T-cell recognition of myelin basic protein.
Multiple sclerosis is a chronic inflammatory disease of the central nervous system which has been hypothesized to be autoimmune in nature. To test whether this is the case, Kai Wucherpfennig and colleagues have developed a set of criteria that must be met to satisfy the hypothesis. Here, they present these criteria and assess the extent to which studies to date satisfy them.
Wucherpfennig
K W
KW
Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA.
Weiner
H L
HL
Hafler
D A
DA
D001324:Autoantigens; D001327:Autoimmune Diseases / Q000209:etiology / Q000628:therapy; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D009103:Multiple Sclerosis / Q000209:etiology / Q000628:therapy; D004676:Myelin Basic Protein / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens; D004676:Myelin Basic Protein; D011948:Receptors, Antigen, T-Cell