title: The shiverer mouse mutation shi/shi: rescue and preimplantation detection.
abstract: The shiverer mouse mutation has been used as a model in this series of experiments. Germ-line therapy of this disorder has been demonstrated by producing mice transgenic for the wild-type gene for myelin basic protein (MBP). The mutation has also been diagnosed in preimplantation mouse blastocysts.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena 91125.
authors.forename: C
authors.initials: C
authors.lastname: Readhead
authors.forename: A L
authors.initials: AL
authors.lastname: Muggleton-Harris
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000473:pathology; D005260:Female; D015316:Genetic Therapy; D051379:Mice; D008818:Mice, Neurologic Mutants; D008822:Mice, Transgenic; D004676:Myelin Basic Protein / Q000235:genetics; D009900:Optic Nerve / Q000648:ultrastructure; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D014202:Tremor / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*
chemical_list: D004676:Myelin Basic Protein