Significance of human T-lymphotropic virus type I indeterminant serological findings among healthy individuals.
Follow-up studies on 67 blood donors with indeterminant serological findings for human T-lymphotropic virus (HTLV) type I by standard immunoassays showed no evidence of infection by polymerase chain reaction analysis for HTLV-I or HTLV-II nucleic acids or by antibody reactivity to a unique HTLV-I recombinant envelope protein, MTA-4. Among HTLV-I- or -II-infected individuals, a history of blood transfusion, past residence in established HTLV-I endemic areas or some association with intravenous drug use were common. In contrast, 85% of indeterminant cases had none of these risk factors. These observations suggest that healthy individuals with indeterminant serology for HTLV-I should not require additional studies.
Lipka
J J
JJ
Department of Pathology, Stanford University Medical Center, Calif.
Young
K K
KK
Kwok
S Y
SY
Reyes
G R
GR
Sninsky
J J
JJ
Foung
S K
SK
D000328:Adult; D001782:Blood Donors; D015153:Blotting, Western; D000939:Epitopes / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D015481:HTLV-I Antibodies / Q000097:blood; D015482:HTLV-II Antibodies / Q000097:blood; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015531:Radioimmunoprecipitation Assay
D000939:Epitopes; D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies