Fetal olfactory bulb transplants send projections to host olfactory cortex in the rat.
We are using the rat olfactory system to study developmental details of neurotransplantation. Tritiated [3H]thymidine-labeled fetal olfactory bulbs (OBs), were transplanted immediately into sites from which the neonatal host OB was removed. Subsequently, a small lesion was placed in the region of the transplanted OB and the tissue studied, using degeneration methods and autoradiography. Only OB's with extensive [3H]-label and precise lesions confined to the labeled areas were used. Degeneration was found mainly in the ipsilateral piriform cortex with lesser amounts at other nearby sites. The results demonstrate successfully transplanted donor OBs that send axons to specific and appropriate target areas of the host brain.
Westrum
L E
LE
Department of Neurological Surgery, University of Washington, School of Medicine and Dentistry, Seattle 98195.
Kott
J N
JN
Vickland
H
H
Hankin
M H
MH
Lund
R D
RD
D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000473:pathology / Q000502:physiology*; D016332:Fetal Tissue Transplantation; D009410:Nerve Degeneration; D009830:Olfactory Bulb / Q000502:physiology*; D009833:Olfactory Pathways / Q000473:pathology / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling; D009435:Synaptic Transmission