Effects of cilazaprilat and enalaprilat on experimental dermatitis in guinea pigs.
Two non-sulfur containing ACE-inhibitors were tested concerning their local effect on experimental dermatitis in ovalbumin-sensitized guinea pigs. Enalaprilat but not cilazaprilat potentiated the ovalbumin-evoked inflammatory response. Furthermore, enalaprilat clearly enhanced the erythema evoked by substance P, whereas cilazaprilat did not. Concerning, the bradykinin-evoked erythema, enalaprilat significantly potentiated the response, whereas cilazaprilat only caused a slight increase. Our results suggest that different affinities for peptidases involved in degradation of inflammatory peptides can explain differences between the pro-inflammatory properties of enalaprilat and cilazaprilat.
Rosenqvist
U
U
Department of Pharmacology, Faculty of Health Sciences, Linköping University, Sweden.
Persson
K
K
Lindgren
B R
BR
Andersson
R G
RG
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000633:toxicity*; D000818:Animals; D001920:Bradykinin; D017315:Cilazapril / Q000031:analogs & derivatives*; D003872:Dermatitis / Q000209:etiology / Q000503:physiopathology; D004357:Drug Synergism; D015773:Enalaprilat / Q000633:toxicity*; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006168:Guinea Pigs; D007249:Inflammation / Q000139:chemically induced*; D010047:Ovalbumin; D011724:Pyridazines / Q000633:toxicity*; D013373:Substance P
D000806:Angiotensin-Converting Enzyme Inhibitors; D011724:Pyridazines; D017315:Cilazapril; D013373:Substance P; D010047:Ovalbumin; D015773:Enalaprilat; D001920:Bradykinin; C045980:cilazaprilat