A 64 kDa protein from Mycobacterium bovis BCG shares the same antigenic determinants with line 10 hepatoma cells and has anti-line 10 tumor activity.
A 64 kilodalton (kDa) surface protein was isolated from the water-extracted materials from Mycobacterium bovis strain BCG, the determinants of which are antigenically shared by a 64 kDa major surface antigenic component of line 10 hepatoma cells. The 64 kDa protein showed anti-line 10 tumor activity in pre-immunized guinea pigs, and this suggest that the BCG 64 kDa protein is probably identical with the tumor specific antigen.
Ahsan
C R
CR
Department of Bacteriology, Hirosaki University School of Medicine, Japan.
Sasaki
J
J
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D016233:Immunotherapy, Active / Q000379:methods; D008114:Liver Neoplasms, Experimental / Q000276:immunology*; D008854:Microscopy, Electron; D009163:Mycobacterium bovis / Q000276:immunology*; D014407:Tumor Cells, Cultured
D000942:Antigens, Bacterial; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D000939:Epitopes