title: [The eosinophil and Entamoeba histolytica. II. Testicular amebic lesions produced in eosinophilic rats].
abstract: Even though eosinophiles are not characteristic of amebiasis, polymorphonuclear eosinophilic cells are regularly found in the inflammatory lesion which occurs in the early phases of amebic invasion. To acquire better knowledge of the intervention of these cells when confronted with E. histolytica, testicular lesions were produced by means of direct injection of amebas in rats with eosinophilia. Eosinophilia (greater than or equal to 4%) was induced in male Sprague Dawley rats by an intravenous injection of Sephadex G200 suspension. Later, both the eosinophilic and normal (control) rats were challenged with an intratesticular injection (on the left side) of 2 x 10(6) amebas of the virulent strain HM1-IMSS. The other testicle was injected with BFS-A to serve as control. The testicles were removed 5 hours later and evaluated histologically. The size and celullarity of the testicular lesions produced by the ameba on both eosinophilic and controls were similar, whereas lesions were not found in testicles injected with BSF-A. Within the limits of our experimental model, the results suggest that eosinophils do not contribute substantially to the genesis of tissue lesions produced by E. histolytica.
authors.affiliation: División de Inmunología, CMN-IMSS, México, D.F.
authors.forename: M
authors.initials: M
authors.lastname: López-Osuna
authors.forename: R
authors.initials: R
authors.lastname: Pérez-Tamayo
authors.forename: P
authors.initials: P
authors.lastname: Frenk
authors.forename: R
authors.initials: R
authors.lastname: Kretschmer
mesh_terms: D000818:Animals; D003911:Dextrans / Q000633:toxicity; D004748:Entamoeba histolytica / Q000472:pathogenicity / Q000502:physiology; D004749:Entamoebiasis / Q000150:complications / Q000473:pathology*; D004802:Eosinophilia / Q000139:chemically induced / Q000150:complications; D004804:Eosinophils / Q000502:physiology*; D007267:Injections; D008297:Male; D009920:Orchitis / Q000469:parasitology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003911:Dextrans; C025614:sephadex
vernacular_title: El eosinófilo y la Entamoeba histolytica. II. Lesiones testiculares amibianas producidas en ratas eosinofílicas.