Comparison of the effects of sodium pentosanpolysulfate and unfractionated heparin on venous thrombosis; an experimental study in rats.
Sodium pentosanpolysulfate (Fibrezym) and unfractionated heparin (Liquemin) had significant antithrombotic efficacy in rats. 1 mg/kg body weight (BW) FibrezymR had its maximal effect 2-4 hours after subcutaneous administration; 200 U/kg BW LiqueminR s.c. were most effective 4-6 hours after application. Both drugs caused frequent embolic break-offs of thrombi during the time periods of maximal antithrombotic efficiency.
Kiesel
J
J
Department of Clinical Hemostaseologie and Transfusion Medicin, University Homburg, Germany.
Harbauer
G
G
Wenzel
E
E
Pindur
G
G
Bohnerth
S
S
D000818:Animals; D004617:Embolism; D006493:Heparin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008297:Male; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013924:Thrombophlebitis / Q000188:drug therapy*; D013997:Time Factors
D010426:Pentosan Sulfuric Polyester; D006493:Heparin