[Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia].
T cryptantigen can be exposed on the red cell membrane as a result of removal of terminal glycosides, either by bacterial enzymes or by incomplete synthesis of the cell membrane due to somatic mutation, usually caused by a neoplasm. T-activated erythrocytes have been observed in different pathologies, but they have not been seen associated with other abnormalities of red blood cell proteins described in myelodysplastic syndromes or acute leukaemias. A patient with initial diagnosis of refractory anaemia that evolved into erythroleukaemia showed prolonged T-activation, a depressed A blood-group antigen and an increase of foetal haemoglobin, simultaneously. The evolutive pattern of T-activation suggests more an abnormal erythropoiesis than an enzymatic effect and a certain relationship with the haemolytic syndrome.
Gioseffi
O N
ON
Hospital Nacional Profesor Alejandro Posadas, Servicio de Hematología, Buenos Aires, Argentina.
Del Río
F
F
Pardini
P
P
Kitagawa
M
M
D000017:ABO Blood-Group System; D000753:Anemia, Refractory / Q000097:blood* / Q000473:pathology; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides / Q000032:analysis*; D004920:Erythropoiesis; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D011289:Preleukemia / Q000097:blood
D000017:ABO Blood-Group System; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; C016467:Thomsen-Friedenreich antigen; D005319:Fetal Hemoglobin
Activación T eritrocítica prolongada, debilitamiento de grupo sanguíneo A y aumento de hemoglobina fetal en un síndrome mielodisplásico con evolución a eritroleucemia.