[The effect on the cerebral microcirculation of in vivo stains used in biomicroscopy].
Vasoactive properties of semi-colloidal acid stains of the Evan blue and tripane blue, were revealed in rabbits and rats. The microphoto-technique revealed a dose-depending vasodilating effect of the stains. The response of the arteries had sometimes a biphasic character: constriction--dilation. I. v. administration of the stains induced a dose-dependent significant reduction of local blood flow in the cortex, subcortical white substance and other parts of the brain, of total cerebral blood flow in the venous sinus; a drop of systemic arterial pressure in normo- and hypertensive animals; a change in cerebral bioelectrical activity with increasing theta-waves, appearance of spikes and polyspikes in the EEG. Acting upon the formation of vascular tonus, these stains can interfere with the mechanisms of regulation of cerebral blood flow.
Riasina
T V
TV
Komm
S G
SG
Vaĭnshteĭn
G B
GB
Galaĭda
T V
TV
Iripkhanov
B B
BB
Famelis
S A
SA
Engovatov
V V
VV
Krivchenko
A I
AI
Moskalenko
Iu E
IuE
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects; D005070:Evans Blue / Q000494:pharmacology*; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000502:physiology; D005260:Female; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013194:Staining and Labeling / Q000379:methods; D014343:Trypan Blue / Q000494:pharmacology*
D005070:Evans Blue; D014343:Trypan Blue
Vliianie na mikrotsirkuliatsiiu mozga nekotorykh prizhiznennykh krasiteleĭ, ispol'zuemykh pri biomikroskopii.