title: [The behavior of substance P concentration in rat plasma in the acute single- and combined-actions of trichloroethylene and ethanol].
abstract: In experimental studies in male Wistar-rats exerted for determination of trichloroethylene, ethanol and combined action influences on the substance P plasma concentrations. These concentrations were determined by a radioimmunological method. The acute exposure of trichloroethylene and ethanol lead to a significant rise of substance P. We found high substance P concentration peaks, in principle, 4 h after acute exposure and the combined action shows the greatest effect.
authors.affiliation: Zentralinstitut für Arbeitsmedizin, Klinik und Poliklinik für Berufskrankheiten, Akademie für Arztliche Fortbildung.
authors.forename: R R
authors.initials: RR
authors.lastname: Fendius
authors.forename: T
authors.initials: T
authors.lastname: Gutewort
authors.forename: G
authors.initials: G
authors.lastname: Hinz
mesh_terms: D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000097:blood*; D014241:Trichloroethylene / Q000494:pharmacology*
chemical_list: D014241:Trichloroethylene; D013373:Substance P; D000431:Ethanol
vernacular_title: Das Verhalten der Substanz P-Konzentration im Rattenplasma unter akuter Einzel- und kombinierter Einwirkung von Trichlorethylen und Ethanol.