title: Significance of human T-lymphotropic virus type I indeterminant serological findings among healthy individuals.
abstract: Follow-up studies on 67 blood donors with indeterminant serological findings for human T-lymphotropic virus (HTLV) type I by standard immunoassays showed no evidence of infection by polymerase chain reaction analysis for HTLV-I or HTLV-II nucleic acids or by antibody reactivity to a unique HTLV-I recombinant envelope protein, MTA-4. Among HTLV-I- or -II-infected individuals, a history of blood transfusion, past residence in established HTLV-I endemic areas or some association with intravenous drug use were common. In contrast, 85% of indeterminant cases had none of these risk factors. These observations suggest that healthy individuals with indeterminant serology for HTLV-I should not require additional studies.
authors.affiliation: Department of Pathology, Stanford University Medical Center, Calif.
authors.forename: J J
authors.initials: JJ
authors.lastname: Lipka
authors.forename: K K
authors.initials: KK
authors.lastname: Young
authors.forename: S Y
authors.initials: SY
authors.lastname: Kwok
authors.forename: G R
authors.initials: GR
authors.lastname: Reyes
authors.forename: J J
authors.initials: JJ
authors.lastname: Sninsky
authors.forename: S K
authors.initials: SK
authors.lastname: Foung
mesh_terms: D000328:Adult; D001782:Blood Donors; D015153:Blotting, Western; D000939:Epitopes / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D015481:HTLV-I Antibodies / Q000097:blood; D015482:HTLV-II Antibodies / Q000097:blood; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015531:Radioimmunoprecipitation Assay
chemical_list: D000939:Epitopes; D015481:HTLV-I Antibodies; D015482:HTLV-II Antibodies