title: Cytokeratin polypeptide expression in a cloacogenic carcinoma and in the normal anal canal epithelium.
abstract: The aim of the present study was to explore the origin of cloacogenic carcinoma in the anal canal by immunohistochemical methods. We compared cytokeratin polypeptide expression of a cloacogenic carcinoma to normal and epithelia, to anal squamous cell carcinoma and to basal and squamous cell carcinoma of the skin, using a battery of monoclonal anti-cytokeratin, polypeptide-specific antibodies. Our results indicate that cloacogenic carcinoma expresses cytokeratin polypeptides similar to those of the basal layer of anal squamous epithelium, of the anal transitional zone epithelium and of a layer of basal cells in the anal glands. Thus we concluded that each of the above cell types may be the cell of origin of cloacogenic carcinoma.
authors.affiliation: Department of Pathology, Faculty of Medicine, Technion, Haifa, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Levy
authors.forename: B
authors.initials: B
authors.lastname: Czernobilsky
authors.forename: B
authors.initials: B
authors.lastname: Geiger
mesh_terms: D001003:Anal Canal / Q000737:chemistry* / Q000166:cytology; D000911:Antibodies, Monoclonal; D001005:Anus Neoplasms / Q000737:chemistry* / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000473:pathology; D004847:Epithelial Cells; D004848:Epithelium / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000737:chemistry* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D007633:Keratins