[Important laboratory parameters of deep frozen coagulation active fresh plasma and virus inactivated lyophilized pool plasma].
Fresh Frozen Plasma is the most important therapeutic agent in acquired coagulation disorders. We investigated the quality of a new virus-inactivated lyophilisated human pool-plasma (VFL) and conventional fresh frozen plasma (FFP). In VFL we found a significantly reduced coagulation activity, a significantly higher pH-value, a highly significant rise of heparin values and a significantly lower number of thrombocytes. Electrolytes, protein levels and complement activity showed no significant difference. In conclusion, this virus-inactivated lyophilisated human pool plasma does not seem to be susceptible to therapy coagulation disorders like the conventional fresh frozen plasma.
Hügler
P
P
Klinik für Anästhesiologie, Ruhruniversität Bochum am St. Josef-Hospital.
Möller
J H
JH
Neumann
H
H
Sirtl
C
C
Laubenthal
H
H
D000998:Antiviral Agents / Q000494:pharmacology*; D001771:Blood Banks; D001779:Blood Coagulation Factors / Q000032:analysis*; D001780:Blood Coagulation Tests; D003902:Detergents / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010949:Plasma / Q000737:chemistry* / Q000382:microbiology; D012997:Solvents / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects*
D000998:Antiviral Agents; D001779:Blood Coagulation Factors; D003902:Detergents; D012997:Solvents
Wichtige Laborparameter bei tiefgefrorenen gerinnungsaktiven Frischplasmen und virusinaktivierten lyophilisierten Poolplasmen.