title: Beneficial effects of prewarming the donor liver for rat liver transplantation.
abstract: Cold preservation of donor liver can injure the microcirculation enough to impair the function and survival of the transplanted liver. In this study, prewarming the donor liver to 10 degrees C to 12 degrees C after cold storage prior to implantation significantly increased survival rates in rats 1 week after surgery. Following 6, 8, or 9 hours of cold storage in chilled normal saline, prewarming increased survival rates from 40% to 78.6%, from 0% to 35.7%, and from 0% to 14.3%, respectively. The results suggest that pretreatment of the donor liver with warmth following cold storage and before implantation will improve the survival rate of liver transplanted rats.
authors.affiliation: Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
authors.forename: H S
authors.initials: HS
authors.lastname: Xu
authors.forename: D J
authors.initials: DJ
authors.lastname: Wang
authors.forename: R C
authors.initials: RC
authors.lastname: Pace
authors.forename: R S
authors.initials: RS
authors.lastname: Jones
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001646:Bile / Q000378:metabolism; D006358:Hot Temperature; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver; D008102:Liver Circulation / Q000502:physiology; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000401:mortality / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases