In vitro assays for detecting neutralizing and fusion-inhibiting antibodies to SIVMAC251.
Sensitive and reproducible assays for SIV infection and syncytium formation have been developed in which high titers of neutralizing and fusion-inhibiting antibodies can be recorded. These assays will contribute toward our understanding of the role of humoral responses in SIV vaccine strategies.
Langlois
A J
AJ
Duke University Medical Center, Durham, NC 27710.
Weinhold
K J
KJ
Matthews
T J
TJ
Bolognesi
D P
DP
D000914:Antibodies, Viral / Q000032:analysis* / Q000276:immunology; D002460:Cell Line; D015726:Giant Cells; D006801:Humans; D009500:Neutralization Tests; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D015302:Simian Immunodeficiency Virus / Q000201:enzymology / Q000276:immunology*; D014773:Virology / Q000379:methods
D000914:Antibodies, Viral; D012194:RNA-Directed DNA Polymerase