Induction of sperm abnormalities in mice by norfloxacin.
Norfloxacin was tested in the mouse sperm morphology test. Data obtained suggest that norfloxacin may have 2 different effects on sperm development: a stimulating effect on spermatogenesis and a possible mutagenic effect that results in an increase in sperm abnormalities. The first effect might be caused by a hormonal action. A dose-response relationship was not observed in sperm morphology changes. Consequently norfloxacin cannot with certainty be judged a positive inducer of abnormal sperm, but further studies are essential to clarify the obtained results.
Maura
A
A
Institute of Pharmacology, University of Genoa, Italy.
Pino
A
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D008741:Methyl Methanesulfonate / Q000633:toxicity; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009643:Norfloxacin / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects
D009153:Mutagens; D008741:Methyl Methanesulfonate; D009643:Norfloxacin