Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin.
A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of 3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress.
Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia.
I M
IM
McIntyre
T R
TR
Norman
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007211:Indoles / Q000494:pharmacology*; D007510:Isatin / Q000494:pharmacology*; D007650:Ketanserin / Q000378:metabolism; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism* / Q000493:pharmacokinetics; D013574:Synaptosomes / Q000378:metabolism
D007211:Indoles; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D007510:Isatin; C039776:tribulin; D007650:Ketanserin