title: [The characteristics of the reactogenicity and immunological activity of a new cholera bivalent chemical vaccine based on the results of controlled trials].
abstract: The reactogenic properties and immunological potency of modified cholera chemical vaccine (choleragen-toxoid + O-antigens Inaba and Ogawa) were tested in 278 volunteers aged 18 years and over in comparison with those of a commercial batch of monovalent cholera vaccine (choleragen-toxoid + O-antigen Inaba). The cholera vaccine, enriched with O-antigen Ogawa, was found to be safe; vaccination with this vaccine was not accompanied by the development of systemic and local reactions whose frequency and intensity met the requirements for the reactogenic properties of commercial cholera vaccine. The immunological potency of the bivalent vaccine with respect to strain Inaba was not inferior to that of the commercial vaccine; at the same time in persons immunized with the new preparation the titers of vibriocidal antibodies to strain of serovar Inaba were five-fold higher. The conclusion on the expediency of using cholera chemical vaccine enriched with O-antigen Ogawa was made.
authors.forename: A A
authors.initials: AA
authors.lastname: Sumarokov
authors.forename: N R
authors.initials: NR
authors.lastname: Ivanov
authors.forename: M N
authors.initials: MN
authors.lastname: Dzhaparidze
authors.forename: E A
authors.initials: EA
authors.lastname: Rystsova
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Reznikov
authors.forename: L Ia
authors.initials: LIa
authors.lastname: Matusevich
authors.forename: G P
authors.initials: GP
authors.lastname: Nikitina
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Eliseev
authors.forename: G V
authors.initials: GV
authors.lastname: Adamova
authors.forename: M N
authors.initials: MN
authors.lastname: Plotnikova
mesh_terms: D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D000992:Antitoxins / Q000097:blood; D002772:Cholera Toxin / Q000037:antagonists & inhibitors; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006801:Humans; D007277:Injections, Jet; D008297:Male; D008875:Middle Aged; D019081:O Antigens; D013997:Time Factors; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D014734:Vibrio cholerae / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D000992:Antitoxins; D022121:Cholera Vaccines; D019081:O Antigens; D014614:Vaccines, Synthetic; D002772:Cholera Toxin
vernacular_title: Kharakteristika reaktogennosti i immunologicheskoĭ aktivnosti novoĭ kholernoĭ bivalentnoĭ khimicheskoĭ vaktsiny po itogam kontroliruemykh ispytaniĭ.