[Multivariate analysis for the understanding of typical diabetic hemostasis criteria. 3. Determination of a typical retinopathy parameter-constellation].
Features of metabolism and haemostasis which are different in diabetics of both types in comparison with normal subjects were covered by the statistical method of multivariance analysis depending on the severity of diabetic retinopathy. In 29 diabetics without retinopathy, 46 patients with stage I or II, and 36 patients with stage III the following parameters could be found as optimal criteria for characterizing the extent of vascular changes: blood sugar concentration, concentration of sialic acid and HDL cholesterol in the serum, serum protein, sialic acid per protein volume, total cholesterol in the serum and capillary fragility and number of large spreading forms of platelets features of hemostasis. Thus, diabetic retinopathy is characterized by a wide spectrum of different features containing the parameters of hemostasis. Thrombocytic vascular interactions are characterized by platelet spreading and capillary fragility which are significant for the development of diabetic retinopathy.
Syrbe
G
G
Klinik für Innere Medizin, Arbeitsgruppe EDV, Friedrich-Schiller-Universität Jena, DDR.
Schröder
H
H
Keil
E
E
Jütte
A
A
D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001792:Blood Platelets / Q000502:physiology; D001798:Blood Proteins / Q000032:analysis; D002198:Capillary Fragility; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D003930:Diabetic Retinopathy / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D015999:Multivariate Analysis; D012016:Reference Values; D012794:Sialic Acids / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D001798:Blood Proteins; D012794:Sialic Acids; D002784:Cholesterol
Multivarianzanalyse zur Erfassung diabetestypischer Hämostasekriterien. Teil 3: Ermittlung einer retinopathietypischen Parameter-Konstellation.