Cytochrome P-450 mediated metabolism of progesterone by adrenal microsomes of PCB-treated and untreated barn owl (Tyto alba) and marsh turtle (Mauremys caspica) in comparison with the guinea-pig.
1. Significant differences between species were observed in the profile of steroids produced from progesterone by adrenal microsomes as well as in the effects elicited by Aroclor 1254 on cytochrome P-450-mediated activities. 2. In the guinea-pig, the major metabolites were products of the corticosteroid pathway but products of the androgenic pathway were also detected; in the barn owl products of both pathways were also formed while in the marsh turtle only products of the corticosteroid pathway were detected. 3. The effect of Aroclor 1254 on P-450C21 activity in the turtle and barn owl was inductive in contrast to the inhibitory effect observed in the guinea-pig.
Institute for Nature Conservation Research, George S. Wise Faculty for Life Sciences, Tel Aviv University, Ramat Aviv, Israel.
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D
Goldman
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Yawetz
D019326:17-alpha-Hydroxyprogesterone; D000311:Adrenal Glands / Q000648:ultrastructure*; D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D001717:Birds / Q000378:metabolism*; D020111:Chlorodiphenyl (54% Chlorine); D003350:Cortodoxone / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000378:metabolism; D006168:Guinea Pigs; D006908:Hydroxyprogesterones / Q000378:metabolism; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism*; D013053:Spectrophotometry; D014426:Turtles / Q000378:metabolism*
D001140:Aroclors; D006908:Hydroxyprogesterones; D020111:Chlorodiphenyl (54% Chlorine); D003900:Desoxycorticosterone; D011374:Progesterone; D019326:17-alpha-Hydroxyprogesterone; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls; D003350:Cortodoxone