title: Lowering of pancreatic amylase activity induced by cold exposure, fasting and adrenalectomy in rats.
abstract: 1. Alteration of amylase activity in the pancreas was studied in rats under different stressful situations. 2. Cold-exposed rats had reduced amylase activity, hypertrophy of adrenal glands, and lowered plasma insulin and glucose. 3. In fasted rats, amylase activity decreased and plasma insulin and glucose lowered. 4. Immobilized animals failed to produce the reduced amylase activity, despite existence of higher plasma corticosterone. 5. Adrenalectomy caused reduction of amylase activity accompanied by decreases in plasma insulin and glucose. 6. Glucocorticoid hormone is not correlated with suppression of amylase synthesis. The lowered amylase activity might involve changes in glycolytic flux and/or suppression of amylase synthesis by insulin deficiency.
authors.affiliation: Department of Physiology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Harada
mesh_terms: D000311:Adrenal Glands / Q000254:growth & development / Q000473:pathology / Q000502:physiology; D000315:Adrenalectomy; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003080:Cold Temperature / Q000009:adverse effects; D005215:Fasting / Q000378:metabolism; D006984:Hypertrophy / Q000201:enzymology; D007328:Insulin / Q000097:blood; D008297:Male; D009929:Organ Size / Q000502:physiology; D010179:Pancreas / Q000201:enzymology* / Q000254:growth & development; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000201:enzymology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000681:Amylases