Non-random association between DNA markers and Huntington disease locus in the Italian population.
A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43. This observation increases the number of loci in linkage disequilibrium with HD. However, the amount of disequilibrium does not allow either a finer localization of the HD gene or a substantial improvement in risk calculations.
Novelletto
A
A
Dipartimento di Biologia, Università Tor Vergata, Roma, Italy.
Mandich
P
P
Bellone
E
E
Malaspina
P
P
Vivona
G
G
Ajmar
F
F
Frontali
M
M
D000483:Alleles; D002894:Chromosomes, Human, Pair 4; D005787:Gene Frequency; D005819:Genetic Markers; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D007558:Italy; D015810:Linkage Disequilibrium; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers