Vascular selectivity of felodipine: clinical experience.
Felodipine is a new calcium antagonist with vascular selectivity. It has a high potency in arterial resistance vessels and no apparent action on capacitance vessels. It lacks significant effects on myocardial contractility and cardiac conduction. It is an effective antihypertensive agent and may be safely combined with beta-adrenoceptor blockade. This report outlines work confirming the vascular selectivity of felodipine by examining its clinical effects in hypertension, ischemic heart disease, and congestive heart failure.
Thomas
P
P
Department of Cardiology, St. Mary's Hospital Medical School, London, England.
Sheridan
D J
DJ
D000818:Animals; D015736:Felodipine / Q000494:pharmacology / Q000627:therapeutic use*; D006321:Heart / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009928:Organ Specificity; D014655:Vascular Resistance / Q000187:drug effects
D015736:Felodipine