Congenital heart block: successful prophylactic treatment with intravenous gamma globulin and corticosteroid therapy.
In mothers with anti-Ro-positive antibodies whose previous pregnancies have ended in deliveries of infants with congenital heart block, prophylactic therapeutic strategies are used to try to diminish the production and passage into fetal circulation of autoantibodies. Intravenous gamma globulin was given at 14 and 18 weeks' gestation and prednisone was given from 14 weeks' gestation to a woman with Sjögren's syndrome. The pregnancy ended with delivery of an infant without congenital heart block.
Kaaja
R
R
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Julkunen
H
H
Ammälä
P
P
Teppo
A M
AM
Kurki
P
P
D000328:Adult; D000653:Amniotic Fluid / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005315:Fetal Diseases / Q000517:prevention & control*; D006327:Heart Block / Q000151:congenital / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D007118:Immunoassay; D007275:Injections, Intravenous; D011241:Prednisone / Q000627:therapeutic use*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012203:Rh Isoimmunization / Q000150:complications / Q000188:drug therapy; D012859:Sjogren's Syndrome / Q000150:complications / Q000276:immunology; D005719:gamma-Globulins / Q000627:therapeutic use*
D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; D005719:gamma-Globulins; D011241:Prednisone