title: A case of hepatocellular carcinoma with the sign of Leser-Trelat: a possible role of a cutaneous marker for internal malignancy.
abstract: A rare case of hepatocellular carcinoma who developed the complication of the sign of Leser-Trelat is reported. The patient, a 57-year-old male, visited our hospital with complaints of generalized malaise and anorexia. A diagnosis of hepatocellular carcinoma was made based on elevated alpha-fetoprotein measurement, ultrasonography, and hepatic arteriography findings. Chest x-ray film suggested pulmonary metastases of hepatocellular carcinoma. Thereafter, complications of the seborrheic keratosis developed in the trunk and the skin lesion was diagnosed as the sign of Leser-Trelat associated with hepatocellular carcinoma. The patient died of pneumonia 9 months after development of the sign of Leser-Trelat.
authors.affiliation: First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Tajima
authors.forename: S
authors.initials: S
authors.lastname: Mitsuoka
authors.forename: E
authors.initials: E
authors.lastname: Ohtsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: Y
authors.initials: Y
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Shima
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: Y
authors.initials: Y
authors.lastname: Kusumoto
authors.forename: T
authors.initials: T
authors.lastname: Koji
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D001932:Brain Neoplasms / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000175:diagnosis / Q000556:secondary; D012628:Dermatitis, Seborrheic / Q000209:etiology*; D006801:Humans; D007642:Keratosis / Q000209:etiology*; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis; D008175:Lung Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins