title: Biochemical and anatomical consequences of adult infraorbital nerve transection for serotonergic afferents within rat trigeminal subnuclei interpolaris and caudalis.
abstract: Immunocytochemistry and high-performance liquid chromatography with electrochemical detection (HPLC-ED) were used, more than 76 days after infraorbital nerve (ION) transection, to examine the distribution and density of serotonin-immunoreactive (5-HTIR) axons, as well as serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) content, within the infraorbital (IO) regions of subnuclei caudalis (SpVc) and interpolaris (SpVi). In SpVi, increases in 5-HT concentration and in density of 5-HTIR axonal varicosities were observed on the lesioned side. No changes were seen in SpVc.
authors.affiliation: Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061.
authors.forename: B G
authors.initials: BG
authors.lastname: Klein
authors.forename: W D
authors.initials: WD
authors.lastname: Blaker
mesh_terms: D000344:Afferent Pathways / Q000033:anatomy & histology / Q000502:physiology; D000818:Animals; D001369:Axons / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003714:Denervation; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009915:Orbit / Q000294:innervation*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis / Q000502:physiology*; D014275:Trigeminal Caudal Nucleus / Q000033:anatomy & histology* / Q000737:chemistry; D014279:Trigeminal Nucleus, Spinal / Q000033:anatomy & histology* / Q000737:chemistry
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid