The effects of enalapril and sulindac on the dermal response to substance P and neurokinin A.
The effects of pretreatment with enalapril, and sulindac, on the weal response to intradermal injections of substance P and neurokinin A were assessed in a randomised, double-blind, placebo-controlled study. Weal responses to both substance P and neurokinin A depended significantly on dose. Neither enalapril nor sulindac, nor the combination of these agents influenced the responses to either tachykinin. These results do not suggest any role for substance P or neurokinin A in the clinical effects of angiotensin converting enzyme inhibitors.
Ferner
R E
RE
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne.
Kamali
F
F
Rawlins
M D
MD
D000328:Adult; D004311:Double-Blind Method; D004656:Enalapril / Q000494:pharmacology*; D006801:Humans; D008297:Male; D015288:Neurokinin A / Q000494:pharmacology*; D011897:Random Allocation; D012867:Skin / Q000187:drug effects*; D012882:Skin Tests; D013373:Substance P / Q000494:pharmacology*; D013467:Sulindac / Q000494:pharmacology*
D013467:Sulindac; D013373:Substance P; D004656:Enalapril; D015288:Neurokinin A