title: Technetium-99m-DTPA aerosol and gallium-67 scanning in pulmonary complications of human immunodeficiency virus infection.
abstract: We retrospectively compared the results of 67Ga chest scans and 99mTc-DTPA aerosol clearance measurements with those of fiberoptic bronchoscopy in 88 patients infected with the human immunodeficiency virus. Of 100 investigations, a pulmonary infection was diagnosed in 39, mainly Pneumocystis carinii pneumonia and a noninfectious disorder was found in 42, mainly Kaposi's sarcoma and lymphocytic alveolitis. Gallium scans and DTPA clearance were abnormal respectively in 74% and 92% of infectious complications, and in 12% and 60% of noninfectious disorders. In 10 cases, DTPA clearance was accelerated, while chest x-ray, arterial blood gases and even gallium scanning were normal. A value of DTPA clearance greater than 4.5%.min-1 was both sensitive and specific for the diagnosis of Pneumocystis carinii pneumonia. The gallium scan was always normal in bronchopulmonary Kaposi's sarcoma. We conclude that in symptomatic patients: (1) DTPA clearance measurements are useful for detecting lung disease when chest x-ray and/or PaO2 are normal and (2) a gallium scan is indicated to distinguish progressive Kaposi's sarcoma from a superimposed second process when radiological abnormalities of pulmonary Kaposi's sarcoma are present.
authors.affiliation: Hôpital Henri Mondor, Service de Médecine Nucléaire, Créteil, France.
authors.forename: J
authors.initials: J
authors.lastname: Rosso
authors.forename: J M
authors.initials: JM
authors.lastname: Guillon
authors.forename: A
authors.initials: A
authors.lastname: Parrot
authors.forename: M
authors.initials: M
authors.lastname: Denis
authors.forename: G
authors.initials: G
authors.lastname: Akoun
authors.forename: C
authors.initials: C
authors.lastname: Mayaud
authors.forename: M
authors.initials: M
authors.lastname: Scherrer
authors.forename: M
authors.initials: M
authors.lastname: Meignan
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D001999:Bronchoscopy; D005710:Gallium Radioisotopes / Q000378:metabolism; D006679:HIV Seropositivity / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012907:Smoking / Q000009:adverse effects; D016284:Technetium Tc 99m Pentetate / Q000378:metabolism
chemical_list: D005710:Gallium Radioisotopes; D016284:Technetium Tc 99m Pentetate