Development of hypertension in WKY rats after transplantation of parathyroid glands from SHR/SP.
We have investigated the role of the parathyroid gland (PTG) in the long-term development of blood pressure (BP) in stroke prone spontaneously hypertensive rats (SHR/SP) and Wistar Kyoto (WKY) rats. After ablation of their own PTGs, SHR/SP animals received PTGs from WKY rats and vice versa. Transplantation resulted in a normal calcium and parathyroid hormone status without signs of hypoparathyroidism. All animals received a high salt diet (8% NaCl) for 4 weeks after transplantation of PTGs. In SHR/SP, which received PTGs from WKY, development of high BP was clearly attenuated when compared to sham-operated SHR/SP rats. WKY rats with PTGs from SHR/SP rats became hypertensive, while WKY sham-operated animals remained normotensive. PTGs from SHR/SP rats are able to induce hypertension in normotensive WKY rats.
Neuser
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D
Department of Pharmacology, BAYER AG, Pharma Research Center, Wuppertal, F.R.G.
Schulte-Brinkmann
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R
Kazda
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S
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002118:Calcium / Q000097:blood / Q000652:urine; D000242:Cyclic AMP / Q000652:urine; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D010280:Parathyroid Glands / Q000637:transplantation*; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D014184:Transplantation, Homologous
D000242:Cyclic AMP; D002118:Calcium