Restriction fragment length polymorphisms, glucocorticoid receptors, and phenytoin-induced cleft palate in congenic strains of mice with steroid susceptibility differences.
A gene that affects susceptibility to cortisone-induced cleft palate maps between H-2S and H-2D on mouse chromosome 17. Congenic mouse strains that differ at this locus, designated Cps-1 (cleft palate susceptibility-1), have been tested for the presence of several closely linked markers. All data obtained so far are consistent with a gene order of H-2S-Cps-1-BAT-5-BAT-2-TNF-H-2D. The Cps-1 gene does not appear to affect the level of glucocorticoid receptors or the susceptibility of mice to phenytoin-induced cleft palate.
Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104.
D L
DL
Gasser
A
A
Goldner-Sauvé
M
M
Katsumata
A S
AS
Goldman
D000818:Animals; D015415:Biomarkers; D015139:Blotting, Southern; D002972:Cleft Palate / Q000139:chemically induced* / Q000235:genetics*; D003434:Crossing Over, Genetic; D005260:Female; D006084:Graft Rejection / Q000235:genetics; D006183:H-2 Antigens / Q000235:genetics; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D010672:Phenytoin / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011965:Receptors, Glucocorticoid / Q000096:biosynthesis*; D016038:Skin Transplantation; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D015415:Biomarkers; D006183:H-2 Antigens; D011965:Receptors, Glucocorticoid; D014409:Tumor Necrosis Factor-alpha; D010672:Phenytoin