title: Definition of platelet-derived histamine-releasing factor and histaminergic receptors modulating platelet aggregation.
abstract: Endogenous and exogenous free radical scavengers significantly decrease mast cell histamine release induced by coincubation with resting, activated platelets or with platelet-derived supernatant. Histamine and pyridylethylamine dose-dependently enhance platelet aggregation; the effect is potentiated by ranitidine and blocked by mepyramine. Histamine increases also cytosolic calcium concentration in platelets stimulated with thrombin, and binding sites for [3H]-mepyramine are present on platelet membranes.
authors.affiliation: Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
authors.forename: P F
authors.initials: PF
authors.lastname: Mannaioni
authors.forename: A
authors.initials: A
authors.lastname: Pistelli
authors.forename: F
authors.initials: F
authors.lastname: Gambassi
authors.forename: M G
authors.initials: MG
authors.lastname: Di Bello
authors.forename: S
authors.initials: S
authors.lastname: Raspanti
authors.forename: E
authors.initials: E
authors.lastname: Masini
mesh_terms: D001792:Blood Platelets / Q000737:chemistry / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D005609:Free Radicals; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation; D011968:Receptors, Histamine / Q000502:physiology*
chemical_list: D005609:Free Radicals; D011968:Receptors, Histamine; D002118:Calcium