title: New approaches to the chemotherapy of melanoma.
abstract: Several new investigational agents have shown some promise in the treatment of patients with disseminated melanoma. While earlier studies of combination chemotherapy led to increased toxicity without improved anti-tumor effect, more recent combination regimens have produced responses up to 50%. One of these is a dose-intensification regimen using high-dose cisplatin and the chemoprotective drug WR-2721. Other treatments under study include autologous bone marrow transplantation plus thiotepa, a combination regimen of chemotherapy and interferon, and newer agents such as taxol, tauromustine, and detrorubicin.
authors.affiliation: Presbyterian Medical Center, Philadelphia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Glover
mesh_terms: D000470:Alkaloids / Q000009:adverse effects / Q000627:therapeutic use; D004999:Amifostine / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D002330:Carmustine / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage; D008545:Melanoma / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D009607:Nitrosourea Compounds / Q000627:therapeutic use; D017239:Paclitaxel; D011344:Procarbazine / Q000008:administration & dosage; D013629:Tamoxifen / Q000008:administration & dosage; D013654:Taurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D013852:Thiotepa / Q000627:therapeutic use; D014750:Vincristine / Q000008:administration & dosage; D014751:Vindesine / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D009607:Nitrosourea Compounds; D013629:Tamoxifen; D001761:Bleomycin; D013654:Taurine; D011344:Procarbazine; C052991:1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea; D014750:Vincristine; D008130:Lomustine; D003606:Dacarbazine; C017218:detorubicin; D003520:Cyclophosphamide; D013852:Thiotepa; D004999:Amifostine; D017239:Paclitaxel; D002945:Cisplatin; D014751:Vindesine; D002330:Carmustine; D003630:Daunorubicin