title: Treatment of supraventricular tachyarrhythmias associated with hyperthyroidism by radioiodine, amiodarone and propylthiouracil.
abstract: Beta-blockers and calcium antagonists have been advocated for thyrotoxicosis induced tachyarrhythmias. Amiodarone is generally considered as contraindicated because of its high iodine content. Since amiodarone combined with propylthiouracil induced a greater fall in serum thyroid hormone concentrations than propylthiouracil alone, we treated 2 hyperthyroid patients with supraventricular arrhythmias by radioiodine (day 0) followed after 24 h by amiodarone and propylthiouracil. Serum T3 was normalized on day 2 (patient 1) and 3 (patient 2). Effective t1/2 of intrathyroidal 131I were 6.6 and 4.3 days (versus 5.9 days for 131I given alone). In patient 1, atrial fibrillation, reverted to sinus rhythm after verapamil and digoxin, and did not recur. In patient 2, conversion of atrial fibrillation to sinus rhythm occurred on day 11; from day 0 to day 11, ventricular rate decreased and was significantly correlated to T3 (r = 0.82; p < 0.05). In conclusion, amiodarone may be beneficial in thyrotoxicosis associated tachyarrhythmias, given with propylthiouracil 24 h after radioiodine, it did not decrease thyroid irradiation and rapidly decreased serum T3.
authors.affiliation: Department of Endocrinology, Erasme Hospital, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Unger
authors.forename: N
authors.initials: N
authors.lastname: Mavroudakis
authors.forename: A
authors.initials: A
authors.lastname: Lipski
authors.forename: A
authors.initials: A
authors.lastname: van Coevorden
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications*; D007455:Iodine / Q000652:urine; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D011441:Propylthiouracil / Q000627:therapeutic use*; D013617:Tachycardia, Supraventricular / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D014284:Triiodothyronine; D011441:Propylthiouracil; D007455:Iodine; D000638:Amiodarone; D013974:Thyroxine