Immunohistochemical localization of the alpha 1, alpha 2 and alpha 3 subunit of the GABAA receptor in the rat brain.
The immunohistochemical distribution of the alpha 1, alpha 2 and alpha 3 subunit of the gamma-aminobutyric acid-A (GABAA) receptor was investigated in the rat brain using affinity-purified antibodies against unique parts of the amino acid sequence of the respective subunits. The distribution of the 3 subunits differed markedly from each other indicating heterogeneity of the GABAA-receptor composition in different brain regions and at various receptive compartments (dendrites or somata) of neuronal cells.
Zimprich
F
F
Research Unit for Experimental Neuropathology, Austrian Academy of Sciences, Vienna.
Zezula
J
J
Sieghart
W
W
Lassmann
H
H
D000818:Animals; D001921:Brain / Q000378:metabolism*; D007150:Immunohistochemistry; D051381:Rats; D011919:Rats, Inbred Strains; D011963:Receptors, GABA-A / Q000378:metabolism*; D013194:Staining and Labeling; D014018:Tissue Distribution
D011963:Receptors, GABA-A