title: Clinical report and investigation of a patient with localized heat urticaria.
abstract: Localized heat urticaria is a rare disorder, in which the nature of the mediator is not fully established. We report the case of a 41-year-old woman with the condition, dependent upon mast cell integrity, in which histamine was demonstrated as the dominant, if not sole mediator. Non-sedative antihistamines conferred some therapeutic benefit, but subsequent sequential desensitization has enabled her to lead a full and active life again.
authors.affiliation: Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Higgins
authors.forename: P S
authors.initials: PS
authors.lastname: Friedmann
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003888:Desensitization, Immunologic / Q000379:methods; D005260:Female; D006634:Histamine H1 Antagonists / Q000008:administration & dosage; D006636:Histamine Release / Q000187:drug effects / Q000276:immunology; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D007271:Injections, Intradermal; D014581:Urticaria / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D003189:p-Methoxy-N-methylphenethylamine / Q000008:administration & dosage
chemical_list: D006634:Histamine H1 Antagonists; D003189:p-Methoxy-N-methylphenethylamine