Receptors, phosphoinositol hydrolysis and plasticity of nerve cells.
Excitatory amino acid neurotransmission has been shown to be necessary but may not be sufficient, for the production of LTP and other prolonged changes in synaptic transmission. Excitatory neurotransmission may produce depolarization-induced increases in intracellular calcium that cause PI hydrolysis and synergistically potentiate receptor-G protein induced PI hydrolysis. This synergistic potentiation of phosphoinositide hydrolysis, and increased [Ca]i due to positive cross stimulation, may lead to depolarization block, a persistent increase in protein kinase activation, altered morphology, oncogene activity and other plasticity changes important in memory.
Pontzer
N J
NJ
Department of Pharmacology and Therapeutics, College of Medicine, J.H.M. Health Center, Gainesville, FL 32610.
Chandler
L J
LJ
Stevens
B R
BR
Crews
F T
FT
D000818:Animals; D002118:Calcium / Q000502:physiology; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002217:Carbachol / Q000494:pharmacology; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000502:physiology; D015640:Ion Channel Gating / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects; D008563:Membrane Lipids / Q000502:physiology; D008564:Membrane Potentials; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010716:Phosphatidylinositols / Q000502:physiology*; D011494:Protein Kinases / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D015290:Second Messenger Systems; D010738:Type C Phospholipases / Q000502:physiology
D007473:Ion Channels; D008563:Membrane Lipids; D010716:Phosphatidylinositols; D017981:Receptors, Neurotransmitter; D002217:Carbachol; D011494:Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D010738:Type C Phospholipases; D002118:Calcium