title: Effects of clomipramine on the concentrations of catecholamines, indoleamines and their metabolites in 11 rat brain regions.
abstract: The effects of clomipramine (CMP) treatment on the brain concentrations of catecholamines, indoleamines and their metabolites were evaluated in 11 rat brain regions. An acute CMP treatment (15 mg/kg) reduced only the 5-hydroxyindole-3-acetic acid (5HIAA) concentrations in all regions. A long-term CMP treatment (14 days, 10 mg/kg/day) decreased the concentrations of dopamine (DA), 5-hydroxytryptamine and 5HIAA in the mesencephalon, and increased the DA concentrations in the hippocampus. In comparison with the values for the long-term treated rats, an acute injection of CMP (15 mg/kg) after a long-term treatment increased the norepinephrine concentrations in the hypothalamus and amygdala, and the concentrations of DA, 3,4-dihydroxyphenylacetic acid and homovanillic acid in the basal ganglia. On the other hand, it failed to decrease the 5HIAA concentrations in the basal ganglia, frontal cortex, hypothalamus, cerebellum, pons + medulla oblongata, and mesencephalon.
authors.affiliation: Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kido
authors.forename: M
authors.initials: M
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
authors.forename: N
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Kurata
authors.forename: M
authors.initials: M
authors.lastname: Kurachi
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000032:analysis*; D002997:Clomipramine / Q000494:pharmacology*; D004867:Equipment Design; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis / Q000378:metabolism; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D014018:Tissue Distribution
chemical_list: D002395:Catecholamines; D006897:Hydroxyindoleacetic Acid; D002997:Clomipramine