title: Ph-positive chronic myeloid leukemia with t(8;21)(q22;q22) in blastic crisis.
abstract: A patient diagnosed with chronic myeloid leukemia was studied periodically during his illness. The result showed the presence of a Philadelphia (Ph) chromosome by a 9;22 translocation as a single abnormality to the time of blastic crisis. At that time, the chromosome studies showed a clonal evolution. Furthermore, a second derivated line was added to the Ph line. This new anomaly consisted of a 8;21 translocation, considered as specific of M2 type acute nonlymphoblastic leukemia of French-American-British classification.
authors.affiliation: Medical Genetics Department, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: M T
authors.initials: MT
authors.lastname: Ferro
authors.forename: J L
authors.initials: JL
authors.lastname: Steegman
authors.forename: L
authors.initials: L
authors.lastname: Escribano
authors.forename: B
authors.initials: B
authors.lastname: Heiurichs
authors.forename: L
authors.initials: L
authors.lastname: Parada
authors.forename: J M
authors.initials: JM
authors.lastname: García-Sagredo
authors.forename: M
authors.initials: M
authors.lastname: Resino
authors.forename: P
authors.initials: P
authors.lastname: Cabello
authors.forename: C
authors.initials: C
authors.lastname: San Román
mesh_terms: D000328:Adult; D001752:Blast Crisis; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008297:Male; D010677:Philadelphia Chromosome; D014178:Translocation, Genetic