title: Blocking antibodies to inhalant allergens and asthma.
abstract: The mechanisms of specific immunotherapy are not still established. Among the lot of immunological changes, induced by immunotherapy, the increase of specific IgG 1, and then of IgG 4 antibodies, during the first months is well demonstrated. The skin-tests, the histamine-release and the human basophil degranulation are significantly decreased after incubation of allergen with the serum of desensitized patients. This antigen neutralizing capacity (blocking antibodies) disappeared when IgG 4 were suppressed from the serum by the mean of activated columns linked either with allergen, or protein A or antihuman IgG4 antibodies. Conversely, the total amount of serum blocking activity was found using pure IgG 4. However, the role of IgG 4 antibodies remains a subject of controversy. Since a clear correlation has yet to be established with symptom scores.
authors.affiliation: Service de Médecine Interne, Hôpital Rothschild, Paris.
authors.forename: F
authors.initials: F
authors.lastname: Leynadier
authors.forename: P
authors.initials: P
authors.lastname: Lambin
authors.forename: M
authors.initials: M
authors.lastname: Murrieta
authors.forename: J
authors.initials: J
authors.lastname: Dry
mesh_terms: D000485:Allergens / Q000276:immunology* / Q000627:therapeutic use; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D001491:Basophils / Q000378:metabolism; D003888:Desensitization, Immunologic; D006168:Guinea Pigs; D006636:Histamine Release; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology; D007223:Infant; D008222:Lymphokines / Q000502:physiology; D011446:Prospective Studies; D011817:Rabbits; D012882:Skin Tests
chemical_list: D000485:Allergens; D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D008222:Lymphokines