Expression of nuclear retinoic acid receptors in rat adipose tissue.
Expression of nuclear retinoic acid receptors (RAR-alpha, beta and gamma) was examined by Northern blots in rat lung, liver, and adipose tissue. Three transcripts of approximate sizes 7.3, 3.7, and 2.8 Kb were detected in adipose tissue. In contrast to adipose tissue only 3.7 and 2.8 Kb mRNA species were detected in liver and lung. Two RAR-beta gene transcripts (3.3 and 3.0 Kb) were expressed in adipose tissue, liver, and lung. RAR-gamma mRNA (3.36 Kb) was detected in adipose tissue and lung. The distribution of three RARs in adipose tissue suggests the physiological role of retinoic acid in the regulation of specific genes via RARs in adipocytes.
Haq
R
R
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.
Chytil
F
F
D000273:Adipose Tissue / Q000502:physiology*; D015152:Blotting, Northern; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002467:Cell Nucleus / Q000502:physiology*; D003001:Cloning, Molecular; D008099:Liver / Q000502:physiology; D008168:Lung / Q000502:physiology; D009928:Organ Specificity; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D018168:Receptors, Retinoic Acid; D014212:Tretinoin / Q000378:metabolism
D002352:Carrier Proteins; D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D012313:RNA