Pharmacokinetics of denopamine in hemodialysis patients.
The pharmacokinetics of denopamine on a hemodialysis day and on an interdialysis day was evaluated in 11 hemodialysis patients. Tmax was the only pharmacokinetical parameter that differed significantly between healthy volunteers and hemodialysis patients. It is suggested that denopamine can be administered to hemodialysis both on hemodialysis days and on interdialysis days without dosage adjustments.
First Department of Medicine Osaka University Medical School, Japan.
H
H
Nakahama
M
M
Izumi
Y
Y
Tanaka
A
A
Wada
Y
Y
Fujita
Y
Y
Orita
D
D
Shirai
T
T
Kamada
D000318:Adrenergic beta-Agonists / Q000493:pharmacokinetics*; D000328:Adult; D004983:Ethanolamines / Q000493:pharmacokinetics*; D006801:Humans; D007022:Hypotension / Q000209:etiology; D008297:Male; D012044:Regression Analysis; D006435:Renal Dialysis / Q000009:adverse effects
D000318:Adrenergic beta-Agonists; D004983:Ethanolamines; C037293:denopamine