title: [The structural changes in the lungs and the phospholipids of the pulmonary surfactant in experimental bleomycin-induced pneumosclerosis in rats].
abstract: Light microscopy was used to study rat lungs. Some morphological and biochemical characteristics after single bleomycin intratracheal administration in a dose of 10 mg/kg were studied. Some metabolic changes in the alveolar epithelium and vascular endothelium were estimated quantitatively. The peculiar picture of acute toxic alveolitis in the early stage of the injury and the features of fibrotic alveolitis by the 30-60th day were observed. The LDH and succinate dehydrogenase activities in the alveolar epithelium increased by the 3-7th day and returned to normal by the 30th day. At the same time the PL content increased 2-fold by the 30-60th day. The lysolecithin, sphingomyelin and phosphatidylserine concentration increased on the 3-7th day and returned to normal level on the 14th day. The phosphatidylglicerol content decreased significantly by the 60th day.
authors.forename: L V
authors.initials: LV
authors.lastname: Loshakova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Kirillov
authors.forename: E S
authors.initials: ES
authors.lastname: Lebedeva
authors.forename: A E
authors.initials: AE
authors.lastname: Shul'ga
authors.forename: L A
authors.initials: LA
authors.lastname: Zlotnikova
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Alekseevskikh
authors.forename: L N
authors.initials: LN
authors.lastname: Danilov
authors.forename: O A
authors.initials: OA
authors.lastname: Rozenberg
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000633:toxicity*; D002855:Chromatography, Thin Layer; D008168:Lung / Q000473:pathology*; D008297:Male; D010743:Phospholipids / Q000032:analysis*; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D011663:Pulmonary Surfactants / Q000032:analysis*; D051381:Rats; D012598:Sclerosis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
chemical_list: D010743:Phospholipids; D011663:Pulmonary Surfactants; D001761:Bleomycin
vernacular_title: Strukturnye izmeneniia legkikh i fosfolipidov legochnogo surfaktanta pri éksperimental'nom bleomitsinovom pnevmoskleroze u krys.