[The effect of amino acids on neurotransmitter metabolites in the cerebrospinal fluid].
Metabolites of neurotransmitters of dopamine, homomovanillic acid (HVA), and of serotonin, 5-hydroxyindole acetic acid (5-HIAA), were assessed in cerebrospinal fluid by the method of high pressure liquid chromatography with electrochemical detection. The HVA concentration in cerebrospinal fluid rose markedly in a two-month-old infant with intracranial hypertension caused by a communicating hyporesorptive hydrocephalus following administration of tyrosine, the precursor of dopamine. The 5-HIAA concentration in cerebrospinal fluid rose significantly in a 20-month-old boy with epilepsy and arrested psychomotor development after administration of 5-hydroxytryptophan, the precursor of dopamine. Biochemical normalization of concentrations of neurotransmiteed metabolites did not lead to changes in the clinical condition of the children.
Zeman
J
J
IV. dĕtská klinika 1. lékarské fakulty Univerzity Karlovy, Praha.
Böswart
J
J
D002675:Child, Preschool; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007223:Infant; D008297:Male; D014364:Tryptophan / Q000494:pharmacology*; D014443:Tyrosine / Q000494:pharmacology*
D014443:Tyrosine; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D006719:Homovanillic Acid
Vliv aminokyselin na metabolity neurotransmiterů v likvoru.