Coupling daunorubicin to monoclonal antialphafoetoprotein with a new activated derivative.
We report the synthesis of daunorubicin antialphafoetoprotein conjugates, using a new coupling method. At equimolar concentrations on AFP producing cells in vitro, these conjugates were found three times as cytotoxic as the free drug.
Thibeault
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Department of Biochemistry, Faculty of Medicine, Université Laval, Sainte-Foy, Québec, Canada.
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D000818:Animals; D000911:Antibodies, Monoclonal; D002470:Cell Survival / Q000187:drug effects; D003630:Daunorubicin / Q000627:therapeutic use*; D004347:Drug Interactions; D005976:Glutaral / Q000494:pharmacology; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D014407:Tumor Cells, Cultured; D000509:alpha-Fetoproteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D000509:alpha-Fetoproteins; D005976:Glutaral; D003630:Daunorubicin