[Contribution to the mechanism of the "factor VIII bypassing activity" (FEIBA)-reaction].
The principle of the FEIBactivity hadn't been defined in a sufficient manner up to now. Probably the factor VII or factor VIIa are playing a key role. According to own experiments the factor VII activity increases considerably in activated prothrombincomplex concentrates together with the quotient factor VIIa/VII. Factor VII should be administered in his activated form for bypassing. Fractions with limitation of the activation process to factor VII are of a low thrombogenicity. Among activated coagulation factors factor VIIa persists longest in the circulation and a bypass efficacy can be provoked only by this.
Sander
W
W
Bezirksinstitut für Blutspende- und Transfusionswesen Schwerin.
Wilms
K
K
D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000502:physiology*; D005167:Factor VII / Q000502:physiology; D005169:Factor VIII / Q000502:physiology*; D015942:Factor VIIa / Q000502:physiology; D006801:Humans
D001779:Blood Coagulation Factors; D005167:Factor VII; D005169:Factor VIII; D015942:Factor VIIa
Ein Beitrag zum Mechanismus der "Factor Eight Bypassing Activity" (FEIBA)-Wirkung.