[Levels of tumor necrosis factor and interleukin 1 in uremia and in hemodialysis].
The present study aimed to assess the serum levels of tumor necrosis factor (TNFalpha) and Interleukin-1 (IL-1) in uremic patients and those patients undergoing extracorporeal replacement therapy in relation to the duration of dialysis and the type of membrane. Serum cytokine values were assayed using an immunoradiometric technique (monoclonal antibodies) in 28 uremic patients and 7 healthy controls. TNFalpha levels were normal in control subjects but increased in uremic patients. Patients undergoing hemodialytic treatment showed increases which were statistically significant in comparison to basal levels, with a trend which was directly correlated to the duration of dialysis. No significant variations were induced by the different types of dialysis membranes used. In virtually all patients IL-1 values could not be assayed using this method.
Peona
C
C
Servizio di Nefrologia e Dialisi, Ospedale Sant'Andrea, Vercelli.
Fortina
A
A
Colombo
P
P
Filiberti
O
O
Cagna
G
G
Costantini
L
L
Porcu
M
M
D000180:Acrylic Resins; D000181:Acrylonitrile / Q000031:analogs & derivatives; D000328:Adult; D000368:Aged; D002482:Cellulose / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007372:Interferons / Q000097:blood; D007375:Interleukin-1 / Q000097:blood*; D007378:Interleukins / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis / Q000295:instrumentation; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014511:Uremia / Q000097:blood* / Q000628:therapy
D000180:Acrylic Resins; D007375:Interleukin-1; D007378:Interleukins; D008567:Membranes, Artificial; D014409:Tumor Necrosis Factor-alpha; C016892:AN-69; D002482:Cellulose; D007372:Interferons; C009865:cuprammonium cellulose; D000181:Acrylonitrile
Livelli di tumor necrosis factor ed interleuchina-1 nell'uremia ed in emodialisi.