CSF chromogranin A-like immunoreactivity in schizophrenia. Assessment of clinical and biochemical relationships.
Chromogranin A (CgA) is co-released with catecholamines and peptides and has a wide distribution in the brain. Chromogranin A provides a measure of tonic arousal. CSF CgA-like immunoreactivity (CgA-LI) was studied in 42 drug-free male schizophrenic patients. 33 of these patients were first studied during chronic haloperidol maintenance treatment. Withdrawal from haloperidol maintenance treatment was associated with a significant increase in CSF CgA-LI, particularly in the patients who did not relapse. Contrary to expectation CSF CgA-LI was higher in drug-free patients who slept longer the night before the lumbar puncture. Significant relationships were observed between CSF CgA-LI and CSF homovanillic acid, acetylcholinesterase, neuropeptide Y-LI and 5-hydroxy-indole acetic acid, but not with CSF norepinephrine or 3-methoxy-4-hydroxyphenylglycol. Ventricular brain ratios correlated negatively with CSF CgA-LI levels.
van Kammen
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Highland Drive DVAMC, Pittsburgh, PA 15206.
Peters
J
J
Yao
J
J
Neylan
T
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Beuger
M
M
Pontius
E
E
O'Connor
D T
DT
D000328:Adult; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001284:Atrophy; D001921:Brain / Q000473:pathology; D053379:Chromogranin A; D002864:Chromogranins / Q000134:cerebrospinal fluid*; D006220:Haloperidol / Q000627:therapeutic use; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D011569:Psychiatric Status Rating Scales; D011863:Radioimmunoassay; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000188:drug therapy; D012565:Schizophrenic Psychology
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D006220:Haloperidol; D009638:Norepinephrine; D006719:Homovanillic Acid