Phenotypic analysis of lymphoblastoid cell lines derived from cattle and deer affected with "sheep-associated" malignant catarrhal fever.
Established lymphoblastoid cell lines with natural killer cell-like activity have been derived from cattle and deer affected with malignant catarrhal fever. They were examined phenotypically using monoclonal antibodies chosen for their cross-reactivity with peripheral blood lymphocytes from these species. Cell lines established from three of four cattle were identified as cytotoxic/suppressor lymphocytes (CD4-/CD8+/T19-) whilst the other was shown to be of the helper cell phenotype (CD4+/CD8-/T19-). Two other cell lines, one derived from a red deer and the other from a Père David's deer, were both CD4-/CD8-/T19. All of the lines examined expressed a T cell receptor (CD2+).
Moredun Research Institute, Edinburgh, UK.
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D000818:Animals; D000911:Antibodies, Monoclonal; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002417:Cattle; D002469:Cell Separation; D003429:Cross Reactions; D003670:Deer / Q000276:immunology*; D005434:Flow Cytometry; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology*; D008304:Malignant Catarrh / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D012756:Sheep; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014407:Tumor Cells, Cultured
D000911:Antibodies, Monoclonal; D011948:Receptors, Antigen, T-Cell