title: Tenascin expression in human dermis is related to epidermal proliferation.
abstract: The extracellular matrix glycoprotein tenascin is sparsely distributed in normal human dermis. The authors have shown that in a number of skin diseases (psoriasis, skin tumors), tenascin expression is strongly increased. In this immunohistochemical study, using polyclonal and monoclonal antisera, we have tested the hypothesis that tenascin expression in vivo is linked to epidermal proliferation. Using the sellotape stripping model in normal human skin, which causes a rapid recruitment of keratinocytes into the cell cycle, induction of tenascin expression was found in the upper dermis within 24 hours after stripping. In contrast, in normoproliferative monogenic disorders of keratinization (X-linked recessive ichthyosis, autosomal dominant ichthyosis vulgaris, non-erythrodermic lamellar ichthyosis), no increase in tenascin expression was found compared with normal skin. These findings demonstrate a relationship between epidermal proliferation and metabolic alterations in the dermal compartment.
authors.affiliation: Department of Dermatology, University Hospital Nijmegen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Schalkwijk
authors.forename: P M
authors.initials: PM
authors.lastname: Steijlen
authors.forename: I M
authors.initials: IM
authors.lastname: van Vlijmen-Willems
authors.forename: B
authors.initials: B
authors.lastname: Oosterling
authors.forename: E J
authors.initials: EJ
authors.lastname: Mackie
authors.forename: A A
authors.initials: AA
authors.lastname: Verstraeten
mesh_terms: D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics* / Q000378:metabolism; D002455:Cell Division; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D005353:Fibronectins; D015870:Gene Expression; D006801:Humans; D007057:Ichthyosis / Q000378:metabolism / Q000473:pathology; D007106:Immune Sera; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D007633:Keratins / Q000235:genetics / Q000378:metabolism; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology; D019063:Tenascin
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D007106:Immune Sera; D019063:Tenascin; D007633:Keratins