title: [Physiopathology of migraine].
abstract: The basic theories on the origin of migraine are reviewed. A vascular paroxysm was the initial hypothesis, followed by the "spreading depression" phenomenon based of regional flow studies of Danish authors. A third hypothesis relates the origin of migraine to liberation of substance "p" and others (K, neurotransmitters and polypeptides) from trigeminal nerve endings. Finally, a behavioral disturbance originating an adrenergic response and a loss of central nervous system defense mechanisms, has been also postulated.
authors.affiliation: Hospital Militar, Santiago de Chile.
authors.forename: S
authors.initials: S
authors.lastname: Ferrer
mesh_terms: D002560:Cerebrovascular Circulation; D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*; D013373:Substance P / Q000378:metabolism; D014276:Trigeminal Nerve / Q000502:physiology
chemical_list: D013373:Substance P
vernacular_title: Fisiopatología de la migraña.