Antigen processing and presentation.
An overview of the various aspects of antigen degradation and presentation is given with special emphasis on the possible occurrence of variation in the enzymatic machinery present in different cells or individuals. Different procedures for epitope mapping are also presented as well as the characterization of universal epitopes in humans. The latter finding is of considerable importance for the development of subunit vaccines. Finally, the structure of T cell epitopes is discussed.
Corradin
G
G
Biochemistry Institute, University of Lausanne, Epalinges, Switzerland.
D000818:Animals; D000941:Antigens / Q000378:metabolism*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D010455:Peptides / Q000276:immunology; D011487:Protein Conformation; D013601:T-Lymphocytes / Q000276:immunology; D014612:Vaccines / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D010455:Peptides; D014612:Vaccines