title: Development of very low birth weight infants: a regional study of 371 survivors.
abstract: We re-examined 371 infants with birth weights less than 1501 g at a corrected age of 18-20 months. This sample amounted to 91% of such infants admitted to one of the six neonatal intensive care units in Hamburg between July 1983 and 1986. The neurological examination and a developmental evaluation using the Griffith Developmental Scale revealed higher rates of abnormalities than in most other studies. Fifty-five children (14.8%) suffered from cerebral palsy, classified in 45 as spastic diplegia, in 5 as spastic tetraplegia, in 1 as spastic hemiplegia and in 4 as dystonia. Of the children, 41 (11%) showed minor neurological deviations (hyperactivity, clumsiness, intention tremor). The development of 30 children (8%) without neurological abnormalities was moderately retarded (DQ 80-89, corrected for gestational age [GA]). Nineteen children (5%) were severely retarded (DQ less than 80, corrected for GA) and four children (1.5%) were blind due to retrolental fibroplasia. An isolated delay of speech development was found in 5 children. Seventy children (18.9%) had a major and 87 children (23.5%) a minor handicap.
authors.affiliation: Department of Paediatrics, University Hospital Hamburg, Federal Republic of Germany.
authors.forename: N
authors.initials: N
authors.lastname: Veelken
authors.forename: K
authors.initials: K
authors.lastname: Stollhoff
authors.forename: M
authors.initials: M
authors.lastname: Claussen
mesh_terms: D002547:Cerebral Palsy / Q000453:epidemiology; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000453:epidemiology*; D006233:Persons with Disabilities; D005260:Female; D005500:Follow-Up Studies; D005860:Germany, West / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007230:Infant, Low Birth Weight / Q000254:growth & development*; D007231:Infant, Newborn; D008297:Male; D009422:Nervous System Diseases / Q000453:epidemiology*; D011379:Prognosis