The distinctive specificity of antigen-specific suppressor T cells.
Although suppressor T cells have been cloned in only a few instances, the existence of a functional cadre of T cells that acts to downregulate the immune response is well documented. In this review Eli Sercarz and Urszula Krzych describe studies on suppressor T-cell (TS-cell) specificity that provide some support for the conclusion that the TS cell is a distinctive cell type with an expressed repertoire that is different from that expressed by helper T (TH) cells. They go on to explore the interaction between cells recognizing TS-cell-inducing determinants (SDs) and TH-cell-inducing determinants (HDs), and their relationship to immunogenicity and Ir gene effects.
Sercarz
E
E
Dept of Microbiology and Molecular Genetics, University of California, Los Angeles 90024-1489.
Krzych
U
U
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology; D015202:Protein Engineering; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000941:Antigens; D000939:Epitopes; D010446:Peptide Fragments