title: [Histomorphology of BCG infections in patients with severe combined immunodeficiency].
abstract: Most inborn immunodeficiency syndromes clinically become overt by complicating infections, e.g. by BCG-infection after BCG-vaccination. The diagnostic approach often is hampered by an atypical histomorphological picture of the infection caused by the underlying immune defect. We examined biopsies of different organs in 18 infants with severe combined immunodeficiency syndrome and BCG-infection. A number of unusual histomorphological patterns of BCG-infection were found not yet published previously. There was a correlation between histomorphological features and immunological data or clinical course in most cases.
authors.affiliation: Abteilung für Kinderheilkunde II, Universität Ulm.
authors.forename: T
authors.initials: T
authors.lastname: Kohn
authors.forename: W
authors.initials: W
authors.lastname: Friedrich
authors.forename: A
authors.initials: A
authors.lastname: Nickl
authors.forename: B
authors.initials: B
authors.lastname: Heymer
mesh_terms: D000243:Adenosine Deaminase / Q000172:deficiency; D001500:BCG Vaccine; D001706:Biopsy; D006801:Humans; D007223:Infant; D008198:Lymph Nodes / Q000473:pathology*; D012189:Retrospective Studies; D016511:Severe Combined Immunodeficiency / Q000150:complications* / Q000473:pathology*; D014376:Tuberculosis / Q000209:etiology* / Q000473:pathology*
chemical_list: D001500:BCG Vaccine; D000243:Adenosine Deaminase
vernacular_title: Histomorphologie der BCG-Infektion bei angeborenem schwerem kombinierten Immundefekt.