title: [Production of virus-induced and mitogen-induced interferons by canine cells].
abstract: Cells of monocytic-phagocytic series and immunocompetent cells derived from dogs: bone marrow, leukocytes, spleen, thymus, lymph nodes (with the exception of the liver) were found to be capable of producing interferon (IFn) in vitro in response to inoculation of viral and non-viral inducers. This capacity is manifested in different ways: thymus and lymph node cells were less active interferon producers. Studies of physicochemical properties of the resulting interferons confirmed the belonging of the virus-induced IFn to alpha-interferons, PHA-induced IFn to immune alpha-IFn. The above-mentioned refers both to bone marrow and leukocyte interferons.
authors.forename: I I
authors.initials: II
authors.lastname: Georgadze
authors.forename: T G
authors.initials: TG
authors.lastname: Orlova
authors.forename: N V
authors.initials: NV
authors.lastname: Topuriia
authors.forename: M G
authors.initials: MG
authors.lastname: Agladze
authors.forename: R G
authors.initials: RG
authors.lastname: Togoshvili
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004285:Dogs; D007369:Interferon Inducers; D007372:Interferons / Q000032:analysis / Q000096:biosynthesis* / Q000187:drug effects / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology*; D009522:Newcastle disease virus / Q000187:drug effects / Q000472:pathogenicity; D010835:Phytohemagglutinins / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000472:pathogenicity
chemical_list: D007369:Interferon Inducers; D008934:Mitogens; D010835:Phytohemagglutinins; D007372:Interferons
vernacular_title: Produktsiia virusindutsirovannogo i mitogenindutsirovannogo interferonov kletkami sobak.