title: [Large cell anaplastic lymphomas in the immunocompromised host].
abstract: Large cell anaplastic (LCA) lymphomas are a newly defined tumor entity, which has recently been integrated in the updated Kiel classification. The occurrence of CD30+ LCA lymphoma in the setting of renal transplant patients has so far been reported only once. This report describes two LCA lymphomas of B-cell phenotype in renal transplant patients. The clonal evolution and possible etiologic role of Epstein-Barr Virus (EBV) in LCA lymphoma was studied. Our findings give further evidence that clonal evolution of B-cell populations is a second event in lymphomagenesis and is, at least in the cases studied, preceeded by either reactivated latent or primary EBV-infection with clonal EBV proliferation.
authors.affiliation: Pathologisches Institut, Universität Bern.
authors.forename: B
authors.initials: B
authors.lastname: Borisch
authors.forename: M F
authors.initials: MF
authors.lastname: Fey
authors.forename: A
authors.initials: A
authors.lastname: Tobler
authors.forename: K
authors.initials: K
authors.lastname: Bürki
authors.forename: K C
authors.initials: KC
authors.lastname: Gatter
authors.forename: J S
authors.initials: JS
authors.lastname: Wainscoat
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D001344:Autopsy; D001706:Biopsy; D015139:Blotting, Southern; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D006566:Herpesviridae Infections / Q000150:complications / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D017730:Ki-1 Antigen; D016030:Kidney Transplantation / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D015183:Restriction Mapping
chemical_list: D015703:Antigens, CD; D000951:Antigens, Neoplasm; D004279:DNA, Viral; D017730:Ki-1 Antigen
vernacular_title: Grosszellige anaplastische Lymphome bei Immunsuppression.