Ornithine aminotransferase-related sequences map to two nonadjacent intervals on the human X chromosome short arm.
Using a panel of human/rodent somatic cell hybrids segregating human X/autosome translocations and deletions, we have refined the localization of the X-linked sequences homologous to ornithine-delta-aminotransferase (OAT), the structural locus for which (OAT) maps to chromosome 10. OAT-related ("-like") (OATL) sequences mapped to two nonadjacent intervals: OATL1 mapped to Xp11.3-p11.23, while OATL2 mapped to Xp11.22-p11.21. X-linked OATL1 sequences polymorphic for ScaI and StuI map to the more distal interval in Xp11.3-p11.23. These results should help guide long-range cloning and mapping studies, as well as refine the genetic linkage map in this region of the X chromosome.
Lafreniere
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RG
Department of Genetics, Stanford University, California 94305.
Geraghty
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MT
Valle
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Shows
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TB
Willard
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HF
D000818:Animals; D015139:Blotting, Southern; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009953:Ornithine-Oxo-Acid Transaminase / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014960:X Chromosome
D009953:Ornithine-Oxo-Acid Transaminase