Polymorphic phospholipid phase transitions as tools to understand peptide-lipid interactions.
The effect of peptides on bilayer----non-bilayer phase transitions can be used as a tool to investigate the molecular aspects of peptide-lipid interactions. In this contribution the action on membranes of the peptide antibiotic gramicidin A and the bee venom component melittin are compared. Although the known structures and locations of these peptides upon membrane binding are very different, their actions on membranes show striking parallels. A general model is proposed that explains the seemingly complex peptide-lipid interactions by making use of simple concepts.
Tournois
H
H
aATO Agrotechnology, Wageningen, The Netherlands.
de Kruijff
B
B
D000595:Amino Acid Sequence; D006096:Gramicidin / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry; D008555:Melitten / Q000737:chemistry; D008561:Membrane Fusion; D008563:Membrane Lipids / Q000737:chemistry; D008956:Models, Chemical; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*
D008051:Lipid Bilayers; D008563:Membrane Lipids; D010455:Peptides; D010743:Phospholipids; D006096:Gramicidin; D008555:Melitten