Dietary fluoride, unlike bromide or iodide, counteracts phosphorus-induced nephrocalcinosis in female rats.
Supplemental dietary F has been shown to counteract P-induced nephrocalcinosis in female rats. In order to obtain information as to the specificity of this F effect, the effect of other halogens, namely Br and I, on P-induced nephrocalcinosis was studied in weanling female rats. Supplemental dietary Br (5.24 mmol/kg of diet) and I (1.43 mmol/kg of diet) did not influence P-induced nephrocalcinosis, whereas F at equimolar dietary concentrations had marked antinephrocalcinogenic activity. The halogens were added to the diets in the form of KBr, KI, and NaF; the diets were balanced for the kations with Cl salts. The addition of KI to the diet to a concentration of 5.24 mmol/kg caused pronounced growth retardation, decreased feed intake, hepatomegaly, and signs of lethargy. It is concluded that the protective effect of dietary F against P-induced nephrocalcinosis does not extend to other halogens.
Fransbergen
A J
AJ
Department of Laboratory Animal Science, State University, Utrecht, The Netherlands.
Lemmens
A G
AG
Beynen
A C
AC
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001965:Bromides / Q000494:pharmacology* / Q000652:urine; D004435:Eating; D005260:Female; D005459:Fluorides / Q000494:pharmacology* / Q000652:urine; D005527:Food, Fortified; D007454:Iodides / Q000494:pharmacology* / Q000652:urine; D009397:Nephrocalcinosis / Q000139:chemically induced / Q000188:drug therapy*; D010758:Phosphorus; D051381:Rats; D011919:Rats, Inbred Strains
D001965:Bromides; D007454:Iodides; D010758:Phosphorus; D005459:Fluorides