title: Neuropeptides in temporomandibular joints with rheumatoid arthritis: a clinical study.
abstract: There is evidence that neuropeptides play a role in the development of arthritis. Synovial fluid from arthritic temporomandibular joints in patients with rheumatoid arthritis was therefore investigated for presence of the neuropeptides calcitonin gene-related peptide, substance P, neurokinin A and neuropeptide Y. All four peptides were found in the synovial fluid above plasma level, but calcitonin gene-related peptide showed the highest concentration and substance P the lowest.
authors.affiliation: Department of Clinical Oral Physiology, Karolinska Institutet, Huddinge, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Appelgren
authors.forename: B
authors.initials: B
authors.lastname: Appelgren
authors.forename: S
authors.initials: S
authors.lastname: Eriksson
authors.forename: S
authors.initials: S
authors.lastname: Kopp
authors.forename: T
authors.initials: T
authors.lastname: Lundeberg
authors.forename: M
authors.initials: M
authors.lastname: Nylander
authors.forename: E
authors.initials: E
authors.lastname: Theodorsson
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D015288:Neurokinin A / Q000032:analysis / Q000097:blood; D009478:Neuropeptide Y / Q000032:analysis / Q000097:blood; D009479:Neuropeptides / Q000032:analysis*; D013373:Substance P / Q000032:analysis / Q000097:blood; D013582:Synovial Fluid / Q000737:chemistry*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D009479:Neuropeptides; D013373:Substance P; D015288:Neurokinin A; D015740:Calcitonin Gene-Related Peptide