title: An animal investigation into the effects of tympanostomy on middle ear mucociliary function and cilia.
abstract: The effect of tympanostomy on guinea-pig middle ear mucosa with particular reference to mucociliary function and cilia was investigated. 13 guinea-pigs were used; 5 acted as the control group with no surgical intervention whilst the other 8 had perforations made in one tympanic membrane. 6 weeks later an attempt was made to measure mucociliary function in all the ears, but this was unsuccessful. However, it would appear that fashioning a perforation in the tympanic membrane causes no histological changes in this animal model.
authors.affiliation: Department of Pathology, Medical School, University of Birmingham, UK.
authors.forename: L A
authors.initials: LA
authors.lastname: Smallman
authors.forename: S S
authors.initials: SS
authors.lastname: To
authors.forename: D W
authors.initials: DW
authors.lastname: Proops
mesh_terms: D000818:Animals; D002606:Charcoal; D002923:Cilia / Q000502:physiology / Q000648:ultrastructure; D004432:Ear, Middle / Q000033:anatomy & histology / Q000502:physiology*; D004848:Epithelium / Q000033:anatomy & histology / Q000502:physiology; D005064:Eustachian Tube / Q000033:anatomy & histology / Q000502:physiology; D006168:Guinea Pigs; D009079:Mucociliary Clearance / Q000502:physiology*; D010030:Ostomy; D011092:Polyethylene Glycols; D013194:Staining and Labeling; D014432:Tympanic Membrane / Q000601:surgery*
chemical_list: D002606:Charcoal; D011092:Polyethylene Glycols