Priming effects of mammalian tachykinins on human neutrophils.
The undecapeptide substance P (SP) is known to activate different cell types involved in inflammatory and immune processes. By evaluating primed stimulation of human neutrophils, we now demonstrate that SP (10 nM-0.1 mM) dose-dependently enhances superoxide anion production from cells stimulated by the phospholipid mediator Platelet Activating Factor (PAF). We also provide evidence that neurokinin A (NKA), which is released, as well as SP, from C fibers of sensory nerves, potentiates PAF-evoked superoxide anion generation, while neurokinin B (NKB) is ineffective.
Brunelleschi
S
S
Dept. Pharmacology, Univ. Florence, Italy.
Tarli
S
S
Giotti
A
A
Fantozzi
R
R
D004305:Dose-Response Relationship, Drug; D006801:Humans; D015288:Neurokinin A / Q000494:pharmacology; D015287:Neurokinin B / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects*; D010972:Platelet Activating Factor / Q000494:pharmacology; D013268:Stimulation, Chemical; D013373:Substance P / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism; D015320:Tachykinins / Q000494:pharmacology*
D010972:Platelet Activating Factor; D015320:Tachykinins; D013481:Superoxides; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B