[A surface membrane study of human cell lines with different interferon sensitivities].
A comparative study of surface membranes of human cell J-96 and J-48 cultures with different sensitivity to alpha/beta interferon (IF). Reduced sensitivity of J-41 cells to IF-alpha/beta was found to be accompanied by a loss of highly specific receptors for IF-alpha, the lack of changes in the cell surface structures upon treatment with IF-alpha/beta, reduced intensity of cell fusion upon successive treatment with IF and polyethylene glycol. The results are discussed in connection with the observed changes in the activity of superoxide dismutase in J-96 and J-41 cell lines after treatment with IF.
Narovlianskiĭ
A N
AN
Amchenkova
A M
AM
Alimov
E G
EG
Gosteva
V V
VV
Klitsunova
N V
NV
Khesin
Ia E
IaE
D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D002478:Cells, Cultured / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D004351:Drug Resistance; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism; D007372:Interferons / Q000378:metabolism / Q000494:pharmacology*; D008854:Microscopy, Electron; D011971:Receptors, Immunologic / Q000187:drug effects / Q000378:metabolism; D017471:Receptors, Interferon; D013482:Superoxide Dismutase / Q000378:metabolism
D007370:Interferon Type I; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D007372:Interferons; D013482:Superoxide Dismutase
Issledovanie poverkhnostnykh membran v liniiakh chelovecheskikh kletok s razlichnoĭ chuvstvitel'nost'iu k interferonu.