title: [Neonatal alloimmune thrombocytopenia--can cryopreserved thrombocytes help? (Case report)].
abstract: We present a case report of the transfusion of cryopreserved HPA 1-negative platelets to a newborn suffering from neonatal alloimmune thrombocytopenia (NAT). A boy weighing 3450 g, born of a HPA1-negative mother with a platelet count of 9 Gpt/l after delivery, received two transfusions of cryopreserved HPA1-negative platelet concentrates. The first transfusion resulted in a platelet increment to 32 Gpt/l (CCI 11). A second transfusion was needed after a further drop of the platelet count on day 4 to 18 Gpt/l, resulting in an increment to 64 Gpt/l (CCI 36). Normal development during the first six months was obtained. In our opinion, cryopreserved HPA1-negative platelets could be helpful in the therapeutical strategy of NAT.
authors.affiliation: Institut für Transfusiologie und transplantologie, Humboldt-Universität zu Berlin.
authors.forename: E
authors.initials: E
authors.lastname: Richter
authors.forename: H
authors.initials: H
authors.lastname: Weigel
authors.forename: D
authors.initials: D
authors.lastname: Barz
authors.forename: K P
authors.initials: KP
authors.lastname: Krause
authors.forename: G
authors.initials: G
authors.lastname: Matthes
mesh_terms: D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D016913:Blood Component Transfusion; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010976:Platelet Count; D011247:Pregnancy; D013921:Thrombocytopenia / Q000276:immunology / Q000628:therapy*
chemical_list: D016824:Antigens, Human Platelet
vernacular_title: Neonatale Alloimmunthrombozytopenie (NAT)--können kryokonservierte Thrombozyten helfen? (Falldemonstration).