Autoantibodies to glycoprotein antigens mediate subacute demyelinating encephalomyelitis in the Lewis rat.
Serum autoantibodies were induced in Lewis rats by immunization with a mixture of lentil lectin-binding glycoproteins isolated from bovine brain myelin. Intraperitoneal administration of 2-10 million syngeneic myelin basic protein-activated spleen cells to these rats led within 4-5 days to paralysis which, in most cases, persisted for several weeks. The major neuropathological features of the disease were numerous macrophages in both brain and spinal cord and large areas of demyelination, generally with axon preservation, particularly adjacent to the pial surfaces of the cord. This model is easily induced and will be useful for studies of demyelination and remyelination.
Gautam
A M
AM
Multiple Sclerosis Society Laboratory, Institute of Neurology, London, U.K.
Voccia
I
I
Munro
P M
PM
Nolan
C
C
Brown
A
A
Wylie
S
S
Glynn
P
P
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D002352:Carrier Proteins / Q000276:immunology; D002417:Cattle; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology; D006023:Glycoproteins / Q000276:immunology*; D007114:Immunization; D037102:Lectins / Q000378:metabolism; D008264:Macrophages / Q000473:pathology; D004676:Myelin Basic Protein / Q000494:pharmacology; D009186:Myelin Sheath / Q000737:chemistry; D037121:Plant Lectins; D051381:Rats; D011917:Rats, Inbred Lew; D013116:Spinal Cord / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000637:transplantation
D000941:Antigens; D001323:Autoantibodies; D002352:Carrier Proteins; D006023:Glycoproteins; D037102:Lectins; D004676:Myelin Basic Protein; D037121:Plant Lectins; C033619:lentil lectin