[The use of anti-keratin and anti-CEA monoclonal antibodies in the study of lacrimal epithelial tumors].
34 cases of lacrimal epithelial tumor were studied with the anti-keratin and anti-CEA monoclonal antibody peroxidase-anti-peroxidase staining and the AB/PAS mucohistochemical staining. It was found that HK2 was positive in the gland-luminal cells and cancer cells in the squamous metaplastic portion of the tumor; K12 was positive in the mucoid, fibroid, and cartilaginoid metaplastic tumor cells, while K27 was positive in less number of the squamous cells; CEA was positive in tumor cells of the nest and glandular lumina. Mecohistochemically, the tumor cells were 100% positive. The authors were of the opinion that keratin HK2 and K12 and CEA were ideal markers for lacrimal epithelial tumors.
Xing
H Q
HQ
Department of Pathology, Beijing PLA General Hospital.
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D003536:Cystadenocarcinoma / Q000175:diagnosis*; D005134:Eye Neoplasms / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000276:immunology*; D007766:Lacrimal Apparatus Diseases / Q000175:diagnosis*; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis*
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007633:Keratins