[Preoperative treatment of esophageal cancer with oral peplomycin jelly].
Pepleo-jelly, peplomycin (PEP) compounded with sodium polyacrylate (PANa), was used as a local preoperative chemotherapy for esophageal cancer. Thirty milligrams of PEP emulsified in 10 ml of jelly was orally administered for 17 patients on consecutive bed time, and the average total dose was 470 mg. Concentrations of PEP in blood and tissue were measured with a bioassay. PEP was not detected in the blood but was detected in esophageal tissue and regional lymphnodes. A significant difference (p less than 0.05) of tissue concentrations between normal esophageal mucosa (0.11 microgram/g) and malignant region (0.34 microgram/g) was noted. Furthermore, PEP was detected in many regional lymphnodes. Histological antitumor effect (Ef2) was noted in three of the eight metastatic lymphnodes. A side effect of this treatment was not recognized. It is believed that this treatment is safe and useful in combination with other adjuvant cancer therapy.
Sasamoto
M
M
First Dept. of Surgery, Hirosaki University, School of Medicine, Japan.
Kako
N
N
Tani
A
A
Iwabuchi
T
T
Sekine
T
T
Iwabuchi
S
S
Hasegawa
Y
Y
Kokubun
H
H
Fukushima
M
M
Koie
H
H
D000180:Acrylic Resins / Q000008:administration & dosage / Q000493:pharmacokinetics; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001761:Bleomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017663:Peplomycin; D011300:Preoperative Care
D000180:Acrylic Resins; D000970:Antineoplastic Agents; D001761:Bleomycin; C006903:carbopol 940; D017663:Peplomycin