title: [Localization and extent of tissue damage caused by extracorporeal lithotripsy (ESWL)].
abstract: Extracorporeal shock wave lithotripsy (ESWL) causes proteinuria. In our study we investigated the protein fractions and the electrolyte composition of the urine in patients who had been treated with ESWL. The aim was to obtain information on the degree and the localisation of the glomerular, tubular or vascular destruction caused by ESWL in humans. A total of 34 patients with stones had been treated with ESWL. As parameters we used: urine output, creatinine clearance, total protein, albumin, immunoglobulin G, N-acetyl-beta-D-glucosaminidase (beta-NAG), alpha-1-microglobulin, the fractional excretion of Na+ and apolipoprotein-A-1. After ESWL treatment proteinuria and albuminuria are found. Our parameters show no deterioration of the glomerula or the tubulus. The increase in apolipoprotein-A-1, a postglomerular parameter, however, is interpreted as a manifestation of vascular destruction after ESWL; this is normally temporary, leaving no permanent damage.
authors.affiliation: Urologische Klinik und Poliklinik, Georg-August-Universität Göttingen.
authors.forename: M
authors.initials: M
authors.lastname: Kallerhoff
authors.forename: K
authors.initials: K
authors.lastname: Müller-Siegel
authors.forename: R
authors.initials: R
authors.lastname: Verwiebe
authors.forename: M H
authors.initials: MH
authors.lastname: Weber
authors.forename: K
authors.initials: K
authors.lastname: Wassmann
authors.forename: M
authors.initials: M
authors.lastname: Blech
authors.forename: F
authors.initials: F
authors.lastname: Scheler
authors.forename: R H
authors.initials: RH
authors.lastname: Ringert
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000419:Albuminuria / Q000201:enzymology / Q000209:etiology*; D000510:Alpha-Globulins / Q000652:urine; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D007669:Kidney Calculi / Q000201:enzymology / Q000628:therapy*; D007677:Kidney Function Tests; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000201:enzymology / Q000209:etiology*; D012307:Risk Factors; D012964:Sodium / Q000652:urine; D014563:Urodynamics / Q000502:physiology
chemical_list: D000510:Alpha-Globulins; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D007074:Immunoglobulin G; C016001:alpha-1-microglobulin; D012964:Sodium; D003404:Creatinine; D000118:Acetylglucosaminidase
vernacular_title: Lokalisation und Ausmass einer Gewebeschädigung durch die extrakorporale Lithotrypsie (ESWL).