Characterization of the gene-product of the Steel locus.
Steel factor (SLF) (aka: mast cell growth factor, stem cell factor, kit ligand) is the product of the murine Steel locus on chromosome 10 and is a ligand for the c-kit protooncogene. Isolation of cDNAs for SLF revealed that it was a membrane bound growth factor. Proteolytic processing releases a soluble version of the growth factor which has been shown to promote a wide variety of biological functions. In this review we focus on the cellular and molecular biology of SLF.
Williams
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DE
Department of Experimental Hematology (DEW), Immunex Research and Development Corporation, Seattle, WA 98101.
Lyman
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SD
D000483:Alleles; D000818:Animals; D016298:Hematopoietic Cell Growth Factors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008407:Mast Cells / Q000502:physiology; D009154:Mutation / Q000235:genetics; D019089:Stem Cell Factor; D013234:Stem Cells / Q000502:physiology
D016298:Hematopoietic Cell Growth Factors; D019089:Stem Cell Factor