Nonspecific defence mechanism: the role of nitric oxide.
There is a marked contrast between the extraordinary complexity and specificity of the adaptive immune response and the limited number of effector mechanisms that it can direct. Recently, a great deal of interest has focused on the possible role of nitric oxide (NO) in one of these mechanisms. Here F.Y. Liew and Frank Cox examine the evidence supporting a role for NO in parasitic disease and suggest possible mechanism of NO-mediated parasite damage.
Liew
F Y
FY
Dept of Experimental Immunobiology, Wellcome Research Laboratories, Langley Court, Beckenham, UK.
Cox
F E
FE
D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000818:Animals; D016207:Cytokines / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D005609:Free Radicals; D007896:Leishmaniasis / Q000503:physiopathology; D008262:Macrophage Activation; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase; D010100:Oxygen / Q000378:metabolism; D010272:Parasitic Diseases / Q000276:immunology / Q000503:physiopathology*; D014611:Vaccination
D016207:Cytokines; D005609:Free Radicals; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D010100:Oxygen