title: A new experimental trial using repeated heating every 24 hours for local hyperthermic therapy with bleomycin in vivo.
abstract: This report presents the effect of repeated heating every 24 hrs using bleomycin (BLM) which, although seemingly contrary to the usual agreement that hyperthermia should be carried out with a long interval due to thermotolerance, holds many possibilities. FM3A cells on the foot pad of C3H mouse were immersed in a heated water bath at 43 and 44 degrees C for 30 min. The effect of repeated heating was appreciated by an improved growth curve and 50 day survival compared to mice which received heating twice with a 96-hr interval. Repeated heating every 24 hrs 5 times with BLM suppressed tumor growth significantly as compared to heating twice with a 96-hr interval without BLM. The longest survival time was obtained by the repeated heating with BLM among all protocols. There is therefore a good possibility that more effective results could be obtained clinically by repeated heating over a short period.
authors.affiliation: Department of Surgery, Hiroshima University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: H
authors.initials: H
authors.lastname: Mukaida
authors.forename: T
authors.initials: T
authors.lastname: Iwata
authors.forename: T
authors.initials: T
authors.lastname: Toge
authors.forename: H J
authors.initials: HJ
authors.lastname: Hoon
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced / Q000379:methods*; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000401:mortality / Q000628:therapy*; D013997:Time Factors
chemical_list: D001761:Bleomycin