Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation.
Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.
Gordon
B G
BG
Section of Pediatric Hematology/Oncology and Bone Marrow Transplantation, University of Nebraska Medical Center, Omaha 68195-2165.
Saving
K L
KL
McCallister
J A
JA
Warkentin
P I
PI
McConnell
J R
JR
Roberts
W M
WM
Coccia
P F
PF
Haire
W D
WD
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002544:Cerebral Infarction / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000601:surgery; D020151:Protein C Deficiency; D014184:Transplantation, Homologous