Measurement of bile acid half-life using [75Se]HCAT in health and intestinal diseases. Comparison with [75Se]HCAT abdominal retention methods.
The diagnostic values in detecting terminal ileum dysfunction using [75Se]HCAT have been assessed for two different scintigraphic techniques in 58 subjects. The measurement of [75Se]HCAT T1/2 in the enterohepatic circulation by daily gallbladder scintigraphy showed 78% sensitivity, 96% specificity, 96% positive predictive value, and 78% negative predictive value at the optimal cutoff level of 2.0 days; lower--but not significantly different--figures were observed for [75Se]HCAT total abdominal retention four and seven days after isotope administration, at the optimal cutoff levels of 40% and 22%, respectively. [75Se]HCAT T1/2 was then evaluated in 60 patients with various intestinal diseases. Sixty-nine percent (9/13) of patients with diarrhea of obscure origin showed abnormal [75Se]HCAT T1/2. Bile acid malabsorption using [75Se]HCAT can be investigated by the noninvasive measurement of its enterohepatic T1/2 and may play a pathogenetic role in patients with diarrhea of obscure origin.
Ferraris
R
R
Department of Gastroenterology and Nuclear Medicine Service, Ospedale Mauriziano Umberto I, Turin, Italy.
Galatola
G
G
Barlotta
A
A
Pellerito
R
R
Fracchia
M
M
Cottino
F
F
de la Pierre
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002763:Cholecystectomy; D003092:Colitis / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000378:metabolism*; D003424:Crohn Disease / Q000378:metabolism*; D003967:Diarrhea / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007079:Ileitis / Q000378:metabolism; D008286:Malabsorption Syndromes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012644:Selenium Radioisotopes / Q000493:pharmacokinetics*; D012680:Sensitivity and Specificity; D013656:Taurocholic Acid / Q000493:pharmacokinetics*
D012644:Selenium Radioisotopes; D013656:Taurocholic Acid