title: Effect of ketotifen on the methyltransferase activity of asthmatic patients.
abstract: The results of this study have revealed that asthmatic individuals have less methyltransferase activity, compared to healthy individuals. This is reflected in a less fluidity of the plasmatic membrane and thus, presents with less beta-receptors compared to healthy subjects. Ketotifen is capable of partially reversing this situation where it stimulates methyltransferase activity of asthmatic individuals approaching the enzyme activity to healthy individuals.
authors.affiliation: Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Pamplona, Spain.
authors.forename: J G
authors.initials: JG
authors.lastname: Castillo
authors.forename: P M
authors.initials: PM
authors.lastname: Gamboa
authors.forename: F
authors.initials: F
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Oehling
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000485:Allergens / Q000276:immunology; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000201:enzymology* / Q000473:pathology; D004789:Enzyme Activation / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007665:Ketotifen / Q000494:pharmacology*; D008560:Membrane Fluidity / Q000187:drug effects; D008780:Methyltransferases / Q000097:blood*; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D015290:Second Messenger Systems / Q000187:drug effects; D015854:Up-Regulation
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D011943:Receptors, Adrenergic, beta; D008780:Methyltransferases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D007665:Ketotifen