title: Change of external urethral sphincter function in prostatic patients.
abstract: External urethral function was urodynamically examined in 13 patients with benign prostatic hypertrophy (BPH) associated with chronic urinary retention and in 5 volunteers. Prevoiding drop in external urethral sphincter pressure was noted in all the volunteers, whereas it was not found in 6 of the 13 cases of BPH. Bladder neck opening pressure was higher in these 6 cases (p less than 0.05). After administration of phentolamine, prevoiding drop was noted in 5 of these 6 cases, and bladder neck opening pressure decreased so much that there was no significant intergroup difference. The above results mean that the increase in alpha-adrenergic receptors makes the prostate, which has been already hypertrophied, less elastic, inhibiting external urinary sphincter function.
authors.affiliation: Department of Urology, School of Medicine, Chiba University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yasuda
authors.forename: K
authors.initials: K
authors.lastname: Nagashima
authors.forename: N
authors.initials: N
authors.lastname: Murayama
authors.forename: T
authors.initials: T
authors.lastname: Yamanishi
authors.forename: M
authors.initials: M
authors.lastname: Tojo
authors.forename: J
authors.initials: J
authors.lastname: Shimazaki
mesh_terms: D000368:Aged; D006801:Humans; D008297:Male; D011312:Pressure; D011467:Prostate / Q000294:innervation; D011470:Prostatic Hyperplasia / Q000150:complications / Q000503:physiopathology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D014521:Urethra / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology; D016055:Urinary Retention / Q000209:etiology / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology
chemical_list: D011942:Receptors, Adrenergic, alpha