The effect of drugs on lung hyperreactivity in Sephadex treated rats.
The injection of Sephadex G200 intravenously into rats induced a blood eosinophilia and an hyper-reactivity of lung parenchymal strips to 5-hydroxytryptamine (5HT) and carbachol. The blood eosinophilia and the hyper-reactivity to 5HT reached a maximum at the same time and before that to carbachol. It was shown previously that the reduction of the blood eosinophilia by treatment with dexamethasone, dapsone, phenidone, isoprenaline and aminophylline also reduced the hyper-reactivity to 5HT. In this study we found that only dexamethasone reduced the hyper-reactivity to carbachol.
Spicer
B A
BA
SmithKline Beecham Pharmaceuticals, Biosciences Research Centre, Epsom, Surrey, U.K.
Baker
R C
RC
Smith
H
H
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D002452:Cell Count / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D003911:Dextrans / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004804:Eosinophils / Q000166:cytology; D008168:Lung / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*
D003911:Dextrans; D012701:Serotonin; D003907:Dexamethasone; D002217:Carbachol; C025614:sephadex