[Perioperative antibiotic prophylaxis in reconstruction of the thoracic wall].
Thirty youngs and children were submitted to surgical reconstruction of excavated chest. To prevent risk of infections (by Staphylococcus and mixed gram-negative flora) preoperative 100 mg/Kg body weight of cefotaxime was given. In all patients the operative wounds healed regularly. To evaluate cefotaxime level and that of its metabolites raised in the tissues, the very sensibles method HPLC was applied. Thus 45 minutes after antibiotic somministration, very high levels were present in cartilage 9.8 mmg/gr and in bones (9.3 mmg/gr). Related to Staphylococcus aureus (MHK 90 of about 2 mmg/ml) results are of value also for other surgical orthopedic operations.
Rupprecht
H
H
Univ. Klinik Erlangen.
Hummer
H P
HP
Kees
F
F
D000293:Adolescent; D000328:Adult; D002439:Cefotaxime / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D005660:Funnel Chest / Q000601:surgery; D016905:Gram-Negative Bacterial Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D011292:Premedication; D013203:Staphylococcal Infections / Q000517:prevention & control*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013903:Thoracic Surgery / Q000379:methods*; D013909:Thorax / Q000002:abnormalities
D002439:Cefotaxime
Profilassi antibiotica perioperatoria nella ricostruzione della parete toracica.