Bypass by an alternate 'carrier' of acquired unresponsiveness to hCG upon repeated immunization with tetanus-conjugated vaccine.
We report here the use of an alternative carrier diphtheria toxoid (DT) in human subjects to overcome antigen-specific unresponsiveness upon immunization with a hapten/ligand-carrier conjugate. In the phase I clinical trial of a birth control vaccine using gonadotrophin subunits linked to tetanus toxoid, some of the subjects failed to evoke a booster antibody response to human chorionic gonadotrophin (hCG). Presentation of the ligand on DT instead in subsequent immunizations restored anti-hCG response.
Gaur
A
A
National Institute of Immunology, New Delhi, India.
Arunan
K
K
Singh
O
O
Talwar
G P
GP
D000917:Antibody Formation; D006063:Chorionic Gonadotropin / Q000276:immunology*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004167:Diphtheria Toxin / Q000276:immunology; D004337:Drug Carriers; D005260:Female; D006241:Haptens / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary; D010446:Peptide Fragments / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology*; D014611:Vaccination
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004167:Diphtheria Toxin; D004337:Drug Carriers; D006241:Haptens; D010446:Peptide Fragments; D013745:Tetanus Toxoid