title: [Effect of a new 10% hydroxyethyl starch solution HES/270/0.5 on blood coagulation, blood loss and hemodynamics in comparison with 3.5% PPL].
abstract: 20 patients scheduled for total hip replacement were given 1,000 ml of a new preparation of 10% hydroxyethylstarch (HES) (MW 270,000: 0.5) preoperatively. They were compared to a group of 20 patients who received 1,000 ml of 3.5% plasma protein solution (PPS). HES caused a more pronounced hemodilution than PPS. With HES, central venous pressure (CVP) rose significantly higher than with PPS. PTT was significantly prolonged in the HES but not in the PPS group. TT was significantly reduced by HES in comparison to PPS. PT (Quick-value %) and fibrinogen levels showed no difference in both groups. Blood loss and transfusion volume were comparable to HES and PPS until 24 h after the operation. One patient showed generalised flush after HES. This HES preparation is a colloid with volume-expanding properties and appears to be without clinically apparent effects on coagulation (up to a volume of 11).
authors.affiliation: Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin Westfälischen Wilhelms-Universität Münster.
authors.forename: M
authors.initials: M
authors.lastname: Penner
authors.forename: D
authors.initials: D
authors.lastname: Fingerhut
authors.forename: A
authors.initials: A
authors.lastname: Tacke
mesh_terms: D001780:Blood Coagulation Tests; D016063:Blood Loss, Surgical; D001798:Blood Proteins / Q000008:administration & dosage; D001810:Blood Volume / Q000187:drug effects*; D006438:Hemodilution; D006439:Hemodynamics / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects*; D006622:Hip Prosthesis; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage* / Q000009:adverse effects; D010952:Plasma Substitutes / Q000008:administration & dosage* / Q000009:adverse effects; D011183:Postoperative Complications / Q000097:blood*
chemical_list: D001798:Blood Proteins; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes
vernacular_title: Einfluss einer neuen Hydroxyäthylstärkelösung 10% HES/270/0,5 auf Blutgerinnung, Blutverlust und Hämodynamik im Vergleich zu PPL 3,5%.