HI-6 in man: efficacy of the oxime in poisoning by organophosphorus insecticides.
The efficacy of the oxime HI-6 was studied as a treatment for organophosphorus poisoning. HI-6 was given four times daily as a single intramuscular injection of 500 mg accompanied by atropine and diazepam therapy. Oxime treatment was started on admission and continued for a minimum of 48 h and a maximum of 7 d. HI-6 rapidly reactivated human blood acetylcholinesterase inhibited by dimethoxy organophosphorus compounds, while the dimethoxy-inhibited enzyme was mainly resistant to the treatment by HI-6. Although both HI-6 and pralidoxime chloride reactivated the red blood cell cholinesterase in quinalphos-poisoned subjects, the return of enzyme activities was more rapid following the use of HI-6. The general improvement of poisoned patients, which was sometimes more rapid than the rise of acetylcholinesterase activity, pointed to direct pharmacological effects of HI-6. No undesirable side-effects were noted in patients when HI-6 plasma concentrations were maintained at levels far above the 'therapeutic' concentration for up to 7 d.
Military Medical Academy, Clinic of Toxicology and Clinical Pharmacology, Belgrade, Yugoslavia.
R
R
Kusić
D
D
Jovanović
S
S
Randjelović
D
D
Joksović
V
V
Todorovic
B
B
Bosković
M
M
Jokanović
V
V
Vojvodić
D000328:Adult; D000931:Antidotes / Q000627:therapeutic use*; D002801:Cholinesterase Reactivators / Q000097:blood / Q000627:therapeutic use*; D002802:Cholinesterases / Q000097:blood; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009943:Organophosphorus Compounds; D010091:Oximes / Q000097:blood / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy / Q000201:enzymology; D011726:Pyridinium Compounds / Q000097:blood / Q000627:therapeutic use*
D000931:Antidotes; D002801:Cholinesterase Reactivators; D007306:Insecticides; D009943:Organophosphorus Compounds; D010091:Oximes; D011726:Pyridinium Compounds; D002802:Cholinesterases; C022870:asoxime chloride