Inhibition of membrane potential-dependent amino acid transport by daptomycin.
Daptomycin inhibits the formation of UDP-N-acetylmuramyl-pentapeptide in Bacillus megaterium by inhibiting active transport of amino acids incorporated into the pentapeptide. The ability of daptomycin to inhibit active transport and peptidoglycan formation may be due to its ability to disrupt the transmembrane electrochemical gradient.
Infectious Disease Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285-0428.
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Allen
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Alborn
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Hobbs
D000409:Alanine / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001410:Bacillus megaterium / Q000187:drug effects / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D017576:Daptomycin; D003960:Diaminopimelic Acid / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D018698:Glutamic Acid; D008564:Membrane Potentials / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005971:Glutamates; D010455:Peptides; D018698:Glutamic Acid; D003960:Diaminopimelic Acid; D005947:Glucose; D017576:Daptomycin; D000409:Alanine