Antibacterial properties of the bicyclic pyrazolidinones.
LY173013 and LY186826 are bicyclic pyrazolidinones containing a novel aza-gamma-lactam ring structure. The antibacterial properties of these compounds appear to be related to those of beta-lactam antibiotics in that both classes of compounds share certain common binding molecules such as beta-lactamases and penicillin-binding proteins.
Allen
N E
NE
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
Hobbs
J N
JN
Preston
D A
DA
Turner
J R
JR
Wu
C Y
CY
D000409:Alanine / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000648:ultrastructure; D001426:Bacterial Proteins / Q000096:biosynthesis; D002352:Carrier Proteins / Q000378:metabolism; D002473:Cell Wall / Q000187:drug effects; D004269:DNA, Bacterial / Q000096:biosynthesis; D004754:Enterobacter / Q000187:drug effects / Q000201:enzymology; D006602:Hexosyltransferases; D015394:Molecular Structure; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D011532:Providencia / Q000187:drug effects; D011720:Pyrazoles / Q000032:analysis* / Q000494:pharmacology*; D012329:RNA, Bacterial / Q000096:biosynthesis; D013844:Thiazoles / Q000032:analysis* / Q000494:pharmacology*; D001618:beta-Lactamases / Q000378:metabolism; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D004269:DNA, Bacterial; D046915:Penicillin-Binding Proteins; D011720:Pyrazoles; D012329:RNA, Bacterial; D013844:Thiazoles; D047090:beta-Lactams; C063296:LY 173013; C063297:LY 186826; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases; D000409:Alanine