[Antikeratin antibodies in rheumatoid arthritis].
On the basis of the literature and the author's own investigations the present knowledge about antikeratin antibodies (AKA) in rheumatoid arthritis (RA) is summarized. The specificity of AKA for RA is described between 90% and 100%, but the sensitivity is reported as varying from 36% to 80%. In conclusion, AKA have great diagnostic value in RA and, high titre AKA, were found to be pathognomonic for RA. Further studies are necessary to confirm if AKA are also of prognostic and pathogenetic value in RA.
Larsen
H L
HL
Odense Sygehus, blodbank og klinisk immunologisk afdeling.
D000906:Antibodies / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007633:Keratins / Q000276:immunology*; D011379:Prognosis
D000906:Antibodies; D007633:Keratins
Antikeratin-antistoffer ved reumatoid arthritis.