[Volume replacement with 2 equivalent molecular weight dextrans: effect on erythrocyte elongation in vitro].
The influence of 2 dextranes with the identical molecular weight of 70,000 Dalton for erythrocytes' elongation was investigated in-vitro in 12 healthy male subjects. An increasing dosage between 0.5 and 10 mg/ml Dextran (trade name: Dextran 70 "Ebewe") and Dextran B (weight-equivalent) was added and the elongation index of erythrocytes at shear-rate 50/sec was determined under fluid conditions. Dextran B showed a stronger reduction of elongation index than Dextran A with an elevation of difference up to the highest dosage. The results show that although the molecular weight is identical, differences in hemorheological properties could observed. This should be taken into consideration for volume substitution therapy.
Krankenhaus der Barmherzigen Brüder, Graz-Eggenberg.
P
P
Költringer
W
W
Langsteger
P
P
Lind
G
G
Klima
F
F
Reisecker
O
O
Eber
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects*; D003911:Dextrans / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004907:Erythrocyte Deformability / Q000187:drug effects*; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
D003911:Dextrans
Volumensersatz mit 2 molekulargewichts-äquivalenten Dextranen: Die Wirkung auf die Erythrozytenelongation in vitro.