[Recombinant human erythropoietin (rh-EPO) in chronic, dialysis-dependent renal failure: effects on macro- and microcirculation and hematologic parameters].
Recombinant human erythropoietin (rh-EPO) has been shown to be effective in the treatment of renal anemia. Additionally, rh-EPO improves the hemostatic defect of uremia. On the other hand, a hypertensinogen effect and an increased risk for thrombosis have been reported in hemodialysis (HD) patients with rh-EPO. 20 HD patients in Homburg were recruited for a multicenter, placebo-controlled study (MF 3981), aiming to assess the risk of rh-EPO. Initially, 10 patients received rh-EPO at a dose of 3 x 80 U/kg body weight and week which was subsequently adjusted according to the hematocrit. After 6 months, the patients receiving placebo were changed to rh-EPO therapy. Clinical and laboratory data were obtained before, as well as 1, 3, 6 and 12 months after beginning of the study. Erythrocyte counts increased significantly in the rh-EPO group. Also, an increase of platelet count, fibrinogen and plasma viscosity was observed during rh-EPO. Tissue type plasminogen activator and plasminogen activator inhibitor as well as von-Willebrand-factor remained unchanged, although a shortening of the bleeding time was observed. Blood pressure and arterial blood flow were not influenced by rh-EPO.
Köhler
M
M
Abteilung für klinische Hämostaseologie, Universität des Saarlandes, Homburg/Saar.
Mörsdorf
S
S
Jung
F
F
Braun
B
B
Waldhausen
P
P
Pindur
G
G
Weber
U
U
Bosslet
R
R
Bambauer
R
R
Jutzler
G A
GA
D001809:Blood Viscosity / Q000187:drug effects*; D004906:Erythrocyte Count / Q000187:drug effects*; D004921:Erythropoietin / Q000008:administration & dosage* / Q000009:adverse effects; D006400:Hematocrit; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage; D006435:Renal Dialysis; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood
D011994:Recombinant Proteins; D004921:Erythropoietin
Rekombinates humanes Erythropoietin (rh-EPO) bei chronischer, dialysepflichtiger Niereninsuffizienz: Auswirkungen auf die Makro- und Mikrozirkulation und hämatologische Parameter.