Liposomes and biotherapeutics.
Application of liposomes as delivery system for biotherapeutic peptides and proteins may offer important therapeutic advantages over existing delivery methods. Several approaches towards achieving improved delivery of biotherapeutics with liposomes are outlined. Although the literature on this topic is sporadic and frequently incomplete, enough of a research foundation exists to justify the conclusion that liposomes can play an important role in the formulation and delivery of biotherapeutics. However, it will be necessary to understand more fully the mechanisms of action before optimum liposomal dosage forms can be designed.
Storm
G
G
Dept of Pharmaceutics, University of Utrecht, The Netherlands.
Wilms
H P
HP
Crommelin
D J
DJ
D000818:Animals; D004337:Drug Carriers; D006801:Humans; D007372:Interferons / Q000008:administration & dosage; D008081:Liposomes; D016215:Macrophage-Activating Factors / Q000008:administration & dosage; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use; D011506:Proteins / Q000008:administration & dosage / Q000627:therapeutic use
D004337:Drug Carriers; D008081:Liposomes; D016215:Macrophage-Activating Factors; D010455:Peptides; D011506:Proteins; D007372:Interferons