[Differentiation behavior of human vaginal epithelium exemplified by keratin expression].
The biochemical and immunohistochemical detection of keratins proves, that the human epithelium of the vagina is a mosaic of differentiation, because of its simultaneous realisation of opposite differentiation pathways in either nonkeratinizing squamous epithelium, identifiable by keratins 4/13, or in epidermis, marked by keratins 1/10. It is only during pregnancy, that the pure type of nonkeratinizing squamous epithelium is seen by the selective suppression of the epidermal keratins 1/10. This finding and the phenomenon of an unpaired expression of keratin pairs in the human vaginal epithelium are explained by a hormone-dependent synthesis of keratin proteins.
Frauenklinik und Poliklinik, Ludwig-Maximilians-Universität München.
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G
Schaller
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Mischke
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AG
Wild
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002454:Cell Differentiation / Q000502:physiology*; D002979:Climacteric / Q000502:physiology; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis*; D008593:Menopause / Q000502:physiology; D008597:Menstrual Cycle / Q000502:physiology*; D008875:Middle Aged; D011247:Pregnancy / Q000502:physiology; D014621:Vagina / Q000166:cytology*
D007633:Keratins
Das Differenzierungsverhalten des menschlichen Vaginalepithels am Beispiel der Keratinexpression.