Hyperplasia of somatostatin and pancreatic polypeptide immunoreactive cells in dogs with idiopathic atrophy of the exocrine pancreas.
The pancreatic tissue from 25 dogs with idiopathic atrophy of the exocrine pancreas, and from 6 control dogs, was studied histologically and immunohistometrically. Cells producing insulin (B), glucagon (A), somatostatin (D), and pancreatic polypeptide (PP) were identified using specific antisera and the ABC technique. Histometrical quantitation revealed differences in the distribution of these cell types between the right and left pancreatic lobe. Initial stages of atrophy showed little changes concerning the relative proportions of the four cell types examined. In more advanced stages of atrophy, however, there was significant increase in the percentage of the D cells in the cell population of the left lobe. B and A cells showed no significant changes. In final stages, only tiny tissue spots were considered a secondary and regenerative phenomenon, but an endocrine dysregulation cannot be excluded. Atrophy accompanied by diabetes mellitus and a lack of B cells seem to be due to a deficiency of insulin.
Institute of Veterinary Pathology, Freie Universität Berlin.
J
J
Hellmann
H
H
Loppnow
D000818:Animals; D001284:Atrophy; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D006965:Hyperplasia; D010179:Pancreas / Q000473:pathology*; D010182:Pancreatic Diseases / Q000473:pathology / Q000662:veterinary*; D010191:Pancreatic Polypeptide / Q000096:biosynthesis*; D013004:Somatostatin / Q000096:biosynthesis*
D013004:Somatostatin; D010191:Pancreatic Polypeptide