Duodenal SP-like immunoreactivity is decreased in experimentally-induced duodenal ulcers.
Substance P-like immunoreactivity (SP-li) is decreased in duodenal samples of animals treated with a single dose of an ulcerogen such as dulcerozine, mepirizole or cysteamine. Unlike dulcerozine- or mepirizole-induced ulcers the degree of cysteamine-induced duodenal lesions is inversely correlated with the levels of duodenal SP-li. A significant decrease in duodenal SP-li was observed at 24 h, but not at 6 h after a single oral dose of cysteamine. These findings show that endogenous SP may play an important local role in duodenal ulcerogenesis.
Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.
S
S
Evangelista
D
D
Renzi
P
P
Mantellini
C
C
Surrenti
A
A
Meli
D000818:Animals; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000378:metabolism*; D004840:Epirizole; D005260:Female; D007150:Immunohistochemistry; D011720:Pyrazoles; D011743:Pyrimidines; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000378:metabolism*
D011720:Pyrazoles; D011743:Pyrimidines; C043452:dulcerozine; D013373:Substance P; D004840:Epirizole; D003543:Cysteamine