title: [Expression of latent membrane proteins (LMP) of Epstein-Barr virus in malignant lymphomas].
abstract: The presence of Epstein-Barr virus (EBV) DNA and antigens was assessed by polymerase chain reaction and immunohistology, respectively, in a total of 92 cases of Hodgkin's disease, angioimmunoblastic lymphadenopathy, CD30-positive anaplastic large cell (ALC) lymphomas, and AIDS-associated atypical lymphoproliferations (ALP). Proportions of the EBV DNA-positive lesions showed latent membrane protein (LMP) expression; some of the LMP-positive ALC lymphomas and ALP cases also displayed EBNA2 immunostaining. BZLF1-protein and gp250/350 immunoreactivity were absent in all instances indicating latent EBV infection. Since the LMP gene has transforming potential, our findings support the concept of a pathoetiological role for EBV in these lymphoproliferative lesions.
authors.affiliation: Institut für Pathologie, Klinikum Steglitz, Berlin.
authors.forename: H
authors.initials: H
authors.lastname: Herbst
authors.forename: F
authors.initials: F
authors.lastname: Dallenbach
authors.forename: G
authors.initials: G
authors.lastname: Niedobitek
authors.forename: I
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: M
authors.initials: M
authors.lastname: Hummel
authors.forename: T
authors.initials: T
authors.lastname: Finn
authors.forename: G
authors.initials: G
authors.lastname: Jautzke
authors.forename: N
authors.initials: N
authors.lastname: Müller-Lantzsch
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology; D000956:Antigens, Viral / Q000032:analysis*; D002051:Burkitt Lymphoma / Q000382:microbiology* / Q000473:pathology; D004279:DNA, Viral / Q000032:analysis* / Q000235:genetics; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000382:microbiology* / Q000473:pathology; D014764:Viral Proteins / Q000032:analysis*
chemical_list: D000956:Antigens, Viral; D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; D014764:Viral Proteins
vernacular_title: Expression des latenten Membranproteins (LMP) des Epstein-Barr-Virus in malignen Lymphomen.