title: Iron, copper, and zinc status in rats fed supplemental nickel.
abstract: Literature data concerning the effect of increasing dietary Ni concentrations on Fe, Cu, and Zn status in rats are sparse and, in part, controversial. Therefore, the effects of the addition of either 0, 3, 50, or 100 mg Ni/kg diet on Fe, Cu, and Zn status of rats were investigated in two separate experiments. Purified diets were used that were composed according to the established nutrient requirements of rats. Ni in kidney was increased with increasing Ni intakes. Dietary Ni did not significantly influence Fe concentrations in plasma, liver, kidney, femur, and spleen. Likewise, the addition of Ni to the diet did not alter Cu status. Zn concentrations in femur were significantly decreased after feeding the diets with 100 mg Ni/kg. However, Zn in plasma, liver, kidney, and spleen was not affected. It is concluded that variations in dietary Ni concentrations have no major impact on Fe, Cu, and Zn status in rats.
authors.affiliation: Department of Human Nutrition, Agricultural University, Wageningen, The Netherlands.
authors.forename: J S
authors.initials: JS
authors.lastname: Oosting
authors.forename: A G
authors.initials: AG
authors.lastname: Lemmens
authors.forename: G J
authors.initials: GJ
authors.lastname: Van den Berg
authors.forename: A C
authors.initials: AC
authors.lastname: Beynen
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000378:metabolism* / Q000493:pharmacokinetics; D004032:Diet; D004435:Eating; D004906:Erythrocyte Count / Q000187:drug effects; D005527:Food, Fortified; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000097:blood / Q000378:metabolism* / Q000493:pharmacokinetics; D008297:Male; D009532:Nickel / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D015032:Zinc / Q000378:metabolism* / Q000493:pharmacokinetics
chemical_list: D006454:Hemoglobins; D003300:Copper; D009532:Nickel; D007501:Iron; D015032:Zinc