FK 506 is less cytotoxic than cyclosporine to human and rat hepatocytes in vitro.
Loréal
O
O
Unité de Recherches Hépatologiques, Hôpital Pontchaillou, Rennes, France.
Fautrel
A
A
Meunier
B
B
Guyomard
C
C
Guillouzo
A
A
Launois
B
B
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D016572:Cyclosporine / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009499:Neutral Red / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D016559:Tacrolimus / Q000494:pharmacology*
D009499:Neutral Red; D016572:Cyclosporine; D016559:Tacrolimus