[The possibility of the restoration of interferon formation by biologically active thymus factors in experimentally induced immunodepression].
Interferon production was investigated in mice of CBA line with experimentally induced immunosuppression. With all types of treatment (irradiation, administration of hydrocortisone, cyclophosphane, ALS) the capacity of host cells for interferon production was shown to be reduced. Administration of biologically active thymus factor, thymostimulin, to experimental animals resulted in significant restoration of alpha/beta and gamma interferon production.
Chernenko
O D
OD
Grinevich
Iu A
IuA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000188:drug therapy*; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000097:blood; D051379:Mice; D008808:Mice, Inbred CBA; D013949:Thymus Extracts / Q000627:therapeutic use*; D013997:Time Factors
D000276:Adjuvants, Immunologic; D007369:Interferon Inducers; D013949:Thymus Extracts; C031407:thymostimulin; D007372:Interferons
Vozmozhnost' vosstanovleniia interferonoobrazovaniia biologicheski aktivnymi faktorami timusa v usloviiakh éksperimental'no vyzvannoĭ immunodepressii.