Synthesis of the trisaccharide, 2-(p-trifluoroacetamidophenyl)ethyl O-alpha-D-galactopyranosyl-(1-4)-O-beta-D-galactopyranosyl-(1-4)-2-acet amido-2-deoxy-beta-D-glucopyranoside, corresponding to the blood group P1 determinant.
The 2-(p-trifluoroacetamidophenyl)ethyl beta-glycoside of the P1 antigen trisaccharide, O-alpha-D-galactopyranosyl-(1-4)-O-beta-D-galactopyranosyl-(1-4)-2- acetamido-2-deoxy-D-glucopyranose, was synthesized. Thioglycoside intermediates were used as building blocks.
Nilsson
S
S
Organic Synthesis Department, BioCarb AB, Lund, Sweden.
Lönn
H
H
Norberg
T
T
D002240:Carbohydrate Sequence; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010127:P Blood-Group System / Q000276:immunology*; D014312:Trisaccharides / Q000138:chemical synthesis*
D000939:Epitopes; D010127:P Blood-Group System; D014312:Trisaccharides; C076394:2-(p-trifluoroacetamidophenyl)ethyl O-galactopyranosyl-(1-4)-O-galactopyranosyl-(1-4)-2-acetamido-2-deoxy-glucopyranoside