[Assessment of the genotoxicity of the "Binase" enzyme preparation].
"Binase" enzyme sample (a microbial ribonuclease) has been tested for mutagenicity in a set of tests. The set included Ames test Salmonella/microsome, Escherichia coli Rec-test, bacteriophage induction assay, DNA-repair synthesis in lymphoid cells. "Binase" is shown to possess a small genotoxic effect at high concentrations. Both animal and plant S-9 fractions eliminated the effect.
Ivanchenko
O B
OB
Il'inskaia
O N
ON
Karamova
N S
NS
Cherepneva
I E
IE
D000818:Animals; D001711:Biotransformation; D002645:Chickens; D004722:Endoribonucleases / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D010944:Plants / Q000187:drug effects; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics
D004722:Endoribonucleases; C022543:ribonuclease T(2)
Otsenka genotoksichenosi fermentnogo preparata "Binaza".