The role of haematopoietic growth factors in bone marrow transplantation.
Bone marrow transplantation (BMT) is being increasingly used for treating a large number of diseases. The recent availability of haematopoietic growth factors (HGFs) for therapeutic purposes has offered a powerful tool in order to overcome one of the most important BMT-related complications, namely severe myelosuppression. This article, besides an overview on the main results achieved with the clinical use of HGFs for haematopoietic reconstitution after BMT, also deals with some innovative applications of these molecules in BMT setting, as their use for peripheral stem cell transplantation and bone marrow failure after BMT.
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Istituto di Scienze Mediche, Padiglione Granelli, Milano, Italia.
D016026:Bone Marrow Transplantation; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use*; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
D016298:Hematopoietic Cell Growth Factors; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor