[Evaluation of dopaminergic activity of the hypothalamus in patients with polycystic ovarian syndrome].
To evaluate the hypothalamic dopaminergic activity in patients with polycystic ovary syndrome (PCOS), we studied the PRL, TSH, LH and FSH responses to i.m. administration of sulpiride in five euthyroid women affected by PCOS and in five normal women. The mean basal PRL and TSH plasma levels resulted significantly higher (p less than 0.01) in PCOS subjects with respect to normal subjects. The incremental area under PRL and TSH profiles, after sulpiride administration, were significantly lower (p less than 0.05) in PCOS patients than in the control group; no significant variation of LH and FSH plasma levels resulted. Our data suggest a decrease dopaminergic activity in PCOS.
Cattedra di Endocrinologia, Università di Modena.
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D015259:Dopamine Agents / Q000378:metabolism*; D004341:Drug Evaluation; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D013469:Sulpiride / Q000008:administration & dosage* / Q000494:pharmacology; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood
D015259:Dopamine Agents; D013963:Thyroid Hormones; D013469:Sulpiride; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin
Valutazione del tono dopaminergico ipotalamico in pazienti con sindrome dell'ovaio policistico.