Abrogation of induced resistance to experimental allergic encephalomyelitis in guinea pigs by host-versus-graft reaction.
Experimental allergic encephalomyelitis (EAE) effector cells known to exist in guinea pigs with myelin basic protein-incomplete Freund's adjuvant (MBP-IFA)-induced resistance to EAE could be activated in vivo by means of allogeneic confrontation (local host-versus-graft reaction (HVGR)). The abrogation of the resistance was observed only when HVGR was combined with encephalitogenic challenge (myelin basic protein-complete Freund's adjuvant (MBP-CFA)) in a certain order and at certain time intervals. The injection of 20 x 10(7) gamma-irradiated allogeneic lymphoid cells 7 or 4 days prior to or along with MBP-CFA treatment resulted in development of EAE with delayed onset and protracted course. The effect was most prominent when HVGR was induced on day -4. Histological examination revealed inflammatory lymphoid cell infiltrations in spinal cord. Serum level of total and anaphylactic anti-MBP antibodies correlated with the clinical picture.
Institute of Cell Biology and Morphology, Sofia, Bulgaria.
M
M
Kozovska
M
M
Staykova
I
I
Goranov
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D005620:Freund's Adjuvant; D006168:Guinea Pigs; D006789:Host vs Graft Reaction; D007113:Immunity, Innate; D007519:Isoantigens / Q000276:immunology; D008214:Lymphocytes / Q000473:pathology; D004676:Myelin Basic Protein / Q000276:immunology
D001323:Autoantibodies; D007519:Isoantigens; D004676:Myelin Basic Protein; D005620:Freund's Adjuvant