title: Oxygen-exacerbated bleomycin pulmonary toxicity.
abstract: Bleomycin is an antineoplastic agent with potential for producing pulmonary toxicity, attributed in part to its free radical-promoting ability. Clinical and research experiences have suggested that the risk of bleomycin-induced pulmonary injury is increased with the administration of oxygen. We report a case in which the intraoperative administration of oxygen in the setting of previous bleomycin therapy contributed to postoperative ventilatory failure. Our patient recovered with corticosteroid therapy. Physician awareness of a potential interaction between oxygen and bleomycin may help reduce the morbidity and mortality related to bleomycin therapy.
authors.affiliation: Division of Thoracic Diseases, Mayo Clinic, Rochester, MN 55905.
authors.forename: T S
authors.initials: TS
authors.lastname: Ingrassia
authors.forename: J H
authors.initials: JH
authors.lastname: Ryu
authors.forename: V F
authors.initials: VF
authors.lastname: Trastek
authors.forename: E C
authors.initials: EC
authors.lastname: Rosenow
mesh_terms: D000208:Acute Disease; D000328:Adult; D001761:Bleomycin / Q000009:adverse effects*; D004357:Drug Synergism; D006801:Humans; D007430:Intraoperative Care; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*; D012086:Reoperation; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*
chemical_list: D001761:Bleomycin