The chicken GABAA receptor alpha 1 subunit: cDNA sequence and localization of the corresponding mRNA.
We report the sequence of a complementary DNA (cDNA) that encodes the chicken GABAA receptor alpha 1 subunit, which is extremely homologous to mammalian alpha 1 subunits. The distribution of alpha 1 subunit transcripts is shown to correlate mainly, but not completely, with the previously-reported pattern of benzodiazepine type I (BZI) binding sites in the avian brain. These results suggest that the alpha 1 subunit may not necessarily be restricted to receptors having BZI pharmacology.
Bateson
A N
AN
MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, U.K.
Harvey
R J
RJ
Wisden
W
W
Glencorse
T A
TA
Hicks
A A
AA
Hunt
S P
SP
Barnard
E A
EA
Darlison
M G
MG
D000595:Amino Acid Sequence; D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D001921:Brain / Q000502:physiology*; D002642:Chick Embryo; D004247:DNA / Q000235:genetics*; D015723:Gene Library; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics*; D011963:Receptors, GABA-A / Q000235:genetics*; D013462:Sulfur Radioisotopes
D046911:Macromolecular Substances; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D011963:Receptors, GABA-A; D013462:Sulfur Radioisotopes; D011061:Poly A; D012313:RNA; D004247:DNA