Interleukin-2 production of T cells in atopic dermatitis.
Patients with atopic dermatitis (AD) were treated with Tranilast, Interleukin-2 (IL-2) (production of T cells in vitro) and blood histamine values, before and after Tranilast therapy, were measured, and the following results were obtained: 1) Compared with healthy controls, the IL-2 producing ability of T cells in patients with AD was increased. 2) After Tranilast therapy, IL-2 production of T cells in AD decreased in quantity to the control level. 3) Skin lesion severities of AD were correlated with the quantity of IL-2 production of T cells. 4) Serum histamine levels were not significantly different between AD patients and healthy controls, before or after Tranilast therapy.
Morita
H
H
Department of Dermatology, Hyogo College of Medicine, Japan.
Kihara
T
T
Miyamoto
M
M
Yamagata
M
M
Sagami
S
S
D000328:Adult; D002648:Child; D003876:Dermatitis, Atopic / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006632:Histamine / Q000097:blood; D006801:Humans; D007376:Interleukin-2 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D062367:ortho-Aminobenzoates / Q000008:administration & dosage / Q000494:pharmacology*
D007376:Interleukin-2; D062367:ortho-Aminobenzoates; D006632:Histamine; C012293:tranilast