title: Infantile cortical hyperostosis (Caffey disease): ultrastructural and immunohistochemical characterization of the peritrabecular cells.
abstract: The ultrastructure and the immunohistochemical pattern of the cells which are responsible for the bone resorption in the cortical infantile hyperostosis were investigated. The osteoclasts present a great positivity to MB1 antigen and a low positivity to OKM5. Mononuclear cells with primary lysosomes, looking like osteoclast ones are present in high concentration in peritrabecular spaces. These cells show a high positivity to OKM5 antigen and a low positivity to MB1 antigen. The mononuclear granulated cells are positive to tartrate-resistent acid phosphatase. The possible common origin and their co-operation in bone resorption is discussed.
authors.affiliation: Dipartimento di CitoMorfologia, Universitá degli Studi, Cagliari, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Quacci
authors.forename: U E
authors.initials: UE
authors.lastname: Pazzaglia
authors.forename: C
authors.initials: C
authors.lastname: Dell'Orbo
authors.forename: M G
authors.initials: MG
authors.lastname: Ennas
mesh_terms: D015703:Antigens, CD; D001862:Bone Resorption / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D018955:CD36 Antigens; D051925:CD79 Antigens; D006801:Humans; D006958:Hyperostosis, Cortical, Congenital / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008562:Membrane Glycoproteins / Q000378:metabolism; D008854:Microscopy, Electron; D010010:Osteoclasts / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011947:Receptors, Antigen, B-Cell
chemical_list: D015703:Antigens, CD; D018955:CD36 Antigens; D051925:CD79 Antigens; C497881:CD79A protein, human; D008562:Membrane Glycoproteins; D011947:Receptors, Antigen, B-Cell