Synthesis and pharmacological study of a thiophene analogue of moprolol and related compounds.
The syntheses of the thiophenic analogue of Moprolol (1d) and of its related compound 1a are described. From a preliminary pharmacological evaluation compound 1d seems worthy of further studies due to its notable beta-blocking activity and its remarkable anti-platelet aggregation action.
Instituto de Quimica Médica, Madrid, Spain.
M B
MB
el-Ashmawy
J
J
Lissavetzky
V
V
Darias
D
D
Martín-Herrera
D000319:Adrenergic beta-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D050198:Phenoxypropanolamines; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity
D000319:Adrenergic beta-Antagonists; D050198:Phenoxypropanolamines; D010975:Platelet Aggregation Inhibitors; D011412:Propanolamines; D013876:Thiophenes; C009976:moprolol