Beta-carotene in prevention of cutaneous carcinogenesis.
Beta-carotene, administered orally to mice, caused a decrease in angiogenesis evoked by HPV-transformed tumorigenic cell lines (SKv-t, HeLa). It did not affect angiogenesis induced by the non-tumorigenic SKv (not-t) cell line, and increased lymphocyte-induced immune angiogenesis. We suggest that the anti-cancerogenic effect of beta-carotene may be due, at least in part, to its inhibitory effect on formation of new blood vessels within the tumour mass.
Szmurlo
A
A
Dermatology Department, Warsaw School of Medicine, Poland.
Marczak
M
M
Rudnicka
L
L
Majewski
S
S
Makiela
B
B
Skiendzielewska
A
A
Skopinska
M
M
Kornhauser
A
A
Jablonska
S
S
D000818:Animals; D002338:Carotenoids / Q000627:therapeutic use*; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008812:Mice, Hairless; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D012867:Skin / Q000098:blood supply; D012878:Skin Neoplasms / Q000098:blood supply / Q000517:prevention & control*; D019207:beta Carotene
D019207:beta Carotene; D002338:Carotenoids