Dietary fluoride prevents phosphorus-induced nephrocalcinosis in female rats.
The effect of dietary fluoride (F) on nephrocalcinosis was studied in young, female rats. Nephrocalcinosis was induced by a diet rich in phosphorus (P). F in the diet effectively counteracted P-induced nephrocalcinosis in a dose-dependent fashion. The feeding of increasing amounts of F caused decreasing calcium (Ca) and F concentrations in kidney. This suggests that the amount of Ca in kidney determines F accumulation in this organ, rather than F intake. Increasing amounts of F in the diet caused increasing rates of urinary and fecal excretion and whole-body retention of F. Dietary F did not influence urinary and fecal excretion and plasma concentrations of Ca, magnesium (Mg), and P. The metabolic basis for the protective effect of F against the development of nephrocalcinosis remains to be established.
Grooten
H N
HN
Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
Ritskes-Hoitinga
J
J
Mathot
J N
JN
Lemmens
A G
AG
Beynen
A C
AC
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D005260:Female; D005459:Fluorides / Q000494:pharmacology*; D007668:Kidney / Q000737:chemistry / Q000473:pathology; D008274:Magnesium / Q000378:metabolism; D009397:Nephrocalcinosis / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control*; D010758:Phosphorus / Q000378:metabolism; D016226:Phosphorus, Dietary / Q000037:antagonists & inhibitors*; D051381:Rats
D016226:Phosphorus, Dietary; D010758:Phosphorus; D008274:Magnesium; D005459:Fluorides; D002118:Calcium