title: The DNA-activated protein kinase, DNA-PK: a potential coordinator of nuclear events.
abstract: DNA-PK is a moderately abundant serine/threonine protein kinase found in the nucleus of a wide range of eukaryotic cells. It is one of the few known cellular enzymes whose activity is regulated directly by DNA. Many DNA binding proteins, including a number of transcription factors, are substrates for DNA-PK in vitro. We suggest that this kinase may coordinate signal transduction pathways and nuclear events, including transcription, in response to changes in DNA or chromatin state.
authors.affiliation: Biology Department, Brookhaven National Laboratory, Upton, New York 11973.
authors.forename: S P
authors.initials: SP
authors.lastname: Lees-Miller
authors.forename: C W
authors.initials: CW
authors.lastname: Anderson
mesh_terms: D000595:Amino Acid Sequence; D002467:Cell Nucleus / Q000201:enzymology*; D004247:DNA / Q000502:physiology*; D004789:Enzyme Activation / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000737:chemistry / Q000502:physiology*; D013379:Substrate Specificity
chemical_list: D004247:DNA; D011494:Protein Kinases