title: The acute effect of topical epinephrine on macular blood flow in humans.
abstract: The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated leukocytes on a computer screen to match that of their own entoptically perceived leukocytes before instilling the drug and 2 hr thereafter. An artificial tear solution was instilled into the fellow eye for a control. Epinephrine instillation resulted in a 8% increase in macular leukocyte velocity and presumably blood flow (P less than 0.03, paired student t-test).
authors.affiliation: Department of Ophthalmology, University of Pennsylvania School of Medicine.
authors.forename: F
authors.initials: F
authors.lastname: Robinson
authors.forename: S
authors.initials: S
authors.lastname: Chen
authors.forename: B L
authors.initials: BL
authors.lastname: Petrig
authors.forename: J E
authors.initials: JE
authors.lastname: Grunwald
authors.forename: C E
authors.initials: CE
authors.lastname: Riva
mesh_terms: D000287:Administration, Topical; D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008266:Macula Lutea / Q000098:blood supply* / Q000187:drug effects; D008875:Middle Aged; D011897:Random Allocation
chemical_list: D004837:Epinephrine