CD4+ T cells regulate the magnitude of the antibody response to several helper T cell independent antigens.
The effect of prior depletion of CD4+ T cells on the magnitude of the primary antibody response to several antigens considered to be helper T cell independent (TI) was examined. Treatment of mice with the monoclonal antibody GK1.5 to remove CD4+ T cells had little effect on the magnitude of the specific antibody response to the lipopolysaccharide (LPS) of Escherichia coli 0113; however, such treatment reduced the magnitude of the splenic IgM antibody response to E. coli 055 LPS, Serratia marcescens LPS, TNP-Ficoll, and Type III pneumococcal polysaccharide (SSS-III), compared to control untreated or rat IgG treated mice. Thus, CD4+ T cells positively influence of magnitude of the antibody response to the majority of helper T cell independent antigens tested.
Department of Cellular Immunology, Walter Reed Army Institute of Research, Rockville, Maryland.
K L
KL
Elkins
R M
RM
Buller
P W
PW
Stashak
P J
PJ
Baker
D000818:Animals; D000917:Antibody Formation; D015703:Antigens, CD / Q000276:immunology*; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology*; D000955:Antigens, T-Independent / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011135:Polysaccharides, Bacterial / Q000276:immunology; D012706:Serratia marcescens / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000955:Antigens, T-Independent; D008070:Lipopolysaccharides; D011135:Polysaccharides, Bacterial; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C026604:pneumococcal polysaccharide, type III