title: [Isovolemic hemodilution on non-arteritic anterior optic neuropathy. Initial results of a randomized study].
abstract: As there is no generally accepted treatment for non-inflammatory anterior ischemic optic neuropathy, we have started a randomized, controlled clinical trial on isovolemic hemodilution. In this study all patients received a basic treatment of 75 mg of acetylsalicyclic acid daily. Patients were then randomly assigned to either a group without additional therapy or a group with isovolemic hemodilution. Isovolemic hemodilution was carried out over 6 weeks by several blood-letting procedures and replacement of volume by infusion of hydroxyethyl starch solutions (PCV down to 35-32%). So far, 21 patients have fulfilled the inclusion criteria (symptoms less than or equal to 30 days, no medical contraindications, no giant-cell arteritis), and since they matched for age, duration of symptoms, cardiovascular risk factors, they could be observed for at least 3 months. Although only 1 of 10 control patients hat better visual acuity after 3 months; 6 out of 11 hemodiluted patients had better vision after treatment (p = 0.024). These results indicate that isovolemic hemodilution most likely has a beneficial effect on the visual prognosis of patients with anterior ischemic neuropathy.
authors.affiliation: Universitäts-Augenklinik, Freiburg, Bundesrepublick Deutschland.
authors.forename: L L
authors.initials: LL
authors.lastname: Hansen
authors.forename: J
authors.initials: J
authors.lastname: Wiek
authors.forename: M
authors.initials: M
authors.lastname: Danisevskis
authors.forename: W
authors.initials: W
authors.lastname: Schrader
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage; D007511:Ischemia / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009900:Optic Nerve / Q000098:blood supply*; D014792:Visual Acuity / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D001241:Aspirin
vernacular_title: Isovolämische Hämodilution bei nichtarteriitischer anteriorer Optikusneuropathie. Erste Ergebnisse einer randomisierten Studie.