Reduction of neurotensin immunoreactivity in the amygdala in Alzheimer's disease.
The density of neurotensin immunoreactivity (NT-IR) was dramatically decreased in 6 of 12 amygdaloid nuclear subregions in patients with Alzheimer's disease (AD) compared to age-matched normals. Diminution of NT-IR was most pronounced in amygdaloid regions containing the greatest number of senile plaques. This contrasts to our previous findings of little, if any, loss of substance P or somatostatin immunoreactivity within these same regions. The present findings corroborate biochemical reports of a decrease in NT-IR in the AD amygdala and suggest that this peptide may be selectively affected relative to other neuropeptides.
Benzing
W C
WC
Department of Neurosciences, University of California, San Diego, La Jolla 92093.
Mufson
E J
EJ
Jennes
L
L
Armstrong
D M
DM
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000679:Amygdala / Q000276:immunology / Q000378:metabolism*; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009496:Neurotensin / Q000276:immunology / Q000378:metabolism*; D013004:Somatostatin / Q000276:immunology / Q000378:metabolism; D013373:Substance P / Q000276:immunology / Q000378:metabolism
D013373:Substance P; D009496:Neurotensin; D013004:Somatostatin