title: Neurogenic inflammation induced by capsaicin in patients with psoriasis.
abstract: Increasing doses of capsaicin were applied topically to the forearm skin of 30 patients with psoriasis, 16 patients with systemic scleroderma and 16 healthy volunteers. Only one-third of the patients with psoriasis responded with neurogenic inflammation to capsaicin doses of 0.125 and 0.25 microgram/cm2 in contrast to 81% of scleroderma patients and all the normal controls, who showed a positive cutaneous reaction. Higher doses of capsaicin (0.5-4 micrograms/cm2) were required to induce erythema and flare in patients with late-onset psoriasis (after 21 years of age) as well as in patients with more than 40% of skin surface involved with psoriatic lesion.
authors.affiliation: Department of Dermatology, Warsaw School of Medicine, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Glinski
authors.forename: M
authors.initials: M
authors.lastname: Glinska-Ferenz
authors.forename: M
authors.initials: M
authors.lastname: Pierozynska-Dubowska
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000367:Age Factors; D002211:Capsaicin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced; D005542:Forearm; D006801:Humans; D007249:Inflammation; D011565:Psoriasis / Q000188:drug therapy / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000294:innervation*; D013373:Substance P / Q000187:drug effects / Q000378:metabolism
chemical_list: D013373:Substance P; D002211:Capsaicin