title: Renin-angiotensin system in thyroidectomized rats at different periods of development.
abstract: The relationship between the renal function and some components of the renin-angiotensin system has been studied in hypothyroid rats thyroidectomized surgically at different periods of their life. Changes in plasma renin concentration (PRC) depending on the period hypothyroidism were induced. Results showed that the renin release control could result from an equilibrium between the reduced beta-adrenergic activity and the marked natriuresis observed in hypothyroidism. A reduction in plasma angiotensinogen concentration (PAC), due to a decrease in its hepatic production, was observed in thyroidectomized animals. PAC reduction was independent of the hypothyroidism induction period. Alterations in plasma renin activity (PRA) were a consequence of PRC and PAC changes in thyroidectomized animals, as an increase in fractional sodium excretion (FENa) time course dependent, was found in these rats.
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad de Málaga, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Jiménez
authors.forename: M
authors.initials: M
authors.lastname: Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Montiel
authors.forename: J A
authors.initials: JA
authors.lastname: Narvaez
authors.forename: J L
authors.initials: JL
authors.lastname: Dieguez
authors.forename: M
authors.initials: M
authors.lastname: Morell
mesh_terms: D000375:Aging / Q000502:physiology*; D000808:Angiotensinogen / Q000097:blood; D000818:Animals; D007668:Kidney / Q000502:physiology; D008297:Male; D009318:Natriuresis / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology*; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy
chemical_list: D000808:Angiotensinogen; D012083:Renin