Prostatic acid phosphatase, beta-glucuronidase and prostate specific antigen assays in fine needle aspirates from benign and malignant prostates.
Enzymatic assays for tartrate-sensitive acid phosphatase and beta-glucuronidase, and radio-immunoassay for prostate-specific antigen, were modified for application to fine-needle aspirate samples from benign and malignant human prostates. When compared to samples from benign prostates, the ratio of acid phosphatase to beta-glucuronidase activities was significantly decreased in needle aspirates from malignant prostates. Prostate-specific antigen values in the aspirates did not correlate with malignancy.
Erickson
D R
DR
Department of Surgery, University of Texas Health Science Center, San Antonio.
Hlavinka
T C
TC
Rockwood
A P
AP
Metter
J D
JD
Novicki
D E
DE
Fried
M G
MG
D000135:Acid Phosphatase / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000737:chemistry*; D001707:Biopsy, Needle; D004796:Clinical Enzyme Tests / Q000379:methods*; D005966:Glucuronidase / Q000032:analysis*; D006801:Humans; D008297:Male; D011467:Prostate / Q000201:enzymology* / Q000276:immunology / Q000473:pathology; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D000135:Acid Phosphatase; D005966:Glucuronidase; D017430:Prostate-Specific Antigen