The polymerase in its labyrinth: mechanisms and implications of RNA recombination.
The wide variety of RNA viruses, and the diseases associated with them, may result in part from the capacity of RNA genomes to evolve through genetic recombination. Here we address the mechanism of RNA recombination, and ask questions about its prevalence and purpose in nature.
Jarvis
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TC
Department of Molecular, Cellular and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder 80309.
Kirkegaard
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D005075:Biological Evolution; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D014644:Genetic Variation; D008957:Models, Genetic; D012313:RNA; D012328:RNA Viruses / Q000235:genetics*; D011995:Recombination, Genetic; D013698:Templates, Genetic
D012313:RNA; D012321:DNA-Directed RNA Polymerases