Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli.
1. The responses to mechanical stimulation of myelinated fibers that originate from an acutely cut nerve or a neuroma were studied in the anesthetized monkey. The superficial radial or sural nerve was tightly ligated and cut. Either immediately (acute experiment) or 2-6 wk later (chronic experiment), single-unit recording techniques were used to record the evoked neural activity after vibratory mechanical stimulation (5-100 Hz; 50-800 microns) near the injury site. 2. The 30 myelinated afferents studied in the chronic experiments displayed an entrained response (1 action potential for each stimulus cycle) to vibratory stimuli applied at or near the nerve injury site. For 19 fibers, the minimum amplitude for entrainment was determined as a function of frequency (tuning curve). For 11 others, complete tuning curves were not obtained, although the frequency range over which they were most sensitive could be estimated. The afferents could be classified into three groups on the basis of the frequency range over which they were most sensitive: 1) a low-frequency group that was most sensitive to frequencies less than or equal to 5 Hz (n = 7), 2) a mid-frequency group that was most sensitive to a broad range of frequencies (i.e., 20-75 Hz, n = 13), and 3) a high-frequency group that was most sensitive to frequencies greater than or equal to 100 Hz (n = 10). These three response classes are similar to the three classes of response associated with the different low-threshold mechanoreceptors (i.e., slowly and rapidly adapting and Pacinian-like mechanoreceptors).(ABSTRACT TRUNCATED AT 250 WORDS)
Koschorke
G M
GM
Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21205.
Meyer
R A
RA
Tillman
D B
DB
Campbell
J N
JN
D000818:Animals; D001370:Axonal Transport / Q000502:physiology; D008251:Macaca; D008465:Mechanoreceptors / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D009463:Neuroma / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D010543:Peroneal Nerve / Q000502:physiology; D010812:Physical Stimulation; D011826:Radial Nerve / Q000502:physiology; D013497:Sural Nerve / Q000502:physiology; D013696:Temperature; D014732:Vibration