title: Autosomal recessive polycystic kidney in rats.
abstract: We evaluated the characteristics of renal lesions in rat autosomal recessive polycystic kidney (ARPK). In rat ARPK, small cysts appeared primarily in the medulla 2 months after birth and gradually extended to the cortex, forming large cysts involving the entire layer after 8 months. By immunofluorescence microscopy, type IV collagen was more strongly stained in the epithelial basement membrane of the rat ARPK than in the normal rat tubular basement membrane (TBM). Electron microscopy demonstrated a marked thickening, slight splitting and lamination of the TBM in the ARPK. As peroxidase-labeled lectins, dolichos biflorus very strongly stained the cyst epithelium whereas lens culinaris did not. These findings indicate that cysts in rat ARPK originate in the collecting duct.
authors.affiliation: Department of Pediatrics, Nihon University, School of Medicine, Tokyo, Japan.
authors.forename: Z
authors.initials: Z
authors.lastname: Inage
authors.forename: Y
authors.initials: Y
authors.lastname: Kikkawa
authors.forename: M
authors.initials: M
authors.lastname: Minato
authors.forename: M
authors.initials: M
authors.lastname: Owada
authors.forename: T
authors.initials: T
authors.lastname: Kitagawa
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: K
authors.initials: K
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Iidaka
mesh_terms: D000367:Age Factors; D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D007685:Kidney Tubules, Collecting / Q000473:pathology; D008854:Microscopy, Electron; D017044:Polycystic Kidney, Autosomal Recessive / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D011922:Rats, Mutant Strains; D013194:Staining and Labeling
chemical_list: D003094:Collagen