title: Anti-allergic effect of N-acetylneuraminic acid in guinea-pigs.
abstract: The in-vivo anti-allergic effect of N-acetylneuraminic acid (NANA) in guinea-pigs passively sensitized with anti-ovalbumin rabbit serum has been studied. NANA (20 mg kg-1 i.v.) inhibited bronchial anaphylaxis and the release of histamine into bronchoalveolar lavage fluid. NANA dose-dependently inhibited heterologous passive cutaneous anaphylaxis and haemorrhaging in the passive Arthus reaction. However, it did not inhibit the release of histamine from sensitized minced lung tissue.
authors.affiliation: Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kai
authors.forename: Y
authors.initials: Y
authors.lastname: Murata
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: S
authors.initials: S
authors.lastname: Nishijima
authors.forename: K
authors.initials: K
authors.lastname: Murahara
authors.forename: S
authors.initials: S
authors.lastname: Ogasawara
authors.forename: N
authors.initials: N
authors.lastname: Sugiyama
authors.forename: K
authors.initials: K
authors.lastname: Takahama
authors.forename: T
authors.initials: T
authors.lastname: Miyata
mesh_terms: D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D001985:Bronchial Provocation Tests; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D019158:N-Acetylneuraminic Acid; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D012794:Sialic Acids / Q000627:therapeutic use*
chemical_list: D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid