Genetic conservation of cyclo-oxygenase.
Homology between sheep and mouse cyclo-oxygenase cDNA and a range of other species was investigated using "zoo blots". Both the sheep and mouse cDNAs showed a high degree of homology to other species. Human cyclooxygenase appears to have greater homology to sheep and other ruminants than to mouse. Both sheep and mouse cDNAs detected identically sized transcripts in human placental total RNA.
Bennett
P R
PR
Action Research Laboratory For The Molecular Biology of Fetal Development, Royal Post Graduate Medical School, Queen Charlottes and Chelsea Hospital, London, England.
Moore
G E
GE
D000818:Animals; D005075:Biological Evolution; D015139:Blotting, Southern; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D006801:Humans; D051379:Mice; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D012756:Sheep
D012313:RNA; D004247:DNA; D011451:Prostaglandin-Endoperoxide Synthases