Endometrial carcinoma with trophoblastic differentiation. An aggressive form of uterine cancer.
Three cases of poorly differentiated endometrial adenocarcinoma showing trophoblast-like differentiation are reported. The multinucleated, syncytiotrophoblast-like cells were strongly positive for beta-human chorionic gonadotropin (beta-HCG) by immunohistochemical study. High levels of beta-HCG were also present in the patients' serum, but dropped significantly after treatment. The patients had an unusually rapid and progressive clinical course with widespread dissemination and death by tumor.
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C
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Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland 20892.
Merino
M J
MJ
Chambers
J T
JT
Nogales
F
F
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D006063:Chorionic Gonadotropin / Q000032:analysis; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010446:Peptide Fragments / Q000032:analysis; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology*
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments