title: Whipple's disease confined to the CNS presenting with multiple intracerebral mass lesions.
abstract: A patient with isolated cerebral Whipple's disease presented with signs of raised intracranial pressure and multiple ring enhancing intracerebral mass lesions evident on CT and MRI imaging. Characteristic intracellular bacilliform inclusions were identified in a brain biopsy. Clinical improvement followed treatment with parenteral antibiotics for two weeks and long term sulphamethoxazole-trimethoprim. As CNS relapse of Whipple's disease may occur after several years, long term treatment should include antibiotics that are able to cross the blood-brain barrier.
authors.affiliation: National Hospital, London, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wroe
authors.forename: M
authors.initials: M
authors.lastname: Pires
authors.forename: B
authors.initials: B
authors.lastname: Harding
authors.forename: B D
authors.initials: BD
authors.lastname: Youl
authors.forename: S
authors.initials: S
authors.lastname: Shorvon
mesh_terms: D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007427:Intracranial Pressure; D008279:Magnetic Resonance Imaging; D008297:Male; D008061:Whipple Disease / Q000473:pathology* / Q000503:physiopathology