title: Clear cell adenocarcinoma of the vagina: a second primary in a diethylstilbestrol-exposed woman?
abstract: A clear cell adenocarcinoma of the vaginal remnant in a diethylstilbestrol (DES)-exposed woman developed 20 years after anterior exenteration for a histologically similar stage II vaginal cancer. Arguments favoring a new primary cancer over a late recurrence are presented. This case probably represents the first report of a second primary vaginal clear cell cancer after DES exposure in utero. The implications of a second vaginal primary and the need for long-term surveillance in DES-exposed women are discussed.
authors.affiliation: Department of Gynecology, Massachusetts General Hospital, Boston.
authors.forename: A
authors.initials: A
authors.lastname: Goodman
authors.forename: J C
authors.initials: JC
authors.lastname: Sullinger
authors.forename: L W
authors.initials: LW
authors.lastname: Rice
authors.forename: A F
authors.initials: AF
authors.lastname: Fuller
mesh_terms: D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009378:Neoplasms, Multiple Primary; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000473:pathology
chemical_list: D004054:Diethylstilbestrol