Human T-cell leukemia virus type I associated lymphadenitis.
Histopathologic changes in lymph nodes were examined from ten patients with mild lymphadenopathy, a few atypical lymphocytes in their peripheral blood, skin lesions, and proviral DNA of human T-cell leukemia virus type I (HTLV-I) in their nodes. The proviral DNA of HTLV-I was detected by southern blot analysis, in situ hybridization, and/or polymerase chain reaction techniques. The lymph nodes showed preserved nodal architecture with diffuse infiltration of small to intermediate-sized lymphocytes in association with scattered transformed lymphocytes and a few immunoblast-like cells in the enlarged paracortex. The infiltrating lymphocytes were positive for CD4, but neither rearrangement nor deletion of T-cell receptors and immunoglobulin heavy chain genes was detected. Eight of ten patients received no therapy, and all patients were alive and healthy more than 5 months after the biopsies. The histologic findings resembled those of a viral infection and could be distinguished from HTLV-I associated lymphomas.
Ohshima
K
K
Department of Pathology, School of Medicine, Fukuoka University, Japan.
Kikuchi
M
M
Masuda
Y
Y
Sumiyoshi
Y
Y
Eguchi
F
F
Mohtai
H
H
Takeshita
M
M
Kimura
N
N
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D001483:Base Sequence; D015139:Blotting, Southern; D002675:Child, Preschool; D005260:Female; D015490:HTLV-I Infections / Q000276:immunology / Q000473:pathology*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology; D008199:Lymphadenitis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction
D015703:Antigens, CD