title: Novel chiral H3-receptor agonists.
abstract: Several alkyl-substituted histamine derivatives have been synthesized and investigated for their agonistic potency on three classes of histamine receptors. While all investigated compounds are full agonists at H3-receptors their relative potency vs. histamine is strongly varying and culminates in alpha R, beta S-dimethylhistamine which is a highly potent and selective H3-receptor agonist.
authors.affiliation: Institute of Pharmacy, Freie Universität Berlin, FRG.
authors.forename: R
authors.initials: R
authors.lastname: Lipp
authors.forename: J M
authors.initials: JM
authors.lastname: Arrang
authors.forename: J
authors.initials: J
authors.lastname: Buschmann
authors.forename: M
authors.initials: M
authors.lastname: Garbarg
authors.forename: P
authors.initials: P
authors.lastname: Luger
authors.forename: W
authors.initials: W
authors.lastname: Schunack
authors.forename: J C
authors.initials: JC
authors.lastname: Schwartz
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006632:Histamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects; D008761:Methylhistamines / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D018100:Receptors, Histamine H3; D013237:Stereoisomerism
chemical_list: D008761:Methylhistamines; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; C069368:alpha,beta-dimethylhistamine; D006632:Histamine; D011188:Potassium