title: Interleukin-6 stimulates proliferation of cultured vascular smooth muscle cells independently of interleukin-1 beta.
abstract: The effects of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) on proliferation of cultured vascular smooth muscle cells (VSMCs) were investigated. Treatment with IL-6 caused a rapid increase in the c-myc mRNA level, and resulted in increases in DNA synthesis and cell number. IL-1 beta stimulated the DNA synthesis of the cells. EGF showed synergistic and PDGF or IL-1 beta showed additive effects with IL-6 on the DNA synthesis. These results suggest that IL-6, independently of IL-1 beta, may be important in the proliferation of VSMCs.
authors.affiliation: Department of Geriatric Medicine, Osaka University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Nabata
authors.forename: E
authors.initials: E
authors.lastname: Koh
authors.forename: T
authors.initials: T
authors.lastname: Shiraishi
authors.forename: K
authors.initials: K
authors.lastname: Fukuo
authors.forename: S
authors.initials: S
authors.lastname: Imanaka
authors.forename: S
authors.initials: S
authors.lastname: Kitano
authors.forename: Y
authors.initials: Y
authors.lastname: Miyashita
authors.forename: T
authors.initials: T
authors.lastname: Ogihara
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D004247:DNA