Response of the endolymphatic sac d.c. potential to asphyxia.
The effect of asphyxia on the endolymphatic sac d.c. potential (ESP) was examined in the guinea pig. Asphyxia was caused for 1.5 min by stopping the respirator. The ESP decreased in amplitude during asphyxia. After the termination of asphyxia the ESP showed a diphasic recovery pattern. When respiration was resumed, the ESP decreased again following a transient recovery. Thereafter, the ESP showed a gradual recovery. beta-blocker (propranolol) inhibited a temporary decrease in the ESP after the resumption of respiration, but not alpha-blocker (phentolamine). The result indicates that the ESP decrease after the resumption of respiration is induced by beta-adrenergic action.
Mori
N
N
Department of Otolaryngology, Kagawa Medical School, Japan.
Uozumi
N
N
Sakai
S
S
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001237:Asphyxia / Q000503:physiopathology*; D001693:Biological Transport, Active / Q000502:physiology; D004712:Endolymphatic Sac / Q000502:physiology*; D006168:Guinea Pigs; D007473:Ion Channels / Q000502:physiology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*
D007473:Ion Channels; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D010646:Phentolamine