Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep.
The changes in propionate metabolism that accompany cobalt deficiency in sheep are described. Two groups of sheep, fed either a cobalt sufficient or deficient diet, were given an iv propionate load at intervals during a 14 w experiment. There was a tendency towards increased propionate half-life as the animals became cobalt deficient. However, significant changes in the area under the plasma methylmalonic acid-time curve occurred very early, indicating significant impairment of propionate metabolism. Despite this, the area under the plasma glucose-time curve was unaffected by cobalt deficiency, suggesting that the impairment of propionate metabolism, although significant, is not extensive.
Kennedy
D G
DG
Veterinary Research Laboratories, Belfast Northern Ireland, UK.
O'Harte
F P
FP
Blanchflower
W J
WJ
Rice
D A
DA
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003035:Cobalt / Q000172:deficiency*; D006207:Half-Life; D008764:Methylmalonic Acid / Q000378:metabolism; D011422:Propionates / Q000378:metabolism*; D012756:Sheep; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000378:metabolism*
D001786:Blood Glucose; D011422:Propionates; D003035:Cobalt; D008764:Methylmalonic Acid; D014805:Vitamin B 12