[The improvement of the tolerance of the kidney for ischemia with the prostacyclin analog iloprost].
Operative trauma, ischemia, release of catecholamines and thermal stimuli in consequence of harvesting, preservation and transplantation deteriorate the renal capillary circulation. By crossing of tolerance limits arises an irreversible transplant damage. The conditions of our examinations were placed in this field. By pre- and postischemic application of Iloprost was demonstrable an improvement of the ischemic tolerance of the kidney. Correction of renal hemodynamics, antiplatelet action and cytoprotection are the reasons of the protective influence of Iloprost in our opinion.
Forth
H J
HJ
Klinik und Poliklinik für Urologie, Martin-Luther-Universität Halle-Wittenberg.
Rebmann
U
U
Heynemann
H
H
Schabel
J
J
Pauer
H D
HD
Mehlhorn
G
G
Scharf
R
R
Mest
H J
HJ
D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D003404:Creatinine / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects; D016285:Iloprost / Q000494:pharmacology / Q000627:therapeutic use*; D007511:Ischemia / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply*; D016030:Kidney Transplantation; D011817:Rabbits; D013552:Swine
D003404:Creatinine; D016285:Iloprost
Untersuchungen zur Verbesserung der Ischämietoleranz der Niere mit dem Prostazyklinanalogen Iloprost.