[Relation between interferon-inducing activity of natural interferon inducers and their chemical structure].
The interferon-inducing activity of new derivatives of gossypol, a low molecular weight natural polyphenol, and its model compounds was studied in regard to their chemical structure. The active groups required for development of optimal interferon inductors on the basis of the natural polyphenols were defined. As a result of the studies the new interferon inductor AC-1 which is a condensation product of gossypol, a natural polyphenol, and a cellulose derivative was isolated. The interferon-inducing activity of AC-1 was investigated with respect to its dose and the administration route. High interferon-inducing activity of the interferon inductor after its administration by any route in doses of 10 to 100 mg/kg was demonstrated. The serum interferon titers reached 2560 units/ml.
Saĭitkulov
A M
AM
Ershov
F I
FI
Aslanov
Kh A
KhA
Tazupakhova
E B
EB
Maulianov
S A
SA
Achilova
G Sh
GSh
Amanova
S Kh
SKh
D000284:Administration, Oral; D000818:Animals; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006072:Gossypol / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007369:Interferon Inducers / Q000008:administration & dosage* / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D051379:Mice; D008954:Models, Biological
D007369:Interferon Inducers; C005062:acetylcellulose; D002482:Cellulose; D007372:Interferons; D006072:Gossypol
Zavisimost' interferonindutsiruiushcheĭ aktivnosti prirodnykh induktorov interferona ot ikh khimicheskoĭ struktury.