Identification of the c-kit ligand: end of the road for understanding aplastic anemia in steel mutant mice?
We here report the initiation of hematopoietic recovery in congenitally hypoplastic S1/S1d mice by the cytotoxic ablation of cells bearing the natural killer (NK) phenotype (NK 1.1+). The most striking finding was the early several-fold increase in the cycling fraction of stem and progenitor cells (with the exception of progenitors committed to megakaryocytopoiesis) in the anti-NK 1.1+ antibody-treated group. This increase resulted in an early, complete restoration of total marrow cellularity to the normal (+/+) littermate level. Our data suggest that NK 1.1+ cells exert functions critical to the negative control of hematopoietic cell proliferation in S1/S1d mice.
Pantel
K
K
Division of Hematology and Oncology, Wayne State University School of Medicine, Detroit, MI.
Boertman
J
J
Nakeff
A
A
D000741:Anemia, Aplastic / Q000097:blood*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology*; D003114:Colony-Forming Units Assay; D016207:Cytokines / Q000097:blood; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D019009:Proto-Oncogene Proteins c-kit; D011956:Receptors, Cell Surface / Q000502:physiology*
D000911:Antibodies, Monoclonal; D016207:Cytokines; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D019009:Proto-Oncogene Proteins c-kit