Microemulsions as topical drug delivery vehicles: in-vitro transdermal studies of a model hydrophilic drug.
Microemulsions with a 58:42 weight ratio of dioctyl sodium sulphosuccinate: octanol and containing 15, 35, and 68% water have been tested for their ability to transport glucose across human cadaver skin. A flow-through multisample skin diffusion cell showed that both the 35 and 68% water microemulsions caused enhanced (approximately 30-fold) transport of glucose. No transport was discernible for the 15% water microemulsion. Differences in percutaneous glucose transport were shown to parallel differences in the diffusion of water within the microemulsion vehicles before application to the skin.
Osborne
D W
DW
Drug Delivery R&D--Specialty Products, Upjohn Company, Kalamazoo, MI 49001-0199.
Ward
A J
AJ
O'Neill
K J
KJ
D000279:Administration, Cutaneous; D000287:Administration, Topical; D004058:Diffusion; D004143:Dioctyl Sulfosuccinic Acid / Q000493:pharmacokinetics*; D004655:Emulsions; D005947:Glucose / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption
D004655:Emulsions; D014677:Pharmaceutical Vehicles; D004143:Dioctyl Sulfosuccinic Acid; D005947:Glucose