title: The major serum protein of Drosophila larvae, larval serum protein 1, is dispensable.
abstract: Null alleles of all three genes (alpha, beta and gamma) coding for the major serum protein of Drosophila larvae, larval serum protein 1, have been characterized at the protein level and by analysis of their RNA and DNA. Each allele completely lacks one polypeptide chain. beta shows an unaltered gene but reduced levels of RNA, alpha shows restriction-fragment-length polymorphism and shows low levels of transcript, while gamma is a deletion. The three null alleles have been combined to give a strain without the gene for larval serum protein 1 which survives.
authors.affiliation: Biochemistry Department, University of Oxford, England.
authors.forename: D B
authors.initials: DB
authors.lastname: Roberts
authors.forename: T
authors.initials: T
authors.lastname: Jowett
authors.forename: J
authors.initials: J
authors.lastname: Hughes
authors.forename: D F
authors.initials: DF
authors.lastname: Smith
authors.forename: D M
authors.initials: DM
authors.lastname: Glover
mesh_terms: D000483:Alleles; D000818:Animals; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development; D014644:Genetic Variation; D007301:Insect Hormones / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D007814:Larva; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D015183:Restriction Mapping
chemical_list: D029721:Drosophila Proteins; D007301:Insect Hormones; C034648:larval serum protein, Drosophila; D012313:RNA; D004247:DNA