[The toxic and immunomodulating properties of the somatic O-antigen polysaccharide of typhoid bacteria].
In experiments on random bred mice and mice of various strains it was shown that when administered parenterally typhoid bacteria O-somatic antigen polysaccharide possesses the immunomodulatory properties. It stimulates the non-specific resistance of the organism to bacterial infection, produces the polyclonal activation of beta-lymphocytes, possesses the adjuvant properties, activates cells of the mononuclear phagocytic system. At administration in therapeutic doses the drug is not toxic, possesses no carcinogenic, mutagenic and allergenic properties.
Duplishcheva
A P
AP
Sinilova
N G
NG
Kharitonova
A M
AM
Bykovskaia
S I
SI
Grigor'eva
L V
LV
Snegireva
A E
AE
Shaposhnikova
G V
GV
Andreeva
I V
IV
Rusina
O Iu
OIu
D000276:Adjuvants, Immunologic / Q000494:pharmacology / Q000633:toxicity*; D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology / Q000633:toxicity*; D003043:Cocarcinogenesis; D006168:Guinea Pigs; D007113:Immunity, Innate / Q000187:drug effects / Q000276:immunology; D007928:Lethal Dose 50; D007942:Leukemia, Experimental / Q000209:etiology; D051379:Mice; D009152:Mutagenicity Tests; D019081:O Antigens; D011135:Polysaccharides, Bacterial / Q000276:immunology / Q000633:toxicity*; D051381:Rats; D011925:Rauscher Virus; D012485:Salmonella typhi / Q000276:immunology*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D019081:O Antigens; D011135:Polysaccharides, Bacterial; C029023:salmozan
Toksicheskie i immunomoduliruiushchie svoĭstva polisakharida O-somaticheskogo antigena bakteriĭ briushnogo tifa.