title: [Morphology and function of macrophages in AIDS in broncho-alveolar lavages (BAL)].
abstract: HIV infects susceptible T-cell and mononuclear phagocyte targets. Unlike the dramatic changes that occur with T-cells during HIV disease, changes in monocyte and macrophage phenotype and function are qualitatively minimal. The aim of the study was to quantitatively analyze the morphology of macrophages in broncho-alveolar lavages in patients without AIDS, with AIDS, with AIDS complicated by Pneumocystis carinii and in carcinoma patients. In patients with AIDS, the nuclei of macrophages demonstrate a higher integrated optical density (2P less than 0.10), are bigger in size (2P less than 0.05) and have less notches (2P less than 0.02).
authors.affiliation: Institut für Pathologie der Universität, Basel.
authors.forename: M
authors.initials: M
authors.lastname: Oberholzer
authors.forename: P
authors.initials: P
authors.lastname: Dalquen
authors.forename: M
authors.initials: M
authors.lastname: Oestreicher
authors.forename: A
authors.initials: A
authors.lastname: Perruchoud
authors.forename: M
authors.initials: M
authors.lastname: Buser
authors.forename: R
authors.initials: R
authors.lastname: Gschwind
authors.forename: H
authors.initials: H
authors.lastname: Christen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D001991:Bronchitis / Q000473:pathology / Q000503:physiopathology; D001992:Bronchoalveolar Lavage Fluid / Q000473:pathology*; D002283:Carcinoma, Bronchogenic / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology; D008264:Macrophages / Q000473:pathology / Q000502:physiology*; D009894:Opportunistic Infections / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D011020:Pneumonia, Pneumocystis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
vernacular_title: Beobachtungen zur Morphologie und Funktion der Makrophagen bei AIDS an broncho-alveolären Lavagen (BAL).