T-cell depletion and haematological side effects of two cytotoxic monoclonal antibodies.
We investigated two cytotoxic monoclonal antibodies of BL-series (BL-IIIB4 and BL-IIG2) according to T-lymphocyte depletion from bone marrow. Both antibodies work together with human complement similar Campath-1, which was tested parallelly. The extent of T-cell depletion is about 95% for all three antibodies. On the other hand the haemopoietic side effects tested by CFU-GM recovery and LTBMC are for the BL-antibodies not as strong as for Campath-1, especially in view of LTBMC. T-cell regeneration could be shown in long term cultures. Our results indicate a possible suitability of the two investigated antibodies for T-cell depletion of bone marrow.
Leiblein
S
S
Department of Internal Medicine, Karl-Marx-University, Leipzig.
Schulze
E
E
Pönisch
W
W
Behn
I
I
Fiebig
H
H
Helbig
W
W
D000911:Antibodies, Monoclonal; D001854:Bone Marrow Cells; D002470:Cell Survival; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis; D006801:Humans; D008212:Lymphocyte Depletion; D012038:Regeneration; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000911:Antibodies, Monoclonal