title: Possible role of aphidicolin-sensitive DNA polymerase(s) in N-methyl-N'-nitro-N-nitrosoguanidine and bleomycin induced cellular repair synthesis and virus reactivation.
abstract: Treatment of human embryonic cell line CLV 102 with N-methyl-N'-nitro-N-nitrosoguanidine or bleomycin was used to induce DNA repair synthesis. Both the repair synthesis induced by these agents and reactivation of UV-damaged pseudorabies virus were inhibited by aphidicolin.
authors.affiliation: Serum and Vaccines Research Laboratories, Warszawa, Poland.
authors.forename: N
authors.initials: N
authors.lastname: Mazurowa
authors.forename: E
authors.initials: E
authors.lastname: Anuszewska
authors.forename: J
authors.initials: J
authors.lastname: Koziorowska
mesh_terms: D016590:Aphidicolin / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D002460:Cell Line; D004260:DNA Repair / Q000187:drug effects*; D004259:DNA-Directed DNA Polymerase / Q000187:drug effects / Q000502:physiology*; D011558:Herpesvirus 1, Suid / Q000254:growth & development / Q000528:radiation effects; D006801:Humans; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D014466:Ultraviolet Rays; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D001761:Bleomycin; D008769:Methylnitronitrosoguanidine; D016590:Aphidicolin; D004259:DNA-Directed DNA Polymerase