The nephrotoxicity of 2,5-dichloro-3-(glutathion-S-yl)-1,4-benzoquinone, and 2,5,6-trichloro-3-(glutathion-S-yl)-1,4-benzoquinone is potentiated by ascorbic acid and AT-125.
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin.
T J
TJ
Monks
S S
SS
Lau
J J
JJ
Mertens
J H
JH
Temmink
P J
PJ
van Bladeren
D000818:Animals; D001205:Ascorbic Acid / Q000633:toxicity; D001806:Blood Urea Nitrogen; D002703:Chloranil / Q000031:analogs & derivatives* / Q000633:toxicity; D004357:Drug Synergism; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D007555:Isoxazoles / Q000633:toxicity; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D007555:Isoxazoles; D002703:Chloranil; C057105:2-gluthionyl-3,5,6-trichloro-1,4-benzoquinone; C069711:2,5-dichloro-3-(glutathionyl-S-yl)-1,4-benzoquinone; D005723:gamma-Glutamyltransferase; D005978:Glutathione; C006303:acivicin; D001205:Ascorbic Acid