-H1 deletions but in only 2 of 10 (20%) without nm23-H1 deletions (p less than 0.03). Tests with probe YNZ 22.1, near p53, showed no significant association with distant metastases. nm23-H1 may be, or may be located near, a late-acting suppressor gene in colorectal carcinoma, in which deletions may have prognostic value.
Cohn
K H
KH
Department of Surgery, State University of New York Health Science Center, Brooklyn.
Wang
F S
FS
Desoto-LaPaix
F
F
Solomon
W B
WB
Patterson
L G
LG
Arnold
M R
MR
Weimar
J
J
Feldman
J G
JG
Levy
A T
AT
Leone
A
A
D000368:Aged; D000483:Alleles; D002872:Chromosome Deletion; D015179:Colorectal Neoplasms / Q000235:genetics*; D015342:DNA Probes; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000235:genetics*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies
D015342:DNA Probes