[Effects of antifeins with different memory effects on cAMP phosphodiesterase, lipid peroxidation and RNA synthesis in rat brain neurons].
It has been shown that ethylnorantifein and its structural analogues with opposite effects on long term memory reduce the activity of membrane bound phosphodiesterase cAMP with high and low affinity and exert the same directed influence on lipids peroxidation in membranes. A positive correlation was observed only between the action of these substances on the long term memory and their influence on the RNA synthesis in the rat brain nuclei. Ethylnorantifein and its demethylated analogues increased RNA synthesizing activity while allyl- and propylnorantifeins decreased it. The molecular mechanisms of memory effects of neuroactive substances are discussed.
Reĭkhardt
B A
BA
Kulikova
O G
OG
Beliavtseva
L M
LM
Borodkin
Iu S
IuS
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000032:analysis*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005042:Etimizol / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D012313:RNA / Q000096:biosynthesis*; D051381:Rats
D012313:RNA; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D005042:Etimizol
Vliianie antifeinov s razlichnymi mnesticheskimi éffektami na fosfodiésterazy tsAMF, perekisnoe okislenie lipidov i sintez RNK v neĭronakh golovnogo mozga krys.