[Clinical evaluation of serum basic fetoprotein in patients with urogenital malignancies and renal transplantation].
The serum basic fetoprotein (BFP) in patients with urogenital diseases was measured by enzyme immunoassay (EIA). The positive range of serum BFP was defined to be 75 ng/ml or more. In benign cases except for renal transplantation, the positive rate of serum BFP was 11.1% (5/45), and relatively high (21.4%, 3/14) in benign prostatic hypertrophy. In cases of urogenital cancers before treatment, the positive rate of serum BFP was 29.1% (16/55), and increased with the progression of clinical stage. Eleven of the patients with positive serum BFP before treatment were re-examined after treatment, and all of them exhibited a marked decrease of the titer of serum BFP. In seventeen renal transplant patients, the positive rate of serum BFP was 100% (8/8) in acute rejection, 66.7% (2/3) in chronic rejection and 0% (0/6) in rejection-free condition. We conclude that serum BFP is a clinically beneficial marker for renal transplant rejections and urogenital malignancies.
Seguchi
T
T
Department of Urology, Osaka University Medical School.
Sugao
H
H
Takahara
S
S
Nakano
E
E
Ishibashi
M
M
Sonoda
T
T
D005834:Genital Neoplasms, Male / Q000097:blood* / Q000276:immunology; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D011863:Radioimmunoassay; D014571:Urologic Neoplasms / Q000097:blood* / Q000276:immunology; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins