Erythropoietin and spontaneous platelet aggregation in haemodialysis patients.
Erythropoietin significantly, reversibly, and reproducibly increased in-vitro whole-blood spontaneous platelet aggregation in 15 patients on haemodialysis. During erythropoietin treatment, spontaneous platelet aggregation was significantly higher in these subjects than in non-uraemic controls; concomitant treatment with 300 mg aspirin daily reversed platelet hyperaggregability. Erythropoietin may promote thrombosis by an effect on platelet function.
Taylor
J E
JE
Renal Unit, Ninewells Hospital and Medical School, Dundee, UK.
Henderson
I S
IS
Stewart
W K
WK
Belch
J J
JJ
D000740:Anemia / Q000188:drug therapy / Q000209:etiology; D001241:Aspirin / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D004176:Dipyridamole / Q000494:pharmacology; D004921:Erythropoietin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D010974:Platelet Aggregation / Q000187:drug effects*; D006435:Renal Dialysis
D004921:Erythropoietin; D004176:Dipyridamole; D001241:Aspirin