title: [Amiodarone for long-term treatment of ventricular arrhythmias].
abstract: As one of the causes of sudden cardiac death, recurrent ventricular arrhythmia represents a potentially life-threatening rhythm disorder. amiodarone is an effective anti-arrhythmic drug, the effectiveness of which is based on a prolongation of the action potential and thus a lengthening of the refractory period. In a multicenter, noncontrolled observational study of 482 patients aged between 21 and 89, it was found that amiodarone effectively suppressed life-threatening or crippling arrhythmias in a majority of the patients, even when they had previously been unresponsive to other anti-arrhythmic agents. Physical performance improved under the treatment. An analysis of the side effects observed revealed good tolerance at a low maintenance dose.
authors.affiliation: SANOFI Pharma GmbH, München.
authors.forename: M
authors.initials: M
authors.lastname: Müller
authors.forename: K D
authors.initials: KD
authors.lastname: Wiedey
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage* / Q000009:adverse effects; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006352:Heart Ventricles / Q000187:drug effects*; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
chemical_list: D000638:Amiodarone
vernacular_title: Amiodaron zur Langzeitbehandlung ventrikulärer Arrhythmien.