[The effect of a synthetic fragment of human interleukin-2 on the growth and vascularization of sarcoma 180 in mice].
The effect of a modified peptide of the middle part of the human interleukin-2 molecule (C-1-6) on the growth of transplantable sarcoma 180 of mice was studied. C-1-6 injected intraperitoneally in the dose of 0.5, 5 and 50 micrograms 4 times every other day was shown to stimulate tumor growth and enhance angiogenesis induced by the tumor transplanted intracutaneously. Stimulation of tumor growth was most apparent when the agent was given late (on day 4) after transplantation. Supernatants of murine peritoneal macrophages activated by 1 microgram/ml solution of C-1-6 proved capable of stimulating tumor growth, too. It is suggested that the stimulating effect of C-1-6 on tissue regeneration be investigated.
Ushmorov
A G
AG
Onoprienko
L V
LV
Voĭtenkov
B O
BO
Mikhaleva
I I
II
D000818:Animals; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000737:chemistry*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000139:chemically induced*; D010446:Peptide Fragments / Q000494:pharmacology*; D012510:Sarcoma 180 / Q000098:blood supply / Q000503:physiopathology*
D007376:Interleukin-2; D010446:Peptide Fragments
Vliianie sinteticheskogo fragmenta interleĭkina-2 cheloveka na rost i vaskuliarizatsiiu sarkomy 180 u mysheĭ.