The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB.
Cytogenetic studies and DNA analysis have shown that the short arm of chromosome 3 is the region in the genome that is commonly deleted in renal cell carcinoma. By studying loss of heterozygosity in 41 matched tumor/normal kidney tissue pairs, we could delimit the commonly deleted part of 3p to the region between the loci THRB (in 3p24) and D3S2 (in 3p21). The regions on 3p suggested to be involved in the Von Hippel-Lindau syndrome and in hereditary renal cell carcinoma are both outside this smallest region of overlapping deletions. Consequently, renal cell cancer would be an illustration of the possibility that different genes cause the same type of tumor.
Department of Medical Genetics, University of Groningen, The Netherlands.
A H
AH
van der Hout
P
P
van der Vlies
C
C
Wijmenga
F P
FP
Li
J W
JW
Oosterhuis
C H
CH
Buys
D000483:Alleles; D015139:Blotting, Southern; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D015342:DNA Probes / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D006623:von Hippel-Lindau Disease / Q000235:genetics
D015342:DNA Probes; D004273:DNA, Neoplasm