Hemopoiesis stimulating and radioprotective effects of carboxymethylglucan.
Carboxymethylglucan, a novel soluble derivative of beta-1,3-glucan, was found to enhance hemopoietic recovery in sublethally gamma-irradiated mice and to increase survival in lethally irradiated animals when given 24 hours prior to irradiation. Postirradiation treatment with carboxymethylglucan also induced favourable effects in terms of survival when used in combination with preirradiation cystamine administration.
Pospísil
M
M
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Sandula
J
J
Pipalová
I
I
Hofer
M
M
Viklická
S
S
D000818:Animals; D003911:Dextrans / Q000494:pharmacology*; D005720:Gamma Rays; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D003911:Dextrans; D011837:Radiation-Protective Agents; C014392:carboxymethyl dextran