title: Unexpectedly high toxicity of MACOP-B in young patients with low grade lymphoma.
abstract: We report the results of treatment with MACOP-B in 11 young patients with low grade lymphoma (LGL). Complete remission was obtained in 4 (57%) and partial remission in 3 (42.8%) of 7 evaluable patients. However, this aggressive chemotherapy has not offered any advantage because of an unacceptably high treatment-related morbidity and mortality (17%). Serious infection during neutropenia was the most common complication.
authors.affiliation: Servicio de Hematologia, Hospital de la Princesa, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Arranz
authors.forename: G
authors.initials: G
authors.lastname: Pérez
authors.forename: J L
authors.initials: JL
authors.lastname: Steegmann
authors.forename: R
authors.initials: R
authors.lastname: Cámara
authors.forename: J F
authors.initials: JF
authors.lastname: Tomás
authors.forename: A
authors.initials: A
authors.lastname: Figuera
authors.forename: L
authors.initials: L
authors.lastname: Vazquez
authors.forename: J M
authors.initials: JM
authors.lastname: Fernández-Rañada
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D007239:Infections / Q000209:etiology; D002955:Leucovorin / Q000009:adverse effects / Q000627:therapeutic use; D008223:Lymphoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects / Q000627:therapeutic use; D012074:Remission Induction; D016019:Survival Analysis; D014750:Vincristine / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate