Toxoplasma gondii: the role of a 30-kDa surface protein in host cell invasion.
C1E3, a monoclonal antibody recognizing protein P30, a major surface antigen of Toxoplasma gondii tachyzoites, was shown to have a consistent effect on invasion in adult bovine kidney cells. In 10 replicate assays, the overall invasion was reduced to 37% of control values (P less than 0.0001). These results support the role of a functional role for P30 in mediating invasion.
Grimwood
J
J
Department of Pure and Applied Biology, University of Leeds, U.K.
Smith
J E
JE
D000818:Animals; D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan / Q000502:physiology; D000954:Antigens, Surface / Q000502:physiology; D002460:Cell Line; D015800:Protozoan Proteins / Q000276:immunology; D014122:Toxoplasma / Q000737:chemistry / Q000472:pathogenicity*
D000911:Antibodies, Monoclonal; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D015800:Protozoan Proteins; C047168:SAG1 antigen, Toxoplasma