Acceleration of wound healing by local application of fibronectin.
The process of wound healing under the influence of locally applied fibronectin, heparin and thrombin was studied in adult rabbits. Using immunofluorescence microscopy, a higher concentration of fibronectin within the wound area was found on the 1st day after fibronectin treatment. The tensile strength of the wounds was tested on the 6th, 9th and 12th day after operation. On the 9th day the tensile strength of the fibronectin-treated wounds was significantly higher than that of the control wounds on the 12th day after operation. The addition of heparin and thrombin, each in combination with fibronectin, did not show any significant effect on wound healing.
Scheel
G
G
Orthopedic Department, Medical Academy Erfurt, Federal Republic of Germany.
Rahfoth
B
B
Franke
J
J
Grau
P
P
D000818:Animals; D004359:Drug Therapy, Combination; D005353:Fibronectins / Q000008:administration & dosage / Q000494:pharmacology*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits; D013718:Tensile Strength / Q000187:drug effects; D013917:Thrombin / Q000008:administration & dosage / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000503:physiopathology*
D005353:Fibronectins; D006493:Heparin; D013917:Thrombin