[An experimental study of the safety of a chemical monovalent tableted cholera vaccine in enteral administration].
The safety of experimental chemical cholera monovalent vaccine in tablets, produced by the institute "Microbe" (Saratov, USSR), has been studied. The study has shown that the vaccine, administered to adult rabbits and germ-free suckling rabbits by the enteral route, retains residual toxicity, mainly due to the presence of O-antigen. One or two administrations of 1-2 human doses of this preparation to adult rabbits induce minimal structural changes admissible from the viewpoint of safety. After immunization made in two administrations immunobiological transformation develops more rapidly and is more pronounced than after immunization in a single administration.
Nazarova
L S
LS
Isupov
I V
IV
Dzhaparidze
M N
MN
Pavlova
L P
LP
Gor'kova
A V
AV
Dmitrieva
V P
VP
Chelova
L A
LA
D000284:Administration, Oral; D000818:Animals; D000833:Animals, Suckling; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000633:toxicity; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000633:toxicity*; D004306:Dose-Response Relationship, Immunologic; D005856:Germ-Free Life; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D019081:O Antigens; D011817:Rabbits; D013607:Tablets; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000633:toxicity; D014734:Vibrio cholerae / Q000276:immunology
D000942:Antigens, Bacterial; D022121:Cholera Vaccines; D019081:O Antigens; D013607:Tablets; D014614:Vaccines, Synthetic
Eksperimental'noe izuchenie bezvrednosti kholernoĭ khimicheskoĭ monovalentnoĭ tabletirovannoĭ vaktsiny pri énteral'nom vvedenii.