Intracerebral grafting of fetal dorsal pons in genetically epilepsy-prone rats: effects on audiogenic-induced seizures.
The present experiments investigated if dorsal pontine tissue obtained from 16-day postconception rat fetuses and stereotaxically transplanted into the dorsal hippocampus or third ventricle of genetically epilepsy-prone rats (GEPRs) would alter the expression of audiogenic seizures. Of eight GEPR-9s receiving pontine-tissue grafts bilaterally into the dorsal hippocampus, none showed any reduction in AGS severity. In contrast, three of five GEPR-9s receiving grafts into the third ventricle eventually displayed a decreased seizure severity following transplantation. Of five GEPR-3s receiving transplants into the hippocampus, one animal showed a gradual and significant reduction in seizure severity after transplantation. Tyrosine-hydroxylase (TH) immunohistochemistry showed that transplanted tissue contained abundant TH-immunoreactive profiles including perikarya and fibers. The results of these preliminary studies suggest that the GEPR model of epilepsy may be useful in studying the corrective potential of neurotransplants.
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale 62901.
R W
RW
Clough
R A
RA
Browning
M L
ML
Maring
P C
PC
Jobe
D000161:Acoustic Stimulation; D000375:Aging; D000818:Animals; D016380:Brain Tissue Transplantation / Q000502:physiology*; D002552:Cerebral Ventricles / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology*; D004827:Epilepsy / Q000235:genetics / Q000503:physiopathology*; D016332:Fetal Tissue Transplantation / Q000502:physiology; D005333:Fetus; D006624:Hippocampus / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology*; D011149:Pons / Q000637:transplantation*; D051381:Rats; D011922:Rats, Mutant Strains; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors; D016042:Transplantation, Heterotopic; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D014446:Tyrosine 3-Monooxygenase