Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.
The mechanisms through which pristane or mineral oil can induce plasmacytomas in BALB/c or NZB mice are not fully understood, but involvement of interleukin 6 (IL-6), a growth factor for plasmacytomas and myelomas, has been strongly suggested. To clarify the role of IL-6 in plasmacytomagenesis, a human IL-6 cDNA was introduced into mouse germ lines under the transcriptional control of the murine major histocompatibility complex class I (H-2Ld) promoter. IL-6 transgenic mice of C57BL/6 origin developed a massive plasmacytosis but not plasmacytomas. However, introduction of BALB/c genetic background into IL-6 transgenic mice could generate monoclonal transplantable plasmacytomas with the chromosomal translocation t(12;15). These results provide firm evidence of the critical role of IL-6 in the plasmacytoma development.
Suematsu
S
S
Division of Immunology, Osaka University, Japan.
Matsusaka
T
T
Matsuda
T
T
Ohno
S
S
Miyazaki
J
J
Yamamura
K
K
Hirano
T
T
Kishimoto
T
T
D000818:Animals; D002871:Chromosome Banding; D002874:Chromosome Mapping; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D015850:Interleukin-6 / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic / Q000235:genetics*; D009368:Neoplasm Transplantation; D010375:Pedigree; D010954:Plasmacytoma / Q000235:genetics*; D014178:Translocation, Genetic
D015850:Interleukin-6