Insulin-like growth factors and their binding proteins: review of functions and clinical applications.
Insulin-like Growth Factors I & II (IGFs I & II) circulate in a concentration 1000 times that of insulin. The effect of these growth factors appears to be regulated by their binding proteins. The clinical usefulness of the IGFs resides currently in the growth hormone disease states and their treatment, as well as tumour related hypoglycemia. The growth hormone dependent binding protein (mol. wt 53kD) appears to possess a role in growth disorders, whereas the growth hormone independent binding protein (mol. wt 28kD) has recently been found to exert a role in glucose homeostasis.
Department of Medicine I, Singapore General Hospital.
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Yeoh
D000172:Acromegaly / Q000097:blood / Q000209:etiology; D000293:Adolescent; D002352:Carrier Proteins / Q000378:metabolism*; D002648:Child; D004392:Dwarfism / Q000097:blood / Q000209:etiology; D006131:Growth Inhibitors; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D007335:Insulin-Like Growth Factor II / Q000032:analysis* / Q000378:metabolism; D015282:Octreotide / Q000627:therapeutic use*
D002352:Carrier Proteins; D006131:Growth Inhibitors; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D015282:Octreotide