Is multi-infarct dementia representative of vascular dementias? A retrospective study.
Multi-infarct dementia (MID) indicates a dementia disorder primarily caused by multiple cerebral infarcts. Since other pathogenetic mechanisms cause vascular dementia we evaluated clinical, CT scan and CSF neurochemical parameters of 134 MID and 67 PVD (probable vascular dementia) patients. We found no differences with regard to the presence of major risk factors. Only TIA/stroke episodes and focal neurological signs were significantly more frequent in MID than in PVD cases, an anticipable result on the basis of MID definition. CT scan findings showed a prevalence of subcortical with respect to cortical lesions in both groups, with a higher frequency in MID patients. Subjects with deep infarcts more frequently showed TIA/stroke episodes and diabetes mellitus. No differences were detectable in CSF monoamine metabolite levels. We conclude that in the majority of vascular dementias subcortical damage seems to have a major pathogenetic role.
Department of Gerontology and Geriatrics, University of Perugia, Italy.
L
L
Parnetti
P
P
Mecocci
C
C
Santucci
A
A
Gaiti
A
A
Petrini
A
A
Longo
D
D
Cadini
N
N
Caputo
E
E
Signorini
U
U
Senin
D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology; D015161:Dementia, Multi-Infarct / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D015140:Dementia, Vascular / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D002546:Ischemic Attack, Transient / Q000175:diagnosis; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed
D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid