Characteristics of deoxycholic acid-induced histamine release from mast cells of guinea-pig rectocolonic mucosa and rat peritoneal cavity.
Deoxycholic acid (DA) caused a dose-related release of histamine (HR) from mast cells of rat peritoneum (RPMC) and mucosal cells of guinea pig rectocolon (RCMC). In both cell populations, DA-induced HR was: (1) accompared by a parallel release of lactate dehydrogenase (LDH), (2) not affected by metabolic inhibitors, (3) dependent on time of incubation, temperature and pH, and affected by Ca++ concentration in RPMC but not in RCMC. DA-induced HR from RCMC may be involved in certain functional disorders of the colon.
Peh
K H
KH
Department of Pharmacology, University College London, UK.
Wan
B Y
BY
Assem
E S
ES
D000818:Animals; D003106:Colon / Q000166:cytology; D003840:Deoxycholic Acid / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000166:cytology*; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D010529:Peritoneal Cavity / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000166:cytology; D013696:Temperature
D003840:Deoxycholic Acid; D007770:L-Lactate Dehydrogenase