[The effect of hadacidin, ultraviolet irradiation of blood (UVB) and thiamine on the prenatal development of Uje:WIST rats: correlation with the hepatic activity of gamma-glutamyltranspeptidase (GGT)].
The influence of hadacidin, a model substance for induction of cheilognathouranoschisis in rat fetuses (2,550 mg/kg b.m. at gestation day 12), ultraviolet irradiation (UVB) of blood (1 week before gestation) and thiamine (25 mg/kg b.m. from gestation days 12 to 15) on the prenatal development of rats at the 20th day of gestation was investigated. Using the body mass and the hepatic GGT-activity as parameters. Hadacidin caused a distinct retardation of the fetal somatic development. Partially, the embryotoxic effect was compensated by UVB or thiamine. The combination of both procedures was more effective. There is a good correlation between the maturation grade of fetuses at day 20 of gestation and the hepatic GGT activity.
Klinik und Poliklinik für Kiefer-Gesichtschirurgie und Plastische Chirurgie, Friedrich-Schiller-Universität Jena.
T
T
Wagner
M
M
Kretzschmar
W
W
Klinger
W
W
Zenk
D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects* / Q000528:radiation effects; D005260:Female; D005998:Glycine / Q000009:adverse effects / Q000031:analogs & derivatives*; D008099:Liver / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D013831:Thiamine / Q000009:adverse effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D005723:gamma-Glutamyltransferase / Q000032:analysis*
C001321:hadacidin; D005723:gamma-Glutamyltransferase; D005998:Glycine; D013831:Thiamine
Der Einfluss von Hadacidin, Ultraviolettbestrahlung des Blutes (UVB) und Thiamin auf die pränatale Entwicklung bei Uje: WIST-Ratten: Korrelation zur hepatischen Aktivität der Gamma-Glutamyl-transpeptidase (GGT).