In vitro studies of elastin-fibrin biomaterial degradation: preservative effects of protease inhibitors and antibiotics.
The degradability of a new elastin-fibrin material was tested in vitro versus human pancreatic elastase (HPE) and plasmin (PL) activities. It is shown that aprotinine Iniprol, a well-known protease inhibitor and Eglin C, a new potent inhibitor of HPE, especially when used in synergy, efficiently protected the material. A small amount of specific antibiotics was incorporated into the material. The two products will allow the material to be used in digestive surgery with improved safety.
Collet
D
D
INSERM, Unité 306, Université de Bordeaux II, France.
Lefebvre
F
F
Quentin
C
C
Rabaud
M
M
D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D007611:Aprotinin / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002444:Cefuroxime / Q000737:chemistry; D004549:Elastin / Q000737:chemistry*; D005337:Fibrin / Q000737:chemistry*; D005341:Fibrinolysin / Q000737:chemistry; D008422:Materials Testing; D010196:Pancreatic Elastase / Q000737:chemistry; D011093:Polyethylene Terephthalates / Q000737:chemistry; D011098:Polyglactin 910 / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry*; D011506:Proteins; D015842:Serine Proteinase Inhibitors / Q000737:chemistry; D015843:Serpins
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D011480:Protease Inhibitors; D011506:Proteins; D015842:Serine Proteinase Inhibitors; D015843:Serpins; C028656:eglin proteinase inhibitors; D011098:Polyglactin 910; D002244:Carbon; D005337:Fibrin; D004549:Elastin; D007611:Aprotinin; D010196:Pancreatic Elastase; D005341:Fibrinolysin; D002444:Cefuroxime