title: The evolutionary history of the sarafotoxin/endothelin/endothelin-like superfamily.
abstract: The evolutionary relationships among 17 protein and nucleic acid sequences from the sarafotoxin/endothelin/endothelin-like superfamily of peptides were studied. The endothelin/endothelin-like gene family has diverged from an ancestral gene that has experienced an exon duplication event followed by two complete gene duplications. The sarafotoxin lineage diverged from the ancestral gene prior to the first gene duplication event. In several lineages, the peptides have independently accumulated identical amino acid replacements in position 2. This finding supports the hypothesis that residue 2 is crucial to biological activity.
authors.affiliation: Department of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel.
authors.forename: G
authors.initials: G
authors.lastname: Landan
authors.forename: A
authors.initials: A
authors.lastname: Bdolah
authors.forename: Z
authors.initials: Z
authors.lastname: Wollberg
authors.forename: E
authors.initials: E
authors.lastname: Kochva
authors.forename: D
authors.initials: D
authors.lastname: Graur
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D004285:Dogs; D016232:Endothelins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D051379:Mice; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine; D014757:Viper Venoms / Q000737:chemistry / Q000235:genetics*
chemical_list: D016232:Endothelins; D014757:Viper Venoms; C057354:sarafotoxins s6