title: Nebulized heparin and anabolic steroid in the prevention of postoperative deep vein thrombosis following elective abdominal surgery.
abstract: One hundred eighty three patients, all over 40 years old, who underwent major abdominal surgery, were randomized into 3 groups: Group I received a single dose of nebulized heparin (800 IU per kg b.w.) administered by inhalation one day prior to surgery. Group II besides the above, also received a single injection of 50 mg of long acting anabolic steroid (nandrolone phenylpropionate) intramuscularly. Group III received 5000 IU heparin subcutaneously on hr prior to surgery as well as every 12 h for the next 5 postoperative days. Postoperatively the patients were evaluated for deep vein thrombosis (DVT) using the 125-I-fibrinogen test. The occurrence of DVT was determined as: in Group I--16%, in Group II--7.9%, in Group III--7.8%. Haemorrhagic complications (clinically important) were observed in 7.8% of patients from Group III, but only in 1.7% of patients in Group I and 1.6% in Group II. For DVT prophylaxis following abdominal surgery a single application of nebulized heparin and long acting anabolic steroid is as effective as conventional low-dose subcutaneous heparin administration, but gives less haemorrhagic complications. This method is also more advantagenous in term of acceptance by the patients and represents considerable saving of nursing time.
authors.affiliation: Department of Haematology, Academy of Medicine, Poznań, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Zawilska
authors.forename: A
authors.initials: A
authors.lastname: Tokarz
authors.forename: A
authors.initials: A
authors.lastname: Misiak
authors.forename: P
authors.initials: P
authors.lastname: Psuja
authors.forename: S
authors.initials: S
authors.lastname: Wisławski
authors.forename: P
authors.initials: P
authors.lastname: Szymczak
authors.forename: J
authors.initials: J
authors.lastname: Meissner
authors.forename: J
authors.initials: J
authors.lastname: Karoń
authors.forename: K
authors.initials: K
authors.lastname: Lewandowski
authors.forename: S
authors.initials: S
authors.lastname: Lopaciuk
mesh_terms: D000005:Abdomen; D045930:Anabolic Agents / Q000627:therapeutic use*; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009330:Nebulizers and Vaporizers; D011183:Postoperative Complications / Q000517:prevention & control*; D011655:Pulmonary Embolism / Q000517:prevention & control*; D013924:Thrombophlebitis / Q000517:prevention & control*
chemical_list: D045930:Anabolic Agents; D009277:Nandrolone; D006493:Heparin; C008580:nandrolone phenpropionate