title: Detection of 2',5' oligoadenylate synthetase activity in acute viral hepatitis with special reference to histologic features in the acute stage.
abstract: We measured the sequential changes in 2',5' oligoadenylate synthetase activity in 21 patients with acute viral hepatitis (5 with type A, 6 with type B, and 10 with type non-A, non-B hepatitis) by radioimmunoassay. Liver biopsies were performed during the acute phase in all patients. Among patients with acute hepatitis A and B, the 2',5' oligoadenylate synthetase levels were transiently elevated at the time of the peak alanine aminotransferase level in the patients in whom a liver biopsy showed acute hepatitis or non-specific reactive hepatitis. Of 10 patients with acute non-A, non-B hepatitis, 4 showed a similar 2',5' oligoadenylate synthetase activity pattern and liver histology to those observed in acute hepatitis A and B. In the remaining 6, the 2',5' oligoadenylate synthetase levels remained elevated for 3.5 to 6 months while the alanine aminotransferase was elevated. Liver biopsy in these patients showed chronic hepatitis. Persistent detection of raised 2',5' oligoadenylate synthetase activity levels during the acute stage of non-A, non-B hepatitis may thus be an indicator of progression of the disease.
authors.affiliation: Department of Internal Medicine, Akashi Municipal Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: M
authors.initials: M
authors.lastname: Shindo
authors.forename: K
authors.initials: K
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Kashima
authors.forename: Y
authors.initials: Y
authors.lastname: Sokawa
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000097:blood*; D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001706:Biopsy; D005260:Female; D006506:Hepatitis A / Q000201:enzymology / Q000473:pathology; D006509:Hepatitis B / Q000201:enzymology / Q000473:pathology; D006526:Hepatitis C / Q000201:enzymology / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007372:Interferons / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D007372:Interferons; D000410:Alanine Transaminase; D015088:2',5'-Oligoadenylate Synthetase