[Indomethacin inhalation therapy].
We studied the effect indomethacin (IND) on electrical properties of airway epithelial cells and on sputum production in patients with chronic respiratory infection. Addition of IND (3 x 10(-6) M) to the mucosal side of Ussing chamber reduced short-circuit current from 5.9 +/- 1.2 to 1.7 +/- 0.5 microA/cm2 (p less than 0.001, n = 12) in canine cultured tracheal epithelium, an effect that was dependent on CI. Inhalation of IND for two weeks resulted in a decrease in the amount of sputum from 208 +/- 25 to 102 +/- 19 ml/day, (p less than 0.01, n = 13), and the concentrations of cyclooxygenase products in the sputum without alteration of inflammatory parameters. These results indicate that IND inhalation is a promising therapy in improving excessive sputum production and that this effect may be attributable to inhibition of Cl secretion and the subsequent reduction in water movement toward the airway lumen.
Tamaoki
J
J
First Department of Medicine, Tokyo Women's Medical College.
D000280:Administration, Inhalation; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001988:Bronchiolitis / Q000188:drug therapy / Q000503:physiopathology; D004285:Dogs; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000494:pharmacology; D007473:Ion Channels / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000503:physiopathology; D015222:Sodium Channels / Q000378:metabolism; D013183:Sputum / Q000187:drug effects / Q000378:metabolism*; D014132:Trachea / Q000187:drug effects / Q000378:metabolism
D007473:Ion Channels; D015222:Sodium Channels; D007213:Indomethacin