title: Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep.
abstract: The changes in propionate metabolism that accompany cobalt deficiency in sheep are described. Two groups of sheep, fed either a cobalt sufficient or deficient diet, were given an iv propionate load at intervals during a 14 w experiment. There was a tendency towards increased propionate half-life as the animals became cobalt deficient. However, significant changes in the area under the plasma methylmalonic acid-time curve occurred very early, indicating significant impairment of propionate metabolism. Despite this, the area under the plasma glucose-time curve was unaffected by cobalt deficiency, suggesting that the impairment of propionate metabolism, although significant, is not extensive.
authors.affiliation: Veterinary Research Laboratories, Belfast Northern Ireland, UK.
authors.forename: D G
authors.initials: DG
authors.lastname: Kennedy
authors.forename: F P
authors.initials: FP
authors.lastname: O'Harte
authors.forename: W J
authors.initials: WJ
authors.lastname: Blanchflower
authors.forename: D A
authors.initials: DA
authors.lastname: Rice
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003035:Cobalt / Q000172:deficiency*; D006207:Half-Life; D008764:Methylmalonic Acid / Q000378:metabolism; D011422:Propionates / Q000378:metabolism*; D012756:Sheep; D014805:Vitamin B 12 / Q000097:blood; D014806:Vitamin B 12 Deficiency / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D011422:Propionates; D003035:Cobalt; D008764:Methylmalonic Acid; D014805:Vitamin B 12