The effect of filtered-coffee consumption on plasma lipid levels. Results of a randomized clinical trial.
OBJECTIVE
--To determine the effect of filtered-coffee consumption on plasma lipoprotein cholesterol levels in healthy men.


METHODS
--Randomized controlled trial with an 8-week washout period followed by an 8-week intervention period during which men were randomly assigned to drink 720 mL/d of caffeinated coffee, 360 mL/d of caffeinated coffee, 720 mL/d of decaffeinated coffee, or no coffee.


METHODS
--Outpatient clinical research center in a university medical center.


METHODS
--One hundred healthy male volunteers.


METHODS
--Changes in plasma lipoprotein cholesterol levels during the intervention period.


RESULTS
--Men who consumed 720 mL of caffeinated coffee daily had mean increases in plasma levels of total cholesterol (0.24 mmol/L, P = .001), low-density lipoprotein cholesterol (0.17 mmol/L, P = .04), and high-density lipoprotein cholesterol (0.08 mmol/L, P = .03). No significant changes in these plasma lipoprotein levels occurred in the other groups. Compared with the group who drank no coffee the group who drank 720 mL/d of caffeinated coffee had increases in plasma levels of total cholesterol (0.25 mmol/L, P = .02), low-density lipoprotein cholesterol (0.15 mmol/L, P = .17), and high-density lipoprotein cholesterol (0.09 mmol/L, P = .12) after adjustment for changes in diet.


CONCLUSIONS
--Consumption of 720 mL/d of filtered, caffeinated coffee leads to a statistically significant increase in the plasma level of total cholesterol, which appears to be due to increases of both low-density lipoprotein and high-density lipoprotein cholesterol levels.
Fried
R E
RE
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md.
Levine
D M
DM
Kwiterovich
P O
PO
Diamond
E L
EL
Wilder
L B
LB
Moy
T F
TF
Pearson
T A
TA
D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003069:Coffee; D005374:Filtration; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003069:Coffee; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol