[Virus induced acquired immunodeficiency: correlation with T cell mediated destruction of spleen and lymph node architecture].
Mice infected with the non-cytopathic lymphocytic choriomeningitis virus (LCMV) develop a severe acquired immune suppression. This is caused by the elimination of virus infected antigen presenting cells by cytotoxic T cells leading to a severe destruction of the follicular organization of lymphoid organs. The impairment of immune functions may allow the virus to establish persistent infections in initially immunocompetent hosts.
Odermatt
B F
BF
Institut für Pathologie, Universitätsspital, Zürich/Schweiz.
Schalcher
C
C
D000818:Animals; D000911:Antibodies, Monoclonal; D007150:Immunohistochemistry; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008216:Lymphocytic Choriomeningitis / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal
Virus-induzierter erworbener Immundefekt: Korrelation mit T-Zell-vermittelter Zerstörung der Milz- und Lymphknotenarchitektur.