Ph-positive chronic myeloid leukemia with t(8;21)(q22;q22) in blastic crisis.
A patient diagnosed with chronic myeloid leukemia was studied periodically during his illness. The result showed the presence of a Philadelphia (Ph) chromosome by a 9;22 translocation as a single abnormality to the time of blastic crisis. At that time, the chromosome studies showed a clonal evolution. Furthermore, a second derivated line was added to the Ph line. This new anomaly consisted of a 8;21 translocation, considered as specific of M2 type acute nonlymphoblastic leukemia of French-American-British classification.
Ferro
M T
MT
Medical Genetics Department, Hospital Ramón y Cajal, Madrid, Spain.
Steegman
J L
JL
Escribano
L
L
Heiurichs
B
B
Parada
L
L
García-Sagredo
J M
JM
Resino
M
M
Cabello
P
P
San Román
C
C
D000328:Adult; D001752:Blast Crisis; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic