In vivo lipid and amino acid synthesis from 3-hydroxybutyrate in 15-day-old chick.
The in vivo utilization of 3-hydroxybutyrate for lipid and amino acid synthesis in liver, kidney and duodenal mucosa of overnight-starved 15-day-old chicks has been investigated. Lipid synthesis was higher in liver and duodenal mucosa than in kidney. Triglycerides were the main lipids synthesized from 3-hydroxybutyrate in liver and kidney, while in duodenal mucosa a higher amount of phospholipids was observed. This tissue utilized a high percentage of 3-hydroxybutyrate for the synthesis of free cholesterol, in agreement with the major role of intestine in body cholesterogenesis. All of the assayed tissues synthesized amino acids from 3-hydroxybutyrate at a similar rate, glutamate being always the main amino acid formed.
Caamaño
G J
GJ
Departamento de Bioquímica y Biología Molecular, Universidad de Granada, Spain.
Sanchez-Del-Castiool
M A
MA
Linares
A
A
Garcia-Peregrin
E
E
D020155:3-Hydroxybutyric Acid; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002645:Chickens; D004386:Duodenum / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D018698:Glutamic Acid; D006885:Hydroxybutyrates / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D000596:Amino Acids; D005971:Glutamates; D006885:Hydroxybutyrates; D010743:Phospholipids; D014280:Triglycerides; D018698:Glutamic Acid; D020155:3-Hydroxybutyric Acid