title: Cavernous angiomas of the central nervous system in children.
abstract: A surgical series of 19 patients under the age of 18 years with pathologically verified cavernous angioma is presented. Most lesions were located in the cerebral hemispheres, but four were in the pons or midbrain, two in the diencephalon, and one in the spinal cord. Fourteen patients presented with an acute or progressing neurological deficit, three with seizures, one infant with irritability, and one with headache alone. Five patients had family histories of vascular malformations of the central nervous system, and five had multiple lesions. Surgery for small or deep lesions was aided considerably by intraoperative ultrasonographic or stereotactic localization techniques. Pathological examination of the resected malformations revealed a complex histology containing not only typical closely approximated cavernous vessels, but also areas of marked proliferation of granulation tissue and partially re-endothelialized hemorrhage, suggesting a mechanism for the apparent growth of certain cavernous angiomas. The postoperative results were good, with only one patient suffering a permanent worsening of neurological status after surgery. Incomplete resection was initially carried out in five patients, two of whom rebled within 1 year after operation. Long-term follow-up findings in these patients have emphasized the unusual history of certain of these malformations.
authors.affiliation: Department of Neurosurgery, Children's Hospital, Boston, Massachusetts.
authors.forename: R M
authors.initials: RM
authors.lastname: Scott
authors.forename: P
authors.initials: P
authors.lastname: Barnes
authors.forename: W
authors.initials: W
authors.lastname: Kupsky
authors.forename: L S
authors.initials: LS
authors.lastname: Adelman
mesh_terms: D000293:Adolescent; D016543:Central Nervous System Neoplasms / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006392:Hemangioma, Cavernous / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007223:Infant; D002538:Intracranial Arteriovenous Malformations / Q000150:complications; D008297:Male