The effect of iron deficiency and iron overload on the evolution of Chagas disease produced by three strains of Trypanosoma cruzi in CFW mice.
1. CFW mice were fed either on control diet or on iron-deficient diet. 2. After 5 months the mice were infected with CL, Y or YuYu strain of Trypanosoma cruzi. 3. On the fifth day after the infection, the mice on control diet were divided in three groups: one group remained as controls, two groups were injected either with desferrioxamine or iron-dextran. 4. The severity of the disease was evaluated by parasitemia and mortality. 5. The experimental groups were compared with the infected group fed on the control diet. 6. In mice fed on the iron-deficient diet, the disease was more severe for CL strain and less severe for Y and YuYu strains. 7. Treatment with desferrioxamine produced a less severe disease with YuYu strain and no difference with the other strains. 8. On Treatment with iron-dextran, the disease became more severe with Y and CL strains; no effect was observed with YuYu strain. 9. These findings may be due to intraspecific differences among the strains.
Pedrosa
M L
ML
Departamento de Ciéncias Biológicas, Universidade Federal de Ouro Preto, Brasil.
Silva
M E
ME
Silva
M E
ME
Silva
M E
ME
Nicoli
J R
JR
Vieira
E C
EC
D000818:Animals; D014355:Chagas Disease / Q000378:metabolism* / Q000401:mortality / Q000469:parasitology; D003676:Deferoxamine / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology; D004032:Diet; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000008:administration & dosage / Q000378:metabolism*; D000090463:Iron Deficiencies; D008099:Liver / Q000378:metabolism; D051379:Mice; D013154:Spleen / Q000378:metabolism; D013997:Time Factors; D014349:Trypanosoma cruzi / Q000378:metabolism* / Q000472:pathogenicity
D003911:Dextrans; D006454:Hemoglobins; D007501:Iron; D003676:Deferoxamine