Absence of malignant hyperthermia contractures in Becker-Duchenne dystrophy at age 2.
Two 2-year-old males underwent muscle biopsy that established the histopathologic diagnosis of Becker dystrophy in one, and Duchenne dystrophy in the other. Concomitant contracture testing with caffeine or halothane was normal for malignant hyperthermia (MH). The results suggest that acute hypermetabolism or acute rhabdomyolysis during anesthesia, in patients with these disorders, is related to the X-linked myopathy and its associated muscle deterioration, rather than to the autosomal dominant MH.
Gronert
G A
GA
Department of Anesthesiology, University of California, Davis 95616.
Fowler
W
W
Cardinet
G H
GH
Grix
A
A
Ellis
W G
WG
Schwartz
M Z
MZ
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003286:Contracture / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008305:Malignant Hyperthermia / Q000150:complications*; D009132:Muscles / Q000473:pathology; D009136:Muscular Dystrophies / Q000150:complications* / Q000473:pathology