[Nature of the reaction of the immunocompetent cells in children with nephrotic syndrome and in their parents with different HLA phenotypes].
The purpose of the study was to analyze the character of the expression of the blood lymphocyte epitopes SD4, SD8 (EBLE SD4, SD8) in a series of the loading in-vitro tests in children suffering from the nephrotic syndrome, with different HLA haplotypes. Nine children with the hormone-sensitive nephrotic syndrome (HSNS) and hormone-resistant nephrotic syndrome (HRNS) and 11 parents were examined. Before and after the in-vitro loading with medicamentous agents EBLE SD4, SD8 were determined by flow cytofluorometry, while HLA antigens were tested by the standard micro-lymphocytotoxic method. The studies allowed revealing differences in the responses of EBLE SD8 to the in-vitro loading in children with the HRNS and HSNS. The character of EBLE SD4, SD8 in a child with the NS and its parents may attest to the involvement of those antigens in the pathogenetic component of the given disease.
Korneeva
V A
VA
Tananov
A T
AT
Stefani
D V
DV
Ruzhitskaia
E A
EA
D000293:Adolescent; D000328:Adult; D015704:CD4 Antigens / Q000235:genetics / Q000276:immunology*; D016827:CD8 Antigens / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D066298:In Vitro Techniques; D007978:Levamisole / Q000494:pharmacology; D008297:Male; D009404:Nephrotic Syndrome / Q000235:genetics / Q000276:immunology*; D010290:Parents; D010641:Phenotype; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D000939:Epitopes; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D007978:Levamisole; D006854:Hydrocortisone
Kharakter reaktsiĭ immunokompetentnykh kletok u deteĭ s nefroticheskim sindromom i u ikh roditeleĭ pri razlichnykh fenotipakh HLA.