Dietary regulation of fructose metabolism in the intestine and in the liver of the rat. Duration of the effects of a high fructose diet after the return to the standard diet.
In this research on metabolic effects of a high fructose diet, we studied the duration of these effects by measuring the specific activity of 8 enzymes stimulated by such a diet, on days, 0, 3, 6, 9, 15, after the return to a normal diet. In the intestinal mucosa, ketohexokinase, aldolase, triokinase, fructose-diphosphatase, and glucose-6-phosphatase specific activities were still entirely or partially stimulated on the 15th day after return to the standard diet. The stimulation of glucose-6-phosphatase and pyruvate kinase specific activities stopped quickly. In the liver, with the exception of fructose-diphosphatase, the return to basic values was much quicker than in intestine. In 7 enzymes out of 8 it was realized in 9 days or less. When a high fructose diet gives way to a normal one, return to basic values comes so much the quicker as activation has needed longer to appear.
Korieh
A
A
Laboratoire de Physiologie générale et comparée, Université Claude Bernard, Lyon, France.
Crouzoulon
G
G
D000818:Animals; D004247:DNA / Q000378:metabolism; D004032:Diet; D005631:Fructokinases; D005632:Fructose / Q000378:metabolism*; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005947:Glucose / Q000096:biosynthesis; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010770:Phosphotransferases / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor); D011506:Proteins / Q000378:metabolism; D011770:Pyruvate Kinase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013393:Sucrase / Q000378:metabolism
D011506:Proteins; D005632:Fructose; D004247:DNA; D010770:Phosphotransferases; D005631:Fructokinases; D017853:Phosphotransferases (Alcohol Group Acceptor); C023190:triokinase; C021475:ketohexokinase; D011770:Pyruvate Kinase; D006597:Fructose-Bisphosphatase; D013393:Sucrase; D005634:Fructose-Bisphosphate Aldolase; D005956:Glucose-6-Phosphate Isomerase; D005947:Glucose