title: Synthesis and biochemical studies of dithioate DNA.
abstract: Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in HeLa cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309-0215.
authors.forename: M H
authors.initials: MH
authors.lastname: Caruthers
authors.forename: G
authors.initials: G
authors.lastname: Beaton
authors.forename: L
authors.initials: L
authors.lastname: Cummins
authors.forename: D
authors.initials: D
authors.lastname: Graff
authors.forename: Y X
authors.initials: YX
authors.lastname: Ma
authors.forename: W S
authors.initials: WS
authors.lastname: Marshall
authors.forename: H
authors.initials: H
authors.lastname: Sasmor
authors.forename: P
authors.initials: P
authors.lastname: Norris
authors.forename: E K
authors.initials: EK
authors.lastname: Yau
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D006678:HIV / Q000201:enzymology; D008969:Molecular Sequence Data; D018894:Reverse Transcriptase Inhibitors; D016914:Ribonuclease H / Q000378:metabolism; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D018894:Reverse Transcriptase Inhibitors; D013873:Thionucleotides; D004247:DNA; D016914:Ribonuclease H