Histochemically demonstrable phosphotyrosine protein phosphatase in the rat hippocampal formation.
Using o-phospho-L-tyrosine as substrate, a possible localization of phosphotyrosine protein phosphatase (PTPPase) activity was histochemically demonstrated in the rat hippocampal formation. The PTPPase activity was found in almost all layers of the hippocampal formation, with a high activity in the stratum moleculare. The activity was inhibited by vanadate and molybdate, but not by NaF and Zn2+. The activity was localized in the dendritic cytoplasm, particularly on the postsynaptic density, of hippocampal neurons.
Yoshioka
T
T
Department of Anatomy, Shimane Medical University, Izumo, Japan.
Tanaka
O
O
Otani
H
H
Shinohara
H
H
D000818:Animals; D003593:Cytoplasm / Q000201:enzymology; D003712:Dendrites / Q000201:enzymology; D006624:Hippocampus / Q000166:cytology / Q000201:enzymology*; D006651:Histocytochemistry; D008297:Male; D008854:Microscopy, Electron; D019000:Phosphotyrosine; D017027:Protein Tyrosine Phosphatases / Q000032:analysis* / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D014443:Tyrosine / Q000031:analogs & derivatives / Q000378:metabolism
D019000:Phosphotyrosine; D014443:Tyrosine; D017027:Protein Tyrosine Phosphatases