Thyrotoxicosis induced sick sinus syndrome: medical therapy may avoid permanent pacing.
A 65-year-old white female developed sick sinus syndrome associated with thyrotoxicosis which resolved upon achieving a euthyroid state, thus obviating the need for permanent pacemaker implantation. TSH was less than 0.1 ng/dL, and 24-hour iodine uptake was 28%. After correction of the hyperthyroid state with propylthiouracil and potassium iodine, sinoatrial pauses up to 6 seconds resolved over 10 days. A subsequent sinus node recovery time was normal and no symptoms recurred over 22 months.
Lubitz
R M
RM
Department of Medicine, University of Tennessee Medical Center, Knoxville 37920.
Acker
J J
JJ
D000368:Aged; D005260:Female; D006801:Humans; D010138:Pacemaker, Artificial; D011193:Potassium Iodide / Q000627:therapeutic use; D011441:Propylthiouracil / Q000627:therapeutic use; D012804:Sick Sinus Syndrome / Q000209:etiology* / Q000628:therapy; D013971:Thyrotoxicosis / Q000150:complications*
D011193:Potassium Iodide; D011441:Propylthiouracil