Dimethyl sulfoxide inhibits human immunodeficiency virus production in vitro.
LDV/7, H9, and MOLT-4, three cell lines infectible by human immunodeficiency virus were incubated with dimethyl sulfoxide, an inducer of cell differentiation. It was shown that this is a powerful inhibitor of viral production, but its effect is transient: viral production resumes when the compound is removed from the culture medium. It does not inactivate the virus, and it fails to prevent viral infection or to inhibit expression of p24 on the surface of the infected cells.
Viza
D
D
CNRS URA 216, Laboratoire d'Immunobiologie, Faculté de Médecine, Paris, France.
Aranda-Anzaldo
A
A
Zompetti
C
C
Vich
J M
JM
D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D015683:Gene Products, gag / Q000096:biosynthesis; D006678:HIV / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D016655:HIV Core Protein p24; D006801:Humans; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D014758:Viral Core Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects*
D015683:Gene Products, gag; D016655:HIV Core Protein p24; D014758:Viral Core Proteins; D012194:RNA-Directed DNA Polymerase; D004121:Dimethyl Sulfoxide