C-band polymorphisms in exotic inbred strains of mice: a method for mapping centromeric ends of chromosomes.
The major satellite DNA of Mus musculus appears as a pericentromeric heterochromatin block in all chromosomes but the Y. While C-banding readily reveals the presence of this heterochromatin block, there is considerable polymorphism in C-band size among the chromosomes and among different subspecies. We have studied the distribution of C-band size differences in the chromosomes of 15 exotic inbred laboratory strains and substrains derived from wild populations of different subspecies of M. musculus. The variation in C-band size among these inbred strains can serve as a useful codominant cytological marker for estimating recombinational distances between the centromere and proximal genes in linkage crosses.
Akeson
E C
EC
Jackson Laboratory, Bar Harbor, ME 04609.
Davisson
M T
MT
D000818:Animals; D002503:Centromere; D002871:Chromosome Banding; D002874:Chromosome Mapping / Q000379:methods*; D004276:DNA, Satellite / Q000235:genetics; D005819:Genetic Markers; D006570:Heterochromatin; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011110:Polymorphism, Genetic
D004276:DNA, Satellite; D005819:Genetic Markers; D006570:Heterochromatin