[Effect of hemodilution on systemic and capillary hematocrit].
In a cross-over study including 10 clinically healthy male volunteers, the hematocrit in the macro- and microcirculation was investigated prior to and 1 h, 3 h, 6 h and 24 h after iso- or (3 months later) hypervolemic hemodilution using 500 ml hydroxyethyl starch. The dilution effect observed after isovolemic hemodilution is more pronounced than after hypervolemic hemodilution. While isovolaemic hemodilution with 500 ml medium molecular weight hydroxyethyl starch leads to a reduction in the systemic hematocrit by 8.5% by volume, the capillary hematocrit at the time of the most marked dilution (1 h after hemodilution) decreases by only 1.3 hematocrit points in the cutaneous capillaries. After hypervolemic hemodilution, the systemic hematocrit decreases significantly by maximally 5.4% by volume, while the capillary hematocrit does not change significantly.
Jung
F
F
Abteilung für Klinische Haemostaseologie und Transfusionsmedizin, Universität des Saarlandes, Homburg/Saar.
Koscielny
J
J
Mrowietz
C
C
Wolf
S
S
Kiesewetter
H
H
Wenzel
E
E
D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D004903:Erythrocyte Aggregation / Q000187:drug effects; D004907:Erythrocyte Deformability / Q000187:drug effects; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects
D006895:Hydroxyethyl Starch Derivatives
Einfluss der Hämodilution auf den systemischen und den Kapillarhämatokrit.