Histamine-releasing factors and inhibitory factors.
Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.
Grant
J A
JA
Department of Internal Medicine, University of Texas Medical Branch, Galveston.
Alam
R
R
Lett-Brown
M A
MA
D001491:Basophils / Q000187:drug effects / Q000378:metabolism; D014408:Biomarkers, Tumor; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D016209:Interleukin-8 / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008222:Lymphokines / Q000032:analysis* / Q000037:antagonists & inhibitors; D000090324:Tumor Protein, Translationally-Controlled 1
D014408:Biomarkers, Tumor; D016209:Interleukin-8; D008222:Lymphokines; D000090324:Tumor Protein, Translationally-Controlled 1