Reduction of the amount of neurotensin retrogradely transported in dopaminergic neurons of senescent rats.
It is now clearly established that fast anterograde axonal transport can be altered during ageing, both in the central and the peripheral nervous systems, but no information is yet available concerning the modifications of fast retrograde axonal transport during senescence. In the present paper, we report the changes occurring in the retrograde axonal transport of neurotensin in dopaminergic neurons of old rats. When iodinated neurotensin was injected into the striatum, a diminution of approximately 50% in the amount of the labelling measured in the ipsilateral substantia nigra was observed in senescent rats by comparison with young adult rats. Nevertheless, the rate of neurotensin transport was not modified. Our results clearly indicate that less neurotensin is transported from the nerve terminals towards the cell bodies in senescent rats which may have possible consequences for dopaminergic neurons.
Castel
M N
MN
Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alforville, Vitry-sur-Seine, France.
Lechardeur
D
D
Blanchard
J C
JC
Laduron
P M
PM
D000818:Animals; D001370:Axonal Transport; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines; D008297:Male; D008870:Microtubules / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D009496:Neurotensin / Q000493:pharmacokinetics*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism*
D006892:Hydroxydopamines; D018028:Receptors, Neurotensin; D017981:Receptors, Neurotransmitter; D009496:Neurotensin; D016627:Oxidopamine; D004298:Dopamine