title: Interleukin-1-induced cartilage degradation is independent of substance P level in rabbit knees.
abstract: The effect of SP on recombinant human IL-1 alpha-induced cartilage degradation in rabbit knees was investigated. Co-injection of 10 ng IL-1 and 1 micrograms SP did not increase cartilage degradation above the level observed after injection of 10 ng IL-1 alone. Co-injection of 100 ng IL-1 and 150 micrograms Spantide, a potent SP antagonist, did not reduce the level of cartilage degradation. Infusion of 100 ng SP/day for two weeks did not induce cartilage degradation. These observations suggest that cartilage degradation induced by IL-1 is independent of SP concentrations in rabbit knees.
authors.affiliation: CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901.
authors.forename: E M
authors.initials: EM
authors.lastname: O'Byrne
authors.forename: R L
authors.initials: RL
authors.lastname: Goldberg
authors.forename: J R
authors.initials: JR
authors.lastname: Doughty
authors.forename: M
authors.initials: M
authors.lastname: Wong
authors.forename: V
authors.initials: V
authors.lastname: Blancuzzi
authors.forename: D
authors.initials: D
authors.lastname: Wilson
authors.forename: A Y
authors.initials: AY
authors.lastname: Jeng
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000187:drug effects* / Q000473:pathology; D006614:Hindlimb; D007270:Injections, Intra-Articular; D007375:Interleukin-1; D007592:Joint Diseases / Q000139:chemically induced / Q000378:metabolism*; D007596:Joints / Q000378:metabolism; D007632:Keratan Sulfate / Q000378:metabolism; D011817:Rabbits; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000037:antagonists & inhibitors; D011994:Recombinant Proteins; D013373:Substance P / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D007375:Interleukin-1; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D011994:Recombinant Proteins; D013373:Substance P; D007632:Keratan Sulfate; C042867:spantide