[Effects of SP1-11 and its N-terminal fragment SP1-4 on several indices of the microcirculatory system in stress].
In the experiments on rats it was shown that 5-hour immobilization induced the disturbances of terminal blood flow, degranulation of mast cells, increase of venular permeability and contractile activity of lymphaticus. I/p injection SP1-11 (125 micrograms/kg) before stress aggravated the disturbances caused by immobilization. The prophylactic i/p injection SP1-4 induced tranquilizing (100%), sedative (30%) or narcosis (20%) effect. In the rats with sedative or narcosis effects the relative normalization of components of microcirculatory system was observed.
Gorizontova
M P
MP
Institute of General Pathology and Pathological Physiology USSR AMS, Moscow.
Speranskaia
T V
TV
Oeme
P
P
Odariuk
Iu
Iu
D000818:Animals; D002199:Capillary Permeability; D007103:Immobilization; D008297:Male; D008407:Mast Cells / Q000502:physiology; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors; D014699:Venules / Q000503:physiopathology
D013373:Substance P
Izuchenie deĭstviia SP1-11 i ego N-kontsevogo fragmenta SP1-4 na nekotorye pokazateli sistemi mikrotsirkuliatsii pri stresse.