title: Facile cleavage of RNA via phosphodiester linkage fission by Co(III) complex.
abstract: Adenylyl (3'-5')adenosine (ApA) is effectively cleaved to two adenosine molecules by [Co(trien)(H2O)2]3+ complex (trien: triethylenetetramine). The complex (0.20 M) accelerates the cleavage by 10(5) fold, decreasing half-life of ApA from 4000 years to 9.3 days. The reaction involves general base catalysis by the hydroxide ion bound to the Co(III) ion for the formation of adenosine 2',3'-cyclic phosphate (A greater than p), followed by the prompt cleavage of the intermediate to adenosine.
authors.affiliation: Institute of Materials Science, University of Tsukuba, Ibaraki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Yonezawa
authors.forename: M
authors.initials: M
authors.lastname: Komiyama
mesh_terms: D015226:Dinucleoside Phosphates / Q000378:metabolism*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000494:pharmacology*; D012313:RNA / Q000187:drug effects* / Q000378:metabolism; D014266:Trientine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D015226:Dinucleoside Phosphates; D009942:Organometallic Compounds; C070281:cobalt triethylene tetramine complex; C006412:adenylyl-(3'-5')-adenosine; D012313:RNA; D014266:Trientine