title: The N terminal region of human tau is present in Alzheimer's disease protein A68 and is incorporated into paired helical filaments.
abstract: Antibody (Ab) E-1 was raised to the amino terminus (19 to 33 amino acid residues) of human tau. It recognized Alzheimer's disease proteins A68 (MW 60, 64, 68 kd), labeled paired helical filaments, and had no reactivity with tau from rat, mouse, and bovine brains. The results indicate that the N terminus of tau is incorporated in A68 proteins and paired helical filaments and that human tau proteins contain species-specific amino acid sequences.
authors.affiliation: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461.
authors.forename: A
authors.initials: A
authors.lastname: Crowe
authors.forename: H
authors.initials: H
authors.lastname: Ksiezak-Reding
authors.forename: W K
authors.initials: WK
authors.lastname: Liu
authors.forename: D W
authors.initials: DW
authors.lastname: Dickson
authors.forename: S H
authors.initials: SH
authors.lastname: Yen
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000918:Antibody Specificity; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D002417:Cattle; D000939:Epitopes; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D051379:Mice; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D016874:Neurofibrillary Tangles / Q000276:immunology; D051381:Rats; D016875:tau Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D007106:Immune Sera; C054369:MAPT protein, human; C489131:Mapt protein, rat; D009419:Nerve Tissue Proteins; D016875:tau Proteins