[The influence of intratracheal bleomycin instillation on peroxidative processes in rat lung tissue].
The influence of intratracheally instilled bleomycin (10 mg x kg-1) on antioxidant enzyme activity as well as on lipid peroxidation product levels after 7 and 14 days from drug administration in rat lungs was investigated. The 200-400% increase in superoxide dismutase, glutathione peroxidase, glutathione reductase, catalase and glucose-6-phosphate dehydrogenase activities were observed, as compared to control group. The levels of malondialdehyde, conjugated dienes and lipid hydroperoxides in lung tissue of bleomycin-treated rats were also higher than those in control group. These phenomena are the signs of adaptative mechanisms induction in lungs, protecting the tissue from dangerous effect of bleomycin-generated free radicals.
Ledwozyw
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Zakład Patofizjologii Wydziału Weterynaryjnego Akademii Rolniczej, Lublinie.
Ruciński
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Synowiec
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D000222:Adaptation, Physiological; D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage*; D002374:Catalase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D012016:Reference Values; D013482:Superoxide Dismutase / Q000378:metabolism; D014132:Trachea
D001761:Bleomycin; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
Wpływ dotchawiczego podania bleomycyny na procesy peroksydacyjne w tkance płuc szczurów.