Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.
Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.
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Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093-0648.
Gerrero
R
R
Simmons
D M
DM
Park
R E
RE
Lin
C J
CJ
Swanson
L W
LW
Rosenfeld
M G
MG
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000235:genetics*; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007031:Hypothalamus; D008969:Molecular Sequence Data; D008970:Molecular Weight; D018993:Myelin P0 Protein; D009185:Myelin Proteins / Q000235:genetics*; D050816:Octamer Transcription Factor-6; D009841:Oligonucleotides / Q000737:chemistry; D011401:Promoter Regions, Genetic; D051381:Rats; D014157:Transcription Factors / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D004268:DNA-Binding Proteins; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D009841:Oligonucleotides; C494179:Pou3f1 protein, rat; D014157:Transcription Factors; D050816:Octamer Transcription Factor-6