Histo-bacteriological investigation on borderline tuberculoid leprosy.
The multi-sections, which were stained by Fite method, of skin biopsies taken from twelve active BT cases were examined under the guidance of special stains for demonstration of nerve components. All cases were AFB positive. Bacilli were found in infiltrated nerves in 11 cases, of which, in 7 cases, bacilli were detected in nerve fragments within epithelioid cell granuloma. And bacilli were seen in arrector pili muscles in 2 cases. No bacilli were detected in other sites. Since the survival of M. leprae in nerves is one of the reasons causing relapse, this paper suggests that it would be better to treat active BT cases with multibacillary regimen recommended by WHO even though smear-negative.
Wang
T
T
National Institute for Leprosy Research, Tokyo.
Butt
K I
KI
Maeda
Y
Y
Kawatsu
K
K
Izumi
S
S
D006801:Humans; D015441:Leprosy, Tuberculoid / Q000382:microbiology* / Q000473:pathology; D010525:Peripheral Nerves / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D012867:Skin / Q000294:innervation / Q000382:microbiology / Q000473:pathology; D013194:Staining and Labeling / Q000379:methods*