Rat mast cells inhibit platelet aggregation by releasing a nitric oxide-like factor: influence of histamine release.
In th present paper we report the ability of rat serosal mast cells (MC) to release a nitric oxide (NO)-like factor by the inhibition of platelet aggregation and the effect of sodium nitroprusside (NaNP, a NO-generating drug) on MC histamine release by different stimuli.
Mannaioni
P F
PF
Department of Preclinical and Clinical Pharmacology, Florence, Italy.
Masini
E
E
Pistelli
A
A
Salvemini
D
D
Vane
J R
JR
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism* / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000494:pharmacology
D010975:Platelet Aggregation Inhibitors; D009599:Nitroprusside; D009569:Nitric Oxide; D000001:Calcimycin; D013917:Thrombin