[Damage to the structure of DNA and to the metabolism of nucleic acids in the thymus in relation to the dose of tritium oxide].
Single administration of tritium oxide (1.1-44 MBq per 1 kg of body mass) causes a dose-dependent decrease in the level of rat thymus nucleic acids within the range of concentrations of injected tritium 5.5-44 MBq/g. Biosynthesis of nucleic acids turned out to be more sensitive to tritium oxide action. The rate of biosynthesis changed on the 1st day at the lowest dose of 1.1 MBq/g, the absorbed dose on the 1st day was 7.5 cGy. Dose-dependent disorders of DNA structure in the content of 2-strand DNA after the administration of tritium oxide (9-44 MBq/g) were established.
Shorokhova
V B
VB
Rusinova
G G
GG
Mushkacheva
G S
GS
D000818:Animals; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D008297:Male; D012313:RNA / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*; D014316:Tritium / Q000008:administration & dosage*; D014867:Water / Q000008:administration & dosage*
D014867:Water; D014316:Tritium; C033961:tritium oxide; D012313:RNA; D004247:DNA
Povrezhdenie struktury DNK i metabolizma nukleinovykh kislot timusa v zavisimosti ot dozy okisi tritiia.