Changes in the carbohydrate metabolism in the selected tissues of Mus booduga gray after BHC treatment.
Adult mice, Mus booduga were fed orally with bennzenehexachloride (BHC) at a dose of 50 mg/kg body weight every day for 1, 5 and 15 days. Significant decrease in the pyruvate content was observed at all periods of treatment. In support of this increase in lactate content and lactate dehydrogenase (LDH) activity was noticed in all the three tissues. Enzymes of TCA cycle namely isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) were inhibited suggesting abnormality in mitochondrial oxidative metabolism as a consequence of BHC toxicity.
Philip
G H
GH
Department of Zoology, Sri Venkateswara University, Tirupati, India.
Reddy
P M
PM
Ramamurthi
R
R
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007521:Isocitrate Dehydrogenase / Q000037:antagonists & inhibitors; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008291:Malate Dehydrogenase / Q000037:antagonists & inhibitors; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors
D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D001556:Hexachlorocyclohexane; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D013385:Succinate Dehydrogenase