Physico-chemical properties of the new antibronchospastic agent isbufylline.
Physico-chemical properties, i.e. elemental analysis, spectra (NMR, MS, IR, UV), X-ray crystal structure, solubilities, partition coefficient, melting point, HPLC, GC, and data about purity and stability of 1,3-dimethyl-7-isobutyl xanthine (isbufylline, TE/06, CAS 90162-60-0), a new drug with antibronchospastic properties, are reported.
Agostini
O
O
Istituto Farmacobiologico Malesci S.p.A., Research Laboratories, Florence, Italy.
Bonacchi
G
G
Dapporto
P
P
Paoli
P
P
Fedi
M
M
Manzini
S
S
D015056:1-Methyl-3-isobutylxanthine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000138:chemical synthesis / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D011208:Powders; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
D001993:Bronchodilator Agents; D011208:Powders; C058878:isbufylline; D015056:1-Methyl-3-isobutylxanthine