In-vivo administration of recombinant IL-2 increases the number of Thy-1+ dendritic epidermal cells.
The number, morphology and response of Thy-1+ dendritic epidermal cells to recombinant interleukin-2 (rIL-2) were investigated in young and aged mice. The Thy-1+ dendritic cells in the aged mice continued to express T-cell receptor (TCR) gamma/delta but differed morphologically from those of the young mice. The aged mice had 50% fewer cells than the young ones. In the rIL-2 treated mice all the Thy-1+ cells were expressed as TCR gamma/delta and exposure to rIL-2 increased the number of these cells in a time- and dose-dependent manner when given systemically and locally. In the aged mice daily injection of rIL-2 increased the number of Thy-1+ dendritic cells within 2 weeks to almost that of young mice, however they had a lower response in the earlier stage. Nude mice showed no response to rIL-2.
Department of Dermatology, Yamanashi Medical College, Japan.
N
N
Shibagaki
K
K
Tamaki
S
S
Shimada
D000005:Abdomen; D000367:Age Factors; D000818:Animals; D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis*; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D004817:Epidermis / Q000187:drug effects*; D005260:Female; D005528:Foot; D007376:Interleukin-2 / Q000008:administration & dosage / Q000494:pharmacology*; D007518:Isoantibodies; D051379:Mice; D011994:Recombinant Proteins / Q000494:pharmacology; D018800:Thy-1 Antigens
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007376:Interleukin-2; D007518:Isoantibodies; D011994:Recombinant Proteins; D018800:Thy-1 Antigens; C035678:anti-Thy antibody