title: A 90-kDa surface antigen of immature smooth muscle cells is ICAM-1.
abstract: A monoclonal antibody, designated 10F3, that reacts with an antigen of molecular mass 90,000 Da has been developed by immunization of BALB/c mice with smooth muscle cells in long-term culture. The cells were originally isolated from fetal human aorta. The 10F3 was identified as an antibody that reacts with the ICAM-1 molecule. ICAM-1 is a mesenchymal antigen that is lost during differentiation of cells other than endothelium but is reexpressed by the intimal cells of vessels involved in atherogenesis.
authors.affiliation: Institute of Experimental Cardiology, Moscow, USSR.
authors.lastname: Printseva OYu
authors.forename: M M
authors.initials: MM
authors.lastname: Peclo
authors.forename: A V
authors.initials: AV
authors.lastname: Tjurmin
authors.forename: A M
authors.initials: AM
authors.lastname: Gown
mesh_terms: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis* / Q000737:chemistry; D001011:Aorta / Q000737:chemistry / Q000196:embryology; D001161:Arteriosclerosis / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000032:analysis*; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D018799:Intercellular Adhesion Molecule-1; D008970:Molecular Weight; D009131:Muscle, Smooth, Vascular / Q000737:chemistry* / Q000166:cytology / Q000196:embryology; D015531:Radioimmunoprecipitation Assay; D013194:Staining and Labeling
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1