title: [Value of early amniocentesis for prenatal diagnosis in the first trimester of pregnancy].
abstract: For the prenatal diagnosis of the fetal status, amniocentesis was performed in 9-12-week pregnancy in 31 females at risk for birth of a baby with chromosomal abnormalities and congenital malformations of the central nervous system. There were no difficulties in carrying out the procedure. A balanced translocation-bearing female was found to have a fetal chromosomal abnormality. Her pregnancy was interrupted at the 11th week; the prenatal diagnosis was evidenced by cytogenetic examination of the abortion specimen. The amniotic fluid alpha-fetoprotein estimated by radioimmunoassay ranged from 15-18 to 550-620 ng/ml. The findings suggest that early amniocentesis may be useful in the prenatal diagnosis of the fetal status and further evidence should be accumulated.
authors.forename: V A
authors.initials: VA
authors.lastname: Bakharev
authors.forename: N A
authors.initials: NA
authors.lastname: Karetnikova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Polesterov
authors.forename: L P
authors.initials: LP
authors.lastname: Lisova
authors.forename: Iu R
authors.initials: IuR
authors.lastname: Iantovskiĭ
mesh_terms: D000649:Amniocentesis / Q000379:methods*; D000653:Amniotic Fluid / Q000737:chemistry / Q000166:cytology*; D000013:Congenital Abnormalities / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins
vernacular_title: Znachenie rannego amniotsenteza dlia prenatal'noĭ diagnostiki v I trimestre beremennosti.