Ventricular couplets in the young: prognosis related to underlying substrate.
Ventricular couplets may be a risk factor for sudden death in adults, but their prognosis in children is unknown. From 1981 to 1987 104 patients, mean age 13.2 years (0.2 to 37 years), had ventricular couplets on a 24-hour electrocardiogram (ECG) (Holter monitor) and on follow-up with a second Holter (mean, 2.5 years). Of the 104 patients, 22 had a normal heart and 82 had an abnormal heart. Patients with a normal or an abnormal heart did not differ in incidence or severity of symptoms (patients with a normal heart had 17 instances of palpitations and none of syncope; patients with an abnormal heart had 49 instances of palpitations, six of dizziness, and none of syncope). Number of ventricular couplets was higher in patients with a normal heart (33 +/- 50/day: mean +/- 1 SD) than in those with an abnormal heart (17 +/- 15/day; p less than 0.05). Of the 22 patients with a normal heart, 11 underwent an electrophysiologic study (EPS); none had inducible ventricular tachycardia. After mean follow-up of 29.7 months, all 22 patients with a normal heart were alive without ventricular tachycardia; 6 of 22 were treated for palpitations, with complete suppression of couplets in two. In 11 of 16 untreated patients with a normal heart, ventricular couplets disappeared spontaneously. Of the 82 patients with an abnormal heart, 32 had an EPS: nine (28%) had sustained ventricular tachycardia, 16 (50%) had nonsustained ventricular tachycardia, and seven (22%) had no inducible ventricular tachycardia. ECG criteria and hemodynamic status were of limited value in predicting inducibility of ventricular tachycardia.(ABSTRACT TRUNCATED AT 250 WORDS)
Department of Pediatrics, Baylor College of Medicine, Houston, TX.
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T
Paul
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C
Marchal
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Garson
D000293:Adolescent; D005117:Cardiac Complexes, Premature / Q000175:diagnosis* / Q000209:etiology; D002648:Child; D003645:Death, Sudden / Q000453:epidemiology; D015716:Electrocardiography, Ambulatory; D004594:Electrophysiology; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000150:complications*; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013610:Tachycardia / Q000175:diagnosis