Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine.
A cDNA clone encoding the N-terminal sequence of the murine integrin beta 7 subunit, a novel member of the leukocyte cell adhesion molecule subset (Leu-CAM), has been isolated. An N-terminal region of 13 contiguous amino acids deduced from the cDNA shows complete identity with the N-terminus of the 120 kDa subunit of the M290 antigen, a surface molecule found highly expressed on mouse intestinal intraepithelial lymphocytes (IEL). This unexpected result focuses two previously unconnected areas of research and suggests that integrins may have a special role to play in the defence of the gut mucosa.
Yuan
Q
Q
Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand.
Jiang
W M
WM
Hollander
D
D
Leung
E
E
Watson
J D
JD
Krissansen
G W
GW
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D015152:Blotting, Northern; D004247:DNA / Q000235:genetics; D004848:Epithelium / Q000276:immunology; D015723:Gene Library; D006801:Humans; D016023:Integrins / Q000235:genetics*; D007413:Intestinal Mucosa / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D046911:Macromolecular Substances; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
D000954:Antigens, Surface; D016023:Integrins; D046911:Macromolecular Substances; D012313:RNA; D004247:DNA