'Partial D' women with anti-D alloimmunization in pregnancy.
We report five women with Rh 'partial D' who were found to have anti-D during pregnancy. Two patients were category IVa, their red cells typing as Go(a+); one was category VI; and two had a 'partial Du' which could not be categorized. The maternal anti-D concentration increased during four of the eight pregnancies studied, but none reached significant levels. Three of six D-positive cord blood samples had a positive direct antiglobulin test (DAGT). Although one baby became jaundiced, no treatment was required. The policy in the Oxford Region for the management of patients with a weak expression of D is outlined.
Mayne
K M
KM
Regional Blood Transfusion Centre, John Radcliffe Hospital, Oxford.
Allen
D L
DL
Bowell
P J
PJ
D004739:England / Q000453:epidemiology; D000939:Epitopes / Q000276:immunology; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D011247:Pregnancy / Q000276:immunology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012203:Rh Isoimmunization / Q000453:epidemiology; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D000939:Epitopes; D007518:Isoantibodies; C033242:RH-antibodies; D012204:Rh-Hr Blood-Group System; C026410:Rho(D) antigen