[Effect of cerulein on human salivary secretion].
To evaluate the effect of cerulein on salivary secretion in man, 25 healthy volunteers have been studied. In the morning, before breakfast, saline solution (125 ml/h) has been infused at a constant flow, for one hour. Saline solution has been followed, for other 60', by saline solution + Cerulein at doses of 0.05, 0.1, 0.2, 0.3, 0.5 microgram/Kg/h. These different doses have been administered in different days according to a randomized order. A wash out by saline solution, at same velocity as before, has been carried out after Cerulein . Samples of saliva were collected every 15'. On salivary specimens the amylase activity (U/l) has been dosed. Each dose of Cerulein induced a reduction of salivary flow. By blocking the administration of Cerulein the salivary secretion returned to basal value in about one hour. No inhibitory effect has been noted on amylase secretion using different doses of Cerulein .
Loguercio
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Cattedra di Fisiopatologia Digestiva, I Facoltà di Medicina e Chirurgia dell'Università di Napoli.
Costato
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Del Vecchio Blanco
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D000328:Adult; D000681:Amylases / Q000378:metabolism; D002108:Ceruletide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012472:Salivation / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects
D002108:Ceruletide; D000681:Amylases
Effetto della ceruleina sulla secrezione salivare dell'uomo.