Electrophysiologic mechanisms of ventricular arrhythmias.
In this work the electrophysiologic mechanisms of ventricular arrhythmias have been briefly summarized. Ventricular arrhythmias can be caused either by pacemaker activity or by reentrant excitation. Enhancement of normal automaticity can generate a parasystolic rhythm in normal fibers. Abnormal automaticity may arise from fibers in which maximum diastolic potential has been reduced by a variety of interventions. Triggered activity is caused by either an early (EAD) or delayed (DAD) afterdepolarization and requires a prior normal action potential for initiation. While there is growing evidence that EAD-induced triggered activity plays a significant role in the Long QTU syndrome and Torsade de Pointes, no clinical arrhythmias has definitely been ascribed to DADs, although DADs have been recorded in man after acute digoxin intoxication. Ventricular arrhythmias can be also caused by reentrant excitation, which can be subdivided into reflection or circus movement reentry (CMR). In the reflection model impulses in both directions are transmitted over the same pathway. In the CMR three models can be differentiated: the ring model, which requires a fixed anatomical obstacle; the figure-eight model and the leading circle model, where functional rather than fixed anatomical obstacles are involved.
el-Sherif
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Department of Medicine, State University of New York Health Science Center, Brooklyn.
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D005117:Cardiac Complexes, Premature / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008955:Models, Cardiovascular; D011690:Purkinje Fibers / Q000503:physiopathology; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016171:Torsades de Pointes / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology