title: [Structural effects in the sarcolemma of the cardiomyocytes under the action of modulators of the polyphosphoinositide system].
abstract: The influence of activators (Ca(2+)-channels stimulator BAY K 8644 and phospholipase C stimulator fMLP) and inhibitors (Ca(2+)-channels blocker verapamil and alpha 1-adrenoceptors blocker prazosin) of the polyphosphoinositide system on cardiomyocytes sarcolemma, was studied. The structural effects of the PPI modifiers seem to be one of the mechanisms of the PPI physiological activity at the membrane level.
authors.forename: O I
authors.initials: OI
authors.lastname: Lebed'
authors.forename: V V
authors.initials: VV
authors.lastname: Zhirnov
authors.forename: N A
authors.initials: NA
authors.lastname: Zueva
authors.forename: B S
authors.initials: BS
authors.lastname: Braver-Chernobul'skaia
authors.forename: V G
authors.initials: VG
authors.lastname: Shevchuk
authors.forename: N A
authors.initials: NA
authors.lastname: Gorchakova
mesh_terms: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D005456:Fluorescent Dyes; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009206:Myocardium / Q000648:ultrastructure*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols / Q000037:antagonists & inhibitors / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D012508:Sarcolemma / Q000187:drug effects* / Q000648:ultrastructure; D014700:Verapamil / Q000494:pharmacology
chemical_list: D005456:Fluorescent Dyes; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D009240:N-Formylmethionine Leucyl-Phenylalanine; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D014700:Verapamil; D011224:Prazosin
vernacular_title: Strukturnye éffekty v sarkolemme kardiomiotsitov pri deĭstvii moduliatorov polifosfoinozitidnoĭ sistemy.