X-ray sensitivity of fibroblast cell strains derived from atomic bomb survivors with and without breast cancer.
Fibroblasts were established in vitro from skin biopsies obtained from 55 women and 1 man with or without breast cancer and with or without exposure to radiations from the atomic bomb (A-bomb) explosion in Hiroshima. The radiosensitivity of these cells was evaluated by clonogenic assays after exposure to X-rays. Dose-response curves were fitted to a multitarget model, S/S0 = A[1-(1-e-D/D0)N]. There was no difference in the means or variances of radiosensitivity between exposed and nonexposed groups, or between groups with and without breast cancer.
Ban
S
S
Department of Genetics, Radiation Effects Research Foundation (RERF), Hiroshima, Japan.
Setlow
R B
RB
Ezaki
H
H
Hiraoka
T
T
Yamane
M
M
Nishiki
M
M
Dohi
K
K
D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology*; D002470:Cell Survival / Q000528:radiation effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007564:Japan; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology*; D009689:Nuclear Warfare; D011836:Radiation Tolerance; D013534:Survival