title: Staufen, a gene required to localize maternal RNAs in the Drosophila egg.
abstract: The posterior group gene staufen is required both for the localization of maternal determinants to the posterior pole of the Drosophila egg and for bicoid RNA to localize correctly to the anterior pole. We report the cloning and sequencing of staufen and show that staufen protein is one of the first molecules to localize to the posterior pole of the oocyte, perhaps in association with oskar RNA. Once localized, staufen is found in the polar granules and is required to hold other polar granule components at the posterior pole. By the time the egg is laid, staufen protein is also concentrated at the anterior pole, in the same region as bicoid RNA.
authors.affiliation: Max Planck Institut für Entwicklungsbiologie Abteilung III/Genetik, Tübingen, Federal Republic of Germany.
authors.forename: D
authors.initials: D
authors.lastname: St Johnston
authors.forename: D
authors.initials: D
authors.lastname: Beuchle
authors.forename: C
authors.initials: C
authors.lastname: Nüsslein-Volhard
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004330:Drosophila / Q000235:genetics* / Q000502:physiology; D029721:Drosophila Proteins; D005260:Female; D015870:Gene Expression; D005796:Genes; D007301:Insect Hormones / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D009866:Oogenesis; D010063:Ovum / Q000502:physiology*; D012313:RNA / Q000235:genetics*; D016601:RNA-Binding Proteins; D015183:Restriction Mapping
chemical_list: D029721:Drosophila Proteins; D007301:Insect Hormones; D016601:RNA-Binding Proteins; C069927:stau protein, Drosophila; D012313:RNA