Antiproliferative function of glia maturation factor beta.
Recombinant human glia maturation factor beta (GMF-beta) reversibly inhibits the proliferation of neoplastic cells in culture by arresting the cells in the G0/G1 phase. This phenomenon is not target-cell specific, as neural and nonneural cells are equally inhibited. When tested simultaneously, GMF-beta suppresses the mitogenic effect of acidic fibroblasts growth factor (aFGF), but the two are synergistic in promoting the morphologic differentiation of cultured astrocytes. GMF-beta also counteracts the growth-stimulating effect of pituitary extract and cholera toxin on Schwann cells. The results underscore the regulatory role of GMF-beta and its intricate interaction with the mitogenic growth factors.
Lim
R
R
Department of Neurology, University of Iowa College of Medicine, Iowa City.
Zhong
W X
WX
Zaheer
A
A
D000818:Animals; D001253:Astrocytes / Q000166:cytology* / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D002478:Cells, Cultured; D004357:Drug Synergism; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology; D020904:Glia Maturation Factor; D006131:Growth Inhibitors / Q000494:pharmacology*; D007700:Kinetics; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology*; D012583:Schwann Cells / Q000166:cytology* / Q000187:drug effects
D020904:Glia Maturation Factor; D006131:Growth Inhibitors; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins; D016220:Fibroblast Growth Factor 1