title: Detoxification of pertussis toxin by site-directed mutagenesis: a review of connaught strategy to develop a recombinant pertussis vaccine.
authors.affiliation: Connaught Centre for Biotechnology Research, Willowdale, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Loosmore
authors.forename: S
authors.initials: S
authors.lastname: Cockle
authors.forename: G
authors.initials: G
authors.lastname: Zealey
authors.forename: H
authors.initials: H
authors.lastname: Boux
authors.forename: K
authors.initials: K
authors.lastname: Phillips
authors.forename: R
authors.initials: R
authors.lastname: Fahim
authors.forename: M
authors.initials: M
authors.lastname: Klein
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D003001:Cloning, Molecular; D004252:DNA Mutational Analysis; D000939:Epitopes; D051379:Mice; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000235:genetics* / Q000276:immunology; D013329:Structure-Activity Relationship; D014614:Vaccines, Synthetic / Q000235:genetics* / Q000276:immunology; D010566:Virulence Factors, Bordetella / Q000235:genetics* / Q000276:immunology / Q000633:toxicity
chemical_list: D000942:Antigens, Bacterial; D000939:Epitopes; D010567:Pertussis Vaccine; D014614:Vaccines, Synthetic; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin