title: Effects of lindane on fluidity and lipid composition in rat renal cortex membranes.
abstract: The influence of lindane upon dynamic properties of plasma membranes from rat renal cortex has been investigated using a fluorescence polarization technique. Preincubation with lindane increased membrane fluidity in a manner that is dose-dependent. This increase was higher in brush border membranes than in basolateral membranes. However, a significant decrease of the membrane fluidity was found in brush border membranes when rats were injected with lindane for 12 days. A possible solution to this difference could involve a resistance to membrane disordering by lindane through a regulatory mechanism that would balance the amount of cholesterol and phospholipid classes in the renal cortex membranes of lindane-injected rats.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares-Madrid, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Pérez-Albarsanz
authors.forename: P
authors.initials: P
authors.lastname: López-Aparicio
authors.forename: S
authors.initials: S
authors.lastname: Senar
authors.forename: M N
authors.initials: MN
authors.lastname: Recio
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects*; D002784:Cholesterol / Q000032:analysis; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D005454:Fluorescence Polarization; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D007672:Kidney Cortex / Q000187:drug effects* / Q000648:ultrastructure; D007700:Kinetics; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D008563:Membrane Lipids; D010743:Phospholipids; D001556:Hexachlorocyclohexane; D002784:Cholesterol; D000469:Alkaline Phosphatase; D000254:Sodium-Potassium-Exchanging ATPase; D004121:Dimethyl Sulfoxide