[Ionic selectivity of melittin-modified flat lipid bilayers].
It has been established in experiments with the bilayer lipid membranes (BLM) that at pH greater than 6.6 the melittin pores are cation-selective and at lower pH they are more selective by anions. The property of melittin pores is shown to be provided by the amino group of the N-terminal glycine residue. The selectivity of melittin-containing membranes may be controlled by the transmembrane potential, the cross-section of water pores being changed. The data obtained are explained within the alimethicine-like model.
R Z
RZ
Sabirov
O V
OV
Krasil'nikov
E G
EG
Kostrzhevskaia
D001514:Bee Venoms / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism*; D008555:Melitten / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D010539:Permeability
D001514:Bee Venoms; D007473:Ion Channels; D008051:Lipid Bilayers; D008555:Melitten
Ionnaia izbiratel'nost' modifitsirovannykh melittinom ploskikh lipidnykh bisloev.