Effect of bacterial endotoxin on plasma concentration of haptoglobin and fibrinogen in rats treated with metopyrone.
During the acute phase of the inflammatory process there is a characteristic increase in some plasma proteins called collectively acute phase reactants (APR) as well as in the levels of corticosteroids. A bacterial endotoxin (LPS) that induces a strong acute phase response, indicated by high levels of fibrinogen and haptoglobin, did not show this effect when administered to rats treated previously with metopyrone, a specific inhibitor of corticosteroid hormone synthesis. These results suggest that adequate levels of these hormones are important for the production of acute phase reactants.
Silveira
V L
VL
Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.
Limãos
E A
EA
D000209:Acute-Phase Proteins / Q000096:biosynthesis; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000096:biosynthesis*; D006242:Haptoglobins / Q000096:biosynthesis*; D008297:Male; D008797:Metyrapone / Q000494:pharmacology*; D051381:Rats
D000209:Acute-Phase Proteins; D004731:Endotoxins; D006242:Haptoglobins; D003907:Dexamethasone; D005340:Fibrinogen; D003345:Corticosterone; D008797:Metyrapone