Demonstration of neurofibrillary tangles in parvalbumin-immunoreactive interneurones in the cerebral cortex of Alzheimer-type dementia brain.
The pathological changes occurring in a population of parvalbumin-like immunoreactive cerebral cortical interneurones in postmortem Alzheimer-type dementia brain tissue were determined by double staining cerebral cortical sections for parvalbumin, tau and/or calpain-like immunoreactivities. By counting the number of double immunostained cells it was determined that 4% parvalbumin and 25% of calpain-like immunoreactive cells showed evidence of tau-like immunoreactivity, indicative of neurofibrillary tangles. These results suggest that cerebral cortical parvalbumin-like immunoreactive neurones are relatively resistant to the pathological changes underlying the formation of neurofibrillary tangles associated with Alzheimer-type dementia.
Iwamoto
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Department of Neuroendocrinology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
Emson
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PC
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology*; D002154:Calpain / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007158:Immunologic Techniques; D007395:Interneurons / Q000378:metabolism* / Q000648:ultrastructure; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000648:ultrastructure*; D010320:Parvalbumins / Q000378:metabolism*; D013194:Staining and Labeling; D016875:tau Proteins / Q000378:metabolism
D010320:Parvalbumins; D016875:tau Proteins; D002154:Calpain