title: Opening the grey box.
abstract: The single neurone has been the guiding light for generations of neuroscientists. Now there are signs from experimental and theoretical work on the neocortex that we are on the threshold of a revolution in which the hegemony of the single neurone will be replaced by much more circuit-oriented concepts. We consider here why traditional views of the significance of single neurones are fading in power, and consider the problem of deciding on the form of a new order.
authors.affiliation: MRC Anatomical Neuropharmacology Unit, Dept of Pharmacology, Oxford, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Douglas
authors.forename: K A
authors.initials: KA
authors.lastname: Martin
mesh_terms: D000200:Action Potentials; D000818:Animals; D001185:Artificial Intelligence; D003712:Dendrites / Q000502:physiology; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D009482:Neurophysiology / Q000379:methods / Q000639:trends*; D009435:Synaptic Transmission; D013788:Thalamus / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*; D014795:Visual Pathways / Q000502:physiology*