title: Ocular thrombosis associated with antiphospholipid antibodies.
abstract: Four patients with isolated acute ocular ischemic syndromes also had circulating antiphospholipid antibodies. Two patients had vaso-occlusive retinopathy and two, anterior ischemic optic neuropathy (which was successive in one). Extensive clinical laboratory evaluation identified vascular risk factors in two patients. One patient had essential thrombocytosis, confirmed by bone marrow biopsy; the other had stable hypertension and a history of coronary artery disease. These cases suggest that small vessel thrombosis in situ may be a mechanism for antiphospholipid-associated ocular and cerebral ischemia.
authors.affiliation: Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia.
authors.forename: S L
authors.initials: SL
authors.lastname: Galetta
authors.forename: G L
authors.initials: GL
authors.lastname: Plock
authors.forename: M J
authors.initials: MJ
authors.lastname: Kushner
authors.forename: R E
authors.initials: RE
authors.lastname: Wyszynski
authors.forename: A J
authors.initials: AJ
authors.lastname: Brucker
mesh_terms: D000368:Aged; D016736:Antiphospholipid Syndrome / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007511:Ischemia / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000276:immunology; D010743:Phospholipids / Q000276:immunology*; D012171:Retinal Vessels / Q000276:immunology*; D012307:Risk Factors; D013927:Thrombosis / Q000209:etiology* / Q000276:immunology
chemical_list: D001323:Autoantibodies; D010743:Phospholipids