[Effects of an epiphyseal peptide preparation epithalamin on serotonin metabolism in the pineal gland of rats].
5-day morning injections to pubertal male rats of polypeptide epithalamin preparation obtained from cattle epiphysis, in dose of 0.25 mg/100 g body mass induced the increase of serotonin epiphyseal concentration night peak, N-acetylserotonin and melatonin and didn't produce any essential influence on 5-methoxytryptamine, 5-oxy- and 5-methoxyindoleacetic acid level. It has been concluded, that epiphyseal peptides and indoles interact according to ultrashort connection, epiphyseal peptides point of application is the reaction of tryptophan transformation into serotonin and its further metabolism in N-acetylserotonin and melatonin. It has been suggested that the increase of epiphyseal melatonin production is on the basis of epithalamin therapeutic action.
Bondarenko
L A
LA
Anisimov
V N
VN
D008735:5-Methoxytryptamine / Q000378:metabolism; D000818:Animals; D002417:Cattle; D006897:Hydroxyindoleacetic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000378:metabolism; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism*; D013997:Time Factors
D010455:Peptides; D012701:Serotonin; C001736:5-methoxyindoleacetic acid; D008735:5-Methoxytryptamine; D006897:Hydroxyindoleacetic Acid; C027437:epithalamin; D008550:Melatonin; C006389:N-acetylserotonin
Vliianie peptidnogo preparata épifiza épitalamina na metabolizm serotonina v shishkovidnoĭ zheleze u krys.