title: Adverse cutaneous reactions due to macrolides.
abstract: Macrolides, which are widely prescribed and seldom produce hypersensitivity reactions, are considered to be safe drugs. We present five patients with generalized skin reactions due to erythromycin and/or spiramycin, proved by oral challenge tests. One patient showed reactions to both erythromycin and spiramycin. All skin prick and patch tests and histamine release tests with both macrolides were negative.
authors.affiliation: Servicio de Alergia, Hospital Ramon y Cajal, Carretera de Colmenar, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Igea
authors.forename: S
authors.initials: S
authors.lastname: Quirce
authors.forename: B
authors.initials: B
authors.lastname: de la Hoz
authors.forename: J
authors.initials: J
authors.lastname: Fraj
authors.forename: J
authors.initials: J
authors.lastname: Pola
authors.forename: M L
authors.initials: ML
authors.lastname: Diez Gomez
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D004917:Erythromycin / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D006636:Histamine Release / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D012882:Skin Tests; D015572:Spiramycin / Q000009:adverse effects / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D007073:Immunoglobulin E; D004917:Erythromycin; D015572:Spiramycin