Premalignant melanosis of the conjunctiva and the cornea in xeroderma pigmentosum.
Xeroderma pigmentosum is a rare autosomal recessive dermatosis. The neoplastic changes in sunlight-exposed areas of the skin and eyes may be related to the impaired replication of ultraviolet radiation-damaged DNA. A 38-year-old Greek woman is reported with a mild form of xeroderma pigmentosum and primary acquired melanosis with atypia of her right limbal conjunctiva and cornea. The development of this precursor of conjunctival malignant melanoma in a xeroderma pigmentosum patient may support the putative role of sunlight exposure in malignant transformation of conjunctival melanocytes.
Paridaens
A D
AD
Department of Pathology, Institute of Ophthalmology, London.
McCartney
A C
AC
Hungerford
J L
JL
D000328:Adult; D003228:Conjunctiva / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000209:etiology; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000209:etiology*; D005134:Eye Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D008548:Melanosis / Q000209:etiology* / Q000473:pathology; D011230:Precancerous Conditions / Q000209:etiology*; D014983:Xeroderma Pigmentosum / Q000150:complications*