Further characterizations of bleomycin-sensitive (blm) mutants of Saccharomyces cerevisiae with implications for a radiomimetic model.
Direct selection for 12 mutations (blm) conferring hypersensitivities to lethal effects of bleomycins in Saccharomyces cerevisiae resulted in mutants exhibiting cross-hypersensitivity to ionizing radiation and hydrogen peroxide. Remaining mutations did not confer cross-hypersensitivity to radiation. All blm mutations were recessive, except codominant blm3-1, and were assigned to seven complementation groups.
Moore
C W
CW
City University of New York, Department of Microbiology, Medical School, New York 10031.
D001761:Bleomycin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002874:Chromosome Mapping; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial / Q000235:genetics; D005816:Genetic Complementation Test; D006861:Hydrogen Peroxide / Q000494:pharmacology; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014466:Ultraviolet Rays / Q000009:adverse effects
D001761:Bleomycin; D004247:DNA; D006861:Hydrogen Peroxide