Genotoxicity of beryllium, gallium and antimony in short-term assays.
The genotoxicity of beryllium, gallium and antimony compounds was studied with the rec, Salmonella mutagenicity and SCE assays. In the rec assay, all the salts of the metals, BeCl2, Be(NO3)2, GaCl3, Ga(NO3)3, SbCl3, SbCl5, and an oxide, Sb2O3, had DNA-damaging activity. None of the compounds was mutagenic to Salmonella. In the SCE assays using V79 cells, 2 antimony(III) compounds, SbCl3 and Sb2O3, and 2 beryllium compounds, BeCl2 and Be(NO3)2, induced SCEs significantly. Sb2O3, slightly soluble in water, was positive in both the rec assay and the SCE assay at very low doses.
Kuroda
K
K
Osaka City Institute of Public Health and Environmental Sciences, Japan.
Endo
G
G
Okamoto
A
A
Yoo
Y S
YS
Horiguchi
S
S
D000818:Animals; D000965:Antimony / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001608:Beryllium / Q000494:pharmacology*; D002460:Cell Line; D004249:DNA Damage; D005708:Gallium / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013329:Structure-Activity Relationship
D009153:Mutagens; D000965:Antimony; D005708:Gallium; D001608:Beryllium