Examination of the role of the colloids hydroxyethylstarch, dextran, human albumin, and plasma proteins in a modified UW solution.
The delayed contralateral nephrectomy procedure (three-step) produced inconsistent results, indicating that the preserved autotransplanted kidney tends to remain unfunctional and to regenerate incompletely unless the demand for work is placed upon it. Omission of HES in UW (UW-plain) did not affect preservation success, but resulted in increased graft edema. Substitution of HES in UW with plasma (SGF-V) or albumin (MAlb) gave significantly worse results than UW-like solutions with or without synthetic colloids. Replacement of HES in UW with UMdex-70 or UMdex-500 gave nonsignificantly worse results than UW-like solutions with or without synthetic colloids. The use of UMdex-40 as the main colloid in UW cheapened the solution, equalled the preservation success of UW and UW-plain but surpassed UW-plain in edema prevention, and exceeded UW concerning recovery of graft microcirculation.
Schlumpf
R
R
Department of Surgery, University of Minnesota, Minneapolis.
Morel
P
P
Loveras
J J
JJ
Condie
R M
RM
Matas
A
A
Kurle
J
J
Najarian
J S
JS
Sutherland
D E
DE
D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D001798:Blood Proteins; D003102:Colloids; D003911:Dextrans; D004285:Dogs; D005260:Female; D005978:Glutathione; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D007328:Insulin; D007668:Kidney; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D011887:Raffinose; D012709:Serum Albumin; D012996:Solutions
D001798:Blood Proteins; D003102:Colloids; D003911:Dextrans; D006895:Hydroxyethyl Starch Derivatives; D007328:Insulin; D019188:Organ Preservation Solutions; D012709:Serum Albumin; D012996:Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose