title: Gd-DOTA-enhanced MR imaging and color Doppler US of renal allograft necrosis.
abstract: In 21 recipients of renal transplants suspected of allograft necrosis, the authors correlated the results of imaging to pathologic and histologic data in order to describe the magnetic resonance (MR) imaging and color Doppler ultrasonographic (US) characteristics of infarction. All patients underwent MR imaging performed with and without gadolinium tetraazacyclododecanetetraacetic acid (DOTA) and color Doppler US. Nonenhanced T1-weighted images showed no obvious changes, whereas nonenhanced T2-weighted images demonstrated a slight increase in signal intensity in areas of ischemic necrosis and low or heterogeneous signal intensity in areas of hemorrhagic necrosis. Gd-DOTA-enhanced MR images showed no contrast material uptake in infarcted areas. Color Doppler US characteristics of infarction included absence of Doppler signal and alteration of the cortical echogenic structure, particularly in cases of ischemic necrosis. Color Doppler US allows measurement of vascular resistance and assessment of intrarenal vasculature and the renal pedicle. Gd-DOTA-enhanced MR imaging is useful in confirming the diagnosis of infarction and provides an accurate evaluation of the extent of the infarct.
authors.affiliation: Department of Radiology, Hôpital Necker, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Hélénon
authors.forename: E
authors.initials: E
authors.lastname: Attlan
authors.forename: C
authors.initials: C
authors.lastname: Legendre
authors.forename: S
authors.initials: S
authors.lastname: Hanna
authors.forename: A
authors.initials: A
authors.lastname: Denys
authors.forename: M
authors.initials: M
authors.lastname: Souissi
authors.forename: H
authors.initials: H
authors.lastname: Kreis
authors.forename: J F
authors.initials: JF
authors.lastname: Moreau
mesh_terms: D000328:Adult; D000368:Aged; D003116:Color; D003287:Contrast Media; D004301:Doppler Effect; D005260:Female; D005682:Gadolinium; D006084:Graft Rejection; D006571:Heterocyclic Compounds; D006801:Humans; D007089:Image Enhancement; D007238:Infarction / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology*; D007673:Kidney Cortex Necrosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D016030:Kidney Transplantation / Q000000981:diagnostic imaging* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009942:Organometallic Compounds; D013927:Thrombosis / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium