title: Coordinate inactivation of class III genes during the Gastrula-Neurula Transition in Xenopus.
abstract: We have identified a period during early Xenopus development when several different genes transcribed by RNA polymerase III (class III genes) are coordinately inactivated. During the late gastrula stage a major reduction in the number of active transcription complexes gives rise to a pattern of class III gene activity typical of adult somatic cells. This event is referred to as the Gastrula-Neurula Transition and involves the inactivation of genes encoding oocyte-type tRNAs and 5S RNA, along with several heterogeneous RNAs expressed during the blastula and gastrula stages of embryogenesis.
authors.affiliation: Department of Genetics, North Carolina State University, Raleigh 27695-7614.
authors.forename: M T
authors.initials: MT
authors.lastname: Andrews
authors.forename: S
authors.initials: S
authors.lastname: Loo
authors.forename: L R
authors.initials: LR
authors.lastname: Wilson
mesh_terms: D000818:Animals; D005775:Gastrula / Q000378:metabolism*; D005786:Gene Expression Regulation; D009420:Nervous System / Q000196:embryology*; D009693:Nucleic Acid Hybridization; D012313:RNA / Q000378:metabolism; D012320:RNA Polymerase III / Q000096:biosynthesis / Q000235:genetics*; D014158:Transcription, Genetic; D014981:Xenopus / Q000196:embryology*
chemical_list: D012313:RNA; D012320:RNA Polymerase III