Reduction in brain serotonin markers by alpha-ethyltryptamine (Monase).
alpha-Ethyltryptamine (Monase) is both an inhibitor of monoamine oxidase and a monoamine releasing agent. To determine whether alpha-ethyltryptamine induces serotonergic deficits similar to that of other monoamine releasing agents such as 3,4-methyl-enedioxymethamphetamine (MDMA) and para-chloroamphetamine (PCA), rats were given multiple doses (8 x 30 mg/kg s.c.) of alpha-ethyltryptamine acetate. Serotonin and 5-hydroxyindole acetic acid (5-HIAA) levels and the number of 5-HT uptake sites (determined from [3H]paroxetine binding) were significantly decreased in frontal cortex samples at one week killing. A significant decrease in 5-HT and 5-HIAA levels was also observed in rat hippocampal samples. The results provide evidence that alpha-ethyltryptamine may induce serotonin neurotoxicity similar to that of MDMA and PCA.
Huang
X M
XM
Purdue University, Department of Pharmacology and Toxicology, West Lafayette, IN 47907.
Johnson
M P
MP
Nichols
D E
DE
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D014363:Tryptamines / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D014363:Tryptamines; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C038034:etryptamine