[An experimental study on the pathogenesis of pulmonary edema in acute pancreatitis, with special interest to the effects of colloid infusion and the role of endotoxin].
This experimental study was undertaken to clarify the role of pancreatic enzymes and endotoxin in the pathogenesis of pulmonary edema in acute pancreatitis, paying special attention to the effects of two different intravenous infusions: lactated Ringer's solution (LR) and Dextran 40 (D40). After acute pancreatitis was induced in dogs by injecting autologous gallbladder bile into the main pancreatic duct, plasma endotoxin levels increased markedly in both the LR and D40 groups, and PaO2 decreased more significantly in the D40 group. Extravascular lung water (EVLW) increased more significantly in the D40 group than in the LR group, in spite of the fact that colloid-hydrostatic pressure gradient (CHPG) had been maintained more efficiently in the D40 group. Significant correlation between EVLW and plasma endotoxin level was delineated in both groups, but the slope of the regression line in the D40 group was much greater than that of the LR group. Infusion of trypsin and elastase into the pulmonary artery in normal dogs caused moderate elevation of EVLW in the D40 group, but there was no significant alteration in the LR group. The changes of PaO2, EVLW, and CHPG after infusion of endotoxin were similar to those in the animals with experimental acute pancreatitis. In conclusion, endotoxin appears to play an important role in the pathogenesis of pancreatitis-induced pulmonary edema by causing an increase in pulmonary vascular permeability, and under these circumstances the infusion of large amount of colloid solution promotes the development of pulmonary edema.
Hirota
T
T
First Department of Surgery, Mie University School of Medicine, Japan.
D000208:Acute Disease; D000818:Animals; D003102:Colloids; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects*; D004285:Dogs; D004731:Endotoxins / Q000502:physiology*; D015633:Extravascular Lung Water / Q000378:metabolism; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000009:adverse effects*; D010195:Pancreatitis / Q000150:complications*; D011654:Pulmonary Edema / Q000209:etiology* / Q000378:metabolism; D012044:Regression Analysis; D000077325:Ringer's Lactate
D003102:Colloids; D003911:Dextrans; D004731:Endotoxins; D007552:Isotonic Solutions; D000077325:Ringer's Lactate