title: Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits.
abstract: The present study deals with the effects of immunomodulators on the morphology of intracerebral arterial walls in rabbits with experimental subarachnoid haemorrhage (SAH). Immunostimulators:thymostimuline and inosine dimethylamino-isopropanol-p-acetamido-benzoate were found to aggravate the angiopathic changes, whereas immunosuppressive drugs-cyclosporine A and azathioprine appeared to prevent the damage. The authors consider the possibility of using immunosuppressive drugs in patients with ruptured intracranial aneurysms.
authors.affiliation: Department of Neurophysiology, Medical Research Centre, Polish Academy of Sciences, Warsaw.
authors.forename: M
authors.initials: M
authors.lastname: Ryba
authors.forename: K
authors.initials: K
authors.lastname: Iwańska
authors.forename: M
authors.initials: M
authors.lastname: Walski
authors.forename: M
authors.initials: M
authors.lastname: Pastuszko
mesh_terms: D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use*; D002536:Cerebral Arteries / Q000187:drug effects* / Q000473:pathology; D003524:Cyclosporins / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D007542:Inosine Pranobex / Q000627:therapeutic use; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000473:pathology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000188:drug therapy*; D013949:Thymus Extracts / Q000627:therapeutic use
chemical_list: D003524:Cyclosporins; D013949:Thymus Extracts; C031407:thymostimulin; D001379:Azathioprine; D007542:Inosine Pranobex