title: Evaluation of RNA rich fraction of Litmosoides carinii in induction of protection in infected rats.
abstract: The RNA rich fraction of adult L. carinii worms was evaluated in evoking a protective response in infected rats. The RNA immunization was seen to be effective in limiting the microfilaraemia in peripheral blood as well as the adult worm burden. The antibodies to both RNA antigen and adult worm antigen were high in this group of animals at the peak of infection. The RNA immunization was seen to evoke hyperresponsiveness in lymphocytes to mitogens like adult worm antigen, PHA and Con A.
authors.affiliation: Department of Parasitology, Postgraduate Institute of Medical Education & Research, Chandigarh.
authors.forename: H
authors.initials: H
authors.lastname: Vohra
authors.forename: N
authors.initials: N
authors.lastname: Malla
authors.forename: N K
authors.initials: NK
authors.lastname: Ganguly
authors.forename: R C
authors.initials: RC
authors.lastname: Mahajan
mesh_terms: D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis; D000947:Antigens, Helminth / Q000276:immunology*; D005368:Filariasis / Q000517:prevention & control*; D005370:Filarioidea / Q000235:genetics / Q000276:immunology*; D007111:Immunity, Cellular; D007114:Immunization; D008842:Microfilariae / Q000276:immunology; D012313:RNA / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D012313:RNA