Long-term treatment with Pilogel/beta-blocker in glaucoma patients.
In a multicentre clinical trial thirteen patients with primary open angle glaucoma or ocular hypertension were followed during at least six months while selfinstilling Pilogel (once daily) and topical beta-blocker (twice daily). After six months of combination therapy there was an average decrease in intra-ocular pressure (IOP) of 33.6% 9.5 hours after Pilogel administration and an IOP decrease of 23.4% 22.5 hours after Pilogel administration. With topical beta-blocker alone, an average IOP decrease of 15% was measured. Throughout the study we observed in six patients (46.1%) a superficial punctate keratitis which mostly spontaneously cleared. We did not see any serious side-effects after six months of combination therapy.
Institute of Ophthalmology, University of Nijmegen, The Netherlands.
S
S
Maas
F E
FE
Ros
L J
LJ
De Heer
R J
RJ
De Keizer
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005782:Gels; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000188:drug therapy*; D010862:Pilocarpine / Q000627:therapeutic use*; D011680:Pupil / Q000187:drug effects; D012029:Refraction, Ocular; D014794:Visual Fields / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D005782:Gels; D010862:Pilocarpine