Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids in malnourished developing rats.
The effect of a low protein diet during pregnancy and lactation on the fatty acid composition of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) from brains of ten-day-old rats was studied. The results indicated that partial deprivation of protein during early development was associated with an increase in the fatty acids of the n-9 family in PC. The fatty acids of the linoleic acid series decreased in PE but were not modified in PC. These minor changes did not affect the double bond index values either in PC or in PE. The effect of protein depletion on the in vivo metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids was also studied. The percentage distribution of the labeled precursors and their derivatives among PC and PE differed from that of mass distribution. These results indicate that the direct uptake of polyunsaturated fatty acids from the blood and/or the low turnover rate of these acids incorporated into PC and PE might be involved in maintaining the fatty acid pattern of these brain lipids.
Instituto de Investigaciones Bioquimicas de La Plata (INIBIOLP), Facultad de Ciencias Medicas, Argentina.
M E
ME
de Tomás
O
O
Mercuri
C
C
Serres
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D000833:Animals, Suckling / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D007276:Injections, Intraventricular; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000378:metabolism*; D008042:Linolenic Acids / Q000378:metabolism*; D008297:Male; D010713:Phosphatidylcholines / Q000737:chemistry; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011247:Pregnancy; D011248:Pregnancy Complications; D011488:Protein Deficiency / Q000378:metabolism*; D051381:Rats; D017962:alpha-Linolenic Acid
D005227:Fatty Acids; D008041:Linoleic Acids; D008042:Linolenic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D017962:alpha-Linolenic Acid; D019787:Linoleic Acid