title: [Monoclonal antibodies against determinants on human MHC class II antigens].
abstract: Monoclonal antibodies against different non-polymorphic determinants of HLA class II antigens are described. The epitopes are present on HLA-DR and HLA-DQ gene products as detected by monoclonal antibody BL-Ia/l, and at HLA-DR and HLA-DP gene products which are recognized by monoclonal antibody BL-Ia/4. Another epitope recognized by the monoclonal antibody BL-Ia/DQ is only found on DQ molecules. The monoclonal antibodies BL-Ia/1, BL-Ia/4, and BL-Ia/5 are directed against the beta-subunit of 29 kDa/35 kDa class II heterodimer molecules. The recognized epitopes are shown to be not dependent on the association of the alpha- and beta-chains.
authors.affiliation: Bereich Tierphysiologie und Immunbiologie, Karl-Marx-Universität Leipzig.
authors.forename: W
authors.initials: W
authors.lastname: Eichler
authors.forename: M
authors.initials: M
authors.lastname: Seifert
authors.forename: H
authors.initials: H
authors.lastname: Fiebig
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D015180:Electrophoresis, Gel, Two-Dimensional; D000939:Epitopes; D005434:Flow Cytometry; D006681:HLA-D Antigens / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007526:Isoelectric Point; D008285:Major Histocompatibility Complex; D008970:Molecular Weight; D011233:Precipitin Tests
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D006681:HLA-D Antigens
vernacular_title: Monoklonale Antikörper gegen Determinanten humaner MHC-Klasse II-Antigene.