title: Translocation (8;21) in two cases of refractory anemia with excess of blasts in transformation.
abstract: We report two cases of refractory anemia with excess of blasts in transformation (RAEB-T) with the translocation (8;21), which is frequent in ANLL but not in myelodysplastic syndromes (MDS). A review of such cases leads us to conclude that myeloproliferative disorders characterized by the t(8;21) may be preceded by an MDS phase.
authors.affiliation: Biologia Generale e Genetica Medica, Università di Pavia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Maserati
authors.forename: M
authors.initials: M
authors.lastname: Casali
authors.forename: F
authors.initials: F
authors.lastname: Pasquali
authors.forename: F
authors.initials: F
authors.lastname: Locatelli
authors.forename: S
authors.initials: S
authors.lastname: Giani
authors.forename: L
authors.initials: L
authors.lastname: Prete
authors.forename: M
authors.initials: M
authors.lastname: Zecca
authors.forename: R
authors.initials: R
authors.lastname: Invernizzi
authors.forename: R
authors.initials: R
authors.lastname: Bassan
mesh_terms: D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics* / Q000473:pathology; D001752:Blast Crisis; D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic