Adaptive response in irradiated human lymphocytes: radiobiological and genetical aspects.
The adaptive response (AR) in human lymphocytes in different experimental protocols was investigated. The AR was found to be present in cells pre-exposed to 3 cGy of X-rays in G0, G1 and S phase as well as with tritiated water (4 muCi/ml) when the 'challenge' dose was given in G2. There was no AR after prior exposure of the cells in S phase to secondary irradiation from 70 GeV protons. The AR was not observed after preliminary X-irradiation of the lymphocytes in G0 and G1 and 'challenge' irradiation in G1. Cells from 6 patients with Down's syndrome were tested. At least 5 of them did not show the AR. The AR is considered to be a phenomenon of the antimutagenic aftereffect.
Khandogina
E K
EK
2nd Moscow Medical Institute, Academy of Sciences of the U.S.S.R.
Mutovin
G R
GR
Zvereva
S V
SV
Antipov
A V
AV
Zverev
D O
DO
Akifyev
A P
AP
D000222:Adaptation, Physiological; D000328:Adult; D002453:Cell Cycle; D002478:Cells, Cultured; D004314:Down Syndrome / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000378:metabolism / Q000528:radiation effects*; D008297:Male; D011836:Radiation Tolerance