title: SCE-measurements as tool for evaluation of drug-induced chromosomal disorders.
abstract: A staining procedure that detects sister chromatid exchanges has been used to examine the response of chromosomes in cultured human fibroblasts to a series of chemical and physical mutagens. The test represents a sensitive and reproducible method for detecting mutagenicity on the chromosome level. It provides a powerful method for the detection of environmental mutagens and can be used in ocular toxicity studies.
authors.affiliation: Institute of Radiation Biology, Bonn, FRG.
authors.forename: C
authors.initials: C
authors.lastname: Baumstark-Khan
authors.forename: H
authors.initials: H
authors.lastname: Rink
mesh_terms: D001761:Bleomycin / Q000633:toxicity; D001973:Bromodeoxyuridine / Q000633:toxicity; D002453:Cell Cycle; D004252:DNA Mutational Analysis; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D008938:Mitosis; D009152:Mutagenicity Tests; D015203:Reproducibility of Results; D012854:Sister Chromatid Exchange / Q000187:drug effects* / Q000528:radiation effects; D014407:Tumor Cells, Cultured; D014466:Ultraviolet Rays; D014965:X-Rays
chemical_list: D001761:Bleomycin; D005020:Ethyl Methanesulfonate; D001973:Bromodeoxyuridine