[Kaposi's sarcoma in AIDS. 70 cases].
Although Kaposi's sarcoma is the most frequent of malignant diseases associated with AIDS and one of the first recognized manifestations of the syndrome, its management has not yet been standardized. This study concerns 70 AIDS patients with Kaposi's sarcoma followed up in the author's hospital department between june 1985 and december 1989. Most of these patients were homosexual or bisexual males. The mean time elapsed between the finding of a positive HIV test and the discovery of Kaposi's sarcoma was 15 +/- 3.2 months. Systematic evaluation disclosed visceral lesions in 50 percent of the patients. Chemotherapy was used in 55 cases, interferon-alpha in 23 cases and radiotherapy in 13 cases. The presence of visceral lesions clearly reduced survival time, although deaths were mainly due to opportunistic infections. Atypical forms of Kaposi's sarcoma sometimes make its diagnosis difficult, but the main problem is that of treatment, in view of the underlying immunodepression. The authors advocate the setting up of multicentre trials aimed at determining the best therapeutic approach in these patients.
Lafeuillade
A
A
Clinique des Maladies du Sang, Institut Paoli-Calmettes, Marseille.
Poizot-Martin
I
I
Dhiver
C
C
Giovannini
M
M
Viallat
J R
JR
Quilichini
R
R
Bouabdallah
R
R
Gastaut
J A
JA
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001727:Bisexuality; D001761:Bleomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005500:Follow-Up Studies; D006716:Homosexuality; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000401:mortality / Q000628:therapy
D007370:Interferon Type I; D001761:Bleomycin; D005047:Etoposide
Maladie de Kaposi au cours du SIDA. Soixante-dix observations.