Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. II. Structure determination of leuhistin.
Leuhistin, a new inhibitor of aminopeptidase M, has been isolated from the culture broth of Bacillus laterosporus BMI156-14F1. The structure of leuhistin was determined by NMR studies. X-Ray and chemical analysis confirmed the absolute structure to be (2R,3S)-3-amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methylhe xanoic acid.
Institute of Microbial Chemistry, Tokyo, Japan.
S
S
Yoshida
H
H
Naganawa
T
T
Aoyagi
T
T
Takeuchi
Y
Y
Takeuchi
Y
Y
Kodama
D000596:Amino Acids / Q000737:chemistry*; D000626:Aminopeptidases / Q000037:antagonists & inhibitors*; D018826:CD13 Antigens; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D007093:Imidazoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D014961:X-Ray Diffraction
D000596:Amino Acids; D007093:Imidazoles; C069912:leuhistin; D000626:Aminopeptidases; D018826:CD13 Antigens