title: Kinetics of the ontogenic and reversible hemoglobin switching in the mouflon (Ovis musimon) and sheep x mouflon hybrid.
abstract: 1. Hemoglobin (Hb) switching in the perinatal life of wild mouflon (Ovis musimon) was characterized by the replacement of Hb F by 60% levels of Hb C, and subsequently of Hb C by Hb B. 2. The recently discovered Hb M variant was not replaced by Hb C; thus, Hb BM heterozygote newborns synthesized 30% Hb C at the expense of Hb B. 3. Hybrid B mouflon x B sheep synthesized only 5% Hb C at birth but were able to produce 30% Hb C in adult life following induced anemia. 4. Adult BB and BM mouflons, after the same extent of induced anemia, synthesized HB C levels similar to those produced at birth. The results indicate a mouflon beta-globin gene cluster arrangement similar to those of sheep and goat, the beta C gene having an intermediate expression. Results also suggest a selective disadvantage in hybrid animals.
authors.affiliation: Istituto di Fisiologia Generale e Chimica Biologica, Università di Sassari, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Masala
authors.forename: L
authors.initials: L
authors.lastname: Manca
authors.forename: E
authors.initials: E
authors.lastname: Cocco
authors.forename: S
authors.initials: S
authors.lastname: Ledda
authors.forename: S
authors.initials: S
authors.lastname: Naitana
mesh_terms: D000818:Animals; D005319:Fetal Hemoglobin / Q000235:genetics*; D006444:Hemoglobin C / Q000235:genetics*; D006824:Hybridization, Genetic; D007700:Kinetics; D010641:Phenotype; D012418:Ruminants / Q000097:blood* / Q000235:genetics / Q000254:growth & development; D012756:Sheep / Q000097:blood* / Q000235:genetics / Q000254:growth & development
chemical_list: D006444:Hemoglobin C; D005319:Fetal Hemoglobin