title: Hyaline globules reacting positively with zidovudine antibody in brain and spinal cord of AIDS patients.
abstract: Histology of the central nervous system in nine AIDS showed extracellular hyaline globules in the white matter of the brain and the spinal cord. In immunohistochemical studies with a battery of antibodies, the only positive reaction of these globules was with an antibody to zidovudine. High-performance liquid chromatography showed the presence of a zidovudine isomer in eluates of brain tissue from these patients.
authors.affiliation: Institute of Pathology, Auguste-Victoria-Krankenhaus, Berlin, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Artigas
authors.forename: K
authors.initials: K
authors.lastname: Arastéh
authors.forename: R
authors.initials: R
authors.lastname: Averdunk
authors.forename: B
authors.initials: B
authors.lastname: Bachler
authors.forename: M
authors.initials: M
authors.lastname: Hornscheidt
authors.forename: G
authors.initials: G
authors.lastname: Grosse
authors.forename: M
authors.initials: M
authors.lastname: L'age
authors.forename: F
authors.initials: F
authors.lastname: Niedobitek
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D001923:Brain Chemistry; D005110:Extracellular Space; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D013116:Spinal Cord / Q000737:chemistry*; D013194:Staining and Labeling; D015215:Zidovudine / Q000032:analysis / Q000276:immunology*
chemical_list: D000906:Antibodies; D015215:Zidovudine