Gingival hyperplasia induced by nifedipine.
We describe 4 cases of gingival hyperplasia induced by nifedipine, together with clinical and histological findings. Hyperplasia of the interdental papillae was observed in all cases. Histologic examination showed multilayered epithelial parakeratosis with variations in the width, proliferation, reticulation and elongation of the rete pegs. Substitution of another drug and improvement of oral hygiene led to reduction of the gingival overgrowth without gingivectomy. These treatments are essential for gingival hyperplasia induced by nifedipine.
Akimoto
Y
Y
Second Department of Oral Surgery, Nihon University school of Dentistry, Matsudo, Japan.
Tanaka
S
S
Omata
H
H
Shibutani
J
J
Nakano
Y
Y
Kaneko
K
K
Kawana
T
T
Teshigawara
H
H
Nakao
S
S
Fujii
A
A
D000368:Aged; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects*
D009543:Nifedipine