Vasoactive intestinal polypeptide in dorsal root terminals of the rat spinal cord is regulated by the axoplasmic transport in the peripheral nerve.
Vasoactive intestinal polypeptide (VIP) immunoreactivity in the upper spinal dorsal horn is markedly increased after transection, crush or vinblastine treatment of the ipsilateral, segmentally related peripheral nerve. After regeneration of the peripheral nerve, VIP disappears from the upper dorsal horn. Transection-induced VIP increase is abolished by rhizotomy. It is concluded that the expression of VIP is restricted by factor(s) carried by retrograde axoplasmic transport to dorsal root ganglion cells.
Knyihár-Csillik
E
E
Department of Anatomy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Kreutzberg
G W
GW
Raivich
G
G
Csillik
B
B
D000818:Animals; D001370:Axonal Transport; D005260:Female; D008297:Male; D009409:Nerve Crush; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012584:Sciatic Nerve / Q000502:physiology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000187:drug effects / Q000502:physiology*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*; D014747:Vinblastine / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D014747:Vinblastine