title: Protein glycation: effects upon protein recognition by the proximal tubule.
abstract: Reabsorption of 125I labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different explanations considered, we think molecular charge of the protein seems to be a key factor for the altered recognition of glycated albumin by the proximal tubule.
authors.affiliation: Life Sciences Division, Los Alamos National Laboratory, University of California, New Mexico 87545.
authors.forename: A
authors.initials: A
authors.lastname: Kowluru
authors.forename: R A
authors.initials: RA
authors.lastname: Kowluru
authors.forename: S
authors.initials: S
authors.lastname: Solomon
authors.forename: L
authors.initials: L
authors.lastname: Martinez
mesh_terms: D000818:Animals; D001692:Biological Transport; D017127:Glycation End Products, Advanced; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D000093423:Glycated Serum Albumin
chemical_list: D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin