title: Visceral metastases from melanoma: findings on MR imaging.
abstract: Typical ocular and CNS melanomas are hyperintense on T1-weighted MR images and hypointense on T2-weighted MR images. We performed MR imaging in 48 patients with melanoma metastatic to visceral organs. Images were reviewed retrospectively in order to determine whether there were predominant MR features specific for visceral melanoma and to see if visceral metastases have MR characteristics similar to metastases in the CNS. Eleven patients also were examined after injection of gadopentetate dimeglumine to evaluate the enhancement characteristics of these tumors. Two hundred sixty-one lesions were found. Lesions were classified according to their signal intensities relative to uninvolved liver on T1-weighted, T2-weighted, and short TI inversion recovery (STIR) pulse sequences. Most commonly, lesions were either hypointense or isointense on T1-weighted sequences and hyperintense on T2-weighted and STIR sequences (185 lesions). Less frequently, lesions were hyperintense on T1-weighted sequences and hypointense or isointense on T2-weighted and STIR sequences (59 lesions). A mixed pattern was seen on T1- and T2-weighted sequences in 17 lesions. The patterns did not correlate with lesion size. Of the three sequences studied by subjective comparison, the STIR sequence in our series had the highest sensitivity for lesion detection and yielded the highest lesion conspicuity. Injection of gadopentetate dimeglumine in 11 patients did not increase either the number or the conspicuity of lesions seen. Our results show that visceral metastases from melanoma have a wide variety of appearances on MR images. The STIR sequence appears to be optimal, and the metastases do not enhance with gadopentetate dimeglumine.
authors.affiliation: Department of Diagnostic Radiology, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892.
authors.forename: A
authors.initials: A
authors.lastname: Premkumar
authors.forename: L
authors.initials: L
authors.lastname: Sanders
authors.forename: F
authors.initials: F
authors.lastname: Marincola
authors.forename: I
authors.initials: I
authors.lastname: Feuerstein
authors.forename: R
authors.initials: R
authors.lastname: Concepcion
authors.forename: D
authors.initials: D
authors.lastname: Schwartzentruber
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D000328:Adult; D016543:Central Nervous System Neoplasms / Q000473:pathology; D003287:Contrast Media; D004338:Drug Combinations; D005134:Eye Neoplasms / Q000473:pathology; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary*; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D008536:Meglumine; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary*; D009942:Organometallic Compounds; D004369:Pentetic Acid; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000556:secondary*
chemical_list: D003287:Contrast Media; D004338:Drug Combinations; D009942:Organometallic Compounds; D008536:Meglumine; D004369:Pentetic Acid; D019786:Gadolinium DTPA