Porin interaction with hexokinase and glycerol kinase: metabolic microcompartmentation at the outer mitochondrial membrane.
Porin is the pore-forming protein involved in the movement of adenine nucleotides across the outer mitochondrial membrane (OMM). Hexokinase and glycerol kinase interact with porin on the outer surface of the OMM in a manner which provides these enzymes with preferred access to the ATP generated in the mitochondrion. We review recent evidence which permits refinement of our knowledge of these proteins and their interactions at the OMM. The involvement of this system in metabolic microcompartmentation is discussed, as well as possible pathological consequences of its disruption in malignancy and genetic deficiencies of hexokinase, glycerol kinase, and porin.
Adams
V
V
Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.
Griffin
L
L
Towbin
J
J
Gelb
B
B
Worley
K
K
McCabe
E R
ER
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D005991:Glycerol Kinase / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels; D008928:Mitochondria / Q000378:metabolism; D018272:Porins
D000227:Adenine Nucleotides; D001425:Bacterial Outer Membrane Proteins; D007473:Ion Channels; D018272:Porins; D006593:Hexokinase; D005991:Glycerol Kinase