Disappearance of factor VIII antibodies upon frequent administration of factor VIII.
20 haemophilia patients known to have antibodies against F VIII for at least more than three years were treated on a regular base with 25 U/kg b.w. F VIII every other day. All 5 patients with previous maximal anti F VIII antibody levels between 5 and 60 BU/ml showed a decrease of antibody level and normal F VIII recovery within 1-2 months. From 12 patients with previous antibody levels above 60 BU/ml, 8 showed a disappearance of antibodies within 2-26 months. In 3 patients in whom no previous highest inhibitor level was known, one was treated successfully. Another group of 6 young patients in whom an inhibitor against F VIII had just (less than 3 months) developed, was treated with F VIII as soon as an inhibitor was detected. The dose infused was 25 U/kg b.w. F VIII twice weekly. In 5 patients this regimen was successful within 1-7 months. In the 6th patient the dosage was increased to every other day. One year after the beginning of therapy no inhibitor was detectable. So our results show that regular administration of F VIII in intermediate or low dose can lead to rapid disappearance of anti F VIII antibodies especially in patients with moderate inhibitor levels.
Mauser-Bunschoten
E P
EP
Van Creveld Kliniek, Medisch Centrum Berg en Bosch, Bilthoven, The Netherlands.
Roosendaal
G
G
Bruin
M
M
van Dijken
P J
PJ
D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D005169:Factor VIII / Q000276:immunology / Q000627:therapeutic use*; D006467:Hemophilia A / Q000097:blood / Q000276:immunology* / Q000628:therapy; D006801:Humans
D001323:Autoantibodies; D015415:Biomarkers; D005169:Factor VIII