SCE-measurements as tool for evaluation of drug-induced chromosomal disorders.
A staining procedure that detects sister chromatid exchanges has been used to examine the response of chromosomes in cultured human fibroblasts to a series of chemical and physical mutagens. The test represents a sensitive and reproducible method for detecting mutagenicity on the chromosome level. It provides a powerful method for the detection of environmental mutagens and can be used in ocular toxicity studies.
Baumstark-Khan
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Institute of Radiation Biology, Bonn, FRG.
Rink
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H
D001761:Bleomycin / Q000633:toxicity; D001973:Bromodeoxyuridine / Q000633:toxicity; D002453:Cell Cycle; D004252:DNA Mutational Analysis; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008938:Mitosis; D009152:Mutagenicity Tests; D015203:Reproducibility of Results; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000528:radiation effects; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays; D014965:X-Rays
D001761:Bleomycin; D005020:Ethyl Methanesulfonate; D001973:Bromodeoxyuridine