3,4-Methylenedioxymethamphetamine induces Fos-like proteins in rat basal ganglia: reversal with MK 801.
Injections of 3,4-methylenedioxymethamphetamine (MDMA, 25 mg/kg, i.p.) to rats lead to an accumulation of c-fos protein (Fos) and Fos-related antigens in caudate-putamen, nucleus accumbens and olfactory tubercle. This induction occurred at least 2 h (but not at 10 min) after injection and Fos levels had returned to baseline after 24 h, although Fos-related antigens remained elevated 24 h after injection. The NMDA antagonist MK 801 inhibited Fos and Fos-related antigen induction after MDMA injections, whereas fluoxetine, a serotonin uptake inhibitor, had no effect. Thus, MDMA induces Fos and Fos-related antigens in striatal neurons in an NMDA-reversible fashion.
Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, New Zealand.
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Dragunow
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Logan
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Laverty
D015104:3,4-Methylenedioxyamphetamine / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001479:Basal Ganglia / Q000187:drug effects / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D005473:Fluoxetine / Q000494:pharmacology; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D009830:Olfactory Bulb / Q000187:drug effects / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000276:immunology; D016760:Proto-Oncogene Proteins c-fos; D011699:Putamen / Q000378:metabolism; D051381:Rats
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D005473:Fluoxetine; D015104:3,4-Methylenedioxyamphetamine; D016291:Dizocilpine Maleate; D018817:N-Methyl-3,4-methylenedioxyamphetamine