title: Comparative effects of cyclosporine A and FK-506 on endothelin secretion by a cultured renal cell line, LLC-PK1.
abstract: Cyclosporine A (CSA) stimulated endothelin secretion by a cultured renal epithelial cell line, LLC-PK1. A less nephrotoxic immunosuppressant (FK-506) did not affect endothelin secretion. Putative endothelin converting enzyme inhibitors or specific receptor antagonists may therefore prevent CSA nephrotoxicity.
authors.affiliation: First Department of Medicine, Osaka University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakahama
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
authors.forename: M
authors.initials: M
authors.lastname: Kakihara
authors.forename: M
authors.initials: M
authors.lastname: Horio
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuhara
authors.forename: N
authors.initials: N
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Orita
authors.forename: T
authors.initials: T
authors.lastname: Kamada
mesh_terms: D002460:Cell Line; D016572:Cyclosporine / Q000494:pharmacology*; D016232:Endothelins / Q000378:metabolism*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D016559:Tacrolimus / Q000494:pharmacology*
chemical_list: D016232:Endothelins; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus