Regional chemotherapy of inoperable maxillofacial tumours combined with radiotherapy. Long-term results.
At the Department of Oral Maxillo-Facial Surgery, University of Vienna, we have from January 1973 to September 1985, subjected 117 patients with inoperable malignant tumours in the maxillo-facial area to intra-arterial chemotherapy consisting of methotrexate and bleomycin. In this group 103 patients have also been given radiotherapy. In this report only 68 patients of the group of 103 patients who have undergone combined treatment have been considered eligible for evaluation on the basis of their post-therapeutic survival time, which ranged from 2 to 11 years. 10 cases with complete remission and 34 cases with partial remission were observed, indicating that 65% responded to combined treatment.
Dept. of Oral and Maxillo-Facial Surgery, University of Vienna, Austria.
K
K
Hollmann
G
G
Mailath
M
M
Rasse
J
J
Kühlböck
B
B
Stadler
D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D007261:Infusions, Intra-Arterial; D007573:Jaw Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy; D012074:Remission Induction; D015996:Survival Rate
D001761:Bleomycin; D008727:Methotrexate