title: Disruption of keratin intermediate filaments by ultraviolet radiation in cultured human keratinocytes.
abstract: Fluorescence microscopy has been utilized to investigate the effects of UV irradiation on the organization of keratin intermediate filaments in normal human epidermal keratinocytes. Sun lamp irradiation induced the condensation of keratin intermediate filaments into the perinuclear region and inhibited the reorganization of keratin filaments normally induced by Ca2+. Exposure to UVC appeared to disrupt keratin filaments similarly, whereas UVA had no discernible effect.
authors.affiliation: Department of Microbiology, Boston University School of Medicine, MA 02118.
authors.forename: G B
authors.initials: GB
authors.lastname: Zamansky
authors.forename: I N
authors.initials: IN
authors.lastname: Chou
mesh_terms: D002478:Cells, Cultured; D006801:Humans; D015603:Keratinocytes / Q000528:radiation effects*; D007633:Keratins / Q000528:radiation effects*; D014466:Ultraviolet Rays
chemical_list: D007633:Keratins