Treatment of infective endocarditis with granulocyte colony-stimulating factor.
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein hormone which stimulates the proliferation and differentiation of a subset of granulocyte precursors and enhances some functional activities of mature neutrophils. We tested the effects of G-CSF on a patient with intractable infective endocarditis. The white blood cell count was increased 3-fold and the inflammatory reactions such as C-reactive protein and erythrocyte sedimentation rate were completely normalized without any side effects. This is the first report describing the use of G-CSF for infective endocarditis. Administration of G-CSF might be suitable for treating intractable infections which cannot be controlled by antibiotics alone.
Hanazono
Y
Y
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Miyazono
K
K
Tsuchimochi
H
H
Yamaoki
K
K
Miyagawa
K
K
Hirai
H
H
Yazaki
Y
Y
Takaku
F
F
D000368:Aged; D000900:Anti-Bacterial Agents; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000097:blood / Q000188:drug therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count; D008297:Male
D000900:Anti-Bacterial Agents; D016179:Granulocyte Colony-Stimulating Factor; D002097:C-Reactive Protein