[The use of electron microscopy for diagnosing spongiform encephalopathies].
The authors suggest an unsophisticated approach to laboratory diagnosis of spongiform encephalopathies induced by unconventional prion viruses, consisting in electron microscopic detection of abnormal helical Scrapie-associated fibrils. These fibrils are detectable in human and animal brain tissue samples and in cell cultures.
Poleshchuk
N N
NN
Kapitulets
S P
SP
Il'kevich
Iu G
IuG
Kvacheva
Z B
ZB
D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D001927:Brain Diseases / Q000382:microbiology / Q000473:pathology*; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D011328:Prions; D014777:Virus Diseases / Q000382:microbiology / Q000473:pathology*
D011328:Prions
Ispol'zovanie élektronnoĭ mikroskopii dlia diagnostiki spongioformnykh éntsefalopatiĭ.