Direct action of human granulocyte colony-stimulating factor on mature human neutrophils: flow-cytometric analysis.
The direct effects of human granulocyte colony-stimulating factor (G-CSF) on mature neutrophils in vitro were studied using flow cytometry. G-CSF increased the neutrophil forward scatter without recruitment of side scatter, as assessed by flow cytometry. This indicates that G-CSF acts on neutrophils directly and induces the activation of mature neutrophils without degranulation of primary granules.
Kondo
S
S
Cancer Center, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Okamura
S
S
Ohhara
N
N
Niho
Y
Y
D003115:Colony-Stimulating Factors / Q000494:pharmacology*; D005434:Flow Cytometry / Q000379:methods; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D009504:Neutrophils / Q000187:drug effects*; D011994:Recombinant Proteins / Q000494:pharmacology; D012542:Scattering, Radiation
D003115:Colony-Stimulating Factors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor