Evidence for a link between mechanical and electrical alternans in acutely ischaemic myocardium of anaesthetized dogs.
In order to examine the relation between mechanical alternans and associated electrical alternans during acute myocardial ischaemia, we determined the effect of a ventricular premature beat and calcium antagonists on mechanical and electrical alternans during acute coronary occlusion in anaesthetized dogs. Isometric contractions and unipolar electrocardiograms were recorded from ischaemic myocardium. During coronary occlusion, mechanical alternans was accompanied by electrical alternans, which was an alternate change in the ST segment elevation, i.e. the higher ST and the lower ST. Electrical alternans was frequently discordant and in some cases accompanied by discordant mechanical alternans. Both discordant electrical and mechanical alternans became concordant and were potentiated after the ventricular premature beat. In all cases, concordant mechanical alternans was accompanied by concordant electrical alternans and vice versa. In this situation, the higher and the lower ST corresponded to the larger and the smaller contractions respectively. Thus, a fixed correspondence was observed between mechanical and electrical alternans. A fixed correspondence was also observed between mechanical alternans and the variation in the time taken for repolarization of the monophasic action potential. Verapamil and diltiazem inhibited both electrical and mechanical alternans. The present results support the idea that a common mechanism, such as a beat-to-beat cycle of the transmembrane and intracellular movement of calcium ions, may play a role in the mechanisms of electrical and mechanical alternans.
Hashimoto
H
H
Department of Pharmacology, Hamamatsu University School of Medicine, Japan.
Nakashima
M
M
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology; D005117:Cardiac Complexes, Premature / Q000473:pathology / Q000503:physiopathology; D003327:Coronary Disease / Q000473:pathology / Q000503:physiopathology*; D004110:Diltiazem / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D009200:Myocardial Contraction / Q000187:drug effects; D010812:Physical Stimulation; D011674:Pulse / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem