Longitudinal study of the cellular response to Pf155/RESA and circumsporozoite protein in Madagascar.
In a community follow-up conducted in the Central Highlands of Madagascar, the cellular responses to synthetic peptides from the immunodominant regions of Pf155/RESA and the repeat region of the circumsporozoite protein were studied. Seasonal variations of the T cell response were measured at the individual level; the relationship between this response and the presence of parasites in blood was assessed; the question of the possible protective value of the lymphocyte proliferation in presence of a specific antigen was addressed.
Chougnet
C
C
INSERM Unité 13, Institut de Médecine et d'Epidémiologie Africaines, Hôpital Claude Bernard, Paris, France.
Deloron
P
P
Lepers
J P
JP
Rason
M D
MD
Savel
J
J
Coulanges
P
P
D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D002648:Child; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008137:Longitudinal Studies; D008270:Madagascar; D008288:Malaria / Q000097:blood / Q000276:immunology / Q000469:parasitology; D008875:Middle Aged; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D012621:Seasons
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D000939:Epitopes; D010446:Peptide Fragments; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan; C050256:ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum