Nicotine enhances angina pectoris-like chest pain and atrioventricular blockade provoked by intravenous bolus of adenosine in healthy volunteers.
An attempt was made to study possible interaction between neuromodulation by adenosine and nicotine stimulatory effects. Dose-effect curves were made double blind in 7 nonsmoking, nonsnuffing healthy volunteers (25-49 years) before and during exposition to nicotine roughly corresponding to the nicotine of one cigarette, 2 mg ingested from a chewing gum (800 chews during 20 min). Chest pain was estimated by the Borg CR-10 scale. ECG was followed, and respiration was recorded continuously by spirometry. Maximal tolerable dose of adenosine was 12.7 +/- 3.0 mg. Chest pain increased dose dependently to 5.7 +/- 1.7 units. Nicotine increased the pain response by 20 +/- 15%, (p less than 0.02). The total time with atrioventricular (AV) block provoked by adenosine increased with nicotine (7 +/- 12%, p less than 0.03) while increased ventilation provoked by adenosine was unaffected by nicotine. In conclusion, interaction between adenosine and nicotine was demonstrated. Nicotine enhanced both stimulatory (chest pain) and inhibitory actions (AV-block) of adenosine.
Sylvén
C
C
Department of Internal Medicine, Karolinska Institute, Huddinge University Hospital, Sweden.
Beermann
B
B
Kaijser
L
L
Jonzon
B
B
D000241:Adenosine / Q000494:pharmacology*; D000328:Adult; D000787:Angina Pectoris / Q000150:complications*; D004357:Drug Synergism; D004562:Electrocardiography; D005260:Female; D006327:Heart Block; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced*
D009538:Nicotine; D000241:Adenosine