Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsiveness.
A novel cell-cell recombination model was established to test the reciprocal mesenchymal (fibroblast)-epithelial interaction in the prostate gland. Both growth factors and ECM pathways were found to be actively engaged during cellular communications. The application of this cell-cell recombination concept to prostate cancer established a new human prostate cancer animal model in which the tumours actively secrete prostate specific antigen, a known human prostate cancer marker. This review explores the significance of mesenchymal-epithelial interaction in determining prostate hormonal responsiveness and prostate cell transformation and speculates on the potential roles of mesenchymal-epithelial interaction in prostate cancer growth and progression.
Chung
L W
LW
Urology Research Laboratory, University of Texas M D Anderson Cancer Center, Houston 77030.
Gleave
M E
ME
Hsieh
J T
JT
Hong
S J
SJ
Zhau
H E
HE
D000230:Adenocarcinoma / Q000503:physiopathology*; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002450:Cell Communication; D002455:Cell Division / Q000502:physiology; D004848:Epithelium / Q000502:physiology; D005260:Female; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000502:physiology; D051379:Mice; D009376:Neoplasms, Hormone-Dependent / Q000503:physiopathology*; D017430:Prostate-Specific Antigen / Q000502:physiology; D011471:Prostatic Neoplasms / Q000503:physiopathology*; D051381:Rats; D012513:Sarcoma, Experimental / Q000503:physiopathology*
D000728:Androgens; D006133:Growth Substances; D017430:Prostate-Specific Antigen