RNA recognition: towards identifying determinants of specificity.
Members of a family of proteins containing a conserved approximately 80-amino acid RNA recognition motif (RRM) bind specifically to a wide variety of RNA molecules. Structural studies, in combination with sequence alignments, indicate the structural context of both conserved and non-conserved elements in the motif. These analyses suggest that all RRM proteins share a common fold and a similar protein-RNA interface, and that non-conserved residues contribute additional contacts for sequence-specific RNA recognition.
Kenan
D J
DJ
Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.
Query
C C
CC
Keene
J D
JD
D000595:Amino Acid Sequence; D002352:Carrier Proteins / Q000378:metabolism*; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins
D002352:Carrier Proteins; D016601:RNA-Binding Proteins; D012313:RNA