HLA-DR3 and variations of the T cell receptor beta gene in Graves' disease.
The association of Graves' disease with two allelic forms of the T cell receptor beta-chain gene (Bgl II restriction fragments 9.2/10.0 kb) was analysed in Caucasians suffering from Graves' disease (N = 54), randomly selected controls (N = 68), and HLA-DR3 homozygous typing control subjects (N = 12). While gene frequencies did not vary in the latter two groups, a significant reduction of 9.2 kb homozygosity was observed in patients with Graves' disease (11 vs 32%, chi 2 = 7.68, p less than 0.01, RR = 0.26). The excess of the 9.2/10.0 kb heterozygosity in patients, which is restricted to the DR3-positive individuals, did not reach significance. The increase in heterozygosity of genomic T cell receptor beta-chain polymorphisms may be attributed to the role the beta-chain plays in autoantigen recognition in Graves' disease.
Medizinische Klinik und Poliklinik, Berufsgenossenschaftliche Krankenanstalten Bergmannsheil, Universitätsklinik, Bochum, Germany.
E
E
Schifferdecker
B
B
Manfras
P
P
Kühnl
G
G
Holzberger
B O
BO
Boehm
D001426:Bacterial Proteins; D015252:Deoxyribonucleases, Type II Site-Specific; D006111:Graves Disease / Q000235:genetics / Q000276:immunology*; D015803:HLA-DR3 Antigen / Q000032:analysis*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
D001426:Bacterial Proteins; D015803:HLA-DR3 Antigen; D011948:Receptors, Antigen, T-Cell; C024404:BglII endonuclease; D015252:Deoxyribonucleases, Type II Site-Specific