Complement evasion strategies of microorganisms.
The success of microorganisms as human pathogens stems partly from their ability to evade recognition and/or avoid destruction by complement and other natural and acquired defense mechanisms. Here, Neil Cooper reviews the various mechanisms that pathogens have evolved to evade the destructive actions of the complement system, with particular emphasis on the many remarkable examples of the duplication of complement-like structural and functional epitopes by microorganisms. Such mimicry not only enables the pathogens to avoid destruction by complement-mediated mechanisms but also, in a number of instances, facilitates infection.
Cooper
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NR
Dept of Immunology, Scripps Research Institute, La Jolla, CA 92037.
D001426:Bacterial Proteins / Q000276:immunology; D003167:Complement Activation / Q000276:immunology; D015938:Complement Membrane Attack Complex / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005656:Fungal Proteins / Q000276:immunology; D006801:Humans; D007239:Infections / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
D001426:Bacterial Proteins; D015938:Complement Membrane Attack Complex; D000939:Epitopes; D005656:Fungal Proteins; D015800:Protozoan Proteins; D014764:Viral Proteins; D003165:Complement System Proteins