Immunohistochemical studies of chromogranins (A and C) in pituitary adenomas.
Expression of Chromogranin A and C was examined immunohistochemically on 45 surgically obtained pituitary adenomas. Positive rate of chromogranin A was 40.0% and chromogranin C was positive in 8.0% of 45 pituitary adenomas. Chromogranin A was expressed frequently in adenomas in which at least one of the FSH alpha, FSH beta, LH beta and TSH beta subunits was positive. It also expressed frequently in non-functioning adenomas. The positive rate of chromogranin A was low in GH or PRL positive adenomas. These findings suggest that chromogranin could be a parameter of the functional differentiation of the pituitary adenomas.
Oda
K
K
Department of Pathology, Tokai University, School of Medicine, Kanagawa, Japan.
Inada
K
K
Osamura
R Y
RY
D000236:Adenoma / Q000378:metabolism* / Q000503:physiopathology; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism*; D006062:Gonadotropins / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D011388:Prolactin / Q000378:metabolism; D011506:Proteins; D013194:Staining and Labeling; D013972:Thyrotropin / Q000378:metabolism
D053379:Chromogranin A; D002864:Chromogranins; D006062:Gonadotropins; D011506:Proteins; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone