title: Haemodynamic evidence for per-operative cardiac stress during transurethral prostatectomy. Preliminary communication.
abstract: Haemodynamic changes were measured during routine transurethral prostatectomy (TURP). The heart rate and stroke volume fell progressively over the first 30 min of surgery, resulting in a steady reduction in cardiac output. There was a significant increase in left ventricular afterload from commencement of the procedure. These findings demonstrate that haemodynamic responses, which are not detectable using conventional methods of monitoring, occur during TURP. Increased left ventricular afterload indicates increased myocardial work and oxygen demand which could result in myocardial ischaemia. This may contribute to the increased cardiovascular morbidity and mortality which have been reported to occur after TURP. The possible underlying mechanisms are discussed.
authors.affiliation: Department of Urology, Middlesex Hospital, London.
authors.forename: J W
authors.initials: JW
authors.lastname: Evans
authors.forename: M
authors.initials: M
authors.lastname: Singer
authors.forename: C R
authors.initials: CR
authors.lastname: Chapple
authors.forename: N
authors.initials: N
authors.lastname: Macartney
authors.forename: S W
authors.initials: SW
authors.lastname: Coppinger
authors.forename: E J
authors.initials: EJ
authors.lastname: Milroy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000503:physiopathology / Q000601:surgery*; D013318:Stroke Volume; D014655:Vascular Resistance