Time-course studies of immediate and delayed immune reactivity in patients with atopic dermatitis treated with herbal drugs.
We followed a number of in vitro parameters in nine adult patients with atopic dermatitis for a period of 3 weeks during which the patients took herbal drugs that are claimed to improve chronic eczema. The following investigations were performed weekly: blood leucocytes, circulating eosinophils, serum IgE, mitogen responsiveness of lymphocytes, interleukin 1 release, soluble interleukin 2 receptor levels in serum, and in vitro histamine release from basophils in blood. The study demonstrated increased levels of IgE in six patients, increased levels of soluble interleukin 2 receptor in six patients, and a significant correlation between the amount of IgE in serum and the maximal release of histamine from basophils in blood. In this open study five patients experienced a clinical worsening of their disease during the intake of herbal medicine. All other parameters were within normal levels. There was no significant change in the in vitro parameters during the observation period.
Søderberg
U
U
Department of Dermatology, University of Aarhus, Denmark.
Windelborg Nielsen
B
B
Schade Larsen
C
C
Schiøtz
P O
PO
Thestrup-Pedersen
K
K
D000293:Adolescent; D000328:Adult; D003876:Dermatitis, Atopic / Q000276:immunology / Q000628:therapy*; D004341:Drug Evaluation; D005260:Female; D006636:Histamine Release; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology / Q000628:therapy*; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007375:Interleukin-1 / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D015375:Receptors, Interleukin-2 / Q000032:analysis; D013997:Time Factors
D007375:Interleukin-1; D015375:Receptors, Interleukin-2; D007073:Immunoglobulin E