Long-term dietary study and development of no-observed-effect level (NOEL) of technical HCH to rats.
Daily feeding of technical hexachlorocyclohexane (HCH) (0.5, 5, 25, 250, and 500 mg/kg diet/d) for a period of 360 d to male rats elicited a dose-dependent toxicity, while the dose of technical HCH (0.5 mg/kg diet/d) did not produce signs of intoxication, mortality, organ body weight ratio, enzymatic, and pathomorphological changes. Other doses (5, 25, 250, and 500 mg/kg diet/d) produced significant changes in one or the other parameters studied. Based on this study, it may be suggested that the lowest dose of technical HCH (0.5 mg/kg diet/d) could be considered as the no-observed-effect level in experimental rats.
Dikshith
T S
TS
Pesticide Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Raizada
R B
RB
Srivastava
M K
MK
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D002531:Cerebellum / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004798:Enzymes / Q000097:blood; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009929:Organ Size; D051381:Rats; D013737:Testis / Q000187:drug effects
D004798:Enzymes; D001556:Hexachlorocyclohexane