Neurotoxic effects of 2,5-hexanedione on growing peripheral nerve axons of rat fetuses.
Peripheral nerves of rat fetuses were used to investigate the potential neurotoxicity of 2,5-hexanedione (2,5-HD) on developing axons. Pregnant female Sprague-Dawley rats were injected subcutaneously with 680 mg/kg of 2,5-HD once a day from day 12 of gestation (GD12) through GD16. On GD20 live fetuses were removed from the uterus, and the sciatic nerves were examined morphologically. Upon electron-microscopy affected nerves showed axons which were aggregated and fused together; the number of large axons was increased, but there were no axons aggregated with neurofilaments.
Ogawa
Y
Y
Department of Hygiene, Jikei University School of Medicine, Tokyo, Japan.
Komatsu
T
T
Fujikake
N
N
Fujii
T
T
Tanaka
J
J
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000473:pathology; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006588:Hexanones / Q000633:toxicity*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology
D006588:Hexanones; C011269:2,5-hexanedione