Centrally administered galanin inhibits osmotically stimulated arginine vasopressin release in conscious rats.
The effect of centrally administered galanin on arginine vasopressin (AVP) release was investigated in conscious rats. Intracerebroventricular injection of porcine galanin suppressed hypertonic saline-induced increase in plasma AVP in a dose-dependent manner (12.5-100 pmol/rat) at 10 min after the injection. Pretreatment with subcutaneous injection of naloxone (1 mg/100 g b.wt.) partially blocked the galanin-induced effect on plasma AVP. These results suggest that central galanin inhibits osmotically stimulated AVP release and endogenous opioids are, at least in part, involved in the mechanism.
Kondo
K
K
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Murase
T
T
Otake
K
K
Ito
M
M
Oiso
Y
Y
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D019004:Galanin; D006982:Hypertonic Solutions / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009994:Osmolar Concentration; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006982:Hypertonic Solutions; D010455:Peptides; D001127:Arginine Vasopressin; D009270:Naloxone; D019004:Galanin