Exacerbation of Gilles de la Tourette's syndrome associated with thermal stress: a family study.
Gilles de la Tourette's syndrome (TS) is a familial disorder that is often exacerbated by stress or fatigue. Here we present a family of a TS proband that has several members with obsessive-compulsive symptoms, a bleeding disorder, and an unusual sensitivity to heat. The proband, who is affected by all of these traits, was challenged with heat or exercise in climate-controlled conditions and showed a marked increase in the frequency of tics.
Lombroso
P J
PJ
Child Study Center, Yale University, New Haven, CT 06510.
Mack
G
G
Scahill
L
L
King
R A
RA
Leckman
J F
JF
D000293:Adolescent; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010375:Pedigree; D013312:Stress, Physiological / Q000235:genetics / Q000503:physiopathology*; D005879:Tourette Syndrome / Q000235:genetics / Q000503:physiopathology*