title: [Evolution of regulatory proteins].
abstract: A concept of the evolution of signal molecules and their receptors is proposed. The formation of novel regulatory proteins by way of gene fusion and gene shuffling and the role of these processes in metabolic integration are considered. The different receptor variants may be due to alternative splicing which is regulated in a tissue-specific manner.
authors.forename: R M
authors.initials: RM
authors.lastname: Medzhitov
mesh_terms: D005075:Biological Evolution; D004247:DNA / Q000235:genetics; D021382:Protein Sorting Signals / Q000378:metabolism / Q000502:physiology; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D012313:RNA / Q000235:genetics; D012326:RNA Splicing
chemical_list: D021382:Protein Sorting Signals; D011506:Proteins; D012313:RNA; D004247:DNA
vernacular_title: Evoliutsiia reguliatornykh belkov.