HMB-45 reactivity in adrenal pheochromocytomas.
Melanoma-specific antibody (HMB-45) is highly specific for junctional nevi, malignant melanomas, and related lesions. Rarely have other benign or neoplastic tissues demonstrated positivity with the monoclonal antibody following purification. In the present study, four of 12 pheochromocytomas contained chief cells that reacted with HMB-45. We discuss the clinical and pathologic implications of this finding.
Unger
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PD
Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, City University of New York.
Hoffman
K
K
Thung
S N
SN
Pertsemlides
D
D
Wolfe
D
D
Kaneko
M
M
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000276:immunology* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000276:immunology* / Q000473:pathology*
D000911:Antibodies, Monoclonal