title: The natural history of carcinoma of the bile duct in patients less than forty-five years of age.
abstract: Traditionally regarded as a disease of the elderly, the natural history of carcinoma of the bile duct in young patients has not been well defined. Of 186 patients (mean age of 62 years) treated at UCLA (1954 to 1988) for carcinoma of the bile duct, 26 were less than 45 years old. Younger patients had symptoms for an average of 4.5 +/- 0.8 months prior to diagnosis, as compared with 2.3 +/- 0.2 months for patients more than 45 years old (p less than 0.03). Of the younger patients, 96 per cent were managed surgically with either resection, surgical palliative bypass or laparotomy and tube drainage. Among the younger patients who underwent resections, 92 per cent were alive at one year, as compared with 60 per cent of patients who underwent palliative bypass procedures. Two patients who underwent tumor resections survived four years or longer. We conclude that carcinoma of the bile duct is not limited to the elderly and occurs in a significant number of young patients. In the younger population, carcinoma of the bile duct is characterized by delays in diagnosis. Early suspicion and aggressive management of young patients with obstructive jaundice are essential to ensure the best possible outcome for patients with this disease.
authors.affiliation: Department of Surgery, UCLA School of Medicine.
authors.forename: K D
authors.initials: KD
authors.lastname: Saunders
authors.forename: R K
authors.initials: RK
authors.lastname: Tompkins
authors.forename: J A
authors.initials: JA
authors.lastname: Cates
authors.forename: W P
authors.initials: WP
authors.lastname: Longmire
authors.forename: J J
authors.initials: JJ
authors.lastname: Roslyn
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies