Substance P receptors in mammalian central nervous system.
1. Multiple distinct affinity states or sites of substance P (SP) receptors exist in freshly-prepared rat brain membranes. 2. Substance P receptors may couple with islet-activating protein (pertussis toxin) sensitive GTP-binding protein(s). 3. Substance P receptors may be regulated Mg2+ and Na+ in an opposite manner. 4. Some important factor(s), in addition to GTP-binding protein, appear to be involved in SP binding activity. 5. An apparent molecular weight of the SP binding site is approximately 46,000 Da.
Segawa
T
T
Department of Pharmacology, Hiroshima University School of Medicine, Japan.
Nakata
Y
Y
D000818:Animals; D001667:Binding, Competitive; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D002793:Cholic Acids; D003432:Cross-Linking Reagents; D003902:Detergents; D019204:GTP-Binding Proteins / Q000378:metabolism; D006150:Guanine Nucleotides / Q000494:pharmacology; D015636:Magnesium Chloride / Q000494:pharmacology; D008297:Male; D008970:Molecular Weight; D037342:Pertussis Toxin; D051381:Rats; D011919:Rats, Inbred Strains; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology; D013373:Substance P / Q000378:metabolism; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
D002793:Cholic Acids; D003432:Cross-Linking Reagents; D003902:Detergents; D006150:Guanine Nucleotides; D018040:Receptors, Neurokinin-1; D017981:Receptors, Neurotransmitter; D010566:Virulence Factors, Bordetella; D015636:Magnesium Chloride; D013373:Substance P; D012965:Sodium Chloride; D037342:Pertussis Toxin; D019204:GTP-Binding Proteins; C028213:3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate