[Mechanisms of the anticoagulation activity of new semi-synthetic heparinoids].
Compounds representing chemically modified derivatives of natural polysaccharides and possessing heparin-like properties have been obtained basing on new methods of sulphatization++ of hydroxyl-containing polymers. The study of the anticoagulation activity of mannan, starch, dextran sulfates permits a suggestion that these compounds realize their anticoagulant potential not through antithrombin-III. A relationship has been established between the properties of semi-synthetic heparinoids and sulfur percentage, molecular mass and the type of polymeric matrix. The investigations conducted have made possible the development of effective thrombosis-preventing drugs and further thorough study of their effects.
Azarova
L A
LA
Siatkovskiĭ
V A
VA
Kaputskiĭ
F N
FN
Torgashov
V I
VI
D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D016264:Dextran Sulfate / Q000494:pharmacology*; D004341:Drug Evaluation; D006496:Heparinoids / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008351:Mannans / Q000494:pharmacology*; D008970:Molecular Weight; D013213:Starch / Q000494:pharmacology*; D014586:USSR
D000925:Anticoagulants; D006496:Heparinoids; D008351:Mannans; D013213:Starch; D016264:Dextran Sulfate
Mekhanizmy protivosvertyvaiushcheĭ aktivnosti novykh polusinteti- cheskikh geparinoidov.