Human memory T cells express intercellular adhesion molecule-1 which can be increased by interleukin 2 and interferon-gamma.
We have shown that low levels of intercellular adhesion molecule-1 (ICAM-1) expression can be detected on approximately 40% of the resting peripheral blood T cell population. The ICAM-1+ T cells have the phenotypic markers of memory cells which can be distinguished functionally from naive T cells by their ability to respond rapidly to previously experienced antigen. These cells appear to be in a state of marginal activation in that they also express low levels of the interleukin 2 receptor (Tac antigen) and have increased cell size as compared to the naive T cells. In addition we have shown that the cytokines interleukin 2 and interferon-gamma, both of which are products of activated T cells, are able to increase the expression of ICAM-1 on T cells. Finally, pretreating T cells with an anti-ICAM-1 monoclonal antibody inhibits their response to recall antigens, strongly suggesting a functional role for this protein on the memory T cell.
Macrophage Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London.
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AM
Buckle
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N
Hogg
D000943:Antigens, Differentiation / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001685:Biological Factors / Q000494:pharmacology; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002469:Cell Separation; D016207:Cytokines; D005434:Flow Cytometry; D006681:HLA-D Antigens / Q000032:analysis; D006801:Humans; D007156:Immunologic Memory; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma / Q000494:pharmacology*; D007376:Interleukin-2 / Q000494:pharmacology*; D008213:Lymphocyte Activation; D016169:Lymphocyte Function-Associated Antigen-1; D008562:Membrane Glycoproteins / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis; D016028:Receptors, Leukocyte-Adhesion / Q000032:analysis; D011990:Receptors, Transferrin / Q000032:analysis; D011994:Recombinant Proteins; D013601:T-Lymphocytes / Q000378:metabolism*
D000943:Antigens, Differentiation; D000954:Antigens, Surface; D001685:Biological Factors; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules; D016207:Cytokines; D006681:HLA-D Antigens; D007376:Interleukin-2; D016169:Lymphocyte Function-Associated Antigen-1; D008562:Membrane Glycoproteins; D015375:Receptors, Interleukin-2; D016028:Receptors, Leukocyte-Adhesion; D011990:Receptors, Transferrin; D011994:Recombinant Proteins; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma