[Chemostimulation and catecholamine content of the rat adrenal medulla].
Unanaesthetized rats whose arterial chemoreceptors were stimulated by an one hour acute exposition to hypoxic gaseous mixtures with various carbon dioxide concentrations, presented depletion of the catecholamines content of their adrenal glands only when hypocapnia or increased pH was present (non compensated hypoxia). Moreover, exposition to simultaneous hypoxia and hypercapnia increased the epinephrine stock of the adrenal glands. No changes were found in the myocardium amine content in the same conditions. When anaesthetized rats were treated by iv injection of almitrine bismesylate, a peripheral chemoreceptors stimulating drug, adrenal catecholamines content was insignificantly reduced. In the myocardium, the amines remained at control levels. The most powerful factor related to catecholamines depletion in the adrenals seems to be the hypocapnia or the alkalosis induced by the hyperventilation provoked by glomic stimulation. No indication has been found in favor of an effective adrenergic stimulation caused directly by chemoreceptors stimulation.
Lagneaux
D
D
Institut Léon Fredericq, C.H.U., Université de Liège, Belgique.
Lecomte
J
J
Rahman
M
M
Remacle
R
R
D000313:Adrenal Medulla / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D015765:Almitrine / Q000494:pharmacology; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology; D002395:Catecholamines / Q000378:metabolism*; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D004525:Efferent Pathways / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D002245:Carbon Dioxide; D015765:Almitrine
Chémostimulation et teneur de la médullo-surrénale du rat en catécholamines.