[Selection of antigenic variants of the influenza virus on the cells of different hosts].
Antigenic differences were found in influenza B virus variants isolated and propagated in different systems: chick embryos (E variants) and MDCK cell culture (M variants). The antigenic differences in M and E variants were detected in HI tests with polyclonal mouse sera and monoclonal antibodies as well as in biological neutralization tests in chick embryos and MDCK cell culture, and confirmed when M and E variants were used as antigens for antibody detection in human sera. By protein mobility in PAGE, M and E variants did not differ from each other and were also identical with the reference B/Victoria/87 strain.
Shenderovich
S F
SF
Feklisova
L V
LV
Smirnov
Iu A
IuA
Kuznetsova
M A
MA
D000818:Animals; D000911:Antibodies, Monoclonal; D000940:Antigenic Variation / Q000276:immunology*; D000956:Antigens, Viral / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000032:analysis; D006382:Hemadsorption / Q000276:immunology; D006385:Hemagglutination Inhibition Tests; D006389:Hemagglutinins, Viral / Q000276:immunology; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D009500:Neutralization Tests; D051381:Rats; D014764:Viral Proteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D000939:Epitopes; D006389:Hemagglutinins, Viral; D014764:Viral Proteins
Selektsiia antigennykh variantov virusa grippa na kletkakh raznykh khoziaev.