Biological activity of 3-deazauridine nucleoside analogue: a theoretical study.
The incorporation model of Sanyal et al. has been used to understand the biological activity of the cytostatic compound 3-deazauridine. The interaction energies of various types of binding pattern of the enterant molecule with nucleic acid fragments have been computed. The energy values and the sites of association of the analogous base, obtained by optimization of energy values as well as the sites of association of nucleic acid bases during the transcription process have been compared. The specificity of the binding of the interacting molecule has been discussed, along with the inhibitory effect of 3-deazauridine. They are in agreement with the experimentally observed evidence.
Ojha
R P
RP
Department of Physics, University of Gorakhpur, India.
Sanyal
N K
NK
D015092:3-Deazauridine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D006860:Hydrogen Bonding; D008954:Models, Biological; D012313:RNA / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D015092:3-Deazauridine; D012313:RNA