title: C-jun and jun-B oncogene expression during placental development.
abstract: During embryogenesis, growth and differentiation occur in a sequential, predetermined order suggesting that specific genes are turned on and off in a precise and well-regulated manner. Placental development, which is characterized by massive proliferation and differentiation of multiple cell types, must be similarly regulated. Early response protooncogenes, such as c-jun and jun-B, have been associated with both proliferation and differentiation of different cell types. In this study, using Northern blot analysis, we found that c-jun and jun-B expression occurred in human placentas throughout gestation. Maximal expression of c-jun occurred in early gestation, and maximal expression of jun-B occurred in late gestation. We speculate that peak expression of c-jun in human placenta at early gestation may be related to cytotrophoblastic proliferation and that peak expression of jun-B in late gestation may be related to further terminal differentiation of trophoblastic cells.
authors.affiliation: Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, OH 45267-0526.
authors.forename: L J
authors.initials: LJ
authors.lastname: Dungy
authors.forename: T A
authors.initials: TA
authors.lastname: Siddiqi
authors.forename: S
authors.initials: S
authors.lastname: Khan
mesh_terms: D015152:Blotting, Northern; D016758:Genes, jun / Q000235:genetics*; D005865:Gestational Age; D006801:Humans; D010920:Placenta / Q000737:chemistry*; D010929:Placentation; D012313:RNA / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis*
chemical_list: D012333:RNA, Messenger; D012313:RNA