Tetraethylammonium stimulates adrenomedullary secretion by causing fluctuations in a cytosolic free Ca concentration.
Tetraethylammonium (TEA) caused marked fluctuations in a cytosolic free Ca concentration, which was measured by fura-2 microfluorimetry in bovine adrenal chromaffin cells. At the same time. TEA stimulated catecholamine secretion from cat and bovine chromaffin cells. Present results suggest that TEA indirectly increases the Ca2+ influx by depolarizing the cell membrane and consequently stimulates catecholamine secretion.
Department of Physiology, Kagoshima University, School of Medicine, Japan.
M
M
Sorimachi
K
K
Yamagami
S
S
Nishimura
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000313:Adrenal Medulla / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001572:Benzofurans; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D003035:Cobalt / Q000494:pharmacology; D003600:Cytosol / Q000187:drug effects / Q000378:metabolism; D005456:Fluorescent Dyes; D016257:Fura-2; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*
D001572:Benzofurans; D002395:Catecholamines; D005456:Fluorescent Dyes; D013757:Tetraethylammonium Compounds; D003035:Cobalt; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D002118:Calcium; D016257:Fura-2