[The reticuloendothelial system in immunodeficiency].
The concept of the mononuclear phagocyte system (MPS) as advanced by van Furth et al. does not embrace other cell types which by virtue of their accessory cell function are inextricably linked to the immune response. Therefore, a modified functional definition of reticuloendothelial system (RES) encompassing the non-lymphatic effector and accessory cells of the immune response, i.e. monocytes/-macrophages, follicular and interdigitating reticulum cells as well as endothelial cells is proposed. In addition to their morphologic and functional characteristics, their behaviour in the setting of human immunodeficiency virus (HIV) infection is discussed. As examples serve the role of RES cells as target cells and reservoirs for HIV and their dysfunctions with regard to different HIV-associated conditions, e.g. tuberculosis and Kaposi's sarcoma.
Stutte
H J
HJ
Senckenbergisches Zentrum der Pathologie, Universitätsklinikums Frankfurt am Main.
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000503:physiopathology*; D000818:Animals; D015658:HIV Infections / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000503:physiopathology*; D012157:Mononuclear Phagocyte System / Q000276:immunology / Q000503:physiopathology*
Das retikuloendotheliale System (RES) bei Immunodefekten.