Xenobiotic metabolizing enzymes in rainbow trout exposed to river water.
1. Juvenile rainbow trout were exposed to river water in a flow-through system. After 15 days of exposure, hepatic biotransformation activities and related parameters were measured and compared to those of the control group organisms that were maintained in tap water under identical experimental conditions. 2. Liver somatic index (LSI), microsomal protein and cytochrome P-450 contents, benzo[a]pyrene hydroxylase (AHH), ethoxyresorufin-O-deethylase (EROD) and UDP glucuronyl transferase activities were not significantly affected. 3. Aminopyrine-N-demethylase (APD) activity showed a slight yet significant increase in exposed trout.
Water Research Institute, CNR, Milan, Italy.
L
L
Viganó
A
A
Arillo
M
M
Bagnasco
F
F
Melodia
S
S
Galassi
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D004784:Environmental Monitoring / Q000379:methods*; D005618:Fresh Water / Q000737:chemistry*; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000032:analysis; D015203:Reproducibility of Results; D014337:Trout / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D015262:Xenobiotics / Q000378:metabolism* / Q000493:pharmacokinetics
D014874:Water Pollutants, Chemical; D015262:Xenobiotics; D011078:Polychlorinated Biphenyls; D006899:Mixed Function Oxygenases