Antigen presentation: structural themes and functional variations.
T cells recognize nonnative processed fragments of antigens presented in association with major histocompatibility complex (MHC) class I or class II molecules. Recently, an accumulating body of evidence has provided a functional linkage between antigen presentation events and the cell biology of MHC molecule assembly and transport. In this review Thomas and Vivian Braciale synthesize these developments into a cohesive model of MHC assembly and antigen presentation pathways.
Braciale
T J
TJ
Dept. of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Braciale
V L
VL
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism / Q000648:ultrastructure; D000941:Antigens / Q000276:immunology* / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D004721:Endoplasmic Reticulum / Q000502:physiology; D000939:Epitopes / Q000276:immunology; D006056:Golgi Apparatus / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D010455:Peptides / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000276:immunology
D000941:Antigens; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010455:Peptides; D011948:Receptors, Antigen, T-Cell