[Comparative effectiveness of class I anti-arrhythmia drugs and the algorithms of their selection in patients with ventricular arrhythmia].
The efficacy of 7 well-known Class I antiarrhythmic agents were retrospectively and by+crossover compared in 2 groups of patients treated in hospital in different years for ventricular arrhythmias. Class IC agents proved to be the most potent in the two groups of patients. The following algorithm is proposed to choose Class I agents: if quinidine or mexiletine is beneficial in the same patients, the other drugs will be also effective. If disopyramide fails to be beneficial, allapinin , ethacizine , propaphenon will be the most effective. When allapinin produces effects, ethacizine and propaphenon show their highest potency, but when each of them fails, a combination of antiarrhythmic agents should be used.
Abdalla
A
A
Mazur
N A
NA
Nazarenko
V A
VA
D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy*; D004206:Disopyramide / Q000627:therapeutic use; D006329:Heart Conduction System / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008801:Mexiletine / Q000627:therapeutic use; D008875:Middle Aged; D011802:Quinidine / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D008801:Mexiletine; D004206:Disopyramide; D011802:Quinidine
Sravnenie éffektivnosti i algoritmy podbora antiaritmicheskikh preparatov I klassa u bol'nykh s zheludochkovymi narusheniiami ritma serdtsa.