Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102.
The Aspergillus mycotoxins ochratoxin A and B, citrinin and patulin as well as combinations of ochratoxin A and citrinin did not induce reverse mutations in Salmonella typhimurium strain TA102. Therefore there is no indication for the induction of oxidative damage or crosslinks. The same is true for cnestine, a compound extracted from the plant Cnestis glabra.
Würgler
F E
FE
Institute of Toxicology, Swiss Federal Institute of Technology, Zürich.
Friederich
U
U
Schlatter
J
J
D001711:Biotransformation; D002953:Citrinin / Q000633:toxicity*; D003432:Cross-Linking Reagents; D008717:Methionine Sulfoximine / Q000633:toxicity*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009793:Ochratoxins / Q000633:toxicity*; D010084:Oxidation-Reduction; D010365:Patulin / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D003432:Cross-Linking Reagents; D009153:Mutagens; D009793:Ochratoxins; C025589:ochratoxin A; D008717:Methionine Sulfoximine; D002953:Citrinin; D010365:Patulin; C045354:ochratoxin B