[Studies on the T4+2H4+ cell of peripheral blood lymphocyte in systemic lupus erythematosus].
The cell surface phenotype of peripheral blood lymphocytes in patients with systemic lupus erythematosus (SLE) was studied with the anti-T4+, T8+ and T4+2H4+ monoclonal antibodies by flow cytometry. 13 patients with active SLE had a markedly low percentage of T4+2H4+ cells but had normal percentage of T8+ cells. Our results reveal that the influence of T cell to B cell is not only because of the quantity of T cells, also because of the function of T cells. The abnormality of T4+2H4+ cells may be important in the pathogenesis of SLE.
Department of Medicine, Peking Union Medical College Hospital, Beijing.
M
M
Jiang
H Y
HY
Sun
L P
LP
Zu
D000328:Adult; D000911:Antibodies, Monoclonal; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer; D050378:T-Lymphocytes, Regulatory
D000911:Antibodies, Monoclonal