Neutralization of toxic effects of different crude jellyfish venoms by an extract of Ipomoea pes-caprae (L.) R. Br.
An extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br., previously shown to be clinically effective toward dermatitis caused by venomous jellyfishes, was studied as to its ability to neutralize toxic activities of jellyfish venoms. Different venoms exhibited different degrees of activity. When IPA was incubated with active venoms, it inhibited the actions of all jellyfish venoms tested, with IC50 values in the range of 0.3-0.8 mgIPA/mg venom for proteolytic action, and with about 10 times lower IC50 values for the neutralization of haemolytic action. These activities of IPA support the previously reported effectiveness in the treatment of dermatitis caused by jellyfish sting.
Department of Pharmacognosy, Uppsala University, Sweden.
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Pongprayoon
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Bohlin
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Wasuwat
D000818:Animals; D000997:Antivenins / Q000302:isolation & purification / Q000627:therapeutic use*; D003064:Cnidarian Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity; D003872:Dermatitis / Q000188:drug therapy* / Q000209:etiology; D006168:Guinea Pigs; D006801:Humans; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D037401:Scyphozoa; D013785:Thailand
D000997:Antivenins; D003064:Cnidarian Venoms; D010936:Plant Extracts