title: Parotid salivary secretion in diabetic autonomic neuropathy.
abstract: Parotid salivary flow rates and amylase concentrations were measured in three groups of eight subjects each (normal control, non-neuropathic diabetic, and neuropathic diabetic). Flow rates were significantly reduced in neuropathic diabetic patients as compared with normal controls (p less than 0.001) and non-neuropathic diabetic patients (p less than 0.02). Amylase concentrations were similar. These data are consistent with parasympathetic denervation of the parotid gland in diabetic neuropathy and provide evidence for a widespread distribution of autonomic denervation in diabetes.
authors.affiliation: Department of Medicine, Bristol Royal Infirmary, England.
authors.forename: P G
authors.initials: PG
authors.lastname: Newrick
authors.forename: C
authors.initials: C
authors.lastname: Bowman
authors.forename: D
authors.initials: D
authors.lastname: Green
authors.forename: I A
authors.initials: IA
authors.lastname: O'Brien
authors.forename: S R
authors.initials: SR
authors.lastname: Porter
authors.forename: C
authors.initials: C
authors.lastname: Scully
authors.forename: R J
authors.initials: RJ
authors.lastname: Corrall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000681:Amylases / Q000032:analysis; D001342:Autonomic Nervous System Diseases / Q000503:physiopathology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D010306:Parotid Gland / Q000378:metabolism*; D012463:Saliva / Q000737:chemistry
chemical_list: D000681:Amylases