[Indices of lipid peroxidation in the condensate of exhaled air--a simple and objective method of estimating injuries to the pulmonary surfactant system].
A method for assessing injury to the pulmonary surfactant system is suggested, based on studies of lipid peroxidation parameters in exhaled air condensate. Free-radical processes in pulmonary surfactants were examined in normal subjects and in patients with various forms of chronic nonspecific diseases of the respiratory organs. The findings evidence that a disease essentially intensifies lipid peroxidation in the alveolar lining, this being parallelled by reduced antiradical defense. Such an approach to studies of pulmonary surfactant system injuries is marked for its simplicity and atraumatism, this recommending it for mass clinical check-ups. Use of this method is promising as regards the disease prognosis and assessment of the treatment efficacy, as well as detection of subjects at high risk of developing bronchopulmonary diseases.
B S
BS
Khyshiktuev
V N
VN
Ivanov
N V
NV
Solov'eva
M Z
MZ
Zhits
D000328:Adult; D000368:Aged; D001944:Breath Tests; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008171:Lung Diseases / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011663:Pulmonary Surfactants / Q000502:physiology*
D011663:Pulmonary Surfactants
Pokazateli perekisnogo okisleniia lipidov v kondensate vydykhaemogo vozdukha--prostoĭ i ob"ektivnyĭ metod otsenki povrezhdeniĭ v surfaktantnoĭ sisteme legkikh.