title: Does ketotifen act by directly stimulating beta-adrenergic system?
abstract: Through this study we proved that the inhibitory effect ketotifen has on antigen-specific histamine release (ASHR) does not have any relation with beta-adrenergic system stimulation. However, it increases the inhibitory effect of histamine release caused by isoproterenol. Therefore, although ketotifen does not directly stimulate beta-adrenergic receptors to inhibit mediator secretion, its action correlates with the response produced through the stimulation of these receptors.
authors.affiliation: Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Pamplona, Spain.
authors.forename: J G
authors.initials: JG
authors.lastname: Castillo
authors.forename: F
authors.initials: F
authors.lastname: Santos
authors.forename: R
authors.initials: R
authors.lastname: Aguila
authors.forename: A
authors.initials: A
authors.lastname: Oehling
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000097:blood / Q000276:immunology; D004347:Drug Interactions; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007545:Isoproterenol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007665:Ketotifen / Q000494:pharmacology*; D008925:Mites; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects*
chemical_list: D000485:Allergens; D039741:Antigens, Dermatophagoides; D011943:Receptors, Adrenergic, beta; D011433:Propranolol; D007545:Isoproterenol; D007665:Ketotifen