[The parasitism characteristics of the causative agent of melioidosis in the host cells].
The electron microscopic study of the damaged areas of the lungs, liver, spleen and lymph nodes of guinea pigs infected with two P. pseudomallei virulent strains C-141 and 100 has revealed that this organism is a facultative intracellular parasite and exhibits tropism to reticuloendothelial cells of the body, parasitizing both in "professional" phagocytes (mononuclear, phagocytes, polymorphonuclear leukocytes) and "nonprofessional" phagocytes (capillary endotheliocytes, splenic and lymph-node reticulocytes). In the course of their intracellular development P. pseudomallei have been shown to form capsules protecting the pathogens from the unfavorable action of the protective mechanisms of the host cells.
Popov
S F
SF
Kurilov
V Ia
VIa
Mel'nikov
B I
BI
D000208:Acute Disease; D000818:Animals; D016957:Burkholderia pseudomallei / Q000472:pathogenicity*; D006168:Guinea Pigs; D006790:Host-Parasite Interactions; D008099:Liver / Q000382:microbiology / Q000648:ultrastructure; D008168:Lung / Q000382:microbiology / Q000648:ultrastructure; D008198:Lymph Nodes / Q000382:microbiology / Q000648:ultrastructure; D008554:Melioidosis / Q000382:microbiology*; D008854:Microscopy, Electron; D013154:Spleen / Q000382:microbiology / Q000648:ultrastructure; D014774:Virulence
Osobennosti parazitirovaniia vozbuditelia melioidoza v kletkakh khoziaina.