Compartments in rat dorsal and ventral striatum revealed following injection of 6-hydroxydopamine into the ventral mesencephalon.
The catecholamine selective neurotoxin, 6-hydroxydopamine, was injected into the ventral mesencephalon of rats and the distribution of tyrosine hydroxylase immunoreactivity in the striatum was compared to that of substance P and calbindin immunoreactivities, recognized histochemical markers of striatal compartments. Two components of the TH-IR mesostriatal innervation were identified. A more vulnerable component, present in the core of the nucleus accumbens and matrix of the caudate-putamen, excepting its ventrolateral part, was eliminated rapidly, unmasking a less vulnerable component which was present primarily in the shell of the nucleus accumbens and patch(striosome) compartment of the caudate-putamen. The TH-IR innervation in the ventrolateral caudate-putamen also was patchy following these lesions but the patches corresponded consistently to neither patch nor matrix compartments.
Zahm
D S
DS
Department of Anatomy and Neurobiology, St. Louis University School of Medicine, MO 63104.
D000818:Animals; D015415:Biomarkers; D064026:Calbindins; D002421:Caudate Nucleus / Q000033:anatomy & histology; D003342:Corpus Striatum / Q000033:anatomy & histology* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000502:physiology*; D009714:Nucleus Accumbens / Q000033:anatomy & histology; D016627:Oxidopamine / Q000494:pharmacology*; D011699:Putamen / Q000033:anatomy & histology; D051381:Rats; D011919:Rats, Inbred Strains; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D015415:Biomarkers; D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D013373:Substance P; D016627:Oxidopamine; D014446:Tyrosine 3-Monooxygenase