Protective effect of liposome-entrapped superoxide dismutase and catalase on bleomycin-induced lung injury in rats. II. Phospholipids of the lung surfactant.
The influence of liposome-entrapped catalase and/or superoxide dismutase on phospholipids of the lung surfactant in bleomycin-treated rats was investigated. Changes in phospholipid composition of lung surfactant were much pronounced in animals supplemented with antioxidant enzymes-loaded liposomes. It is suggested that liposomes are good carriers for drugs in bleomycin-induced lung injury treatment.
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Department of Pathophysiology, Veterinary Faculty, Agricultural Academy, Lublin, Poland.
D000818:Animals; D001761:Bleomycin; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002374:Catalase / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D004337:Drug Carriers; D008081:Liposomes; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D011663:Pulmonary Surfactants / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000494:pharmacology*
D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D011663:Pulmonary Surfactants; D001761:Bleomycin; D002374:Catalase; D013482:Superoxide Dismutase