Vascular responses to histamine at low temperatures in normal digital skin and Raynaud's phenomenon.
A defective histaminergic dilating system in the digital vasculature has been proposed for the pathophysiology of Raynaud's phenomenon but this is not supported by studies of digital intradermal responses to histamine or agents which cause histamine release. The vascular responses (measured by planimetry and laser Doppler flowmetry) of digital skin over the middle phalanx to intradermal histamine, compound 48/80 and Substance P have now been studied at low temperatures (because it is in the cold that Raynaud's phenomenon occurs) in normal controls and patients with primary Raynaud's phenomenon. A cold-related attenuation of mast cell histamine release by compound 48/80 was observed in both normal and Raynaud's subjects. These results do not support a major histaminergic defect in the pathogenesis of Raynaud's phenomenon.
Bunker
C B
CB
Department of Dermatology, University College and Middlesex School of Medicine, London, UK.
Foreman
J C
JC
Dowd
P M
PM
D000328:Adult; D003080:Cold Temperature; D005260:Female; D005385:Fingers; D006632:Histamine / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D011928:Raynaud Disease / Q000503:physiopathology*; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D013373:Substance P / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D013373:Substance P; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine