Insulin-like growth factor II (IGF-II) mRNA expression during hepatocarcinogenesis in transgenic mice.
Insulin-like growth factor II (IGF-II) mRNA expression is developmentally regulated in liver tissue. We previously observed the reexpression of fetal IGF-II mRNAs in human primary liver cancer and in surrounding cirrhotic tissue. In order to determine the steps of liver cancer progression where the activation of IGF-II fetal mRNAs occurs, we analyzed IGF-II mRNA expression during hepatocarinogenesis in transgenic mice carrying an antithrombin III-SV40 early region hybrid gene. The comparative analysis of mRNAs encoding IGF-II and other differentiation-associated proteins, as well as histological analysis, indicate that the reexpression of fetal IGF-II mRNAs takes place in specific steps of liver cancer progression, both in early pretumorous lesions and in well-differentiated hepatocellular carcinomas.
Cariani
E
E
INSERM U 75, CHU Necker, Paris, France.
Dubois
N
N
Lasserre
C
C
Briand
P
P
Brechot
C
C
D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D015152:Blotting, Northern; D007335:Insulin-Like Growth Factor II / Q000235:genetics* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D009954:Ornithine Carbamoyltransferase / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000302:isolation & purification; D013539:Simian virus 40 / Q000235:genetics; D000509:alpha-Fetoproteins / Q000378:metabolism
D012333:RNA, Messenger; D000509:alpha-Fetoproteins; D007335:Insulin-Like Growth Factor II; D009954:Ornithine Carbamoyltransferase