The effect of three intravenous fat emulsions containing different concentrations of linoleic and alpha-linolenic acids on the plasma total fatty acid profile of neonates.
We determined the fatty acid profile of total plasma lipids in infants who received one of three intravenous fat emulsions that differed primarily in their linoleic and alpha-linolenic acid content: (I) a safflower oil emulsion, (II) a 50:50 mixture of safflower and soybean oils, or (III) a soybean oil emulsion. After 2 weeks of fat therapy, oleic acid, expressed as a percentage of total plasma lipid fatty acids, decreased in all groups, but less so in group III (p less than 0.01). The linoleic acid percentage increased in all groups, but group I had the greatest increase (p less than 0.05). Group II patients had higher percentages of the linoleic acid metabolites, dihomo-gamma-linolenic acid (II greater than I, p less than 0.05; II greater than III, p less than 0.01) and arachidonic acid (II greater than III, p less than 0.05). Group II patients also had higher levels of alpha-linolenic acid (II greater than I, p less than 0.05) and its metabolite, eicosapentaenoic acid (II greater than I, p less than 0.05). Another alpha-linolenic acid metabolite, docosahexaenoic acid, however, increased in group III, remained stable in group II, and decreased in group I (III and II greater than I, p less than 0.05). We conclude that the content of linoleic acid and alpha-linolenic acid in intravenous fat emulsions results in statistically significant changes in the fatty acid profile of total plasma lipids in infants receiving total parenteral nutrition.
Department of Pediatrics, Children's Hospital, Ohio State University, Columbus 43205.
R E
RE
McClead
M E
ME
Lentz
J G
JG
Coniglio
H C
HC
Meng
S
S
Gozs
D000367:Age Factors; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001835:Body Weight; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D008041:Linoleic Acids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008042:Linolenic Acids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D011817:Rabbits; D017962:alpha-Linolenic Acid
D001095:Arachidonic Acids; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D008041:Linoleic Acids; D008042:Linolenic Acids; D017962:alpha-Linolenic Acid; D016718:Arachidonic Acid