[Acute phase reaction in acute viral hepatitis].
We investigated serum concentrations of acute-phase-proteins (alpha 1-antitrypsin (alpha 1-AT), alpha 1-acid glycoprotein (alpha 1-sGP) and C-reactive protein (CRP)), and of complement components C3 and C4 during the course of acute hepatitis A and hepatitis B and correlated it to age and sex of the patients. Whereas a small increase of all three acute-phase-proteins was seen during acute hepatitis A, alpha 1-AT and CRP, but not alpha 1-aGP were found to be elevated during hepatitis B. A moderate elevation of C3 and C4 serum levels, more pronounced in hepatitis B than in hepatitis A, was seen followed by a slow return to normal. A systemic acute phase response seems not to be present during acute viral hepatitis in spite of the pronounced local inflammatory changes in liver tissue.
Abteilung für Kinderinfektionskrankheiten und interne Kinderkrankheiten, Universität Wien.
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Gödl
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Müller
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Wolf
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Eibl
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000175:diagnosis*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000175:diagnosis*; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D008111:Liver Function Tests; D008297:Male
D000209:Acute-Phase Proteins
Akut-Phase-Reaktion bei akuter viraler Hepatitis.