Inhibitory effect of prostaglandin oligomeric derivatives on 9,10-dimethyl-1,2-benzanthracene-induced hamster lingual carcinomas.
The inhibitory effects of prostaglandin oligomeric derivatives OC-3186 and OC-5186 were examined in hamster lingual carcinoma induced by 9,10-dimethyl-1,2-benzanthracene (DMBA). These compounds caused a regression of 40-90% in the size of lingual carcinomas in the hamster within several days after systemic or local administration.
Hidaka
S
S
Department of Oral Biochemistry, Fukuoka Dental College, Japan.
Morita
N
N
Ohnishi
S T
ST
Oga
Y
Y
Abe
K
K
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000527:Alprostadil / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D006224:Cricetinae; D008647:Mesocricetus; D011456:Prostaglandins B / Q000494:pharmacology*; D051381:Rats; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D011456:Prostaglandins B; C060276:MR 356; C070097:OC 5186; D015127:9,10-Dimethyl-1,2-benzanthracene; D000527:Alprostadil