The acute effect of topical epinephrine on macular blood flow in humans.
The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated leukocytes on a computer screen to match that of their own entoptically perceived leukocytes before instilling the drug and 2 hr thereafter. An artificial tear solution was instilled into the fellow eye for a control. Epinephrine instillation resulted in a 8% increase in macular leukocyte velocity and presumably blood flow (P less than 0.03, paired student t-test).
Robinson
F
F
Department of Ophthalmology, University of Pennsylvania School of Medicine.
Chen
S
S
Petrig
B L
BL
Grunwald
J E
JE
Riva
C E
CE
D000287:Administration, Topical; D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries; D004837:Epinephrine / Q000494:pharmacology*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008266:Macula Lutea / Q000098:blood supply* / Q000187:drug effects; D008875:Middle Aged; D011897:Random Allocation
D004837:Epinephrine