BHC induced testicular impairments in rats.
Benzene hexachloride (BHC) was fed to mature male rats weighing 160 g at dosages of 3 and 6 mg/kg body weight over a period of 180 days. Significant decrease in testicular weight and degeneration of seminiferous tubules with deformed spermatogenic cells were noted at a dose of 6 mg/kg BHC. Marked increase in BHC residue in testis revealed that the drug was able to cross blood-testis barrier.
Chowdhury
A R
AR
National Institute of Occupational Health, Meghani Nagar, Ahmedabad.
Gautam
A K
AK
D000818:Animals; D001814:Blood-Testis Barrier / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012671:Seminiferous Tubules / Q000473:pathology; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects; D013194:Staining and Labeling; D013733:Testicular Diseases / Q000139:chemically induced* / Q000473:pathology; D013737:Testis / Q000473:pathology
D001556:Hexachlorocyclohexane