The inhibiting effect of cetirizine 2 HC1 on eosinophil migration and its link to H1 blockade.
Since the demonstration of an inhibiting effect of cetirizine on an antigen induced eosinophils' migration in the skin of atopic subjects, a series of in vitro and in vivo studies were performed in order to clarify the mechanism of action of this new H1-blocker. The studies used FMLP and PAF as agonists, and BN 52021, dexchlorpheniramine, terfenadine and loratadine as reference compounds. The results suggest that the inhibiting effect of cetirizine on the eosinophils' migration is independent of its specific H1 blocking activity.
Rihoux
J P
JP
International Product Development Department UCB S.A Chemin du Foriest, Braine l'Alleud, Belgium.
D017332:Cetirizine; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004804:Eosinophils / Q000187:drug effects / Q000502:physiology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000502:physiology; D012867:Skin / Q000166:cytology
D006634:Histamine H1 Antagonists; D010972:Platelet Activating Factor; D011969:Receptors, Histamine H1; D006919:Hydroxyzine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D017332:Cetirizine