The effects of cocaine upon 5-hydroxyindole levels of the maturing mouse brain.
1. Mice at various ages between birth and adulthood were injected with cocaine hydrochloride (30 mg/kg) and then their brains were assayed for 5-hydroxytryptamine (5-HT) and 5-hydroxyindole acetic acid (5-HIAA). 2. Changes in the levels of both metabolites were in keeping with 5-HT uptake inhibition at all ages.
Baker
P C
PC
Department of Biology, Cleveland State University, OH 44115.
Hoff
K M
KM
D000375:Aging / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D003042:Cocaine / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D003042:Cocaine