title: Specific uptake of asialofetuin-tacked liposomes encapsulating interferon-gamma by human hepatoma cells and its inhibitory effect on hepatitis B virus replication.
abstract: Asialofetuin-tacked liposomes (AF-liposomes) encapsulating interferon (IFN)-gamma were bound and internalized into a human hepatoma cell line, HepG2 cells, selectively through asialoglycoprotein receptor, but not non-tacked liposomes (N-liposomes). AF-liposomal IFN-gamma was more effective for inhibition of viral DNA replication in hepatitis B virus (HBV)-producing clone from HepG2 cells transfected with HBV-DNA than N-liposomal IFN-gamma. AF-liposomes may increase the therapeutic potential of IFN-gamma through asialoglycoprotein receptor in treating HBV-infected hepatocytes.
authors.affiliation: Tokyo College of Pharmacy, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: Y
authors.initials: Y
authors.lastname: Aramaki
authors.forename: S
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Koike
mesh_terms: D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins; D001692:Biological Transport; D006528:Carcinoma, Hepatocellular; D002460:Cell Line; D004337:Drug Carriers; D060748:Fetuins; D006515:Hepatitis B virus / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism / Q000494:pharmacology*; D007700:Kinetics; D008081:Liposomes; D008113:Liver Neoplasms; D011971:Receptors, Immunologic / Q000378:metabolism*; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D013696:Temperature; D014779:Virus Replication / Q000187:drug effects*; D000509:alpha-Fetoproteins
chemical_list: D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins; D004337:Drug Carriers; D060748:Fetuins; D008081:Liposomes; D011971:Receptors, Immunologic; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D000509:alpha-Fetoproteins; C017029:asialofetuin; D007371:Interferon-gamma