[Analysis of the effectiveness of pilocarpine in the management of xerostomia].
The authors have studied the "sympathetic like" side effect of pilocarpine after single injection (1 mg/100 g b.w., i.p.) of the drug. They developed a system for the continuous automatic recording the amylase activity of the saliva secreted by the parotid glands of rats, "in situ". Pilocarpine stimulus was characterized by a peak in amylase activity--regularly observed in the first 40-60 min--which was additive to the cholinergic amylase secretory response. After this the amylase secretion was continued with lower activity. The role of a beta-adrenergic component in the pilocarpine stimulus appears to be supported by the finding that propranolol (2.5 mg/100 g b.w., i.p.) pretreatment applied 30 min prior to the pilocarpine stimulus prevented the appearance of the characteristic amylase peak. These data support that the beta-adrenergic side effect triggering the periodical synthesis of export proteins during the course of pilocarpine treatment accounts for the selative efficiency of pilocarpine in the therapy of xerostomia.
Semmelweis Orvostudományi Egyetem Orálbiológiai Tanszék, Budapest.
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Zelles
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Blazsek
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Kelemen
D000681:Amylases / Q000378:metabolism; D006801:Humans; D010862:Pilocarpine / Q000494:pharmacology / Q000627:therapeutic use*; D012463:Saliva / Q000201:enzymology / Q000378:metabolism; D014987:Xerostomia / Q000188:drug therapy* / Q000201:enzymology
D010862:Pilocarpine; D000681:Amylases
A pilocarpin hatékonyságágak elemzése a xerostomia kezelésében.