title: [Immune hematologic diagnosis in women with habitual abortion].
abstract: It has been proposed that unexplained recurrent miscarriages are caused by maternal immune rejection of the semi-allogenic fetus. The problem has been treated by immunization with paternal leukocytes to induce maternal antipaternal-antibodies that may block immune rejection of the fetus. It has been suggested that excessive sharing of HLA antigens predisposes couples to recurrent abortion. However, we did not find evidence for excessive HLA-sharing. The degree of sharing did not differ significantly between the couples with recurrent miscarriages and controls with successful pregnancies.
authors.affiliation: Institut für Immunhämatologie Univ. Frankfurt.
authors.forename: G
authors.initials: G
authors.lastname: Holzberger
authors.forename: S
authors.initials: S
authors.lastname: Seidl
authors.forename: P
authors.initials: P
authors.lastname: Kühnl
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology* / Q000628:therapy; D001666:Binding Sites, Antibody / Q000276:immunology; D001667:Binding, Competitive / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007114:Immunization / Q000379:methods*; D011247:Pregnancy
chemical_list: D006680:HLA Antigens
vernacular_title: Immunhämatologische Diagnostik bei Frauen mit habituellen Aborten.