title: Pregnancy associated with lupus anticoagulant and heparin induced thrombocytopenia: management with a low molecular weight heparinoid.
abstract: The management of pregnant patients with coagulopathies and heparin induced thrombocytopenia is difficult and poorly defined. We report the case of a patient who was treated with a low molecular weight heparinoid. The treatment was complicated by the delayed occurrence of thrombocytopenia and a thrombotic event. This is the first report of thrombocytopenia caused by heparinoid. It is possible that this complication could have been avoided by a shorter duration of treatment with heparinoid and the use of Vitamin K antagonists during the second trimester of pregnancy.
authors.affiliation: Division of Hematology/Oncology, Indiana University Hospitals, Indianapolis 46202-5121.
authors.forename: K
authors.initials: K
authors.lastname: van Besien
authors.forename: R
authors.initials: R
authors.lastname: Hoffman
authors.forename: A
authors.initials: A
authors.lastname: Golichowski
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D001779:Blood Coagulation Factors / Q000032:analysis / Q000276:immunology; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D005260:Female; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006493:Heparin / Q000009:adverse effects*; D006496:Heparinoids / Q000627:therapeutic use*; D006497:Heparan Sulfate; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*
chemical_list: D001779:Blood Coagulation Factors; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006025:Glycosaminoglycans; D006493:Heparin; D006496:Heparinoids; D006497:Heparan Sulfate; D016682:Lupus Coagulation Inhibitor; C035838:danaparoid