Stretch-activated cation channels with large unitary conductance in leech central neurons.
Stretch-activated cation channels were identified in the soma membrane of leech central neurons. These channels were almost silent under normal experimental conditions and were distinctly activated by application of negative pressure to the patch pipette. The channels exhibited a preferential selectivity for K+ and a slope conductance of about 200 pS, in symmetrical K+ solution. In cell-attached patches these cation channels were activated by cell swelling.
Dipartimento di Fisiologia e Biochimica Universitá di Pisa, Italy.
M
M
Pellegrino
M
M
Pellegrini
A
A
Simoni
C
C
Gargini
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D007038:Hypotonic Solutions; D007473:Ion Channels / Q000502:physiology*; D007865:Leeches; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D011312:Pressure; D012964:Sodium / Q000494:pharmacology
D007038:Hypotonic Solutions; D007473:Ion Channels; D012964:Sodium; D011188:Potassium