title: [Amplification of L-myc oncogene in malignant meningioma. Case report].
abstract: Amplification of L-myc oncogene was noticed in a malignant meningioma originating from the right sphenoidal wing of a 54-year-old female. The patient underwent three surgical resections plus radiotherapy over a period of 11 years and then the growth rate of the tumor became much greater with a severely invasive appearance. Using Southern blot hybridization, L-myc amplification was examined on the specimen resected at the fourth operation. As a result, approximately five-fold amplification was confirmed, which has not been previously reported except for that in a small cell carcinoma of the lung. This result may suggest that L-myc amplification is responsible to some extent for the malignant transformation in this meningioma.
authors.affiliation: Department of Microbiology, University of Tsukuba, Ibaraki.
authors.forename: T
authors.initials: T
authors.lastname: Jimbo
authors.forename: K
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamura
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: K
authors.initials: K
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Nose
mesh_terms: D005260:Female; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged