[Sr(a), a "private" thrombocyte alloantigen as a cause of neonatal alloimmune thrombocytopenia].
Neonatal alloimmune thrombocytopenia (NAIT) is caused by maternal immunization against fetal platelet antigens. In the serum of a mother who gave birth to a child with the typical clinical picture of NAIT we found an antibody directed against the new platelet antigen Sra. Anti-Sra was found to react in the immunofluorescence test and in a glycoprotein (GP) specific immunoassay (MAIPA) using a monoclonal antibody against GP IIb/IIIa for antigen immobilization with the child's and father's platelets. Radioimmunoprecipitation and immunoblot allowed to assign the Sra-antigen to GP IIIa. The phenotype frequency was estimated less than 1%, characterising the Sra-antigen as the first 'private' alloantigen on platelets.
Kroll
H
H
Institut für Klinische Immunologie und Transfusionsmedizin, Justus-Liebig-Universität Giessen.
Kiefel
V
V
Santoso
S
S
Mueller-Eckhardt
C
C
D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D005455:Fluorescent Antibody Technique; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis* / Q000235:genetics; D007519:Isoantigens / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D011247:Pregnancy; D013921:Thrombocytopenia / Q000097:blood* / Q000175:diagnosis
D007518:Isoantibodies; D007519:Isoantigens
Sra, ein "privates" Thrombozyten-Alloantigen als Ursache einer neonatalen Alloimmunthrombozytopenie.