[The dynamics of the healing of an infected fracture of mandibular bone exposed to andekalin and kontrikal].
Infected mandibular fracture was simulated in rats. 10 percent calcium chloride solution (control) or andecalin (10 U/Kg) and contrykal (2.5000 U/kg) were administered to fracture site by vacuum electrophoresis. Histologic examination has revealed that andecalin activated the exudative phase of inflammation and decelerated the proliferative processes. A contrary effect was induced by contrykal: rapidly decreasing exudation, activation of osteoclastic resorption of necrotic bone and of osteogenesis processes.
Sapargel'dyev
N B
NB
Babaev
R Iu
RIu
D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D008337:Mandibular Fractures / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D010184:Pancreatic Extracts / Q000627:therapeutic use*; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D011205:Povidone / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology
D004338:Drug Combinations; D010184:Pancreatic Extracts; C019256:pancreatic extract, povidone drug combination; D007611:Aprotinin; D010447:Peptide Hydrolases; D011205:Povidone
Dinamika zazhivleniia infitsirovannogo pereloma nizhnecheliustnoĭ kosti pri vozdeĭstvii andekalina i kontrikala.