Hepatoid carcinoma of the ovary: a case report.
A case of a right ovarian tumor in a 64-year-old patient showing high blood levels of alpha-fetoprotein (AFP) is reported. Histologically, the tumor resembled hepatocellular carcinoma with hyaline globules. Localization of AFP was detected by the immunoperoxidase method. Electron microscopically, the rough-surfaced endoplasmic reticulum had developed into a meshwork, and the mitochondria were present within this meshwork. Because a transition from adenocarcinoma to a region resembling hepatocellular carcinoma was observed, this tumor was considered to originate as a common epithelial carcinoma. In the blood, 67% of the AFP was bound with concanavalin A (Con A), and the fraction pattern obtained by lentil agglutinin affinity chromatography (LCA) was of the germ cell type. From these results, the current case may be labeled clinicopathologically a hepatoid carcinoma of the ovary as described by Ishikura and Scully.
Matsuta
M
M
Department of Obstetrics and Gynecology, School of Medicine, Iwate Medical University, Morioka, Japan.
Ishikura
H
H
Murakami
K
K
Kagabu
T
T
Nishiya
I
I
D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins