Essential fatty acids and their metabolites in signal transduction.
The above examples argue that the diversity of eicosanoid structures is reflected in distinct actions, that the membrane-permeable nature of these molecules provides a system for interactive cellular signalling that may be particularly important in the nervous system, and that convincing evidence exists for direct actions of eicosanoids on both ion channels and kinases, as well as G-protein-coupled receptors.
Wood
J N
JN
Sandoz Institute for Medical Research, London, U.K.
D000818:Animals; D015777:Eicosanoids / Q000502:physiology; D005228:Fatty Acids, Essential / Q000378:metabolism / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology; D007473:Ion Channels / Q000502:physiology; D008560:Membrane Fluidity; D011494:Protein Kinases / Q000378:metabolism; D015398:Signal Transduction
D015777:Eicosanoids; D005228:Fatty Acids, Essential; D007473:Ion Channels; D011494:Protein Kinases; D019204:GTP-Binding Proteins