Radiation sensitization by an iodine-labelled DNA ligand.
An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand.
Martin
R F
RF
Molecular Sciences Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.
Murray
V
V
D'Cunha
G
G
Pardee
M
M
Kampouris
E
E
Haigh
A
A
Kelly
D P
DP
Hodgson
G S
GS
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D006690:Bisbenzimidazole / Q000031:analogs & derivatives / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D066298:In Vitro Techniques; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays
D001562:Benzimidazoles; D011838:Radiation-Sensitizing Agents; C064113:2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole; D004247:DNA; D006690:Bisbenzimidazole