Synthesis and biochemical studies of dithioate DNA.
Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in HeLa cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.
Caruthers
M H
MH
Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.
Beaton
G
G
Cummins
L
L
Graff
D
D
Ma
Y X
YX
Marshall
W S
WS
Sasmor
H
H
Norris
P
P
Yau
E K
EK
D001483:Base Sequence; D004247:DNA / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006678:HIV / Q000201:enzymology; D008969:Molecular Sequence Data; D018894:Reverse Transcriptase Inhibitors; D016914:Ribonuclease H / Q000378:metabolism; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
D018894:Reverse Transcriptase Inhibitors; D013873:Thionucleotides; D004247:DNA; D016914:Ribonuclease H