Osteoclast-like giant cell tumour of the urinary bladder.
We report two cases of osteoclast-like giant cell tumour of urinary bladder associated with papillary transitional cell tumours. Both cases were morphologically identical to giant cell tumour of bone. The giant cells stained strongly for acid phosphatase which was resistant to tartrate digestion, a staining reaction typical of osteoclasts. In view of the ability of urinary bladder to induce metaplastic and neoplastic bone, we believe that these tumours may represent extraosseous giant cell tumours of bone.
Amir
G
G
Department of Pathology, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel.
Rosenmann
E
E
D000135:Acid Phosphatase / Q000378:metabolism; D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005870:Giant Cell Tumors / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D018396:Mucin-1; D009113:Muramidase / Q000378:metabolism; D010010:Osteoclasts / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D014746:Vimentin / Q000378:metabolism
D008562:Membrane Glycoproteins; D018396:Mucin-1; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins; D000135:Acid Phosphatase; D009113:Muramidase