Enhanced resistance against Listeria monocytogenes achieved by pretreatment with granulocyte colony-stimulating factor.
Phagocytosis, H2O2 production, Mac-1 expression, and in vivo elimination of Listeria monocytogenes were enhanced in granulocyte colony-stimulating factor (G-CSF)-treated mice. Transfer of polymorphonuclear leukocytes prolonged survival of mice infected with a lethal dose of L. monocytogenes. G-CSF augments the functions of polymorphonuclear leukocytes and thus plays a role in protection.
Shinomiya
N
N
Department of Microbiology, National Defense Medical College, Saitama, Japan.
Tsuru
S
S
Katsura
Y
Y
Kayashima
S
S
Nomoto
K
K
D000818:Animals; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D008088:Listeriosis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor