Neurokinin receptor-mediated regulation of [Ca]i and Ca-sensitive ion channels in mammalian colonic muscle.
In conclusion, these findings suggest the following: (1) NK receptor activation results in [Ca2+]i oscillations; (2) the receptor-mediated [Ca2+]i increase is partially due to influx of Ca2+ through L-type Ca2+ channels and partially to release from intracellular stores; (3) the receptor-mediated depolarization results from activation of a Cl- channel at the cell resting potential; (4) NK receptor-mediated release of [Ca2+]i may play a role in Cl- channel activation; (5) there is no evidence for multiple NK receptor types involved in cell activation.
Mayer
E A
EA
Department of Medicine, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073.
Sun
X P
XP
Supplisson
S
S
Kodner
A
A
Regoli
M
M
Sachs
G
G
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D003106:Colon / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D015288:Neurokinin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology*; D018039:Receptors, Tachykinin; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology
D015220:Calcium Channels; D010446:Peptide Fragments; D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; C062618:substance P, Sar(9)-Met(O2)(11)-; C064218:neurokinin A (4-10), beta-Ala(8)-; D013373:Substance P; D000001:Calcimycin; D015288:Neurokinin A; D002118:Calcium