Modulation of immune function by intestinal neuropeptides.
Direct regulatory control of the immune system by the central nervous system has been postulated. In support of this view is a large body of literature describing immunoregulatory activities of neuropeptides isolated from the gastrointestinal tract. In this review we examine the evidence for expression of specific receptors for gut peptides on immune effector cells and further explore the regulatory effects of these peptides on immune function. Peptides to be discussed include substance P, somatostatin, vasoactive intestinal peptide (VIP), the opioid peptides leu and met enkephalin, calcitonin gene related peptide (CGRP), neuropeptide Y, and cholecystokinin (CCK).
Sirinek
L P
LP
Department of Pediatrics, Ohio State University, Columbus.
O'Dorisio
M S
MS
D015740:Calcitonin Gene-Related Peptide / Q000502:physiology; D002766:Cholecystokinin / Q000502:physiology; D004068:Digestive System Physiological Phenomena; D004723:Endorphins / Q000502:physiology; D007107:Immune System / Q000502:physiology*; D008214:Lymphocytes / Q000502:physiology; D009478:Neuropeptide Y / Q000502:physiology; D013004:Somatostatin / Q000502:physiology; D013373:Substance P / Q000502:physiology; D014660:Vasoactive Intestinal Peptide / Q000502:physiology
D004723:Endorphins; D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D002766:Cholecystokinin; D015740:Calcitonin Gene-Related Peptide