Late toxic effects of long-term exposure to lindane in peripheral blood cells in rabbits. II. Erythrocyte changes.
After lindane administration in daily doses of 0.1 LD50 for one month (total dose 2.0 LD50) changes in the erythrocytes were found persisting for up to 4 months after withdrawal of the pesticide. A significant increase in the number of echinocytes, a greater per cent of reticulocytes, significantly raised level of denatured haemoglobin, and an increased number of erythrocytes of higher sensitivity to oxidating factors in relation to control group was observed.
Grabarczyk
M
M
Department of Physiopathology, Institute of Haematology, Warszawa, Poland.
Woźniak
J
J
Podstawka
U
U
Kopeć-Szlezak
J
J
D000284:Administration, Oral; D000818:Animals; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D011817:Rabbits
D001556:Hexachlorocyclohexane