Inhibitory effect of caerulein on salivary secretion in man.
Previous works have documented that pentagastrin has a stimulatory effect on salivary secretion. In this paper, we have studied the action of caerulein, a peptide that has an active gastrin-like terminal tetrapeptide, on salivary secretion in man. Our data documented that caerulein and pentagastrin have similar excitatory effect on gastric secretion in man, but different actions on salivary flow. Caerulein, at increasing doses, inhibits salivary flow, but not the secretion of amylase; this effect is statistically significant at 0.5 micrograms/kg/h which is the same dose that maximally stimulates gastric secretion. The inhibitory effect of caerulein was not reversed by previous injection of papaverin.
Loguercio
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Cattedra di Fisiopatologia Digestiva, I Medical School, Naples, Italy.
Costato
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Del Vecchio Blanco
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D000328:Adult; D000681:Amylases / Q000378:metabolism; D002108:Ceruletide / Q000008:administration & dosage / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D006801:Humans; D008297:Male; D010208:Papaverine / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D012469:Salivary Glands / Q000187:drug effects*; D012472:Salivation / Q000187:drug effects*; D013268:Stimulation, Chemical
D002108:Ceruletide; D010208:Papaverine; D000681:Amylases; D010418:Pentagastrin