Effects of hydroxyethyl starch, nimodipine, and propylene glycol on cochlear blood flow.
A primary goal of pharmacologic treatment for otopathologies of vascular origin is to elevate cochlear blood flow (CoBF), thus facilitating the transport of oxygen and nutrients without compromising perfusion pressure in other tissues. In the present investigation, significant increases in CoBF were measured during intra-arterial infusion of the plasma expanding agent, hydroxyethyline starch (HES), and the vasodilator nimodipine, in anesthetized adult male guinea pigs. There were no changes in systemic blood pressure during the infusion of HES or nimodipine. Intra-arterial infusion of propylene glycol (PG), which is used as a nonaqueous solvent, produced inconsistent CoBF effects accompanied by initial decreases in systemic blood pressure with subsequent increases. It is concluded that nimodipine and HES are very promising agents for inducing increases in CoBF, whereas PG produced inconsistent effects on CoBF while elevating blood pressure, thus compromising its potential usefulness in the treatment of otopathologies.
Coleman
J K
JK
Department of Psychology, Washington State University, Pullman 99164-4820.
Dengerink
H A
HA
Wright
J W
JW
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D003051:Cochlea / Q000098:blood supply* / Q000187:drug effects; D006168:Guinea Pigs; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D009553:Nimodipine / Q000008:administration & dosage / Q000494:pharmacology*; D010953:Plasma Volume / Q000187:drug effects; D011409:Propylene Glycols / Q000494:pharmacology*; D011897:Random Allocation; D012039:Regional Blood Flow / Q000187:drug effects
D006895:Hydroxyethyl Starch Derivatives; D011409:Propylene Glycols; D009553:Nimodipine