[Effects of different administration of Salvia miltiorrhiza and heparin on antithrombin IIIAg, antithrombin III: A and alpha 2-macroglobulin in patients with cor pulmonale].
The effects of different administration of Salvia miltiorrhiza (SM) and heparin on ATIII and alpha 2-M in 102 patients with cor pulmonale were studied. The results showed that (1) the level of ATIII in patients was significantly lower than that in the controls (P less than 0.01). Heparin intravenous drip induced ATIII decreased; (2) the level of ATIII:A in patients with heparin vapour inhalation treatment was significantly higher than that with regular treatment and with heparin intravenous drip (P less than 0.05) and (P less than 0.005); (3) SM presents ATIII-like activity, after treatment with SM, the level of ATIII:A was significantly higher than that with heparin vapour inhalation, heparin intravenous drip and regular treatment (P less than 0.05-0.005), heparin may enhance the ATIII-like activity of SM; (4) the treatment combining SM intravenous drip with heparin vapour inhalation is an efficient therapy of anticoagulation on the patients with cor pulmonale. The level of alpha 2-M in each group did not reveal significant change.
Zhang
F C
FC
Third Teaching Hospital, Bethune University of Medical Sciences, Changchun.
Zheng
L J
LJ
D000328:Adult; D000336:Aerosols; D000368:Aged; D000941:Antigens; D000990:Antithrombin III / Q000276:immunology / Q000378:metabolism*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010618:Phenanthrolines / Q000008:administration & dosage*; D010936:Plant Extracts; D011660:Pulmonary Heart Disease / Q000097:blood / Q000188:drug therapy*; D027561:Salvia miltiorrhiza; D000511:alpha-Macroglobulins / Q000378:metabolism*
D000336:Aerosols; D000941:Antigens; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005343:Fibrinolytic Agents; D010618:Phenanthrolines; D010936:Plant Extracts; D000511:alpha-Macroglobulins; C028972:dan-shen root extract; D000990:Antithrombin III; D006493:Heparin