title: Enkephalin, dynorphin and substance P in postmortem substantia nigra from normals and schizophrenic patients.
abstract: Three peptide neuromodulators that are found in high concentration in the substantia nigra: dynorphin A 1-8, met5-enkephalin-arg6-gly7-leu8 and substance P, were measured by specific radioimmunoassays in nigral tissue from normals and schizophrenics postmortem. Substance P and dynorphin were unchanged between the two groups. However, the proenkephalin-derived peptide was significantly elevated in the schizophrenic group. The immunoreactivity was identified as authentic met5-enkephalin-arg6-gly7-leu8 by high pressure liquid chromatography. The data suggest that a different set of regulatory controls exists for nigral enkephalin peptides as compared to dynorphin and substance P, and that the former system may be disordered in schizophrenia.
authors.affiliation: Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892.
authors.forename: M J
authors.initials: MJ
authors.lastname: Iadarola
authors.forename: D
authors.initials: D
authors.lastname: Ofri
authors.forename: J E
authors.initials: JE
authors.lastname: Kleinman
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D004399:Dynorphins / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism*; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; D013373:Substance P; D004744:Enkephalin, Methionine; D004399:Dynorphins; C026770:dynorphin (1-8); C033453:enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-