Cytokeratin expression in the epithelia of the adult human cochlea.
Epithelia can be characterized by the specific expression pattern of their cytokeratin components. Therefore, we investigated the immunohistochemical expression of different cytokeratin subunits in frozen sections of chemically fixed, non-decalcified, adult human cochleas. The organ of Corti and the marginal cells of the stria vascularis showed reactivity for cytokeratin subunits 8, 18 and 19, whereas the other cochlear epithelia in addition expressed cytokeratin 7. The expression of cytokeratins 7, 8, 18 and 19 by the epithelia of the adult human cochlea is typical of "simple" epithelia. The deviant cytokeratin pattern of the organ of Corti and marginal cells of the stria vascularis may well reflect their differences in functional state and/or differentiation as compared to the other cochlear epithelia.
Bauwens
L J
LJ
Department of Otorhinolaryngology, University Hospital Utrecht, The Netherlands.
DeGroot
J C
JC
Ramaekers
F C
FC
Veldman
J E
JE
Huizing
E H
EH
D000328:Adult; D000368:Aged; D001489:Basilar Membrane / Q000737:chemistry; D003051:Cochlea / Q000737:chemistry*; D003053:Cochlear Duct / Q000737:chemistry; D004848:Epithelium / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D007633:Keratins / Q000032:analysis*; D008875:Middle Aged; D009925:Organ of Corti / Q000737:chemistry; D013316:Stria Vascularis / Q000737:chemistry
D007381:Intermediate Filament Proteins; D007633:Keratins