Bleeding diathesis coincident with chronic myelomonocytic leukaemia.
Two important haematological problems were found in an otherwise healthy 78 year old man: chronic myelomonocytic leukaemia; and a complex, acquired, hyperfibrinolytic bleeding disorder characterized by prolonged coagulation times, deficiency of coagulation factors V, X, and XI, anti-thrombin III and proteins C and S, with high concentrations of circulating tissue plasminogen activator, and low concentrations of plasminogen activator inhibitor. There may be a causal relation between the two conditions, with the peripheral blood monocytes mediating the hyperfibrinolytic process by the abnormal production of tissue plasminogen activator, though no previous description of a similar association has been reported.
Heard
S E
SE
Supra-Regional Haemophilia Centre, St Thomas's Hospital, London.
Revell
P
P
Holland
L J
LJ
Hurdle
A D
AD
Savidge
G F
GF
D000368:Aged; D001780:Blood Coagulation Tests; D001803:Blood Transfusion; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D006474:Hemorrhagic Disorders / Q000209:etiology* / Q000628:therapy; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000097:blood / Q000150:complications*; D008297:Male
D003894:Deamino Arginine Vasopressin