Demonstration of amyloid beta-protein in a 32-year-old man with progressive dementia.
We report the immunolocalization of extensive amyloid beta-protein in senile plaques, cerebrovascular amyloid deposits, neurofibrillary tangles and preamyloid in a 32-year-old man with progressive dementia not due to trisomy 21 or trauma. These amyloid deposits were non-reactive to antibodies directed against scrapie amyloid. Our data indicate that the presence of amyloid beta-protein is not limited to normal aging, Alzheimer's disease and related disorders but is also found in younger individuals with progressive dementia.
Guiroy
D C
DC
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
Liberski
P P
PP
Alwasiak
J
J
Papierz
W
W
Gajdusek
D C
DC
D000328:Adult; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D001718:Birefringence; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002531:Cerebellum / Q000378:metabolism; D003704:Dementia / Q000378:metabolism* / Q000473:pathology / Q000523:psychology; D006801:Humans; D007158:Immunologic Techniques; D008297:Male; D013194:Staining and Labeling
D016229:Amyloid beta-Peptides