title: [Kawasaki disease].
abstract: First described in Japan in 1967, Kawasaki disease is now observed in all countries. Despite extensive research, the aetiology of this infectious disease which affects mainly infants and young children remains mysterious. The six main clinical presentations of Kawasaki disease are: prolonged fever, conjunctivitis, lesions of the oral and pharyngeal mucosa, inflammatory reddening and swelling of the hands and feet, skin rash and cervical lymph node enlargement. Laboratory data show an inflammatory syndrome and thrombocytosis. The disease usually resolves within a few weeks. The major risk is cardiovascular involvement with pericarditis, myocarditis and, chiefly, coronary artery aneurysms which usually regress but are the main cause of mortality (1 to 2 p. 100 of the cases). Treatment consists of gammaglobulins and aspirin in high doses; when administered at an early stage, it prevents the formation of coronary aneurysms.
authors.affiliation: Unité de réanimation pédiatrique, hôpital Edouard-Herriot, Lyon, France.
authors.forename: D
authors.initials: D
authors.lastname: Floret
mesh_terms: D001241:Aspirin / Q000627:therapeutic use; D002648:Child; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D005719:gamma-Globulins; D001241:Aspirin
vernacular_title: La maladie de Kawasaki.