Microcomputer adaptation of the wheel-shaped activity monitor: effects of lindane.
The development of microcomputers with increased power and memory capacity may allow for the spreading of the techniques of microanalysis of animal behavior in neurotoxicology. The present work describes the adaptation of the wheel-shaped activity monitor to a personal computer system (IBM-PC/XT/AT-compatible). The system has been used to study the effects elicited by a single 30 mg/kg dose of the organochlorine insecticide gamma-hexachlorocyclohexane (lindane) on the spontaneous behavior of rats. Lindane induced complex changes in behavior, the most prominent being a disruption of the temporal pattern of activity and changes in the local activity/locomotor activity ratios and in place preferences in the monitor. Effects on body weight and number of fecal boluses were also observed.
Llorens
J
J
Department of Neurochemistry, Consejo Superior de Investigaciones Científicas, Barcelona, Spain.
Suñol
C
C
Tusell
J M
JM
D000818:Animals; D003625:Data Collection / Q000295:instrumentation*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008297:Male; D008838:Microcomputers; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001556:Hexachlorocyclohexane