[The safety of the preparation viroden for vertebrate animals].
Toxicity-pathogenicity test of viroden, a new preparation, and its acting agent--a mosquito densonucleosis virus (MDV) has been carried out on warm-blooded animals. It is shown that the preparation is not toxic for laboratory animals (white common mice, rats, guinea pigs, rabbits), chicken embryos and cell cultures of warm-blooded animals. The MDV is not adapted to a warm-blooded organism with different ways of introduction and in passages. Using electron and luminescent microscopy, serological reactions, specific test systems and a biological test for sensitive insects no explicit or latent infection was found in animals, chicken embryos and cell cultures of vertebrates with primary infection and in passages. Sensibilized animals shown an immunological rearrangement of the organism proceeding by the retarded hypersensitivity type.
Vasil'eva
V L
VL
Lebedinets
N N
NN
Gurval'
A L
AL
Chigir'
T V
TV
Buchatskiĭ
L P
LP
Kuznetsova
M A
MA
D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000032:analysis; D002642:Chick Embryo; D000939:Epitopes / Q000032:analysis; D006168:Guinea Pigs; D007304:Insect Viruses / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D007306:Insecticides / Q000276:immunology / Q000302:isolation & purification / Q000633:toxicity*; D009930:Organic Chemicals; D010321:Parvoviridae / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D011817:Rabbits; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects
D000956:Antigens, Viral; D000939:Epitopes; D007306:Insecticides; D009930:Organic Chemicals; C054131:viroden
Issledovanie bezopasnosti preparata virodena dlia pozvonochnykh zhivotnykh.