Cardiac myxomas: immunohistochemical study of benign and malignant variants.
Immunohistochemical investigation of 11 cardiac myxomas (CMs) including one malignant metastasizing CM showed a co-expression of epithelial (lu-5 and CAM 5.2), mesenchymal (vimentin) and neuroendocrine antigens (neuron-specific enolase) in all tumour cells. Factor VIII was found in the endothelial cells of capillaries only. In the subendocardium of fetal heart tissue close to the foramen ovale myofibroblasts reacting with the panepithelial antibody lu-5 were detected. We conclude that CMs are neoplasms that may develop from embryonic cell remnants.
Curschellas
E
E
Institute of Pathology, Kantonsspital, University of Basel, Switzerland.
Toia
D
D
Borner
M
M
Mihatsch
M J
MJ
Gudat
F
F
D000328:Adult; D000368:Aged; D004699:Endocardium / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006338:Heart Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000378:metabolism* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D014746:Vimentin; D007633:Keratins; D005169:Factor VIII; D010751:Phosphopyruvate Hydratase