title: [Correction of disorders of tissue perfusion in surgical patients in critical conditions and their evaluation by changes in the indices of the acid-soluble fractions of blood plasma].
abstract: Rheopolyglucin infusion and vasodilation therapy with droperidol have been performed in 16 critically ill surgical patients with low O2 tissue utilization with the aim in view to assess tissue perfusion disturbances and normalize peripheral blood flow. Basic central hemodynamic parameters and oxygen transport system parameters have been determined. Using gel filtration, acid-soluble blood plasma fractions have been studied spectrophotometrically. Despite the fact that rheopolyglucin infusion caused an increase in oxygen flow index (OFI) at the expense of cardiac index (CI) growth, O2 extraction remained practically unchanged. Vasodilation therapy, with slight changes of CI and OFI, caused an increase in O2 consumption and arterio venous difference, as well as a reduction of mixed venous blood pO2, this accompanied by an increase in acid-soluble blood plasma fractions, especially second fraction at 255 nm. A direct correlation has been established between basic oxygen transport system parameters, characterizing O2 tissue utilization and changes of acid-soluble blood plasma fractions parameters. The changes in acid-soluble blood plasma fractions parameters may serve one of the criteria characterizing the efficacy of procedures aimed at the improvement of tissue perfusion.
authors.forename: G A
authors.initials: GA
authors.lastname: Riabov
authors.forename: S S
authors.initials: SS
authors.lastname: Ladygin
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Azizov
authors.forename: I N
authors.initials: IN
authors.lastname: Pasechnik
authors.forename: S I
authors.initials: SI
authors.lastname: Dorokhov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Skripkin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001774:Blood Chemical Analysis; D003422:Critical Care; D003911:Dextrans / Q000008:administration & dosage / Q000627:therapeutic use*; D004329:Droperidol / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology; D013514:Surgical Procedures, Operative; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D003911:Dextrans; D014665:Vasodilator Agents; D004329:Droperidol
vernacular_title: Korrektsiia narusheniĭ tkanevoĭ perfuzii u khirurgicheskikh bol'nykh v kritisheskikh sostoianiiakh i ikh otsenka po dinamike pokazateleĭ kislotorastvorimykh fraktsiĭ plazmy krovi.