The renin-angiotensin system: a multidimensional source of control over alcohol consumption.
While the renin-angiotensin system has traditionally been considered part of a larger homeostatic process that regulates blood pressure and fluid/electrolyte balance, the data summarized in this review suggest a new and different kind of function- that of regulating the behavior of alcohol consumption. Using a wide variety of drug, genetic, dietary, surgical and neurosurgical manipulations all of which share the common property of altering activity in the renin-angiotensin system, the picture emerges of an inverse relationship between activity in the renin-angiotensin system and alcohol consumption. One possible mechanism of this effect may be a process of satiety where levels of the bioactive peptide angiotensin II exceeding a critical level, set behavioral processes into action that lead to a cessation in alcohol intake.
Grupp
L A
LA
Department of Pharmacology, University of Toronto, Ontario, Canada.
D000428:Alcohol Drinking / Q000503:physiopathology; D000437:Alcoholism / Q000503:physiopathology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D004032:Diet; D006636:Histamine Release; D006978:Hypertension, Renovascular / Q000503:physiopathology; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology*; D012527:Satiation
D000804:Angiotensin II