Alpha-methylserotonin, a substitute transmitter for serotonergic neurons.
1. Administration to rats of alpha-methyltryptophan (AMTP) gives rise to alpha-(AM5HT) in the brain along with a decrease of cerebral 5HT. 2. Analysis of fractions prepared from brains of AMTP-injected rats shows that AM5HT occurs mainly in the synaptosomes. 3. The synaptosomal content of AM5HT in proportion to the total AM5HT in the brain represents the same ratio as for the corresponding fractions of 5HT.
Sourkes
T L
TL
Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
Montine
T J
TJ
Missala
K
K
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012701:Serotonin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
C020774:alpha-methyltryptophan; C042390:alpha-methylserotonin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan