title: [49 day storage of erythrocyte concentrates in blood bags with the PAGGS-mannitol solution].
abstract: The red cell preservation solution PAGGS-Mannitol differs from the well documented PAGGS-Sorbitol only by the exchange from Sorbitol in Mannitol. In a clinical investigation with volunteers, up to 21 of the pure PAGGS-Mannitol solution were infused within 4 h. Blood and urine parameters were determined. The solution was well tolerated, no unexpected change of blood and urine parameters was found. The 24 h red cell in vivo survival rate of PAGGS-Mannitol was found to be 74.5 +/- 4.4%, after 49 days storage, a value which was described for PAGGS-Sorbitol before. In vitro data on storage of red cell concentrates with and without buffy coat were determined for hemolysis, 2,3-DPG and ATP using a blood bag system with DEHP and TOTM plastisized PVC. If 1% hemolysis is regarded as acceptable, red cell concentrates can be stored in PAGGS-Mannitol with a TOTM plastisized blood bag system up to 42 days. Under these conditions the amount of plastisizer in the red cell concentrate was found to be only 1% of the amount determined in a standard DEHP plastisized PVC blood bag system.
authors.affiliation: Biotrans GmbH, Dreieich.
authors.forename: W H
authors.initials: WH
authors.lastname: Walker
authors.forename: M
authors.initials: M
authors.lastname: Netz
authors.forename: K H
authors.initials: KH
authors.lastname: Gänshirt
mesh_terms: D000225:Adenine / Q000008:administration & dosage; D001793:Blood Preservation / Q000295:instrumentation / Q000379:methods*; D001803:Blood Transfusion / Q000295:instrumentation / Q000379:methods*; D004905:Erythrocyte Aging / Q000187:drug effects*; D017707:Erythrocyte Transfusion; D005947:Glucose / Q000008:administration & dosage; D006151:Guanosine / Q000008:administration & dosage; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008353:Mannitol / Q000008:administration & dosage*; D010710:Phosphates / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage; D013012:Sorbitol / Q000008:administration & dosage*
chemical_list: C053620:PAGGS-sorbitol solution; D010710:Phosphates; D006151:Guanosine; D008353:Mannitol; D012965:Sodium Chloride; D013012:Sorbitol; D005947:Glucose; D000225:Adenine
vernacular_title: 49 Tage Lagerung von Erythrozytenkonzentraten in Blutbeuteln mit der Konservierungslösung PAGGS-Mannitol.