Severe sun sensitivity and the presence of antinuclear antibodies in patients with polymorphous light eruption-like lesions. A form fruste of photosensitive lupus erythematosus?
BACKGROUND
Initial lesions seen in some cases of lupus erythematosus may simulate the clinical features of polymorphous light eruption.


OBJECTIVE
To evaluate the significance of antinuclear antibody screening in patients with polymorphous light eruption or to find better methods to define patients at risk to have lupus erythematosus, we analyzed the data of 198 patients with polymorphous light eruption.


METHODS
History, type, and persistence of skin lesions were reviewed, and serologic variables, the minimal erythema dose, and the ultraviolet action spectrum for inducing skin lesions were determined.


RESULTS
The morphologic features of skin lesions and results of phototesting were consistent with previously published characteristics of patients with polymorphous light eruption. Twenty-eight (14%) had high titers of antinuclear antibody (greater than or equal to 1:80). We found a highly significant correlation between severe sun sensitivity and the presence of high antinuclear antibody titers. Of these patients with severe sun sensitivity and high titers of antinuclear antibody, in three the diagnosis of systemic lupus erythematosus could be established according to American Rheumatism Association criteria.


CONCLUSIONS
These results suggest that a combination of severe sun sensitivity and high titers of antinuclear antibody may characterize a subset of sun-sensitive patients with some features of lupus erythematosus.
Petzelbauer
P
P
Department of Dermatology I, University of Vienna Medical School, Austria.
Binder
M
M
Nikolakis
P
P
Ortel
B
B
Hönigsmann
H
H
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D008297:Male; D010787:Photosensitivity Disorders / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D012307:Risk Factors; D012867:Skin / Q000473:pathology; D013472:Sunlight / Q000009:adverse effects*
D000974:Antibodies, Antinuclear