title: Enalapril, an inhibitor of angiotensin converting enzyme, increases the junctional conductance in isolated heart cell pairs.
abstract: The effect of enalapril and angiotensin II on junctional conductance (gj) of isolated rat heart cell pairs was investigated. It was found that enalapril (1 micrograms/ml) increases gj by 106 +/- 3.1% (SEM) (n = 20) within 4 min. The effect of enalapril on gj was not suppressed by propranolol (10(-6) M) or by a cAMP-dependent protein kinase inhibitor. Angiotensin II (1 micrograms/ml) reduced gj by 55%. These observations might indicate that an intrinsic renin-angiotensin system in heart is involved in the control of gj in cardiac muscle.
authors.affiliation: Department of Pharmacology, Medical Sciences Campus, UPR, San Juan 00936.
authors.forename: W C
authors.initials: WC
authors.lastname: De Mello
authors.forename: P
authors.initials: P
authors.lastname: Altieri
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D004656:Enalapril / Q000494:pharmacology*; D006329:Heart Conduction System / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009206:Myocardium / Q000166:cytology; D009469:Neuromuscular Junction / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D047428:Protein Kinase Inhibitors; D051381:Rats; D012084:Renin-Angiotensin System / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D047428:Protein Kinase Inhibitors; D000804:Angiotensin II; D004656:Enalapril; D011433:Propranolol; D000242:Cyclic AMP