Mechanism of modulation of GABA-activated current by internal calcium in rat central neurons.
GABA-activated currents in Purkinje cells isolated from rat cerebellum were investigated. Increase of intracellular Ca2+ in the physiological range of concentrations caused a decrease in GABA-activated chloride currents. This effect resulted from a decrease of both the maximal values of GABA-activated currents and possibly from the affinity of GABAA receptors. Therefore, the mechanism of Ca2+ effect on GABAA receptors in central rat neurons differs from that in bullfrog sensory neurons.
Marchenko
S M
SM
A.A. Bogomoletz Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002531:Cerebellum / Q000166:cytology; D002713:Chlorine / Q000378:metabolism; D066298:In Vitro Techniques; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D007473:Ion Channels; D002713:Chlorine; D005680:gamma-Aminobutyric Acid; D002118:Calcium