IgG oligoclonal bands in sera of HIV-1 infected patients are mainly directed against HIV-1 determinants.
In a series of 60 HIV-1-infected individuals, serum electrofocusing analysis disclosed clonally restricted IgG patterns in 9 patients (15%), most with limited disease progression (stages WR1-WR3). These oligoclonal bands had a very heterogeneous light chain pattern, and most showed specificity for HIV-1 in affinity-driven transfer studies; virus specificity was more clear-cut following adsorption of sera with the relevant antigen. These findings further stress the profound B-cell function derangement in HIV-1 infection; their possible relevance to AIDS-associated lymphoma development is discussed.
Institute of Oncology, Interuniversity Center for the Research on Cancer, Venice, Italy.
A
A
Amadori
P
P
Gallo
R
R
Zamarchi
M L
ML
Veronese
A
A
De Rossi
D
D
Wolf
L
L
Chieco-Bianchi
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D000939:Epitopes; D006679:HIV Seropositivity / Q000276:immunology / Q000473:pathology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007525:Isoelectric Focusing; D015819:Substance Abuse, Intravenous
D000939:Epitopes; D007074:Immunoglobulin G