[Antibodies to anticoagulants in rheumatic autoimmune diseases].
The systemic lupus erythematosus (SLE) and the rheumatoid arthritis (RA) as the classic autoimmune diseases exhibit a great number of autoantibodies. Some of them are anticoagulants. Besides inactivating inhibitors against single coagulation factors interfering anticoagulants are known, belonging to the group of anti-phospholipid antibodies and detected as the lupus anticoagulants or anticardiolipin antibodies. Anti-phospholipid antibodies 184 patients with SLE or RA had been checked for. An enzyme immuno assay was used for detection of the anti-cardiolipin antibodies. The relations between occurrence of the anti-cardiolipin antibodies and vascular processes as well as other immunologic parameters had been tested for clinical relevancy.
Gromnica-Ihle
E
E
Rheumaklinik, Klinikums Berlin-Buch.
Schössler
W
W
Franz
J
J
Ziemer
S
S
Hüge
H
H
Apostoloff
E
E
D000328:Adult; D000925:Anticoagulants / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D002308:Cardiolipins / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000276:immunology*
D000925:Anticoagulants; D001323:Autoantibodies; D015415:Biomarkers; D002308:Cardiolipins; D010743:Phospholipids
Hemmkörper der Blutgerinnung bei Autoimmunerkrankungen des rheumatischen Formenkreises.