Hyaluronic acid deposition in cardiac myxomas: localization using a hyaluronate-specific binding protein.
Myxomas are the most common primary tumors of the heart. These lesions contain a gelatinous, ground-substancelike material which has been described as glycosaminoglycan in nature. Using a newly developed, cartilage-derived hyaluronic acid-binding protein and a modification of the avidin-biotin immunostaining procedure, we demonstrate that hyaluronic acid is contained in the jellylike material of cardiac myxomas.
Hendin
B N
BN
Department of Pathology, University of California, San Francisco 94143.
Longaker
M T
MT
Finkbeiner
W E
WE
Roberts
L J
LJ
Stern
R
R
D000328:Adult; D002352:Carrier Proteins; D005260:Female; D006338:Heart Neoplasms / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid / Q000032:analysis*; D008875:Middle Aged; D009206:Myocardium / Q000737:chemistry / Q000473:pathology; D009232:Myxoma / Q000737:chemistry* / Q000473:pathology; D013194:Staining and Labeling
D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid