title: Isochromosome (6p) in Waldenstrom's macroglobulinemia.
abstract: Cytogenetic data on two cases of previously treated Waldenstrom's macroglobulinemia (WM) are presented. An i(6p) was identified in 60 and 56% of bone marrow (BM) metaphases from each patient, respectively. In both cases, i(6p) occurred as part of a complex karyotype but was also observed as the sole abnormality in a proportion of metaphases. The literature on the cytogenetics of WM and the relevance of i(6p) is discussed.
authors.affiliation: Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff.
authors.forename: A D
authors.initials: AD
authors.lastname: White
authors.forename: R E
authors.initials: RE
authors.lastname: Clark
authors.forename: A
authors.initials: A
authors.lastname: Jacobs
mesh_terms: D002869:Chromosome Aberrations; D002893:Chromosomes, Human, Pair 3; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics*