title: Stimulation of carbohydrate metabolising enzymes by synthetic hypertrehalosemic peptides in thoracic musculature of the American cockroach, Periplaneta americana.
abstract: The ability of the synthetic hypertrehalosemic peptides, HT-I and HT-II, to influence the activities of glycogen phosphorylase, trehalase and hexokinase via elevation of Ca++ and cAMP levels was examined in thoracic musculature of the American cockroach, Periplaneta americana. The peptides effect dose- and time-dependent activation of phosphorylase, trehalase and hexokinase activities that occur concomitantly with elevated levels of intracellular calcium. In addition, HT-I increases the accumulation of cyclic AMP in muscle cells.
authors.affiliation: Department of Biology, University of Waterloo, Ontario, Canada.
authors.forename: A P
authors.initials: AP
authors.lastname: Jahagirdar
authors.forename: J W
authors.initials: JW
authors.lastname: Gole
authors.forename: G L
authors.initials: GL
authors.lastname: Orr
authors.forename: T
authors.initials: T
authors.lastname: Viswanatha
authors.forename: R G
authors.initials: RG
authors.lastname: Downer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003058:Cockroaches / Q000201:enzymology*; D000242:Cyclic AMP / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D009132:Muscles / Q000187:drug effects / Q000201:enzymology*; D009479:Neuropeptides / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D006005:Phosphorylases / Q000378:metabolism*; D014198:Trehalase / Q000378:metabolism*
chemical_list: D009479:Neuropeptides; D010455:Peptides; C043192:glutamyl-valyl-asparaginyl-phenylalanyl-seryl-prolyl-asparaginyl-tryptophanamide; C043191:glutamyl-leucyl-threonyl-phenylalanyl-threonyl-prolyl-asparaginyl-tryptophanamide; D000242:Cyclic AMP; D006005:Phosphorylases; D006593:Hexokinase; D014198:Trehalase; D002118:Calcium