[The extracorporeal immunostimulating effect of terrilytin in staphylococcal infection].
The intravenous injection of terrilytin-treated lymphocytes into rats infected with staphylococci enhances the formation of staphylococcal alpha antitoxin in the animals and the development of immune response to T-dependent antigen, such as sheep red blood cells (SRBC), but produces no effect on the development of immune response induced by T-independent antigen (lipopolysaccharide). Terrilytin-treated lymphocytes induce the release of the factor promoting the development of immune response to staphylococcal antigens and SRBC by spleen cells, incapable of adherence to plastic, but have no influence on the development of immune response to lipopolysaccharide in rats infected with staphylococci. At the same time in such rats spleen cells adhering to plastic take part in the transfer of signals from terrilytin-treated lymphocytes to nonadhering spleen cells of recipients.
Prokopenko
L G
LG
Bystrova
N A
NA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000681:Amylases / Q000627:therapeutic use*; D000818:Animals; D000992:Antitoxins / Q000097:blood / Q000187:drug effects; D001427:Bacterial Toxins / Q000276:immunology; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D002469:Cell Separation; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006460:Hemolysin Proteins / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology / Q000628:therapy*
D000276:Adjuvants, Immunologic; D000992:Antitoxins; D001427:Bacterial Toxins; D004338:Drug Combinations; D006460:Hemolysin Proteins; C021091:staphylococcal alpha-toxin; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases
Ekstrakorporal'nyĭ immunostimuliruiushchiĭ éffekt terrilitina pri stafilokokkovoĭ infektsii.