Uric acid as an inhibitor of biochemical changes induced by cyclophosphamide in mice.
The biochemical changes induced by uric acid, cyclophosphamide and uric acid plus cyclophosphamide were evaluated in Swiss albino male mice. Uric acid dissolved in water was administered orally in different doses for 7 days. Some mice from each group were injected intraperitoneally with cyclophosphamide (25 mg/kg) and sacrificed after 30 h. The blood of all animals was analyzed for uric acid levels. Uric acid was found not to affect the biosynthesis of nucleic acids and proteins in liver, testes and brain at 10-100 mg/kg/d. Pretreatment with uric acid provided significant protection against cyclophosphamide-induced impairment of DNA, RNA and protein biosynthesis.
al-Bekairi
A M
AM
Quality Control and Research Laboratory, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Shah
A H
AH
Chaudhry
M A
MA
Qureshi
S
S
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D012016:Reference Values; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood / Q000494:pharmacology*
D011506:Proteins; D014527:Uric Acid; D012313:RNA; D003520:Cyclophosphamide; D004247:DNA