Axonal transport: beyond kinesin and cytoplasmic dynein.
In vitro and in vivo studies of specific neuronal fast and slow transport components are presently reshaping our understanding of how the processes of vesicular and cytoskeletal transport are regulated in axons and dendrites. Evidence suggests that vesicles possess an inherent directionality, possibly the result of their motor receptor proteins responding to intracellular cues, which then allows movement with either kinesin or cytoplasmic dynein.
Sheetz
M P
MP
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710.
Martenson
C H
CH
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism; D004398:Dyneins / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000378:metabolism*
D004398:Dyneins; D016547:Kinesins