Lindane induced changes in morphology and lipids profile of testes in rats.
Intraperitoneal treatment of adult male rats with lindane at dosages of 4 and 8 mg/kg over a period of 45 days caused retardation in body and testicular growth. Testicular degeneration was conspicuous over a period of 45 days in both dosages of lindane. After treatment with lindane, histochemical and biochemical studies revealed the accumulation of testicular lipid components, i.e. total lipids, triglycerides and cholesterol along with fatty degeneration in testicular tissues. Moreover, the loss of male accessory organ weight indicated androgen deficiency in treated rats.
Chowdhury
A R
AR
National Institute of Occupational Health (I.C.M.R.), Meghani Nagar, Ahmedabad, India.
Gautam
A K
AK
Bhatnagar
V K
VK
D000818:Animals; D004305:Dose-Response Relationship, Drug; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D050356:Lipid Metabolism; D008297:Male; D009929:Organ Size; D051381:Rats; D013737:Testis / Q000002:abnormalities / Q000187:drug effects* / Q000648:ultrastructure
D001556:Hexachlorocyclohexane