Soluble interleukin-2 receptors in children with Kawasaki syndrome.
We studied levels of soluble interleukin-2 receptors (IL-2R) in serial serum samples obtained from 93 patients with Kawasaki syndrome, using a double-antibody "sandwich" enzyme-linked immunosorbent assay technique. Concentrations of soluble IL-2R were significantly increased in Kawasaki syndrome patients in the first 4 weeks of illness when compared with either healthy adult or pediatric controls (P less than 0.02), and in the first 2 weeks of illness when compared with a group of children with measles (P less than 0.0001). Furthermore, in the second week of illness, levels of soluble IL-2R were significantly greater in children who subsequently developed coronary artery aneurysms than in patients with normal appearing coronary arteries. Serum concentration of soluble IL-2R is a useful marker for detecting early Kawasaki syndrome and identifies those patients who are at greater risk of developing coronary artery aneurysms.
Barron
K S
KS
Texas Children's Hospital, Houston 77030.
Montalvo
J F
JF
Joseph
A K
AK
Hilario
M O
MO
Saadeh
C
C
Giannini
E H
EH
Orson
F M
FM
D000328:Adult; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007154:Immune System Diseases / Q000503:physiopathology; D007275:Injections, Intravenous; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000276:immunology / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012995:Solubility; D005719:gamma-Globulins / Q000008:administration & dosage
D015375:Receptors, Interleukin-2; D005719:gamma-Globulins