title: Time course of pressure and flow in ascending aorta during ejection.
abstract: To analyze aortic flow and pressure relationships, 10 closed-chest anaesthetised dogs were instrumented with electromagnetic aortic flow probes and micromanometers in the left ventricle and ascending aorta. Left ventricular ejection time was divided into: time to peak flow (T1) (both pressure and flow rising), peak flow to peak pressure time (T2) (pressure rising, flow decreasing), and peak pressure to dicrotic notch time (T3) (pressure and flow both decreasing). These time intervals were expressed as percent of total ejection time. Load-active interventions rose markedly T2 (from 4.2 +/- 5.5 to 19.4 +/- 3.5 after phenylephrine (p less than 0.02); from 4.2 +/- 6.5 to 21.2 +/- 5.3 after dextran (p less than 0.02)). Conversely, dobutamine reduced T2 from 4.4 +/- 5.9 to -2.5 +/- 6.5 (p less than 0.05). Thus, during load-active interventions aortic pressure increases for a longer T2 time although forward flow is decreasing, as a result of higher aortic elastic recoil during ejection. Conversely, beta 1-adrenergic stimulation significantly shortens T2. Dynamic pressure-flow relationship is thus continuously changing during ejection. T2 seems to be inversely related to the efficiency of left ventricular ejection dynamics.
authors.affiliation: Department of Internal Medicine, University of Pavia, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Perlini
authors.forename: P L
authors.initials: PL
authors.lastname: Soldà
authors.forename: M
authors.initials: M
authors.lastname: Piepoli
authors.forename: A
authors.initials: A
authors.lastname: Calciati
authors.forename: M
authors.initials: M
authors.lastname: Paro
authors.forename: G
authors.initials: G
authors.lastname: Marchetti
authors.forename: F
authors.initials: F
authors.lastname: Meno
authors.forename: G
authors.initials: G
authors.lastname: Finardi
authors.forename: L
authors.initials: L
authors.lastname: Bernardi
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology*; D003911:Dextrans; D004280:Dobutamine; D004285:Dogs; D005260:Female; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010656:Phenylephrine; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D003911:Dextrans; D010656:Phenylephrine; D004280:Dobutamine