Morphological study of the capsular organization around tissue expanders coated with N-carboxybutyl chitosan.
Expanders coated with N-carboxybutyl chitosan were inserted into surgical wounds in the dorsal skin of rabbits and the formation of capsular tissue was studied by scanning electron microscopy and transmission electron microscopy. N-carboxybutyl chitosan, in the course of the capsular organization, favours and potentiates the correct proliferation and organization of the tissue, rather than sustaining reactive processes leading to scar formation. N-carboxybutyl chitosan stimulates physiologically the tissue repair process and favours angiogenesis, whilst depressing fibrogenesis to a certain extent. Applications are envisaged in the treatment of wounds and in plastic surgery.
Biagini
G
G
Facoltà di Medicina e Chirurgia, Università di Ancona, Italy.
Pugnaloni
A
A
Damadei
A
A
Bertani
A
A
Belligolli
A
A
Bicchiega
V
V
Muzzarelli
R
R
D000818:Animals; D001672:Biocompatible Materials; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D003094:Collagen / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D005347:Fibroblasts / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D009389:Neovascularization, Pathologic; D015388:Organelles / Q000648:ultrastructure; D011817:Rabbits; D012867:Skin / Q000098:blood supply; D015625:Tissue Expansion Devices
D001672:Biocompatible Materials; C067347:N-carboxybutyl chitosan; D002686:Chitin; D003094:Collagen; D048271:Chitosan