Oral cefadroxil prophylaxis in hip fracture surgery. Serum concentrations studied in 17 patients.
Serum concentration-time curves were determined in seventeen 82 (60-90) year-old patients undergoing trochanteric hip fracture surgery after receiving 1 g of cefadroxil per os. All the patients attained a serum level of antibiotic high enough to inhibit the growth of Staphylococcus aureus and S. epidermidis. When orally administered, cefadroxil should be given within 2 hours before surgery.
Nungu
K S
KS
Department of Orthopédics, University Hospital, Uppsala, Sweden.
Bengtsson
S
S
Olerud
C
C
Rehnberg
L
L
Larsson
S
S
D000368:Aged; D000369:Aged, 80 and over; D002434:Cefadroxil / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006620:Hip Fractures / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
D002434:Cefadroxil