Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat.
The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.
Puumala
M
M
Department of Neurosurgery, Mayo Graduate School of Medicine, Rochester, MN 55905.
Anderson
R E
RE
Meyer
F B
FB
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries / Q000473:pathology; D002552:Cerebral Ventricles / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage / Q000633:toxicity*; D007276:Injections, Intraventricular; D009389:Neovascularization, Pathologic / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values
D016222:Fibroblast Growth Factor 2