Phosphate as a factor in sodium sensitivity in normal and high renin hypertension.
Disturbed phosphate (PO4) metabolism has been documented in spontaneously hypertensive rats but poorly studied in humans. Twenty-seven drug-free hypertensive subjects were studied on both a 10- and 100-mmol sodium diet. The response of mean arterial pressure to sodium repletion was directly correlated to the response of plasma renin activity (r = 0.540, p = 0.004) and inversely related to the percent response of serum PO4 concentrations. In the sodium-replete state serum PO4 concentration correlated inversely with plasma vitamin D concentration (r = 0.419, p = 0.026), consistent with PO4 acting as a determinate of vitamin D production. The response of serum calcium and plasma vitamin D concentrations to sodium repletion were correlated (r = 0.392, p = 0.043), consistent with serum calcium levels being a dependent variable, but the responses of serum PO4 and vitamin D concentrations were not. This study suggests that PO4 metabolism may be a determinate of blood pressure response to sodium repletion.
Hawkins
R G
RG
Department of Medicine, Faculty of Medicine, University of Calgary, Alberta, Canada.
Burgess
E D
ED
Watanabe
M
M
D000328:Adult; D001794:Blood Pressure; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D010710:Phosphates / Q000097:blood*; D012016:Reference Values; D012083:Renin / Q000097:blood; D012982:Sodium, Dietary; D014807:Vitamin D / Q000097:blood
D010710:Phosphates; D012982:Sodium, Dietary; D014807:Vitamin D; D012083:Renin; D002118:Calcium