HLA-Bw54-DR4-DRw53-DQw4 haplotype controls nonresponsiveness to hepatitis-B surface antigen via CD8-positive suppressor T cells.
We have previously reported that in nonresponders to hepatitis-B (HB) vaccine there was an HLA-linked immune suppression gene for hepatitis-B surface antigen (Is-HBsAg) controlling the nonresponsiveness to HBsAg, through HBsAg-specific suppressor T cells, and that the Is-HBsAg was in strong linkage disequilibrium with the HLA-Bw54-DR4-DRw53 haplotype (1). We have now done the HLA typing on an additional 6 nonresponders, and using the system of T-cell proliferative response to HBsAg we found that the Is-HBsAg controlled the nonresponsiveness to HBsAg through HBsAg-specific suppressor T cells in nonresponders to HB vaccine who have HLA-Bw54-DR4-DRw53-DQw4 haplotype. T- and B-cell recognition of HB vaccines might play an important role at 3 to 5 weeks after the last immunization. Use of an anti-HLA monoclonal antibody has shown that the HLA-DR molecule plays an important role in helper T-cell proliferation in nonresponders, although the role of HLA-DQ molecule in nonresponders was unclear.
First Department of Internal Medicine, School of Medicine, Fukuoka University, Japan.
H
H
Watanabe
M
M
Okumura
K
K
Hirayama
T
T
Sasazuki
D000911:Antibodies, Monoclonal; D000939:Epitopes / Q000276:immunology; D015235:HLA-B Antigens / Q000502:physiology*; D006681:HLA-D Antigens / Q000502:physiology*; D006683:HLA-DQ Antigens / Q000502:physiology; D006684:HLA-DR Antigens / Q000502:physiology; D015804:HLA-DR4 Antigen / Q000502:physiology; D059845:HLA-DRB4 Chains; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines; D006650:Histocompatibility Testing; D006801:Humans; D007114:Immunization; D008213:Lymphocyte Activation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology; D014761:Viral Hepatitis Vaccines / Q000276:immunology
D000911:Antibodies, Monoclonal; D000939:Epitopes; D015235:HLA-B Antigens; C113783:HLA-B54 antigen; D006681:HLA-D Antigens; D006683:HLA-DQ Antigens; C060029:HLA-DQ4 antigen; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; C050610:HLA-DR53; D059845:HLA-DRB4 Chains; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic; D014761:Viral Hepatitis Vaccines