title: Changes of ionic channel distribution in myelinated nerve fibres from rats with experimental allergic neuritis.
abstract: Voltage clamp experiments were performed in single myelinated nerve fibres of rats with experimental allergic neuritis (EAN). Nerve fibres from diseased animals showed a varying degree of demyelination. In fibres with extensive demyelination large K+ currents were measured. Analysis of the contribution of slow and fast K+ channels revealed that in these fibres the relative contribution of slow K+ channels was about 50% compared to about 25% in fibres acutely demyelinated as previously reported. This indicates that chronic demyelination changes the distinct distribution of ionic channels in the rat node of Ranvier.
authors.affiliation: Physiologisches Institut, Universitätskrankenhaus Eppendorf, Hamburg, F.R.G.
authors.forename: J R
authors.initials: JR
authors.lastname: Schwarz
authors.forename: B J
authors.initials: BJ
authors.lastname: Corrette
authors.forename: K
authors.initials: K
authors.lastname: Mann
authors.forename: H
authors.initials: H
authors.lastname: Wiethölter
mesh_terms: D000818:Animals; D003711:Demyelinating Diseases / Q000503:physiopathology*; D004553:Electric Conductivity; D005260:Female; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D009444:Neuritis, Autoimmune, Experimental / Q000503:physiopathology*; D015221:Potassium Channels / Q000502:physiology*; D011901:Ranvier's Nodes / Q000502:physiology*; D051381:Rats; D011917:Rats, Inbred Lew; D012016:Reference Values; D012044:Regression Analysis; D015222:Sodium Channels / Q000502:physiology
chemical_list: D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels