Properties of tuberomammillary histamine neurones and their response to galanin.
Histaminergic neurones in the tuberomammillary nucleus possess electrophysiological properties which distinguish them from other neurones in their neighborhood. Their resting potential is -50 mV and they are spontaneously active at about 2 Hz in a slice preparation. They display a transient outward rectification and an anomalous inward rectification. Bath application of galanin (0.1 microM) reduced their firing rate significantly and hyperpolarized them slightly.
Schönrock
B
B
Institut für Physiologie und Pathophysiologie, Johannes-Gutenberg Universität Mainz.
Büsselberg
D
D
Haas
H L
HL
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004594:Electrophysiology; D019004:Galanin; D006632:Histamine / Q000502:physiology*; D008326:Mammillary Bodies / Q000166:cytology / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D014371:Tuber Cinereum / Q000166:cytology / Q000502:physiology*
D010455:Peptides; D006632:Histamine; D019004:Galanin