Carcinogenic ranking of aromatic amines and nitro compounds.
A scheme is proposed for ranking the carcinogenicity of aromatic amines and nitro compounds based on both qualitative (weight of evidence) and quantitative (carcinogenic potency, i.e. the TD50 value) factors. The scheme has been drawn up specifically with a view to linking with workplace hygiene controls. Other essential features are that a reliable database exists for the TD50 values for many compounds and that the scheme is capable of usage by non-toxicologists. Validation of the scheme using 38 aromatic amines or nitro compounds indicates that the main objectives have been met. Extension to different chemical classes should be possible but has not been attempted in this work. An example of a potential hygiene control scheme for use alongside the carcinogenicity ranking is described.
Crabtree
H C
HC
ICI Colours and Fine Chemicals, Blackley, Manchester, Great Britain.
Hart
D
D
Thomas
M C
MC
Witham
B H
BH
McKenzie
I G
IG
Smith
C P
CP
D000588:Amines / Q000145:classification / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000145:classification / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009574:Nitro Compounds / Q000145:classification / Q000633:toxicity*; D013329:Structure-Activity Relationship
D000588:Amines; D002273:Carcinogens; D009574:Nitro Compounds