title: Absence of mutagenicity of the antitumor drug 3-nitrobenzothiazolo[3,2-a]quinolinium chloride (NBQ) in the germ cells of Drosophila melanogaster males.
abstract: The antitumor drug, 3-nitrobenzothiazolo[3,2-a]quinolinium chloride (NBQ) was tested for genotoxicity with the sex-linked recessive lethal test by feeding Drosophila melanogaster males. Although toxic to adults, the drug tested negative at the concentrations studied.
authors.affiliation: Department of Biology, University of Puerto Rico, Río Piedras 00931.
authors.forename: Y
authors.initials: Y
authors.lastname: Pérez-Chiesa
authors.forename: A
authors.initials: A
authors.lastname: Arroyo
authors.forename: D
authors.initials: D
authors.lastname: Rodriguez
authors.forename: A
authors.initials: A
authors.lastname: Rodriguez-Stoehr
authors.forename: O
authors.initials: O
authors.lastname: Cox
authors.forename: H R
authors.initials: HR
authors.lastname: Retamozo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods; D011806:Quinolinium Compounds / Q000633:toxicity*
chemical_list: D000970:Antineoplastic Agents; D011806:Quinolinium Compounds; C038668:3-nitrobenzothiazolo(3,2-a)quinolinium