Influence of standard and nicotine-reduced cigarette smoke on plasma concentrations of isosorbide dinitrate and its metabolites in rats.
Rats dosed orally with isosorbide dinitrate (1 mg kg-1) were exposed to smoke from standard and nicotine-reduced cigarettes for 8 min using a smoking machine. Plasma concentrations of isosorbide dinitrate and 5-isosorbide mononitrate, one of its major metabolites were approximately equal in the exposed groups, but were lower than in the non-smoking control group. The 2-isosorbide mononitrate concentration was also lower in the group exposed to smoke from standard cigarettes. Since the pharmacokinetics were influenced by smoke from both types of cigarette smoke, the effect may be attributed in large part to non-nicotine components of the smoke.
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Y
Y
Gomita
K
K
Furuno
Y
Y
Araki
D000818:Animals; D002849:Chromatography, Gas; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives / Q000097:blood* / Q000378:metabolism; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012907:Smoking
C030398:isosorbide-2-mononitrate; D009538:Nicotine; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate