Modification of cyclocytidine-induced changes in [3H]thymidine incorporation and weight of parotid gland by partial sialoadenectomy.
Cyclocytidine (CC), a potent antitumor agent, caused a 2.3- to 5.0-fold increase in [3H]thymidine uptake of rat parotid gland after 3 days of daily administration of 500 mg/kg body wt. Gland weight also showed a 47-67% increase from that of controls. Ablation of the submandibular-sublingual glands prior to initiation of the CC regimen prevented the usual CC-induced increase in [3H]thymidine uptake, but did not inhibit the increase in gland size. It is postulated that CC-induced parotid hyperplasia requires an initial release of growth factors from the submandibular gland; however, enlargement of the parotid gland by CC is independent of such factors.
Schneyer
C A
CA
Laboratory of Exocrine Physiology, University of Alabama, Birmingham 35294.
Hall
H D
HD
Humphreys-Beher
M G
MG
D003504:Ancitabine / Q000494:pharmacology*; D000818:Animals; D006965:Hyperplasia; D009638:Norepinephrine / Q000032:analysis; D009929:Organ Size / Q000187:drug effects; D010306:Parotid Gland / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D013361:Sublingual Gland / Q000502:physiology*; D013363:Submandibular Gland / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism*
D003504:Ancitabine; D013936:Thymidine; D009638:Norepinephrine