[Possibility of the treatment of tuberculosis with delayed-action polymeric isoniazid].
In vitro destruction of carboxymethylcephades (CMC) polymer, its based polymer isoniazid produced, and the in vivo remedial and long effect of the latter on a tuberculous process were studied. It was found that a polymer isoniazid in blood plasma gradually degraded by 80% within 5-6 days. The experiments on animals demonstrated a minimum reactive action of CMC capable of gradually biodegrading in the tissues. A possible treatment of tuberculosis with a polymer isoniazid administered once every week is shown.
Turkebaeva
K A
KA
Shipunova
O V
OV
Krivtsova
A E
AE
Moshkevich
S A
SA
Zhubanov
B A
BA
D000818:Animals; D001672:Biocompatible Materials; D003911:Dextrans; D004353:Drug Evaluation, Preclinical; D004343:Drug Implants; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007538:Isoniazid / Q000008:administration & dosage*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D001672:Biocompatible Materials; D003911:Dextrans; D004343:Drug Implants; C014392:carboxymethyl dextran; D007538:Isoniazid
O vozmozhnosti lecheniia tuberkuleza polimernym izoniazidom prolongirovannogo deĭstviia.