title: Characteristics of histamine and serotonin release from rat mast cells induced by thymic peptides.
abstract: Thymopoietin peptides release histamine and serotonin from rat mast cells. The release has the characteristics of other basic secretagogues in that it occurs rapidly, does not require extracellular Ca2+ ions, and is inhibited by benzalkonium chloride (BAC). These similarities indicate that chemically different basic compounds have common mechanisms for histamine and serotonin release from rat mast cells.
authors.affiliation: Department of Pharmacology, Medical Faculty, Ljubljana, Yugoslavia.
authors.forename: F
authors.initials: F
authors.lastname: Erjavec
authors.forename: I
authors.initials: I
authors.lastname: Ferjan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001548:Benzalkonium Compounds / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D016305:Thymopentin / Q000494:pharmacology; D013946:Thymopoietins / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*
chemical_list: D001548:Benzalkonium Compounds; D010446:Peptide Fragments; D013946:Thymopoietins; D013949:Thymus Extracts; C031407:thymostimulin; D012701:Serotonin; D016305:Thymopentin; D002118:Calcium