Epitopes of cartilage core proteins and GAG pattern in human non-Hodgkin lymphoma xenografts.
Glycosaminoglycan and core protein components of proteoglycans (PGs) have been studied in three human non-Hodgkin lymphoma xenografts of B cell origin. Lymphomas showed similar GAG content, but different composition of GAG subtypes. This variability was accompanied by an individual capacity to adhere to extracellular matrix elements. The core proteins identified by monoclonal antibodies raised against human cartilage chondroitin sulfate PG were also distinctly expressed and released. These proteins shared by different cell types may have biological significance.
Kopper
L
L
Ist Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Budapest, Hungary.
Timar
J
J
Kovalszky
I
I
Fulop
C
C
Glant
T
T
D053674:Aggrecans; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins / Q000032:analysis* / Q000276:immunology; D006025:Glycosaminoglycans / Q000032:analysis* / Q000145:classification / Q000276:immunology; D037181:Lectins, C-Type; D016393:Lymphoma, B-Cell / Q000737:chemistry* / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology; D009368:Neoplasm Transplantation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000737:chemistry* / Q000276:immunology; D011509:Proteoglycans / Q000032:analysis* / Q000276:immunology; D014183:Transplantation, Heterologous
C508320:Acan protein, mouse; D053674:Aggrecans; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000939:Epitopes; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D006025:Glycosaminoglycans; D037181:Lectins, C-Type; D009363:Neoplasm Proteins; D011509:Proteoglycans