Approaches to the design of biochemical probes for positron emission tomography.
Since the development of the 2-deoxy-D-glucose procedure by L. Sokoloff considerable advances have been made in the design of radiotracers for estimation of in-vivo biochemical parameters. Many of these advances are due to the development of positron emission tomography. As a result key biochemical processes can now be evaluated with newly developed positron-emitting labeled enzyme probes in man, in-vivo, allowing the study of a wide range of specific cellular processes in health and disease states.
Barrio
J R
JR
Department of Radiological Sciences and Pharmacology, UCLA School of Medicine 90024.
D000818:Animals; D015335:Molecular Probes; D018377:Neurotransmitter Agents / Q000378:metabolism; D011869:Radioligand Assay; D014055:Tomography, Emission-Computed
D015335:Molecular Probes; D018377:Neurotransmitter Agents