IL-6 induced by IL-1 inhibits malaria pre-erythrocytic stages but its secretion is down-regulated by the parasite.
The capacity of IL-6 to mediate the antiparasitic activity of IL-1 on intrahepatic development of malaria parasite was demonstrated. The comparisons of IL-6 levels in infected and noninfected hepatocyte cultures, either purified or enriched with nonparenchymal cells and stimulated by IL-1 or IL-6, indicate that subtle interactions exist between intrahepatocytic development of Plasmodium yoelii and liver synthesis of IL-6. During its intrahepatic multiplication, the parasite causes a decline in IL-6 production. IL-6 mRNA was not detected in the livers of infected mice during development of either hepatic or blood stage parasites although IL-6 activity was found in the sera during both stages.
Pied
S
S
INSERM U 313 Groupe Pitié-Salpétrière, Paris, France.
Civas
A
A
Berlot-Picard
F
F
Renia
L
L
Miltgen
F
F
Gentilini
M
M
Doly
J
J
Mazier
D
D
D000818:Animals; D015152:Blotting, Northern; D002478:Cells, Cultured; D004912:Erythrocytes / Q000469:parasitology; D015870:Gene Expression; D007375:Interleukin-1 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000502:physiology*; D008099:Liver / Q000469:parasitology; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008809:Mice, Inbred C3H; D010967:Plasmodium yoelii / Q000254:growth & development / Q000276:immunology*; D012333:RNA, Messenger / Q000235:genetics
D007375:Interleukin-1; D015850:Interleukin-6; D012333:RNA, Messenger