Virus-host cell interactions in human immunodeficiency virus infections.
The isolate HTLV-IIIB is used by a large number of investigators for a variety of studies. The data shown here emphasize the uniqueness of this isolate with respect to certain biological behaviors, in particular, the ability to infect cells other than T lymphocytes and mononuclear phagocytes, and the ability to infect chimpanzee T cells. Data also presented indicates that HTLV-IIIB has a greater binding affinity for the CD4 receptor molecule, which may help to explain its observed biological uniqueness. Caution in generalizing from findings based on studies with HTLV-IIIB alone is recommended. In addition, evidence demonstrating CD4-mediated entry of HIV-1 into normal human monocyte/macrophages is included.
Gartner
S
S
Primate Research Institute, New Mexico State University, Holloman AFB 88330.
Ohashi
K
K
Popovic
M
M
D000818:Animals; D001665:Binding Sites; D015704:CD4 Antigens / Q000378:metabolism*; D004198:Disease Susceptibility; D000939:Epitopes; D015658:HIV Infections / Q000382:microbiology*; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000382:microbiology*; D008264:Macrophages / Q000382:microbiology; D009000:Monocytes / Q000382:microbiology; D002679:Pan troglodytes / Q000382:microbiology; D010586:Phagocytes / Q000382:microbiology
D015704:CD4 Antigens; D000939:Epitopes