title: Nodular hepatocellular carcinoma. Treatment with subsegmental intraarterial injection of iodine 131-labeled iodized oil.
abstract: Internal radiation therapy with subsegmental arterial injection of iodine 131(131I)-labeled iodized oil (Lipiodol; Laboratorie, Guerbet, France) was evaluated in 24 patients with nodular hepatocellular carcinoma (HCC) ranging from 2.5 to 8.0 cm in size. 131I Lipiodol (555 to 2220 MBq in 3 to 8 ml) was injected depending on the tumor size. Tumor reduction was seen in 88.9% of tumors smaller than 4.0 cm in diameter, 65.5% of tumors between 4.1 to 6.0 cm, and 25.0% of tumors larger than 5.1 cm. The tumor size reduction corresponded to the gradual drop of serum alpha-fetoprotein (AFP) levels and devascularization on follow-up angiography. Adverse reactions from treatment included fever, mild abdominal pain, nausea, and elevation of transaminases. These were mild and well tolerated by patients. This method provided long-term local control without complications related to the thyroid, lung, gastrointestinal tract, and bone marrow.
authors.affiliation: Department of Radiology, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Yoo
authors.forename: J T
authors.initials: JT
authors.lastname: Lee
authors.forename: K W
authors.initials: KW
authors.lastname: Kim
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Choi
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
authors.forename: C I
authors.initials: CI
authors.lastname: Park
authors.forename: C Y
authors.initials: CY
authors.lastname: Park
authors.forename: J H
authors.initials: JH
authors.lastname: Suh
authors.forename: J J
authors.initials: JJ
authors.lastname: Loh
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D005500:Follow-Up Studies; D006499:Hepatic Artery; D006801:Humans; D007269:Injections, Intra-Arterial; D007457:Iodine Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*; D007459:Iodized Oil / Q000008:administration & dosage / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted; D012074:Remission Induction; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D007457:Iodine Radioisotopes; D000509:alpha-Fetoproteins; D007459:Iodized Oil