New proazulene guaianolides from Thapsia villosa.
Four new guaianolides 2-5 possessing the terpenoid skeleton of archangelolide [6] were isolated from a specimen of Thapsia villosa [chromosome number 2n = 66 (= 6x)]. Attempts to hydrolyze the natural products 2-6 yielded azulenes, mainly 7-acetyl-1,4-dimethylazulene [9].
Smitt
U W
UW
Department of Pharmacognosy and Organic Chemistry, Royal Danish School of Pharmacy, Copenhagen.
Cornett
C
C
Andersen
A
A
Christensen
S B
SB
Avato
P
P
D000818:Animals; D006636:Histamine Release / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects; D015394:Molecular Structure; D010944:Plants / Q000032:analysis*; D051381:Rats; D012867:Skin / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification* / Q000494:pharmacology
D013729:Terpenes