Escherichia coli transcription factor that both activates fatty acid synthesis and represses fatty acid degradation.
The fadR gene of Escherichia coli encodes a protein that acts as a negative regulator (repressor) of the inducible beta-oxidation pathway. We report that the FadR protein also functions as a positive transcriptional activator of the fabA gene, which encodes the enzyme introducing the double bond of the unsaturated fatty acids of E. coli.
Henry
M F
MF
Department of Microbiology, University of Illinois, Urbana 61801.
Cronan
J E
JE
D001426:Bacterial Proteins; D015152:Blotting, Northern; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D005227:Fatty Acids / Q000096:biosynthesis / Q000378:metabolism*; D005798:Genes, Bacterial; D012329:RNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D015183:Restriction Mapping; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C057119:FadR protein, Bacteria; D005227:Fatty Acids; D012329:RNA, Bacterial; D012097:Repressor Proteins