[Evolution of regulatory proteins].
A concept of the evolution of signal molecules and their receptors is proposed. The formation of novel regulatory proteins by way of gene fusion and gene shuffling and the role of these processes in metabolic integration are considered. The different receptor variants may be due to alternative splicing which is regulated in a tissue-specific manner.
Medzhitov
R M
RM
D005075:Biological Evolution; D004247:DNA / Q000235:genetics; D021382:Protein Sorting Signals / Q000378:metabolism / Q000502:physiology; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D012313:RNA / Q000235:genetics; D012326:RNA Splicing
D021382:Protein Sorting Signals; D011506:Proteins; D012313:RNA; D004247:DNA
Evoliutsiia reguliatornykh belkov.