Concentration of some proteinase inhibitors: alpha 1-antitrypsin and alpha 2-macroglobulin in rabbit blood serum in two models of experimental atherosclerosis.
In rabbits with experimental atherosclerosis induced by a cholesterol-rich diet, alpha 1-antitrypsin concentration was decreased as compared with control, by 34%, whereas alpha 2-macroglobulin concentration was increased by 86%. In animals fed a methionine-rich diet changes in concentration of both inhibitors involved in elastase metabolism were but slight, if any.
Grabowska-Bochenek
R
R
Chair of Biochemistry and Chemistry, Silesian Medical Academy, Katowice, Poland.
Drózdz
M
M
Kopieczna-Grzebieniak
E
E
Piekarski
M
M
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D008297:Male; D008715:Methionine / Q000494:pharmacology; D011480:Protease Inhibitors / Q000097:blood*; D011817:Rabbits; D012016:Reference Values; D000515:alpha 1-Antitrypsin / Q000032:analysis*; D000511:alpha-Macroglobulins / Q000032:analysis*
D002791:Cholesterol, Dietary; D011480:Protease Inhibitors; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D008715:Methionine