[Pathogenesis of amyloidosis: a role for anti-proteases?].
A new type of amyloidosis has been observed which appears in long-term survivors on haemodialysis, with beta 2-microglobulin identified as its major protein constituent. We recently identified alpha 2-macroglobulin, the major serum anti-protease, in amyloid deposits of haemodialysis patients. It has also been reported that amyloid fibrils can be redissolved in vitro by proteases. These findings, coupled with the facts that alpha 2-macroglobulin blocks the proteases and decreases macrophage production of proteases, suggest that alpha 2-macroglobulin may prevent the degradation of the amyloidogenic protein allowing amyloid deposit formation and/or persistence. In our opinion, alpha 2-macroglobulin and possibly other antiproteases as well, may play a key role in amyloidogenesis in dialysis patients.
Argilés i Ciscart
A
A
Department of Nephrology, Prince Henry's Hospital, Monash University, Melbourne, Australia.
Mourad
G
G
D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000201:enzymology / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D008954:Models, Biological; D010446:Peptide Fragments / Q000032:analysis; D011487:Protein Conformation; D006435:Renal Dialysis / Q000009:adverse effects*; D000511:alpha-Macroglobulins / Q000302:isolation & purification / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D000682:Amyloid; D010446:Peptide Fragments; D000511:alpha-Macroglobulins; D001613:beta 2-Microglobulin
Pathogénie de l'amylose: un rôle pour les anti-protéases?