[Mechanism of the antimutagenic effect of interferon in human fibroblasts based on induced protein analysis].
Proteins induced in human fibroblasts after treatment of some antimutagens (interferon, p-aminobenzoic acid, heating and vaccinia virus infection) were identified by means of polyacrylamide gel electrophoresis (10-15%) followed by fluorography of the gel. Influenza virus proteins (A/WSN/33) were used as markers to determine the molecular weights of the new proteins. The results obtained suggest that interferon, p-aminobenzoic acid, heating and vaccinia virus infection induced proteins with mol. weights of 24 and 18 kD except the protein with 76 kD observed only after heating insult.
Gubitskaia
E G
EG
Tashenova
A A
AA
Sinel'shchikova
T A
TA
Akhmatullina
N B
NB
Zasukhina
G D
GD
D010129:4-Aminobenzoic Acid / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D006358:Hot Temperature; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008970:Molecular Weight; D016296:Mutagenesis / Q000187:drug effects*; D010779:Photofluorography; D014176:Protein Biosynthesis; D011506:Proteins / Q000187:drug effects; D014616:Vaccinia virus / Q000502:physiology*
D011506:Proteins; D007372:Interferons; D010129:4-Aminobenzoic Acid
K mekhanizmu antimutagennogo deĭstviia interferona v fibroblastakh cheloveka na osnove analiza indutsirovannykh belkov.