title: Acidic fibroblast growth factor (aFGF) is present in the fluid of brain tumour pseudocysts.
abstract: Fluid samples from brain tumour pseudocysts were examined for the presence of Fibroblast Growth Factor (FGF). Fluids were collected from 6 patients with differentiated low grade gliomas (group A), 3 anaplastic gliomas (group B) and 3 metastases (group C). For FGF assays pooled fluids from group A, B, and C were subjected to affinity chromatography on a Heparin-Sepharose column. Each pool contained endothelial cell mitogenic activity which eluted in the 1.2 M NaCl fraction and to a lesser degree in the 0.6 M fraction of Heparin-Sepharose high affinity chromatography. Mitogenic activity in the 1.2 M NaCl fraction of Heparin-Sepharose chromatography suggests the presence of acidic FGF (aFGF).
authors.affiliation: Department of Stereotaxic Neurosurgery, Saarland University, Homburg, Federal Republic of Germany.
authors.forename: J R
authors.initials: JR
authors.lastname: Moringlane
authors.forename: R
authors.initials: R
authors.lastname: Spinas
authors.forename: P
authors.initials: P
authors.lastname: Böhlen
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000737:chemistry* / Q000601:surgery; D002417:Cattle; D002455:Cell Division / Q000502:physiology*; D002460:Cell Line; D002846:Chromatography, Affinity; D004730:Endothelium, Vascular / Q000473:pathology; D016220:Fibroblast Growth Factor 1 / Q000032:analysis*; D005910:Glioma / Q000737:chemistry* / Q000601:surgery; D006801:Humans
chemical_list: D016220:Fibroblast Growth Factor 1