[Activity of the kallikrein-kinin system of blood during combined treatment of patients with high and stable arterial hypertension].
The activity of the blood kallikrein-kinin system was evaluated in 18 patients with refractory arterial hypertension who received a combined therapy by using prostaglandin E2 (PGE2) infusions. PGE2 infusions produced a direct effect in modulating the vasoactive peptide system. There was activity mobilization at low baseline values of blood kallikrein and its inhibition at high values. The activating effect of PGE2 remained for further 2 weeks following the infusion. The response of the patients to previously low effective antihypertensive agents could be enhanced.
Petrina
S N
SN
Dzhusipov
A K
AK
Konakbaeva
T N
TN
Ligaĭ
Z N
ZN
Matiugina
L P
LP
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D015232:Dinoprostone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D016234:Kallikrein-Kinin System / Q000187:drug effects / Q000502:physiology*; D007610:Kallikreins / Q000097:blood*; D008875:Middle Aged; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage*; D000511:alpha-Macroglobulins / Q000032:analysis*
D000959:Antihypertensive Agents; D011459:Prostaglandins E, Synthetic; D000511:alpha-Macroglobulins; D002265:Carboxylic Ester Hydrolases; C019763:benzoylarginine ethyl esterase; D007610:Kallikreins; D015232:Dinoprostone
Aktivnost' kallikrein-kininovoĭ sistemy krovi pri kombinirovannoĭ terapii bol'nykh s vysokoĭ i stoĭkoĭ arterial'noĭ gipertonieĭ.