[The isolation and study of the properties of current influenza A viruses (H1N1) with a natural resistance to remantadine].
Studies of influenza A viruses (H1N1) isolated in 1985-1988 revealed 4 strains with natural resistance to chemical drugs (remantadine, adapromine, deitiforin). Three of them were isolated in Mongolia (A/Mongolia/230/85, A/Mongolia/231/85, and A/Mongolia/128/86) and one in the USSR (A/Moscow/771/88). These strains differed from other isolates by the following features: (i) antigenic remoteness from reference A/Chile/1/83 and A/Taiwan/1/86; (ii) similarity in antigenic specificity with A/Khabarovsk/74/77; (iii) resistance to chemical drugs; (iv) high electrophoretic mobility of genes M and NS in PAG. The possible origin of these strains is discussed.
Kozeletskaia
K N
KN
Grinbaum
E B
EB
Zhamsrangiĭn
M
M
Burmistrova
V V
VV
Kiselev
O I
OI
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000037:antagonists & inhibitors; D002642:Chick Embryo; D004352:Drug Resistance, Microbial; D000939:Epitopes / Q000032:analysis; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification*; D009930:Organic Chemicals; D012367:RNA, Viral / Q000032:analysis / Q000302:isolation & purification; D012299:Rimantadine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors*
D000954:Antigens, Surface; D000956:Antigens, Viral; D000998:Antiviral Agents; D000939:Epitopes; D009930:Organic Chemicals; D012367:RNA, Viral; D012299:Rimantadine; C060204:deitiforin; C052262:adapromine
Vydelenie i izuchenie svoĭstv sovremennykh virusov grippa A (H1N1) s prirodnoĭ rezistentnost'iu k remantadinu.