Familial hypotrichosis of the scalp. Autosomal dominant inheritance in four generations.
We describe a Danish family of four generations suffering from hypotrichosis of the scalp. Age at onset was 6-17 years and almost total scalp alopecia was reached by the age of 14-21 years. No associated ectodermal defects were present. Nine of 22 persons covering four generations were affected. Growth of the scalp hair slowly decreased and was accompanied by a gradual, diffuse hair loss without regional variation. A scalp biopsy was performed, revealing a non-scarring alopecia with features of androgenetic alopecia. The pedigree was compatible with autosomal dominant inheritance.
Department of Dermatology, Odense University Hospital, Denmark.
H H
HH
Ibsen
O J
OJ
Clemmensen
F
F
Brandrup
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002648:Child; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D006197:Hair / Q000473:pathology; D006801:Humans; D007039:Hypotrichosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D010375:Pedigree; D012535:Scalp / Q000473:pathology*