Clinical studies of granulocyte colony stimulating factor (G-CSF).
Granulocyte colony stimulating factor (G-CSF) can safely stimulate the production of neutrophils in normal and neutropenic patients. Phase II studies have shown potential benefit when G-CSF is given after chemotherapy and bone marrow transplantation and in dose intensification studies. Studies in myelodysplasia, chronic neutropenia and AIDS all show great promise. Phase III studies are now in progress, which will help identify precisely the role of this exciting molecule.
Cancer Research Campaign Department of Medical Oncology, Christie Hospital, Withington, Manchester.
J H
JH
Scarffe
A
A
Kamthan
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D016026:Bone Marrow Transplantation; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D016179:Granulocyte Colony-Stimulating Factor / Q000493:pharmacokinetics / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D009436:Neural Tube Defects / Q000188:drug therapy; D009503:Neutropenia / Q000188:drug therapy
D016179:Granulocyte Colony-Stimulating Factor