Prevalence of measles antibodies in asymptomatic human immunodeficiency virus-infected adults.
One hundred five asymptomatic human immunodeficiency virus-seropositive adults were screened for measles antibody. Ages ranged from 21 to 59 years (mean, 35.7). CD4+ lymphocyte counts (range, 76-1137/mm3), percentage of CD4+ cells (6-42), CD4:CD8 ratio (0.08-1.3), measles antibody titers by EIA, and undocumented history of prior measles or immunization were obtained. Forty-six patients gave a history of measles but no immunization, 18 of immunization but no measles, 26 of immunization and measles, and 15 of neither measles nor vaccination. Only one patient (less than 1%) lacked levels of antibody considered protective. Neither the presence nor the level of antibody were predictable from patient age, history of measles or immunization, CD4+ lymphocyte count, percentage of CD4+ cells, or CD4:CD8 ratio. Nearly all subjects had antibody to measles, regardless of immunization or measles history. Whether these antibodies are truly protective is unknown.
Department of Medicine, Rush Medical College/Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
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A A
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Harris
C A
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Benson
W L
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Atkinson
P A
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Urbanski
J A
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Stewart
W W
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Williams
R L
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Murphy
J P
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Phair
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Levin
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes; D002641:Chicago / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008457:Measles / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D008458:Measles Vaccine / Q000276:immunology; D008459:Measles virus / Q000276:immunology*; D008875:Middle Aged; D015995:Prevalence; D011795:Surveys and Questionnaires
D000914:Antibodies, Viral; D008458:Measles Vaccine