Haplotype specific homology scanning algorithm to predict T-cell epitopes from protein sequences.
We present a homology scanning microcomputer program to predict functional T-cell epitopes within proteins. By taking into account particular human or mouse restriction elements the predictions are made haplotype-specific. The generality of this approach is confirmed by (i) identification of well-characterized immunogenic T-cell determinants in lysozyme (ii) search for potential T epitopes on unanalysed proteins like the human beta 2-adrenoreceptor (iii) modification of non-immunogenic peptide sequences in order to generate T-cell determinants.
Guillet
J G
JG
Laboratoire d'Immunopharmacologie Moléculaire, CNRS UPR 0415, Paris, France.
Hoebeke
J
J
Lengagne
R
R
Tate
K
K
Borras-Herrera
F
F
Strosberg
A D
AD
Borras-Cuesta
F
F
D000465:Algorithms; D000595:Amino Acid Sequence; D000818:Animals; D002478:Cells, Cultured; D004529:Egg White; D000939:Epitopes / Q000737:chemistry; D006239:Haplotypes; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008838:Microcomputers; D008969:Molecular Sequence Data; D009113:Muramidase / Q000276:immunology; D011943:Receptors, Adrenergic, beta / Q000737:chemistry / Q000276:immunology; D012689:Sequence Homology, Nucleic Acid; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D011943:Receptors, Adrenergic, beta; D009113:Muramidase