Effects of cocaine on oxygen consumption and mitochondrial respiration in normoxic and hypoxic mice.
The administration of cocaine hydrochloride intraperitoneally (25 mg/kg) produces a drop in VO2 in both normoxic and hypoxic mice. The critical PO2 is also decreased and so is the body temperature. The mitochondrial respiration shows a large fall in ST3 and RCR. The addition of cocaine in-vitro to the incubating medium induces changes in the mitochondrial respiration similar to those found after in-vivo administration. This report shows that in addition to its in-vivo actions cocaine alters the respiratory function of the isolated liver mitochondria.
León-Velarde
F
F
Depto. de Ciencias Fisiológicas, Universidad Peruana Cayetano Heredia, Lima, Perú.
Huicho
L
L
Monge
C
C
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008839:Microelectrodes; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D012119:Respiration
D003042:Cocaine