Mathematical model of antiviral immune response regulation. I. Conceptual description of the modelled processes.
The report covers the initial steps in construction of a mathematical model, namely a conceptual description of antiviral immune response regulation. The model describes cellular and molecular levels of the basic mechanisms: interaction of virus with a sensitive cell; action and activation of nonspecific resistance factors (phagocytosis, antiviral action of interferon, humoral inhibitors, and natural killer cells in the course of the immune response; humoral and cellular immune response induction and the specific antiviral defence mechanisms. Two helper cell subpopulations are considered explicitly: cellular immune response T helper cells, also named inflammatory cells (TH1) and humoral immune response T helper cells (TH2). Regulation of interleukin 1-, 2- and 4-induced lymphocyte progression through cell cycle phases is described.
Chuykov
V V
VV
All-Union Research Institute of Molecular Biology, Novosibirsk Region.
Bazhan
S I
SI
Kulichov
V A
VA
D000917:Antibody Formation; D002453:Cell Cycle; D007111:Immunity, Cellular; D007372:Interferons / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008211:Lymphocyte Cooperation; D008954:Models, Biological; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D007375:Interleukin-1; D007376:Interleukin-2; D007372:Interferons