title: prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila.
abstract: Neurogenesis in Drosophila begins with the formation of neuronal precursors, which give rise to neurons of individual identity. To find out whether there are genes that are expressed in most or all neuronal precursors and are involved in controlling particular aspects of neuronal differentiation, we used the enhancer-trap method to screen for such "neuronal precursor genes." One gene of this group is prospero. Our mutant analysis indicates that prospero regulates other neuronal precursor genes and is essential for the axonal outgrowth and pathfinding of numerous central and peripheral neurons. prospero encodes a large nuclear protein with multiple homopolymeric amino acid stretches and is expressed in neuronal precursors early during their formation. It is probably generally required for proper neuronal differentiation.
authors.affiliation: Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.
authors.forename: H
authors.initials: H
authors.lastname: Vaessin
authors.forename: E
authors.initials: E
authors.lastname: Grell
authors.forename: E
authors.initials: E
authors.lastname: Wolff
authors.forename: E
authors.initials: E
authors.lastname: Bier
authors.forename: L Y
authors.initials: LY
authors.lastname: Jan
authors.forename: Y N
authors.initials: YN
authors.lastname: Jan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies; D001369:Axons / Q000502:physiology*; D001483:Base Sequence; D003001:Cloning, Molecular; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000502:physiology; D005796:Genes; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009687:Nuclear Proteins / Q000235:genetics*; D010455:Peptides / Q000138:chemical synthesis / Q000276:immunology; D016133:Polymerase Chain Reaction; D011498:Protein Precursors / Q000235:genetics*; D012313:RNA / Q000235:genetics; D015183:Restriction Mapping; D014158:Transcription, Genetic
chemical_list: D000906:Antibodies; D009687:Nuclear Proteins; D010455:Peptides; D011498:Protein Precursors; D012313:RNA