Inhibitory binding of adenosine diphosphoribosyl transferase to the DNA primer site of reverse transcriptase templates.
Purified adenosine diphosphoribose transferase protein binds to RNA-DNA hybrid templates of reverse transcriptase at the DNA primer site and inhibits RT activity of HIV and MMu RTs. This action is prevented by auto-poly-ADP-ribosylation of the transferase but is reinduced by inhibitory ligands of the enzyme.
Buki
K G
KG
Laboratory for Environmental Toxicology and Chemistry, San Francisco State University, Tiburon, CA 94920.
Bauer
P I
PI
Kun
E
E
D006678:HIV / Q000201:enzymology*; D007700:Kinetics; D008024:Ligands; D008979:Moloney murine leukemia virus / Q000201:enzymology*; D009693:Nucleic Acid Hybridization; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011485:Protein Binding; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D018894:Reverse Transcriptase Inhibitors; D013698:Templates, Genetic
D008024:Ligands; D018894:Reverse Transcriptase Inhibitors; D011065:Poly(ADP-ribose) Polymerases; D012194:RNA-Directed DNA Polymerase