[Augmentation of antitumor immunity in cancer chemotherapy].
Cancer chemotherapeutic drugs (antitumor drugs) generally inhibit host immune responses to cancer cells. Some antitumor drugs, however, can augment antitumor immune responses if they were administered appropriately. The immuno-augmentation brought about by antitumor drugs might concrete the effects of cancer chemotherapy. The authors introduced their experiments in which they have observed a typical BRM-like effects of bleomycin on tumor-bearing rats and discussed the significance of immuno-augmenting effects of antitumor drugs in cancer chemotherapy.
Hosokawa
M
M
Cancer Institute, Hokkaido University School of Medicine.
Kobayashi
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D007155:Immunologic Factors / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology; D051381:Rats
D000970:Antineoplastic Agents; D007155:Immunologic Factors; D001761:Bleomycin; D003520:Cyclophosphamide