title: The judicial use of venous duplex imaging and strain gauge plethysmography (single or combined) in the diagnosis of acute and chronic deep vein thrombosis.
abstract: Sixty-eight patients (79 limbs) with clinically suspected deep vein thrombosis were evaluated by duplex imaging, strain gauge plethysmography and venography. The diagnostic accuracies were projected over a spectrum of disease incidences ranging from 10 to 90 per cent of the population. The sensitivity, specificity, positive and negative predictive values, and over-all accuracy in detecting acute deep vein thrombosis were 90.9, 87.1, 83.3, 93.1, and 88.7 per cent, respectively, for venous duplex imaging, and 81.8, 69.6, 56.3, 88.9 and 73.5 per cent, respectively, for strain gauge plethysmography. The positive predictive value and over-all accuracy of venous duplex imaging were statistically significantly higher than that of strain gauge plethysmography. When both tests were combined and compared with venous duplex imaging alone, none of these parameters were statistically significant. For chronic deep vein thrombosis, the sensitivity, specificity, positive predictive value, negative predictive value and over-all accuracy for venous duplex imaging were 75, 86, 80, 86 and 82 per cent, respectively. Fourteen per cent had inconclusive results obtained at venous duplex imaging. When strain gauge plethysmography was combined with venous duplex imaging, the over-all accuracy was 82 per cent. As the true incidence of the disease increases, the positive accuracy differences between strain gauge plethysmography and venous duplex imaging decrease to a negligible level. We concluded that over-all, venous duplex imaging is superior. However, the strain gauge plethysmography has reasonable accuracy and may be used in places where venous duplex imaging is not available. Combined use of venous duplex imaging and strain gauge plethysmography would be helpful in patients with inconclusive results obtained at venous duplex imaging and, as the true incidence increases, the positive accuracy rate of strain gauge plethysmography becomes close to that of venous duplex imaging.
authors.affiliation: Department of Surgery, West Virginia University Health Sciences Center, Charleston.
authors.forename: A F
authors.initials: AF
authors.lastname: AbuRahma
authors.forename: W
authors.initials: W
authors.lastname: Kennard
authors.forename: P A
authors.initials: PA
authors.lastname: Robinson
authors.forename: J P
authors.initials: JP
authors.lastname: Boland
authors.forename: L L
authors.initials: LL
authors.lastname: Young
authors.forename: S
authors.initials: S
authors.lastname: Alberts
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D010991:Plethysmography; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014463:Ultrasonography