Reduced attention-related negative potentials in schizophrenic children.
ERPs were recorded from normal and schizophrenic children during performance of a reaction time task (RT) followed by a complex visual discrimination, the span of apprehension task (Span), sensitive to vulnerability factors in schizophrenia. Subjects responded rapidly to the onset of the visual arrays in the RT condition and differentially to the presence of 1 of 2 target letters in the Span condition. The EEG was recorded at 19 scalp sites and ERPs included activity 1 sec before through 1 sec after Span array onset. Difference potentials (Span-RT) were computed to remove unvarying exogenous activity, thus isolating endogenous activity associated with the processing demands of the Span task. When RT and Span task ERPs are compared, schizophrenic children produced a significantly smaller than normal increment in endogenous negative activity. This endogenous negativity differed in its topography and time course from the exogenous components (P1, N1 and P2), and most likely reflects attentional effort associated with serial search, pattern recognition and stimulus identification. We believe that the current results support the position that schizophrenics are impaired in their ability to allocate adequate attentional resources for the processing of the Span stimuli. It is important to note that this deficit is apparent quite early in discriminative processing.
Strandburg
R J
RJ
Dept. of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles.
Marsh
J T
JT
Brown
W S
WS
Asarnow
R F
RF
Guthrie
D
D
Higa
J
J
D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D002648:Child; D003265:Contingent Negative Variation; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*