Chromium-cage complex as contrast agent in MR imaging--biodistribution studies of the [57Co]cobalt analogue.
The synthesis and T1 and T2 relaxivities of the Cr(III)-(NH2)-Sar-cage complex is reported. An outer-sphere relaxation mechanism is postulated for the relaxivity of the complex. Tissue distribution studies in mice using a [57Co]cobalt analogue as a radioactive tracer showed that the complex is excreted rapidly in the urine. Some renal uptake of the complex is seen. Appreciable uptake of labelled cage complex was observed in 3-methylcholanthrene induced murine rhabdomyosarcoma.
Jackson
G E
GE
Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
Byrne
M J
MJ
Blekkenhorst
G
G
Hendry
A J
AJ
D000818:Animals; D003035:Cobalt / Q000737:chemistry / Q000493:pharmacokinetics*; D003037:Cobalt Radioisotopes; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging; D012521:Sarcosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D014018:Tissue Distribution
D003037:Cobalt Radioisotopes; D003287:Contrast Media; D006571:Heterocyclic Compounds; D003035:Cobalt; C059143:diamsar chelate; D012521:Sarcosine