Malignant lymphomas in cynomolgus monkeys infected with simian immunodeficiency virus.
Malignant lymphomas were observed in 38% (9 of 24) of simian immunodeficiency virus (SIV)-infected cynomolgus monkeys (Macaca fascicularis) 5 to 15 months after inoculation with SIV strain SMM3. Lymphomagenesis in the SIV-infected monkeys was not related directly to the SIV-infectious dose given. All SIV-infected animals developed severe immunodeficiency. No significant difference in immunodeficiency was observed between tumor-bearing and non-tumor-bearing animals. In contrast, no lymphomas were observed in a comparable group of HIV-2-infected monkeys, which did not develop immunodeficiency; nor did the noninfected control monkeys. All 9 SIV-related tumors were high-grade B-cell lymphoblastic or pleomorphic lymphomas with extranodal, disseminated growth. Most tumors showed marked infiltration by monocytes and CD8+ T lymphocytes. Occasional tumor infiltrating cells showed immunohistochemical reaction for SIV. The cells of two tumors were established in vitro and shown to be of B-cell phenotype. The tumor cell cultures showed no reverse transcriptase activity and no evidence of virus infection by electron microscopy. Our observations indicate that SIV-induced immunodeficiency in cynomolgus monkeys also mimics HIV infection and AIDS in humans with regard to increased lymphomagenesis and type of lymphomas.
Immunopathology Laboratory, Karolinska Institute, Stockholm, Sweden.
H
H
Feichtinger
P
P
Putkonen
C
C
Parravicini
S L
SL
Li
E E
EE
Kaaya
D
D
Böttiger
G
G
Biberfeld
P
P
Biberfeld
D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D001402:B-Lymphocytes / Q000502:physiology*; D015704:CD4 Antigens / Q000032:analysis; D005260:Female; D007150:Immunohistochemistry / Q000379:methods; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000145:classification / Q000209:etiology* / Q000473:pathology; D008252:Macaca fascicularis; D008297:Male; D010641:Phenotype; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D013194:Staining and Labeling
D015703:Antigens, CD; D015704:CD4 Antigens