Histochemical detection of burn-induced lipid peroxidation in sebaceous glands of rat skin.
Increased lipid peroxide levels both in skin and serum have been reported after cutaneous thermal injury. However, it still remains unclear where lipid peroxides are produced at the site of burned skin. In the present study, a histochemical method using cold Schiff's reagent was applied in order to detect the localization of lipid peroxide. Schiff positivity was detected in sebaceous glands, and the extent of positivity seemed to correlate with the serum lipid peroxide levels. These results may suggest that lipid peroxides produced in sebaceous glands after thermal injury enter the blood stream and are partially responsible for the elevated serum lipid peroxide levels.
Kitajima
T
T
Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
Hamanaka
H
H
Miyachi
Y
Y
Ono
Y
Y
Moriguchi
T
T
Toyokuni
S
S
Imamura
S
S
D000818:Animals; D002056:Burns / Q000378:metabolism* / Q000473:pathology; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000032:analysis* / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012627:Sebaceous Glands / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000737:chemistry* / Q000378:metabolism / Q000473:pathology; D013194:Staining and Labeling; D013997:Time Factors
D008054:Lipid Peroxides