title: Extracorporeal membrane oxygenation and early-onset group B streptococcal sepsis.
abstract: Recently, extracorporeal membrane oxygenation (ECMO) has been used as rescue therapy for newborns with overwhelming early-onset group B streptococcal sepsis. To determine which clinical factors best predict mortality and to evaluate the outcome of this therapy, a retrospective examination of the clinical course and outcome of ECMO-eligible newborns with early-onset group B streptococcal sepsis was undertaken. The study period was divided into two phases based on when ECMO was initially used at Kosair Children's Hospital as therapy for septic neonates. Phase 1 (pre-ECMO) was the period from January 1, 1982, through June 15, 1986, and phase 2 (ECMO) from June 16, 1986, through December 31, 1989. Newborns with gestational age greater than or equal to 34 weeks, birth weight greater than or equal to 2000 g, and evidence of early-onset group B streptococcal sepsis were eligible for study. Only newborns who received mechanical ventilation were evaluated. Sixteen patients from phase 1 met the above criteria. Of those, 10 exhibited no sign of hypotension and all survived. Of the 6 patients with hypotension, 3 died. Forty patients were identified from phase 2. Seven patients remained normotensive and all survived. Thirty-three patients were hypotensive, of which 15 received ECMO and 13 survived. Of the 18 who did not receive ECMO, 7 died. Regarding all hypotensive newborns, those who did not receive ECMO had a trend toward lower survival (P less than .06) and were more likely to die if they were of lower birth weight, manifested a persistent acidosis (pH less than or equal to 7.25), and had an absolute neutrophil count less than 500 cells/mm3.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, University of Louisville School of Medicine, KY.
authors.forename: J R
authors.initials: JR
authors.lastname: Hocker
authors.forename: P M
authors.initials: PM
authors.lastname: Simpson
authors.forename: G P
authors.initials: GP
authors.lastname: Rabalais
authors.forename: D L
authors.initials: DL
authors.lastname: Stewart
authors.forename: L N
authors.initials: LN
authors.lastname: Cook
mesh_terms: D000138:Acidosis / Q000209:etiology; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D007022:Hypotension / Q000209:etiology; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D009503:Neutropenia / Q000209:etiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013290:Streptococcal Infections / Q000150:complications / Q000628:therapy*; D013292:Streptococcus agalactiae; D013997:Time Factors