Neurobiology of parasitic platyhelminths: possible solutions to the problems of correlating structure with function.
This paper provides an overview of research on the nervous system of parasitic platyhelminths. We have emphasized studies concerned with the physiological, pharmacological and biochemical nature of the major small molecule neurotransmitters of these parasites. We have attempted to provide a critical review of the work by focusing on important unresolved issues. Finally, we have focused on some recent work in our laboratory, using patch-clamp recording techniques and quantitative fluorescence cytometry, as an example of newer methods that will hopefully resolve some of the unanswered questions concerning the nervous system of these parasites.
Pax
R A
RA
Department of Pharmacology, Michigan State University, East Lansing 48824.
Bennett
J L
JL
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002589:Cestoda / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D005210:Fasciola hepatica / Q000502:physiology; D007473:Ion Channels; D008297:Male; D009132:Muscles / Q000502:physiology; D009424:Nervous System Physiological Phenomena; D009446:Neurobiology; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000502:physiology*; D012550:Schistosoma mansoni / Q000502:physiology; D015290:Second Messenger Systems; D012701:Serotonin / Q000502:physiology; D014200:Trematoda / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*
D007473:Ion Channels; D018377:Neurotransmitter Agents; D012701:Serotonin; D000109:Acetylcholine