title: Production of granulocyte colony stimulating factor in decidual tissue and its significance in pregnancy.
abstract: The increase of the number of polymorphonuclear leukocytes (PMN) in peripheral blood during pregnancy is well known. Granulocyte colony stimulating factor (G-CSF) has been found to act as a hemopoietic factor for PMN. This study analyzed G-CSF concentrations in the peripheral blood of pregnant women and examined whether decidual tissue acted as source of G-CSF production. The proliferation of chorionic cells measured by [3H]-thymidine uptake and its association with G-CSF were also examined. The results revealed that the concentration of G-CSF increased during the course of pregnancy and was positively correlated with the number of PMN. Large amounts of G-CSF was produced in cultures of decidual cells. We also found that G-CSF stimulates the proliferation of the chorionic cells. It was concluded that the decidual cells have a G-CSF producing activity associated with the elevation of PMN and play some role in the proliferation of chorionic cells during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan.
authors.forename: J S
authors.initials: JS
authors.lastname: Duan
mesh_terms: D003656:Decidua / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn / Q000097:blood; D009994:Osmolar Concentration; D011247:Pregnancy / Q000097:blood / Q000378:metabolism*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor