title: Mammalian phosphorylating ion-motive ATPases.
abstract: The pumps discussed in this review are three members of the phosphorylating class of ion transport ATPases. They are the Na(+)-K(+)-, Ca(2+)- and H(+)-K(+)-ATPases. Recent work on their topology, possible transport mechanisms, ion-binding sites and role of the different subunits found for the Na(+)-K(+)- and H(+)-K(+)-ATPases is presented, with a suggestion of a unifying 10-membrane segment model for the catalytic subunit of this class of enzyme.
authors.affiliation: University of California Los Angeles.
authors.forename: G
authors.initials: G
authors.lastname: Sachs
authors.forename: K
authors.initials: K
authors.lastname: Munson
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001693:Biological Transport, Active; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism*; D002412:Cations / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism; D007473:Ion Channels / Q000201:enzymology*; D008565:Membrane Proteins / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010766:Phosphorylation; D011188:Potassium / Q000378:metabolism; D011487:Protein Conformation; D006180:Proton-Translocating ATPases / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000201:enzymology; D016415:Sequence Alignment; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
chemical_list: D002412:Cations; D007473:Ion Channels; D008565:Membrane Proteins; D006859:Hydrogen; D012964:Sodium; D006180:Proton-Translocating ATPases; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium; D002118:Calcium