On the superposition of currents from ion channels.
We derive a number of statistical properties of the superposition of several independent channels contributing to a patch-clamp recording. Failure of these properties indicates dependence of the channels and may suggest the nature of interactions. We show how properties such as dwell-time distributions of the individual channels may be determined from those of the superposition in the case that the channels are independent.
Fredkin
D R
DR
Department of Physics, University of California, San Diego, La Jolla 92093.
Rice
J A
JA
D000818:Animals; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D008954:Models, Biological; D011336:Probability
D007473:Ion Channels