Lindane-induced liver oxidative stress.
The development of an oxidative stress condition in the liver by lindane intoxication is discussed as a possible hepatotoxic mechanism of the insecticide. Lindane is metabolized by liver microsomal enzymes to a variety of metabolites, which are susceptible of conjugation for proper elimination. In addition, the interaction of lindane with the liver tissue results in the induction of the microsomal cytochrome P-450 system, together with enhanced rates of superoxide radical generation and a significant increase in indicators of lipid peroxidation. Concomitantly, lindane intoxication induces a derangement of some antioxidant mechanisms of the liver cell, including decreased superoxide dismutase and catalase activities and alterations in reduced glutathione content leading to depressed GSH/GSSG ratios. The time course study of the changes in hepatic lipid peroxidation and antioxidant parameters are closely interrelated and coincide with the onset and progression of morphological lesions.
Videla
L A
LA
Department of Biological Sciences, Faculty of Medicine, University of Chile, Santiago.
Barros
S B
SB
Junqueira
V B
VB
D000818:Animals; D000975:Antioxidants; D005609:Free Radicals; D001556:Hexachlorocyclohexane / Q000506:poisoning*; D015227:Lipid Peroxidation; D008862:Microsomes, Liver / Q000378:metabolism* / Q000473:pathology; D010100:Oxygen / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D001556:Hexachlorocyclohexane; D010100:Oxygen