Different types of antigen-presenting cells affect the induction of experimental autoimmune arthritis.
We obtained a type II collagen-specific murine T cell line containing at least two T cell clones, one reacting with only native collagen II and the other with both denatured and native molecules. Only the former could induce arthritis. The arthritogenic T cell clone(s) was preferentially stimulated to grow when epidermal cells were used as antigen-presenting cells. Conversely, the non-arthritogenic T cell clone(s) was mainly stimulated when spleen cells were used. Thus, it is speculated that different types of antigen-presenting cells preferentially present different epitopes on the same antigen, affecting the resulting in vivo immune phenomena.
Kakimoto
K
K
Department of Biochemistry, Kumamoto University Medical School, Japan.
Koga
T
T
Onoue
K
K
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001168:Arthritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D002460:Cell Line; D003094:Collagen / Q000737:chemistry / Q000276:immunology; D000078404:Epidermal Cells; D004817:Epidermis / Q000276:immunology; D000939:Epitopes; D008213:Lymphocyte Activation; D051379:Mice; D008811:Mice, Inbred DBA; D011489:Protein Denaturation; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D003094:Collagen