title: Coagulase-negative staphylococcus in chronic prostatitis.
abstract: Three male patients with a clinical history of prostatitis with coagulase-negative staphylococci localized to the expressed prostatic secretion and who did not respond to antibiotics were studied intensively 4 weeks after cessation of therapy with repeat culture of the prostatic fluid, as well as with culture, and histological and ultrastructural examination of multiple prostatic biopsies. Coagulase-negative staphylococci were cultured in the biopsied prostatic tissue, and gram-positive staphylococci were identified in sparse and focal microcolonies adherent to the prostatic ductal walls. Coagulase-negative staphylococci may be implicated in the pathogenesis of chronic bacterial prostatitis.
authors.affiliation: Department of Urology, Queen's University, Kingston General Hospital, Ontario, Canada.
authors.forename: J C
authors.initials: JC
authors.lastname: Nickel
authors.forename: J W
authors.initials: JW
authors.lastname: Costerton
mesh_terms: D000328:Adult; D001706:Biopsy; D002908:Chronic Disease; D003030:Coagulase / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D011467:Prostate / Q000382:microbiology / Q000648:ultrastructure; D011472:Prostatitis / Q000382:microbiology* / Q000473:pathology; D013203:Staphylococcal Infections / Q000473:pathology; D013210:Staphylococcus / Q000201:enzymology / Q000302:isolation & purification* / Q000648:ultrastructure
chemical_list: D003030:Coagulase