title: Nitrendipine efficacy and safety in patients with mild and moderate essential hypertension.
abstract: The antihypertensive effect of nitrendipine was examined in 29 outpatients with a mild or moderate hypertension and type II diabetes or a dyslipidemic condition. The drug was administered for 90 days at a daily dose of 10 to 40 mg. Following a washout period, the blood pressure (measured by a Dinamap device) was 181/99 mm Hg supine and 172/104 mm Hg standing. Nitrendipine caused a reduction in both pressures and after 90 days their values were 148/74 and 143/80 mm Hg, respectively. Heart rate was not affected by the drug, which also caused no variation in blood pressure, total and HDL cholesterol, and triglycerides. In more than 20% of the cases, treatment was associated with headache and flushing, which did not necessitate discontinuation of treatment. Thus, nitrendipine is an effective antihypertensive agent and causes no untoward metabolic effects.
authors.affiliation: III Divisione Medicina, O.V.E., U.S.L. 35, Catania, Italy.
authors.forename: M M
authors.initials: MM
authors.lastname: Di Salvo
authors.forename: P M
authors.initials: PM
authors.lastname: Finocchiaro
authors.forename: M
authors.initials: M
authors.lastname: Bonaccorso
authors.forename: L
authors.initials: L
authors.lastname: Attanasio
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D009568:Nitrendipine