Quantification of the predictivity of some short-term assays for carcinogenicity in rodents.
A statistical procedure is described for assessing the predictive performance of short-term tests for carcinogenicity in which the actual number of chemicals tested is taken into consideration. The method is then applied to several widely used short-term assays.
Klopman
G
G
Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106.
Rosenkranz
H S
HS
D000818:Animals; D015197:Carcinogenicity Tests / Q000706:statistics & numerical data*; D002273:Carcinogens / Q000633:toxicity*; D002869:Chromosome Aberrations; D004261:DNA Replication / Q000187:drug effects; D016208:Databases, Factual; D008433:Mathematics; D009152:Mutagenicity Tests / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D012377:Rodentia; D012486:Salmonella typhimurium / Q000187:drug effects
D002273:Carcinogens