Homology of placental protein 11 and pea seed albumin 2 with vitronectin.
Vitronectin (complement S-protein), a plasma and tissue glycoprotein of 75 kDa, shares the amino-terminal somatomedin B domain with the membrane glycoprotein PC1 of plasma cells and several hemopexin-type repeats with hemopexin and the non-catalytic carboxy-terminal domain of collagenases. It serves as a ligand for certain integrin receptors, binds to distinct members of the serpin family and inhibits the pore-forming cytolytic reaction of the terminal complement pathway. Computer-assisted data base searches revealed the presence of a single somatomedin B domain in the recently cloned placental protein 11, and four hemopexin-type repeats in the cytosolic plant protein PA2, the major albumin of pea seeds, whose function is unknown. Our finding shows that hemopexin-type repeats are present in extracellular as well as in cytosolic proteins and most likely originated before the divergence of the animal and plant kindoms.
Jenne
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Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.
D055516:2S Albumins, Plant; D000418:Albumins / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D016208:Databases, Factual; D007887:Fabaceae / Q000235:genetics*; D005260:Female; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010946:Plants, Medicinal; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013002:Somatomedins / Q000235:genetics; D019096:Vitronectin
D055516:2S Albumins, Plant; D000418:Albumins; D006023:Glycoproteins; D011257:Pregnancy Proteins; D013002:Somatomedins; D019096:Vitronectin; C069023:pea seed albumin 2; C036270:placental protein 11; C016756:somatomedin B