title: Carcinoma of prostate in men aged fifty and under: therapeutic options.
abstract: We made a retrospective study of 20 men, aged fifty or under, with adenocarcinoma of the prostate to evaluate presenting symptoms, stage, grade, and therapeutic results. Sixty-five percent were found to have extracapsular spread of disease (Stage C or D). The therapy used was one or a combination of three types: radical prostatectomy, radiation therapy, and hormonal manipulation. Five of 6 patients with Stage B disease and 3 of 6 patients with Stage C disease were treated with radiation therapy. The other Stages B and C patients underwent radical prostatectomy. In all 5 of Stage B patients receiving radiation, therapy failed; the mean time to tumor recurrence was 3.2 years. Two of 3 patients with Stage C disease died of metastatic disease within three years of receiving radiation. The 4 patients (Stages B and C) who underwent radical prostatectomy are free of disease. There was a statistically higher failure rate among the radiation therapy patients with Stages B and C disease than among the surgical patients (X2 = 8.4, p less than 0.1).
authors.affiliation: Hahnemann University, Philadelphia, Pennsylvania.
authors.forename: P
authors.initials: P
authors.lastname: Werthman
authors.forename: O P
authors.initials: OP
authors.lastname: Khanna
authors.forename: P
authors.initials: P
authors.lastname: Gonick
authors.forename: L
authors.initials: L
authors.lastname: Silverstein
authors.forename: A E
authors.initials: AE
authors.lastname: Fetzer
authors.forename: J S
authors.initials: JS
authors.lastname: Jaffe
authors.forename: R
authors.initials: R
authors.lastname: Dilcher
authors.forename: E
authors.initials: E
authors.lastname: Mullin
authors.forename: R
authors.initials: R
authors.lastname: Wasko
authors.forename: D M
authors.initials: DM
authors.lastname: Nugent
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000628:therapy*; D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome