[Morphologic manifestations of the preclinical stage of diabetic nephropathy].
Kidney biopsies from 10 patients with diagnosed insulin-dependent diabetes mellitus of various duration with clinical manifestations of hyperglycemia, increased rate of glomerular filtration, presence or absence of microalbuminuria, were studied morphologically. Gradual increase of kidney alterations was observed: changes of thickness and loosening of basal membrane of glomerular capillaries, its focal homogenization, partial mesangium increase due to the increase of membranous substance and decrease of cellular component. These alterations positively correlate with immunohistochemistry of renal glomeruli. Dynamics of morphological changes does not show a direct connection with the patient age and the duration of diagnosed disease but is stipulated by the presence of one or another antigen of the class II major histocompatibility complex.
Severgina
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ES
Ponomarev
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AB
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged
Morfologicheskie proiavleniia doklinicheskoĭ stadii diabeticheskoĭ nefropatii.