Characteristics of histamine secretion from mast cells stimulated with sodium orthovanadate and other vanadium compounds.
Sodium orthovanadate was found to be an effective histamine liberator from serosal mast cells of the rat and mouse. The release process was slow, non-cytotoxic and strongly dependent on pH and extracellular calcium. The effect was highly tissue and species specific and human basophil leucocytes, human lung mast cells and tissue mast cells of the rat and guinea pig were only weakly responsive or essentially unreactive. Other oxyanions of vanadium with the metal in the (+V) oxidation state also evoked histamine release from rat peritoneal mast cells but neither vanadyl sulphate (+IV oxidation state) nor the analogous orthophosphate anion were effective secretagogues. On the basis of these results, the possible mechanism of action of vanadate is discussed.
al-Laith
M
M
Department of Chemistry, University College London, UK.
Pearce
F L
FL
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D010537:Peritoneum; D010994:Pleura; D051381:Rats; D013324:Strontium / Q000494:pharmacology; D014638:Vanadates / Q000494:pharmacology*; D014639:Vanadium / Q000494:pharmacology; D017968:Vanadium Compounds; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D017968:Vanadium Compounds; D014639:Vanadium; D014638:Vanadates; D003189:p-Methoxy-N-methylphenethylamine; C034028:vanadyl sulfate; C066075:vanadium pentoxide; D002118:Calcium; D013324:Strontium