Immunologic aspects of fibrosis in mouse mammary carcinomas.
The nature of the fibrosis associated with mammary carcinomas MC2 and MC3 was investigated in syngeneic C3H mice. Accelerated and enhanced peri-tumor cellular and fibrotic responses and retarded tumor growth were observed in actively immunized and in adoptively immunized mice, and in mice treated with IL-2. T lymphocytes and, particularly, macrophages were closely associated with collagen deposition at the tumors. The collagen deposition frequently resulted in the encapsulation and regression of the less invasive tumor MC2. A cellular fibrous response was not observed at tumors implanted into athymic C3Hnu/nu mice. The results suggest that tumor fibrosis may in some circumstances be promoted by an immune response.
Vaage
J
J
Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263.
D000818:Animals; D002277:Carcinoma / Q000276:immunology / Q000473:pathology*; D005355:Fibrosis / Q000276:immunology / Q000473:pathology; D007114:Immunization; D007116:Immunization, Passive; D007376:Interleukin-2 / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D007376:Interleukin-2