Large-cell lymphoma presenting with a distinctive inflammatory dermatosis.
Severe, progressively enlarging inflammatory plaques of the upper trunk and neck developed in a 12-year-old girl. Histologic examination revealed a unique inflammatory cell infiltrate that consisted of chronic inflammation in the dermis subtending spongiosis with a diffuse neutrophilic epidermal infiltrate. A tumor in the right axilla was found by computed tomography. Tissue obtained at open biopsy examination demonstrated a large-cell lymphoma of B-cell origin. The tumor and dermatosis responded dramatically to chemotherapy. The distinctive histologic pattern and clinical course suggest that this dermatosis may represent an unusual paraneoplastic presentation of large-cell lymphoma.
Tope
W D
WD
Division of Dermatology, Duke University Medical Center, Durham, NC 27710.
Fishbein
J D
JD
White
P F
PF
Prose
N S
NS
D001365:Axilla; D001706:Biopsy; D002648:Child; D003872:Dermatitis / Q000473:pathology*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010257:Paraneoplastic Syndromes / Q000473:pathology