Change of cerebral glucose metabolism by antineoplastic drug.
To estimate change of cerebral glucose metabolism by anticancer drugs, positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) was performed in 11 patients with malignancies who did not show neurological symptoms. In a patient treated with intravenous high-dose methotrexate (HD-MTX) and intrathecal MTX, apparent decrease of glucose metabolism was observed. HD-MTX and intrathecal MTX may cause cerebral glucose metabolism disorder primarily. Cerebral glucose metabolism was also mildly reduced by chemotherapy with drugs other than MTX and by radiotherapy outside the brain, with a corresponding change of blood data. It may reflect a psychosomatic change in whole body.
Okada
J
J
Department of Radiology, Chiba University, School of Medicine, Japan.
Yoshikawa
K
K
Imazeki
K
K
Uno
K
K
Minoshima
S
S
Itami
J
J
Maruno
H
H
Kuyama
J
J
Arimizu
N
N
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000627:therapeutic use; D003847:Deoxyglucose / Q000031:analogs & derivatives; D003907:Dexamethasone / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000532:radiotherapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D014055:Tomography, Emission-Computed; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use
D019788:Fluorodeoxyglucose F18; D001761:Bleomycin; D014750:Vincristine; D005047:Etoposide; D003907:Dexamethasone; D004317:Doxorubicin; D003520:Cyclophosphamide; D003847:Deoxyglucose; D005947:Glucose; D011241:Prednisone; D008727:Methotrexate