Acupuncture to the skin induces release of substance P and calcitonin gene-related peptide from peripheral terminals of primary sensory neurons in the rat.
We immunohistochemically examined the short term effects of electro-acupuncture (E-acupuncture) to the skin on substance P (SP)- and calcitonin gene-related peptide (CGRP) containing primary sensory neurons in the rat. Immunoreactivity to SP and CGRP in these neurons at the treatment site decreased after 30 min of E-acupuncture. These results suggest that E-acupuncture induces release of SP and CGRP from peripheral terminals of primary sensory neurons.
Kashiba
H
H
Department of Physiology, Kansai College of Acupuncture Medicine, Osaka, Japan.
Ueda
Y
Y
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism* / Q000502:physiology; D015671:Electroacupuncture / Q000592:standards*; D005069:Evaluation Studies as Topic; D005205:Fascia / Q000033:anatomy & histology / Q000098:blood supply / Q000294:innervation; D005260:Female; D007150:Immunohistochemistry; D008297:Male; D008856:Microscopy, Fluorescence; D009132:Muscles / Q000033:anatomy & histology / Q000098:blood supply / Q000294:innervation; D009475:Neurons, Afferent / Q000378:metabolism*; D010784:Photomicrography; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000033:anatomy & histology / Q000098:blood supply* / Q000294:innervation; D013373:Substance P / Q000378:metabolism* / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects*
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide