title: Histiocytic tumor of Meckel's cave. An intracranial equivalent of juvenile xanthogranuloma of the skin.
abstract: We present the case of a 7-year-old boy who had a solitary mass within Meckel's cave that recurred 6 weeks after the initial resection. The histological, immunohistochemical, electron-microscopical, and molecular genetical features established the lesion's histiocytic nature. Our findings showed that it was closely related to juvenile xanthogranuloma, a benign lesion that usually occurs in the skin but has not yet been histologically confirmed in the brain. The present tumor is different from other intracranial histiocytic and xanthogranulomatous lesions.
authors.affiliation: Department of Pathology, Würzburg University School of Medicine, F.R.G.
authors.forename: W
authors.initials: W
authors.lastname: Paulus
authors.forename: T
authors.initials: T
authors.lastname: Kirchner
authors.forename: M
authors.initials: M
authors.lastname: Michaela
authors.forename: J
authors.initials: J
authors.lastname: Kühl
authors.forename: M
authors.initials: M
authors.lastname: Warmuth-Metz
authors.forename: N
authors.initials: N
authors.lastname: Sörensen
authors.forename: H K
authors.initials: HK
authors.lastname: Müller-Hermelink
authors.forename: W
authors.initials: W
authors.lastname: Roggendorf
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000199:Actins / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D015139:Blotting, Southern; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002648:Child; D003390:Cranial Nerve Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D012871:Skin Diseases / Q000473:pathology*; D012668:Trigeminal Ganglion; D014972:Xanthogranuloma, Juvenile / Q000473:pathology*; D000514:alpha 1-Antichymotrypsin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000199:Actins; D015703:Antigens, CD; D004273:DNA, Neoplasm; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase