Melanocytic naevi in sun-exposed and protected skin in melanoma patients and controls.
The possible link between exposure to ultraviolet light and naevus development was studied in 121 melanoma patients and 310 controls by comparing the number of naevi in a sun-exposed area on the back with that in a sun-protected area on the buttocks. Both patients and controls had a four-fold increase in the number of naevi in the exposed compared with the protected area, p less than 0.001. The difference in naevus count between the exposed and the protected area was larger in patients than in controls, p less than 0.001. Subjects with dysplastic naevi, melanoma patients as well as controls, had a larger difference in the number of naevi between the two areas than subjects without dysplastic naevi, p less than 0.001. These results support the idea that sunlight plays an important role in naevus development and may explain why a high naevus count is a risk marker for malignant melanoma.
Department of Dermatology, Sahlgrenska Hospital, Göteborg, Sweden.
A
A
Augustsson
U
U
Stierner
I
I
Rosdahl
M
M
Suurküla
D000328:Adult; D016022:Case-Control Studies; D004416:Dysplastic Nevus Syndrome / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000209:etiology*; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000209:etiology*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology*; D013472:Sunlight / Q000009:adverse effects*