Binding and production of insulin-like growth factor-I in rat mammary gland.
1. Mammary tissue from pregnant rat presents low and high affinity IGF-I functional receptors. 2. Mammary explants from pregnant and lactating rats secrete IGF-I and its production was related to the developmental stage of the gland. 3. An inverse relationship between IGF-I production and tissue binding capacity was observed.
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago.
S
S
Lavandero
J F
JF
Santibáñez
M P
MP
Ocaranza
A
A
Ferreira
M
M
Sapag-Hagar
D000818:Animals; D001667:Binding, Competitive; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000378:metabolism*; D009924:Organ Culture Techniques; D011247:Pregnancy; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature
D007334:Insulin-Like Growth Factor I