Meta-hydroxymexiletine, a new metabolite of mexiletine. Isolation, characterization, and species differences in its formation.
Meta-hydroxymexiletine [1-(3-hydroxy,2,6-dimethyl)phenoxy-2-amino-propane], a novel metabolite of the antiarrhythmic drug mexiletine, was isolated from urine of rats given mexiletine. The structure of the metabolite was elucidated by 1H-NMR and mass spectrometry and by IR spectrophotometry. The metabolite is produced in vitro by hepatic microsomes of various laboratory animals including rat, guinea-pig, hamster, rabbit, and mouse. In humans, meta-hydroxymexiletine accounts for approximately 2% of the administered dose of mexiletine.
Ecole de pharmacie, Université Laval, Que., Canada.
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Grech-Bélanger
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J
Turgeon
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M
Lalande
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PM
Bélanger
D000818:Animals; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D006168:Guinea Pigs; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008647:Mesocricetus; D008801:Mexiletine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism*; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013055:Spectrophotometry, Infrared
C069734:3-hydroxymexiletine; D008801:Mexiletine