Histamine release by platelet aggregation.
Coincubation of rat serosal mast cells with human platelets leads to a significant release of histamine. which dose-dependently increases when platelet aggregation is induced by various concentrations of arachidonic acid. In turn, histamine enhances platelet aggregation induced by different agonists, this effect being mimicked by pyridyl-ethyl-amine (PEA), blocked by mepyramine and amplified by ranitidine. The data suggest the existence of a platelet-derived histamine releasing factor (PDHRF) and indicate the presence of platelet H1 and H2 receptors, capable of modulating platelet aggregation.
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
P F
PF
Mannaioni
B
B
Palmerani
A
A
Pistelli
F
F
Gambassi
E
E
Giannella
T
T
Bani Sacchi
E
E
Masini
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000201:enzymology / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects*; D011725:Pyridines / Q000494:pharmacology; D011738:Pyrilamine / Q000494:pharmacology; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D011725:Pyridines; D011899:Ranitidine; C006183:2-(2-aminoethyl)pyridine; D007770:L-Lactate Dehydrogenase; D011738:Pyrilamine