title: [Normal immune function in centroblastic-centrocytic and centroblastic lymphoma].
abstract: We tested in vitro lymphocyte reactivity using 5 mitogens and 9 antigens, measured lymphocyte and lymphocyte subpopulation counts, granulocyte chemotaxis and adherence in 10 patients with centroblastic-centrocytic lymphoma (CB-CC), 7 patients with centroblastoma (CB) and 88 healthy controls. The control group could be divided into 3 clusters with significantly different lymphocyte reactivity by means of cluster and discrimination analysis (BMDP2N): 21 high-, 18 medium- and 49 low responders. Comparing lymphocyte reactivity of CB-CC and CB patients to each of the 3 immunofunctional different control groups yielded the surprising result that both malignant lymphomas are equivalent to the low responding control group and show a low, but still normal in vitro immune function.
authors.affiliation: Abteilung Innere Medizin, Universitätsklinikum Rudolf Vierchow-Standort Charlottenburg, Freie Universität Berlin.
authors.forename: V
authors.initials: V
authors.lastname: Weisbach
authors.forename: T
authors.initials: T
authors.lastname: Zeiler
authors.forename: J
authors.initials: J
authors.lastname: Zingsem
authors.forename: H G
authors.initials: HG
authors.lastname: Heuft
authors.forename: W
authors.initials: W
authors.lastname: Mempel
authors.forename: W
authors.initials: W
authors.lastname: Wilmanns
authors.forename: R
authors.initials: R
authors.lastname: Eckstein
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
vernacular_title: Normale Immunfunktion bei zentroblastisch-zentrozytischem (CB-CC) und zentroblastischem Lymphom (CB).