Biochemical and biological properties of methotrexate analogs containing D-glutamic acid or D-erythro, threo-4-fluoroglutamic acid.
McGuire
J J
JJ
Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, NY 14263.
Bolanowska
W E
WE
Coward
J K
JK
Sherwood
R F
RF
Russell
C A
CA
Felschow
D M
DM
D002455:Cell Division / Q000187:drug effects; D002460:Cell Line / Q000187:drug effects / Q000201:enzymology; D005493:Folic Acid Antagonists; D005971:Glutamates; D018698:Glutamic Acid; D006801:Humans; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D013237:Stereoisomerism; D013938:Thymidine Monophosphate / Q000096:biosynthesis; D011623:gamma-Glutamyl Hydrolase / Q000378:metabolism
D005493:Folic Acid Antagonists; D005971:Glutamates; C036539:fluoresceinated methotrexate; C038473:4-fluoroglutamic acid; D013938:Thymidine Monophosphate; D018698:Glutamic Acid; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate