Allergy treatment with a peptide vaccine.
An antiserum, obtained by immunising rabbits with a human peptide-protein conjugate, was shown to inhibit histamine release from rat mast cells both in vitro and in vivo. Immunisation of sensitised rats with the same peptide reduced IgE antibody formation and serum histamine concentration, and abolished systemic anaphylactic reactions in response to allergen challenge. This peptide may form the basis of a vaccine in a new approach to the immunotherapy of atopic disease.
Stanworth
D R
DR
Department of Immunology, University of Birmingham Medical School, UK.
Jones
V M
VM
Lewin
I V
IV
Nayyar
S
S
D000818:Animals; D000906:Antibodies / Q000032:analysis; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007106:Immune Sera / Q000008:administration & dosage / Q000276:immunology*; D007114:Immunization / Q000379:methods*; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis / Q000276:immunology; D066298:In Vitro Techniques; D007271:Injections, Intradermal; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D009842:Oligopeptides / Q000138:chemical synthesis / Q000276:immunology*; D010047:Ovalbumin; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects* / Q000276:immunology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000906:Antibodies; D007106:Immune Sera; D007074:Immunoglobulin G; D009842:Oligopeptides; D007073:Immunoglobulin E; D006632:Histamine; D010047:Ovalbumin