[Normal immune function in centroblastic-centrocytic and centroblastic lymphoma].
We tested in vitro lymphocyte reactivity using 5 mitogens and 9 antigens, measured lymphocyte and lymphocyte subpopulation counts, granulocyte chemotaxis and adherence in 10 patients with centroblastic-centrocytic lymphoma (CB-CC), 7 patients with centroblastoma (CB) and 88 healthy controls. The control group could be divided into 3 clusters with significantly different lymphocyte reactivity by means of cluster and discrimination analysis (BMDP2N): 21 high-, 18 medium- and 49 low responders. Comparing lymphocyte reactivity of CB-CC and CB patients to each of the 3 immunofunctional different control groups yielded the surprising result that both malignant lymphomas are equivalent to the low responding control group and show a low, but still normal in vitro immune function.
Weisbach
V
V
Abteilung Innere Medizin, Universitätsklinikum Rudolf Vierchow-Standort Charlottenburg, Freie Universität Berlin.
Zeiler
T
T
Zingsem
J
J
Heuft
H G
HG
Mempel
W
W
Wilmanns
W
W
Eckstein
R
R
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000276:immunology*; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*
Normale Immunfunktion bei zentroblastisch-zentrozytischem (CB-CC) und zentroblastischem Lymphom (CB).