After superovulation-intrauterine insemination fails: the prognosis for treatment by gamete intrafallopian transfer/pronuclear stage transfer.
OBJECTIVE
To determine the prognosis for gamete intrafallopian transfer (GIFT)/pronuclear stage transfer (PROST) treatment after prior superovulation-intrauterine insemination (IUI).


METHODS
Matched, retrospective.


METHODS
Outpatient university endocrine-infertility program.


METHODS
One hundred forty-four women matched for infertility factors and age were studied according to the following three treatment groups: superovulation-IUI only, GIFT/PROST only, or GIFT/PROST after superovulation-IUI.


METHODS
Per cycle and cumulative pregnancy rates (PRs) were compared utilizing life table analysis.


RESULTS
Cumulative PRs (0.408) for superovulation-IUI only were lower than initial (0.469) and cumulative (0.802) cycle fecundity of GIFT/PROST (P = 0.002). Per cycle and cumulative PRs did not differ between GIFT/PROST only versus GIFT/PROST after superovulation-IUI.


CONCLUSIONS
Gamete intrafallopian transfer/PROST may be cost-effective when compared with superovulation-IUI. The prognosis for GIFT/PROST success is not negatively affected by earlier superovulation-IUI treatment failure.
Robinson
D
D
Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City 52242-1009.
Syrop
C H
CH
Hammitt
D G
DG
D000328:Adult; D005260:Female; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D007315:Insemination, Artificial; D008297:Male; D011247:Pregnancy; D012099:Reproductive Techniques; D012189:Retrospective Studies; D013480:Superovulation; D016896:Treatment Outcome; D014599:Uterus