New mechanisms of gene amplification in drug resistance (the episome model).
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Von Hoff
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001221:Aspartate Carbamoyltransferase / Q000235:genetics; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D016466:CHO Cells / Q000187:drug effects; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000235:genetics; D006224:Cricetinae; D004270:DNA, Circular / Q000235:genetics / Q000302:isolation & purification; D004273:DNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D004080:Dihydroorotase / Q000235:genetics; D004351:Drug Resistance; D016521:Electrophoresis, Gel, Pulsed-Field; D005111:Extrachromosomal Inheritance; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D008562:Membrane Glycoproteins / Q000235:genetics; D009097:Multienzyme Complexes / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics; D009857:Oncogenes; D010746:Phosphonoacetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010957:Plasmids
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; C033626:CAD trifunctional enzyme; D004270:DNA, Circular; D004273:DNA, Neoplasm; D008562:Membrane Glycoproteins; D009097:Multienzyme Complexes; D001224:Aspartic Acid; C013195:sparfosic acid; D001221:Aspartate Carbamoyltransferase; D004080:Dihydroorotase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); D010746:Phosphonoacetic Acid