[Evaluation of the effectiveness of infusion solutions based on electron-microscopic studies].
Two combined hemocorrectors have been developed for the treatment of shock terminal phases. The effectiveness of these infusion solutions was evaluated in the study of the liver and myocardium ultrastructure in experimental animals during the development of ischemic shock and its treatment. It was shown that a combination of the known agents (Rheopolyglucin, lactasol, mannitol and sodium succinate) favourably influenced the structure of the microcirculation bed, but did not affect metabolic disorders typical for a "shock cell". Inclusion into the combined hemocorrector of a molecular autocomplex, a derivative of 1,4-naphthoquinone, producing a membrane-protective effect, has significantly promoted the preservation and recovery of intracellular structures of the liver and myocardium cells.
Levin
G S
GS
Shneĭvaĭs
V B
VB
Gubaev
S A
SA
D000818:Animals; D003911:Dextrans / Q000008:administration & dosage; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007773:Lactates / Q000008:administration & dosage; D019344:Lactic Acid; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008353:Mannitol / Q000008:administration & dosage; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D010952:Plasma Substitutes / Q000008:administration & dosage*; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000473:pathology
D003911:Dextrans; D007773:Lactates; D010952:Plasma Substitutes; D019344:Lactic Acid; D008353:Mannitol
Otsenka éffektivnosti infuzionnykh sred po dannym élektronno- mikroskopicheskikh issledovaniĭ.