Ion influx as a transduction signal in mast cells.
Stimulation of mast cells leads to a transient increase in the concentration of free intracellular calcium, which, in a fraction of cells, is followed by a plateau of elevated calcium. The early part of this signal is due to release of calcium from intracellular stores. It is not important for secretion. The late plateau phase, if present, greatly accelerates secretion. It is mediated by two influx pathways, one of which can be identified as a nonspecific cationic channel.
Neher
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Max-Planck-Institut für Biophysikalische Chemie, Göttingen, FRG.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015550:Cell Degranulation; D006801:Humans; D007473:Ion Channels / Q000502:physiology; D008407:Mast Cells / Q000378:metabolism*; D015398:Signal Transduction
D007473:Ion Channels; D002118:Calcium