[Prostaglandins and damage to the gastric mucosa].
The author critically analyses the involvement of prostaglandins in peptic ulceration. Clinical evidence suggests that for the treatment of peptic ulcer other available drugs (e.g. H2-blockers) are as effective and have fewer side-effects. A potential role in prevention of drug induced gastric mucosal damage (NSAID, ASA) may be verified in further studies.
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Szent-Györgyi Albert Orvostudományi Egyetem, I. sz. Belgyógyászati Klinika.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced; D011453:Prostaglandins / Q000009:adverse effects / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006635:Histamine H2 Antagonists; D011453:Prostaglandins; D001241:Aspirin
A prostaglandinok és a gyomornyálkahártya károsodása.