Changes in CNS levels of serotonin and its metabolite in SART-stressed (repeatedly cold-stressed) rats.
Central nervous system levels of serotonin (5-HT) and 5-hydroxy-indoleacetic acid (5-HIAA) in SART (specific alternation of rhythm in temperature)-stressed (repeatedly cold-stressed) rats were examined by HPLC-ECD. In SART-stressed rats, the levels of both 5-HT and 5-HIAA decreased in many brain areas. In the spinal cord, only the 5-HT level decreased. Therefore, the ratio of 5-HIAA to 5-HT increased only in the spinal cord. These results suggest that SART-stressed rats have some form of abnormality in the synthetic system of 5-HT.
Hata
T
T
Department of Pharmacology, Faculty of Pharmacy, Kinki University, Higashi-Osaka, Japan.
Itoh
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E
Kawabata
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A
D000818:Animals; D002490:Central Nervous System / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006897:Hydroxyindoleacetic Acid / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis*; D013312:Stress, Physiological / Q000378:metabolism*
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid