Modified lymphocyte response to mitogens induced by the lipopeptide fragment derived from Mycobacterium avium serovar-specific glycopeptidolipids.
The beta-elimination procedure was used to obtain two major fragments of Mycobacterium avium glycopeptidolipid antigens. The lipopeptide fragment, not the oligosaccharide, diminished the mitogen-induced blastogenic response of spleen cells at concentrations lower than those which affected viability. Electron microscopy revealed an internalization of lipopeptide and disruption of intracellular organization.
Tassell
S K
SK
Department of Microbiology and Immunology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.
Pourshafie
M
M
Wright
E L
EL
Richmond
M G
MG
Barrow
W W
WW
D000818:Animals; D005260:Female; D006020:Glycopeptides / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008055:Lipids / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009162:Mycobacterium avium / Q000737:chemistry* / Q000276:immunology; D009844:Oligosaccharides / Q000494:pharmacology; D013329:Structure-Activity Relationship
D006020:Glycopeptides; D007166:Immunosuppressive Agents; D008055:Lipids; D009844:Oligosaccharides