[Demonstration and biological significance of viral and cellular oncogenes in uterine carcinomas].
Premalignant and malignant lesions of the cervix uteri and endometrium were analyzed for the presence of human papillomavirus (HPV) DNA and c-myc or c-erbB2/neu oncogene expression. HPV DNA was detected by PCR in 100% of the cervical carcinomas and CIN lesions, but also in endometrial lesions (3/8 adenocarcinomas, two hyperplasias and one adenomyosis uteri). Myc-overexpression was found in 25-30% of the cervical carcinomas and severe dysplasias, but not in endometrial lesions. C-erbB2 was overexpressed in 4/11 endometrial carcinomas and 3/19 CIN3 lesions. The implications of these results are discussed.
Milde-Langosch
K
K
Ab'. Gynäkologische Histopathologie, Univ.-Frauenklinik, Hamburg.
Wilckens
C
C
Brack
T
T
Löning
T
T
D014408:Biomarkers, Tumor / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000382:microbiology; D005260:Female; D016259:Genes, myc; D006801:Humans; D009857:Oncogenes; D027383:Papillomaviridae / Q000302:isolation & purification*; D011230:Precancerous Conditions / Q000235:genetics* / Q000382:microbiology*; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000235:genetics; D011519:Proto-Oncogenes; D018719:Erb-b2 Receptor Tyrosine Kinases; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000382:microbiology*; D014594:Uterine Neoplasms / Q000235:genetics* / Q000382:microbiology*
D014408:Biomarkers, Tumor; D004279:DNA, Viral; D011518:Proto-Oncogene Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases
Nachweis und biologische Bedeutung von Viren und Onkogenen bei Uteruskarzinomen.