Effect of early corticosteroid therapy for Landau-Kleffner syndrome.
Four children treated for seizures between 1980 and 1986 were diagnosed as having Landau-Kleffner syndrome (acquired aphasia with convulsive disorder), following the onset of aphasia. They received early and prolonged ACTH or corticosteroid therapy, with high initial doses. In all four cases the EEG promptly became normal, with subsequent long-lasting remission of the aphasia and improvement of seizure control. Three to six years after discontinuation of hormone therapy the children are off medication and free from seizures and language disability.
Lerman
P
P
Department of Pediatrics B, Beilinson Medical Centre, Petah Tikva, Israel.
Lerman-Sagie
T
T
Kivity
S
S
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage; D000927:Anticonvulsants / Q000008:administration & dosage; D001037:Aphasia / Q000188:drug therapy*; D002648:Child; D002653:Child Behavior Disorders / Q000188:drug therapy*; D002675:Child, Preschool; D003907:Dexamethasone / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence
D000305:Adrenal Cortex Hormones; D000927:Anticonvulsants; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D011241:Prednisone