title: Pharmacological actions of substance P in the rat vas deferens.
abstract: SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Universidad de Chile, Santiago.
authors.forename: H F
authors.initials: HF
authors.lastname: Miranda
authors.forename: W I
authors.initials: WI
authors.lastname: Silva
authors.forename: W W
authors.initials: WW
authors.lastname: Wolstenholme
authors.forename: N
authors.initials: N
authors.lastname: Cuevas
authors.forename: A
authors.initials: A
authors.lastname: Ucros
authors.forename: D
authors.initials: D
authors.lastname: Bustamante
authors.forename: E H
authors.initials: EH
authors.lastname: Fernández
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology*; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects*
chemical_list: D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D013373:Substance P