Disease specificity of antibodies to poly (ADP-ribose); their relationships to anti-DNA antibodies and to disease activity in lupus.
In this study we have measured the level of anti poly (ADP-ribose) antibodies in the sera of a number of patients with SLE and their relatives, patients with a wide variety of other autoimmune and infectious diseases, and a group of normal healthy controls. It was found that these antibodies were not disease specific but were present in nine out of thirteen groups tested in significant numbers. The levels of anti poly (ADP-ribose) antibodies and anti DNA antibodies in SLE patients bled serially were also measured. The level of these antibodies fluctuated in parallel in many of these patients, although the anti poly (ADP-ribose) antibodies reflected disease activity more accurately in some.
Le Page
S H
SH
Department of Rheumatology Research, University College and Middlesex School of Medicine, London.
Dudeney
C
C
Shall
S
S
Shoenfeld
Y
Y
Isenberg
D A
DA
D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology; D003429:Cross Reactions; D000939:Epitopes; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D011064:Poly Adenosine Diphosphate Ribose / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D000939:Epitopes; D011064:Poly Adenosine Diphosphate Ribose