[Leukocyte migration inhibitory factor and basophil degranulation in drug reactions].
We performed a prospective study in patients with a medical history of adverse reaction to drugs with the purpose of rule out allergy. We included 31 patients who were attended in the Allergy Service. We compared the sensibility and specificity of the test of inhibition factor of leucocytes migration and degranulation basophil against the exposition. After the statistical analysis, we concluded: the laboratory test, we have already mentioned, have little sensibility and specificity so the exposition test in the quickest, useful, and more simple method to determine drugs allergy, but more dangerous.
Rangel
H
H
Departamento de alergia e inmunología, Hospital de Especialidades Centro Médico La Raza, Instituto Mexicano del Seguro Social.
Montero
P
P
Espinosa
F
F
Castillo
F J
FJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D015549:Basophil Degranulation Test; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000097:blood / Q000175:diagnosis*; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006636:Histamine Release; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D007961:Leukocyte Migration-Inhibitory Factors
Factor inhibidor de la migración de leucocitos y degranulación de basófilos en las reacciones a medicamentos.