Anti-adhesive molecules of the extracellular matrix.
The prototype extracellular matrix glycoproteins had been identified on the basis of their activity in promoting cell adhesion and spreading. Recently, more and more evidence is accumulating that the reverse effect of extracellular matrix proteins, namely the inhibition of cell adhesion and spreading, may be equally important for proper cell function during morphogenesis and development. Several anti-adhesive proteins have been described and their mechanisms of action are being investigated.
Chiquet-Ehrismann
R
R
Friedrich Miescher Institute, Basel, Switzerland.
D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D015676:Osteonectin / Q000502:physiology*; D019063:Tenascin
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D015676:Osteonectin; D019063:Tenascin