Persistent gestational trophoblastic disease following evacuation of a tetraploid partial hydatidiform mole.
A 31-year-old woman at 11 weeks gestation with ultrasonographic demonstration of partial mole had markedly elevated serum bHCG levels (458,000 mIU/ml). The patient underwent a vacuum curettage with pathological confirmation of the diagnosis, and cytogenetic analysis revealed a tetraploid karyotype (92,XXXX). The patient developed persistent gestational trophoblastic disease and was successfully treated with two courses of actinomycin D. Persistent trophoblastic disease after evacuation of a tetraploid partial mole was not reported previously.
Appelman
Z
Z
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Dgani
R
R
Zalel
Y
Y
Elchalal
U
U
Caspi
B
B
D000328:Adult; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006828:Hydatidiform Mole / Q000000981:diagnostic imaging / Q000235:genetics / Q000601:surgery*; D007621:Karyotyping; D011123:Polyploidy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000601:surgery*
D003609:Dactinomycin