MspI polymorphic site in intron 22 of the factor VIII gene in the Japanese population.
A novel MspI DNA polymorphic site has been found in intron 22 of the human factor VIII gene. This site is informative almost exclusively in the Japanese population (heterozygosity 0.45) and will be of considerable importance in carrier detection and prenatal diagnosis of hemophilia A in this population.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
H
H
Inaba
M
M
Fujimaki
H H
HH
Kazazian
S E
SE
Antonarakis
D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific; D005169:Factor VIII / Q000235:genetics*; D006801:Humans; D007438:Introns; D007564:Japan; D012150:Polymorphism, Restriction Fragment Length
D005169:Factor VIII; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific