title: Activity-sensing rate responsive versus conventional fixed-rate pacing: a comparison of rate behavior and patient well-being during routine daily exercise.
abstract: Rate responsive single chamber pacing (VVIR) may be the pacemaker of choice in patients who are not suitable candidates for a dual chamber system. Several studies, most of them performed in an exercise laboratory, have shown a significantly higher exercise capacity demonstrating an improvement in cardiac output and anaerobic threshold compared to conventional fixed rate pacing (VVI). Expressing our idea that stress testing in an "artificial environment" on a bicycle or motor driven treadmill has its limitations and may be difficult to extend into patient's daily life, we designed an outdoor study imitating patient's daily activity. Twenty-one patients with an activity-sensing rate responsive pacemaker performed in a double blind fashion in VVI and VVIR mode the following test circuit: walking 170 meters on flat ground, 210 meters incline, climbing a flight of stairs, and the same circuit in reverse order, and therefore "downhill". Heart rate behavior was recorded by Holter monitoring and patients subjective feelings of well-being, i.e. fatigue and dyspnea were also evaluated. VVIR pacing responded promptly to exercise, i.e., walking on a flat ground, but no further significant increase in pacing rate was observed in relationship to the strength of physical activity while walking inclined or climbing stairs. While patients became exhausted, a nonphysiological decrease in heart rate sometimes occurred. Despite these limitations 6 of 12 patients who had a paced-only rhythm while exercising in both VVI and VVIR mode reported feeling significantly better in the VVIR mode, expressing less dyspnea and fatigue. In contrast, two of nine patients having only intermittently paced rhythm preferred the VVIR mode. Patients with lower ejection fraction (EF) were more likely to show subjectively a benefit while exercising in VVIR mode, compared to those with less reduced or normal EF. Despite the technical limitations of using a piezo crystal for rate adaptation, VVIR pacing is an important option in paced-only patients, but it seems less beneficial in patients with only intermittent paced rhythm.
authors.affiliation: Department of Internal Medicine, University Hospital, Zurich, Switzerland.
authors.forename: R A
authors.initials: RA
authors.lastname: Candinas
authors.forename: H O
authors.initials: HO
authors.lastname: Gloor
authors.forename: F W
authors.initials: FW
authors.lastname: Amann
authors.forename: M
authors.initials: M
authors.lastname: Schoenbeck
authors.forename: M
authors.initials: M
authors.lastname: Turina
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001294:Attitude to Health; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004311:Double-Blind Method; D004417:Dyspnea / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005221:Fatigue / Q000503:physiopathology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008124:Locomotion / Q000502:physiology; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume / Q000502:physiology; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology