[Changes in the activity of the taste receptor apparatus and the preference for a sodium chloride solution in newborn rats receiving capsaicin].
Taste receptor organ activity and preference of sodium chloride solution in rats with deficit of substance P (SP) were studied. Total impulse activity of chorda tympani nerve of 7-8 week old rats was recorded under nembutal anesthesia. The taste responses to four solutions (sucrose, quinine sulfate, sodium chloride and citric acid) were decreased in rats injected with capsaicin in comparison with rats injected with vehicle. The rats injected with capsaicin preferred water to sodium chloride (two-bottle technique). On the contrary the rats injected with capsaicin preferred the salt solution. These data together with previous studies show the important role of peptide SP in taste receptor activity and "salt appetite".
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D000818:Animals; D000831:Animals, Newborn; D002211:Capsaicin / Q000494:pharmacology*; D002814:Chorda Tympani Nerve / Q000187:drug effects / Q000502:physiology; D004327:Drinking Behavior / Q000187:drug effects* / Q000502:physiology; D004594:Electrophysiology; D005260:Female; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*; D012996:Solutions; D013373:Substance P / Q000172:deficiency / Q000502:physiology; D013650:Taste Buds / Q000187:drug effects* / Q000502:physiology
D012996:Solutions; D013373:Substance P; D012965:Sodium Chloride; D002211:Capsaicin
Izmeneniia aktivnosti vkusovogo retseptornogo apparata i predpochteniia rastvora natriia khlorida u novorozhdennykh krys, poluchavshikh kapsaitsin.