HIV, HBV and HCV seropositivity in hemophiliacs.
Eleven cases of severe type hemophiliacs who had received long-term factor VIII injections were tested for the serological markers of human immunodeficiency virus (HIV), hepatitis B virus and hepatitis C virus (HCV). The period of factor VIII concentrate injections ranged from 2 to 32 years. The seropositive rates of HIV and HCV were 9/11(82%) and 11/11(100%), respectively. The seropositive rate of hepatitis B surface antigen was only 1/11(9%), while the seropositive rates of antibody to hepatitis B core antigen and antibody to hepatitis B surface antigen were 9/11(82%) and 7/11(64%), respectively, Although the patients had no symptoms related to acquired immunodeficiency syndrome, they were noted to have inverted helper/suppressor T-lymphocyte ratio, suggesting that hemophiliacs with long-term factor VIII injections have a high incidence of HIV and HCV infection, with immunological aberration.
Chow
M P
MP
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Lin
C K
CK
Lin
J S
JS
Chau
W K
WK
Ho
C H
CH
Chen
S Y
SY
Lee
S H
SH
Yung
C H
CH
D000328:Adult; D005169:Factor VIII / Q000627:therapeutic use; D015658:HIV Infections / Q000209:etiology*; D006679:HIV Seropositivity; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000209:etiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000209:etiology*; D018937:Hepatitis C Antibodies; D006801:Humans; D008297:Male; D008875:Middle Aged
D006508:Hepatitis Antibodies; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D005169:Factor VIII