title: Immunoprofile of mucoepidermoid carcinomas of minor salivary glands.
abstract: Because the data on the antigenic phenotype of mucoepidermoid carcinoma (MEC) are incomplete and somewhat disparate, 45 MECs were evaluated immunohistochemically for low- and high-molecular-weight keratins, vimentin, glial fibrillary acidic protein, smooth muscle actin, and S-100 protein. Tumors stained uniformly for keratins and, on occasion, focally for vimentin. Tumors were nonreactive with antibodies to glial fibrillary acidic protein and, with few exceptions, to muscle-specific actins and S-100 protein. Clear cell and papillary histologic variants were seen as potential diagnostic pitfalls. If used with hematoxylin-and-eosin-stained sections, limited potential is seen for this antibody panel in surgical pathology. Myoepithelial cell-associated antigens are expressed to a very limited extent in MECs.
authors.affiliation: Department of Oral Medicine/Pathology/Surgery, School of Dentistry, University of Michigan, Ann Arbor.
authors.forename: J A
authors.initials: JA
authors.lastname: Regezi
authors.forename: R J
authors.initials: RJ
authors.lastname: Zarbo
authors.forename: J G
authors.initials: JG
authors.lastname: Batsakis
mesh_terms: D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000276:immunology*; D002675:Child, Preschool; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000276:immunology*; D012470:Salivary Glands, Minor / Q000276:immunology* / Q000503:physiopathology; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D014746:Vimentin; D007633:Keratins