title: Survival and fibre outgrowth of neuronal cells transplanted into brain areas associated with interstitial oedema.
abstract: The influence of interstitial oedema on the survival of fetal raphe cells transplanted into serotonin (5-HT)-denervated rats and the fibre outgrowth from these cells was investigated. Fetal raphe cells were transplanted into the corpus callosum in which long-lasting interstitial oedema had been induced by intracisternal kaolin injection. The 5-HT and 5HIAA levels in the corpus callosum were restored to their maximum within 5-6 weeks post-transplantation regardless of whether interstitial oedema was induced or not. Furthermore, it was appeared that the presence of interstitial oedema even facilitated fibre growth as demonstrated by the 5-HT immunohistochemistry and the restoration of the 5-HT and 5-HIAA levels in brain areas distant from the transplantation sites. These results imply favourable effects of interstitial oedema on the survival of transplanted raphe cells and their fibre outgrowth.
authors.affiliation: Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsubokawa
authors.forename: Y
authors.initials: Y
authors.lastname: Katayama
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Koshinaga
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D001929:Brain Edema / Q000503:physiopathology*; D002470:Cell Survival; D003714:Denervation; D005110:Extracellular Space / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D009474:Neurons / Q000502:physiology / Q000637:transplantation*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology; D014018:Tissue Distribution
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid