title: Cytotoxicity of zinc chloride in mice in vivo.
abstract: Intraperitoneal administration of zinc chloride (ZnCl2) to Swiss albino mice in vivo induced a significant (p less than or equal to 0.05) increase in the frequencies of chromosomal aberrations of the bone-marrow cells at all concentrations used following acute (7.5, 10, 15 mg/kg body weight) and chronic (2.0, 3.0 mg/kg body wt) treatment. The degree of clastogenicity was directly proportional to the concentrations (p less than or equal to 0.05, trend test) and indirectly to the period of treatment (p less than or equal to 0.05, ANOVA test). It induced a dose-dependent, statistically significant increase (Mann-Whitney U statistics, Student's t-test) in sperm-head abnormalities. The data designate ZnCl2 as a potent clastogen and as a toxic chemical at the concentrations used.
authors.affiliation: Centre for Advanced Study in Cell and Chromosome Research, Department of Botany, University of Calcutta, Calcutta, India.
authors.forename: T
authors.initials: T
authors.lastname: Gupta
authors.forename: G
authors.initials: G
authors.lastname: Talukder
authors.forename: A
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002712:Chlorides / Q000633:toxicity*; D002869:Chromosome Aberrations; D004822:Epididymis / Q000187:drug effects; D008297:Male; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D009153:Mutagens / Q000633:toxicity; D013077:Sperm Head / Q000187:drug effects; D013194:Staining and Labeling; D015032:Zinc / Q000633:toxicity*; D017967:Zinc Compounds
chemical_list: D002712:Chlorides; D008934:Mitogens; D009153:Mutagens; D017967:Zinc Compounds; C016837:zinc chloride; D015032:Zinc