[The protease inhibitor treatment of the disseminated intravascular coagulation syndrome in patients with liver cirrhosis].
The results of the treatment of the syndrome of disseminated intravascular coagulopathy (DIC) in 41 patients with liver cirrhosis are reported. A relation between the severity of the liver impairment and the degree of the increase of the fibrin split products (FSP) was established. FSP above 100 micrograms/ml were found in patients with III class liver failure according to Child-Turcotte-Pugh and rating above 6.5 according to Z. Krŭstev. The administration of 30,000-60,000 U of the protease inhibitor contrykal led to mastering of the hemorrhagic diathesis in 19 of 21 patients (group A). The increased FSP in the serum fell (chi 2 = 5.79; p less than 0.001). In contrast, the administration of PAMBA and styptanon did not affect the hemorrhagic diathesis and DIC syndrome in 16 of 20 other patients (group B--chi 3 = 20.54; p less than 0.001). The authors recommend protease inhibitors as the treatment of choice of DIC syndrome in liver cirrhosis. Only in case of lack of effect should heparin be added.
Mateva
L
L
Donkova
O
O
D010129:4-Aminobenzoic Acid / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D007611:Aprotinin / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D004341:Drug Evaluation; D004964:Estriol / Q000627:therapeutic use / Q000031:analogs & derivatives; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy*; D011480:Protease Inhibitors / Q000627:therapeutic use*; D062366:para-Aminobenzoates
D000933:Antifibrinolytic Agents; D011480:Protease Inhibitors; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D007611:Aprotinin; C009341:estriol succinate; D004964:Estriol; D010129:4-Aminobenzoic Acid
Lechenie s proteazni inkhibitori na sindroma na diseminirana intravazalna koagulatsiia pri bolni s chernodrobna tsiroza.