[A study of crystallization on urolithiasis in vitro].
The formation, growth and aggregation of calcium oxalate crystals were evaluated with a Coulter counter. CG-120 and sodium pentosan polysulfate (SPP) has inhibitory activity on calcium oxalate crystal formation, growth and aggregation in the seeded crystal system and whole urine system. In continuous crystallizer system, they inhibit the nucleation rate. A new system of observing the crystal formation and growth of fragmented stones after extracorporeal shock wave lithotripsy has been developed. CG-120 has an inhibitory effect on their growth. The deposition of calcium oxalate crystals in the rat kidney was induced, and the, the volume and number of crystals were estimated using a Coulter counter. SPP has an inhibitory effect on calcium oxalate crystal growth in vivo.
Miyazawa
K
K
Department of Urology, Kanazawa Medical University.
Suzuki
K
K
Tsugawa
R
R
D000818:Animals; D002129:Calcium Oxalate / Q000378:metabolism / Q000652:urine; D002951:Citrates / Q000494:pharmacology; D019343:Citric Acid; D003460:Crystallization; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology; D051381:Rats; D014545:Urinary Calculi / Q000652:urine*
D002951:Citrates; D002129:Calcium Oxalate; D019343:Citric Acid; D010426:Pentosan Sulfuric Polyester