[Clinical evaluation of roxatidine acetate hydrochloride injection as preanesthetic medication].
The effects of single intravenous administration of roxatidine acetate hydrochloride 75 mg on the volume and pH of gastric juice were investigated in 43 patients undergoing elective surgery under general anesthesia. The drug was given 1 hour before anesthesia. The percentages of patients with gastric pH above 2.5 and gastric juice volume under 25 ml were 95.3% and 97.7% at the time of induction of anesthesia and at the time of extubation, respectively. As for overall assessment on gastric secretion, 93.0% was judged as very effective. In 2 cases, pricking sensations were observed at the time of injection, but these symptoms disappeared without any treatment within a few minutes. No other adverse reactions nor abnormal laboratory test findings were observed. In conclusion, roxatidine acetate hydrochloride administered intravenously 1 hour prior to anesthesia is thought to be useful to prevent acid aspiration pneumonitis.
Department of Anesthesiology, Fujita Health University Banbutane-Houtokukai Hospital, Nagoya.
M
M
Kawanishi
A
A
Enomoto
Y
Y
Shimada
Y
Y
Kurokawa
D000328:Adult; D005260:Female; D006635:Histamine H2 Antagonists; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines; D011015:Pneumonia, Aspiration / Q000517:prevention & control; D011229:Preanesthetic Medication
D006635:Histamine H2 Antagonists; D010880:Piperidines; C053742:roxatidine acetate