Alcohol, the chloride ionophore and endogenous ligands for benzodiazepine receptors.
Considerable evidence suggests that at least some of the effects of ethanol are mediated by an action on the GABAA receptor chloride channel complex. More speculative is the suggestion that ethanol might interact with endogenous ligands for the benzodiazepine receptor on the complex. This paper considers the evidence for such interactions.
Lister
R G
RG
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
Linnoila
M
M
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D018118:Chloride Channels; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D008024:Ligands; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology*; D011963:Receptors, GABA-A / Q000187:drug effects / Q000502:physiology*
D018118:Chloride Channels; D007473:Ion Channels; D008024:Ligands; D008565:Membrane Proteins; D011963:Receptors, GABA-A; D000431:Ethanol