Omeprazole in post-gastrocystoplasty metabolic alkalosis and aciduria.
The use of segments of stomach for bladder augmentation is gaining popularity in pediatric urology due to favorable muscular and secretory properties. However, in a renal failure patient who underwent gastrocystoplasty a high level of acid production within the bladder associated with persistent hypergastrinemia was noted leading to severe systemic metabolic alkalosis. This condition was unresponsive to standard acid-inhibiting or neutralizing therapies but it was treated successfully with omeprazole, a proton-pump inhibitor recently introduced for treatment of peptic ulcer disease.
Kinahan
T J
TJ
Department of Urology, Hospital for Sick Children, Toronto, Ontario, Canada.
Khoury
A E
AE
McLorie
G A
GA
Churchill
B M
BM
D000471:Alkalosis / Q000209:etiology*; D002675:Child, Preschool; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use*; D011183:Postoperative Complications; D013270:Stomach / Q000637:transplantation*; D001743:Urinary Bladder / Q000601:surgery*; D014556:Urine; D014718:Vesico-Ureteral Reflux / Q000601:surgery
D005755:Gastrins; D009853:Omeprazole