title: [Conformational analysis of tachykinins. I. N-terminal fragments of substance P, physalemin, hylambatin, and uperolein].
abstract: Theoretical conformational analysis of N-terminal fragments of the title peptides has been carried out using the potential energy calculations. The number of conformational states for each fragment is very limited, and they are easily interconverted. Since these fragments cannot form alpha-helises, it is unlikely that upon binding of tachikinins to their receptors, their N-terminal fragments could overcome the hydrophobic barrier of the cell membrane's lipid belayer.
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Avanov
mesh_terms: D000595:Amino Acid Sequence; D008051:Lipid Bilayers; D008969:Molecular Sequence Data; D010803:Physalaemin / Q000031:analogs & derivatives / Q000737:chemistry; D011487:Protein Conformation; D013373:Substance P / Q000737:chemistry; D015320:Tachykinins / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D015320:Tachykinins; D010803:Physalaemin; D013373:Substance P; C010367:uperolein; C041501:hylambatin
vernacular_title: Konformatsionnyĭ analiz takhikininov. I. N-kontsevye fragmenty veshchestva P, fizalemina, gilambatina, i uperoleina.