[The participation of humoral factors released by the endothelium in the development of reactive hyperemia].
In anesthetized dogs and on test-preparations of isolated vascular rings of femoral artery used for detection of appearance of vasoactive substances in venous blood, the reactive hyperemia was accompanied by the appearance of vasodilation substances in blood, the concentration of which increased with the occlusion duration. Chemical injury of endothelium by saponin, inhibition of lipoxygenase by quercetin and guanylate cyclase by methylene blue decreased the reactive hyperemia and the relaxation of test-preparation. Cyclooxygenase inhibition by indomethacin did not affect the reactive hyperemia or release of vasoactive substances. The endothelium seems to play an important role in development of reactive hyperemia induced by endothelium-derived relaxing factor release.
V F
VF
Sagach
M N
MN
Tkachenko
T N
TN
Kovalenko
D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors; D004285:Dogs; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology; D005268:Femoral Vein / Q000187:drug effects / Q000502:physiology; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors; D006940:Hyperemia / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism*; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D018377:Neurotransmitter Agents; D016718:Arachidonic Acid; D006162:Guanylate Cyclase
Uchastie gumoral'nykh faktorov, vydeliaemykh éndoteliem, v razvitii reaktivnoĭ giperemii.