Cerebellar phenotype of two alleles of the 'reeler' mutation on similar backgrounds.
Using congenic strains, the two alleles ('Ed' and 'Orl') of the reeler mutation in mice have been compared on two genetic backgrounds (B6 and C). The phenotypic differences in cerebellar organization between the 4 homozygous reeler mutant strains appeared related to the genetic background rather than to allelic differences.
Department of Physiology, FNPD School of Medicine, Namur, Belgium.
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Goffinet
D000483:Alleles; D000818:Animals; D015139:Blotting, Southern; D002531:Cerebellum / Q000033:anatomy & histology*; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific; D006720:Homozygote; D051379:Mice; D008818:Mice, Neurologic Mutants; D009154:Mutation; D010641:Phenotype; D015183:Restriction Mapping
D004247:DNA; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific