title: PUVA increases ornithine decarboxylase gene expression in mouse skin.
abstract: The influence of topical PUVA on the activity of ornithine decarboxylase (ODC) and its gene expression was investigated in the skin of hairless mouse. After 1 h of application of 0.3% 8-methoxypsoralen, irradiation of 3 J/cm2 of ultraviolet A (UV-A) was administered. The ODC activity markedly increased and peaked at 24 h following UV-A irradiation. The ODC mRNA level, analyzed in dot-blot analysis, elevated to about 5 times that of control at 24 h after treatment. These results show that the PUVA-induced ODC activity is due in part to an increase in ODC gene expression.
authors.affiliation: Department of Dermatology, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kono
authors.forename: N
authors.initials: N
authors.lastname: Mizuno
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: I
authors.initials: I
authors.lastname: Matsui-Yuasa
authors.forename: S
authors.initials: S
authors.lastname: Otani
authors.forename: T
authors.initials: T
authors.lastname: Hamada
mesh_terms: D000818:Animals; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000528:radiation effects*; D051379:Mice; D009955:Ornithine Decarboxylase / Q000235:genetics* / Q000378:metabolism; D011701:PUVA Therapy; D012313:RNA / Q000032:analysis; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*
chemical_list: D012313:RNA; D009955:Ornithine Decarboxylase