Acidic fibroblast growth factor (aFGF)-like immunoreactivity in the optic nerve.
Acidic fibroblast growth factor (aFGF)-like immunoreactivity was examined in the optic nerves of 1- to 25-month-old Wistar rats, 0.5- to 7-year-old bovine animals and normal human adults (24 and 35 years old), using cryostat sections incubated with a rabbit polyclonal antibody specific for aFGF. The immunoreactivity was associated with glial cells, and was localized predominantly in the nucleus. The presence of endogenous aFGF in the optic nerve of adult subjects and 'old' rats suggests that aFGF could play a role in the survival of retinal ganglion cells and their axons during aging.
Faucheux
B
B
Unité de Recherches Gérontologiques de l'INSERM (U118), Affiliée au CNRS, Paris, France.
Dupuis
C
C
Cohen
S Y
SY
Tourbah
A
A
Jonet
L
L
Raulais
D
D
Vigny
M
M
Courtois
Y
Y
Jeanny
J C
JC
D000328:Adult; D000375:Aging / Q000378:metabolism; D000818:Animals; D002196:Capillaries / Q000737:chemistry; D002417:Cattle / Q000378:metabolism; D002467:Cell Nucleus / Q000737:chemistry; D016220:Fibroblast Growth Factor 1 / Q000032:analysis*; D006801:Humans; D009457:Neuroglia / Q000737:chemistry; D009900:Optic Nerve / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism
D016220:Fibroblast Growth Factor 1