Erythrocyte Li-Na countertransport in hypertension: lack of atrial natriuretic peptide effect.
The rate of erythrocyte Li-Na countertransport and cellular Na+ and K+ contents have been determined in normotensive (NT) and hypertensive (HT, essential hypertension) subjects in the presence and absence of atrial natriuretic peptide (ANP). The rate of Li-Na countertransport was significantly higher in erythrocytes of HT subjects, while the Na+ and K+ contents were not different between the NT and HT groups. We found that ANP (10(-9) and 10(-7) M) had no effect on either the rate of Li-Na countertransport or the cellular Na+ and K+ contents. Since ANP does not influence erythrocyte Na pump and Na-K-Cl cotransport, our results suggest that the Na transport systems of human erythrocytes do not respond to ANP and this lack of response in Li-Na countertransport is independent of the status of hypertension. These findings are consistent with the view that the rate of Li-Na countertransport of erythrocytes may serve as a useful genetic marker for essential hypertension in Chinese. However, the erythrocyte transport systems cannot provide further differentiation utilizing ANP response for essential hypertension.
Lau
Y T
YT
Department of Physiology, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan, R.O.C.
Chern
M S
MS
Hung
J S
JS
Liang
H C
HC
Kao
J F
JF
D000328:Adult; D017920:Antiporters; D009320:Atrial Natriuretic Factor / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002352:Carrier Proteins / Q000378:metabolism*; D002681:China / Q000208:ethnology; D004912:Erythrocytes / Q000737:chemistry* / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000378:metabolism*; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism
D017920:Antiporters; D015415:Biomarkers; D002352:Carrier Proteins; C045885:sodium-lithium countertransporter; D009320:Atrial Natriuretic Factor; D011188:Potassium