Hematologic data in 825 cases of beta-thalassemia trait in Spain.
We present the hematologic data of 825 cases of beta-thalassemia trait (687 cases of beta-thalassemia trait and 138 cases of delta beta-thalassemia trait). There were no significant differences between the red cell indices of the patients with beta and delta beta-thalassemia trait. In patients with beta-thalassemia trait, MCV was significantly reduced in 97% of the males and 99% of the females. All the patients with delta beta-thalassemia trait showed low MCV values. Red cell morphology was altered in the vast majority of cases, with basophilic stippling in 96% of the patients. Most patients came from provinces with the highest incidence of malaria in the past.
Calero
F
F
Servicio de Hematologia, Hospital Universitario San Carlos, Universidad Complutense de Madrid, Spain.
Villegas
A
A
Porres
A
A
Valverde
F
F
del Potro
E
E
Sánchez
P
P
Luque
J M
JM
Espinós
D
D
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005319:Fetal Hemoglobin / Q000378:metabolism; D006443:Hemoglobin A2 / Q000378:metabolism; D006579:Heterozygote; D006801:Humans; D008288:Malaria / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D013030:Spain / Q000453:epidemiology; D013789:Thalassemia / Q000097:blood* / Q000235:genetics
D006443:Hemoglobin A2; D005319:Fetal Hemoglobin