Adjunctive clonazepam in the treatment of chronic schizophrenia.
Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features. Manic symptoms improved but returned following discontinuation of clonazepam. The drug appears to benefit positive psychotic symptoms but worsens negative symptoms.
Mount Sinai School of Medicine, Elmhurst Hospital Center, N.Y.
J M
JM
Herrera
W A
WA
Alvarez
J P
JP
Freinhar
W B
WB
Lawson
J J
JJ
Sramek
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D002998:Clonazepam / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D016037:Single-Blind Method
D014150:Antipsychotic Agents; D002998:Clonazepam