A study of aqueous humor formation in patients with cystic fibrosis.
The circadian pattern of aqueous formation and the effect of timolol on aqueous flow was studied in 12 patients with cystic fibrosis. Cystic fibrosis is a disease characterized by a defect in a chloride channel-associated regulatory protein found in epithelial cells. Improper regulation of these chloride channels, causes abnormal composition of exocrine secretions, including respiratory tract, gastrointestinal tract, exocrine pancreas, and sweat glands. Ocular findings previously reported include abnormal endothelial cell permeability, decreased tear secretion, and abnormal tear composition. In this study, aqueous humor flow was measured by fluorophotometry. No statistically significant difference was found when flow rates measured during the morning, during the afternoon, at night, and after topical timolol treatment were compared to normal values. The conclusion is that the beta adrenergically regulated chloride selective channels defective in patients in cystic fibrosis do not play a major role in the formation of aqueous humor or they are not regulated by the cystic fibrosis transmembrane conductance regulator (CFTR).
McCannel
C A
CA
Mayo Clinic, Rochester, Minnesota 55905.
Scanlon
P D
PD
Thibodeau
S
S
Brubaker
R F
RF
D000287:Administration, Topical; D000328:Adult; D001082:Aqueous Humor / Q000187:drug effects / Q000378:metabolism*; D002940:Circadian Rhythm; D003550:Cystic Fibrosis / Q000378:metabolism*; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D013999:Timolol / Q000008:administration & dosage
D013999:Timolol