Renal effects of nitrendipine.
Calcium-entry blockers exert several characteristic effects on the kidney that potentiate their antihypertensive effect. Long-term therapy with nitrendipine, a dihydropyridine derivative, lowers blood pressure while maintaining renal hemodynamics within limits similar to pretreatment values in essential hypertension with normal renal function. This is accompanied by a persistent natriuretic effect that probably facilitates its antihypertensive action and is not followed by changes of the renin-angiotensin-aldosterone system. Preliminary data also seem to indicate that nitrendipine could be safely used in patients with arterial hypertension and chronic renal failure.
Ruilope
L M
LM
Hypertension Unit, 12 de Octubre Hospital, Madrid, Spain.
D001794:Blood Pressure / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D009318:Natriuresis / Q000187:drug effects*; D009568:Nitrendipine / Q000494:pharmacology / Q000627:therapeutic use*; D012079:Renal Circulation / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects*; D014664:Vasodilation
D009568:Nitrendipine