The impact of marrow transplant preparative regimens on subsequent growth and development. The Seattle Marrow Transplant Team.
These data demonstrate that endocrine function abnormalities influencing subsequent growth and development in children after marrow transplantation rarely occur after preparation with CY alone. However, after administration of regimens containing TBI, multiple endocrine function abnormalities can occur. Although longer follow-up is needed, it appears that the addition of BU to CY does not result in thyroid function or growth abnormalities. Pubertal development and gonadal function, however, may be adversely influenced by BU and patients may require supplementation with appropriate gonadal hormones.
Sanders
J E
JE
Clinical Research Division, Fred Hutchinson Cancer Research Center 98104.
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000379:methods*; D002066:Busulfan / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D002658:Developmental Disabilities / Q000139:chemically induced*; D005260:Female; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006130:Growth Disorders / Q000139:chemically induced*; D006801:Humans; D008297:Male; D011628:Puberty, Delayed / Q000139:chemically induced; D014916:Whole-Body Irradiation
D003520:Cyclophosphamide; D002066:Busulfan