Effects of Ringer's lactate, Interceed(TC7) and Gore-Tex Surgical Membrane on postsurgical adhesion formation.
OBJECTIVE
To evaluate the effects of Ringer's lactate instillation, Interceed(TC7) (Johnson and Johnson Medical, Inc., New Brunswick NJ), and Gore-Tex Surgical Membrane (W. L. Gore and Associates, Inc., Flagstaff, AZ) in a rat uterine horn model.


METHODS
Rats were in a conventional laboratory setting.


METHODS
Sprague-Dawley white rats, weighing 225 to 250 g.


METHODS
The left uterine horn was subjected to a standardized lesion by serosal denudation and devascularization. The rats were randomly assigned into control group, Interceed(TC7) group, Gore-Tex group, and Ringer's lactate group.


METHODS
Degree of adhesions was evaluated 2 weeks after the initial surgery.


RESULTS
Adhesion score after Ringer's lactate instillation was significantly lower than those of control, Interceed(TC7), and Gore-Tex groups. Gore-Tex was associated with less adhesion formation than control. No difference was found in the adhesion formation between the Interceed(TC7) group and the control group.


CONCLUSIONS
Confirming our previous observations, Ringer's lactate instillation is effective in decreasing adhesion formation. Gore-Tex reduces adhesion formation, but its efficacy is inferior to those of Ringer's lactate. Contrary to previous reports, Interceed(TC7) is ineffective in our animal model.
Pagidas
K
K
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Tulandi
T
T
D000818:Animals; D002483:Cellulose, Oxidized; D005260:Female; D007552:Isotonic Solutions; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D000077325:Ringer's Lactate; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery*
D002483:Cellulose, Oxidized; C060002:INTERCEED; D007552:Isotonic Solutions; D008567:Membranes, Artificial; D000077325:Ringer's Lactate; D011138:Polytetrafluoroethylene