[Monoclonal antibodies against determinants on human MHC class II antigens].
Monoclonal antibodies against different non-polymorphic determinants of HLA class II antigens are described. The epitopes are present on HLA-DR and HLA-DQ gene products as detected by monoclonal antibody BL-Ia/l, and at HLA-DR and HLA-DP gene products which are recognized by monoclonal antibody BL-Ia/4. Another epitope recognized by the monoclonal antibody BL-Ia/DQ is only found on DQ molecules. The monoclonal antibodies BL-Ia/1, BL-Ia/4, and BL-Ia/5 are directed against the beta-subunit of 29 kDa/35 kDa class II heterodimer molecules. The recognized epitopes are shown to be not dependent on the association of the alpha- and beta-chains.
Eichler
W
W
Bereich Tierphysiologie und Immunbiologie, Karl-Marx-Universität Leipzig.
Seifert
M
M
Fiebig
H
H
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D015180:Electrophoresis, Gel, Two-Dimensional; D000939:Epitopes; D005434:Flow Cytometry; D006681:HLA-D Antigens / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007526:Isoelectric Point; D008285:Major Histocompatibility Complex; D008970:Molecular Weight; D011233:Precipitin Tests
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006681:HLA-D Antigens
Monoklonale Antikörper gegen Determinanten humaner MHC-Klasse II-Antigene.