title: Reversible low-molecular-weight proteinuria in patients with distal renal tubular acidosis.
abstract: Four patients with untreated renal tubular acidosis had a urinary excretion of low-molecular-weight (LMW) proteins which was restored to normal by alkali therapy. Hypokalaemic proximal tubular damage in untreated patients with distal renal tubular acidosis is believed to be the cause of LMW proteinuria. An examination of urinary excretion of LMW proteins is useful for determining hypokalaemic proximal tubular dysfunction, as well as the efficiency of alkali therapy.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Igarashi
authors.forename: H
authors.initials: H
authors.lastname: Kawato
authors.forename: S
authors.initials: S
authors.lastname: Kamoshita
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000141:Acidosis, Renal Tubular / Q000150:complications*; D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D011188:Potassium / Q000097:blood; D011507:Proteinuria / Q000175:diagnosis* / Q000209:etiology; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D000511:alpha-Macroglobulins; D003404:Creatinine; D000118:Acetylglucosaminidase; D011188:Potassium