title: HLA-A29.2 subtype associated with birdshot retinochoroidopathy.
abstract: Birdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be divided into two subtypes, A29.1 and A29.2, using an immunoprecipitation method succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58 subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the results showed that HLA-A29.2 subtype was present in all patients (100%). We concluded that the absence of HLA-A29.1 subtype is statistically significant (P less than .01) in this study of HLA-A29 subtyping.
authors.affiliation: Department of Ophthalmology, Pitié-Salpêtrière Hospital, University of Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: LeHoang
authors.forename: N
authors.initials: N
authors.lastname: Ozdemir
authors.forename: A
authors.initials: A
authors.lastname: Benhamou
authors.forename: T
authors.initials: T
authors.lastname: Tabary
authors.forename: C
authors.initials: C
authors.lastname: Edelson
authors.forename: H
authors.initials: H
authors.lastname: Betuel
authors.forename: R
authors.initials: R
authors.lastname: Semiglia
authors.forename: J H
authors.initials: JH
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002825:Chorioretinitis / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008040:Genetic Linkage / Q000276:immunology; D015234:HLA-A Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D015234:HLA-A Antigens; C035524:HLA-A29 antigen