Interaction of 5-azacytidine and dexamethasone in the control of hepatic tyrosine aminotransferase.
The nucleoside analog 5-azacytidine is able to induce tyrosine aminotransferase several-fold in the liver of suckling rats. Bilateral adrenalectomy abolishes this inducing effect. The drug also decreases significantly the concentration of cytosolic glucocorticoid receptor accompanied by an increase of the glucocorticoid receptor concentration in the nuclei. The antiglucocorticoid RU 486 which abolishes the induction of tyrosine aminotransferase and serine dehydratase by dexamethasone very effectively is not able to inhibit either the induction of tyrosine aminotransferase or the translocation of the glucocorticoid receptor into the nuclei by 5-azacytidine.
Schulze
A
A
Institute of Biochemistry, University of Leipzig School of Medicine, Germany.
Böhme
H J
HJ
Goltzsch
W
W
Hofmann
E
E
D000818:Animals; D001374:Azacitidine / Q000494:pharmacology*; D003907:Dexamethasone / Q000378:metabolism / Q000494:pharmacology*; D004790:Enzyme Induction; D012695:L-Serine Dehydratase / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D014444:Tyrosine Transaminase / Q000096:biosynthesis*
D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D014444:Tyrosine Transaminase; D012695:L-Serine Dehydratase; D001374:Azacitidine