title: Disposition of an antineoplastic sesquiterpene lactone, [3H]-plenolin, in BDF1 mice.
abstract: The pharmacokinetics of a radiolabelled analog of helenalin, [3H]-plenolin ([3H]-11,13-dihydrohelenalin), was determined in BDF1 mice following intravenous, intraperitoneal, and oral administration. A two-compartment pharmacokinetic model predicted that the maximum terminal (beta) half-life of [3H]-plenolin was 57.3 hours. Urinary excretion accounted for 40.3% to 64.4% of the administered radioactivity, while fecal excretion accounted for 9.3% to 39.7%. The fecal excretion data also suggested that [3H]-plenolin was secreted in the bile. Following intraperitoneal administration of [3H]-plenolin, no radioactivity was sequestered in the major organs. However, radioactivity was sustained in the carcass and skin for 24 days. [3H]-Plenolin was rapidly taken up by murine tumor cells and human fibroblasts. The drug did not significantly associate with DNA, RNA, or protein of P388 leukemia or human fibroblast cells.
authors.affiliation: Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
authors.forename: A A
authors.initials: AA
authors.lastname: Grippo
authors.forename: S D
authors.initials: SD
authors.lastname: Wyrick
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: R P
authors.initials: RP
authors.lastname: Shrewsbury
authors.forename: I H
authors.initials: IH
authors.lastname: Hall
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics*; D004273:DNA, Neoplasm / Q000378:metabolism; D006801:Humans; D007941:Leukemia P388 / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D015394:Molecular Structure; D012313:RNA / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism; D012717:Sesquiterpenes / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004273:DNA, Neoplasm; D012717:Sesquiterpenes; D012710:Serum Albumin, Bovine; C026745:plenolin; D012313:RNA