[Heat-shock proteins and arthritis].
Heat-shock proteins are a category of proteins which are synthesized under stressful conditions (such as increased temperatures) both by prokaryotic and eukaryotic cells. Heat-shock proteins are a major target of the immune response and thus can be considered dominant antigens. Under physiological circumstances the response to heat-shock proteins is considered to play a role in overall defence against bacterial infections. An aberrant immune response against heat-shock proteins may lead to autoimmunity; adjuvant arthritis in Lewis rats. Current evidence also points towards a role of T cell immunity against heat-shock proteins in the etiology and pathogenesis of human autoimmune diseases such as juvenile chronic arthritis.
Rijkers
G T
GT
Afd. Immunologie en Reumatologie, Universiteitskliniek voor kinderen en jeugdigen, Het Wilhelmina Kinderziekenhuis, Utrecht.
de Graeff-Meeder
E
E
Voorhorst-Ogink
M
M
Zegers
B J
BJ
van Eden
W
W
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology / Q000628:therapy; D001171:Arthritis, Juvenile / Q000276:immunology; D015551:Autoimmunity; D002648:Child; D000939:Epitopes / Q000627:therapeutic use; D006360:Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007114:Immunization; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D006360:Heat-Shock Proteins
Heat-shock eiwitten en arthritis.