HIV infection of human gastrointestinal submucosal cells: an in vitro model that mimics Kaposi's sarcoma.
Infection of human gastrointestinal submucosal mesenchymal cells with HIV-1 led to cell populations with abnormal growth properties, increased synthesis of endothelial cell and angioblast markers, and release of angiogenic factors. This system may be the first in vitro model for HIV-induced Kaposi's sarcoma.
Moyer
M P
MP
Department of Surgery, University of Texas Health Science Center, San Antonio 78284.
Ramirez
A
A
Woolf
A
A
Huot
R I
RI
McKee-Suarez
M S
MS
D000951:Antigens, Neoplasm / Q000032:analysis; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000473:pathology; D005169:Factor VIII / Q000032:analysis; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000382:microbiology* / Q000473:pathology; D008648:Mesoderm / Q000382:microbiology / Q000473:pathology; D009389:Neovascularization, Pathologic; D012514:Sarcoma, Kaposi / Q000737:chemistry / Q000382:microbiology* / Q000473:pathology; D014746:Vimentin / Q000032:analysis; D014779:Virus Replication
D000951:Antigens, Neoplasm; D014746:Vimentin; D005169:Factor VIII