title: Spectroscopic analysis of charge transfer complexes between morpholine and iodine.
abstract: It has been demonstrated spectroscopically that many nitrogen-containing heterocyclic compounds can form charge transfer complexes with iodine. The complexes of morpholine with iodine were shown to be of the n-sigma type with a 1:1 stoichiometry. A strong donor-acceptor interaction was found (Kc = 1261 +/- 12 mol-1 at 20 degrees C in CCl4), considerably higher than those of complexes of aromatic compounds with iodine. The high value of the formation constant for this complex indicated that morpholine could serve as a starting point for the synthesis of novel anti-thyroid drugs.
authors.affiliation: Laboratory of Chemical Pharmacy, Faculty of Pharmacy, Limoges University, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Lagorce
authors.forename: A C
authors.initials: AC
authors.lastname: Jambut-Absil
authors.forename: J
authors.initials: J
authors.lastname: Buxeraud
authors.forename: C
authors.initials: C
authors.lastname: Moesch
authors.forename: C
authors.initials: C
authors.lastname: Raby
mesh_terms: D013956:Antithyroid Agents / Q000138:chemical synthesis*; D007455:Iodine / Q000737:chemistry*; D009025:Morpholines / Q000737:chemistry*; D013053:Spectrophotometry
chemical_list: D013956:Antithyroid Agents; D009025:Morpholines; C037574:morpholine; D007455:Iodine