[Effect of immunomodulating drugs on the release and activities of lysosomal proteinases of the liver of rats with ethanol poisoning].
Increased activity of cathepsin A and D in the cytosol fraction and homogenate of the liver of rats intoxicated for 4 weeks with ethanol (0.6 g/100 g of the body weight) was found. The cytosol cathepsin A and D activities were unaffected under the influence of Levamisole and isoprinosine++. Encorton reduced the activity of both cathepsins in the cytosol fraction while it did not diminish their activities in the liver homogenates. Encorton, and to a markedly lesser degree, Levamisole and isoprinosine++ caused a regression of vacuolar degeneration and of necrotic lesions and an increase in the number of glycogen granules in the livers of ethanol-intoxicated rats.
Skrzydlewska
E
E
Zakładu Analizy Instrumentalnej, Akademii Medycznej, Białymstoku.
Chyczewski
L
L
Worowski
K
K
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000435:Alcoholic Intoxication / Q000201:enzymology*; D000818:Animals; D002268:Carboxypeptidases / Q000378:metabolism*; D043402:Cathepsin A; D002402:Cathepsin D / Q000378:metabolism*; D002403:Cathepsins / Q000378:metabolism*; D004195:Disease Models, Animal; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D007542:Inosine Pranobex / Q000008:administration & dosage / Q000494:pharmacology*; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000276:Adjuvants, Immunologic; D007978:Levamisole; D002268:Carboxypeptidases; D002403:Cathepsins; D043402:Cathepsin A; D002402:Cathepsin D; D011241:Prednisone; D007542:Inosine Pranobex
Wpływ leków immunomodulujacych na uwalnianie i aktywność proteinaz lizosomalnych watroby szczura w zatruciu etanolem.