Beneficial effects of a retinoic acid analog, CBS-211 A, on an experimental model of keratoconjunctivitis sicca.
We report the effects of CBS-211 A, a synthetic retinoic acid analog, on a previously described experimental model of keratoconjunctivitis sicca (KCS) in the rabbit. A 9-week topical treatment with 0.02% CBS-211 A in aqueous vehicle significantly increased the conjunctival goblet cell density (P less than 0.01, impression cytology counting), stopped the evolution of the corneo-conjunctival surface alteration (P less than 0.05, rose bengal test), and restored a basically normal mucosecretory product quality in goblet cells (lectin histochemistry) compared to vehicle treatment. The results assess the efficacy of this compound in reversing KCS pathology in a relevant model different from general vitamin A deficiency models, and strongly support the rationale for using such a well-tolerated retinoid in dry eye treatment.
Driot
J Y
JY
Chauvin Laboratory Research Centre, Montpellier, France.
Bonne
C
C
D000287:Administration, Topical; D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D002452:Cell Count; D003228:Conjunctiva / Q000378:metabolism / Q000648:ultrastructure; D004195:Disease Models, Animal; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011817:Rabbits
D001565:Benzoates; C062800:CBS 211 A