Amoxicillin-clavulanate prophylaxis against wound infections after clean-contaminated surgery. A controlled, randomized, prospective study.
In a single-blind, prospective randomized and controlled trial, amoxicillin-clavulanate was compared with gentamicin plus clindamycin as perioperative prophylaxis for 24 hours in clean-contaminated abdominal surgery. Proven infections of the abdominal incision occurred in one of 59 evaluable patients given amoxicillin-clavulanate and one of 43 with gentamicin/clindamycin. In the latter group there was also one incisional perineal wound infection. At follow-up enquiry by telephone around postoperative day 30, four patients in the amoxicillin-clavulanate group reported minor wound discharge for which they had not sought medical attention. Intraperitoneal infection occurred in one patient of that group, and in three of the gentamicin/clindamycin group. Both regimens thus were effective and safe as prophylaxis in clean-contaminated abdominal surgery.
Department of Clinical Microbiology, University Hospital, Utrecht, The Netherlands.
A
A
Weersink
M
M
Visser
A
A
Vos
P
P
Hulstaert
I
I
ten Berge
M
M
Muijsken
T
T
van Vroonhoven
J
J
Verhoef
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000627:therapeutic use*; D019980:Amoxicillin-Potassium Clavulanate Combination; D002969:Clavulanic Acids / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use; D013505:Digestive System Surgical Procedures; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D016037:Single-Blind Method; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*; D014945:Wound Healing
D002969:Clavulanic Acids; D005839:Gentamicins; D002981:Clindamycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin