Selective alpha 2-adrenergic agonists B-HT 920 and UK14304-18. Effects on aqueous humor dynamics in monkeys.
Selective alpha 2-adrenergic agonists UK14304-18 and B-HT 920 were evaluated in the eyes of cynomolgus monkeys. In normal monkeys, unilateral topical application of 0.3%, 0.5%, or 1% UK14304-18 or B-HT 920 reduced (P less than .05) intraocular pressure bilaterally up to 9.9 +/- 1.2 mm Hg (mean +/- SEM) and 8.4 +/- 1.4 mm Hg in treated and contralateral eyes, respectively. Five-day twice-daily 0.5% UK14304-18 administration reduced (P less than .05) intraocular pressure up to 49% in eight glaucomatous monkeys. In eight normal monkeys, 0.5% B-HT 920 and 0.5% UK14304-18 produced no alterations in outflow facility. Following unilateral application of 0.5% B-HT 920 or 0.5% UK14304-18, fluorophotometrically measured aqueous humor production was reduced (P less than .05) bilaterally up to 67% compared with baseline values. Also, 0.5% UK14304-18 reduced (P less than .025) systolic and diastolic blood pressure. UK14304-18 and B-HT 920 seem to reduce intraocular pressure by decreasing aqueous production. They are potential new agents for the treatment of glaucoma.
Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY 10029.
J B
JB
Serle
S
S
Steidl
R F
RF
Wang
T W
TW
Mittag
S M
SM
Podos
D000287:Administration, Topical; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D001381:Azepines / Q000494:pharmacology*; D000068438:Brimonidine Tartrate; D007429:Intraocular Pressure / Q000187:drug effects; D008252:Macaca fascicularis; D011810:Quinoxalines / Q000494:pharmacology*; D013997:Time Factors; D014065:Tonometry, Ocular
D000316:Adrenergic alpha-Agonists; D001381:Azepines; D011810:Quinoxalines; D000068438:Brimonidine Tartrate; C024763:talipexole