Haemocompatibility of extracorporeal circulation technique with autooxygenation: influence on platelet function and homologous blood requirement.
Forty male patients: group A-autooxygenation and group B-bubble oxygenator used in extracorporeal circulation (ECC) were studied to evaluate the haemocompatibility of 2 types of ECC. The Plt count dropped significantly in group B patients: -73% of initial value vs only -27% in group A, (p less than 0.001). In both groups a rise in BTG was shown, but higher in group B, p less than 0.001. At the end of CPB aggregation decreased only slightly in group A after epinephrine and 4-ADP, and decreased hardly in group B with the significant difference between two groups (p less than 0.02 and p less than 0.001, respectively). In group A the mean blood loss was 278 +/- 49 ml/m2 and 483 +/- 67 ml/m2 in group B, p less than 0.001. The mean blood transfusion in group A and B was 198 +/- 82 ml/m2 and 427 +/- 85 ml/m2, respectively (p less than 0.001). We are positive that the elimination of artificial oxygenator from the ECC diminished markedly the decline in Plt count and Plt activation during CPB.
Wojnar
J
J
Clinic of Haematology, Silesian Medical Academy, Katowice, Poland.
Bochenek
A
A
Wnuk-Wojnar
A M
AM
Religa
Z
Z
Hołowiecki
J
J
D001760:Bleeding Time; D001779:Blood Coagulation Factors / Q000032:analysis; D016063:Blood Loss, Surgical; D001792:Blood Platelets / Q000502:physiology*; D001803:Blood Transfusion; D001026:Coronary Artery Bypass; D005112:Extracorporeal Circulation / Q000379:methods*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010974:Platelet Aggregation; D001620:beta-Thromboglobulin
D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D006454:Hemoglobins; D001620:beta-Thromboglobulin; D010100:Oxygen