title: [Abnormal platelet function and ultrastructure in patients with severe viral hepatitis].
abstract: A study of aggregation and release function of platelet and its ultrastructure in 27 patients with severe viral hepatitis (SVH) was carried out. The results showed that a) the maximum aggregation rate (MAR) decreased markedly; b) platelet 5-HT decreased strikingly and plasma 5-HIs increased significantly; c) the change of MAR was in positive correlation with that of platelet 5-HT and platelet 5-HT/plasma 5-HIs and the change of platelet 5-HT was in negative correlation with that of plasma 5-HIs; d) the ultrastructural abnormalities of platelet suggested its renewal, denaturation and activation in vivo. These results indicate that the abnormal platelet function and ultrastructure in patients with SVH are mainly related to the activation of platelet in vivo.
authors.affiliation: Southwest Hospital, Third Military Medical College, Chongqing.
authors.forename: Y M
authors.initials: YM
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000648:ultrastructure*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000097:blood*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D012701:Serotonin / Q000097:blood
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid