Effect of cyclosporine A and oligomycin on non-specific permeability of the inner mitochondrial membrane.
The effect of oligomycin and cyclosporine A on the induction of non-specific permeability of the inner mitochondrial membrane by Ca2+ was under study. Both oligomycin and cyclosporine A were able to prevent the activation of non-specific permeability, but cyclosporine A was the only agent which could restore initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was shown not to be mediated through redistribution of Ca2+ between different mitochondrial subpopulations.
A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Department of Biophysics, M.V. Lomonosov Moscow State University, USSR.
S A
SA
Novgorodov
T I
TI
Gudz
Y E
YE
Kushnareva
D B
DB
Zorov
Y B
YB
Kudrjashov
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology*; D004533:Egtazic Acid; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000187:drug effects*; D009840:Oligomycins / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D010710:Phosphates / Q000494:pharmacology; D051381:Rats; D012430:Ruthenium Red
D003524:Cyclosporins; D009840:Oligomycins; D010710:Phosphates; D012430:Ruthenium Red; D004533:Egtazic Acid; D002118:Calcium