[Mediastinal teratocarcinoma and hypophyseal stalk germinoma in a patient with Klinefelter syndrome].
A 8 1/2 year old boy is reported, who was admitted because of rapid growth and premature development of pubic hair. Pseudopubertas praecox was diagnosed, caused by a beta-HCG producing mediastinal teratocarcinoma. The patient also had a pituitary germinoma. His karyotype was 47, XXY. While the association of Klinefelter's syndrome and breast cancer is well known, only recently an increased incidence of mediastinal germ cell tumors in this syndrome has been established, which again is demonstrated in this case report.
Universitäts-Klinderklinik, Mainz.
R
R
König
W
W
Schönberger
W
W
Grimm
D000293:Adolescent; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004407:Dysgerminoma / Q000175:diagnosis*; D006729:Hormones, Ectopic / Q000097:blood*; D006801:Humans; D007713:Klinefelter Syndrome / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D009384:Paraneoplastic Endocrine Syndromes / Q000175:diagnosis; D010446:Peptide Fragments / Q000097:blood*; D010911:Pituitary Neoplasms / Q000175:diagnosis*; D011629:Puberty, Precocious / Q000175:diagnosis; D013724:Teratoma / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006729:Hormones, Ectopic; D010446:Peptide Fragments
Mediastinales Terato-Carzinom und Hypophysenstielgerminom bei einem Patienten mit Klinefelter Syndrom.