title: Kinetics of bioaccumulation and clearance of isomeric hexachlorocyclohexanes.
abstract: Bioaccumulation experiments were performed on the hexachlorocyclohexane isomers alpha-HCH, beta-HCH, gamma-HCH and delta-HCH, testing them simultaneously. Bioaccumulation factors (BCFs) were calculated from the uptake rate constant (k1) and the clearance rate constant (k2) as: BCF = k1/k2. The BCFs of alpha-HCH (1100 +/- 175) and gamma-HCH (920 +/- 131) were similar. The BCFs of beta-HCH (1520 +/- 276) and delta-HCH (1640 +/- 269), also similar, were significantly higher than those of the alpha- and gamma-isomers.
authors.affiliation: Fachbereich Chemie, Universität Oldenburg, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Butte
authors.forename: K
authors.initials: K
authors.lastname: Fox
authors.forename: G P
authors.initials: GP
authors.lastname: Zauke
mesh_terms: D000818:Animals; D001692:Biological Transport; D001556:Hexachlorocyclohexane / Q000031:analogs & derivatives* / Q000378:metabolism*; D007536:Isomerism; D007700:Kinetics; D008433:Mathematics; D013329:Structure-Activity Relationship; D015027:Zebrafish / Q000378:metabolism*
chemical_list: D001556:Hexachlorocyclohexane