Retinoic acid potentiates the neurotrophic but not the mitogenic action of the class 1 heparin-binding growth factor (HBGF-1).
Retinoic acid promotes the neuronal survival properties of the class 1 heparin-binding growth factor (HBGF-1) on 8-day-old chick ciliary and sensory neurones. It has little or no effect on the survival promoting properties of class 2 heparin-binding growth factor (HBGF-2) on these cell types. Nerve growth factor (NGF) promoted survival of sympathetic and sensory neurones, and was unaffected at any concentration of retinoic acid. The mitogenic effect of both HBGF-1 and HBGF-2 was unaltered at any concentration of retinoic acid. It is suggested that naturally occurring gradients of retinoic acid, for example, as occur in the developing limb bud, could have a role in the development of normal innervation patterns through selective interaction with neurotrophic molecules.
Hendry
I A
IA
Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra.
Belford
D A
DA
D000818:Animals; D002455:Cell Division; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D004357:Drug Synergism; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology*; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D008934:Mitogens / Q000494:pharmacology*; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000166:cytology / Q000187:drug effects; D014212:Tretinoin / Q000494:pharmacology*
D008934:Mitogens; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D016220:Fibroblast Growth Factor 1; D014212:Tretinoin