Possible role of aphidicolin-sensitive DNA polymerase(s) in N-methyl-N'-nitro-N-nitrosoguanidine and bleomycin induced cellular repair synthesis and virus reactivation.
Treatment of human embryonic cell line CLV 102 with N-methyl-N'-nitro-N-nitrosoguanidine or bleomycin was used to induce DNA repair synthesis. Both the repair synthesis induced by these agents and reactivation of UV-damaged pseudorabies virus were inhibited by aphidicolin.
Mazurowa
N
N
Serum and Vaccines Research Laboratories, Warszawa, Poland.
Anuszewska
E
E
Koziorowska
J
J
D016590:Aphidicolin / Q000494:pharmacology*; D001761:Bleomycin / Q000494:pharmacology*; D002460:Cell Line; D004260:DNA Repair / Q000187:drug effects*; D004259:DNA-Directed DNA Polymerase / Q000187:drug effects / Q000502:physiology*; D011558:Herpesvirus 1, Suid / Q000254:growth & development / Q000528:radiation effects; D006801:Humans; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D014466:Ultraviolet Rays; D014775:Virus Activation / Q000187:drug effects*
D001761:Bleomycin; D008769:Methylnitronitrosoguanidine; D016590:Aphidicolin; D004259:DNA-Directed DNA Polymerase