[The role of histamine in neurogenic inflammations of the mouth mucosa in rats].
The effect mechanism of neurogen inflammation incited by local capsaicin irritation was examined by the authors in the oral soft tissue of rats subsequent to antihistamin pretreatment. Furthermore, with the aid of muscarin blocking receptor also the parasympathetic component of the vasodilatation was examined. On basis of their results it was established that the vein-wall-permeability and microcircular changes observed in the course of the neurogen inflammation of the oral soft tissue partly expanded by the histamin through the H1-receptors. The H2-receptors as well as the parasympathetic fibers do not become activated in the process.
Györfi
A
A
Semmelweis Orvostudományi Egyetem, Kórélettani Intézet, Budapest.
Fazekas
A
A
Pósch
E
E
Irmes
F
F
Rosivall
L
L
D000818:Animals; D006632:Histamine / Q000493:pharmacokinetics*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage; D006636:Histamine Release; D008340:Mandibular Nerve / Q000187:drug effects; D009061:Mouth Mucosa / Q000294:innervation; D051381:Rats; D011919:Rats, Inbred Strains; D013280:Stomatitis / Q000209:etiology*
D006634:Histamine H1 Antagonists; D006632:Histamine
A hisztamin szerepe a patkány-szájnyálkahártya neurogén inflammációjában.