Enhanced expression of low molecular weight keratins during progressive diethylnitrosamine-induced hepatocarcinogenesis in rats is associated with the presence of high levels of gamma-glutamyl transpeptidase and glycogen-deficient islands.
The sequential expression of keratin proteins as a function of tumour progression was studied in the rat liver and compared with several tumour markers like histochemical gamma-glutamyl transpeptidase (GGT)-positive foci, quantitative GGT activity and glycogen deficient islands at corresponding stages using diethylnitrosamine (DEN) as a carcinogen. The enhanced expression of low molecular weight keratins indicating undifferentiated nature of the tumour is associated with the increased levels of tumour markers. The findings are discussed in relation to cytoskeletal alterations during progressive hepatocarcinogenesis in rats.
Fernandes
C
C
Carcinogenesis Division, Tata Memorial Centre, Bombay, India.
Rao
K V
KV
D000818:Animals; D014408:Biomarkers, Tumor; D002454:Cell Differentiation; D004052:Diethylnitrosamine / Q000494:pharmacology; D007633:Keratins / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011230:Precancerous Conditions / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D005723:gamma-Glutamyltransferase / Q000378:metabolism*
D014408:Biomarkers, Tumor; D008112:Liver Glycogen; D004052:Diethylnitrosamine; D007633:Keratins; D005723:gamma-Glutamyltransferase