[Ciprofloxacin concentration in human prostatic tissue following 3 days' administration].
The penetration of Ciprofloxacin (CPFX) into the prostatic tissue and the serum was examined. Forty-four patients with benign prostatic hypertrophy treated with transurethral resection of the prostate were entered in this study. CPFX was administered orally in a dose of 200 mg three times daily for three days preoperatively. The blood samples were taken simultaneously at the time of the tissue sampling. The patients were divided into groups 1 and 2. In group 1 (16 patients), the tissue sampling was done about 17 hours after the final drug administration. The mean concentration of CPFX was 0.61 +/- 0.40 microgram/g in the prostatic tissue and 0.27 +/- 0.19 micrograms/ml in the serum. In group 2 (28 patients), tissue sampling was done 5.5 hours after the final drug administration. The mean concentration of CPFX was 1.32 +/- 0.64 micrograms g in the prostatic tissue and 0.65 +/- 0.31 microgram/ml in the serum.
Morita
M
M
Department of Urology, Sendai Social Insurance Hospital.
Nakagawa
H
H
Suzuki
K
K
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011467:Prostate / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000601:surgery; D013997:Time Factors
D002939:Ciprofloxacin