Dietary obesity shows adaptations of amino-acid metabolism on enzyme activities to save amino nitrogen.
An increased aspartate transaminase in the liver of dietary (post-cafeteria) obese rats was found. It was consistent with the functionality of the malate-aspartate shuttle, that could be responsible for enhancement of metabolic efficiency. The muscle and intestine of obese rats showed a greater capacity for alanine and glutamine synthesis than the controls. Furthermore, enterocyte adaptations in the obese rats indicated higher capabilities for the intake of nitrogen than in the controls. In conclusion, the pattern of amino-acid enzyme activities reflected adaptations to keep from amino nitrogen depletion in dietary obesity which were compatible with an enhancement of the metabolic efficiency.
Dpt. de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears (UIB), Palma de Mallorca 07071, Spain.
F
F
Serra
M
M
Gianotti
A
A
Palou
A
A
Pons
D000659:AMP Deaminase / Q000378:metabolism; D000222:Adaptation, Physiological; D000410:Alanine Transaminase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D005260:Female; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005974:Glutamate-Ammonia Ligase / Q000378:metabolism; D007421:Intestine, Small / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D009584:Nitrogen / Q000378:metabolism*; D009765:Obesity / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000659:AMP Deaminase; D005974:Glutamate-Ammonia Ligase; D009584:Nitrogen