Demonstration that ethanol potentiates the GABAA-activated Cl- current in central mammalian neurons.
Previous studies have suggested that ethanol potentiates GABA-mediated responses in the mammalian brain. In the present study, using patch-clamp techniques, we show that the GABAA-activated Cl- current was potentiated by ethanol in a subpopulation of mouse hippocampal cells.
Aguayo
L G
LG
Section of Electrophysiology, NIAAA, Rockville, MD 20852.
D000818:Animals; D002478:Cells, Cultured; D018118:Chloride Channels; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D005333:Fetus; D006624:Hippocampus / Q000502:physiology*; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018118:Chloride Channels; D007473:Ion Channels; D008565:Membrane Proteins; D011963:Receptors, GABA-A; D000431:Ethanol; D005680:gamma-Aminobutyric Acid