[Treatment of ventricular arrhythmia resistant to sodium channel blockaders].
The efficacy of antiarrhythmic agents of various groups (Na(+)- and Ca(2+)-channel blockers, cordarone) was comparatively evaluated in the same patients with ventricular arrhythmias. Cordarone and Na(+)-channel blockers were equally effective, whereas verapamil was significantly less potent. Then the antiarrhythmic efficacy of verapamil and cordarone was assessed individually in rhythm disturbances responsive to Na(+)-channel blockers and resistent to their action. The efficacy of verapamil was significantly higher in patients resistant to Na+ blockers than in those responsive to them. The action of cordarone was equal in these two groups of patients, however, it occasionally abolished arrhythmias resistant to both Na(+)- and Ca(+)-current blockers. The findings suggest the pattern of choosing antiarrhythmic therapy in ventricular arrhythmias.
Shpektor
A V
AV
Susliak
N N
NN
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D004351:Drug Resistance; D006801:Humans; D008875:Middle Aged; D010640:Phenothiazines / Q000627:therapeutic use*; D015222:Sodium Channels / Q000187:drug effects; D013614:Tachycardia, Paroxysmal / Q000188:drug therapy*; D014700:Verapamil / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D015222:Sodium Channels; D014700:Verapamil; C046818:ethacizine; D000638:Amiodarone
Lechenie zheludochkovykh narusheniĭ ritma serdtsa, rezistentnykh k blokatoram natrievykh kanalov.