Percolation model of ionic channel dynamics.
The nonexponential closed-time distributions observed for ionic channels have been explained recently by quasi-one-dimensional models of structural diffusion (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988. Proc. Natl. Acad. Sci. USA. 85: 1503-1507; Condat, C. A., and J. Jäckle. 1989. Biophys. J. 55: 915-925; Levitt, D. G. 1989. Biophys. J. 55: 489-498). We generalize this treatment by allowing for more complex trajectories using percolation theory. We assume that the gating transition depends on marginally connected conformational states leading to the observed spread in time scales.
Doster
W
W
Technische Universität München, Physik-Department E13, Federal Republic of Germany.
Schirmacher
W
W
Settles
M
M
D003198:Computer Simulation; D004058:Diffusion; D006860:Hydrogen Bonding; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D008954:Models, Biological
D007473:Ion Channels