[Do antihypertensive agents change the incidence of cardiovascular complications of hypertension?].
The main aim of the treatment of hypertension is to reduce the incidence and severity of its complications. Despite some bias affecting the major clinical trials of diuretics and/or beta blockers, the results of the meta-analysis taking them into account demonstrate the effectiveness of the prevention of cerebrovascular complications and the less effective prevention of coronary complications. Progress can be hoped for as a result of new therapeutic categories (converting enzyme inhibitors, calcium channel inhibitors ...) and to a greater extent from new treatment strategies, involving better identification of "genuinely high risk" subjects.
Service de Cardiologie, Hôpital Bichat, Paris.
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Himbert
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Paillole
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Dahan
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Laperche
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Gourgon
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000517:prevention & control; D002986:Clinical Trials as Topic / Q000379:methods; D003327:Coronary Disease / Q000453:epidemiology* / Q000517:prevention & control; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D015994:Incidence; D008297:Male; D015201:Meta-Analysis as Topic; D012307:Risk Factors
D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D004232:Diuretics
Les traitements anti-hypertenseurs modifient-ils l'incidence des complications cardiovasculaires de l'hypertension artérielle?