Tamoxifen in the management of advanced breast carcinoma in Nigerian women.
Twenty-nine Nigerian women with advanced breast carcinoma treated with Tamoxifen (Nolvadex ICI) at a dosage of 20 mg twice daily have been reviewed. Eight of 26 evaluable patients had objective response (31%). No statistically significant association was found between response rate and menopausal status, previous chemotherapy or disease free interval. The drug was well tolerated with a low incidence of side effects. This study suggests that Tamoxifen is a useful drug in the adjuvant management of patients with advanced breast carcinoma in Nigeria.
Department of Surgery, University College Hospital, Ibadan, Nigeria.
R O
RO
Senbanjo
F N
FN
Ihekwaba
O O
OO
Ajayi
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009549:Nigeria; D010166:Palliative Care / Q000592:standards; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D013629:Tamoxifen