Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat.
The antidepressant drug tianeptine increased rat plasma 5-hydroxyindoleacetic (5-HIAA) concentrations after single and repeated treatment for 14 days. This effect was not due to an increase in 5-hydroxytryptamine (5-HT) synthesis, as measured by the accumulation of 5-hydroxytryptophan in plasma and brain. A concurrent decrease in platelet-free plasma 5-HT concentrations occurred after subchronic treatment. Tianeptine attenuated the large increase in 5-HT concentrations in platelet-free plasma elicited by the specific 5-HT uptake inhibitors citalopram and paroxetine. These data are compatible with the reported 5-HT uptake-enhancing activity of this antidepressant drug.
Ortiz
J
J
Department of Neurochemistry, C.S.I.C., Barcelona, Spain.
Mocaër
E
E
Artigas
F
F
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D008297:Male; D014179:Neurotransmitter Uptake Inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000096:biosynthesis / Q000097:blood*; D013841:Thiazepines / Q000494:pharmacology*; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D014179:Neurotransmitter Uptake Inhibitors; D013841:Thiazepines; C050504:tianeptine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid