Role of ionic currents in the physiological response to angiotensin II.
Studies using conventional and patch-clamp microelectrode techniques demonstrate that in a number of cell types angiotensin II (AII) causes reversible changes in transmembrane ionic currents, and that these effects can be mimicked by various membrane-associated and cytosolic messengers. AII modulates the current amplitude of ion channels, as well as their activation threshold and their open/closed time probability. Stimulatory and inhibitory effects on ion channel activity are a fundamental feature of the development of AII actions on target organs.
Palant
C E
CE
Nephrology Service, Department of Veterans Affairs Hospital, Brooklyn, N.Y.
Ross
M J
MJ
D000302:Adrenal Cortex / Q000502:physiology; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D004594:Electrophysiology; D006321:Heart / Q000502:physiology; D007473:Ion Channels / Q000502:physiology; D007668:Kidney / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology
D007473:Ion Channels; D000804:Angiotensin II