title: [Contribution to the mechanism of the "factor VIII bypassing activity" (FEIBA)-reaction].
abstract: The principle of the FEIBactivity hadn't been defined in a sufficient manner up to now. Probably the factor VII or factor VIIa are playing a key role. According to own experiments the factor VII activity increases considerably in activated prothrombincomplex concentrates together with the quotient factor VIIa/VII. Factor VII should be administered in his activated form for bypassing. Fractions with limitation of the activation process to factor VII are of a low thrombogenicity. Among activated coagulation factors factor VIIa persists longest in the circulation and a bypass efficacy can be provoked only by this.
authors.affiliation: Bezirksinstitut für Blutspende- und Transfusionswesen Schwerin.
authors.forename: W
authors.initials: W
authors.lastname: Sander
authors.forename: K
authors.initials: K
authors.lastname: Wilms
mesh_terms: D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000502:physiology*; D005167:Factor VII / Q000502:physiology; D005169:Factor VIII / Q000502:physiology*; D015942:Factor VIIa / Q000502:physiology; D006801:Humans
chemical_list: D001779:Blood Coagulation Factors; D005167:Factor VII; D005169:Factor VIII; D015942:Factor VIIa
vernacular_title: Ein Beitrag zum Mechanismus der "Factor Eight Bypassing Activity" (FEIBA)-Wirkung.