Acute reduction and long-term improvement of chorea with ceruletide (cholecystokinin analogue).
We studied the effects of ceruletide, a cholecystokinin analogue, on choreic involuntary movement in several neurological diseases by clinical scoring and electromyography in 11 patients. Ceruletide brought about a brief reduction of choreic movement reaching its maximum within 60 min and another long-lasting improvement over several weeks by single administration. The levels of homovanillic acid in cerebrospinal fluid before treatment were significantly higher in cases with long-lasting improvement than those in cases without improvement. We suggest that ceruletide may reduce choreic movement for a long period through effects on the central dopamine system and speculate that such a long-term effect may be accounted for by the change in transmission after the second messengers in neurons.
Hashimoto
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T
Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.
Yanagisawa
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N
D000328:Adult; D000368:Aged; D002108:Ceruletide / Q000494:pharmacology / Q000627:therapeutic use*; D002766:Cholecystokinin / Q000502:physiology; D002819:Chorea / Q000134:cerebrospinal fluid / Q000188:drug therapy*; D004298:Dopamine / Q000378:metabolism; D004341:Drug Evaluation; D004576:Electromyography; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009435:Synaptic Transmission / Q000187:drug effects
D006897:Hydroxyindoleacetic Acid; D002108:Ceruletide; D002766:Cholecystokinin; D004298:Dopamine; D006719:Homovanillic Acid