Effects of desmopressin and dextran on coagulation and fibrinolysis in healthy volunteers.
The effects of desmopressin and dextran on haemostasis and fibrinolysis were studied in four healthy volunteers. Both drugs were compared to placebo, each volunteer being subject to four experiments. Dextran 70 (30 g i.v.) moderately decreased VIII:C and vWF:Ag and slightly increased antithrombin III, also when haemodilution and diurnal variation were considered. Desmopressin (0.3 micrograms/kg BW i.v.), alone as well as in combination with dextran, increased VIII: C, vWF:Ag, protein C and tPA and decreased PAI-1. The combination of desmopressin and dextran stimulated coagulation and fibrinolysis and might be of relevance to surgical blood loss as well as to postoperative thromboembolism.
Flordal
P A
PA
Department of Surgery, Danderyd Hospital, Sweden.
Svensson
J
J
Ljungström
K G
KG
D000328:Adult; D000941:Antigens / Q000097:blood; D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation / Q000187:drug effects*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D003911:Dextrans / Q000008:administration & dosage / Q000494:pharmacology*; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D015849:Plasminogen Inactivators / Q000097:blood; D011486:Protein C / Q000378:metabolism; D014841:von Willebrand Factor / Q000276:immunology
D000941:Antigens; D003911:Dextrans; D015849:Plasminogen Inactivators; D011486:Protein C; C029417:Von Willebrand antigen; D014841:von Willebrand Factor; D000990:Antithrombin III; D005169:Factor VIII; D003894:Deamino Arginine Vasopressin