Non-Q-wave myocardial infarction associated with bleomycin and etoposide chemotherapy.
During chemotherapy with bleomycin and etoposide a 28-year-old male, suffering from germ-cell cancer, developed acute myocardial infarction. Under treatment with heparin and aspirin the patient revealed no Q-waves in ECG and recovery was without complications. Four weeks after onset of infarction, thallium-201 scintigraphy showed only a small irreversible, posteroseptal perfusion defect; coronary angiography was not performed. The chemotherapy regimen was continued and modified to etoposide as well as cisplatin and ifosfamide without recurrence of cardiac symptoms or ECG changes.
Schwarzer
S
S
Department of Medicine III, Landeskrankenhaus Graz, Austria.
Eber
B
B
Greinix
H
H
Lind
P
P
D000328:Adult; D000787:Angina Pectoris / Q000139:chemically induced / Q000175:diagnosis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D004452:Echocardiography; D004562:Electrocardiography / Q000187:drug effects*; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007527:Isoenzymes; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy*; D015899:Tomography, Emission-Computed, Single-Photon
D007527:Isoenzymes; D001761:Bleomycin; D005047:Etoposide; D003402:Creatine Kinase