Promotion of radiation-induced liver neoplasia by ethanol.
The risk of americium-induced liver cancer in beagle dogs that received long-term dietary ethanol was two to three times that of their nonalcoholic cohorts, even though the radionuclide retention time in hepatic tissue was shortened by the alcohol treatment. Liver malignancies did not occur in the ethanol-treated, nonirradiated controls. An ethanol-induced tumor-promoting effect was not observed in organs or tissues other than the liver.
Taylor
G N
GN
Radiobiology Division, University of Utah, Salt Lake City 84112.
Lloyd
R D
RD
Mays
C W
CW
Shabestari
L
L
Miller
S C
SC
D000576:Americium; D000818:Animals; D002273:Carcinogens; D004285:Dogs; D000431:Ethanol; D005260:Female; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*
D002273:Carcinogens; D000431:Ethanol; D000576:Americium