Beta 1-integrin-mediated neuronal responses to extracellular matrix proteins.
Immunologic and biochemical studies demonstrate that beta 1-class integrin heterodimers mediate attachment and neurite outgrowth by primary neurons and neuronal cell lines in response to neurite-promoting ECM molecules. Individual cells are likely to express several alpha beta 1 integrins, each possessing unique ligand specificities. In some cases, a cell may express two beta 1 integrins that recognize different binding domains in a single ECM ligand, as appears to be the case for the alpha 3 beta 1 and alpha 1 beta 1 integrins on PC12 cells. Thus, the responses of a neuron to even a single ligand may be regulated by the combined action of several receptors. Finally, preliminary studies suggest that neurons can regulate the ligand specificity of individual integrin heterodimers (e.g., alpha 1 beta 1). Given the tremendous diversity in the extracellular matrix surrounding them, it is not surprising that neurons possess intrinsic factors that dictate if and how they respond to a particular ECM component.
Tomaselli
K J
KJ
Athena Neurosciences, Inc., South San Francisco, California 94080.
D000818:Animals; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D019012:Integrin beta1; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D007797:Laminin / Q000378:metabolism; D008024:Ligands; D009474:Neurons / Q000502:physiology*; D016716:PC12 Cells / Q000378:metabolism / Q000502:physiology
D016326:Extracellular Matrix Proteins; D019012:Integrin beta1; D016023:Integrins; D007797:Laminin; D008024:Ligands