[4-Tesla 1H MR spectroscopy in patients with temporal lobe epilepsy].
7 patients with drug-resistant temporal lobe epilepsy (TLE) and localized EEG-focus were investigated with a 4 Tesla whole body MR-scanner. Proton (1H) magnetic resonance (MR) spectra were analyzed quantitatively and compared to the healthy side. MRS allowed the differentiation of the following metabolites in 5 patients: N-acetyl-aspartate (NAA), creatine and phosphocreatine, phosphorylcholine and glycerophosphorylcholine, beta- and gamma-glutamate (GLU). To compare the results with those of an already evaluated normal population, these metabolites were measured also in parietal region. The standard deviation was 42-46% in the patients. Unfortunately, in the temporal region, the field homogeneity was worse than parietal and thus the spectral analysis less distinct especially for GLU with a standard deviation of 45% for NAA and 66% for GLU on the healthy side. Thus, no significant findings were seen on focus side. There was only a tendency to an elevation of glutamate and a reduction of N-acetyl-aspartate.
Schüler
P
P
Neurologische Klinik, Universität Erlangen-Nürnberg.
Stefan
H
H
Schuierer
G
G
Hentschel
D
D
Ladebeck
R
R
Wittig
R
R
Huk
W
W
Neundörfer
B
B
D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D004828:Epilepsies, Partial / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D004830:Epilepsy, Tonic-Clonic / Q000503:physiopathology; D005260:Female; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006801:Humans; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010725:Phosphocreatine / Q000378:metabolism; D010767:Phosphorylcholine / Q000378:metabolism; D012016:Reference Values; D013702:Temporal Lobe / Q000503:physiopathology
D005971:Glutamates; D007773:Lactates; D010725:Phosphocreatine; D010767:Phosphorylcholine; D001224:Aspartic Acid; D019344:Lactic Acid; D018698:Glutamic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline
4-Tesla 1H-MR-Spektroskopie bei Patienten mit Temporallappenepilepsie.