The activity of locally applied cytotoxics to breast cancer cells in vitro.
The ability of commonly used operative lavage solutions to destroy breast cancer cells was investigated. The cytotoxicity of solutions of Savlon, noxythiolin, povidone iodine, hydrogen peroxide, bleomycin and water on two human breast cancer cell lines was measured in vitro. Viable cells were determined by ability to exclude trypan blue. Results have been analysed with standard non-parametric tests and demonstrate that all solutions tested significantly (P less than 0.01) reduced the number of viable cells recovered when compared with a control solution of phosphate buffered saline. Solutions of Savlon, 2.5% noxythiolin and povidone iodine were more effective than the other agents in reducing the number of recovered viable cells.
Park
K G
KG
Department of Clinical Surgery, University of Edinburgh.
Chetty
U
U
Scott
W
W
Miller
W
W
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000970:Antineoplastic Agents; D001761:Bleomycin / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002593:Cetrimonium Compounds / Q000494:pharmacology; D002710:Chlorhexidine / Q000494:pharmacology; D004338:Drug Combinations; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009677:Noxythiolin / Q000494:pharmacology; D011206:Povidone-Iodine / Q000494:pharmacology; D007507:Therapeutic Irrigation; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D000970:Antineoplastic Agents; D002593:Cetrimonium Compounds; D004338:Drug Combinations; D001761:Bleomycin; C012027:savlon; D009677:Noxythiolin; D011206:Povidone-Iodine; D006861:Hydrogen Peroxide; D002710:Chlorhexidine