Bacterial endotoxin: molecular relationships between structure and activity.
The significance of endotoxins in bacterial infection and their role as bacterial surface antigens (O antigens) have stimulated investigations into their chemical nature and the mechanisms of their biologic action during the last few decades. This article summarizes some of the recent results and emphasizes structure-activity relationships.
Rietschel
E T
ET
Forschungsinstitut Borstel, Institut für Experimentelle Biologie und Medizin, Germany.
Seydel
U
U
Zähringer
U
U
Schade
U F
UF
Brade
L
L
Loppnow
H
H
Feist
W
W
Wang
M H
MH
Ulmer
A J
AJ
Flad
H D
HD
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D002240:Carbohydrate Sequence; D004731:Endotoxins / Q000737:chemistry* / Q000276:immunology; D000939:Epitopes; D006090:Gram-Negative Bacteria / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D007107:Immune System; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology; D008969:Molecular Sequence Data; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000907:Antibodies, Bacterial; D004731:Endotoxins; D000939:Epitopes; D008070:Lipopolysaccharides