Motor evoked potentials and central motor conduction: studies of transcranial magnetic stimulation with recording from the leg.
To determine central conduction times in the corticospinal pathways of humans using magnetic stimulation, we have developed a method for consistently recording conduction times between the motor cortex and the L4-5 level of the spinal cord. In 30 subjects, motor evoked potentials (MEPs) were recorded from the tibialis anterior muscle following contralateral motor cortex and peroneal nerve stimulation. In 18 of these subjects, the L4-5 intervertebral space was stimulated. The stimuli consisted of single, painless, short-duration magnetic pulses. In 12 subjects, measurements were made during voluntary ankle dorsiflexion, and during vibration of the TA tendon at rest. All subjects had measureable MEP latencies of 30.3 +/- 2.2 msec (mean +/- S.D.). The central motor conduction time (CMCT) was calculated using both a direct as well as an indirect method. The direct method in 18 subjects had a mean value of 16.2 +/- 1.7 msec, while the indirect method in all 30 subjects was 13.8 +/- 1.8 msec. No significant correlation of the CMCT was found with either age or height in these subjects. Ankle dorsiflexion significantly reduced the MEP latency and increased the amplitude, whereas vibration of the TA tendon significantly increased the amplitude alone. We conclude that MEPs may be consistently and painlessly measured in the lower extremity using magnetic stimulation in adults. Facilitation of the MEPs was produced more consistently by voluntary contraction than by vibratory stimulation of the tibialis anterior muscle tendon. Finally, CMCT was independent of both age and height in our study population.
Booth
K R
KR
Department of Neurology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
Streletz
L J
LJ
Raab
V E
VE
Kerrigan
J J
JJ
Alaimo
M A
MA
Herbison
G J
GJ
D000328:Adult; D000375:Aging / Q000502:physiology; D001827:Body Height; D002490:Central Nervous System / Q000502:physiology*; D005071:Evoked Potentials; D006801:Humans; D007866:Leg / Q000294:innervation; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009431:Neural Conduction; D011930:Reaction Time; D012886:Skull; D050781:Transcranial Magnetic Stimulation / Q000379:methods*