T cell inducing determinants contain a hierarchy of residues contacting the T cell receptor.
T cells through their antigen specific T cell receptor recognize a bi-molecular ligand composed of an antigenic peptide bound to a MHC molecule. Several T cell inducing determinants have been extensively characterized by single amino acid substitutions. In this review, we have summarized our characterization of four immunodominant determinants. Each of these determinants possessed a single amino acid residue which was absolutely critical for the recognition by T cells. From these data we propose a hypothesis that there is a hierarchy in the T cell contact residues of a determinant, composed of a single primary residue, and a few secondary residues.
Evavold
B D
BD
Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110.
Williams
S G
SG
Chen
J S
JS
Allen
P M
PM
D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000737:chemistry / Q000378:metabolism*; D006454:Hemoglobins / Q000737:chemistry / Q000276:immunology; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008969:Molecular Sequence Data; D009113:Muramidase / Q000737:chemistry / Q000276:immunology; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D012260:Ribonucleases / Q000737:chemistry / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes; D006454:Hemoglobins; D011948:Receptors, Antigen, T-Cell; D012260:Ribonucleases; D009113:Muramidase