title: Proteoglycan epitope in synovial fluid in gonarthrosis. 28 cases of tibial osteotomy studied prospectively for 2 years.
abstract: High tibial osteotomy was performed for medial gonarthrosis in 28 patients. Preoperatively, and at 3, 12, and 24 months after surgery, clinical and radiographic examinations were made, and joint-fluid samples were aspirated. Arthroscopy was performed preoperatively and at 24 months. Immunoassay of proteoglycan epitope in joint fluid showed an increase in concentration at all times as compared with a reference population with normal knee joints. An increase in both the concentration and the total amount of proteoglycan epitope in joint fluid was noted at 3 months postoperatively with a return to preoperative values at later times. Regrowth of fibrocartilage did not correlate with proteoglycan epitope data.
authors.affiliation: Lund University Hospital, Department of Orthopedics, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Odenbring
authors.forename: N
authors.initials: N
authors.lastname: Egund
authors.forename: A
authors.initials: A
authors.lastname: Lindstrand
authors.forename: L S
authors.initials: LS
authors.lastname: Lohmander
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000601:surgery; D000939:Epitopes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010027:Osteotomy; D011446:Prospective Studies; D011509:Proteoglycans / Q000378:metabolism*; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D000939:Epitopes; D011509:Proteoglycans