[Cell-associated complement regulatory proteins and their relation to disease processes].
C3-deposition is a key step for activation of the complement system, which involves C9-mediated immunocytolysis, immunoadherence, C3 receptor-mediated phagocytosis, NK potentiation, anaphylatoxin release, and amplification of C3 activation. Foreign material is eliminated even in the preimmune stage by these complement functions. Self cells, on the other hand, must circumvent the C3-attack, so that they express complement regulatory proteins, namely C3b/C4b receptor (CR1, CD35), decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46). We herein review the properties of these regulatory proteins and discuss the relationships between disease processes and the aberrance of these regulatory proteins.
Seya
T
T
Department of Immunology, Center for Adult Diseases, Osaka.
D015703:Antigens, CD; D018958:CD55 Antigens; D003165:Complement System Proteins / Q000378:metabolism*; D006800:Deltaretrovirus Infections / Q000276:immunology; D006457:Hemoglobinuria, Paroxysmal / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology; D011951:Receptors, Complement / Q000502:physiology*; D017463:Receptors, Complement 3b
D015703:Antigens, CD; C497857:CD46 protein, human; D018958:CD55 Antigens; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D003165:Complement System Proteins