The grasping response in rats: interaction between gamma-type endorphins and haloperidol.
gamma-Type endorphins mimic neuroleptics in inducing a grasping response in rats. It was studied whether the haloperidol-induced grasping response was altered after blockade of gamma-type endorphin activity in the rat brain. To achieve this blockade rats were injected i.c.v. with gamma-endorphin antiserum or with a monoclonal anti-idiotype desenkephalin-gamma-endorphin antibody, which may bio-inactivate the gamma-type endorphins or block the putative receptors for gamma-type endorphins, respectively. The results showed that both treatments attenuated the haloperidol-induced grasping response, particularly 3 h after haloperidol treatment. The influence of these antibodies appeared to be specific, since other sera were without effect. Thus there may be an interaction between the endogenous gamma-type endorphin activity and the haloperidol-induced grasping response.
Van Furth
W R
WR
Department of Pharmacology, Rudolf Magnus Institute, Medical Faculty, University of Utrecht, The Netherlands.
Wiegant
V M
VM
Bruning
J W
JW
Van Ree
J M
JM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D004723:Endorphins / Q000276:immunology / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000037:antagonists & inhibitors; D018823:gamma-Endorphin
D000911:Antibodies, Monoclonal; D004723:Endorphins; D001615:beta-Endorphin; D018823:gamma-Endorphin; D006220:Haloperidol