Immunohistochemical localization of myelin-associated glycoprotein isoforms during the development in the mouse brain.
The developmental changes in localization of myelin-associated glycoprotein (MAG) isoforms in the mouse brain were demonstrated by an immunohistochemical method using antisera specific to two MAG isoforms. The antiserum to the large isoform of MAG (L-MAG) stained the myelin sheaths and the cytoplasm of oligodendroglia in the active myelinating stage in the mouse central nervous system. However, the antiserum to the small isoform of MAG (S-MAG) stained only myelin sheaths in the adult stage. These findings suggest that L-MAG plays an important role in active myelination.
Ishiguro
H
H
Department of Neurology, Niigata University, Japan.
Sato
S
S
Fujita
N
N
Inuzuka
T
T
Nakano
R
R
Miyatake
T
T
D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development / Q000276:immunology; D001923:Brain Chemistry / Q000502:physiology*; D007150:Immunohistochemistry; D007536:Isomerism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009185:Myelin Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D018992:Myelin-Associated Glycoprotein; D009836:Oligodendroglia / Q000737:chemistry / Q000276:immunology / Q000378:metabolism
D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein