Effect of FK-506 and cyclosporine on human T and B lymphoproliferative responses.
The macrolide antibiotic FK-506 causes a strong inhibition of human T and B cell proliferation in vitro in concentrations 100-fold lower than cyclosporine (CsA). However, B cell activation appears to be less sensitive to the immunosuppressive action of FK-506 than T cell responses. There was no indication of a synergistic interaction of the two agents. In contrast, CsA added together with FK could counteract the immunosuppressive activity of the latter drug.
Wasik
M
M
Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
Stepień-Sopniewska
B
B
Lagodziński
Z
Z
Górski
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D016559:Tacrolimus
D000900:Anti-Bacterial Agents; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D016559:Tacrolimus