title: Basic fibroblast growth factor promotes in vivo cerebral angiogenesis in chronic forebrain ischemia.
abstract: This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.
authors.affiliation: Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55905.
authors.forename: M K
authors.initials: MK
authors.lastname: Lyons
authors.forename: R E
authors.initials: RE
authors.lastname: Anderson
authors.forename: F B
authors.initials: FB
authors.lastname: Meyer
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology; D002196:Capillaries / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002339:Carotid Arteries / Q000502:physiology; D002540:Cerebral Cortex / Q000473:pathology; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007276:Injections, Intraventricular; D008297:Male; D009389:Neovascularization, Pathologic / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D010100:Oxygen / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016222:Fibroblast Growth Factor 2; D002245:Carbon Dioxide; D010100:Oxygen