Recognition by class II alloreactive T cells of processed determinants from human serum proteins.
Alloreactive T cells recognize a complex composed of an allogeneic major histocompatibility complex (MHC) molecule and a peptide derived from the processing of nonpolymorphic proteins. A sizable fraction of MHC class II alloreactive T cells is shown to recognize peptides derived from constitutive processing of human serum proteins. One such epitope is a fragment of human serum albumin. This epitope bound selectively to the human class II molecule DRw11 and was constitutively present on antigen-presenting cells in vivo. These data indicate that, in the case of MHC class II, peptides involved in allorecognition may originate from exogenous proteins.
Panina-Bordignon
P
P
Basel Institute for Immunology, Switzerland.
Corradin
G
G
Roosnek
E
E
Sette
A
A
Lanzavecchia
A
A
D000938:Antigen-Presenting Cells / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D002460:Cell Line; D002999:Clone Cells; D000939:Epitopes / Q000032:analysis / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology*; D059810:HLA-DR Serological Subtypes; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D011994:Recombinant Proteins / Q000276:immunology; D012709:Serum Albumin / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D015704:CD4 Antigens; D000939:Epitopes; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C080766:HLA-DR11 antigen; D000949:Histocompatibility Antigens Class II; D011994:Recombinant Proteins; D012709:Serum Albumin