Establishment and characterization of a CD5 positive, immunosuppressive human myeloma cell line.
A continuously growing, in vitro cell line with plasma cell characteristics has been established from the bone marrow of a patient with multiple myeloma. Surface marker characterization of the cells revealed a combination of markers normally associated with different developmental stages in the B cell lineage. The cell secretes immunoglobulin at a relatively low rate. The cell also expresses CD5 and secretes a factor which suppresses in vitro mitogen and antigen induced immunoglobulin synthesis by normal PBL.
Scibienski
R J
RJ
Department of Medical Microbiology and Immunology, University of California, Davis 95616.
Paglieroni
T G
TG
MacKenzie
M R
MR
D015703:Antigens, CD / Q000032:analysis*; D000943:Antigens, Differentiation / Q000032:analysis*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018956:CD5 Antigens; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007108:Immune Tolerance; D007136:Immunoglobulins / Q000096:biosynthesis; D007621:Karyotyping; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D009363:Neoplasm Proteins; D014407:Tumor Cells, Cultured / Q000276:immunology / Q000378:metabolism
D015703:Antigens, CD; D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D018956:CD5 Antigens; D006023:Glycoproteins; D007136:Immunoglobulins; D009363:Neoplasm Proteins; C038588:serum immunosuppressive factor, human