[Anti-nucleic acid antibodies in children with systemic lupus erythematosus and systemic scleroderma and in their relatives living with the probands].
The nature of antibodies to nucleic acids was studied in children of a Caucasian region suffering from systemic lupus erythematosus (SLE) and systemic sclerodermia (SSD). Two types of antibodies (to two- and one-filament DNA) were revealed in SLE, and in SSD mainly--to one-filament DNA. Antibodies to RNA in patients with SLE were specific for two-filament conformation. Immunogenesis disorders of different degree with respect to DNA and RNA were found; this expressed itself in the synthesis of various classes of immunoglobulins to these antibodies (IgG to DNA and IgM to RNA). High incidence of the RNA-binding activity of relatives living together with probands is noted. These data point to a high occurrence of antibodies to denatured DNA and low incidence of the cases of DNA-binding activity in the blood sera of the patients' fathers and brothers. Thus a combination of three factors: viral, genetic and hormonal in the pathogenesis of this disease is possible.
Adamashvili
I M
IM
Makarova
O V
OV
Zamchuk
L A
LA
Gvardzhaladze
T V
TV
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D001666:Binding Sites, Antibody / Q000235:genetics / Q000276:immunology; D002648:Child; D004247:DNA / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D007075:Immunoglobulin M / Q000032:analysis / Q000235:genetics / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology*; D008297:Male; D012313:RNA / Q000235:genetics / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000235:genetics / Q000276:immunology*; D012737:Sex Factors
D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012313:RNA; D004247:DNA
Antitela k nukleinovym kislotam u deteĭ, bol'nykh sistemnoĭ krasnoĭ volchankoĭ i sistemnoĭ sklerodermieĭ, i u ikh rodstvennikov, zhivushchikh sovmestno s probandami.