[Sensitivity of human squamous and adenoid cystic carcinoma cell lines with cisplatin and it's combined chemotherapy in vitro].
This was a report on the sensitivity of human squamous (Tca-8113) and adenoid cystic carcinoma (Acc-2) cell lines with Cisplatin (DDP) and it's combined chemotherapy (DDP+VCR+PYM, or PVP). DDP could kill both these two cell lines in vitro depending on the concentration of agent in given time. The rate of 3H-TdR incorporation, plating efficiency and DNA synthesis of carcinoma cells were prevented in drug-exposing groups. Tca-8113 cell line was more sensitive to DDP than Acc-2 cell line (P less than 0.01). PVP combined chemotherapy could enhance DDP's anticancer efficiency.
Cheng
X F
XF
School of Stomatology, Shanghai Second Medical University.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology / Q000031:analogs & derivatives; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002945:Cisplatin / Q000494:pharmacology*; D006801:Humans; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D014062:Tongue Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014750:Vincristine / Q000494:pharmacology
D001761:Bleomycin; D014750:Vincristine; C021771:zhengguangmycin; D002945:Cisplatin