title: [Progressive multifocal leukoencephalopathy (PML) in AIDS: morphological and topographical characteristics].
abstract: 15 autopsy cases of PML in AIDS are presented. Frequent findings were: Very large, confluent PML-lesions (7 cases), lesions with prominent necrotic features (10 cases) and with marked perivascular mononuclear infiltrates (6 cases). In 9 cases additional PML-foci were seen in the cerebellum and/or the brain stem, and in 1 case there was even an exclusive involvement of those structures. Such characteristics regarding severity and topography of PML in AIDS, may be due to additional toxic factors. In 7 cases HIV-encephalopathy with multinucleated macrophages was present.
authors.affiliation: Institut für Neuropathologie, Universität Münster.
authors.forename: K
authors.initials: K
authors.lastname: Kuchelmeister
authors.forename: F
authors.initials: F
authors.lastname: Gullotta
authors.forename: M
authors.initials: M
authors.lastname: Bergmann
authors.forename: G
authors.initials: G
authors.lastname: Angeli
authors.forename: T
authors.initials: T
authors.lastname: Masini
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000473:pathology*; D000328:Adult; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D001933:Brain Stem / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology / Q000473:pathology*; D008297:Male
vernacular_title: Die progressive multifokale Leukoenzephalopathie (PML) bei AIDS: Morphologische und topographische Besonderheiten.