Oxygen free radicals and pelvic adhesion formation: II. The interaction of oxygen free radicals and adhesion-preventing solutions.
A three-part animal and in vitro study gives evidence that oxygen free radicals are produced by intraperitoneal macrophages in response to pelvic surgery. These macrophages appear to ingest high-molecular-weight substances used to prevent adhesions (such as 32% dextran 70 and carboxymethylcellulose). However, the production of oxygen free radicals is not enhanced by the presence of 32% dextran 70 or carboxymethyl cellulose.
Elkins
T E
TE
Department of Obstetrics and Gynecology, University of Michigan Medical Center, Ann Arbor.
Warren
J
J
Portz
D
D
McNeeley
S G
SG
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000494:pharmacology* / Q000627:therapeutic use; D003911:Dextrans / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005609:Free Radicals; D066298:In Vitro Techniques; D008247:Lysosomes / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011817:Rabbits; D051381:Rats; D013481:Superoxides / Q000378:metabolism; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
D003911:Dextrans; D005609:Free Radicals; D013481:Superoxides; D002266:Carboxymethylcellulose Sodium; D010100:Oxygen