Susceptibility to proteolipid apoprotein and its encephalitogenic determinants in mice.
We investigated in mice strain differences in induction of experimental allergic encephalomyelitis by proteolipid apoprotein and studied encephalitogenic determinants. SJL/J, C3H/He, CBA/J and A/J mice were high responders, BALB/c and AKR/J mice were moderately susceptible, and DBA/2, B6 and congenic strains of B10 background were low responders. Synthetic peptide 136-150 was encephalitogenic for SJL/J mice, and 215-232 was encephalitogenic for C3H/He mice. These encephalitogenic derterminants are present in the extracellular portion of proteolipid apoprotein in myelin.
Endoh
M
M
Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan.
Kunishita
T
T
Nihei
J
J
Nishizawa
M
M
Tabira
T
T
D000818:Animals; D001059:Apoproteins / Q000276:immunology*; D002417:Cattle; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology*; D000939:Epitopes / Q000032:analysis*; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D051379:Mice; D004676:Myelin Basic Protein / Q000276:immunology*; D009185:Myelin Proteins / Q000276:immunology*; D018991:Myelin Proteolipid Protein; D010446:Peptide Fragments / Q000276:immunology; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D001059:Apoproteins; D000939:Epitopes; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D010446:Peptide Fragments