Low activity of gamma-glutamyl transpeptidase in serum of acute intrahepatic cholestasis.
Low gamma-glutamyl transpeptidase (gamma-GTP) activity in serum was observed in 11 patients with acute intrahepatic cholestasis (cholestatic hepatitis and fulminant hepatitis), despite a marked increase in bilirubin levels. Inhibitors of gamma-GTP were not detected in sera of these patients. Their gamma-GTP levels in the liver were significantly higher than those in chronic liver diseases. An electrophoretic study of liver gamma-GTP in acute intrahepatic cholestasis showed the same mobility as in chronic liver diseases. These results suggest that the low serum gamma-GTP activity in acute intrahepatic cholestasis is due to factors inhibiting the release of the enzyme from the liver.
Kajiwara
E
E
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Akagi
K
K
Tsuji
H
H
Murai
K
K
Fujishima
M
M
D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000032:analysis; D002780:Cholestasis, Intrahepatic / Q000378:metabolism*; D005260:Female; D006505:Hepatitis / Q000150:complications; D006801:Humans; D007527:Isoenzymes; D008099:Liver / Q000201:enzymology*; D008297:Male; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors / Q000097:blood* / Q000378:metabolism
D007527:Isoenzymes; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D001663:Bilirubin