Inhibition of different dosages of oxatomide or placebo on skin prick test and nasal allergen provocation.
In this two-stage, double-blind study, we evaluated the effects of different dosages of oxatomide (1 and 2 mg/kg/day) on nasal provocation and skin reaction wheal induced by grass-pollen challenge. Children with a positive history of allergic rhinoconjunctivitis and positive responses to skin prick test and nasal provocation test to grass pollen were studied out of season. The results obtained with 1 mg/kg/day of oxatomide demonstrated no significant difference in wheal areas and nasal secretion induced by allergen challenge between treated and untreated patients. The administration of 2 mg/kg/day demonstrated a significant suppression in wheal reaction and nasal secretion induced by specific challenge.
Piacentini
G L
GL
Department of Pediatrics, University of Verona, Italy.
Peroni
D G
DG
Sette
L
L
Bonizzato
C
C
Benedetti
M
M
Boner
A L
AL
D000293:Adolescent; D002648:Child; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism; D010879:Piperazines / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D011058:Pollen / Q000276:immunology; D012220:Rhinitis / Q000517:prevention & control; D012882:Skin Tests
D006634:Histamine H1 Antagonists; D010879:Piperazines; C015408:oxatomide