title: [Resistance of isolated cells from squamous cell carcinomas of the oral cavity to cytotoxic drugs].
abstract: Human tumor cells from 22 patients with squamous cell carcinomas of the oral cavity were cultivated in vitro and then subjected to sensitivity tests to cytotoxic drugs such as methotrexate, 5-fluorouracil, cisplatin and bleomycin. Tumor cell proliferation showed drug-specific reaction patterns and time-dose-dependent variations. While the effect of methotrexate on cell proliferation was insignificant, 5-fluorouracil caused a growth suppression of 50%. Cisplatin and bleomycin suppressed cell growth by more than 90%.
authors.affiliation: Klinikum der Christian-Albrechts-Universität zu Kiel.
authors.forename: J E
authors.initials: JE
authors.lastname: Eickbohm
authors.forename: T
authors.initials: T
authors.lastname: Görögh
authors.forename: B
authors.initials: B
authors.lastname: Lippert
authors.forename: R
authors.initials: R
authors.lastname: Ewers
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001761:Bleomycin / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002455:Cell Division / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005472:Fluorouracil / Q000494:pharmacology; D006801:Humans; D008727:Methotrexate / Q000494:pharmacology; D009062:Mouth Neoplasms / Q000188:drug therapy*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D001761:Bleomycin; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Zytostatikaresistenz isolierter Plattenepithelkarzinomzellen aus Mundhöhlentumoren.