Mast cells from human gastric mucosa: a comparative study with lung and colonic mast cells.
Mast cells isolated from human gastric mucosa released histamine on challenge with IgE-directed ligands and calcium ionophores but were essentially unresponsive to a variety of non-immunological stimuli. Moreover, immunologically induced histamine secretion from these cells was inhibited by a number of anti-allergic agents including anti-asthmatic chromones, beta-adrenoceptor agonists and phosphodiesterase inhibitors. In total, these data indicate that mast cells from the human gastric mucosa are in many respects functionally similar to their lung and colonic counterparts.
Liu
W L
WL
Department of Chemistry, University College of London, UK.
Boulos
P B
PB
Lau
H Y
HY
Pearce
F L
FL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D003106:Colon / Q000166:cytology*; D003208:Concanavalin A / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology; D005753:Gastric Mucosa / Q000166:cytology*; D006636:Histamine Release; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D015759:Ionomycin / Q000494:pharmacology; D008168:Lung / Q000166:cytology*; D008407:Mast Cells / Q000276:immunology / Q000502:physiology*; D017835:Nedocromil; D015363:Quinolones / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000888:Antibodies, Anti-Idiotypic; D015363:Quinolones; D017835:Nedocromil; D003208:Concanavalin A; D007073:Immunoglobulin E; D000001:Calcimycin; D015759:Ionomycin; D013806:Theophylline; D004205:Cromolyn Sodium