Translocation (8;21) in two cases of refractory anemia with excess of blasts in transformation.
We report two cases of refractory anemia with excess of blasts in transformation (RAEB-T) with the translocation (8;21), which is frequent in ANLL but not in myelodysplastic syndromes (MDS). A review of such cases leads us to conclude that myeloproliferative disorders characterized by the t(8;21) may be preceded by an MDS phase.
Maserati
E
E
Biologia Generale e Genetica Medica, Università di Pavia, Italy.
Casali
M
M
Pasquali
F
F
Locatelli
F
F
Giani
S
S
Prete
L
L
Zecca
M
M
Invernizzi
R
R
Bassan
R
R
D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics* / Q000473:pathology; D001752:Blast Crisis; D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic