Brain beta-adrenoceptor binding sites in depressed suicide victims: effects of antidepressant treatment.
beta-Adrenoceptor binding sites were measured by saturation binding of [3H]CGP 12177 in nine brain regions from 13 suicides, with a firm retrospective diagnosis of depression, who had been receiving antidepressant drugs, and 11 matched controls. Significantly lower numbers of beta-adrenoceptor binding sites were found in thalamus and temporal cortex (Brodmann area 38), but not in other brain regions, of antidepressant-treated suicides compared to controls. The lower number of beta-adrenoceptor binding sites in thalamus appeared to be related to drug treatment, whereas lower numbers of beta-adrenoceptors in temporal cortex were also found in antidepressant-free suicides.
Department of Pharmacology and Clinical Pharmacology, St. George's Hospital Medical School, London, UK.
F
F
De Paermentier
S C
SC
Cheetham
M R
MR
Crompton
C L
CL
Katona
R W
RW
Horton
D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000506:poisoning / Q000627:therapeutic use*; D001923:Brain Chemistry / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D003863:Depression / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013405:Suicide; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D000928:Antidepressive Agents; D011412:Propanolamines; D011943:Receptors, Adrenergic, beta; C033394:CGP 12177