[Study of chemically modified hemoglobin as an artificial oxygen carrier in the model of hemorrhagic shock in dogs].
Hemodynamic and gas-transporting properties of the chemically modified hemoglobin solution have been studied on the model of hemorrhagic shock in dog. It has been shown that the polymerized hemoglobin solution exerts the hemodynamic action just as the plasma substitute "polyglucin" does. However, in contrast to the latter, polyhemoglobin circulating in the vascular bed for a prolonged period of time increases the blood oxygen capacity and oxygen delivery to tissues with the resultant increase in body total oxygen taking-up.
Selivanov
E A
EA
Kochetygov
N I
NI
Gerbut
K A
KA
Azhigirova
M A
MA
Viazova
E P
EP
Zeĭnalov
A M
AM
Bystrova
I M
IM
Molokovskaia
E I
EI
D000818:Animals; D001802:Blood Substitutes; D003911:Dextrans; D004285:Dogs; D006439:Hemodynamics; D006454:Hemoglobins; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood; D012771:Shock, Hemorrhagic / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors
D001802:Blood Substitutes; D003911:Dextrans; D006454:Hemoglobins; C037158:polyhemoglobin; D010100:Oxygen
Izuchenie khimicheski modifitsirovannogo gemoglobina v kachestve iskusstvennogo perenoschika kisloroda na modeli gemorragicheskogo shoka u sobak.