[Effect of tranilast (N-5) on cellular immunity--delayed type hypersensitivity].
Tranilast (N-5) as a mast-cell stabilizer is widely used in cases of bronchial asthma and nasal allergy. Some reports showed that N-5 is effective against keloids and ulcerative colitis. So, it is considered that N-5 inhibits cell-mediated immunity. N-5 inhibited BCG-CWS-stimulated lymphocyte proliferation which was proved to be mainly operated by OKT4 positive T cells. Production of the lymphokine from BCG-CWS-stimulated lymphocytes was suppressed by the addition of N-5. Thus, it is demonstrated that N-5 inhibits delayed type hypersensitivity in vitro.
Osabe
M
M
Second Department of Internal Medicine, Nagasaki University School of Medicine.
D006801:Humans; D006968:Hypersensitivity, Delayed / Q000517:prevention & control*; D007111:Immunity, Cellular / Q000187:drug effects*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects*; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
D062367:ortho-Aminobenzoates; C012293:tranilast