Effects of Bay K 8644 and nifedipine on locomotor activity and striatal homovanillic acid concentration in acutely ethanol-treated rats.
The possible involvement of voltage sensitive calcium channels (VSCCs) in both locomotor activity and striatal homovanillic acid (HVA) alterations in acutely low (0.5 g/kg) and high (2 g/kg) dose ethanol-treated rats was investigated. Both doses of ethanol produced inhibitory effects on both locomotor activity and striatal HVA levels. Bay K 8644 significantly potentiated and nifedipine reversed the locomotor inhibitory effect of low-dose ethanol, whereas both drugs did not alter locomotor activity and striatal HVA levels, when used alone. On the other hand, both Bay K 8644 and nifedipine significantly reversed the decrease in striatal HVA levels induced by the low and high doses of ethanol.
Tuna
R K
RK
Department of Pharmacology, Istanbul Faculty of Medicine, University of Istanbul, Turkey.
Eroğlu
L
L
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000032:analysis*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D014793:Visual Cortex / Q000737:chemistry / Q000187:drug effects*
D004338:Drug Combinations; D000431:Ethanol; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D009543:Nifedipine; D006719:Homovanillic Acid