R-cadherin: a novel Ca(2+)-dependent cell-cell adhesion molecule expressed in the retina.
cDNAs encoding a novel member of the cadherin cell adhesion receptor family were cloned. This cadherin is expressed in the retina of the chicken and is termed R-cadherin. It is similar to other cadherins in its primary structure, but most resembles N-cadherin, showing 74% amino acid identity. Cells expressing R-cadherin can adhere to those expressing N-cadherin when mixed, but they form homotypic clusters within their chimeric aggregates. In the development of the neural retina, R-cadherin begins to be expressed around embryonic day 8 in both neuronal and glial cells, and this expression continues up to the hatching stage. The pattern of the expression of R-cadherin was different from that of N-cadherin, suggesting distinctive roles in retinal morphogenesis.
Inuzuka
H
H
Department of Biophysics, Faculty of Science, Kyoto University, Japan.
Miyatani
S
S
Takeichi
M
M
D000595:Amino Acid Sequence; D000818:Animals; D015820:Cadherins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology*; D002642:Chick Embryo; D004247:DNA / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D008969:Molecular Sequence Data; D012160:Retina / Q000378:metabolism*; D013194:Staining and Labeling
D015820:Cadherins; D015815:Cell Adhesion Molecules; D004247:DNA