[The dopamine system in rat brain areas in the early period following irradiation with superhigh doses].
In studying the main indices that characterize the neurochemical system of biosynthesis and degradation of a dopamine neuromediator, tyrosine hydroxylase-dopamine-monoamine oxidase, in different brain regions 5-6 min, 1 and 18 h after whole-body irradiation with high energy electrons (100 Gy) the authors have revealed a 25-40% inhibition of tyrosine hydroxylase and monoamine oxidase activity, and a 40% increase in the dopamine content of basal ganglia of the brain that control behavioural reactions of the organism. The neurochemical disturbances revealed are involved in the mechanisms of early transient incapacity after irradiation with superhigh doses.
Afonin
A N
AN
Ermolaeva
N V
NV
Mazurik
V K
VK
Sorokina
N I
NI
Ushenkova
L N
LN
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects*; D004298:Dopamine / Q000378:metabolism*; D004583:Electrons; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*; D014916:Whole-Body Irradiation
D014446:Tyrosine 3-Monooxygenase; D008995:Monoamine Oxidase; D004298:Dopamine
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