Comparison between the effects of dietary saturated (16:0), monounsaturated (18:1), and polyunsaturated (18:2) fatty acids on plasma lipoprotein metabolism in cebus and rhesus monkeys fed cholesterol-free diets.
Cebus and rhesus monkeys were fed cholesterol-free diets providing 40% of energy as fat for 6-wk periods. The fats were high-linoleic acid safflower oil (HLSO), high-oleic acid safflower oil (HOSO), or palm oil (PO), rich in polyunsaturated (18:2), monounsaturated (18:1), or saturated (16:0) fatty acids, respectively. In cebus monkeys, plasma cholesterol concentrations during HLSO intake were 17-19% lower than those during HOSO or PO intake, attributed to a decrease in high-density lipoprotein (HDL). Plasma triglyceride (TG) and low-density-lipoprotein (LDL) cholesterol concentrations were comparable during all dietary treatments. Sixty-eight percent of total LDL catabolism was receptor mediated in all dietary groups and this was associated with similar apolipoprotein B pool sizes and fractional catabolic rates. Rhesus monkeys revealed similar cholesterol concentrations (total, LDL, and HDL) during all dietary treatments. TG concentrations during PO intake were 34% and 63% higher than those during HOSO and HLSO intakes, respectively. Hence, dietary 16:0 and 18:1 produce similar effects on LDL and HDL metabolism in normocholesterolemic primates.
Khosla
P
P
Foster Biomedical Research Laboratory, Brandeis University, Waltham, MA 02254.
Hayes
K C
KC
D000818:Animals; D002428:Cebus; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008253:Macaca mulatta; D008297:Male; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol