Low activity of gamma-glutamyl transpeptidase in serum of acute intrahepatic cholestasis.
Low gamma-glutamyl transpeptidase (gamma-GTP) activity in serum was observed in 11 patients with acute intrahepatic cholestasis (cholestatic hepatitis and fulminant hepatitis), despite a marked increase in bilirubin levels. Inhibitors of gamma-GTP were not detected in sera of these patients. Their gamma-GTP levels in the liver were significantly higher than those in chronic liver diseases. An electrophoretic study of liver gamma-GTP in acute intrahepatic cholestasis showed the same mobility as in chronic liver diseases. These results suggest that the low serum gamma-GTP activity in acute intrahepatic cholestasis is due to factors inhibiting the release of the enzyme from the liver.
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
E
E
Kajiwara
K
K
Akagi
H
H
Tsuji
K
K
Murai
M
M
Fujishima
D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000032:analysis; D002780:Cholestasis, Intrahepatic / Q000378:metabolism*; D005260:Female; D006505:Hepatitis / Q000150:complications; D006801:Humans; D007527:Isoenzymes; D008099:Liver / Q000201:enzymology*; D008297:Male; D013997:Time Factors; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors / Q000097:blood* / Q000378:metabolism
D007527:Isoenzymes; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D001663:Bilirubin