title: Biannual radiographic assessments of hands and feet in a three-year prospective followup of patients with early rheumatoid arthritis.
abstract: In a prospective followup study of 147 patients with rheumatoid arthritis of recent onset, we assessed the progression of radiographic evidence of joint damage on films of the patients' hands and feet obtained biannually. Patients were receiving first-line and second-line treatment. Ninety patients were followed up for 3 years, and 57 were followed up for only 2 years. Radiographic damage was determined by a modification of the method described by Sharp, and to ensure comparability of findings, we determined the percentage of damage per joint group (actual score divided by the maximum possible score). After 3 years, radiographic damage was present in 70% of the patients, all of whom could be identified after 1 year of study. Overall, 18-20% of the joints of the hands and feet were affected after 3 years, with relatively little abnormality per joint (approximately 8% of maximum possible score). During the entire followup, more foot joints than hand joints were affected. The rate of progression in the first year was significantly higher than in the second and third years of study, indicating a flattening of the curve of radiographic progression of joint damage.
authors.affiliation: Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
authors.forename: D M
authors.initials: DM
authors.lastname: van der Heijde
authors.forename: M A
authors.initials: MA
authors.lastname: van Leeuwen
authors.forename: P L
authors.initials: PL
authors.lastname: van Riel
authors.forename: A M
authors.initials: AM
authors.lastname: Koster
authors.forename: M A
authors.initials: MA
authors.lastname: van 't Hof
authors.forename: M H
authors.initials: MH
authors.lastname: van Rijswijk
authors.forename: L B
authors.initials: LB
authors.lastname: van de Putte
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000000981:diagnostic imaging* / Q000473:pathology; D007839:Functional Laterality / Q000502:physiology; D015804:HLA-DR4 Antigen / Q000032:analysis; D006225:Hand / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012217:Rheumatoid Factor / Q000032:analysis; D013997:Time Factors
chemical_list: D015804:HLA-DR4 Antigen; D007075:Immunoglobulin M; D012217:Rheumatoid Factor