Lymphocytic active myocarditis characterized by numerous clusters of lymphocytes: a chronic variant of myocarditis?
We report three patients with a particular form of myocarditis characterized by numerous clusters of lymphocytes. Their common clinical manifestation was progressive and fatal heart failure with a 3- to 6-year duration. Atrioventricular and intraventricular conduction disturbances were observed in two patients. At necropsy, the hearts weighed 480, 530, and 430 gm, respectively, and showed marked dilatation of the bilateral ventricles and atria, with frequent mural thrombi. Histologic examination revealed numerous lymphocytic clusters and scattered foci of acute myocardial cell damage on a background of extensive fibrosis. We propose the term "chronic active myocarditis" to denote clinicopathologic characteristics of the present cases.
Okabe
M
M
Department of Internal Medicine, Fukuoka University, School of Medicine, Japan.
Fukuda
K
K
Nakashima
Y
Y
Hiroki
T
T
Arakawa
K
K
Kikuchi
M
M
D001281:Atrial Fibrillation / Q000175:diagnosis / Q000209:etiology; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000276:immunology / Q000473:pathology; D002908:Chronic Disease; D004562:Electrocardiography; D005260:Female; D005355:Fibrosis; D006327:Heart Block / Q000175:diagnosis / Q000209:etiology; D006331:Heart Diseases / Q000209:etiology / Q000473:pathology; D006333:Heart Failure / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008214:Lymphocytes; D008875:Middle Aged; D009205:Myocarditis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D009206:Myocardium / Q000276:immunology* / Q000473:pathology; D013610:Tachycardia / Q000175:diagnosis / Q000209:etiology; D013927:Thrombosis / Q000209:etiology / Q000473:pathology