title: Recombinant derivatives of Pasteurella multocida toxin: candidates for a vaccine against progressive atrophic rhinitis.
abstract: Potential vaccine components for protection against atrophic rhinitis in pigs were developed. This was achieved by deletion mutagenesis of the gene encoding the Pasteurella multocida toxin. Four purified toxin derivatives lacking different and widely separated regions in the amino acid sequence were characterized by a lack of toxic activity. One such component was shown to induce efficient protection of vaccinated female mice and their offspring against challenge with purified P. multocida toxin.
authors.affiliation: Genetic Engineering Group, Technical University of Denmark, Lyngby.
authors.forename: S K
authors.initials: SK
authors.lastname: Petersen
authors.forename: N T
authors.initials: NT
authors.lastname: Foged
authors.forename: A
authors.initials: A
authors.lastname: Bording
authors.forename: J P
authors.initials: JP
authors.lastname: Nielsen
authors.forename: H K
authors.initials: HK
authors.lastname: Riemann
authors.forename: P L
authors.initials: PL
authors.lastname: Frandsen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology*; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D002872:Chromosome Deletion; D000939:Epitopes / Q000032:analysis; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010325:Pasteurella / Q000276:immunology*; D012222:Rhinitis, Atrophic / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D013329:Structure-Activity Relationship; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D001428:Bacterial Vaccines; D000939:Epitopes; C062258:Pasteurella multocida toxin; D014614:Vaccines, Synthetic