[Inhibition of Chlamydia trachomatis multiplication by interferon inducer larifan in mice with experimental infection].
Interferon (IF)-inducing capacity of C. trachomatis was shown in experiments on mice CBA. The levels of IF production in the parenchymatous organs correlated with accumulation of the pathogen in them. The use of larifan, a natural double-stranded IF inductor, according to the treatment scheme provided high levels of endogenic IF in infected mice. It inhibited multiplication of Chlamydiae in the lungs and lymph nodes detected cytoscopically by light and fluorescence microscopy and with infection titration. The effect of the inductor combined with tetracycline was of additive nature. Double intraperitoneal administration of larifan with an account of the hyporeactivity phase and daily administration of tetracycline proved to be the most efficient. It is possible to successfully use IF inductors in accordance with the treatment schemes in infection caused by C. trachomatis which makes promising their clinical application in therapy of chlamydiosis.
Vinograd
N A
NA
Saĭitkulov
A M
AM
Tazulakhova
E B
EB
Ersnov
F I
FI
D000818:Animals; D002690:Chlamydia Infections / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000187:drug effects; D004195:Disease Models, Animal; D004357:Drug Synergism; D066298:In Vitro Techniques; D007369:Interferon Inducers / Q000008:administration & dosage*; D007372:Interferons / Q000096:biosynthesis*; D051379:Mice; D008808:Mice, Inbred CBA; D009930:Organic Chemicals; D013752:Tetracycline / Q000008:administration & dosage*
D007369:Interferon Inducers; D009930:Organic Chemicals; C066530:larifan; D007372:Interferons; D013752:Tetracycline
Podavlenie induktorom interferona larifanom razmnozheniia Chlamydia trachomatis pri eksperimental'noĭ infektsii mysheĭ.