[Antigenic diversity of asexual schizont antigen GP195 of Plasmodium falciparum isolates from China].
The antigenic diversity of asexual merozoite surface antigen precursor gp195 among 6 isolates of Plasmodium falciparum from Hainan and Jiangsu provinces of China was investigated with a panel of murine anti-gp195 McAbs by indirect immunofluorescence assay and Western blotting. The results show that all isolates express certain strain-common epitopes of gp195, and at the same time express or lack some strain-specific epitopes. The 6 isolates can be divided into two major gp195 serotypes according to the reactivity patterns with the panel of anti-gp195 McAbs. Remarkable molecular weight difference in gp195 was found among 4 isolates of P. falciparum in which the Jiangsu isolate possesses a large size of gp195 (210kDa) than the other 3 Hainan isolates (less than or equal to 200kDa). The polymorphism of gp195 and it's impact on the development of antimalarial vaccine is discussed.
Miao
W M
WM
Department of Parasitology, Second Military Medical University.
Guan
W B
WB
Pang
W Q
WQ
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D000939:Epitopes; D004912:Erythrocytes / Q000469:parasitology; D010963:Plasmodium falciparum / Q000276:immunology*
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D000939:Epitopes; C057273:antigen gp195, Plasmodium