Intrathecal baclofen. Effects on nocturnal leg muscle spasticity.
Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design. Tibialis anterior electromyographic activity per hour of sleep was reduced on the night of baclofen infusion. In particular, less electromyographic activity occurred after arousal from sleep.
Kravitz
H M
HM
Department of Psychiatry, Rush-Presbyterian-Saint Luke's Medical Center, College of Kinesiology, University of Illinois, Chicago 60680.
Corcos
D M
DM
Hansen
G
G
Penn
R D
RD
Cartwright
R D
RD
Gianino
J
J
D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D004311:Double-Blind Method; D004576:Electromyography; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D013119:Spinal Cord Injuries / Q000150:complications*
D001418:Baclofen