Lead and immunity: II. Suppression of humoral immune response to Hymenolepis nana in mice.
Serum protein changes in mice treated for varying durations with lead nitrate and subsequently infected with 1000 H. nana eggs were compared with their counterpart controls, only treated and only infected groups. Decreased values of beta and gamma globulins in all the experimental groups along with higher worm recoveries indicate suppression of humoral immune response by lead in association with higher worm recoveries indicate suppression of humoral immune response by lead in association with the cellular components since these globulins are known to contain antibodies. Lead treatment for a duration of 45 days proved to be most effective in suppressing the immune response.
Khanna
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R
Helminthology-Immunology Laboratory, School of Studies in Zoology, Vikram University, Ujjain, India.
Johri
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GN
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis*; D000917:Antibody Formation / Q000187:drug effects; D001609:Beta-Globulins / Q000032:analysis; D005260:Female; D006926:Hymenolepis / Q000276:immunology*; D007108:Immune Tolerance; D007854:Lead / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D012709:Serum Albumin / Q000032:analysis; D005719:gamma-Globulins / Q000032:analysis
D000909:Antibodies, Helminth; D001609:Beta-Globulins; D012709:Serum Albumin; D005719:gamma-Globulins; D007854:Lead