title: The secretory endometrial protein, placental protein 14, in women with ectopic gestation.
abstract: OBJECTIVE
  To determine the serum level of the secretory endometrial protein, placental protein 14 (PP14) and progesterone (P) in women with ectopic gestation.
  
  
  METHODS
  Blood samples were collected prospectively and preoperatively. Reference range was determined from a prospective population of 98 women with uncomplicated pregnancies and normal outcome.
  
  
  METHODS
  The women were admitted to a university hospital.
  
  
  METHODS
  Fifty-nine women with laparoscopically verified ectopic pregnancy entered the study.
  
  
  METHODS
  At the time of diagnosis PP14 and P were measured.
  
  
  METHODS
  After observing the low serum levels of PP14 and P, a correlation analysis was made and compared with the findings in normally pregnant women.
  
  
  RESULTS
  A significant positive correlation was found between the level of PP14 and P (P less than 0.00002), not found in normal intrauterine pregnancies.
  
  
  CONCLUSIONS
  These findings suggest that the regulation of the PP14 production involves either a control mechanism from the ovary or is mediated by paracrine secretion.
authors.affiliation: Department of Obstetrics and Gynaecology, Hvidovre University Hospital, Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Ruge
authors.forename: S
authors.initials: S
authors.lastname: Sørensen
authors.forename: M
authors.initials: M
authors.lastname: Vejtorp
authors.forename: L O
authors.initials: LO
authors.lastname: Vejerslev
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins; D006801:Humans; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood* / Q000378:metabolism; D011271:Pregnancy, Ectopic / Q000097:blood*; D011374:Progesterone / Q000097:blood; D011446:Prospective Studies; D012016:Reference Values
chemical_list: D015415:Biomarkers; D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D011374:Progesterone