Purification of a 50- to 58-kDa immunophilin from human spleen and a Jurkat T-cell line capable of binding cyclosporine A, FK 506, and rapamycin.
Donnelly
J G
JG
Department of Laboratory Medicine, Children's National Medical Center, Washington, DC 20100.
Soldin
S J
SJ
D001667:Binding, Competitive; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002460:Cell Line; D002850:Chromatography, Gel; D016572:Cyclosporine / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism*; D007700:Kinetics; D008970:Molecular Weight; D011090:Polyenes / Q000378:metabolism*; D020123:Sirolimus; D013154:Spleen / Q000502:physiology*; D016559:Tacrolimus / Q000378:metabolism*
D002352:Carrier Proteins; D007166:Immunosuppressive Agents; D011090:Polyenes; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus