[The behavior of substance P concentration in rat plasma in the acute single- and combined-actions of trichloroethylene and ethanol].
In experimental studies in male Wistar-rats exerted for determination of trichloroethylene, ethanol and combined action influences on the substance P plasma concentrations. These concentrations were determined by a radioimmunological method. The acute exposure of trichloroethylene and ethanol lead to a significant rise of substance P. We found high substance P concentration peaks, in principle, 4 h after acute exposure and the combined action shows the greatest effect.
Fendius
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RR
Zentralinstitut für Arbeitsmedizin, Klinik und Poliklinik für Berufskrankheiten, Akademie für Arztliche Fortbildung.
Gutewort
T
T
Hinz
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G
D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000097:blood*; D014241:Trichloroethylene / Q000494:pharmacology*
D014241:Trichloroethylene; D013373:Substance P; D000431:Ethanol
Das Verhalten der Substanz P-Konzentration im Rattenplasma unter akuter Einzel- und kombinierter Einwirkung von Trichlorethylen und Ethanol.