Imaging of metastatic colorectal cancer with tumour-activated killer lymphocytes.
Adoptive immunotherapy may be useful for treating or visualising metastatic cancer. Lymphocytes were taken from 6 patients with metastatic colorectal cancer and cultured with cells from the patients primary tumour to produce tumour-activated killer (TAK) lymphocytes. We re-injected each patient with IIIIn-labelled TAK cells in order to visualise metastases. Images were taken with a gamma-camera for up to 48 h after injection. Metastases were revealed as early as 4 h in the lung and as late as 48 h in the abdomen. Liver images produced "cold" spots corresponding to metastatic lesions. Lymph nodes were not visualised. Re-injection of TAK cells raised against autologous colorectal tumours reveals the sites of metastases.
Department of Surgery, Hammersmith Hospital London, UK.
R I
RI
Swift
H J
HJ
Danpure
S
S
Osman
J
J
Gaer
C
C
Tsikos
A M
AM
Peters
J P
JP
Lavender
S
S
Tebbut
N A
NA
Habib
C B
CB
Wood
D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D000368:Aged; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D016246:Lymphocytes, Tumor-Infiltrating / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
D007205:Indium Radioisotopes