In vivo exposure of human lymphocytes to technetium-99m in nuclear medicine patients does not induce detectable genetic effects.
Recent reports have demonstrated that exposure of nuclear medicine patients to thallium-201 does not result in a detectable increase in mutation at the hprt locus in human lymphocytes. In an effort to study further the potential genetic effects of medical exposures to low dose radiation, we have examined chromosome aberrations and mutations in peripheral blood lymphocytes from nuclear medicine patients exposed to clinical doses of technetium-99m. Our results show that there is no exposure-related increase in chromosomal damage; furthermore, the data do not confirm earlier reports of exposure-related increases in mutations induced by technetium-99m.
Kelsey
K T
KT
Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA 02115.
Donohoe
K J
KJ
Memisoglu
A
A
Baxter
B
B
Caggana
M
M
Liber
H L
HL
D000704:Analysis of Variance; D002869:Chromosome Aberrations; D002999:Clone Cells; D004912:Erythrocytes; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D008677:Metaphase / Q000528:radiation effects; D008938:Mitosis / Q000528:radiation effects; D009152:Mutagenicity Tests; D012907:Smoking; D013670:Sodium Pertechnetate Tc 99m; D013601:T-Lymphocytes / Q000528:radiation effects
D013670:Sodium Pertechnetate Tc 99m