Effect of pituitary adenylate cyclase activating polypeptide on rat pancreatic exocrine secretion.
A novel neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), which has been isolated from ovine hypothalami, shows 68% homology with vasoactive intestinal peptide (VIP). Since VIP stimulates amylase secretion from the pancreas, we investigated the effect of PACAP and VIP on rat pancreatic exocrine secretion after intravenous injections of PACAP-27, PACAP-38, or VIP at doses of 2.5, 5 or 10 nmol/kg. Results showed: 1) Bolus injection of PACAP stimulated pancreatic amylase and protein secretions in a dose-dependent manner; and 2) Stimulation of amylase secretion with 10 nmol/kg of PACAP-27 was greater than that induced with the same dose of VIP or PACAP-38 (p less than 0.05).
Mungan
Z
Z
Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112.
Ertan
A
A
Hammer
R A
RA
Arimura
A
A
D000262:Adenylyl Cyclases / Q000378:metabolism; D000681:Amylases / Q000378:metabolism; D000818:Animals; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011506:Proteins / Q000378:metabolism; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011506:Proteins; D014660:Vasoactive Intestinal Peptide; D000681:Amylases; D000262:Adenylyl Cyclases