Aminopeptidases and angiotensin I-converting enzyme activities in primary human lung tumors and lung parenchyma.
The activities of alanyl aminopeptidase (AAP), arginyl aminopeptidase (RAP), alpha-glutamyl aminopeptidase (EAP) and angiotensin I-converting enzyme (ACE) were investigated in primary human lung tumors of different histological types and in matched lung parenchyma. In contrast to the studied aminopeptidases whose activity differences between tumor and lung tissues were infrequently significant, the activity of ACE was decreased highly significantly in the majority of lung tumors.
Research Institute of Tuberculosis and Respiratory Diseases, Prague, CSFR.
J
J
Procházka
E
E
Krepela
A
A
Sedo
J
J
Viklický
P
P
Fiala
D000230:Adenocarcinoma / Q000201:enzymology; D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000201:enzymology; D000328:Adult; D000368:Aged; D000626:Aminopeptidases / Q000096:biosynthesis*; D018826:CD13 Antigens; D018288:Carcinoma, Small Cell / Q000201:enzymology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology; D043384:Glutamyl Aminopeptidase; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008175:Lung Neoplasms / Q000201:enzymology*; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis*; D012509:Sarcoma / Q000201:enzymology
D000626:Aminopeptidases; D018826:CD13 Antigens; C019721:aminopeptidase B; D043384:Glutamyl Aminopeptidase; D007703:Peptidyl-Dipeptidase A