title: [Levels of tumor necrosis factor and interleukin 1 in uremia and in hemodialysis].
abstract: The present study aimed to assess the serum levels of tumor necrosis factor (TNFalpha) and Interleukin-1 (IL-1) in uremic patients and those patients undergoing extracorporeal replacement therapy in relation to the duration of dialysis and the type of membrane. Serum cytokine values were assayed using an immunoradiometric technique (monoclonal antibodies) in 28 uremic patients and 7 healthy controls. TNFalpha levels were normal in control subjects but increased in uremic patients. Patients undergoing hemodialytic treatment showed increases which were statistically significant in comparison to basal levels, with a trend which was directly correlated to the duration of dialysis. No significant variations were induced by the different types of dialysis membranes used. In virtually all patients IL-1 values could not be assayed using this method.
authors.affiliation: Servizio di Nefrologia e Dialisi, Ospedale Sant'Andrea, Vercelli.
authors.forename: C
authors.initials: C
authors.lastname: Peona
authors.forename: A
authors.initials: A
authors.lastname: Fortina
authors.forename: P
authors.initials: P
authors.lastname: Colombo
authors.forename: O
authors.initials: O
authors.lastname: Filiberti
authors.forename: G
authors.initials: G
authors.lastname: Cagna
authors.forename: L
authors.initials: L
authors.lastname: Costantini
authors.forename: M
authors.initials: M
authors.lastname: Porcu
mesh_terms: D000180:Acrylic Resins; D000181:Acrylonitrile / Q000031:analogs & derivatives; D000328:Adult; D000368:Aged; D002482:Cellulose / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007372:Interferons / Q000097:blood; D007375:Interleukin-1 / Q000097:blood*; D007378:Interleukins / Q000097:blood; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis / Q000295:instrumentation; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014511:Uremia / Q000097:blood* / Q000628:therapy
chemical_list: D000180:Acrylic Resins; D007375:Interleukin-1; D007378:Interleukins; D008567:Membranes, Artificial; D014409:Tumor Necrosis Factor-alpha; C016892:AN-69; D002482:Cellulose; D007372:Interferons; C009865:cuprammonium cellulose; D000181:Acrylonitrile
vernacular_title: Livelli di tumor necrosis factor ed interleuchina-1 nell'uremia ed in emodialisi.