[The comparative characteristics of the interferon-inducing capacity of 2 preparations related to aromatic hydrocarbons].
Aromatic hydrocarbons are rightly considered to belong to most active synthetic interferon inducers among low molecular compounds. A comparative evaluation of L-1 (acridanon) and amixin (fluorenon) showed L-1 to have more marked interferon-inducing properties. Both compounds differed not only in the dynamics and levels of interferon synthesis in different organs which suggests the possibility of their employment in different diseases, but also in the efficacy of the modes of application. L-1 induced IF synthesis most actively after subcutaneous inoculation, amixin after oral administration.
Tazulakhova
E B
EB
Kozlovskiĭ
M M
MM
Chizhov
N P
NP
Borisova
M S
MS
Ershov
F I
FI
D000166:Acridines / Q000008:administration & dosage / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D007369:Interferon Inducers / Q000008:administration & dosage / Q000494:pharmacology*; D007372:Interferons / Q000032:analysis; D007739:L Cells; D051379:Mice; D008808:Mice, Inbred CBA; D011083:Polycyclic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D013994:Tilorone / Q000008:administration & dosage / Q000494:pharmacology
D000166:Acridines; D007369:Interferon Inducers; D011083:Polycyclic Compounds; D007372:Interferons; D013994:Tilorone
Sravnitel'naia kharakteristika interferonindutsiruiushcheĭ sposobnosti dvukh prparatov, otnosiashchikhsia k aromaticheskim uglevodorodam.