New agents to increase the permeability of the outer membrane of Escherichia coli.
Two diamines were prepared to investigate the structure-activity relationship required for an increase in the permeability of the outer membrane of Escherichia coli. It was found that diamine (a), bis[4-(2-methylaminoethoxy)phenyl]methane dihydrochloride, increased the permeability of the membrane, while diamine (b), 1,4-bis(2-methylaminoethoxy)benzene dihydrochloride, did not. The result indicated that the existence of bulky hydrophobic moiety is important to cause an increase in the permeability.
Katsu
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Faculty of Pharmaceutical Sciences, Okayama University, Japan.
D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003959:Diamines / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D006096:Gramicidin / Q000494:pharmacology; D007700:Kinetics; D009570:Nitriles / Q000494:pharmacology; D009861:Onium Compounds / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000378:metabolism; D011188:Potassium / Q000378:metabolism
D003959:Diamines; D009570:Nitriles; D009861:Onium Compounds; D009943:Organophosphorus Compounds; C100076:mesoxalonitrile; C070026:bis(4-(2-methylaminoethoxy)phenyl)methane; C070027:1,4-bis(2-methylaminoethoxy)benzene; D006096:Gramicidin; D002259:Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; D011188:Potassium; C013289:tetraphenylphosphonium