Renal cell carcinoma in children: histology, immunohistochemistry, and follow-up of 10 cases.
Ten renal cell carcinomas in children under 15 years were investigated. The average age was 122.5 months and the girls predominated in our cases (7 girls, 3 boys). By using the classification of Thoenes et al., Pathol Res Pract 181: 125-143, 1986 a predominance of clear cell-eosinophilic tumor cell type and of the tubulopapillary growth pattern was found. Immunohistochemistry revealed a heterogeneity of cytokeratin expression. By using the monoclonal antibodies Cam 5.2 and KL 1, cytokeratins were found in 7 cases each. The other 4 cytokeratin antibodies used were less sensitive. The expression of cytokeratin 13 in 3 cases suggested a more complex histogenesis than assumed. Vimentin was found in 3 tumors, but an association to a higher grade (G) of malignancy was not found in these cases. One tumor expressed the Tamm-Horsfall-protein, which is predominantly found in the distal tubule of the normal kidney. In summary the results of immunohistochemistry characterized the great heterogeneity of these tumors. Follow-up information was available in 9 cases. All patients with G I- and G II-tumors were free of disease after an average time of 39.6 months (mean 27 months). Two of the 3 cases with G III-tumors died after 9 and 15 months, despite additional chemo- or radiotherapy. Therefore tumors of grade I and II of the Thoenes classification seem to have a good prognosis.
Leuschner
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I
Abt. Paidopathologie, Universität Kiel, Federal Republic of Germany.
Harms
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Schmidt
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D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D000293:Adolescent; D000906:Antibodies; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004801:Eosine Yellowish-(YS); D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D037102:Lectins; D008297:Male; D011379:Prognosis; D013194:Staining and Labeling; D009396:Wilms Tumor / Q000378:metabolism / Q000473:pathology*
D000906:Antibodies; D037102:Lectins; D007633:Keratins; D004801:Eosine Yellowish-(YS)