Normal B cell compartment in chronic lymphatic leukemia.
In contrast to normal B lymphocytes, CLL cells express CD5 antigen believed to be a T cell marker. We have assessed normal and malignant B cell compartments in CLL patients with the aid of two-colour immunofluorescence techniques (CD5-TRITC, DR-FITC). No clear correlation was found between progression of disease and parameters studied. However, there was a tendency for a diminution of normal B cells in advanced stages of disease.
Pluta
A
A
Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
Górski
A
A
Nowaczyk
M
M
Modlińska
M
M
D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D018951:Antigens, CD20; D000943:Antigens, Differentiation / Q000032:analysis*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens; D005260:Female; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D018951:Antigens, CD20; D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D018956:CD5 Antigens