Continuous delivery of colchicine in the rat brain with osmotic pumps for inhibition of rabies virus transport.
Rabies virus is a neurotropic agent which spreads in the CNS via axonal transport. Previous studies had shown that this axonal transport through the brain could be inhibited by stereotaxic administration of colchicine; however, this inhibition was reversible. We describe here a method to enhance the duration of this colchicine-mediated inhibition by delivering the drug continuously in the rat brain with osmotic pumps.
Rabies Unit, Pasteur Institute, Paris, France.
P E
PE
Ceccaldi
A
A
Ermine
H
H
Tsiang
D000818:Animals; D001370:Axonal Transport / Q000187:drug effects; D001921:Brain / Q000382:microbiology*; D003078:Colchicine / Q000008:administration & dosage* / Q000627:therapeutic use; D015918:Infusion Pumps, Implantable; D008297:Male; D009997:Osmotic Pressure; D011818:Rabies / Q000188:drug therapy* / Q000382:microbiology; D011820:Rabies virus / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D003078:Colchicine