title: The induction of adipose conversion in 3T3-L1 cells is associated with early phosphorylation of a 60-kDa nuclear protein.
abstract: The induction of adipose conversion in 3T3-L1 cells by bezafibrate has been shown to be enhanced by dibutyryl-cAMP. We here report that the induction of adipose conversion in 3T3-L1 cells, by either bezafibrate and dibutyryl cAMP, or isobutylmethyxanthine alone, is associated with a very early phosphorylation of a 60-kDa acidic protein found in the nuclear fraction.
authors.affiliation: Department of Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Brandes
authors.forename: R
authors.initials: R
authors.lastname: Arad
authors.forename: J
authors.initials: J
authors.lastname: Bar-Tana
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004357:Drug Synergism; D015180:Electrophoresis, Gel, Two-Dimensional; D005347:Fibroblasts; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation
chemical_list: D009687:Nuclear Proteins; D003994:Bucladesine; D015056:1-Methyl-3-isobutylxanthine; D001629:Bezafibrate