title: Urethral T-cell lymphoma as the initial manifestation of the acquired immune deficiency syndrome.
abstract: We report the first case (to our knowledge) of a primary urethral T-cell lymphoma as the initial manifestation of the acquired immune deficiency syndrome. A 36-year-old white homosexual man with antibodies to human immunodeficiency virus type 1 was evaluated for a hemorrhagic urethral discharge. A 2-cm fleshy, polypoid mass in the bulbous urethra was removed, and the diagnosis of small non-cleaved cell (non-Burkitt's) lymphoma was made. Immunohistochemical analysis confirmed that the tumor was of T-cell lineage. Patients with the acquired immunodeficiency syndrome have an increased incidence of lymphomas, particularly extranodal high-grade non-Hodgkin's lymphomas. Primary urethral lymphomas are extremely rare, with only a handful of cases reported in the literature. This rare form and site of lymphoma should be considered in patients with the acquired immunodeficiency syndrome who have genitourinary symptoms.
authors.affiliation: Department of Pathology, Sherman Oaks Community Hospital, Calif.
authors.forename: D G
authors.initials: DG
authors.lastname: Kahn
authors.forename: P J
authors.initials: PJ
authors.lastname: Rothman
authors.forename: J D
authors.initials: JD
authors.lastname: Weisman
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D006679:HIV Seropositivity; D006801:Humans; D016399:Lymphoma, T-Cell / Q000209:etiology* / Q000473:pathology; D008297:Male; D014523:Urethral Neoplasms / Q000209:etiology* / Q000473:pathology