Thyrotropin-releasing hormone excites submucous neurons in guinea-pig ileum.
Actions of thyrotropin-releasing hormone (TRH) on submucous neurons of the guinea-pig ileum were examined with intracellular electrophysiological methods. TRH evoked excitatory responses in S/type 1 and AH/type 2 neurons. The responses consisted of slowly activating membrane depolarization, augmented excitability and an increase in input resistance that resulted from a decrease in potassium conductance. The results suggest a neuromodulatory/neurotransmitter function for TRH.
Department of Physiology, College of Medicine, Ohio State University, Columbus 43210.
D H
DH
Zafirov
H J
HJ
Cooke
J D
JD
Wood
D000818:Animals; D004594:Electrophysiology; D006168:Guinea Pigs; D007082:Ileum / Q000294:innervation*; D066298:In Vitro Techniques; D009474:Neurons / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D013368:Submucous Plexus / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D018377:Neurotransmitter Agents; D013973:Thyrotropin-Releasing Hormone