[The cytogenetic effect of natural modifiers of mutagenesis in a human lymphocyte culture: the modification of the mutagenic effect by recombinant interferon in vitro in the lymphocytes of bronchial asthma patients and of healthy donors].
The significant protective effect of recombinant interferon in the cultures of lymphocytes of healthy donors and patients with bronchial asthma has been revealed. The cytogenetic damage were stimulated by alkylating agents thioTEPA and photrin during their administration at the stages Gi-S of the cell cycle. No differences were revealed in the action of mutagens and protector in the patients and healthy persons.
Movsesian
E S
ES
Sarkisian
T F
TF
Arutiunian
R M
RM
D001249:Asthma / Q000097:blood*; D001388:Aziridines / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008677:Metaphase / Q000187:drug effects; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D011994:Recombinant Proteins / Q000494:pharmacology; D013852:Thiotepa / Q000494:pharmacology
D001388:Aziridines; D009153:Mutagens; D011994:Recombinant Proteins; C007779:fotrin; D007372:Interferons; D013852:Thiotepa
Tsitogeneticheskiĭ éffekt estestvennykh modifikatorov mutageneza v kul'ture limfotsitov cheloveka: modifikatsiia mutagennogo éffekta rekombinantnym interferonom in vitro v limfotsitakh bol'nykh bronkhial'noĭ astmoĭ i zdorovykh donorov.