Intrauterine insemination as a treatment of infertility in women with antisperm antibodies.
Twenty-four women with infertility caused by antisperm antibodies were treated by homologous intrauterine insemination. Initially, all the women had timed intrauterine insemination by washed spermatozoa for three cycles. The pregnancy rate per couple was 4.20%. The remaining 23 patients received a combined treatment of chlomiphene citrate and intrauterine insemination for three cycles, which did not increase the pregnancy rate per couple and per cycle (4.3% and 1.4% respectively). Thereafter, the remaining 22 patients received a combined treatment of hMG and intrauterine insemination for another three cycles which resulted in a pregnancy rate per cycle (6.1%) and per couple (18.20%) that was significantly greater (P less than 0.01). We conclude that infertile women with antisperm antibodies can benefit after a trial of induction of multiple follicular development with hMG in combination with intrauterine insemination.
Second Department of Obstetrics and Gynecology, University of Athens, Areteion Hospital, Greece.
O
O
Gregoriou
N
N
Vitoratos
C
C
Papadias
S
S
Konidaris
A
A
Maragudakis
P A
PA
Zourlas
D000328:Adult; D000906:Antibodies; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction / Q000379:methods; D013094:Spermatozoa / Q000276:immunology*; D014599:Uterus
D000906:Antibodies; D006063:Chorionic Gonadotropin; D002996:Clomiphene; D008596:Menotropins