Basophil releasability in human hydatidosis.
We studied immunoglobulin E (IgE)- and non-IgE-mediated releasability in basophils from 31 patients with hydatidosis. Histamine release to non-IgE-dependent stimuli did not differ significantly between normal individuals and patients with hydatidosis. On the contrary, an increased histamine liberation was obtained by challenging basophils from hydatid patients with anti-human IgE. It is concluded that Echinococcus granulosus infection induces an enhanced sensitivity of basophils to IgE-dependent stimuli.
Istituto di Clinica delle Malattie Tropicali e Infettive, Università La Sapienza, Roma, Italia.
A
A
Aceti
D
D
Celestino
M
M
Caferro
A
A
Teggi
A
A
Pennica
E
E
Adriani
A
A
Grilli
S
S
Paparo
O
O
Leri
F
F
De Rosa
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D000947:Antigens, Helminth / Q000276:immunology; D001491:Basophils / Q000276:immunology*; D004443:Echinococcosis / Q000276:immunology*; D004446:Echinococcus / Q000276:immunology; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology / Q000494:pharmacology
D000888:Antibodies, Anti-Idiotypic; D000947:Antigens, Helminth; C026408:anti-IgE antibodies; D007073:Immunoglobulin E