[Proto-oncogene expression in the liver of male rats of different age].
The expression of 10 protooncogenes has been quantitatively studied in liver of male rats L10 age of 1, 10.5, 22 and 37 months. It was shown that a number of specific mRNA transcripts and, therefore, the levels of expression of protooncogenes C-MYC, C-FOS, N-MYC, HA-RAS, KI-RAS, SIS, ABL, YES, MOS and MET in rat liver were constant during life span. These data are in accordance with resistance of the rat strain L10 to spontaneous hepatocarcinogenesis.
Novikov
L B
LB
Balanskiĭ
R M
RM
Anisimov
V N
VN
Khanson
K P
KP
D000367:Age Factors; D000818:Animals; D015342:DNA Probes; D015870:Gene Expression; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000235:genetics; D008297:Male; D009693:Nucleic Acid Hybridization; D011519:Proto-Oncogenes / Q000235:genetics*; D012313:RNA; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D014158:Transcription, Genetic
D015342:DNA Probes; D012333:RNA, Messenger; D012313:RNA
Ekspressiia protoonkogenov v pecheni samtsov krys raznogo vozrasta.