title: T-cell-mediated activation of B cells.
abstract: Antibody responses to protein antigens are dependent on helper T lymphocytes, which provide necessary growth and differentiation, inducing stimuli to antigen-specific B cells. Recent investigations have focused on the mechanisms of T-B interactions, and the nature of the T-cell-derived signals that are needed for activation and expansion of B cells.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: H J
authors.initials: HJ
authors.lastname: Burstein
authors.forename: A K
authors.initials: AK
authors.lastname: Abbas
mesh_terms: D000818:Animals; D000917:Antibody Formation; D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D001402:B-Lymphocytes / Q000276:immunology*; D019013:CD40 Antigens; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D019013:CD40 Antigens; D007073:Immunoglobulin E