title: Immunohistochemical demonstration of insulin-like growth factor I (IGF-1) in normal and pathological human pituitary glands.
abstract: The authors have studied the presence and distribution of Insulin-Like-Growth-Factor-1 (IGF-1) in 5 autopsied normal and 20 surgically removed human pituitary adenomas, employing a peroxidase-anti-peroxidase method. IGF-1 could be demonstrated in all cases, with variation of cells immunostaining from 60% in normal pituitary gland to 100% in corticotroph cell adenoma.
authors.affiliation: Department of Pathology, Escola Paulista de Medicina, São Paulo, Brazil.
authors.forename: V N
authors.initials: VN
authors.lastname: Alberti
authors.forename: L C
authors.initials: LC
authors.lastname: Takita
authors.forename: M I
authors.initials: MI
authors.lastname: de Mesquita
authors.forename: S
authors.initials: S
authors.lastname: Percário
authors.forename: R M
authors.initials: RM
authors.lastname: Maciel
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism*; D012016:Reference Values; D013194:Staining and Labeling
chemical_list: D007334:Insulin-Like Growth Factor I