[Double-stranded RNA from phage F6: its interferon-inducing and antiviral properties].
Double stranded RNA was isolated from bacteriophage phi 6 parasitizing on phytobacteria. Its interferon-inducing and antiviral activities were shown in vitro and in vivo. In the culture of L-929 cells, interferon resistant to heat and acids was synthesized. The interferon could be practically completely neutralized by specific anti-interferon serum. The phage phi 6 preparation dsRNA in the lyophilized form was studied. The preparation retained its biological activity. It was shown that a preparation containing 30 per cent of dsRNA was less toxic than a preparation containing 100 per cent of dsRNA, the difference in the interferon-inducing activity being insignificant.
Nosik
N N
NN
Pugachev
V G
VG
Ershov
F I
FI
D000818:Animals; D000998:Antiviral Agents; D001435:Bacteriophages / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D004686:Encephalomyocarditis virus; D004769:Enterovirus Infections / Q000188:drug therapy*; D066298:In Vitro Techniques; D007369:Interferon Inducers; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D011549:Pseudomonas; D012329:RNA, Bacterial / Q000008:administration & dosage / Q000502:physiology* / Q000627:therapeutic use; D012330:RNA, Double-Stranded / Q000008:administration & dosage / Q000502:physiology* / Q000627:therapeutic use; D011817:Rabbits
D000998:Antiviral Agents; D007369:Interferon Inducers; D012329:RNA, Bacterial; D012330:RNA, Double-Stranded; D007372:Interferons
Dnunitevaia RNK faga F6: interferonindutsiruiushchie i protivovirusnye svoĭstva.