title: Genomic organization and alternative promoter usage of the two thyroid hormone receptor beta genes in Xenopus laevis.
abstract: Each of the two Xenopus laevis thyroid hormone receptor beta genes is at least 70 kilobases in length with similar intron-exon organization. There are up to eight alternatively spliced exons in the 5'-untranslated region. Excluding the extreme amino terminus, each receptor is encoded by six exons spanning about 6 kilobases of the genome, in which each of the two zinc fingers that comprise the DNA-binding domain is encoded by a separate exon and the hormone-binding domain is split into three exons. The last exon of the coding region also contains at least 600 base pairs of the 3'-untranslated region, which is about 8 kilobases. Each of the receptor genes has two promoters and just one of them is up-regulated in tadpoles by the administration of thyroid hormone.
authors.affiliation: Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210.
authors.forename: Y B
authors.initials: YB
authors.lastname: Shi
authors.forename: Y
authors.initials: Y
authors.lastname: Yaoita
authors.forename: D D
authors.initials: DD
authors.lastname: Brown
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005091:Exons; D007438:Introns; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics; D011988:Receptors, Thyroid Hormone / Q000235:genetics*; D014158:Transcription, Genetic; D015854:Up-Regulation; D014982:Xenopus laevis / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D011988:Receptors, Thyroid Hormone