Examination of the roles of selenium in the Kaschin-Beck disease. Cartilage cell test and model studies.
The Kaschin-Beck Disease, an endemic disease in China, occurs in low-selenium areas. Using human embryonic cartilage cell as a system, the effect of selenite and another etiological factors, such as, organic matters in water, and grain from disease regions, were studied. It was shown that Se(IV), as well as superoxide dismutase, could prevent the cells from damage by organic matters, and increase the activity of GSHpx and decrease the production of lipid peroxide. A model test of adrenalin autooxidation was carried out, and it was found that the oxy-radical can be eliminated by Se(IV). Thus, it was assumed, that selenium was a protective factor and free radical scavenger for Kaschin-Beck Disease.
Peng
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A
Research Center for Eco-Environmental Sciences, Academia Sinica, Beijing, P. R. China.
Yang
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CL
D001578:Benzopyrans / Q000494:pharmacology; D002356:Cartilage / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002681:China; D004622:Embryo, Mammalian; D004837:Epinephrine / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D012643:Selenium / Q000172:deficiency* / Q000378:metabolism / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology
D001578:Benzopyrans; D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; C005023:fulvic acid; D004837:Epinephrine