[The influence of inhibitors of kinin biosynthesis, prostaglandins and angiotensin II on the vascular and tubular effects of strophanthin in the rat kidney].
Strophanthin was shown to increase the blood flow in the external, internal zones of the cortex and the external medulla of the rat kidney without influencing the blood supply to the internal zone of the medulla. Contrikal eliminates the vasodilating effect of the drug in the mentioned zones of the renal tissue and significantly increases its natriuretic action. Indomethacin also prevents the hemodynamic shift occurring in the kidneys under the influence of strophanthin but fails to change the character of the natriuretic effect of the drug. Captopril exerts no influence on the increase of the blood flow in the external medulla but eliminates the vasodilating effect of strophanthin in the cortex and significantly potentiates its natriuretic action.
Kuz'min
O B
OB
Tarasov
S V
SV
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D002216:Captopril / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D016234:Kallikrein-Kinin System / Q000187:drug effects; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects; D007684:Kidney Tubules / Q000187:drug effects*; D007705:Kinins / Q000037:antagonists & inhibitors*; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects; D013328:Strophanthins / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
D007705:Kinins; D011453:Prostaglandins; D013328:Strophanthins; D000804:Angiotensin II; D007611:Aprotinin; D002216:Captopril; D007213:Indomethacin
Vliianie ingibitorov biosinteza kininov, prostaglandinov i angiotenzina II na sosudistyĭ i kanal'tsevyĭ éffekty strofantina v pochke krysy.