Effects of cefroxadine on L-leucine absorption in rat jejunum.
The effect of cefroxadine, an aminocephalosporin (beta lactam antibiotic) on rat intestinal L-leucine transport has been studied. Cefroxadine inhibited the L-leucine uptake by the intestinal mucosa in a dose-dependent fashion. In vivo studies showed that cefroxadine reduced L-leucine absorption. This effect was irreversible. Only the active transport component of the absorption was inhibited. Oxygen consumption of the mucosa was reduced by cefroxadine which inhibited the activity of the basolateral (Na(+)-K+) ATPase also.
Mendizabal
M V
MV
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
Idoate
I
I
Jordan
J
J
Larralde
J
J
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002515:Cephradine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D007930:Leucine / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
C012671:cefroxadine; D000254:Sodium-Potassium-Exchanging ATPase; D002515:Cephradine; D007930:Leucine