Histology of midluteal corpus luteum and endometrium from clomiphene citrate-induced cycles.
OBJECTIVE
To determine the histologic development of midluteal corpus luteum (CL) and endometrium in normal fertile women after induction of ovulation with clomiphene citrate (CC). DESIGN, PATIENTS, INTERVENTIONS: Twelve normally cycling women planning to undergo an elective tubal ligation were treated with 50 to 150 mg of CC daily on days 5 through 9 of the cycle. Luteectomy and endometrial biopsy were performed simultaneously 7 days after the urinary luteinizing hormone surge.


RESULTS
Because polyovulation occurred in 10 of the 12 women, 22 CL and 12 endometrial biopsies were studied. Ten women had luteal and endometrial histology that were within 2 days of the ovulation to biopsy interval. The 2 remaining women had endometrial histology that lagged 3 days behind the chronological postovulatory date. In these women, out-of-phase endometrium occurred despite polyovulatory cycles in which two and three histologically normal CL lutea were present and associated with elevated progesterone concentrations.


CONCLUSIONS
In CC-induced ovulatory cycles: (1) midluteal CL histology is normal and (2) apparently out-of-phase preimplantation endometrium occurs in midluteal phase.
Yeko
T R
TR
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33606.
Nicosia
S M
SM
Maroulis
G B
GB
Bardawil
W A
WA
Dawood
M Y
MY
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology*; D003338:Corpus Luteum / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D004717:Endometrium / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle; D010060:Ovulation; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D012016:Reference Values; D013246:Sterilization, Tubal
D002996:Clomiphene; D011374:Progesterone; D007986:Luteinizing Hormone