[Expression of CD56 antigen on acute nonlymphocytic leukemia].
CD56 antigen (detected by NKH-1) is distributed on NK cells, monocytes, and ectodermal neural cells. In this study, the blasts of 29.2% of 27 patients with acute nonlymphocytic leukemia (ANLL) expressed CD56 antigen, but not CD16, CD2, or CD3 antigen. Leukemic cells isolated from 3 patients with CD56-positive ANLL did not have NK activity. There were no significant differences between CD56-positive and CD56-negative ANLL in CD13-positive cases, CD33-positive cases, and HLA-DR-positive cases. These results suggest that CD56-positive ANLL could be so-called mixed-lineage leukemia (lymphoid-associated antigen in ANLL).
Yamane
T
T
Department of Laboratory Medicine, Osaka City University Medical School.
Inoue
T
T
Furukawa
Y
Y
Yasui
Y
Y
Ota
K
K
Nakao
Y
Y
Ohira
H
H
Tanaka
K
K
Hasuike
T
T
Hirai
M
M
D015703:Antigens, CD / Q000378:metabolism*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000378:metabolism*; D019002:CD56 Antigen; D005434:Flow Cytometry; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D019002:CD56 Antigen