[Phenytoin and phenytoin derivatives for local administration].
A well known side effect of the long-term therapy with phenytoin is gum hyperplasia. 1-Acyl compounds and esters of the p-hydroxymetabolite with aliphatic and aromatic carboxylic acids were synthesized as potential prodrugs for therapeutic use if the neoformation of connective tissue is intended. The compounds were characterized by there physico-chemical constants and the absorption was proofed by a buccal test.
Fürst
W
W
Sektion Pharmazie, Martin-Luther-Universität Halle-Wittenberg.
Wildner
R
R
D000042:Absorption; D000278:Administration, Buccal; D006868:Hydrolysis; D010672:Phenytoin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D011355:Prodrugs / Q000138:chemical synthesis; D012995:Solubility
D011355:Prodrugs; D010672:Phenytoin
Phenytoin und Phenytoinderivate zur lokalen Applikation.