Intracellular regulation of ion channels in cell membranes.
Cells communicate with their environment through receptor proteins on the cell membrane. Some ion channels are receptors, whereas others are linked to receptors through guanine nucleotide-binding proteins (G proteins). Ion channels control intracellular concentrations of ions such as calcium, and these concentrations control cell functions such as secretion and cell division. This review summarizes the current state of knowledge about the control of ion channels.
Lewis
D L
DL
Department of Pharmacology, Mayo Clinic, Rochester, MN 55905.
Lechleiter
J D
JD
Kim
D
D
Nanavati
C
C
Clapham
D E
DE
D002450:Cell Communication; D002462:Cell Membrane / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D015290:Second Messenger Systems
D007473:Ion Channels; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins