title: [Diagnostic usefulness and prognostic value of inhibitory capacity and other biochemical parameters of plasma in acute pancreatitis in humans].
abstract: Assessment of the degree of severity of acute pancreatitis by means of biochemical parameters is still a subject of extensive studies. The purpose of the present study was a trial of evaluation of the diagnostic usefulness and prognostic value of certain tests for proteinase-anti-proteinase equilibrium and acute phase indices in acute pancreatitis in 52 patients (36 women and 16 men aged 22 to 83 years). The control group compared 29 healthy volunteers. The patients were classified according to the aetiology of the disease: pancreatitis connected with bile duct disease, alcoholic and non-classifiable, and another classification was based on the clinical course (medium severe, severe). Significantly higher concentration of immunoreactive trypsin (TLI) was found in the first two weeks in the group of severe disease as compared to the group with medium severe pancreatitis (p less than 0.01). TLI was significantly higher than in controls for 2 months after clinical recovery. The serum inhibitory capacity was significantly reduced in severe cases in relation to medium severe ones, particularly between 3 and 7 days of the disease (p less than 0.001). Similarly as trypsin concentration, reduced inhibitory capacity in relation to controls persisted for up to 2 months after pancreatitis. No significant differences were noted in the concentration of alpha 1 protease inhibitor and C3 and C4 complement components, in the studied groups. The serum alpha 2 macroglobulin level was significantly decreased between days 3 and 7 (p less than 0.05). The values of alpha 2 macroglobulin were correlated in that time with the values of the inhibitory capacity.
authors.affiliation: Kliniki Gastroenterologii AM w Białymstoku.
authors.forename: G
authors.initials: G
authors.lastname: Rydzewska
authors.forename: A
authors.initials: A
authors.lastname: Gabryelewicz
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000175:diagnosis*; D011379:Prognosis; D012720:Severity of Illness Index; D014357:Trypsin / Q000097:blood; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D000511:alpha-Macroglobulins; D014357:Trypsin
vernacular_title: Przydatność diagnostyczna i prognostyczna oznaczania pojemności inhibitorowej oraz innych wybranych parametrów biochemicznych osocza w ostrym zapaleniu trzustki u ludzi.