title: X;6 translocation in a child with congenital acute lymphocytic leukemia.
abstract: A case of congenital acute lymphoblastic leukemia (ALL) displayed an X;6 translocation. This is the third reported case of ALL with an X;6 translocation. In addition, two of the three ALL cases occurred during infancy, at ages 2 months and newborn, and both translocations involved the band q15-16 region of chromosome 6. Anomalies of the long arm of chromosome 6, mainly interstitial and terminal deletions, have been reported as a recurrent karyotypic event in a significant number of ALL cases. The molecular basis and propensity of an X;6 rearrangement in this case of congenital ALL is unclear and merits further investigation. The similarities in this case and the other infant ALL case cited suggest that an X;6 rearrangement with a breakpoint in bands q15-16 of chromosome 6 is characteristic of a form of congenital ALL.
authors.affiliation: Section of Hematology/Oncology, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine.
authors.forename: L A
authors.initials: LA
authors.lastname: Carney
authors.forename: J S
authors.initials: JS
authors.lastname: Kinney
authors.forename: R R
authors.initials: RR
authors.lastname: Higgins
authors.forename: A I
authors.initials: AI
authors.lastname: Freeman
authors.forename: B K
authors.initials: BK
authors.lastname: Hecht
authors.forename: G M
authors.initials: GM
authors.lastname: Woods
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002478:Cells, Cultured; D002871:Chromosome Banding; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000151:congenital / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014960:X Chromosome