title: SIV of stump-tailed macaque (SIVstm) is a divergent Asian isolate.
abstract: Analysis of molecularly cloned DNAs of SIVs isolated from Asian rhesus macaque (Macaca mulatta; SIVmac) and pig-tailed macaque (Macaca nemestrina; SIVmne) has indicated a high degree of sequence homology between these viruses. Thus SIVmac and SIVmne might have originated from the same or very closely related viruses. We have cloned and sequenced a PCR-amplified segment containing the LTR sequences of SIV originating from a stump-tailed macaque (Macaca arctoides; SIVstm). Comparative sequence analysis indicates that SIVstm belongs to the SIV/HIV-2 group; however, it is genetically distinct from the other members.
authors.affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
authors.forename: A S
authors.initials: AS
authors.lastname: Khan
authors.forename: T A
authors.initials: TA
authors.lastname: Galvin
authors.forename: M B
authors.initials: MB
authors.lastname: Jennings
authors.forename: M B
authors.initials: MB
authors.lastname: Gardner
authors.forename: L J
authors.initials: LJ
authors.lastname: Lowenstine
mesh_terms: D000818:Animals; D001208:Asia; D001483:Base Sequence; D002460:Cell Line; D004279:DNA, Viral / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D008251:Macaca / Q000382:microbiology*; D008253:Macaca mulatta / Q000382:microbiology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012091:Repetitive Sequences, Nucleic Acid; D012689:Sequence Homology, Nucleic Acid; D016097:Simian Acquired Immunodeficiency Syndrome / Q000382:microbiology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000235:genetics / Q000502:physiology; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D012194:RNA-Directed DNA Polymerase