title: Characterization of a cell surface adhesion molecule expressed by a subset of developing chick neurons.
abstract: We have isolated a 105-kDa membrane glycoprotein expressed by subsets of developing chick neurons. This glycoprotein, identified by the JC7 monoclonal antibody, is present on the surface of axons and cell bodies of developing spinal motor neurons, dorsal root ganglion sensory neurons, sympathetic and parasympathetic neurons, and a small subset of brain neurons. Late in development the JC7 antigen is expressed at high levels on CNS nonneuronal glial-like cells. When attached to latex beads this glycoprotein can mediate homophilic adhesion and when used as a culture substrate stimulates a highly branched pattern of neurite outgrowth from dorsal root ganglion explants. The JC7 antigen appears to be identical to the SC1, BEN, and DM antigens. Its limited distribution, adhesive qualities, and ability to stimulate neurite outgrowth suggest it may play a role in the selective growth of neural processes during development.
authors.affiliation: Department of Physiology and Neurobiology, University of Connecticut, Storrs 06269-3042.
authors.forename: S
authors.initials: S
authors.lastname: el-Deeb
authors.forename: S C
authors.initials: SC
authors.lastname: Thompson
authors.forename: J
authors.initials: J
authors.lastname: Covault
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D015816:Cell Adhesion Molecules, Neuronal / Q000737:chemistry* / Q000276:immunology / Q000502:physiology; D002478:Cells, Cultured; D002642:Chick Embryo; D039841:Leukocyte L1 Antigen Complex; D051379:Mice; D009474:Neurons / Q000737:chemistry* / Q000276:immunology / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D015816:Cell Adhesion Molecules, Neuronal; D039841:Leukocyte L1 Antigen Complex