[The effect of enriched branched chain amino acid solution with hypocaloric TPN on acute phase protein, plasma amino acid profile metabolism in postoperative children].
From 1988 to 1990, 27 postoperative children with aganglionic megacolon were studied prospectively. They were randomly divided into three groups according to the postoperative fluid supply: group A, dextrose, group B, balanced amino acid solution (24% branch chain amino acid); and group C, solution enriched with branched chain amino acid (45% BCAA). The serum acute phase protein and plasma amino acid profile were observed. Nitrogen balance was monitored daily in all groups during the perioperative period. The data showed that prealbumin, transferrin rose more rapidly in group C than in group A and group B. The solution of 45% BCAA was found to be superior to balanced 24% BCAA in normalizing the disorder of plasma amino acid spectrum on the 3rd day and 7th day after operation. Urea nitrogen excretion was reduced in group C more rapidly than in group A and group B on the 4th day after operation. Using solution enriched branched chain amino acid with hypocaloric TPN in postoperative children can achieve an effective nitrogen sparing effect.
Xia
H M
HM
Tongji Hospiatal, Tongji Medical University, Wuhai.
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000596:Amino Acids / Q000097:blood*; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D002675:Child, Preschool; D002149:Energy Intake; D005260:Female; D006627:Hirschsprung Disease / Q000097:blood* / Q000601:surgery / Q000628:therapy; D006801:Humans; D008297:Male; D010289:Parenteral Nutrition, Total; D011184:Postoperative Period; D011446:Prospective Studies
D000209:Acute-Phase Proteins; D000596:Amino Acids; D000597:Amino Acids, Branched-Chain