Analysis of B10.D2 recombinant congenic mouse strains shows that audiogenic and beta-CCM-induced seizures depend on different genetic mechanisms.
The rate of occurrence of audiogenic seizures and seizures induced by the benzodiazepine receptor inverse agonist methyl-beta-carboline-3-carboxylate (beta-CCM) were analyzed in several recombinant congenic strains of mice bred from B10.D2 and DBA/2J. Although both types of seizures have similar behavioral patterns and might involve GABAergic mechanisms, no correlation was observed between the occurrence of the two types of seizures across the strains, suggesting that these two types of seizures depend on different genetic mechanisms.
Martin
B
B
CNRS, UFR Biomédicale Paris, France.
Chapouthier
G
G
Motta
R
R
D000161:Acoustic Stimulation; D000818:Animals; D002243:Carbolines / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D007178:Inbreeding; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D012640:Seizures / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology
D002243:Carbolines; C026072:1-methyl-beta-carboline-3-carboxylic acid