Effect of a prostacyclin analogue on the vasopressin and oxytocin secretion in vitro.
Iloprost (ZK 36374; a stable prostacyclin analogue) increases basal as well as potassium-evoked vasopressin and oxytocin secretion from rat neurointermediate lobes in vitro. This finding suggests a possible regulatory role of endogenous prostacyclin in the release of neurohypophysial hormones.
Bojanowska
E
E
Department of Pathophysiology, School of Medicine, Lódź, Poland.
Guzek
J W
JW
D000818:Animals; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000502:physiology; D016285:Iloprost / Q000494:pharmacology*; D008297:Male; D010121:Oxytocin / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000378:metabolism*
D014667:Vasopressins; D010121:Oxytocin; D011464:Epoprostenol; D016285:Iloprost