Selective and effective cleavage of RNAs by vinyladenine-vinylamine copolymer.
Poly(uridylic acid) (poly[U]) and poly(adenylic acid) (poly[A]) are efficiently cleaved, via phosphodiester linkage hydrolysis, at pH 8, 50 degrees C by use of poly(vinyladenine-co-vinylamine) as catalyst. The catalytic activity of the copolymer surpasses the value of poly(vinylamine), indicating a significant role of the adenine residue in the copolymer for the effective catalysis.
Shiiba
T
T
Institute of Material Science, University of Tsukuba, Ibaraki, Japan.
Komiyama
M
M
Yashima
E
E
Akashi
M
M
D006868:Hydrolysis; D011061:Poly A / Q000737:chemistry; D011072:Poly U / Q000737:chemistry; D011145:Polyvinyls / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D011145:Polyvinyls; D011061:Poly A; D011072:Poly U; D012313:RNA