title: [The toxic and immunomodulating properties of the somatic O-antigen polysaccharide of typhoid bacteria].
abstract: In experiments on random bred mice and mice of various strains it was shown that when administered parenterally typhoid bacteria O-somatic antigen polysaccharide possesses the immunomodulatory properties. It stimulates the non-specific resistance of the organism to bacterial infection, produces the polyclonal activation of beta-lymphocytes, possesses the adjuvant properties, activates cells of the mononuclear phagocytic system. At administration in therapeutic doses the drug is not toxic, possesses no carcinogenic, mutagenic and allergenic properties.
authors.forename: A P
authors.initials: AP
authors.lastname: Duplishcheva
authors.forename: N G
authors.initials: NG
authors.lastname: Sinilova
authors.forename: A M
authors.initials: AM
authors.lastname: Kharitonova
authors.forename: S I
authors.initials: SI
authors.lastname: Bykovskaia
authors.forename: L V
authors.initials: LV
authors.lastname: Grigor'eva
authors.forename: A E
authors.initials: AE
authors.lastname: Snegireva
authors.forename: G V
authors.initials: GV
authors.lastname: Shaposhnikova
authors.forename: I V
authors.initials: IV
authors.lastname: Andreeva
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Rusina
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000633:toxicity*; D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000633:toxicity*; D003043:Cocarcinogenesis; D006168:Guinea Pigs; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D007928:Lethal Dose 50; D007942:Leukemia, Experimental / Q000209:etiology; D051379:Mice; D009152:Mutagenicity Tests; D019081:O Antigens; D011135:Polysaccharides, Bacterial / Q000276:immunology / Q000633:toxicity*; D051381:Rats; D011925:Rauscher Virus; D012485:Salmonella typhi / Q000276:immunology*; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D019081:O Antigens; D011135:Polysaccharides, Bacterial; C029023:salmozan
vernacular_title: Toksicheskie i immunomoduliruiushchie svoĭstva polisakharida O-somaticheskogo antigena bakteriĭ briushnogo tifa.