Effect of prenatal ethanol exposure on postnatal neural gene expression in the rat.
To examine the effects of ethanol exposure on neural development, pregnant rats were fed a liquid diet in which 37.5% of the total caloric content was ethanol-derived. The developmental appearance of the messenger RNAs coding for preprosomatostatin, glial fibrillary acidic protein, and proteolipid protein was examined by Northern blotting of total cellular RNA obtained from forebrain and hindbrain at various times after birth. In general, there was a delay in the developmental pattern of appearance of these mRNAs which was most noticeable at the early postnatal times. These results suggest that the previously reported delay in neural maturation is reflected at the level of the gene expression.
Naus
C C
CC
Department of Anatomy, University of Western Ontario, London, Canada.
Bechberger
J F
JF
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics; D008431:Maternal-Fetal Exchange; D009185:Myelin Proteins / Q000235:genetics; D018991:Myelin Proteolipid Protein; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013004:Somatostatin / Q000235:genetics
D005904:Glial Fibrillary Acidic Protein; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D012333:RNA, Messenger; D000431:Ethanol; D013004:Somatostatin