[Variations of the cardiac rhythm during drug treatment. Presuppositions of cardiac protection].
In the present study, the authors assessed the therapeutic efficacy of three drugs, each representing a different pharmacological class; i.e. indapamide as diuretic, doxazosin as alpha 1-blocker, and slow-release nifedipine as calcium blocker. The action of these drugs on blood pressure and on the reduction of both atrial and ventricular ectopic beats was observed taking into account the dynamic evolution of the heart as a result of increased blood pressure. This evolution goes from normal heart to hypertrophic and subsequently to dilated heart with attendant alterations of cardiac rhythm.
Falchetti
D
D
Reparto di Medicina, Ospedale di Lovere.
Bolandrina
E
E
Giardino
T
T
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D017292:Doxazosin; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007190:Indapamide / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D011224:Prazosin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000317:Adrenergic alpha-Antagonists; D007190:Indapamide; D009543:Nifedipine; D017292:Doxazosin; D011224:Prazosin
Variazioni del ritmo cardiaco durante trattamento farmacologico. Presupposti di cardioprotezione.