Peripheral benzodiazepines potentiate the effect of adenosine in rat vas deferens.
Ro 5-4864, diazepam, clonazepam and PK 11195 inhibit the responses of rat was deferens following electrical stimulation in the rank order Ro 5-4864 greater than PK 11195 = diazepam greater than clonazepam. The adenosine-inhibited electrically-induced response was potentiated by Ro 5-4864 or diazepam, but not by clonazepam or PK 11195. This potentiation is due to an inhibition of the adenosine uptake system.
Escubedo
E
E
Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Spain.
Camarasa
J
J
Pallas
M
M
Adzet
T
T
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D004357:Drug Synergism; D004558:Electric Stimulation; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014649:Vas Deferens / Q000187:drug effects
D001570:Benzodiazepinones; D007546:Isoquinolines; D001569:Benzodiazepines; C028513:4'-chlorodiazepam; D000241:Adenosine; C037850:PK 11195