title: [Problems of resistance of the causative agent of melioidosis to antibiotics].
abstract: It was shown that the pathogen causing melioidosis was highly resistant to antibiotics including beta-lactams. Antibiotic sensitive mutants of P. pseudomallei were isolated after mutagenesis induced by nitrosoguanidine. Permeability for 3H-tetracycline and tetracycline sensitivity of the mutant cells was respectively 3 and 20 times as high as those of the initial parent strain. Gas liquid chromatography revealed quantitative and qualitative changes in separate sugars of the lipopolysaccharide structure in antibiotic sensitive mutants as compared to the initial strain.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Antonov
authors.forename: L D
authors.initials: LD
authors.lastname: Popovtseva
authors.forename: R G
authors.initials: RG
authors.lastname: Iarulin
authors.forename: V I
authors.initials: VI
authors.lastname: Iliukhin
authors.forename: N A
authors.initials: NA
authors.lastname: Lozovaia
authors.forename: S M
authors.initials: SM
authors.lastname: Farber
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Knirel'
authors.forename: L D
authors.initials: LD
authors.lastname: Varbanets
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016957:Burkholderia pseudomallei / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000096:biosynthesis / Q000502:physiology; D008554:Melioidosis / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D016296:Mutagenesis / Q000187:drug effects; D009153:Mutagens; D009604:Nitrosoguanidines / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D009153:Mutagens; D009604:Nitrosoguanidines
vernacular_title: Problemy rezistentnosti vozbuditelia melioidoza k antibiotikam.