[Participation of the prostacyclin-thromboxane system in the mechanisms of prevention of arrhythmia caused by occlusion of the coronary artery in adapted rats].
It was found, that adaptation of rats to cold and physical exercise prevented ventricular fibrillation, caused by the occlusion of the left anterior coronary artery. An adaptation to cold only or to physical exercise do not prevent ventricular arrhythmias. An significant increase of prostacyclin/thromboxane index in plasma and heats was estimated in rats adapted to cold and physical exercise in relation to control non-adapted group in condition of functional rest or acute myocardial ischemia. It was assumed that an increase of prostacyclin/thromboxane ratio has a significant role in antiarrhythmic action of adaptation.
Maslov
L N
LN
Khaliulin
I G
IG
Dvurechenskaia
G Ia
GIa
Barabash
N A
NA
Lishmanov
Iu B
IuB
D015121:6-Ketoprostaglandin F1 alpha / Q000502:physiology*; D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D005117:Cardiac Complexes, Premature / Q000209:etiology / Q000517:prevention & control*; D003080:Cold Temperature; D003327:Coronary Disease / Q000150:complications / Q000503:physiopathology*; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D013550:Swimming; D013929:Thromboxane B2 / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000209:etiology / Q000517:prevention & control*
D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha
Uchastie prostatsiklin-tromboksanovoĭ sistemy v mekhanizmakh preduprezhdeniia aritmiĭ, vyzvannykh koronarookkliuzieĭ u adaptirovannykh krys.