Amplitude and latency characteristics of spinal cord motor evoked potentials in the rat.
The motor evoked potential (MEP) has become a valuable component of neurophysiological monitoring. A better understanding of the characteristics of the normal MEP is needed before one can fully appreciate the effects of injury on the MEP. We describe characteristic patterns of spinal cord MEPs, recorded epidurally, in response to transcranial (dura-to-palate) brain stimulation in a rat model. Series of signal averaged MEP responses at a duration of 100 microseconds were recorded at T10/11, T12/13, and L1/2 in 8 normal rats. We used a much greater range of current intensities (0.5-65 mA) than has been studied previously. Also, we studied the gradual development of the MEP wave form using smaller increments of current strength than have been reported previously. We confirmed in rats our earlier report in cats that long latency peaks appear first at low intensities while short latency peaks appear with higher intensities (Konrad et al. 1988). We also report average peak latencies over the range of stimulus intensities used for each recording level in each rat. In some rats, conduction velocities of several MEP peaks were calculated, and they range from 35 to 42 m/sec. These velocities are consistent with values reported in the literature for extrapyramidal pathways. Our rat model provides a method of measuring spinal cord potentials at three levels with no trauma to the spinal cord. Therefore, it can be used to repeatedly test motor function in chronic studies of spinal cord injury.
Dull
S T
ST
Indiana University School of Medicine.
Konrad
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PE
Tacker
W A
WA
D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000502:physiology; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D013116:Spinal Cord / Q000502:physiology*