Kinetics of the ontogenic and reversible hemoglobin switching in the mouflon (Ovis musimon) and sheep x mouflon hybrid.
1. Hemoglobin (Hb) switching in the perinatal life of wild mouflon (Ovis musimon) was characterized by the replacement of Hb F by 60% levels of Hb C, and subsequently of Hb C by Hb B. 2. The recently discovered Hb M variant was not replaced by Hb C; thus, Hb BM heterozygote newborns synthesized 30% Hb C at the expense of Hb B. 3. Hybrid B mouflon x B sheep synthesized only 5% Hb C at birth but were able to produce 30% Hb C in adult life following induced anemia. 4. Adult BB and BM mouflons, after the same extent of induced anemia, synthesized HB C levels similar to those produced at birth. The results indicate a mouflon beta-globin gene cluster arrangement similar to those of sheep and goat, the beta C gene having an intermediate expression. Results also suggest a selective disadvantage in hybrid animals.
Masala
B
B
Istituto di Fisiologia Generale e Chimica Biologica, Università di Sassari, Italy.
Manca
L
L
Cocco
E
E
Ledda
S
S
Naitana
S
S
D000818:Animals; D005319:Fetal Hemoglobin / Q000235:genetics*; D006444:Hemoglobin C / Q000235:genetics*; D006824:Hybridization, Genetic; D007700:Kinetics; D010641:Phenotype; D012418:Ruminants / Q000097:blood* / Q000235:genetics / Q000254:growth & development; D012756:Sheep / Q000097:blood* / Q000235:genetics / Q000254:growth & development
D006444:Hemoglobin C; D005319:Fetal Hemoglobin