[The use of monoclonal antibodies to cytokeratin peptides for the diagnosis of basal cell carcinoma of the skin].
25 skin basaliomas were studied immunohistochemically using 6 different monoclonal antibodies (MAB) to the low-molecular cytokeratins N 8, 18 (according to Moll's catalog) as well as to the cytokeratins N 1, 2, 9, 10, 11 and N 17. Prekeratin N 17 was found in all tumours while cytokeratin N 18 was found in no tumour. Prekeratin N 8 was expressed in 24% of tumours. MAB EE 21-06 to the cytokeratin N 1, 2, 9, 10, 11 are reactive with tumour cells in 20% of cases. Basalioma cells (apart from trichobasalioma) did not react with MAB G 36-19. These results suggest a dissimilar origin of basaliomas and may help in the differential diagnosis of the skin malignant tumours.
Petrov
S V
SV
Raĭkhlin
N T
NT
Serre
G
G
D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D002280:Basal Cell Carcinoma / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012878:Skin Neoplasms / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D007633:Keratins
Primenenie monoklonal'nykh antitel i tsitokeratinovym peptidam dlia diagnostiki bazal'nokletochnogo raka kozhi.