Different effects of chlorpromazine on bleomycin- and epirubicin induced cytotoxicity.
The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.
Department of Clinical Chemistry, Umeå University Hospital, Sweden.
K
K
Grankvist
P
P
Bergström
R
R
Henriksson
D001761:Bleomycin / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003603:Cytotoxins; D015251:Epirubicin / Q000494:pharmacology*; D005347:Fibroblasts
D003603:Cytotoxins; D001761:Bleomycin; D015251:Epirubicin; D002746:Chlorpromazine