title: Prostate-specific antigen levels from completely sectioned, clinically benign, whole prostates.
abstract: Clinically benign whole, untrimmed prostates and pelvic lymph nodes were obtained from 105 patients at autopsy. All 105 patients had premortem serum from which prostate-specific antigen (PSA) levels were obtained. Sixty-eight did not have carcinoma of the prostate (CAP), 28 had CAP less than 1 ml and 9 had CAP larger than 1 ml. Eleven untrimmed prostates weighed 80 g or more and eight had elevated PSA levels (more than 4.0 ng/ml): five of eight without CAP, two of two with CAP less than 1 ml, and one of one with CAP larger than 1 ml. Ninety-four whole untrimmed prostates weighed less than 80 g and 20 had elevated PSA levels: ten of 60 without CAP, two of 26 with CAP less than 1 ml, and eight of eight with CAP larger than 1 ml. This study suggests that PSA levels from patients with untrimmed prostates weighing 80 g or more (equivalent to a 60-g trimmed prostate) are usually elevated regardless whether CAP is present. However, CAP less than 1 ml, in untrimmed prostates less than 80 g, usually does not elevate PSA levels whereas CAP larger than 1 ml usually does (P less than 0.0001). The likelihood that elevated PSA levels, from patients with untrimmed prostates less than 80 g, are due to CAP larger than 1 ml increases as the PSA level increases.
authors.affiliation: Department of Anatomic Pathology, Veterans Administration Medical Center, Temple, Texas.
authors.forename: P N
authors.initials: PN
authors.lastname: Brawn
authors.forename: V O
authors.initials: VO
authors.lastname: Speights
authors.forename: D
authors.initials: D
authors.lastname: Kuhl
authors.forename: M
authors.initials: M
authors.lastname: Riggs
authors.forename: A M
authors.initials: AM
authors.lastname: Spiekerman
authors.forename: R G
authors.initials: RG
authors.lastname: McCord
authors.forename: K S
authors.initials: KS
authors.lastname: Coffield
authors.forename: D T
authors.initials: DT
authors.lastname: Stewart
authors.forename: M L
authors.initials: ML
authors.lastname: Lind
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D001344:Autopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000033:anatomy & histology / Q000276:immunology*; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000473:pathology; D011472:Prostatitis / Q000276:immunology; D013223:Statistics as Topic
chemical_list: D000951:Antigens, Neoplasm; D017430:Prostate-Specific Antigen