Expression of monocyte chemotactic protein-1 in human melanoma in vivo.
A common feature of human melanoma is infiltration by monocytes at early stages of tumorigenesis. This infiltration may be highly significant since macrophages have the capacity to alter the behavior of tumor cells. The authors previously demonstrated that the predominant monocyte chemoattractant produced by tumor cells in vitro was monocyte chemotactic protein-1 (MCP-1). The authors identify the expression of MCP-1 in pathologic specimens of both primary and metastatic human melanoma but not in normal skin. The finding that MCP-1 is produced by malignant melanoma suggests that specific genes are expressed in tumor cells that can induce the recruitment of monocytes in vivo.
Graves
D T
DT
Department of Oral Biology, Boston University Medical Center, MA 02118.
Barnhill
R
R
Galanopoulos
T
T
Antoniades
H N
HN
D002465:Cell Movement; D018932:Chemokine CCL2; D002630:Chemotactic Factors / Q000032:analysis / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000737:chemistry / Q000235:genetics*; D009000:Monocytes / Q000737:chemistry / Q000473:pathology; D009693:Nucleic Acid Hybridization; D012878:Skin Neoplasms / Q000737:chemistry / Q000235:genetics*
D018932:Chemokine CCL2; D002630:Chemotactic Factors; D004273:DNA, Neoplasm