Lipoprotein status in Sprague-Dawley and LA/N-corpulent rats as affected by dietary carbohydrates.
1. To compare the impact of type of carbohydrate, genotype and phenotype on the synthesis and levels of plasma lipoprotein protein. Sprague-Dawley rats and carbohydrate-sensitive LA/N-corpulent (cp) rats were fasted (2 days) and then fed diets containing 54% carbohydrate as either sucrose, fructose or cooked cornstarch for 2 days. 2. The amount of 3H-protein present in the VLDL + chylomicron fraction of Sprague-Dawley rats 2 hr after injection of 3H-leucine was affected by type of dietary carbohydrate: sucrose greater than fructose greater than starch. 3. Obese and lean LA/N-cp rats fed diets containing sucrose or fructose had lower concentrations of HDL protein and higher levels of 3H-protein in VLDL + chylomicron fraction than those fed starch. 4. Obese LA/N-cp rats had more HDL protein and higher levels of 3H-protein in VLDL + chylomicron fraction than their lean littermates.
Carbohydrate Nutrition Laboratory, Human Nutrition Research Center, United States Department of Agriculture, Beltsville, Maryland.
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Ellwood
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Failla
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Reiser
D000818:Animals; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004195:Disease Models, Animal; D004435:Eating / Q000502:physiology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008074:Lipoproteins / Q000096:biosynthesis* / Q000097:blood / Q000302:isolation & purification; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D009765:Obesity / Q000097:blood* / Q000235:genetics; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation / Q000097:blood
D004040:Dietary Carbohydrates; D008074:Lipoproteins; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase