Granulocyte colony-stimulating factor in cerebrospinal fluid from patients with meningitis.
Granulocyte colony-stimulating factor (G-CSF) in the cerebrospinal fluid from patients with meningitis was measured by our modified enzyme-linked immunosorbent assay for G-CSF. The minimal detection level was 20 pg/mL G-CSF. In patients with bacterial meningitis, the G-CSF levels in the cerebrospinal fluid were extremely elevated, showing a mean value of approximately 1,500 pg/mL. On the other hand, G-CSF levels in the cerebrospinal fluid from 67% patients with aseptic meningitis were moderately increased, showing a mean value of about 80 pg/mL, whereas G-CSF levels in 33% samples remained undetectable. The G-CSF levels and neutrophil counts in the cerebrospinal fluid were proven to be related by Spearman's rank correlation coefficient analysis (r = .724). These elevations of G-CSF levels at inflammation sites associated with bacterial meningitis may indicate that G-CSF plays an important role in the combat of bacterial infections.
Shimoda
K
K
First Department of Internal Medicine, Kyushu University, Fukuoka, Japan.
Okamura
S
S
Omori
F
F
Mizuno
Y
Y
Hara
T
T
Aoki
T
T
Ueda
K
K
Niho
Y
Y
D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D016179:Granulocyte Colony-Stimulating Factor / Q000134:cerebrospinal fluid* / Q000494:pharmacology; D006410:Hematopoiesis; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D008581:Meningitis / Q000097:blood / Q000134:cerebrospinal fluid*; D009504:Neutrophils
D016179:Granulocyte Colony-Stimulating Factor