[Lymphocytes, Langerhans cells and CD68-positive monocytes/macrophages in the skin of HIV-infected patients and normal controls].
Human epidermal Langerhans cells play an important role in the immunoregulation of the skin. We measured the numbers of CD(3+)-, CD(8+)-, CD1a(+)-, HLADR(+)-, IL2R(+)-, CD(4+)- and CD68 positive cells in the skin of 8 asymptomatic HIV-infected Persons, 3 Patients with AIDS and 11 healthy volunteers by suction blister technique. Our results indicate increased numbers of CD1a+ cells and increased numbers of CD4+ cells in the epidermis in asymptomatic HIV-infection. At the same time CD68+ cells are decreased already in an early stage of HIV-Infection. The number of CD1a/CD4+ cells is related to the degree of immunodeficiency. This fact might be caused by the activation of MPS.
Weier
S
S
Med. Klinik II, Städtische Kliniken, Offenbach, Main.
Müller
H
H
Stutte
H J
HJ
Kappus
R
R
Berger
S
S
Shah
P M
PM
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000473:pathology; D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000473:pathology*; D008297:Male; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000473:pathology*; D012016:Reference Values; D012867:Skin / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule
Lymphocyten, Langerhanszellen und CD68-positive Monocyten/Makrophagen in der Haut HIV-infizierter Personen und gesunder Kontrollpersonen.