title: Reactivity of gastroepiploic and internal mammary arteries. Relevance to coronary artery bypass grafting.
abstract: The gastroepiploic artery is an alternate conduit for coronary artery bypass grafting. To test the hypothesis that its vasoreactive properties are different from those of the internal mammary artery, we obtained gastroepiploic artery segments from human gastrectomy specimens. Trimmed internal mammary artery segments were obtained during coronary artery bypass. Ring segments were mounted on a strain gauge and stretched to optimum resting length (90% of the internal circumference at 100 mm Hg). Potassium chloride, serotonin, and norepinephrine were chosen to simulate physiologic vasospasm induced by depolarization, platelet aggregation, or adrenergic stimulation, respectively. Contractions to potassium and a concentration-response curve to serotonin or norepinephrine were obtained. Sodium nitroprusside was used to assess relaxation. Gastroepiploic artery segments had stronger contractions to the depolarizing agent (potassium chloride), adrenergic stimulation (norepinephrine), and product of platelet aggregation (serotonin). The gastroepiploic and internal mammary arteries showed equal sensitivity, measured by concentration causing half-maximal contraction to norepinephrine and serotonin. There was no difference in relaxation to sodium nitroprusside. These data suggest that prevention of platelet-, adrenergic-, or potassium-induced contraction may be more important when the gastroepiploic artery is used as an alternate conduit for coronary artery bypass, reinforcing consideration of nitrovasodilators and platelet inhibitors in the perioperative interval.
authors.affiliation: Virginia Commonwealth University, Medical College of Virginia, Richmond 23298.
authors.forename: R J
authors.initials: RJ
authors.lastname: Dignan
authors.forename: T
authors.initials: T
authors.lastname: Yeh
authors.forename: C M
authors.initials: CM
authors.lastname: Dyke
authors.forename: K F
authors.initials: KF
authors.lastname: Lee
authors.forename: H A
authors.initials: HA
authors.lastname: Lutz
authors.forename: M
authors.initials: M
authors.lastname: Ding
authors.forename: A S
authors.initials: AS
authors.lastname: Wechsler
mesh_terms: D001158:Arteries / Q000187:drug effects / Q000502:physiology; D001026:Coronary Artery Bypass / Q000379:methods*; D006801:Humans; D008323:Mammary Arteries / Q000187:drug effects / Q000502:physiology*; D009599:Nitroprusside / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D009852:Omentum / Q000098:blood supply*; D011189:Potassium Chloride / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013270:Stomach / Q000098:blood supply*; D013314:Stress, Mechanical; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D009599:Nitroprusside; D012701:Serotonin; D011189:Potassium Chloride; D009638:Norepinephrine