Conversion of bromperidol to reduced bromperidol in human liver.
Bromperidol (BRP) is an analog of haloperidol, a potent butyrophenone neuroleptic. Reductive conversion of BRP carbonyl group to reduced bromperidol (RBRP) was confirmed in vitro using human liver. This NADPH-dependent reduction of BRP showed a similar inhibition pattern and Michaelis constants to haloperidol carbonyl reductase.
Someya
T
T
Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
Inaba
T
T
Tyndale
R F
RF
Tang
S W
SW
Takahashi
S
S
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006220:Haloperidol / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D010084:Oxidation-Reduction
D000429:Alcohol Oxidoreductases; D006220:Haloperidol; C006820:bromperidol