title: [Prolonged erythrocytic T activation, depression of blood group A and increase of fetal hemoglobin in a myelodysplastic syndrome evolving into erythroleukemia].
abstract: T cryptantigen can be exposed on the red cell membrane as a result of removal of terminal glycosides, either by bacterial enzymes or by incomplete synthesis of the cell membrane due to somatic mutation, usually caused by a neoplasm. T-activated erythrocytes have been observed in different pathologies, but they have not been seen associated with other abnormalities of red blood cell proteins described in myelodysplastic syndromes or acute leukaemias. A patient with initial diagnosis of refractory anaemia that evolved into erythroleukaemia showed prolonged T-activation, a depressed A blood-group antigen and an increase of foetal haemoglobin, simultaneously. The evolutive pattern of T-activation suggests more an abnormal erythropoiesis than an enzymatic effect and a certain relationship with the haemolytic syndrome.
authors.affiliation: Hospital Nacional Profesor Alejandro Posadas, Servicio de Hematología, Buenos Aires, Argentina.
authors.forename: O N
authors.initials: ON
authors.lastname: Gioseffi
authors.forename: F
authors.initials: F
authors.lastname: Del Río
authors.forename: P
authors.initials: P
authors.lastname: Pardini
authors.forename: M
authors.initials: M
authors.lastname: Kitagawa
mesh_terms: D000017:ABO Blood-Group System; D000753:Anemia, Refractory / Q000097:blood* / Q000473:pathology; D000951:Antigens, Neoplasm / Q000032:analysis; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides / Q000032:analysis*; D004920:Erythropoiesis; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis*; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D011289:Preleukemia / Q000097:blood
chemical_list: D000017:ABO Blood-Group System; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D004187:Disaccharides; C016467:Thomsen-Friedenreich antigen; D005319:Fetal Hemoglobin
vernacular_title: Activación T eritrocítica prolongada, debilitamiento de grupo sanguíneo A y aumento de hemoglobina fetal en un síndrome mielodisplásico con evolución a eritroleucemia.