A case of homozygous sickle cell disease in Sri Lanka.
An 11 year old Muslim boy with a 2 month history of fever, loss of appetite, pallor and abdominal distension, had hepato-splenomegaly. Haemoglobin electrophoresis showed the presence of haemoglobins S and F, with complete absence of haemoglobin A. The sickling test was positive. Marital consanguinity was present. In both parents, the sickling test was positive and haemoglobin electrophoresis showed the presence of haemoglobins A and S. This is the first report of homozygous sickle cell disease in Sri Lanka.
Lucas
G N
GN
Lady Ridgeway Hospital, Colombo.
Jayawardena
D R
DR
D000755:Anemia, Sickle Cell / Q000097:blood / Q000235:genetics*; D002648:Child; D003241:Consanguinity; D005319:Fetal Hemoglobin / Q000235:genetics; D006441:Hemoglobin A / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male
D006451:Hemoglobin, Sickle; D006441:Hemoglobin A; D005319:Fetal Hemoglobin