title: Postoperative pain prevention by a single-dose formulation of diclofenac producing a steady plasma concentration.
abstract: The preoperative single-dose oral administration of a combination of rapid- and slow-release diclofenac (Voltaren, Ciba-Geigy, Basel, Switzerland) preparation in a placebo-controlled trial proved to be more effective in postoperative pain prevention following third molar removal than the combination of intramuscular diclofenac and an oral depot formula.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Hyrkäs
authors.forename: P
authors.initials: P
authors.lastname: Ylipaavalniemi
authors.forename: V J
authors.initials: VJ
authors.lastname: Oikarinen
authors.forename: G
authors.initials: G
authors.lastname: Hampf
mesh_terms: D000328:Adult; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004435:Eating; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008334:Mandible / Q000502:physiology; D008964:Molar, Third / Q000601:surgery; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010919:Placebos; D011292:Premedication; D014081:Tooth Extraction / Q000009:adverse effects
chemical_list: D003692:Delayed-Action Preparations; D010919:Placebos; D004008:Diclofenac