Lack of effect of perindopril on plasma and adrenal corticosteroids in the guinea pig during the estrous cycle and under contraceptive treatment.
We studied changes in cortisol, aldosterone, progesterone, estrogens and cholesterol in cyclic female guinea-pigs and in animals under contraceptive, treated or not with an inhibitor of angiotensin converting enzyme (ACE): perindopril. Perindopril decreased ACE by 80% without affecting steroid profiles. Peak value for plasma progesterone occurred at meta-estrus and diestrus. It disappeared under contraceptive treatment. The very low levels of estrogens in the female guinea pig remained unchanged in all cases. Plasma cortisol concentrations were higher at pro-estrus and estrus whereas plasma aldosterone concentrations remained constant during the estrous cycle and under contraceptive treatment. Furthermore, aldosterone did not change under perindopril treatment despite the decrease of the activity of ACE. The contraceptive treatment decreased plasma cholesterol levels. Under perindopril treatment, this drop was amplified. No change was detected in adrenal steroid concentrations, except for progesterone which decreased under contraceptive treatment.
Buisson
S
S
Laboratoire de Physiologie Animale, Université Blaise Pascal-Clermont-Ferrand II, Ensemble Scientifique des Cézaux, France.
Laurant
P
P
Dalle
M
M
Devissaguet
M
M
Scalbert
E
E
D000305:Adrenal Cortex Hormones / Q000097:blood* / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood / Q000378:metabolism; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D004967:Estrogens / Q000097:blood / Q000378:metabolism; D004971:Estrus / Q000502:physiology*; D005260:Female; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology*; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D020913:Perindopril; D011374:Progesterone / Q000097:blood / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D000806:Angiotensin-Converting Enzyme Inhibitors; D003271:Contraceptive Agents, Female; D004967:Estrogens; D007211:Indoles; D000450:Aldosterone; D011374:Progesterone; D002784:Cholesterol; D007703:Peptidyl-Dipeptidase A; D006854:Hydrocortisone; D020913:Perindopril