title: Endometrial carcinoma with trophoblastic differentiation. An aggressive form of uterine cancer.
abstract: Three cases of poorly differentiated endometrial adenocarcinoma showing trophoblast-like differentiation are reported. The multinucleated, syncytiotrophoblast-like cells were strongly positive for beta-human chorionic gonadotropin (beta-HCG) by immunohistochemical study. High levels of beta-HCG were also present in the patients' serum, but dropped significantly after treatment. The patients had an unusually rapid and progressive clinical course with widespread dissemination and death by tumor.
authors.affiliation: Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: C
authors.initials: C
authors.lastname: Pesce
authors.forename: M J
authors.initials: MJ
authors.lastname: Merino
authors.forename: J T
authors.initials: JT
authors.lastname: Chambers
authors.forename: F
authors.initials: F
authors.lastname: Nogales
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D006063:Chorionic Gonadotropin / Q000032:analysis; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010446:Peptide Fragments / Q000032:analysis; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments