Pargyline and gamma-butyrolactone enhance tyrosine hydroxylase immunostaining of nigrostriatal axons.
Administration of pargyline or gamma-butyrolactone enhanced immunostaining of tyrosine hydroxylase immunoreactive axons in the striatum. The qualitative characteristics of the enhancement were compound dependent and the enhancement was not associated with an increase in the amount of tyrosine hydroxylase within the striatum. These results demonstrate the pharmacological enhancement of immunostaining for neurotransmitter synthetic enzymes in the absence of increased synthesis.
Haykal-Coates
N
N
Mantech Environmental Technology Inc., Research Triangle Park, NC 27709.
O'Callaghan
J P
JP
Reinhard
J F
JF
Jensen
K F
KF
D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000201:enzymology*; D003342:Corpus Striatum / Q000201:enzymology*; D005260:Female; D007150:Immunohistochemistry; D051379:Mice; D008810:Mice, Inbred C57BL; D010293:Pargyline / Q000494:pharmacology*; D013194:Staining and Labeling; D013378:Substantia Nigra / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
D010293:Pargyline; D014446:Tyrosine 3-Monooxygenase; D015107:4-Butyrolactone