[The mechanisms of cellular complementarity in the erythroblast islands of the bone marrow].
Phenylhydrazine was shown to reduce the content of erythroblast islands (EI) within 24 hrs in the rat bone marrow, the effect depending on the dose. Simultaneous strengthening of phagocytic activity, acidifying of lysosomes central macrophages EI and lowering of electrophoretic mobility, were observed. The proteinase inhibitor contrycal (50 and 500 i. u.) prevented the effect in the EI and intensified the regeneration of erythron. In vitro, trypsin and chymotrypsin decreased the EI content in the marrow cell suspension. Changing of functional condition of the central macrophages EI and, probably, products of its secretion, seems to affect the cell complementing in EI.
Rassokhin
A G
AG
Zakharov
Iu M
IuM
Krest'ianinova
O G
OG
Kruglov
D G
DG
Potapov
P Iu
PIu
D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D001854:Bone Marrow Cells; D002918:Chymotrypsin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004586:Electrophoresis; D004900:Erythroblasts / Q000187:drug effects / Q000502:physiology*; D004920:Erythropoiesis / Q000187:drug effects / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000187:drug effects / Q000502:physiology; D008297:Male; D010659:Phenylhydrazines / Q000494:pharmacology; D051381:Rats; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology
D010659:Phenylhydrazines; C030299:phenylhydrazine; D007611:Aprotinin; D002918:Chymotrypsin; D014357:Trypsin
O nekotorykh mekhanizmakh komplementarnosti kletok v éritroblasticheskikh ostrovkakh kostnogo mozga.