[Determination of elastase and alpha 2-macroglobulin in bronchoalveolar lavage fluid in patients with interstitial diseases and its clinical significance].
Determination of elastase and its inhibitor alpha 2-Macroglobulin was done in BALF in 40 patients with ILD (study group) and 10 healthy volunteers (control group). The results showed that BALF levels of elastase and alpha 2-macroglobulin in study group were significantly higher than those in control group (P less than 0.01; P less than 0.05). Correlation was found between BALF elastase levels and cell count (r = 0.3214, P less than 0.05). It was suggested that elastase may play a role in the development of pulmonary fibrosis in interstitial lung diseases.
Li
Z H
ZH
Institute of Respiratory Disease, China Medical University.
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010196:Pancreatic Elastase / Q000032:analysis*; D011658:Pulmonary Fibrosis / Q000378:metabolism*; D000511:alpha-Macroglobulins / Q000032:analysis*
D000511:alpha-Macroglobulins; D010196:Pancreatic Elastase