Influence of the concentration of metipranolol eye drops on the drug concentration in human aqueous humour.
The concentration of the metabolite of the beta-blocker metipranolol was determined in the aqueous humour of 89 cataract patients. At 1, 2 or 5 h before surgery, they received one drop (30 microliters) of a 0.1% or 0.3% solution of the drug. At 1, 2 or 5 h after the application of 0.1% metipranolol eye drops, desacetyl-metipranolol concentrations of 624.55, 235.29 and 88.02 ng/ml, respectively, were measured. At the same intervals after the instillation of 0.3% metipranolol eye drops, the respective values of 1289.20, 1120.88 and 327.36 ng/ml were found. The metabolite concentration in the eye drops and the values measured show no consistent correlation.
Schlosspark-Klinik, Augenabteilung, Berlin, Federal Republic of Germany.
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C
Kessler
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Bleckmann
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Kleintges
D000319:Adrenergic beta-Antagonists / Q000032:analysis; D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D003315:Cornea / Q000187:drug effects; D004304:Dosage Forms; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D014290:Metipranolol / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000032:analysis / Q000493:pharmacokinetics*; D008875:Middle Aged; D009883:Ophthalmic Solutions; D013999:Timolol / Q000493:pharmacokinetics
D000319:Adrenergic beta-Antagonists; D004304:Dosage Forms; D009883:Ophthalmic Solutions; C006204:deacetyltrimepranol; D013999:Timolol; D014290:Metipranolol