title: cDNAs encoding members of a family of proteins related to human sterol carrier protein 2 and assignment of the gene to human chromosome 1 p21----pter.
abstract: Sterol carrier protein 2 (SCP2) is believed to play a key role in intracellular lipid movement. Here we report the cloning and nucleotide sequences of cDNAs encoding SCP2-related proteins of 58.85 kD and 30.8 kD and the assignment of the SCP2 gene to human chromosome 1 p21-pter. The SCP2-related proteins share common deduced carboxyl amino acid sequences with SCP2 and the cDNAs have a common 3' untranslated nucleotide sequence. The mRNAs encoding these proteins increased in a coordinate fashion as human placental cytotrophoblasts differentiated into syncytiotrophoblasts in culture. Our observations document the existence of a family of related proteins encoded by the human SCP2 gene.
authors.affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia 19104.
authors.forename: Z
authors.initials: Z
authors.lastname: He
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: E E
authors.initials: EE
authors.lastname: Furth
authors.forename: L J
authors.initials: LJ
authors.lastname: Schantz
authors.forename: S L
authors.initials: SL
authors.lastname: Naylor
authors.forename: H
authors.initials: H
authors.lastname: George
authors.forename: J T
authors.initials: JT
authors.lastname: Billheimer
authors.forename: J F
authors.initials: JF
authors.lastname: Strauss
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D015152:Blotting, Northern; D002352:Carrier Proteins / Q000235:genetics*; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010940:Plant Proteins; D011061:Poly A / Q000235:genetics; D016133:Polymerase Chain Reaction; D012313:RNA / Q000235:genetics; D012333:RNA, Messenger; D015183:Restriction Mapping; D013261:Sterols / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D010940:Plant Proteins; D012333:RNA, Messenger; D013261:Sterols; C072087:sterol carrier proteins; D011061:Poly A; D012313:RNA; D004247:DNA