Various signal molecules modulate voltage-activated ion currents on snail neurons.
The modulatory effects of interleukin-1 (IL-1), an immunotransmitter, and FMRFamide, a molluscan neuropeptide, were studied on identified neurons of Helix pomatia L. (Mollusca, Gastropoda) by using the method of two microelectrode voltage clamp. IL-1 and FMRFamide uniformly decreased the voltage-activated inward current (ICa), while the voltage-dependent outward potassium current (Inet K) increased. IL-1 and FMRFamide were shown to use the same cellular targets as used by the low molecular weight neurotransmitters.
Szücs
A
A
Balaton Limnological Research Institute, Hungarian Academy of Sciences, Tihany.
Stefano
G B
GB
Hughes
T K
TK
Rózsa
K S
KS
D000818:Animals; D019835:FMRFamide; D006372:Helix, Snails; D007375:Interleukin-1 / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects*; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects*; D009479:Neuropeptides / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
D007375:Interleukin-1; D007473:Ion Channels; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D019835:FMRFamide