title: Cytokeratin intermediate filament pattern and human papillomavirus type in uterine cervical biopsies with different histological diagnosis.
abstract: The cytokeratin pattern and the presence of human papillomavirus (HPV) were analyzed in 53 uterine cervical biopsies. The biopsies were histologically characterized and the diagnosis ranged from normal through dysplasia to carcinoma. The cytokeratins were identified by their immunological reactivity with the monoclonal antibodies AE1 and AE3. The tissue was typed for the presence of HPV types 11, 16 and 18. We have previously shown that there was no correlation between the expression of cytokeratins No. 14, 15, 16 and 19 (K14, K15, K16 and K19) and the histological diagnosis of cervical biopsies. The present study shows that the cytokeratin pattern cannot be correlated to HPV infection of the cervical tissue either.
authors.affiliation: Institute of Medical Microbiology, University of Copenhagen, Denmark.
authors.forename: L N
authors.initials: LN
authors.lastname: Nielsen
authors.forename: U
authors.initials: U
authors.lastname: Hørding
authors.forename: S
authors.initials: S
authors.lastname: Daugaard
authors.forename: L P
authors.initials: LP
authors.lastname: Rasmussen
authors.forename: B
authors.initials: B
authors.lastname: Norrild
mesh_terms: D001345:Autoradiography; D002278:Carcinoma in Situ / Q000382:microbiology / Q000648:ultrastructure; D002294:Carcinoma, Squamous Cell / Q000382:microbiology / Q000648:ultrastructure; D002584:Cervix Uteri / Q000382:microbiology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007382:Intermediate Filaments / Q000648:ultrastructure*; D007633:Keratins / Q000032:analysis*; D027383:Papillomaviridae / Q000302:isolation & purification*; D002578:Uterine Cervical Dysplasia / Q000382:microbiology / Q000648:ultrastructure; D002583:Uterine Cervical Neoplasms / Q000382:microbiology* / Q000648:ultrastructure
chemical_list: D007633:Keratins