[A case of RAEB-t treated by G-CSF showing complete remission after MST-16 treatment for subsequent reversible leukemia].
A seventy-five-year-old female with general fatigue, high fever and anemia was admitted. Her chest X-ray film revealed pneumonia. She was diagnosed as RAEB-t with the normal karyotype by peripheral blood film and bone marrow aspiration; 125 micrograms/ml of G-CSF was administered s.c. daily in order to increase neutrophil count because of the prolongation of pneumonia. Her blast cells in both peripheral blood and bone marrow showed a remarkable increase by G-CSF. After the cessation of G-CSF administration, blast cells decreased rapidly, and neutrophil count in the peripheral blood increased. Her pneumonia was then cured. After 5 months of stable hematological state, 60% of her bone marrow cells became occupied by blast cells again. So 2 consecutive courses of 14 days p.o. administration of 1,200 mg MST-16/day were tried. Three months after the first MST-16 trial, her bone marrow showed complete remission (CR) which lasted about 4 months. But she died of sepsis after the first relapse. Her bone marrow in CR still revealed several features of dyspoiesis.
Murate
T
T
First Dept. of Internal Medicine, Nagoya University School of Medicine, Japan.
Ohashi
H
H
Kagami
Y
Y
Hotta
T
T
Murase
T
T
Hirota
Y
Y
Kimura
K
K
D000208:Acute Disease; D000284:Administration, Oral; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000473:pathology / Q000628:therapy*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology; D002999:Clone Cells; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D007958:Leukocyte Count; D009504:Neutrophils; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D012074:Remission Induction
D000970:Antineoplastic Agents; D010879:Piperazines; D016179:Granulocyte Colony-Stimulating Factor; C057773:sobuzoxane