title: Topical anesthesia with eutetic mixture of local anesthetics cream in vasectomy: 2 randomized trials.
abstract: Two paired randomized trials testing topical anesthesia with a eutetic mixture of local anesthetics (EMLA cream*) in vasectomy were performed. In 1 trial EMLA cream was applied on 1 side of the scrotum, while infiltration anesthesia into the skin and subcutaneous tissue with mepivacaine was used on the contralateral side. All but 1 of the 13 patients (p less than 0.05) preferred infiltration anesthesia because of pain as the incision reached the subcutaneous tissue. In the other trial 29 patients received EMLA cream on 1 side of the scrotum before bilateral mepivacaine infiltration. There was significantly less pain on the sides with the anesthetic cream (p less than 0.001). Many patients would pay the price of the cream. In conclusion, EMLA cream cannot replace but it can supplement infiltration anesthesia during vasectomy.
authors.affiliation: Department of Urology, Bispebjerg Hospital, University of Copenhagen, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Honnens de Lichtenberg
authors.forename: J
authors.initials: J
authors.lastname: Krogh
authors.forename: B
authors.initials: B
authors.lastname: Rye
authors.forename: J
authors.initials: J
authors.lastname: Miskowiak
mesh_terms: D000328:Adult; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004338:Drug Combinations; D006801:Humans; D007267:Injections; D008012:Lidocaine / Q000008:administration & dosage*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage; D008875:Middle Aged; D009824:Ointments; D010147:Pain Measurement; D011318:Prilocaine / Q000008:administration & dosage*; D014659:Vasectomy
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D008012:Lidocaine; D008619:Mepivacaine