Changes in metabolism induced by oral contraceptives containing desogestrel and gestodene in older women.
Forty women aged 35-45 years were investigated to determine changes in haemostasis, lipids and lipoproteins whilst taking combined contraceptive pills containing the new third generation progestogens, desogestrel and gestodene. There was no statistically significant difference between the two preparations in any of the parameters studied. Women taking the combined pill showed increases in fibrinogen and factor X and a reduction in antithrombin III when compared with their control values. There were also small but significant increases in triglycerides and triglyceride-rich lipoproteins. Total high density lipoprotein cholesterol (HDL), high density lipoprotein-2 cholesterol (HDL2), high density lipoprotein-3 cholesterol (HDL3) and apolipoprotein A-1 were all increased at some stages of the treatment cycle, whereas low density lipoprotein cholesterol (LDL) showed a reduction in the first cycle of treatment. The changes in lipids and lipoproteins would not appear to increase the risk of cardiovascular disease, however the effects of the increase in the pro-coagulant factors are uncertain.
Robinson
G E
GE
Margaret Pyke Centre for the Study and Training of Family Planning, London.
Bounds
W
W
Mackie
I J
IJ
Stocks
J
J
Burren
T
T
Machin
S J
SJ
Guillebaud
J
J
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D001053:Apolipoproteins / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D017135:Desogestrel; D005167:Factor VII / Q000378:metabolism; D005170:Factor X / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism*; D008875:Middle Aged; D009652:Norpregnenes / Q000008:administration & dosage; D010958:Plasminogen / Q000378:metabolism; D011486:Protein C / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D001053:Apolipoproteins; D001779:Blood Coagulation Factors; D003277:Contraceptives, Oral, Combined; D008074:Lipoproteins; D009652:Norpregnenes; D011486:Protein C; D014280:Triglycerides; D000511:alpha-Macroglobulins; C024668:plasmin-alpha(2)-macroglobulin complex; C033273:Gestodene; D017135:Desogestrel; D000990:Antithrombin III; D005167:Factor VII; D005170:Factor X; D005340:Fibrinogen; D010958:Plasminogen; D002784:Cholesterol; D005341:Fibrinolysin