Thyroid cell lines in research on goitrogenesis.
Thyroid cell lines have contributed a lot to the understanding of goitrogenesis. The cell lines mostly used in thyroid research are briefly discussed, namely the rat thyroid cell lines FRTL and FRTL-5, the porcine thyroid cell lines PORTHOS and ARTHOS, The sheep thyroid cell lines OVNIS 5H and 6H, the cat thyroid cell lines PETCAT 1 to 4 and ROMCAT, and the human thyroid cell lines FTC-133 and HTh 74. Chinese hamster ovary (CHO) cells and COS-7 cells, stably transfected with TSH receptor cDNA and expressing a functional TSH receptor, are discussed as examples for non-thyroidal cells, transfected with thyroid genes.
Gerber
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H
Laboratory of Experimental Endocrinology, University Clinic of Medicine, Inselspital, Berne, Switzerland.
Peter
H J
HJ
Asmis
L
L
Studer
H
H
D000818:Animals; D002460:Cell Line; D006042:Goiter / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D011989:Receptors, Thyrotropin / Q000235:genetics; D014162:Transfection
D011989:Receptors, Thyrotropin