title: Anatomical distribution of substance P-immunoreactive neurons in human brainstem during the first postnatal year.
abstract: The localization of substance P (SP)-immunoreactive structures in the infant brainstem was investigated by immunohistochemistry using the peroxidase antiperoxidase technique. SP-immunoreactive structures are widely distributed throughout the brainstem region. SP-immunoreactive cell bodies are prominent in the superior colliculis, the central grey, the nucleus tractus solitarius and the reticular formation. A high density of SP-immunoreactive fibers is found in the nucleus tractus solitarius, the trigeminal nucleus and the dorsal horn of the spinal cord. Large SP-immunoreactive fibers are seen in the substantia nigra. In the present study, we also investigated the development of substance P-immunoreactive fibers in the infant brainstem during the first postnatal year. We note a qualitative increase in the density of SP-immunoreactivity in some brainstem regions such as colliculus superior and substantia nigra with respect to age.
authors.affiliation: Laboratoire d'Anatomie Pathologique, Faculté de Médecine Alexis Carrel, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Chigr
authors.forename: M
authors.initials: M
authors.lastname: Najimi
authors.forename: P
authors.initials: P
authors.lastname: Leduque
authors.forename: J A
authors.initials: JA
authors.lastname: Chayvialle
authors.forename: R
authors.initials: R
authors.lastname: Bouvier
authors.forename: N
authors.initials: N
authors.lastname: Kopp
mesh_terms: D000375:Aging; D001933:Brain Stem / Q000033:anatomy & histology / Q000254:growth & development* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D009928:Organ Specificity; D013373:Substance P / Q000032:analysis*; D014279:Trigeminal Nucleus, Spinal / Q000033:anatomy & histology / Q000254:growth & development / Q000473:pathology
chemical_list: D013373:Substance P