Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma.
The serum level and urinary output of basic and acidic fibroblast growth factors (FGFs) were measured by sandwich enzyme immunoassay (EIA) in patients with renal cell carcinoma. In over fifty percent (16/31) of renal cell carcinoma patients, basic FGF was elevated (greater than 30 pg/ml) in their sera. There is relatively good correlation between serum levels of basic FGF and tumor stage or grade, while urinary daily output of basic FGF did not correlate with increased malignancy. The present results indicate that serum basic FGF level of patients with renal cell carcinoma is a useful diagnostic and prognostic marker for renal cell carcinoma. On the other hand, acidic FGF was not detectable in all sera and urine.
Fujimoto
K
K
Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
Ichimori
Y
Y
Kakizoe
T
T
Okajima
E
E
Sakamoto
H
H
Sugimura
T
T
Terada
M
M
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D015152:Blotting, Northern; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000652:urine; D016220:Fibroblast Growth Factor 1 / Q000097:blood / Q000652:urine; D016222:Fibroblast Growth Factor 2 / Q000097:blood* / Q000652:urine; D006801:Humans; D007124:Immunoenzyme Techniques; D007680:Kidney Neoplasms / Q000097:blood* / Q000652:urine; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000032:analysis; D012334:RNA, Neoplasm / Q000032:analysis
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D016222:Fibroblast Growth Factor 2; D016220:Fibroblast Growth Factor 1