Somatostatin promotes accumulation of phospholipids in regenerating liver tissue of rats.
Effects of somatostatin (SOM) on tissue contents of proteins, total lipids and phospholipids were investigated in regenerating and intact liver tissue of Y-59 rats. Whereas SOM inhibited protein accumulation in regenerating liver, the hormone evoked an increase in total lipids, and specially in phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine (PS) and phosphatidylinositol (PI). Since the same effects were not seen when intact liver was analyzed, it is assumed that SOM acts primarily on tissue stimulated to rapid growth. The increase of PS + PI fractions indicates a specific effect of SOM on the metabolism of phosphatidylinositides. Such an effect might result from the interference of the hormone with the action of growth factors that accelerate phosphatidylinositol breakdown.
Milin
C
C
Department of Chemistry and Biochemistry, University Vladimir Bakaric, Rijeka, Yugoslavia.
Radosevic-Stasic
B
B
Kirigin
M
M
Hinic
V
V
Rukavina
D
D
Berggren
P O
PO
Efendic
S
S
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D008110:Liver Extracts / Q000378:metabolism; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology*
D008110:Liver Extracts; D010743:Phospholipids; D011506:Proteins; D013004:Somatostatin