[Determination of nasal transepithelial potential difference (DDPTE) in cystic fibrosis. Analysis of a simplified measurement technique].
Measurements of nasal transepithelial potential differences (TEPD) were performed in 77 patients in order to assess a routine simplified method of recording. TEPD assays were performed in 34 patients with cystic fibrosis aged 1 month to 25 years, in 22 children with another chronic respiratory illness and in 21 subjects without any bronchopulmonary impairment. In the cystic fibrosis group TEPD values (mean +/- SD) were significantly higher (-49.077 +/- 9.38 mV) than in patients with chronic respiratory illnesses (-20.590 +/- 5.011 mV) or in subjects without bronchopulmonary impairment (-19.857 +/- 5.033 mV) (p less than 0.0001). Measurements could not be performed in 10 patients due to major nasal inflammation. The excellent specificity (100%) and sensitivity (93%) of the method confirm its diagnostic value. It may be used from the neonatal period and may represent an alternative to the sweat test, especially in dubious cases.
Labbé
A
A
Service de Pédiatrie A, Hôtel-Dieu, Clermont-Ferrand.
Bellon
G
G
Héraud
M C
MC
Arbre
P
P
Goddon
G
G
Alton
E
E
D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000378:metabolism / Q000503:physiopathology*; D004848:Epithelium / Q000502:physiology; D006801:Humans; D007223:Infant; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009297:Nasal Mucosa / Q000378:metabolism / Q000503:physiopathology*; D012964:Sodium / Q000378:metabolism; D013542:Sweat / Q000737:chemistry
D007473:Ion Channels; D012964:Sodium
Détermination des différences de potentiel transépithélial (DDPTE) nasal dans la mucoviscidose. Analyse d'une méthode de mesure simplifiée.