title: A 1H-NMR study of the solution conformation of cyclo(GRGDSPA): conformational effects on the physiological activity.
abstract: Solution conformations of cyclo(GRGDSPA) have been analyzed by the use of two-dimensional proton nuclear magnetic resonance spectroscopy and the dynamical simulated annealing calculation. It has been shown that the RGDS segment in cyclo(GRGDSPA) takes a beta-turn conformation. We have concluded that this beta-turn conformation is essential for the physiological activity of cyclo(GRGDSPA).
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Mizutani
authors.forename: I
authors.initials: I
authors.lastname: Shimada
authors.forename: Y
authors.initials: Y
authors.lastname: Ueno
authors.forename: M
authors.initials: M
authors.lastname: Yoda
authors.forename: H
authors.initials: H
authors.lastname: Kumagai
authors.forename: Y
authors.initials: Y
authors.lastname: Arata
mesh_terms: D000595:Amino Acid Sequence; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology; D011487:Protein Conformation; D013329:Structure-Activity Relationship
chemical_list: D010456:Peptides, Cyclic; C068733:cyclo(glycyl-arginyl-glycyl-aspartyl-seryl-aspartyl-alanyl); D006859:Hydrogen