[The role of the system of proteolytic enzymes and their inhibitors in the pathogenesis of ovarian tumors in Wistar rats and the possibilities for correcting the disorders detected].
The system of proteolytic enzymes and their inhibitors was studied in tissues of ovarian tumours of Wistar rats. It has been revealed that activation of proteolysis enzymes is observed in the genesis of tumour growth against a background of the absence of protease inhibitors. The correction of revealed disturbances by introducing the inhibitors of proteolytic enzymes and hormone preparations has shown that contrical and norcolute are the most effective. The results obtained suggest the further search of preparation normalizing the condition of the given system.
V N
VN
Zaporozhan
N I
NI
Shchurko
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D007611:Aprotinin / Q000008:administration & dosage; D002715:Chlormadinone Acetate / Q000008:administration & dosage; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D004338:Drug Combinations; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006106:Granulosa Cell Tumor / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology; D009368:Neoplasm Transplantation; D009640:Norethindrone / Q000008:administration & dosage; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology*; D010052:Ovariectomy; D010447:Peptide Hydrolases / Q000378:metabolism*; D011480:Protease Inhibitors / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013798:Thecoma / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology
D000970:Antineoplastic Agents; D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D011480:Protease Inhibitors; D002715:Chlormadinone Acetate; C010260:Non-Ovlon; D007611:Aprotinin; D010447:Peptide Hydrolases; D009640:Norethindrone
Rol' sistemy proteoliticheskikh fermentov i ikh ingibitorov v patogeneze opukholeĭ iaichnika u krys Wistar i vozmozhnosti korrektsii vyiavlennykh narusheniĭ.