title: Naturally-occurring peptide antigens derived from the MHC class-I-restricted processing pathway.
abstract: The extraction of naturally-processed peptides from MHC class I glycoproteins has paved the way for a major advance in the understanding of the antigen processing pathway that ultimately induces cytotoxic T-cell responses. Here, Olaf Rötzschke and Kirsten Falk review these new developments and discuss their findings in terms of a novel hypothesis of MHC class-I-restricted processing.
authors.affiliation: Max-Planck-Institut für Biologie, Abteilung Immungenetik, Tübingen, FRG.
authors.forename: O
authors.initials: O
authors.lastname: Rötzschke
authors.forename: K
authors.initials: K
authors.lastname: Falk
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology* / Q000378:metabolism; D000941:Antigens / Q000276:immunology* / Q000378:metabolism; D000956:Antigens, Viral / Q000276:immunology / Q000378:metabolism; D016384:Consensus Sequence; D010450:Endopeptidases / Q000378:metabolism; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D008954:Models, Biological; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology* / Q000378:metabolism; D011487:Protein Conformation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D000941:Antigens; D000956:Antigens, Viral; D000939:Epitopes; D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; D010446:Peptide Fragments; D010450:Endopeptidases