The effect of basic fibroblast growth factor on the neovascularisation process: skin flap survival and staged flap transfers.
Forty-two male Sprague-Dawley rats were utilised to determine whether the angiogenic property of basic fibroblast growth factor (bFGF) could be applied to improve the survival of the ischaemic portion of a random skin flap and to accelerate the process of staged flap transfer. In the ischaemic flap model, bFGF enhanced the development of vascular connections between the bed and the flap and prevented marginally perfused areas from undergoing necrosis. No effect was observed in the staged reconstruction model using the same dosage of bFGF. A speculative explanation is given for the differential effect of BFGF in these two models. The application of angiogenic factors may improve the survival of the random portion of skin flaps. Further investigations are needed to determine whether exogenously applied angiogenic factors can have a beneficial effect in staged flap reconstructions.
Khouri
R K
RK
Institute of Reconstructive Plastic Surgery, New York University Medical Centre, New York.
Brown
D M
DM
Leal-Khouri
S M
SM
Tark
K C
KC
Shaw
W W
WW
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply*; D013524:Surgical Flaps / Q000379:methods*
D043925:Angiogenesis Inducing Agents; D016222:Fibroblast Growth Factor 2