title: Alpha-fetoprotein.
abstract: The past year has seen major challenges to existing maternal serum alpha-fetoprotein testing protocols for both neural tube defects and chromosomal anomalies. These challenges are reviewed along with the physiology of alpha-fetoprotein; the use of amniocentesis, ultrasonography, and additional serum markers in women with elevated alpha-fetoprotein levels; and epidemiologic implications of maternal serum alpha-fetoprotein screening.
authors.affiliation: Hutzel Hospital-Wayne State University, Detroit, Michigan.
authors.forename: A
authors.initials: A
authors.lastname: Drugan
authors.forename: E
authors.initials: E
authors.lastname: Dvorin
authors.forename: J E
authors.initials: JE
authors.lastname: Obrien
authors.forename: M P
authors.initials: MP
authors.lastname: Johnson
authors.forename: M I
authors.initials: MI
authors.lastname: Evans
mesh_terms: D000013:Congenital Abnormalities / Q000175:diagnosis*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D009436:Neural Tube Defects / Q000175:diagnosis; D011247:Pregnancy; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins