title: Is the beneficial effect of sulfasalazine due to inhibition of synovial neovascularization?
abstract: Angiogenesis is fundamental to support the continued synovial proliferation observed in rheumatoid arthritis. We investigated the effects of sulfasalazine and its metabolites on endothelial cell proliferation, a prerequisite to angiogenesis. At concentrations achieved in vivo sulfapyridine inhibited basal and endothelial cell growth factor stimulated endothelial cell proliferation. Sulfasalazine and 5 amino salicylic acid had no effect.
authors.affiliation: Centre for Rheumatic Diseases, University Department of Medicine, Glasgow Royal Infirmary, Scotland, UK.
authors.forename: R
authors.initials: R
authors.lastname: Madhok
authors.forename: E
authors.initials: E
authors.lastname: Wijelath
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Watson
authors.forename: R D
authors.initials: RD
authors.lastname: Sturrock
authors.forename: H A
authors.initials: HA
authors.lastname: Capell
mesh_terms: D000636:Aminosalicylic Acids / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D019804:Mesalamine; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects; D009389:Neovascularization, Pathologic / Q000473:pathology; D012460:Sulfasalazine / Q000494:pharmacology* / Q000627:therapeutic use; D013583:Synovial Membrane / Q000098:blood supply* / Q000166:cytology / Q000187:drug effects
chemical_list: D000636:Aminosalicylic Acids; D012460:Sulfasalazine; D019804:Mesalamine