title: Immunohistochemical comparison of actinic reticuloid with allergic contact dermatitis.
abstract: Biopsy specimens of chronic lesions and ultraviolet-induced lesions from actinic reticuloid patients were examined by immunoperoxidase techniques and compared with those of allergic contact dermatitis skin, one of the delayed-type hypersensitivity conditions. Each lesion of actinic reticuloid showed a clear predominance of suppressor/cytotoxic T cells to helper/inducer T cells and an increase of Langerhans cells in the epidermis and the dermis. These findings are generally similar to those in the late phase (on day 7 and 11) but not in the early phase (on day 2) of allergic contact dermatitis and suggest that delayed-type hypersensitivity might be involved in some parts of the pathogenesis of actinic reticuloid. CD36+DR+ epidermal cells were also observed in ultraviolet-induced lesions from actinic reticuloid patients, suggesting a possible role in the modulation of the mechanism.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kyoto University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Miyachi
authors.forename: T
authors.initials: T
authors.lastname: Horio
authors.forename: S
authors.initials: S
authors.lastname: Imamura
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000276:immunology / Q000502:physiology; D018955:CD36 Antigens; D003877:Dermatitis, Contact / Q000276:immunology / Q000378:metabolism*; D004485:Eczema / Q000276:immunology / Q000473:pathology; D004817:Epidermis / Q000276:immunology / Q000473:pathology; D006684:HLA-DR Antigens / Q000276:immunology / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D015703:Antigens, CD; D018955:CD36 Antigens; D006684:HLA-DR Antigens