title: Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure.
abstract: When introduced intranasally, P. cepacia AC1100 (approximately 10(8) CFU/animal) and P. aeruginosa AC869 (approximately 10(3) CFU/animal) were readily cleared from the mouse. However, a approximately 10(7)-CFU dose of AC869 persisted for 14 days. Strain AC869 had a 50% lethal dose of 2.7 x 10(7) CFU. Slight morbidity occurred in animals treated with approximately 10(7) CFU of AC869 or approximately 10(8) CFU of AC1100.
authors.affiliation: Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
authors.forename: S E
authors.initials: SE
authors.lastname: George
authors.forename: M J
authors.initials: MJ
authors.lastname: Kohan
authors.forename: D A
authors.initials: DA
authors.lastname: Whitehouse
authors.forename: J P
authors.initials: JP
authors.lastname: Creason
authors.forename: C Y
authors.initials: CY
authors.lastname: Kawanishi
authors.forename: R L
authors.initials: RL
authors.lastname: Sherwood
authors.forename: L D
authors.initials: LD
authors.lastname: Claxton
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D016956:Burkholderia cepacia / Q000472:pathogenicity*; D003264:Containment of Biohazards; D004783:Environmental Microbiology; D008297:Male; D051379:Mice; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*