Inhibition by calcitonin gene-related peptide of agonist-induced bronchoconstriction in various mammals including man.
The effect of calcitonin gene-related peptide (CGRP) on the smooth muscle of mammalian airways has been investigated in vitro. CGRP itself lacked contractile activity but reduced responses evoked by bronchoconstrictor agents via a post-junctional action. The inhibitory effect of CGRP was concentration-related and greatest in distal airways. The results suggest that CGRP may contribute to regulating muscular tone in the tracheobronchial tree.
Cadieux
A
A
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.
Lanoue
C
C
D000818:Animals; D001980:Bronchi / Q000187:drug effects; D016084:Bronchoconstriction / Q000187:drug effects*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013373:Substance P / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D012702:Serotonin Antagonists; D012701:Serotonin; D013373:Substance P; D002217:Carbachol; D015740:Calcitonin Gene-Related Peptide