Medium term response to H-R erythropoietin in CAPD patients: the influence of erythropoietin plasmatic levels and the effects on peritoneal transport capacity.
Anemia of CRF has been corrected by use of H-R-EPO both in hemodialysis and CAPD patients. Long term response to subcutaneous EPO and its relationship with serum EPO levels remain to be established. Twenty-five CAPD patients treated with CAPD during 30 +/- 28 (mean +/- SD) months were included in this study. The follow-up period was 6-24 months. All patients have been on CAPD at least 6 months and their Hemoglobin (Hb) level was lower than 8.5 g/dl. Twelve patients received EPO by subcutaneous route, at doses of 20 u./Kg daily and 13 other patients at doses of 2000 units twice a week. Thereafter, these doses were adjusted to obtain a Hemoglobin level ranging 10.5-13 g/dl. In conclusion, our results suggest that the subcutaneous route for H-R-Erythropoietin can be considered as the best choice for CAPD patients. Low doses twice a week seem to improve anemia in 2 months. Later, dose adjustment should be done according to the patient's response. The improvement in nutritional status we observed suggests a new positive aspect for EPO therapy. Our data did not show changes in peritoneal function.
Hospital La Paz, Madrid, Spain.
M A
MA
Bajo
R
R
Selgas
B
B
Miranda
A
A
Fernandez-Zamorano
F
F
Borrego
J R
JR
Romero
G
G
Caparros
C
C
Riñon
L
L
Sanchez Sicilia
D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology / Q000628:therapy; D001692:Biological Transport; D003404:Creatinine / Q000378:metabolism; D004921:Erythropoietin / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000503:physiopathology*; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism
D006454:Hemoglobins; D004921:Erythropoietin; D014508:Urea; D003404:Creatinine