Change of external urethral sphincter function in prostatic patients.
External urethral function was urodynamically examined in 13 patients with benign prostatic hypertrophy (BPH) associated with chronic urinary retention and in 5 volunteers. Prevoiding drop in external urethral sphincter pressure was noted in all the volunteers, whereas it was not found in 6 of the 13 cases of BPH. Bladder neck opening pressure was higher in these 6 cases (p less than 0.05). After administration of phentolamine, prevoiding drop was noted in 5 of these 6 cases, and bladder neck opening pressure decreased so much that there was no significant intergroup difference. The above results mean that the increase in alpha-adrenergic receptors makes the prostate, which has been already hypertrophied, less elastic, inhibiting external urinary sphincter function.
Yasuda
K
K
Department of Urology, School of Medicine, Chiba University, Japan.
Nagashima
K
K
Murayama
N
N
Yamanishi
T
T
Tojo
M
M
Shimazaki
J
J
D000368:Aged; D006801:Humans; D008297:Male; D011312:Pressure; D011467:Prostate / Q000294:innervation; D011470:Prostatic Hyperplasia / Q000150:complications / Q000503:physiopathology*; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D014521:Urethra / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology; D016055:Urinary Retention / Q000209:etiology / Q000503:physiopathology*; D014563:Urodynamics / Q000502:physiology
D011942:Receptors, Adrenergic, alpha