title: Distribution of substance P, GnRH, Met-enkephalin in the central nervous system of the pig.
abstract: The distribution of substance P (SP), gonadotropin releasing hormone (GnRH) and Met-enkephalin in the brain and spinal cord of the domestic pig is described for the first time. The levels of SP, GnRH and Met-enkephalin were measured by specific radioimmunoassays in various regions of the brain and spinal cord of the pig. Substance P and Met-enkephalin are widely distributed within the central nervous system of the pig. High levels of SP were found in the preoptic area (POA), suprachiasmatic area (SCA), medial basal hypothalamus (MBH) and brain stem while moderate amounts of SP were found in olfactory bulb (OB). High levels of Met-enkephalin were found in POA, SCA and MBH, and moderate levels of Met-enkephalin in OB and brain stem. Both SP and Met-enkephalin levels were higher in the dorsal spinal cord in comparison with the levels of these peptides in the ventral spinal cord. This finding is in agreement with the predominant role played by these neural systems in primary afferent mediation of nociceptive impulses. The POA and SCA contained only low levels of GnRH while the MBH contained high levels of GnRH. Finally, some differences in the quantitative distribution of these peptides in the pig and rat are discussed.
authors.affiliation: Department of Anatomy and Cellular Biology, Tufts University School of Veterinary Medicine, North Grafton, MA 01536.
authors.forename: M S
authors.initials: MS
authors.lastname: Kumar
authors.forename: T
authors.initials: T
authors.lastname: Becker
authors.forename: K
authors.initials: K
authors.lastname: Ebert
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D001923:Brain Chemistry; D004744:Enkephalin, Methionine / Q000032:analysis*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D009928:Organ Specificity; D013116:Spinal Cord / Q000033:anatomy & histology / Q000737:chemistry*; D013373:Substance P / Q000032:analysis*; D013552:Swine
chemical_list: D013373:Substance P; D007987:Gonadotropin-Releasing Hormone; D004744:Enkephalin, Methionine