Interaction of T lymphocytes with cerebral endothelial cells in vitro.
As a prerequisite of inflammatory lesion formation in (auto-)immune disease of the central nervous system, lymphocytes have to interact with brain endothelia. In recent years much progress has been made towards a better understanding of mechanisms and factors involved in organ specific homing of lymphocytes. Many lines of evidence indicate that T lymphocytes recognizing antigens which are exclusively beyond the blood-brain barrier cross this barrier only when they are in an activated state, irrespective of their antigen specificity. Antigen presentation by blood-brain barrier endothelia, however, may play a role in later stages of florid inflammation.
Wekerle
H
H
Max-Planck-Institute for Psychiatry, Munich, Federal Republic of Germany.
Engelhardt
B
B
Risau
W
W
Meyermann
R
R
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D001812:Blood-Brain Barrier; D002465:Cell Movement; D002478:Cells, Cultured; D016207:Cytokines / Q000502:physiology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D007157:Immunologic Surveillance; D008213:Lymphocyte Activation; D051379:Mice; D008817:Mice, Mutant Strains; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology
D016207:Cytokines; D004676:Myelin Basic Protein; D016693:Receptors, Antigen, T-Cell, alpha-beta