Shared antigenicity and immunogenicity of type 4 pilins expressed by Pseudomonas aeruginosa, Moraxella bovis, Neisseria gonorrhoaea, Dichelobacter nodosus, and Vibrio cholerae.
Immunoblotting with polyclonal rabbit antibodies raised against pilins expressed by Pseudomonas aeruginosa, Moraxella bovis, Neisseria gonorrhoeae, Dichelobacter nodosus, and Vibrio cholerae was used to demonstrate that these polypeptides display conserved antigenic and, in most cases, immunogenic determinants. These determinants appear to be localized to the highly homologous amino-terminal domains (residues 1 to 25).
Department of Epidemiology, University of Michigan, Ann Arbor 48109.
P
P
Patel
C F
CF
Marrs
J S
JS
Mattick
W W
WW
Ruehl
R K
RK
Taylor
M
M
Koomey
D000818:Animals; D001439:Bacteroides / Q000276:immunology*; D003429:Cross Reactions; D010861:Fimbriae, Bacterial / Q000276:immunology*; D007106:Immune Sera / Q000276:immunology; D015151:Immunoblotting; D016955:Moraxella bovis / Q000276:immunology*; D009344:Neisseria gonorrhoeae / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D011817:Rabbits; D014734:Vibrio cholerae / Q000276:immunology*
D007106:Immune Sera