title: Sudden arrhythmic death without overt heart disease.
abstract: Nine patients (eight males) are reported with one or more episodes of circulatory collapse in the absence of overt heart disease or other known causes of arrhythmias; sudden arrhythmic death occurred in one of these patients. Age at first episode ranged from 16 to 41 (mean, 28) years. In seven patients, ventricular fibrillation was documented at the time of resuscitation. One patient had ventricular flutter. In the remaining patient, documentation of the arrhythmia during the collapse was not available. Four patients had frequent early ventricular premature beats, and in three of these patients, they were accompanied by episodes of rapid nonsustained polymorphic ventricular tachycardia. Failure to suppress this ectopic activity by drug therapy seems to be of prognostic significance. Of the three patients showing persistence of frequent early ventricular premature beats, one died suddenly, and two had recurrences of symptomatic arrhythmic episodes. The value of noninvasive and invasive tests in the management of these patients is not clear, with the exception of exercise testing in patients with exercise-related arrhythmias and long-term electrocardiographic monitoring in patients with frequent spontaneous ventricular ectopic activity. Follow-up varied from 21 to 192 (mean, 84) months. One patient died suddenly 21 months after his first collapse. Selection of antiarrhythmic drug therapy was largely empirical. In view of the relative rarity of sudden arrhythmic death in the absence of heart disease and the many uncertainties about its mechanism(s) and management, a worldwide registry of these patients is suggested.
authors.affiliation: Department of Cardiology, Academic Hospital Maastricht, University of Limburg, Maastricht, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Wellens
authors.forename: R
authors.initials: R
authors.lastname: Lemery
authors.forename: J L
authors.initials: JL
authors.lastname: Smeets
authors.forename: P
authors.initials: P
authors.lastname: Brugada
authors.forename: A P
authors.initials: AP
authors.lastname: Gorgels
authors.forename: E C
authors.initials: EC
authors.lastname: Cheriex
authors.forename: C
authors.initials: C
authors.lastname: de Zwaan
mesh_terms: D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D002304:Cardiac Pacing, Artificial; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male
chemical_list: D000889:Anti-Arrhythmia Agents