Interleukin-6 stimulates proliferation of cultured vascular smooth muscle cells independently of interleukin-1 beta.
The effects of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) on proliferation of cultured vascular smooth muscle cells (VSMCs) were investigated. Treatment with IL-6 caused a rapid increase in the c-myc mRNA level, and resulted in increases in DNA synthesis and cell number. IL-1 beta stimulated the DNA synthesis of the cells. EGF showed synergistic and PDGF or IL-1 beta showed additive effects with IL-6 on the DNA synthesis. These results suggest that IL-6, independently of IL-1 beta, may be important in the proliferation of VSMCs.
Morimoto
S
S
Department of Geriatric Medicine, Osaka University Medical School, Japan.
Nabata
T
T
Koh
E
E
Shiraishi
T
T
Fukuo
K
K
Imanaka
S
S
Kitano
S
S
Miyashita
Y
Y
Ogihara
T
T
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007375:Interleukin-1; D015850:Interleukin-6; D004247:DNA