Site of anti-inflammatory action of dexamethasone in rabbit skin.
Systemic pretreatment of rabbits with dexamethasone results in a time-dependent inhibition of oedema responses caused by intradermal injection of both 'direct-acting' and 'neutrophil-dependent' stimuli. Local injection of actinomycin D, an inhibitor of RNA synthesis, inhibits this effect. Our studies suggest that a major action of dexamethasone in this model may be a local inhibition of increased permeability of the vascular endothelium.
Peers
S H
SH
Pharmacology Group, University of Bath, Claverton Down, U.K.
Flower
R J
RJ
D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000188:drug therapy*; D003907:Dexamethasone / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology; D007975:Leukotriene B4 / Q000494:pharmacology; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis; D011817:Rabbits; D012867:Skin / Q000187:drug effects; D015054:Zymosan / Q000494:pharmacology
D010972:Platelet Activating Factor; D003609:Dactinomycin; D007975:Leukotriene B4; D009240:N-Formylmethionine Leucyl-Phenylalanine; D012313:RNA; D003907:Dexamethasone; D006632:Histamine; D015054:Zymosan; D015232:Dinoprostone; D001920:Bradykinin