Activation of transcription factor NF kappa B in Jurkat cells is inhibited selectively by FK 506 in a signal-dependent manner.
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M S
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Department of Molecular Biology, Vertex Pharmaceuticals Inc, Cambridge, MA 02139-4211.
Semerjian
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D001483:Base Sequence; D002460:Cell Line; D016572:Cyclosporine / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D015759:Ionomycin / Q000494:pharmacology; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides; D011090:Polyenes / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*; D020123:Sirolimus; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D016559:Tacrolimus / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects
D007166:Immunosuppressive Agents; D016328:NF-kappa B; D009838:Oligodeoxyribonucleotides; D011090:Polyenes; D015759:Ionomycin; D016572:Cyclosporine; D013755:Tetradecanoylphorbol Acetate; D020123:Sirolimus; D016559:Tacrolimus