title: Serum SP1, hPL and beta-hCG levels in trophoblastic diseases.
abstract: Serum SP1 (pregnancy specific beta 1 glycoprotein), hPL (human placental lactogen) and beta-hCG (beta-human chorionic gonadotropin) in patients with choriocarcinoma, invasive mole, and hydati-diform mole were determined by radioimmunoassay (RIA), and compared with those in normal males, non-pregnant women and normal pregnant women in order to evaluate the clinical significance of SP1, hPL and beta-hCG determinations. Serum SP1 levels at the time of admission were highest in hydatidiform mole (5.1 +/- 0.6 micrograms/L) and lowest in choriocarcinoma (0.5 +/- 0.3 micrograms/L). Serum hPL levels were 68.2 +/- 9.7 ng/L in hydatidiform mole and 26.4 +/- 8.3 ng/L in choriocarcinoma. Serum SP1 and hPL levels in trophoblastic diseases were lower than in normal pregnancies (SP1 11.5 +/- 5.1 micrograms/L, hPL 216.8 +/- 48.1 ng/L). SP1/beta-hCG ratios were less than 1.5 in 4/43 (9.3%) cases of hydatidiform mole and 17/19 (89.5%) cases of invasive mole and choriocarcinoma. The beta-hCG/hPL ratios were below 15 in 35/43 (81.4%) cases of hydatidiform mole and 4/19 (21.1%) malignant trophoblastic diseases. The prognosis after operation and chemotherapy was favourable if patient's SP1 and beta-hCG levels gradually decreased.
authors.affiliation: Department of Obstetrics and Gynecology, Second Teaching Hospital, Bethune University of Medical Sciences, Changchun.
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhang
authors.forename: G L
authors.initials: GL
authors.lastname: Yen
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D002822:Choriocarcinoma / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood*; D002820:Hydatidiform Mole, Invasive / Q000097:blood; D010446:Peptide Fragments / Q000097:blood*; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D011379:Prognosis; D014594:Uterine Neoplasms / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen