title: Thrombosis-inducing activity in plasma of patients with acute respiratory tract infection disappears after treatment.
abstract: Thrombosis-inducing activity (TIA) was identified in plasma from 16 of 27 patients (59%) with acute respiratory tract infections. On the other hand, it was present in only 9 of 79 subjects (11%) with chronic lung diseases and 4 of 49 healthy volunteers (8%). In the patients with acute respiratory tract infections, there were significant elevations in plasma fibrinogen, C-reactive protein and erythrocyte sedimentation rate in the TIA-positive group compared with the negative group. Plasma TIA disappeared in all of the 8 patients who were retested for TIA 2-5 weeks after they became disease free. Pneumonia was induced in rabbits by transbronchial injection of viable Escherichia coli. TIA was not present in plasma from normal rabbits, but it appeared in plasma collected 3 days after injection. It then disappeared after 1-2 weeks of treatment with antibiotics. TIA may serve as a marker for inflammatory responses and be a factor responsible for elevated blood coagulation activity in patients with acute infectious diseases.
authors.affiliation: Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ogata
authors.forename: K
authors.initials: K
authors.lastname: Yagawa
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
authors.forename: H
authors.initials: H
authors.lastname: Ogino
authors.forename: Y
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ichinose
authors.forename: T
authors.initials: T
authors.lastname: Koga
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001681:Biological Assay; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D015296:Ceftizoxime / Q000627:therapeutic use; D004927:Escherichia coli Infections / Q000097:blood / Q000188:drug therapy; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D011014:Pneumonia / Q000097:blood / Q000188:drug therapy; D011817:Rabbits; D012141:Respiratory Tract Infections / Q000097:blood* / Q000188:drug therapy; D013927:Thrombosis / Q000097:blood*
chemical_list: D005340:Fibrinogen; D002097:C-Reactive Protein; D015296:Ceftizoxime