Effects of proxigermanium on interferon production and 2',5'-oligoadenylate synthetase activity in the lung of influenza virus-infected mice and in virus-infected human peripheral blood mononuclear cell cultures.
Proxigermanium (SK-818) is a synthesized organic germanium compound having various biological activities. The effects of proxigermanium on interferon (IFN) production in mice infected with influenza virus and virus-infected human peripheral blood mononuclear cells (hPBMC) were investigated. Proxigermanium alone did not induce IFN production in normal mice or in hPBMC without viral infection. On the other hand, proxigermanium enhanced alpha/beta IFN production in viral-infected mice and hPBMC. Since proxigermanium is known to have antiviral activity in vivo but not in vitro, it is likely that the IFN production augumenting activity of proxigermanium is involved in its antiviral activities.
Ishiwata
Y
Y
Mie Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd., Japan.
Yokochi
S
S
Suzuki
E
E
Michishita
H
H
Tashita
A
A
Asano
K
K
Mitani
T
T
Kurono
M
M
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D005857:Germanium / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D009980:Influenza A virus; D007251:Influenza, Human / Q000378:metabolism*; D007372:Interferons / Q000096:biosynthesis*; D008168:Lung / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D011422:Propionates
D000276:Adjuvants, Immunologic; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D011422:Propionates; D005857:Germanium; C066750:propagermanium; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase