title: Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.
abstract: RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium-sized neurons of the striatum as demonstrated by in situ hybridization. We have now studied the relationship of this receptor with three major components of the rat caudate-putamen: enkephalin, substance P, and choline acetyltransferase. Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.
authors.affiliation: Erasme Hospital, Faculty of Medicine, Université Libre de Bruxelles, Belgium.
authors.forename: S N
authors.initials: SN
authors.lastname: Schiffmann
authors.forename: O
authors.initials: O
authors.lastname: Jacobs
authors.forename: J J
authors.initials: JJ
authors.lastname: Vanderhaeghen
mesh_terms: D000818:Animals; D002795:Choline O-Acetyltransferase / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure*; D004745:Enkephalins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015870:Gene Expression; D006651:Histocytochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011983:Receptors, Purinergic / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D013373:Substance P / Q000235:genetics / Q000378:metabolism* / Q000502:physiology
chemical_list: D004745:Enkephalins; D012333:RNA, Messenger; D011983:Receptors, Purinergic; D013373:Substance P; D002795:Choline O-Acetyltransferase