Hydroxyethyl starch pretreatment in bacteremic sheep.
Live bacteria were infused in a chronic ovine lung lymph model to determine if a preceding infusion of the colloid, hydroxyethyl starch (HES), exaggerated the cardiopulmonary dysfunction or impaired removal of bacteria by macrophages in the pulmonary circulation. HES was infused (3 mL/kg/hr; n = 6) from 24 to 12 hr before the bacteria and decreased plasma protein content and increased pulmonary lymph to plasma protein concentration because of its oncotic properties. Ringer's lactate (2 mL/kg/hr) was given after stopping HES and also to the control group (n = 6). Infusion of live Ps. aeruginosa (2.5 x 10(8) Ps./min for approximately 30 min) induced equivalent pulmonary hypertension, increased pulmonary microvascular permeability, and cardiovascular depression in the two groups. The removal of bacteria in the lungs was not affected, indicating that this measurement of the function of the mononuclear phagocytic system was not impaired by the preceding HES.
Lübbesmeyer
H J
HJ
Department of Anesthesiology, University of Texas Medical Branch 77550.
Dehring
D J
DJ
Theissen
J L
JL
Fleming
D
D
Traber
L
L
Herndon
D N
DN
Traber
D L
DL
D000818:Animals; D003114:Colony-Forming Units Assay; D005260:Female; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D011292:Premedication; D011552:Pseudomonas Infections / Q000503:physiopathology / Q000628:therapy*; D011669:Pulmonary Wedge Pressure; D018805:Sepsis / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D012756:Sheep
D006895:Hydroxyethyl Starch Derivatives