Independent effects of protein and energy deficiency on acute-phase protein response in rats.
The effect of restricting either protein intake alone or all dietary constituents on the acute-phase protein response was assessed during a 3-wk period after a standardized "injury" (i.e., subcutaneous injection of turpentine 0.5 ml/kg body wt) to rats. Sequential measurements were made of the circulating concentrations of alpha 2-macroglobulin (alpha 2-M), albumin, and total protein. Results were compared with those obtained from normally fed rats that were also injected with turpentine and with saline-injected rats (controls) receiving each dietary regimen. Turpentine-treated rats showed a decrease in albumin concentration by approximately 10 g/L within 2-4 days. In the protein-deficient rats, recovery to preinjection levels had not occurred by 3 wk, but in the other groups, it was complete by 7-9 days. The protein-deficient animals also showed an attenuated response in alpha 2-M and total protein and delay in their recovery toward normal. Maximal alpha 2-M and total-protein responses in this group of animals was only 44 and 39%, respectively, of those found in the control group. We conclude that protein deficiency attenuates the magnitude and alters the time profile of the positive (alpha 2-M and total protein) and negative (albumin) acute-phase protein responses to injury, independent of the severity of the stimulus.
Jennings
G
G
Dunn Nutrition Laboratory, Cambridge, United Kingdom.
Elia
M
M
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000097:blood* / Q000139:chemically induced; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight; D004435:Eating; D002149:Energy Intake; D005508:Food Deprivation; D008297:Male; D011488:Protein Deficiency / Q000097:blood*; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D014425:Turpentine; D000511:alpha-Macroglobulins / Q000378:metabolism
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D012709:Serum Albumin; D000511:alpha-Macroglobulins; D014425:Turpentine