Regulation of viral and cellular RNA turnover in cells infected by eukaryotic viruses including HIV-1.
The following reviews the role of mRNA stability in the regulation of both viral and cellular gene expression in virus-infected cells. Indeed, several eukaryotic viruses, including the human immunodeficiency virus, HIV-1, regulate cellular protein synthesis via such control mechanisms. The following systems will be discussed: (i) the degradation of viral and cellular mRNAs in cells infected by herpes simplex virus (HSV) and advances made using the HSV virion host shutoff mutant; (ii) the degradation of viral and cellular mRNA and ribosomal RNA in cells infected by vaccinia virus and the possible role of the oligoadenylate synthetase-RNase L pathways; (iii) the turnover of RNAs in cells infected by encephalomyocarditis virus, reovirus, and La Crosse virus; and finally (iv) recent studies from our laboratory on the degradation of cellular mRNAs in cells infected by HIV-1.
Katze
M G
MG
Department of Microbiology, University of Washington, Seattle.
Agy
M B
MB
D000818:Animals; D002141:Encephalitis Virus, California / Q000378:metabolism; D004686:Encephalomyocarditis virus / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism* / Q000382:microbiology; D005786:Gene Expression Regulation; D015497:HIV-1 / Q000378:metabolism; D006801:Humans; D012313:RNA / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism; D012087:Reoviridae / Q000378:metabolism; D018139:Simplexvirus / Q000378:metabolism; D014616:Vaccinia virus / Q000378:metabolism; D014777:Virus Diseases / Q000378:metabolism*; D014780:Viruses / Q000378:metabolism*
D012367:RNA, Viral; D012313:RNA