title: HIV, HBV and HCV seropositivity in hemophiliacs.
abstract: Eleven cases of severe type hemophiliacs who had received long-term factor VIII injections were tested for the serological markers of human immunodeficiency virus (HIV), hepatitis B virus and hepatitis C virus (HCV). The period of factor VIII concentrate injections ranged from 2 to 32 years. The seropositive rates of HIV and HCV were 9/11(82%) and 11/11(100%), respectively. The seropositive rate of hepatitis B surface antigen was only 1/11(9%), while the seropositive rates of antibody to hepatitis B core antigen and antibody to hepatitis B surface antigen were 9/11(82%) and 7/11(64%), respectively, Although the patients had no symptoms related to acquired immunodeficiency syndrome, they were noted to have inverted helper/suppressor T-lymphocyte ratio, suggesting that hemophiliacs with long-term factor VIII injections have a high incidence of HIV and HCV infection, with immunological aberration.
authors.affiliation: Department of Medicine, Veterans General Hospital-Taipei, Taiwan, Republic of China.
authors.forename: M P
authors.initials: MP
authors.lastname: Chow
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: J S
authors.initials: JS
authors.lastname: Lin
authors.forename: W K
authors.initials: WK
authors.lastname: Chau
authors.forename: C H
authors.initials: CH
authors.lastname: Ho
authors.forename: S Y
authors.initials: SY
authors.lastname: Chen
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Yung
mesh_terms: D000328:Adult; D005169:Factor VIII / Q000627:therapeutic use; D015658:HIV Infections / Q000209:etiology*; D006679:HIV Seropositivity; D006467:Hemophilia A / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000209:etiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006526:Hepatitis C / Q000209:etiology*; D018937:Hepatitis C Antibodies; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006508:Hepatitis Antibodies; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D005169:Factor VIII