[Effects of prolonged administration of dapiprazole in rats].
In this paper we have studied the rat under chronic treatment with dapiprazole ip. (a drug with alpha-adrenergic blocking properties). For a 4 week period we have recorded, once a week, weight, rectal temperature, tail-flick, general activity and explorative behaviour on rotarod and one-arm radial maze. Surface (SEEG) and deep (DEEG) EEGrams were also recorded at the end of the experiments (4th week). SEEG and DEEG underwent the Fourier analysis (Fast Fourier Transform--see text). The findings were: 1) No change was observed in weight, rectal temperature and tail-flick time, glycemia and haematocrit. 2) Motor coordination on rotaroad dropped in 1st and 3rd week of treatment. 3) The treated rats, when in a one arm radial maze, showed signs of sedation (no grooming) from 2nd week of treatment. 4) SEEG and DEEG recordings showed a slowing activity; Fourier analysis confirmed these results. The slowing of activity (4) well agrees with the signs of sedation and behaviour (2, 3). It seems thus confirmed that alpha-adrenergic blockade is a feature of the drug together with the psychotropic effects previously described.
Istituto di Farmacologia Medica, Università degli Studi di Roma La Sapienza.
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Sopranzi
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de Feo
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Pace
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Del Vecchio
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Bonaventura
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D004569:Electroencephalography; D005583:Fourier Analysis; D008297:Male; D010879:Piperazines; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014230:Triazoles / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D014150:Antipsychotic Agents; D010879:Piperazines; D014230:Triazoles; C035289:dapiprazole
Effetti di una prolungata somministrazione di dapiprazolo nel ratto.