The sources of chemical substances in allergic nasal fluid.
The sources of different chemical substances in the NF of allergic patient, such as albumin, secretory IgA, histamine, leukotriene, kinin and substance P were investigated. To accomplish this, we challenged the inferior turbinate on one side, but separately collected NF from both sides in patients with nasal allergy to house-dust. Provocation was done with paper disc containing dried allergen extract. Collection was done by suction for the first five minutes immediately after the onset of a positive response to nasal provocation. The total amount of the chemical substances on each side was analyzed separately and compared. Significant differences were seen between both sides only for histamine and leukotriene. In consideration with the previous reports, it is suggested that in nasal allergen challenge the major sources are glandular secretion for secretory IgA, and albumin, and secretion for migrating cells for histamine and leukotriene. The major sources responsible for kinin and substance P, however, are not defined.
Ichikawa
K
K
Dept. of O.R.L., Nippon Medical School, Tokyo, Japan.
Okuda
M
M
Naka
F
F
Yago
H
H
D000293:Adolescent; D000418:Albumins / Q000032:analysis; D000818:Animals; D001826:Body Fluids / Q000737:chemistry*; D004391:Dust / Q000009:adverse effects; D005260:Female; D006632:Histamine / Q000032:analysis; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007705:Kinins / Q000032:analysis; D015289:Leukotrienes / Q000032:analysis; D008297:Male; D008925:Mites / Q000276:immunology; D009297:Nasal Mucosa / Q000378:metabolism*; D009299:Nasal Provocation Tests; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D013373:Substance P / Q000032:analysis
D000418:Albumins; D004391:Dust; D007071:Immunoglobulin A, Secretory; D007705:Kinins; D015289:Leukotrienes; D013373:Substance P; D006632:Histamine