title: [HCG producing malignant teratoma of the testis: a rare cause of precocious isosexual maturation in boys].
abstract: Human chorionic gonadotropin (HCG) from a testicular tumor histologically diagnosed from its metastases to be a malignant teratoma induced elevated testosterone levels and subsequent precocious isosexual development in a 12-year-old boy. The endocrinologic consequences of long term ectopic HCG production in the prepubertal male are discussed. The case report illustrates the value of HCG serum levels as a marker for tumor activity.
authors.affiliation: Abteilung für Hämatologie und Onkologie, Universität Essen, GHS.
authors.forename: B
authors.initials: B
authors.lastname: Kremens
authors.forename: B P
authors.initials: BP
authors.lastname: Hauffa
authors.forename: K
authors.initials: K
authors.lastname: Metz
mesh_terms: D002648:Child; D006063:Chorionic Gonadotropin / Q000097:blood / Q000378:metabolism*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009362:Neoplasm Metastasis; D009384:Paraneoplastic Endocrine Syndromes / Q000097:blood; D010446:Peptide Fragments / Q000097:blood / Q000378:metabolism*; D011629:Puberty, Precocious / Q000097:blood / Q000209:etiology*; D012186:Retroperitoneal Neoplasms / Q000097:blood / Q000556:secondary; D013724:Teratoma / Q000097:blood / Q000378:metabolism* / Q000556:secondary; D013736:Testicular Neoplasms / Q000097:blood / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D013739:Testosterone
vernacular_title: HCG-produzierendes malignes Teratom des Hodens: Eine seltene Ursache der vorzeitigen isosexuellen Geschlechtsentwicklung beim Jungen.