Hypoglycemia associated hospitalizations in a population with a high prevalence of non-insulin-dependent diabetes mellitus.
In order to evaluate the rates, causes, and clinical features of hospitalizations associated with hypoglycemia in a population with a high prevalence of non-insulin-dependent diabetes mellitus (NIDDM), a retrospective analysis of medical records was conducted in a multi-hospital primary care system on the Navajo Indian Reservation. During an estimated 26,125 person-years of observation among diabetic patients, there were 126 hypoglycemia-associated admissions related to diabetes among 109 diabetic patients, yielding a hospitalization rate of 4.7 per 1000 person-years (95% CI 4.1-5.7). Using estimates of drug utilization based on a defined daily dose, hospitalization rates were 5.8 per 1000 PY (95% CI 4.4-7.6) for chlorpropamide, 16.0 per 1000 PY (95% CI 9.5-26.9) for glyburide, and 9.1 per 1000 PY (95% CI 6.9-11.9) for insulin. After stratification by age, the relative risk for hypoglycemia-associated hospitalization among patients prescribed glyburide compared to those prescribed chlorpropamide was 2.8 (95% CI 1.6-4.9). Hypoglycemia-associated hospitalizations were relatively common among patients with NIDDM, particularly among those treated with glyburide.
Sugarman
J R
JR
Indian Health Service Epidemiology Program, Seattle, Washington.
D001130:Arizona / Q000453:epidemiology; D002747:Chlorpropamide / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology*; D005905:Glyburide / Q000009:adverse effects*; D006760:Hospitalization; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000453:epidemiology* / Q000401:mortality; D007198:Indians, North American; D007328:Insulin / Q000009:adverse effects*; D009516:New Mexico / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D014589:Utah / Q000453:epidemiology
D007328:Insulin; D005905:Glyburide; D002747:Chlorpropamide