Chemotherapy for advanced testicular cancer.
Testis cancer has become one of the most curable of all solid malignancies. More than 95% of patients should be cured with appropriate treatment and should have few long-term treatment-related side effects. Current chemotherapy for advanced testis cancer has resulted from an orderly sequence of chemotherapy trials that serves as a model for cancer chemotherapy development. Recent studies have defined the least therapy required to minimize toxicity while maintaining a high cure rate in "low-risk" patients. Further improvements are necessary in "high-risk" patients; evaluation of new regimens by means of randomized trials is essential.
Fox
E P
EP
Department of Medicine, Indiana University School of Medicine, Indianapolis.
Loehrer
P J
PJ
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004407:Dysgerminoma / Q000188:drug therapy / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D009919:Orchiectomy; D011379:Prognosis; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D011928:Raynaud Disease / Q000139:chemically induced / Q000453:epidemiology; D012306:Risk; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery
D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin