NMR studies of an FK-506 analogue, [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding.
Petros
A M
AM
Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park, Illinois 60064.
Gampe
R T
RT
Gemmecker
G
G
Neri
P
P
Holzman
T F
TF
Edalji
R
R
Hochlowski
J
J
Jackson
M
M
McAlpine
J
J
Luly
J R
JR
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry*; D007166:Immunosuppressive Agents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D016559:Tacrolimus / Q000031:analogs & derivatives; D022021:Tacrolimus Binding Proteins; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D002352:Carrier Proteins; D007166:Immunosuppressive Agents; C058028:immunomycin; D022021:Tacrolimus Binding Proteins; D016559:Tacrolimus