title: Enzymatic peptide synthesis in organic solvent mediated by gels of copolymerized acrylic derivatives of alpha-chymotrypsin and polyoxyethylene.
abstract: Copolymers of acrylated derivatives of alpha-chymotrypsin and polyethylene glycol (PEG) have been prepared and used as biocatalysts for the synthesis of model peptides in organic solvent containing a low quantity of water. Other peptide couplings have been tried to point out the chemico- and stereoselectivity and examples of segment couplings are given.
authors.affiliation: Laboratory for the Synthesis and Physiochemical Studies of Amino Acids and Peptides, URA 468, University of Montpellier II, France.
authors.forename: V
authors.initials: V
authors.lastname: Fulcrand
authors.forename: R
authors.initials: R
authors.lastname: Jacquier
authors.forename: R
authors.initials: R
authors.lastname: Lazaro
authors.forename: P
authors.initials: P
authors.lastname: Viallefont
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000215:Acylation; D002384:Catalysis; D002918:Chymotrypsin / Q000737:chemistry*; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000179:Acrylates; D010455:Peptides; D011108:Polymers; D011092:Polyethylene Glycols; C026200:acryloyl chloride; D002918:Chymotrypsin