[Effect of dextran 40,000 on collagen-induced platelet aggregation].
In blood samples of 12 healthy male volunteers under 50 years old the collagen induced platelet aggregation and the influence of a new 10% dextran 40.000 (Dextran Ebewe) was studied. Dextran was added to the samples with a concentration from 10 microliters up to 50 microliters/ml blood. In a concentration of 20 microliters/ml blood a significantly reduced collagen induced platelet aggregation was be observed. Higher dosages did not differ in a significant manner from this effect.
Költringer
P
P
Krankenhaus der Barmherzigen Brüder, Graz-Eggenberg.
Langsteger
W
W
Lind
P
P
Klima
G
G
Reisecker
F
F
Eber
O
O
D000328:Adult; D001161:Arteriosclerosis / Q000097:blood; D003094:Collagen / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D013927:Thrombosis / Q000097:blood
D003911:Dextrans; D010975:Platelet Aggregation Inhibitors; D003094:Collagen
Der Einfluss von Dextran 40.000 auf die kollageninduzierte Thrombozytenaggregation.