title: Effect of hippurate on glucose utilization in rat kidney cortex slices.
abstract: Hippurate action on glucose utilization was evaluated in rat kidney cortex slices. Studies have shown the following. (1) Hippurate inhibits markedly basal as well as insulin-stimulated glucose utilization and basal gluconeogenesis. (2) Ca deficiency and specific Ca channel blockers diltiazem and isradipine abolish the hippurate inhibition of glucose utilization. (3) K+ channel blockers, i.e. the increased K+ concentration in incubation medium, procaine and sulfonylurea drugs also abolish the hippurate inhibition of glucose utilization. It is concluded that hippurate and benzoate operate through the ATP-dependent K+ channel.
authors.affiliation: Medical Bionics Research Institute, Bratislava, Czechoslovakia.
authors.forename: V
authors.initials: V
authors.lastname: Spustová
authors.forename: R
authors.initials: R
authors.lastname: Dzúrik
mesh_terms: D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D019817:Benzoic Acid; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D004110:Diltiazem / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005943:Gluconeogenesis / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006626:Hippurates / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D017275:Isradipine; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001565:Benzoates; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D006626:Hippurates; D007328:Insulin; D011725:Pyridines; D019817:Benzoic Acid; D004110:Diltiazem; D005947:Glucose; C030514:hippuric acid; D017275:Isradipine