Prevention of murine cerebral malaria by a stable prostacyclin analog.
Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.
Sliwa
K
K
Landesinstitut für Tropenmedizin Berlin, Germany.
Grundmann
H J
HJ
Neifer
S
S
Chaves
M F
MF
Sahlmüller
G
G
Blitstein-Willinger
E
E
Bienzle
U
U
Kremsner
P G
PG
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001927:Brain Diseases / Q000517:prevention & control*; D005260:Female; D016285:Iloprost / Q000627:therapeutic use*; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D008808:Mice, Inbred CBA; D010962:Plasmodium berghei / Q000276:immunology; D012333:RNA, Messenger / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
D000953:Antigens, Protozoan; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D016285:Iloprost