Use of anti-collagenase properties of doxycycline in treatment of alpha 1-antitrypsin deficiency panniculitis.
Three patients (a 71-year-old man and 2 women, 73 and 50 years, respectively) with recurrent panniculitis associated with alpha 1-antitrypsin deficiency are presented. Because the concept of chronic and exaggerated inflammatory response in the patients with alpha 1-antitrypsin deficiency is based on the theory of protease-antiprotease imbalance, we suggest that tetracyclines will alleviate this condition. Indeed, tetracyclines were found to inhibit collagenase activity. The total remission of the condition in these 3 patients underlines for the first time the effects of doxycycline on a condition characterized by deficiency of the antiprotease system. A review of the 23 reported cases of panniculitis associated with alpha 1-antitrypsin deficiency is presented in table form.
Humbert
P
P
Department of Dermatology, Hôpital St Jacques, Besançon, France.
Faivre
B
B
Gibey
R
R
Agache
P
P
D000368:Aged; D002908:Chronic Disease; D004318:Doxycycline / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D003012:Microbial Collagenase / Q000187:drug effects; D008875:Middle Aged; D009336:Necrosis; D015434:Panniculitis / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D010641:Phenotype; D000515:alpha 1-Antitrypsin / Q000502:physiology; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin; D003012:Microbial Collagenase; D004318:Doxycycline