[Physiopathology of pertussis encephalopathy. Prophylaxis. Pathogenesis of the "reaction" against intramuscular pertussis vaccine. Vaccination with "shield"].
The specific local and humoral immunological situation of the child, by permitting or not (+/- specific IgA-S) the passage of the Bordetella toxins to the bloodstream and the formation or not (+/- specific circulating IgG) of Circulating Immune Complexes (CIC), brings back to Type III Immunoreactions the pathogenesis of the pertussis encephalopathy and the reactions provoked by intramuscular vaccine. Since the antihistaminics and antiserotoninics can prevent the CIC precipitation, the Author believes that this would imply the indication to the usage of antihistaminics or antiserotoninics to prevent bot the neurologic complications of the illness and the systemic reactions to the intramuscular vaccine.
Fiore
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D000936:Antigen-Antibody Complex / Q000097:blood; D004673:Encephalomyelitis, Acute Disseminated / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007273:Injections, Intramuscular; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology
D000936:Antigen-Antibody Complex; D010567:Pertussis Vaccine
Fisiopatologia dell'encefalopatia pertussica. Profilassi. Patogenesi delle "reazioni" da vaccino antipertosse intramuscolo. Vaccinazione con "copertura".