Haloperidol treatment increases D2 dopamine receptor protein independently of RNA levels in mice.
Haloperidol, administered to mice in their drinking water, produced a 21% increase in striatal D2 dopamine receptor density after seven days of continuous exposure. The steady-state D2 receptor RNA prevalence was unaffected by this treatment, yet the RNA coding for preproenkephalin was elevated, as expected. These data indicate that the homologous up-regulation of dopamine receptor density by antipsychotic drugs proceeds by mechanisms other than changes in RNA abundance.
Goss
J R
JR
Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191.
Kelly
A B
AB
Johnson
S A
SA
Morgan
D G
DG
D000818:Animals; D015152:Blotting, Northern; D005786:Gene Expression Regulation / Q000187:drug effects; D006220:Haloperidol / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011954:Receptors, Dopamine / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors; D014158:Transcription, Genetic; D015854:Up-Regulation / Q000187:drug effects
D012333:RNA, Messenger; D011954:Receptors, Dopamine; D012313:RNA; D006220:Haloperidol