title: [Rationale for using kinin system inhibitors in patients with acute ischemia and infarction of the myocardium during the prehospital phase].
abstract: The paper discusses if it is advisable to use kallikrein-kinin system inhibitors earlier. A total of 122 patients with acute ischemia and infarction of the myocardium were studied. Contrykal and heparin infused in the prehospital period, followed by hospital treatment are optimal to prevent vascular wall lesions, maximally retain retrograde blood flow, and substantially reduce the size of myocardial infarction. Therapy with protease inhibitors proved to be most beneficial within the first 2 hours of the disease, as evidenced by a profound improvement in the clinical course of myocardial infarction, a decrease in ECG and precordial mapping signs of ischemia, a positive change in myoglobin and MB creatine phosphokinase levels, and a significant reduction in the rehabilitative period.
authors.forename: A A
authors.initials: AA
authors.lastname: Korotkov
authors.forename: G G
authors.initials: GG
authors.lastname: Iremadze
authors.forename: T D
authors.initials: TD
authors.lastname: Zhorzholiani
authors.forename: R B
authors.initials: RB
authors.lastname: Kurashvili
authors.forename: M D
authors.initials: MD
authors.lastname: Mamatsashvili
authors.forename: M P
authors.initials: MP
authors.lastname: Dzhibladze
authors.forename: T I
authors.initials: TI
authors.lastname: Chumburidze
authors.forename: L G
authors.initials: LG
authors.lastname: Chkheidze
authors.forename: L P
authors.initials: LP
authors.lastname: Kochlamazashvili
authors.forename: D R
authors.initials: DR
authors.lastname: Sagaradze
mesh_terms: D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000008:administration & dosage / Q000627:therapeutic use*; D004796:Clinical Enzyme Tests; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D004632:Emergency Medical Services; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D006493:Heparin; D007611:Aprotinin
vernacular_title: Ob obosnovannosti ispol'zovaniia na dogospital'nom étape ingibitorov kininovoĭ sistemy u bol'nykh s ostroĭ ishemieĭ i infarktom miokarda.