title: Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro.
abstract: The effects of an immunopotentiating drug, isoprinosine, on the splenocytes of BALB/c mice to produce cytokines were investigated. Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro. It also significantly increased the IFN-gamma secretion and decreased the IL-4 production in vivo. The significance of these findings in terms of immune regulation is discussed.
authors.affiliation: Institute of General Pathology, University of Palermo, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Milano
authors.forename: M
authors.initials: M
authors.lastname: Dieli
authors.forename: S
authors.initials: S
authors.lastname: Millott
authors.forename: M D
authors.initials: MD
authors.lastname: Miceli
authors.forename: E
authors.initials: E
authors.lastname: Maltese
authors.forename: E
authors.initials: E
authors.lastname: Cillari
mesh_terms: D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D007542:Inosine Pranobex / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007377:Interleukin-3 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology
chemical_list: D007376:Interleukin-2; D007377:Interleukin-3; D015847:Interleukin-4; D007371:Interferon-gamma; D007542:Inosine Pranobex