Chromosome 11 rearrangement at band 11q21 in a patient with essential thrombocythemia.
A case of essential thrombocythemia with a partial deletion of the long arm of chromosome 11, del(11)(q21) as a sole chromosomal anomaly is reported. Rearrangement of chromosome 11 at band 11q21 has been reported in six patients with chronic myeloproliferative disorders: four with post-polycythemic myelofibrosis, one with myelofibrosis with myeloid metaplasia, and one with Ph+ chronic myeloid leukemia in blastic phase. Except for the last patient, all patients had been treated with 32P and/or an alkylating agent prior to cytogenetic examination. This is the first report of the 11q21 abnormality in essential thrombocythemia seen at diagnosis.
Nakamura
H
H
Department of Hematology, Nagasaki University School of Medicine, Japan.
Hayashibara
T
T
Kawachi
T
T
Nagai
K
K
Matsuo
T
T
Sadamori
N
N
Tomonaga
M
M
D000328:Adult; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D008297:Male; D013920:Thrombocythemia, Essential / Q000235:genetics*