Effects of gastrointestinal peptides on formation of gallstone in guinea pigs.
In light of the effects of gastrointestinal (GI) peptides on bile secretion and biliary tract mobility, we studied the effects of GI peptides on gallstone formation in guinea pigs fed on low protein lithogenic diet. The peptides under study included cholecystokinin octapeptide (CCK-8), vasoactive intestinal peptide (VIP), somatostatin (SRIF), secretin (SEC), and neurotensin (NT). Hepatic bile flow, electrolytes, and other bile components were also measured. It was found that CCK-8 and VIP suppressed the formation of gallstones and increased hepatic bile flow and Na+, K+, Cl- output significantly. On the other hand, SRIF significantly promoted gallstone formation. The rates of gallstone formation in CCK-8, VIP, and SRIF treated guinea pigs were 15.4%, 23.5%, and 88.0%, respectively, in contrast to 56.8% in the control group. The inhibitory effect of CCK-8 and promoting effect of SRIF on gallstone formation were dose-dependent.
Division of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Bejing.
Y F
YF
Chen
Y J
YJ
Chen
B A
BA
Deng
G N
GN
Sun
G J
GJ
Lu
G Z
GZ
Pan
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D002769:Cholelithiasis / Q000209:etiology* / Q000378:metabolism; D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D009496:Neurotensin / Q000494:pharmacology; D012844:Sincalide / Q000494:pharmacology; D013004:Somatostatin / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D009496:Neurotensin; D013004:Somatostatin; D012844:Sincalide