[Expression of proliferation associated nuclear antigen P-105 in human gastric cancers: as a new marker for metastasis].
Expression of proliferation associated nuclear antigen P-105 was examined with flow cytometry in forty-three patients with advanced gastric cancer. Expression of P-105 was observed abundantly in cancer, about four times than normal mucosa, but little in normal gastric mucosa. We evaluated the expression of P-105 in cancer as P-105 intensity: mean FITC levels of G0G1 of the cancer cells/those of normal cells. The P-105 intensity did not correlate with DNA index or S-phase fraction. Furthermore, it did not correlate with histologic type, stromal type, infiltrating type, and gross appearance. However, P-105 intensity was significantly higher in the patients with hepatic metastasis, and lower in those with peritoneal dissemination than those without metastasis, respectively. From the results, it was supposed that P-105 intensity might be a useful indicator for metastatic type different from those previously reported in human gastric cancers.
Oyama
S
S
Second Department of Surgery, Kanazawa University School of Medicine, Japan.
Yonemura
Y
Y
Tsugawa
K
K
Kimura
Y
Y
Kamata
T
T
Miwa
K
K
Miyazaki
I
I
D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D005434:Flow Cytometry; D005753:Gastric Mucosa / Q000276:immunology; D006801:Humans; D009362:Neoplasm Metastasis; D009687:Nuclear Proteins / Q000032:analysis*; D018809:Proliferating Cell Nuclear Antigen; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen