Functional subsets of allergen-reactive human CD4+ T cells.
After a period of resistance, the concept of human helper T (TH)-cell subsets is gaining currency. This is the result of analyses from a number of laboratories on the cytokine profiles of T-cell clones prepared from chronically-infected and hypersensitive individuals. Here, Martien Kapsenberg and colleagues summarize these studies and speculate on the significance of skewed TH1 and TH2 responses.
Laboratory of Cell Biology and Histology, Academisch Medisch Centrum, Amsterdam, The Netherlands.
M L
ML
Kapsenberg
E A
EA
Wierenga
J D
JD
Bos
H M
HM
Jansen
D000485:Allergens / Q000276:immunology*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007378:Interleukins / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000485:Allergens; D007378:Interleukins; D008222:Lymphokines