[Vasoconstriction of dog nasal mucosa caused by histamine].
Nasal mucosa was obtained from 12 dogs. The vasoconstrictive effect of histamine was measured with physiological recorder. The results showed that vasoconstriction of the nasal mucosa caused by histamine could be blocked by H1 antihistamines or verapamil and not by H2 or alpha antagonists. It suggests that the effect of histamine on nasal mucosa might be mediated by H1 receptor through activation of calcium channel and not by releasing noradrenaline.
Yang
P
P
First Affiliated Hospital, Shanxi Medical College, Taiyuan.
D000818:Animals; D004285:Dogs; D006632:Histamine / Q000494:pharmacology*; D014663:Nasal Decongestants; D009297:Nasal Mucosa / Q000098:blood supply*; D011969:Receptors, Histamine H1 / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D014663:Nasal Decongestants; D011969:Receptors, Histamine H1; D006632:Histamine