[A possible role of phosphoprotein p53 in the mechanism of autostimulation of tumor cell proliferation].
It has been shown that phosphoprotein p53 may participate in the DNA-synthesis stimulation in the mixed culture of tumour cells and syngeneic embryonic mouse cells (10 days of pregnancy). This effect has been eliminated by the preliminary treatment of embryonic cells in vitro by the monoclonal antibodies to p53 (pAb421) in the model system. A conclusion is drawn that p53-epitopes of embryonic cell surface membrane take part in the formation of the determinant which is recognized by receptors of tumour cells. The stimulation of DNA-synthesis in tumour cells is resulted by this process.
Ageenko
A I
AI
Erkhov
V S
VS
Cherniaev
L V
LV
Volkova
L Iu
LIu
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D002455:Cell Division; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004622:Embryo, Mammalian; D000939:Epitopes; D005260:Female; D051379:Mice; D008811:Mice, Inbred DBA; D009687:Nuclear Proteins / Q000502:physiology*; D015513:Oncogene Proteins / Q000502:physiology*; D010750:Phosphoproteins / Q000502:physiology*; D011247:Pregnancy; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53
D000911:Antibodies, Monoclonal; D004273:DNA, Neoplasm; D000939:Epitopes; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D010750:Phosphoproteins; D016159:Tumor Suppressor Protein p53
Vozmozhnaia rol' fosfobelka p53 v mekhanizme autostimuliatsii proliferatsii opukholevykh kletok.