title: Aortic valve replacement and splenectomy in a patient with chronic idiopathic thrombocytopenic purpura--preoperative management with high-dose gamma-globulin.
abstract: We report the management of a patient with chronic idiopathic thrombocytopenic purpura and severe aortic valvular disease. Preoperative intravenous high-dose gamma-globulin administration was employed, and aortic valve replacement combined with splenectomy were performed during the same operation. The platelet count at admission was 34,000/mm3 and increased to 146,000/mm3 after the gamma-globulin therapy. Platelet transfusion at the end of the cardiopulmonary bypass was considered no longer necessary in the postoperative period, because the platelet count increased quickly after the procedure. The postoperative course was uneventful. We believe that open heart surgery and splenectomy can successfully be performed simultaneously in a patient with chronic idiopathic thrombocytopenic purpura treated with high-dose gamma-globulin therapy.
authors.affiliation: Second Department of Surgery, Oita Medical College, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Hadama
authors.forename: H
authors.initials: H
authors.lastname: Takasaki
authors.forename: K
authors.initials: K
authors.lastname: Oka
authors.forename: O
authors.initials: O
authors.lastname: Shigemitsu
authors.forename: S
authors.initials: S
authors.lastname: Miyamoto
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: H
authors.initials: H
authors.lastname: Anai
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
mesh_terms: D001022:Aortic Valve Insufficiency / Q000276:immunology / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000276:immunology / Q000601:surgery*; D001323:Autoantibodies / Q000032:analysis; D006350:Heart Valve Prosthesis; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000276:immunology / Q000601:surgery*; D012086:Reoperation; D013156:Splenectomy; D005719:gamma-Globulins / Q000627:therapeutic use*
chemical_list: D001323:Autoantibodies; D005719:gamma-Globulins