Changes in arterial oxygen tension after gastric lavage for drug overdose.
1. Changes in arterial oxygen tension after gastric lavage were investigated in a prospective study of 55 patients admitted for drug overdose. 2. A significantly greater decrease was observed in smokers compared to non-smokers. 3. A correlation was found between the tricyclic antidepressant serum level and the observed oxygen tension decrease. 4. The usefulness, as well as the safety of the lavage procedure, in managing tricyclic antidepressants overdoses is controversial.
Jorens
P G
PG
Department of Internal Medicine and Intensive Care Medicine, Middelheim General Hospital, Antwerp, Belgium.
Joosens
E J
EJ
Nagler
J M
JM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D001158:Arteries; D004562:Electrocardiography; D005260:Female; D005751:Gastric Lavage / Q000009:adverse effects*; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011041:Poisoning / Q000453:epidemiology / Q000628:therapy; D011446:Prospective Studies
D000929:Antidepressive Agents, Tricyclic; D010100:Oxygen