Increased in vitro sensitivity of Candida albicans to fluconazole.
Sodium dioctyl sulfosuccinate (SDSS), an anionic surfactant used at a non-antimicrobial concentration, increased the sensitivity of Candida albicans to fluconazole in complex media (such as Sabouraud). The conditions were assessed to determine the in vitro sensitivity to fluconazole. In this connection, the use of a liquid medium at a non-alkaline pH is important. The presence of SDSS in complex media does not seem to affect the neutralization of a particular substances but favours the activity of fluconazole.
Simonetti
N
N
Microbiology Institute, Faculty of Pharmacy, University of Rome, La Sapienza, Italy.
D'Auria
F D
FD
Strippoli
V
V
D002176:Candida albicans / Q000187:drug effects*; D003470:Culture Media; D004143:Dioctyl Sulfosuccinic Acid / Q000494:pharmacology*; D004357:Drug Synergism; D015725:Fluconazole / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests
D003470:Culture Media; D004143:Dioctyl Sulfosuccinic Acid; D015725:Fluconazole