[The action of tomicide on macromolecular synthesis in bacterial cells].
The study of the rate of incorporation of labeled precursors for nucleic acids and protein into Staphylococcus aureus 209 P cell fraction, insoluble in trichloroacetic acid, has revealed that in the presence of tomicide in the medium in a dose of 1 MCI (600 micrograms/ml) the synthesis of DNA in inhibited rapidly and almost completely (by 90%). The inhibition of the rate of incorporation of 3H-thymidine into the cells of staphylococcal culture by tomicide directly correlates with the concentration of the preparation within the range 100-600 micrograms/ml, the inhibition of the synthesis of RNA and protein being less pronounced than the inhibition of the synthesis of DNA.
Butova
L G
LG
Blinkova
L P
LP
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001430:Bacteriocins; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D007930:Leucine / Q000187:drug effects / Q000378:metabolism; D046911:Macromolecular Substances; D012329:RNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium; D014529:Uridine / Q000378:metabolism
D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D001430:Bacteriocins; D004269:DNA, Bacterial; D046911:Macromolecular Substances; D012329:RNA, Bacterial; D014316:Tritium; C026129:tomicide; D007930:Leucine; D013936:Thymidine; D014529:Uridine
Deĭstvie tomitsida na sintez makromolekul v bakterial'nykh kletkakh.