Precocious expression of NAPA-73, an intermediate filament-associated protein, during nervous system and heart development in the chicken embryo.
A monoclonal antibody was generated, against early neural crest-derived cells, which recognizes an epitope present on a novel intermediate filament-associated protein. This protein has been named NAPA-73 and is expressed by progenitor cells of the nervous system and heart. Biochemical and ultrastructural studies indicate that this protein associates with bundles of intermediate filaments and therefore may play a role in the determination of cell shape.
Department of Cell Biology and Anatomy, Vollum Institute, Oregon Health Sciences University, Portland 97201.
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002642:Chick Embryo; D000939:Epitopes / Q000276:immunology; D006321:Heart / Q000196:embryology*; D007381:Intermediate Filament Proteins / Q000276:immunology / Q000378:metabolism*; D007382:Intermediate Filaments / Q000648:ultrastructure; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D009432:Neural Crest / Q000196:embryology* / Q000378:metabolism / Q000648:ultrastructure; D016900:Neurofilament Proteins
D000911:Antibodies, Monoclonal; D000939:Epitopes; D007381:Intermediate Filament Proteins; D016900:Neurofilament Proteins