title: Plasma inorganic fluoride with sevoflurane anesthesia: correlation with indices of hepatic and renal function.
abstract: The biotransformation and plasma inorganic fluoride ion production of sevoflurane (the new volatile anesthetic) during and after surgical anesthesia was studied in 50 ASA I or II surgical patients. Twenty-five additional patients served as controls by receiving isoflurane. Sevoflurane or isoflurane was administered with a semiclosed (total gas flow, 2 L/min O2) circle absorption system for durations of 1.0 to greater than 7.0 minimal alveolar concentration (MAC) hours for surgical anesthesia (sevoflurane MAC, 2.05%; isoflurane MAC, 1.15%). Preoperative and postoperative blood urea nitrogen and creatinine concentrations were determined. Blood samples were obtained during and after anesthesia in both groups for determining anesthetic blood concentration analysis and plasma fluoride level. Plasma fluoride concentrations did not significantly increase during isoflurane anesthesia. Sevoflurane biotransformation produced a mean peak plasma inorganic fluoride concentration of 29.3 +/- 1.8 mumol/L, 2 h after anesthesia, which decreased to 18 mumol/L concentration by 8 h after anesthesia. The peak plasma inorganic fluoride ion concentration correlated with duration of sevoflurane anesthetic exposure. Five patients given sevoflurane had peak levels transiently exceeding 50 mumol/L, and one of these had a history of ingesting drugs potentially producing hepatic enzyme induction. No increases in postoperative levels of creatinine, blood urea nitrogen, direct bilirubin, or hepatic transaminase and no changes in serum electrolyte level occurred in either anesthetic group. Indirect bilirubin concentration increased significantly after sevoflurane anesthesia, but the increase was not of clinical significance (from 0.30 +/- 0.03 to 0.38 +/- 0.06 mg/dL). Indirect bilirubin concentrations did not increase after isoflurane anesthesia; the concentrations reached 0.31 +/- 0.04 mg/dL and did not differ significantly from those found with sevoflurane.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesiology, University of Arizona Health Sciences Center, Tucson 85724.
authors.forename: E J
authors.initials: EJ
authors.lastname: Frink
authors.forename: H
authors.initials: H
authors.lastname: Ghantous
authors.forename: T P
authors.initials: TP
authors.lastname: Malan
authors.forename: S
authors.initials: S
authors.lastname: Morgan
authors.forename: J
authors.initials: J
authors.lastname: Fernando
authors.forename: A J
authors.initials: AJ
authors.lastname: Gandolfi
authors.forename: B R
authors.initials: BR
authors.lastname: Brown
mesh_terms: D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000493:pharmacokinetics*; D004987:Ethers / Q000493:pharmacokinetics*; D005459:Fluorides / Q000097:blood*; D006801:Humans; D007530:Isoflurane / Q000493:pharmacokinetics*; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008738:Methyl Ethers; D000077149:Sevoflurane
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D005459:Fluorides