title: Immune enhancement of a polysaccharides peptides isolated from Coriolus versicolor.
abstract: A protein-bound polysaccharides (PSP) isolated from Coriolus versicolor in Shanghai, at the concentrations of 100-800 micrograms/ml promoted lymphocyte proliferation. PSP 25 mg/kg ip into mice for 5 d antagonized the inhibition of IL-2 production by cyclophosphamide from activated T lymphocytes and restored the suppressed T-cell-mediated delayed, type hypersensitivity response to normal. PSP 10-1000 micrograms/ml induced interferon alpha and gamma production from human peripheral leukocytes 4 and 8 times respectively higher than that of the control groups. Moreover, PSP also increased phagocytic functions of host reticulo-endothelial system. The results suggest that the anti-tumor effects of PSP may be related to its potentiation of host immunological responses.
authors.affiliation: Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
authors.forename: X Y
authors.initials: XY
authors.lastname: Li
authors.forename: J F
authors.initials: JF
authors.lastname: Wang
authors.forename: P P
authors.initials: PP
authors.lastname: Zhu
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: J B
authors.initials: JB
authors.lastname: Ge
authors.forename: S X
authors.initials: SX
authors.lastname: Yang
mesh_terms: D000818:Animals; D005260:Female; D005658:Fungi; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007155:Immunologic Factors / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007155:Immunologic Factors; D007376:Interleukin-2; D011134:Polysaccharides; D007372:Interferons