Modification of exogenous haemopoietic spleen colony formation in irradiated mice by antisera against mouse thymocytes and mouse brain.
Treatment of donor bone marrow in vitro with both anti-thymocyte serum (ATS) and anti-mouse brain serum (RAMBS) inhibits the formation of haemopoietic spleen colonies in irradiated and reconstituted mice. This activity of the antisera may be completely (ATS) or partly (RAMBS) eliminated by absorption with thymocytes. The effect of the antisera is complement-independent. Most likely it depends on the existence and functionality of phagocytes (macrophages) in the recipients.
Schäffner
H
H
Sektion Biowissenschaften Karl-Marx-Universität Leipzig.
Zimdars
B
B
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D001921:Brain / Q000276:immunology*; D002470:Cell Survival / Q000187:drug effects; D003037:Cobalt Radioisotopes; D003114:Colony-Forming Units Assay; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology / Q000528:radiation effects*; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
D000961:Antilymphocyte Serum; D003037:Cobalt Radioisotopes