title: [Normal immune function in highly malignant non-Hodgkin's lymphomas].
abstract: We performed lymphocyte transformation tests using 14 different mitogens and antigens, determined T-cell- and T-cell subpopulation counts (CD3, CD4, CD8), the CD4/8 ratio, granulocyte chemotaxis and granulocyte adherence in 88 healthy controls, 8 patients with immunoblastoma (IB) and 6 patients with lymphoblastoma (LB). Using cluster and discrimination analyses (F-test; t-test) according to the programs of the UCLA (BMDP2N) the control group (n = 88) could be divided into 3 groups with significantly different lymphocyte responses to mitogenic and antigenic stimulation (21 high-, 18 medium, and 49 low responders). Comparing the lymphocyte reactivity of IB and LB patients to these immunofunctional different clusters we found a complete accordance of the lymphoma patients to the healthy low responder group.
authors.affiliation: Abteilung Innere Medizin, Universitätsklinikum Rudolf Virchow Standort Charlottenburg, Freie Universität Berlin.
authors.forename: T
authors.initials: T
authors.lastname: Zeiler
authors.forename: V
authors.initials: V
authors.lastname: Weisbach
authors.forename: J
authors.initials: J
authors.lastname: Zingsem
authors.forename: H G
authors.initials: HG
authors.lastname: Heuft
authors.forename: W
authors.initials: W
authors.lastname: Mempel
authors.forename: W
authors.initials: W
authors.lastname: Wilmanns
authors.forename: R
authors.initials: R
authors.lastname: Eckstein
mesh_terms: D000328:Adult; D000368:Aged; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D016176:T-Lymphocyte Subsets / Q000276:immunology*
vernacular_title: Normale Immunfunktion bei hochmalignen Non-Hodgkin-Lymphomen.