Effect of ketotifen on the methyltransferase activity of asthmatic patients.
The results of this study have revealed that asthmatic individuals have less methyltransferase activity, compared to healthy individuals. This is reflected in a less fluidity of the plasmatic membrane and thus, presents with less beta-receptors compared to healthy subjects. Ketotifen is capable of partially reversing this situation where it stimulates methyltransferase activity of asthmatic individuals approaching the enzyme activity to healthy individuals.
Castillo
J G
JG
Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Pamplona, Spain.
Gamboa
P M
PM
Santos
F
F
Oehling
A
A
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000485:Allergens / Q000276:immunology; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000201:enzymology* / Q000473:pathology; D004789:Enzyme Activation / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007665:Ketotifen / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects; D008780:Methyltransferases / Q000097:blood*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D015290:Second Messenger Systems / Q000187:drug effects; D015854:Up-Regulation
D000485:Allergens; D039741:Antigens, Dermatophagoides; D011943:Receptors, Adrenergic, beta; D008780:Methyltransferases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D007665:Ketotifen