[Experimental study of protective effect of solcoseryl on cisplatin nephrotoxicity].
Cis-diamminedichloroplatinum (II) (cisplatin) is known to possess nephrotoxicity. Recently, it is said that the nephrotoxicity closely correlated with active oxygen. In the present study, an attempt was made to examine, whether or not solcoseryl, antioxidant like scavenger, decreases the nephrotoxicity. Three groups of Sprague-dawley rats were injected cisplatin (3mg/kg) only (C group), cisplatin and 2 times solcoseryl (8mg/kg), (CS2 group), and cisplatin and 5 times solcoseryl (CS5 group). BUN levels in C and CS2 groups were elevated compared to CS5 group. In the light microscopy, 62.5% to 100% in C and CS2 groups revealed massive necrosis in straight part of the proximal tubules, while the damage in CS5 group was only 25%. In the electron microscopy, these findings were similar to the light microscopic observations. Solcoseryl is known to have several antioxidative effects such as inhibition of superoxide producing and hyperperoxidation. It is suggested that these effects of solcoseryl might decrease the nephrotoxicity. Solcoseryl seems to be a useful drug for reducing nephrotoxicity and also it is a safe drug. Therefore, solcoseryl can be used for the prevention of cisplatin nephrotoxicity.
Satoh
H
H
Department of Pathology, Dokkyo University School of Medicine, Koshigaya, Japan.
Mori
Y
Y
D000183:Actihaemyl / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D002945:Cisplatin / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007684:Kidney Tubules / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000183:Actihaemyl; D002945:Cisplatin