Management of a severe transfusional problem in a patient with alloantibody to Kpb (K4).
The case of a 58-year-old male with severe anemia after hemicolectomy is described. The patient proved to be Kp(b-), and the serum contained anti-Kpb. Because no Kp(b-) donors were available, two incompatible units are administered after intravenous gammaglobulin (400 mg/kg/day) and hydrocortisone (500 mg). The tolerance was good, without signs of increased red cell destruction. Pending the arrival of compatible blood from the American Red Cross, the hematocrit reached 18%, and the direct antiglobulin test remained negative.
Kohan
A I
AI
Departamento de Hemoterapia e Inmunohematología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina.
Reybaud
J F
JF
Salamone
H J
HJ
Rey
J A
JA
Rey
C E
CE
Villaravid
N
N
Papa
S
S
Cyrulik Goldztein
S
S
Calahonra
R
R
Sanchez Avalos
J C
JC
D001787:Blood Group Incompatibility / Q000517:prevention & control*; D001803:Blood Transfusion / Q000379:methods*; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D007518:Isoantibodies / Q000302:isolation & purification*; D007626:Kell Blood-Group System / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D065227:Transfusion Reaction; D005719:gamma-Globulins / Q000627:therapeutic use
D007518:Isoantibodies; D007626:Kell Blood-Group System; D005719:gamma-Globulins; D006854:Hydrocortisone