Murine infantile polycystic kidney disease: a role for reduced renal epidermal growth factor.
Polycystic kidney disease (PKD) represents a form of renal epithelial hyperplasia. The C57BL/6J-cpk mouse, which has an infantile form of PKD, has a dramatically reduced expression of renal prepro-epidermal growth factor (EGF) mRNA and immunoreactive protein. Since EGF promoted maturation of epithelia in the neonate, the relative lack of renal EGF may contribute to the development of the collecting duct cysts by delaying epithelial maturation.
Gattone
V H
VH
Department of Anatomy, University of Kansas Medical Center, Kansas City.
Calvet
J P
JP
D000375:Aging / Q000235:genetics; D000818:Animals; D015152:Blotting, Northern; D004815:Epidermal Growth Factor / Q000235:genetics / Q000502:physiology*; D004848:Epithelium / Q000502:physiology; D005786:Gene Expression Regulation / Q000235:genetics; D007686:Kidney Tubules, Distal / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009693:Nucleic Acid Hybridization; D007690:Polycystic Kidney Diseases / Q000209:etiology* / Q000235:genetics; D012313:RNA / Q000235:genetics
D004815:Epidermal Growth Factor; D012313:RNA