Increased alpha-1-acid glycoprotein in depression lowers free fraction of imipramine.
Kehoe
W A
WA
Drug Dynamics Laboratory, School of Pharmacy, University of the Pacific, Stockton, California 95211.
Kwentus
J A
JA
Sheffel
W B
WB
Harralson
A F
AF
D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D003866:Depressive Disorder / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006760:Hospitalization; D006801:Humans; D007099:Imipramine / Q000097:blood* / Q000627:therapeutic use; D008297:Male; D011569:Psychiatric Status Rating Scales; D019966:Substance-Related Disorders / Q000097:blood; D000511:alpha-Macroglobulins / Q000032:analysis
D000209:Acute-Phase Proteins; D000511:alpha-Macroglobulins; D007099:Imipramine