Substance P afferents have synaptic contacts with dopaminergic neurons in the ventral tegmental area of the rat.
Synaptic contacts were found between dopaminergic neurons and substance P (SP)-immunoreactive axon terminals in the ventral tegmental area (VTA), by means of the immunoelectron microscopic mirror method. SP-immunoreactive terminals were found to make synaptic contact with VTA neurons exhibiting tyrosine hydroxylase immunoreactivity.
First Department of Anatomy, Osaka City University Medical School, Japan.
R
R
Tamiya
M
M
Hanada
Y
Y
Kawai
S
S
Inagaki
H
H
Takagi
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure; D013681:Tegmentum Mesencephali / Q000378:metabolism* / Q000648:ultrastructure
D013373:Substance P; D004298:Dopamine