Comparison of histamine release in cord blood and adult blood.
Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release. Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood. Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood.
Nielsen
B W
BW
Department of Pediatrics, University Hospital of Aarhus, Denmark.
Engberg
T M
TM
Bjerke
T
T
Schiøtz
P O
PO
D000375:Aging / Q000097:blood; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D001491:Basophils / Q000187:drug effects / Q000502:physiology*; D003208:Concanavalin A / Q000494:pharmacology; D005312:Fetal Blood / Q000378:metabolism*; D006632:Histamine / Q000097:blood; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000276:immunology; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology
D000888:Antibodies, Anti-Idiotypic; D003208:Concanavalin A; D007073:Immunoglobulin E; D009240:N-Formylmethionine Leucyl-Phenylalanine; D006632:Histamine