[Large cell anaplastic lymphomas in the immunocompromised host].
Large cell anaplastic (LCA) lymphomas are a newly defined tumor entity, which has recently been integrated in the updated Kiel classification. The occurrence of CD30+ LCA lymphoma in the setting of renal transplant patients has so far been reported only once. This report describes two LCA lymphomas of B-cell phenotype in renal transplant patients. The clonal evolution and possible etiologic role of Epstein-Barr Virus (EBV) in LCA lymphoma was studied. Our findings give further evidence that clonal evolution of B-cell populations is a second event in lymphomagenesis and is, at least in the cases studied, preceeded by either reactivated latent or primary EBV-infection with clonal EBV proliferation.
Borisch
B
B
Pathologisches Institut, Universität Bern.
Fey
M F
MF
Tobler
A
A
Bürki
K
K
Gatter
K C
KC
Wainscoat
J S
JS
D015703:Antigens, CD / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D001344:Autopsy; D001706:Biopsy; D015139:Blotting, Southern; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D006566:Herpesviridae Infections / Q000150:complications / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D017730:Ki-1 Antigen; D016030:Kidney Transplantation / Q000276:immunology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D015183:Restriction Mapping
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D004279:DNA, Viral; D017730:Ki-1 Antigen
Grosszellige anaplastische Lymphome bei Immunsuppression.