Gamete intrafallopian transfer (GIFT) compared with intrauterine insemination in the treatment of unexplained infertility.
OBJECTIVE
To compare GIFT, intrauterine insemination (IUI) with, and without, ovarian hyperstimulation in the treatment of unexplained infertility.


METHODS
Women randomly allocated to one of three treatment protocols.


METHODS
Northern Regional Fertility Centre.


METHODS
59 couples with unexplained infertility of more than 3 years duration.


METHODS
Three cycles of either GIFT, IUI after ovarian hyperstimulation or IUI in a spontaneous cycle.


METHODS
Pregnancy resulting in a live birth.


RESULTS
Fecundabilities were 0.12 after GIFT, 0.018 after ovarian hyperstimulation and IUI, and 0.018 after IUI in a spontaneous cycle. The fecundability after IUI was no different from that which would be expected without treatment in these couples but fecundability was significantly better (P greater than 0.02) after GIFT.


CONCLUSIONS
This trial does not support the use of IUI in the treatment of unexplained infertility but confirms the value of GIFT.
Murdoch
A P
AP
Department of Obstetrics and Gynaecology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Harris
M
M
Mahroo
M
M
Williams
M
M
Dunlop
W
W
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D005260:Female; D005298:Fertility; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008596:Menotropins / Q000008:administration & dosage; D006080:Ovarian Follicle / Q000187:drug effects; D010062:Ovulation Induction; D011247:Pregnancy
D006063:Chorionic Gonadotropin; D008596:Menotropins