title: Clear cell basal cell carcinoma.
abstract: We describe a case of clear cell basal cell carcinoma of the superficial type, presenting as a crusted eruption on the abdomen. Histological examination showed a solid proliferation of clear cells attached to the under-surface of an atrophied epidermis. In addition, distinct pagetoid infiltration was seen within the overlying epidermis. A focal connection between the clear cell portion and a deeper lying nodular basal cell carcinoma was demonstrated, elucidating the true nature of the lesion. Immunohistochemical studies and electronmicroscopy confirmed the epithelial derivation of the tumour. The clear cell appearance was due to multiple cytoplasmic electronlucent vacuoles which were not surrounded by membranes.
authors.affiliation: Department of Dermatology, Academic Hospital, Free University, Amsterdam, The Netherlands.
authors.forename: T M
authors.initials: TM
authors.lastname: Starink
authors.forename: C E
authors.initials: CE
authors.lastname: Blomjous
authors.forename: T J
authors.initials: TJ
authors.lastname: Stoof
authors.forename: J C
authors.initials: JC
authors.lastname: Van Der Linden
mesh_terms: D000005:Abdomen; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D015388:Organelles / Q000648:ultrastructure; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins