[Cured of testicular cancer; does life just go on?].
From 1976 through 1979 we have treated 91 patients with disseminated non-seminomatous testicular cancer with induction chemotherapy comprising cisplatin, vinblastine and bleomycin. After 4 induction cycles complete responders went on to receive maintenance therapy with cisplatin and vinblastine for a median of one year. Fifty-seven patients (63%) are at present alive and free of disease. Seven to ten years after the start of treatment we have investigated their physical, mental and social situation by means of a questionnaire and by collection of data from the charts. It appeared that 90% of the respondents were fully employed. However, over half of the men reported symptoms of polyneuropathy and 40% experienced sexual function disturbances. Part of these problems were due to the maintenance chemotherapy, which has been abandoned in our country since 1982.
Koopman
A
A
Academisch Ziekenhuis Vrije Universiteit, afd. Interne Geneeskunde, Amsterdam.
Vendrik
C P
CP
Sleyfer
D T
DT
van Oosterom
A T
AT
ten Bokkel Huinink
W W
WW
Stoter
G
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002423:Cause of Death; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D007172:Erectile Dysfunction / Q000209:etiology; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D011788:Quality of Life; D013736:Testicular Neoplasms / Q000401:mortality / Q000534:rehabilitation / Q000628:therapy*; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin
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