A 90-kDa surface antigen of immature smooth muscle cells is ICAM-1.
A monoclonal antibody, designated 10F3, that reacts with an antigen of molecular mass 90,000 Da has been developed by immunization of BALB/c mice with smooth muscle cells in long-term culture. The cells were originally isolated from fetal human aorta. The 10F3 was identified as an antibody that reacts with the ICAM-1 molecule. ICAM-1 is a mesenchymal antigen that is lost during differentiation of cells other than endothelium but is reexpressed by the intimal cells of vessels involved in atherogenesis.
Printseva OYu
Institute of Experimental Cardiology, Moscow, USSR.
Peclo
M M
MM
Tjurmin
A V
AV
Gown
A M
AM
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis* / Q000737:chemistry; D001011:Aorta / Q000737:chemistry / Q000196:embryology; D001161:Arteriosclerosis / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000032:analysis*; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D018799:Intercellular Adhesion Molecule-1; D008970:Molecular Weight; D009131:Muscle, Smooth, Vascular / Q000737:chemistry* / Q000166:cytology / Q000196:embryology; D015531:Radioimmunoprecipitation Assay; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D018799:Intercellular Adhesion Molecule-1