Differential bleomycin susceptibility in cultured lymphocytes of fragile X patients and normal individuals.
The frequency of bleomycin-induced chromatid breaks was studied in cultured lymphocytes from ten fragile X patients and ten healthy controls. The results showed that the frequency of chromatid breaks was significantly higher among fragile X patients than among normal individuals. We suggest that the fragile X patients may be more susceptible to mutagens and carcinogens and, therefore, more prepotent to neoplastic induction.
Li
S Y
SY
Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Republic of China.
Lin
J K
JK
D001761:Bleomycin / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D004260:DNA Repair / Q000235:genetics; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D012854:Sister Chromatid Exchange
D001761:Bleomycin