Impaired uptake of 5 hydroxytryptamine platelet in essential hypertension: clinical relevance.
Serotonin (5-hydroxytryptamine; 5HT) kinetics and platelet activation by 5HT were studied in patients with essential hypertension (n = 45), and in matched normotensive subjects (n = 45). Platelet response to 5HT and plasma beta-thromboglobulin increased with age in men, both normotensives and hypertensives. Beta-thromboglobulin and 5-hydroxyindoleacetic acid (5HIAA) excretion were higher in hypertensive men than in women. In women, no changes in platelet activity or 5HIAA excretion were found. 5HT plasma concentrations increased with blood pressure. Platelet 5HT uptake (Vmax and KM) were the lowest in hypertensive men greater than or equal to 60 years of age. This may indicate that 5HT uptake in vivo in normotensives is far below maximum (VNT much less than Vmax), whereas in hypertensive men it may be close to maximum (VHT approximately Vmax). This could reflect significantly higher 5HT plasma concentrations in vivo hypertensives than in normotensives. The reduced uptake (which was found only in hypertensive men) may indicate an insufficient compensation of the enhanced 5HT release from aggregating platelets in older men, in whom platelet activity is enhanced in vivo. It is concluded that the defect in platelet 5HT uptake in hypertensives--along with the enhanced platelet aggregation--may contribute to a critical increase in 5HT plasma concentrations locally. An increase in 5HT concentrations leads to biochemical changes (higher 5HIAA excretion) as well as to an enhanced stimulation by 5HT. This may be of clinical relevance especially in older men, in whom 5HT2-receptor mediated responses are enhanced.
Fetkovska
N
N
Clinic of Pharmacotherapy, Medical Bionics Research Institute, Bratislava, Czechoslovakia.
Pletscher
A
A
Ferracin
F
F
Amstein
R
R
Buhler
F R
FR
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology; D012701:Serotonin / Q000097:blood*; D012737:Sex Factors; D001620:beta-Thromboglobulin / Q000378:metabolism
D001620:beta-Thromboglobulin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid