MHC-restriction of antibody responses to an 86 kilodalton antigen of Schistosoma mansoni.
The previously observed MHC-restriction of the antibody response to an 86kDa S. mansoni antigen has been investigated in more detail. The I-A locus of the H-2 complex has been implicated as conferring responder or non-responder status on mice expressing the k and b alleles respectively. Inheritance of responsiveness was dominant over non-responsiveness. An additional level of complexity was observed in the p86 antibody responder status of individuals within a responding inbred strain. This could not be accounted for directly by the level of patent infection, but showed an inverse correlation with the level of egg output in H-2k mice. Differential antibody responsiveness to other antigens, between individuals of the same strain, occurred independently of the differential responsiveness to p86.
Schweitzer
A N
AN
Department of Pathology, University of Cambridge.
Taylor
D W
DW
D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis* / Q000235:genetics; D000947:Antigens, Helminth / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D005243:Feces / Q000469:parasitology; D006183:H-2 Antigens / Q000235:genetics; D006239:Haplotypes; D008285:Major Histocompatibility Complex / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D010270:Parasite Egg Count; D011233:Precipitin Tests; D012313:RNA / Q000235:genetics; D012550:Schistosoma mansoni / Q000254:growth & development / Q000276:immunology*
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D006183:H-2 Antigens; D012313:RNA