Radioprotective effects of (-)-epigallocatechin 3-O-gallate (green-tea tannin) in mice.
Long-term administration of (-)-epigallocatechin 3-O-gallate (EGCG) to mice through drinking water prevented radiation-induced increase of lipid peroxides in liver and significantly prolonged life span after lethal whole-body X-irradiation. The result indicates validity of this green-tea component as an orally active radio-protector of very low toxicity.
Uchida
S
S
Yutoku Pharmaceutical Ind. Co., Kashima-shi, Japan.
Ozaki
M
M
Suzuki
K
K
Shikita
M
M
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002455:Cell Division; D002478:Cells, Cultured; D006367:HeLa Cells / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism / Q000528:radiation effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013634:Tannins / Q000494:pharmacology
D016587:Antimutagenic Agents; D008054:Lipid Peroxides; D011837:Radiation-Protective Agents; D013634:Tannins; D002392:Catechin; C045651:epigallocatechin gallate