title: Acute noncardiac chest pain in a coronary care unit. Evaluation by 24-hour pressure and pH recording of the esophagus.
abstract: Twenty-four-hour recording of esophageal pressure and pH was performed successfully in 41 patients admitted to the coronary care unit of a general hospital who had an episode of acute, prolonged retrosternal chest pain and who were initially suspected of suffering from coronary artery disease (severe angina pectoris, myocardial infarction), but in whom the pain was subsequently shown not to be of cardiac origin. The recordings were analyzed with fully automated techniques. A pain episode was considered to be related to abnormal esophageal motility when contraction amplitudes or durations in the pain episode exceeded the patient's upper limit of normal (97.5th percentile) or when the proportion of abnormal propagated contractions (simultaneous, nontransmitted) in the pain episode was significantly increased (chi 2 test). Thirty patients (73%) had one or more pain episodes (in total 63 pain episodes) during the 24-hour recording. Forty-three percent of the pain episodes was related to abnormal motility and 30% to reflux, and 27% was not related to esophageal function disturbance. Using the criterium that the symptom index had to be greater than or equal to 75%, it was found that the pain was related to reflux in 13 patients (43%) and to motor abnormalities in 10 patients (33%). It is concluded that in the majority of patients acutely admitted with noncardiac chest pain, esophageal motor abnormalities and reflux can be shown to be the likely cause of the symptoms.
authors.affiliation: Department of Internal Medicine, St. Elisabeth of Groote Gasthuis, Haarlem, The Netherlands.
authors.forename: H G
authors.initials: HG
authors.lastname: Lam
authors.forename: W
authors.initials: W
authors.lastname: Dekker
authors.forename: G
authors.initials: G
authors.lastname: Kan
authors.forename: M
authors.initials: M
authors.lastname: Breedijk
authors.forename: A J
authors.initials: AJ
authors.lastname: Smout
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002637:Chest Pain / Q000209:etiology*; D003325:Coronary Care Units; D003937:Diagnosis, Differential; D015154:Esophageal Motility Disorders / Q000150:complications* / Q000175:diagnosis; D004942:Esophagitis, Peptic / Q000150:complications; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic