title: Decreases in repetitive extrasystole threshold in the conscious pig with myocardial infarct were reversed by tyrosine.
abstract: Reports indicate that the administration of tyrosine, the precursor amino acid for catecholaminergic neurotransmitters, may be beneficial under conditions of physiologic stress. We studied the effects of tyrosine on vulnerability to ventricular arrhythmia in conscious pigs with healing myocardial infarcts, and sham operated (intact) pigs. Mean arterial pressure and heart rate were measured via chronically implanted aortic catheters. The repetitive extrasystole threshold (defined as the energy in milliamperes (ma) needed to cause a spontaneous ventricular beat following a premature beat induced by an electrical impulse), was measured via a bipolar pacing catheter placed during instrumentation surgery in the apex of the right ventricle. One week after infarct, the myocardial infarct group was studied before and ninety minutes after the administration of tyrosine (8 mg/kg iv). Before tyrosine, the myocardial infarct group had a significantly lower repetitive extrasystole threshold (12 +/- 1 ma) compared to the intact group (19 +/- 2 ma). Ninety minutes after tyrosine, the repetitive extrasystole threshold in the myocardial infarct group was 17 +/- 1 ma. The availability of tyrosine did not alter the repetitive extrasystole threshold in the intact group. Thus, vulnerability to ventricular arrhythmia was enhanced in pigs with recent myocardial infarction. Tyrosine, which can be nutritionally manipulated, may reduce myocardial vulnerability to arrhythmia after infarct.
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115.
authors.forename: J M
authors.initials: JM
authors.lastname: Pinto
authors.forename: D A
authors.initials: DA
authors.lastname: Kirby
authors.forename: T J
authors.initials: TJ
authors.lastname: Maher
authors.forename: B
authors.initials: B
authors.lastname: Lown
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000517:prevention & control; D001794:Blood Pressure / Q000187:drug effects; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000503:physiopathology; D002395:Catecholamines / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D011897:Random Allocation; D013552:Swine; D014443:Tyrosine / Q000008:administration & dosage* / Q000097:blood; D014633:Valine / Q000008:administration & dosage
chemical_list: D002395:Catecholamines; D014443:Tyrosine; D014633:Valine