Cytokeratin expression in a congenital multipotential primitive neuroectodermal tumor.
A case of an uncommon congenital primitive neuroectodermal cerebellar tumor (PNET) in a 5-month-old child is reported. After subtotal surgical resection, the residual tumor did not respond to radiation and chemotherapy. Histologically, the tumor was composed of small, round, undifferentiated cells and several other patterns like astrocytomatous, oligodendrogliomatous, and ependymomatous structures. Immunostaining was positive for most of the cells for vimentin and S 100, fewer were positive for glial fibrillary acid protein (GFAP) and neuron-specific enolase, and only a few for synaptophysin. Surprisingly, the tumor showed strong expression of several monoclonal cytokeratins (CK) with different molecular weights, together with epithelial membrane antigen. Furthermore, we found a coexpression of the tumor cells for CK and vimentin, while CK-GFAP and CK-S 100 were negative. Ultrastructurally, intracytoplasmic intermediate filaments could be observed corresponding to immunohistochemical CK expression. The very strong CK and vimentin expression in this case was interpreted as a sign of the embryonic nature of the tumor.
Zimmer
C
C
Institut für Neuropathologie, Freien Universität, Berlin, Federal Republic of Germany.
Figols
J
J
Patt
S
S
Cervos-Navarro
J
J
D014408:Biomarkers, Tumor / Q000032:analysis*; D002528:Cerebellar Neoplasms / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007223:Infant; D007633:Keratins / Q000032:analysis*; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; D005904:Glial Fibrillary Acidic Protein; D014746:Vimentin; D007633:Keratins; D010751:Phosphopyruvate Hydratase