[Immobilized granulated drugs with magnetic properties based on nDNA, RNA, cardiolipin in the diagnosis and treatment of systemic lupus erythematosus].
To advance diagnosis and treatment of systemic lupus erythematosus (SLE), the authors have developed a number of specific diagnostic preparations basing on nDNA, RNA, cardiolipin immobilized into the three-dimensional lattice of polyacrylamide gel. Using such granulated antigenic preparations with magnetic properties, a correlation has been derived between SLE activity, visceral pathology and a level of specific antibodies. In view of a successful experimental use of the preparations as selective sorbents, they may be introduced into extracorporeal treatment. Immobilized granulated preparations can be used in immunofluorescent tests and enzyme immunoassays.
Zborovskiĭ
A B
AB
Gontar'
I P
IP
Levkin
S V
SV
Sycheva
G F
GF
Zavodovskiĭ
B V
BV
D001323:Autoantibodies / Q000032:analysis*; D002308:Cardiolipins / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007164:Immunosorbents; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008280:Magnetics; D012313:RNA / Q000276:immunology*
D001323:Autoantibodies; D002308:Cardiolipins; D007164:Immunosorbents; D012313:RNA; D004247:DNA
Immobilizovannye granulirovannye preparaty s magnitnymi svoĭstvami na osnove nDNK, RNK, kardiolipina v diagnostike i lechenii sistemnoĭ krasnoĭ volchanki.