Fetal alcohol delays the developmental expression of myelin basic protein and transferrin in rat primary oligodendrocyte cultures.
This study has examined the development of immunoreactive myelin basic protein and transferrin in primary glial cell cultures. Cultures were initiated from control and experimental Sprague-Dawley rats 1-2 days postnatally. Experimental treatment involved exposure to 5% (w/v) ethanol in a liquid diet during the last two weeks of gestation. Prenatal alcohol administration delayed the expression of myelin basic protein and transferrin during the first three weeks postnatally. Other oligodendroglial and astroglial markers were little affected, if at all, by fetal alcohol exposure.
Chiappelli
F
F
Brain Research Institute, University of California, Los Angeles 90024.
Taylor
A N
AN
Espinosa de los Monteros
A
A
de Vellis
J
J
D000818:Animals; D002450:Cell Communication; D002478:Cells, Cultured; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D005333:Fetus / Q000187:drug effects*; D007150:Immunohistochemistry; D004676:Myelin Basic Protein / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism* / Q000473:pathology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D014168:Transferrin / Q000378:metabolism*
D004676:Myelin Basic Protein; D014168:Transferrin; D000431:Ethanol