Isochromosome (6p) in Waldenstrom's macroglobulinemia.
Cytogenetic data on two cases of previously treated Waldenstrom's macroglobulinemia (WM) are presented. An i(6p) was identified in 60 and 56% of bone marrow (BM) metaphases from each patient, respectively. In both cases, i(6p) occurred as part of a complex karyotype but was also observed as the sole abnormality in a proportion of metaphases. The literature on the cytogenetics of WM and the relevance of i(6p) is discussed.
White
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Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff.
Clark
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Jacobs
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D002869:Chromosome Aberrations; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics*