Cholesterol as a target for toxins.
A mechanism is proposed for the way in which cholesterol facilitates channel formation by polyene antibiotics and bacterial protein toxins. Central elements of the model are: (i) interactions between the ring system of the sterol and rigid elements of the polyene or toxin molecule, and (ii) the specific orientation of cholesterol within the membrane.
Centre for Biomembranes and Lipid Enzymology, University of Utrecht, NL.
B
B
de Kruijff
D000595:Amino Acid Sequence; D000666:Amphotericin B / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data
D001427:Bacterial Toxins; D007473:Ion Channels; D000666:Amphotericin B; D002784:Cholesterol