Complete remission of metastatic teratoma from malignant testicular tumor using salvage chemotherapy with VP-16 (etoposide), CDDP, and ACNU--case report.
A 26-year-old male with an intracranial teratoma, metastasizing from a testicular yolk sac tumor refractory to cis-diamminedichloroplatinum (CDDP), vinblastin, and bleomycin (PVB) therapy, was successfully treated with a combination of etoposide (VP-16), CDDP, and ACNU (salvage chemotherapy). Emergency surgery for subcortical hemorrhage discovered the metastasis, diagnosed as a yolk sac tumor. CDDP chemotherapy failed to prevent recurrence, and total removal was impossible due to subdural invasion. He underwent radiation therapy and salvage chemotherapy. A third operation found only scar tissue. Maintenance salvage chemotherapy was continued. He was doing well 30 months after the first operation.
Suwa
H
H
Department of Neurosurgery, Shizuoka Prefectural General Hospital.
Hanakita
J
J
Nishi
S
S
Nishihara
K
K
Ohta
F
F
Sakaida
H
H
Iihara
K
K
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D008297:Male; D015376:Nimustine / Q000008:administration & dosage; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D012074:Remission Induction; D016879:Salvage Therapy; D013724:Teratoma / Q000188:drug therapy* / Q000556:secondary*; D013736:Testicular Neoplasms / Q000473:pathology*
D009944:Organoplatinum Compounds; D015376:Nimustine; C055423:didimethylsulfoxide dichloroplatinum(II); D005047:Etoposide