title: Induction dose-response of propofol in unpremedicated children.
abstract: The induction dose requirements of propofol were compared in three age groups in 300 unpremedicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2-5 yr (n = 117); group C, 6-12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1.6, 1.8, 2.0, 2.2, 2.4 and 2.6 mg kg-1). ED50 and ED95 for loss of eyelash reflex (LER) and acceptance of face mask (AFM) were determined using probit analysis. ED50 and ED95 for both LER and AFM were greatest in group A, less in B and smallest in C; ED95 (AFM) for groups A, B and C were 2.88 (2.55-3.36), 2.53 (2.31-2.86), and 2.20 (2.02-2.46) mg kg-1, respectively. This probably represented their effective induction dose. The incidence of apnoea was dose related, but not pain on injection.
authors.affiliation: Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories.
authors.forename: C S
authors.initials: CS
authors.lastname: Aun
authors.forename: S M
authors.initials: SM
authors.lastname: Short
authors.forename: D H
authors.initials: DH
authors.lastname: Leung
authors.forename: T E
authors.initials: TE
authors.lastname: Oh
mesh_terms: D000367:Age Factors; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D001049:Apnea / Q000139:chemically induced; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005140:Eyelashes / Q000502:physiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008397:Masks; D010146:Pain / Q000209:etiology; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D012018:Reflex / Q000187:drug effects
chemical_list: D015742:Propofol