Detection of cancer metastases in regional lymph nodes: comparative histological and immunohistological investigations with the broad-range anticytokeratin monoclonal antibody A45-B/B3.
A total of 113 patients with carcinomas of breast, testis, stomach and colon were examined for lymph node metastases by means of an exact case-by-case comparison by conventional histology and by immunohistochemistry using the anticytokeratin monoclonal antibody A45-B/B3. Among 891 examined lymph nodes, 90% of metastases were recognized by both methods, about 2% by histology alone, and more than 10% by immunohistochemistry alone. The method can be applied for intraoperative frozen section diagnosis.
Stosiek
P
P
Department of Pathology, District Hospital, Görlitz, FRG.
Kasper
M
M
Karsten
U
U
Goertchen
R
R
D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D005629:Frozen Sections; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis*; D008198:Lymph Nodes / Q000737:chemistry* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D010232:Paraffin; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology; D013736:Testicular Neoplasms / Q000737:chemistry* / Q000473:pathology
D007633:Keratins; D010232:Paraffin