title: Lack of effect of verapamil on diurnal and thyrotropin releasing hormone stimulated thyrotropin levels in man.
abstract: We have evaluated the effects of oral administration of the calcium blocker verapamil on the pituitary secretion of TSH. Verapamil was administered 120 mg tid to 6 healthy volunteers. Plasma TSH was measured with an ultrasensitive immunoradiometric assay. TSH secretion was assessed by a 24-hour profile of unstimulated plasma concentrations and by the effect of TRH stimulation before and after 7 days of verapamil administration. No effects of verapamil was found on either basal or stimulated secretion of TSH.
authors.affiliation: Department of Clinical Chemistry, Randers General Hospital, County of Aarhus, Denmark.
authors.forename: J E
authors.initials: JE
authors.lastname: Nielsen-Kudsk
authors.forename: P D
authors.initials: PD
authors.lastname: Bartels
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013974:Thyroxine / Q000097:blood; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D014700:Verapamil; D013974:Thyroxine