Effect of drugs on a noninvasive index of arterial compliance in healthy and heart failure patients.
Ten healthy (aged 28 to 39) and ten heart failure NYHA II (aged 19 to 49) male subjects were prospectively studied under no drugs, under furosemide (40 mg/day), under captopril (150 mg/day) and under their association. Arterial compliance (ml/mmHg) was measured in all subjects at rest and supine. Heart failure etiology was dilated cardiomyopathy or ischemic heart disease without significant regurgitation. Arterial compliance was significantly higher in healthy than in heart failure patients in all studied conditions (p less than 0.001) (healthy = 2.2 + 0.29 vs. heart failure = 0.79 + 0.14). Neither single drug nor their association induced any change in healthy subjects. Arterial compliance progressively increased in heart failure with furosemide, captopril, and their association (no drug = 0.79 + 0.14; furosemide = 0.87 + 0.15; captopril = 0.94 + 0.15 and furosemide + captopril = 0.99 + 0.14). Captopril induced a higher increment than furosemide (p less than 0.001) and their association even a higher increment (p less than 0.001) than any single drug. Thus captopril and/or furosemide increased arterial compliance in heart failure but not in healthy subjects, possibly through changes in arterial wall edema and smooth muscle contraction.
Domingo
E
E
Cardiology Division, Hospital Universitari Vall Hebron, Barcelona, Spain.
Gilabert
M R
MR
Alio
J
J
Angel
J
J
Soler-Soler
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002216:Captopril / Q000008:administration & dosage*; D002307:Cardiography, Impedance; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage*; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects* / Q000502:physiology*
D005665:Furosemide; D002216:Captopril