The effect of Fluosol-DA and Hespan haemodilution on S-warfarin elimination in the rat.
Fluosol and Hespan haemodilution in rats did not change S-warfarin elimination within 72 h although previous studies had indicated that Fluosol haemodilution caused an increased cytochrome P450b and P450e activity at 48 h. This study showed that the increased activity at that time was specific for those isoenzymes.
Shrewsbury
R P
RP
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
Hong
D D
DD
D000818:Animals; D004338:Drug Combinations; D005466:Fluorocarbons / Q000494:pharmacology*; D006438:Hemodilution; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014859:Warfarin / Q000493:pharmacokinetics*
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D014859:Warfarin; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination