[Production of leukocyte-poor thrombocyte concentrates: results with a new kind of filter system].
A newly developed filter-system (Sepacell PL) for the removal of leukocytes from single donor platelet concentrates was tested. It removes contaminating leukocytes by 99.9%, the platelet loss was calculated as less than 1%. Platelet ultrastructure and function do not seem to be altered by the filtration. Therefore, the tested filter system seems to be a suitable device for leukocyte depletion of single donor platelet concentrates. Further clinical studies, however, are necessary to prove the efficiency of the filter system in preventing alloimmunization in vivo.
Böck
M
M
Transfusionszentrum (Med. Klinik III), Klinikum Grosshadern, Universität München.
Salat
C
C
Greither
L
L
Heim
M U
MU
Weindler
R
R
Bilas
A
A
Mempel
W
W
D001803:Blood Transfusion / Q000295:instrumentation*; D002469:Cell Separation / Q000295:instrumentation*; D006801:Humans; D007958:Leukocyte Count; D010974:Platelet Aggregation / Q000502:physiology; D010976:Platelet Count; D017713:Platelet Transfusion; D010983:Plateletpheresis / Q000295:instrumentation*
Herstellung leukozytenarmer Thrombozytenkonzentrate: Ergebnisse mit einem neuartigen Filtersystem.