The shiverer mouse mutation shi/shi: rescue and preimplantation detection.
The shiverer mouse mutation has been used as a model in this series of experiments. Germ-line therapy of this disorder has been demonstrated by producing mice transgenic for the wild-type gene for myelin basic protein (MBP). The mutation has also been diagnosed in preimplantation mouse blastocysts.
Readhead
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Division of Biology, California Institute of Technology, Pasadena 91125.
Muggleton-Harris
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D000818:Animals; D001755:Blastocyst / Q000473:pathology; D005260:Female; D015316:Genetic Therapy; D051379:Mice; D008818:Mice, Neurologic Mutants; D008822:Mice, Transgenic; D004676:Myelin Basic Protein / Q000235:genetics; D009900:Optic Nerve / Q000648:ultrastructure; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D014202:Tremor / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*
D004676:Myelin Basic Protein