title: [In situ and invasive cancer of the gallbladder: nucleolar organizer regions].
abstract: We studied samples from gallbladders of 10 subjects with invasive and 10 with in situ carcinoma of this organ. The number of nucleolar organizer regions, as revealed by colloidal silver staining, was at least 4 times larger in cancer samples than in control ones. Mean number of nucleolar organizer regions for invasive lesions was higher than for in situ ones (11.6 +/- 2.3 vs 9.4 +/- 1.3, p less than 0.04). The study of cellular markers may be helpful in establishing the preneoplastic nature of gallbladder lesions.
authors.affiliation: Departamento de Cirugía, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.
authors.forename: I
authors.initials: I
authors.lastname: Roa
authors.forename: J C
authors.initials: JC
authors.lastname: Araya
authors.forename: I
authors.initials: I
authors.lastname: Wistuba
authors.forename: X
authors.initials: X
authors.lastname: De Aretxabala
authors.forename: A
authors.initials: A
authors.lastname: Mauriz
authors.forename: M
authors.initials: M
authors.lastname: Cea
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology*; D003102:Colloids; D005706:Gallbladder Neoplasms / Q000473:pathology*; D006801:Humans; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011230:Precancerous Conditions; D012834:Silver; D013194:Staining and Labeling
chemical_list: D003102:Colloids; D012834:Silver
vernacular_title: Cancer in situ e invasor de la vesicula biliar: regiones del organizador nucleolar.