The effect of ATP-sensitive K+ channels on the electrical burst activity and insulin secretion in pancreatic beta-cells.
In recent years, the electrical burst activity of the insulin releasing pancreatic beta-cells has attracted many experimentalists and theoreticians, largely because of its functional importance, but also because of the nonlinear nature of the burst activity. The ATP-sensitive K+ channels are believed to play an important role in electrical activity and insulin release. In this paper, we show by computer simulation how ATP and antidiabetic drugs can lengthen the plateau fraction of bursting and how these chemicals can increase the intracellular Ca2+ level in the pancreatic beta-cell.
Chay
T R
TR
University of Pittsburgh, PA 15260.
Kim
J R
JR
Cook
D L
DL
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity / Q000187:drug effects* / Q000502:physiology; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism; D008433:Mathematics; D008564:Membrane Potentials / Q000187:drug effects* / Q000502:physiology; D008954:Models, Biological; D015221:Potassium Channels / Q000187:drug effects* / Q000502:physiology; D013453:Sulfonylurea Compounds / Q000494:pharmacology
D007328:Insulin; D015221:Potassium Channels; D013453:Sulfonylurea Compounds; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D005947:Glucose; D002118:Calcium