title: Cytokines: applications in domestic food animals.
abstract: Cytokines such as human, bovine, and porcine interferons and human and bovine interleukin-1 and interleukin-2 have been used in vivo in cattle and pigs. Colony-stimulating factors and tumor necrosis factor alpha have been evaluated in vitro in food animals. Studies to evaluate cytokines in domestic food animals have shown that specific and nonspecific immunomodulation is possible in immunosuppressed or pathogen-exposed animals. Cytokine prophylaxis or therapy in food animals may have the greatest potential for control of respiratory disease and mastitis.
authors.affiliation: Department of Anatomy and Physiology, Kansas State University, Manhattan 66506.
authors.forename: F
authors.initials: F
authors.lastname: Blecha
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D002417:Cattle; D002418:Cattle Diseases / Q000628:therapy*; D003115:Colony-Stimulating Factors / Q000627:therapeutic use; D016207:Cytokines / Q000627:therapeutic use*; D007372:Interferons / Q000627:therapeutic use; D007378:Interleukins / Q000627:therapeutic use; D013552:Swine; D013553:Swine Diseases / Q000628:therapy*
chemical_list: D003115:Colony-Stimulating Factors; D016207:Cytokines; D007378:Interleukins; D007372:Interferons