title: Histological grading of squamous cell carcinoma of the penis: a new scoring system.
abstract: A system of histological grading based on retrospective analysis of 239 patients with squamous cell carcinoma of the penis is presented. A new scoring system with 4 histological grades was used. The results of this study confirm previous reports that penile cancer is usually a highly (50%) or moderately (29%) differentiated squamous cell carcinoma. Poorly differentiated carcinomas and cancers of other types are very rare. The new grading system was found to be practical and a correlation between histological grade, clinical findings and prognosis was established. Patients with grade 1 tumours had an exceptionally favourable prognosis, with more than 80% being long-term survivors; for these patients, treatment with delayed side effects should be avoided and new forms of treatment should be explored.
authors.affiliation: Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.
authors.forename: A G
authors.initials: AG
authors.lastname: Maiche
authors.forename: S
authors.initials: S
authors.lastname: Pyrhönen
authors.forename: M
authors.initials: M
authors.lastname: Karkinen
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D007249:Inflammation; D007633:Keratins; D008297:Male; D008722:Methods; D008875:Middle Aged; D010412:Penile Neoplasms / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D007633:Keratins