Ketamine potentiates 5-HT3 receptor-mediated currents in rabbit nodose ganglion neurones.
The interaction of ketamine with the 5-HT3 receptor of rabbit nodose ganglion neurones is described. Ketamine (3-30 microM) enhanced 5-HT3 receptor-mediated currents recorded under voltage-clamp conditions. This action did not appear to be related to the known effect of ketamine of inhibiting 5-HT uptake.
Peters
J A
JA
Department of Pharmacology & Clinical Pharmacology, Ninewells Hospital & Medical School, University of Dundee.
Malone
H M
HM
Lambert
J J
JJ
D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D007649:Ketamine / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009620:Nodose Ganglion / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*
D007473:Ion Channels; D011985:Receptors, Serotonin; D007649:Ketamine