title: T-cell recognition of myelin basic protein.
abstract: Multiple sclerosis is a chronic inflammatory disease of the central nervous system which has been hypothesized to be autoimmune in nature. To test whether this is the case, Kai Wucherpfennig and colleagues have developed a set of criteria that must be met to satisfy the hypothesis. Here, they present these criteria and assess the extent to which studies to date satisfy them.
authors.affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA.
authors.forename: K W
authors.initials: KW
authors.lastname: Wucherpfennig
authors.forename: H L
authors.initials: HL
authors.lastname: Weiner
authors.forename: D A
authors.initials: DA
authors.lastname: Hafler
mesh_terms: D001324:Autoantigens; D001327:Autoimmune Diseases / Q000209:etiology / Q000628:therapy; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D009103:Multiple Sclerosis / Q000209:etiology / Q000628:therapy; D004676:Myelin Basic Protein / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D001324:Autoantigens; D004676:Myelin Basic Protein; D011948:Receptors, Antigen, T-Cell