Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro.
The effects of an immunopotentiating drug, isoprinosine, on the splenocytes of BALB/c mice to produce cytokines were investigated. Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro. It also significantly increased the IFN-gamma secretion and decreased the IL-4 production in vivo. The significance of these findings in terms of immune regulation is discussed.
Milano
S
S
Institute of General Pathology, University of Palermo, Italy.
Dieli
M
M
Millott
S
S
Miceli
M D
MD
Maltese
E
E
Cillari
E
E
D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D007542:Inosine Pranobex / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007377:Interleukin-3 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
D007376:Interleukin-2; D007377:Interleukin-3; D015847:Interleukin-4; D007371:Interferon-gamma; D007542:Inosine Pranobex