title: Landau-Kleffner syndrome: epileptic activity in the auditory cortex.
abstract: The Landau-Kleffner syndrome (LKS) is characterized by electroencephalographic spike discharges and verbal auditory agnosia in previously healthy children. We recorded magnetoencephalographic (MEG) spikes in a patient with LKS, and compared their sources with anatomical information from magnetic resonance imaging. All spikes originated close to the left auditory cortex. The evoked responses were contaminated by spikes in the left auditory area and suppressed in the right--the latter responses recovered when the spikes disappeared. We suggest that unilateral discharges at or near the auditory cortex disrupt auditory discrimination in the affected hemisphere, and lead to suppression of auditory information from the opposite hemisphere, thereby accounting for the two main criteria of LKS.
authors.affiliation: Low Temperature Laboratory, Helsinki University of Technology, Espoo, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Paetau
authors.forename: M
authors.initials: M
authors.lastname: Kajola
authors.forename: M
authors.initials: M
authors.lastname: Korkman
authors.forename: M
authors.initials: M
authors.lastname: Hämäläinen
authors.forename: M L
authors.initials: ML
authors.lastname: Granström
authors.forename: R
authors.initials: R
authors.lastname: Hari
mesh_terms: D001037:Aphasia / Q000503:physiopathology*; D001303:Auditory Cortex / Q000503:physiopathology*; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D011930:Reaction Time; D013577:Syndrome