Alcoholic hepatitis with hyperleukocytosis.
We report a fatal case of alcoholic hepatitis with hyperleukocytosis mainly consisting of mature granulocytes in a 43-year-old woman. White blood cell count was increased in parallel with clinical deterioration to 54,800/mm3 with no immature neutrophils on a differential count. The bone marrow aspirate revealed normal maturation and no evidence of hematological malignancy. It has been postulated that severe leukocytosis accompanied by alcoholic hepatitis may be provoked by release of high levels of colony stimulating factor from damaged hepatic cells. However, the present patient showed a normal level of serum granulocyte colony stimulating factor, and could not prove the above assumption.
Koyama
Y
Y
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Imoto
M
M
Fukuda
Y
Y
Nakano
I
I
Hattori
M
M
Urano
F
F
Muzzillo
D A
DA
Nishimura
D
D
Kato
K
K
Kanzaki
M
M
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000032:analysis; D003115:Colony-Stimulating Factors / Q000097:blood; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D006519:Hepatitis, Alcoholic / Q000150:complications*; D006801:Humans; D007958:Leukocyte Count; D007964:Leukocytosis / Q000209:etiology*; D008099:Liver / Q000201:enzymology; D005723:gamma-Glutamyltransferase / Q000097:blood
D003115:Colony-Stimulating Factors; D016179:Granulocyte Colony-Stimulating Factor; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin