[Preliminary evaluation of prognostic factors in selecting the methods of treatment of patients with stage I testicular seminoma].
The management of 50 patients with seminomas in 1st stage of the clinical advancement after orchidectomy in the Oncology Center in Warsaw in the period since January 1984 until June 1989 depended on the presence of high risk factors (the infiltration of the tunica albuginea of the testis of the epididymis and/or testicular cord, and the presence of cellular cancer embolisms in the blood or lymphatic vessels). In 11 (out of 50) patients in which such factors have been present three courses of chemotherapy according to PVB programme have been applied (DDP-80 mg/m. sq. i.v. (on the 1st day; VLB-10 mg, i.v., day 1-2, BLM-30 mg i.v., 2nd, 9th and 16th day, 21 days rhythm). The remaining group of 39 patients without microscopic factors have been observed without treatment ("wait and watch policy"). During the follow up of 17 patients receiving PVB (mean 17 months) in no one case the progression of the disease have been noticed. In 2 (out of 39) patients observed without treatment in 6th and 8th month correspondingly, the progression of the disease has been found and chemotherapy according to PVB programme applied with subsequent irradiation of the regional lymphatic system, with complete remission as result. Both patients are alive for 14 and 16 months correspondingly without active disease.
Przychodni Centrum Onkologii, Instytutu im. Marii Skłodowskiej-Curie w Warszawie.
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Madej
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Pawiński
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D004407:Dysgerminoma / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009919:Orchiectomy / Q000379:methods*; D011379:Prognosis; D013736:Testicular Neoplasms / Q000473:pathology / Q000628:therapy*; D014747:Vinblastine / Q000008:administration & dosage
D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin
Wstepna ocena czynników rokowniczych w wyborze metody leczenia chorych na nasieniaka jadra w I stopniu zaawansowania.