title: True histiocytic neoplasm of Langerhans' cell type.
abstract: Malignant histiocytic neoplasms of dendritic cell lineage are rare and most are derived from the dendritic cells of the T-cell and B-cell areas of the lymph node, respectively. Only one case of a malignant histiocytic neoplasm of Langerhans' cells, the dendritic cell of the skin, has been reported. We report the occurrence of a true histiocytic neoplasm of Langerhans' cell type in a 23-year-old female patient. The diagnosis of this highly aggressive neoplasm is supported by histochemical, immunohistochemical, ultrastructural, and genotypic analysis--techniques which allow differentiation from malignant melanoma and large cell anaplastic lymphoma.
authors.affiliation: Department of Pathology II, University Hospital, K.U. Leuven, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Delabie
authors.forename: C
authors.initials: C
authors.lastname: De Wolf-Peeters
authors.forename: R
authors.initials: R
authors.lastname: De Vos
authors.forename: E
authors.initials: E
authors.lastname: Vandenberghe
authors.forename: K
authors.initials: K
authors.lastname: Kennes
authors.forename: I
authors.initials: I
authors.lastname: De Jonge
authors.forename: V
authors.initials: V
authors.lastname: Desmet
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D013194:Staining and Labeling
chemical_list: D000951:Antigens, Neoplasm