The effect of adrenal cortex hormones on heart and skeletal muscles amylases activity under conditions of alpha- and beta-adrenergic stimulation.
Influence of hydrocortisone (H), deoxycorticosterone (D), phenylephrine (F) and isoprenaline (I) on activity of alpha amylase (AA) = 4-glucohydrolase alpha-1, 4-glucan [3, 2, 1, 1] and glucoamylase (GA) = glucohydrolase alpha-1, 4-glucan [3, 2, 1, 3] was investigated in heart and skeletal muscle in rats, before and after adrenalectomy (AT). It was found that AT inhibits a rise in the activities of AA and GA caused by F in both investigated muscles, whereas the I given after AT loses its ability to inhibit GA activity in heart and skeletal muscle. Both H and D administered after AT recover the ability of F to an increase in the investigated enzyme activity whereas recovers I ability to inhibit amylase activity in the presence of H. It can be concluded that inhibition of amylase activity is muscles results from interaction between beta-adrenergic stimulation with glucocorticoids, while the increase in activities of these enzymes is a result of interaction between alpha-adrenergic stimulation with mineral tropic action of both D and H.
Dynarowicz
I
I
Department of Pharmacology, Veterinary Medicine Faculty, Academy of Agriculture and Technology, Olsztyn.
D000302:Adrenal Cortex / Q000187:drug effects / Q000502:physiology*; D000315:Adrenalectomy; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology; D005087:Glucan 1,4-alpha-Glucosidase / Q000378:metabolism; D006728:Hormones / Q000502:physiology*; D006854:Hydrocortisone / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009132:Muscles / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000516:alpha-Amylases / Q000378:metabolism
D006728:Hormones; D010656:Phenylephrine; D003900:Desoxycorticosterone; D000681:Amylases; D000516:alpha-Amylases; D005087:Glucan 1,4-alpha-Glucosidase; D007545:Isoproterenol; D006854:Hydrocortisone