Vitamin K-dependent carboxylation of poly-L-glutamate.
Poly-L-glutamate preparations of varying chain length were used as substrates for bovine liver vitamin K-dependent carboxylase. The quality of these substrates (as measured by their apparent kinetic constants) was comparable to that of the more commonly used tri- and pentapeptides, but the maximal reaction rate increased at increasing chain length.
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Department of Biochemistry, University of Limburg, Maastricht The Netherlands.
Budé
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Vermeer
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D000818:Animals; D019735:Carbon-Carbon Ligases; D002417:Cattle; D007700:Kinetics; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D011099:Polyglutamic Acid / Q000378:metabolism*; D013379:Substrate Specificity
D011099:Polyglutamic Acid; D008025:Ligases; D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase