[The Willebrand factor in the diagnosis of hemostatic disorders in patients with rheumatoid arthritis].
Studies of coagulation hemostasis in 108 patients with rheumatoid arthritis have revealed that high blood coagulation is characteristic of this disease, and a number of coagulation parameters (antithrombin III, fibrinogen, fibrinolytic activity, ethanol test) point to intravascular microthrombi formation (disseminated intravascular coagulation). Along with hemostasis investigations, Willebrand's factor levels were measured in the blood plasma of 44 patients. Enhancement of the inflammatory process activity was found to be associated with elevation of this factor level and augmentation of the blood coagulation activity. These results permit considering Willebrand's factor as one of the diagnostic criteria of thrombophilic conditions in patients with rheumatoid arthritis.
Demin
A S
AS
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014841:von Willebrand Factor / Q000032:analysis*
D014841:von Willebrand Factor
Faktor Villebranda v diagnostike narusheniĭ gemostaza u bol'nykh revmatoidnym artritom.