Polarized expression of major histocompatibility complex class I molecules in human endometrial and endocervical epithelial cells.
The localization of major histocompatibility complex (MHC) class I molecules in human endometrial and endocervical epithelial cells was studied with an immunogold technique on ultrathin cryosections. At the cell surface, MHC class I molecules are delivered solely to the basolateral plasma membrane in human epithelia. Therefore, only the basolateral domain of epithelial cells is capable of presenting antigen to MHC class I-restricted cytotoxic T cells.
Van Eijkeren
M A
MA
Department of Obstetrics and Gynaecology, University Hospital, Utrecht, The Netherlands.
Peters
P J
PJ
Geuze
H J
HJ
D000328:Adult; D002462:Cell Membrane / Q000276:immunology; D016764:Cell Polarity; D002584:Cervix Uteri / Q000166:cytology / Q000276:immunology*; D004717:Endometrium / Q000166:cytology / Q000276:immunology*; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron
D015395:Histocompatibility Antigens Class I