Intralesional injection of bleomycin sulphate into resistant warts in renal transplant recipients versus non-transplant warty patients.
Sixteen adult renal transplant patients and 20 non-transplant patients with warts underwent intralesional therapy with bleomycin sulphate. One unit/ml bleomycin sulphate was injected in 93 warts in renal transplant recipients and 100 warts in non-transplant patients with proven resistance to conventional treatment for at least 6 months. The treatment was compared with a normal saline placebo injected into the paired warts in the same patient. Thirty-four out of 93 warts (37%) in renal transplant recipients vs. 59 out of 100 warts (59%) in non-transplant patients were completely cured after one to three injections. We found bleomycin completely ineffective in 56 warts (60%) in renal transplant recipients, but ineffective in only 17 warts (17%) in non-transplant warty patients. None of the patients treated experienced any side effects except for local pain which was well tolerated, especially by non-transplant patients.
Sobh
M A
MA
Urology & Nephrology Center, Mansoura University, Egypt.
Abd El-Razic
M M
MM
Rizc
R A
RA
Eid
M M
MM
Abd el-Hamid
I A
IA
Ghoneim
M A
MA
D000293:Adolescent; D000328:Adult; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000188:drug therapy*; D014860:Warts / Q000188:drug therapy*
D001761:Bleomycin