Ventricular fluid neuropeptides in Parkinson's disease. II. Levels of substance P-like immunoreactivity.
Substance P-like immunoreactivity (SPLI) was determined in cerebrovascular fluid of patients with extrapyramidal motor diseases. Patients with Parkinson's disease (PD) showed a SPLI concentration decreased by 30% compared with patients without extrapyramidal disease. No differences were apparent for patients with dystonia. Fluid obtained from the foramen Monro showed higher SPLI concentrations than fluid from a lateral ventricle, indicating that hypothalamic sources are important for ventricular substance P. Lateral ventricular SPLI was particularly low in parkinsonian patients which raises the possibility of a decreased SPergic activity in basal ganglia occurring in PD.
Cramer
H
H
Department of Neurology, University of Freiburg, FRG.
Jost
S
S
Reuner
C
C
Milios
E
E
Geiger
J
J
Mundinger
F
F
D000328:Adult; D000704:Analysis of Variance; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid*; D012016:Reference Values; D013373:Substance P / Q000134:cerebrospinal fluid* / Q000302:isolation & purification
D002556:Cerebrospinal Fluid Proteins; D013373:Substance P