Developmental and tissue-specific expression of rat T-kininogen.
The ontogeny of T-Kininogen expression in the rat liver was examined. Levels approximately 6 fold higher than seen in the adult liver are present during the perinatal period. Elevated levels are also seen in the maternal liver, beginning 5 days prior to parturition. The timing of induction in the fetal and maternal liver is distinct, suggesting independent regulation. While T-Kininogen mRNA is mainly synthesized in the liver, low but significant expression is seen in other tissues, including lung and kidney.
Mann
E A
EA
Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, OH 45267-0524.
Lingrel
J B
JB
D000375:Aging; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D005260:Female; D007704:Kininogens / Q000235:genetics*; D008099:Liver / Q000196:embryology / Q000254:growth & development; D008297:Male; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D009928:Organ Specificity; D011247:Pregnancy; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D011919:Rats, Inbred Strains
D007704:Kininogens; D015345:Oligonucleotide Probes; D012313:RNA