Effect of clentiazem on lipid profile, lipoprotein composition and aortic fatty streaks in cholesterol-fed rabbits.
Numerous experimental studies have reported that common antihypertensive drugs such as diuretics, beta-blockers, and methyldopa have adverse effects on plasma lipids and lipoproteins. The present study was designed to define the effect of clentiazem (10 mg/kg/day) an antihypertensive drug, on hyperlipidemia in rabbits on a cholesterol-rich diet (1%) for 12 weeks. Compared with controls, clentiazem treated rabbits had lower plasma concentrations of triglycerides (55%), total cholesterol (24%), free cholesterol (27%), esterified cholesterol (23%) and phospholipids (24%). The decrease in cholesterol was accounted for by a reduction of VLDL-cholesterol (13%), IDL-cholesterol (24%) and primarily LDL-cholesterol (45%). Neither HDL-cholesterol nor chemical composition of VLDL, IDL, LDL and HDL was altered. When the aortic atherosclerotic involvement was evaluated by computerized planimetry, a 24% reduction of lesions was noted in clentiazem treated animals (P less than 0.05). Similarly, cholesterol content extracted from aortic wall was decreased. Our data therefore demonstrated that clentiazem is a potential antiatherosclerotic agent capable of decreasing plasma lipids and atherogenic lipoproteins as well as aortic fatty streaks.
Levy
E
E
Department of Nutrition, University of Montreal, Québec, Canada.
Tardif
J
J
Russo
P
P
Lavigne
F
F
Thibault
L
L
St-Louis
J
J
Garofalo
C
C
Bendayan
M
M
Bouthillier
D
D
Garceau
D
D
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D001018:Aortic Diseases / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood* / Q000378:metabolism / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004110:Diltiazem / Q000031:analogs & derivatives* / Q000494:pharmacology; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000737:chemistry*; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D000959:Antihypertensive Agents; D002791:Cholesterol, Dietary; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; C056595:clentiazem; D002784:Cholesterol; D004110:Diltiazem