title: Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.
abstract: Peptides from donor major histocompatibility complex (MHC) molecules were examined for their activation of allogeneically primed T cells. After immunization with either allogeneic spleen cells or a skin allograft, primed T cells proliferate in response to peptides derived from polymorphic regions of alpha and beta chains of class II allo-MHC molecules. The results demonstrate that presentation of donor-MHC peptides by host-derived antigen-presenting cells is a common event in vivo. Thus, self-restricted T cell recognition of processed alloantigens may play a critical role in transplantation. An in-depth understanding of this response may result in the development of additional molecular therapies to combat allograft rejection.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of California Los Angeles 90024.
authors.forename: G
authors.initials: G
authors.lastname: Benichou
authors.forename: P A
authors.initials: PA
authors.lastname: Takizawa
authors.forename: C A
authors.initials: CA
authors.lastname: Olson
authors.forename: M
authors.initials: M
authors.lastname: McMillan
authors.forename: E E
authors.initials: EE
authors.lastname: Sercarz
mesh_terms: D000818:Animals; D006084:Graft Rejection; D006649:Histocompatibility Antigens / Q000276:immunology; D007700:Kinetics; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006649:Histocompatibility Antigens