Significance of soluble Fc epsilon receptor II (sFc epsilon RII/CD23) in serum and possible application of sFc epsilon RII for the prevention of allergic reactions.
The significance of sFc epsilon RII in IgE-mediated allergic disease was examined. sFc epsilon RII in serum was found to decrease following clinical improvement, suggesting sFc epsilon RII in serum may be an indicator of allergic diseases. Significant proportions of sFc epsilon RII in serum were present as complexes with IgE in normals as well as in atopic patients, and these complexes were more prominent in the former than in the latter group. From these observations, attempts were made to inhibit IgE-mediated allergic reactions in vitro employing recombinant sFc epsilon RII. sFc epsilon RII inhibited IgE-binding as well as IgE-mediated release of chemical mediators from Fc epsilon RI and Fc epsilon RII expressing cells. These results show the functional significance of sFc epsilon RII in the negative regulation of IgE-mediated allergic reactions.
Suemura
M
M
Third Department of Internal Medicine, Osaka University, Japan.
Kikutani
H
H
Sugiyama
K
K
Uchibayashi
N
N
Aitani
M
M
Kuritani
T
T
Barsumian
E L
EL
Yamatodani
A
A
Kishimoto
T
T
D015703:Antigens, CD / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000097:blood* / Q000378:metabolism; D001491:Basophils / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D006636:Histamine Release; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000378:metabolism / Q000502:physiology; D007372:Interferons / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D009000:Monocytes / Q000378:metabolism; D011961:Receptors, Fc / Q000097:blood* / Q000378:metabolism; D017455:Receptors, IgE; D012397:Rosette Formation
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D011961:Receptors, Fc; D017455:Receptors, IgE; D015847:Interleukin-4; D007073:Immunoglobulin E; D007372:Interferons