Common and dysplastic naevi as risk factors for cutaneous malignant melanoma in a Swedish population.
Common naevi, dysplastic naevi (DN) and other phenotypic features were evaluated as melanoma risk factors in a Swedish case-control study. One-hundred and twenty-one prevalent melanoma cases and 378 randomly selected controls participated. The mean total body naevus count was 115 in the cases and 67 in the controls. Fifty-six per cent of the cases and 18% of the controls had clinical DN. The corresponding figures for histologically diagnosed DN were 40% and 8% respectively. Clinical DN was as good as histologically diagnosed DN in identifying individuals at risk for melanoma. Subjects with sun-sensitive skin, greater than or equal to 150 naevi and presence of DN have 50 times higher melanoma risk than those without these characteristics.
Augustsson
A
A
Department of Dermatology, Sahlgrenska Hospital, Göteborg, Sweden.
Stierner
U
U
Rosdahl
I
I
Suurküla
M
M
D000328:Adult; D016022:Case-Control Studies; D004416:Dysplastic Nevus Syndrome / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D009506:Nevus / Q000150:complications* / Q000453:epidemiology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology*; D013472:Sunlight / Q000009:adverse effects; D013548:Sweden / Q000453:epidemiology