Relative bioavailability and DNA adduct formation of benzo[a]pyrene and metabolites in the diet of the winter flounder.
1. Radiolabeled metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) were shown to be absorbed through the diet of the winter flounder, Pseudopleuronectes americanus. 2. Oral bioavailability of a mixture of naturally produced metabolites was significantly less than that of the parent BaP. 3. Oral bioavailability of a pure metabolite, BaP-7,8-dihydrodiol (7,8-D) was found to be similar to that of BaP. 4. Both metabolites and BaP formed DNA adducts in liver.
McElroy
A E
AE
Environmental Sciences Program, University of Massachusetts-Boston 02125.
Cahill
J M
JM
Sisson
J D
JD
Kleinow
K M
KM
D000818:Animals; D001564:Benzo(a)pyrene / Q000378:metabolism* / Q000493:pharmacokinetics; D001682:Biological Availability; D004247:DNA / Q000378:metabolism*; D004032:Diet / Q000662:veterinary*; D005432:Flounder / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000378:metabolism* / Q000493:pharmacokinetics
D014874:Water Pollutants, Chemical; D001564:Benzo(a)pyrene; D004247:DNA