Critical micelle concentration and hemolytic activity--a correlation suggested by the marine sterol, halistanol trisulfate.
The marine natural product, halistanol trisulfate, has a relatively low critical micelle concentration of 0.001% m/v (14.5 microM) and strong hemolytic potency with an EC50 of 0.00046% m/v (6.67 microM). As expected of a detergent, it inhibits the growth of gram-positive but not gram-negative bacteria. The hemolytic activity of halistanol trisulfate and other detergents has been shown to correlate with critical micelle concentration. This correlation may have important implications in the mechanism of membranolytic bioactivity.
Moni
R W
RW
School of Science, Griffith University, Brisbane, Queensland, Australia.
Parsons
P G
PG
Quinn
R J
RJ
Willis
R J
RJ
D000818:Animals; D001409:Bacillus cereus / Q000187:drug effects; D003840:Deoxycholic Acid / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008823:Micelles; D008826:Microbial Sensitivity Tests; D017830:Octoxynol; D011092:Polyethylene Glycols / Q000494:pharmacology; D011161:Porifera; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013261:Sterols / Q000302:isolation & purification / Q000494:pharmacology*
D003902:Detergents; D008823:Micelles; D013261:Sterols; D003840:Deoxycholic Acid; C072244:halistanol trisulfate; D011092:Polyethylene Glycols; D017830:Octoxynol