title: Deconvolution study of the absorption rate and disposition kinetic values of lindane in sheep.
abstract: Absorption rate and plasma and fat disposition of lindane after various lindane percutaneous treatments in shorn and unshorn sheep were investigated. To analyze data with a deconvolution method, IV administration was performed to determine the basic pharmacokinetic values of lindane in sheep. After IV administration, the steady state volume of distribution was very high (8.07 +/- 3.60 L/kg of body weight), and the mean residence time was long (28.1 +/- 11.7 hours). Deconvolution analysis indicated that lindane absorption was continuous until 33 to 41 days after spraying with a 0.025% lindane solution. Total amount of absorbed lindane in shorn (15,171 +/- 4,463 micrograms/kg) sheep was about twice that in unshorn (7,615 +/- 3,128 micrograms/kg) sheep; from deconvolution analysis, it was calculated that the time required for 50% of the available dose to be absorbed was between 115 and 179 hours. After percutaneous lindane administration, the fat concentration was compared with the available lindane dose. The apparent half-life of lindane elimination in fat was 225 +/- 47.4 hours, which is similar to the value calculated for the absorption rate constant. By comparing fat and plasma concentrations, it was calculated that for a mean plasma concentration of 5 ng/ml, the fat lindane concentration was 1.65 +/- 0.87 micrograms/g (ie, lower than the generally accepted tolerance level of 2 micrograms/g).
authors.affiliation: Centre National d'Etudes Vététinaires et Alimentaires, Laboratoire des Médicaments Vétérinaires, Fougeres, France.
authors.forename: M
authors.initials: M
authors.lastname: Dagorn
authors.forename: P
authors.initials: P
authors.lastname: Guillot
authors.forename: P
authors.initials: P
authors.lastname: Sanders
authors.forename: M
authors.initials: M
authors.lastname: Laurentie
authors.forename: P L
authors.initials: PL
authors.lastname: Toutain
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D007275:Injections, Intravenous / Q000662:veterinary; D012756:Sheep / Q000378:metabolism*
chemical_list: D001556:Hexachlorocyclohexane