HMB-45-positive malignant lymphoma. A case report with literature review of aberrant HMB-45 reactivity.
The monoclonal antibody HMB-45 is a highly specific and sensitive marker of malignant melanoma. Rarely, however, aberrant reactivity to nonmelanocytic tumors has been observed. We report an immunoblastic lymphoma of B-cell phenotype that reacted with HMB-45 in a 70-year-old white woman. To our knowledge, this is the first report of HMB-45-positive malignant lymphoma (excluding plasmacytoma). Of an additional 13 cases of benign and malignant lymphoid tissue, only benign plasma cells in one case reacted with HMB-45.
Friedman
H D
HD
Department of Pathology, State University of New York Health Science Center, Syracuse.
Tatum
A H
AH
D000368:Aged; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008223:Lymphoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008854:Microscopy, Electron; D013194:Staining and Labeling
D000911:Antibodies, Monoclonal