Interferon-related leukoencephalopathy in a patient with renal cell carcinoma.
A 75-year-old patient with metastatic renal cell carcinoma was treated with recombinant interferon alpha-C and thereafter developed a neurologic syndrome of dementia, ataxia, confusional state, loss of concentration ability and cortical blindness. CT scan findings were compatible with leukoencephalopathy, which is reported as being a toxic effect of interferon.
Merimsky
O
O
Department of Oncology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Israel.
Reider
I
I
Merimsky
E
E
Chaitchik
S
S
D000368:Aged; D001927:Brain Diseases / Q000209:etiology*; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D003711:Demyelinating Diseases / Q000209:etiology*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000628:therapy*; D008297:Male; D011994:Recombinant Proteins
D007370:Interferon Type I; D011994:Recombinant Proteins