Cytomegalovirus-antibody-negative lymphocytes have increased permissiveness for human immunodeficiency virus.
Synergistic activity between cytomegalovirus (CMV) and human immunodeficiency virus (HIV) was observed. In vitro, lymphocytes which were CMV-antibody-negative showed greater cytopathic effects due to HIV than those which were antibody-positive. These cytopathic effects included increased cell death and greater virus production. In vitro stimulation of host lymphocytes with CMV was found to be analogous to that of interleukin-2 stimulation in terms of HIV production and cytopathic effects.
Bartzatt
R L
RL
Eppley Institute, University of Nebraska Medical Center, Omaha 68198.
D000914:Antibodies, Viral / Q000276:immunology; D002478:Cells, Cultured; D003587:Cytomegalovirus / Q000254:growth & development* / Q000276:immunology; D003588:Cytopathogenic Effect, Viral; D006678:HIV / Q000187:drug effects / Q000254:growth & development* / Q000276:immunology; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000382:microbiology*; D012194:RNA-Directed DNA Polymerase; D014779:Virus Replication / Q000187:drug effects
D000914:Antibodies, Viral; D007376:Interleukin-2; D012194:RNA-Directed DNA Polymerase