Cutaneous and basophilic sensitivity to substance P and gastrin in non-atopic versus atopic subjects.
We compared the cutaneous reaction to intradermal injection of substance P, gastrin and histamine in asymptomatic atopic subjects with a history of hay fever and/or asthma versus non-atopic healthy volunteers. We also studied in these two groups the basophilic histamine release induced by substance P and gastrin with that obtained with anti-human IgE and Con A. Intradermal injection of substance P (3-300 pM) and gastrin (3-30 pM) caused a wheal and flare reaction which was comparable in both groups of subjects. Substance P 10(-4)M caused a mean basophilic histamine release of about 15% in atopic and non-atopic subjects. Gastrin was not effective in this model. Anti-IgE and Con A-induced histamine release was significantly higher in atopic than in non-atopic volunteers.
Louis
R E
RE
Department of Respiratory Medicine, CHU Sart-Tilman, Université de Liège, Belgium.
Radermecker
M F
MF
D000328:Adult; D001491:Basophils / Q000187:drug effects / Q000276:immunology*; D003208:Concanavalin A / Q000008:administration & dosage / Q000494:pharmacology; D005755:Gastrins / Q000008:administration & dosage / Q000494:pharmacology*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D007271:Injections, Intradermal; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000276:immunology*; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D005755:Gastrins; D003208:Concanavalin A; D013373:Substance P; D007073:Immunoglobulin E; D006632:Histamine