[The safety problem and a physiological strategy for using glucocorticoid hormones].
Principal problems of glucocorticoid hormone application in non-endocrine diseases are discussed proceeding from the mechanism of their action and the role in organism's life. It appeared that the hazard of glucocorticoid therapy is mainly due to the absence of a test for sufficiency and real needs in these hormones. It was shown that the test has to be introduced reflecting on the whole body level the glucocorticoid activity in the cell, that is similar to blood glucose in relation to insulin. The introduction of free blood tyrosine as such test appears to allow the development of safe individual strategy for the usage of glucocorticoids.
Piruzian
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Rass
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D005246:Feedback / Q000502:physiology; D005938:Glucocorticoids / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D006801:Humans; D010667:Phenylpyruvic Acids / Q000097:blood; D013312:Stress, Physiological / Q000097:blood; D014443:Tyrosine / Q000097:blood; D014444:Tyrosine Transaminase / Q000097:blood
D005938:Glucocorticoids; D010667:Phenylpyruvic Acids; C010590:4-hydroxyphenylpyruvic acid; D014443:Tyrosine; D014444:Tyrosine Transaminase
Problema bezopasnosti i fiziologicheskaia strategiia primeneniia gliukokortikoidnykh gormonov.