Healthy individuals and patients with systemic lupus erythematosus have unique, person-specific spectra of antibodies detectable on immunoblots.
Through the technique of immunoblotting, the spectrum and organ specificity of antibodies in healthy individuals and patients with systemic lupus erythematosus were examined. It was demonstrated that healthy individuals and patients with autoimmune disease have antibodies, some tissue specific and some not tissue specific, which are present in a pattern that is unique to each individual.
Shapiro
P E
PE
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510.
McAllister
G
G
Lerner
E A
EA
Lerner
M R
MR
D000311:Adrenal Glands / Q000276:immunology; D000328:Adult; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D001921:Brain / Q000276:immunology; D005260:Female; D006367:HeLa Cells / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000276:immunology; D008168:Lung / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000276:immunology; D009928:Organ Specificity; D011233:Precipitin Tests; D012313:RNA / Q000032:analysis; D013950:Thymus Gland / Q000276:immunology
D001323:Autoantibodies; D012313:RNA