Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump.
The stability of cisplatin (DDP) solutions (1 and 1.6 mg/ml in saline-mannitol) in plastic infusion bags was studied for up to 14 days at 25 degrees C, 37 degrees C and 60 degrees C. Small changes in the solution were observed, but no evidence of any decomposition product was seen. Some precipitation of DDP was seen in the 1.6-mg/ml solution at the lower temperatures. Fluid loss from the bags was significant at the higher temperatures.
Hrubisko
M
M
Cancer Research Institute, Slovak Academy of Sciences, Bratislava.
Mc Gown
A T
AT
Prendiville
J A
JA
Radford
J A
JA
Thatcher
N
N
Fox
B W
BW
D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000008:administration & dosage* / Q000737:chemistry; D004355:Drug Stability; D007260:Infusion Pumps; D012996:Solutions; D013696:Temperature; D013997:Time Factors
D012996:Solutions; D002945:Cisplatin