Drug-induced haemolysis and renal failure in children with glucose-6-phosphate dehydrogenase deficiency in Afghanistan.
Twenty children (18 boys and 2 girls) with a proven or presumptive diagnosis of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency developed intravascular haemolysis following administration of antimalarials in 9, chloroquine and chloramphenicol in 1, chloroquine, chloramphenicol and aspirin in 1, chloramphenicol and aspirin in 3, and aspirin alone in 4. Eleven of these children developed acute renal insufficiency. All were managed with supportive care, including blood transfusion, forced diuresis and peritoneal dialysis wherever indicated. Only 16 children recovered completely. The occurrence of G-6-PD deficiency is being reported for the first time in Afghanistan.
Choudhry
V P
VP
Department of Paediatrics, Indira Gandhi Institute of Child Health, Kabul, Afghanistan.
Ghafary
A
A
Zaher
M
M
Qureshi
M A
MA
Fazel
I
I
Ghani
R
R
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000209:etiology; D000293:Adolescent; D000346:Afghanistan / Q000453:epidemiology; D000962:Antimalarials / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D002701:Chloramphenicol / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008297:Male
D000962:Antimalarials; D002701:Chloramphenicol; D001241:Aspirin