Induced hypertension as an approach to treating acute cerebrovascular ischaemia: possibilities and limitations.
As, after an stroke, the autoregulation of the cerebral vessels in the ischaemic region is disturbed to a high degree, it is, on principle, possible to improve the blood flow particularly in the zone surrounding the infarct (penumbra) by raising the systemic blood pressure. During a basic treatment with low-molecular dextrans (infukoll M40), 37 patients with an acute ischaemic cerebral stroke multiply underwent elevations in blood pressure up to systolic values of about 210 to 220 mmHg. A comparison with a control group (n = 44) who were treated with low-molecular dextrans revealed no differences in lethality on the 21st day after the stroke. However, a very good acute effect in terms of a short-term improvement was remarkable a result that is noteworthy also in future.
Meier
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Department of Internal Medicine, Friedrich Schiller University, Jena-Lobeda, F.R.G.
Wessel
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Thiele
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Gottschild
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Brandstätt
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D000208:Acute Disease; D001794:Blood Pressure / Q000187:drug effects*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology; D003243:Consciousness / Q000187:drug effects; D003911:Dextrans / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008970:Molecular Weight; D010243:Paralysis / Q000503:physiopathology; D013997:Time Factors
D003911:Dextrans