[The characteristics of the effect of dipalmitoylphosphatidylcholine and its structural fragments on the lipid peroxidation of biological membranes].
The effect of dipalmitoyl phosphatidylcholine (DPPC) and its structural fragments--phosphatidic acid (PA) and choline chloride--on the ascorbate-dependent mice liver microsomal lipid peroxidation (LP) has been studied at the different LP rate. At DPPC, PA and choline chloride introduction into the incubation medium before the onset of peroxidation induction DPPC causes the more considerable inhibition of LP than PA each separate fragment. The inhibition effect of DPPC is lower than PA or choline chloride when DPPC, PA and choline chloride added on the background of developing process of peroxidation (e.i. after LP induction). A specific regulatory role of PC in the normal cell membrane LP process and during pathologic development is under discussion.
Burlakov
E B
EB
Aristarkhova
S A
SA
Fedorova
L V
LV
Sheludchenko
N I
NI
Shishkina
L N
LN
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000494:pharmacology*; D000818:Animals; D002794:Choline / Q000494:pharmacology*; D003864:Depression, Chemical; D004075:Diglycerides / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism
D004075:Diglycerides; D008563:Membrane Lipids; D015060:1,2-Dipalmitoylphosphatidylcholine; C005071:dipalmitin; D002794:Choline
Ossobennosti vliianiia dipal'mitoilfosfatidilkholina i ego strukturnykh fragmentov na perekisnoe okislenie lipidov biologicheskikh membran.