SEP testing in deeply comatose and brain dead patients: the role of nasopharyngeal, scalp and earlobe derivations in recording the P14 potential.
Median nerve somatosensory evoked potentials (SEPs) were tested in 50 patients (20 brain dead, 18 comatose and in 12 progressing from coma to brain death, i.e., 32 cases with brain death and 30 cases with coma were recorded). Derivations were taken from nasopharynx, earlobes, scalp, and neck using cephalic and non-cephalic references. Cortical and subcortical SEP components were evaluated, focussing on the P14 potential. There is evidence that rostral and caudal parts of the P14 generator (lemniscus medialis) are differently affected in brain death, resulting in an abolition of the rostral part, while occasionally leaving intact for some time the caudal part. Non-cephalic referenced scalp records pick up the whole P14 dipole, whereas nasopharyngeal and earlobe derivations pick up different parts of P14, depending on the reference used. Scalp-to-nasopharynx records derive the most rostral part of P14; this "rostral P14" was bilaterally lost in all brain dead patients, but preserved in all deeply comatose patients with diffuse brain-stem injuries. Scalp-to-earlobe records, in contrast, picked up a P14 dipole segment reaching more caudally, resulting in a P14 potential also in brain dead patients. It is concluded that midfrontal scalp-to-nasopharynx derivations give the most valuable contribution to the electrophysiological assessment of brain death versus deep coma.
Wagner
W
W
Neurochirurgische Universitätsklinik, Mainz, F.R.G.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D001926:Brain Death / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000503:physiopathology; D003128:Coma / Q000503:physiopathology*; D004431:Ear, External; D004566:Electrodes; D004569:Electroencephalography / Q000379:methods*; D005073:Evoked Potentials, Somatosensory; D006801:Humans; D008875:Middle Aged; D009305:Nasopharynx; D012535:Scalp