The influence of age on neurotransmitter turnover in the rat's superior colliculus.
Measurements of the turnover of dopamine, noradrenaline and serotonin and their metabolites have been performed in the superior colliculus of adult and aged rats. The turnover of dopamine, noradrenaline and their metabolites after pargyline treatment was significantly lower in aged rats than in adults. On the contrary, the synthesis rate of serotonin (measured by accumulation of 5-hydroxytryptophan after decarboxylase blockade) and the turnover rate of serotonin (after pargyline treatment) did not change during aging. These findings suggest that aging has a different effect on catecholamines and serotonin turnover in the superior colliculus of the aged rats.
Herrera
A J
AJ
Departamento de Bioquímica, Bromatología y Toxicología, Facultad de Farmacia Universidad de Sevilla, Spain.
Machado
A
A
Cano
J
J
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D006916:5-Hydroxytryptophan / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D006834:Hydrazines / Q000494:pharmacology; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D010293:Pargyline / Q000494:pharmacology; D011339:Probenecid / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013477:Superior Colliculi / Q000187:drug effects / Q000378:metabolism*
D006834:Hydrazines; D018377:Neurotransmitter Agents; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D010293:Pargyline; C004297:3-hydroxybenzylhydrazine; D006916:5-Hydroxytryptophan; D011339:Probenecid; D004298:Dopamine; D009638:Norepinephrine