title: Treatment of digital ischaemia associated with chemotherapy using the prostacyclin analogue iloprost.
abstract: Digital ischaemia is a recognised complication of both malignant disease and chemotherapy. Its onset may prevent further treatment and lead to tissue loss. We report a case of severe digital ischaemia in a patient with advanced breast carcinoma undergoing cytotoxic chemotherapy. This was successfully treated with Iloprost, a prostacyclin analogue.
authors.affiliation: Department of Vascular Surgery, St James's University Hospital, Leeds, U.K.
authors.forename: P
authors.initials: P
authors.lastname: Vowden
authors.forename: D
authors.initials: D
authors.lastname: Wilkinson
authors.forename: R C
authors.initials: RC
authors.lastname: Kester
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000188:drug therapy*; D003131:Combined Modality Therapy; D005260:Female; D005385:Fingers / Q000098:blood supply*; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D016285:Iloprost / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D007511:Ischemia / Q000139:chemically induced* / Q000188:drug therapy*; D008875:Middle Aged
chemical_list: D016285:Iloprost; D005472:Fluorouracil