Could proteolytic enzyme modulate the interaction platelets/vessel wall in presence of ASA at ultra low doses?
Acetylsalicylic acid (ASA) is known to act on platelets and vessel walls. At ultra low doses it reverses the inhibitory effects produced by a vascular fragment. Use of papain on normal platelets in vitro led to the appearance of platelet aggregation without collagen induction with a range of 20.25 +/- 28.91%. In the presence of vascular fragments (without ASA), this "spontaneous" aggregation remained but was reduced (13.26 +/- 27.73%). This effect was reversed by ASA treatment (29.41 +/- 24.17%). Reversion of vascular inhibition by ASA was not modified by papain.
Lalanne
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MC
CJF Inserm 88/13, Laboratoire d'Hématologie, Bordeaux, France.
de Seze
O
O
Doutremepuich
C
C
Belon
P
P
D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D001808:Blood Vessels / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D010206:Papain / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects; D012996:Solutions
D012996:Solutions; D010206:Papain; D001241:Aspirin