Urinary dolichol--a doubtful marker of alcoholism.
The purpose of this study was to replicate the results of Pullarkat and Raguthu and Roine et al. who found elevated levels of urinary dolichol (long-chain 2,3-dihydropolyprenols) in chronic alcoholic patients. We investigated a sample of 21 alcohol-dependent inpatients voluntarily entering detoxification treatment. Urinary dolichol was only slightly increased as compared to 21 healthy controls. When dolichol was related to urinary creatinine no differences between alcoholic patients and controls could be found. Under conditions of confirmed abstinence the slightly elevated levels of dolichol returned to normal within 2 weeks. Compared with the sensitivity of gamma-glutamyltransferase which ranges from 72-85%, the value of urinary dolichol (sensitivity 9-19%) as a biochemical marker of alcoholism must be doubted.
Department of Psychiatry, University of Tübingen, Federal Republic of Germany.
F
F
Stetter
H J
HJ
Gaertner
G
G
Wiatr
K
K
Mann
U
U
Breyer-Pfaff
D000328:Adult; D000437:Alcoholism / Q000175:diagnosis* / Q000201:enzymology / Q000534:rehabilitation; D003404:Creatinine / Q000652:urine; D004286:Dolichols / Q000652:urine*; D000431:Ethanol / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D005723:gamma-Glutamyltransferase / Q000097:blood
D004286:Dolichols; D000431:Ethanol; D003404:Creatinine; D005723:gamma-Glutamyltransferase