title: [The modular image analysis computer for assessment of prognosis in testicular tumors].
abstract: Since 1981 a total of 107 patients with non-seminomatous germ cell tumors of the testis (NSGCT) in clinical stage I were assigned to a "wait and see" protocol. At a median follow-up of 40 months (4-100) thirty seven pts. (35%) relapsed with 84% of these within the first year. Employing the Hedley-technique out of 50 primary tumor-tissues available nuclear suspensions were obtained, staining according to the DNA-Feulgen-procedure and evaluated by the modular image analysis computer (MIAC, Leitz, FRG). In 67% hyperpentaploidy was found in the cases with progression while only 23% exhibited a greater than 5c-rate in the NED-group. With logistic regression achieving a p-value of 0.0296 hyperpentaploidy has to be considered a significant prognosticator in NSGCT/CS I.
authors.affiliation: Klinik für Urologie, Medizinischen Hochschule Hannover.
authors.forename: E
authors.initials: E
authors.lastname: Allhoff
authors.forename: C
authors.initials: C
authors.lastname: Wittekind
authors.forename: S
authors.initials: S
authors.lastname: Liedke
authors.forename: H
authors.initials: H
authors.lastname: Tanke
authors.forename: U
authors.initials: U
authors.lastname: Jonas
mesh_terms: D004407:Dysgerminoma / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D012984:Software; D013736:Testicular Neoplasms / Q000473:pathology*
vernacular_title: Der Modular Image Analysis Computer in der Prognoseerfassung bei Hodentumoren.