[An immunochemical analysis of the function of the hemato-encephalic barrier in acute fetal hypoxia and asphyxia neonatorum].
The neurospecific protein alpha 1-globulin has been assayed in serum in order to evaluate the blood-brain barrier in newborns with acute intrapartum hypoxia. The study involved 35 term newborns with birth asphyxia of variable severity. The alpha 1-globulin levels correlated with severity of condition at birth, duration of intrauterine exposure to hypoxia and the presence of obstetric complications and clinical severity of cerebral circulatory disorders. A normal early adaptation and effective therapy reduced serum alpha 1-globulin levels 4-8-fold on the 3rd postnatal day and 6-16-fold on the 5th day. Deterioration of neurological symptoms was parallelled by a significant increase in protein levels (to 6400 ng/ml) at day 5. This evidence may confirm the fact that permeability of the blood-brain barrier is impaired by intrapartum hypoxia.
Savel'eva
G M
GM
Chekhonin
V P
VP
Pavlova
T A
TA
Kushch
I B
IB
Shalina
R I
RI
Rogatkin
S O
SO
Morozov
S G
SG
Volodin
N N
NN
D000208:Acute Disease; D000510:Alpha-Globulins / Q000032:analysis; D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D001812:Blood-Brain Barrier / Q000276:immunology*; D002560:Cerebrovascular Circulation; D005260:Female; D005311:Fetal Hypoxia / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007120:Immunochemistry; D007231:Infant, Newborn; D011247:Pregnancy; D014593:Uterine Inertia / Q000150:complications
D000510:Alpha-Globulins
Immunokhimicheskiĭ analiz sostoianiia gematoéntsefalicheskogo bar'era pri ostroĭ gipoksii plodov i asfiksii novorozhdennykh.