Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients.
The authors measured intracellular Ca2+ concentrations in four manic and five bipolar depressed patients and seven comparison subjects. Platelet and lymphocyte intracellular Ca2+ concentrations were comparable. The patients' mean intracellular Ca2+ concentrations were higher than those of the comparison subjects and demonstrated more interindividual variation. These findings suggest a diffuse abnormality in mechanisms affecting intracellular calcium homeostasis in bipolar disorder.
Dubovsky
S L
SL
Department of Psychiatry, University of Colorado, School of Medicine, Denver.
Murphy
J
J
Thomas
M
M
Rademacher
J
J
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D001792:Blood Platelets / Q000737:chemistry*; D002118:Calcium / Q000097:blood* / Q000502:physiology; D005260:Female; D006801:Humans; D007424:Intracellular Fluid / Q000737:chemistry; D008214:Lymphocytes / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D015290:Second Messenger Systems / Q000502:physiology
D002118:Calcium