title: Memory is a property of an ion channels pool: ion channels formed by Staphylococcus aureus alpha-toxin.
abstract: The short-time depolarization effects on the integral conductance induced by S. aureus alpha-toxin (ST) in planar lipid bilayer membranes has been studied. Ion channels formed by ST were found to have several potential-induced nonconductance (closed) states. The transitions of ion channels between the states are only through one conductance state. The transition of ST-channels from closed to open state is induced by membrane depolarization. The amplitude current after a series of voltage pulses is a function of pulse number, and is effectively independent of the time interval between the neighbouring pulses. Therefore, a membrane which contains a pool of ion channels "remembers" its previous existence. A simple model can be used to explain this phenomenon.
authors.affiliation: Institute of Physiology, Academy of Sciences of the UzSSR, Taishkent.
authors.forename: O V
authors.initials: OV
authors.lastname: Krasilnikov
authors.forename: P G
authors.initials: PG
authors.lastname: Merzliak
authors.forename: R Z
authors.initials: RZ
authors.lastname: Sabirov
authors.forename: B A
authors.initials: BA
authors.lastname: Tashmuk-Hamedov
mesh_terms: D001427:Bacterial Toxins / Q000494:pharmacology*; D004553:Electric Conductivity; D004594:Electrophysiology; D006460:Hemolysin Proteins / Q000494:pharmacology*; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008051:Lipid Bilayers; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D013211:Staphylococcus aureus
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D007473:Ion Channels; D008051:Lipid Bilayers; C021091:staphylococcal alpha-toxin