title: Resorption of bone by inflammatory cells derived from the joint capsule of hip arthroplasties.
abstract: The role of inflammatory cells in aseptic loosening and failure of cemented joint replacements is unclear. Inflammatory cells from the revision joint capsule of four failed hip arthroplasties were examined to determine their nature and resorptive capacity. The capsules contained numerous macrophages and abundant foreign-body macrophage polykaryons, distinguished from osteoclasts by their antigenic phenotype and lack of response to calcitonin. When cultured on cortical bone slices in vitro, both macrophages and macrophage polykaryons produced small resorption pits and were associated with areas of superficial resorption of the bone surface. These results indicate that foreign-body induced macrophages and macrophage polykaryons are capable of a type of low-grade bone resorption which may be of pathogenic significance in the loosening of cemented joint prosthetic components.
authors.affiliation: Nuffield Department of Pathology, John Radcliffe Hospital, Oxford, England.
authors.forename: N A
authors.initials: NA
authors.lastname: Athanasou
authors.forename: J
authors.initials: J
authors.lastname: Quinn
authors.forename: C J
authors.initials: CJ
authors.lastname: Bulstrode
mesh_terms: D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis; D001843:Bone Cements / Q000627:therapeutic use; D001862:Bone Resorption / Q000276:immunology / Q000473:pathology*; D002116:Calcitonin / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects / Q000276:immunology / Q000648:ultrastructure; D006621:Hip Joint / Q000276:immunology / Q000473:pathology*; D006622:Hip Prosthesis; D006801:Humans; D007150:Immunohistochemistry; D008855:Microscopy, Electron, Scanning; D010641:Phenotype; D011183:Postoperative Complications / Q000276:immunology / Q000473:pathology*; D011475:Prosthesis Failure; D012086:Reoperation; D013583:Synovial Membrane / Q000187:drug effects / Q000276:immunology / Q000648:ultrastructure
chemical_list: D000911:Antibodies, Monoclonal; D000941:Antigens; D001843:Bone Cements; D002116:Calcitonin