[The effect amniocen preparation on nucleic acid metabolism in rat liver cells].
Rates of DNA and RNA synthesis as well as transport of RNA into cytoplasmic structures of rat liver cells were studied after administration of amniocen preparation. The drug did not affect the rate of DNA and RNA synthesis in intact rat liver cells, while specific radioactivity of DNA was decreased in regenerating liver tissue 24 hrs after hepatectomy. Amniocen inhibited the rate of rRNA, mRNA and tRNA transport into cytoplasm but contributed to elevated penetration of nucleic acid precursors into rat liver cells. Effect of the drug on cell membrane system appears to be responsible for its biological action related to realization of genetic information.
A I
AI
Bozhkov
V G
VG
Gopkalov
A I
AI
Skliar
Ts M
TsM
Shereshevskaia
M K
MK
Asadova
D000650:Amnion; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects; D012313:RNA / Q000096:biosynthesis* / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts; D012313:RNA; D004247:DNA
Vliianie preparata amniotsena na metabolizm nukleinovykh kislot v kletkakh pecheni krys.