Metabolism and mechanism of action of 5-fluorouracil.
This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thymidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5,10-methylene tetrahydrofolate, FUTP.
Parker
W B
WB
Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, AL 35205.
Cheng
Y C
YC
D000818:Animals; D004247:DNA / Q000187:drug effects* / Q000378:metabolism; D019915:DNA Primase; D005472:Fluorouracil / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D011743:Pyrimidines / Q000378:metabolism; D012313:RNA / Q000187:drug effects* / Q000378:metabolism; D012316:RNA Nucleotidyltransferases / Q000378:metabolism
D011743:Pyrimidines; D012313:RNA; D004247:DNA; D019915:DNA Primase; D012316:RNA Nucleotidyltransferases; D005472:Fluorouracil