[Hemopoiesis regulation in healthy subjects and in patients with aplastic anemia at high altitudes].
The paper deals with effects of high-altitude (3200 m) adaptation on the clinical presentation, hemopoiesis, proliferation and differentiation of erythroid bone-marrow cells, growth of cultured bone-marrow fibroblasts, iron metabolism, function of the adrenal cortex and T lymphocytes of aplastic anemia patients. The high-altitude adaptation improves the clinical picture, facilitates hemopoiesis and proliferation and maturation of erythroid bone marrow cells, increases the efficacy of the colony-formation of bone marrow cells, intensifies the glucocorticoid function of the adrenal cortex, and produces positive immunological changes in the organism. Repeated courses of mountain-climatic therapy produce a more stable clinicohematological remission and increase the survival and working capacity of patients. Indications of mountain-climatic therapy are presented.
Mirrakhimov
M M
MM
Raimzhanov
A R
AR
D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D000531:Altitude; D000741:Anemia, Aplastic / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D002980:Climate; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006410:Hematopoiesis; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged
D005319:Fetal Hemoglobin; D006854:Hydrocortisone
Reguliatsiia gemopoéza u zdorovykh liudeĭ i u bol'nykh aplasticheskoĭ anemieĭ v usloviiakh vysokogor'ia.