Effect of hippurate on glucose utilization in rat kidney cortex slices.
Hippurate action on glucose utilization was evaluated in rat kidney cortex slices. Studies have shown the following. (1) Hippurate inhibits markedly basal as well as insulin-stimulated glucose utilization and basal gluconeogenesis. (2) Ca deficiency and specific Ca channel blockers diltiazem and isradipine abolish the hippurate inhibition of glucose utilization. (3) K+ channel blockers, i.e. the increased K+ concentration in incubation medium, procaine and sulfonylurea drugs also abolish the hippurate inhibition of glucose utilization. It is concluded that hippurate and benzoate operate through the ATP-dependent K+ channel.
Spustová
V
V
Medical Bionics Research Institute, Bratislava, Czechoslovakia.
Dzúrik
R
R
D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D019817:Benzoic Acid; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D004110:Diltiazem / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005943:Gluconeogenesis / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006626:Hippurates / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology; D017275:Isradipine; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001565:Benzoates; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D006626:Hippurates; D007328:Insulin; D011725:Pyridines; D019817:Benzoic Acid; D004110:Diltiazem; D005947:Glucose; C030514:hippuric acid; D017275:Isradipine