title: Concentration of azithromycin in human prostatic tissue.
abstract: Prostatic tissue was obtained from 36 patients at two study locations and assayed for azithromycin by HPLC or bioassay. The mean concentration of azithromycin in human prostatic tissue (2.54 micrograms/ml) 14 h after 500 mg oral dosing (two 250 mg doses 12 h apart) was much greater than plasma concentrations (less than or equal to 0.1 micrograms/ml). Azithromycin was slowly eliminated from prostatic tissue (half-life 60 h) and a mean concentration of 0.62 micrograms/ml remained 137 h after dosing.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: G
authors.initials: G
authors.lastname: Foulds
authors.forename: P
authors.initials: P
authors.lastname: Madsen
authors.forename: C
authors.initials: C
authors.lastname: Cox
authors.forename: R
authors.initials: R
authors.lastname: Shepard
authors.forename: R
authors.initials: R
authors.lastname: Johnson
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017963:Azithromycin; D002851:Chromatography, High Pressure Liquid; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D008297:Male; D011467:Prostate / Q000737:chemistry* / Q000378:metabolism; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000378:metabolism; D013997:Time Factors
chemical_list: D004917:Erythromycin; D017963:Azithromycin