A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.
Genomic clones containing the exons coding for the bait domain of human pregnancy zone protein and alpha 2 macroglobulin were isolated and fragments containing the bait exons were sequenced. It is shown that the bait domains of both alpha 2 macroglobulin and pregnancy zone protein are encoded by two exons, with conserved exon/intron boundaries. A genetic polymorphism showing either a Met or a Val residue as the sixth amino acid of the pregnancy zone protein bait domain was detected with the rare Met allele showing a gene frequency of 0.065.
Center for Human Genetics, University of Leuven, Belgium.
P
P
Marynen
K
K
Devriendt
H
H
Van den Berghe
J J
JJ
Cassiman
D000595:Amino Acid Sequence; D001483:Base Sequence; D005075:Biological Evolution; D004247:DNA / Q000032:analysis; D005091:Exons; D006801:Humans; D008969:Molecular Sequence Data; D010375:Pedigree; D010920:Placenta / Q000032:analysis; D011110:Polymorphism, Genetic; D011257:Pregnancy Proteins / Q000235:genetics*; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D000511:alpha-Macroglobulins / Q000235:genetics*
D011257:Pregnancy Proteins; D000511:alpha-Macroglobulins; D004247:DNA