title: IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite.
abstract: The capacity of IL-6 to mediate the antiparasitic activity of IL-1 on intrahepatic development of malaria parasite was demonstrated. The comparisons of IL-6 levels in infected and noninfected hepatocyte cultures, either purified or enriched with nonparenchymal cells and stimulated by IL-1 or IL-6, indicate that subtle interactions exist between intrahepatocytic development of Plasmodium yoelii and liver synthesis of IL-6. During its intrahepatic multiplication, the parasite causes a decline in IL-6 production. IL-6 mRNA was not detected in the livers of infected mice during development of either hepatic or blood stage parasites although IL-6 activity was found in the sera during both stages.
authors.affiliation: INSERM U 313 Groupe Pitié-Salpétrière, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Pied
authors.forename: A
authors.initials: A
authors.lastname: Civas
authors.forename: F
authors.initials: F
authors.lastname: Berlot-Picard
authors.forename: L
authors.initials: L
authors.lastname: Renia
authors.forename: F
authors.initials: F
authors.lastname: Miltgen
authors.forename: M
authors.initials: M
authors.lastname: Gentilini
authors.forename: J
authors.initials: J
authors.lastname: Doly
authors.forename: D
authors.initials: D
authors.lastname: Mazier
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D002478:Cells, Cultured; D004912:Erythrocytes / Q000469:parasitology; D015870:Gene Expression; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000502:physiology*; D008099:Liver / Q000469:parasitology; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008809:Mice, Inbred C3H; D010967:Plasmodium yoelii / Q000254:growth & development / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D012333:RNA, Messenger