The distribution and half-life for retention of vanadium in the organs of normal and diabetic rats orally fed vanadium(IV) and vanadium(V).
The concentration of vanadium in organs of diabetic rats that had been fed vanadium, either as V(IV) or V(V), in their drinking water has been determined. The kidney was found to have the highest concentration, about 185 nmol/g wet tissue. This averages about three times higher than for the liver or spleen, for which concentrations were comparable. The lung, blood plasma, and blood cells tended to have the lowest accumulations of vanadium. A time-course study indicated that the half-life for elimination of vanadium from the bodies of vanadium-fed rats is about 12 d.
Ramanadham
S
S
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Heyliger
C
C
Gresser
M J
MJ
Tracey
A S
AS
McNeill
J H
JH
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006207:Half-Life; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014639:Vanadium / Q000737:chemistry / Q000493:pharmacokinetics*
D014639:Vanadium