Role of endogenous endothelin in the development of hypertension in rats.
To further elucidate the pathophysiologic role of endogenous endothelin (ET), we have studied the chronic effect of anti-ET gamma-globulin on the development of hypertension in spontaneously hypertensive rats (SHR) and stroke prone SHR (SHR-SP) for three weeks. In neither SHR nor SHR-SP did repetitive bolus injection of anti-ET gamma-globulin suppress the rise in blood pressure. The present data suggest that endogenous ET is not likely to play a key role in the development of hypertension, although ET may induce a local vasoconstriction at the injured vascular wall.
Takagi
Y
Y
Department of Medicine, Kobe University School of Medicine, Japan.
Fukase
M
M
Takata
S
S
Kawakami
M
M
Masui
M
M
Ueda
M
M
Fujita
T
T
D000818:Animals; D016232:Endothelins / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D014661:Vasoconstriction / Q000502:physiology; D005719:gamma-Globulins / Q000008:administration & dosage
D016232:Endothelins; D005719:gamma-Globulins