Inhibitory effect of 2,3-dibenzylbutane-1,4-diol; a mammalian lignan, on the CA2+ channel in rabbit femoral artery.
2,3-Dibenzylbutane-1,4-diol (DBB) is a mammalian lignan derived from human urine. To investigate the pharmacological actions of mammalian lignans, the effects of DBB on high K(+)-induced contraction in rabbit femoral artery were studied. High K+ induced a transient contraction followed by sustained contraction, and both depended on extracellular Ca2+. DBB inhibited transient contraction as well as sustained contraction. Verapamil or nifedipine inhibited sustained contraction more effectively than transient contraction. DBB inhibited the transient contraction remaining in the verapamil- or the nifedipine-pretreated preparation in a concentration-dependent manner. Moreover, DBB inhibited sustained contraction elicited by Bay K 8644 (Ca2+ channel activator). These results indicate that DBB effects not only the sensitive Ca2+ channels but also the insensitive channels.
Department of Pharmacology, Tokyo College of Pharmacy, Japan.
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Abe
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Morikawa
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Inoue
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Tsuboi
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism*; D005263:Femoral Artery / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D012433:Ryanodine / Q000494:pharmacology
D001593:Benzyl Compounds; D002121:Calcium Channel Blockers; D015220:Calcium Channels; C063012:2,3-dibenzylbutane-1,4-diol; D012433:Ryanodine; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D011188:Potassium