Effects of naloxone on the changes of pain threshold and contents of monoamine neurotransmitters in rat brain induced by EA.
5-HT content in medulla oblongata plus pons and DA level in brain stem obviously increased, while NA concentration in telencephalon markedly decreased in EAA. A previous injection of naloxone, a blocker of opiate receptor, could partially inhibit the EAA, abolish the effects of EA's increasing the 5-HT content in the medulla oblongata plus pons and the DA level in the brain stem, and decrease the NA level in the diencephalon after EA. These results indicate that EA may mediate the metabolism of the central monoamine neurotransmitters partially via opiate receptor to exert its analgesic effect.
Wang
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Y
Institute of Acupuncture, China Academy of TCM.
Wang
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S
Zhang
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W
D015667:Acupuncture Analgesia; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D015671:Electroacupuncture; D009270:Naloxone / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism
D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D012701:Serotonin; D009270:Naloxone; D004298:Dopamine; D009638:Norepinephrine