Estrogen receptors in colorectal adenocarcinomas and in other large bowel diseases.
Seventy-two patients with tumor and ten with non-neoplastic colon disease were studied for the presence of estrogen receptors (ER) by three different methods. Only seven specimens (six primary adenocarcinomas and one recurrent cancer) had an ER concentration above 3 fm/mg of cytosolic protein, with no sex, age and tumor stage correlation. Our results suggest that the large bowel does not contain a cytosolic receptor for estradiol.
Emergency Surgery Institute of Turin University, Italy.
C
C
Sciascia
G
G
Olivero
A
A
Comandone
T
T
Festa
M G
MG
Fiori
F
F
Enrichens
D000230:Adenocarcinoma / Q000378:metabolism*; D000368:Aged; D003106:Colon / Q000378:metabolism; D003108:Colonic Diseases / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D003911:Dextrans; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D011479:Protamines; D011960:Receptors, Estrogen / Q000378:metabolism*
D003911:Dextrans; D011479:Protamines; D011960:Receptors, Estrogen