title: Ionic channels: modulation by G proteins and by phosphorylation.
abstract: The gating of ion channels may be modulated by G proteins or by phosphorylation. Direct coupling between G proteins and ion channels has been shown in excised patches of membrane. Steps must now be taken to study the protein domains of G proteins and ion channels involved in the mutual interaction. The concept of channel modulation by protein kinases has recently been extended to include additional types of ion channel.
authors.affiliation: Department of Pharmacology, University of Berne, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Reuter
authors.forename: E
authors.initials: E
authors.lastname: Sigel
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D010766:Phosphorylation
chemical_list: D007473:Ion Channels; D019204:GTP-Binding Proteins