title: [Intravenous mitoxantrone use and simultaneous radiotherapy as a palliative treatment in recurrent head and neck tumors].
abstract: After preceding radiotherapy, chemotherapy and/or surgery the therapeutic options are limited in case of recurrence. In order to enhance the effect of a reduced radiation dose we have combined intravenous mitoxantrone and simultaneous irradiation. From 1988 to 1991 22 patients with recurrent head and neck carcinomas were treated with this combined regimen. 20 patients had already been irradiated with 50 to 70 Gy. The second treatment course was given with 19.8 to 56.0 Gy and simultaneous application of one to three courses of mitoxantrone. Eleven (50%) patients achieved a clinical complete remission. A partial remission was seen in nine patients.
authors.affiliation: Klinik für Strahlentherapie und Radiologische Onkologie, Universität Düsseldorf.
authors.forename: T
authors.initials: T
authors.lastname: Schnabel
authors.forename: N
authors.initials: N
authors.lastname: Zamboglou
authors.forename: G
authors.initials: G
authors.lastname: Schmitt
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy*; D010166:Palliative Care; D011879:Radiotherapy Dosage
chemical_list: D003037:Cobalt Radioisotopes; D008942:Mitoxantrone
vernacular_title: Intravenöse Mitoxantron-Applikation und simultane Strahlentherapie als palliatives Konzept bei rezidivierten Kopf-Hals-Tumoren.