title: Clinical evaluation of a scintigraphic method for diagnosing inflammations/infections using indium-111-labeled nonspecific human IgG.
abstract: This study was undertaken as part of a Phase II study to assess the sensitivity and safety of 111In-DTPA-human IgG, an imaging agent for the detection of inflammations and/or infections. Forty patients with infection/inflammation on the basis of clinical findings, microbiologic results, and/or the basis of results from other imaging modalities were studied. For evaluation of sensitivity, whole-body images were obtained at 6-12 hr (early) and 20-28 hr (delayed) postinjection and occasionally at 48 hr. No adverse reactions were recorded in any of the 40 patients studied. Positive results were obtained in 37 of 37 evaluable subjects (100%). The test appears to be a promising method for the detection of inflammation and/or infection.
authors.affiliation: University of Miami/Jackson Memorial Medical Center, Florida.
authors.forename: A N
authors.initials: AN
authors.lastname: Serafini
authors.forename: I
authors.initials: I
authors.lastname: Garty
authors.forename: R
authors.initials: R
authors.lastname: Vargas-Cuba
authors.forename: A
authors.initials: A
authors.lastname: Friedman
authors.forename: D A
authors.initials: DA
authors.lastname: Rauh
authors.forename: M
authors.initials: M
authors.lastname: Neptune
authors.forename: L
authors.initials: L
authors.lastname: Landress
authors.forename: G N
authors.initials: GN
authors.lastname: Sfakianakis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects; D007239:Infections / Q000000981:diagnostic imaging*; D007249:Inflammation / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
chemical_list: C069971:DTPA-IgG complex; D007074:Immunoglobulin G; D004369:Pentetic Acid