Interferon activity is not detected in blastocyst secretions and does not induce decidualization in mice.
Mouse trophoblast cells synthesized and secreted proteins during the peri-implantation period, some in the molecular size range of alpha interferons (IFN-alpha), known mediators of the maternal recognition of pregnancy in sheep and cows. However, conditioned media samples containing secreted proteins from Day-5 mouse blastocysts or from trophoblast outgrowths did not contain detectable levels of antiviral activity indicative of IFN. In addition, it was not possible to induce a decidual reaction in suitably sensitized uteri with intraluminal instillation of IFN-alpha. The results indicate that IFNs are probably not involved in the maternal recognition of pregnancy at the time of implantation in the mouse.
Department of Anatomy, Wright State University School of Medicine Dayton, Ohio 45435.
D J
DJ
Baker
G L
GL
Nieder
D000818:Animals; D003656:Decidua / Q000502:physiology*; D005260:Female; D007370:Interferon Type I / Q000494:pharmacology; D007372:Interferons / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011506:Proteins / Q000378:metabolism; D014327:Trophoblasts / Q000166:cytology / Q000502:physiology*; D014599:Uterus / Q000502:physiology
D007370:Interferon Type I; D011506:Proteins; D007372:Interferons