[Biodegradable gentamicin-depot implants made of beta-tricalcium phosphate ceramics. 3. In vivo studies on drug release, tissue tolerance, and biodegradation].
In vivo drug release properties and biocompatibility of gentamicin-loaded controlled release implants made of beta-tricalcium phosphate ceramics designed for the local antibiotic treatment of bone infections were investigated. Controlled release pellets containing 0.4 and 0.8 mg of gentamicin were implanted into the femoral bone of rats. Drug release was measured from renal excretion over a time period of 3 weeks. The excretion pattern can be described by an initial phase of increased drug release was faster at higher drug loading. Drug release from glyceride-containing controlled release pellets occurs at a significantly slower rate than from drug-loaded pellets without glycerides. Histological studies after implantation of the pure ceramic pellets and the controlled release pellets into the bone tissue of rats and rabbits are showing a high tissue tolerance and the biodegradability of the implants. However, the glyceride-containing pellets are degraded at a slower rate than the pure ceramic pellets.
Thoma
K
K
Institut für Pharmazie und Lebensmittelchemie, Ludwig-Maximilians-Universität, München.
Alex
R
R
Randzio
J
J
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002130:Calcium Phosphates / Q000009:adverse effects / Q000378:metabolism*; D002516:Ceramics; D003692:Delayed-Action Preparations; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013194:Staining and Labeling
D002130:Calcium Phosphates; D003692:Delayed-Action Preparations; D005839:Gentamicins; C485817:beta-tricalcium phosphate; C018392:tricalcium phosphate
Biodegradierbare Gentamicin-Depotimplantate aus Beta-Tricalcium-phosphatkeramik. 3. Mitteilung: In vivo-Untersuchungen zur Wirkstoffabgabe, Gewebeverträglichkeit und Biodegradation.