[Character and reasons for change in mitochondrial ATP content during auto-oscillation of ion currents].
The changes in the adenosine triphosphate content in the course of ionic flux oscillations in mitochondria were estimated by using the chemiluminescence method. The ATP concentration changes were shown to be of cyclic character; the oscillations in the ATP content were shifted by 180 degrees C against those of K+ fluxes. The oligomycin-induced oxidative phosphorylation blocking changed (but did not eliminate) the oscillational character of the ATP content in mitochondrial suspensions. It was concluded that substrate phosphorylation is the source of ATP under conditions of oxidative phosphorylation inhibition. Incubation of mitochondria in the presence of exogenous ATP led to suppression of ionic flux oscillations.
Teplova
V V
VV
Sidash
S S
SS
Evtodienko
Iu V
IuV
Kholmukhamedov
E L
EL
D000255:Adenosine Triphosphate / Q000096:biosynthesis / Q000378:metabolism*; D000818:Animals; D002413:Cations, Divalent; D006868:Hydrolysis; D007473:Ion Channels / Q000378:metabolism*; D008163:Luminescent Measurements; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013324:Strontium / Q000494:pharmacology
D002413:Cations, Divalent; D007473:Ion Channels; D000255:Adenosine Triphosphate; D011188:Potassium; D013324:Strontium
Kharakter i prichiny izmeneniyia soderzhaniia ATP v mitokhondriiakh v khode avtokolebaniĭ ionnykh potokov.