Synthesis, stability, and biological evaluation of water-soluble prodrugs of a new echinocandin lipopeptide. Discovery of a potential clinical agent for the treatment of systemic candidiasis and Pneumocystis carinii pneumonia (PCP).
Balkovec
J M
JM
Department of Synthetic Chemical Research, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
Black
R M
RM
Hammond
M L
ML
Heck
J V
JV
Zambias
R A
RA
Abruzzo
G
G
Bartizal
K
K
Kropp
H
H
Trainor
C
C
Schwartz
R E
RE
D000107:Acetylation; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002177:Candidiasis / Q000188:drug therapy*; D054714:Echinocandins; D006801:Humans; D051379:Mice; D008811:Mice, Inbred DBA; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D010456:Peptides, Cyclic; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D000935:Antifungal Agents; D054714:Echinocandins; D010455:Peptides; D010456:Peptides, Cyclic; D011355:Prodrugs; C042101:cilofungin