Ionic channels: modulation by G proteins and by phosphorylation.
The gating of ion channels may be modulated by G proteins or by phosphorylation. Direct coupling between G proteins and ion channels has been shown in excised patches of membrane. Steps must now be taken to study the protein domains of G proteins and ion channels involved in the mutual interaction. The concept of channel modulation by protein kinases has recently been extended to include additional types of ion channel.
Reuter
H
H
Department of Pharmacology, University of Berne, Switzerland.
Sigel
E
E
D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D010766:Phosphorylation
D007473:Ion Channels; D019204:GTP-Binding Proteins