[Effect of the stable prostacyclin analog Iloprost on enzyme release during extracorporeal kidney perfusion].
The influence of the stable prostacyclin-analogue Iloprost (Fa. Schering, Berlin) in the enzyme release from extracorporalic perfused kidneys was tested in an experimental investigation. The mechanic hypothermic perfusion was carried out on four different conditions. The estimation of specially cytosolic, lysosomal, and membrane-associated enzymes in the perfusat of the kidneys showed less activities in the Iloprost-protected kidneys. The results after the replantation of the kidneys support the interpretation of the enzyme determinations.
Schabel
J
J
Universitätsklinik und Poliklinik für Urologie, Bereichs Medizin, Martin-Luther-Universität Halle-Wittenberg.
Hütter
H J
HJ
Pauer
H D
HD
Rebmann
U
U
Forth
H J
HJ
Heynemann
H
H
Mehlhorn
G
G
D000135:Acid Phosphatase / Q000378:metabolism; D000581:Amidohydrolases / Q000378:metabolism; D000626:Aminopeptidases / Q000378:metabolism; D000818:Animals; D018826:CD13 Antigens; D002462:Cell Membrane / Q000201:enzymology; D003080:Cold Temperature; D003600:Cytosol / Q000201:enzymology; D004798:Enzymes / Q000378:metabolism*; D016285:Iloprost / Q000494:pharmacology*; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D010477:Perfusion; D012044:Regression Analysis; D013552:Swine; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D004798:Enzymes; D005723:gamma-Glutamyltransferase; D000135:Acid Phosphatase; D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; D018826:CD13 Antigens; D000581:Amidohydrolases; C019665:amidase; D016285:Iloprost
Die Wirkung des stabilen Prostazyklin-Analogons Iloprost auf die Enzymfreisetzung während der extrakorporalen Nierenperfusion.