[The delta sleep-inducing peptide as a factor enhancing the content of substance P in the hypothalamus and the resistance of rats to emotional stress].
The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line. DSIP administration significantly increased the mean SP content in the hypothalamus and also its content in animals, stable and predisposed to emotional stress. Daily DSIP administration before putting the rats in conditions of stress increased the SP content in the hypothalamus decreased at the emotional stress. Preliminary single DSIP administration to the animals subjected to stress also increased the SP content. Single DSIP administration in a dose of 60 nmol/kg sharply reduced classical stress manifestations, such as hypertrophy of adrenals and thymus involution.
Salieva
R M
RM
Ianovskiĭ
K
K
Ratsak
R
R
Trofimova
Ia I
IaI
Oehme
P
P
Sudakov
K V
KV
Iumatov
E A
EA
D000818:Animals; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology* / Q000517:prevention & control; D013373:Substance P / Q000032:analysis / Q000187:drug effects* / Q000502:physiology
D013373:Substance P; D003701:Delta Sleep-Inducing Peptide
Peptid, vyzyvaiushchiĭ del'ta-son, kak faktor, povyshaiushchiĭ soderzhanie veshchestva P v gipotalamuse i ustoĭchivost' krys k émotsional'nomu stressu.