title: Collagen vascular disease.
abstract: The iatrogenic L-tryptophan-induced eosinophilia-myalgia syndrome, often considered to be a "new" disease, has proven to be a remarkable mimic of the classic sclerosing rheumatologic disorders. Although subacute cutaneous lupus erythematosus remains a clinically defined entity, supportive histologic and immunopathologic findings have recently been proposed. Rheumatoid neutrophilic dermatitis needs to be added to our usual differential diagnosis of a neutrophilic dermatosis without leukocytoclastic vasculitis. The antiphospholipid syndrome is associated with noninflammatory vascular thrombosis and often has recognizable cutaneous findings. Finally, ANCA are a valuable adjunct in the systemic evaluation of patients with vasculitis syndromes and suggest a common pathogenesis for several of the systemic vasculitides.
authors.affiliation: University of Missouri-Columbia.
authors.forename: J D
authors.initials: JD
authors.lastname: DeSpain
authors.forename: R W
authors.initials: RW
authors.lastname: Swinfard
mesh_terms: D016736:Antiphospholipid Syndrome / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000150:complications; D001323:Autoantibodies / Q000032:analysis; D003095:Collagen Diseases / Q000473:pathology*; D003593:Cytoplasm / Q000276:immunology; D003872:Dermatitis / Q000150:complications / Q000473:pathology; D016603:Eosinophilia-Myalgia Syndrome / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000473:pathology; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000473:pathology; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology*; D014652:Vascular Diseases / Q000473:pathology*
chemical_list: D001323:Autoantibodies