title: Cytokines and transcription factors.
abstract: Transcriptional induction is mediated by transcription factors, which influence gene expression by interacting with specific elements in their regulatory regions. Here we discuss transcription factors involved in the regulation of cytokines and their receptors (interleukin-2, interleukin-2 receptor alpha chain, and interferon-beta), as well as transcription factors that are activated by cytokines (interleukin-1, tumor necrosis factor, interferons, and transforming growth factor beta).
authors.affiliation: Biological Carcinogenesis Development Program, BRMP, National Cancer Institute, NIH, Frederick, MD 21701.
authors.forename: K
authors.initials: K
authors.lastname: Muegge
authors.forename: S K
authors.initials: SK
authors.lastname: Durum
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D007370:Interferon Type I / Q000235:genetics; D007372:Interferons / Q000502:physiology; D007375:Interleukin-1 / Q000502:physiology; D007376:Interleukin-2 / Q000502:physiology; D007377:Interleukin-3 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D015375:Receptors, Interleukin-2 / Q000502:physiology; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D016207:Cytokines; D007370:Interferon Type I; D007375:Interleukin-1; D007376:Interleukin-2; D007377:Interleukin-3; D009687:Nuclear Proteins; D015375:Receptors, Interleukin-2; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007372:Interferons