title: Pulmonary blastoma with germ cell (yolk sac) differentiation: report of two cases.
abstract: Pulmonary blastoma is a rare lung neoplasm of disputed histogenesis and variable biologic behavior. Typical cases contain both epithelial and mesenchymal tissues, and a variety of patterns of differentiation have been described. While expression of oncofetal antigens in these tumors has been noted rarely, a coexisting component of germ cell tumor has not been reported previously. We describe the clinical and pathologic features of two cases of pulmonary blastoma having alpha-fetoprotein production and histologic areas of yolk sac tumor. We also report the finding of immunohistochemical staining of fetal lung tissue for alpha-fetoprotein.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: R J
authors.initials: RJ
authors.lastname: Siegel
authors.forename: C
authors.initials: C
authors.lastname: Bueso-Ramos
authors.forename: C
authors.initials: C
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Koss
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000737:chemistry / Q000196:embryology / Q000473:pathology; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology*; D008649:Mesonephroma / Q000737:chemistry / Q000473:pathology*; D013724:Teratoma / Q000737:chemistry / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins