Carbovir: the (-) enantiomer is a potent and selective antiviral agent against human immunodeficiency virus in vitro.
In this paper we describe the in vitro antiviral activity of the (-) enantiomer of carbocyclic 2',3'-deoxydidehydroguanosine, (-) carbovir, a nucleoside analogue that has selective and potent anti-HIV activity in a series of lymphocyte culture systems. The cellular cytotoxicity of this compound has also been evaluated in a number of systems and compared to the saturated dideoxynucleoside analogues AZT and ddC.
Department of Virology, Glaxo Group Research Limited, Greenford, U.K.
J A
JA
Coates
H J
HJ
Inggall
B A
BA
Pearson
C R
CR
Penn
R
R
Storer
C
C
Williamson
J M
JM
Cameron
D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015224:Dideoxynucleosides / Q000494:pharmacology* / Q000633:toxicity; D015726:Giant Cells / Q000187:drug effects; D006678:HIV / Q000187:drug effects*; D006801:Humans; D014758:Viral Core Proteins / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects; D016047:Zalcitabine / Q000494:pharmacology; D015215:Zidovudine / Q000494:pharmacology
D015224:Dideoxynucleosides; D014758:Viral Core Proteins; C057503:carbovir; D015215:Zidovudine; D016047:Zalcitabine