Identification of insulin-like growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight IGF-BP in human seminal plasma.
Three distinct binding proteins for the insulin-like growth factors (IGF-BPs) have recently had their cDNAs cloned and sequenced. We have evaluated IGF-BP expression in normal, oligospermic and azospermic human seminal plasma (SP), and have identified IGF-BP-2 in all samples. Additionally, SP contains a non-glycosylated low molecular weight IGF-BP (24K), which does not appear to be structurally or immunologically related to IGF-BP-1, -2 or -3.
Department of Pediatrics, Stanford University Medical Center, California 94305.
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Rosenfeld
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Pham
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Lamson
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Giudice
D001483:Base Sequence; D015153:Blotting, Western; D002352:Carrier Proteins / Q000032:analysis* / Q000235:genetics; D003001:Cloning, Molecular; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D008297:Male; D008970:Molecular Weight; D009845:Oligospermia / Q000097:blood / Q000378:metabolism*; D012661:Semen / Q000032:analysis*
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins