The regulation of antibody responses by mini-cytokines.
The presence of adrenocorticotropic hormone (ACTH) and substance P (SP) receptors on leukocytes is suggestive that these cells can respond to these ligands. To address this possibility, we have investigated the consequences of ACTH and SP stimulation of B cells. As a result, enhanced immunoglobulin synthesis mimicking an IL-4-like mechanism was noted. Importantly, this stimulation could be induced at ligand concentrations at or near the kD for their receptors. Herein these effects by ACTH and SP were described using B cell lymphoma cell lines and normal B cells.
Pascual
D W
DW
Department of Microbiology, University of Alabama, Birmingham.
Bost
K L
KL
Xu-Amano
J
J
Kiyono
H
H
McGhee
J R
JR
D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects / Q000502:physiology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D016207:Cytokines / Q000502:physiology*; D006801:Humans; D051379:Mice; D015213:Neuroimmunomodulation / Q000502:physiology*; D013373:Substance P / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology
D016207:Cytokines; D013373:Substance P; D000324:Adrenocorticotropic Hormone