Superior cervical ganglionectomy in monkeys: surgical technique.
Seven cynomolgus monkeys underwent a histologically confirmed left superior cervical ganglionectomy (SCGx). Unilateral ocular sympathetic denervation persisting for at least 2 yr was confirmed by ipsilateral ptosis, miosis, supersensitivity of pupillary dilation to topical phenylephrine, and profound pupillary hyporesponsiveness to topical hydroxyamphetamine. Intraocular pressure 8-9 and 23-27 months postoperatively were identical in the denervated and contralateral control eyes. This model should facilitate studies of aqueous humor physiology and pharmacology.
Robinson
J C
JC
Department of Ophthalmology, University of Wisconsin School of Medicine, Madison 53792.
Kaufman
P L
PL
D000287:Administration, Topical; D000818:Animals; D005260:Female; D005728:Ganglia, Sympathetic / Q000473:pathology / Q000601:surgery*; D015171:Ganglionectomy / Q000379:methods*; D007429:Intraocular Pressure; D008252:Macaca fascicularis; D010656:Phenylephrine / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects; D010136:p-Hydroxyamphetamine / Q000494:pharmacology
D010656:Phenylephrine; D010136:p-Hydroxyamphetamine