Late toxic effects of long-term exposure to lindane in peripheral blood cells in rabbits. I. Function impairment and structural disturbances in leucocytes.
Following lindane intoxication in daily doses of 0.1 LD50 during one month (total dose 2.0 LD50) functional changes were noted in granulocytes and structural changes in lymphocytes in peripheral blood of rabbits during 4 months after completion of lindane administration. A significant decrease of the phagocytic activity with a rise in the number of non-phagocytizing granulocytes, quantitative and qualitative changes of nucleoli and lysosomes were found in lymphocytes. The latest effect of lindane is regarded to be a raised number of non-phagocytizing granulocytes 4 months after withdrawal of the pesticide.
Kopeć-Szlezak
J
J
Department of Physiopathology, Institute of Haematology, Warszawa, Poland.
Szczepańska
I
I
Grabarczyk
M
M
Podstawka
U
U
D000284:Administration, Oral; D000818:Animals; D001772:Blood Cell Count; D006098:Granulocytes / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D008214:Lymphocytes / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits
D001556:Hexachlorocyclohexane