Effects of synthetic human pancreastatin on pancreatic secretion and blood flow in rats and dogs.
Effects of synthetic human pancreastatin-52 and human pancreastatin-29 on pancreatic secretion and blood flow were examined in rats and dogs. Synthetic human pancreastatin-52 and human pancreastatin-29 were equally potent in suppressing the release of amylase stimulated by cholecystokinin in rats in vivo. However, neither human pancreastatin-52 nor human pancreastatin-29 altered basal and cholecystokinin-stimulated amylase release from isolated dispersed rat pancreatic acini. In studies in dogs, human pancreastatin-29 suppressed releases of amylase and protein stimulated by cholecystokinin, but did not alter pancreatic blood flow. These results suggest that the inhibitory effects of pancreastatin on pancreatic secretion do not involve a direct action on pancreatic acinar cells nor alteration of pancreatic blood flow. Pancreastatin probably is important in regulating exocrine pancreatic secretions as well as endocrine pancreatic secretions.
Doi
R
R
First Department of Surgery, Kyoto University Faculty of Medicine, Japan.
Inoue
K
K
Hosotani
R
R
Higashide
S
S
Takaori
K
K
Funakoshi
S
S
Yajima
H
H
Rayford
P L
PL
Tobe
T
T
D000681:Amylases / Q000378:metabolism; D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010179:Pancreas / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D010187:Pancreatic Hormones / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011994:Recombinant Proteins / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects
D010187:Pancreatic Hormones; D010446:Peptide Fragments; D011506:Proteins; D011994:Recombinant Proteins; C071102:pancreastatin-52; C071103:pancreastatin-29; D002766:Cholecystokinin; D000681:Amylases