The promise of colony-stimulating factors in clinical practice.
Colony-stimulating factors (CSFs) are a class of glycoprotein hormones that stimulate production of the cellular elements of blood. Two of these hormones, granulocyte macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), have shown promise in clinical trials for the treatment of various neutropenic states. This article reviews the published experience in treating patients with GM-CSF and G-CSF and points out potential applications of these drugs in clinical practice.
J A
JA
Glaspy
J M
JM
Ambersley
D000380:Agranulocytosis / Q000628:therapy*; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D003115:Colony-Stimulating Factors / Q000627:therapeutic use*; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D006098:Granulocytes / Q000276:immunology; D006133:Growth Substances / Q000627:therapeutic use; D006801:Humans; D007970:Leukopenia / Q000628:therapy; D009503:Neutropenia / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
D003115:Colony-Stimulating Factors; D006133:Growth Substances; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor