Coupling daunorubicin to monoclonal antialphafoetoprotein with a new activated derivative.
We report the synthesis of daunorubicin antialphafoetoprotein conjugates, using a new coupling method. At equimolar concentrations on AFP producing cells in vitro, these conjugates were found three times as cytotoxic as the free drug.
Department of Biochemistry, Faculty of Medicine, Université Laval, Sainte-Foy, Québec, Canada.
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D000818:Animals; D000911:Antibodies, Monoclonal; D002470:Cell Survival / Q000187:drug effects; D003630:Daunorubicin / Q000627:therapeutic use*; D004347:Drug Interactions; D005976:Glutaral / Q000494:pharmacology; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D014407:Tumor Cells, Cultured; D000509:alpha-Fetoproteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D000509:alpha-Fetoproteins; D005976:Glutaral; D003630:Daunorubicin