[Psychopathologic and psychophysiologic follow-up of inpatient depressed patients with standardized treatment with clomipramine and oxaprotiline].
The aim of this study was to show psychopathological and especially psychophysiological data of depressed inpatients which were collected during a 28-day double-blind study with 68 depressed inpatients given clomipramine 150 mgr/die) or maprotiline/oxaprotiline 150 mgr/die). Using Hamilton-Depression-Scale, Self-depression-scale (SDS by Zung), Beschwerdeliste (BL) and Befindlichkeitsskala (Bf-S) by v. Zerssen an impressive reduction of depression scores was observed in all rating scales with some superiority of clomipramine. But at the end of the study at treatment day 28 both groups - clomipramine and maprotiline/oxaprotilin - had similar results. During treatment each patient was part of a weekly habituation experiment using electrodermal activity in an orientation reaction as measure. Contrary to other studies (Lader 1975 or Heimann 1976, 1980) there was no difference in the course of psychophysiological data (EDA) between both treatment groups or between depressive agitation and psychomotor retardation. There was also no relationship between reactivity in EDA at study begin and treatment results.
Steiner
B
B
Psychiatrisches Landeskrankenhaus Weissenau, Universität Ulm.
Wolfersdorf
M
M
Keller
F
F
Straub
R
R
Hole
G
G
D000328:Adult; D000928:Antidepressive Agents; D001143:Arousal / Q000187:drug effects*; D002997:Clomipramine / Q000008:administration & dosage* / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005712:Galvanic Skin Response / Q000187:drug effects; D006185:Habituation, Psychophysiologic / Q000187:drug effects; D006760:Hospitalization; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D010556:Personality Tests / Q000706:statistics & numerical data; D011594:Psychometrics
D000928:Antidepressive Agents; D008376:Maprotiline; C027299:hydroxymaprotilin; D002997:Clomipramine
Psychopathologischer und psychophysiologischer Verlauf bei stationären depressiven Patienten unter standardisierter Behandlung mit Clomipramin bzw. Oxaprotilin.