title: Effects of poliovirus replication on undifferentiated and differentiated monocytic U937 cells: comparative studies with human macrophages.
abstract: Poliovirus infection of either undifferentiated or differentiated U937 cells produced a decrease in the percentage of cells positive for the surface expression of the CD4, CD11c, CD14, or 8E11 antigens. The number of 4F2 surface molecules per cell increased in infected normal U937 cells, but was unaffected in differentiated cells. The level of O2- production in infected differentiated U937 cells was approximately 50% of that found when not infected. Finally, poliovirus RNA levels and infectious particle production were similar in either cell type.
authors.affiliation: Centro de Biología Molecular, Universidad Autónoma, CSIC, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: López-Guerrero
authors.forename: C
authors.initials: C
authors.lastname: Cabañas
authors.forename: C
authors.initials: C
authors.lastname: Bernabeu
authors.forename: M
authors.initials: M
authors.lastname: Fresno
authors.forename: M A
authors.initials: MA
authors.lastname: Alonso
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002454:Cell Differentiation; D002460:Cell Line; D006801:Humans; D007700:Kinetics; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000382:microbiology*; D010641:Phenotype; D017955:Poliovirus / Q000235:genetics / Q000502:physiology*; D012313:RNA / Q000096:biosynthesis; D013481:Superoxides / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014779:Virus Replication / Q000235:genetics
chemical_list: D015703:Antigens, CD; D000954:Antigens, Surface; D013481:Superoxides; D012313:RNA; D013755:Tetradecanoylphorbol Acetate