title: Study of immune function of cancer patients influenced by supplemental zinc or selenium-zinc combination.
abstract: Since hair Zn and serum Zn are usually decreased in cancer patients, and Zn deficiency may reduce the function of T-cells, granulocytes, and Nk cells, we observed in cancer patients the influences of the Zinc or Selenium-Zinc on DNCB skin delayed hypersensitivity mediated by T cell, and the effects of Zinc on oxidative metabolic function of neutrophils and level of serum interferon that potentiate NK cell activity. The results showed that DNCB skin reaction was strengthened, the oxidative metabolic function of neutrophils and serum interferon level were increased by the drugs. It is reasonable to expect that Zinc or Selenium-Zinc is instrumental in restoring failing immunocompetence of cancer patient.
authors.affiliation: Oncological Institute of Anhui Medical University, Hefei, China.
authors.forename: W
authors.initials: W
authors.lastname: Mei
authors.forename: Z M
authors.initials: ZM
authors.lastname: Dong
authors.forename: B L
authors.initials: BL
authors.lastname: Liao
authors.forename: H B
authors.initials: HB
authors.lastname: Xu
mesh_terms: D004890:Erythema; D006801:Humans; D006968:Hypersensitivity, Delayed; D007372:Interferons / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D012643:Selenium / Q000627:therapeutic use*; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D007372:Interferons; D012643:Selenium; D015032:Zinc