Detoxification of pertussis toxin by site-directed mutagenesis: a review of connaught strategy to develop a recombinant pertussis vaccine.
Loosmore
S
S
Connaught Centre for Biotechnology Research, Willowdale, Ontario, Canada.
Cockle
S
S
Zealey
G
G
Boux
H
H
Phillips
K
K
Fahim
R
R
Klein
M
M
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D003001:Cloning, Molecular; D004252:DNA Mutational Analysis; D000939:Epitopes; D051379:Mice; D037342:Pertussis Toxin; D010567:Pertussis Vaccine / Q000235:genetics* / Q000276:immunology; D013329:Structure-Activity Relationship; D014614:Vaccines, Synthetic / Q000235:genetics* / Q000276:immunology; D010566:Virulence Factors, Bordetella / Q000235:genetics* / Q000276:immunology / Q000633:toxicity
D000942:Antigens, Bacterial; D000939:Epitopes; D010567:Pertussis Vaccine; D014614:Vaccines, Synthetic; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin