Mechanisms of immunosuppression by FK506. Preservation of T cell transmembrane signal transduction.
Bierer
B E
BE
Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
Schreiber
S L
SL
Burakoff
S J
SJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003524:Cyclosporins / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007376:Interleukin-2 / Q000096:biosynthesis; D007938:Leukemia / Q000378:metabolism / Q000503:physiopathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D016559:Tacrolimus; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D003524:Cyclosporins; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D016559:Tacrolimus