A note on the action of glutamine on cortical spreading depression.
Application of a solution of 1-glutamine, 75 mM, to the pia-arachnoid surface of the dorsolateral neocortex of rabbits under dial-urethane anaesthesia was found to reversibly render the tissue insusceptible to spreading depression. It is suggested that this amide may play a part in the opposition normally offered by the tissue to undergo spreading depression. Some evidence is adduced which seems to support this suggestion.
Maranhão-Filho
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Neurology Service, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil.
Leão
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D000818:Animals; D001921:Brain / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D013181:Cortical Spreading Depression / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D005552:Forelimb / Q000502:physiology; D005973:Glutamine / Q000494:pharmacology*; D010812:Physical Stimulation; D011817:Rabbits
D005973:Glutamine