Effect of high dose intravenous pulse dexamethasone on lymphocyte phenotypes.
The lymphocyte phenotypes were enumerated in 10 patients with collagen diseases at 0 h, 4 h, 24 h and 7 days after a megadose (100 mg) iv pulse dexamethasone. A significant decrease in CD3 (from a mean of 2324.3/mm3 to 705.9/mm3) and CD4 (from a mean of 1642.6 to 317.6/mm3) cells was observed at 4 h, which recovered partially by 24 h (186.7 and 1226.3/mm3 respectively) and completely at 7 days (2496.1 and 1838.4/mm3). A transient decrease in CD8 cells at 4 h was also observed. There was no significant effect on B cells.
Department of Medicine, All India Institute of Medical Sciences, New Delhi.
A N
AN
Malaviya
R
R
Malaviya
R R
RR
Singh
P C
PC
Negi
A
A
Kumar
A
A
De
S D
SD
Khare
R
R
Sindhwani
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects*; D003095:Collagen Diseases / Q000097:blood; D003907:Dexamethasone / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects; D013997:Time Factors
D000911:Antibodies, Monoclonal; D003907:Dexamethasone