Retinoic acid, a developmental signalling molecule.
Retinoic acid has been used as a tool both by embryologists studying the spatial organization of cells in the embryo and by molecular biologists studying the control of gene expression in the nucleus. Embryologists have shown that retinoic acid can modify the pattern of cell differentiation so as to duplicate complete parts of the embryo in a well-organized way; molecular biologists have shown that retinoic acid can act as the switch starting the sequence of differential gene expression that results in cell differentiation. In the past year these two approaches have converged so that there now seems a real possibility that we may soon for the first time understand how a particular vertebrate development system works.
National Institute for Medical Research, Ridgeway, Mill Hill, London, UK.
D
D
Summerbell
M
M
Maden
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D005314:Embryonic and Fetal Development; D018168:Receptors, Retinoic Acid; D014212:Tretinoin / Q000378:metabolism*
D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D014212:Tretinoin