title: Effect of FK-506 on heart allograft survival in the highly sensitized recipient rats as compared with ciclosporin and 15-deoxyspergualin.
abstract: The effect of FK-506 on allograft survival in unsensitized recipients has been established in several animal experimental models. In this present study, we investigated the immunosuppressive capacity of FK-506, in comparison with ciclosporin (Cs) and 15-deoxyspergualin (DSG), on heart allograft in presensitized rats. Heart grafts from male ACI rats were heterotopically transplanted to male LEW rats. All recipient rats were sensitized with donor-type whole blood admixed with immunoadjuvant (adjuvant complete Freund) 7 days prior to transplantation. FK-506, Cs and DSG were administered from day 0 to day 14 posttransplantation. The results showed that both FK-506 and Cs significantly prolonged heart allograft survival of presensitized recipients in a dose-dependent manner. The minimum effective dose in the treatment was less for FK-506 than for Cs. However, DSG showed almost no effect of prolongation in this experiment.
authors.affiliation: Department of Urology, Osaka University Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.forename: S
authors.initials: S
authors.lastname: Takahara
authors.forename: M
authors.initials: M
authors.lastname: Kyo
authors.forename: Y
authors.initials: Y
authors.lastname: Kokado
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: T
authors.initials: T
authors.lastname: Sonoda
mesh_terms: D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D006146:Guanidines / Q000494:pharmacology*; D016027:Heart Transplantation; D007114:Immunization; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D016559:Tacrolimus / Q000494:pharmacology* / Q000633:toxicity; D014184:Transplantation, Homologous
chemical_list: D003524:Cyclosporins; D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus; D016559:Tacrolimus