title: Identity between the novel integrin beta 7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine.
abstract: A cDNA clone encoding the N-terminal sequence of the murine integrin beta 7 subunit, a novel member of the leukocyte cell adhesion molecule subset (Leu-CAM), has been isolated. An N-terminal region of 13 contiguous amino acids deduced from the cDNA shows complete identity with the N-terminus of the 120 kDa subunit of the M290 antigen, a surface molecule found highly expressed on mouse intestinal intraepithelial lymphocytes (IEL). This unexpected result focuses two previously unconnected areas of research and suggests that integrins may have a special role to play in the defence of the gut mucosa.
authors.affiliation: Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand.
authors.forename: Q
authors.initials: Q
authors.lastname: Yuan
authors.forename: W M
authors.initials: WM
authors.lastname: Jiang
authors.forename: D
authors.initials: D
authors.lastname: Hollander
authors.forename: E
authors.initials: E
authors.lastname: Leung
authors.forename: J D
authors.initials: JD
authors.lastname: Watson
authors.forename: G W
authors.initials: GW
authors.lastname: Krissansen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D015152:Blotting, Northern; D004247:DNA / Q000235:genetics; D004848:Epithelium / Q000276:immunology; D015723:Gene Library; D006801:Humans; D016023:Integrins / Q000235:genetics*; D007413:Intestinal Mucosa / Q000276:immunology*; D007421:Intestine, Small / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D046911:Macromolecular Substances; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
chemical_list: D000954:Antigens, Surface; D016023:Integrins; D046911:Macromolecular Substances; D012313:RNA; D004247:DNA