Central nervous system site of action of bombesin to elevate plasma concentrations of catecholamines.
To identify the central nervous system site of action of bombesin to elevate plasma concentrations of catecholamines, this peptide has been injected into numerous brain ventricular and parenchymal sites. Low doses of bombesin (1-10 ng) injected into the region of the rostral nucleus tractus solitarius (NTS) elicited an elevation of plasma catecholamines greater than those observed following an injection of bombesin into other brain regions. Bombesin-induced (10 ng) elevation of plasma epinephrine but not norepinephrine was prevented by co-administration of somatostatin-28 (100 ng). Mean arterial pressure (MAP) and heart rate (HR) were measured following injection of bombesin into the NTS. Bombesin injected into the NTS resulted in prolonged decreases in HR without significantly altering MAP. These studies demonstrate that bombesin injected into the dorsal medulla resulted in significant changes of plasma catecholamine levels and HR. Based on these actions of bombesin and the neuroanatomic distribution of bombesin-like peptide, it is suggested that this peptide may play an important role in regulation of sympatho-adrenal and cardiac functions.
Department of Medicine, University of California, San Diego, La Jolla 92093.
K
K
Carver-Moore
T S
TS
Gray
M R
MR
Brown
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001933:Brain Stem / Q000033:anatomy & histology; D002395:Catecholamines / Q000097:blood*; D004837:Epinephrine / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000494:pharmacology; D053561:Somatostatin-28
D002395:Catecholamines; D013004:Somatostatin; D053561:Somatostatin-28; D001839:Bombesin; D009638:Norepinephrine; D004837:Epinephrine