In vitro studies on genotoxicity and cytotoxicity of the anticancer drugs cisplatin and cofplaton, a caffeine-8-ether plus cisplatinum compound.
The cytotoxic and genotoxic properties of the newly designed anticancer drug 'cofplaton' were investigated. Since cofplaton is a cisplatin (CDDP) plus caffeine compound, the widely applied anticancer drug CDDP alone or in combination with caffeine was studied in parallel. As measured by the MTT test the cytotoxicity of the two drugs was comparable, but cofplaton exhibited significantly fewer genotoxic side effects than CDDP in the chromosome aberration test as well as in the SCE assay. First results from animal studies indicate that cofplaton exerts antitumor activity comparable to CDDP. Because of its relatively low genotoxicity, cofplaton seems to be a promising drug in human anticancer therapy.
Vogel
R
R
Max von Pettenkofer-Institut, Bundesgesundheitsamt, Berlin, Germany.
Laschinski
G
G
Spielman
H
H
Ehrlich
W
W
Drevenstedt
B
B
Klosa
J
J
Kröger
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001755:Blastocyst; D002110:Caffeine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology*; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010984:Platinum / Q000494:pharmacology; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects*
D000970:Antineoplastic Agents; D009153:Mutagens; D009944:Organoplatinum Compounds; D002110:Caffeine; D010984:Platinum; C033823:cofplaton; D002945:Cisplatin