title: Neutralization epitope in the envelope glycoprotein of simian retrovirus-1 (SRV-1) and identification of the virus receptor.
abstract: We previously demonstrated that the area encompassing residues 147-162 of the envelope protein of simian retrovirus serotype-1 (SRV-1) is the target for rhesus anti-SRV-1 neutralizing antibodies. A peptide representing amino acids 142-167 of envelope protein (gp70) is capable of inducing virus-neutralizing antibodies in mice. The virus receptor was immunoprecipitated from Raji cells using gp70 as the ligand. Antibodies to peptide 142-167 inhibit the immunoprecipitation, indicating that the receptor recognizes residues 142-167 of the viral envelope protein.
authors.affiliation: Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis 95616.
authors.forename: J V
authors.initials: JV
authors.lastname: Torres
authors.forename: L L
authors.initials: LL
authors.lastname: Werner
authors.forename: A
authors.initials: A
authors.lastname: Malley
authors.forename: E
authors.initials: E
authors.lastname: Benjamin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology*; D002460:Cell Line; D000939:Epitopes / Q000032:analysis* / Q000737:chemistry; D015686:Gene Products, env / Q000737:chemistry / Q000276:immunology*; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D015531:Radioimmunoprecipitation Assay; D011991:Receptors, Virus / Q000032:analysis*; D015301:Retroviruses, Simian / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D015686:Gene Products, env; D011991:Receptors, Virus