Parathyroid hormone fragment 1-34 inhibits drug-induced inflammation in various experimental models.
We investigated the effect of the administration of rat parathyroid hormone-(1-34) on acute or chronic inflammatory processes in different experimental animal models. Fragment 1-34 of parathyroid hormone had an inhibitory effect in all inflammatory acute tests. The dose-response experiments showed that the maximal anti-inflammatory and anti-exudative effects appeared at the dose of 3.30 and 0.33 micrograms/kg, respectively. The anti-inflammatory effect was observed in the first phase of the inflammatory process. In the carrageenin-induced edema test the anti-inflammatory activity began to decline after 180 min. In contrast, this peptide was inactive in the inflammatory chronic test we used.
Caruso
A
A
Institute of Pharmacology, University of Catania, School of Medicine, Italy.
Amico-Roxas
M
M
Cutuli
V
V
Prato
A
A
Fiore
C E
CE
Clementi
G
G
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000503:physiopathology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009761:Nystatin; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D010538:Peritonitis / Q000139:chemically induced / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin; D013373:Substance P; D019379:Teriparatide
D000085:Acetates; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D019379:Teriparatide; D009761:Nystatin; D012701:Serotonin; D013373:Substance P; D002351:Carrageenan; D019342:Acetic Acid