title: [The spatial reorganization of the perinucleolar area of hematopoietic cells in human leukemias].
abstract: The structure of perinucleolar zone in nuclei of peripheral blood hemopoietic cells has been studied. The cells of human patient with chronic lympholeukemia, chronic myeloleukemia, various forms of acute leucosis have been investigated. The phenomenon of radial strings and border structures has been found in these cells. The features have been revealed by visualization of ribonucleoproteides and lipoproteins. The same process takes place in human lymphocytes after 6-24 h of 3-phosphoglyceric aldehyde stimulation in vitro. A comparative study of morphologic peculiarities of hemopoietic cell nucleolar apparatus depending on cell cycle phase has been performed. The action of cytostatics upon the structure of nucleus perinucleolar zone has been investigated.
authors.forename: N V
authors.initials: NV
authors.lastname: Levitan
authors.forename: G N
authors.initials: GN
authors.lastname: Shorina
authors.forename: M M
authors.initials: MM
authors.lastname: Degtiaeva
authors.forename: M I
authors.initials: MI
authors.lastname: Loseva
authors.forename: G S
authors.initials: GS
authors.lastname: Iakobson
authors.forename: M A
authors.initials: MA
authors.lastname: Monakhova
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000188:drug therapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000188:drug therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000188:drug therapy; D010835:Phytohemagglutinins / Q000494:pharmacology; D013194:Staining and Labeling / Q000379:methods
chemical_list: D000970:Antineoplastic Agents; D010835:Phytohemagglutinins
vernacular_title: Prostranstvennaia reorganizatsiia perinukleoliarnoĭ zony gemopoéticheskikh kletok pri leĭkozakh u cheloveka.