Blood gas and acid-base status of conscious pigs subjected to fixed-volume hemorrhage and resuscitated with hypertonic saline dextran.
Conscious, chronically instrumented pigs were subjected to a progressive, fixed-volume hemorrhage (37.5 ml/kg over 1 h) and subsequent resuscitation with 7.5% hemorrhage (37.5 ml/kg over 1 h) and subsequent resuscitation with 7.5% NaCl/6% Dextran 70 (4 ml/kg). Hemorrhage led to increases in arterial PO2, HbO2, plasma lactate, base deficit, and mixed venous PCO2. It led to decreases in arterial PCO2, plasma bicarbonate, and buffer base, as well as mixed venous PO2, HbO2, and pH. These effects were attributable to reduced O2 delivery, lactacidemia, hyperventilation, and hemodilution. Resuscitation with hypertonic saline/dextran produced a transient increase in arterial PCO2 and base deficit and a transient decrease in pH, effects that were attributable to a transfer of venous blood attributes to the arterial circulation. Resuscitation also produced an immediate decrease in arterial buffer base, an effect attributable to hemodilution. Subsequently, over 4 h, most cardiopulmonary and metabolic variables gradually reverted toward control levels, thereby ameliorating the deleterious blood gas and acid-base disturbances produced by severe hemorrhage.
Division of Military Trauma Research, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129-6800.
J P
JP
Hannon
C E
CE
Wade
C A
CA
Bossone
M M
MM
Hunt
R I
RI
Coppes
J A
JA
Loveday
D000137:Acid-Base Imbalance / Q000209:etiology* / Q000628:therapy; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001769:Blood; D002245:Carbon Dioxide / Q000097:blood; D003911:Dextrans / Q000627:therapeutic use*; D006470:Hemorrhage / Q000097:blood / Q000150:complications* / Q000628:therapy; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D010100:Oxygen / Q000097:blood; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D013552:Swine
D001639:Bicarbonates; D003911:Dextrans; D007773:Lactates; D012462:Saline Solution, Hypertonic; D002245:Carbon Dioxide; D019344:Lactic Acid; D010100:Oxygen