[Use of chloral hydrate for assessing the detoxifying function of the liver in experimental pathology].
A new procedure, developed for evaluation of the liver tissue detoxicating activity in experimental pathology, involved estimation of chloral hydrate pharmacological efficiency and registration of animal sleep duration. As activity of uridine phosphate glucuronyl transferase, the key enzyme of the second step of biotransformation, was found to be inhibited after thermic burns, treatment of the disease using phenobarbital appears to correct the enzymatic activity.
Riabinin
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Lifshits
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D000818:Animals; D002056:Burns / Q000378:metabolism*; D002697:Chloral Hydrate / Q000494:pharmacology*; D005965:Glucuronates / Q000378:metabolism; D020723:Glucuronic Acid; D014453:Glucuronosyltransferase / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008862:Microsomes, Liver / Q000201:enzymology / Q000502:physiology*
D005965:Glucuronates; D002697:Chloral Hydrate; D020723:Glucuronic Acid; D014453:Glucuronosyltransferase
Ispol'zovanie khloral gidrata dlia otsenki detoksitsiruiushcheĭ funktsii pecheni pri éksperimental'noĭ patologii.