Localization of the gene encoding myelin basic protein to mouse chromosome 18E3----4 and rat chromosome 1p11----p12.
The location of a gene encoding myelin basic protein in rat (MBP) and mouse (Mbp) was determined by in situ hybridization using the mouse Mbp cDNA labeled with biotin-11-dUTP as a specific probe. The localization of biotin signals in the mouse was found on Chromosome 18E2----3. The result is consistent with the previous report that the Mbp gene is located on the distal half of Chromosome 18. In the rat, the signals localized on chromosome 1p11----p12, suggesting homology between mouse Chromosome 18 and the short arm of rat chromosome 1.
Koizumi
T
T
Institute for Experimental Animals, School of Medicine, Kanazawa University, Japan.
Katsuki
M
M
Kimura
M
M
Hayakawa
J
J
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D015342:DNA Probes; D005796:Genes; D051379:Mice / Q000235:genetics*; D004676:Myelin Basic Protein / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D051381:Rats / Q000235:genetics*
D015342:DNA Probes; D004676:Myelin Basic Protein