Mechanisms of ventricular arrhythmias.
Ventricular arrhythmias may result from abnormalities of impulse initiation and/or impulse propagation. The former include automatic arrhythmias, which may occur at high (normal) levels of membrane potential or at low (abnormal) levels of membrane potential. They also include triggered activity, which may result from early (occurring before complete repolarization) or delayed (occurring after complete repolarization) afterdepolarizations. Arrhythmias resulting from abnormal impulse propagation may be reentrant, determined in part by anatomic or functional conduction block, or the result of reflection. The factors determining various arrhythmogenic mechanisms are discussed.
Binah
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Department of Physiology and Biophysics, Faculty of Medicine, The Technion, Haifa, Israel.
Rosen
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MR
D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D004594:Electrophysiology; D006321:Heart / Q000503:physiopathology; D006329:Heart Conduction System / Q000502:physiology / Q000503:physiopathology; D006352:Heart Ventricles; D006801:Humans; D008955:Models, Cardiovascular; D012016:Reference Values