Sequence of the rabbit neurofilament protein L.
In the course of screening a rabbit brain cDNA library with a probe for the H neurofilament protein, we identified a neurofilament L-cDNA. Its nucleotide sequence is 88% identical to that of human, indicating that L is highly conserved among species. The similarities between the sequences of L from rabbit and mouse suggest that the species-specific accumulation of neurofilaments that occurs in rabbit during aluminum intoxication is not a consequence of the primary structure of L.
Soppet
D R
DR
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110.
Beasley
L L
LL
Willard
M B
MB
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D001921:Brain / Q000502:physiology*; D004247:DNA / Q000235:genetics; D015723:Gene Library; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016900:Neurofilament Proteins / Q000235:genetics*; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D011487:Protein Conformation; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger; D011817:Rabbits; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid; D013552:Swine
D016900:Neurofilament Proteins; D012333:RNA, Messenger; C044882:neurofilament protein L; D011061:Poly A; D012313:RNA; D004247:DNA