The nucleotide sequence of a cDNA encoding an EGF-inducible gene indicates the existence of a new family of mitogen-induced genes.
A gene, cMG1, whose expression is transiently activated in growth factor stimulated epithelial cells has been identified by differential screening. Overlapping cDNA recombinants derived from cMG1 mRNA have been sequenced and shown to encode a protein of 338 amino acids. Database searches have revealed no similarities between cMG1 and other genes, except that over a 67-amino acid region the cMG1 protein shows 72% identity to the product of the TIS11 gene, a TPA-induced sequence in Swiss 3T3 cells. The results suggest that these two genes code for a novel type of early response gene.
Department of Biochemistry, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK.
M
M
Gomperts
J C
JC
Pascall
K D
KD
Brown
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D004268:DNA-Binding Proteins; D004815:Epidermal Growth Factor / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology*; D017874:Immediate-Early Proteins; D008969:Molecular Sequence Data; D005810:Multigene Family; D011506:Proteins / Q000235:genetics*; D051381:Rats; D051816:Tristetraprolin
D004268:DNA-Binding Proteins; D006133:Growth Substances; D017874:Immediate-Early Proteins; D011506:Proteins; D051816:Tristetraprolin; C497554:Zfp36 protein, rat; D004815:Epidermal Growth Factor; D004247:DNA