Treatment of experimental alveolar echinococcosis: comparative study of mebendazole, isoprinosine and a mebendazole isoprinosine association.
A comparative biochemical study of the effects of mebendazole and Isoprinosine used separately or associated was conducted in six-month old gerbils infected three months ago by Echinococcus multilocularis metacestodes. Mebendazole treatment induced a decrease of glucose (81%) whereas Isoprinosine increased the glucose uptake in the parasite. The combination of the two drugs led to a decrease of about 40% of the glucose concentration. The specific activities of alkaline and acid phosphatases were also modified. Isoprinosine seemed more effective when used alone than associated with mebendazole with the chosen procedure of treatment.
Sarciron
M E
ME
Department of Parasitology, Claude-Bernard University, Lyon, France.
al-Nahhas
S
S
Walbaum
S
S
Raynaud
G
G
Petavy
A F
AF
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004359:Drug Therapy, Combination; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D004446:Echinococcus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005260:Female; D005849:Gerbillinae; D005947:Glucose / Q000378:metabolism; D007542:Inosine Pranobex / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008463:Mebendazole / Q000494:pharmacology / Q000627:therapeutic use*
D008463:Mebendazole; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005947:Glucose; D007542:Inosine Pranobex