Ultrasound detection of neural tube defects in patients with elevated maternal serum alpha-fetoprotein.
We conducted this study to determine the accuracy of ultrasound in the prenatal diagnosis of neural tube defects in women with elevated maternal serum alpha-fetoprotein (MSAFP). Among 905 pregnancies, 49 neural tube defects were correctly diagnosed by ultrasound alone; one was not. Ultrasound scanning had 98% sensitivity and 100% specificity for the detection of neural tube defects. The predictive value of a positive ultrasound diagnosis was 100% and of a negative ultrasound 99.9% for neural tube defects. Forty-three other structural abnormalities were also detected in patients with elevated MSAFP, including 19 abdominal wall defects, seven chromosomal abnormalities, five urinary tract abnormalities, one cardiac abnormality, and 11 others. Two chromosomal abnormalities were not detected. We suggest that ultrasound can be used reliably to detect neural tube defects, thereby avoiding the risks of amniocentesis.
Morrow
R J
RJ
Department of Obstetrics and Gynecology, Queen Mother's Hospital, Glasgow, Scotland.
McNay
M B
MB
Whittle
M J
MJ
D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000000981:diagnostic imaging*; D011247:Pregnancy / Q000097:blood*; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins