The relationship of prostaglandins to cAMP, IgG, IgM and alpha-2-macroglobulin in gingival crevicular fluid in chronic adult periodontitis.
Gingival crevicular fluid, collected from 8 patients with chronic adult periodontitis before and 21 days after root planing and scaling, was analysed for prostaglandin E2, 6KPGF1 alpha, cAMP, IgG, IgM and alpha-2-macroglobulin, and their inter-relationship evaluated. There was a significant decrease in the levels of prostaglandin E2, IgG, IgM and alpha-2-macroglobulin after treatment, whereas the levels of 6KPGF1 alpha and cAMP remained essentially unchanged. The level of prostaglandin E2 decreased by 35%, IgG by 32%, IgM by 90%, and alpha-2-macroglobulin by 79%. There was a significant degree of correlation between prostaglandin E2 and 6KPGF1 alpha and cAMP before treatment but not after, but no correlation between prostaglandin E2 and IgG, IgM and alpha-2-macroglobulin either before or after. This correlation pattern indicates the involvement of E2, prostaglandin 6KPGF1 alpha and cAMP in inflammation in the periodontium. The changes in IgG, IgM and alpha-2-macroglobulin reflect yet another mechanism of host response which appears to be independent of prostaglandins.
Research Center, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark 07103.
S
S
Sengupta
J
J
Fine
C Y
CY
Wu-Wang
J
J
Gordon
V L
VL
Murty
A
A
Slomiany
B L
BL
Slomiany
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis*; D000328:Adult; D002908:Chronic Disease; D000242:Cyclic AMP / Q000032:analysis*; D012534:Dental Scaling; D015232:Dinoprostone / Q000032:analysis*; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000201:enzymology / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D010518:Periodontitis / Q000201:enzymology / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D014092:Tooth Root / Q000601:surgery; D000511:alpha-Macroglobulins / Q000032:analysis*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D000511:alpha-Macroglobulins; D015121:6-Ketoprostaglandin F1 alpha; D000242:Cyclic AMP; D015232:Dinoprostone