Application of carboxylic-phosphinic mixed anhydrides in the fragment peptide synthesis of protected analogues of substance P.
Mixed carboxylic-phosphinic anhydrides derived from peptide acids and 1-oxo-1-chlorophospholane have been applied in the synthesis of the protected [Leu11]-SP by the fragment coupling strategy. The yields from fragment couplings were ca. 75%, the products were of high purity while the conditions of formation and coupling of the corresponding mixed phosphinic anhydrides, for optimum yields, have been evaluated.
Poulos
C
C
Department of Chemistry, University of Patras, Greece.
Pasalimaniotou
P
P
Manolopoulou
A
A
Tsegenidis
T
T
D000595:Amino Acid Sequence; D000812:Anhydrides / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D008969:Molecular Sequence Data; D010721:Phosphinic Acids / Q000737:chemistry; D013373:Substance P / Q000737:chemistry*
D000812:Anhydrides; D002264:Carboxylic Acids; D010721:Phosphinic Acids; D013373:Substance P