[Value of early amniocentesis for prenatal diagnosis in the first trimester of pregnancy].
For the prenatal diagnosis of the fetal status, amniocentesis was performed in 9-12-week pregnancy in 31 females at risk for birth of a baby with chromosomal abnormalities and congenital malformations of the central nervous system. There were no difficulties in carrying out the procedure. A balanced translocation-bearing female was found to have a fetal chromosomal abnormality. Her pregnancy was interrupted at the 11th week; the prenatal diagnosis was evidenced by cytogenetic examination of the abortion specimen. The amniotic fluid alpha-fetoprotein estimated by radioimmunoassay ranged from 15-18 to 550-620 ng/ml. The findings suggest that early amniocentesis may be useful in the prenatal diagnosis of the fetal status and further evidence should be accumulated.
Bakharev
V A
VA
Karetnikova
N A
NA
Polesterov
Iu A
IuA
Lisova
L P
LP
Iantovskiĭ
Iu R
IuR
D000649:Amniocentesis / Q000379:methods*; D000653:Amniotic Fluid / Q000737:chemistry / Q000166:cytology*; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins
Znachenie rannego amniotsenteza dlia prenatal'noĭ diagnostiki v I trimestre beremennosti.