Combination of atipamezole and tetrahydroaminoacridine/pilocarpine treatment suppresses high voltage spindle activity in aged rats.
The present study evaluated the effects of combined alpha2-antagonist (atipamezole) and anticholinesterase (tetrahydroaminoacridine, THA) or muscarinic agonist (pilocarpine) treatments on the high voltage spindle (HVS) activity in aged rats. On their own, high doses of THA (3 mg/kg), pilocarpine (3 mg/kg) and atipamezole (3 mg/kg) suppressed HVS activity. Low doses of THA (1 mg/kg), pilocarpine (1 mg/kg) and atipamezole (1 mg/kg) did not suppress HVS activity. Combinations of low doses of atipamezole and THA or pilocarpine suppressed HVS activity. Our results suggest that 1) the administration of alpha2-antagonist blocked the age-related deficit of thalamocortical activation, 2) a combination of alpha2-antagonist and a cholinergic drug may more effectively stabilize age-related HVS activity than either of the treatments alone.
Riekkinen
P
P
Department of Neurology, University of Kuopio, Finland.
Riekkinen
M
M
Jäkälä
P
P
Sirvioö
J
J
Lammintausta
R
R
Riekkinen
P
P
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000375:Aging / Q000502:physiology*; D000818:Animals; D004338:Drug Combinations; D004594:Electrophysiology; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D009470:Muscle Spindles / Q000187:drug effects* / Q000502:physiology; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time; D013619:Tacrine / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D004338:Drug Combinations; D007093:Imidazoles; D010862:Pilocarpine; C050701:atipamezole; D013619:Tacrine