[Monoamine concentration in the cerebrospinal fluid of patients with subarachnoid aneurysm].
Using a spectrofluorometric method, the concentration of the major monoamines, norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-), and 5-hydroxyindoleacetic (5-HIAA) was determined in cerebrospinal fluid (CSF) of patients with subarachnoid aneurysm before its rupture. DA, 5-HT, and 5-HIAA levels in CSF were found significantly increased when compared with the corresponding values found in persons with no clinical alterations of central nervous system (CNS). No significant differences were seen in NE values in CSF when data from patients with subarachnoid aneurysm were compared to their control subjects. Data obtained suggest that of NE diffusion to CSF could be at a different rate than that of the other monoamines measured. Alternatively, the reuptake of NE could vary in relation with that to the other monoamines in the affected brain tissue during the onset and development of the aneurysm. Results may also indicate a possible accumulation of NE in brain tissue adjacent to the damaged areas as a result of an increased monoaminergic activity, which, could be involved in the pathophysiology of aneurysm rupture.
Velázquez
A
A
Divisione de Biología del Desarrollo, Unidad de Inv. Biomédica de Occidente, IMSS, Guadalajara, Jal., México.
Márquez
J
J
Feria-Velasco
A
A
D000328:Adult; D000368:Aged; D001679:Biogenic Amines / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D004298:Dopamine / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D002532:Intracranial Aneurysm / Q000134:cerebrospinal fluid* / Q000150:complications; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D012422:Rupture, Spontaneous; D012701:Serotonin / Q000134:cerebrospinal fluid; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000209:etiology; D013346:Subarachnoid Space
D001679:Biogenic Amines; D015415:Biomarkers; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine
Concentración de monoaminas en líquido cefalorraquídeo de pacientes con aneurisma subaracnoideo.