[Significance of neuronal acetylcholine receptors as differentiation antigens in neuroblastomas and paragangliomas].
Using a panel of monoclonal antibodies to various epitopes of the alpha-, beta- and gamma-subunit of the muscle acetylcholine receptor (AchR), two different immunohistochemical reactivity patterns--corresponding to different neuronal AchRs--were identified in ganglia of the peripheral and central nervous system. The immunoreactivity pattern of neuroblastomas and paragangliomas was identical to the pattern found in the peripheral nervous system and has not been encountered in any other tumor type. Both the intensity of neuronal AchR immunoreactivity and the transcription of the neuronal AchR alpha-gene seem to correlated with a higher degree of neuroblastoma differentiation.
Marx
A
A
Pathologisches Institut, Universität Würzburg.
Geuder
K I
KI
Altmannsberger
M
M
Schömig
E
E
Kirchner
T
T
Müller-Hermelink
H K
HK
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation / Q000032:analysis*; D005724:Ganglia / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D009447:Neuroblastoma / Q000276:immunology / Q000473:pathology*; D009474:Neurons / Q000166:cytology / Q000473:pathology / Q000502:physiology*; D010235:Paraganglioma / Q000276:immunology / Q000473:pathology*; D010641:Phenotype; D011950:Receptors, Cholinergic / Q000032:analysis*
D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D011950:Receptors, Cholinergic
Die Bedeutung neuronaler Acetylcholinrezeptoren als Differenzierungsantigene in Neuroblastomen und Paragangliomen.