title: Relationship between bladder dysfunction and brain MRI in multiple sclerosis.
abstract: We studied 70 consecutive patients with definite multiple sclerosis (MS) to examine the relationship between magnetic resonance imaging (MRI) cerebral findings and urinary disturbances. Thirty-two subjects (46%) had urinary symptoms and 38 (54%) were asymptomatic. Patients with urinary symptoms exhibited greater overall functional disability. A significant correlation between the presence of midbrain lesions and urinary dysfunctions was found which may indicate an important role of the mesencephalic formation to preserve continence.
authors.affiliation: Department of Neurological Sciences, La Sapienza University, Rome, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Grasso
authors.forename: C
authors.initials: C
authors.lastname: Pozzilli
authors.forename: A
authors.initials: A
authors.lastname: Anzini
authors.forename: M
authors.initials: M
authors.lastname: Salvetti
authors.forename: S
authors.initials: S
authors.lastname: Bastianello
authors.forename: C
authors.initials: C
authors.lastname: Fieschi
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D008875:Middle Aged; D009186:Myelin Sheath / Q000473:pathology; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D011446:Prospective Studies; D001743:Urinary Bladder / Q000294:innervation; D001750:Urinary Bladder, Neurogenic / Q000175:diagnosis* / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology