Beta 2-glycoprotein-1 (apolipoprotein H) excretion in chronic renal tubular disorders: comparison with other protein markers of tubular malfunction.
Urinary beta 2-glycoprotein-1 was measured in 60 patients with conditions recognised as causing renal tubular impairment and compared with established markers of early tubular malfunction. Increased beta 2-glycoprotein-1 excretion was found in 49 (82%) of the subjects; raised excretion of alpha 1-microglobulin, retinol-binding protein, and beta 2-microglobulin was found in 46 (77%), 45 (75%), and 31 (52%), respectively, and increased urinary N-acetyl-beta-D-glucosaminidase activity in 32 of 54 of the subjects (59%). The increase was particularly pronounced in those with proximal tubule malfunction, although considerable variation occurred. beta 2-glycoprotein-1 was shown to be stable in urine over the physiological pH range, and it is concluded that its measurement provides a means of detecting chronic malfunction of the renal tubules that is marginally more sensitive than assays of alpha 1-microglobulin or retinol-binding protein, and more reliable than assays of beta 2-microglobulin or N-acetyl-beta-D-glucosaminidase.
Lapsley
M
M
Department of Chemical Pathology, University College and Middlesex School of Medicine, London.
Sansom
P A
PA
Marlow
C T
CT
Flynn
F V
FV
Norden
A G
AG
D000118:Acetylglucosaminidase / Q000652:urine; D000293:Adolescent; D000328:Adult; D000368:Aged; D000510:Alpha-Globulins / Q000652:urine; D002908:Chronic Disease; D005260:Female; D006023:Glycoproteins / Q000652:urine*; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology / Q000652:urine*; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012177:Retinol-Binding Proteins / Q000652:urine; D053482:beta 2-Glycoprotein I; D001613:beta 2-Microglobulin / Q000652:urine
D000510:Alpha-Globulins; D006023:Glycoproteins; D012177:Retinol-Binding Proteins; C016001:alpha-1-microglobulin; D053482:beta 2-Glycoprotein I; D001613:beta 2-Microglobulin; D000118:Acetylglucosaminidase