Differential susceptibility of a rat glioma cell line and its clones to herpes simplex virus types 1 and 2.
A rat glioma cell line, C6-BU-1, showed differential susceptibility to herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), namely, all the HSV-1 strains tested so far persisted in this cell line but the HSV-2 strains did not. Two clones were derived from C6-BU-1 cells and designated C-17 and C-72. The C-72 as well as the parental C6-BU-1 cells supported the replication of HSV-1, but not that of HSV-2. In contrast, C-17 was highly resistant to both HSV-1 and HSV-2. Hydrocortisone treatment converted C-17 to being susceptible to HSV-1, but not to HSV-2. Therefore, C6-BU-1 cells consist of subpopulations heterogeneous in susceptibility to HSV-1 which may be possibly interchangeable.
Department of Microbiology, Miyazaki Medical College, Kihara, Japan.
K
K
Sakihama
Y
Y
Eizuru
Y
Y
Minamishima
D000818:Animals; D002461:Cell Line, Transformed; D002999:Clone Cells / Q000382:microbiology; D004198:Disease Susceptibility; D005910:Glioma / Q000188:drug therapy / Q000382:microbiology*; D006854:Hydrocortisone / Q000494:pharmacology; D051381:Rats; D018139:Simplexvirus / Q000187:drug effects / Q000254:growth & development*; D014779:Virus Replication / Q000187:drug effects
D006854:Hydrocortisone