title: Bradycardia and syncope in children not controlled by pacing: beta-adrenergic hypersensitivity.
abstract: Cardiac pacing is frequently employed in the therapy of children with syncope and documented bradycardia. This report describes two children, ages 7 and 9 years, who underwent placement of demand ventricular pacing systems for documented bradycardia and syncope. Cardiac catheterization and intracardiac electrophysiological studies failed to show evidence of structural abnormalities, sinus node or conduction system disease, inducible arrhythmias, or VA conduction in each patient. Both patients had persistent symptoms after pacemaker implantation. Autonomic function testing with continuous heart rate and blood pressure monitoring revealed exaggerated beta-adrenergic responses to simple standing and small doses of isoproterenol. Symptoms were completely eliminated with atenolol. In these two children, cardiac pacing alone was not adequate for relief of symptoms. Autonomic mechanisms of bradycardia and hypotension should be considered prior to implantation of permanent pacing systems in children.
authors.affiliation: Lillie Frank Abercrombie Section of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston 77030.
authors.forename: J C
authors.initials: JC
authors.lastname: Perry
authors.forename: R A
authors.initials: RA
authors.lastname: Friedman
authors.forename: J P
authors.initials: JP
authors.lastname: Moak
authors.forename: A
authors.initials: A
authors.lastname: Garson
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D001262:Atenolol / Q000627:therapeutic use; D001341:Autonomic Nervous System / Q000503:physiopathology; D001919:Bradycardia / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000009:adverse effects; D008297:Male; D013575:Syncope / Q000150:complications / Q000188:drug therapy / Q000628:therapy*
chemical_list: D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D007545:Isoproterenol