[Identification of a protective epitope--a fragment of Lassa virus nucleoprotein].
Several peptides from Lassa virus glyco- and nucleoproteins were predicted as probable T-cell epitopes. Their synthesis was performed by solid phase method. The study of possible protective effect in vivo with Lassa-sensitive CBA mice revealed protective epitope within the 277-303 nucleoprotein region. Further studies reduced the protective epitope structure to the 287-300 nucleoprotein fragment.
Moshnikova
A B
AB
Kozhich
A T
AT
Kras'ko
A G
AG
Chikin
L D
LD
Barkar
N D
ND
Ivanov
V T
VT
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral; D000939:Epitopes / Q000737:chemistry*; D007836:Lassa virus / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D009698:Nucleoproteins / Q000737:chemistry* / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology; D014764:Viral Proteins / Q000737:chemistry* / Q000235:genetics
D000956:Antigens, Viral; D000939:Epitopes; D009698:Nucleoproteins; D014764:Viral Proteins
Identifikatsiia protektivnogo épitope--fragmenta nukleoproteina virusa Lassa.