Biological low-dose radiation effects.
It is theorized that biological responses to ionizing radiation in the low dose range are determined according to a doubly dichotomous pattern. Energy depositions fall into 2 categories: events at thermal energy levels where they may be experienced by cells as rates even at background exposure conditions, and events at energy levels of the order of 10-100 eV where damage to DNA may be caused. Variations in background exposure intensity may or may not lead preemptively to changes in the cell's capacity for response to radiation damage. High-level energy depositions lead post hoc to an initial stabilizing reaction largely leading to the fixation of the initial DNA damage, and to a subsequent restorative or palliative repair process. This model entails reinterpretation of some experimental results. The model has implications for the relationship between scientific analysis of low-dose effects and the regulatory needs for simplicity and homogeneity in risk evaluation. This represents a new challenge for the acceptability of radiation protection norms.
Oftedal
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Division of General Genetics, University of Oslo, Norway.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D002648:Child; D002657:Child Development / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology; D009664:Norway / Q000453:epidemiology; D011835:Radiation Protection / Q000592:standards; D051381:Rats; D013964:Thyroid Neoplasms / Q000453:epidemiology