Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia.
Administration of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine; PAF) did not alter the rate of triacylglycerol entry into the plasma. The gastrointestinal absorption of [1-14C]triolein was, however, inhibited by PAF, yet there was increased accumulation of [14C]lipid in the plasma and hypertriglyceridaemia. The half-life of injected [9,10(n)-3H]triolein in the plasma increased by 47%, and there was decreased accumulation of [3H]lipid in brown adipose tissue. This was accompanied by a decrease in lipoprotein lipase activity. The hypertriglyceridaemia induced by PAF appears to be mainly due to decreased peripheral removal, one important site affected being brown adipose tissue.
Evans
R D
RD
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford, U.K.
Ilic
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V
Williamson
D H
DH
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D004655:Emulsions; D005260:Female; D015228:Hypertriglyceridemia / Q000209:etiology* / Q000378:metabolism; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D010972:Platelet Activating Factor / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D004655:Emulsions; D010972:Platelet Activating Factor; D014280:Triglycerides; D002245:Carbon Dioxide