title: Enalaprilat versus cilazaprilat: a comparison of allergic skin reactions in the guinea pig.
abstract: ACE-inhibitors have for some time been used in the treatment of hypertension. Apart from inhibiting the conversion of angiotensin I to II, the drugs also affect the metabolism of some inflammatory agents, like bradykinin and substance P. Egg albumin (EA)-sensitized guinea pigs were pretreated with the ACE-inhibitors. Measurement of flare and wheal areas induced by an intradermal injection of EA, showed that enalaprilat significantly increased, whereas cilazaprilat slightly decreased, the reaction area. Enalaprilat also showed an enhancement in histamine and substance P (SP) contents in the skin. In vitro incubation of guinea pig biopsies with enalaprilat potentiated EA- but not SP-induced histamine release. The EA-induced effect was abolished if the animals were pretreated with capsaicin. The conclusion is that cilazaprilat, in contrast to enalaprilat, does not potentiate inflammatory reactions in the guinea pig.
authors.affiliation: Dept. of Pharmacology, University of Linköping, Sweden.
authors.forename: K M
authors.initials: KM
authors.lastname: Persson
authors.forename: R G
authors.initials: RG
authors.lastname: Andersson
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D000941:Antigens / Q000276:immunology; D017315:Cilazapril / Q000031:analogs & derivatives*; D003872:Dermatitis / Q000276:immunology*; D015773:Enalaprilat / Q000494:pharmacology / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D006967:Hypersensitivity / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D011724:Pyridazines / Q000494:pharmacology / Q000633:toxicity*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000941:Antigens; D011724:Pyridazines; D017315:Cilazapril; D010047:Ovalbumin; D015773:Enalaprilat; C045980:cilazaprilat