Olfactory bulb DA receptors may be located on terminals of the olfactory nerve.
The glomerular layer of the olfactory bulb contains a substantial population of dopaminergic neurons. We determined the quantity and location of D1 and D2 dopamine receptors which are the presumed targets of these neurons. Binding of the D1 selective ligand [3H]SCH23390 was slightly above background and was distributed through all layers of the bulb except the olfactory nerve layer. In contrast there were relatively high levels of [3H]spiperone binding to D2 DA receptors in the glomerular and olfactory nerve layers. The presence of relatively high concentrations of D2 DA receptors in both the nerve layer and glomerular layer suggests the novel hypothesis that these receptors may be localized on terminals of the olfactory nerve.
Nickell
W T
WT
Department of Anatomy, University of Cincinnati College of Medicine, OH 45267.
Norman
A B
AB
Wyatt
L M
LM
Shipley
M T
MT
D000818:Animals; D001552:Benzazepines / Q000378:metabolism; D002069:Butaclamol / Q000494:pharmacology; D008297:Male; D009411:Nerve Endings / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism*; D009832:Olfactory Nerve / Q000378:metabolism*; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D013237:Stereoisomerism; D014018:Tissue Distribution
D001552:Benzazepines; D011954:Receptors, Dopamine; D013134:Spiperone; D002069:Butaclamol