Synthesis of O-phosphotyrosine-containing peptides.
As a consequence of developments in peptide synthesis, it is now well established that Tyr(P)-containing peptides can be prepared in high yield by the use of Boc-Tyr(PO3Me2)-OH in Boc solution or solid-phase peptide synthesis or Fmoc-Tyr(PO3Me2)-OH in Fmoc/solid-phase peptide synthesis. It is considered that with further developments in solid-phase synthesis techniques and the use of alternative phosphate-protecting groups, the synthesis of large and complex Tyr(P)-containing peptides will be routine.
Perich
J W
JW
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis*; D010748:Phosphopeptides / Q000138:chemical synthesis*; D010766:Phosphorylation; D019000:Phosphotyrosine; D014443:Tyrosine / Q000031:analogs & derivatives*
D007202:Indicators and Reagents; D010455:Peptides; D010748:Phosphopeptides; D019000:Phosphotyrosine; D014443:Tyrosine