Prolactin-dependent seasonal changes in pelage: role of the pineal gland and dopamine.
The Siberian hamster displays seasonal changes in pelage that are dependent upon fluctuations in circulating prolactin levels. Pinealectomy prevented the decrease in serum prolactin and molt to the winter pelage displayed by castrated males housed under a short-day photoperiod. A dopaminergic antagonist, pimozide, enhanced prolactin levels in both pinealectomized and sham-operated animals under both long and short photoperiods. In the short-day animals, this effect of pimozide was associated with a prevention of the development of winter pelage. These results indicate that seasonal prolactin levels and related pelage changes are dependent upon the integrity of the pineal gland. However, basal prolactin levels under different photoperiod conditions appear to be only partly regulated by the actions of the dopaminergic system.
Badura
L L
LL
Department of Physiology and Neurobiology, University of Connecticut, Storrs 06269.
Goldman
B D
BD
D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D001971:Bromocriptine / Q000494:pharmacology; D006224:Cricetinae; D004298:Dopamine / Q000502:physiology*; D006197:Hair / Q000502:physiology*; D006200:Hair Color / Q000187:drug effects / Q000502:physiology; D008027:Light; D008297:Male; D010868:Pimozide / Q000494:pharmacology; D010870:Pineal Gland / Q000502:physiology* / Q000601:surgery; D011388:Prolactin / Q000097:blood / Q000502:physiology*; D012621:Seasons
D010868:Pimozide; D001971:Bromocriptine; D011388:Prolactin; D004298:Dopamine