title: Conization for CIN associated with human papillomavirus infection.
abstract: We report results of follow-up by PAP smears and colposcopy in 116 women treated since 1981 by conization for cervical intraepithelial neoplasia with human papillomavirus infection (HPV-CIN). The mean follow-up time was 31.9 (SD 19) months. Preoperative diagnosis was HPV-CIN II (with extension into the endocervix) in 11 cases and HPV-CIN III in 103 cases; two diagnostic conizations were performed. The histological examination of the cone biopsies showed complete excision of CIN in 109 cases (94%). Three patients underwent hysterectomy after conization; one had microinvasion in the cone biopsy, one had suspicion of microinvasion and one had non-radical conization. Three patients (2.6%) were lost to follow-up. After excluding these six patients the primary cure rate of HPV lesions (normal cytological and colposcopical finding after conization) was 82.7%. Four patients (4.6%) had residual CIN after conization. During the follow-up 15 patients had recurrence of HPV infection, only one had HPV-CIN I. HPV 16 was the most common HPV type (56/116, 48.2%) in the conization group and also in the recurrent cases (9/15, 60%). The results support the role of HPV 16 in cervical carcinogenesis.
authors.affiliation: Department of Obstetrics and Gynecology/3302, Kuopio University Central Hospital, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Yliskoski
authors.forename: S
authors.initials: S
authors.lastname: Saarikoski
authors.forename: K
authors.initials: K
authors.lastname: Syrjänen
mesh_terms: D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D003452:Cryosurgery; D015344:DNA Probes, HPV; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007372:Interferons / Q000008:administration & dosage; D053685:Laser Therapy; D009367:Neoplasm Staging; D065006:Papanicolaou Test; D027383:Papillomaviridae; D011446:Prospective Studies; D014412:Tumor Virus Infections / Q000473:pathology / Q000601:surgery*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D014626:Vaginal Smears
chemical_list: D015344:DNA Probes, HPV; D007372:Interferons