title: Tissue kallikrein stimulates mucociliary activity in the rabbit maxillary sinus.
abstract: The in vivo effect of tissue kallikrein on the mucociliary activity in the rabbit maxillary sinus was investigated administering the substance (0.1-5 mU/kg) via a. maxillaris and recording the response with a non-invasive photoelectric technique. Tissue kallikrein accelerated mucociliary activity, with a maximum response for the dose 5 mU/kg (33.7 +/- 13.4% from basal levels, n = 5). The effect had a latency of abut 1 min, with a peak within 2-3 min after the beginning of the administration. The response to tissue kallikrein displayed tachyphylaxis with a second dose producing a weaker response. Pretreatment with the protease inhibitor aprotinin (10,000 KIU bolus/kg) inhibited the action of tissue kallikrein. Tissue kallikrein probably stimulates mucociliary activity by producing lysylbradykinin from kininogen. Bradykinin has in an earlier study been shown to stimulate mucociliary activity.
authors.affiliation: Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Lindberg
authors.forename: H
authors.initials: H
authors.lastname: Olsson
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000494:pharmacology; D005260:Female; D007609:Kallidin / Q000096:biosynthesis; D007610:Kallikreins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D007704:Kininogens / Q000378:metabolism; D008297:Male; D008443:Maxillary Sinus / Q000502:physiology*; D009079:Mucociliary Clearance / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors; D020840:Tissue Kallikreins
chemical_list: D007704:Kininogens; D007609:Kallidin; D007611:Aprotinin; D007610:Kallikreins; D020840:Tissue Kallikreins