Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes.
Dual exposure to Epstein-Barr virus and purified 4-deoxyphorbol ester derived from the plant Euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human B lymphocytes in vitro. Rearrangements most commonly affected chromosome 8, the chromosome most often showing structural changes in Burkitt's lymphoma (BL) cells. E tirucalli is indigenous in parts of Africa where BL is endemic and may be an important risk factor for the disease.
Aya
T
T
Department of Virology, Hokkaido University School of Medicine, Sapporo, Japan.
Kinoshita
T
T
Imai
S
S
Koizumi
S
S
Mizuno
F
F
Osato
T
T
Satoh
C
C
Oikawa
T
T
Kuzumaki
N
N
Ohigashi
H
H
D001402:B-Lymphocytes / Q000187:drug effects / Q000502:physiology*; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000382:microbiology; D002898:Chromosomes, Human, Pair 8 / Q000187:drug effects; D004781:Environmental Exposure; D004854:Herpesvirus 4, Human / Q000502:physiology*; D006801:Humans; D010703:Phorbol Esters / Q000494:pharmacology; D010946:Plants, Medicinal; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D014178:Translocation, Genetic
D010703:Phorbol Esters; D016271:Proto-Oncogene Proteins c-myc