Autoimmune thrombocytopenia in pediatric systemic lupus erythematosus: alternative therapeutic modalities.
Three patients with pediatric systemic lupus erythematosus (PSLE) and autoimmune thrombocytopenia (AT), who developed unacceptable side effects (pseudotumor cerebri, hypertension, excessive weight gain) from treatment with steroids, were treated successfully with vincristine (2 patients) or intravenous immunoglobulin (1 patient). All patients remained off steroids without any complications for 11 to 23 months.
Department of Pediatrics, George Washington University Medical School, Washington, D.C. 20010.
R N
RN
Lipnick
G C
GC
Tsokos
G L
GL
Bray
P H
PH
White
D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology*; D002648:Child; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007262:Infusions, Intravenous; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D010976:Platelet Count / Q000187:drug effects; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011559:Pseudotumor Cerebri / Q000139:chemically induced; D011696:Purpura, Thrombocytopenic / Q000188:drug therapy / Q000209:etiology*; D012008:Recurrence; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects; D005719:gamma-Globulins / Q000008:administration & dosage / Q000627:therapeutic use
D005719:gamma-Globulins; D014750:Vincristine; D011241:Prednisone