[Clinical, bacteriological and cost-saving effects of antibiotic prophylaxis in craniotomy].
Objective of the study. To investigate the effect of antibiotic prophylaxis on the incidence of infections, on the bacterial flora of wounds and on the health-care costs. A retrospective study disclosed an incidence of infection of 8.1% in patients who underwent craniotomy. Methods. Double-blind, placebo-controlled study of the effects of cloxacillin (4 x 1 gr intravenously during 24 h, perioperatively) in 310 patients who had to undergo a craniotomy. Results. In the cloxacillin group significantly fewer infections occurred than in the placebo group, 6 infections in 156 and 20 infections in 154, respectively. In the cloxacillin group significantly fewer samples contained micro-organisms than in the placebo group. Cloxacillin prophylaxis reduces the cost of patient care by about 20%. Conclusion. Cloxacillin prophylaxis in craniotomy cases reduces the percentage of infections, the percentage of positive cultures of the wound, and the costs of patient care.
van Ek
B
B
Afd. Infectieziekten, Academisch Ziekenhuis, Leiden.
Dijkmans
B A
BA
van Dulken
H
H
Mouton
R P
RP
van Furth
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D001419:Bacteria / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D003023:Cloxacillin / Q000627:therapeutic use*; D003363:Cost Control; D003399:Craniotomy / Q000009:adverse effects / Q000191:economics; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011446:Prospective Studies; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*
D003023:Cloxacillin
Klinische, bacteriologische en kostenbesparende effecten van antibiotische profylaxe bij craniotomie.