Combined exposure to lead and ethanol on tissue concentration of essential metals and some biochemical indices in rat.
The effect of daily oral administration of ethanol (2.5, 5, or 10% in drinking water for 8 wk), lead (10 mg/kg, po, once daily for 8 wk), or their combination on tissue trace-metal concentration and hematopoietic and hepatic biochemical indices was investigated in male rats. Ethanol (10%) ingestion enhanced the hepatic lipid peroxidation and decreased the calcium and magnesium content of blood and liver. Coexposure to lead and ethanol (5 and 10%) produced a more pronounced elevation of blood zinc protoporphyrin (ZPP) and hepatic lipid peroxidation. Combined lead-ethanol exposure also lowered the concentration of blood and hepatic magnesium and calcium and increased the amount of lead in the blood, liver, and brain compared to a group treated with lead alone. The results suggest that chronic alcohol ingestion results in calcium and magnesium loss. However, coexposure to lead and ethanol could result in more serious depletion of calcium and magnesium, and this could be the cause of suspected synergism between alcohol consumption and lead poisoning.
Flora
S J
SJ
Division of Pharmacology and Toxicology, Defense Research and Development Establishment, Gwalior, India.
Kumar
D
D
Sachan
S R
SR
Das Gupta
S
S
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000437:Alcoholism / Q000150:complications / Q000378:metabolism*; D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D007854:Lead / Q000493:pharmacokinetics; D007855:Lead Poisoning / Q000150:complications / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014131:Trace Elements / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
D006454:Hemoglobins; D014131:Trace Elements; D007854:Lead; D003300:Copper; D000622:Aminolevulinic Acid; D000624:5-Aminolevulinate Synthetase; D000623:Porphobilinogen Synthase; D008274:Magnesium; D015032:Zinc; D002118:Calcium