title: Conformational analysis of the amino termini (5 residues) of human glycophorin AM and AN: differentiation of the structural features of the TN and T antigenic determinants in relation to their specificity.
abstract: The N-terminus of glycophorin A, the main transmembrane erythrocyte glycoprotein responsible for the MN blood-group specificity, has been modelled. As the minimum size of the protein recognised by the antiglycophorin A antibodies is the N-terminal glycopentapeptide, attention was focused on the TN and T antigenic determinants of this size in order to determine wether differences in 3D structure exist and how a specific response with different antibodies is induced.
authors.affiliation: Centre de Recherche sur les Mécanismes de la Croissance Cristalline, Universités d'Aix-Marseille II et III, France.
authors.forename: G
authors.initials: G
authors.lastname: Pèpe
authors.forename: D
authors.initials: D
authors.lastname: Siri
authors.forename: Y
authors.initials: Y
authors.lastname: Oddon
authors.forename: A A
authors.initials: AA
authors.lastname: Pavia
authors.forename: J P
authors.initials: JP
authors.lastname: Reboul
mesh_terms: D000595:Amino Acid Sequence; D002236:Carbohydrate Conformation; D000939:Epitopes / Q000737:chemistry; D006021:Glycophorins / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D007120:Immunochemistry; D008951:MNSs Blood-Group System / Q000276:immunology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D011487:Protein Conformation
chemical_list: D000939:Epitopes; D006021:Glycophorins; D008951:MNSs Blood-Group System; D010446:Peptide Fragments