title: Walking track analysis: a long-term assessment of peripheral nerve recovery.
abstract: Functional recovery following sciatic, tibial, and peroneal nerve injury was assessed over a 1-year period using walking track analysis in the rat. Internal neurolysis did not affect nerve function. Crush injury induced a temporary, but complete, loss of function that recovered to control levels by 4 weeks. Nerve transection resulted in complete loss of function without any evidence of recovery. After nerve repair, functional recovery occurred, reaching near-optimal recovery by 12 weeks. The degree of functional recovery varied with the specific nerve involved. The sciatic nerve recovered 41 percent of function, whereas the tibial nerve recovered 54 percent of function. The peroneal nerve exhibited the highest degree of recovery, achieving functional levels similar to control values. Assessment of neural regeneration using walking track analysis appears to be a valuable addition to the traditional methods of histology and electrophysiology.
authors.affiliation: Department of Surgery, Washington University, St. Louis, Mo.
authors.forename: G M
authors.initials: GM
authors.lastname: Hare
authors.forename: P J
authors.initials: PJ
authors.lastname: Evans
authors.forename: S E
authors.initials: SE
authors.lastname: Mackinnon
authors.forename: T J
authors.initials: TJ
authors.lastname: Best
authors.forename: J R
authors.initials: JR
authors.lastname: Bain
authors.forename: J P
authors.initials: JP
authors.lastname: Szalai
authors.forename: D A
authors.initials: DA
authors.lastname: Hunter
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D008124:Locomotion; D008297:Male; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000502:physiology*; D010543:Peroneal Nerve / Q000293:injuries / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000293:injuries / Q000502:physiology; D013979:Tibial Nerve / Q000293:injuries / Q000502:physiology; D013997:Time Factors