title: n-3 fatty acids and acute-phase proteins.
abstract: The aim of this study was to determine the effects of n-3 fatty acids on acute-phase proteins and response. Healthy male volunteers were submitted to standard bicycle ergometry once without supplementation and a second time after 3-weeks supplementation with highly purified n-3 fatty acids (1.75 g eicosapentaenoic acid and 1.05 g docosahexaenoic acid per day). Acute-phase proteins (immunoglobulin M, complement C4, haptoglobin, C-reactive protein, alpha 2-macroglobulin, coerulopasmin, fibrinogen, alpha 1-glycoprotein) were measured before, immediately after, 24 and 72 h after exercise. There were significantly lower values of immunoglobulin M (pre-exercise and at 72 h) and alpha 2-macroglobulin (pre-exercise) when cross-sectionally comparing the baseline data with and without n-3 supplementation. Longitudinal comparisons show that the ergometric test induced a discrete acute-phase reaction, which is evident with and without n-3 fatty acids. Yet the kinetics of the response seem to be altered by n-3 supplementation. The relative increase of most acute-phase proteins is numerically larger and the rise persists longer, which is particularly evident for fibrinogen and alpha 1-glycoprotein. The findings suggest that n-3 fatty acids lower acute-phase proteins at baseline and alter the pattern of change following acute exercise.
authors.affiliation: Department of Physical Medicine, LM University, Munich.
authors.forename: E
authors.initials: E
authors.lastname: Ernst
authors.forename: T
authors.initials: T
authors.lastname: Saradeth
authors.forename: G
authors.initials: G
authors.lastname: Achhammer
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000097:blood / Q000503:physiopathology; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D015444:Exercise / Q000502:physiology; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology; D006801:Humans; D008297:Male
chemical_list: D000209:Acute-Phase Proteins; D015525:Fatty Acids, Omega-3; D005395:Fish Oils