title: The new potent immunosuppressant FK-506 reverses multidrug resistance in Chinese hamster ovary cells.
abstract: The macrolide FK-506, produced by Streptomyces tsukubaensis, is effective in sensitizing a multidrug resistant strain of Chinese hamster ovary cells to the cytotoxic action of vinblastine. FK-506 also promotes Adriamycin accumulation into both wild type and resistant cell lines. FK-506 may be a useful drug to enhance the effectiveness of anti-tumour cytotoxic drugs.
authors.affiliation: Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
authors.forename: R F
authors.initials: RF
authors.lastname: Epand
authors.forename: R M
authors.initials: RM
authors.lastname: Epand
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000378:metabolism; D004351:Drug Resistance; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016559:Tacrolimus; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D014747:Vinblastine; D004317:Doxorubicin; D016559:Tacrolimus