[Neuromediator analysis of sleep, analgesia and amnesia--components of general anesthesia with ketamine and thiopental sodium].
In experiments on rats the involvement of neuromediator systems into the development of outer manifestations of general anesthesia with ketamine and thiopental sodium was determined by the ability of neuromediator analyzers to change significantly their absolute values. The role of neuromediator mechanisms in general ketamine anesthesia can be determined by opiate-, serotonin-, GABA- and alpha 2-adrenomimetic, as well as alpha 1 and beta-adrenoblocking, anti-dopamine and anticholinergic properties of the anesthetic. The role of neuromediator systems in general anesthesia with thiopental sodium is determined by GABA-mimetic, antiadrenergic (alpha 2-agonist and alpha 1- and beta-adrenoceptor antagonist), anticholinergic and antidopaminergic properties of the thiobarbiturate.
Mamchur
V I
VI
D000647:Amnesia; D000698:Analgesia; D000768:Anesthesia, General; D000818:Animals; D007649:Ketamine; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000502:physiology; D013874:Thiopental
D018377:Neurotransmitter Agents; D007649:Ketamine; D013874:Thiopental
Neĭromediatornyĭ analiz sna, analgezii i amnezii--komponentov obshcheĭ anestezii ketaminom i tiopental-natriem.