Analysis of monoamines in the cerebrospinal fluid of Chinese patients with Alzheimer's disease.
We have established HPLC assay conditions that could measure the levels of 14 monoamines and their metabolites simultaneously. Monoamine levels in cerebrospinal fluids of 12 Chinese patients with Alzheimer's disease were compared with those in samples from patients with benign prostate hyperplasia. Of the 14 monoamines and metabolites, only three were found to be present in all samples. Although the levels of 5-hydroxy-3-indoleacetic acid (HIAA) and homovanillic acid (HVA) in cerebrospinal fluid of patients with Alzheimer's disease were lower, and the levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) higher, as compared to control patients, no significant differences were found between these two groups.
Liu
H C
HC
Neurological Center, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Yang
J C
JC
Chang
Y F
YF
Liu
T Y
TY
Chi
C W
CW
D015102:3,4-Dihydroxyphenylacetic Acid / Q000134:cerebrospinal fluid; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D002681:China; D002851:Chromatography, High Pressure Liquid; D004295:Dihydroxyphenylalanine / Q000134:cerebrospinal fluid; D004298:Dopamine / Q000134:cerebrospinal fluid; D004837:Epinephrine / Q000134:cerebrospinal fluid; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007545:Isoproterenol / Q000134:cerebrospinal fluid; D008676:Metanephrine / Q000134:cerebrospinal fluid; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D014642:Vanilmandelic Acid / Q000134:cerebrospinal fluid
D015102:3,4-Dihydroxyphenylacetic Acid; D008676:Metanephrine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D004295:Dihydroxyphenylalanine; D007545:Isoproterenol; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine