Effect of insulin on serotonin, 5-hydroxyindole-acetic acid, norepinephrine, epinephrine and corticosterone contents in chick.
Pineal serotonin (5-HT), 5-hydroxyindole-acetic acid (5-HIAA), norepinephrine (NE), epinephrine (E) and adrenal corticosterone, NE and E contents were measured spectrofluorometrically 5, 15, 30 and 60 min after insulin treatment to induce hypoglycemic stress. In the pineal gland, hypoglycemic stress caused dramatic decrease of 5-HT, resulted in initial decrease followed by an increase of 5-HIAA and brought about changes of NE and E. Corticosterone content in the adrenal gland increased significantly following treatment with insulin. Adrenal NE and E contents plummetted to control value followed by quick resynthesis. The findings indicate that insulin-induced hypoglycemia greatly modulates the activities of pineal and adrenal glands.
Mahata
S K
SK
Department of Zoology, University of Calcutta, India.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D002645:Chickens; D003345:Corticosterone / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010084:Oxidation-Reduction; D010870:Pineal Gland / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
D001679:Biogenic Amines; D007328:Insulin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine