Putative antigenic domains in glycoprotein G of rabies virus: is the RGK sequence involved in virus adsorption to cellular receptors?
Computer analysis of rabies virus glycoprotein G provides a means for identification of functional domains in the viral glycoprotein. The computer analysis suggested 22 putative antigenic domains, of which three are RG-containing amino acid sequences that might be involved in the binding of rabies virions to cellular receptors. Synthetic RG peptides may be able to interfere with rabies virus adsorption to cellular receptors.
Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
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Becker
D000327:Adsorption; D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D018955:CD36 Antigens; D001330:Electronic Data Processing; D008562:Membrane Glycoproteins / Q000276:immunology*; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011820:Rabies virus / Q000276:immunology*; D016024:Receptors, Cytoadhesin / Q000276:immunology / Q000378:metabolism*; D019699:Thrombospondins; D014764:Viral Proteins / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D018955:CD36 Antigens; D008562:Membrane Glycoproteins; D016024:Receptors, Cytoadhesin; D019699:Thrombospondins; D014764:Viral Proteins