Development of substance P, Leu-enkephalin and serotonin profiles in the lateral geniculate nuclear complex of albino rat.
Immunohistochemical studies for analysing the development of the profile of two peptides--substance P (SP) and Leu-enkephalin (Leu-ENK), and serotonin (SER)--have been conducted on the lateral geniculate nuclear (LGN) complex of albino rats at gestation day 18 and various postnatal age periods. SP immunoreactivity is found to increase from 1 day postnatal (DPN) up to 20 DPN and decrease thereafter, whereas the SER and Leu-ENK-immunoreactive fibres and terminals seen as occasional fibres at 1, 5, and 10 DPN are better visualized from 20 DPN and gradually increase up to 40 DPN. The possible role and significance of the changes seen in these putative neurotransmitters/neuromodulators with development are discussed.
Wadhwa
S
S
Department of Anatomy, All-India Institute of Medical Sciences, New Delhi.
Rath
S
S
Jotwani
G
G
Bijlani
V
V
D000375:Aging; D000818:Animals; D004743:Enkephalin, Leucine / Q000032:analysis*; D005333:Fetus; D005829:Geniculate Bodies / Q000033:anatomy & histology* / Q000196:embryology / Q000254:growth & development; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology*; D012701:Serotonin / Q000032:analysis*; D013373:Substance P / Q000032:analysis*
D012701:Serotonin; D013373:Substance P; D004743:Enkephalin, Leucine