title: Flecainide therapy in patients treated for supraventricular tachycardia with near normal left ventricular function.
abstract: Concerns about the safety and efficacy of class IC antiarrhythmic agents have arisen as a result of the recent CAST data. We reviewed records of 175 consecutive patients treated with flecainide between July 1, 1988 and July 5, 1989. One hundred ten patients with normal or mildly impaired left ventricular function and symptomatic supraventricular arrhythmias were identified. Follow-up data were obtained on 102 patients for a mean of 14 months. The average duration of flecainide therapy was 13 months. Tachyarrhythmias treated included atrial fibrillation/flutter, atrioventricular reentry, and atrioventricular nodal reentry. Flecainide provided effective antiarrhythmic therapy in 62% of the patients and was discontinued in 38% of the patients. Left atrial size did not predict treatment failure. Two patients developed proarrhythmic events (nonsustained ventricular tachycardia). There were no deaths during the follow-up period. In conclusion, flecainide provides safe and effective therapy for supraventricular tachyarrhythmias in patients with normal or mildly impaired left ventricular function.
authors.affiliation: Cleveland Clinic Foundation, OH 44195-5001.
authors.forename: M M
authors.initials: MM
authors.lastname: Hughes
authors.forename: R G
authors.initials: RG
authors.lastname: Trohman
authors.forename: T W
authors.initials: TW
authors.lastname: Simmons
authors.forename: L W
authors.initials: LW
authors.lastname: Castle
authors.forename: B L
authors.initials: BL
authors.lastname: Wilkoff
authors.forename: V A
authors.initials: VA
authors.lastname: Morant
authors.forename: J D
authors.initials: JD
authors.lastname: Maloney
mesh_terms: D001281:Atrial Fibrillation / Q000188:drug therapy*; D001282:Atrial Flutter / Q000188:drug therapy*; D005260:Female; D005424:Flecainide / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D005424:Flecainide