[Preparation of rotundine-chitosan gelled granules and their drug-release tests].
The paper described a delivery system prepared from granulation of a chitosan solution containing rotundine in a coagulating bath and examined the effects of the ratios of rotundine: chitosan, crosslinking agents and molecular weight of chitosan on the analgesic release rate. It was shown that the rotundine (56.7%)-chitosan (Mw:5.70 x 10(5) degree of deacetylation: 72.4%) gelled granules in an artificial gastroenteric juice (pH 1.0 and 7.2) have T50 of 40 and 180 min respectively, and the total release time sustained over 540 min.
Liu
X J
XJ
Chengdu Institute of Organic Chemistry, Academia Sinica.
Xie
S S
SS
Zhang
Y X
YX
Zhang
J L
JL
Zhang
D
D
Wang
Y L
YL
Ni
D
D
Li
D
D
Lu
M
M
Ye
Q T
QT
D000470:Alkaloids / Q000008:administration & dosage*; D000700:Analgesics / Q000008:administration & dosage*; D014150:Antipsychotic Agents / Q000008:administration & dosage*; D001600:Berberine Alkaloids / Q000008:administration & dosage*; D002686:Chitin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D048271:Chitosan; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems
D000470:Alkaloids; D000700:Analgesics; D014150:Antipsychotic Agents; D001600:Berberine Alkaloids; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002686:Chitin; C014215:tetrahydropalmatine; D048271:Chitosan