title: [Immunologic defects in the lymphatic system of the intestinal mucosa in common variable immunodeficiency (CVID) syndrome].
abstract: The humoral immune system of the intestinal mucosa of patients with common variable immuno deficiency (CVID) syndrome was studied immunohistologically using antibodies against immunoglobulin (Ig) A1-2, M and G1-4, against the J chain and the secretory component. In 9/13 CVID-patients IgA-positive cells were totally absent whereas a total IgM-defect was found only in 3/14 patients. Considerable numbers of J chain-positive cells were present in all CVID-patients irrespective of the extent of the Ig-defect indicating the presence of early B-cells unable to differentiate and to produce Ig. There was a strong expression of the secretory component in the cytoplasm and at the surface of enterocytes even in those CVID-patients who were totally defective in IgA- and IgM-positive cells.
authors.affiliation: Pathologisches Institut, Universität Freiburg.
authors.forename: E W
authors.initials: EW
authors.lastname: Herbst
authors.forename: M
authors.initials: M
authors.lastname: Armbruster
authors.forename: J A
authors.initials: JA
authors.lastname: Rump
authors.forename: H P
authors.initials: HP
authors.lastname: Buscher
authors.forename: H H
authors.initials: HH
authors.lastname: Peter
mesh_terms: D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007144:Immunoglobulin J-Chains / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D008208:Lymphatic System / Q000276:immunology* / Q000473:pathology; D012635:Secretory Component / Q000032:analysis
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007144:Immunoglobulin J-Chains; D007075:Immunoglobulin M; D012635:Secretory Component
vernacular_title: Immundefekte des lymphatischen Systems der Darmschleimhaut bei variablem Immundefektsyndrom (common variable immuno deficiency (CVID)-Syndrom).