Immune enhancement of a polysaccharides peptides isolated from Coriolus versicolor.
A protein-bound polysaccharides (PSP) isolated from Coriolus versicolor in Shanghai, at the concentrations of 100-800 micrograms/ml promoted lymphocyte proliferation. PSP 25 mg/kg ip into mice for 5 d antagonized the inhibition of IL-2 production by cyclophosphamide from activated T lymphocytes and restored the suppressed T-cell-mediated delayed, type hypersensitivity response to normal. PSP 10-1000 micrograms/ml induced interferon alpha and gamma production from human peripheral leukocytes 4 and 8 times respectively higher than that of the control groups. Moreover, PSP also increased phagocytic functions of host reticulo-endothelial system. The results suggest that the anti-tumor effects of PSP may be related to its potentiation of host immunological responses.
Li
X Y
XY
Shanghai Institute of Materia Medica, Chinese Academy of Sciences.
Wang
J F
JF
Zhu
P P
PP
Liu
L
L
Ge
J B
JB
Yang
S X
SX
D000818:Animals; D005260:Female; D005658:Fungi; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007155:Immunologic Factors / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D011134:Polysaccharides / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology
D007155:Immunologic Factors; D007376:Interleukin-2; D011134:Polysaccharides; D007372:Interferons