Electrochemotherapy of spontaneous mammary tumours in mice.
Electrochemotherapy delivers external electric pulses to the tumour site to induce local potentiation of the antitumour activity of intramuscular injections of bleomycin. C3H/Bi mice with spontaneous mammary carcinomas received weekly injections of 50 micrograms bleomycin followed by electric pulses 30 min later. All the 38 tumours treated exhibited at least a partial regression. 23 complete remissions were observed, 3 of which were cures. One difficulty in assessing the cure rate in this model is that frequent parallel or sequential tumours cause early death. Electrochemotherapy appears similarly efficient in spontaneous tumours as in previously studied transplanted tumours.
Belehradek
J
J
Laboratoire de Biochimie-Enzymologie, Institute Gustave Roussy, Villejuif, France.
Orlowski
S
S
Poddevin
B
B
Paoletti
C
C
Mir
L M
LM
D000818:Animals; D001761:Bleomycin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004599:Electric Stimulation Therapy; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H
D001761:Bleomycin