[Cytokine regulation of hemopoietic stem cell proliferation].
The maintenance of mature blood cells requires the presence of hemopoietic stem cells, whose characteristics are their ability both to self-renew and to make differentiated progeny. We proposed a stochastic model for the mechanism of self-renewal and commitment of hemopoietic stem cells using in vitro clonal culture techniques. Recent progress in the molecular biology facilitated isolation and characterization of a number of cytokines that regulate the proliferation of hemopoietic stem cells. In this review, I summarize the current understanding of the mechanisms on interaction between several cytokines including IL-1, IL-3, IL-6, IL-11, G-CSF and stem cell factor (SCF).
Nakahata
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Dept. of Pediatrics, Shinshu University School of Medicine, Japan.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D016207:Cytokines / Q000502:physiology*; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology; D007377:Interleukin-3 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D051379:Mice; D019089:Stem Cell Factor
D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors; D007375:Interleukin-1; D007377:Interleukin-3; D015850:Interleukin-6; D019089:Stem Cell Factor; D016179:Granulocyte Colony-Stimulating Factor