Improving CD4+ lymphocyte counts in HIV-infected hemophilia patients. A favorable prognostic indicator?
CD4+ lymphocyte counts of 91 HIV+ hemophilia patients were monitored for a mean of 4 years (range: 15-69 months). CD4+ lymphocytes decreased in 55 but increased in 36 patients over time. The CD4+ cell increases were persistent in 5 patients, whereas they fluctuated in 31. Of the 36 patients with increasing CD4+ counts 3 developed AIDS and 1 LAS. The other 32 patients were clinically asymptomatic (CDC II), but had immunological abnormalities, such as increased serum neopterin (N = 18) and impaired in vitro T cell responses to pooled allogenic stimulator cells (N = 15) or mitogens (N = 18). In contrast, of the 55 patients whose CD4+ cells decreased, 24 developed AIDS and 5 ARC (P less than 0.0005). Only 2 of these 55 patients had normal mitogen stimulation in vitro and normal serum neopterin levels.
Department of Transplantation Immunology, University of Heidelberg, F.R.G.
V
V
Daniel
R
R
Weimer
R
R
Zimmermann
A
A
Huth-Kühne
J
J
Weisser
E
E
Braun
G
G
Opelz
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000911:Antibodies, Monoclonal; D001323:Autoantibodies / Q000276:immunology; D001708:Biopterins / Q000031:analogs & derivatives / Q000097:blood; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes; D005434:Flow Cytometry; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D006679:HIV Seropositivity / Q000097:blood / Q000276:immunology; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology; D019798:Neopterin; D011379:Prognosis
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001708:Biopterins; D019798:Neopterin