[Activity of human natural killer cells against target cells possessing different sensitivity to interferon].
The cytotoxic activity of peripheral blood natural killers (NK) against target cells (TC) J-96 and L-929 with high sensitivity to interferon (IFN) action, J-41 and MCB resistant to IFN action and line K-562 labelled by H3-uridine was studied in 14 hrs cytotoxic test. It has been shown that human TC J-96 didn't differ from the J-41 in their sensitivity to NK cytotoxicity and they are strongly resistant to NK than TC K-562. The murine TC L-929 as the human TC didn't differ from the MCB in their sensitivity to NK lysis and had also the same sensitivity to NK as the K-562 cells.
Cheknev
S B
SB
Narovlianskiĭ
A N
AN
Amchenkova
A M
AM
Sorokin
A M
AM
Khesin
Ia E
IaE
Ershov
F I
FI
D000818:Animals; D002460:Cell Line; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D014407:Tumor Cells, Cultured / Q000276:immunology
D007372:Interferons
Aktivnost' estestvennykh killerov cheloveka protiv kletok-misheneĭ, obladaiushchikh razlichnoĭ chuvstvitel'nost'iu k interferonu.