Oxidative damage and changes in the glutathione redox system in erythrocytes from rats treated with hexachlorocyclohexane.
The concentration of reduced glutathione in the erythrocytes of rats was significantly decreased 24-72 hr after the rats were treated with 300 mg commercial hexachlorocyclohexane/kg body weight (one-third of the LD50), given ip. The activities of glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase were also significantly decreased 24 hr after treatment but there was no change in glutathione peroxidase activity. The results suggest that hexachlorocyclohexane produces significant changes in the glutathione redox system of rat erythrocytes leading to oxidative membrane damage.
Agrawal
D
D
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Sultana
P
P
Gupta
G S
GS
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000097:blood / Q000187:drug effects; D005978:Glutathione / Q000097:blood*; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects; D005980:Glutathione Reductase / Q000097:blood / Q000187:drug effects; D005982:Glutathione Transferase / Q000097:blood / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats
D001556:Hexachlorocyclohexane; D005954:Glucosephosphate Dehydrogenase; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D005978:Glutathione