[Recombinant human erythropoietin stimulates synthesis of fetal hemoglobin in patients with renal anemia treated by repeated hemodialysis].
Effect of intravenously administered recombinant human erythropoietin (rHu EPO) on haemoglobin (Hb) level, haematocrit (Ht), reticulocyte count and foetal haemoglobin (HbF) concentration was assessed in 10 patients with anaemia, treated by repeated haemodialysis due to end-stage kidney. As compared to the initial values, erythropoietin treatment brought about a significant increase in all the parameters examined. During the subsequent therapy with lower, supporting doses of erythropoietin, the elevated HbF values fell back to normal, whereas the higher level of total Hb and Ht were maintained.
Hanicki
Z
Z
Kliniki Nefrologii AM w Krakowie.
Sułowicz
W
W
Stepniewski
M
M
Kuźniewski
M
M
Kraśniak
A
A
Kopeć
J
J
Cieszkowska
U
U
Solarska
K
K
D000328:Adult; D000740:Anemia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D005319:Fetal Hemoglobin / Q000096:biosynthesis*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D006435:Renal Dialysis
D011994:Recombinant Proteins; D004921:Erythropoietin; D005319:Fetal Hemoglobin
Rekombinant ludzkiej erytropoetyny pobudza synteze hemoglobiny płodowej u chorych z niedokrwistościa nerkowo-pochodna leczonych powtarzanymi hemodializami.