Oxygen-exacerbated bleomycin pulmonary toxicity.
Bleomycin is an antineoplastic agent with potential for producing pulmonary toxicity, attributed in part to its free radical-promoting ability. Clinical and research experiences have suggested that the risk of bleomycin-induced pulmonary injury is increased with the administration of oxygen. We report a case in which the intraoperative administration of oxygen in the setting of previous bleomycin therapy contributed to postoperative ventilatory failure. Our patient recovered with corticosteroid therapy. Physician awareness of a potential interaction between oxygen and bleomycin may help reduce the morbidity and mortality related to bleomycin therapy.
Ingrassia
T S
TS
Division of Thoracic Diseases, Mayo Clinic, Rochester, MN 55905.
Ryu
J H
JH
Trastek
V F
VF
Rosenow
E C
EC
D000208:Acute Disease; D000328:Adult; D001761:Bleomycin / Q000009:adverse effects*; D004357:Drug Synergism; D006801:Humans; D007430:Intraoperative Care; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects*; D012086:Reoperation; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*
D001761:Bleomycin