Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs.
A hybrid vaccinia virus expressing a chimeric protein consisting of thymidine kinase and the encephalitogenic determinant, S1, from guinea pig myelin basic protein was constructed. Infection of guinea pigs with the virus resulted in the development of allergic encephalomyelitis.
Shchelkunov
S N
SN
All-Union Research Institute of Molecular Biology, Novosibirsk region.
Stavitskii
S B
SB
Batenko
L I
LI
Gashnikov
P V
PV
Shchelkunova
G A
GA
Kostyrev
O A
OA
Sandakhchiev
L S
LS
D000818:Animals; D001483:Base Sequence; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000382:microbiology* / Q000473:pathology; D006168:Guinea Pigs; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000502:physiology*; D011994:Recombinant Proteins / Q000737:chemistry; D013937:Thymidine Kinase / Q000502:physiology*; D014616:Vaccinia virus / Q000737:chemistry / Q000472:pathogenicity; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology*
D004676:Myelin Basic Protein; D011994:Recombinant Proteins; D014764:Viral Proteins; D013937:Thymidine Kinase