Influence of lipophilic counter ions on the transport of ionizable hydrophilic drugs.
The influence of lipophilic counter ions on the transport of the hydrophilic drugs pholedrine and bretylium across artificial lipid membranes has been studied using a permeation model system. The transport of both drugs was markedly enhanced by hexylsalicylate and by salts of fatty acids with a maximum at decanoate. The transport of pholedrine was additionally increased by bile salts such as desoxycholate.
Sektion Pharmazie, Martin-Luther-Universität, Halle/Saale, Germany.
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Neubert
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Fischer
D001949:Bretylium Compounds / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008567:Membranes, Artificial; D008694:Methamphetamine / Q000031:analogs & derivatives / Q000737:chemistry; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012459:Salicylates / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D001949:Bretylium Compounds; D005227:Fatty Acids; D008055:Lipids; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D012459:Salicylates; C059285:3-hexylsalicylic acid; D008694:Methamphetamine; C005877:pholedrine