[The effect of long-term administration of metipranolol on passive diastolic properties of the hypertrophic ventricle].
In the course of adaptation of the rabbit heart to volume load passive diastolic properties of the hypertrophic ventricle and myocardium were changing significantly. On day 30 following perforation of the aortic valve stiffness of the ventricle was reduced, yet normalized ventricular stiffness and myocardial stiffness were increased. These changes were prevented by beta adrenergic blockade during development of adaptation of the heart to volume load. Although ventricular stiffness was reduced, normalized ventricular stiffness and myocardial stiffness remained at the level of control values. The demonstrated effect of beta adrenergic blockade on passive diastolic properties of the ventricle and myocardium may be of value in preventing heart failure due to chronic hemodynamic load. (Tab.3,Ref.15.).
Katedry patologickej fyziológie LFUK v Bratislave.
M
M
Turcáni
A
A
Fízel'
D
D
Maasová
A
A
Fízel'ová
F
F
Simko
E
E
Sapáková
D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects*; D008297:Male; D014290:Metipranolol / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D016277:Ventricular Function, Left / Q000187:drug effects*
D014290:Metipranolol
Vplyv dlhodobého podávania metipranololu na pasívne diastolické vlastnosti hypertrofovanej komory.