Continuous removal of anti-DNA antibody, using a new extracorporeal immunoadsorption system, in patients with systemic lupus erythematosus.
We performed selective and continuous immunoadsorption of anti-DNA antibodies from the blood of 6 patients with systemic lupus erythematosus, using a newly developed extracorporeal immunoadsorption system equipped with twin dextran sulfate-cellulose columns with an automated regenerating unit. Levels of anti-DNA, which were initially high, were rapidly diminished after 2-4 apheresis procedures in each patient; in 3 patients with proteinuria and 4 patients with lymphocytopenia, these symptoms also improved. Analysis of the kinetics and the adsorbed amounts of anti-DNA during the apheresis indicates that both the intravascular and the extravascular pool of anti-DNA are reduced with this potent apheresis technique.
Suzuki
K
K
Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Hara
M
M
Harigai
M
M
Ishizuka
T
T
Hirose
T
T
Matsuki
Y
Y
Kawaguchi
Y
Y
Kitani
A
A
Kawagoe
M
M
Nakamura
H
H
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D001781:Blood Component Removal; D002480:Cellulase; D016264:Dextran Sulfate; D005260:Female; D006801:Humans; D007163:Immunosorbent Techniques; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000974:Antibodies, Antinuclear; D016264:Dextran Sulfate; D002480:Cellulase