Human depth ERP in a visual threshold recognition task.
Event-related potentials (ERPs) were recorded from the globus pallidus, the N. ventro-lateralis thalami and adjacent areas in parkinsonian patients bearing gold electrodes for diagnosis and therapy. The patients participated in a recognition task in which visual stimuli (digits) were presented at threshold durations. The ERPs from each single recording site, as separate histograms and then in combination as composite histograms across all recording sites ('profiles of reactions' and 'profiles of reaction differences'), were computed for 3 response types (correct, non-recognition, and incorrect). Four groups of depth-ERP components (N100, P200, N300, P300) were observed. The N100 was not found to be affected by the quality of recognition, manifest in type of response, while the later components were, but each in its own way. A comparison of these data with those of multiunit activity recorded from these same sites (see Bechtereva et al. 1990) shows that the pattern of the depth N100 and P200 components with reference to the 3 types of response have no observable counterparts in the impulse activity manifestations of subcortical neuronal populations, while the depth N300 and P300 are indeed associated with the neuronal impulse activity. This in turn supports the hypothesis concerning multiple (including subcortical) generators of the P300.
Kropotov
J D
JD
Department of Human Neurophysiology, Soviet Academy of Sciences, Leningrad, U.S.S.R.
Etlinger
S C
SC
D000328:Adult; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D010775:Photic Stimulation; D011930:Reaction Time; D013647:Task Performance and Analysis; D013787:Thalamic Nuclei / Q000503:physiopathology