title: Safety and immunogenicity of acellular diphtheria-tetanus-pertussis and Haemophilus conjugate vaccines given in combination or at separate injection sites.
abstract: This prospective, double-blind, randomized trial compared the immunogenicity and reactogenicity of acellular diphtheria-tetanus-pertussis vaccine and Haemophilus influenzae type b conjugate vaccine-diphtheria toxoid conjugate, given at separate injection sites or at a single site, in 79 children 18 months of age who had received three prior immunizing doses of whole-cell diphtheria-tetanus-pertussis vaccine. No significant differences were observed.
authors.affiliation: University of Pittsburgh School of Medicine, Pennsylvania.
authors.forename: A
authors.initials: A
authors.lastname: Kovel
authors.forename: E R
authors.initials: ER
authors.lastname: Wald
authors.forename: N
authors.initials: N
authors.lastname: Guerra
authors.forename: C
authors.initials: C
authors.lastname: Serdy
authors.forename: C K
authors.initials: CK
authors.lastname: Meschievitz
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000009:adverse effects; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D004338:Drug Combinations; D005334:Fever / Q000209:etiology; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D007508:Irritable Mood; D010919:Placebos; D011446:Prospective Studies; D012449:Safety
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004168:Diphtheria Toxoid; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D004338:Drug Combinations; D010919:Placebos