[Massive pulmonary embolism disclosing thrombocytopenia induced by low molecular weight heparin. Therapeutic success of prostacyclin].
The authors report a case of massive pulmonary embolism revealing thrombocytopenia induced by a low molecular weight heparin (LMWH) initially proposed for the treatment of superficial phlebitis. The diagnosis was confirmed by in vitro aggregation tests and a fall in the platelet count when the LMWH was reintroduced. The outcome was clinically, angiographically and hematologically satisfactory in response to in situ treatment with prostaglandin, subsequently replaced by Vitamin K antagonists.
Metz
D
D
Service de Cardiologie, CHR Robert Debré, Reims.
N'Guyen
P
P
Chapoutot
L
L
Graciet
J
J
Taupin
J M
JM
Grentzinger
A
A
Elaerts
J
J
Bajolet
A
A
D005340:Fibrinogen / Q000032:analysis; D006495:Heparin, Low-Molecular-Weight / Q000009:adverse effects*; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010689:Phlebitis / Q000188:drug therapy; D010976:Platelet Count; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D011859:Radiography; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications*
D006495:Heparin, Low-Molecular-Weight; D005340:Fibrinogen; D016285:Iloprost
Embolie pulmonaire massive révélant une thrombopénie induite par héparine de bas poids moléculaire. Succès thérapeutique d'une prostacycline.