A single point mutation in the seventh hydrophobic domain of the alpha 2-adrenergic receptor changes antagonist binding specificity to that of a beta receptor.
Suryanarayana
S
S
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University, CA 94305.
Daunt
D A
DA
Von Zastrow
M
M
Kobilka
B K
BK
D000317:Adrenergic alpha-Antagonists / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation; D011942:Receptors, Adrenergic, alpha / Q000235:genetics* / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000235:genetics / Q000378:metabolism
D000317:Adrenergic alpha-Antagonists; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta