HLA antigen frequencies and Wegener's granulomatosis.
Previous reports of an association between HLA tissue type and Wegener's granulomatosis are contradictory. By using for the first time a highly sensitive restriction fragment-length polymorphism (RFLP) analysis in addition to standard microcytotoxicity assays, the largest series yet investigated (41 patients) was tissue typed. No association was found between any specific HLA antigen and Wegener's granulomatosis. Although the condition appears to be immunologically mediated, this study indicates that the HLA antigens do not have a major role.
ENT Department, Freeman Hospital, Newcastle upon Tyne, UK.
G E
GE
Murty
B T
BT
Mains
D
D
Middleton
A P
AP
Maxwell
D A
DA
Savage
D000293:Adolescent; D000328:Adult; D000368:Aged; D003601:Cytotoxicity Tests, Immunologic; D014890:Granulomatosis with Polyangiitis / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length
D006680:HLA Antigens