The acute phase protein response during parasitic infection.
There is a paucity of comprehensive studies of the APP response in parasitic infection. This should be remedied for two reasons. First, as there is a limited number of cytokines with hepatocyte-stimulating activities, and as each one elicits a unique spectrum of protein changes, examination of the APP response during infection could provide insight into the cytokines involved. Second, the presence of IL-1, IL-6 and TNF, the mediators of the APR, in tissues and circulation have important implications for subsequent immune responses.
Stadnyk
A
A
Dept of Pediatrics, IWK Children's Hospital, Dalhousie University, Halifax, Canada.
Gauldie
J
J
D000209:Acute-Phase Proteins / Q000096:biosynthesis* / Q000502:physiology; D000818:Animals; D002199:Capillary Permeability; D016207:Cytokines / Q000502:physiology; D005786:Gene Expression Regulation; D006790:Host-Parasite Interactions; D006801:Humans; D007249:Inflammation; D008099:Liver / Q000378:metabolism; D051379:Mice; D009349:Nematode Infections / Q000276:immunology / Q000503:physiopathology; D010272:Parasitic Diseases / Q000276:immunology / Q000503:physiopathology*; D011528:Protozoan Infections / Q000276:immunology / Q000503:physiopathology; D051381:Rats; D012555:Schistosomiasis mansoni / Q000276:immunology / Q000503:physiopathology
D000209:Acute-Phase Proteins; D016207:Cytokines