Inhibition of lipid peroxidation by methylated analogues of uric acid.
The effects of purines and methylated purine analogues on hydrogen peroxide- and ozone-induced lipid peroxidation in human erythrocyte membranes were studied in-vitro. Many purines and purine analogues showed a suppressive effect on the formation of thiobarbituric acid reactive materials. 1,3-Dimethyluric acid and 1,3,7-trimethyluric acid showed high potency in prevention of lipid peroxidation. These effects were shown to be concentration dependent and were more potent at low concentrations of hydrogen peroxide and ozone. 1,3-Dimethyluric acid and 1,3,7-trimethyluric acid may be useful as antioxidants.
Health Administration Center, Tokyo University of Foreign Studies, Japan.
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Nishida
D000975:Antioxidants / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000633:toxicity; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008745:Methylation; D010126:Ozone / Q000633:toxicity; D011687:Purines / Q000138:chemical synthesis / Q000494:pharmacology; D013858:Thiobarbiturates; D014527:Uric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000975:Antioxidants; D011687:Purines; D013858:Thiobarbiturates; D014527:Uric Acid; D010126:Ozone; D006861:Hydrogen Peroxide