[Effects of dermorphin on processes of cell division in the corneal and tongue epithelium of white rats].
The character of dermorphin influence on cell division in corneal and tongue epithelium of white rats was studied by the method of radioautography with 3H-thymidine. The effect of dermorphin was distinct from the effect of delta-receptors ligands on the cell division processes in corneal and tongue epithelium of experimental animals. The injection of dermorphin in dose 10 micrograms/kg compressed the DNA-synthesis in 4 and 24 hours since the moment of administration. The mitotic index increased in 4 hours and decreased in 24 hours.
Radivoz
M I
MI
Mel'nik
E I
EI
Timoshin
S S
SS
Deĭgin
V I
VI
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects*; D003315:Cornea / Q000166:cytology / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D008297:Male; D008940:Mitotic Index; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D051381:Rats; D014059:Tongue / Q000166:cytology / Q000187:drug effects*
D000701:Analgesics, Opioid; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D004247:DNA
Vliianie dermorfina na protsessy kletochnogo deleniia v épitelii rogovitsy i iazyka belykh krys.