Intracellular recording of spontaneous activity of canine intracardiac ganglion cells.
Intracellular recordings were made from 302 canine intracardiac ganglion cells with intact synaptic connections. Fifty-two % of these cells exhibited spontaneous membrane potential changes consisting primarily of miniature excitatory postsynaptic potential (EPSP)-like depolarizations upon which an action potential or burst of action potentials was sometimes evoked. Most of the spontaneous potential changes are presumed to be synaptically mediated involving nicotinic mechanisms because they were blocked by low Ca2+/high Mg2+ and hexamethonium solutions.
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Department of Physiology, Loyola University Medical Center, Maywood, IL 60153.
Randall
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Wurster
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D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004285:Dogs; D004594:Electrophysiology; D005724:Ganglia / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D005730:Ganglionic Blockers / Q000494:pharmacology; D006329:Heart Conduction System / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007425:Intracellular Membranes / Q000502:physiology; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials; D013779:Tetrodotoxin / Q000494:pharmacology
D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D018738:Hexamethonium; D013779:Tetrodotoxin; D008274:Magnesium; D002118:Calcium