The new potent immunosuppressant FK-506 reverses multidrug resistance in Chinese hamster ovary cells.
The macrolide FK-506, produced by Streptomyces tsukubaensis, is effective in sensitizing a multidrug resistant strain of Chinese hamster ovary cells to the cytotoxic action of vinblastine. FK-506 also promotes Adriamycin accumulation into both wild type and resistant cell lines. FK-506 may be a useful drug to enhance the effectiveness of anti-tumour cytotoxic drugs.
Epand
R F
RF
Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
Epand
R M
RM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000378:metabolism; D004351:Drug Resistance; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016559:Tacrolimus; D014747:Vinblastine / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D014747:Vinblastine; D004317:Doxorubicin; D016559:Tacrolimus