Manganese superoxide dismutase: nucleotide and deduced amino acid sequence of a cDNA encoding a new human transcript.
Three human cDNA libraries were screened with a human manganese superoxide dismutase (Mn-SOD) cDNA under moderately stringent conditions to characterize a large 4-6 kb RNA species which hybridizes to Mn-SOD in RNA blot analyses. A new 4.2 kb Mn-SOD cDNA clone (Mn-SOD 1) was isolated. Its long 3426 nucleotide 3'-untranslated sequence contains both of the 240 base 3'-untranslated sequences of the 1 kb Mn-SOD 4 and 5 cDNAs. This is a fully processed, cytoplasmic RNA species and raises the possibility of a role for particular 3'-untranslated sequence selection in Mn-SOD gene regulation.
Department of Pediatrics, St. Louis Children's Hospital, Washington University School of Medicine, MO 63110.
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Church
D000595:Amino Acid Sequence; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D012313:RNA / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics*; D014158:Transcription, Genetic
D012313:RNA; D004247:DNA; D013482:Superoxide Dismutase