Can .OH scavengers protect against direct UV-C damage in vivo?
It has previously been shown that ethanol and tert-butanol protect poly(U) against strand breaks from pulsed laser ultraviolet (UV) photons (lambda = 248 nm). This protection is believed to be based on a modification of direct DNA damage, not on scavenging hydroxyl radicals. In this paper, several .OH scavengers were tested in vivo with Escherichia coli DNA repair-deficient mutants to see if protection could also be demonstrated with non-laser UV photons (lambda approximately 254 nm). No protection was observed.
Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA 19102.
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D000440:Butanols / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects*; D000431:Ethanol / Q000494:pharmacology; D016166:Free Radical Scavengers; D005990:Glycerol / Q000494:pharmacology; D006878:Hydroxides; D017665:Hydroxyl Radical; D000432:Methanol / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014466:Ultraviolet Rays; D020002:tert-Butyl Alcohol
D000440:Butanols; D016166:Free Radical Scavengers; D006878:Hydroxides; D011837:Radiation-Protective Agents; D017665:Hydroxyl Radical; D000431:Ethanol; D020002:tert-Butyl Alcohol; D005990:Glycerol; D000432:Methanol; D004121:Dimethyl Sulfoxide