Tissue monoamine and plasma corticosterone concentrations following sympathetic alteration during acute endotoxicosis in chickens.
1. Splenic and heart ventricular NE levels and plasma corticosterone concentrations were increased following E. coli endotoxin administration in three-week-old chicks. 2. Chicks receiving either reserpine or propranolol injection before endotoxin exhibited increased NE in both tissues while only splenic 5-HT increased in birds receiving propranolol and endotoxin. 3. The effects of acute bacterial infection in chickens involves the peripheral nervous system neurotransmitters, NE and 5-HT, in the regulation of immune response.
North Carolina State University, Department of Poultry Science, Raleigh 27695-7635.
H M
HM
Brown-Borg
F W
FW
Edens
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D002645:Chickens; D003345:Corticosterone / Q000097:blood*; D004731:Endotoxins / Q000506:poisoning*; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013154:Spleen / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects; D013997:Time Factors
D015306:Biogenic Monoamines; D004731:Endotoxins; D012701:Serotonin; D012110:Reserpine; D011433:Propranolol; D003345:Corticosterone; D009638:Norepinephrine