[The characterization of the spectrum of the antibody response to Mycobacterium tuberculosis antigenic determinants by immunoblotting].
The spectrum of antibody response to M. tuberculosis antigenic determinants H37Rv and M. bovis antigenic determinants BCG was studied in serum samples from 33 healthy donors and 31 patients with infiltrative pulmonary tuberculosis by the method of immunoblotting. The study revealed that most frequently tuberculosis patients showed response to Ag-H37Rv with molecular weights of 52, 39, 35, 21, 31, 68 kD (44.4-22.2%) and Ag-BCG with molecular weights 60, 58, 50, 25, 54, 70 kD. (33.3-22.2%). By month 9 of effective chemotherapy binding predominantly with Ag-H37Rv determinants of 31, 62, 35, 75, 56, 28, 19, 5, 13 kD (75-37.5%) and Ag-BCG determinants of 13, 34, 38, 44, 19, 36, 45, 52, 58, 60 70 kD (37.5-25%) were registered. Some differences in the spectra of antibody response to Ag-H37Rv and Ag-BCG determinants were noted.
Kiroshka
V S
VS
Shinkareva
T I
TI
Litvinov
V I
VI
Chernousova
L N
LN
Ginda
S S
SS
Gil'burd
B Sh
BSh
D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting / Q000379:methods; D008970:Molecular Weight; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000939:Epitopes
Kharakteristika spektra antitel'nogo otveta na antigennye determinanty Mycobacterium tuberculosis metodom immunoblottinga.