Hb F-Catalonia or alpha 2G gamma(2)15(A12)Trp----Arg.
Hb F-Catalonia, a G gamma chain variant with a Trp----Arg substitution at position gamma 15(A12), was observed in two Spanish newborn babies from Northeastern Spain. Analyses were performed with different reversed phase high performance liquid chromatographic procedures that allowed the identification of the amino acid replacement in only a minute quantity of the isolated G gamma X chain.
Plaseska
D
D
Department of Cell and Molecular Biology, Medical College of Georgia, Augusta 30912-2100.
Wilson
J B
JB
Kutlar
F
F
Font
L
L
Baiget
M
M
Huisman
T H
TH
D000596:Amino Acids / Q000032:analysis; D005319:Fetal Hemoglobin / Q000737:chemistry*; D006455:Hemoglobins, Abnormal / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D013030:Spain
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; C067965:hemoglobin F Catalonia; D005319:Fetal Hemoglobin