Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population.
In this study of 221 lung cancer patients and 212 controls, no association between a Msp I polymorphism in the CYP1A1 gene and an increased risk of lung cancer was found. Histological type, smoking habits and family history were also examined. No associations between the Msp I restriction fragment length polymorphism in the CYP1A1 gene and any of these parameters were found. These results are in contrast to a previous report by a Japanese group (Kawajiri et al., 1990) who found an association between the less common allele and an increased susceptibility to lung cancer in their population. The frequency of the less common Msp I 1.9 kb fragment allele (C2) appears to be three times greater in the Japanese population than in the Norwegian population and a Caucasian population of North America. It is possible that in the Asian population this Msp I polymorphism is in linkage disequilibrium with another mutation important for CYP1A1 gene expression, whereas in the Caucasian population these mutations are in equilibrium.
Tefre
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T
Department of Genetics, Norwegian Radium Hospital, Montebello, Oslo.
Ryberg
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D
Haugen
A
A
Nebert
D W
DW
Skaug
V
V
Brøgger
A
A
Børresen
A L
AL
D000230:Adenocarcinoma / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015139:Blotting, Southern; D002277:Carcinoma / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D018288:Carcinoma, Small Cell / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D015342:DNA Probes; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D012907:Smoking
D015342:DNA Probes; D004247:DNA; D003577:Cytochrome P-450 Enzyme System; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific