Neovascularisation of the meniscus with angiogenin. An experimental study in rabbits.
Angiogenin, a potent blood vessel inducing protein, was implanted into experimentally injured menisci of 75 New Zealand white rabbits. Localised neovascularisation occurred in 52% of the angiogenin-treated animals, and in 9% of the controls. Neovascularisation induced by angiogenin may enhance healing of injuries within the poorly vascularised meniscal fibrocartilage, and improve the results of meniscal repair.
King
T V
TV
Harvard Medical School, Boston, Massachusetts 02115.
Vallee
B L
BL
D000818:Animals; D004195:Disease Models, Animal; D008592:Menisci, Tibial / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000473:pathology; D011506:Proteins / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D011859:Radiography; D012259:Ribonuclease, Pancreatic; D014945:Wound Healing / Q000187:drug effects
D011506:Proteins; C046366:angiogenin; D012259:Ribonuclease, Pancreatic