title: Meningococcal infection: evidence for school transmission.
abstract: Intimate contacts of a patient with meningococcal disease are at greater risk of disease than the general population and are offered chemoprophylaxis in order to prevent secondary cases. School contact is not considered a risk factor unless a further case develops. Bacteriological sampling of contacts to identify potential sources of infection is not considered warranted. We have questioned these approaches and investigated the contacts of a 9-year-old child with meningitis caused by sulphonamide-sensitive Neisseria meningitidis group C. Household carriers were not identified but 7/34 classmates were carrying the index strain suggesting that transmission was occurring within this population. The current recommendations for prophylaxis are based on information gathered in socioepidemiological settings, and involving strains which differ from those now prevalent. Such extrapolations may not be justified and further microbiological studies seem warranted to re-examine meningococcal transmission and prophylaxis usage in school children.
authors.affiliation: Department of Microbiology, Northwick Park Hospital, Middlesex, U.K.
authors.forename: R
authors.initials: R
authors.lastname: Wall
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: B
authors.initials: B
authors.lastname: MacArdle
authors.forename: Z
authors.initials: Z
authors.lastname: Vellani
mesh_terms: D002353:Carrier State / Q000382:microbiology; D002648:Child; D016358:Contact Tracing; D004196:Disease Outbreaks / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007841:Latex Fixation Tests; D008585:Meningitis, Meningococcal / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission*; D009345:Neisseria meningitidis / Q000302:isolation & purification*; D009960:Oropharynx / Q000382:microbiology; D012293:Rifampin / Q000627:therapeutic use; D012307:Risk Factors; D012574:Schools; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D012293:Rifampin