[Effect of acute aprotinin (Gordox) therapy on hemostasis in heart surgery patients, with special reference to hyperfibrinolysis].
Authors have studied the effect of Gordox-therapy on haemostasis after open heart surgery in a prospective clinical trial. Thirty seven patients (pts) undergoing cardiac surgery due to their valve disease were randomly assigned either to control-group (20 pts) or to Gordox-group (17 pts). The patients in the Gordox group were given Gordox according the following scheme: 2 M IU within 20 min. after induction of anaesthesia followed by 0.5 M IU/hour infusion until the end of the operation. One M IU also was given into the oxygenator before starting the extracorporeal circulation. The postoperative chest tube drainage was less in Gordox-group (534 +/- 260 ml vs. 987 +/- 583 ml, p less than 0.005), and donor blood and fresh frozen plasma requirement was also lower in this group (534 +/- 633 ml vs. 935 +/- 718 ml p less than 0.05; 70 +/- 153 ml vs. 211 +/- 245 ml p less than 0.05, respectively). There was no significant difference between the two groups concerning the postoperative activated partial thromboplastin time, prothrombin time, thrombin time values. The authors could document significantly higher fibrinogen concentration and significantly lower fibrinolytic activity postoperatively in the Gordox-group (p less than 0.05). Gordox therapy has advantageous effect on haemostasis after open heart surgery which can be documented both by clinical and laboratory examination.
II. Sebészeti Klinika, Debreceni Orvostudományi Egyetem.
J
J
Szécsi
E
E
Bátonyi
I
I
Rédai
Z
Z
Szabó
K
K
Herman
P
P
Liptay
I
I
Medgyessy
A
A
Péterffy
D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use*; D006348:Cardiac Surgical Procedures; D004341:Drug Evaluation; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D011446:Prospective Studies; D014361:Trypsin Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D014361:Trypsin Inhibitors; C011475:gordox; D007611:Aprotinin
Az akut aprotinin (Gordox) terápia hatása a haemostasisra szívsebészeti betegekben, különös tekintettel a hyperfibrinolysisre.