Selective inhibition by magnosalin and magnoshinin, compounds from "Shin-i" (Flos magnoliae), of adjuvant-induced angiogenesis and granuloma formation in the mouse pouch.
Inhibitory effects of magnosalin and magnoshinin, compounds from the crude drug "Shin-i" (Flos magnoliae), on angiogenesis and pouch granuloma formation in mice induced by an adjuvant containing croton oil were investigated. The anti-chronic inflammatory effect of "shin-i" was caused by selective inhibition of angiogenesis by magnosalin and of granuloma formation by magnoshinin.
Kimura
M
M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical Pharmaceutical University, Japan.
Kobayashi
S
S
Luo
B
B
Kimura
I
I
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003503:Cyclobutanes / Q000494:pharmacology*; D005620:Freund's Adjuvant; D006099:Granuloma / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D006854:Hydrocortisone / Q000494:pharmacology; D017705:Lignans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009284:Naphthols / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010946:Plants, Medicinal / Q000032:analysis*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003503:Cyclobutanes; D017705:Lignans; D009284:Naphthols; C069674:magnosalin; C069675:magnoshinin; D005620:Freund's Adjuvant; D006854:Hydrocortisone