Oleic acid reversibly opens the blood-brain barrier.
This study examined the effect of intracarotid oleic acid infusion on blood-brain barrier permeability. Oleic acid was infused for 30 s at a rate of 6 ml/min into the right internal carotid artery at concentrations of 10(-6), 10(-5), 2 x 10(-5) and 5 10(-5) M. Extensive Evans blue-albumin extravasation was observed 15 min after the administration of 2 x 10(-5) M oleic acid. The permeability surface area product for alpha-aminoisobutyric acid (AIB), determined 1-11 min following the infusion of oleic acid was increased 10-fold following infusion of 10(-5) M oleic acid and 20-fold following the administration of 5 x 10(-5) M oleate. The blood-brain barrier opening to AIB proved to be reversible 80-90 min after the infusion of 2 x 10(-5) M oleic acid. The possible mechanisms of the oleic acid effect are discussed.
Sztriha
L
L
Department of Surgery, University of Michigan, Ann Arbor 48109.
Betz
A L
AL
D000621:Aminoisobutyric Acids / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000502:physiology; D002339:Carotid Arteries / Q000502:physiology; D003911:Dextrans / Q000378:metabolism; D007261:Infusions, Intra-Arterial; D007700:Kinetics; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D000621:Aminoisobutyric Acids; D003911:Dextrans; D009829:Oleic Acids; C100049:2-aminoisobutyric acid; D019301:Oleic Acid