title: [Copper metabolism in scleral tissue and possibilities of its correction in myopia].
abstract: Copper measurements in scleral tissue of 14 cadaveric emmetropic eyes and in 10 eyes with myopia of various degrees have shown a significant reduction of these levels in the equatorial and posterior segments of myopic sclera and abnormal distribution of copper in the tissue, this indicating disordered metabolism of this trace element. A method for drug correction of the detected disorder has been experimentally tried, consisting in administration under the Tenon's capsule of a copper coordination compound on a foam composition base, used for sclera-fortifying injections in progressive myopia. This resulted in elevation of scleral copper concentration, activization of collagen biosynthesis processes, and improvement of scleral tissue elasticity.
authors.forename: E S
authors.initials: ES
authors.lastname: Avetisov
authors.forename: M I
authors.initials: MI
authors.lastname: Vinetskaia
authors.forename: E N
authors.initials: EN
authors.lastname: Iomdina
authors.forename: F R
authors.initials: FR
authors.lastname: Makhmudova
authors.forename: Z K
authors.initials: ZK
authors.lastname: Boltaeva
authors.forename: E P
authors.initials: EP
authors.lastname: Tarutta
mesh_terms: D000328:Adult; D002102:Cadaver; D003094:Collagen / Q000096:biosynthesis; D003300:Copper / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009216:Myopia / Q000188:drug therapy / Q000378:metabolism*; D012590:Sclera / Q000378:metabolism*
chemical_list: D003300:Copper; D003094:Collagen
vernacular_title: Obmen medi v skleral'noĭ tkani i vozmozhnosti ego korrektsii pri myopii.