[Effects on bone marrow during stimulation of hematopoietic stem cells with recombinant human interleukin-3].
Bone marrow aspirates and biopsies of 20 patients with malignant tumors (n = 6), bone marrow failure due to chemotherapy (n = 4), myelodysplastic syndromes (n = 5) and aplastic anemia (n = 5) were analysed before and after treatment with recombinant human interleukin-3. rhIL-3 led to increased overall bone marrow cellularity with trilinear stimulation of hematopoietic cells. In all patients marked eosinophilia and, in some, fibrosis was observed. These results show that rhIL-3 stimulates the proliferation and differentiation of pluripotent hematopoietic progenitor cells and may contribute to the treatment of bone marrow failure.
Falk
S
S
Senckenbergisches Zentrum der Pathologie, Johann Wolfgang Goethe-Universität Frankfurt/M.
Seipelt
G
G
Ganser
A
A
Hoelzer
D
D
Stutte
H J
HJ
Hübner
K
K
D000741:Anemia, Aplastic / Q000473:pathology* / Q000628:therapy; D000970:Antineoplastic Agents / Q000009:adverse effects; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007377:Interleukin-3 / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000473:pathology* / Q000628:therapy; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy; D011994:Recombinant Proteins / Q000627:therapeutic use
D000970:Antineoplastic Agents; D007377:Interleukin-3; D011994:Recombinant Proteins
Knochenmarksbefunde bei Stimulation hämatopoietischer Stammzellen mit rekombinantem humanen Interleukin-3.