Inhibition of angiogenesis by vitamin D3 analogues.
The effects of vitamin D3 and two analogues on embryonic angiogenesis were studied in 4.5-day-old chick embryo chorioallantoic membranes. The active metabolite of vitamin D3, 1 alpha,25-dihydroxyvitamin D3, and a synthetic vitamin D3 analogue, 22-oxa-1 alpha,25-dihydroxyvitamin D3, inhibited angiogenesis in a dose-dependent manner, the inhibition occurring in the picomolar range. In contrast, vitamin D3 was not effective. The results suggest that these two vitamin D3 analogues might be promising anti-angiogenic agents for controlling the angiogenesis which occurs in several pathological conditions, including tumor development.
Oikawa
T
T
Division of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Japan.
Hirotani
K
K
Ogasawara
H
H
Katayama
T
T
Nakamura
O
O
Iwaguchi
T
T
Hiragun
A
A
D000818:Animals; D002117:Calcitriol / Q000031:analogs & derivatives / Q000494:pharmacology; D002642:Chick Embryo; D002762:Cholecalciferol / Q000494:pharmacology*; D009389:Neovascularization, Pathologic
D002762:Cholecalciferol; D002117:Calcitriol; C051883:maxacalcitol