title: A lectin-binding soluble factor released by CD8+CD57+ lymphocytes from AIDS patients inhibits T cell cytotoxicity.
abstract: CD8+CD57+ T cells, expanded in peripheral blood lymphocytes of AIDS patients, inhibit the effector phase of HLA-specific cytotoxic T lymphocytes, natural killer and lymphocyte-activated killer cells in a 4-h chromium-release assay. This inhibitory activity present in supernatants of purified sorted CD8+CD57+ cells is mediated by a non-antigen-specific inhibitory factor which is distinct from prostaglandin E2, T cell growth factor (TGF)-beta, latent-TGF-beta, tumor necrosis factor (TNF)-alpha and TNF-beta. Partial biochemical characterization demonstrates that the CD8+CD57+ inhibitory activity (a) is heat, trypsin and acid resistant, (b) binds to concanavalin A columns, indicating its glycosylation state and (c) is mediated by a 20-30-kDa soluble molecule.
authors.affiliation: Laboratoire d'Immunologie Cellulaire et Tissulaire, CNRS UA 0186, CHU Pitié-Salpétrière, Paris.
authors.forename: B
authors.initials: B
authors.lastname: Sadat-Sowti
authors.forename: P
authors.initials: P
authors.lastname: Debré
authors.forename: T
authors.initials: T
authors.lastname: Idziorek
authors.forename: J M
authors.initials: JM
authors.lastname: Guillon
authors.forename: F
authors.initials: F
authors.lastname: Hadida
authors.forename: E
authors.initials: E
authors.lastname: Okzenhendler
authors.forename: C
authors.initials: C
authors.lastname: Katlama
authors.forename: C
authors.initials: C
authors.lastname: Mayaud
authors.forename: B
authors.initials: B
authors.lastname: Autran
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D018959:CD57 Antigens; D016827:CD8 Antigens; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D037102:Lectins / Q000378:metabolism; D008970:Molecular Weight; D012995:Solubility; D013491:Suppressor Factors, Immunologic / Q000737:chemistry / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D018959:CD57 Antigens; D016827:CD8 Antigens; D037102:Lectins; D013491:Suppressor Factors, Immunologic