Melanotic schwannoma. Clinicopathologic, immunohistochemical, and ultrastructural features of a rare primary bone tumor.
The authors report a 35-year-old woman who presented with a lytic and blastic tumor of the ilium with soft tissue extension. The resected tumor showed light microscopic and ultrastructural features characteristic of a melanotic schwannoma. An unusual histologic finding was the presence of laminated concretions resembling psammoma bodies. Immunohistochemical stains for S-100, HMB-45, and vimentin were strongly positive. The patient is free of disease 18 months after complete surgical excision.
Department of Radiology, University of Alabama, Birmingham.
J L
JL
Myers
W
W
Bernreuter
W
W
Dunham
D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007085:Ilium; D007150:Immunohistochemistry; D008545:Melanoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D008854:Microscopy, Electron; D009442:Neurilemmoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D011379:Prognosis; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed