Simultaneous renal and transitional cell carcinomas in same kidney with subsequent lymph node metastasis: DNA flow cytometric study.
We report the DNA content in simultaneous renal and papillary transitional cell carcinomas in the same kidney with a subsequent metastasis of the transitional cell carcinoma to a left supraclavicular lymph node. The flow cytometric DNA analysis revealed aneuploid stemlines with identical DNA indices in both the transitional cell carcinoma and the metastatic lesion and a diploid pattern in the renal cell carcinoma. A discussion of these findings and the potential implication of DNA ploidy analysis in similar situations is presented.
el-Naggar
A
A
Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston.
Ro
J Y
JY
Sella
A
A
Ayala
A G
AG
D000368:Aged; D000782:Aneuploidy; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology
D004273:DNA, Neoplasm