The origin of a double insertion of homogeneously staining regions in the house mouse (Mus musculus musculus).
A high resolution analysis of the G-band patterns of normal and aberrant chromosomes 1, bearing two linked insertions of homogeneously staining regions (HSRs) in the house mouse (Mus musculus musculus) reveals the inverted pattern of the euchromatic region between the HSRs. On the basis of this analysis a hypothesis on the origin of the aberrant chromosome is put forward: the double insertion is a result of an inversion of the chromosome 1 of Mus musculus domesticus bearing a single insertion of HSR. The proximal breakpoint is localized inside the HSR, and the distal one between subbands E3 and E4.
Institute of Cytology and Genetics, Siberian Department of the Academy of Sciences of the U.S.S.R., Novosibirsk.
S I
SI
Agulnik
P M
PM
Borodin
I P
IP
Gorlov
Ladygina TYu
S D
SD
Pak
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D007446:Chromosome Inversion; D005784:Gene Amplification / Q000235:genetics; D051379:Mice / Q000235:genetics*; D016254:Mutagenesis, Insertional / Q000235:genetics*; D013194:Staining and Labeling