title: [Treatment with iloprost of critical ischemia of the lower limbs associated with cardiac insufficiency. Study of the interaction with pharmacokinetics of digoxin].
abstract: Twelve patients with critical ischaemia of the lower limbs were treated with iloprost. The purpose of this study was to investigate for a possible iloprost-digoxin interaction and to evaluate the clinical benefit provided by short- or long-term iloprost therapy. The pharmacokinetics of digoxin were studied before and during iloprost treatment. Under iloprost the absorption of digoxin was delayed by about one hour, but the area under the plasma digoxin concentration curve remained unmodified. In 11 of our 12 patients the clinical effect of iloprost was satisfactory both immediately and after 6 months. Pain vanished in 6 patients and diminished in 6 patients. All skin ulcers were healed. In most cases this improvement persisted beyond the study period: 2 patients treated at the beginning of the study and who are still followed up have remained improved after 2 1/2 years. Two patients with pain relapse received iloprost in repeated 10 days' courses with successful results. The treatment was relatively well tolerated (headaches, flushing, abdominal pain). Thus, iloprost can avoid amputation in severe arteritis unsuitable for revascularization and for which there is no effective treatment. Patients under digoxin may continue to take this drug in the same doses during treatment with iloprost.
authors.affiliation: Service de Médecine Interne, Hôpital Saint-Antoine, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Cabane
authors.forename: K
authors.initials: K
authors.lastname: Bouslama
authors.forename: P
authors.initials: P
authors.lastname: Giral
authors.forename: A
authors.initials: A
authors.lastname: Benchouieb
authors.forename: O
authors.initials: O
authors.lastname: Picard
authors.forename: J
authors.initials: J
authors.lastname: Lebas
authors.forename: M J
authors.initials: MJ
authors.lastname: Wattiaux
authors.forename: I
authors.initials: I
authors.lastname: Penin
authors.forename: G
authors.initials: G
authors.lastname: Souvignet
authors.forename: J C
authors.initials: JC
authors.lastname: Imbert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001167:Arteritis / Q000150:complications / Q000188:drug therapy*; D004077:Digoxin / Q000493:pharmacokinetics; D005260:Female; D006333:Heart Failure / Q000150:complications; D006801:Humans; D016285:Iloprost / Q000378:metabolism / Q000627:therapeutic use*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged
chemical_list: D004077:Digoxin; D016285:Iloprost
vernacular_title: Traitement par iloprost des ischémies critiques des membres inférieurs associées à une insuffisance cardiaque. Etude de l'interaction avec la pharmacocinétique de la digoxine.