[Effects of C-terminal fragment of substance P-CP 5-11 on the activity of neurons of the dorsal raphe nucleus].
The experiments on Wistar rats showed that microinjection of C-terminal fragment of substance P-CP5-11 (1 microgram) into one of the antinociceptive system structure--dorsal raphe nucleus, caused a prolonged (24 hours of observation) analgetic effect by the hot plate test. Neuronal activity of dorsal raphe nucleus simultaneously enhanced. The CP5-11 antinociceptive activity was higher than the CP1-11 one. The conclusion is that CP1-11 and in particular its C-terminal fragment CP5-11 play a role in activation of antinociceptive system.
Kryzhanovskiĭ
G N
GN
Igon'kina
S I
SI
Trubetskaia
V V
VV
Oeme
P
P
Odariuk
Iu
Iu
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D009474:Neurons / Q000187:drug effects*; D010147:Pain Measurement; D010446:Peptide Fragments / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013373:Substance P / Q000494:pharmacology*
D000700:Analgesics; D010446:Peptide Fragments; D013373:Substance P; C031661:substance P (5-11)
Vliianie C-kontsevogo fragmenta substantsii P-CP 5-11 na aktivnost' neĭronov dorsal'nogo iadra shva.