Correlation of the percentage of activated, CD3 + DR + lymphocytes to serum neopterin level in HIV-seropositive haemophiliacs.
The percentage of activated, CD3+ DR+ and CD8+ Leu7+ lymphocytes and the serum neopterin concentration were determined in 17 HIV-seropositive and 10 HIV-seronegative haemophiliacs and in 11 healthy control subjects. All three parameters tested were found to be significantly higher in the seropositive patients than in the seronegative controls. In the seropositive group, a significant positive correlation was found between the neopterin levels and the percentage of CD3+ DR+ cells. By contrast, no significant negative or positive correlation was observed between the neopterin levels and the percentage of the CD8+ Leu7+ subset. These data suggest that in the HIV-infected patients the activated T cells responsible for the stimulation of macrophages to produce neopterin are those that do not carry CD8.
Pálóczi
K
K
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Ujhelyi
E
E
Fuchs
D
D
Mihalik
R
R
Bánhegyi
D
D
Berkessy
S
S
Salavecz
V
V
Wachter
H
H
Hollán
S R
SR
Füst
G
G
D000293:Adolescent; D000328:Adult; D000943:Antigens, Differentiation / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D017252:CD3 Complex; D018959:CD57 Antigens; D016827:CD8 Antigens; D002648:Child; D005434:Flow Cytometry; D006679:HIV Seropositivity / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis*; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008262:Macrophage Activation / Q000276:immunology; D019798:Neopterin; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D017252:CD3 Complex; D018959:CD57 Antigens; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D011948:Receptors, Antigen, T-Cell; D001708:Biopterins; D019798:Neopterin