The effect of gamma-hexachlorocyclohexane (lindane) on blood cells, kidney and liver tissues in rabbits.
The effect of intragastric administration of gamma-hexachlorocyclohexane (lindane) on peripheral blood cells, kidney and liver was studied in rabbits. White blood cells were found to be most affected by lindane, as was shown by the reduced phagocytic activity of neutrophils and the increased number of lymphocytes with inactive nucleoli. The changes in the characteristics of erythrocyte cell membranes depended on the length of time lindane was administered and on its withdrawal. Histological examination of the liver and kidney showed focal degeneration of tissue and cell structure.
Grabarczyk
M
M
Institute of Hematology, Department of Physiopathology, Warsaw, Chocimska, Poland.
Kopeć-Szlezak
J
J
Szczepańska
I
I
Woźniak
J
J
Podstawka
U
U
D000818:Animals; D001772:Blood Cell Count; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D006400:Hematocrit; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects; D007928:Lethal Dose 50; D007962:Leukocytes / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors
D001556:Hexachlorocyclohexane