title: [Treatment with iloprost of critical ischemia of the lower limbs associated with cardiac insufficiency. Study of interaction with the pharmacokinetics of digoxin].
abstract: We have treated with intravenous iloprost twelve patients suffering from cardiac insufficiency compensated under oral digoxin (NYHA class II) associated with severe limb ischaemia due to arterial insufficiency. Our aim was to study its possible interaction on digoxin levels and to evaluate the long-term efficacy of iloprost. Although iloprost slowed the digoxin absorption by approximately one hour, we found no clinically significant difference between the digoxin pharmacokinetic data before and during treatment by iloprost. Moreover, 11 out of the 12 patients had a good clinical fate after the treatment, which persisted at 6 months. The pain disappeared in 4 and diminished in 7; and all skin ulcers healed. This improvement has lasted up to two and a half years in two patients. The clinical tolerance of iloprost was acceptable despite frequent headache and flushing associated with hypotension and nausea. We conclude that iloprost seems to be a very promising treatment of severe limb ischaemia when no intervention on the proximal arteries is possible. The patients on digoxin can continue their treatment without dose alteration while starting on iloprost.
authors.affiliation: Service de Médecine Interne, Hôpital Saint-Antoine, Paris.
authors.forename: J
authors.initials: J
authors.lastname: Cabane
authors.forename: I
authors.initials: I
authors.lastname: Penin
authors.forename: K
authors.initials: K
authors.lastname: Bouslama
authors.forename: A
authors.initials: A
authors.lastname: Benchouieb
authors.forename: P
authors.initials: P
authors.lastname: Giral
authors.forename: O
authors.initials: O
authors.lastname: Picard
authors.forename: M J
authors.initials: MJ
authors.lastname: Wattiaux
authors.forename: G
authors.initials: G
authors.lastname: Cheymol
authors.forename: G
authors.initials: G
authors.lastname: Souvignet
authors.forename: J C
authors.initials: JC
authors.lastname: Imbert
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004077:Digoxin / Q000493:pharmacokinetics*; D004347:Drug Interactions; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D016285:Iloprost / Q000378:metabolism / Q000627:therapeutic use*; D007511:Ischemia / Q000150:complications / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply; D008875:Middle Aged
chemical_list: D004077:Digoxin; D016285:Iloprost
vernacular_title: Traitement par Iloprost des ischémies critiques des membres inférieurs associées à une insuffisance cardiaque. Etude de l'interaction avec la pharmacocinétique de la digoxine.