Multiple bullae and paresis after drug-induced coma.
Two cases of bullous skin lesions and paresis following coma due to the ingestion of many antipsychotic drugs were reported. Histological examination showed an intra-epidermal blister in case 1 and degeneration of sweat glands in both cases. An immunofluorescence study showed massive deposits of IgM and C3 in the dermal vessels. As similar deposits of immunoglobulin and complement were not observed in patients with ordinary lesions such as decubitus, a different mechanism in the formation of the bullous skin lesion other than pressure is suggested.
Department of Dermatology, Mie University School of Medicine, Tsu, Japan.
Y
Y
Taniguchi
Y
Y
Wada
M
M
Takahashi
M
M
Harada
M
M
Shimizu
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001706:Biopsy; D003128:Coma / Q000139:chemically induced*; D003176:Complement C3 / Q000032:analysis; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D010243:Paralysis / Q000139:chemically induced*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
D014150:Antipsychotic Agents; D003176:Complement C3; D007075:Immunoglobulin M