[The characteristics of the adrenergic mechanisms regulating the lymph flow in arterial hypertension in dogs].
The influence of i.v. infusion of adrenaline on the lymph flow and arterial pressure was studied in acute experiments on dogs with experimental renovascular hypertension. A reflex increase of the lymph flow by 268% above the initial level was revealed, as well as more obvious alterations in the arterial pressure, decrease of latencies and increase of the response duration in hypertensive dogs as compared with normotensive ones. After infusion of adrenaline together with obsydan we observed the lymph flow to be 2-fold enhanced. Pyrroxan has abolished the effect of adrenaline on alterations in the lymph flow and arterial pressure. Increase of adrenoreactivity of the lymphatic system under hypertension is caused mainly by alpha-adrenoreceptor activation.
L E
LE
Bulekbaeva
K B
KB
Nurgalieva
G A
GA
Demchenko
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D004146:Dioxanes / Q000494:pharmacology; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D008196:Lymph / Q000187:drug effects / Q000502:physiology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D000317:Adrenergic alpha-Antagonists; D004146:Dioxanes; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; C009143:proroxan; D004837:Epinephrine
Osobennosti adrenergicheskikh mekhanizmov reguliatsii limfotoka pri arterial'noĭ gipertenzii u sobak.