Influence of quinolinic acid, an endogenous neurotoxin, on a passive avoidance conditioned reflex in rats.
Quinolinic acid, an endogenous neurotoxin, was introduced into the cerebral ventricles of a rat in doses of 0.5 microgram and 30 micrograms. The influence of the substance on the reproduction of a passive avoidance conditioned reflex (CR) was evaluated. It was found that a small dose of the preparation decreases extinction, while a large dose disrupts the reproduction of a passive avoidance CR. The disruption of the reproduction of the skill was also observed after bilateral electrolytic destruction of the dorsal hippocampus. Quinolinic degeneration of this structure exerted a substantial influence on the reproduction of a passive avoidance CR.
Kozlovskii
V L
VL
V. M. Bekhterev Psychoneurological Institute, Leningrad.
Kenunen
O G
OG
Prakh'e
I V
IV
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000033:anatomy & histology; D003216:Conditioning, Operant / Q000187:drug effects*; D006624:Hippocampus / Q000502:physiology; D008297:Male; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000494:pharmacology*; D051381:Rats; D013194:Staining and Labeling
D011805:Quinolinic Acids; D017378:Quinolinic Acid