title: Amantadine-resistant influenza A in a nursing facility.
abstract: Rapid index case treatment and amantadine prophylaxis were implemented in two nursing homes exposed to influenza A. Facility A had no isolation of cases, and 18 of 22 cases occurred after amantadine hydrochloride therapy was initiated. Three patients exhibited amantadine-resistant virus. Facility B had day 1 isolation of the index case. A facility-wide outbreak did not occur. The experience of these facilities suggests that concurrent amantadine treatment and prophylaxis without adequate case isolation may promote further influenza A infection in a nursing facility.
authors.affiliation: Department of Internal Medicine, St Paul-Ramsey Medical Center, Minn.
authors.forename: J
authors.initials: J
authors.lastname: Degelau
authors.forename: S K
authors.initials: SK
authors.lastname: Somani
authors.forename: S L
authors.initials: SL
authors.lastname: Cooper
authors.forename: D R
authors.initials: DR
authors.lastname: Guay
authors.forename: K B
authors.initials: KB
authors.lastname: Crossley
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000547:Amantadine / Q000627:therapeutic use*; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D009735:Nursing Homes
chemical_list: D000547:Amantadine