[Striato-nigral degeneration (SND): a multisystem atrophy?].
Two cases of striato-nigral degeneration are reported. In case 1 the female patient showed a Parkinson syndrome, cardiac arrhythmias and vasomotor disturbances. Morphologically mainly the putamen and substantia nigra revealed severe atrophic changes according to the restricted form of striato-nigral degeneration (SND). In case 2 there was a disorder of the upper and lower motor neuron in a female patient. Morphologically this case was an example of a multisystem atrophy with changes in the striato-nigral, olivo-ponto-cerebellar systems and spinal motor and autonomic neurons. These cases demonstrate the variability of the striato-nigral degenerations which are met with in two forms: a "pure" form as in case one and as a part of multisystem atrophies. This is underlined in a review of 69 literature cases, which also shows that SND, Shy-Drager syndrome and olivo-ponto-cerebellar atrophy represent very probably different varieties of one and the same degenerative process.
Bergmann
M
M
Institut für Neuropathologie, Universität Münster.
Schmidtke
K
K
Danek
A
A
Gullotta
F
F
Mehraein
P
P
D000368:Aged; D002421:Caudate Nucleus / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology*; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology*; D009474:Neurons / Q000473:pathology; D009849:Olivopontocerebellar Atrophies / Q000473:pathology; D010302:Parkinson Disease, Secondary / Q000473:pathology*; D011699:Putamen / Q000473:pathology; D013132:Spinocerebellar Degenerations / Q000473:pathology; D013378:Substantia Nigra / Q000473:pathology*; D013787:Thalamic Nuclei / Q000473:pathology
Striato-nigrale Degeneration (SND): eine Multisystematrophie?