title: The origin of the vestibulo-cochlear projection in the guinea pig.
abstract: Previous tracer studies have revealed the sacculus to be connected to the vestibular and cochlear nuclei in the guinea pig. Due to its own innervation pattern, an anterior and posterior part of the sacculus can be distinguished. The present study investigated whether the two parts differ concerning their fiber contribution to the vestibulo-cochlear projection. After tracing the nerve of the posterior sacculus with horseradish peroxidase (HRP), the vestibulo-cochlear fibers were clearly recognizeable and showed distinct terminal labeling within the cochlear nuclei. In contrast, no terminals were identified in the cochlear nuclei after tracing the anterior sacculus. These results may further substantiate the guinea pig vestibulo-cochlear projection as a central pathway for saccular acoustic sensation.
authors.affiliation: Department of Otorhinolaryngology, University of Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Gstoettner
authors.forename: M
authors.initials: M
authors.lastname: Burian
authors.forename: R
authors.initials: R
authors.lastname: Zundritsch
authors.forename: R
authors.initials: R
authors.lastname: Mayr
mesh_terms: D000344:Afferent Pathways / Q000033:anatomy & histology; D000818:Animals; D001306:Auditory Pathways / Q000033:anatomy & histology*; D001370:Axonal Transport; D003051:Cochlea / Q000294:innervation*; D003056:Cochlear Nerve / Q000033:anatomy & histology*; D006168:Guinea Pigs; D006735:Horseradish Peroxidase; D008297:Male; D009412:Nerve Fibers / Q000648:ultrastructure; D012444:Saccule and Utricle / Q000294:innervation; D014722:Vestibule, Labyrinth / Q000294:innervation*
chemical_list: D006735:Horseradish Peroxidase