Effects of a protein-bound polysaccharide from a basidiomycetes against hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats.
PSK, extracted from mycelia of a strain of Coriolus versicolor, was administered to groups of 20 male Wistar rats before and during treatment with 3'-methyl-4-dimethylaminoazobenzene (3-MDAB). After 24 weeks, the survival rates were significantly higher in the groups given PSK before or with the 3-MDAB than in groups not given PSK or given PSK after 12 weeks of 3-MDAB treatment. Blood alpha-fetoprotein levels, determined every four weeks, increased in all groups after 3-MDAB treatment, but were significantly lower in the groups given PSK before or with the 3-MDAB than in the other groups. The results indicate that PSK had a suppressive effect on 3-MDAB-induced hepatocarcinogenesis.
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
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Nakajima
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Ichikawa
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Uchida
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Komada
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008749:Methyldimethylaminoazobenzene; D011509:Proteoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D000509:alpha-Fetoproteins / Q000032:analysis
D000903:Antibiotics, Antineoplastic; D011509:Proteoglycans; D000509:alpha-Fetoproteins; C010770:polysaccharide-K; D008749:Methyldimethylaminoazobenzene