[Determination of pancreatic blood flow at the early stage of acute haemorrhagic necrotizing pancreatitis induced by sodium taurocholate in rats].
Acute haemorrhagic necrotizing pancreatitis was induced by injecting 5% sodium taurocholate (Na-Tc) directly into the common biliopancreatic duct in rats. In control group 0.9% NaCl was used. The activity of serum lipase and amylase distinctly increased at 3 h and went up to the maximum at 12 h after injection of Na-Tc. The pancreatic blood flow and tissue perfusion per gram increased apparently at 1 h and decreased at 12 h after injection of Na-Tc by using the fractional indicator distribution technique with 86RbCl. The results demonstrated that the early stage of acute haemorrhagic necrotizing pancreatitis induced by Na-Tc in rats was still a primary inflammatory response.
Wu
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Department of Pathophysiology.
Xiong
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Q
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D008049:Lipase / Q000097:blood; D009336:Necrosis; D010179:Pancreas / Q000098:blood supply* / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000201:enzymology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D013656:Taurocholic Acid
D013656:Taurocholic Acid; D008049:Lipase; D000681:Amylases