Synthetic detergents induced-biochemical and histological changes in skin of guinea pigs.
The linear alkylbenzene sulphonate (LAS) based synthetic detergents-induced decrease in lipid peroxydation and increase in histamine content in exposed skin of guinea pigs in a dose-dependent manner. Histopathological alterations of exposed skin included moderate degree of hyperkeratinization at lower concentration but necrosis, scarring, sloughing as well as discontinuity of epidermis at higher concentrations. The results shows that the contact of skin with detergents causes dermal toxicity.
Industrial Toxicology Research Centre (ITRC), Lucknow, India.
C
C
Agarwal
A K
AK
Mathur
B N
BN
Gupta
A
A
Singh
R
R
Shanker
D000476:Alkanesulfonates / Q000633:toxicity*; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D003902:Detergents / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D013501:Surface-Active Agents / Q000633:toxicity*
D000476:Alkanesulfonates; D003902:Detergents; D013501:Surface-Active Agents