title: Ab initio investigations on the intermediates of RNA cleaving processes.
abstract: Ab initio molecular orbital calculations have been carried out on acyclic oxyphosphoranes in order to elucidate the origin of previously calculated energy differences of cyclic counterparts of RNA cleaving reactions. It appears that the orientation of the equatorial methoxyl group has pronounced effects in energy on the transition states than the metastable intermediates.
authors.affiliation: National Chemical Laboratory for Industry, Agency of Industrial Science & Technology, MITI, Tsukuba Science City, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Uchimaru
authors.forename: K
authors.initials: K
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Ucbayasi
authors.forename: S
authors.initials: S
authors.lastname: Nishikawa
authors.forename: K
authors.initials: K
authors.lastname: Taira
mesh_terms: D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry; D012313:RNA / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D009943:Organophosphorus Compounds; C070278:trimethoxyphosphorane; D012313:RNA