Effect of captopril on isoproterenol-induced myocardial ornithine decarboxylase activity.
Polyamines are thought to play an essential role in cellular hypertrophy and proliferation. Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in biosynthesis of polyamines. In this study, we evaluated the pathophysiological role of the renin-angiotensin system in isoproterenol-induced cardiac hypertrophy, using myocardial ODC activity as an indicator of cardiac hypertrophy. Isoproterenol caused an eight-fold increase of myocardial ODC activity in normotensive Wistar rats within 4 h after injection. Captopril suppressed the induction of ODC by isoproterenol to two-thirds of the control level. These results indicate that the renin-angiotensin system may participate in the induction of myocardial hypertrophy by isoproterenol.
Shimizu
M
M
Third Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Irimajiri
O
O
Nakano
T
T
Mizokami
T
T
Ogawa
K
K
Sanjo
J
J
Yamada
H
H
Sasaki
H
H
Isogai
Y
Y
D000818:Animals; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
D011073:Polyamines; D011943:Receptors, Adrenergic, beta; D012313:RNA; D004247:DNA; D002216:Captopril; D009955:Ornithine Decarboxylase; D007545:Isoproterenol