Perfusion of rat colon with sennosides, rhein and rheinanthrone. Concentration-related histamine release.
Rat colon perfused intraluminally in vitro and in vivo released histamine into the perfusates. Histamine release was increased by rhein 0.1-10 micrograms/ml and much more by rheinanthrone 0.1-10 micrograms/ml but not by sennosides A or B 1-10 micrograms/ml. The effect of rhein and rheinanthrone was reduced by tritoqualine 20 mg/kg. This raises the possibility that laxation by senna and its derivatives involves histamine formation.
Autore
G
G
Department of Experimental Pharmacology, Via Domenico Montesano 49, Naples, Italy.
Caliendo
G
G
Pepe
A
A
Capasso
F
F
D000818:Animals; D000873:Anthracenes / Q000008:administration & dosage; D000880:Anthraquinones / Q000008:administration & dosage*; D002400:Cathartics / Q000008:administration & dosage; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012676:Senna Extract; D000081226:Sennosides; D000095322:Anthrones
D000873:Anthracenes; D000880:Anthraquinones; D002400:Cathartics; D012676:Senna Extract; D000081226:Sennosides; C055876:rhein-9-anthrone; D000095322:Anthrones; C020491:rhein