The effect of cyclosporine on exocrine function of the rat pancreas--an in vitro study.
We have studied the effect of cyclosporine on the exocrine pancreas of rats submitted to treatment with different parenteral doses (15, 30, 50 mg/kg/day) for different time periods (7 and 30 days). Serum amylase levels, pancreas weight, and total pancreatic amylase and protein content showed a dose-dependent decrease. Basal amylase secretion from isolated lobules remained unchanged. Furthermore, the pancreatic lobules from animals under cyclosporine treatment exhibited a decreased response to bethanechol stimulation. Our data suggest that cyclosporine produces a toxic effect on exocrine pancreatic function.
López-Miranda
J
J
Departamento de Medicina Interna, Hospital Universitario Reina Sofia, Facultad de Medicina, Universidad de Córdoba, Spain.
Blanco-Molina
A
A
López-Segura
F
F
Nicolás-Puiggari
M
M
Torre-Cisneros
J
J
Pérez-Jiménez
F
F
D000681:Amylases / Q000378:metabolism*; D000818:Animals; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D003524:Cyclosporins / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D001626:Bethanechol Compounds; D003524:Cyclosporins; D011506:Proteins; D018723:Bethanechol; D000681:Amylases