Kinetics of antibody response to hepatitis B virus determinants and to recombinant vaccines in Italy.
The kinetics of antibody response to the group determinant a and subdeterminants d and y of hepatitis B virus were studied after infection and following immunisation with two recombinant DNA yeast-derived hepatitis B vaccines. The initial antibody response was to the subdeterminant epitopes, whereas anti-a antibody, which provides protection against different subtypes of the virus, was not detected for some weeks or months. The delay in the development of anti-a antibody after active immunisation raises important issues of early protection against infection.
Zanetti
A R
AR
Institute of Virology, University of Milan, Italy.
Tanzi
E
E
Romano
L
L
Vigano
P
P
Cargnel
A
A
Hojvat
S
S
Zuckerman
A J
AJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000939:Epitopes; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007558:Italy; D007700:Kinetics; D008875:Middle Aged; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
D000939:Epitopes; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D014614:Vaccines, Synthetic; D014765:Viral Vaccines