Protein glycation: effects upon protein recognition by the proximal tubule.
Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different explanations considered, we think molecular charge of the protein seems to be a key factor for the altered recognition of glycated albumin by the proximal tubule.
Kowluru
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Life Sciences Division, Los Alamos National Laboratory, University of California, New Mexico 87545.
Kowluru
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Solomon
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Martinez
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D000818:Animals; D001692:Biological Transport; D017127:Glycation End Products, Advanced; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000093423:Glycated Serum Albumin
D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin