title: The influence of mechanical injury on the metabolic activity of transplanted cerebral cortex.
abstract: The authors studied the metabolic activity of rat embryonic cerebral cortex grafts (ED 15-16) implanted into rat brains immediately (TR0) and 14 days (TR14) after cavity formation. Over a period of two months, the ATP, lactate and glucose concentration in TR0 transplants remained at the same level as observed in the intact cortex, whereas in TR14 transplants the ATP and glucose concentration fell significantly and the lactate concentration rose. The DNA concentration rose in both types of transplants, but the increase was more pronounced in TR0 grafts. Choline acetyltransferase activity (a neuron marker) fell significantly in both cases, but the decrease was greater in TR14 transplants. The results indicate that grafts implanted into the brain immediately after cavities had been formed have better metabolic activity and are capable of longer survival than grafts implanted 14 days after cavitation.
authors.affiliation: Institute of Neurobiology, Slovak Academy of Sciences, Kosice.
authors.forename: D
authors.initials: D
authors.lastname: Kluchová
authors.forename: V
authors.initials: V
authors.lastname: Danielisová
authors.forename: Z
authors.initials: Z
authors.lastname: Malátová
authors.forename: J
authors.initials: J
authors.lastname: Martiniak
authors.forename: M
authors.initials: M
authors.lastname: Gottlieb
authors.forename: V
authors.initials: V
authors.lastname: Valousková
authors.forename: M
authors.initials: M
authors.lastname: Chavko
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000196:embryology / Q000293:injuries / Q000378:metabolism / Q000637:transplantation*; D004247:DNA / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats
chemical_list: D000596:Amino Acids; D007773:Lactates; D010725:Phosphocreatine; D012313:RNA; D000255:Adenosine Triphosphate; D004247:DNA; D005947:Glucose; D000109:Acetylcholine