[Establishment of cell lines of human germinal tumors].
Human germinal tumor cells have been studied in cancer research because of their characteristics of the multi-potentiality and the ability to produce marker proteins such as AFP and SP1. Although human germinal tumor cell colonies had usually been maintained by serial transplantation into nude mice, we established in vitro culture method of cells derived from human malignant germ cell tumors. Thirty-two cell lines were established in vitro, and AFP and SP1 produced in culture medium of those cell line were demonstrated immunochemically.
Fujino
H
H
Katayama Chemical Industries, LTD, Osaka.
Watabe
H
H
D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002455:Cell Division; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000096:biosynthesis; D013724:Teratoma / Q000378:metabolism / Q000473:pathology*; D013736:Testicular Neoplasms / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured; D000509:alpha-Fetoproteins / Q000096:biosynthesis
D014408:Biomarkers, Tumor; D011268:Pregnancy-Specific beta 1-Glycoproteins; D000509:alpha-Fetoproteins