Influence of MHC genes on spontaneous recovery from Friend retrovirus-induced leukemia.
Genes influencing the rate of spontaneous recovery from erythroleukemia induced by a low dose of Friend virus complex were located in the right and left portions of the mouse MHC. The right side gene was most likely the previously described Rfv-1 in the H-2D region. Using the B6.C-H-2bm12 mutant mice, the left side gene was mapped to the A beta class II locus. The A beta b was a resistant allele and A beta k and A beta bm12 were susceptible alleles. Genes at this class II locus controlled the responsiveness of Th cells to envelope glycoprotein of Friend murine leukemia helper virus and affected the class switching of virus-neutralizing antibodies from IgM to IgG in FV-infected mice.
Miyazawa
M
M
Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, MT 59840.
Nishio
J
J
Wehrly
K
K
Chesebro
B
B
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D005622:Friend murine leukemia virus / Q000276:immunology*; D015750:Genes, gag; D006183:H-2 Antigens / Q000235:genetics*; D006239:Haplotypes; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D009365:Neoplasm Regression, Spontaneous; D013163:Splenomegaly / Q000276:immunology
D000914:Antibodies, Viral; D006183:H-2 Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M