Analysis of suppressor activity in experimental allergic encephalomyelitis inhibited by graft-versus-host reaction.
The induction of local graft-versus-host reaction (GvH) prior to the encephalitogenic challenge resulted in the conversion of acute experimental allergic encephalomyelitis (EAE) to the chronic-like EAE. This inhibitory effect of GvH on EAE development was cyclophosphamide (CY) sensitive. Cell-free supernatants of peripheral blood lymphocytes (PBL) isolated from guinea pigs with chronic-like EAE and during recovery from EAE showed suppressor activity on the in vitro proliferative response of myelin basic protein (MBP) sensitized PBL. The appearance of anaphylactic anti-MBP antibodies and a change in the ratio complement fixing: haemagglutinating (CF/HA) antibodies was also registered.
Staykova
M
M
Institute of Cell Biology and Morphology, Sofia, Bulgaria.
Kozovska
M
M
Nikolova
E
E
Goranov
I
I
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006087:Graft vs Host Reaction / Q000187:drug effects / Q000276:immunology*; D006168:Guinea Pigs; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D013491:Suppressor Factors, Immunologic / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*
D001323:Autoantibodies; D004676:Myelin Basic Protein; D013491:Suppressor Factors, Immunologic; D003520:Cyclophosphamide