title: An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15.
abstract: A human hair cuticle ultrahigh-sulphur keratin Q (UHSK) gene (KRN1) has been mapped by Southern analysis of a somatic cell hybrid panel and by in situ hybridization. A probe containing the coding region of this gene mapped to 11pter- greater than 11q21 using the hybrid cell panel and on in situ hybridization mapped to two regions on chromosome 11: the distal part of 11p15, most likely 11p15.5, and the distal part of 11q13, most likely 11q13.5. A probe from the 3' noncoding region of KRN1 mapped to 11q13.5 indicating that this was the map location of the cloned gene. The sequence of 11p15.5 is termed KRN1-like (KRN1L). The results reveal that the cuticle UHSK gene family is clustered in the human genome.
authors.affiliation: Department of Biochemistry, University of Adelaide, Australia.
authors.forename: P J
authors.initials: PJ
authors.lastname: MacKinnon
authors.forename: B C
authors.initials: BC
authors.lastname: Powell
authors.forename: G E
authors.initials: GE
authors.lastname: Rogers
authors.forename: E G
authors.initials: EG
authors.lastname: Baker
authors.forename: R N
authors.initials: RN
authors.lastname: MacKinnon
authors.forename: V J
authors.initials: VJ
authors.lastname: Hyland
authors.forename: D F
authors.initials: DF
authors.lastname: Callen
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
mesh_terms: D015139:Blotting, Southern; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007633:Keratins / Q000235:genetics*; D009693:Nucleic Acid Hybridization
chemical_list: D007633:Keratins