Expression of Fc epsilon R2/CD23 on peripheral blood macrophages/monocytes in Kawasaki disease.
We analyzed the expression of Fc epsilon R2/CD23 on peripheral blood macrophages/monocytes in 12 patients with Kawasaki disease (KD) using a fluorescence-activated cell sorter. The absolute counts of CD14+ macrophages/monocytes and CD23+ macrophages/monocytes were high, and were positively correlated during the acute stage of KD. These results indicate that the increased number of macrophages/monocytes during acute KD have the Fc epsilon R2/CD23 antigen present on the surface of the cells, suggesting that peripheral blood macrophages/monocytes have been activated.
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
S
S
Furukawa
T
T
Matsubara
T
T
Motohashi
S
S
Nakachi
K
K
Sasai
K
K
Yabuta
D000208:Acute Disease; D015703:Antigens, CD / Q000032:analysis*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis* / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D018950:Lipopolysaccharide Receptors; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology*; D011961:Receptors, Fc / Q000032:analysis* / Q000378:metabolism*; D017455:Receptors, IgE
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D015214:Antigens, Differentiation, Myelomonocytic; D018950:Lipopolysaccharide Receptors; D011961:Receptors, Fc; D017455:Receptors, IgE; D007073:Immunoglobulin E