Effect of substance P on the membrane potential of coronary arterial endothelial cells in situ.
The membrane potential of the endothelial cells on a strip of pig coronary artery was recorded. The fluorescent dye lucifer yellow was injected into the recorded cell in order to prove its identity. We show that substance P transiently hyperpolarized these cells. The function of the endothelial cell hyperpolarization could be important for the role played by the endothelium and the kinins in inflammation.
Bény
J L
JL
Département de Zoologie et Biologie Animale, Université de Genéve, Switzerland.
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005456:Fluorescent Dyes; D007546:Isoquinolines; D008564:Membrane Potentials / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*; D013552:Swine
D005456:Fluorescent Dyes; D007546:Isoquinolines; D013373:Substance P; C017475:lucifer yellow