title: Assessment of 99mTc-HM-PAO parameters with SPECT for improved evaluation of blood flow in cerebral lesions.
abstract: A method for investigating the linearity between blood flow and distribution of 99mTc-HM-PAO uptake in patients undergoing single photon emission computed tomography (SPECT) is presented. This method, based on particular elaboration techniques of sequential multiple acquisitions, provides a local index: cumulative transit time (CTT) related to all factors, other than blood flow, affecting 99mTc-HM-PAO uptake. Because a correct qualitative blood flow estimation is based on the uniformity of the above factors, the occurrence of a change of this index indicates a nonlinear relation between blood flow and 99mTc-HM-PAO uptake distributions. It was shown that although linearity between blood flow and 99mTc-HM-PAO uptake may be questionable, a qualitative assessment of blood flow was correct in 100% of ischemic patients. In nonischemic patients this percentage fell to 60%.
authors.affiliation: Institute of Clinical Neurology, University of Genoa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bartolini
authors.forename: B
authors.initials: B
authors.lastname: Gasparetto
authors.forename: C
authors.initials: C
authors.lastname: Albano
authors.forename: G
authors.initials: G
authors.lastname: Ajmar
authors.forename: A
authors.initials: A
authors.lastname: Primavera
authors.forename: F
authors.initials: F
authors.lastname: Roncallo
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D015609:Organotechnetium Compounds; D010091:Oximes; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation*
chemical_list: D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime