Travel stress alters the intestinal migrating myoelectric complex in rats: antagonist effect of trimebutine.
A novel stress model was developed that may closely resemble a real-life situation. Intestinal motility was monitored in rats before and after a 12 hour train voyage (travel stress). Travel stress reduced the duration of phase III of the intestinal MMC by 30% (3.2 +/- 0.3 vs 4.7 +/- 0.6 min; p less than 0.001) while the durations of phase I and II were unaffected. This effect persisted for two days. Phase III duration returned to basal values after 3 days indicating a reversible alteration on intestinal migrating myoelectric complex (MMC). The infusion of trimebutine at a flow rate of 166 micrograms/kg/h during the stress exposure abolished the changes observed in the duration of phase III of the MMC; the infusion of diazepam (16.6 micrograms/kg/h) had no effect. These results indicate that the travel stress model may be similar to common life events that induce alterations of intestinal motility. Furthermore, trimebutine prevented the reduction of phase III duration induced by travel stress suggesting its possible action on mechanisms involved in the mediation of the stress-induced intestinal motility changes.
Diop
L
L
Institut de recherche Jouveinal, Fresnes, France.
Pascaud
X
X
Le Gallou
B
B
Junien
J L
JL
D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D014195:Travel; D014287:Trimebutine / Q000494:pharmacology
D003975:Diazepam; D014287:Trimebutine