title: [Effect of isoprinosine and acyclovir on the clinical course of chickenpox and herpes zoster].
abstract: The therapeutic effect of isoprinosine and acyclovir have been studied in 352 and 284 patients with chicken-pox and herpes zoster respectively. The patients were divided into 4 groups: the first one was given palliative treatment only, the second--both palliative and isoprinosine ones, the third--palliative and acyclovir treatment, and the fourth group was given all these. The best therapeutic effect was achieved when acyclovir and isoprinosine was applied jointly, the one of acyclovir alone was less pronounced and that of isoprinosine only was the smallest. According to the authors acyclovir should be the treatment of choice in the very severe and severe cases of chicken-pox and herpes zoster; in the early stage of disease it should be supplemented with isoprinosine and passive immunotherapy.
authors.affiliation: Klinika Chorób Zakaźnych dla Dorosłych Instytutu Chorób Zakaźnych, Pasozytniczych Akademii Medycznej, Warszawie.
authors.forename: J
authors.initials: J
authors.lastname: Janeczko
authors.forename: M
authors.initials: M
authors.lastname: Baranowska
authors.forename: B
authors.initials: B
authors.lastname: Romanowska
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D002644:Chickenpox / Q000188:drug therapy*; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007275:Injections, Intravenous; D007542:Inosine Pranobex / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D013997:Time Factors
chemical_list: D007542:Inosine Pranobex; D000212:Acyclovir
vernacular_title: Wpływ izoprynozyny i acyklowiru na przebieg kliniczny ospy wietrznej i półpaśca.