True histiocytic neoplasm of Langerhans' cell type.
Malignant histiocytic neoplasms of dendritic cell lineage are rare and most are derived from the dendritic cells of the T-cell and B-cell areas of the lymph node, respectively. Only one case of a malignant histiocytic neoplasm of Langerhans' cells, the dendritic cell of the skin, has been reported. We report the occurrence of a true histiocytic neoplasm of Langerhans' cell type in a 23-year-old female patient. The diagnosis of this highly aggressive neoplasm is supported by histochemical, immunohistochemical, ultrastructural, and genotypic analysis--techniques which allow differentiation from malignant melanoma and large cell anaplastic lymphoma.
Delabie
J
J
Department of Pathology II, University Hospital, K.U. Leuven, Belgium.
De Wolf-Peeters
C
C
De Vos
R
R
Vandenberghe
E
E
Kennes
K
K
De Jonge
I
I
Desmet
V
V
D000328:Adult; D000951:Antigens, Neoplasm; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D013194:Staining and Labeling
D000951:Antigens, Neoplasm