[Expression of latent membrane proteins (LMP) of Epstein-Barr virus in malignant lymphomas].
The presence of Epstein-Barr virus (EBV) DNA and antigens was assessed by polymerase chain reaction and immunohistology, respectively, in a total of 92 cases of Hodgkin's disease, angioimmunoblastic lymphadenopathy, CD30-positive anaplastic large cell (ALC) lymphomas, and AIDS-associated atypical lymphoproliferations (ALP). Proportions of the EBV DNA-positive lesions showed latent membrane protein (LMP) expression; some of the LMP-positive ALC lymphomas and ALP cases also displayed EBNA2 immunostaining. BZLF1-protein and gp250/350 immunoreactivity were absent in all instances indicating latent EBV infection. Since the LMP gene has transforming potential, our findings support the concept of a pathoetiological role for EBV in these lymphoproliferative lesions.
Herbst
H
H
Institut für Pathologie, Klinikum Steglitz, Berlin.
Dallenbach
F
F
Niedobitek
G
G
Anagnostopoulos
I
I
Hummel
M
M
Finn
T
T
Jautzke
G
G
Müller-Lantzsch
N
N
Stein
H
H
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology; D000956:Antigens, Viral / Q000032:analysis*; D002051:Burkitt Lymphoma / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000382:microbiology* / Q000473:pathology; D014764:Viral Proteins / Q000032:analysis*
D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins
Expression des latenten Membranproteins (LMP) des Epstein-Barr-Virus in malignen Lymphomen.