title: Studies on the prenatal chromosomal analysis and the changes of maternal serum alpha-fetoprotein following chorionic villus sampling.
abstract: Transcervical chorionic villus sampling (CVS) was performed in 174 patients between 7 & 12 menstrual weeks of pregnancy opting for prenatal diagnosis. Advanced maternal age was the most common indication for CVS (39.7%). The sampling success rate was 95.4% (166/174), representing 88.9% at 7 to 8 weeks, 98.9% at 9 to 10 weeks & 92.7% at 11 to 12 weeks gestation. In 139 of 174 patients (80%), successful sampling was accomplished in one or two catheter passages only. Four spontaneous fetal losses (2.3%) occurred. The cytogenetic analysis routinely used was the direct overnight & long-term culture methods which revealed 4 abnormalities (2.4%). To date, 90 of the women have been delivered & all infants are doing well and the remaining 65 pregnancies are continuing uneventually. Maternal serum alphafetoprotein (MSAFP) concentration was determined in 72 patients immediately before & after CVS. A significant increase of 20% or more, comparable to pre CVS levels, was noted immediately after sampling in 56 of 72 patients (77.8%). The increase in MSAFP concentration correlated with the amount of villi sampled (r = 0.498, p less than 0.001) & with the number of sampling attempts (p less than 0.05). Estimated CVS related fetomaternal hemorrhage (FMH) ranged from 0.005 to 0.1552 ml and in 5 of 72 patients (6.90%) 0.06 ml or more of FMH was noted. Two of the 5 patients had FMH of 0.1 ml or more.
authors.affiliation: Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Y H
authors.initials: YH
authors.lastname: Yang
authors.forename: M S
authors.initials: MS
authors.lastname: Lee
authors.forename: Y W
authors.initials: YW
authors.lastname: Park
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.forename: H R
authors.initials: HR
authors.lastname: Sung
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: I K
authors.initials: IK
authors.lastname: Kim
mesh_terms: D015193:Chorionic Villi Sampling / Q000009:adverse effects*; D002869:Chromosome Aberrations; D005260:Female; D005331:Fetomaternal Transfusion / Q000209:etiology; D006801:Humans; D010865:Pilot Projects; D011247:Pregnancy / Q000097:blood*; D012203:Rh Isoimmunization / Q000209:etiology; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins