Clinical programs for clinical research on AIDS: description of a randomized prospective study of clindamycin versus pyrimethamine for prevention of Toxoplasma gondii infection.
The risk of toxoplasmic encephalitis complicating AIDS appears largely limited to those HIV-infected patients with serologic evidence of past Toxoplasma gondii infection and low CD4 lymphocyte counts. The Community Programs for Clinical Research on AIDS has initiated a randomized, placebo-controlled trial to determine if clindamycin or pyrimethamine prophylactic regimens are effective and safe in preventing toxoplasmic encephalitis.
Jacobson
M A
MA
San Francisco Community Consortium on AIDS, CA.
Besch
C L
CL
Child
C
C
Hafner
R
R
Muth
K
K
Deyton
L
L
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D015496:CD4-Positive T-Lymphocytes; D002981:Clindamycin / Q000627:therapeutic use*; D004660:Encephalitis / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007958:Leukocyte Count; D011446:Prospective Studies; D011739:Pyrimethamine / Q000627:therapeutic use*; D012307:Risk Factors; D014123:Toxoplasmosis / Q000209:etiology / Q000517:prevention & control*
D002981:Clindamycin; D011739:Pyrimethamine