Chemoprophylaxis of scrapie in mice.
Three applications of the polyanion pentosanpolysulphate about 2 months before infection of mice with scrapie completely protected animals infected with up to 100 LD50, and considerably prolonged the lifespan of those infected with 100 to 10,000 LD50. The clinical diagnosis was confirmed by immunoblot analysis for the protein of scrapie-associated fibrils.
Diringer
H
H
Robert Koch-Institut des Bundesgesundheitsamtes, Berlin, Germany.
Ehlers
B
B
D000818:Animals; D001923:Brain Chemistry; D015151:Immunoblotting; D051379:Mice; D009419:Nerve Tissue Proteins / Q000032:analysis; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use* / Q000633:toxicity; D018622:PrP 27-30 Protein; D012608:Scrapie / Q000188:drug therapy / Q000517:prevention & control*
D009419:Nerve Tissue Proteins; D018622:PrP 27-30 Protein; D010426:Pentosan Sulfuric Polyester