title: Effects of exercise and other nonpharmacological measures on blood pressure and cardiac hypertrophy.
abstract: Reversal of left ventricular hypertrophy (LVH) is an important target of antihypertensive therapy. Nonpharmacological approaches such as weight reduction and exercise training have favorable effects on other risk factors. However, there are few data on their effects on LVH. Athletes have eccentric rather than concentric LVH. A 12-month exercise program in 13 unmedicated hypertensive subjects altered LV geometry, reducing LV wall thickness and increasing LV internal diameters (LVID). LV mass was unchanged, and the thickness/radius fell by 9%. Shorter-term studies have shown that the cardiac structural changes with a moderate exercise program occur rapidly and their onset lags only about 2 weeks behind blood pressure (BP) effects. Assessment of weight loss effects on LVH is complicated by the strong relationship between body weight and ventricular wall thickness. LVID, and LV mass. To some extent, this can be overcome by arbitrarily indexing to body surface area or height. The wall thickness/radius ratio is not related to body size. Weight reduction reduces BP and thickness/radius by 10% in controlled trials. Small studies have also reported reduction in LV mass after sodium restriction in hypertensive subjects. Studies with other nonpharmacological measures could make a substantial contribution to knowledge of their efficacy.
authors.affiliation: Alfred & Baker Medical Unit, Alfred Hospital, Melbourne, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Jennings
authors.forename: A
authors.initials: A
authors.lastname: Dart
authors.forename: I
authors.initials: I
authors.lastname: Meredith
authors.forename: P
authors.initials: P
authors.lastname: Korner
authors.forename: E
authors.initials: E
authors.lastname: Laufer
authors.forename: E
authors.initials: E
authors.lastname: Dewar
mesh_terms: D001794:Blood Pressure; D006332:Cardiomegaly / Q000628:therapy*; D004039:Diet, Sodium-Restricted; D015444:Exercise; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D015431:Weight Loss