[Lymphocyte transformation responses to mitogens and specific antigens in patients with multiple sclerosis].
64 multiple sclerosis patients were studied for lymphocyte transformation responses to PHA, CON A, PWM and BMP. Some immunological parameter of multiple sclerosis patients, of patients with other neurological diseases and of healthy volunteers were compared. Mitogens (PHA, ConA and PWM) responsiveness of the peripheral blood mononuclear cells was significantly (P less than 0.05) diminished in multiple sclerosis patients compared to that of the blood donors. On the contrary MBP responsiveness was significantly increased after MBP exposure for 5 d. and 7 d. It was considered that the increased responsiveness was due to increased spontaneous proliferation.
Laboratory of Immunology, Tongji Medical University, Wuhan.
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Shen
D000328:Adult; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009103:Multiple Sclerosis / Q000276:immunology*; D004676:Myelin Basic Protein
D008934:Mitogens; D004676:Myelin Basic Protein