Tyrosyl radicals and their role in hydroperoxide-dependent activation and inactivation of prostaglandin endoperoxide synthase.
Smith
W L
WL
Department of Biochemistry, Michigan State University, East Lansing 48824.
Eling
T E
TE
Kulmacz
R J
RJ
Marnett
L J
LJ
Tsai
A
A
D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005609:Free Radicals; D006418:Heme / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism*
D016861:Cyclooxygenase Inhibitors; D005609:Free Radicals; D014443:Tyrosine; D006418:Heme; D006861:Hydrogen Peroxide; D011451:Prostaglandin-Endoperoxide Synthases