Do calcium channel blockers have any influence on the immunological status of renal graft recipients on ciclosporin therapy?
We have assessed the peripheral distribution of T cells, using the monoclonal antibodies OKT3, OKT4, OKT8 and LEU7 and the proliferative response to phytohaemagglutinin (PHA), in 10 renal transplant recipients. In each patient, the immunological pattern was evaluated twice, both before and after 1 month of calcium antagonist (calcium channel blockers, CaA) treatment. During treatment with CaA, we have observed both a significant decrease in the mitogenic response to PHA and a significant increase in OKT8 cells. Our data support the hypothesis that CaAs per se may have an immunomodulatory effect on T cell distribution independently of changes in ciclosporin (CS) blood levels. These results could also provide a cellular basis for synergism between CS and CaA.
Mandreoli
M
M
Department of Nephrology, S. Maria delle Croci Hospital, Ravenna, Italy.
Esposti
E D
ED
Cocchi
R
R
Fabbri
A
A
Guerrini
L
L
Fusaroli
M
M
D000276:Adjuvants, Immunologic; D000328:Adult; D003524:Cyclosporins / Q000097:blood / Q000627:therapeutic use*; D004110:Diltiazem / Q000494:pharmacology*; D000939:Epitopes; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000494:pharmacology*; D010659:Phenylhydrazines / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology
D000276:Adjuvants, Immunologic; D003524:Cyclosporins; D000939:Epitopes; D010659:Phenylhydrazines; C006384:N(1)-acetylphenylhydrazine; D009529:Nicardipine; D004110:Diltiazem