Aminoacyl-tRNA synthetases and DNA replication. Molecular mimicry between RNAII and tRNA(Lys).
Recent data pertaining to different research areas, aminoacyl-tRNA synthetases and replication of ColE1 plasmids, have provided mutually attractive prospects. The gene encoding Escherichia coli lysyl-tRNA synthetase was first isolated as a host suppressor mutation that restores replication of a mutant Co1E1 replicon. Comparison of RNAII and tRNA(Lys) suggests that lysyl-tRNA synthetase is involved in the formation of the displacement loop required for ColE1 plasmids replication and provides major identity elements of tRNA(Lys).
Mirande
M
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Laboratoire d'Enzymologie, Centre National de la Recherche Scientifique, Gif-sur-Yvette, France.
D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism*; D001483:Base Sequence; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D009154:Mutation; D010957:Plasmids; D012313:RNA / Q000235:genetics*; D012357:RNA, Transfer, Lys / Q000235:genetics*
C034477:RNA primers; D012357:RNA, Transfer, Lys; D012313:RNA; D000604:Amino Acyl-tRNA Synthetases