In vitro neutralization of Chlamydia trachomatis by monovalent Fab antibody specific to the major outer membrane protein.
Monovalent Fab antibodies to serovar- and subspecies-specific epitopes of the major outer membrane protein (MOMP) of Chlamydia trachomatis neutralized infectivity for hamster kidney cells by preventing chlamydial attachment. These findings exclude the aggregation of chlamydiae as a mechanism of anti-MOMP neutralization and provide additional evidence in support of the MOMP as a chlamydial adhesin.
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Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840.
Caldwell
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D000595:Amino Acid Sequence; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D000918:Antibody Specificity; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D002460:Cell Line; D002692:Chlamydia trachomatis / Q000276:immunology*; D006224:Cricetinae; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D008969:Molecular Sequence Data; D009500:Neutralization Tests
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D000939:Epitopes; D007140:Immunoglobulin Fab Fragments