Transcriptional regulation of liver-specific gene expression.
Liver-specific gene expression is regulated by four families of transcriptional activatory proteins that are not liver-specific, but are still restricted to a subset of tissues. The current opinion is that liver-specificity is a consequence of the combinatorial action of these factors, which could represent 'functional compartments' coexisting in the hepatocyte.
University of Napoli, Italy.
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De Simone
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Cortese
D000818:Animals; D016632:Apolipoprotein A-I; D001483:Base Sequence; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D008099:Liver / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D014157:Transcription Factors; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D016632:Apolipoprotein A-I; D014157:Transcription Factors