[Experimental study of schistosome immune RNA on transfer of cellular and humoral immunity to normal mice].
The present paper reported the extraction of immune RNA (iRNA) from spleen cells of Schistosoma japonicum infected rabbits and the activity of this schistosome iRNA (SiRNA) on transfer of cellular immunity and humoral immunity using macrophage migratory inhibition test (MMIT) and Dot-ELISA. The results indicated that specific cellular immunity could be transferred to normal mice by SiRNA either via in vivo or in vitro sensitization. Intraperitoneal inoculation of SiRNA to normal mice may result in production of specific antibodies.
Wu
G Z
GZ
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine.
Liu
S X
SX
Xu
Y X
YX
D000818:Animals; D000917:Antibody Formation; D000947:Antigens, Helminth / Q000276:immunology; D002464:Cell Migration Inhibition; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D007111:Immunity, Cellular; D051379:Mice; D012313:RNA / Q000276:immunology*; D012549:Schistosoma japonicum / Q000276:immunology*
D000947:Antigens, Helminth; C013674:RNA, immune; D012313:RNA