[The effect of somatostatin on specific binding of insulin to receptors in patients with non-insulin dependent diabetes].
Tests were performed of the effects of the Somatostatin (SMS) upon the concentration of Insulin, Glucagon and STH, as well as of the effects of SMS upon the specific binding of the insulin to the receptors. The tests were carried out on eight insulin-independent diabetics, and five healthy volunteers. The tests were made with placebo, followed by 100 ug of the analogue SMS 201-995, known under the name of Sandostatin. Blood specimens for determining all parameters mentioned above were taken at 9 a.m., 3 p.m., 9 p.m., and 3 a.m. (09 h, 15 h, 21, and 03 h). The goal of the tests was to determine whether the SMS had any effect upon the glucoregulation, and at which level changes take place. In the group of healthy volunteers, a considerable decrease of insulin took place six hours after the administration of STH, and the decrease of the glucagon was especially marked, tending to increase again after six hours, while the specific binding of the insulin to the receptors, and the number of receptors were decreased six hours following the administration of the SMS when compared with the placebo, and without tending to reach the previous levels until 3 a.m. (03 h). In insulin-independent diabetics, the SMS leads to a considerable drop of concentrations of Insulin, Glucagon, STH and to a specific binding of the insulin.(ABSTRACT TRUNCATED AT 250 WORDS)
Zamaklar
M
M
Ribarac-Stepić
N
N
Lalić
N
N
Devecerski
M
M
Damjanović
S
S
Djordjević
P
P
D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005934:Glucagon / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology*
D007328:Insulin; D013004:Somatostatin; D013006:Growth Hormone; D005934:Glucagon; D011972:Receptor, Insulin
Efekat somatostatina na specificno vezivanje insulina za receptore u obolelih od insulin nazavisnog dijabetesa.