Assignment of the gene for intercellular adhesion molecule-1 (Icam-1) to proximal mouse chromosome 9.
Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin superfamily, and a ligand for LFA-1, a beta 2 leukocyte integrin. ICAM-1 has a tissue distribution similar to that of the major histocompatibility complex class II antigens and is likely to play a role in inflammatory responses. We have mapped this gene to proximal mouse chromosome 9 by using mouse-hamster somatic cell hybrids and an interspecies backcross. Since human ICAM-1 maps to chromosome 19, it joins the LDL receptor to establish a new conserved syntenic segment between human chromosome 19 and proximal mouse chromosome 9. Murine Icam-1 maps between Cbl-2 and the centromere in the same region as one of the susceptibility genes for insulin-dependent diabetes mellitus (Idd-2) that is postulated to play a role in immune function and inflammation leading to insulitis. The mapping of Icam-1 to the region known to contain the Idd-2 gene raises the question of whether the phenotypic differences attributed to the Idd-2 locus might be due to genetic variation in Icam-1.
Ballantyne
C M
CM
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030.
Kozak
C A
CA
O'Brien
W E
WE
Beaudet
A L
AL
D000818:Animals; D001345:Autoradiography; D015139:Blotting, Southern; D015815:Cell Adhesion Molecules / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D015342:DNA Probes; D006801:Humans; D006822:Hybrid Cells; D018799:Intercellular Adhesion Molecule-1; D051379:Mice; D009693:Nucleic Acid Hybridization; D013950:Thymus Gland
D015815:Cell Adhesion Molecules; D015342:DNA Probes; D018799:Intercellular Adhesion Molecule-1