Senile dementia and presenile dementia.
Neurotransmitters including acetylcholine, dopamine, norepinephrine, serotonin, GABA and vasopressin were examined in control subjects and patients with Alzheimer-type dementia, involving presenile and senile dementia. Neurotransmitters exhibited various mode of changes with aging. Abnormalities found in senile or presenile dementia were not always parallel to the age-related changes. These results suggest that Alzheimer-type dementia cannot be understood as an accelerated senescence, but other etiological factors might be introduced for the manifestation of the dementia. Moreover, the disturbance in neurotransmitters revealed a difference between presenile Alzheimer's disease and senile dementia, indicating that further studies should be carried out taking the age of onset into consideration.
Nakamura
S
S
Department of Neurology, Faculty of Medicine, Kyoto University.
D000110:Acetylcholinesterase / Q000134:cerebrospinal fluid; D000544:Alzheimer Disease / Q000378:metabolism; D001127:Arginine Vasopressin / Q000032:analysis; D001708:Biopterins / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000473:pathology; D002795:Choline O-Acetyltransferase / Q000032:analysis; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology / Q000378:metabolism; D004299:Dopamine beta-Hydroxylase / Q000032:analysis; D005968:Glutamate Decarboxylase / Q000134:cerebrospinal fluid; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007564:Japan / Q000453:epidemiology; D018377:Neurotransmitter Agents / Q000378:metabolism*
D018377:Neurotransmitter Agents; D001127:Arginine Vasopressin; D001708:Biopterins; D006897:Hydroxyindoleacetic Acid; D004299:Dopamine beta-Hydroxylase; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D005968:Glutamate Decarboxylase; C003402:sapropterin; D006719:Homovanillic Acid