[The daily dynamics of blood lipids in elderly subjects with hypertension].
Three groups of elderly subjects were examined: patients with sclerotic systolic hypertension (SSH), with essential hypertension (EH), and normal subjects. The blood levels of total lipids, cholesterol, triglycerides, low and very low density lipoproteins, phospholipids, and nonesterified fatty acids were significantly higher in the patients than in normal subjects. In contrast to those in normal subjects, acrophases of atherogenic lipid fractions (cholesterol, triglycerides, low and very low density lipoproteins) in the patients were synchronized and occurred in the day time (at 2-4 p.m.). Diverse directions of circadian changes in lipid fractions in the patients and normal subjects may contribute to alteration in the rhythmicity of other metabolisms and in the blood coagulation system, thus leading to various complications. This fact necessitates development of methodologic approaches to chronotherapy of the afore-said disorders. To detect latent atherogenic shifts in the lipid transport system in elderly patients with SSH and EH, studies of lipid metabolism parameters are recommended to be carried out between 2 and 4 o'clock p.m.
Khamidov
N Kh
NKh
Zaslavskaia
R M
RM
Arustamian
G S
GS
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008055:Lipids
Sutochnaia dinamika lipidov krovi pri gipertonicheskoĭ bolezni u lits starshikh vozrastov.