Proteoglycan epitope in synovial fluid in gonarthrosis. 28 cases of tibial osteotomy studied prospectively for 2 years.
High tibial osteotomy was performed for medial gonarthrosis in 28 patients. Preoperatively, and at 3, 12, and 24 months after surgery, clinical and radiographic examinations were made, and joint-fluid samples were aspirated. Arthroscopy was performed preoperatively and at 24 months. Immunoassay of proteoglycan epitope in joint fluid showed an increase in concentration at all times as compared with a reference population with normal knee joints. An increase in both the concentration and the total amount of proteoglycan epitope in joint fluid was noted at 3 months postoperatively with a return to preoperative values at later times. Regrowth of fibrocartilage did not correlate with proteoglycan epitope data.
Odenbring
S
S
Lund University Hospital, Department of Orthopedics, Sweden.
Egund
N
N
Lindstrand
A
A
Lohmander
L S
LS
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000601:surgery; D000939:Epitopes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010027:Osteotomy; D011446:Prospective Studies; D011509:Proteoglycans / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism*
D000939:Epitopes; D011509:Proteoglycans