title: Upper vaginectomy for in situ and occult, superficially invasive carcinoma of the vagina.
abstract: Between Aug. 1, 1985, and July 31, 1990, 32 patients underwent upper vaginectomy for grade 3 vaginal intraepithelial neoplasia. Thirty-one of these patients had undergone hysterectomy, 25 because of cervical neoplasia. Fourteen patients had undergone treatment for vaginal intraepithelial neoplasia. Nine (28%) had invasive cancer on final pathologic examination. Among the remaining 23 patients, recurrence of vaginal neoplasia developed in four (17%), with a mean time to recurrence of 78 weeks, and one was found to have superficial invasion at the time of recurrence. The remaining 19 patients remain alive with no evidence of recurrent disease at a mean follow-up interval of 152 weeks. In our patients upper vaginectomy was efficacious for the diagnosis of occult invasive carcinoma of the vagina and for the treatment of in situ and superficially invasive carcinoma of the vagina.
authors.affiliation: Department of Obstetrics and Gynecology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612-9497.
authors.forename: M S
authors.initials: MS
authors.lastname: Hoffman
authors.forename: S L
authors.initials: SL
authors.lastname: DeCesare
authors.forename: W S
authors.initials: WS
authors.lastname: Roberts
authors.forename: J V
authors.initials: JV
authors.lastname: Fiorica
authors.forename: M A
authors.initials: MA
authors.lastname: Finan
authors.forename: D
authors.initials: D
authors.lastname: Cavanagh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000532:radiotherapy / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery; D014621:Vagina / Q000601:surgery*; D014625:Vaginal Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery*