The interleukin-4 receptor gene (IL4R) maps to 16p11.2-16p12.1 in human and to the distal region of mouse chromosome 7.
The chromosomal location of both the human and the mouse interleukin-4 receptor (IL4R) genes have been determined. The human gene was localized to 16p11.2-16p12.1 by in situ hybridization and confirmed by Southern blot analysis of DNA from a panel of mouse-human hybrid somatic cell lines. The mouse homolog was positioned in the distal region of chromosome 7 by interspecific backcross analysis. The results suggest that the IL4R locus is unlinked to other members of the hematopoietin receptor family. Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas.
Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.
M A
MA
Pritchard
E
E
Baker
S A
SA
Whitmore
G R
GR
Sutherland
R L
RL
Idzerda
L S
LS
Park
D
D
Cosman
N A
NA
Jenkins
D J
DJ
Gilbert
N G
NG
Copeland
D000818:Animals; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D003433:Crosses, Genetic; D005260:Female; D015321:Gene Rearrangement; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D008080:Liposarcoma / Q000235:genetics; D008297:Male; D051379:Mice / Q000235:genetics*; D005810:Multigene Family; D009115:Muridae / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D019948:Receptors, Interleukin-4; D011975:Receptors, Mitogen / Q000235:genetics*; D013045:Species Specificity
D019948:Receptors, Interleukin-4; D011975:Receptors, Mitogen