Transplantation resistance to a murine plasmacytoma lacking MHC determinants.
A spontaneously arising murine plasmacytoma, HPC-202, derived from a BALB/c.H-2b congenic mouse that lacks any detectable H-2 determinants on its cell surface is described. However, the expression of H-2 determinants is inducible by interferon-gamma. The H-2 negative cell surface phenotype permits the HPC-202 tumor to escape H-2 allospecific cytotoxic cell lysis but not NK cell lysis, as well as to grow, to varying degrees, in some H-2 incompatible hosts. In those strains which exhibit a resistance to HPC-202 growth, resistance does not map to a single gene within the major histocompatibility complex of the mouse. Resistance is also radiosensitive and is therefore presumably due to a rapidly dividing cell population. The utility of this tumor as a model system to study both the non-H-2-restricted natural resistance to tumor growth, and the mechanism by which H-2 genes are regulated by cells is discussed.
Department of Pathology, University of New Mexico School of Medicine, Albuquerque 87131.
M J
MJ
Daley
T J
TJ
Williams
J
J
Giorgi
N L
NL
Warner
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D000939:Epitopes / Q000032:analysis*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005805:Genes, MHC Class I / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D006087:Graft vs Host Reaction / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D010641:Phenotype; D010954:Plasmacytoma / Q000276:immunology* / Q000473:pathology; D011836:Radiation Tolerance / Q000235:genetics / Q000276:immunology; D014181:Transplantation Immunology / Q000276:immunology*; D014407:Tumor Cells, Cultured / Q000276:immunology
D000954:Antigens, Surface; D000939:Epitopes