title: Scintigraphic assessment of cardiac adrenergic innervation in patients with essential hypertension.
abstract: To assess the regional cardiac adrenergic innervation in patients with essential hypertension (EHT), simultaneous iodine-123 metaiodobenzylguanidine ([123I]MIBG) and thallium-201 (201Tl) myocardial imagings were performed in five patients with EHT, seven patients with hypertrophic cardiomyopathy (HCM), and seven normal subjects. Short axial images at rest were divided into five segments: anterior, septal, posterior, lateral, and apical segments. Percent regional uptake (%RU) of 201Tl except the septal segment in patients with EHT showed no significant difference. However, the %RU of [123I]MIBG at posterior, lateral, and apical segments was significantly lower than that at anterior and septal segments in EHT. This intraimage heterogeneity of [123I]MIBG was also observed in HCM. These results suggest that there is a difference in regional adrenergic innervation of the left ventricle with myocardial hypertrophy.
authors.affiliation: 2nd Department of Internal Medicine, Ehime University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: Y
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Sumimoto
authors.forename: K
authors.initials: K
authors.lastname: Hamamoto
authors.forename: K
authors.initials: K
authors.lastname: Hiwada
mesh_terms: D019797:3-Iodobenzylguanidine; D000320:Adrenergic Fibers / Q000378:metabolism; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013565:Sympatholytics; D013794:Thallium Radioisotopes
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013565:Sympatholytics; D013794:Thallium Radioisotopes; D019797:3-Iodobenzylguanidine