[Search for bone marrow donors for patients with hematologic-oncologic diseases].
In recent years, bone marrow transplantation (BMT) has been used as a curative treatment for patients with intractable hematopoietic disorders, such as leukemia. However, lacking other options, only 30 percent of patients will have an HLA-identical family-member bone marrow donor. For patients without HLA-identical family members, HLA-identical, MLC non-reactive unrelated donors have been used. However it is very difficult to find HLA-compatible donors from an unrelated donor registry, due to the highly polymorphic HLA-system. Therefore, we need approximately 6-12 months to find an HLA-matched donor who would agree to donate bone marrow.
Holzberger
G
G
Institut für Immunhämatologie, Universität Frankfurt.
Seidl
S
S
Kühnl
P
P
D016026:Bone Marrow Transplantation / Q000706:statistics & numerical data*; D016206:Databases, Bibliographic; D005858:Germany; D006680:HLA Antigens / Q000032:analysis*; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007391:International Cooperation; D007938:Leukemia / Q000601:surgery*; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000706:statistics & numerical data*
D006680:HLA Antigens
Knochenmark-Fremdspendersuche für Patienten mit hämatologisch-onkologischen Erkrankungen.