The presence of NK3 tachykinin receptors on rat uterus.
The NK3 agonist, senktide, induced a potent contraction of rat uterus in the presence of tetrodotoxin, atropine and indomethacin, or the tachykinin receptor antagonists L-659877 and [D-Pro4,D-Trp7,9,10]substance P (4-11). Additional contractile and radioligand binding studies with receptor selective agonists and antagonists confirmed the presence of NK3 receptors and also revealed the presence of NK1 and NK2 receptors. The rat uterus is the second peripheral tissue in which a post-synaptic, non-neuronal NK3 receptor has been identified.
Barr
A J
AJ
University Department of Pharmacology, Oxford, U.K.
Watson
S P
SP
Bernal
A L
AL
Nimmo
A J
AJ
D000818:Animals; D001667:Binding, Competitive; D004600:Eledoisin / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D015288:Neurokinin A / Q000378:metabolism; D010446:Peptide Fragments / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D018039:Receptors, Tachykinin; D013373:Substance P / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D013388:Succinimides / Q000378:metabolism; D015320:Tachykinins / Q000378:metabolism; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000648:ultrastructure*
C043194:Bolton Hunter reagent-substance P conjugate; C043034:Bolton Hunter-eledoisin ligand; D010446:Peptide Fragments; D017981:Receptors, Neurotransmitter; D018039:Receptors, Tachykinin; D013388:Succinimides; D015320:Tachykinins; C054724:senktide; D013373:Substance P; D004600:Eledoisin; D015288:Neurokinin A