title: Variations in polymer fitness at elevated mutation rates.
abstract: Two series expressions were obtained that give the first and second order rates of change in population fitness during competitive replication at elevated mutation rates. At their zero-error limit, the respective power series reduces to the second (Fisher's theorem) and third moments of the fitness distribution. The first series maximized the variation in mean polymer fitness, for a given amount of population covariance. From experimental results reported by Spiegelman's group on evolution in vitro among Q beta RNA variants, it was demonstrated: (i) terms in the (second) series fall-off at a rate broadly equal to the replicase error (epsilon congruent to 10(-4); (ii) the rate of change in mean RNA fitness (polymer formation rate constant) corresponds to the variance in fitness; and (iii) agreement exists between second order rate changes in fitness and the third moment (skewness) regression line, extending over 20 successive replication reactions. The impact of these findings on the standard model of evolution has been discussed.
authors.affiliation: Research Foundation of Southern California, Inc., La Jolla 92037.
authors.forename: B K
authors.initials: BK
authors.lastname: Davis
mesh_terms: D005075:Biological Evolution; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D012313:RNA / Q000235:genetics*
chemical_list: D012313:RNA