Discordant xenografting: challenges and controversies.
The transplantation of organs between individuals of disparate species is being considered as a potential solution to a serious shortage of donor organs for clinical transplantation. We summarize recent papers concerning the immunologic barrier to xenotransplantation, the pathogenesis of hyperacute rejection and reports on efforts made to prevent or mitigate hyperacute xenograft rejection.
Platt
J L
JL
University of Minnesota, Minneapolis.
Bach
F H
FH
D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology; D006084:Graft Rejection; D006801:Humans; D007165:Immunosuppression Therapy; D008253:Macaca mulatta / Q000276:immunology; D013552:Swine / Q000276:immunology; D014183:Transplantation, Heterologous / Q000276:immunology
D000910:Antibodies, Heterophile; D003165:Complement System Proteins