title: The chicken GABAA receptor alpha 1 subunit: cDNA sequence and localization of the corresponding mRNA.
abstract: We report the sequence of a complementary DNA (cDNA) that encodes the chicken GABAA receptor alpha 1 subunit, which is extremely homologous to mammalian alpha 1 subunits. The distribution of alpha 1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the alpha 1 subunit may not necessarily be restricted to receptors having BZI pharmacology.
authors.affiliation: MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, U.K.
authors.forename: A N
authors.initials: AN
authors.lastname: Bateson
authors.forename: R J
authors.initials: RJ
authors.lastname: Harvey
authors.forename: W
authors.initials: W
authors.lastname: Wisden
authors.forename: T A
authors.initials: TA
authors.lastname: Glencorse
authors.forename: A A
authors.initials: AA
authors.lastname: Hicks
authors.forename: S P
authors.initials: SP
authors.lastname: Hunt
authors.forename: E A
authors.initials: EA
authors.lastname: Barnard
authors.forename: M G
authors.initials: MG
authors.lastname: Darlison
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D002642:Chick Embryo; D004247:DNA / Q000235:genetics*; D015723:Gene Library; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D011963:Receptors, GABA-A / Q000235:genetics*; D013462:Sulfur Radioisotopes
chemical_list: D046911:Macromolecular Substances; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D011963:Receptors, GABA-A; D013462:Sulfur Radioisotopes; D011061:Poly A; D012313:RNA; D004247:DNA