[Pancreatitis associated with 5-aminosalicylic acid].
Acute pancreatitis with severe belt-like upper abdominal pain developed within 1-4 weeks of starting medication in three patients (29-year-old man with ulcerative colitis; 43-year-old woman and 22-year-old woman with Crohn's disease) treated, for the first time, with 5-aminosalicylic acid (mesalazine), 500 mg three times daily. Concentrations of lipase initially were 545, 1182 and 3000 U/l, and of amylase 243, 449 and 129 U/l, respectively. Symptoms receded within a few hours after the drug had been discontinued, enzyme levels returning to normal in the course of the next 2-3 weeks. On repeating the drug in two of the patients, in lower dosage, the pancreatitis recurred within a few days. These observations support the view that 5-aminosalicylic acid can cause acute pancreatitis, perhaps as an allergic reaction.
Eckardt
V F
VF
Gastroenterologische Fachpraxis Wiesbaden, Universität Mainz.
Kanzler
G
G
Rieder
H
H
Ewe
K
K
D000208:Acute Disease; D000328:Adult; D000636:Aminosalicylic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D000681:Amylases / Q000097:blood; D004796:Clinical Enzyme Tests; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D005260:Female; D006801:Humans; D008049:Lipase / Q000097:blood; D008297:Male; D019804:Mesalamine; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis
D000636:Aminosalicylic Acids; D019804:Mesalamine; D008049:Lipase; D000681:Amylases
5-Aminosalicylsäure-assoziierte Pankreatitis.