[The role of cAMP in generating mollusk neuron responses, related to negative slope conductance, to dopamine application].
Dopamine (DA)-induced steady-state inward current has been studied in isolated mollusc neurons through two different mechanisms: an increase in the slow potential-dependent Na(+)-conductance and a decrease in the K(+)-conductance. Dibutyryl-cAMP mimicked the both types of DA-responses. 3-Isobutyl-1-methylxanthine (IBMX) in low concentration potentiated DA-responses and in high concentration mimicked them. It was concluded that most of DA-induced inward current responses associated with a negative slope conductance are mediated by cAMP.
Solntseva
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D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology*; D004553:Electric Conductivity / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D012908:Snails / Q000187:drug effects / Q000502:physiology*
D003994:Bucladesine; D000242:Cyclic AMP; D015056:1-Methyl-3-isobutylxanthine; D004298:Dopamine
Rol' tsAMF v generatsii otvetov neĭronov molliuska, sviazannykh s otritsatel'nym soprotivleniem, na applikatsiiu dofamina.