Hydrogen bonds involving sulfur atoms in proteins.
Intrachain hydrogen bonds are a hallmark of globular proteins. Traditionally, these involve oxygen and nitrogen atoms. The electronic structure of sulfur is compatible with hydrogen bond formation as well. We surveyed a set of 85 high-resolution protein structures in order to evaluate the prevalence and geometry of sulfur-containing hydrogen bonds. This information should be of interest to experimentalists and theoreticians interested in protein structure and protein engineering.
Gregoret
L M
LM
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446.
Rader
S D
SD
Fletterick
R J
RJ
Cohen
F E
FE
D000818:Animals; D003545:Cysteine / Q000737:chemistry; D006860:Hydrogen Bonding; D008715:Methionine / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D014961:X-Ray Diffraction
D011506:Proteins; D013455:Sulfur; D008715:Methionine; D003545:Cysteine