Thrombin generation in cardiac device recipients.
Thrombin generation measured after LVAS (4 patients) and TAH (1 patient) implantation was found to be elevated (3 times normal) in the first postoperative week and declined to normal levels when anticoagulation was begun. Thrombin generation was not elevated at the times of thromboembolic events (TIAs; N = 4 episodes).
Johnson
P C
PC
Department of Surgery, University of Pittsburgh, Pennsylvania 15261.
Garrett
K O
KO
Borovetz
H L
HL
Kormos
R L
RL
Armitage
J M
JM
Pristas
J M
JM
Pautler
S
S
Griffith
B P
BP
D006354:Heart, Artificial; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D011183:Postoperative Complications / Q000097:blood*; D011474:Prosthesis Design; D011516:Prothrombin / Q000378:metabolism; D011517:Prothrombin Time; D013917:Thrombin / Q000378:metabolism*; D013923:Thromboembolism / Q000097:blood*
D010446:Peptide Fragments; C045879:prothrombin fragment 1.2; D011516:Prothrombin; D013917:Thrombin