title: [Combination therapy of cardiovascular risk factors].
abstract: Risk factors for cardiovascular diseases, which are the leading cause of mortality in the industrialized countries, are well investigated; however, the results of intervention studies on the therapy of single risk factors were disappointing in the past. Recently, there has been growing evidence that there might be a closer pathophysiological relation between arterial hypertension, hypercholesterolemia, obesity, impaired glucose tolerance and genetic disposition than previously thought. For the treatment of the individual patient, this concept requires a complete work-up and comprehensive therapy of all risk factors. The therapy of several mildly elevated risk factors may be more beneficial than a too vigorous reduction of the blood pressure alone. At the beginning of every therapeutic regimen, there has to be a nonpharmacological approach. Diet and weight reduction even in mild obesity are more efficient in influencing several risk factors at the same time than pharmacological therapy. Metabolic consequences of drug treatment have to be carefully monitored.
authors.affiliation: Departement für Innere Medizin, Universitätsspital Zürich.
authors.forename: B
authors.initials: B
authors.lastname: Weisser
authors.forename: S
authors.initials: S
authors.lastname: Grüne
authors.forename: T
authors.initials: T
authors.lastname: Mengden
authors.forename: T
authors.initials: T
authors.lastname: Spühler
authors.forename: W
authors.initials: W
authors.lastname: Vetter
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D006801:Humans; D006949:Hyperlipidemias / Q000517:prevention & control; D006973:Hypertension / Q000517:prevention & control; D009765:Obesity / Q000517:prevention & control; D012307:Risk Factors
vernacular_title: Kombinierte Therapie kardiovaskulärer Risikofaktoren.