Dorsal hippocampal lesion abolishes the response to FG-7142 in the rat.
The effects of the anxiogenic beta-carboline FG-7142 (15 mg/kg IP) on exploratory locomotor activity were assessed in rats with sham or ibotenic acid (IA) lesions of the dorsal or ventral hippocampus. FG-7142 reduced exploratory activity similarly in control animals as well as in those with IA lesions of the ventral hippocampus. In contrast, FG-7142 had no effect on rats with dorsal hippocampal lesions. The results suggest that the dorsal hippocampus plays a unique role in FG-7142-mediated attenuation of locomotor exploration. Other studies suggest that serotonergic systems may mediate these properties of FG-7142.
Lipska
B K
BK
Clinical Brain Disorders Branch, National Institutes of Mental Health Neuroscience Center at St. Elizabeths, Washington, DC 20032.
Jaskiw
G E
GE
Weinberger
D R
DR
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D007051:Ibotenic Acid / Q000633:toxicity; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling
D002243:Carbolines; D007051:Ibotenic Acid; C035874:FG 7142