title: [Cyclic analogs of bradykinin, containing a carboxyl group].
abstract: 1 alpha-beta-carboxypropionyl-cyclo(9----1 epsilon)-[Lys1, Gly6]bradykinin (Suc-c[Lys1, Gly6]B), 1 alpha-beta-carboxypropionyl-cyclo(10----1 epsilon)kallidin (Suc-cK), cyclo(10 gamma----1 epsilon)-[Glu10]kallidin (c[Glu10]K) and cyclo(11 gamma----1 epsilon)kallidylglutamic acid (cKG) were synthesized. Suc-c[Lys1, Gly6]B and Suc-cK were prepared by acylating the appropriate cyclopeptides with succinic anhydride. c[Glu10]K and cKG were obtained by the classic peptide synthesis, the cyclization being carried out with 61 and 42% yields, respectively. The protecting groups were then eliminated by catalytic hydrogenation. c[Glu10]K and cKG exerted myotropic action on isolated rat uterus (alpha 0.73 and 0.89, pD2 6.61 and 8.61, respectively). cKG displayed direct myotropic activity with respect to electrically stimulated rat vas deferens and guinea-pig ileum, potentiating the contractions (by 100%) in response to electric stimuli. c[Glu10]K and cKG elicit histamine release in isolated rat mast cells (EC30 4.91.10(-5) and 1.47.10(-6) M, respectively). Both cyclopeptides alter arterial pressure following intravenous administration to anaesthetized rats, cats and dogs and affect heart rate. In all assays cKG is more active than c[Glu10]K. Suc-c[Lys1, Gly6]B and Suc-cK do not possess myotropic, histamine-releasing or hypotensive activity, though they were found to elicit a transient increase of bloodflow in cats and dogs.
authors.affiliation: Zentralinstitut für Molecularbiologie, AdW der DDR, Berlin.
authors.forename: I E
authors.initials: IE
authors.lastname: Mutule
authors.forename: F K
authors.initials: FK
authors.lastname: Mutulis
authors.forename: N V
authors.initials: NV
authors.lastname: Myshliakova
authors.forename: M M
authors.initials: MM
authors.lastname: Veveris
authors.forename: V V
authors.initials: VV
authors.lastname: Golubeva
authors.forename: E A
authors.initials: EA
authors.lastname: Porunkevich
authors.forename: M P
authors.initials: MP
authors.lastname: Ratkevich
authors.forename: G M
authors.initials: GM
authors.lastname: Strazda
authors.forename: V E
authors.initials: VE
authors.lastname: Klusha
authors.forename: Iu
authors.initials: Iu
authors.lastname: Bergmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin / Q000031:analogs & derivatives* / Q000235:genetics / Q000494:pharmacology; D002415:Cats; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D008969:Molecular Sequence Data; D009119:Muscle Contraction / Q000187:drug effects; D009215:Myometrium / Q000187:drug effects; D051381:Rats
chemical_list: D001920:Bradykinin
vernacular_title: Tsiklicheskie analogi bradikinina, soderzhashchie karboksil'nuiu gruppu.