Protective effect of liposome-entrapped superoxide dismutase and catalase on bleomycin-induced lung injury in rats. I. Antioxidant enzyme activities and lipid peroxidation.
The influence of liposome-entrapped catalase and/or superoxide dismutase on bleomycin-induced rat lung injury was studied. Liposome-entrapped catalase and/or superoxide dismutase increase antioxidant enzyme activities in the lung tissue of bleomycin-treated rats. The level of lipid peroxidation products (malondialdehyde, conjugated dienes, lipid hydroperoxides) was significantly lower in liposome-entrapped catalase and/or superoxide dismutase supplemented rats with bleomycin-injured lungs. It is suggested that liposomes are good vectors for drugs in the treatment of bleomycin-induced lung fibrosis.
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Department of Pathophysiology, Veterinary Faculty, Agricultural Academy, Lublin, Poland.
D000818:Animals; D001761:Bleomycin / Q000009:adverse effects*; D002374:Catalase / Q000008:administration & dosage / Q000378:metabolism*; D004337:Drug Carriers; D015227:Lipid Peroxidation; D008081:Liposomes; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000378:metabolism*
D004337:Drug Carriers; D008081:Liposomes; D001761:Bleomycin; D002374:Catalase; D013482:Superoxide Dismutase