Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes.
Dual exposure to Epstein-Barr virus and purified 4-deoxyphorbol ester derived from the plant Euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human B lymphocytes in vitro. Rearrangements most commonly affected chromosome 8, the chromosome most often showing structural changes in Burkitt's lymphoma (BL) cells. E tirucalli is indigenous in parts of Africa where BL is endemic and may be an important risk factor for the disease.
Department of Virology, Hokkaido University School of Medicine, Sapporo, Japan.
T
T
Aya
T
T
Kinoshita
S
S
Imai
S
S
Koizumi
F
F
Mizuno
T
T
Osato
C
C
Satoh
T
T
Oikawa
N
N
Kuzumaki
H
H
Ohigashi
D001402:B-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000382:microbiology; D002898:Chromosomes, Human, Pair 8 / Q000187:drug effects; D004781:Environmental Exposure; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D010703:Phorbol Esters / Q000494:pharmacology; D010946:Plants, Medicinal; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D014178:Translocation, Genetic
D010703:Phorbol Esters; D016271:Proto-Oncogene Proteins c-myc