title: [Effects of tumor necrosis factor on the tonus of cerebral arteries].
abstract: It was determined that tumor necrosis factor (TNF) is capable of decreasing the local brain's blood flow on 45.6% (in the concentration of 6 micrograms/kg); to make a spasm of the pial arteries on 39.6%. In vitro experiments TNF increased the amplitude of the rhythmical and the tonic contractions of the brain's arteries smooth muscles (3.6 X 10(-8) M). The direct action of the TNF in the vascular wall is endothelium-dependent.
authors.forename: A L
authors.initials: AL
authors.lastname: Azin
authors.forename: N P
authors.initials: NP
authors.lastname: Mitagvariia
authors.forename: V G
authors.initials: VG
authors.lastname: Medvedev
authors.forename: I K
authors.initials: IK
authors.lastname: Baratashvili
authors.forename: A S
authors.initials: AS
authors.lastname: Barybin
mesh_terms: D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009389:Neovascularization, Pathologic; D010841:Pia Mater / Q000098:blood supply; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D014409:Tumor Necrosis Factor-alpha
vernacular_title: Vliianie tumornekrotiziruiushchego faktora na tonus arteriĭ golovnogo mozga.