Estramustine binding protein in human benign prostatic hypertrophy.
Using a highly sensitive radioimmunoassay (RIA) of estramustine binding protein (EMBP) with the antibody raised against rat-EMBP, the concentration of EMBP in human benign prostatic hypertrophy (BPH) tissue was evaluated. Using mechanical separation procedure, EMBP was found significantly higher in the epithelium (10.7 ng/mg protein) than in the stroma (2.9 ng/mg protein). When human BPH was classified into glandular, fibromuscular and mixed type, the concentration of EMBP was the highest in glandular type (15.7 ng/mg protein) and the lowest in fibromuscular type (10.8 ng/mg protein).
Department of Urology, Shimane Medical University, Izumo-shi/Japan.
H
H
Shiina
M
M
Mizutani
T
T
Ishibe
D000906:Antibodies; D001667:Binding, Competitive; D002352:Carrier Proteins / Q000378:metabolism*; D004961:Estramustine / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D029584:Prostatic Secretory Proteins; D011863:Radioimmunoassay
D000906:Antibodies; D002352:Carrier Proteins; D029584:Prostatic Secretory Proteins; C028321:estramustine-binding protein; D004961:Estramustine