[The dynamics of the concentrations of immunoglobulins and circulating immune complexes during low-density lipoprotein apheresis in patients with hereditary hypercholesterolemia].
Sessions of-low density lipoproteins (LDL) apheresis using sorbents with mono- and polyclonal antibodies possessing the most selective and specific effect with respect to LDL provoked a less marked decrease of the concentrations of immunoglobulins and circulating immune complexes. This attests to their high selectivity and specificity. Sorbents with dextran sulfate and heparin sepharose exerted a more evident influence on the concentrations of these serum components. However, that was not accompanied by any clinical manifestations of immune deficiency. The use of plasmapheresis brought about a more pronounced lowering of the concentrations of the serum components under study.
Bokchubaev
E T
ET
Konovalov
G A
GA
Nasonov
E L
EL
Kukharchuk
V V
VV
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000628:therapy*; D007136:Immunoglobulins / Q000097:blood*; D007163:Immunosorbent Techniques; D008077:Lipoproteins, LDL / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D008077:Lipoproteins, LDL
Dinamika kontsentratsiĭ immunoglobulinov i tsirkuliruiushchikh immunnykh kompleksov v protsesse afereza lipoproteidov nizkoĭ plotnosti u bol'nykh nasledstvennoĭ giperkholesterinemieĭ.