title: Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast.
abstract: Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.
authors.affiliation: Institute of Anatomic Pathology, University of Bologna, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Eusebi
authors.forename: M G
authors.initials: MG
authors.lastname: Cattani
authors.forename: J
authors.initials: J
authors.lastname: Lamovec
authors.forename: D
authors.initials: D
authors.lastname: Treré
authors.forename: C
authors.initials: C
authors.lastname: Ceccarelli
authors.forename: P
authors.initials: P
authors.lastname: Veronesi
authors.forename: C
authors.initials: C
authors.lastname: Clemente
authors.forename: M
authors.initials: M
authors.lastname: Derenzini
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000737:chemistry; D012834:Silver; D013194:Staining and Labeling / Q000379:methods; D015996:Survival Rate
chemical_list: D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D012834:Silver