Response of young rats to repeated oral administration of technical hexachlorocyclohexane.
Male and Female young rats given daily po doses of technical hexachlorocyclohexane (HCH) (5 or 25 mg/kg) for 90 d showed male rats more susceptible to HCH than female. Percent mortality and enzymatic changes were more pronounced in the male rat than in the female. The accumulation of residues in the vital organs of male rat was relatively more than that of the female rat.
Dikshith
T S
TS
Pesticide Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
Srivastava
M K
MK
Raizada
R B
RB
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000032:analysis; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis; D004334:Drug Administration Schedule; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D007441:Intubation, Gastrointestinal; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D010573:Pesticide Residues / Q000032:analysis*; D051381:Rats; D012727:Sex Characteristics
D010573:Pesticide Residues; D001556:Hexachlorocyclohexane; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase