Palliative therapy of an ectopic Cushing's syndrome due to a metastatic carcinoid tumor.
The case of a 39-year-old patient with ectopic Cushing's syndrome due to a metastatic carcinoid tumor is presented. Palliative therapy consisting of 800 mg ketoconazole and 0.3 mg SMS 201-995/die resulted in clinical remission and correction of hypokalemia and hypercortisoluria. Combined therapy was clearly superior to monotherapy with ketoconazole or SMS 201-995, respectively. Side effects were not observed, the tumor masses remained unchanged throughout the observation period of now 19 months.
Kornely
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Medizinische Klinik und Poliklinik, Abteilung für Endokrinologie und Rheumatologie, Heinrich Heine Universität Düsseldorf, FRG.
Schlaghecke
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R
Horster
F A
FA
D000182:ACTH Syndrome, Ectopic / Q000097:blood / Q000628:therapy*; D000328:Adult; D002276:Carcinoid Tumor / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D003480:Cushing Syndrome / Q000097:blood / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007654:Ketoconazole / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008297:Male; D009382:Neoplasms, Unknown Primary / Q000628:therapy*; D015282:Octreotide / Q000008:administration & dosage*; D010166:Palliative Care
D007654:Ketoconazole; D015282:Octreotide; D006854:Hydrocortisone