HLA antigens and Vogt-Koyanagi-Harada's disease.
Thirty patients with Vogt-Koyanagi-Harada's disease were typed for HLA-A and HLA-B antigenic determinants by a microlymphocytotoxicity technique. HLA-B22 antigen showed an increased frequency of 43.3% in the patient group (relative risk = 8.69; exact P < 0.0001; corrected P < 0.0025) compared with normal control group (frequency = 7.69%). This association suggests that immunogenetic factor may play an important role in the pathogenesis of Vogt-Koyanagi-Harada's disease.
Yu
Q
Q
Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
Mao
W
W
Xie
C
C
Li
S
S
D002681:China; D000939:Epitopes / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D014607:Uveomeningoencephalitic Syndrome / Q000276:immunology*
D000939:Epitopes; D015234:HLA-A Antigens; D015235:HLA-B Antigens