[Visually evoked cortical potentials for early detection of optic neuritis in ethambutol therapy].
Ethambutol leads to chronic, severe optic neuritis with sudden onset in approximately 5-14% of all patients. Therefore, the ability of visually (pattern) evoked potentials for the early diagnosis of ethambutol-induced optic neuritis was tested. During ethambutol therapy prolonged latency was documented in 5 of 15 cases (33%). One of these 5 cases showed a reversible decrease in visual acuity. Thus, during treatment with ethambutol visually (pattern) evoked potentials may reveal a surprisingly high percentage of subclinical optic neuritis. These patients need close supervision in order to facilitate early discontinuation of the drug when neuritis develops.
Dette
T M
TM
Universitäts-Augenklinik, Bonn, Bundesrepublik Deutschland.
Spitznas
M
M
Göbbels
M
M
Koch
F
F
Leinhos
C
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004977:Ethambutol / Q000008:administration & dosage / Q000009:adverse effects*; D005074:Evoked Potentials, Visual / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000139:chemically induced* / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014793:Visual Cortex / Q000187:drug effects / Q000503:physiopathology
D004977:Ethambutol
Visuell evozierte kortikale Potentiale zur Früherkennung der Neuritis nervi optici unter Ethambutoltherapie.