Recent advances in catalytic antibodies.
Recently the biological machinery of the immune system has been exploited with the aid of mechanistic chemistry to produce catalytic antibodies. Because antibodies can be generated that selectively bind almost any molecule of interest, this new technology offers the potential to tailor-make highly selective catalysts for applications in biology, chemistry and medicine. In addition, catalytic antibodies provide fundamental insight into important aspects of biological catalysis, including the importance of transition-state stabilization, proximity effects, general acid and base catalysts, electrophilic and nucleophilic catalysis, and strain.
Scanlon
T S
TS
Department of Chemistry, University of California, Berkeley 94720.
Schultz
P G
PG
D000906:Antibodies / Q000378:metabolism; D001666:Binding Sites, Antibody; D002384:Catalysis; D003067:Coenzymes / Q000378:metabolism; D007700:Kinetics; D011485:Protein Binding; D013816:Thermodynamics
D000906:Antibodies; D003067:Coenzymes