title: [Mechanisms of resistance to methotrexate].
authors.affiliation: Cattedra di Ematologia, Università degli Studi di Udine.
authors.forename: R
authors.initials: R
authors.lastname: Fanin
authors.forename: C
authors.initials: C
authors.lastname: Aschele
authors.forename: M
authors.initials: M
authors.lastname: Volkendandt
authors.forename: T M
authors.initials: TM
authors.lastname: Trippett
authors.forename: J T
authors.initials: JT
authors.lastname: Lin
authors.forename: J R
authors.initials: JR
authors.lastname: Bertino
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D006224:Cricetinae; D004247:DNA / Q000378:metabolism; D004351:Drug Resistance; D058973:Folate Receptors, GPI-Anchored; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008727:Methotrexate / Q000031:analogs & derivatives / Q000378:metabolism / Q000493:pharmacokinetics / Q000494:pharmacology*; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011956:Receptors, Cell Surface; D013379:Substrate Specificity; D013762:Tetrahydrofolate Dehydrogenase / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D009363:Neoplasm Proteins; D011956:Receptors, Cell Surface; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D004247:DNA; D013762:Tetrahydrofolate Dehydrogenase; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate
vernacular_title: Meccanismi di resistenza al metotrexate.