title: Unusually long survival after autografting in second partial remission of translocation t(4;11) acute infant leukemia.
abstract: About 70% of children with acute lymphoblastic leukemia may be cured by conventional chemotherapy. The prognosis is considerably worse in infant leukemia with a translocation t(4;11). We report an infant with a diagnosis of cytochemically undifferentiated acute hybrid leukemia (pre pre B-ALL coexpressing one myelomonocytic marker) and t(4;11). Initial clinical presentation and the course of the disease were typical for t(4;11) acute leukemia. After an early hematologic relapse intensive chemotherapy resulted only in a second partial remission 7 months after initial diagnosis. Subsequent bone marrow transplantation with 16 mg/kg busulfan and 200 mg/kg cyclophosphamide followed by the infusion of autologous purged bone marrow resulted in a continuous second remission which has lasted 46 months so far.
authors.affiliation: St Anna Children's Hospital, Vienna, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Emminger
authors.forename: W
authors.initials: W
authors.lastname: Emminger-Schmidmeier
authors.forename: P
authors.initials: P
authors.lastname: Ambros
authors.forename: O A
authors.initials: OA
authors.lastname: Haas
authors.forename: P
authors.initials: P
authors.lastname: Höcker
authors.forename: U
authors.initials: U
authors.lastname: Köller
authors.forename: H
authors.initials: H
authors.lastname: Gadner
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000235:genetics / Q000601:surgery*; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D013997:Time Factors; D014178:Translocation, Genetic; D014182:Transplantation, Autologous