title: Gangliosides, copper ions and angiogenic capacity of adult tissues.
abstract: The report summarizes the work of our laboratory aimed at improving the understanding of the angiogenic response of adult tissues, an event that transforms a micro-embolus of neoplastic cells into a growing metastasis. Attention has been focused on tumor-induced angiogenesis. The following aspects of the subject are discussed: (a) relationship between size of vascular network and tumor growth rate or tumor cell population; (b) angiogenic capacity of tumors and role that prostaglandin E1 may have as an angiogenesis factor; (c) relationship between acquisition of angiogenic capacity and neoplastic transformation of a cell population; (d) modification of tissue composition at the onset of angiogenesis; (e) behaviour of copper ions and copper carriers in the course of the angiogenic response; (f) the influence of gangliosides on endothelial cell motility, survival and growth in vitro; (g) modulation of the angiogenic response by gangliosides (GM1, GT1b) in vivo.
authors.affiliation: Department of Biomedical Sciences, University of Turin, Italy.
authors.forename: P M
authors.initials: PM
authors.lastname: Gullino
authors.forename: M
authors.initials: M
authors.lastname: Ziche
authors.forename: G
authors.initials: G
authors.lastname: Alessandri
mesh_terms: D000527:Alprostadil / Q000502:physiology; D000818:Animals; D003300:Copper / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D005732:Gangliosides / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology*
chemical_list: D005732:Gangliosides; D003300:Copper; D000527:Alprostadil