Xenogeneic neural transplantation: role of vasculature and MHC antigen in immunological rejection.
The reconstruction of blood vessels in a graft is one of the important events inducing immunological rejection. First, we investigated the reconstruction of blood vessels in a graft by using a monoclonal antibody against mouse endothelial surface antigen 1. Secondly, the lymphocyte proliferative response to Ia antigen were examined in mixed lymphocyte cultures by using monoclonal antibodies against Ia antigen. The results show that the blood vessels originating in the host tissue inoculate with those originating in the donor graft tissue and that the expression of Ia antigen on the vascular endothelial cells plays an important role in the immunological rejection through sensitization of peripheral lymphocytes.
Nakano
Y
Y
Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan.
Takei
K
K
Kohsaka
S
S
Takayama
H
H
Otani
M
M
Tsukada
Y
Y
Toya
S
S
D000818:Animals; D016380:Brain Tissue Transplantation / Q000276:immunology*; D002540:Cerebral Cortex / Q000098:blood supply / Q000276:immunology / Q000637:transplantation; D004730:Endothelium, Vascular / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007150:Immunohistochemistry; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008809:Mice, Inbred C3H; D009389:Neovascularization, Pathologic / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains
D000949:Histocompatibility Antigens Class II