title: Titer and specificity of autoantibody to beta 2-microglobulin in sera from patients with rheumatic disease.
abstract: Sera from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and mixed connective tissue disease (MCTD) possessed higher titer of antibody to human beta 2-microglobulin (beta 2m) than those from healthy controls and patients with Behçet's disease in the enzyme-linked immunosorbent assay. It was also confirmed by the immunoprecipitation method. Anti-beta 2m antibody in sera from those patients immunoprecipitated free beta 2m but not beta 2m in association with major histocompatibility complex class I antigen heavy chain. It was suggested that anti-beta 2m antibody in sera from either patients or healthy controls might be directed mainly against free beta 2m. The relationship between the anti-beta 2m antibody and anti-lymphocytotoxic antibody found in those patients is discussed.
authors.affiliation: Department of Microbiology, Aichi Medical University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Yokochi
authors.forename: A
authors.initials: A
authors.lastname: Yanagawa
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushima
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000276:immunology*; D008297:Male; D012216:Rheumatic Diseases / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D007143:Immunoglobulin Heavy Chains; D001613:beta 2-Microglobulin