Biochemical and histological findings on the effect of fibronectin in rabbits with experimental corneal disorders.
The effects of purified plasma fibronectin (FN) in corneal disorders were investigated. Histological findings, the levels of ascorbic acid (AA) and glutathione (GSH) in tear fluids were observed sequentially in rabbits with experimental corneal damage and the degree of corneal lesions was observed. The results indicated that healing of the tissue damage was more promoted in the FN group than in the controls and it was suggested that FN promoted the healing of corneal disorders.
Hiraki
S
S
Department of Ophthalmology, School of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Hayami
H
H
Numata
K
K
Kubota
Y
Y
Kobayashi
M
M
Tanaka
S
S
Karges
H E
HE
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000188:drug therapy* / Q000473:pathology; D005353:Fibronectins / Q000627:therapeutic use*; D005978:Glutathione / Q000378:metabolism; D008854:Microscopy, Electron; D011817:Rabbits; D013194:Staining and Labeling; D013666:Tears / Q000378:metabolism
D005353:Fibronectins; D005978:Glutathione; D001205:Ascorbic Acid