Cloning and sequence analysis of a human type A/B hnRNP protein.
A cDNA encoding a 284 residue long type A/B hnRNP protein has been cloned. This protein, previously referred to as type C [(1987) J. Biol. Chem. 262, 17126-17137], is an RNA unwinding protein from HeLa 40S hnRNP with a high affinity for G- followed by U-rich sequences. The N-terminal part of the protein contains two consensus RNA binding domains present in a number of other RNA binding proteins. The C-terminal part is glycine-rich and contains a potential ATP/GTP binding loop. The distribution of charged amino acids is highly uneven and there are multiple potential phosphorylation sites.
Khan
F A
FA
Department of Biochemistry, New York University School of Medicine, NY 10016.
Jaiswal
A K
AK
Szer
W
W
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D006367:HeLa Cells; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D008969:Molecular Sequence Data; D012313:RNA / Q000378:metabolism; D012261:Ribonucleoproteins / Q000235:genetics*
D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012261:Ribonucleoproteins; D012313:RNA; D004247:DNA