The development and repertoire of B-1 cells (CD5 B cells).
A small subset of mouse and human B cells produces much of the serum immunoglobulin, including many common autoreactive antibodies, and accounts for most cases of B-cell chronic lymphocytic leukemia. An exciting recent conference* focused on the development, repertoire and lineage classification of these cells. The meeting was convened for a discussion of 'CD5 B cells' but ended with a discussion of 'B-1 cells'.
Kantor
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Dept of Genetics, Stanford University Medical Center, CA 94305-5125.
D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D018956:CD5 Antigens; D006801:Humans; D016130:Immunophenotyping; D016753:Interleukin-10 / Q000276:immunology; D008024:Ligands
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D018956:CD5 Antigens; C064228:CD72 protein, human; D008024:Ligands; D016753:Interleukin-10