title: Granulocyte colony-stimulating factor (G-CSF) treatment in a neutropenic leukemia patient with diffuse interstitial pulmonary infiltrates.
abstract: Adult respiratory distress syndrome (ARDS) in patients suffering from acute leukemia usually occurs during chemotherapy-induced neutropenia. In addition, intensified chemotherapy with high-dose cytosine arabinoside and mediastinal irradiation may contribute to the development of ARDS. This complication is usually refractory to conservative treatment with antibiotics, steroids, and mechanical ventilation. In this report, we describe a 25-year-old patient with acute lymphoblastic leukemia who developed ARDS during the phase of chemotherapy-induced neutropenia. Subcutaneous administration of granulocyte colony-stimulating factor (G-CSF) at doses of 300-600 micrograms/day led to a prompt increase of peripheral granulocyte counts. With resolution of neutropenia, respiratory function gradually improved, and mechanical ventilatory support was stopped after 2 weeks. From this observation we surmise that the application of G-CSF may be an effective therapeutic approach for preventing the fatal outcome of ARDS in leukemia patients with bone marrow aplasia.
authors.affiliation: Abteilung für Hämatologie, Universität Düsseldorf, FRG.
authors.forename: A
authors.initials: A
authors.lastname: Heyll
authors.forename: C
authors.initials: C
authors.lastname: Aul
authors.forename: F
authors.initials: F
authors.lastname: Gogolin
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Arning
authors.forename: A
authors.initials: A
authors.lastname: Gehrt
authors.forename: U
authors.initials: U
authors.lastname: Hadding
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002452:Cell Count; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013902:Radiography, Thoracic; D012128:Respiratory Distress Syndrome / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor