title: Effect of captopril on isoproterenol-induced myocardial ornithine decarboxylase activity.
abstract: Polyamines are thought to play an essential role in cellular hypertrophy and proliferation. Ornithine decarboxylase (ODC) catalyzes the first and probably the rate-limiting step in biosynthesis of polyamines. In this study, we evaluated the pathophysiological role of the renin-angiotensin system in isoproterenol-induced cardiac hypertrophy, using myocardial ODC activity as an indicator of cardiac hypertrophy. Isoproterenol caused an eight-fold increase of myocardial ODC activity in normotensive Wistar rats within 4 h after injection. Captopril suppressed the induction of ODC by isoproterenol to two-thirds of the control level. These results indicate that the renin-angiotensin system may participate in the induction of myocardial hypertrophy by isoproterenol.
authors.affiliation: Third Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shimizu
authors.forename: O
authors.initials: O
authors.lastname: Irimajiri
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Mizokami
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: J
authors.initials: J
authors.lastname: Sanjo
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Isogai
mesh_terms: D000818:Animals; D002216:Captopril / Q000008:administration & dosage / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D011943:Receptors, Adrenergic, beta / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D011073:Polyamines; D011943:Receptors, Adrenergic, beta; D012313:RNA; D004247:DNA; D002216:Captopril; D009955:Ornithine Decarboxylase; D007545:Isoproterenol