The effects of selenium on gestation, fertility, and offspring in mice.
Supplementation of mice from 22 d old with the K-Selenocarrageenan (0.25 ppm Se) in drinking water reduced gestation period by 3.2 d. Selenium supplementation increased litter size by 53.8% and average litter weight by 5%. Continuous supplementation with selenium (0.25 ppm) of mice until the age of 50-56 d significantly increased the concentration of selenium and the glutathione peroxidase activity in whole blood and liver. In serum, fluorescent peroxidized lipid products were decreased by 22% and reducing sugar was decreased by 16% compared to unsupplemented controls. In whole blood of young mice, collagen was increased by 14%. IR differential spectra of whole blood show strong absorption at the acrylamide band, suggesting a role of selenium in preventing lipid peroxidation, as well as a stabilizing effect on blood proteins.
Tang
C C
CC
Research Centre for Eco-Environmental Sciences, Academia Sinica, Beijing, China.
Chen
H N
HN
Rui
H F
HF
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008098:Litter Size / Q000187:drug effects; D008297:Male; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*
D001798:Blood Proteins; D005979:Glutathione Peroxidase; D012643:Selenium