title: Rat mast cells inhibit platelet aggregation by releasing a nitric oxide-like factor: influence of histamine release.
abstract: In th present paper we report the ability of rat serosal mast cells (MC) to release a nitric oxide (NO)-like factor by the inhibition of platelet aggregation and the effect of sodium nitroprusside (NaNP, a NO-generating drug) on MC histamine release by different stimuli.
authors.affiliation: Department of Preclinical and Clinical Pharmacology, Florence, Italy.
authors.forename: P F
authors.initials: PF
authors.lastname: Mannaioni
authors.forename: E
authors.initials: E
authors.lastname: Masini
authors.forename: A
authors.initials: A
authors.lastname: Pistelli
authors.forename: D
authors.initials: D
authors.lastname: Salvemini
authors.forename: J R
authors.initials: JR
authors.lastname: Vane
mesh_terms: D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism* / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D009599:Nitroprusside; D009569:Nitric Oxide; D000001:Calcimycin; D013917:Thrombin