Evoked changes in 5-hydroxytryptamine and norepinephrine release: in vivo dialysis of the rat dorsal horn.
Basal 5-hydroxytryptamine (5HT) and norepinephrine (NE) concentrations were measured in samples collected by in vivo dialysis of the rat dorsal horn. Infusion of KCl, glutamate, and NE by means of the dialysis probe increased NE, but decreased 5HT extracellular concentrations. In contrast, electrical stimulation of the nucleus raphe magnus increased the recovery of both NE and 5HT. These findings suggest differential regulation of noradrenergic and serotonergic nerve terminals modulating nociceptive neurotransmission within the dorsal horn.
Department of Anatomy, Michigan State University, East Lansing 48824-1316.
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RM
Bowker
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Abhold
D000758:Anesthesia; D000818:Animals; D002697:Chloral Hydrate; D003956:Dialysis; D004558:Electric Stimulation; D005971:Glutamates / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011903:Raphe Nuclei / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D013116:Spinal Cord / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*
D005971:Glutamates; D012701:Serotonin; D002697:Chloral Hydrate; D006897:Hydroxyindoleacetic Acid; D011189:Potassium Chloride; D009638:Norepinephrine