[Immunohistochemical studies on bladder tumours. Immunohistochemical evaluation on intravesical therapy for bladder tumours].
The focus of my study was the immunohistochemical studies of tumour cells induced by ADM intravesical instillation therapy when stained by several antigens, those being; Carcinoembryonic antigen (CEA), Ferritin, Beta 2 Microglobulin (beta 2-MG), Keratin and Glycogen before and after the therapy. Then I discussed as to their value in indicating therapeutic efficacy. There were 18 cases of bladder cancer studied using the Peroxidase-antiperoxidase technique (PAP) of staining. Data indicated a 44.4% response rate following therapy with intravesical ADM. Immunohistochemical evaluation showed improvement as indicated by not staining with CEA. Also observed was no change and slightly diffuse staining with Keratin: and a decrease in all layers of Glycogen expression: However this could not be observed with the Ferritin or beta 2-MG. It is believed this demonstrates that immunohistochemical expressions of staining with CEA, Keratin, and Glycogen may be a sensitive indicator of a therapeutic response to intravesical ADM.
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Department of Urology, Fujigaoka Hospital, Showa University of Medicine.
D000283:Administration, Intravesical; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D004317:Doxorubicin / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D006003:Glycogen / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis*; D008297:Male; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000032:analysis*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D001613:beta 2-Microglobulin; D007633:Keratins; D004317:Doxorubicin; D006003:Glycogen