5-HIAA in cerebrospinal fluid and deficit schizophrenic characteristics.
Higher CSF 5-HIAA concentrations and lower CSF HVA concentrations have been associated with various measures of slowed motor behaviour and communication in schizophrenic patients. To derive a single, reliable measure of deficit characteristics in schizophrenic patients, we entered four items of the BPRS reflecting negative symptoms, a work history measure derived from the Strauss-Carpenter scale, and three subscale scores of the WAIS-R into a principal-components analysis to derive a single factor score. The CSF 5-HIAA concentrations were within the normal range of values, and correlated directly with this factor score, but CSF HVA concentrations were not associated with the deficit factor score. These findings add support to the hypothesis that brain serotonin function is associated with deficit schizophrenic characteristics.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA.
J G
JG
Csernansky
R J
RJ
King
W O
WO
Faustman
J A
JA
Moses
M E
ME
Poscher
K F
KF
Faull
D000328:Adult; D003071:Cognition; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D013129:Spinal Puncture
D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid