Lymphocytic mastopathy. An autoimmune disease of the breast?
Eight cases are reported of an unusual breast lesion consisting of dense intralobular, perilobular, and perivascular lymphocytic infiltrates associated with lobular atrophy and sclerosis. Immunologic studies on paraffin-embedded tissue (seven cases) and frozen tissue (two cases) demonstrated a predominance of B-cells and expression of HLA-DR antigen in involved lobular epithelium. The immunologic features of this lesion are reminiscent of lymphoepithelial lesions of salivary glands and other sites. A possible autoimmune pathogenesis is suggested.
Department of Pathology, Mount Sinai School of Medicine, City University of New York, New York.
I S
IS
Schwartz
J A
JA
Strauchen
D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D001941:Breast Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D000939:Epitopes / Q000032:analysis; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology*; D008413:Mastitis / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged
D000939:Epitopes