The regulation and expression of MHC class I genes.
The expression of mouse MHC class I genes and their products in vivo reveals complex patterns of regulation. Different promoter elements, which are required for gene activation or modulation in response to various external stimuli, have now been characterized as well as the proteins that bind to them. As described here by Brigitte David-Watine and colleagues, the picture that has gradually emerged from these in vitro studies is of an intricate interplay of transacting factors that ultimately lead to the fine tuning of MHC class I expression in vivo.
David-Watine
B
B
Unité de Biologie Moléculaire du Gène-U.277 INSERM, UAC 115 CNRS, Institut Pasteur, Paris, France.
Israël
A
A
Kourilsky
P
P
D000256:Adenoviridae / Q000235:genetics / Q000502:physiology; D000818:Animals; D001483:Base Sequence; D002472:Cell Transformation, Viral; D000242:Cyclic AMP / Q000502:physiology; D005786:Gene Expression Regulation; D005805:Genes, MHC Class I; D006183:H-2 Antigens / Q000096:biosynthesis / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D007372:Interferons / Q000494:pharmacology; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D051381:Rats; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000502:physiology; D015533:Transcriptional Activation
D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens; C040588:Tla antigens; D014157:Transcription Factors; D007372:Interferons; D000242:Cyclic AMP