Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia.
To find out whether a serum factor in pre-eclamptic women is the cause of the raised serum endothelin concentrations associated with the disorder, the effect of serum from pre-eclamptic women on endothelin production by endothelial cells was compared with that of serum from pregnant and non-pregnant controls. The finding that pre-eclamptic serum suppresses endothelin production suggests that it contains a factor that might be part of a homoeostatic response to raised serum endothelin concentrations in pre-eclampsia.
Branch
D W
DW
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City.
Dudley
D J
DJ
Mitchell
M D
MD
D015121:6-Ketoprostaglandin F1 alpha / Q000032:analysis; D000293:Adolescent; D000328:Adult; D016232:Endothelins / Q000096:biosynthesis*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use; D011225:Pre-Eclampsia / Q000097:blood* / Q000517:prevention & control; D011247:Pregnancy; D013917:Thrombin / Q000032:analysis
D016232:Endothelins; D015121:6-Ketoprostaglandin F1 alpha; D008278:Magnesium Sulfate; D013917:Thrombin