Auditory evoked potentials from the primary auditory cortex of the cat: topographic and pharmacological studies.
Wave VI (8.4 msec) of the brain-stem auditory evoked potential (BAEP) was maximal in a discrete region of primary auditory cortex (AI) of the anesthetized cat. Wave VI underwent rapid amplitude decrease over millimeter distances in the AI region and followed high stimulation rates. Wave VI did not show intracortical polarity inversion nor was it abolished by epicortical or intracortical GABA administration. The data are compatible with a wave VI source in the terminal axons of the thalamo-cortical radiations. Middle latency auditory responses (MAEPs) generated 10-40 msec after auditory stimulation were also recorded in a circumscribed area of AI. In contrast to wave VI, these primary auditory cortex potentials (Pa 18.3 msec; Nb 31.9 msec) underwent transcortical polarity inversion, correlated with intracortical multi-unit activity in the AI region and were reversibly altered or abolished by epicortical or intracortical GABA administration to the AI region. The data suggest that the Pa and Nb components of the cat MAEP are intracortically generated by neuronal elements in the AI region.
Department of Neurology, University of California, Davis, VA Medical Center, Martinez, CA 94553.
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Knight
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Brailowsky
D000161:Acoustic Stimulation; D000818:Animals; D001303:Auditory Cortex / Q000187:drug effects / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods; D002415:Cats; D004594:Electrophysiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008839:Microelectrodes; D008845:Microinjections; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage
D005680:gamma-Aminobutyric Acid