The human skin mast cell: a comparison with the human lung cell and a novel mast cell type, the uterine mast cell.
The functional and histochemical properties of isolated mast cells from human skin, uterine myometrium and lung parenchyma were compared. The skin cell showed a marked difference in responsiveness to both secretagogues and anti-allergic compounds when compared to mast cells from the uterus and lung. The latter cell types responded more strongly to immunologically-directed ligands and calcium ionophores than the skin cell. However, the skin cell released histamine in response to a wide variety of polycationic compounds whilst the lung and uterine cells were essentially refractory to these agents. The antiallergic drugs, disodium cromoglycate (DSCG) and nedocromil sodium, were weakly inhibitory against the skin cell but were in contrast more effective against the lung and uterine cells.
Tainsh
K R
KR
Department of Chemistry, University College London, UK.
Lau
H Y
HY
Liu
W L
WL
Pearce
F L
FL
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D002469:Cell Separation; D004205:Cromolyn Sodium / Q000494:pharmacology; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D015759:Ionomycin / Q000494:pharmacology; D008168:Lung / Q000166:cytology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D017835:Nedocromil; D015363:Quinolones / Q000494:pharmacology; D012867:Skin / Q000166:cytology*; D013373:Substance P / Q000494:pharmacology; D014599:Uterus / Q000166:cytology*; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000888:Antibodies, Anti-Idiotypic; D015363:Quinolones; D017835:Nedocromil; D013373:Substance P; D007073:Immunoglobulin E; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; D015759:Ionomycin; D004205:Cromolyn Sodium