HLA-A29.2 subtype associated with birdshot retinochoroidopathy.
Birdshot retinochoroidopathy is strongly associated with HLA-A29. This antigen can be divided into two subtypes, A29.1 and A29.2, using an immunoprecipitation method succeeded by one-dimensional electrofocusing gel electrophoresis. We reviewed the HLA typings of 58 white French patients who had birdshot retinochoroidopathy. Of these 58 subjects, 54 (93.1%) had HLA-A29 with a relative risk of 157.30. We further analyzed the HLA-A29 subtypings of 33 patients with birdshot retinochoroidopathy. Evaluation of the results showed that HLA-A29.2 subtype was present in all patients (100%). We concluded that the absence of HLA-A29.1 subtype is statistically significant (P less than .01) in this study of HLA-A29 subtyping.
LeHoang
P
P
Department of Ophthalmology, Pitié-Salpêtrière Hospital, University of Paris, France.
Ozdemir
N
N
Benhamou
A
A
Tabary
T
T
Edelson
C
C
Betuel
H
H
Semiglia
R
R
Cohen
J H
JH
D000293:Adolescent; D000328:Adult; D000368:Aged; D002825:Chorioretinitis / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D008040:Genetic Linkage / Q000276:immunology; D015234:HLA-A Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D015234:HLA-A Antigens; C035524:HLA-A29 antigen