What is the ideal pulse frequency for skeletal muscle stimulation after cardiomyoplasty?
Routinely the latissimus dorsi (LD) muscle is stimulated with bursts of pulses at 30 pulses/sec after cardiomyoplasty to assist the failing heart. At a lower pulse frequency the contractile force decreases and at higher frequencies the energy demand of the pacemaker increases rapidly. We investigated the effect of the stimulus frequency variation on contractile force in untrained LD muscles and in muscles after 12 weeks of continuous cyclic electrical stimulation. In six dogs, two electrodes (Medtronic SP5528) were implanted in the left LD muscle together with an Itrel muscle stimulator. The LD muscle was stimulated with 30 pulses/sec in bursts to deliver initially 30 and after 10 weeks 80 contractions per minute. Both before and after training of the LD muscle maximum force was observed by stimulating with a frequency of 36 to 130 pulses/sec in a burst. However, training induced a shift in the steep part of the force-frequency relation to lower frequencies. In particular, at 15 pulses/sec 60% of the maximal force was obtained in contrast to 40% before training. A fatigue test of 8 minutes duration was performed specified by 100 bursts/min and a burst duration of 0.25 sec at pulse frequencies of 30, 36, 50, and 85 pulses/sec. The contractile force decreased significantly during the course of the test at all frequencies. However, the force obtained with 30 pulses/sec stimulation was lower during the initial phase and approximately 10% higher at the end of the fatigue test as compared to 36, 50, and 85 pulses/sec stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)
Lucas
C M
CM
Department of Cardiology, Academic Hospital Maastricht, The Netherlands.
van der Veen
F H
FH
Grandjean
P A
PA
Penn
O C
OC
Wellens
H J
HJ
D000818:Animals; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D006348:Cardiac Surgical Procedures; D004285:Dogs; D004558:Electric Stimulation; D005221:Fatigue / Q000503:physiopathology*; D009119:Muscle Contraction / Q000502:physiology*; D009132:Muscles / Q000033:anatomy & histology / Q000502:physiology* / Q000637:transplantation; D013314:Stress, Mechanical; D013997:Time Factors