The effect of immunostimulatory drugs on sulfhydryl compounds in plasma, liver and brain after ethanol-induced liver injury in rats.
Sulfhydryl compounds in plasma, liver and brain of rats treated with two immunostimulant drugs, isoprinosine and levamisole, after alcoholic liver injury have been investigated. After use of both drugs for 6 days we found partially beneficial effect on the SH-groups in plasma and liver. No changes in nonprotein SH compounds were observed in rat brain after treatment with isoprinosine, levamisole or ethanol. Furthermore, levamisole shortens the time necessary for the return of AlAT activity to normal value.
Chwiecko
M
M
Department of Inorganic and Analytical Chemistry, Medical Academy, Bialystok, Poland.
Holownia
A
A
Pawlowska
D
D
Farbiszewski
R
R
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D007542:Inosine Pranobex / Q000494:pharmacology* / Q000627:therapeutic use; D007978:Levamisole / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000097:blood / Q000378:metabolism*
D013438:Sulfhydryl Compounds; D007978:Levamisole; D007542:Inosine Pranobex