title: Clinical and immunohistochemical studies of subependymal giant cell astrocytomas associated with tuberous sclerosis.
abstract: Two cases of TS associated with brain tumors had severe psychomotor retardation and early onset of long-term intractable convulsions, compared with cases without tumors. In one case, the tumor was partially cystic and progressed rapidly. Immunohistochemical studies of neuron specific enolase, glial fibrillary acidic protein and myelin basic protein revealed differences in positivity between cell types and between cases. These results suggested that the origin of the tumor cells could be variably differentiated cells.
authors.affiliation: Division of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: H
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Sugai
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Hirayama
authors.forename: N
authors.initials: N
authors.lastname: Sakuragawa
authors.forename: M
authors.initials: M
authors.lastname: Arima
authors.forename: S
authors.initials: S
authors.lastname: Takashima
authors.forename: N
authors.initials: N
authors.lastname: Aoki
mesh_terms: D000293:Adolescent; D000328:Adult; D001254:Astrocytoma / Q000150:complications / Q000473:pathology*; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D004676:Myelin Basic Protein / Q000276:immunology; D010751:Phosphopyruvate Hydratase / Q000276:immunology; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed; D014402:Tuberous Sclerosis / Q000150:complications / Q000473:pathology*
chemical_list: D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein; D010751:Phosphopyruvate Hydratase