title: Suggestive evidence for a microanatomical relationship between mast cells and nerve fibres containing substance P, calcitonin gene related peptide, vasoactive intestinal polypeptide, and somatostatin in the rat mesentery.
abstract: A close microanatomical relationship between serotonin-positive mast cells and nerve fibres positive for substance P, calcitonin gene related peptide, vasoactive intestinal polypeptide, and somatostatin has been observed in whole-mount preparations of rat mesentery by an immunofluorescent double-staining procedure. Peptidergic fibres have been shown either to run in close proximity or come in direct contact with mast cells. This supports earlier morphological and immunohistochemical results suggesting an innervation of mast cells and provides a structural foundation for a series of pharmacological studies which outline the influence of various neuropeptides on mast cell secretory activity.
authors.affiliation: Institute of Experimental and Clinical Morphology, Faculty of Medicine, University of Udine, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Crivellato
authors.forename: D
authors.initials: D
authors.lastname: Damiani
authors.forename: F
authors.initials: F
authors.lastname: Mallardi
authors.forename: L
authors.initials: L
authors.lastname: Travan
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D007150:Immunohistochemistry; D008407:Mast Cells / Q000737:chemistry* / Q000648:ultrastructure*; D008643:Mesentery / Q000737:chemistry* / Q000166:cytology*; D009412:Nerve Fibers / Q000737:chemistry* / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000032:analysis*; D013373:Substance P / Q000032:analysis*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
chemical_list: D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D015740:Calcitonin Gene-Related Peptide