[Serum macroamylase in a subject with non-Hodgkin's lymphoma].
Macroamylasemia (MA) is a rare condition characterized by an active macromolecular complex formed by normal amylase with abnormal proteins; to our knowledge, it has not been previously described in Mexico. The size of the macromolecular complex precludes its renal excretion; thus MA is characterized by high levels of amylase in serum with normal amylasuria. We report a 53-year-old male with abdominal pain and hyperamylasemia who was erroneously diagnosed as pancreatitis. Amylase in urine was normal and a protein electrophoresis demonstrated hyperglobulinemia. Several months after the initial work-up, the diagnosis of non-Hodgkin's lymphoma was established. Serum pancreatic amylase was again found elevated with normal urinary amylase. Precipitation of amylase with polyethylene-glycol was of 81% (normal: less than 70%). This established the diagnosis of MA associated to non-Hodgkin's lymphoma. After chemotherapy, the abnormal macroamylasemia and hyperglobulinemia disappeared.
Ramón Enríquez
J
J
Dept de Gastroenterología Instituto Nacional de al Nutrición, Salvador Zubirán, México, D.F.
Galván
E
E
Uscanga
L
L
Robles Díaz
G
G
D000437:Alcoholism / Q000150:complications; D000681:Amylases / Q000097:blood*; D011232:Chemical Precipitation; D003951:Diagnostic Errors; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010195:Pancreatitis / Q000175:diagnosis; D011092:Polyethylene Glycols
D009363:Neoplasm Proteins; D011092:Polyethylene Glycols; D000681:Amylases
Macroamilasemia en un sujeto con linfoma no-Hodgkin.