[Pharmacokinetic parameters as criteria for clinical use of hydroxyethyl starch preparations].
Pharmacokinetic Parameters as Criteria for Clinical Use of Hydroxyethyl Starch Preparations In a study with volunteers (n = 2 x 6) pharmacokinetic data of two only marginally differing starch preparations were investigated. We were able to demonstrate that there exist significant differences in raw materials used which determined the pharmacokinetic data in humans. Newly implemented analyzing methods (LALLS) were used. In addition to the degree of substitution, further differences concerning the position of hydroxyethylization at the anhydroglucose molecule could be documented. The C2/C6 positions of hydroxyethylization at the molecule seem to be most essential. To classify and to differentiate starch preparations we propose to include these data in general informations for clinicians because these differences might determine clinical usage and efficacy.
Weidler
B
B
Abteilung für Anästhesiologie und operative Intensivmedizin, Justus-Liebig-Universität, Giessen.
von Bormann
B
B
Sommermeyer
K
K
Lohmann
E
E
Peil
J
J
Hempelmann
G
G
D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000493:pharmacokinetics*; D008297:Male; D008970:Molecular Weight; D014783:Viscosity
D006895:Hydroxyethyl Starch Derivatives
Pharmakokinetische Merkmale als Kriterien für den klinischen Einsatz von Hydroxyethylstärke.