[Activity of elastase-like proteinases and their inhibitors in indigent nearly healthy residents in various biogeochemical conditions of the Chuvash ASSR].
A proteinase-inhibitory balance of blood (elastase-like activity, alpha 1-proteinase inhibitor and alpha 2-macroglobulin activities) was studied in practically healthy inhabitants of the Chuvash ASSR two subregions--Sura river basin and Cubninocivil region, which are distinctly dissimilar in all the biogeochemical parameters involving macro- and microtrace compositions. The higher activity of elastase-like proteinases and decreased content of alpha 1-proteinase inhibitor were detected in practically healthy inhabitants of the river Sura basin, where high incidence of myocardial infarction was found, as compared with those of the Cubninocivil people. The similar alterations in the proteinase-inhibitory balance were observed in blood of experimental animals maintained on a diet containing fresh water from these subregions. The data obtained suggest that there exists causative relationship between biogeochemical parameters and development of imbalance in the proteinase-inhibitor system in practically healthy inhabitants of the river Sura basin. This imbalance is considered as a pathogenetic factor responsible for development of atherosclerosis.
Stepanov
R V
RV
Platonova
L V
LV
Suslikov
V L
VL
Paskhina
T S
TS
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000097:blood*; D014881:Water Supply / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D010196:Pancreatic Elastase
Aktivnost' élastazopodobnykh proteinaz i ikh ingibitorov u korennykh prakticheski zdorovykh zhiteleĭ v raznykh biogeokhimicheskikh usloviiakh Chuvashskoĭ ASSR.