Chlorpyrifos toxicosis in two cats.
Organophosphate compounds are widely employed for control of external parasites in cats and for control of insects in homes and yards. Chlorpyrifos is a long-acting organophosphate (OP) available for use as a systemically and topically acting parasiticide and insecticide in cattle. Its use on cats is not recommended, and no previous clinical cases of toxicosis have been described. Two cases of chronic chlorpyrifos toxicosis in cats are presented and pathophysiology as well as treatment are discussed. The cats had been showing signs of chronic organophosphate toxicosis before diazepam administration. Signs of acute organophosphate toxicosis were precipitated after diazepam was given. Treatment with pralidoxime chloride (2-PAM) and atropine was attempted. Response to treatment was dramatic and complete recovery was achieved with six injections of pralidoxime and atropine administration.
Jaggy
A
A
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602.
Oliver
J E
JE
D000818:Animals; D001285:Atropine / Q000627:therapeutic use; D002371:Cat Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D004390:Chlorpyrifos / Q000506:poisoning*; D002802:Cholinesterases / Q000097:blood; D002908:Chronic Disease; D003402:Creatine Kinase / Q000097:blood; D003975:Diazepam / Q000009:adverse effects*; D004357:Drug Synergism; D004576:Electromyography / Q000662:veterinary; D005260:Female; D008297:Male; D011220:Pralidoxime Compounds / Q000627:therapeutic use
D011220:Pralidoxime Compounds; D001285:Atropine; D003402:Creatine Kinase; D002802:Cholinesterases; D004390:Chlorpyrifos; D003975:Diazepam