title: [The aldehyde dehydrogenase activity in the erythrocytes of alcoholic patients].
abstract: Red cell aldehyde dehydrogenase (ALDH, EC 1.2.1.3) activity was measured by spectrophotometry in normal subjects and alcoholics after various periods of alcohol abstinence. ALDH was measured in all red cell hemolysate fractions; red cells were purified from hemoglobin by Sephadex CM-50 chromatography. The enzyme activity was found reduced in alcoholics' red cells as against that in controls. ALDH activities were somewhat increasing and approaching the normal values in the patients not using ethanol for 4 weeks or longer. These results recommend ALDH measurements in human red cells as a test for the detection of subjects abusing alcohol.
authors.forename: I M
authors.initials: IM
authors.lastname: Matveeva
authors.forename: M A
authors.initials: MA
authors.lastname: Petrova
authors.forename: M S
authors.initials: MS
authors.lastname: Usatenko
authors.forename: N E
authors.initials: NE
authors.lastname: Sokolovskaia
authors.forename: T G
authors.initials: TG
authors.lastname: Rybakova
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Borodkin
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000201:enzymology*; D000444:Aldehyde Dehydrogenase / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000444:Aldehyde Dehydrogenase
vernacular_title: Aktivnost' al'degiddegidrogenazy v éritrotsitakh bol'nykh alkogolizmom.