title: Distribution of (fucogalactosyl-)epitope expressing glycoconjugates in rat brain.
abstract: Glycoconjugates are known to be concentrated in plasma membranes, especially in synaptic junctions, where they subserve various functions in neural connectivity. Here we report the cellular distribution of a new monoclonal antibody recognizing (fucogalactosyl) sequences in carbohydrate structures. The most pronounced immunoreactivity was found in fibrous astrocytes, in many parts of the brain and with lower density in various neuronal elements. This points to the expression of identical carbohydrate sequences on molecules within certain glial and neuronal elements. Previous intracerebral injections of the antibody interfered with long term memory formation. Therefore, functions mediated by corresponding glycoproteins in neurons and glia cells or even neuron-glial interactions, might be relevant for information-processing.
authors.affiliation: Institute of Zoology, Technical University of Darmstadt, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Zuschratter
authors.forename: B
authors.initials: B
authors.lastname: Seidel
authors.forename: K H
authors.initials: KH
authors.lastname: Smalla
authors.forename: U
authors.initials: U
authors.lastname: Karsten
authors.forename: H
authors.initials: H
authors.lastname: Scheich
authors.forename: R
authors.initials: R
authors.lastname: Jork
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001253:Astrocytes / Q000166:cytology*; D001921:Brain / Q000098:blood supply / Q000166:cytology*; D001923:Brain Chemistry; D002196:Capillaries / Q000166:cytology; D002240:Carbohydrate Sequence; D000939:Epitopes / Q000032:analysis*; D006001:Glycoconjugates / Q000032:analysis*; D008297:Male; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009474:Neurons / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D006001:Glycoconjugates