[Mechanisms of selective inhibition of pancreatic secretion after increasing the enzymatic activity of duodenal contents].
In acute experiments on dogs it has been established that intraduodenal administration of trypsin, amylase and lipase induces selective inhibition of the introduced enzyme secretion by the pancreas. Atropine injection (0.2 mg/kg, intravenously, 4 times/h) removes the inhibitory effect of the introduced enzymes, the most pronounced atropine action being recorded in respect to trypsin. Intraduodenal trypsin administration decreases non-selective inhibitory effect of atropine on the stimulated secretion of the pancreas. It has been concluded that not only duodenal regulatory peptides but also the M-cholinergic mechanism participate in the selective inhibition.
Korot'ko
G F
GF
Baĭbekova
G D
GD
Nishanova
A A
AA
D000681:Amylases / Q000008:administration & dosage* / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D003864:Depression, Chemical; D004285:Dogs; D004386:Duodenum / Q000187:drug effects / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D008049:Lipase / Q000008:administration & dosage* / Q000037:antagonists & inhibitors / Q000378:metabolism; D008954:Models, Biological; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D014357:Trypsin / Q000494:pharmacology*
D001285:Atropine; D008049:Lipase; D000681:Amylases; D014357:Trypsin
K mekhanizmu selektivnogo tormozheniia pankreaticheskoĭ sekretsii pri povyshenii fermentativnoĭ aktivnosti duodenal'nogo soderzhimogo.