title: Sensitivity of Shigella flexneri and Escherichia coli bacteria to bacteriophages and to colicins, lost or established by the acquisition of R plasmids.
abstract: Lac+ recombinant of Shigella flexneri 2a carrying R-factors of the standard set have been constructed. The R+ transconjugants obtained have been compared with the original strain with respect to their susceptibility to a set of bacteriophages recommended for phagetyping of Shigella strains and to a set of colicins. It have been found that as a result of acquiring some R-factors the susceptibility to bacteriophages changes; presence of certain R-factors causes susceptibility, that of other R-factors--resistance. Similar changes have been observed in the case of susceptibility to colicins. Propable mechanisms of the changes of susceptibility to these factors are discussed.
authors.affiliation: Department of Biology, Medical Faculty, J.E. Purkyne University, Brno, Czechoslovakia.
authors.forename: J
authors.initials: J
authors.lastname: Smarda
authors.forename: W
authors.initials: W
authors.lastname: Doroszkiewicz
authors.forename: T M
authors.initials: TM
authors.lastname: Lachowicz
mesh_terms: D001435:Bacteriophages / Q000502:physiology*; D003087:Colicins / Q000494:pharmacology*; D003090:Coliphages / Q000502:physiology; D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics* / Q000502:physiology; D011815:R Factors / Q000502:physiology*; D011995:Recombination, Genetic; D012763:Shigella flexneri / Q000235:genetics* / Q000502:physiology
chemical_list: D003087:Colicins