Adverse cutaneous reactions due to macrolides.
Macrolides, which are widely prescribed and seldom produce hypersensitivity reactions, are considered to be safe drugs. We present five patients with generalized skin reactions due to erythromycin and/or spiramycin, proved by oral challenge tests. One patient showed reactions to both erythromycin and spiramycin. All skin prick and patch tests and histamine release tests with both macrolides were negative.
Igea
J M
JM
Servicio de Alergia, Hospital Ramon y Cajal, Carretera de Colmenar, Madrid, Spain.
Quirce
S
S
de la Hoz
B
B
Fraj
J
J
Pola
J
J
Diez Gomez
M L
ML
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D004917:Erythromycin / Q000009:adverse effects / Q000494:pharmacology; D005260:Female; D006636:Histamine Release / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D012879:Skin Physiological Phenomena; D012882:Skin Tests; D015572:Spiramycin / Q000009:adverse effects / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007073:Immunoglobulin E; D004917:Erythromycin; D015572:Spiramycin