Localization of seizure foci: pitfalls and caveats.
The pitfalls and difficulties in accurately localizing seizure foci are reviewed. Basic issues regarding modeling, volume conduction, inhomogeneities, and corticocortical propagation are discussed, and the limitations of scalp and intracranial recordings are outlined. The ambiguities in interpreting patterns and their significance are highlighted with a concluding commentary on pitfalls in defining the epileptogenic region.
Jayakar
P
P
Comprehensive Epilepsy Center, Miami Children's Hospital, Florida 33155.
Duchowny
M
M
Resnick
T J
TJ
Alvarez
L A
LA
D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000295:instrumentation*; D003198:Computer Simulation; D004569:Electroencephalography / Q000295:instrumentation* / Q000706:statistics & numerical data; D004827:Epilepsy / Q000503:physiopathology; D006801:Humans; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D008962:Models, Theoretical; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*