title: Stimulation of frog ciliated cells in culture by acetylcholine and substance P.
abstract: 1. Ciliary beat frequency in epithelial outgrowths from cultured explants of Rana pipiens palate changed markedly from second to second. 2. Acetylcholine (10(-8) to 10(-3) M) and substance P (1.35 x 10(-7) to 1.35 x 10(-5) M) increased and stabilized ciliary beat frequency. The effect of acetylcholine and part of the effect of substance P were blocked by atropine (10(-4) M). 3. Acetylcholine appears to act directly and substance P both directly and indirectly through the release of acetylcholine.
authors.affiliation: Department of Biological Sciences, Fordham University, Bronx, NY 10458.
authors.forename: E
authors.initials: E
authors.lastname: Aiello
authors.forename: J
authors.initials: J
authors.lastname: Kennedy
authors.forename: C
authors.initials: C
authors.lastname: Hernandez
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002478:Cells, Cultured; D002923:Cilia / Q000187:drug effects* / Q000502:physiology; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D008853:Microscopy / Q000379:methods; D009061:Mouth Mucosa / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D009079:Mucociliary Clearance / Q000187:drug effects; D009093:Mucus / Q000378:metabolism; D010159:Palate / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D011894:Rana pipiens; D013268:Stimulation, Chemical; D013373:Substance P / Q000494:pharmacology*; D014741:Video Recording
chemical_list: D013373:Substance P; D000109:Acetylcholine; D002211:Capsaicin