title: Modified lymphocyte response to mitogens induced by the lipopeptide fragment derived from Mycobacterium avium serovar-specific glycopeptidolipids.
abstract: The beta-elimination procedure was used to obtain two major fragments of Mycobacterium avium glycopeptidolipid antigens. The lipopeptide fragment, not the oligosaccharide, diminished the mitogen-induced blastogenic response of spleen cells at concentrations lower than those which affected viability. Electron microscopy revealed an internalization of lipopeptide and disruption of intracellular organization.
authors.affiliation: Department of Microbiology and Immunology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.
authors.forename: S K
authors.initials: SK
authors.lastname: Tassell
authors.forename: M
authors.initials: M
authors.lastname: Pourshafie
authors.forename: E L
authors.initials: EL
authors.lastname: Wright
authors.forename: M G
authors.initials: MG
authors.lastname: Richmond
authors.forename: W W
authors.initials: WW
authors.lastname: Barrow
mesh_terms: D000818:Animals; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008055:Lipids / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009162:Mycobacterium avium / Q000737:chemistry* / Q000276:immunology; D009844:Oligosaccharides / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D006020:Glycopeptides; D007166:Immunosuppressive Agents; D008055:Lipids; D009844:Oligosaccharides