Pancreatic enzyme activity in pregnancy.
Serum amylase activity and the amylase:creatinine clearance ratio (Cam:Ccr%) are two of the most commonly used indicators for the diagnosis of pancreatitis. However, published data on the effect of pregnancy on these indicators are conflicting. Furthermore, there are no published data on the effect of pregnancy on serum lipase activity, which is considered one of the most sensitive and specific indicators of pancreatitis. A study was undertaken to determine the effect of pregnancy and gestational age on serum amylase, serum lipase and Cam:Ccr% levels and to establish a baseline of normal values for use in the diagnosis of pancreatitis in pregnant women. Serum amylase, serum lipase and Cam:Ccr% levels were determined on a sample population consisting of 175 pregnant women with gestational ages ranging from 5 to 40 weeks and on a control group of 44 reproductive-age, nonpregnant women. The study results indicated that there is no significant difference in serum amylase, serum lipase and Cam:Ccr% levels between pregnant and nonpregnant women. Cam:Ccr% showed a small but statistically significant increase in the third trimester of pregnancy.
Ordorica
S A
SA
Department of Obstetrics and Gynecology, New York University Medical Center, New York 10016.
Frieden
F J
FJ
Marks
F
F
Hoskins
I A
IA
Young
B K
BK
D000681:Amylases / Q000097:blood* / Q000493:pharmacokinetics / Q000652:urine; D003404:Creatinine / Q000097:blood* / Q000493:pharmacokinetics / Q000652:urine; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D008049:Lipase / Q000097:blood*; D008657:Metabolic Clearance Rate; D011247:Pregnancy / Q000097:blood* / Q000378:metabolism / Q000652:urine; D011446:Prospective Studies; D012016:Reference Values
D003404:Creatinine; D008049:Lipase; D000681:Amylases