[Efficacy of various treatment methods to extend the ischemia tolerance time of the liver. Experimental studies in dogs].
In a pilot-study (n = 66) and subsequent controlled experiment (n = 32) the ischemic tolerance of dog liver is examined by means of various clinical and laboratory parameters. During normothermia and without venous decompression the time of ischemic tolerance amounts to 60 minutes. Hypothermia and systemic administration of Aprotinin (Trasylol) and Methylprednisolone (Urbason) do not prolong the tolerance time of ischemia. This time is significantly extended by pre-operative administration of a thiourea-derivate (Propycil). Basing on this decisive improvement of the ischemic tolerance of dog liver, new advances in increasing the ischemic tolerance of human liver are offered.
Chirurgische Klinik des St.-Katharinen-Krankenhauses Frankfurt/M.
W
W
Fabian
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D004285:Dogs; D007511:Ischemia / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000601:surgery; D008102:Liver Circulation / Q000187:drug effects; D008775:Methylprednisolone / Q000494:pharmacology; D010865:Pilot Projects; D011441:Propylthiouracil / Q000494:pharmacology; D013997:Time Factors
D011441:Propylthiouracil; D007611:Aprotinin; D008775:Methylprednisolone
Die Effektivität verschiedener Behandlungsmethoden zur Verlängerung der Ischämietoleranz der Leber. Experimentelle Untersuchungen beim Hund.