Hematological and biochemical studies in children with Down syndrome.
Eighty-three children with Down syndrome were submitted to hematological and biochemical studies; 69 normal children were included as controls. The variables analyzed were: HbF, HbA2, serum B12 vitamin (B12), folates, total iron and iron binding capacity, hematic cytology, and the red blood cell enzymes adenosine deaminase (ADA), glucose-6-phosphate dehydrogenase (G6PD) and superoxide dismutase (SOD). The most relevant results were: macrocytosis, normal leucocytes, HbF, B12 and folates, as well as high levels of the enzymes ADA and G6PD. An indirect association between macrocytosis, ADA and G6PD is discussed.
Ibarra
B
B
División de Genética, Hospital de Especialidades del Centro Médico de Occidente, IMSS, Guadalajara, Jalisco, Mexico.
Rivas
F
F
Medina
C
C
Franco
M E
ME
Romero-García
F
F
Enriquez
C
C
Galarza
M
M
Hernández-Córdova
A
A
Hernández
T
T
D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood*; D004798:Enzymes / Q000097:blood; D004909:Erythrocyte Indices; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006443:Hemoglobin A2 / Q000032:analysis; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood; D008297:Male; D014815:Vitamins / Q000097:blood
D004798:Enzymes; D014815:Vitamins; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin; D007501:Iron