title: Comparison of cefotaxime with ceftriaxone given intramuscularly 12-hourly for community-acquired pneumonia.
abstract: Cefotaxime 1 g intramuscularly (i.m.) 12-hourly was compared with ceftriaxone 1 g i.m. 12-hourly in adult patients requiring hospitalization with uncomplicated community-acquired pneumonia. Fifty-two patients were enrolled and two were subsequently withdrawn, leaving 50 patients who completed the study; 23 received cefotaxime and 27 received ceftriaxone. Clinical cure was achieved in 49 of the 50 patients (98%). One treatment failure occurred in a patient who received ceftriaxone. The only significant pathogen isolated from the pretreatment sputum cultures was Streptococcus pneumoniae (50%). All isolates were sensitive to both drugs. Cefotaxime 1 g i.m. 12-hourly was as effective as ceftriaxone in the treatment of patients with uncomplicated community-acquired pneumonia requiring hospital admission.
authors.affiliation: Ernest Oppenheimer Hospital, Welkom, Orange Free State, South Africa.
authors.forename: R D
authors.initials: RD
authors.lastname: Dansey
authors.forename: P J
authors.initials: PJ
authors.lastname: Jacka
authors.forename: S A
authors.initials: SA
authors.lastname: Strachan
authors.forename: M
authors.initials: M
authors.lastname: Hay
mesh_terms: D000328:Adult; D002439:Cefotaxime / Q000008:administration & dosage / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000188:drug therapy*
chemical_list: D002443:Ceftriaxone; D002439:Cefotaxime