Hypothalamic 5-hydroxytryptamine metabolism is not influenced by streptozotocin-diabetes induced at neonatal age.
Rats were rendered diabetic at neonatal age by an intraperitoneal injection of streptozotocin (90 mg/kg). At 8-10 weeks of age, their 5-HT and 5-HIAA levels in different hypothalamic nuclei (ventromedial, paraventricular, periventricular, supraoptical and suprachiasmatic nuclei) were similar to control animals which received vehicle only. It is concluded that the combination of mild hyperglycemia and hypoinsulinemia does not affect hypothalamic 5-HT metabolism in rats.
Huupponen
R
R
Department of Pharmacology, University of Turku, Finland.
Koulu
M
M
Pesonen
U
U
D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid