[The anti-arrhythmia action of combinations of N-propylajmaline bromide with anti-arrhythmia agents of different classes].
In experiments on 68 dogs with ventricular arrhythmia at the late stage of experimental myocardial infarction caused by the coronary artery branch occlusion it was shown that combinations of N-propylaimaline bromide (IA class of antiarrhythmic agents) with trimecaine (IB class) or anapriline (II class) or phynoptine (IV class) induce a significant increase of the antiarrhythmic effect that is not observed at combination of N-propylaimaline with ethmosine (the both antiarrhythmic drugs belong to IA class). This potentiating effect is thought to be related to differences in the molecular mechanisms of action of antiarrhythmic drugs.
Gendenshteĭn
E I
EI
Balashov
V P
VP
Kostin
Ia V
IaV
Oleĭnikov
V E
VE
D000404:Ajmaline / Q000031:analogs & derivatives*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy / Q000209:etiology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy; D011219:Prajmaline / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D000404:Ajmaline; D011219:Prajmaline
Protivoaritmicheskoe deĭstvie kombinatsiĭ N-propilaĭmalinbromida s protivoaritmicheskimi preparatami raznykh klassov.