title: Documentation of successful treatment of prosthetic mitral valve thrombosis with intravenous urokinase infusion for twenty-four hours.
abstract: Prosthetic valve thrombosis is a life-threatening situation requiring prompt diagnosis and treatment. Treatment has usually been surgical and has been associated with a high mortality. Thrombolytic therapy is a therapeutic alternative to surgery and has been successful in a number of cases. This report concerns the technique used to diagnose the condition, treatment strategy, and documentation of the results of therapy.
authors.affiliation: Department of Medicine, University of Florida, Gainesville.
authors.forename: H J
authors.initials: HJ
authors.lastname: Chen
authors.forename: J D
authors.initials: JD
authors.lastname: Schlaifer
authors.forename: S M
authors.initials: SM
authors.lastname: Guentzel
authors.forename: C R
authors.initials: CR
authors.lastname: Conti
mesh_terms: D000328:Adult; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D008943:Mitral Valve; D013300:Streptokinase / Q000009:adverse effects; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator