Lesions of nucleus basalis alter ChAT activity and EEG in rat frontal neocortex.
The EEG was recorded from frontal, parietal and visual cortices of sham-operated control rats and rats having ibotenic acid lesions of the nucleus basalis. Recordings were made during a period of rest and during stimulus-evoked desynchronization. Spectral power was determined using a Fast Fourier Transform routine; 3 artifact-free 4 sec epochs of resting activity and two 4 sec epochs of activated EEG were analyzed. Choline acetyltransferase activity (ChAT) was measured in each cortical area and was reduced in lesioned animals an average of 25% in frontal cortex, 19% in the parietal region and 10% in visual cortex. The percent of low frequency activity (1-12 Hz) in the frontal EEG was significantly greater in lesioned animals than in the control group during quiet rest; a significant correlation was found between ChAT activity and power in this band. Desynchronized activity was largely unaffected except for a reduction in 25-31 Hz activity in the frontal cortex of lesioned animals. EEG activity in both the parietal and visual areas was unchanged from control values.
Ray
P G
PG
Department of Physiology and Endocrinology, Medical College of Georgia, Augusta.
Jackson
W J
WJ
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced*; D002540:Cerebral Cortex / Q000201:enzymology / Q000503:physiopathology*; D002795:Choline O-Acetyltransferase / Q000032:analysis*; D003344:Cortical Synchronization; D004569:Electroencephalography; D005583:Fourier Analysis; D007051:Ibotenic Acid; D008297:Male; D009847:Olivary Nucleus / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D007051:Ibotenic Acid; D002795:Choline O-Acetyltransferase