[Severe ventricular arrhythmia secondary to indapamide-induced hypopotassemia].
We report on two patients, treated with indapamide for mild hypertension, who developed life-threatening ventricular arrhythmias. The former showed severe hypokalemia, QT interval prolongation and "torsade de pointes": the latter, who suffered from ischemic heart disease, had slightly decreased serum potassium and ventricular fibrillation. In both cases no other cause accounting for hypokalemia and ventricular arrhythmia was found. Therefore we stress that serum potassium and ECG must be carefully monitored during indapamide therapy, mainly in patients with cardiac disease.
Guzzini
F
F
Divisione di Medicina II, U.S.S.L. 9, Ospedale di Saronno.
Baroffio
R
R
Coppetti
D
D
Gasparini
P
P
D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000209:etiology; D005117:Cardiac Complexes, Premature / Q000139:chemically induced; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced* / Q000150:complications; D007190:Indapamide / Q000009:adverse effects*; D013614:Tachycardia, Paroxysmal / Q000139:chemically induced; D016171:Torsades de Pointes / Q000139:chemically induced; D014693:Ventricular Fibrillation / Q000139:chemically induced
D007190:Indapamide
Aritmie ventricolari gravi secondarie a ipopotassiemia indotta dall'indapamide.