title: Comparison of the effects of sodium pentosanpolysulfate and unfractionated heparin on venous thrombosis; an experimental study in rats.
abstract: Sodium pentosanpolysulfate (Fibrezym) and unfractionated heparin (Liquemin) had significant antithrombotic efficacy in rats. 1 mg/kg body weight (BW) FibrezymR had its maximal effect 2-4 hours after subcutaneous administration; 200 U/kg BW LiqueminR s.c. were most effective 4-6 hours after application. Both drugs caused frequent embolic break-offs of thrombi during the time periods of maximal antithrombotic efficiency.
authors.affiliation: Department of Clinical Hemostaseologie and Transfusion Medicin, University Homburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kiesel
authors.forename: G
authors.initials: G
authors.lastname: Harbauer
authors.forename: E
authors.initials: E
authors.lastname: Wenzel
authors.forename: G
authors.initials: G
authors.lastname: Pindur
authors.forename: S
authors.initials: S
authors.lastname: Bohnerth
mesh_terms: D000818:Animals; D004617:Embolism; D006493:Heparin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013924:Thrombophlebitis / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D010426:Pentosan Sulfuric Polyester; D006493:Heparin