Effects of two cations on gastrointestinal absorption of ofloxacin.
A study was performed to establish the effect of Al3+ and Fe2+ cations on the absorption of ofloxacin when it is administered orally at a dose of 200 mg. The study was carried out with nine volunteers, who each received three treatments (A [200 mg of ofloxacin], B [200 mg of ofloxacin plus 11 g of colloidal aluminum phosphate], and C [200 mg of ofloxacin plus 1,050 mg of FeSO4]) according to a Latin square design; the washout period was 1 week. The analytical technique was a microbiological diffusion method. The pharmacokinetic parameters were calculated from the cumulative urinary excretion data and from a sigma-minus plot. The total amount of ofloxacin excreted in urine had a mean value of 163.59 +/- 22.13 mg when ofloxacin was administered alone, 152.41 +/- 18.76 mg when it was administered with Al3+, and 146.49 +/- 14.85 mg when it was administered with Fe2+. No statistically significant differences were found in the F values (fractions of dose absorbed) obtained with ofloxacin alone and ofloxacin plus Al3+ (P = 0.341). When ofloxacin alone was compared with joint administration with Fe2+ the value of F decreased 10.85%; this difference is statistically significant (P = 2.623 x 10(-2)).
Martínez Cabarga
M
M
Department of Pharmacy and Pharmaceutical Technology, University of Salamanca, Spain.
Sánchez Navarro
A
A
Colino Gandarillas
C I
CI
Domínguez-Gil
A
A
D000328:Adult; D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000494:pharmacology*; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics*; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis
D015242:Ofloxacin; D000535:Aluminum; D007501:Iron