Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs.
The influence of aerosols of Ruthenium red (RR) on capsaicin- and citric acid-induced cough was investigated in guinea pigs. Aerosols of RR (0.3, 1, 3%) reduced capsaicin-induced cough in dose-dependent manner. Inhalation of RR also reduced cough produced by low, (200 mM) but not high (550 mM), concentrations of citric acid. These data suggest that RR is not a specific capsaicin antagonist and that citric acid and capsaicin share a common mechanism for activation of airway C-fibers that is RR sensitive. Furthermore, high concentrations of citric acid can elicit cough through a RR-insensitive mechanism.
Bolser
D C
DC
Department of Allergy, Schering-Plough Research, Bloomfield, NJ 07003.
Aziz
S M
SM
Chapman
R W
RW
D000336:Aerosols; D000818:Animals; D002211:Capsaicin; D002951:Citrates; D019343:Citric Acid; D003371:Cough / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D009994:Osmolar Concentration; D012430:Ruthenium Red / Q000494:pharmacology*
D000336:Aerosols; D002951:Citrates; D012430:Ruthenium Red; D019343:Citric Acid; D002211:Capsaicin