Neuropeptides in temporomandibular joints with rheumatoid arthritis: a clinical study.
There is evidence that neuropeptides play a role in the development of arthritis. Synovial fluid from arthritic temporomandibular joints in patients with rheumatoid arthritis was therefore investigated for presence of the neuropeptides calcitonin gene-related peptide, substance P, neurokinin A and neuropeptide Y. All four peptides were found in the synovial fluid above plasma level, but calcitonin gene-related peptide showed the highest concentration and substance P the lowest.
Appelgren
A
A
Department of Clinical Oral Physiology, Karolinska Institutet, Huddinge, Sweden.
Appelgren
B
B
Eriksson
S
S
Kopp
S
S
Lundeberg
T
T
Nylander
M
M
Theodorsson
E
E
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D015288:Neurokinin A / Q000032:analysis / Q000097:blood; D009478:Neuropeptide Y / Q000032:analysis / Q000097:blood; D009479:Neuropeptides / Q000032:analysis*; D013373:Substance P / Q000032:analysis / Q000097:blood; D013582:Synovial Fluid / Q000737:chemistry*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*
D009478:Neuropeptide Y; D009479:Neuropeptides; D013373:Substance P; D015288:Neurokinin A; D015740:Calcitonin Gene-Related Peptide