Alpha-2-macroglobulin-kallikrein complex: a temperature-sensitive mediator in contact-system-induced inflammation with a potential role in late and delayed hypersensitivity responses.
Maximal complexing of alpha 2-macroglobulin (alpha 2M) and kallikrein (KK) occurs at a temperature of 22-24 rather than at 37 degrees C. The protease expressivity of the complex is also maximal at 22-24 degrees C. alpha 2M-KK complex, sustained permeability changes in guinea pig skin. These findings suggest that the complex, rather than free KK, could play a role in the kinin release reported in some late-phase reactions, some instances of delayed-type hypersensitivity and some cold-induced reactions.
Lasser
E C
EC
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla.
Lyon
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SG
Negrete
S
S
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D005174:Factor XII / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000503:physiopathology*; D007249:Inflammation / Q000276:immunology*; D007610:Kallikreins / Q000494:pharmacology*; D007616:Kaolin / Q000494:pharmacology; D046911:Macromolecular Substances; D013696:Temperature; D000511:alpha-Macroglobulins / Q000494:pharmacology*
D046911:Macromolecular Substances; C053069:alpha 2-macroglobulin-kallikrein complex; D000511:alpha-Macroglobulins; D007616:Kaolin; D005174:Factor XII; D007610:Kallikreins