Beta-human chorionic gonadotropin-positive extragonadal germ cell neoplasia of the renal pelvis.
A 56-year-old woman showed renal obstruction on the right side. Further examinations revealed a tumor of the renal pelvis. Nephroureterectomy on the right side was done. This extragonadal germ cell neoplasia had an immunohistochemically detected beta-human chorionic gonadotropin (beta-hCG) expression. There were no other primary tumors or metastases. Although there were normal values after the operation, during the postoperative follow-up, the serum beta-hCG temporarily reached 2400 IU/l and then dropped to normal without detection of metastases. No further therapy was given. The patient was alive and well 1 year and 10 months after surgery. To the authors' knowledge, this is the first extragonadal germ cell neoplasia of the renal pelvis with secretion of beta-hCG to the serum.
Vahlensieck
W
W
Department of Urology, University of Freiburg, Germany.
Riede
U
U
Wimmer
B
B
Ihling
C
C
D014408:Biomarkers, Tumor / Q000032:analysis; D006063:Chorionic Gonadotropin / Q000032:analysis*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry*; D007682:Kidney Pelvis; D008875:Middle Aged; D009373:Neoplasms, Germ Cell and Embryonal / Q000737:chemistry*; D010446:Peptide Fragments / Q000032:analysis*; D014516:Ureteral Neoplasms / Q000737:chemistry*
D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments