[The biological and immunochemical properties of monoclonal antibodies to the Venezuelan equine encephalomyelitis virus].
Five strains of hybrid cells producing highly active monoclonal antibodies (MCA) to Venezuelan equine encephalomyelitis (VEE) virus were generated. VEEC6 MCA had high virus-neutralizing and hemagglutinating activities attesting to their direction to the "critical" site of E2 glycoprotein. MCA VEEA5 directed to the same glycoprotein did not overlap spatially with the previous one. MCA VEEB5 and VEEA4 interacted with conformational virus determinants taking part in hemagglutination.
Shpilevaia
M V
MV
Tugizov
Sh M
ShM
Kushch
A A
AA
Tsilinskiĭ
Ia Ia
IaIa
Makarova
N E
NE
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology* / Q000302:isolation & purification; D002642:Chick Embryo; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology* / Q000302:isolation & purification; D000939:Epitopes / Q000276:immunology; D007114:Immunization; D007120:Immunochemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D014760:Viral Fusion Proteins / Q000276:immunology; D014776:Virus Cultivation
D000911:Antibodies, Monoclonal; D000939:Epitopes; D014760:Viral Fusion Proteins
Biologicheskie i immunokhmicheskie svoĭstva monoklonal'nykh antitel k virusu venesuél'skogo éntsefalomielita loshadeĭ.