title: Study on the interaction of aromatic dyes with nucleic acids by means of UV, CD and NMR spectroscopies.
abstract: The interaction of several aromatic cationic dyes such as, ethidium bromide (EB), methylene blue (MB), acridine orange (AO), and Hoechst 33258 with calf-thymus DNA and poly(A)-poly(U) duplex was investigated. The different induced extrinsic Cotton effects (greater than 300 nm) were observed for DNA- and RNA-dye complexes. The binding properties of these complexes were examined by UV, CD, and NMR spectroscopies.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kagoshima University, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Yashima
authors.forename: T
authors.initials: T
authors.lastname: Tajima
authors.forename: N
authors.initials: N
authors.lastname: Suehiro
authors.forename: M
authors.initials: M
authors.lastname: Akashi
authors.forename: N
authors.initials: N
authors.lastname: Miyauchi
mesh_terms: D000165:Acridine Orange / Q000378:metabolism; D000818:Animals; D006690:Bisbenzimidazole / Q000378:metabolism; D002417:Cattle; D002942:Circular Dichroism; D004396:Coloring Agents / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004996:Ethidium / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008751:Methylene Blue / Q000378:metabolism; D011063:Poly A-U / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004396:Coloring Agents; D011063:Poly A-U; D004247:DNA; D004996:Ethidium; D000165:Acridine Orange; D006690:Bisbenzimidazole; D008751:Methylene Blue