title: Origin of genetically encoded protein synthesis: a model based on selection for RNA peptidation.
abstract: The difficulty in explaining the origin of genetic coding centres on the need to identify selective advantages that could account for the synthesis of peptidyl-tRNA, the essential intermediate in genetically programmed translation. It is resolved by a recognition of the functional advantages derivable from the post-transcriptional addition of peptide cofactors to RNA apo-catalysts. This enables the formulation of a theory for the origin of the genetic encoding of protein synthesis by RNA.
authors.affiliation: Department of Biochemistry, Hong Kong University of Science & Technology, Clear Water Bay.
authors.forename: J T
authors.initials: JT
authors.lastname: Wong
mesh_terms: D000595:Amino Acid Sequence; D005815:Genetic Code; D008954:Models, Biological; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000235:genetics; D014176:Protein Biosynthesis; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000235:genetics*; D012313:RNA / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional; D012641:Selection, Genetic
chemical_list: D010455:Peptides; D011506:Proteins; D012313:RNA