The central pressor actions of a novel tachykinin peptide, gamma-preprotachykinin-(72-92)-peptide amide.
Intracerebroventricular (i.c.v.) injections of a novel tachykinin peptide, gamma-preprotachykinin-(72-92)-peptide amide (neuropeptide gamma, NP gamma), caused dose-dependent increases in blood pressure. The NP gamma-induced pressor responses (1 microgram i.c.v.) were blocked by peripheral administration of pentolinium (10 mg/kg i.v.) and phentolamine (10 mg/kg i.v.), but were not inhibited by a vasopressin antagonist. These results suggest that central NP gamma increases the blood pressure via sympathetic nerve activity.
Hagio
T
T
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Takano
Y
Y
Nagashima
A
A
Nakayama
Y
Y
Tateishi
K
K
Kamiya
H
H
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D015288:Neurokinin A / Q000494:pharmacology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology; D015320:Tachykinins / Q000008:administration & dosage / Q000494:pharmacology*
D010446:Peptide Fragments; D015320:Tachykinins; C059905:tachykinin neuropeptide gamma; D013373:Substance P; D015288:Neurokinin A