Pathogenic anti-DNA idiotype (16/6 Id) in systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is regarded as a classical autoimmune disease. Despite this belief, no one has been able to induce the disease in naive animals, neither with DNA nor with anti-DNA antibodies. We report on the induction of SLE in BALB/c mice following immunization with a pathogenic anti-DNA idiotype (16/6 Id) or its anti-Id. We also report on a specific treatment with T suppressor cells specific for the 16/6 Id. The induction of SLE in naive mice with a pathogenic anti-DNA Id suggests an additional mechanism for the diversity of manifestations in this disease.
Shoenfeld
Y
Y
Department of Medicine B, Sheba Medical Center, Tel-Hashomer, Israel.
Mozes
E
E
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology; D004247:DNA / Q000276:immunology*; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology / Q000502:physiology*; D008180:Lupus Erythematosus, Systemic / Q000209:etiology*
D000974:Antibodies, Antinuclear; D012739:Gonadal Steroid Hormones; D007130:Immunoglobulin Idiotypes; D004247:DNA