[An immunohistochemical investigation of estrogen receptor in human breast cancer].
An immunohistochemical investigation of 62 human breast Cancers has been conducted using two different monoclonal antibodies, ER-ICA and ER-D 5, for the demonstration of the estrogen receptor. ER-ICA was found to be positive in 28 cases (45.9%) whereas ER-D 5 was positive in 41 cases (68.3%). In 34 cases, the results were compared to results of a biochemical assay that employed dextran-coated charcoal. The overall concordance between the ER-ICA and the DCC was 78.8%, whereas ER-D 5 and DCC was 60.6%. We thus have concluded that ER-ICA is the more sensitive antibody for evaluating the estrogen receptor status in human breast cancer cases by this immunohistochemical analysis.
Dept. of Pathology, Jikei Univ. School of Med.
M
M
Hori
M
M
Furusato
S
S
Aizawa
H
H
Tanaka
K
K
Uchida
D000230:Adenocarcinoma / Q000378:metabolism; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism; D002293:Adenocarcinoma, Scirrhous / Q000378:metabolism; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D013194:Staining and Labeling
D011960:Receptors, Estrogen