title: Pulmonary edema and coagulopathy following intrauterine instillation of 32% dextran-70 (Hyskon).
abstract: Hysteroscopy using 32% Dextran-70 in 10% dextrose (Hyskon) is a common outpatient procedure. We report a case of pulmonary edema and coagulopathy in a 38-year-old, 48 kg female who had hysteroscopy and removal of an endocervical polyp using 700 ml of Hyskon over a 2-hour period. Low percutaneous oxygen saturation (SpO2) and vaginal bleeding developed postoperatively. A vaginal hysterectomy was performed. The coagulation profile showed coagulopathy, which was treated with transfusions of fresh frozen plasma and platelets. The patient developed overt pulmonary edema following the hysterectomy and was treated with positive pressure ventilation. The pathophysiology for the development of pulmonary edema and coagulopathy is discussed. Recommended limits for Hyskon volumes and instillation times are emphasized, as is careful recording of these parameters.
authors.affiliation: Department of General Anesthesiology, Cleveland Clinic Foundation, OH 44195-5154.
authors.forename: M J
authors.initials: MJ
authors.lastname: Choban
authors.forename: S B
authors.initials: SB
authors.lastname: Kalhan
authors.forename: R J
authors.initials: RJ
authors.lastname: Anderson
authors.forename: R
authors.initials: R
authors.lastname: Collins
mesh_terms: D000328:Adult; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007322:Instillation, Drug; D011654:Pulmonary Edema / Q000139:chemically induced*; D014599:Uterus
chemical_list: D003911:Dextrans