Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily.
Plasma inter-alpha-trypsin inhibitor (I alpha TI) is a major representative of the superfamily of Kunitz-type protease inhibitors in mammals. Formerly, I alpha TI was considered to be a single polypeptide, but recent molecular genetic studies have demonstrated an unexpected multipolypeptide chain structure. The newly discovered genes and gene products form the basis of a new family of I alpha TI-related protease inhibitors.
Salier
J P
JP
INSERM Unit-78, BP 73, Boisguillaume, France.
D000510:Alpha-Globulins / Q000145:classification / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011480:Protease Inhibitors / Q000145:classification*
D000510:Alpha-Globulins; D011480:Protease Inhibitors; C011877:inter-alpha-inhibitor