Background genes mediate the development of autoimmunity in (NZB x PL/J)F1 or (NZB x BIO.PL)F1 mice.
The (NZB x NZW)F1 mouse develops a lupus-like disease including anti-double-stranded DNA antibodies and renal disease. It has been demonstrated that genes linked to the H-2 locus contributed by NZW correlate with development of this disease. We investigated whether mice with identical class II molecules but different background genes could contribute to autoimmunity when crossed with NZB. We report that two strains, PL/J and BIO.PL, when crossed to NZB, do not result in F1 with autoimmunity. Therefore, background genes present in NZW but not in PL/J or BIO.PL contribute to the development of disease.
Schiffenbauer
J
J
Department of Medicine, University of Florida College of Medicine, Gainesville 32610.
Wegrzyn
L
L
Croker
B P
BP
D000595:Amino Acid Sequence; D000818:Animals; D015551:Autoimmunity / Q000235:genetics*; D001483:Base Sequence; D005091:Exons; D005260:Female; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D008180:Lupus Erythematosus, Systemic / Q000473:pathology; D008181:Lupus Nephritis / Q000473:pathology; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics*; D008969:Molecular Sequence Data
D006183:H-2 Antigens