Antithrombin III and arterial disease.
Cross-sectional studies suggest that both low and high antithrombin III levels are associated with the risk of arterial disease, principally ischaemic heart disease (IHD). The prospective relation between antithrombin III and subsequent death from arterial disease has been investigated in 893 men in the Northwick Park Heart Study. Antithrombin III levels were directly correlated with high rather than low levels of factor VII activity and of plasma fibrinogen. There were more deaths from arterial disease in the low and high thirds of the antithrombin III distribution than in the middle third.
Meade
T W
TW
MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, UK.
Cooper
J
J
Miller
G J
GJ
Howarth
D J
DJ
Stirling
Y
Y
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood* / Q000401:mortality; D005167:Factor VII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015996:Survival Rate
D000990:Antithrombin III; D005167:Factor VII; D005340:Fibrinogen