Excitability changes in C fibers of rat sciatic nerve following impulse activity.
Three phases in the oscillatory changes of both threshold and conduction velocity were identified following impulse activity in single C fibers of rat sciatic nerves. These after-oscillations, occurring after the refractory period, varied with the number and timing of preceding 'conditioning' impulses. The excitability changes differed both qualitatively and quantitatively among fibers, thus implying underlying variation among C fibers in the density and distribution of voltage-gated channels and ion pumps.
Shin
H C
HC
Anesthesia Research Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Raymond
S A
SA
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D051381:Rats; D012032:Refractory Period, Electrophysiological / Q000502:physiology; D012584:Sciatic Nerve / Q000166:cytology* / Q000502:physiology