[Peptide synthesis--protein fragments from Plasmodium falciparum and their conjugates with protein and synthetic carriers].
To study coat proteins of Plasmodium falciparum, seven putative antigenic-determinants of PMMSA, SHARP, GBP and four known determinants of CSP, CRA and RESA were synthesized. Computerized methods for predicting protein antigenic determinants were employed to select the peptides. For immunochemical studies the peptides were conjugated to proteins and synthetic carriers by means of nonspecific and regiospecific heterobifunctional reagents.
Ivanov
B B
BB
Iurovskiĭ
V V
VV
Tertyshnikova
S M
SM
Andronova
T M
TM
Ivanov
V T
VT
D000595:Amino Acid Sequence; D000818:Animals; D003432:Cross-Linking Reagents; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis*; D010963:Plasmodium falciparum / Q000378:metabolism*; D015800:Protozoan Proteins / Q000737:chemistry* / Q000276:immunology
D003432:Cross-Linking Reagents; D000939:Epitopes; D010446:Peptide Fragments; D015800:Protozoan Proteins
Sintez peptidov--fragmentov belkov Plazmodium falciparum i ikh kon''iugatov s belkovymi i sinteticheskimi nositeliami.