Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits.
The present study deals with the effects of immunomodulators on the morphology of intracerebral arterial walls in rabbits with experimental subarachnoid haemorrhage (SAH). Immunostimulators:thymostimuline and inosine dimethylamino-isopropanol-p-acetamido-benzoate were found to aggravate the angiopathic changes, whereas immunosuppressive drugs-cyclosporine A and azathioprine appeared to prevent the damage. The authors consider the possibility of using immunosuppressive drugs in patients with ruptured intracranial aneurysms.
Ryba
M
M
Department of Neurophysiology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
Iwańska
K
K
Walski
M
M
Pastuszko
M
M
D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use*; D002536:Cerebral Arteries / Q000187:drug effects* / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D007542:Inosine Pranobex / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000188:drug therapy*; D013949:Thymus Extracts / Q000627:therapeutic use
D003524:Cyclosporins; D013949:Thymus Extracts; C031407:thymostimulin; D001379:Azathioprine; D007542:Inosine Pranobex