Prospects for the use of synthetic antigens in immunodiagnosis.
Methods for the localization and prediction of protein antigenic determinants are described, and the diagnostic potential of synthetic peptide antigens in cases of HIV, hepatitis B, and influenza is demonstrated. Attention is concentrated on the principles governing the creation and application of artificial diagnostic preparations.
Khaitov
R M
RM
Institute of Immunology, Ministry of Health of the USSR, Moscow.
Andreev
S M
SM
D000595:Amino Acid Sequence; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000235:genetics / Q000276:immunology; D015700:HIV Envelope Protein gp41 / Q000235:genetics / Q000276:immunology; D015658:HIV Infections / Q000175:diagnosis* / Q000276:immunology; D006388:Hemagglutinins / Q000276:immunology; D006509:Hepatitis B / Q000175:diagnosis* / Q000276:immunology; D006511:Hepatitis B Antigens / Q000276:immunology; D006801:Humans; D007251:Influenza, Human / Q000175:diagnosis* / Q000276:immunology; D008969:Molecular Sequence Data; D014614:Vaccines, Synthetic
D000939:Epitopes; D015699:HIV Envelope Protein gp120; D015700:HIV Envelope Protein gp41; D006388:Hemagglutinins; D006511:Hepatitis B Antigens; D014614:Vaccines, Synthetic