title: Chronic myelomonocytic leukaemia (an analysis of fourteen consecutive cases).
abstract: Fourteen consecutive cases of chronic myelomonocytic leukaemia aged 6 to 73 (mean 40.5) years were reviewed to define the natural history of the disease and the risk of acute transformation. The common presenting features included anaemia, fever, purpura, and bleeding tendencies. Abnormal karyotypes were seen in 4 of 6 patients subjected to cytogenetic analysis. Low dose cytosine arabinoside achieved complete remission in two and partial remission in one, of the four patients treated with this modality. The mean survival was 5.6 (range 2-12) months and two patients) evolved to acute myeloid leukaemia. The long term survival with the present form of therapy in chronic myelomonocytic leukaemia is poor.
authors.affiliation: Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay.
authors.forename: U A
authors.initials: UA
authors.lastname: Athale
authors.forename: R
authors.initials: R
authors.lastname: Nair
authors.forename: R
authors.initials: R
authors.lastname: Iyer
authors.forename: C N
authors.initials: CN
authors.lastname: Nair
authors.forename: P
authors.initials: P
authors.lastname: Kadam
authors.forename: S H
authors.initials: SH
authors.lastname: Advani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D007194:India; D015477:Leukemia, Myelomonocytic, Chronic / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D005319:Fetal Hemoglobin