[Antisecretory drugs, hypergastrinemia and hyperplasia of enterochromaffin-like cells (ECL)].
A review of the literature was carried out in order to identify those mechanisms responsible for hyperplasia of Enterochromaffin-like cells (ECL) undergoing treatment with antisecretory drugs. All gastric acid secretion-inhibiting drugs cause a physiological increase in gastrinemia due to their inhibitory function. ECL hyperplasia is the consequence of the duration of hypergastrinemia. To date no factors responsible for the possible transformation of hyperplasia into carcinoma have yet been identified.
Divisione di Gastroenterologia, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia.
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A
Andriulli
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A
Mangia
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F
Lawson
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002276:Carcinoid Tumor / Q000209:etiology; D004759:Enterochromaffin Cells / Q000187:drug effects / Q000473:pathology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D005757:Gastritis, Atrophic / Q000209:etiology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006801:Humans; D006965:Hyperplasia; D008297:Male; D009853:Omeprazole / Q000494:pharmacology; D051381:Rats; D013274:Stomach Neoplasms / Q000209:etiology; D015043:Zollinger-Ellison Syndrome / Q000209:etiology
D000897:Anti-Ulcer Agents; D005755:Gastrins; D006635:Histamine H2 Antagonists; D009853:Omeprazole
Farmaci antisecretivi, ipergastrinemia ed iperplasia delle ECL.