The cystic fibrosis gene: isolation and significance.
The identification and cloning of the CF gene, which codes for a membrane protein that appears to regulate transmembrane ion transport, may lead to an understanding of the basic defect in the disease and to more effective treatment. More broadly, the cloning of the CF gene provides a fast start in the international effort to clone and map the entire human genome.
Collins
F S
FS
University of Michigan.
Riordan
J R
JR
Tsui
L C
LC
D016386:Chromosome Walking; D003001:Cloning, Molecular / Q000379:methods; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000235:genetics*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D005260:Female; D005796:Genes / Q000235:genetics; D006580:Genetic Carrier Screening; D008040:Genetic Linkage / Q000235:genetics; D015316:Genetic Therapy; D016045:Human Genome Project; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D012107:Research Design
C505032:CFTR protein, human; D008565:Membrane Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator