Anti-allergic effect of N-acetylneuraminic acid in guinea-pigs.
The in-vivo anti-allergic effect of N-acetylneuraminic acid (NANA) in guinea-pigs passively sensitized with anti-ovalbumin rabbit serum has been studied. NANA (20 mg kg-1 i.v.) inhibited bronchial anaphylaxis and the release of histamine into bronchoalveolar lavage fluid. NANA dose-dependently inhibited heterologous passive cutaneous anaphylaxis and haemorrhaging in the passive Arthus reaction. However, it did not inhibit the release of histamine from sensitized minced lung tissue.
Kai
H
H
Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Murata
Y
Y
Ishii
T
T
Nishijima
S
S
Murahara
K
K
Ogasawara
S
S
Sugiyama
N
N
Takahama
K
K
Miyata
T
T
D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D019158:N-Acetylneuraminic Acid; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D012794:Sialic Acids / Q000627:therapeutic use*
D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid