Whole body elimination routes of gold in humans after a single-dose application of the antirheumatic auranofin.
After removal of the gallbladder (cholecystectomy) 7 patients were administered the antirheumatic agent Auranofin in its commercially available tablet form (Ridaura) 3 d postoperative. The single dose consisted of 5 tablets (4.35 mg of gold). Gold was determined in samples of blood, plasma, urine, bile, and feces (1-2 mL and 2.5 g, respectively). The specimens were drawn 10 min to 8 d p.a. and on d 14 p.a. The determinations were performed by instrumental neutron activation analysis (INAA). The limit of detection was less than 1 ng of gold. The courses of the mean gold concentrations show maxima after 1.9 h in blood and plasma, and after 16 h in urine and bile. The mean half-lives (terminal phases) are 7.6 d (blood), 23 d (plasma), and 6.5 d (bile).
Schnier
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C
Institute of Physics, GKSS Research Centre, Geesthacht, FRG.
Benn
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HP
D000368:Aged; D001310:Auranofin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002763:Cholecystectomy; D005260:Female; D006046:Gold / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009501:Neutron Activation Analysis; D014018:Tissue Distribution
D001310:Auranofin; D006046:Gold