[Effect of neuroleptic treatment on positive and negative symptoms of schizophrenia and the results of the dexamethasone test].
20 schizophrenic patients (14 men and 6 women), aged 18-50, were studied using the BPRS, Hamilton scale and dexamethasone test before and after treatment with neuroleptic drugs. In the BPRS global rating and positive and negative symptoms rating were analyzed separately. The neuroleptic treatment improved mostly positive symptoms and slightly less depressive symptoms. The smallest effect was exerted on the negative symptoms. The neuroleptic treatment significantly reduced all cortisol levels measured during the dexamethasone test (most the cortisol level measured 17 hours after dexamethasone). The dexamethasone test result normalization depends probably on the neuroleptic treatment -- it did not correlate closely with the clinical improvement.
Katedry i Kliniki Psychiatrii AM w Bydgoszczy.
J
J
Rybakowski
M
M
Linka
D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003907:Dexamethasone; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology
D014150:Antipsychotic Agents; D003907:Dexamethasone; D006854:Hydrocortisone
Wpøyw leczenia neroleptycznego na objawy pozytywne i negatywne schizofrenii oraz wyniki testu deksametazonowego.