Role of histamine in the development of neurogenic inflammation of rat oral mucosa.
The mechanism of development of neurogenic inflammatory reaction induced by the topical application of capsaicin was studied in the oral mucosa of rats with or without histamine antagonist pretreatment. The existence of a cholinergic component of the vasodilation was investigated using a muscarinic receptor antagonist. Results indicated that the neurogenic inflammatory increases in vascular permeability and blood flow are mediated in part by H1-receptors, H2-receptors and cholinergic pathways are apparently not activated in these processes.
Department of Pathophysiology Semmelweis University Medical School, Budapest.
A
A
Györfi
A
A
Fazekas
E
E
Pósch
F
F
Irmes
L
L
Rosivall
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects; D002211:Capsaicin; D002927:Cimetidine / Q000494:pharmacology; D005029:Ethylenediamines / Q000494:pharmacology; D005070:Evans Blue / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology / Q000502:physiology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D009061:Mouth Mucosa / Q000098:blood supply / Q000294:innervation*; D018727:Muscarinic Antagonists; D009443:Neuritis / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011969:Receptors, Histamine H1 / Q000502:physiology; D011976:Receptors, Muscarinic / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects
D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D018727:Muscarinic Antagonists; D011969:Receptors, Histamine H1; D011976:Receptors, Muscarinic; C004664:chloropyramine; D005070:Evans Blue; D001285:Atropine; D002927:Cimetidine; D006632:Histamine; D002211:Capsaicin