Fluorescence, CD, and NMR studies on spantide, a bombesin and substance P antagonist.
The conformational properties of spantide [(D-Arg, D-Trp, Leu) substance P] have been studied by fluorescence, CD, and nmr techniques. The fluorescence, CD, and nmr parameters in different solvents and in a micellar environment (SDS) are compared with the data collected for bombesin. A preliminary investigation on [D-Pro] spantide is also reported.
Di Bello
C
C
Institute of Industrial Chemistry, University of Padova, Italy.
Scatturin
A
A
D'Auria
G
G
Gargiulo
M
M
Paolillo
L
L
Trivellone
E
E
De Castiglione
R
R
D000595:Amino Acid Sequence; D001839:Bombesin / Q000737:chemistry*; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013373:Substance P / Q000031:analogs & derivatives* / Q000737:chemistry
D012996:Solutions; D013373:Substance P; C042867:spantide; D001839:Bombesin