title: c-src structure in human cancers with elevated pp60c-src activity.
abstract: We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-specific kinase activity found in a number of human cancer types.
authors.affiliation: Department of Medicine, State University of New York, Stony Brook 11794.
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Fromowitz
authors.forename: M
authors.initials: M
authors.lastname: Koslow
authors.forename: N
authors.initials: N
authors.lastname: Hagag
authors.forename: B
authors.initials: B
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Viola
mesh_terms: D001483:Base Sequence; D003062:Codon; D016391:Genes, src; D006801:Humans; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D009838:Oligodeoxyribonucleotides; D012150:Polymorphism, Restriction Fragment Length; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D003062:Codon; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases; D016392:Proto-Oncogene Proteins pp60(c-src)