[Effect of isoproterenol on the liberation of histamine from rat lung mast cells].
Rat lung mast cells were stimulated with drugs with distinct mechanisms of action, namely concanavalin A, compound 48/80 ionophore A23187, in the presence of the beta adrenergic agonist (-)isoproterenol. Cells show a high response when they are stimulated with FNa-calcium. Isoproterenol does not inhibit histamine release induced by any stimuli, but enhances the response to concanavalin A and compound 48/80. Results point to the lack of beta activity on rat lung mast cells.
Vieytes
M R
MR
Departamento de Fisiología, Facultad de Veterinaria, Lugo, España.
Louzao
M C
MC
de la Cruz
L F
LF
Botana
L M
LM
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D004347:Drug Interactions; D006636:Histamine Release / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008168:Lung / Q000166:cytology*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D012969:Sodium Fluoride / Q000494:pharmacology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D011943:Receptors, Adrenergic, beta; D003208:Concanavalin A; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine; D012969:Sodium Fluoride; D007545:Isoproterenol; D002118:Calcium
Efecto del isoproterenol sobre la liberación de histamina en mastocitos de pulmón de rata.