title: Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.
abstract: Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.
authors.affiliation: Eukaryotic Regulatory Biology Program, University of California, San Diego, La Jolla 92093-0648.
authors.forename: X
authors.initials: X
authors.lastname: He
authors.forename: R
authors.initials: R
authors.lastname: Gerrero
authors.forename: D M
authors.initials: DM
authors.lastname: Simmons
authors.forename: R E
authors.initials: RE
authors.lastname: Park
authors.forename: C J
authors.initials: CJ
authors.lastname: Lin
authors.forename: L W
authors.initials: LW
authors.lastname: Swanson
authors.forename: M G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015815:Cell Adhesion Molecules / Q000235:genetics*; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000378:metabolism*; D007031:Hypothalamus; D008969:Molecular Sequence Data; D008970:Molecular Weight; D018993:Myelin P0 Protein; D009185:Myelin Proteins / Q000235:genetics*; D050816:Octamer Transcription Factor-6; D009841:Oligonucleotides / Q000737:chemistry; D011401:Promoter Regions, Genetic; D051381:Rats; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D015815:Cell Adhesion Molecules; D004268:DNA-Binding Proteins; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D009841:Oligonucleotides; C494179:Pou3f1 protein, rat; D014157:Transcription Factors; D050816:Octamer Transcription Factor-6