[Palliative radiotherapy of brain metastases of solid tumors: experiences with high doses].
Results of palliative high dose irradiation in 145 patients with brain metastasis of various carcinomas are reported. All patients had whole brain irradiation by parallel opposed lateral fields with a midline dose of 13 to 14 x 300 cGy in 2,5 to three weeks. Patients with solitary brain metastasis received a local boost with 5 x 200 cGy. Twelve patients had also surgical excision of the brain metastasis. 39% of the patients had a marked improvement (good or very good neurological function class) and 30% had a moderate improvement. Neurologic function was stabilized in an improved state for 93% of the remaining survival time. This result corresponds to the observations of the RTOG in a randomized study of various doses, resulting in a standard dose of 10 x 300 cGy, but there is a small subgroup with a relatively favourable prognosis benefitting from surgery and irradiation or irradiation alone with a higher dose and conventional fractionation.
Klinik für Radiotherapie, Universitätsspital Zürich.
C
C
Glanzmann
D001932:Brain Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D010166:Palliative Care; D011379:Prognosis; D011879:Radiotherapy Dosage
Palliative Radiotherapie von Hirnmetastasen solider Tumoren: Erfahrungen mit hohen Dosen.