title: HLA antigens and Vogt-Koyanagi-Harada's disease.
abstract: Thirty patients with Vogt-Koyanagi-Harada's disease were typed for HLA-A and HLA-B antigenic determinants by a microlymphocytotoxicity technique. HLA-B22 antigen showed an increased frequency of 43.3% in the patient group (relative risk = 8.69; exact P < 0.0001; corrected P < 0.0025) compared with normal control group (frequency = 7.69%). This association suggests that immunogenetic factor may play an important role in the pathogenesis of Vogt-Koyanagi-Harada's disease.
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
authors.forename: W
authors.initials: W
authors.lastname: Mao
authors.forename: C
authors.initials: C
authors.lastname: Xie
authors.forename: S
authors.initials: S
authors.lastname: Li
mesh_terms: D002681:China; D000939:Epitopes / Q000032:analysis*; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006801:Humans; D014607:Uveomeningoencephalitic Syndrome / Q000276:immunology*
chemical_list: D000939:Epitopes; D015234:HLA-A Antigens; D015235:HLA-B Antigens