Effects of minimum inhibitory concentrations of three antimicrobials on the growth cell and fimbriation of uropathogenic Escherichia coli.
Uropathogenic E. coli 36692 cells synthesize fimbriae during the first half of the exponential growth curve. The presence of the appendices was detected by electron microscopy and it was correlated with a high haemagglutination activity. Norfloxacin, amoxicillin and gentamicin supply 1/4 of their respective MICs, inhibiting the cell growth. Also all these drugs with the same sub MICs alter the haemagglutination titre and inhibit the fimbriation process of the uropathogenic E. coli. Gentamicin showed the highest inhibition of the haemagglutinating activity and fimbriae synthesis.
Department of Biological Sciences, Universidad de Talca, Chile.
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Padilla
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Vásquez
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Faúndez
D018830:Adhesins, Escherichia coli; D000658:Amoxicillin / Q000494:pharmacology*; D000942:Antigens, Bacterial / Q000032:analysis; D001422:Bacterial Adhesion / Q000187:drug effects; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis; D004926:Escherichia coli / Q000737:chemistry / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity / Q000648:ultrastructure; D010861:Fimbriae, Bacterial / Q000187:drug effects / Q000378:metabolism; D005839:Gentamicins / Q000494:pharmacology*; D006388:Hemagglutinins / Q000032:analysis; D009643:Norfloxacin / Q000494:pharmacology*
D018830:Adhesins, Escherichia coli; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D005839:Gentamicins; D006388:Hemagglutinins; D000658:Amoxicillin; D009643:Norfloxacin