Genetic polymorphism of inter-alpha-trypsin-inhibitor (ITI): formal genetic and linkage analyses.
The polymorphism of inter-alpha-trypsin-inhibitor, ITI, was demonstrated by isoelectric focusing in agarose gels (pH 5-8) followed by protein blotting and immunoassay. Segregation in 239 families with 677 children is consistent with the formal hypothesis that there are two common codominant alleles, ITI*1, ITI*2, and one rare codominant allele, ITI*3, at an autosomal locus ITI. Allele frequencies were calculated as ITI*1 = 0.600, ITI*2 = 0.393, ITI*3 = 0.007. Linkage analysis with 36 markers is presented. Slightly positive lod scores were obtained for PGM3 (zeta = 1.35, theta = 0.10) and AK1 (zeta = 1.34, theta = 0.10).
Luckenbach
C
C
Institut für Anthropologie und Humangenetik, Tübingen, Federal Republic of Germany.
Kömpf
J
J
Ritter
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H
D000483:Alleles; D000510:Alpha-Globulins / Q000235:genetics*; D015153:Blotting, Western; D004587:Electrophoresis, Agar Gel; D008040:Genetic Linkage; D006801:Humans; D007124:Immunoenzyme Techniques; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic; D014361:Trypsin Inhibitors / Q000235:genetics*
D000510:Alpha-Globulins; D014361:Trypsin Inhibitors; C011877:inter-alpha-inhibitor