title: Protein loss from axonal transport occurs without diminution of vesicle traffic.
abstract: Protein loss from the rapid anterograde axonal transport system of amphibian sensory nerve fibers was compared with the numbers and sizes of anterogradely transported vesicles in the axons. Protein was found to be lost at a rate of approximately 2% per millimeter of nerve traversed. However, no changes were observed in either the numbers or sizes of vesicles in the nerve at two locations separated by 60-75 mm. The results show that protein loss is not explained as a loss of vesicles from the transport system nor by a reduction in vesicle size.
authors.affiliation: Dept of Applied Sciences in Medicine, University of Alberta, Edmonton, Canada.
authors.forename: R E
authors.initials: RE
authors.lastname: Snyder
authors.forename: C
authors.initials: C
authors.lastname: Xin
authors.forename: R S
authors.initials: RS
authors.lastname: Smith
mesh_terms: D000818:Animals; D001370:Axonal Transport; D066298:In Vitro Techniques; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009475:Neurons, Afferent / Q000378:metabolism; D012584:Sciatic Nerve / Q000378:metabolism; D014982:Xenopus laevis
chemical_list: D009419:Nerve Tissue Proteins