title: [Synthesis of the tripeptide glycyl-L-leucyl-L-phenylalanine and its analogs].
abstract: Peptide Gly-L-Leu-L-Phe and its derivatives were synthesized by the C-end elongation utilizing DCC/HOBT technique and by enzymatic route with the help of papain using esters of N-benzyloxycarbonyl-glycine and -L-leucine as acyl donors have been suggested. The chemical, similarly to the enzymatic, synthesis was not accompanied by racemization. Conditions for HPLC separation and preparative isolation of the enzymatic reaction products were developed.
authors.forename: O V
authors.initials: OV
authors.lastname: Esipova
authors.forename: S V
authors.initials: SV
authors.lastname: Eremin
authors.forename: E N
authors.initials: EN
authors.lastname: Zvonkova
mesh_terms: D002851:Chromatography, High Pressure Liquid; D009842:Oligopeptides / Q000138:chemical synthesis*; D010206:Papain / Q000737:chemistry
chemical_list: D009842:Oligopeptides; D010206:Papain
vernacular_title: Sintez tripeptida glitsil-L-leĭtsil-L-fenilalanina i ego analogov.