[Effects of tumor necrosis factor on the tonus of cerebral arteries].
It was determined that tumor necrosis factor (TNF) is capable of decreasing the local brain's blood flow on 45.6% (in the concentration of 6 micrograms/kg); to make a spasm of the pial arteries on 39.6%. In vitro experiments TNF increased the amplitude of the rhythmical and the tonic contractions of the brain's arteries smooth muscles (3.6 X 10(-8) M). The direct action of the TNF in the vascular wall is endothelium-dependent.
Azin
A L
AL
Mitagvariia
N P
NP
Medvedev
V G
VG
Baratashvili
I K
IK
Barybin
A S
AS
D000818:Animals; D002536:Cerebral Arteries / Q000187:drug effects*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009389:Neovascularization, Pathologic; D010841:Pia Mater / Q000098:blood supply; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D014409:Tumor Necrosis Factor-alpha
Vliianie tumornekrotiziruiushchego faktora na tonus arteriĭ golovnogo mozga.