[A study on the inhibition effect of tetrandrine on the pingyangmycinum induced pulmonary fibrosis].
A model of pulmonary fibrosis caused by a single intratracheal injection 0.1 mg pingyangmycinum in mice was reported. The effect of tetrandrine, a herbal powder, 50 mg/kg time, on the pathological development of pulmonary fibrosis, and the activity of superoxide dismutase (SOD), angiotensin converting enzyme (ACE), quantity of hydroxyproline (HYP) in this mice model were investigated. We also contrast tetrandrine with cortisol. The result showed that tetrandrine may inhibit the formation and development of pulmonary fibrosis. On the other hand, tetrandrine and cortisol may increase the activity of SOD of lung tissue, reduce the quantity of HYP of lung tissue and decrease the activity of serum ACE.
Jin
H
H
General Hospital of PLA, Beijing.
D000470:Alkaloids / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic; D044182:Benzylisoquinolines; D001761:Bleomycin / Q000031:analogs & derivatives; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D051379:Mice; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000903:Antibiotics, Antineoplastic; D044182:Benzylisoquinolines; D001761:Bleomycin; C009438:tetrandrine; C021771:zhengguangmycin; D013482:Superoxide Dismutase; D007703:Peptidyl-Dipeptidase A; D006909:Hydroxyproline