[Immunophenotypic and genotypic characterization of T-cell populations in thymomas].
The T cell component of eight thymomas has been studied by immunohistochemistry and Southern blot analysis. In the cortical areas of thymomas the T cells expressed an immature cortical phenotype. In cortical and medullary areas T cell Receptor (TcR) alpha-beta lymphocytes heavily predominated over TcR gamma-delta lymphocytes. No genomic rearrangement of TcR and Immunoglobulin genes could be detected, thus supporting the non neoplastic nature of the lymphocyte component in thymomas.
Scherrer
C C
CC
Institut für Pathologie, Universität Zürich.
Knecht
H
H
Wiesli
M
M
Dirsch
O R
OR
Odermatt
B
B
Heitz
P U
PU
D015703:Antigens, CD / Q000032:analysis; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000473:pathology; D013945:Thymoma / Q000276:immunology* / Q000473:pathology; D013953:Thymus Neoplasms / Q000276:immunology* / Q000473:pathology
D015703:Antigens, CD; D006684:HLA-DR Antigens; D007136:Immunoglobulins
Immunphaenotypische und genotypische Charakterisierung der T-Zellpopulation in Thymomen.