Beneficial effects of prewarming the donor liver for rat liver transplantation.
Cold preservation of donor liver can injure the microcirculation enough to impair the function and survival of the transplanted liver. In this study, prewarming the donor liver to 10 degrees C to 12 degrees C after cold storage prior to implantation significantly increased survival rates in rats 1 week after surgery. Following 6, 8, or 9 hours of cold storage in chilled normal saline, prewarming increased survival rates from 40% to 78.6%, from 0% to 35.7%, and from 0% to 14.3%, respectively. The results suggest that pretreatment of the donor liver with warmth following cold storage and before implantation will improve the survival rate of liver transplanted rats.
Xu
H S
HS
Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
Wang
D J
DJ
Pace
R C
RC
Jones
R S
RS
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001646:Bile / Q000378:metabolism; D006358:Hot Temperature; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver; D008102:Liver Circulation / Q000502:physiology; D016031:Liver Transplantation / Q000401:mortality / Q000502:physiology*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains; D015427:Reperfusion Injury / Q000401:mortality / Q000517:prevention & control*; D013997:Time Factors
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases