Hypothyroidism renders protection against lethal ventricular arrhythmias in a conscious canine model of sudden death.
The protective effect of hypothyroidism against lethal ventricular tachyarrhythmias (VT) in the subacute phase of experimental myocardial infarction (MI) was investigated in 10 thyroidectomized dogs using a conscious model of sudden coronary death. Four weeks after surgical ablation of the thyroid, and having established biochemical hypothyroidism, anterior MI was produced by 120 min of occlusion-reperfusion of the left anterior descending coronary artery. In the subacute phase of MI, the inducibility of VT was investigated using programmed ventricular stimulation (PVS), and the effects on spontaneous development of ventricular fibrillation (VF) were studied by production of posterolateral ischemia at a site remote from the area of the previous infarction. Ischemia was produced by the passage of anodal direct current through a silver wire electrode implanted in the left circumflex coronary (LCX) artery. The results were compared to those from a cohort of 20 existing euthyroid controls that had undergone an identical experimental protocol. No differences were found in heart rate and other electrocardiographic parameters such as the PR, QRS, and QT (paced at 2.5 Hz) and the QTc interval between the hypo- and euthyroid groups. During PVS in the subacute phase of anterior MI, the measured threshold voltage and ventricular refractory periods were similar in both groups. The incidence of inducibility of VT was 100% in the euthyroid animals compared to 60% in the hypothyroid dogs, suggesting an antiarrhythmic effect of hypothyroidism. The incidence of sustained vs. nonsustained VT was similar in both groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Venkatesh
N
N
Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0626.
Lynch
J J
JJ
Uprichard
A C
AC
Kitzen
J M
JM
Singh
B N
BN
Lucchesi
B R
BR
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004285:Dogs; D004569:Electroencephalography; D004594:Electrophysiology; D006339:Heart Rate / Q000187:drug effects; D006352:Heart Ventricles / Q000503:physiopathology; D007037:Hypothyroidism / Q000503:physiopathology*; D007545:Isoproterenol / Q000494:pharmacology; D009203:Myocardial Infarction / Q000503:physiopathology; D013610:Tachycardia / Q000503:physiopathology; D013961:Thyroid Gland / Q000502:physiology; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014693:Ventricular Fibrillation / Q000503:physiopathology
D014284:Triiodothyronine; D007545:Isoproterenol; D013974:Thyroxine