[Cytogenetic and clinical features of Philadelphia chromosome positive leukemias].
The Philadelphia chromosome defines chronic myeloid leukemia, and is mostly based on a translocation t(9;22) with a typical BCR-ABL rearrangement which also occurs in so called atypical translocations. The transformation of chronic myeloid leukemia is associated with clonal evolution in 80% of cases. The appearance of an isochromosome 17q unequivocally heralds the onset of a myeloid type of blast crisis. Treatment of Ph-positive CML has still to be considered palliative except for allogeneic bone marrow transplantation. The Philadelphia chromosome is also found in about 20% of patients with acute lymphoblastic leukemia and in about 2% of patients with nonlymphoblastic leukemia. It is associated with a poor prognosis. Molecular and cytogenetic findings help differentiating between de novo acute leukemia and blast crisis of chronic myeloid leukemia.
Becher
R
R
Innere Universitäts- und Poliklinik (Tumorforschung) Westdeutsches Tumorzentrum, Essen.
Kloke
O
O
D001752:Blast Crisis / Q000235:genetics / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000145:classification / Q000235:genetics* / Q000473:pathology; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic
Zytogenetik und Klinik der Philadelphia Chromosom positiven Leukämien.