Effect of MK-801 on focal brain infarction in normotensive and hypertensive rats.
The effects of the noncompetitive N-methyl-D-aspartate antagonist MK-801 on infarct size and systemic variables after middle cerebral artery occlusion in spontaneously hypertensive and Fischer-344 rats were investigated. Two doses (0.5 and 5 mg/kg) administered before the induction of ischemia were studied. MK-801 significantly reduced the neocortical volume of infarction (by about 32% at both doses) in Fischer-344 rats and had no neuroprotective effects in the striatum. In contrast, MK-801 had no significant influence on either cortical or striatal infarcted volume in spontaneously hypertensive rats. The reduction or lack of MK-801-induced neuroprotection in spontaneously hypertensive rats, as compared with Fischer-344 rats, could be attributed to a reduced collateral supply in the marginal area due to difference in the morphology of the pial anastomoses and/or in the effects of ischemia and treatment on arterial pressure. The results may have major clinical implications since a great proportion of human strokes are associated with hypertension.
Roussel
S
S
Laboratoire de Recherches Cérébrovasculaires, UA 641 C.N.R.S., Université Paris VII, France.
Pinard
E
E
Seylaz
J
J
D000818:Animals; D001158:Arteries; D001831:Body Temperature / Q000187:drug effects; D002544:Cerebral Infarction / Q000473:pathology* / Q000503:physiopathology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000097:blood; D051381:Rats; D011916:Rats, Inbred F344; D011918:Rats, Inbred SHR; D012016:Reference Values
D016291:Dizocilpine Maleate; D010100:Oxygen