The human renin gene in transgenic mice.
We have obtained three transgenic mouse lines carrying the human renin gene. All three lines have been shown to transmit the introduced human gene to progeny. In the present study, we have demonstrated that the human renin gene was expressed and correctly spliced in the kidneys of both transgenic parents and progeny.
Seo
M S
MS
Institute of Applied Biochemistry, University of Tsukuba, Japan.
Fukamizu
A
A
Nomura
T
T
Yokoyama
M
M
Katsuki
M
M
Murakami
K
K
D000818:Animals; D015152:Blotting, Northern; D015139:Blotting, Southern; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D012083:Renin / Q000235:genetics*
D012083:Renin