title: Variance of interburst intervals in burst suppression.
abstract: Each EEG performed over a 3 year period at the University of Michigan with a diagnosis of generalized burst-suppression (BS) was reviewed. Ten EEGs from 10 patients with hypoxic-ischemic encephalopathy (HIE-BS) and 21 records from 8 patients with pentobarbital induced burst-suppression for treatment of status epilepticus (SE-BS) were reviewed. For each EEG, the mean duration of 40 interburst intervals (IBIs) as well as their coefficient of variability were calculated. We found that in the SE-BS group the coefficient of variability of IBI duration was highly correlated with the logarithm of mean IBI duration while in the HIE-BS group, there was no significant correlation between these 2 variables. This suggests that the underlying mechanism causing BS is different in the 2 groups and might be related to a uniform and progressive affection of similar brain structures in the SE-BS group and a more patchy and variable pathology in the HIE-BS group.
authors.affiliation: EEG Laboratory, Department of Neurology, University of Michigan, Ann Arbor.
authors.forename: A
authors.initials: A
authors.lastname: Beydoun
authors.forename: C E
authors.initials: CE
authors.lastname: Yen
authors.forename: I
authors.initials: I
authors.lastname: Drury
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D002545:Brain Ischemia / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000503:physiopathology*; D007223:Infant; D008297:Male; D008875:Middle Aged; D010424:Pentobarbital / Q000627:therapeutic use; D013226:Status Epilepticus / Q000188:drug therapy / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D010424:Pentobarbital