[The efficacy of rheopolyglucin-based blood correctors in acute blood loss in rats].
The efficacy of rheopolyglucin and complex blood correctors based on it was demonstrated in experiments on 86 albino male rats. The main renal functions (glomerular filtration and tubular secretion), determined by radionuclide methods, were restored by means of infusion therapy. The effect was produced by the complex action exerted on the main pathogenetic mechanisms of the process. Rheopolyglucin injected into intact rats and rats subjected to blood loss led to a certain increase of the blood histamine level, but did not induce a shock-like reaction. Infusion of an equal volume of isotonic sodium chloride solution was also accompanied with hyperhistaminemia in some of the rats.
Levin
G S
GS
Baĭdullaev
Sh T
ShT
Shibunskaia
S S
SS
Zhuravleva
Zh G
ZhG
D000208:Acute Disease; D000818:Animals; D003911:Dextrans / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D051381:Rats
D003911:Dextrans; D006632:Histamine
Effektivnost' gemokorrektorov na osnove reopoligliukina pri ostroĭ krovopotere u krys.