Interaction between thiopentone and subhypnotic doses of ketamine.
The hypnotic effects of thiopentone and ketamine were studied in ASA Grade I female patients aged 20-30 without premedication. The dose-response curves of ketamine 0.4 mg kg-1 and thiopentone following ketamine 0.4 mg kg-1 were determined by probit analysis. The interaction between ketamine and thiopentone was found to be an antagonistic one. This effect can be interpreted as a consequence of the different neurophysiological spectra of action of the two drugs.
Manani
G
G
Institute of Anesthesiology and Intensive Care, University of Padua, Italy.
Valenti
S
S
Vincenti
E
E
Segatto
A
A
Zanette
G
G
Giron
G P
GP
Galzigna
L
L
D000328:Adult; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage*; D013514:Surgical Procedures, Operative; D013874:Thiopental / Q000008:administration & dosage*
D007649:Ketamine; D013874:Thiopental