title: Novel inward rectifier blocked by Cd2+ in crayfish muscle.
abstract: The characteristics of a voltage- and time-dependent inward rectifying current were examined with voltage clamp techniques in crayfish muscle. The inward current, carried by K+, was activated by hyperpolarization. Although this inward current increased with the extracellular K+ concentration [( K+]o), the voltage-dependence of the underlying conductance was independent of [K+]o. The current was unaffected by Cs+ and Ba2+, but was blocked by low concentrations of Cd2+. Therefore, this inward rectifier is different than previously described ones.
authors.affiliation: Neurofisiología, Instituto Cajal, CSIC, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Araque
authors.forename: W
authors.initials: W
authors.lastname: Buño
mesh_terms: D000818:Animals; D003400:Astacoidea / Q000502:physiology*; D002104:Cadmium / Q000494:pharmacology*; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D007473:Ion Channels / Q000187:drug effects*; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000187:drug effects*
chemical_list: D007473:Ion Channels; D002104:Cadmium