Effect of intranigral Mn2+ on striatal and nigral synthesis and levels of dopamine and cofactor.
A single injection of manganese chloride into the rat substantia nigra caused a significant and reversible drop in nigral and striatal dopamine and cofactor content ipsilateral to the lesion. Maximal decrease, in both tissues, was observed 60 days after the lesion, and showed complete recovery at 90 days. In vivo striatal tyrosine hydroxylation and GTP cyclohydrolase activities were also decreased maximally at 60 days and were recovered by 90 days after the lesion. No effects were observed on the side contralateral to the injection.
Daniels
A J
AJ
Division of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, NC 27709.
Abarca
J
J
D000818:Animals; D001708:Biopterins / Q000378:metabolism*; D002712:Chlorides; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D004298:Dopamine / Q000096:biosynthesis / Q000378:metabolism*; D007839:Functional Laterality; D006136:GTP Cyclohydrolase / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000008:administration & dosage; D017895:Manganese Compounds; D020149:Manganese Poisoning; D009498:Neurotoxins / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013238:Stereotaxic Techniques; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002712:Chlorides; D017895:Manganese Compounds; D009498:Neurotoxins; D001708:Biopterins; D008345:Manganese; D014446:Tyrosine 3-Monooxygenase; D006136:GTP Cyclohydrolase; C025340:manganese chloride; D004298:Dopamine