title: Effect of chloroquine on isolated mast cells.
abstract: Chloroquine liberated a relatively low amount of histamine from isolated rat mast cells. In a dose-dependent way, this drug inhibited histamine liberation from mast cells stimulated with compound 48/80, A23187, concanavalin A plus phosphatidylserine (Con A + PS) and abolished histamine liberation induced by exaprolol. The degranulation was decreased in cells stimulated with 48/80, Con A + PS and exaprolol. Chloroquine significantly inhibited the formation of thromboxane B2 in mast cells stimulated with 48/80, Con A + PS and A23187. We assume that chloroquine interferes with mast cells at a plasmic membrane site as well as intracellularly.
authors.affiliation: Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
authors.forename: R
authors.initials: R
authors.lastname: Nosál
authors.forename: K
authors.initials: K
authors.lastname: Drábiková
authors.forename: J
authors.initials: J
authors.lastname: Pecivová
mesh_terms: D000319:Adrenergic beta-Antagonists; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002738:Chloroquine / Q000008:administration & dosage / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D010718:Phosphatidylserines / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D010718:Phosphatidylserines; D011412:Propanolamines; D003208:Concanavalin A; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; D013929:Thromboxane B2; D002738:Chloroquine; C012969:exaprolol