title: Sertraline, a serotonin-uptake inhibitor, reduces food intake and body weight in lean rats and genetically obese mice.
abstract: Sertraline was found to inhibit weight gain and decrease food intake without affecting locomotion in rats and genetically obese (ob/ob) mice. Doses of 10, 17.8, and 32 mg/kg, administered intraperitoneally, (bid) significantly reduced the time rats spent in contact with their feeders and body weight in a dose-related manner. During a 5-d bid treatment regimen, vehicle-treated rats gained 37 +/- 3 g (mean +/- SEM), whereas animals treated with 32 mg sertraline/kg lost 34 +/- 4 g. The effects of sertraline on feeding and body weight in rats appeared to be specific because locomotor activity was not altered. In ob/ob mice, sertraline (44 mg/kg, ip, bid) lowered body weight relative to vehicle-treated controls for the duration of a 12-d study. There was no evidence for tolerance to the hypophagic and weight-loss effects of sertraline during either of the chronic dosing studies. These results suggest a potential role for sertraline in the treatment of human obesity.
authors.affiliation: Department of Neuroscience, Pfizer Central Research, Groton, CT 06340.
authors.forename: J A
authors.initials: JA
authors.lastname: Nielsen
authors.forename: D S
authors.initials: DS
authors.lastname: Chapin
authors.forename: J L
authors.initials: JL
authors.lastname: Johnson
authors.forename: L K
authors.initials: LK
authors.lastname: Torgersen
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009043:Motor Activity / Q000187:drug effects; D009765:Obesity / Q000188:drug therapy*; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D020280:Sertraline; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D001067:Appetite Depressants; D012702:Serotonin Antagonists; D015057:1-Naphthylamine; D020280:Sertraline