Genes for insulin-like growth factors I and II are expressed in senescent rat tissues.
Insulin-like growth factor IGF-I and IGF-II gene expression was measured for the first time in rat liver, brain and heart during the later stages of life, i.e., young adulthood (6 months) to senescence (25 months). IGF-I mRNA was detected in all three tissues at all ages. Its relative level decreased the most in the liver with advancing age. IGF-II mRNA was detected in the brain and heart but not the liver at all ages. The level of IGF-II mRNA decreased only slightly in the brain from young adulthood to senescence.
Park
G H
GH
Department of Physiology and Biophysics, University of Illinois, Urbana.
Buetow
D E
DE
D000375:Aging / Q000502:physiology*; D000818:Animals; D016375:Antisense Elements (Genetics); D001921:Brain / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006706:Homeostasis; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009693:Nucleic Acid Hybridization; D012313:RNA; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D016375:Antisense Elements (Genetics); D012333:RNA, Messenger; D012313:RNA; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II