[Study by the intracerebral microdialysis method of the effects of atypical neuroleptics and anxiolytics on striatal release and metabolism of dopamine in awake rats].
Using brain microdialysis in awake rats effects of risperidone, ritanserin, buspirone, sulpiride and 5-methoxy-N,N-dimethyltryptamine (MeODMT) on striatal dopamine (DA) release and metabolism were studied. Risperidone, sulpiride and buspirone increased levels of DA, dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). Ritanserin failed to affect DA release, while increased DOPAC and HVA levels. MeODMT had no effect on striatal DA release and metabolism. Possible interaction between DA and serotonin systems is discussed.
Bogdanov
M B
MB
Gaĭnetdinov
R R
RR
Kudrin
V S
VS
Medvedev
O S
OS
Val'dman
A V
AV
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001923:Brain Chemistry; D002065:Buspirone / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003956:Dialysis; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D018967:Risperidone; D016713:Ritanserin; D013469:Sulpiride / Q000494:pharmacology; D014851:Wakefulness
D014151:Anti-Anxiety Agents; D014150:Antipsychotic Agents; D007555:Isoxazoles; D008732:Methoxydimethyltryptamines; D010880:Piperidines; D016713:Ritanserin; D013469:Sulpiride; D018967:Risperidone; D002065:Buspirone; D004298:Dopamine
Izuchenie metodom vnutrimozgovogo mikrodializa vliianiia atipichnykh neĭroleptikov i anksiolitikov na vysvobozhdenie i metabolizm dofamina v striatume bodrstvuiushchikh krys.