Effects of glycerol and mannitol on the interstitial fluid pressure of the facial nerve.
The pressure lowering effect of glycerol and mannitol on the interstitial fluid pressure of the facial nerve was studied in normal guinea pigs. The effect of low-molecular dextran on the interstitial fluid pressure of the facial nerve was also studied. Both peroral administration of glycerol and intravenous administration of mannitol lowered the interstitial fluid pressure of the facial nerve as well as the cerebrospinal fluid pressure. The pressure decrease in the facial nerve may be the result of a decreased cerebrospinal fluid pressure, caused by the administration of glycerol or mannitol. Low-molecular dextran did not cause significant pressure changes in the facial nerve.
Department of Otolaryngology, Kochi Medical School, Japan.
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Takeuchi
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Takeda
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Saito
D000818:Animals; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects; D003911:Dextrans / Q000494:pharmacology; D005110:Extracellular Space / Q000187:drug effects*; D005154:Facial Nerve / Q000187:drug effects* / Q000502:physiology; D005500:Follow-Up Studies; D005990:Glycerol / Q000494:pharmacology*; D006168:Guinea Pigs; D008353:Mannitol / Q000494:pharmacology*; D008970:Molecular Weight
D003911:Dextrans; D008353:Mannitol; D005990:Glycerol