Chromosome assignments of the genes for glucocorticoid receptor, myelin basic protein, leukocyte common antigen, and TRPM2 in the rat.
We have utilized rat-mouse somatic cell hybrids to make chromosomal assignments for the glucocorticoid receptor (GR), myelin basic protein (MBP), leukocyte common antigen (LCA), and testosterone-repressed prostate message-2 (TRPM2) genes in the rat. The genes for GR and MBP both map on chromosome 18 of the rat, which corresponds to the mapping of both genes on chromosome 18 of the mouse. The gene for LCA maps on chromosome 13, which is where C4b-binding protein beta-chain (C4BPB), coagulation factor V (F5), and renin have previously been assigned. This linkage group appears to be homologous to a substantial portion of mouse chromosome 1 and human chromosome 1q. Finally, the TRPM2 gene has been assigned to rat chromosome 15.
Goldner-Sauvé
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A
Department of Human Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104.
Szpirer
C
C
Szpirer
J
J
Levan
G
G
Gasser
D L
DL
D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D015139:Blotting, Southern; D002874:Chromosome Mapping; D051152:Clusterin; D015342:DNA Probes; D006023:Glycoproteins / Q000235:genetics*; D006649:Histocompatibility Antigens / Q000235:genetics*; D006822:Hybrid Cells; D017493:Leukocyte Common Antigens; D008297:Male; D051379:Mice; D018832:Molecular Chaperones; D004676:Myelin Basic Protein / Q000235:genetics*; D011467:Prostate / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats / Q000235:genetics*; D011965:Receptors, Glucocorticoid / Q000235:genetics*
D015703:Antigens, CD; C495243:Clu protein, mouse; D051152:Clusterin; D015342:DNA Probes; D006023:Glycoproteins; D006649:Histocompatibility Antigens; D018832:Molecular Chaperones; D004676:Myelin Basic Protein; D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D017493:Leukocyte Common Antigens