Suppressive activity of interleukin 4 on the induction of antigen-specific cytotoxic T cells in humans.
The effect of interleukin 4 (IL 4) on the induction of cytotoxic T cells (CTL) was studied by using human peripheral blood lymphocytes in vitro. IL 4 suppressed the induction of CTL specific for allogeneic antigens in a concentration-dependent manner. However, IL 4 did not suppress proliferative responses induced with allogeneic antigens or mitogens. The suppressive effect of IL 4 on CTL induction was observed when IL 4 was added at the early period of the CTL induction culture, but not at the later period. Furthermore, IL 4 did not suppress the effector function of CTL to target cells. IL 4 suppressed the production of IL 1 by monocytes/macrophages and the production of IL 2 and the expression of IL 2 receptors on T cells. Moreover, IL 4 suppressed the induction of lymphokine-activated killer cells. These results suggest that IL 4 has a suppressive activity on the induction of killer cells in humans.
Yamashita
U
U
Department of Immunology and Parasitology, School of Medicine, Hiroshima University.
Tanaka
Y
Y
D000939:Epitopes; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000494:pharmacology*; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects*; D013997:Time Factors
D000939:Epitopes; D007375:Interleukin-1; D007376:Interleukin-2; D015847:Interleukin-4