[Fine structure of megakaryocyte precursor cells (promegakaryoblasts) derived from smears and sections of bone marrow tissue in patients with chronic myeloid leukemia and so-called primary osteomyelofibrosis with accompanying thrombocythemia].
An immunomorphometric study (antiglycoprotein III a - Y2/51) was performed on routinely processed trephine biopsies in 24 patients with chronic myeloid leukemia (CML) as well as so-called primary osteomyelofibrosis (OMF) to determine the frequency and fine structure of promegakaryoblasts (PMB). With respect to controls, there was a significant increase in megakaryocytes in both entities with an orderly expansion of the precursor subpopulation in CML, but a relative decrease in OMF. In comparison with smears of aspirates, sizes of PMB were reduced by about 25% (factor 1.4) in the corresponding bone marrow sections.
Thiele
J
J
Institut für Pathologie, Universität Köln.
Wagner
S
S
Sander
C
C
Dienemann
D
D
Weuste
R
R
Bertsch
H P
HP
Fischer
R
R
Stein
H
H
D001853:Bone Marrow / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000648:ultrastructure*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000473:pathology*; D008533:Megakaryocytes / Q000473:pathology / Q000648:ultrastructure*; D010019:Osteomyelitis / Q000097:blood / Q000473:pathology*; D013921:Thrombocytopenia / Q000150:complications / Q000473:pathology*
Die Feinstruktur der frühen megakaryozytären Vorläuferzellen (Promegakaryoblasten) im Ausstrich- und Schnittpräparat bei Patienten mit chronischer myeloischer Leukämie und sog. primärer Osteomyelofibrose mit begleitender Thrombozythämie.