Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheep.
The thermal and mechanical analgesic profile of buprenorphine at a dose rate of 1.5 micrograms/kg i.v. was investigated in five sheep. This dose produced significant analgesia for 40 min against the thermal stimulus, but no mechanical antinociception. A higher dose rate of 12 micrograms/kg also failed to produce antinociception to a mechanical stimulus. In addition, the effect of the drug (6 micrograms/kg) on respiratory gas tensions was determined and no significant changes were observed.
Waterman
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AE
Department of Veterinary Surgery, University of Bristol, UK.
Livingston
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A
Amin
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A
D000698:Analgesia / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis; D002047:Buprenorphine / Q000008:administration & dosage / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous / Q000662:veterinary; D009619:Nociceptors / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects*; D012684:Sensory Thresholds; D012756:Sheep / Q000502:physiology*
D001639:Bicarbonates; D002245:Carbon Dioxide; D002047:Buprenorphine; D010100:Oxygen