title: Childhood pulmonary blastoma: a pleuropulmonary variant of the adult-type pulmonary blastoma.
abstract: Two fatal childhood cases of the rare pulmonary blastoma are reported. One was associated with a congenital cystic adenomatoid malformation. Both neoplasms extended to involve visceral pleura and were entirely composed of blastemal and mesenchymal elements without recognizable neoplastic epithelial components. The mesenchymal component in both instances consisted of malignant rhabdomyoblasts, undifferentiated mesenchyme, and differentiated, apparently benign, cartilage. Review of the literature suggests that these features may be specific for the childhood forms of pulmonary blastoma. It is further suggested that pulmonary blastoma, malignant mesenchymoma of the lung, and primary pulmonary rhabdomyosarcoma may have a common pathogenetic origin.
authors.affiliation: Department of Pathology, Red Cross Children's Hospital, Cape, South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Emms
authors.forename: R O
authors.initials: RO
authors.lastname: Kaschula
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis; D002356:Cartilage / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D002675:Child, Preschool; D003893:Desmin / Q000032:analysis; D004848:Epithelium / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008648:Mesoderm / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009211:Myoglobin / Q000032:analysis; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013724:Teratoma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D002272:Carcinoembryonic Antigen; D003893:Desmin; D009211:Myoglobin; D009418:S100 Proteins; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D007633:Keratins; D010751:Phosphopyruvate Hydratase