title: [Pathology and immunohistochemical demonstration of beta-HCG in intracranial primary germinoma].
abstract: Clinical pathologic observation and immunohistochemical demonstration on beta--HCG are reported in 13 cases of intracranial primary germinomas, including 7 cases of germinomas in the region of the pineal gland and 6 cases in the hypothalamic area. Among them, there were 11 cases of simple type and 2 cases of beta--HCG--producing tumors with a character of differentiation of trophoblasts in the latter. This paper supports the concept that intracranial primary germinoma is an atypical teratoma arising from the germ cells. The significance of beta--HCG immunohistochemical demonstration in the pathologic diagnosis of germinomas and the mechanism of endocrine disturbance are discussed.
authors.affiliation: Beijing Xuan--Wu Hospital.
authors.forename: Q Z
authors.initials: QZ
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D002648:Child; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004407:Dysgerminoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism*; D010871:Pinealoma / Q000378:metabolism / Q000473:pathology*
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments