Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells.
The effect of acute ethanol (EtOH) exposure on 5-HT3 receptor-mediated ion current was examined in whole-cell patch-clamp recordings from NCB-20 neuroblastoma cells. The physiologic and pharmacologic properties of 5-HT-activated ion current in NCB-20 cells indicated that it was mediated by 5-HT3 receptors. EtOH potentiated 5-HT3 receptor-mediated current in a concentration-dependent manner at concentrations (25-100 mM) which are achieved during EtOH intoxication in vivo.
Lovinger
D M
DM
Unit of Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.
D000431:Ethanol / Q000494:pharmacology*; D007473:Ion Channels / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D007473:Ion Channels; D011985:Receptors, Serotonin; D000431:Ethanol