Liposome-mediated delivery stimulates a class I-restricted cytotoxic T cell response to soluble antigen.
Most soluble protein antigens are poor at priming class I-restricted cytotoxic cell activity. In this study we show that incorporation of one protein, ovalbumin, into liposomes converts this antigen into an effective stimulator of antigen-specific cytotoxicity. The mechanisms responsible for this phenomenon are discussed.
Lopes
L M
LM
Dept. Biology, University College of London.
Chain
B M
BM
D000818:Animals; D004337:Drug Carriers; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D008081:Liposomes / Q000008:administration & dosage; D051379:Mice; D010047:Ovalbumin / Q000008:administration & dosage* / Q000276:immunology; D010446:Peptide Fragments / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D004337:Drug Carriers; D015395:Histocompatibility Antigens Class I; D008081:Liposomes; D010446:Peptide Fragments; D010047:Ovalbumin