title: Histochemistry and electron-microscopic observation in two cases of granular dystrophy of the cornea.
abstract: We report on 2 cases of granular dystrophy (Groenouw type I). We studied the nature and the ultrastructure of the typical stromal deposits by means of histochemical methods and of electron-microscopic examination. These deposits did not stain with Alcian blue, periodic acid-Schiff, Mallory, van Gieson, von Kossa or Congo red so that they are not constituted of proteoglycans, collagen, calcium or amyloid. They probably contain a proteic material. At the electron-microscopic level we observed electron-dense material which was made up of filaments immersed into an amorphous matrix.
authors.affiliation: Chair of Physiopathologic Optics, La Sapienza University, Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Leopardi
authors.forename: A
authors.initials: A
authors.lastname: Cucinotta
authors.forename: A
authors.initials: A
authors.lastname: Chetri
authors.forename: R
authors.initials: R
authors.lastname: Appolloni
authors.forename: C
authors.initials: C
authors.lastname: Balacco-Gabrieli
mesh_terms: D000328:Adult; D003317:Corneal Dystrophies, Hereditary / Q000473:pathology*; D003319:Corneal Stroma / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D015948:Keratoplasty, Penetrating; D008854:Microscopy, Electron; D013194:Staining and Labeling