title: Modulation of humoral immune responses by Tinospora malabarica in experimental animals.
abstract: Effect of alkaloidal fraction of aqueous extract of T. malabarica (Tm) was studied on humoral antibody responses in rats and guineapigs. The anti-SRBC haemagglutination titre was found to be enhanced in rats pretreated with Tm (2.5 mg/kg). Passive cutaneous anaphylaxis (PCA) in rats was also increased in Tm treated group. In vitro experiments with sensitized rat peritoneal mast cells showed a significant decrease in antigen-induced various spasmogens on isolated guineapig ileum.
authors.affiliation: Department of Pharmacology, University College of Medical Sciences & GT Hospital, Delhi, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
authors.forename: P C
authors.initials: PC
authors.lastname: Maity
authors.forename: P
authors.initials: P
authors.lastname: Mediratta
authors.forename: P
authors.initials: P
authors.lastname: Sen
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006384:Hemagglutination / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D010936:Plant Extracts