CHox E, a chicken homeogene of the H2.0 type exhibits dorso-ventral restriction in the proliferating region of the spinal cord.
CHox E is a novel chicken homeogene that belongs to the H2.0 family of homeodomains. Its homeobox sequence is interrupted by an intron between amino acids 44 and 45. Expression of CHox E during embryogenesis is localized to the central nervous system. The anterior boundary of CHox E expression can initially be localized to rhombomere number 1, later in development this boundary reaches up to the rhombencephalic isthmus. CHox E expression in the spinal cord localizes dorso-ventrally to the dorsal half of the basal plate. CHox E expression is always restricted to the proliferating region, the ventricular zone. As the ventricular zone becomes restricted laterally, so does the CHox E expressing region. Once this region of the ventricular zone ceases to exist, CHox E specific transcripts become undetectable. The site and time of CHox E expression suggest a very early function in the differentiation of the cells derived from that region of the ventricular zone.
Rangini
Z
Z
Department of Genetics, Hebrew University, Jerusalem, Israel.
Ben-Yehuda
A
A
Shapira
E
E
Gruenbaum
Y
Y
Fainsod
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002642:Chick Embryo; D004247:DNA / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D005801:Genes, Homeobox / Q000235:genetics / Q000502:physiology*; D007438:Introns; D008969:Molecular Sequence Data; D009474:Neurons / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D014158:Transcription, Genetic / Q000235:genetics
D004247:DNA