A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19.
Using an interspecific cross, a mouse chromosome 8 linkage map spanning 72 cM has been defined by the segregation of restriction fragment length variants. Linkage and genetic distance were established for 10 loci by analysis of 114 meiotic events and indicated the following gene order: (centromere)-Insr-3.5 cM-Plat-26.3 cM-Crryps/Mel/Jund-3.5 cM-Junb/Ucp-10.5 cM-Mt-1-27.2 cM-Acta2-0.9 cM-Aprt. These data provide further definition of mouse chromosome 8 linkage relationships and the relationship between segments of this chromosome and human chromosomes 8, 16, and 19.
Howard
T A
TA
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Rochelle
J M
JM
Saunders
A M
AM
Seldin
M F
MF
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D002888:Chromosomes, Human, Pair 19; D002898:Chromosomes, Human, Pair 8; D003433:Crosses, Genetic; D015342:DNA Probes; D006239:Haplotypes; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H; D009115:Muridae; D012150:Polymorphism, Restriction Fragment Length
D015342:DNA Probes