Voltage-sensitive Na+ channels: motifs, modes and modulation.
Much recent progress has been made in understanding the structural organization and functional properties of voltage-dependent Na+ channels, in particular in the areas of activation, ion conductance, and inactivation. At the same time, however, electrophysiological studies have revealed new, more complex functional properties in the form of at least two gating modes and the existence of as yet unidentified modulatory factors.
Stephan
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Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Agnew
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D000200:Action Potentials; D000818:Animals; D001665:Binding Sites; D004247:DNA / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics; D004524:Eels / Q000235:genetics; D005796:Genes; D006031:Glycosylation; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D008322:Mammals / Q000235:genetics; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D009498:Neurotoxins / Q000378:metabolism; D009865:Oocytes; D009928:Organ Specificity; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D012313:RNA / Q000235:genetics; D018075:RNA, Complementary; D011994:Recombinant Proteins / Q000378:metabolism; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000235:genetics / Q000502:physiology*; D014982:Xenopus laevis
D009498:Neurotoxins; D018075:RNA, Complementary; D011994:Recombinant Proteins; D015222:Sodium Channels; D012313:RNA; D004247:DNA; D012964:Sodium