Effect of base precursors on water and electrolyte transport during oral hydration solution perfusion in secreting rat intestine.
In situ steady-state, single-pass small intestine perfusions in rats were carried out to compare the effect of the bicarbonate and citrate World Health Organization oral rehydration solutions and a base precursor-free solution on intestinal water and electrolyte transport after inducing intestinal secretion with purified heat-stable Escherichia coli enterotoxin. When toxin was not perfused, the rates of water, sodium, and bicarbonate absorption were significantly greater from the bicarbonate-containing solution than from the citrate or base precursor-free solutions. Chloride absorption was greater from the base precursor-free solution, but this might reflect the higher chloride concentration of the perfusate. When toxin was perfused, there was no significant difference among the solutions in the rates of water, potassium, or chloride absorption. Sodium absorption occurred at significantly greater rates from both the bicarbonate and the base precursor-free solutions than from the citrate solution. Base precursor-containing solutions may not provide any advantage over a base precursor-free solution in stimulating water and sodium absorption in 5'-cyclic guanosine monophosphate mediated acute diarrhea.
Rolston
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Wellcome Research Unit, Christian Medical College and Hospital, Vellore, India.
Mathan
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D000284:Administration, Oral; D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology; D001639:Bicarbonates / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002951:Citrates / Q000494:pharmacology*; D019343:Citric Acid; D004573:Electrolytes / Q000493:pharmacokinetics*; D004926:Escherichia coli; D005260:Female; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D015532:Rehydration Solutions / Q000494:pharmacology*; D012964:Sodium / Q000493:pharmacokinetics; D014867:Water / Q000378:metabolism*
D001427:Bacterial Toxins; D001639:Bicarbonates; D002951:Citrates; D004573:Electrolytes; D015532:Rehydration Solutions; D014867:Water; D019343:Citric Acid; D012964:Sodium