title: [Infiltrations in gonarthrosis, a therapeutic turning point: the use of a proteinase inhibitor].
abstract: On the basis of evidence of the considerable damage caused by proteolytic enzymes in cases of degenerative arthritis, the authors propose the intra-articular introduction of an inhibitor of these enzymes (aprotinine). Both the immediate and long-term results of this therapy are very promising from a clinical standpoint. This drug not only acted on the symptoms of pain and stiffness, but also blocked the degeneration and consequent cell damage, restoring physiological homeostasis. Considering its high tolerability and absence of side effects, this drug represents a significant turning point in the treatment of degenerative joint disease, with results that are strikingly superior to those achieved with commonly used infiltrative drugs.
authors.affiliation: 1a Facoltà di Medicina e Chirurgia, Istituto 1a Clinica Ortopedica, Università degli Studi di Napoli.
authors.forename: G
authors.initials: G
authors.lastname: Capasso
authors.forename: V
authors.initials: V
authors.lastname: Testa
mesh_terms: D000368:Aged; D007611:Aprotinin / Q000008:administration & dosage / Q000009:adverse effects; D001168:Arthritis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D012074:Remission Induction; D013997:Time Factors
chemical_list: D011480:Protease Inhibitors; D007611:Aprotinin
vernacular_title: Le infiltrazioni nella gonartrosi, una svolta terapeutica: l'uso di un inibitore delle proteinasi.