[The modulation of the interferon system by gamma-globulin preparations].
Preparations of specific and commercial gamma-globulin against hepatitis A virus caused a marked inhibition of alpha- and gamma-links of the IF system 7 days after administration. In 80% of the subjects given commercial gamma-globulin 14 days after administration the above values returned to those observed before administration of the preparations. The recovery of the leukocyte capacity for alpha-IF production after administration of specific gamma-globulin was observed only in 50% of the subjects examined, while inhibition of the gamma-link of IF system persisted for 14 days (50%) or showed a poor trend to restoration not reaching the initial levels.
Grigorian
S S
SS
Semenenko
T A
TA
Katkov
A I
AI
Ershov
F I
FI
D000276:Adjuvants, Immunologic; D000293:Adolescent; D000328:Adult; D000918:Antibody Specificity; D006508:Hepatitis Antibodies / Q000032:analysis; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000097:blood / Q000187:drug effects*; D007371:Interferon-gamma / Q000097:blood / Q000187:drug effects*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D005719:gamma-Globulins / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D006508:Hepatitis Antibodies; D007370:Interferon Type I; D005719:gamma-Globulins; D007371:Interferon-gamma
Moduliatsiia sistemy interferona preparatami gamma-globulinov.