Inactivation of the unconventional agents of scrapie, bovine spongiform encephalopathy and Creutzfeldt-Jakob disease.
Scrapie, bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease (CJD) are the best known of the transmissible degenerative encephalopathies (TDE) that affect animals and man. Among the unusual properties of the unconventional causal agents is their relative resistance to standard decontamination procedures, and this has resulted in accidental transmission. Scrapie in sheep is the most common of these diseases and, through laboratory studies, is the best understood. As the model for the group, scrapie agent has been used in experiments to devise general standards for decontamination of the agents of the TDE.
AFRC and MRC Neuropathogenesis Unit, Institute for Animal Health, Edinburgh.
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Taylor
D000818:Animals; D001927:Brain Diseases / Q000517:prevention & control* / Q000662:veterinary; D002417:Cattle; D002418:Cattle Diseases; D007562:Creutzfeldt-Jakob Syndrome / Q000517:prevention & control* / Q000635:transmission; D006224:Cricetinae; D004203:Disinfection / Q000379:methods / Q000592:standards*; D006801:Humans; D007757:Laboratory Infection / Q000517:prevention & control / Q000635:transmission; D012106:Research; D012608:Scrapie / Q000517:prevention & control* / Q000635:transmission; D012897:Slow Virus Diseases / Q000517:prevention & control* / Q000635:transmission / Q000662:veterinary