Cerebrospinal fluid anti-cerebellar soluble lectin antibodies in human immunodeficiency virus type 1 infection.
Cerebrospinal fluid samples from 14 human immunodeficiency type 1 (HIV-1) seropositive patients in various stages of HIV infection were tested for the presence of autoantibodies to an endogenous manose-binding protein, the cerebellar soluble lectin (CSL), which has recently been found to be detected in a high proportion of patients with multiple sclerosis. An immunoblotting test was used with rat CSL as antigen. Seven patients were positive for anti-CSL and seven were negative. The seven anti-CSL-positive patients had signs of intrathecal immunoglobulin G production measured as an elevated IgG index, while the seven anti-CSL-negative patients had a normal IgG index. There was no apparent relation between infectious stage and the presence of anti-CSL. Immunological reactions such as anti-CSL autoantibodies may be a similar pathogenic mechanism in HIV and multiple sclerosis brain disease.
Hagberg
L
L
Department of Infectious Diseases, University of Göteborg, Sweden.
Norkrans
G
G
Zanetta
J P
JP
Lehmann
S
S
Bergström
T
T
D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000276:immunology*; D000328:Adult; D001323:Autoantibodies / Q000134:cerebrospinal fluid*; D002531:Cerebellum / Q000276:immunology*; D005260:Female; D015497:HIV-1; D006801:Humans; D037102:Lectins / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D037102:Lectins