[Normal immune function in highly malignant non-Hodgkin's lymphomas].
We performed lymphocyte transformation tests using 14 different mitogens and antigens, determined T-cell- and T-cell subpopulation counts (CD3, CD4, CD8), the CD4/8 ratio, granulocyte chemotaxis and granulocyte adherence in 88 healthy controls, 8 patients with immunoblastoma (IB) and 6 patients with lymphoblastoma (LB). Using cluster and discrimination analyses (F-test; t-test) according to the programs of the UCLA (BMDP2N) the control group (n = 88) could be divided into 3 groups with significantly different lymphocyte responses to mitogenic and antigenic stimulation (21 high-, 18 medium, and 49 low responders). Comparing the lymphocyte reactivity of IB and LB patients to these immunofunctional different clusters we found a complete accordance of the lymphoma patients to the healthy low responder group.
Zeiler
T
T
Abteilung Innere Medizin, Universitätsklinikum Rudolf Virchow Standort Charlottenburg, Freie Universität Berlin.
Weisbach
V
V
Zingsem
J
J
Heuft
H G
HG
Mempel
W
W
Wilmanns
W
W
Eckstein
R
R
D000328:Adult; D000368:Aged; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D016176:T-Lymphocyte Subsets / Q000276:immunology*
Normale Immunfunktion bei hochmalignen Non-Hodgkin-Lymphomen.