[The effect of steroid sex hormones on the biosynthesis of alpha 2-macroglobulin and pregnancy-associated alpha 2-glycoprotein in cultures of peripheral blood mononuclear cells].
The peripheral blood mononuclears are capable of intense biosynthesis of alpha 2-macroglobulin and of weak biosynthesis of pregnancy-associated alpha 2-glycoprotein. Sex hormones of men and non-pregnant women exert no influence on the protein biosynthesis. During pregnancy alpha 2-macroglobulin biosynthesis is shortly activated, although it does not depend on the influence of sex hormones. All the steroid sex hormones provide a short-term biosynthesis of this protein during the II trimester of pregnancy, while testosteron inhibits it during the III trimester. Possible mechanisms of control of biosynthesis of these proteins are discussed.
Zorin
N A
NA
Mal'tseva
N V
NV
Zorina
R M
RM
Gorin
V S
VS
D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D002846:Chromatography, Affinity; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000096:biosynthesis / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology*; D013739:Testosterone / Q000494:pharmacology*; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000096:biosynthesis / Q000187:drug effects*
D011257:Pregnancy Proteins; D000511:alpha-Macroglobulins; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol
Vliianie steroidnykh polovykh gormonov na biosintez al'fa 2-makroglobulina i assotsiirovannogo s beremennost'iu al'fa 2-glikoproteina v kul'turakh perifericheskikh mononuklearnykh kletok krovi.