Studies on the mutagenicity of a zinc oxide-hexachloroethane smoke.
1. A suitable method has been developed for generating atmospheres of zinc oxide/hexachloroethane smoke (ZnHCE). 2. The smoke was investigated using the Ames test and the micronucleus assay. 3. It was weakly mutagenic to the bacteria, but in the bone marrow no increases in micronuclei were detected up to toxic levels of the smoke. 4. The method used here could be applied to other pyrotechnic mixtures which give rise to complex mixtures of products.
British Industrial Biological Research Association, Carshalton, Surrey, UK.
S A
SA
Clode
R A
RA
Riley
S D
SD
Blowers
T C
TC
Marrs
D
D
Anderson
D000818:Animals; D001273:Atmosphere Exposure Chambers; D004980:Ethane / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests / Q000379:methods; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D012486:Salmonella typhimurium / Q000187:drug effects; D012906:Smoke / Q000009:adverse effects; D015034:Zinc Oxide / Q000633:toxicity*
D006843:Hydrocarbons, Chlorinated; D009153:Mutagens; D012906:Smoke; C010182:hexachloroethane; D004980:Ethane; D015034:Zinc Oxide