title: Non-ulcer dyspepsia in Nigeria: a case-control study.
abstract: Non-ulcer dyspepsia is common in Africa, yet there are few data on its possible cause. In this study 40 patients with strictly defined non-ulcer dyspepsia were matched with 40 asymptomatic volunteers. Both groups were questioned concerning their intake of alcohol, cola nut, non-steroidal anti-inflammatory drugs, and smoking. They then underwent upper gastrointestinal endoscopy with mucosal biopsy of the gastric mucosa: these biopsies were examined for gastritis and Helicobacter pylori. Ingestion of cola nut was the only statistically significant difference between the two groups. A high prevalence of gastritis and H. pylori infection was found in both groups, suggesting that these factors are not important in the aetiology of non-ulcer dyspepsia in northern Nigeria.
authors.affiliation: Department of Surgery, University of Maiduguri, Nigeria.
authors.forename: C
authors.initials: C
authors.lastname: Holcombe
authors.forename: J
authors.initials: J
authors.lastname: Kaluba
authors.forename: S B
authors.initials: SB
authors.lastname: Lucas
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D004415:Dyspepsia / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D005260:Female; D005756:Gastritis / Q000150:complications; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D009549:Nigeria / Q000453:epidemiology