[The spatial reorganization of the perinucleolar area of hematopoietic cells in human leukemias].
The structure of perinucleolar zone in nuclei of peripheral blood hemopoietic cells has been studied. The cells of human patient with chronic lympholeukemia, chronic myeloleukemia, various forms of acute leucosis have been investigated. The phenomenon of radial strings and border structures has been found in these cells. The features have been revealed by visualization of ribonucleoproteides and lipoproteins. The same process takes place in human lymphocytes after 6-24 h of 3-phosphoglyceric aldehyde stimulation in vitro. A comparative study of morphologic peculiarities of hemopoietic cell nucleolar apparatus depending on cell cycle phase has been performed. The action of cytostatics upon the structure of nucleus perinucleolar zone has been investigated.
Levitan
N V
NV
Shorina
G N
GN
Degtiaeva
M M
MM
Loseva
M I
MI
Iakobson
G S
GS
Monakhova
M A
MA
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002466:Cell Nucleolus / Q000187:drug effects / Q000648:ultrastructure*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000648:ultrastructure*; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000188:drug therapy; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000188:drug therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000188:drug therapy; D010835:Phytohemagglutinins / Q000494:pharmacology; D013194:Staining and Labeling / Q000379:methods
D000970:Antineoplastic Agents; D010835:Phytohemagglutinins
Prostranstvennaia reorganizatsiia perinukleoliarnoĭ zony gemopoéticheskikh kletok pri leĭkozakh u cheloveka.