title: Autoantibodies against the beta-adrenergic receptor in human myocarditis and dilated cardiomyopathy: beta-adrenergic agonism without desensitization.
abstract: The serum of patients with myocarditis and dilated cardiomyopathy contains immunoglobulins capable of causing in vitro acceleration of beating of neonatal rat heart myocytes. This effect is stereoselectively inhibited by (-)-propranolol and is inhibited also by the beta 1-selective adrenergic antagonists, bisoprolol and metoprolol. This effect is not reversed by washing and continues unabated for at least 24 h.
authors.affiliation: Institut für Herz-Kreislauf-Forschung, Berlin-Buch, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Wallukat
authors.forename: M
authors.initials: M
authors.lastname: Morwinski
authors.forename: K
authors.initials: K
authors.lastname: Kowal
authors.forename: A
authors.initials: A
authors.lastname: Förster
authors.forename: V
authors.initials: V
authors.lastname: Boewer
authors.forename: A
authors.initials: A
authors.lastname: Wollenberger
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002311:Cardiomyopathy, Dilated / Q000276:immunology* / Q000473:pathology; D002478:Cells, Cultured; D003888:Desensitization, Immunologic; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009205:Myocarditis / Q000276:immunology* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000276:immunology*; D005719:gamma-Globulins / Q000494:pharmacology
chemical_list: D000319:Adrenergic beta-Antagonists; D001323:Autoantibodies; D011943:Receptors, Adrenergic, beta; D005719:gamma-Globulins