Salivary excretion of mexiletine in normal healthy volunteers.
To investigate the kinetics and correlation between serum and saliva levels of mexiletine, serum (total and unbound) and saliva drug concentration-time courses have been analysed in five normal healthy volunteers after administration of a single oral dose (200 mg) of the drug. Mexiletine levels in saliva were always higher than those in serum. The drug concentration-time curve in each sample was analysed according to the non-linear least squares regression program MULTI, for a two-compartment model with first-order absorption. The saliva drug concentration in the post-absorption phase was found to be well correlated with either corresponding serum total or serum unbound drug level in four of the subjects. Although there was a large inter-individual variation in the ratio of saliva to serum drug concentrations as well as in the pharmacokinetic parameters, an almost consistent ratio was obtained in each individual.
Katagiri
Y
Y
Department of Pharmacy, Shimane Medical University Hospital, Izumo, Japan.
Nagasako
S
S
Hayashibara
M
M
Iwamoto
K
K
D000284:Administration, Oral; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000097:blood / Q000302:isolation & purification / Q000493:pharmacokinetics*; D012463:Saliva / Q000737:chemistry*
D008801:Mexiletine