FK506 lacks the ability to inhibit expression of interleukin-2 receptor beta-chain on human lymphocytes.
Proliferation of T-lymphocytes is induced by interleukin-2 binding to the interleukin-2 receptor. This receptor consists of an alpha and a beta chain. FK506 is a new immunosuppressant known to inhibit synthesis of interleukin 2 and expression of the membrane bound alpha chain. In this study we show that FK506 does not suppress the expression of the beta chain on human lymphocytes, in the concentration range 1 pM to 1 microM, as measured by flow cytometry.
Karlsson
H
H
Department of Medical Microbiology, University of Lund, Sweden.
Nässberger
L
L
D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis*; D016559:Tacrolimus / Q000494:pharmacology*
D015375:Receptors, Interleukin-2; D016559:Tacrolimus