Comparative effects of cyclosporine A and FK-506 on endothelin secretion by a cultured renal cell line, LLC-PK1.
Cyclosporine A (CSA) stimulated endothelin secretion by a cultured renal epithelial cell line, LLC-PK1. A less nephrotoxic immunosuppressant (FK-506) did not affect endothelin secretion. Putative endothelin converting enzyme inhibitors or specific receptor antagonists may therefore prevent CSA nephrotoxicity.
Nakahama
H
H
First Department of Medicine, Osaka University Medical School, Japan.
Fukunaga
M
M
Kakihara
M
M
Horio
M
M
Fujiwara
Y
Y
Fukuhara
Y
Y
Ueda
N
N
Orita
Y
Y
Kamada
T
T
D002460:Cell Line; D016572:Cyclosporine / Q000494:pharmacology*; D016232:Endothelins / Q000378:metabolism*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D016559:Tacrolimus / Q000494:pharmacology*
D016232:Endothelins; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus