Antibody response to serotype-specific and cross-reactive neutralization epitopes on VP4 and VP7 after rotavirus infection or vaccination.
By using a competitive solid-phase immunoassay with serotype-specific and cross-reactive neutralizing monoclonal antibodies directed at VP4 and VP7, we tested the antibody responses to some neutralization epitopes on VP4 and VP7 in individuals infected or vaccinated with rotavirus. Antibody responses to VP7 epitopes of the infecting serotype of virus were found at a high frequency in both infants and children. In contrast, antibody responses to VP4 and heterotypic VP7 were observed only when the individuals possessed antibodies to any serotype of rotavirus in their acute-phase or prevaccination sera.
Taniguchi
K
K
Department of Hygiene, Sapporo Medical College, Japan.
Urasawa
T
T
Kobayashi
N
N
Ahmed
M U
MU
Adachi
N
N
Chiba
S
S
Urasawa
S
S
D000914:Antibodies, Viral / Q000096:biosynthesis*; D000956:Antigens, Viral; D002213:Capsid / Q000276:immunology*; D036022:Capsid Proteins; D002648:Child; D003429:Cross Reactions; D000939:Epitopes; D006801:Humans; D007223:Infant; D009500:Neutralization Tests; D012401:Rotavirus / Q000145:classification / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology; D012703:Serotyping; D014765:Viral Vaccines / Q000494:pharmacology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D036022:Capsid Proteins; D000939:Epitopes; C060339:VP4 protein, Rotavirus; C050779:VP7 protein, Rotavirus; D014765:Viral Vaccines