[Production of immune interferon in experimental tuberculosis and antituberculosis vaccination in mice].
The serum content of interferon (IF) and its correlation with diverse immunologic parameters were studied in tuberculosis-resistant mice. In primary contamination the IF level was much higher in B10 mice highly sensitive to tuberculosis infection in all periods of the study than that in highly resistant A/Sn mice. In the vaccinated mice which were later infected this tendency remained but IF levels were 1.5--2 times higher than in primary contamination. Comparison of the IF level and the studied resistance parameters in the resistant mice revealed an inverse correlation. If the immunologic parameters in resistant A/Sn mice are higher than those in B10 mice the latter have significantly higher serum IF levels.
Bocharova
I V
IV
Maĭorov
K B
KB
Moroz
A M
AM
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage*; D007372:Interferons / Q000097:blood*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D014376:Tuberculosis / Q000276:immunology* / Q000517:prevention & control
D001500:BCG Vaccine; D007372:Interferons
Produktsiia immunnogo interferona pri éksperimental'nom tuberkuleze i protivotuberkuleznoĭ vaktsinatsii u mysheĭ.