title: Prostatic acid phosphatase, beta-glucuronidase and prostate specific antigen assays in fine needle aspirates from benign and malignant prostates.
abstract: Enzymatic assays for tartrate-sensitive acid phosphatase and beta-glucuronidase, and radio-immunoassay for prostate-specific antigen, were modified for application to fine-needle aspirate samples from benign and malignant human prostates. When compared to samples from benign prostates, the ratio of acid phosphatase to beta-glucuronidase activities was significantly decreased in needle aspirates from malignant prostates. Prostate-specific antigen values in the aspirates did not correlate with malignancy.
authors.affiliation: Department of Surgery, University of Texas Health Science Center, San Antonio.
authors.forename: D R
authors.initials: DR
authors.lastname: Erickson
authors.forename: T C
authors.initials: TC
authors.lastname: Hlavinka
authors.forename: A P
authors.initials: AP
authors.lastname: Rockwood
authors.forename: J D
authors.initials: JD
authors.lastname: Metter
authors.forename: D E
authors.initials: DE
authors.lastname: Novicki
authors.forename: M G
authors.initials: MG
authors.lastname: Fried
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000737:chemistry*; D001707:Biopsy, Needle; D004796:Clinical Enzyme Tests / Q000379:methods*; D005966:Glucuronidase / Q000032:analysis*; D006801:Humans; D008297:Male; D011467:Prostate / Q000201:enzymology* / Q000276:immunology / Q000473:pathology; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D000135:Acid Phosphatase; D005966:Glucuronidase; D017430:Prostate-Specific Antigen