Deficiencies in factors IX and VIII: what is now known.
Genetic defects both gross and subtle have recently been identified in about 900 patients with hemophilia A or B. The defects, which include deletions, insertions, and point mutations, reveal much about genetic structure-function relationships in hemophilia. These insights will lead to improved treatment of bleeding disorders and perhaps to their cure.
Kurachi
K
K
University of Michigan, Ann Arbor.
Yao
S N
SN
Furukawa
M
M
Kurachi
S
S
D001483:Base Sequence; D002869:Chromosome Aberrations; D005164:Factor IX / Q000235:genetics; D005169:Factor VIII / Q000235:genetics; D015316:Genetic Therapy; D006467:Hemophilia A / Q000235:genetics* / Q000628:therapy; D002836:Hemophilia B / Q000235:genetics* / Q000628:therapy; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation
D005169:Factor VIII; D005164:Factor IX