title: [Pharmacokinetic parameters as criteria for clinical use of hydroxyethyl starch preparations].
abstract: Pharmacokinetic Parameters as Criteria for Clinical Use of Hydroxyethyl Starch Preparations In a study with volunteers (n = 2 x 6) pharmacokinetic data of two only marginally differing starch preparations were investigated. We were able to demonstrate that there exist significant differences in raw materials used which determined the pharmacokinetic data in humans. Newly implemented analyzing methods (LALLS) were used. In addition to the degree of substitution, further differences concerning the position of hydroxyethylization at the anhydroglucose molecule could be documented. The C2/C6 positions of hydroxyethylization at the molecule seem to be most essential. To classify and to differentiate starch preparations we propose to include these data in general informations for clinicians because these differences might determine clinical usage and efficacy.
authors.affiliation: Abteilung für Anästhesiologie und operative Intensivmedizin, Justus-Liebig-Universität, Giessen.
authors.forename: B
authors.initials: B
authors.lastname: Weidler
authors.forename: B
authors.initials: B
authors.lastname: von Bormann
authors.forename: K
authors.initials: K
authors.lastname: Sommermeyer
authors.forename: E
authors.initials: E
authors.lastname: Lohmann
authors.forename: J
authors.initials: J
authors.lastname: Peil
authors.forename: G
authors.initials: G
authors.lastname: Hempelmann
mesh_terms: D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000493:pharmacokinetics*; D008297:Male; D008970:Molecular Weight; D014783:Viscosity
chemical_list: D006895:Hydroxyethyl Starch Derivatives
vernacular_title: Pharmakokinetische Merkmale als Kriterien für den klinischen Einsatz von Hydroxyethylstärke.