The serum hormone levels, phosphate complex concentrations and enzyme activities in haemodialysed and kidney-transplanted children.
The serum hormone (T3, FT3, T4, FT4, TSH, hTG, a-hTG, GH, PTH, PRL, Cortisol) concentrations, the inorganic phosphate complexes (HPO2-4, H2PO-4, NaHPO-4, KHPO-4, CaHPO4, MgHPO4) and the enzyme activities (Amylase, Lipase, AP, ACE, GOT, GPT, psi-ChE, CK, gamma-GT, LDH) were investigated in 13 haemodialysed children, 7 kidney-transplanted children and in 15 healthy controls. This study confirmed that the kidney plays an important role in the metabolism of hormones. Prior to kidney transplantation 8 of the 11 tested hormone levels of haemodialysed children significantly differed from those of healthy controls, however, after kidney transplantation only two parameters did. The effect of dialysis is the least on the CaHPO4 complex among the different inorganic phosphate complexes. This may play a role in vascular calcification in chronic renal failure patients. The amylase and lipase activity were elevated in haemodialysed group, while in kidney-transplanted children the angiotensin converting enzyme (ACE) and alkaline phosphatase (AP) differed from those of the control group.
First Department of Paediatrics, Semmelweis University Medical School, Budapest, Hungary.
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Szabó
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Sallay
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Tausz
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000681:Amylases / Q000097:blood; D002648:Child; D005260:Female; D006728:Hormones / Q000097:blood* / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000201:enzymology*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000201:enzymology / Q000628:therapy; D016030:Kidney Transplantation; D008049:Lipase / Q000097:blood; D008297:Male; D008970:Molecular Weight; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D010710:Phosphates / Q000097:blood*; D006435:Renal Dialysis; D013997:Time Factors
D006728:Hormones; D010710:Phosphates; D008049:Lipase; D000469:Alkaline Phosphatase; D000681:Amylases; D007703:Peptidyl-Dipeptidase A