title: Dipole source localization in the study of EP generators: a critique.
abstract: (1) The decision to solve the inverse problem in terms of one or more localized generators implies the assumption of a particular generator model. This assumption permits carrying out inverse dipole estimation. However, it is perilous to justify the procedure on the basis of the result. (2) Goodness of fit is a necessary but not sufficient criterion of model adequacy. A particular quantitative inverse solution has meaning only if it is accompanied by consideration of sensitivity to small changes in all of the free modeling parameters and estimates of perturbing factors including noise and forward calculation uncertainties.
authors.affiliation: Washington University School of Medicine, Department of Neurology and Neurological Surgery, St. Louis, MO 63110.
authors.forename: A Z
authors.initials: AZ
authors.lastname: Snyder
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D008954:Models, Biological