Pentagastrin-stimulated histamine release and acid secretion from the totally isolated vascularly perfused rat stomach.
This study was performed to examine the effect of cAMP levels on histamine release in the isolated rat stomach. Pentagastrin-induced histamine release was unaffected by phosphodiesterase inhibition, and pentagastrin itself had no phosphodiesterase-like effect. The results support previous observations showing that histamine is likely to be the mediator of the acid secretagogue effect of (penta) gastrin.
Iwasa
K
K
Department of Medicine, University Hospital, Trondheim, Norway.
Sandvik
A K
AK
Waldum
H L
HL
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D006632:Histamine; D010418:Pentagastrin; D015056:1-Methyl-3-isobutylxanthine