CSF somatostatin in childhood psychiatric disorders: a preliminary investigation.
Disruptive behavior disorders and obsessive-compulsive disorder have been associated with serotonergic dysfunction as well as particular body habitus findings in pediatric patients. Somatostatin, a peptide which stimulates serotonin release and inhibits growth hormone release, was measured in the cerebrospinal fluid (CSF) of 10 children with disruptive behavior disorders and in 10 age-, sex-, and race-matched pairs of obsessive-compulsive disorder patients. Decreased concentrations of somatostatin were found in disruptive behavior disorder patients relative to obsessive-compulsive children, even after controlling for differences in Tanner stage. In contrast to studies in adults, those patients in a depressed state did not have lower CSF somatostatin concentration.
Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
M J
MJ
Kruesi
S
S
Swedo
H
H
Leonard
D R
DR
Rubinow
J L
JL
Rapoport
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000134:cerebrospinal fluid; D002648:Child; D002653:Child Behavior Disorders / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D003866:Depressive Disorder / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000134:cerebrospinal fluid* / Q000175:diagnosis
D006897:Hydroxyindoleacetic Acid