Towards a molecular understanding of T-cell differentiation.
Lymphoid differentiation is one of the best studied examples of mammalian development. Here Hans Clevers and Michael Owen describe how the cloning of the genes that encode T-cell-specific membrane proteins allows the identification of transcription factors that control the expression of these T-cell genes. Such transcription factors play a key role in the development of the mature T-cell phenotype by functioning as 'master regulators of T-cell differentiation'.
Clevers
H C
HC
Dept. of Clinical Immunology, University Hospital Utrecht, The Netherlands.
Owen
M J
MJ
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000096:biosynthesis / Q000235:genetics*; D001483:Base Sequence; D018801:CD2 Antigens; D017252:CD3 Complex; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D005810:Multigene Family; D009928:Organ Specificity; D011487:Protein Conformation; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics; D012045:Regulatory Sequences, Nucleic Acid; D013329:Structure-Activity Relationship; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes / Q000166:cytology*; D014157:Transcription Factors / Q000502:physiology
D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D017252:CD3 Complex; D004268:DNA-Binding Proteins; D011948:Receptors, Antigen, T-Cell; D011971:Receptors, Immunologic; D014157:Transcription Factors