title: [Laboratory and clinical studies on cefdinir (10% fine granules) in pediatric field].
abstract: Clinical studies on 10% fine granules of cefdinir (CFDN), a new cephem antibiotic, were carried out in the field of pediatrics. The results obtained are summarized as follows. 1. Half-lives of CFDN in plasma in 3 children when administered on an empty stomach were 1.77 hours (3 mg/kg per os) and 1.47 hours (6 mg/kg per os), respectively. Eight hour urinary excretion rates of CFDN were 21.5% (3 mg/kg per os) and 16.4% (6 mg/kg per os), respectively. 2. CFDN was administered to 11 children with various bacterial infections: 1 patient with scarlet fever, 1 with pharyngotonsillitis, 3 with acute bronchitis, 3 with pneumonia and 3 with urinary tract infections. The overall clinical efficacy rate was 90.9%. 3. Loose stool was noted in 1 patient. No abnormal laboratory test values were encountered.
authors.affiliation: Department of Pediatrics, Anjo Kosei Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Kuno
authors.forename: A
authors.initials: A
authors.lastname: Ogawa
authors.forename: H
authors.initials: H
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Tomita
authors.forename: O
authors.initials: O
authors.lastname: Kitoh
authors.forename: H
authors.initials: H
authors.lastname: Andoh
authors.forename: Y
authors.initials: Y
authors.lastname: Takimoto
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D000077525:Cefdinir; D002511:Cephalosporins / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004304:Dosage Forms; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D002511:Cephalosporins; D004304:Dosage Forms; D000077525:Cefdinir