The use of three different therapeutic protocols according to the immunologic pathology present in three women with recurrent spontaneous abortion and fetal death for immunologic reasons: flucortolone and salicylates; high-dose intravenous gammaglobulins; subcutaneous heparin.
The authors report three cases of immunologic spontaneous abortions and fetal death. In the first patient there was lupus-like anticoagulant activity with a diagnosis of sub-clinical autoimmune disease; the second showed inadequate blocking factor activity, while the third subject presented excessive lymphocytotoxicity. In these cases three different therapeutic protocols were successfully used: flucortolone and salicylates, high-dose intravenous gammaglobulins and subcutaneous heparin.
Cimino
C
C
Istituto Materno-Infantile, Università di Palermo.
Perino
A
A
Barba
G
G
Cittadini
E
E
Marcenò
R
R
Cavallaro
A M
AM
Indovina
A
A
D000026:Abortion, Habitual / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications; D003602:Cytotoxicity, Immunologic; D005260:Female; D005313:Fetal Death / Q000209:etiology / Q000276:immunology / Q000517:prevention & control; D005448:Fluocortolone / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy; D007959:Lymphocyte Culture Test, Mixed; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011247:Pregnancy; D012459:Salicylates / Q000627:therapeutic use*; D020156:Salicylic Acid; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology; D005719:gamma-Globulins / Q000627:therapeutic use*
D012459:Salicylates; D005719:gamma-Globulins; D005448:Fluocortolone; D006493:Heparin; D020156:Salicylic Acid