Neoplastic meningitis.
Neoplastic meningitis appears to be increasing in frequency with improvements in the treatment of many cancers. It is most often recognized in patients with leukemia, breast cancer, lymphomas, and small-cell cancer of the lung, although it may be seen with virtually any malignancy. Treatment should include intrathecal chemotherapy, radiation therapy to symptomatic areas of the CNS, and optimal therapy of the systemic cancer. New efforts are underway to decrease the toxicity and improve the efficacy of antineoplastic therapy for this devastating complication of cancer.
Grossman
S A
SA
Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Moynihan
T J
TJ
D003131:Combined Modality Therapy; D006801:Humans; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D009460:Neurologic Examination; D010166:Palliative Care; D015996:Survival Rate