title: New perspectives on the coagulation cascade.
abstract: The view that clotting is basically a succession of zymogen activations remains valid but is in need of some modifications, in part because the intrinsic and extrinsic coagulation pathways are more closely interrelated than had been thought. The new knowledge is beginning to influence treatment of the hereditary bleeding disorders--and to point the way toward genetic cures.
authors.affiliation: Department of Medicine, University of North Carolina School of Medicine, Chapel Hill.
authors.forename: H R
authors.initials: HR
authors.lastname: Roberts
authors.forename: J N
authors.initials: JN
authors.lastname: Lozier
mesh_terms: D001777:Blood Coagulation / Q000235:genetics / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology; D005165:Factor V / Q000235:genetics / Q000502:physiology; D005169:Factor VIII / Q000235:genetics / Q000502:physiology; D005340:Fibrinogen / Q000235:genetics / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D014812:Vitamin K / Q000235:genetics / Q000502:physiology; D014841:von Willebrand Factor / Q000235:genetics / Q000502:physiology
chemical_list: D001779:Blood Coagulation Factors; D014841:von Willebrand Factor; D014812:Vitamin K; D005165:Factor V; D005169:Factor VIII; D005340:Fibrinogen