Naturally occurring IgG-antibody-like substance reacting with quaternary ammonium group and neuromuscular blockers: a common finding in humans and other species?
IgG antibodies reacting with the quaternary ammonium group of choline and alcuronium appeared to be present in the sera of humans, guinea pigs, and rats. The antibodies, particularly those 'against' alcuronium, were detected in every serum by paper immunosorbent test(s). This finding, if substantiated, would be of fundamental importance in view of the wide distribution of choline derivatives within the body and in the environment. It may also be relevant to the histamine-releasing activity of neuromuscular blockers and compounds possessing the quaternary ammonium group.
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Department of Pharmacology, University College, London, UK.
D000443:Alcuronium / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D002794:Choline / Q000276:immunology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D006967:Hypersensitivity / Q000097:blood; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology*; D009466:Neuromuscular Blocking Agents / Q000276:immunology*; D000644:Quaternary Ammonium Compounds / Q000276:immunology*; D011852:Radioallergosorbent Test; D051381:Rats; D011919:Rats, Inbred Strains; D013390:Succinylcholine / Q000276:immunology
D007074:Immunoglobulin G; D009466:Neuromuscular Blocking Agents; D000644:Quaternary Ammonium Compounds; D007073:Immunoglobulin E; D013390:Succinylcholine; D002794:Choline; D000443:Alcuronium