title: Persistent gestational trophoblastic disease following evacuation of a tetraploid partial hydatidiform mole.
abstract: A 31-year-old woman at 11 weeks gestation with ultrasonographic demonstration of partial mole had markedly elevated serum bHCG levels (458,000 mIU/ml). The patient underwent a vacuum curettage with pathological confirmation of the diagnosis, and cytogenetic analysis revealed a tetraploid karyotype (92,XXXX). The patient developed persistent gestational trophoblastic disease and was successfully treated with two courses of actinomycin D. Persistent trophoblastic disease after evacuation of a tetraploid partial mole was not reported previously.
authors.affiliation: Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
authors.forename: Z
authors.initials: Z
authors.lastname: Appelman
authors.forename: R
authors.initials: R
authors.lastname: Dgani
authors.forename: Y
authors.initials: Y
authors.lastname: Zalel
authors.forename: U
authors.initials: U
authors.lastname: Elchalal
authors.forename: B
authors.initials: B
authors.lastname: Caspi
mesh_terms: D000328:Adult; D003609:Dactinomycin / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006828:Hydatidiform Mole / Q000000981:diagnostic imaging / Q000235:genetics / Q000601:surgery*; D007621:Karyotyping; D011123:Polyploidy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000601:surgery*
chemical_list: D003609:Dactinomycin