Elevated sera levels of SP-1 induced by chemotherapy in patients with metastatic gestational trophoblastic diseases.
6 patients with invasive mole and 5 patients with choriocarcinoma were treated from 1983 till 1986. Serum samples were analyzed by simultaneous determining of pregnancy-specific beta-1-glycoprotein (SP-1) using enzyme-linked immunosorbent assay (ELISA) and beta subunit of human chorionic gonadotropin (beta-hCG) using Serono radioimmunoassay kit. In 2 patients with metastatic gestational trophoblastic disease (MGTD) SP-1 peaks were found during chemotherapy. In patients with MGTD with normalized beta-hCG levels a repeated, temporary elevation of isolated SP-1 levels was observed within some months following chemotherapy. After the last isolated peak of SP-1 the pulmonary metastases disappeared. This phenomenon was interpreted as a consequence of the oncolytic process in the affected tissue. In 1 patient with nonmetastatic choriocarcinoma SP-1 ELISA pseudoreaction was found. To recognize these pseudoreactions, a control plate with nonimmunized rabbit IgG was used, simultaneously with SP-1 determinations.
Department of Obstetrics and Gynecology, University Medical School, Pécs, Hungary.
P M
PM
Göcze
G N
GN
Than
D G
DG
Szabò
I F
IF
Csaba
H
H
Bohn
D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D002822:Choriocarcinoma / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D006063:Chorionic Gonadotropin / Q000097:blood / Q000652:urine; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D002820:Hydatidiform Mole, Invasive / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D010446:Peptide Fragments / Q000097:blood; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D012016:Reference Values; D014594:Uterine Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000473:pathology
D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D011268:Pregnancy-Specific beta 1-Glycoproteins