title: [Surgical therapy of HCG-producing mediastinal tumor accompanied with intrapulmonary metastasis].
abstract: The patient is a 31-year-old man who was suffering from hyperthyroidism and left hemothorax. His serum HCG level was extremely elevated and chest X-ray showed a mass shadow of anterior mediastinum and bilateral multiple intrapulmonary metastasis. Our clinical diagnosis was primary HCG-producing germ cell carcinoma of mediastinum and immediately administered CDDP and VP-16. Chemotherapy was effective and tumor extirpation was carried out for mediastinum and lungs by median sternotomy. All of the resected specimen showed no cancer cells and 4 years have passed with no evidence of recurrence. Aggressive surgical approach is indicated for mediastinal germ cell carcinoma accompanied with intrapulmonary metastasis when chemotherapy is effective.
authors.affiliation: Department of Thoracic Surgery, Niigata Cancer Center Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Souma
authors.forename: F
authors.initials: F
authors.lastname: Oguma
authors.forename: M
authors.initials: M
authors.lastname: Terashima
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D006063:Chorionic Gonadotropin / Q000096:biosynthesis*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D006063:Chorionic Gonadotropin; D001761:Bleomycin; D003609:Dactinomycin; D014747:Vinblastine; D002945:Cisplatin