Lack of cosegregation of the subgroup II antigens on genes 2 and 6 in porcine rotaviruses.
The rotavirus subgroup I and II specificities associated with gene 2 and 6 products (vp2 and vp6, respectively) were shown not to cosegregate in a number of porcine rotavirus strains. The porcine OSU rotavirus strain and OSU-vp7-like strains were all found to possess a subgroup II-specific region on vp2 and a subgroup I-specific region on vp6. Of interest is the observation that the subgroup II-specific epitope on vp2 appears to be present only in human and porcine rotavirus strains, suggesting a possible human-pig ancestral lineage for gene 2.
Department of Medicine and Medical Microbiology, Stanford University School of Medicine, California 94305.
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L
Svensson
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Padilla-Noriega
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K
Taniguchi
H B
HB
Greenberg
D000818:Animals; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D002213:Capsid / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D036022:Capsid Proteins; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000032:analysis; D005455:Fluorescent Antibody Technique; D005814:Genes, Viral; D006801:Humans; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D013552:Swine; D015678:Viral Structural Proteins / Q000235:genetics*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D036022:Capsid Proteins; D000939:Epitopes; C442545:VP2 protein, Rotavirus; D015678:Viral Structural Proteins