Neonatal exposure to substance P alters behavioral and substance P levels in the central nervous system of the adult rat.
Substance P (SP) administered subcutaneously to male and female rats during a neonatal period (days 1-7 after birth), produced long-term effects. Thermal/pain perception and elements of both male and female copulatory behavior were altered. A significant increase in the SP level in the dorsal part of the spinal cord was demonstrated by radioimmunoassay and by micro-fluorescence. The present study indicates that exposure to SP during the neonatal period, when the role of SP in transmission is likely to be established, has biochemical and functional consequences for SP systems in the adult.
Meyerson
B J
BJ
Department of Medical Pharmacology, University of Uppsala, Sweden.
Blomqvist
A
A
Ericson
A C
AC
Le Grevés
P
P
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D005123:Eye / Q000187:drug effects / Q000254:growth & development; D005260:Female; D005455:Fluorescent Antibody Technique; D008297:Male; D008832:Microchemistry; D010146:Pain / Q000503:physiopathology; D010446:Peptide Fragments / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013050:Spectrometry, Fluorescence; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D013373:Substance P / Q000378:metabolism / Q000494:pharmacology*; D014621:Vagina / Q000187:drug effects / Q000254:growth & development
D010446:Peptide Fragments; D013373:Substance P; C036877:substance P (1-7); D015740:Calcitonin Gene-Related Peptide