title: [Hormonal changes and biologically active substances in alcoholic women in the reproductive age].
abstract: The levels of hormones and some bioactive substances were measured in women of a reproductive age, suffering from alcoholism, with different stages and duration of this condition. Studies of the serotonin-reactive, cholinergic, and cholino-reactive systems have shown a discordant activity of the neuromediator systems: reduced activity of the serotonin-reactive and elevated tone of the cholinergic systems. The findings evidence that chronic alcohol poisoning is associated with activation of the hypothalamohypophyseal system followed by depression of this activity with the progress of alcoholism. Alcoholism involves disordered functioning of the ovaries, thyroid, and adrenals; these disorders may augment due to direct toxic effect of alcohol and its metabolites on the endocrine glands. All this eventuates in menstrual dysfunction and infertility.
authors.forename: L V
authors.initials: LV
authors.lastname: Akker
mesh_terms: D000109:Acetylcholine / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000437:Alcoholism / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D010908:Pituitary Hormones, Anterior / Q000097:blood; D012701:Serotonin / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D010908:Pituitary Hormones, Anterior; D013963:Thyroid Hormones; D012701:Serotonin; D000450:Aldosterone; D006897:Hydroxyindoleacetic Acid; D000109:Acetylcholine; D006854:Hydrocortisone
vernacular_title: Gormonal'nye izmeneniia i bilogicheski aktivnye veshchestva u zhenshchin reproduktivnogo vozrasta, stradaiushchikh alkogolizmom.