Blockade of the 3,4-methylenedioxymethamphetamine-induced changes in neurotensin and dynorphin A systems.
The levels of neurotensin-like immunoreactivity (NTLI) and dynorphin-like immunoreactivity (DLI) in the neostriatum, nucleus accumbens and substantia nigra were increased 18 h after a single administration of MDMA (3,4-methylenedioxymethamphetamine, 10 mg/kg). Coadministration of SCH 23390, a dopamine D1 receptor antagonist, or MK-801, a non-competitive antagonist of the NMDA (N-methyl-D-aspartate) receptor complex, prevented the MDMA-induced increase of NTLI and DLI in all three brain structures while the administration of sulpiride, a dopamine D2 receptor antagonist, failed to alter the MDMA effects. These findings suggest that MDMA-induced changes in neurotensin and dynorphin involve both the dopaminergic and the glutamatergic systems.
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112.
M
M
Johnson
L G
LG
Bush
J W
JW
Gibb
G R
GR
Hanson
D015104:3,4-Methylenedioxyamphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001921:Brain / Q000378:metabolism / Q000648:ultrastructure; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018492:Dopamine Antagonists; D004399:Dynorphins / Q000378:metabolism / Q000502:physiology*; D005116:Extrapyramidal Tracts / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008032:Limbic System / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D008297:Male; D009496:Neurotensin / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D017981:Receptors, Neurotransmitter / Q000502:physiology; D013469:Sulpiride / Q000494:pharmacology
D001552:Benzazepines; D018492:Dopamine Antagonists; D011954:Receptors, Dopamine; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; D009496:Neurotensin; D015104:3,4-Methylenedioxyamphetamine; D016291:Dizocilpine Maleate; D004399:Dynorphins; D013469:Sulpiride