Effects of d- and dl-chlorpheniramine on serotonin and 5-hydroxyindoleacetic acid levels in the regional parts of rat brain.
The purpose of this study was to further investigate the effects of chlorpheniramine (d- and dl-forms) on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the regional parts of rat brain. After the intravenous administration of each form of chlorpheniramine, the 5-HT and 5-HIAA levels were measured by HPLC system. Each form of chlorpheniramine is effective in reducing 5-HIAA, but not 5-HT levels in most of the regional brain of rats. The degree of reducing 5-HIAA levels does not correlate with the antihistaminic potency of these drugs. Our previous results showed that chlorpheniramine reduced the 3,4-dihydroxyphenylacetic acid levels, but not the dopamine levels in the brain of rats. Taken together, these findings raise problems regarding possible physiological and behavioral effects by using chlorpheniramine as a histamine H1-blocker in animal experiments.
Sakurai
E
E
Department of Pharmaceutics I, Tohoku College of Pharmacy, Sendai, Japan.
Yamasaki
S
S
Hikichi
N
N
Onodera
K
K
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000737:chemistry; D002744:Chlorpheniramine / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008032:Limbic System / Q000737:chemistry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D013237:Stereoisomerism
D012701:Serotonin; D002744:Chlorpheniramine; D006897:Hydroxyindoleacetic Acid