Peptide-mediated allo-recognition of HLA-B27 by cytotoxic T lymphocytes.
The molecular basis of the recognition of class-I HLA antigens by allo-reactive cytotoxic T lymphocytes (CTL) remains obscure. This article reviews our work in which HLA-B27-specific allo-reactive CTL clones were obtained and their fine specificity was analyzed with a panel of structurally defined HLA-B27 natural variants and site-directed mutants expressed on human and mouse cells. The results have implications for the involvement of endogenous peptides in determining the clonal diversity of HLA-B27 allogeneic responses and the fine specificity of T-cell recognition when HLA-B27 is expressed on different cell types.
Rojo
S
S
Department of Immunology, Fundación Jiménez Díaz, Madrid, Spain.
López de Castro
J A
JA
D000818:Animals; D000915:Antibody Affinity; D000939:Epitopes / Q000276:immunology; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D051379:Mice; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000939:Epitopes; D015796:HLA-B27 Antigen; D007518:Isoantibodies