Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure.
When introduced intranasally, P. cepacia AC1100 (approximately 10(8) CFU/animal) and P. aeruginosa AC869 (approximately 10(3) CFU/animal) were readily cleared from the mouse. However, a approximately 10(7)-CFU dose of AC869 persisted for 14 days. Strain AC869 had a 50% lethal dose of 2.7 x 10(7) CFU. Slight morbidity occurred in animals treated with approximately 10(7) CFU of AC869 or approximately 10(8) CFU of AC1100.
George
S E
SE
Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
Kohan
M J
MJ
Whitehouse
D A
DA
Creason
J P
JP
Kawanishi
C Y
CY
Sherwood
R L
RL
Claxton
L D
LD
D000281:Administration, Intranasal; D000818:Animals; D016956:Burkholderia cepacia / Q000472:pathogenicity*; D003264:Containment of Biohazards; D004783:Environmental Microbiology; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*