Serum granulocyte colony-stimulating factor levels in chronic neutropenia of infancy.
Eight infants with chronic neutropenia ranging in age from 1 to 13 months were studied for serum granulocyte colony-stimulating factor (G-CSF) levels. Serum G-CSF levels were elevated, especially when peripheral blood absolute neutrophil counts (ANC) were under 500/microliter in seven patients with autoimmune neutropenia. On the other hand, in a patient with congenital agranulocytosis (Kostmann type), G-CSF levels were below the sensitivity of the assay (less than 50 pg/ml) despite severe neutropenia (less than 100/microliter).
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Y
Y
Mizuno
T
T
Hara
M
M
Nagata
F
F
Omori
K
K
Shimoda
S
S
Okamura
Y
Y
Niho
K
K
Ueda
D001323:Autoantibodies / Q000032:analysis; D002908:Chronic Disease; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000097:blood*; D009504:Neutrophils / Q000276:immunology
D001323:Autoantibodies; D016179:Granulocyte Colony-Stimulating Factor