title: Disposition of amino acid synaptic transmitters, acetylcholine and substance P in the LM-suprageniculate nuclear complex of the cat's thalamus.
abstract: Immunocytochemical analysis with antibodies raised against aspartate, glutamate, gamma-aminobutyrate (GABA), choline acetyltransferase (ChAT), and substance P (SP) have allowed the transmitter characterisation and distribution of cells of the lateralis medialis-nucleus suprageniculatus (LM-SG) complex to be made at the level of the light microscope. We have found that the intranuclear distributions of aspartate and glutamate differed substantially from that of GABA, as well as there being specific and, in some cases, major differences in the respective populations of cells labelled with all three amino-acid-sensitive antibodies. ChAT-labelled elements were disposed very similarly to acetylcholinesterase (AChE)-positive subregions of the nuclear complex, while SP labelling was comparatively weak, albeit present, throughout the region. These data provide an important first step towards the further understanding of the details of the neurochemical and functional identity of the LM-SG complex.
authors.affiliation: Department of Psychology, College of Arts and Sciences, University of North Carolina, Greensboro 27412-5001.
authors.forename: S
authors.initials: S
authors.lastname: Onodera
authors.forename: M
authors.initials: M
authors.lastname: Norita
authors.forename: K
authors.initials: K
authors.lastname: Takeda
authors.forename: T P
authors.initials: TP
authors.lastname: Hicks
mesh_terms: D000109:Acetylcholine / Q000032:analysis*; D000110:Acetylcholinesterase / Q000032:analysis; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis; D002415:Cats; D002795:Choline O-Acetyltransferase / Q000032:analysis; D005829:Geniculate Bodies; D005971:Glutamates / Q000032:analysis; D018698:Glutamic Acid; D007150:Immunohistochemistry; D018377:Neurotransmitter Agents / Q000032:analysis; D013373:Substance P / Q000032:analysis*; D013569:Synapses / Q000737:chemistry*; D013788:Thalamus / Q000737:chemistry* / Q000201:enzymology
chemical_list: D005971:Glutamates; D018377:Neurotransmitter Agents; D001224:Aspartic Acid; D013373:Substance P; D018698:Glutamic Acid; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D000109:Acetylcholine