[Beta 2-microglobulin in the diagnosis of specific involvement of the kidneys in acute leukemias].
Measurements of the serum and urinary beta 2-microglobulin (beta 2-Mg) concentrations in 138 adult patients with various forms of acute leukemia, which were carried out in various periods of the disease, have revealed that serum beta 2-Mg levels were two times higher in the patients with leukemic involvement of the kidneys (5.54 +/- 3.50 mg/l) than in those without renal involvement (2.77 +/- 1.07 mg/l). Consequently, urinary beta 2-Mg excretion was much higher in the patients with renal involvement than in those with intact kidneys (1.512 +/- 3.222 mg/l vs. 0.388 +/- 1.175 mg/l). Mathematical analysis has shown that the risk of leukemic involvement of the kidneys makes up 93.3 percent in acute leukemia patients with serum beta 2-Mg levels surpassing 6.0 mg/l. This permitted a conclusion on the diagnostic value of beta 2-Mg measurements for the detection of specific involvement of the kidneys in acute leukemia.
Vorob'ev
V G
VG
Trunova
E M
EM
Borovkov
N N
NN
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000473:pathology* / Q000652:urine; D007938:Leukemia / Q000097:blood / Q000473:pathology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D001613:beta 2-Microglobulin / Q000032:analysis* / Q000652:urine
D001613:beta 2-Microglobulin
Beta 2-mikroglobulin v diagnostike spetsificheskogo porazheniia pochek pri ostrykh leĭkozakh.