title: Dual radioisotopic study: a technique for the evaluation of vasculogenic impotence.
abstract: Arterial and venous systems are the main points for the evaluation of vasculogenic impotence. To evaluate both of these systems in the same study we propose a dual radioisotopic study in which 99mtechnetium (99mTc) and 133xenon (133Xe) were used. The changes in 99mTc and 133Xe radioactivities administered intravenously and intracavernously, respectively, were monitored before and after intracavernous papaverine injection. These changes were determined as time activity curves, which were generated from the region of interest over the penis. A 99mTc penogram index derived from the 99mTc time activity curve was significantly different in the control and arteriogenic impotence groups (131.67 +/- 74.6 versus 62.94 +/- 51.6, p less than 0.01). A meaningful correlation between 99mTc penogram index results and duplex ultrasonographic findings were observed (r = 0.905). 133Xe penogram index, derived from the 133Xe washout curve was significantly different in the control and venogenic impotence groups (-25.65 +/- 24.9 versus -56.09 +/- 13.4, p less than 0.01). Also, a meaningful correlation was obtained between pharmacocavernosometry and 133Xe penogram index results of venogenic impotent patients (r = 0.86). These findings suggest that the dual radioisotopic study will be a useful technique in the evaluation of the entire vascular system of the penis, since it is a noninvasive method.
authors.affiliation: Department of Urology, Hacettepe University School of Medicine, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Esen
authors.forename: M
authors.initials: M
authors.lastname: Kitapci
authors.forename: A
authors.initials: A
authors.lastname: Ergen
authors.forename: B
authors.initials: B
authors.lastname: Erbas
authors.forename: D
authors.initials: D
authors.lastname: Remzi
authors.forename: C
authors.initials: C
authors.lastname: Bekdik
mesh_terms: D000328:Adult; D001158:Arteries / Q000503:physiopathology; D001783:Blood Flow Velocity; D007172:Erectile Dysfunction / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000494:pharmacology; D010410:Penile Erection / Q000187:drug effects; D010413:Penis / Q000098:blood supply* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013667:Technetium; D014680:Veins / Q000503:physiopathology; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes; D013667:Technetium; D010208:Papaverine