Protective role of chlorpromazine on lead-induced damage to heart mitochondria.
1. The protective effect of chlorpromazine (CPZ) on the toxic effects of lead in mitochondrial functions was studied. 2. The findings indicate that CPZ at a concentration of 50 microM protects heart mitochondria against lead-induced Ca2+ uptake inhibition. 3. In addition, CPZ inhibits the drop of the transmembrane potential, as well as mitochondrial swelling as induced by 10 microM Pb2+. 4. It is proposed that the protective effect of chlorpromazine can be due to its stabilizing action on biological membranes.
Castaño
R
R
Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, México.
Culebras
C
C
Zazueta
C
C
Chávez
E
E
D000818:Animals; D002118:Calcium / Q000037:antagonists & inhibitors / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000009:adverse effects*; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D007854:Lead; D002118:Calcium; D002746:Chlorpromazine