A new mouse T-cell receptor alpha chain variable region family.
Sequence analysis of the rearranged T-cell receptor alpha chain gene segments from an influenza reactive T-cell clone T2.5-5 and a hemin chloride reactive T-cell hybrid SJL-HE-1.1 have revealed a previously undescribed V alpha gene family. We have designated this family V alpha 15. Southern hybridization analysis has indicated that this family most probably contains only two members, and that these are conserved in each of six mouse strains representing three previously described V alpha haplotypes: V alpha a, V alpha b, and V alpha c.
Department of Microbiology, University of Pennsylvania, Philadelphia 19104.
R M
RM
Sutherland
Y
Y
Paterson
P A
PA
Scherle
W
W
Gerhard
A J
AJ
Caton
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002460:Cell Line; D015342:DNA Probes; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
D015342:DNA Probes; D016693:Receptors, Antigen, T-Cell, alpha-beta