title: [Hepatocellular carcinoma arising in the normal liver. A clinical study and long-term prognosis after surgical resection in 12 patients].
abstract: Hepatocellular carcinoma mainly affects patients with cirrhosis or with various degrees of fibrosis. From 1979 to 1990, among 87 patients who underwent hepatic resection for non fibrolamellar hepatocellular carcinoma, 12 (14%) had a non fibrolamellar hepatocellular carcinoma developed in a normal liver. There were 8 men and 4 women, aged 29 to 74 years. In 7 patients (58%) hepatocellular carcinoma was associated with clinical manifestations. Serum hepatitis B surface antigen were absent in all patients. Serum alphafetoprotein level was less than 100 ng/ml in 10 (83%), size of the tumor was greater than or equal to 5 cm in 10 (83%) and capsule was present in 10 (83%). Resections included removal of 2 segments or more in 11 (91%). One patient died postoperatively. Actuarial survival rate at 3 and 5 years were respectively 57% and 38%. Intra or extrahepatic recurrence was recognized in 8 (67%), 2 patients were alive respectively 28 and 16 months after treatment of their intrahepatic recurrence (resection in one and intraarterial embolisation in one). In conclusion, our results suggest that aggressive surgical efforts are justified in non fibrolamellar hepatocellular carcinoma arising in normal liver.
authors.affiliation: Service de Chirurgie digestive, Hôpital Beaujon, Clichy.
authors.forename: F
authors.initials: F
authors.lastname: Fekete
authors.forename: J
authors.initials: J
authors.lastname: Belghiti
authors.forename: J F
authors.initials: JF
authors.lastname: Flejou
authors.forename: Y
authors.initials: Y
authors.lastname: Panis
authors.forename: G
authors.initials: G
authors.lastname: Molas
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods* / Q000401:mortality; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006514:Hepatitis B Surface Antigens; D000509:alpha-Fetoproteins
vernacular_title: Carcinome hépatocellulaire sur foie sain. Etude clinique et pronostic à long terme après résection chirurgicale chez 12 malades.