The expression of human intercellular adhesion molecule-2 is refractory to inflammatory cytokines.
The beta 2-integrin CD11a/CD18 binds to the intercellular adhesion molecules (ICAM)-1 (CD54) and ICAM-2. ICAM-1 has a wide distribution, and its expression is up-regulated by various cytokines. In contrast, ICAM-2 has a more restricted distribution, and is mainly expressed on endothelial cells. In the present study we show that it is not induced by inflammatory cytokines or other treatments on any of several cells studied. Moreover, antibodies to the intercellular adhesion ligands were not able to block all CD11a/CD18-dependent adhesion, indicating the presence of additional CD11a/CD18 ligands.
Department of Biochemistry, University of Helsinki, Finland.
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Nortamo
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Li
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Renkonen
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Timonen
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Prieto
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Patarroyo
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Gahmberg
D015703:Antigens, CD; D015153:Blotting, Western; D000001:Calcimycin / Q000494:pharmacology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000503:physiopathology; D018799:Intercellular Adhesion Molecule-1; D007962:Leukocytes / Q000378:metabolism; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D016207:Cytokines; C065289:ICAM2 protein, human; D018799:Intercellular Adhesion Molecule-1; D015240:Phorbol 12,13-Dibutyrate; D000001:Calcimycin; D006427:Hemin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor