The modulatory effects of phorbol esters on histamine release from mast cells induced by a polyethylenimine and a polyallylamine.
1. Histamine release from rat peritoneal mast cells induced by polyethylenimine (mol. wt = 600) was inhibited by phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), but not by 4 alpha-phorbol 12,13-didecanoate (4 alpha-PDD). 2. Histamine release induced by polyallylamine (mol. wt = 10,000) was enhanced by PMA and PDBu, but not by 4 alpha-PDD. 3. K-252a reduced the inhibitory effect of PMA on histamine release induced by polyethylenimine and its enhancing effect on histamine release by polyallylamine.
Sekino
H
H
Department of Molecular Pharmacology, Meiji College of Pharmacy, Tokyo, Japan.
Uchida
M K
MK
Suzuki-Nishimura
T
T
D000818:Animals; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008970:Molecular Weight; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology; D010703:Phorbol Esters / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology*; D011094:Polyethyleneimine / Q000494:pharmacology*; D011095:Polyethylenes / Q000494:pharmacology*; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D010703:Phorbol Esters; D011073:Polyamines; D011095:Polyethylenes; C008876:phorbol-12,13-didecanoate; C063994:polyallylamine; D015240:Phorbol 12,13-Dibutyrate; D011094:Polyethyleneimine; D011493:Protein Kinase C; D013755:Tetradecanoylphorbol Acetate