title: Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase.
authors.affiliation: Department of Biochemistry, Michigan State University, East Lansing 48824.
authors.forename: W L
authors.initials: WL
authors.lastname: Smith
authors.forename: T E
authors.initials: TE
authors.lastname: Eling
authors.forename: R J
authors.initials: RJ
authors.lastname: Kulmacz
authors.forename: L J
authors.initials: LJ
authors.lastname: Marnett
authors.forename: A
authors.initials: A
authors.lastname: Tsai
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005609:Free Radicals; D006418:Heme / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*
chemical_list: D016861:Cyclooxygenase Inhibitors; D005609:Free Radicals; D014443:Tyrosine; D006418:Heme; D006861:Hydrogen Peroxide; D011451:Prostaglandin-Endoperoxide Synthases