Attenuation in detection of somatosensory stimuli by transcranial magnetic stimulation.
Effects of magnetic stimulation (MS) of the scalp and direct cortical electrical stimulation on detection of an electrical stimulus to the index finger (S1) were studied in 7 normal volunteers and a patient with epilepsy. Detection of somatosensory stimuli was attenuated when MS was delivered 200 msec before S1, was blocked when MS was delivered simultaneously to and 20 msec after S1, and was fully recovered when MS was delivered 200 msec after S1. This effect showed topographic specificity, being produced by scalp stimulation of restricted scalp positions contralateral to the finger stimulated, was maximal with low intensities of finger stimulation and high intensities of MS (usually over that required for motor threshold), and could also be produced in the absence of motor evoked responses in a peripheral hand muscle. These results show that a focal cortical stimulus can briefly attenuate detection of somatosensory stimuli before, during, and after cortical arrival of a somatosensory afferent volley. Several different mechanisms probably contribute to this phenomenon.
Cohen
L G
LG
Human Cortical Physiology Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Bandinelli
S
S
Sato
S
S
Kufta
C
C
Hallett
M
M
D000328:Adult; D004558:Electric Stimulation; D004576:Electromyography; D004827:Epilepsy / Q000503:physiopathology; D005260:Female; D005385:Fingers / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000503:physiopathology; D012016:Reference Values; D012535:Scalp / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation