Use of a conflict procedure in pigeons to characterize anxiolytic drug activity: evaluation of N-methyl-D-aspartate antagonists.
Because of its apparent effectiveness in detecting non-benzodiazepine anxiolytic agents, a recently introduced conflict procedure in pigeons was used to evaluate possible anti-punishment activity of various N-methyl-d-aspartate (NMDA) antagonists. Punished responding was significantly increased by competitive NMDA antagonists (CPP, CGS 19755), but not by noncompetitive NMDA antagonists acting at either the ion channel (PCP, ketamine, MK-801), the glycine site (kynurenic acid, 7-chlorokynurenic acid, ACPC), or the polyamine site (ifenprodil) of the NMDA receptor complex; the proposed glutamate antagonist, riluzole, was also ineffective.
Koek
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Neurobiology Division, FONDAX-Groupe de Recherche SERVIER, Puteaux, France.
Colpaert
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FC
D000818:Animals; D014151:Anti-Anxiety Agents; D001665:Binding Sites / Q000187:drug effects; D010856:Columbidae; D003220:Conflict, Psychological; D005260:Female; D005998:Glycine / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects; D008297:Male; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors*; D011678:Punishment; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism; D013312:Stress, Physiological
D014151:Anti-Anxiety Agents; D007473:Ion Channels; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D005998:Glycine