title: Use of the hormonal response to clomiphene citrate as an endocrinological indicator of ovarian ageing.
abstract: We compared the gonadotrophin and oestradiol responses to clomiphene citrate (CC) in women aged 18-25 versus 35-40 years. Despite similar baseline hormone concentrations and the attainment of similar concentrations of the E and Z isomers of clomiphene, higher follicle stimulating hormone (FSH) concentrations were observed in the older women, possibly indicative of their ageing ovaries. Furthermore, diminished oestradiol responses occurred in a subgroup of women showing FSH hyper-responsiveness to CC. These preliminary results support the concept that the hormonal response to CC may be an indicator of approaching perimenopause.
authors.affiliation: Department of Obstetrics, Gynecology University of Texas Medical School, Houston 77030.
authors.forename: S
authors.initials: S
authors.lastname: Nader
authors.forename: A S
authors.initials: AS
authors.lastname: Berkowitz
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000097:blood*; D002996:Clomiphene; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D005500:Follow-Up Studies; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D010053:Ovary / Q000502:physiology*; D011446:Prospective Studies
chemical_list: D002996:Clomiphene; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone