title: [Regulation of hormone biosynthesis in guinea pig adrenal glands by potassium ions as affected by dihydropyridines. 1. Analysis of changes in steroidogenesis evoked by dihydropyridines].
abstract: Influence of Ca2+ channel modulators BAY K 8644, nitrendipine and newly synthesized derivative of 1,4-dihydropyridine: 4-(3', 4'-dimethoxyphenyl)-2,6-dimethyl-3,5- diethoxy-carbonyl-1,4-dihydropyridine-(DHP-51) on aldosterone production by adrenocortical slices depends on K+ content in the incubation medium. The modulators only slightly influence the hormone output at low K+ level in the medium. Intensive synthesis of aldosterone at high level of potassium in the medium was prevented in the presence of DHP-51 and low concentration of BAY K 8644. DHP-51 inhibited [3H]-cholesterol incorporation into all main corticosteroids in the high-potassium medium.
authors.forename: N D
authors.initials: ND
authors.lastname: Tron'ko
authors.forename: V M
authors.initials: VM
authors.lastname: Pushkarev
authors.forename: I S
authors.initials: IS
authors.lastname: Chelnakova
authors.forename: L V
authors.initials: LV
authors.lastname: Iarovaia
authors.forename: A S
authors.initials: AS
authors.lastname: Mikosha
mesh_terms: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects*; D004095:Dihydropyridines / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D009568:Nitrendipine / Q000494:pharmacology; D011188:Potassium / Q000502:physiology*
chemical_list: D000305:Adrenal Cortex Hormones; D015220:Calcium Channels; D004095:Dihydropyridines; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D009568:Nitrendipine; D011188:Potassium
vernacular_title: Reguliatsiia biosinteza formonov v nadpochechnykh zhelezakh morskikh svinok ionami kaliia pri deĭstvii digidropiridinov. Analiz izmeneniĭ steroidogeneza, vyzyvaemykh digidropiridinami.