Cardiovascular effects of SKF 104078 in lambs.
We studied the effects of SKF 104078 in anesthetized, newborn lambs and compared it to nonspecific alpha-receptor blockade by tolazoline. SKF 104078 infusion decreased pulmonary and systemic arterial pressures in newborn lambs when infused during normoxic ventilation. When infused during hypoxia, SKF 104078 decreased cardiac output and systemic blood pressure without affecting pulmonary pressure. Due to the predominance of systemic effects, the usefulness of SKF 104078 in states of hypoxic pulmonary vasoconstriction is limited.
Harbor-UCLA Medical Center, Torrance.
B
B
Chappell
J
J
Padbury
A
A
Martinez
D
D
Habib
H
H
Stein
K
K
Oyama
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001552:Benzazepines / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D000860:Hypoxia / Q000188:drug therapy; D007261:Infusions, Intra-Arterial; D011652:Pulmonary Circulation / Q000187:drug effects; D012756:Sheep; D014043:Tolazoline / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D001552:Benzazepines; C054935:SK&F 104078; D014043:Tolazoline