title: Neutralizing antibody to Mengo virus, induced by synthetic peptides.
abstract: A peptide from the carboxyl-terminal region of the Mengo virus capsid protein VP1, representing residues 259 to 277, can induce serum neutralizing (SN) antibodies in both the mouse and guinea-pig. This peptide, termed F164, also induces high levels of protective neutralizing antibodies in mice subsequent to immunization; 87 to 100% of mice are refractory to the effects of an intraperitoneal challenge of 100 LD50 of Mengo virus. The mouse model discussed herein will prove useful for studying the immune response to Mengo virus and evaluating the immunogenicity of individual viral components.
authors.affiliation: Department of Molecular Biology, Research Institute Scripps Clinic, La Jolla, California 92037.
authors.forename: S
authors.initials: S
authors.lastname: Muir
authors.forename: J P
authors.initials: JP
authors.lastname: Weintraub
authors.forename: J
authors.initials: J
authors.lastname: Hogle
authors.forename: J L
authors.initials: JL
authors.lastname: Bittle
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology*; D002213:Capsid / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D006168:Guinea Pigs; D008574:Mengovirus / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D010455:Peptides / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology; D014771:Virion / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000939:Epitopes; D010455:Peptides; D014614:Vaccines, Synthetic; D014765:Viral Vaccines