Renal denervation does not prevent hypertension in Lyon hypertensive rats.
The effects on blood pressure (BP) of a single and repeated renal denervations (RD) were compared in genetically hypertensive (LH) and normotensive (LN) rats of the Lyon strain. Indirect BP was measured by the tail-cuff method, and direct BP was measured through an aortic catheter in conscious quiet rats receiving a normal-sodium diet. Single RD (10 wk of age) did not reduce BP in both LN and LH rats. Repeated RD (4, 7, and 10 wk of age) partly prevented the age-related increase in tail-cuff BP but did not affect the directly recorded BP in 11-wk-old LH rats. Single and repeated RD reduced the renal norepinephrine content by greater than 90%. Both procedures did not alter the BP lowering effects of angiotensin-converting enzyme inhibition and of ganglionic blockade. It is concluded that renal nerves are not necessary for the development and the maintenance of hypertension in LH rats.
Département de Physiologie, Centre National de la Recherche Scientifique, Faculté de Pharmacie, Lyon, France.
E H
EH
Boussairi
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C
Julien
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M
Ducher
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C
Barres
M
M
Vincent
J
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Sassard
D000818:Animals; D001794:Blood Pressure; D003714:Denervation; D005730:Ganglionic Blockers / Q000494:pharmacology; D006339:Heart Rate; D006973:Hypertension / Q000378:metabolism* / Q000517:prevention & control; D007668:Kidney / Q000294:innervation* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains
D005730:Ganglionic Blockers; D009638:Norepinephrine