Specific opiate effects on dextran-induced inflammation in rats.
The effects of opiates were investigated in two models of acute inflammation in rats. Morphine (0.1-10 mg/kg, i.p.) inhibited by 50% the paw edema induced by interdigital injection of 1% dextran solution. Low but not high doses of naltrexone produced a similar degree of inhibition. Naltrexone (10 mg/kg, i.p.) completely prevented morphine antiedema effect. Local anesthesia of the hindleg with lidocaine neither modified dextran-induced paw edema nor morphine inhibitory effects. Morphine (10 mg/kg, i.p.) enhanced by 50% skin vascular permeability induced by intradermically injected 1% dextran solution. Again, naltrexone prevented morphine effects. The obtained results suggest a specific modulatory role of opiates in the acute inflammatory responses of the rat.
Zeitune
M G
MG
Cátedra de Farmacología, Facultad de Odontología, UBA, Argentina.
Bazerque
E
E
Bazerque
P M
PM
D000208:Acute Disease; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D009294:Narcotics / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D003911:Dextrans; D009294:Narcotics