title: Cloning and sequencing of human FSH receptor cDNA.
abstract: We have isolated and sequenced a cDNA encoding the follicle stimulating hormone (FSH) receptor. The deduced amino acid sequence (678 residues) containing seven putative transmembrane segments which displays sequence similarity to G protein-coupled receptors. The receptor consists of 359 residue extracellular domain which contains four N-linked glycosylation sites. While the protein is 89% identical overall with the previously cloned rat FSH receptor, the most highly conserved regions are the putative transmembrane segments (95% similarity).
authors.affiliation: Department of Obstetrics and Gynecology, Gunma University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Minegishi
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Takakura
authors.forename: Y
authors.initials: Y
authors.lastname: Ibuki
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: T ]
authors.initials: T]
authors.lastname: Minegish T [corrected to Minegishi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular / Q000379:methods; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D015723:Gene Library; D006031:Glycosylation; D006801:Humans; D008969:Molecular Sequence Data; D010053:Ovary / Q000502:physiology; D011061:Poly A / Q000235:genetics / Q000302:isolation & purification; D011487:Protein Conformation; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D012333:RNA, Messenger; D051381:Rats; D011962:Receptors, FSH / Q000235:genetics*; D011974:Receptors, LH / Q000235:genetics; D015183:Restriction Mapping; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012333:RNA, Messenger; D011962:Receptors, FSH; D011974:Receptors, LH; D011061:Poly A; D012313:RNA; D004247:DNA