Is "tumor necrosis factor" the major effector of pulmonary fibrosis?
A major role of TNF in pulmonary fibrosis is supported by the following evidences obtained from pulmonary fibrosis induced in mice by bleomycin or silica particles; 1) these diseases are associated with a marked and lasting increase of the TNF mRNA within the lung, 2) they can be prevented by a treatment with anti TNF antibody or aggravated by a perfusion of mouse recombinant TNF, 3) an infusion of TNF-alpha can reproduce the alterations observed during pulmonary fibrosis such as growth of fibroblasts, collagen deposition, cell necrosis.
Piguet
P F
PF
Department of Pathology, University of Geneva, CMU, Switzerland.
D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D001761:Bleomycin / Q000633:toxicity; D003094:Collagen / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000633:toxicity; D008168:Lung / Q000737:chemistry; D051379:Mice; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000503:physiopathology*; D012333:RNA, Messenger / Q000032:analysis; D011994:Recombinant Proteins / Q000494:pharmacology; D012829:Silicosis / Q000150:complications; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*
D000906:Antibodies; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D001761:Bleomycin; D003094:Collagen