Effect of glycyrrhizin on pain and HLA-DR antigen expression on CD8-positive cells in peripheral blood of herpes zoster patients in comparison with other antiviral agents.
Glycyrrhizin (GL) is a saponin widely used as an anti-inflammatory agent. Pain intensity and HLA-DR antigen expression on CD8+ cells were assessed during and after treatment with GL. Other agents such as acyclovir, gamma-globulin and interferon beta were also administered for comparison. Pain resolved most rapidly among those treated with acyclovir followed by those treated with GL. Pain resolution correlated with the regression of HLA-DR+ in CD8+ subpopulations in peripheral blood. GL is suggested to be an alternative or additive antiviral agent to herpes zoster.
Aikawa
Y
Y
Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
Yoshiike
T
T
Ogawa
H
H
D000212:Acyclovir / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D000998:Antiviral Agents / Q000494:pharmacology*; D016827:CD8 Antigens; D005260:Female; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D006684:HLA-DR Antigens / Q000276:immunology*; D006562:Herpes Zoster / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy*; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D005719:gamma-Globulins / Q000494:pharmacology
D000945:Antigens, Differentiation, T-Lymphocyte; D000998:Antiviral Agents; D016827:CD8 Antigens; D006684:HLA-DR Antigens; D007370:Interferon Type I; D005719:gamma-Globulins; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid; D000212:Acyclovir