Hereditary hemorrhagic telangiectasia: analysis of platelet aggregation and fibrinolytic system in seven patients.
Hereditary hemorrhagic telangiectasia (HHT) is an inherited disorder characterized by the presence of generalized mucocutaneous and visceral telangiectasias associated with recurrent bleeding. In order to analyze the mechanism of bleeding in HHT we studied the hemostatic system and platelet in vitro aggregation in 7 unrelated patients suffering from HHT. Unlike the authors of previous reports, we could not find any significant alteration of the parameters measured suggesting a possible local role of the affected endothelial cells.
Sureda
A
A
Hematology Department, Hospital Ramón y Cajal, Madrid, Spain.
César
J
J
García Frade
L J
LJ
García Avello
A
A
Fernández Fuertes
I
I
Navarro
J L
JL
D001798:Blood Proteins / Q000032:analysis; D005260:Female; D005341:Fibrinolysin / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects; D005353:Fibronectins / Q000097:blood; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010958:Plasminogen / Q000032:analysis; D010974:Platelet Aggregation / Q000187:drug effects; D017293:Protein S; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000097:blood*; D000979:alpha-2-Antiplasmin / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
D001798:Blood Proteins; D005353:Fibronectins; D006023:Glycoproteins; D017293:Protein S; D000979:alpha-2-Antiplasmin; D000511:alpha-Macroglobulins; C024668:plasmin-alpha(2)-macroglobulin complex; D010958:Plasminogen; D005341:Fibrinolysin