Carbohydrate antigens on cancer-associated mucin-like molecules.
Mucins are large molecular weight glycoproteins characterized by carbohydrate sugars attached via 'O-glycosidic' linkages to serine or threonine. Mucins are synthesized by a variety of epithelial tissues as membrane-bound or secreted proteins, encoded by several distinct mucin genes. Numerous alterations of mucin-associated carbohydrates can be detected in neoplastic epithelial tissues and on circulating mucins in patients with adenocarcinomas. The expression of various sialyosylated-carbohydrate epitopes may correlate with poor prognosis and enhanced metastatic disease in colorectal adenocarcinomas. Mucin-associated carbohydrate and peptide antigens are currently being investigated for their role in cancer diagnosis, monitoring for progression or metastases, immunotherapy and immunosuppression.
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Department of Gastroenterology, University of Minnesota, Minneapolis.
Kim
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D000230:Adenocarcinoma / Q000276:immunology; D000595:Amino Acid Sequence; D000951:Antigens, Neoplasm / Q000737:chemistry*; D002240:Carbohydrate Sequence; D000939:Epitopes; D005752:Gastric Mucins; D006801:Humans; D008969:Molecular Sequence Data; D009077:Mucins / Q000235:genetics / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D010455:Peptides / Q000235:genetics / Q000276:immunology
D000951:Antigens, Neoplasm; D000939:Epitopes; D005752:Gastric Mucins; D009077:Mucins; D010455:Peptides; C053366:apomucin