title: Role of intracellular cation abnormalities in development of left ventricular hypertrophy.
abstract: To elucidate factors determining the development of left ventricular hypertrophy, we performed measurements of intraerythrocyte sodium and intraplatelet calcium concentrations, measurements of plasma and urinary catecholamine levels and plasma renin activity, calculation of left ventricular mass using echocardiography, and 24-h ambulatory blood pressure (BP) monitoring. The results indicate that abnormalities of sodium and calcium mobilization may play an important role in the adaptation of left ventricular muscle to a persistent increase in BP.
authors.affiliation: First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: T
authors.initials: T
authors.lastname: Shingu
authors.forename: T
authors.initials: T
authors.lastname: Kawagoe
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Kainouchi
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: R
authors.initials: R
authors.lastname: Ozono
authors.forename: G
authors.initials: G
authors.lastname: Kajiyama
mesh_terms: D000328:Adult; D001794:Blood Pressure; D002118:Calcium / Q000097:blood*; D006332:Cardiomegaly / Q000209:etiology*; D002851:Chromatography, High Pressure Liquid; D004452:Echocardiography; D004837:Epinephrine / Q000097:blood / Q000652:urine; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood / Q000652:urine; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood*
chemical_list: D012964:Sodium; D012083:Renin; D002118:Calcium; D009638:Norepinephrine; D004837:Epinephrine