Tissue specificity of the endothelin-induced responses.
Endothelin (ET-1) has many activities in various tissues and organs. Even in the vascular system, ET-1 elicits vasodilation as well as vasoconstriction. These diverse responses induced by ET-1 are ascribed to the balance between ET-1 and ET-3 effects that are mediated by (a) at least two types of calcium channel activated by ET, (b) three distinct prototypes of ET-receptor subtypes, (c) the diversity of the intracellular signal transduction system, especially cyclooxygenase products, and (d) modulation of hormonal and neuronal factors.
Masaki
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Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
D000818:Animals; D016232:Endothelins / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D009928:Organ Specificity / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D017466:Receptors, Endothelin; D015398:Signal Transduction / Q000502:physiology
D016232:Endothelins; D011956:Receptors, Cell Surface; D017466:Receptors, Endothelin