An immunohistochemical survey of pS2 expression in human epithelial cancers.
The oestrogen-inducible pS2 protein isolated from human breast-cancer cells appears to have prognostic significance in breast-cancer patients. Using both monoclonal and polyclonal pS2 anti-sera, we have carried out an immunocytochemical survey of 9 epithelial cancers. Some degree of specific tumour staining was observed in 4 tissues, the extent varying greatly between specimens. Most (11/13) of the colorectal cancers showed immunoreactivity, as did 4/5 pancreatic carcinomas. In some of these cases, patchy staining was also observed in adjacent non-tumour cells. Two bronchio-alveolar carcinomas showed positivity, but 5 poorly differentiated adenocarcinomas of the lung did not. In the ovary, staining was observed in 3/3 mucinous cystadenocarcinomas but only in 1/8 of the serous type. No reactivity was seen in specimens of salivary gland, kidney, liver, prostate or uterus. This pilot study indicates that pS2 may be a useful marker of adenocarcinomas in human neoplasms apart from those in the breast, and suggests that more extensive surveys might be worthwhile.
Luqmani
Y A
YA
Department of Medical Oncology, Charing Cross Hospital Medical School, London, UK.
Ryall
G
G
Shousha
S
S
Coombes
R C
RC
D000230:Adenocarcinoma / Q000235:genetics; D000906:Antibodies; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D003110:Colonic Neoplasms / Q000235:genetics; D003536:Cystadenocarcinoma / Q000235:genetics; D005260:Female; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D010051:Ovarian Neoplasms / Q000235:genetics; D011506:Proteins; D012468:Salivary Gland Neoplasms / Q000235:genetics; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins
D000906:Antibodies; D000911:Antibodies, Monoclonal; D009363:Neoplasm Proteins; D011506:Proteins; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins