title: [Primary hemostasis in mixed connective tissue disease].
abstract: Willebrand-factor antigen level and structure analysis, ristomycin-cofactor assay, beta-thromboglobulin and thromboxane metabolite estimations were performed in 22 patients with mixed connective tissue disease. High levels of Willebrand factor antigen and activity were detected in the presence of thrombocytopenia, previous thrombotic events, pulmonary vascular lesions and in the presence of circulating antiendothelial antibodies. Increased platelet activation was documented also in antibody positive cases and in thrombocytopenia. The alterations of endothelial and platelet functions may play important role in the development of vascular complications of mixed connective tissue disease.
authors.affiliation: Debreceni Orvostudományi Egyetem, II. Belgyógyászati Klinika.
authors.forename: M
authors.initials: M
authors.lastname: Udvardy
authors.forename: E
authors.initials: E
authors.lastname: Bodolay
authors.forename: G
authors.initials: G
authors.lastname: Szegedi
authors.forename: J
authors.initials: J
authors.lastname: Hársfalvi
authors.forename: Z
authors.initials: Z
authors.lastname: Boda
authors.forename: K
authors.initials: K
authors.lastname: Rák
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000276:immunology; D004727:Endothelium / Q000166:cytology / Q000276:immunology; D005260:Female; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000097:blood* / Q000276:immunology; D014841:von Willebrand Factor / Q000276:immunology*
chemical_list: D014841:von Willebrand Factor
vernacular_title: A primer haemostasis vizsgálata kevert kötöszöveti betegségben.