Hydroxyapatite cement based drug delivery systems: drug release in vitro.
A novel approach using a self-setting hydroxyapatite (HAP) cement as a skeletal drug delivery system has been proposed to solve the problem of delivering drugs to skeletal tissue at high local concentrations for desirable therapeutic effects. Hydroxyapatite cements loaded with antibiotics can be formed in situ and can be used as bonding materials between bone and prostheses as well as for drug release devices. The cement also possesses sufficient mechanical strength to be a potential bone grafting material. Using cephalexin and norfloxacin as model drugs, the continuous in vitro release profiles of these compounds from 0.9-4.8% by weight loaded cement pellets were observed. These drug release patterns correlated well with the Higuchi model. This hydroxyapatite cement drug delivery system can be applied in the treatment of osteomyelitis and infected compound fractures.
Yu
D
D
Department of Pharmaceutics, University of Utah, Salt Lake City 84112.
Tsai
C L
CL
Wong
J
J
Fox
J L
JL
D001843:Bone Cements; D002506:Cephalexin / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D005597:Fractures, Open / Q000188:drug therapy*; D006882:Hydroxyapatites / Q000008:administration & dosage*; D066298:In Vitro Techniques; D009643:Norfloxacin / Q000008:administration & dosage*; D010019:Osteomyelitis / Q000517:prevention & control*; D014677:Pharmaceutical Vehicles
D001843:Bone Cements; D003692:Delayed-Action Preparations; D006882:Hydroxyapatites; D014677:Pharmaceutical Vehicles; D009643:Norfloxacin; D002506:Cephalexin