The effect of schistosomiasis on the covalent binding of 2-acetylaminofluorene to mouse liver macromolecules in vivo and in vitro.
The covalent binding of [14C]acetylaminofluorene (AAF) to macromolecules in vivo and in vitro was measured in Schistosoma mansoni-infected and in non-infected mice. Liver microsomes from infected mice demonstrated a 42% decreased capacity to mediate covalent binding of AAF to DNA. In addition, the extent of binding of AAF to liver macromolecules in vivo was generally less in infected than non-infected mice.
Siwela
A H
AH
Department of Biochemistry, University of Zimbabwe.
Nyathi
C B
CB
Chetsanga
C J
CJ
Hasler
J A
JA
D015073:2-Acetylaminofluorene / Q000378:metabolism*; D000818:Animals; D004247:DNA / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D011485:Protein Binding; D012313:RNA / Q000378:metabolism; D012552:Schistosomiasis / Q000378:metabolism*
D012313:RNA; D004247:DNA; D015073:2-Acetylaminofluorene