Administered dose and tumor dose of bleomycin labeled with cobalt-57 in mice and men.
Tumor concentrations of the chemotherapeutic drug, bleomycin, labeled with cobalt-57 (Co-bleo) were compared in mouse tumor models and in human lung tumors using quantitative single-photon emission computed tomography. Drug concentrations in histologically similar human tumors showed marked variability for the same injected dose (ID). Small cell carcinomas showed concentrations between 1.09 and 8.85 %ID/cc x 10(-3) while non-small cell lung tumors showed a concentration variation between 0.36 and 6.75 %ID/cc x 10(-3). In contrast to the situation in human tumors, uptake in mouse tumors showed only slight variability in animals with the same tumor model. EMT-6 tumors in mice showed at 6 hr significantly higher uptake of Co-bleo (p less than 0.001) and significantly higher tumor-to-lung ratio (p less than 0.001) when compared to murine fibrosarcomas. The EMT-6 tumors in contrast to the fibrosarcomas responded to bleomycin treatment in a dose dependent manner. The results indicate that while in mice the tumor dose closely follows the administered dose, in humans, the tumor dose and the tumor-to-lung ratio in the individual patient cannot be predicted from the administered dose.
Front
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Department of Nuclear Medicine, Rambam Medical Center, Faculty of Medicine, Haifa, Israel.
Israel
O
O
Iosilevsky
G
G
Even-Sapir
E
E
Ben-Haim
S
S
Frenkel
A
A
Ber
R
R
Milstein
D
D
Kolodny
G M
GM
D000368:Aged; D000818:Animals; D001761:Bleomycin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D003037:Cobalt Radioisotopes; D005260:Female; D005354:Fibrosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D051379:Mice; D008875:Middle Aged; D012513:Sarcoma, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
D003037:Cobalt Radioisotopes; D001761:Bleomycin