Chronic effects of cadmium on kidney, liver, testis, and fertility of male rats.
Male Wistar rats (n:20), at 5 wk of age, were given cadmium in drinking water (10 mg/L water) for 52 wk; 8 males and 20 female rats, as controls, were given tap water. At the end of 28 and 40 wk, some of the cadmium-treated males and control group male rats were sacrificed for the histopathological examination of testis, kidney, and liver. At the end of 56 wk, histopathological examinations were performed in the same way. Liver, kidney, and testis cadmium levels were also determined by atomic absorption spectrophotometry. All the cadmium-treated male rats showed pathological testicular alterations, and liver and kidney damage after chronic exposure. Cadmium levels were found to be highest in the kidney (1.009 +/- 0.034 microgram/g wet tissue in the infertile group). At the end of the 52-wk period, reproductive capacity of the cadmium-treated rats was investigated and was found to be lost in 39.89% of the animals.
Saygi
S
S
Department of Pharmacology and Toxicology, Gulhane Military Medical Academy and School, Etlik, Ankara, Turkey.
Deniz
G
G
Kutsal
O
O
Vural
N
N
D000818:Animals; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000473:pathology / Q000503:physiopathology*; D005298:Fertility / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D007672:Kidney Cortex / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D013090:Spermatocytes / Q000187:drug effects / Q000473:pathology; D013737:Testis / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D014018:Tissue Distribution
D002104:Cadmium