[The comparative effectiveness of using basic preparations in the combined therapy of rheumatoid arthritis].
Comparison of the time-course of changes in the clinico-laboratory, x-ray and immunological findings in RA patients under the influence of the treatment with azathioprine (50 patients) sulfasalazine (42 patients) and their combination (48 patients) has demonstrated that the best effect (64.6%) may be provided by the use of combined therapy. Azathioprine and sulfasalazine should be administered in combination to patients with seropositive RA, systemic disease manifestations and a high laboratory activity as well as to patients with hormonal dependence. To reduce the number of untoward effects the indicated basic drugs should be applied in moderate doses.
Tsitlanadze
V G
VG
Shalamberidze
L P
LP
Dzidziguri
L M
LM
Kartvelishvili
E Iu
EIu
Shakulashvili
N A
NA
Gegeshidze
D G
DG
Astvatsaturova
T R
TR
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001379:Azathioprine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D012460:Sulfasalazine / Q000627:therapeutic use*; D013997:Time Factors
D012460:Sulfasalazine; D001379:Azathioprine
Sravnitel'naia éffektivnost' primeneniia nekotorykh bazisnykh preparatov v kompleksnoĭ terapii revmatoidnogo artrita.