Potentiation of bleomycin cytotoxicity in cultured mammalian cells by high molecular weight polyacrylic acid.
The cytotoxicity of bleomycin (BLM) was greatly enhanced in cultured mammalian cell lines in the presence of a low dose of high molecular weight polyacrylate. A decisive lethal event occurred in the cell during vortex-stirring with BLM and polyacrylate. It is possible that a unique mechanism might operate in this synergistic cell killing.
Suzuki
T
T
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Kohda
K
K
Kawazoe
Y
Y
D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001761:Bleomycin / Q000378:metabolism / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006224:Cricetinae; D004357:Drug Synergism; D051379:Mice; D017663:Peplomycin
D000180:Acrylic Resins; D000970:Antineoplastic Agents; D001761:Bleomycin; C006903:carbopol 940; D017663:Peplomycin