title: Injury of rat renal vessels following extracorporeal shock wave treatment.
abstract: The locations of extracorporeal shock wave treatment induced renal vascular injury and the sources of significant renal hemorrhage were determined in a rat model by means of two different vascular casting procedures. Silicone-rubber injected vascular preparations for light microscopy or corrosion casts for scanning electron microscopy were made following gross examination of the treated organs and their contralateral controls. After 1000 shock waves at 18 kV, five out of 20 treated kidneys appeared to be normal or minimally affected, while 15 showed gross evidence of marked vascular injury. Gross interstitial hemorrhage (15/20), subcapsular hematomas (7/20), and hemorrhages into the renal pelvis (5/20) were confirmed by extravasations of casting materials. These could be traced back to their vascular sources in several instances. Disruptions of interlobar and arcuate veins gave rise to most significant interstitial, subcapsular, and renal pelvic extravasations. On a microscopic scale cortical venules were among the most frequently injured vessels. The arterial vasculature was not spared. Arterial injury ranged from complete arcuate occlusion to small afferent arteriolar and glomerular capillary extravasations. The significance of shock wave induced vascular injury is discussed with respect to potential clinical side effects of ESWL.
authors.affiliation: Department of Surgery, University of Arizona College of Medicine, Tucson.
authors.forename: C
authors.initials: C
authors.lastname: Weber
authors.forename: M E
authors.initials: ME
authors.lastname: Moran
authors.forename: E J
authors.initials: EJ
authors.lastname: Braun
authors.forename: G W
authors.initials: GW
authors.lastname: Drach
mesh_terms: D000818:Animals; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology; D008096:Lithotripsy / Q000009:adverse effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000293:injuries* / Q000473:pathology; D012082:Renal Veins / Q000293:injuries* / Q000473:pathology