[The effect of cyclic nucleotides on the rhythmogenicity of the lymphatic center in the frog Rana temporaria].
Studies have been made of the effect of cAMP on the spontaneous impulse activity of lymphatic pacemaker neurons in the frog. It was shown that inhibition of phosphodiesterases by papaverine and 3-isobutyl-1-methylxanthin resulted in the increase in rhythm of bursting impulse activity of the lymphatic centre turning it into a continuous one. The same effect was produced by dibutyryl-cAMP, and to a lower extent--by cAMP. CGMP blocked rhythmic activity of the centre. Possible role of cyclic nucleotides in rhythmic activity of pacemaker cells in the spinal centre of the lymphatic hearts in the frog is discussed.
Serbeniuk
Ts V
TsV
Lelekova
T V
TV
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D008221:Lymphoid Tissue / Q000187:drug effects / Q000502:physiology*; D009712:Nucleotides, Cyclic / Q000494:pharmacology / Q000502:physiology*; D010208:Papaverine / Q000494:pharmacology; D010507:Periodicity; D010726:Phosphodiesterase Inhibitors; D011896:Rana temporaria / Q000502:physiology*; D012969:Sodium Fluoride / Q000494:pharmacology; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology
D009712:Nucleotides, Cyclic; D010726:Phosphodiesterase Inhibitors; D012969:Sodium Fluoride; D010208:Papaverine; D000262:Adenylyl Cyclases; D015056:1-Methyl-3-isobutylxanthine
Vliianie tsiklicheskikh nukleotidov na ritmogenez limfaticheskogo tsentra liagushki Rana temporaria.