title: On the superposition of currents from ion channels.
abstract: We derive a number of statistical properties of the superposition of several independent channels contributing to a patch-clamp recording. Failure of these properties indicates dependence of the channels and may suggest the nature of interactions. We show how properties such as dwell-time distributions of the individual channels may be determined from those of the superposition in the case that the channels are independent.
authors.affiliation: Department of Physics, University of California, San Diego, La Jolla 92093.
authors.forename: D R
authors.initials: DR
authors.lastname: Fredkin
authors.forename: J A
authors.initials: JA
authors.lastname: Rice
mesh_terms: D000818:Animals; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D008954:Models, Biological; D011336:Probability
chemical_list: D007473:Ion Channels