K+ efflux pathways and neurotransmitter release associated to hippocampal ischemia: effects of glucose and of K+ channel blockers.
Ischemia of hippocampal slices leads to 86Rb+ efflux and to amino acid neurotransmitter release. This 86Rb+ efflux which corresponds to the massive K+ efflux from neuronal cells observed in ischemic animals is inhibited by glucose (IC50 = 1.7 mM). Glucose also inhibits the ischemia induced liberation of GABA and aspartate. 86Rb+ efflux is insensitive to any type of known blockers for ATP-sensitive, Ca2(+)-sensitive and voltage-sensitive K+ channels.
Schaeffer
P
P
Institut de Pharmacologie moléculaire et cellulaire, Valbonne, France.
Lazdunski
M
M
D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D001030:Apamin / Q000494:pharmacology; D001224:Aspartic Acid / Q000378:metabolism; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002545:Brain Ischemia / Q000503:physiopathology*; D002122:Calcium Chloride / Q000494:pharmacology; D018999:Charybdotoxin; D002712:Chlorides; D004546:Elapid Venoms / Q000494:pharmacology; D005913:Glipizide / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology*; D005905:Glyburide / Q000494:pharmacology; D006624:Hippocampus / Q000098:blood supply* / Q000502:physiology / Q000503:physiopathology; D066298:In Vitro Techniques; D007700:Kinetics; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012413:Rubidium / Q000378:metabolism*; D012604:Scorpion Venoms / Q000494:pharmacology; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D017609:Barium Compounds; D002712:Chlorides; D004546:Elapid Venoms; D015221:Potassium Channels; D012604:Scorpion Venoms; D013757:Tetraethylammonium Compounds; C024986:barium chloride; D018999:Charybdotoxin; D001030:Apamin; D001464:Barium; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D019789:Tetraethylammonium; C020273:dendrotoxin; D015761:4-Aminopyridine; D005947:Glucose; D002122:Calcium Chloride; D012413:Rubidium; D011188:Potassium; D005905:Glyburide; D005913:Glipizide