title: Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance.
abstract: Twenty patients with irritable bowel syndrome due to food intolerance were randomized to either oral sodium cromoglycate or placebo in a double-blind cross-over trial. The study consisted of treatment with either sodium cromoglycate or placebo for 8 weeks, followed by the cross-over treatment for 8 further weeks. Patients were allowed to eat the offending foods during the study. Eighteen patients completed the study. Analysis of patients' diary card scores showed a statistically significant difference in favour of sodium cromoglycate. There was a long carry-over effect in the active-placebo order group. Therefore oral sodium cromoglycate seems to be a useful treatment in patients with irritable bowel syndrome and proven food intolerance.
authors.affiliation: Istituto Clinica Medica, Policlinico Borgo Roma, University of Verona, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Lunardi
authors.forename: L M
authors.initials: LM
authors.lastname: Bambara
authors.forename: D
authors.initials: D
authors.lastname: Biasi
authors.forename: P
authors.initials: P
authors.lastname: Cortina
authors.forename: P
authors.initials: P
authors.lastname: Peroli
authors.forename: F
authors.initials: F
authors.lastname: Nicolis
authors.forename: F
authors.initials: F
authors.lastname: Favari
authors.forename: M L
authors.initials: ML
authors.lastname: Pacor
mesh_terms: D000284:Administration, Oral; D000328:Adult; D003109:Colonic Diseases, Functional / Q000188:drug therapy* / Q000209:etiology*; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications*; D006801:Humans; D008297:Male
chemical_list: D004205:Cromolyn Sodium