title: Management of a severe transfusional problem in a patient with alloantibody to Kpb (K4).
abstract: The case of a 58-year-old male with severe anemia after hemicolectomy is described. The patient proved to be Kp(b-), and the serum contained anti-Kpb. Because no Kp(b-) donors were available, two incompatible units are administered after intravenous gammaglobulin (400 mg/kg/day) and hydrocortisone (500 mg). The tolerance was good, without signs of increased red cell destruction. Pending the arrival of compatible blood from the American Red Cross, the hematocrit reached 18%, and the direct antiglobulin test remained negative.
authors.affiliation: Departamento de Hemoterapia e Inmunohematología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.
authors.forename: A I
authors.initials: AI
authors.lastname: Kohan
authors.forename: J F
authors.initials: JF
authors.lastname: Reybaud
authors.forename: H J
authors.initials: HJ
authors.lastname: Salamone
authors.forename: J A
authors.initials: JA
authors.lastname: Rey
authors.forename: C E
authors.initials: CE
authors.lastname: Rey
authors.forename: N
authors.initials: N
authors.lastname: Villaravid
authors.forename: S
authors.initials: S
authors.lastname: Papa
authors.forename: S
authors.initials: S
authors.lastname: Cyrulik Goldztein
authors.forename: R
authors.initials: R
authors.lastname: Calahonra
authors.forename: J C
authors.initials: JC
authors.lastname: Sanchez Avalos
mesh_terms: D001787:Blood Group Incompatibility / Q000517:prevention & control*; D001803:Blood Transfusion / Q000379:methods*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007518:Isoantibodies / Q000302:isolation & purification*; D007626:Kell Blood-Group System / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D007518:Isoantibodies; D007626:Kell Blood-Group System; D005719:gamma-Globulins; D006854:Hydrocortisone