[Effect of gentamicin on the concentration of calcium, magnesium and zinc in perilymph of the guinea pig].
The calcium, magnesium and zinc ions in perilymph of the guinea pig were measured after hearing loss induced by gentamicin. The concentration of the calcium ions and magnesium ions increased, the zinc ions decreased in perilymph. The ototoxicity of gentamicin was related to the changes of these electrolytes in inner ear circumstance. The results showed that the changes of ions were the step of gentamicin ototoxicity.
Deng
Y
Y
Gulou Hospital, Nanjing University Medical School.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005839:Gentamicins / Q000009:adverse effects*; D006168:Guinea Pigs; D006312:Hearing Loss, Bilateral / Q000139:chemically induced / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects; D008274:Magnesium / Q000378:metabolism; D010498:Perilymph / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D005839:Gentamicins; D007473:Ion Channels; D008274:Magnesium; D015032:Zinc; D002118:Calcium