Chronic administration of sublethal doses of carbaryl increases pineal N-acetyltransferase and hydroxyindole-O-methyltransferase activities and serum melatonin levels.
The purpose of this study was to examine the effects of chronic administration of sublethal doses of carbaryl on pineal melatonin synthesis. N-methyl 1-naphthylcarbamate (carbaryl) (8.33 mg/kg B.W. daily) was administered orally to adult male albino rats for 6 successive days. Nocturnal (0100) N-acetyltransferase and hydroxyindole-O-methyltransferase activities were increased (roughly 75% and 60%, respectively) by carbaryl administration; likewise, carbaryl augmented serum melatonin levels at 2300. Pineal tryptophan. 5-hydroxytryptophan, serotonin, and 5-hydroxindole acetic acid levels were unaffected at all three time points. The results indicate that the carbamate pesticide, i.e., carbaryl, modifies pineal melatonin synthesis in vivo.
Attia
A M
AM
Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio 78284-7762.
Reiter
R J
RJ
Withyachumnarnkul
B
B
Mostafa
M H
MH
Soliman
S A
SA
el-sebae
A K
AK
D006916:5-Hydroxytryptophan / Q000378:metabolism; D000121:Acetylserotonin O-Methyltransferase / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D001191:Arylamine N-Acetyltransferase / Q000378:metabolism*; D012721:Carbaryl / Q000008:administration & dosage / Q000633:toxicity*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000097:blood*; D010870:Pineal Gland / Q000187:drug effects* / Q000201:enzymology; D011863:Radioimmunoassay; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013223:Statistics as Topic; D014364:Tryptophan / Q000378:metabolism
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; D006916:5-Hydroxytryptophan; D000121:Acetylserotonin O-Methyltransferase; D001191:Arylamine N-Acetyltransferase; D008550:Melatonin; D012721:Carbaryl