[Importance of DNA-cytometric parameters in the prediction of blast crisis in the course of chronic myelogenous leukemia].
In a retrospective study the DNA-cytometric parameters stemline ploidy, stemline shoulder fraction and proliferative fraction were followed during the course of the disease in 20 patients with chronic myelogenous leukemia. Stemline ploidy and stemline shoulder fraction significantly increased whereas the proliferative fraction steadily decreased during the disease most of these changes taking place during chronic phase before the clinical onset of blast crisis. Prognostically relevant cutpoints indicating disease transformation during the next 12 months could be defined.
Kropff
M
M
Institut für Pathologie der RWTH, Aachen.
Wenzler
T
T
Wagner
A
A
Muller
C P
CP
Böcking
A
A
D001752:Blast Crisis / Q000175:diagnosis*; D004273:DNA, Neoplasm / Q000032:analysis*; D005434:Flow Cytometry / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies
D004273:DNA, Neoplasm
Bedeutung DNA-zytometrischer Parameter zur Vorhersage eines Blastenschubs im Verlauf der chronisch-myeloischen Leukämie.