title: Pentagastrin-stimulated histamine release and acid secretion from the totally isolated vascularly perfused rat stomach.
abstract: This study was performed to examine the effect of cAMP levels on histamine release in the isolated rat stomach. Pentagastrin-induced histamine release was unaffected by phosphodiesterase inhibition, and pentagastrin itself had no phosphodiesterase-like effect. The results support previous observations showing that histamine is likely to be the mediator of the acid secretagogue effect of (penta) gastrin.
authors.affiliation: Department of Medicine, University Hospital, Trondheim, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Iwasa
authors.forename: A K
authors.initials: AK
authors.lastname: Sandvik
authors.forename: H L
authors.initials: HL
authors.lastname: Waldum
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D006632:Histamine; D010418:Pentagastrin; D015056:1-Methyl-3-isobutylxanthine