title: Protective effect of cloricromene, a coumarine derivative, in hypovolemic hemorrhagic shock in the rat.
abstract: Hypovolemic hemorrhagic shock was induced in male anesthetized rats by intermittently withdrawing blood from an iliac catheter over a period of 20 min until mean arterial pressure (MAP) fell to 30 mm Hg. Survival rate, MAP, plasma myocardial depressant factor (MDF) activity and plasma levels of both TxB2 and 6-keto PGF1 alpha were then evaluated. Cloricromene (0.5, 1, and 2 mg/kg) or an equal volume of vehicle (0.9% NaCl solution) were injected intravenously 5 min after the end of the bleeding. Hemorrhagic shocked rats showed enhanced plasma levels of MDF, TxB2 and 6-keto PGF1 alpha. All vehicle-treated rats died within 25 min. Cloricromene (1 and 2 mg/kg) given curatively significantly increased survival rate and blunted the rise in plasma MDF and TxB2. Moreover, cloricromene reversed the severe hypotension and the ST-segment elevation occurring during hemorrhagic shock. The data suggest that cloricromene exerts beneficial effects in experimental hypovolemic shock, probably reversing myocardial failure.
authors.affiliation: Institute of Pharmacology, School of Medicine, University of Messina, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Sturniolo
authors.forename: F
authors.initials: F
authors.lastname: Squadrito
authors.forename: G M
authors.initials: GM
authors.lastname: Campo
authors.forename: R
authors.initials: R
authors.lastname: Vinci
authors.forename: A
authors.initials: A
authors.lastname: Calatroni
authors.forename: M
authors.initials: M
authors.lastname: Prosdocimi
authors.forename: A P
authors.initials: AP
authors.lastname: Caputi
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002866:Chromonar / Q000031:analogs & derivatives* / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects; D008297:Male; D009201:Myocardial Depressant Factor / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D013929:Thromboxane B2 / Q000097:blood
chemical_list: D009201:Myocardial Depressant Factor; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; C025945:cloricromen; D002866:Chromonar