Human chorionic gonadotropin, its free subunits and gestational trophoblastic disease.
Monoclonal antibody-based immunoassays can detect specifically intact human chorionic gonadotropin (hCG), the free alpha-subunit and the free beta-subunit. The differential production of hCG and its free subunits is important in gestational trophoblastic disease. Using well-defined epitope-specific monoclonal antibodies in an immunoradiometric assay format, specific and sensitive assays have been developed. Serum levels of free beta-hCG were abnormally high in patients with gestational trophoblastic disease. In contrast, free alpha-hCG levels in serum were not increased.
Ozturk
M
M
Cancer Center, Massachusetts General Hospital, Boston 02129.
D000911:Antibodies, Monoclonal; D006063:Chorionic Gonadotropin / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015592:Immunoradiometric Assay / Q000592:standards; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D012680:Sensitivity and Specificity; D014328:Trophoblastic Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000235:genetics; D014594:Uterine Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000235:genetics
D000911:Antibodies, Monoclonal; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments