Bethanechol and phenylephrine responses in canine inferior vena cava and abdominal aorta.
Both canine inferior vena cava and abdominal aorta showed a concentration dependent increase of contraction in response to phenylephrine; however, inferior vena cava contracted in response to bethanechol but abdominal aorta did not respond to bethanechol. When the inferior vena cava was preconstricted with 1 x 10(-3)M bethanechol, low concentrations of phenylephrine (1 x 10(-7)M to 1 x 10(-6)M) induced relaxation, but relaxation by phenylephrine of abdominal aorta pretreated with 1 x 10(-3)M bethanechol did not occur.
Wong
K K
KK
Institute of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan.
D000818:Animals; D001012:Aorta, Abdominal / Q000187:drug effects*; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology*; D004285:Dogs; D010656:Phenylephrine / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects; D014682:Vena Cava, Inferior / Q000187:drug effects*
D001626:Bethanechol Compounds; D018723:Bethanechol; D010656:Phenylephrine