title: A CTL epitope on the circumsporozoite protein of P. yoelii.
abstract: Humans are infected with malaria by the bite of anophelene mosquitos carrying plasmodia sporozoites. These sporozoites pass quickly from the blood into hepatocytes, where they develop into mature liver-stage parasites over several days. The clinical stage of the illness begins only when the liver-stage parasites rupture into the bloodstream and erythrocytes are invaded. The pre-erythrocytic stages of malaria are inviting targets for vaccine development, because an effective immune response to these early stages would prevent symptomatic infections.
authors.affiliation: Infectious Disease Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.
authors.forename: W R
authors.initials: WR
authors.lastname: Weiss
authors.forename: R A
authors.initials: RA
authors.lastname: Houghten
authors.forename: M F
authors.initials: MF
authors.lastname: Good
authors.forename: J A
authors.initials: JA
authors.lastname: Berzofsky
authors.forename: L H
authors.initials: LH
authors.lastname: Miller
authors.forename: S L
authors.initials: SL
authors.lastname: Hoffman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000235:genetics / Q000276:immunology*; D002478:Cells, Cultured; D000939:Epitopes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010967:Plasmodium yoelii / Q000235:genetics / Q000276:immunology*; D015800:Protozoan Proteins; D013154:Spleen / Q000166:cytology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D000939:Epitopes; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan