title: [Ribonucleotide reductase--transition enzymes from RNA metabolism to DNA metabolism].
abstract: Ribonucleotide reductases catalyze the reduction of ribonucleotides to deoxyribonucleotides, this reaction being vitally important for all organisms. The enzyme provides a link between RNA and DNA metabolisms. Several forms of the enzyme occur in nature and those differ in their structure and catalytic mechanisms. While the direct reduction of ribonucleotides via a radical mechanism is a general mode of dNTP synthesis in all organisms, the way in which this is achieved varies. The ability of the enzyme to control DNA synthesis is of considerable clinical interest. Selective inhibition of DNA synthesis is desired, for example, in clinical applications, such as restriction of tumour growth or virus replication.
authors.affiliation: Faculty of Natural Sciences, Komensky University, Bratislava, Czechoslovakia.
authors.forename: M
authors.initials: M
authors.lastname: Kollarova
authors.forename: O
authors.initials: O
authors.lastname: Labudova
mesh_terms: D002384:Catalysis; D004247:DNA / Q000378:metabolism*; D011487:Protein Conformation; D012313:RNA / Q000378:metabolism*; D012264:Ribonucleotide Reductases / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D012313:RNA; D004247:DNA; D012264:Ribonucleotide Reductases
vernacular_title: Ribonukleotid-reduktazy--énzymy perekhoda ot metabolizma RNK k metabolizmu DNK.