title: Induction of anti-idiotypic T cells through a network mechanism.
abstract: BALB/c mouse T cells that recognized the idiotype expressed on M104E(mu, lambda 1) were induced by immunization with Dextran B-1355. T cells derived from mice immunized with 1 mg of Dextran B-1355 showed a marked proliferative response against M104E, whereas T cells from mice immunized with Ficoll or smaller amounts of Dextran B-1355 did not. BCL1Id, which had an identical isotype, did not induce proliferation of T cells. The T cell proliferative response against the idiotype on M104E required macrophages as antigen-presenting cells. The proliferative response was inhibited when antigen-presenting cells were treated with NH4Cl or chloroquine, which are antigen-processing inhibitors. These results indicate that anti-idiotypic T cells which recognized processed idiotopes could be induced physiologically through a network mechanism.
authors.affiliation: Third Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Masaki
authors.forename: C
authors.initials: C
authors.lastname: Shirakawa
authors.forename: M
authors.initials: M
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Morita
authors.forename: A
authors.initials: A
authors.lastname: Koyama
authors.forename: F
authors.initials: F
authors.lastname: Horiuchi
authors.forename: H
authors.initials: H
authors.lastname: Hamazaki
authors.forename: T
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: K
authors.initials: K
authors.lastname: Irimajiri
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D003911:Dextrans / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D005260:Female; D007111:Immunity, Cellular; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology*; D014407:Tumor Cells, Cultured
chemical_list: D003911:Dextrans; D000939:Epitopes; D007130:Immunoglobulin Idiotypes