The induction of adipose conversion in 3T3-L1 cells is associated with early phosphorylation of a 60-kDa nuclear protein.
The induction of adipose conversion in 3T3-L1 cells by bezafibrate has been shown to be enhanced by dibutyryl-cAMP. We here report that the induction of adipose conversion in 3T3-L1 cells, by either bezafibrate and dibutyryl cAMP, or isobutylmethyxanthine alone, is associated with a very early phosphorylation of a 60-kDa acidic protein found in the nuclear fraction.
Brandes
R
R
Department of Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Arad
R
R
Bar-Tana
J
J
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000273:Adipose Tissue / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D001629:Bezafibrate / Q000494:pharmacology; D003994:Bucladesine / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D004357:Drug Synergism; D015180:Electrophoresis, Gel, Two-Dimensional; D005347:Fibroblasts; D051379:Mice; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation
D009687:Nuclear Proteins; D003994:Bucladesine; D015056:1-Methyl-3-isobutylxanthine; D001629:Bezafibrate