[The experimental anti-arrhythmia properties of the histamine H1 receptor blockader fencarol].
Phencarol, a blocker of H1-histamine receptors, is used as an antihistaminic agent. The antiarrhythmic effect of phencarol was detected and studied on experimental models of arrhythmias in non-anesthetized rabbits in a dose of 5 mg/kg intravenously. The drug was shown to possess the pronounced antiarrhythmic and protective properties on the models of calcium-chloride-, adrenaline- and strophanthine-induced arrhythmias and to exert no influence on aconitine-induced arrhythmia. Phencarol was demonstrated to have no cardiodepressive effect.
Iakovlev
G M
GM
Skorobogatov
V I
VI
Svistov
A S
AS
Mironova
M I
MI
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D001559:Benzhydryl Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006634:Histamine H1 Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits
D000889:Anti-Arrhythmia Agents; D001559:Benzhydryl Compounds; D006634:Histamine H1 Antagonists; C014742:quifenadine
Antiaritmicheskie svoĭstva blokatora H1-gistaminovykh retseptorov fenkarola v éksperimente.