Antigen-presenting activity of non-Langerhans epidermal cells in contact hypersensitivity reactions.
Despite the critical role of the Langerhans cells in the induction of contact hypersensitivity reactions, non-Langerhans antigen-presenting cells in already sensitized individuals may play a role in the elicitation phase of a contact hypersensitivity reaction. Following epicutaneous challenge with antigens, the number of CD1+DR+ epidermal Langerhans cells increased in a time-dependent way and, concomitantly, CD1-OKM5+DR+ epidermal non-Langerhans cells appeared. In parallel with this, the capacity of epidermal cells to present both alloantigens and auto/nominal antigens increased, and 4 days after initiation of the contact hypersensitivity reactions 33-53% of the epidermal antigen-presenting capacity was due to CD1- non-Langerhans antigen-presenting cells. Thus, contact hypersensitivity skin reactions are accompanied by the appearance of non-Langerhans antigen-presenting cells capable of presenting both alloantigens and auto/nominal antigens.
Baadsgaard
O
O
Department of Dermatology, Bispebjerg Hospital, Denmark.
Lisby
S
S
Avnstorp
C
C
Clemmensen
O
O
Lange-Vejlsgaard
G
G
D000485:Allergens / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology*; D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1; D000943:Antigens, Differentiation / Q000032:analysis; D018955:CD36 Antigens; D003877:Dermatitis, Contact / Q000276:immunology* / Q000473:pathology; D004817:Epidermis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology / Q000502:physiology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D000485:Allergens; D015703:Antigens, CD; D018949:Antigens, CD1; D000943:Antigens, Differentiation; D018955:CD36 Antigens; D006684:HLA-DR Antigens