Inhibitory effect of tranilast on substance P-induced plasma extravasation in rat skin.
The effect of tranilast, an inhibitor for IgE-mediated mediator release from mast cells, on plasma extravasation induced by the intradermal injection of substance P in rats was examined. Tranilast (100 mg/kg, intraperitoneally) decreased plasma extravasation induced by substance P (10(-7)-10(-5) M). Tranilast decreased plasma extravasation induced by the amino-terminal peptide substance P1-9 (10(-6)-10(-4) M), which is active for rat mast cells, but not by the carboxy-terminal peptide substance P6-11 (10(-6)-10(-4) M), which is inactive for the mast cells. Therefore, tranilast prevents substance P-induced plasma extravasation most likely by inhibiting mast cell degranulation.
Iwamoto
I
I
Second Department of Internal Medicine, Chiba University School of Medicine, Japan.
Yamazaki
H
H
Tomioka
H
H
Yoshida
S
S
D000818:Animals; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D010949:Plasma / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000276:immunology; D013373:Substance P / Q000037:antagonists & inhibitors*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D006634:Histamine H1 Antagonists; D062367:ortho-Aminobenzoates; D013373:Substance P; C012293:tranilast