title: [A poorly differentiated apudoma of the gallbladder].
abstract: Apudoma was found in the gall bladder removed in a 76-year-old woman because of the chronic calculous cholecystitis exacerbation. Carcinoid syndrome was absent clinically. Histologically, the tumour was a poorly differentiated carcinoid with areas of small cell and polymorphic carcinoma. Argyrophilic Pasquale reaction in the tumour cells was negative, electron microscopically small neurosecretory granules were found. Numerous ACTH-reactive cells and single serotonin-reactive cells were revealed in the tumour parenchyma by means of immunohistochemical PAP-method using antibodies against ACTH, serotonin, calcitonin, somatostatin, insulin, glucagon, P-substance. Focal hyperplasia and intestinal metaplasia of epithelium with the increase of the number of argyrophilic, ACTH-reactive cells were observed outside the tumour.
authors.forename: O A
authors.initials: OA
authors.lastname: Smirnov
authors.forename: B S
authors.initials: BS
authors.lastname: Serezhin
authors.forename: I I
authors.initials: II
authors.lastname: Lomakina
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000378:metabolism / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000368:Aged; D001079:Apudoma / Q000378:metabolism / Q000473:pathology*; D002764:Cholecystitis / Q000473:pathology; D002769:Cholelithiasis / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D005704:Gallbladder / Q000378:metabolism / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000378:metabolism / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D013194:Staining and Labeling / Q000379:methods
chemical_list: D000324:Adrenocorticotropic Hormone
vernacular_title: Nizkodifferntsirovannaia apudoma zhelchnogo puzyria.