Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes.
Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.
Brown
W C
WC
Department of Veterinary Pathobiology, Texas A&M University, College Station 77843-4467.
Bissey
L
L
Logan
K S
KS
Pedersen
N C
NC
Elder
J H
JH
Collisson
E W
EW
D000911:Antibodies, Monoclonal / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology*; D016827:CD8 Antigens; D002478:Cells, Cultured; D016181:Feline Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology; D005455:Fluorescent Antibody Technique; D016089:Immunodeficiency Virus, Feline / Q000201:enzymology / Q000502:physiology* / Q000648:ultrastructure; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012191:Retroviridae Proteins / Q000096:biosynthesis; D013047:Specific Pathogen-Free Organisms; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000382:microbiology*
D000911:Antibodies, Monoclonal; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D016827:CD8 Antigens; D012191:Retroviridae Proteins; D012194:RNA-Directed DNA Polymerase