title: Immunohistochemical demonstration of alphaB-crystallin in hamartomas of tuberous sclerosis.
abstract: Autopsy material from two individuals with tuberous sclerosis were examined immunohistochemically for the expression of alpha B-crystallin. Positive immunoreactions were detected in the hamartomas of various organs. Abnormal expression of alpha B-crystallin in the hamartomas in conjunction with the alpha B-crystallin gene locus on chromosome 11q22-23 overlapping with one of the candidates of tuberous sclerosis loci suggest that tuberous sclerosis may involve the altered regulation of alpha B-crystallin gene expression.
authors.affiliation: Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwaki
authors.forename: J
authors.initials: J
authors.lastname: Tateishi
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D002648:Child; D003459:Crystallins / Q000032:analysis*; D005260:Female; D006222:Hamartoma / Q000737:chemistry* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D013194:Staining and Labeling; D014402:Tuberous Sclerosis / Q000150:complications* / Q000378:metabolism / Q000473:pathology
chemical_list: D003459:Crystallins