Insertions in the prion protein gene in atypical dementias.
A number of mutations have been demonstrated in the open reading frame (ORF) of the prion protein (PrP) gene in patients with familial Creutzfeldt-Jakob disease or Gerstmann-Sträussler syndrome. On the basis of detecting an insertion in the ORF of the PrP gene in a patient originally suspected to be suffering from familial Alzheimer-type dementia, we screened 101 individuals with atypical dementias for the known PrP gene mutations. Insertions were found in five individuals, whereas none of the other reported mutations in the PrP gene was detected in the present study. One of the five insertions was larger than that described previously, suggesting that the individuals with these mutations are unlikely to be all lineally related and that insertions in the PrP gene may not be uncommon in prion diseases.
Division of Psychiatry, Clinical Research Centre, Harrow, Middlesex, United Kingdom.
F
F
Owen
M
M
Poulter
J
J
Collinge
M
M
Leach
T
T
Shah
R
R
Lofthouse
Y F
YF
Chen
T J
TJ
Crow
A E
AE
Harding
J
J
Hardy
D000544:Alzheimer Disease / Q000235:genetics*; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics*; D004251:DNA Transposable Elements; D003704:Dementia / Q000235:genetics*; D005814:Genes, Viral; D016098:Gerstmann-Straussler-Scheinker Disease / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009693:Nucleic Acid Hybridization; D015345:Oligonucleotide Probes; D016366:Open Reading Frames; D018620:PrPSc Proteins; D011328:Prions / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics*
D003062:Codon; D004251:DNA Transposable Elements; D015345:Oligonucleotide Probes; D018620:PrPSc Proteins; D011328:Prions; D014764:Viral Proteins