Facilitatory role of calcitonin gene-related peptide (CGRP) on excitation induced by substance P (SP) and noxious stimuli in rat spinal dorsal horn neurons. An iontophoretic study in vivo.
The effects of iontophoretically applied calcitonin gene-related peptide (CGRP) and/or substance P (SP) onto physiologically identified neurons in the rat lumbar dorsal horn were studied. The consistent excitatory effects of SP found on the spontaneous and the noxious evoked activity were significantly potentiated by CGRP application. This peptide facilitated the noxious evoked activity and did not affect the spontaneous activity of the neurons. The responses to non-noxious stimuli were unaffected in all cases.
Biella
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G
Istituto di Fisiopatologia e Terapia del Dolore, Università' di Milano, Italy.
Panara
C
C
Pecile
A
A
Sotgiu
M L
ML
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D007478:Iontophoresis; D008297:Male; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology*; D013373:Substance P / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide