Effects of combined exposure to aluminium and ethanol on aluminium body burden and some neuronal, hepatic and haematopoietic biochemical variables in the rat.
The effects of the daily administration of aluminium (25 mg kg-1, orally), ethanol (10% v/v, in drinking water) or both to adult rats, for 6 weeks, on the amount of aluminium present in the tissues and the functioning of brain biogenic amines, hepatic and serum transaminases and some haematopoietic variables were investigated. Ethanol alone was seen to inhibit the activity of delta-aminolevulinic acid dehydratase (ALAD), while aluminium alone elevated the activity of blood ALAD. However, aluminium and ethanol combined produced a more pronounced inhibition of blood ALAD and hepatic glutamic pyruvic transaminase (GPT) than either aluminium or ethanol alone. Simultaneous exposure to aluminium and ethanol also produced a significant elevation in urinary delta-aminolevulinic acid (ALA) blood zinc protoporphyrin (ZPP), serum glutamic oxaloacetic transaminase (GOT) and brain homovanillic acid (HVA), and a depletion in brain dopamine (DA) and 5-hydroxytryptamine (5-HT) levels, when compared to rats given aluminium alone. The concentration of aluminium in the blood and liver was significantly higher in rats exposed to both aluminium and ethanol than in those exposed to aluminium alone. Thus the consumption of alcohol may increase the rat's susceptibility to certain effects of aluminium.
Defence Research & Development Establishment, Gwalior, India.
S J
SJ
Flora
M
M
Dhawan
S K
SK
Tandon
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000187:drug effects; D000535:Aluminum / Q000493:pharmacokinetics / Q000633:toxicity*; D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects; D015306:Biogenic Monoamines / Q000378:metabolism; D001822:Body Burden; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D006413:Hematopoietic System / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D000623:Porphobilinogen Synthase / Q000097:blood; D011524:Protoporphyrins / Q000097:blood; D051381:Rats; D014018:Tissue Distribution
D015306:Biogenic Monoamines; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D000431:Ethanol; D000622:Aminolevulinic Acid; D000535:Aluminum; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000623:Porphobilinogen Synthase