title: [Immunophenotypic and genotypic characterization of T-cell populations in thymomas].
abstract: The T cell component of eight thymomas has been studied by immunohistochemistry and Southern blot analysis. In the cortical areas of thymomas the T cells expressed an immature cortical phenotype. In cortical and medullary areas T cell Receptor (TcR) alpha-beta lymphocytes heavily predominated over TcR gamma-delta lymphocytes. No genomic rearrangement of TcR and Immunoglobulin genes could be detected, thus supporting the non neoplastic nature of the lymphocyte component in thymomas.
authors.affiliation: Institut für Pathologie, Universität Zürich.
authors.forename: C C
authors.initials: CC
authors.lastname: Scherrer
authors.forename: H
authors.initials: H
authors.lastname: Knecht
authors.forename: M
authors.initials: M
authors.lastname: Wiesli
authors.forename: O R
authors.initials: OR
authors.lastname: Dirsch
authors.forename: B
authors.initials: B
authors.lastname: Odermatt
authors.forename: P U
authors.initials: PU
authors.lastname: Heitz
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D013945:Thymoma / Q000276:immunology* / Q000473:pathology; D013953:Thymus Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D015703:Antigens, CD; D006684:HLA-DR Antigens; D007136:Immunoglobulins
vernacular_title: Immunphaenotypische und genotypische Charakterisierung der T-Zellpopulation in Thymomen.