title: Selective effects of experimental glaucoma on axonal transport by retinal ganglion cells to the dorsal lateral geniculate nucleus.
abstract: Rapid-phase axonal transport to the dorsal lateral geniculate nucleus (dLGN) was determined autoradiographically in seven macaque monkey eyes with chronic intraocular pressure (IOP) elevation, in four eyes with an acute IOP elevation, and in three eyes with normal IOP. The monkeys with chronic IOP elevation showed a greater decrease in radioactive labeling of the magnocellular layers of the dLGN than the parvocellular layers by qualitative examination. Grain counts in selected specimens confirmed that transport to the magnocellular layers was less than to the parvocellular layers in monkeys with chronic IOP elevation. This selectivity was present in mildly damaged specimens and increased with greater ganglion cell loss. In monkeys with acute IOP elevation, qualitative evaluation suggested no consistent difference in transport among the dLGN layers; one animal in this group had less transport to the parvocellular than to the magnocellular layers by grain counts. Starting in early stages of the disease, chronic experimental glaucoma causes preferential damage to the ganglion cells that project to the magnocellular layers of the dLGN.
authors.affiliation: Glaucoma Service, Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: L
authors.initials: L
authors.lastname: Dandona
authors.forename: A
authors.initials: A
authors.lastname: Hendrickson
authors.forename: H A
authors.initials: HA
authors.lastname: Quigley
mesh_terms: D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport; D005829:Geniculate Bodies / Q000502:physiology*; D005901:Glaucoma / Q000473:pathology / Q000503:physiopathology*; D007429:Intraocular Pressure; D008252:Macaca fascicularis; D009900:Optic Nerve / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000502:physiology*