FLFQPQRF-amide modulates alpha 2-adrenergic antinociception in the rat dorsal horn in vivo.
The interaction between FLFQPQRFamide and alpha 2-adrenergic spinal antinociception was examined in an electrophysiological study in the intact anaesthetised rat. The inhibition of C fibre-evoked neuronal responses by the selective alpha 2-adrenergic agonist dexmedetomidine was significantly reduced by intrathecal FLFQPQRFamide pretreatment. The results suggest a modulatory role of FLFQPQRFamide in spinal alpha 2-adrenergic antinociception.
Department of Pharmacology, University College London, U.K.
A F
AF
Sullivan
E A
EA
Kalso
H J
HJ
McQuay
A H
AH
Dickenson
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D007093:Imidazoles / Q000494:pharmacology*; D020926:Medetomidine; D008969:Molecular Sequence Data; D009412:Nerve Fibers / Q000187:drug effects; D009842:Oligopeptides / Q000502:physiology*; D051381:Rats
D000316:Adrenergic alpha-Agonists; D000700:Analgesics; D007093:Imidazoles; D009842:Oligopeptides; C053651:phenylalanyl-leucyl-phenylalanyl-glutaminyl-prolyl-glutaminyl-arginyl-phenylalaninamide; D020926:Medetomidine