Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo.
Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.
Institute of Pathology, University Hospital, Zurich, Switzerland.
H
H
Pircher
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Moskophidis
U
U
Rohrer
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K
Bürki
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H
Hengartner
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RM
Zinkernagel
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000235:genetics / Q000276:immunology; D001483:Base Sequence; D003001:Cloning, Molecular; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D014644:Genetic Variation; D006023:Glycoproteins / Q000235:genetics; D008216:Lymphocytic Choriomeningitis / Q000276:immunology / Q000382:microbiology; D008217:Lymphocytic choriomeningitis virus / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D013154:Spleen / Q000382:microbiology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000956:Antigens, Viral; D000939:Epitopes; D006023:Glycoproteins; D011948:Receptors, Antigen, T-Cell