[The CNS in AIDS and in asymptomatic HIV positive patients].
Neuropathological investigations were carried out on 166 autopsies of HIV-seropositive patients, with and without AIDS. Opportunistic infections and lymphomas were present in about 50% of cases; 65 patients were bearers of HIV-encephalopathy. HIV core protein p24 was detected in few mono- and multinucleated macrophages (HIV-cells), only in cases with HIV-encephalopathy. In the CNS of HIV-positive, asymptomatic patients no histological or immunohistochemical abnormalities were seen. These findings let suppose that AIDS-Dementia is a result of a late infiltration of HIV-infected macrophages from the bloodstream into the brain and not due to an impairment of neuronal or glial cells infected by HIV in the early stages of the disease.
Gullotta
F
F
Institut für Neuropathologie, Universität Münster.
Kuchelmeister
K
K
Bergmann
M
M
Schindelmeiser
J
J
Masini
T
T
Cappricci
E
E
Angeli
G
G
Ramponi
A
A
D015526:AIDS Dementia Complex / Q000473:pathology*; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology*; D001344:Autopsy; D002490:Central Nervous System / Q000473:pathology*; D006679:HIV Seropositivity / Q000473:pathology*; D006801:Humans; D009894:Opportunistic Infections / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000473:pathology
Das ZNS bei AIDS und bei asymptomatischen HIV-Trägern.