Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations.
Corticotropin releasing hormone (CRH), somatostatin (SRIF), and arginine vasopressin (AVP) concentrations were estimated using radioimmunoassay in the temporal and occipital cortices in postmortem brain from patients clinically and neuropathologically diagnosed as senile dementia of the Lewy body type (SDLT), senile dementia of the Alzheimer type (SDAT), and Parkinson's disease (PD) and from neurologically normal controls. The concentration of temporal and occipital neocortical CRH was diminished in both SDAT and SDLT compared to control values, whereas SRIF was reduced only in temporal cortex in both these conditions. In contrast, the concentrations of both CRH and SRIF were unaltered in PD. The concentrations of AVP in SDLT, SDAT, and PD were similar to those found in the control groups. The decrement in SRIF, but not CRH, was found to be correlated with some indices of severity of illness in SDAT; a similar but nonsignificant trend for SRIF was observed in SDLT.
MRC Neurochemical Pathology Unit, Newcastle General Hospital, UK.
A
A
Leake
E K
EK
Perry
R H
RH
Perry
S
S
Jabeen
A F
AF
Fairbairn
I G
IG
McKeith
I N
IN
Ferrier
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000523:psychology; D001127:Arginine Vasopressin / Q000378:metabolism; D002540:Cerebral Cortex / Q000473:pathology; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D003704:Dementia / Q000473:pathology* / Q000523:psychology; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000648:ultrastructure*; D008297:Male; D009454:Neurofibrils / Q000648:ultrastructure; D009479:Neuropeptides / Q000378:metabolism*; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology* / Q000523:psychology; D013004:Somatostatin / Q000378:metabolism; D013702:Temporal Lobe / Q000473:pathology
D009479:Neuropeptides; D001127:Arginine Vasopressin; D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone