Absence of mutagenicity of the antitumor drug 3-nitrobenzothiazolo[3,2-a]quinolinium chloride (NBQ) in the germ cells of Drosophila melanogaster males.
The antitumor drug, 3-nitrobenzothiazolo[3,2-a]quinolinium chloride (NBQ) was tested for genotoxicity with the sex-linked recessive lethal test by feeding Drosophila melanogaster males. Although toxic to adults, the drug tested negative at the concentrations studied.
Pérez-Chiesa
Y
Y
Department of Biology, University of Puerto Rico, Río Piedras 00931.
Arroyo
A
A
Rodriguez
D
D
Rodriguez-Stoehr
A
A
Cox
O
O
Retamozo
H R
HR
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D005260:Female; D005804:Genes, Lethal; D005808:Genes, Recessive; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods; D011806:Quinolinium Compounds / Q000633:toxicity*
D000970:Antineoplastic Agents; D011806:Quinolinium Compounds; C038668:3-nitrobenzothiazolo(3,2-a)quinolinium