Regional effects on the cerebral concentration of noradrenaline, serotonin and dopamine in suckling rats after a single dose of lindane.
The effect of a low single dose of lindane (gamma-hexachlorocyclohexane) on monoaminergic neurotransmission during brain postnatal development was studied in 8-, 15-, 22- and 29-day-old suckling rats. Concentrations of noradrenaline, serotonin, dopamine and their metabolites were determined in eight cerebral regions 1 h after dosing (20 mg/kg lindane per os). All these aminergic systems were altered in a regional- and age-related pattern. Decreases of noradrenaline in regions rich with noradrenergic terminals together with increases of the ratio 5-HIAA/serotonin and DOPAC/dopamine suggest, as a whole, an enhanced release of the monoamines. This increased neuronal activity does not exclude an initial action of lindane on the inhibitory GABAergic system that would activate the neurotransmitter release in other systems shortly after a single administration of the neurotoxic agent.
Rivera
S
S
Department of Pharmacology and Toxicology, Consejo Superior de Investigaciones Científicas (CSIC), Barcelona, Spain.
Sanfeliu
C
C
Suñol
C
C
Rodríguez-Farré
E
E
D000375:Aging / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D012727:Sex Characteristics
D001679:Biogenic Amines; D012701:Serotonin; D001556:Hexachlorocyclohexane; D004298:Dopamine; D009638:Norepinephrine