Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast.
Fourteen cases of sarcomatoid carcinomas of breast were evaluated by means of a silver technique that selectively stains proteins located in the nucleolar organizer regions (Ag-NORs). The mean area of Ag-NORs (MNORA) was in each case quantitatively analyzed by means of an automated image analyzer. Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases.
Eusebi
V
V
Institute of Anatomic Pathology, University of Bologna, Italy.
Cattani
M G
MG
Lamovec
J
J
Treré
D
D
Ceccarelli
C
C
Veronesi
P
P
Clemente
C
C
Derenzini
M
M
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry* / Q000401:mortality; D002277:Carcinoma / Q000737:chemistry* / Q000401:mortality; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D012189:Retrospective Studies; D012509:Sarcoma / Q000737:chemistry; D012834:Silver; D013194:Staining and Labeling / Q000379:methods; D015996:Survival Rate
D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D012834:Silver