[Resection of carcinoid tumors of the small intestine is still indicated in the presence of disseminated hepatic metastases].
The authors report their experience with resection of small bowel carcinoid tumors associated with diffuse hepatic metastases. Nine patients were operated during the last ten years. A carcinoid syndrome was present biologically in every case and clinically in 8 cases. The tumor was removed in every case, either by right hemicolectomy (n = 6), or by small bowel resection (n = 3). Postoperative mortality and morbidity were nil. Adjuvant therapy included hepatic chemo-embolization and long-term therapy by a long-acting somatostatin analog. Five patients died during the period of follow-up and 4 patients were alive at the end of the study. Resection of small bowel carcinoid tumor is indicated even when the liver is involved by diffuse metastases to prevent the risk of small bowel occlusion, and to promote hepatic chemoembolization as subsequent therapy against the carcinoid syndrome and metastatic spread. Moreover, the procedure can participate in the selection of cases for orthotopic liver transplantation, when conservative therapy fails to control the carcinoid syndrome.
Service de Chirurgie Digestive, Hôpital E. Herriot, Lyon.
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C
Partensky
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Landraud
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Velecela
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JC
Souquet
D000368:Aged; D002276:Carcinoid Tumor / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D007414:Intestinal Neoplasms / Q000473:pathology / Q000601:surgery*; D007421:Intestine, Small / Q000601:surgery*; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid
L'exérèse des tumeurs carcinoïdes de l'intestin grêle reste indiquée en présence de métastases hépatiques diffuses.