title: Diffusion model in ion channel gating. Extension to agonist-activated ion channels.
abstract: Previously, we described a model which treats ion channel gating as a discrete diffusion problem. In the case of agonist-activated channels at high agonist concentration, the model predicts that the closed lifetime probability density function from single channel recording approximates a power law with an exponent of -3/2 (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988a. Proc. Natl. Acad. Sci. USA. 85: 1503-1507). This prediction is consistent with distributions derived from a number of ligand-gated channels at high agonist concentration (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988b. Biophys. J. 54: 1165-1168.) but does not describe the behavior of ion channels at low activator concentrations. We examine here an extension of this model to include an agonist binding step. This extended model is consistent with the closed time distributions generated from the BC3H-1 nicotinic acetylcholine receptor for agonist concentrations varying over three orders of magnitude.
authors.affiliation: Department of Pharmacology, N.Y.S. College of Veterinary Medicine, Cornell University, Ithaca 14853.
authors.forename: R E
authors.initials: RE
authors.lastname: Oswald
authors.forename: G L
authors.initials: GL
authors.lastname: Millhauser
authors.forename: A A
authors.initials: AA
authors.lastname: Carter
mesh_terms: D000818:Animals; D001932:Brain Neoplasms; D002460:Cell Line; D004058:Diffusion; D015640:Ion Channel Gating; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D011978:Receptors, Nicotinic / Q000502:physiology*
chemical_list: D007473:Ion Channels; D011978:Receptors, Nicotinic