Thalamic projections to sensorimotor cortex in the newborn macaque.
In the present experiments thalamocortical projections to different functional areas of the newborn (or prematurely delivered) macaque's sensorimotor cortex were labeled using retrogradely transported fluorescent dyes. Several dyes were used in each animal to (1) enable the direct comparison of the soma distributions of different thalamocortical projections within thalamic space, and (2) identify by double labeling neurons shared between these distributions. The projection patterns in the newborn macaque were compared with those of the mature animal reported by Darian-Smith et al. (J. Comp. Neurol. 1990;298:000-000). The main observations were (1) all thalamocortical projections to the sensorimotor cortex of the mature macaque are well established by embryonic days 146-150, as was shown by labeling these pathways in infants delivered by cesarean section, (2) a significant number of thalamocortical neurons in the newborn were double-labeled following dye injections into different pre- or postcentral areas, and where the margins of the dye uptake zones were separated by 3-8 mm, and (3) extensive projections from the anterior pulvinar nucleus to the motor and premotor cortex, and to the supplementary motor cortex were labeled in the newborn macaque. Both the exuberant terminal arborizations, and the precentral pulvinar projections were diminished by the 6th postnatal month, and absent in the mature macaque. The role of epigenetic determinants of these postnatal events is briefly considered.
Darian-Smith
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Department of Anatomy, University of Melbourne, Parkville, Victoria, Australia.
Darian-Smith
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Cheema
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D000344:Afferent Pathways / Q000033:anatomy & histology / Q000254:growth & development; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001370:Axonal Transport; D001921:Brain / Q000254:growth & development*; D008252:Macaca fascicularis / Q000033:anatomy & histology*; D008254:Macaca nemestrina / Q000033:anatomy & histology*; D009044:Motor Cortex / Q000033:anatomy & histology* / Q000254:growth & development; D009474:Neurons / Q000166:cytology; D013788:Thalamus / Q000033:anatomy & histology* / Q000254:growth & development