[Epidemic keratoconjunctivitis: treatment results during an epidemic].
150 patients with adenovirus type 8 infection where treated at random, in a prospective study. Based upon a quantifiable conjunctivitis severity score we tried to find out where there are differences in treatment. The best results were seen using polyvinylpyrrolidone-iodine (Betaisodona) although it could not prevent totally subepithelial corneal infiltrates. The combination of exogenous interferon alpha with polyvinylpyrrolidone-iodo-drops or trifluorothymidine-drops was less successful. We could not show any prophylactic effect of interferon on uninflamed fellow eyes. Treatment with vasoconstrictor did not show any therapeutic or prophylactic potency. This group of patients must be seen as a control group and the results of effective therapy should significantly differ from the results in this group. Topical corticosteroids should be reserved for severe symptomatic cases and those with iritis and pseudomembranous conjunctivitis. Giving topical corticosteroids in combination with antibiotics we did not find any influence on the incidence of subepithelial keratitis or the number of corneal infiltrates. The mean duration of acute keratoconjunctivitis using this therapy was longer than the mean duration in the control group with vasoconstrictor.
Universitäts-Augenklinik Ulm.
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Hutter
D000180:Acrylic Resins / Q000008:administration & dosage; D000258:Adenovirus Infections, Human / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage; D004196:Disease Outbreaks; D004359:Drug Therapy, Combination; D015828:Eye Infections, Viral / Q000188:drug therapy*; D005839:Gentamicins / Q000008:administration & dosage; D006801:Humans; D007372:Interferons / Q000008:administration & dosage; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010109:Oxymetazoline / Q000008:administration & dosage; D011206:Povidone-Iodine / Q000008:administration & dosage; D011446:Prospective Studies; D014271:Trifluridine / Q000008:administration & dosage
D000180:Acrylic Resins; D005839:Gentamicins; D009883:Ophthalmic Solutions; C006903:carbopol 940; D003907:Dexamethasone; D011206:Povidone-Iodine; D010109:Oxymetazoline; D007372:Interferons; D014271:Trifluridine
Keratokonjunktivitis epidemica: Therapieergebnisse während einer Epidemie.