[Histochemical model investigations of the action mechanisms of lathyrogenic substances].
In histochemical model studies, aminoacetonitrile and 3-aminopropionitrile can form hydrolysis-stable azomethines (Schiff bases) with periodate-induced aldehyde groups of tissue slices. Both substances and triethylentetramine do not inhibit the histochemical monoaminoxidase activity, they even can act as substrates of this enzyme. These substances cause an inhibition of the histochemical aminopeptidase M activity, but this inhibition was recognized as a methodological error due to the formation of complexes between diazonium salts and aliphatic amines. The results indicate that the inhibition of the lysyl oxidase will not be the only mechanism of action of lathyrogenic substances.
Seidler
E
E
Institut für Anatomie, Humboldt-Universität zu Berlin, BRD.
Wendler
D
D
Gabler
W
W
D000607:Aminoacetonitrile / Q000494:pharmacology*; D000626:Aminopeptidases / Q000037:antagonists & inhibitors; D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D018826:CD13 Antigens; D003979:Diazonium Compounds; D006651:Histocytochemistry; D007842:Lathyrism / Q000139:chemically induced / Q000473:pathology*; D008996:Monoamine Oxidase Inhibitors; D008249:Protein-Lysine 6-Oxidase / Q000037:antagonists & inhibitors; D051381:Rats; D013194:Staining and Labeling; D014266:Trientine / Q000494:pharmacology*
D003979:Diazonium Compounds; D008996:Monoamine Oxidase Inhibitors; D000629:Aminopropionitrile; D000607:Aminoacetonitrile; D008249:Protein-Lysine 6-Oxidase; D000626:Aminopeptidases; D018826:CD13 Antigens; D014266:Trientine
Histochemische Modellversuche zum Wirkungsmechanismus lathyrogener Substanzen.