v-erbA oncogene abrogates growth inhibition of chicken embryo fibroblasts induced by retinoic acid.
Retinoic acid inhibits chicken embryo fibroblast (CEF) proliferation by altering the G1 phase of the cell cycle with induction of a strong increase in the generation time. This growth-inhibitory response to retinoic acid is abrogated by expression of the v-erbA oncogene, suggesting an interference between retinoic acid receptors and the v-ErbA oncoprotein. Moreover, CEF expressing either the v-src, v-jun or v-fos oncogenes are also insensitive to retinoic acid treatment. In contrast, CEF expressing either the v-myc, v-myb-ets, v-mil, v-sea or v-erbB oncogenes are still sensitive to retinoic acid. These data strongly suggest functional interferences between the retinoic acid receptors and the AP-1 transcription factor complex in the control of expression of genes involved in CEF proliferation.
Immuno-Virologie Moléculaire et Cellulaire, Université Claude Bernard Lyon-1/CNRS UMR 30, Faculté de Médecine Alexis Carrel, Lyon, France.
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Desbois
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Pain
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Guilhot
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Benchaibi
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Ffrench
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Ghysdael
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Madjar
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Samarut
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D002642:Chick Embryo; D003907:Dexamethasone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005347:Fibroblasts / Q000502:physiology*; D005434:Flow Cytometry; D016193:G1 Phase / Q000187:drug effects; D016762:Genes, fos / Q000502:physiology; D016758:Genes, jun / Q000502:physiology; D016259:Genes, myc / Q000502:physiology; D018774:Oncogene Proteins v-erbA; D018739:Oncogene Proteins v-erbB; D020626:Oncogene Proteins v-myb; D027384:Oncogene Proteins v-raf; D009856:Oncogene Proteins, Viral / Q000502:physiology; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics / Q000502:physiology*; D014162:Transfection; D014212:Tretinoin / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology
D018774:Oncogene Proteins v-erbA; D018739:Oncogene Proteins v-erbB; D020626:Oncogene Proteins v-myb; D009856:Oncogene Proteins, Viral; D015682:Retroviridae Proteins, Oncogenic; C055694:env-sea oncogene protein, Avian Erythroblastosis Retrovirus; C050379:oncogene proteins v-ets; D014284:Triiodothyronine; D004958:Estradiol; D014212:Tretinoin; D003907:Dexamethasone; D027384:Oncogene Proteins v-raf