HLA antigens in donovanosis (granuloma inguinale).
OBJECTIVE
To compare the frequencies of HLA antigens in patients with donovanosis and in controls.


METHODS
HLA Class I, Class II and DQ antigens were detected in patients with genital ulceration caused by donovanosis and in a control group.


METHODS
City Health STD Clinic, King Edward VIII Hospital, Durban, South Africa. Participants--Sixty (47 men, 13 women) patients with donovanosis.


RESULTS
HLA B57 was detected in nine of 60 (15%) with donovanosis and 75 of 1478 (5.1%) controls (RR = 3.3 chi 2 = 11.0, p = 0.001, p corrected = 0.026).


CONCLUSIONS
A possible link between donovanosis and HLA B57 could be explained by coexisting alleles or immune response genes in linkage disequilibrium altering disease susceptibility.
O'Farrell
N
N
City Health STD Department, King Edward VIII Hospital, Durban, South Africa.
Hammond
M
M
D004198:Disease Susceptibility; D005260:Female; D006100:Granuloma Inguinale / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D012307:Risk Factors; D013019:South Africa
D006680:HLA Antigens; D015235:HLA-B Antigens