An animal investigation into the effects of tympanostomy on middle ear mucociliary function and cilia.
The effect of tympanostomy on guinea-pig middle ear mucosa with particular reference to mucociliary function and cilia was investigated. 13 guinea-pigs were used; 5 acted as the control group with no surgical intervention whilst the other 8 had perforations made in one tympanic membrane. 6 weeks later an attempt was made to measure mucociliary function in all the ears, but this was unsuccessful. However, it would appear that fashioning a perforation in the tympanic membrane causes no histological changes in this animal model.
Smallman
L A
LA
Department of Pathology, Medical School, University of Birmingham, UK.
To
S S
SS
Proops
D W
DW
D000818:Animals; D002606:Charcoal; D002923:Cilia / Q000502:physiology / Q000648:ultrastructure; D004432:Ear, Middle / Q000033:anatomy & histology / Q000502:physiology*; D004848:Epithelium / Q000033:anatomy & histology / Q000502:physiology; D005064:Eustachian Tube / Q000033:anatomy & histology / Q000502:physiology; D006168:Guinea Pigs; D009079:Mucociliary Clearance / Q000502:physiology*; D010030:Ostomy; D011092:Polyethylene Glycols; D013194:Staining and Labeling; D014432:Tympanic Membrane / Q000601:surgery*
D002606:Charcoal; D011092:Polyethylene Glycols