title: Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP).
authors.affiliation: Department of Synthetic Chemical Research, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
authors.forename: J M
authors.initials: JM
authors.lastname: Balkovec
authors.forename: R M
authors.initials: RM
authors.lastname: Black
authors.forename: M L
authors.initials: ML
authors.lastname: Hammond
authors.forename: J V
authors.initials: JV
authors.lastname: Heck
authors.forename: R A
authors.initials: RA
authors.lastname: Zambias
authors.forename: G
authors.initials: G
authors.lastname: Abruzzo
authors.forename: K
authors.initials: K
authors.lastname: Bartizal
authors.forename: H
authors.initials: H
authors.lastname: Kropp
authors.forename: C
authors.initials: C
authors.lastname: Trainor
authors.forename: R E
authors.initials: RE
authors.lastname: Schwartz
mesh_terms: D000107:Acetylation; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D054714:Echinocandins; D006801:Humans; D051379:Mice; D008811:Mice, Inbred DBA; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D010456:Peptides, Cyclic; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; D011355:Prodrugs; C042101:cilofungin