Auto-anti-D blocking D determinants on red cells in pregnancy.
Positive direct antiglobulin test due to IgG1 autoantibody of anti-D specificity on red cells of an apparently healthy pregnant woman was found. At the period of the highest autoantibody activity D epitope were completely blocked and even by special methods used for Rh typing in patients with AIHA the detection of D antigen was not possible. Free auto-anti-D caused benign HDN in the infant. The autoantibody production was transient and stopped after delivery. D variant included into category V on the red cells of the patient under study and her two siblings was recognized. This finding, confirmed by in vitro study, gives the explanation of the complete blocking of D epitopes by anti-D autoantibody.
Kuśnierz-Alejska
G
G
Department of Serology, Institute of Haematology, Warszawa, Poland.
Bugajna
I
I
Seyfried
H
H
D000328:Adult; D001323:Autoantibodies / Q000235:genetics / Q000276:immunology; D003298:Coombs Test; D000939:Epitopes / Q000276:immunology*; D004899:Erythroblastosis, Fetal / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000276:immunology; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology*
D001323:Autoantibodies; D000939:Epitopes; D012204:Rh-Hr Blood-Group System