Modulation of humoral immune responses by Tinospora malabarica in experimental animals.
Effect of alkaloidal fraction of aqueous extract of T. malabarica (Tm) was studied on humoral antibody responses in rats and guineapigs. The anti-SRBC haemagglutination titre was found to be enhanced in rats pretreated with Tm (2.5 mg/kg). Passive cutaneous anaphylaxis (PCA) in rats was also increased in Tm treated group. In vitro experiments with sensitized rat peritoneal mast cells showed a significant decrease in antigen-induced various spasmogens on isolated guineapig ileum.
Bhattacharya
S K
SK
Department of Pharmacology, University College of Medical Sciences & GT Hospital, Delhi, India.
Maity
P C
PC
Mediratta
P
P
Sen
P
P
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006384:Hemagglutination / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats
D010936:Plant Extracts