Neuron regeneration reverses 3-acetylpyridine-induced cell loss in the cerebral cortex of adult lizards.
Systemic administration of the neurotoxin 3-acetylpyridine to adult lizards results in extensive loss of neurons in the medial cerebral cortex, other brain areas remaining largely unaffected. After the neurotoxic trauma, new cells are produced by mitotic division of cells in the ventricular wall. The new cells migrate along radial glial fibers and replace lost neurons in the medial cortex. Electron microscopic examination of cells labeled with [3H]thymidine confirms that the newly generated cells are neurons. Thus, neuron regeneration can occur in the cerebral cortex of adult lizards.
Font
E
E
Cátedra de Citología e Histología, Facultad de Ciencias Biológicas,Universidad de Valencia, Burjassot, Spain.
García-Verdugo
J M
JM
Alcántara
S
S
López-García
C
C
D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002455:Cell Division; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D008116:Lizards / Q000502:physiology*; D008297:Male; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D011725:Pyridines / Q000494:pharmacology*; D013194:Staining and Labeling; D013997:Time Factors
D011725:Pyridines; C010835:3-acetylpyridine