title: Formation of nerve twig-like nests and schwannoma in an unusual case of neurofibroma.
abstract: A case of unusual neurofibroma in an 18-year-old Japanese male is reported. The histology of the tumor was characterized by nerve twig-like nests intermingled with fascicular bundles. In the central portion, the tumor also contained a lobular lesion showing features characteristic of schwannoma. Immunohistochemically, the tumor cells in both the nests and the lobular lesion demonstrated a mostly positive reaction for S-100 protein. S-100 protein-positive and -negative cells were observed in equal numbers in the fascicular bundles surrounding the nests. This unusual nerve sheath tumor in which the S-100 protein-positive cells form both nerve twig-like nests and lobular schwannoma has not been reported previously. The origin of the S-100 protein-positive cells in the two lesions is also discussed.
authors.affiliation: Department of Pathology and Oncology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Suenaga
authors.forename: S
authors.initials: S
authors.lastname: Imayama
authors.forename: A
authors.initials: A
authors.lastname: Horie
mesh_terms: D000293:Adolescent; D000943:Antigens, Differentiation / Q000378:metabolism; D018959:CD57 Antigens; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D018396:Mucin-1; D009380:Neoplasms, Nerve Tissue / Q000378:metabolism / Q000473:pathology*; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology*; D009455:Neurofibroma / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D000943:Antigens, Differentiation; D018959:CD57 Antigens; D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D018396:Mucin-1; D009418:S100 Proteins