Resistance to outflow of cerebrospinal fluid after central infusions of angiotensin.
Infusions of artificial cerebrospinal fluid (CSF) into the cerebroventricles of conscious rats can raise CSF pressure (CSFp). This response can be modified by some neuropeptides. One of these, angiotensin, facilitates the rise in CSFp. We measured CSFp in conscious rats with a computerized system and evaluated resistance to CSF outflow during infusion of artificial CSF, with or without angiotensin, from the decay kinetics of superimposed bolus injections. Angiotensin (10 ng/min) raised CSFp (P less than 0.05) compared with solvent, but the resistance to CSF outflow of the two groups was similar (P greater than 0.05). Because CSFp was increased by angiotensin without an increase in the outflow resistance, a change in some volume compartment is likely. Angiotensin may raise CSFp by increasing CSF synthesis; this possibility is supported, since the choroid plexuses contain an intrinsic isorenin-angiotensin system. Alternatively, angiotensin may dilate pial arteries, leading to an increased intracranial blood volume.
Morrow
B A
BA
Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey 17033.
Keil
L C
LC
Severs
W B
WB
D000704:Analysis of Variance; D000804:Angiotensin II / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D002555:Cerebrospinal Fluid / Q000187:drug effects / Q000502:physiology*; D007263:Infusions, Parenteral; D008297:Male; D011312:Pressure; D051381:Rats; D011919:Rats, Inbred Strains
D000804:Angiotensin II