Correlation between in vitro cytokine production and clinical evolution of multiple sclerosis patients.
In this preliminary study we demonstrated that cytokine production by short whole blood PHA stimulated culture is correlated with clinical evolution of MS patients. The TNF alpha production could forewarn the physician of a new relapse.
Chofflon
M
M
Juillard
C
C
Gauthier
G
G
Grau
G E
GE
D001379:Azathioprine / Q000008:administration & dosage; D002478:Cells, Cultured; D003520:Cyclophosphamide / Q000008:administration & dosage; D016207:Cytokines / Q000096:biosynthesis*; D006801:Humans; D015592:Immunoradiometric Assay; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D008137:Longitudinal Studies; D009000:Monocytes / Q000276:immunology; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D012008:Recurrence; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D003520:Cyclophosphamide; D001379:Azathioprine