Chelation of postsynaptic Ca2+ facilitates long-term potentiation of hippocampal IPSPs.
In guinea pig hippocampal slices, a tetanic stimulation of the stratum radiatum caused long-term potentiation (LTP) of the excitatory postsynaptic potential (EPSP) but not of the GABAB receptor-mediated slow inhibitory postsynaptic potential (IPSP) in the CA1 neurons. In neurons in which Ca2+ was chelated with 1,2-bis(2-aminophenoxy) ethane N,N,N',N'-tetra-acetic acid (BAPTA) or ethylene-bis(oxyethylenenitrilo)tetra-acetic acid (EGTA), tetanic stimulation of the stratum radiatum caused LTP of the slow IPSP but not of the EPSP. These results indicate that a reciprocal relationship exists between LTP of the EPSP and LTP of the slow IPSP as far as the involvement of the postsynaptic Ca2+ is concerned.
Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.
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Morishita
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Sastry
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D000818:Animals; D002118:Calcium / Q000502:physiology*; D004533:Egtazic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D010852:Picrotoxin / Q000031:analogs & derivatives / Q000494:pharmacology; D011810:Quinoxalines / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000502:physiology*; D054830:Sesterterpenes
D015763:2-Amino-5-phosphonovalerate; D018750:6-Cyano-7-nitroquinoxaline-2,3-dione; D002118:Calcium; D004533:Egtazic Acid; D010852:Picrotoxin; D011810:Quinoxalines; D011963:Receptors, GABA-A; D054830:Sesterterpenes; C022961:picrotoxinin; C025603:1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid