title: Isolation and sequence determination of cDNA encoding the major structural protein of human peripheral myelin.
abstract: A full length cDNA of the major structural protein of peripheral myelin (P0 protein) has been isolated from a cDNA library of human fetus spinal cord. The clone is 1948 base pairs (bp) in length and contains a 744 bp open reading frame encoding a polypeptide of 248 residues including 29 signal peptide. The deduced amino acid sequence is highly homologous to P0 protein from other species.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hayasaka
authors.forename: K
authors.initials: K
authors.lastname: Nanao
authors.forename: M
authors.initials: M
authors.lastname: Tahara
authors.forename: W
authors.initials: W
authors.lastname: Sato
authors.forename: G
authors.initials: G
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Uyemura
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D005333:Fetus; D015723:Gene Library; D006801:Humans; D008969:Molecular Sequence Data; D018993:Myelin P0 Protein; D009185:Myelin Proteins / Q000235:genetics*; D009186:Myelin Sheath / Q000502:physiology; D016366:Open Reading Frames; D051381:Rats; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013116:Spinal Cord / Q000502:physiology
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D004247:DNA