Calmodulin blockers decrease short-term plasticity of the cholinoreceptors of neurons of the edible snail.
A reversible decrease in the rate and depth of the extinction of the reactions of the cholinoreceptive membrane to repeated iontophoretic applications of acetylcholine to the soma by a number of calmodulin blockers was demonstrated in identified RPa3 and LPa3 neurons in the edible snail using the method of recording transmembrane ionic currents: R 24571 (20-50 mumols/liter), trifluoperazine (50-200 mumols/liter), chlorpromazine (20-60 mumols/liter), and prenylamine lactate (30-400 mumols/liter). The results obtained attest to the positive regulation of short-term plasticity of the cholinoreceptors of the neurons in question by calmodulin.
Pivovarov
A S
AS
Department of the Physiology of Higher Nervous Activity, M.V. Lomonosov Moscow State University.
Drozdova
E I
EI
Kotlyar
B I
BI
D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002746:Chlorpromazine / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004558:Electric Stimulation; D006372:Helix, Snails / Q000502:physiology*; D007093:Imidazoles / Q000494:pharmacology; D007473:Ion Channels / Q000187:drug effects; D007773:Lactates / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D011299:Prenylamine / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects*; D014268:Trifluoperazine / Q000494:pharmacology
D002147:Calmodulin; D007093:Imidazoles; D007473:Ion Channels; D007773:Lactates; D011950:Receptors, Cholinergic; D014268:Trifluoperazine; C031938:calmidazolium; C053347:prenylamine lactate; D011299:Prenylamine; D000109:Acetylcholine; D002746:Chlorpromazine; D004121:Dimethyl Sulfoxide