Effects of a histamine type-2 receptor antagonist (BMY-25368) on gastric secretion in horses.
The effects of a potent new histamine-2 (H2) receptor antagonist, BMY-25368, were studied on gastric acid secretion in 5 foals from which food was withheld. Doses of 0.02, 0.11, 0.22, and 1.10 mg/kg of body weight were administered IM in a randomly assigned treatment sequence. Following BMY-25368 administration, hydrogen ion concentration was decreased and mean pH was higher than baseline values in a dose-response pattern. At the 0.22 and 1.10 mg/kg doses, the high pH was sustained for greater than 4 hours. The BMY-25368 thus may be useful for treating gastric ulcer disease in horses.
Department of Clinical Studies, School of Veterinary Medicine New Bolton Center, University of Pennsylvania, Kennett Square 19348.
J A
JA
Orsini
D J
DJ
Dreyfuss
J
J
Vecchione
P A
PA
Spencer
R
R
Uhlman
D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006736:Horses; D006863:Hydrogen-Ion Concentration; D010637:Phenolsulfonphthalein / Q000008:administration & dosage; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D011970:Receptors, Histamine H2 / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D006635:Histamine H2 Antagonists; D010880:Piperidines; D011970:Receptors, Histamine H2; C052576:BMY 25368; D010637:Phenolsulfonphthalein