Concentrations of essential elements after repeated administrations of tin and selenium.
To study effects of simultaneous administration of tin (Sn) and selenium (Se) on concentrations of several essential elements, mice were injected with either SnCl2 (ip) or Na2SeO3 (sc), alone or both compounds at a daily dose of 5 mumol/kg each for 12 consecutive days. Mice were sacrificed at 20 h after the last injection and concentrations of Sn, Se, Na, Ca, Zn, P, Fe, K, and Mg in the liver, kidney, spleen, pancreas, testis, seminal vesicle, lung, femoral muscle, and femoral bone were determined. In the control mice, Sn and Se concentrations were the highest in bone (0.69 micrograms Sn and 6.93 micrograms Se/g dry wt). Administered Sn was found to accumulate in all organs except the testis. Among the essential elements determined, Na was the most affected in terms of concentration in the organs and Mg was the least affected element in these organs. Among the organs tested, each elemental concentration in the pancreas was most affected. Simultaneous injections of Sn and Se appeared to keep the correlation coefficients between elements similar to those found in the control mice.
Department of Hygiene, Juntendo University School of Medicine, Tokyo, Japan.
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M
Chiba
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M
Kikuchi
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C
Tohyama
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Nishikawa
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004334:Drug Administration Schedule; D005260:Female; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010758:Phosphorus / Q000378:metabolism; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D012964:Sodium / Q000378:metabolism; D014001:Tin / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D014018:Tissue Distribution; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D014131:Trace Elements; D010758:Phosphorus; D014001:Tin; D012964:Sodium; D007501:Iron; D012643:Selenium; D008274:Magnesium; D015032:Zinc; D002118:Calcium