[Metabolites of neurotransmitters in the cerebrospinal fluid in children].
Metabolites of neurotransmitters, homovanillic acid (HVA) and 5-hydroxyindolacetic acid (5-HIAA) were assessed in the cerebrospinal fluid of 149 children of different age from neonatal age to 13 years by the method of high pressure liquid chromatography with electrochemical detection. The mean concentration of the two metabolites in cerebrospinal fluid correlated indirectly with the childrens age--the highest mean concentrations of HVA and 5-HIAA were found in the group of neonates, lower values in infants and the lowest ones in the group of toddlers and older children. In the group of toddlers and older children with severe mental disorders and repeated tonic-clonic or myoclonic seizures a lower mean 5-HIAA was found in the cerebrospinal fluid than in children of equal age, similarly mentally affected but without seizures in the case-history.
Zeman
J
J
IV. dĕtská klinika 1. lékarské fakulty UK v Praze.
Böswart
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000134:cerebrospinal fluid; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid
D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid
Metabolity neurotransmiterů v mozkomísním moku u dĕtí.