Evidence for an HIV-1 mediated suppression of in vitro growth of enriched (CD34+) hematopoietic progenitors.
The effect of HIV-1 on the in vitro growth of CD34+ cells, purified from bone marrow of normal donors, was studied. HIV-1 treated CD34+ cells exhibited a progressive and significant decrease of cell viability in liquid cultures and a reduced percentage of committed progenitors in the absence of viral infection. The same results were obtained treating CD34+ cell cultures with recombinant gp 120 alone. These results point to a direct cytotoxic activity of gp120 for CD34+ cells.
Zauli
G
G
Institute of Microbiology, University of Bologna, Italy.
Re
M C
MC
Furlini
G
G
Giovannini
M
M
La Placa
M
M
D015703:Antigens, CD / Q000032:analysis*; D018952:Antigens, CD34; D002455:Cell Division; D002470:Cell Survival; D002478:Cells, Cultured; D015699:HIV Envelope Protein gp120 / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D011994:Recombinant Proteins / Q000502:physiology
D015703:Antigens, CD; D018952:Antigens, CD34; D015699:HIV Envelope Protein gp120; D011994:Recombinant Proteins