Crystallization of the Fab fragments of anti-peptide monoclonal antibodies and a complex with peptide.
The antigen-binding fragments of four monoclonal antibodies that cross-react with both the "loop" peptide of hen egg-white lysozyme (residues 57 to 84) against which they were raised, and with the native protein (HEL) have been crystallized. One of these fragments also crystallizes as a complex with the peptide antigen.
Griest
R E
RE
Laboratory of Molecular Biophysics, Oxford, Great Britain.
Jeffrey
P D
PD
Taylor
G L
GL
Rees
A R
AR
D000818:Animals; D000911:Antibodies, Monoclonal / Q000648:ultrastructure; D003461:Crystallography; D007140:Immunoglobulin Fab Fragments / Q000648:ultrastructure*; D007074:Immunoglobulin G / Q000737:chemistry; D046911:Macromolecular Substances; D051379:Mice; D009113:Muramidase / Q000737:chemistry / Q000276:immunology; D010455:Peptides / Q000737:chemistry* / Q000276:immunology
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D046911:Macromolecular Substances; D010455:Peptides; D009113:Muramidase