title: Esculine, ranitidine and carbenoxolone: different modes of action on gastric mucosa.
abstract: 1. This study was designed to determine the antiulcerogenicity of esculine in various types of experimentally induced gastric ulcers in which the appearance of lesions is due to an ischemic process: cold-restraint stress and pylorus-ligated induced ulcers. 2. In the first experimental model, esculine (50 mg/kg) produced a significant diminution not only in the number of haemorrhagic stomachs (21.5% by 37.5% of the controls) but also in the ulcer index, U.I. (1.00 +/- 0.63, P less than 0.05). 3. When the mucosal damage was induced as a consequence of the pylorus-ligated gastric secretion, pretreatment of esculine (25 and 50 mg/kg) prevented the formation of gastric lesions (12.4 +/- 2.8, P less than 0.05 and 12.2 +/- 1.20, P less than 0.005), although it was less effective than ranitidine (2.8 +/- 1.8, P less than 0.025). However a significant reduction on the acidity with a dose of 25 mg/kg was observed (31.69 +/- 6.42, P less than 0.025). For the rest of the studied parameters: pepsin, histamine and Na and K electrolytes no differences with regard to the control groups were produced. 4. The effects of esculine on mucosal lesions produced by intragastric instillation of 1 ml of absolute ethanol, were also studied. In this model esculine did not show any protective effect and high U.I. values were obtained.
authors.affiliation: Laboratorio de Farmacognosia y Farmacodinamia, Facultad de Farmacia, Sevilla, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Marhuenda
authors.forename: C
authors.initials: C
authors.lastname: Alarcon de la Lastra
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002229:Carbenoxolone / Q000494:pharmacology*; D003080:Cold Temperature; D004929:Esculin / Q000494:pharmacology*; D000431:Ethanol; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009093:Mucus / Q000378:metabolism; D010434:Pepsin A / Q000378:metabolism; D011708:Pylorus / Q000502:physiology; D011899:Ranitidine / Q000494:pharmacology*; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control; D013315:Stress, Psychological / Q000150:complications
chemical_list: D000897:Anti-Ulcer Agents; D004929:Esculin; D000431:Ethanol; D011899:Ranitidine; D010434:Pepsin A; D002229:Carbenoxolone