Metastatic angiosarcoma with thrombocytopenia and intratumoral indium-111-platelet deposition.
A 66-yr-old woman with cutaneous angiosarcoma of the face presented with thrombocytopenia and metastases to the skeleton. Scintigraphic imaging with 111In-oxine-labeled autologous platelets demonstrated localization of radiolabeled platelets at sites of metastatic tumor. This imaging study suggests intratumoral destruction of platelets by the metastases of the malignant vascular tumor as the cause of the patient's thrombocytopenia.
Arcomano
M A
MA
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0229.
Shulkin
B L
BL
Petry
N A
NA
Wahl
R L
RL
D000368:Aged; D001792:Blood Platelets / Q000502:physiology; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D005153:Facial Neoplasms / Q000150:complications* / Q000473:pathology; D005260:Female; D006391:Hemangioma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D006801:Humans; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives*; D011877:Radionuclide Imaging; D013921:Thrombocytopenia / Q000209:etiology*
D009942:Organometallic Compounds; C032950:indium oxine; D015125:Oxyquinoline