Development of murine B cell subpopulations.
The generation of diverse B cell subpopulations in the mouse is the subject of considerable current interest. In this review, I first describe a general framework for antigen-independent B cell differentiation in the adult bone marrow including results from in vitro culture systems. In following sections, effects on B cell development in several immunodeficient strains and transgenic lines are presented. Next, the CD5+ B cell subpopulation is covered in some depth, including data on development, physiology and repertoire selection. Finally, another selected population, memory B cells, together with their likely origins in the germinal center are discussed.
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I.C.R., Fox Chase Cancer Center, Philadelphia, PA 19111.
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D001854:Bone Marrow Cells; D018956:CD5 Antigens; D015870:Gene Expression; D015322:Gene Rearrangement, B-Lymphocyte; D006410:Hematopoiesis / Q000276:immunology*; D007156:Immunologic Memory; D051379:Mice
D015703:Antigens, CD; D018956:CD5 Antigens