Fish oil fatty acids and experimental arthritis.
Maintenance of mice on dietary regimens containing fish oil decreases severity of collagen-induced arthritis. Macrophages from fish oil fed animals had decreased omega-6 and significant amounts of omega-3 polyunsaturated fatty acids in membrane phospholipids and produced significantly less prostaglandins than macrophages from corn oil fed animals. Gender differences in both prostaglandin production and susceptibility to arthritis were noted.
Cathcart
E S
ES
Boston University School of Medicine, Massachusetts.
Gonnerman
W A
WA
D000209:Acute-Phase Proteins / Q000032:analysis; D000818:Animals; D001168:Arthritis / Q000097:blood / Q000139:chemically induced / Q000276:immunology*; D003094:Collagen; D016207:Cytokines / Q000494:pharmacology; D004347:Drug Interactions; D015777:Eicosanoids / Q000096:biosynthesis / Q000494:pharmacology; D005227:Fatty Acids / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology*; D006801:Humans; D011453:Prostaglandins / Q000096:biosynthesis; D012723:Sex
D000209:Acute-Phase Proteins; D016207:Cytokines; D015777:Eicosanoids; D005227:Fatty Acids; D005395:Fish Oils; D011453:Prostaglandins; D003094:Collagen