The effects of electroconvulsive shock on catecholamine function in the locus ceruleus and hippocampus.
Repeated electroconvulsive shock (ECS) treatment (once per day for 7 days) produced a significant increase in tyrosine hydroxylase activity, GTP-cyclohydrolase activity and tetrahydrobiopterin (BH4) levels in the locus ceruleus and hippocampus from 1 to 4 days after the last treatment. These changes may be responsible for, or contribute to, the antidepressant effect of ECS treatment.
Department of Pharmacology, University of Colorado Health Sciences Center, Denver.
N
N
Weiner
M A
MA
Hossain
J M
JM
Masserano
D000818:Animals; D001708:Biopterins / Q000031:analogs & derivatives* / Q000378:metabolism; D004597:Electroshock; D006136:GTP Cyclohydrolase / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007700:Kinetics; D008125:Locus Coeruleus / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D001708:Biopterins; D014446:Tyrosine 3-Monooxygenase; D006136:GTP Cyclohydrolase; C003402:sapropterin