Effects of cetirizine on human eosinophil and neutrophil activation in vitro.
The ability of cetirizine, a novel antihistamine agent, to inhibit the in vivo activation of human eosinophils, neutrophils and monocytes has been investigated using C3b- and IgG-dependent rosette formation, cytotoxicity against opsonised parasitic larvae and adherence to plasma-coated glass (PCG). The drug inhibited platelet-activating factor (PAF)-induced enhancement of eosinophil and neutrophil IgG (Fc) and complement (C3b) rosettes with an IC50 of 2 x 10(-5) M. There was also comparable inhibition of PAF-dependent enhancement of eosinophil cytotoxicity (for complement-coated schistosomula of Schistosoma mansoni). Cetirizine inhibited PAF-induced eosinophil, but not neutrophil, hyperadherence to PCG. These data support the view that cetirizine may exert some of its anti-allergic effects by inhibiting the activation of human granulocytes and that it may also selectively inhibit PAF-induced eosinophil hyperadherence.
Department of Allergy and Clinical Immunology, National Heart and Lung Institute, London, UK.
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Walsh
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Moqbel
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Hartnell
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Kay
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D017332:Cetirizine; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000187:drug effects* / Q000276:immunology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006919:Hydroxyzine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007074:Immunoglobulin G; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D012397:Rosette Formation; D012550:Schistosoma mansoni / Q000276:immunology
D006634:Histamine H1 Antagonists; D007074:Immunoglobulin G; D010972:Platelet Activating Factor; D006919:Hydroxyzine; D003165:Complement System Proteins; D017332:Cetirizine