[The role of axonal transport in regulating the chemosensitivity of muscle spindles in the cat].
The effects of acetylcholine, subecholine and succinylcholine on the afferent activity of the m.EDL muscle spindles were compared before and after suppression of axonal transport by colchicine (20 nM, 30 min). The colchicine increased cholinergic sensitivity of nuclear-bag fibres: i. a. administration of cholinergic substances at concentrations tenfold lower than in control animals, produced a sharp enhancement of afferent activity of the muscle spindles. The increase of chemosensitivity was maximal to Ach and less obvious for subecholine and succinylcholine. No increase of activity could be produced by cholinomimetics in afferents originating from nuclear-chain fibres either in control, or after suppression of axonal transport.
R S
RS
Arutiunian
T L
TL
Radziukevich
D000109:Acetylcholine / Q000494:pharmacology; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001370:Axonal Transport / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D002794:Choline / Q000031:analogs & derivatives / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009470:Muscle Spindles / Q000187:drug effects* / Q000502:physiology; D013390:Succinylcholine / Q000494:pharmacology
C009335:subecholine; D013390:Succinylcholine; D002794:Choline; D000109:Acetylcholine; D003078:Colchicine
Rol' aksonal'nogo transporta v reguliatsii khemochuvstvitel'nosti myshechnykh vereten koshki.