title: Well-differentiated hepatocellular carcinoma associated with long-term survival. Report of two cases.
abstract: Two cases of well-differentiated hepatocellular carcinoma (HCC) with focal biliary differentiation are presented. The distinct histological features of these neoplasms and the unusually protracted clinical course of 8 and 10 years distinguish them from previously described pathological categories of primary hepatic tumors. Electron microscopic and immunohistochemical findings support a dual hepatic and bile duct differentiation of the tumor cells. If additional examples of this tumor are found to be associated with a similarly prolonged symptom-free survival, the distinction of this entity from traditional, rapidly fatal HCC becomes important. Less aggressive therapeutic options may be entertained.
authors.affiliation: Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts.
authors.forename: M
authors.initials: M
authors.lastname: Loda
authors.forename: A E
authors.initials: AE
authors.lastname: Mendoza
authors.forename: C
authors.initials: C
authors.lastname: O'Hara
authors.forename: J M
authors.initials: JM
authors.lastname: Crawford
authors.forename: M
authors.initials: M
authors.lastname: Federman
authors.forename: H
authors.initials: H
authors.lastname: Goodman
mesh_terms: D000328:Adult; D001652:Bile Ducts / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006063:Chorionic Gonadotropin / Q000378:metabolism; D002864:Chromogranins / Q000378:metabolism; D005260:Female; D006500:Hepatic Duct, Common / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D018396:Mucin-1; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D011379:Prognosis; D013997:Time Factors; D014746:Vimentin / Q000378:metabolism; D000514:alpha 1-Antichymotrypsin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism
chemical_list: D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D002864:Chromogranins; D008562:Membrane Glycoproteins; D018396:Mucin-1; D014746:Vimentin; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D007633:Keratins; D010751:Phosphopyruvate Hydratase