title: Polar spongioblastoma: an immunohistochemical and electron microscopical study.
abstract: A case is reported of a 9-year-old boy with a cerebral polar spongioblastoma. This neoplasm, first described by Russell and Cairns in 1947, is morphologically a distinct entity characterized by bipolar tumor cells with palisading nuclei. In the case under study immunoreactivity for neuron-specific enolase was found and ultrastructural features of developing neuronal elements were present. A neuro-endocrine nature was suggested by de Chadarévian et al. (1984) in a morphologically similar case. These findings are in contrast with the long-held view that the polar spongioblastoma is cytogenetically related to the embryonal radial glial cells.
authors.affiliation: Department of Pathology, Subdivision of Neuropathology, University Hospital Utrecht, The Netherlands.
authors.forename: G H
authors.initials: GH
authors.lastname: Jansen
authors.forename: D
authors.initials: D
authors.lastname: Troost
authors.forename: K P
authors.initials: KP
authors.lastname: Dingemans
mesh_terms: D001254:Astrocytoma / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D002648:Child; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D013194:Staining and Labeling