Coxiella burnetii antigens may induce resistance to tumour growth.
Coxiella burnetii antigens stimulate the defence against growth of hepatoma 22a cells. The antigen-stimulated mice survived longer, they considerably later developed palpable tumours and showed a retarded tumour growth. The enhanced resistance to tumour growth may be explained by at least 2 interrelated phenomena; namely by the induction of interferon-like activity and an increased NK cell activity.
Tokarevich
N K
NK
Pasteur Institute of Epidemiology and Microbiology, Leningrad, U.S.S.R.
Maligin
A M
AM
Kramskaya
T A
TA
Pogodina
O N
ON
D000276:Adjuvants, Immunologic; D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D003381:Coxiella / Q000276:immunology*; D007167:Immunotherapy; D007372:Interferons / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D007372:Interferons