Assessment of residual curarization using low-current stimulation.
The present study employed train-of-four (TOF) stimulation at a current of 20 mA to assess the incidence and degree of residual neuromuscular blockade in 64 randomly selected Post Anesthesia Care Unit (PACU) patients. Group C (Control, n = 10) had received anaesthesia without nondepolarizing muscle relaxant; Group V (n = 25) had received vecuronium; and Group P (n = 29) had received pancuronium. At the end of surgery, each patient had been considered by his anaesthetist to have adequate neuromuscular function on the basis of clinical signs and tactile or visual evaluation of responses to TOF stimulation. However, upon testing in the PACU 15 min later, 45% (13 of 29) of Group P patients and 8% (2 of 25) of Group V patients had a TOF ration less than 0.70. This study indicates that residual curarization may be commonly encountered following long-acting relaxants despite qualitative intraoperative TOF monitoring. The present incidence, detected at a current of 20 mA, is consistent with previous reports which employed supramaximal TOF stimulation. We conclude that despite intraoperative monitoring, residual curarization following long-acting nondepolarizing agents is common and that it may be detected with TOF at a low stimulating current (20 mA).
Brull
S J
SJ
Department of Anesthesiology, Yale University School of Medicine, Yale-New Haven Hospital, New Haven, CT 06510.
Ehrenwerth
J
J
Connelly
N R
NR
Silverman
D G
DG
D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D004558:Electric Stimulation; D006801:Humans; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects / Q000502:physiology*; D010197:Pancuronium / Q000494:pharmacology*; D014673:Vecuronium Bromide / Q000494:pharmacology*
D014673:Vecuronium Bromide; D010197:Pancuronium