Argyrophilic nucleolar organizer region counts and Ki-67 scores in human renal cell carcinoma.
The proliferative activity of 21 cases of renal cell carcinoma has been investigated by means of monoclonal antibody Ki-67 and Nucleolar Organizer Regions (AgNORs) analysis. The correlation between AgNOR counts and Ki-67 scores was only slightly significant (r = 0.53, r2 = 0.28) as determined by linear regression. Positive correlation was found between Ki-67 scores and tumour histologic grade. However, no correlation was observed between Ki-67 scores and tumour pathologic stage and between AgNOR counts and tumour histologic grade and/or pathologic stage. The results suggest that AgNOR counts cannot replace Ki-67 scores in evaluating the proliferative activity of renal cell carcinoma and that such activity and both histologic grade and pathologic stage seem to be independent parametres.
Pich
A
A
Department of Biomedical Sciences and Human Oncology, University of Turin, Italy.
Valente
G
G
Azzoni
L
L
Stramignoni
A
A
Margaria
E
E
Tasso
M
M
D000704:Analysis of Variance; D000911:Antibodies, Monoclonal; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen; D007680:Kidney Neoplasms / Q000473:pathology*; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D009697:Nucleolus Organizer Region / Q000473:pathology*; D012044:Regression Analysis; D012834:Silver; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D012834:Silver