title: Human growth plate development in the fetal and neonatal period.
abstract: The development of the normal human upper tibial growth plate was studied at autopsy in 46 stillborns and 79 newborns of 20-41 weeks gestational age. During this time period, the histology of this plate evolves from a highly cellular structure with relatively poor columnar organization and matrix development to the well known structure seen later in postnatal life. The thickness of the growth plate, assessed in the area surrounding the longitudinal tibial axis, decreases continuously from 1.15 mm on the 20th week to 0.6 mm on the 38th week. This decrease results from losses of both matrix and cellular components, mostly of the latter. However, the relative fraction of area occupied by the matrix significantly increased (12%) and matrix area per cell increased 1.5 times over the last half of gestation, indicating a maturation process of the plate towards a more matrix-oriented structure with age. In this maturation process the number of cells per unit area does not change and the average size of the cells appears to decrease. Plate thickness does not decrease further in the final 3 weeks of pregnancy and increases in early neonatal life; this has no apparent influence on the tibial growth rate. In the period under study the relative anatomical participation of the upper tibial growth plate decreases from approximately 4% of the radiographic length of the tibia on the 20th week to less than 1% at term. Present data will provide fetal and neonatal growth plate standards needed to obtain a better understanding of this structure during both normal and abnormal conditions.
authors.affiliation: Department of Pathology, La Paz Hospital, Madrid, Spain.
authors.forename: J I
authors.initials: JI
authors.lastname: Rodriguez
authors.forename: S
authors.initials: S
authors.lastname: Razquin
authors.forename: J
authors.initials: J
authors.lastname: Palacios
authors.forename: V
authors.initials: V
authors.lastname: Rubio
mesh_terms: D001857:Bone Matrix / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005260:Female; D006132:Growth Plate / Q000166:cytology / Q000196:embryology* / Q000254:growth & development; D006801:Humans; D007231:Infant, Newborn / Q000254:growth & development*; D008297:Male; D013977:Tibia / Q000196:embryology / Q000254:growth & development