The inhibitory effect of 3,3',4,5'-tetrahydroxystilbene, a constituent of Cassia garrettiana, on anti-IgE-induced histamine release from human basophils in vitro.
3,3',4,5'-Tetrahydroxystilbene (I), a constituent of Cassia garrettiana, strongly inhibited the anti-IgE-induced histamine release from human basophils in vitro at concentrations of 3 to 30 microM. Considering that disodium cromoglycate showed no significant inhibitory activity in this assay method, the strong effect of I should be emphasized.
Inamori
Y
Y
Osaka University of Pharmaceutical Sciences, Japan.
Ogawa
M
M
Tsujibo
H
H
Baba
K
K
Kozawa
M
M
Nakamura
H
H
D001491:Basophils / Q000187:drug effects* / Q000276:immunology; D002366:Cassia / Q000032:analysis*; D006636:Histamine Release / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D066298:In Vitro Techniques; D010946:Plants, Medicinal; D013267:Stilbenes / Q000494:pharmacology*
D013267:Stilbenes; D007073:Immunoglobulin E; C041525:3,3',4,5'-tetrahydroxystilbene