title: [A case of cranial and intracranial metastasis from testicular seminoma].
abstract: The case presented is of a 44-year-old man with skull and intracranial metastasis of seminoma. He was operated on for a testicular tumor at 41 years of age. Pathologically, it was pure seminoma. Coronal CT scan showed tumor invasion of the subcutaneous vault, and of the epidural and intraparenchymal region of the right parietal region. We treated him with a combination of surgical excision, radiation and PVB chemotherapy. He was neurologically disease-free for ten months after being discharged. However, he then succumbed to liver metastasis of seminoma. Seminoma mainly metastasizes via the lymph stream. CNS metastasis of seminoma is only 0.7% in Japan. We would like to stress that prophylactic chemotherapy would be essential even after patients get remission from CNS metastasis of seminoma.
authors.affiliation: Nagoya City University, Department of Neurosurgery.
authors.forename: K
authors.initials: K
authors.lastname: Kamiya
authors.forename: N
authors.initials: N
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Nagai
authors.forename: I
authors.initials: I
authors.lastname: Misawa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004407:Dysgerminoma / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D006801:Humans; D008297:Male; D012888:Skull Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D013736:Testicular Neoplasms / Q000473:pathology*; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin