title: DNA and RNA within the nucleus: how much sequence-specific spatial organization?
abstract: Spatial organization of various nuclear components is often proposed as a means by which nuclei more efficiently carry out their various tasks. Such functional compartmentalization may involve a sequence-specific packaging and placement of DNA and RNA. Here we review recent insights, allowed primarily by advances in fluorescent in situ hybridization methodology, into the organization of nucleic acids within individual nuclei.
authors.affiliation: University of Massachusetts Medical Center, Worcester 01655.
authors.forename: K C
authors.initials: KC
authors.lastname: Carter
authors.forename: J B
authors.initials: JB
authors.lastname: Lawrence
mesh_terms: D002453:Cell Cycle; D002843:Chromatin; D004247:DNA / Q000235:genetics*; D005455:Fluorescent Antibody Technique; D006801:Humans; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000235:genetics*
chemical_list: D002843:Chromatin; D012313:RNA; D004247:DNA