MC903, an analogue of 1,25-dihydroxyvitamin D3, increases the synthesis of nerve growth factor.
The effect of MC903, an analogue of 1,25-dihydroxyvitamin D3, on the expression of the nerve growth factor (NGF) gene has been studied in L cells. MC903 induces an increase in both NGF mRNA and protein with a time course similar to that obtained with 1,25-dihydroxyvitamin D3. This finding points to the potential importance of 1,25-dihydroxyvitamin D3 derivatives in the treatment of NGF-sensitive disorders.
Jehan
F
F
INSERM U 298, Centre Hospitalier Régional et Universitaire, Angers, France.
Neveu
I
I
Barbot
N
N
Binderup
L
L
Brachet
P
P
Wion
D
D
D000818:Animals; D015152:Blotting, Northern; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000494:pharmacology; D002478:Cells, Cultured; D015342:DNA Probes; D051379:Mice; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D012313:RNA / Q000032:analysis
D015342:DNA Probes; D009414:Nerve Growth Factors; C055085:calcipotriene; D012313:RNA; D002117:Calcitriol