title: Expression of the CD2 activation epitope T11-3 (CD2R) on T cells in rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease: phenotypic and functional analysis.
abstract: CD2R is an activation-associated epitope unmasked by a conformational change of the CD2 cell-surface glycoprotein. In spite of elaborate studies on the role of CD2 and CD2R in adhesion and stimulation of T cells in vitro, no instances of CD2R expression in vivo were known to date. We report high levels of CD2R observed on blood and synovial fluid T cells in rheumatoid arthritis and on peripheral blood T cells in juvenile rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and Lyme disease. In vivo, expression of CD2R was restricted to T cells, not limited to a particular T-cell subset and not correlated with the expression of p55 interleukin 2R (IL-2R) (CD25) or major histocompatibility complex (MHC) class II molecules. When stimulated to proliferation via CD2 or CD3, ex vivo CD2R+ T cells showed the same basic activation requirements as CD2R-T cells.
authors.affiliation: Max-Planck-Society Research Unit for Rheumatology/Immunology, University of Erlangen, Germany.
authors.forename: A J
authors.initials: AJ
authors.lastname: Potocnik
authors.forename: H
authors.initials: H
authors.lastname: Menninger
authors.forename: S Y
authors.initials: SY
authors.lastname: Yang
authors.forename: K
authors.initials: K
authors.lastname: Pirner
authors.forename: A
authors.initials: A
authors.lastname: Krause
authors.forename: G R
authors.initials: GR
authors.lastname: Burmester
authors.forename: B M
authors.initials: BM
authors.lastname: Bröker
authors.forename: P
authors.initials: P
authors.lastname: Hept
authors.forename: G
authors.initials: G
authors.lastname: Weseloh
authors.forename: H
authors.initials: H
authors.lastname: Michels
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D001168:Arthritis / Q000235:genetics / Q000276:immunology*; D001171:Arthritis, Juvenile / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D018801:CD2 Antigens; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008193:Lyme Disease / Q000276:immunology*; D008213:Lymphocyte Activation; D010641:Phenotype; D011971:Receptors, Immunologic / Q000502:physiology*; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D000939:Epitopes; D011971:Receptors, Immunologic