A computer simulation of the natural history of HIV infection: insights and implications.
Computer simulation of the natural history of HIV infection shows that the progression from a silent infection to serious disease need not depend upon any particular biological event but only requires the passage of time. It likewise illustrates why modest efficacy from an antiretroviral agent can go a long way toward treating HIV infection, but a cure will be difficult to develop.
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Biomedical Sciences Division, Algorithms Incorporated, Northbridge, California 91325.
D015496:CD4-Positive T-Lymphocytes; D003198:Computer Simulation; D015658:HIV Infections / Q000097:blood / Q000209:etiology*; D006801:Humans; D007958:Leukocyte Count; D008954:Models, Biological; D016176:T-Lymphocyte Subsets; D013997:Time Factors