title: Prevention of murine cerebral malaria by a stable prostacyclin analog.
abstract: Iloprost, a synthetic prostacyclin analog, successfully prevents the development of cerebral malaria in mice. Malaria antigen-induced tumor necrosis factor (TNF) production could be inhibited by iloprost in vitro and in vivo. Northern analysis of TNF mRNA revealed that malaria antigen-induced TNF expression was suppressed at the transcription level.
authors.affiliation: Landesinstitut für Tropenmedizin Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Sliwa
authors.forename: H J
authors.initials: HJ
authors.lastname: Grundmann
authors.forename: S
authors.initials: S
authors.lastname: Neifer
authors.forename: M F
authors.initials: MF
authors.lastname: Chaves
authors.forename: G
authors.initials: G
authors.lastname: Sahlmüller
authors.forename: E
authors.initials: E
authors.lastname: Blitstein-Willinger
authors.forename: U
authors.initials: U
authors.lastname: Bienzle
authors.forename: P G
authors.initials: PG
authors.lastname: Kremsner
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D001927:Brain Diseases / Q000517:prevention & control*; D005260:Female; D016285:Iloprost / Q000627:therapeutic use*; D008288:Malaria / Q000517:prevention & control*; D051379:Mice; D008808:Mice, Inbred CBA; D010962:Plasmodium berghei / Q000276:immunology; D012333:RNA, Messenger / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics
chemical_list: D000953:Antigens, Protozoan; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D016285:Iloprost