31P spectroscopy of the human prostate gland in vivo using a transrectal probe.
Using a transrectal probe, good quality 31P magnetic resonance spectroscopy of the human prostate was performed safely, consistently, and in a reasonable amount of time (average of 60 min). Initial results indicate that transrectal 31P MRS has the ability to characterize the phosphorylated metabolites of normal, hyperplastic, and malignant prostates. This study demonstrated that malignant prostates are characterized by significantly decreased levels of phosphocreatine (PCr) and increased levels of phosphomonoesters (PME) as compared to healthy prostates.
Kurhanewicz
J
J
Department of Urology, University of California School of Medicine, San Francisco 94143-0738.
Thomas
A
A
Jajodia
P
P
Weiner
M W
MW
James
T L
TL
Vigneron
D B
DB
Narayan
P
P
D000328:Adult; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*