title: Applicability of the stimulus-T interval for antitachycardia pacing.
abstract: At the onset of tachycardia, the refractory period (RP) changes together with the tachycardia termination window. We evaluated dogs with total atrioventricular (AV) block to determine if stimulus-T interval (STI) can be used to adjust the coupling interval(s) of an antitachycardia pacemaker in relation to changes in RP. Endocardial STI was recorded continuously together with six surface ECG leads. Steady-state (greater than 2 min) RP was determined for drive cycle lengths (DCL) 400 msec and 900 msec. The test pulse (TP) coupling interval, with DCL 900 msec, was chosen to be equal to the RP of DCL 400 msec. DCL was then changed to 400 msec until TP captured. STI of DCL of beat before capture was gained was measured. DCL was then changed back to 900 msec and the interval determined when capture was lost. TP was then lengthened by 5 msec and the procedure repeated until TP captured immediately upon changing to DCL 400 msec.
  
  
  RESULTS
  The difference between RP at onset of pacing at DCL of 400 msec and RP when capture was achieved with the shortest coupling interval was 35-50 (mean 40) msec. This required 35-90 (mean 62) seconds. The correlation coefficient RP to STI was greater than 0.95.
  
  
  CONCLUSIONS
  (1) RP changed by as much as 35-50 msec at the onset of an abrupt increase in rate in a 35-90-second period; and (2) STI enables estimation of RP on a beat-to-beat basis. Capture can therefore be predicted from the previous beat and the coupling interval adjusted accordingly in an antitachycardia pacing mode.
authors.affiliation: Department of Cardiology, University Hospital Maastricht, The Netherlands.
authors.forename: K
authors.initials: K
authors.lastname: den Dulk
authors.forename: H
authors.initials: H
authors.lastname: Leerssen
authors.forename: M
authors.initials: M
authors.lastname: Vos
authors.forename: J
authors.initials: J
authors.lastname: Leunissen
authors.forename: W
authors.initials: W
authors.lastname: Dassen
authors.forename: J
authors.initials: J
authors.lastname: Kersemakers
authors.forename: M
authors.initials: M
authors.lastname: Begemann
authors.forename: H
authors.initials: H
authors.lastname: Wellens
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004285:Dogs; D004562:Electrocardiography; D005069:Evaluation Studies as Topic; D005260:Female; D006327:Heart Block / Q000503:physiopathology; D008297:Male; D009200:Myocardial Contraction / Q000502:physiology; D010138:Pacemaker, Artificial; D012032:Refractory Period, Electrophysiological / Q000502:physiology; D013610:Tachycardia / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors