Modelling of protein adsorption on polymeric surfaces.
A new method of calculation of protein adsorption on polymeric surfaces is presented. The method considers the thermodynamic equilibrium of a three-component system--water, protein, and polymer surface--and describes the protein concentration profile based on the interaction energy parameters for protein-polymer, water-polymer, and protein-water contacts. Calculation of these parameters calls for introduction of the energies arising from the dispersive forces, the hydrophobic effect, and the Drago et al. (1971) electron donor-acceptor interactions. Comparison with experimental results of protein adsorption on various polymeric surfaces gave satisfactory agreement.
van Straaten
J
J
School of Chemical Engineering, Purdue University, West Lafayette, IN 47907.
Peppas
N A
NA
D000327:Adsorption; D005340:Fibrinogen / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008433:Mathematics; D008956:Models, Chemical; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013499:Surface Properties; D014867:Water / Q000737:chemistry; D005719:gamma-Globulins / Q000737:chemistry
D011108:Polymers; D011506:Proteins; D005719:gamma-Globulins; D014867:Water; D012710:Serum Albumin, Bovine; D005340:Fibrinogen