[Changes in hormonal homeostasis and development of disorders of the cardiovascular system in patients with prostatic cancer on estrogen therapy].
Cardiac pains related to estrogen therapy for prostatic cancer (PC) emerged in 53% of treated patients with ischemic heart disease (IHD). The pain complaints were associated with impairment of coronary circulation in 48% of cases. This clinical condition is attributed to elevated STH levels and a trend to hypercorticism. In hypertensive PC patients estrogens provoked more frequent and severe headaches which occurred at initial stages of the treatment in 23% and after 1-year administration of hormones in 44% of patients. Hypertensive reactions may be caused by aldosterone and prolactin hyperproduction. Observation of the therapist and endocrinologist can help to prevent complications in IHD patients with PC.
Gembitskiĭ
E V
EV
Begunov
A V
AV
D000305:Adrenal Cortex Hormones / Q000097:blood*; D000368:Aged; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D004967:Estrogens / Q000009:adverse effects*; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006706:Homeostasis; D006801:Humans; D008297:Male; D010907:Pituitary Hormones / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000188:drug therapy; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D004967:Estrogens; D012739:Gonadal Steroid Hormones; D010907:Pituitary Hormones
Izmenenie gormonal'nogo gomeostaza i razvitie narusheniĭ serdechno-sosudistoĭ sistemy u bol'nykh rakom predstatel'noĭ zhelezy v protsesse éstrogenoterapii.