Protective effect of cyanidin (IdB 1027) against aspirin-induced fall in gastric transmucosal potential difference in normal subjects.
The effect of the natural flavonoid cyanidin (IdB 1027), 1200mg daily for 8 days, on the fall in gastric transmucosal potential difference induced by a single dose of aspirin (1000mg by nasogastric tube) was evaluated in 7 normal male volunteers. As compared to pretreatment values, IdB 1027 caused a significant reduction in both the percentage fall in transmucosal potential difference at the time of peak aspirin effect (from 37 +/- 18% to 18 +/- 5%, p less than 0.05) and the area under potential difference baseline (from 811 +/- 624 mvolt. min to 338 +/- 150 mvolt. min, p less than 0.05). These results provide evidence for a protecting effect of IdB 1027 against aspirin-induced gastric mucosal damage in man.
Barzaghi
N
N
Dipartimento di Medicina Interna e Terapia Medica, Università di Pavia, Italy.
Gatti
G
G
Crema
F
F
Perucca
E
E
D000328:Adult; D000872:Anthocyanins; D001241:Aspirin / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000502:physiology*; D006801:Humans; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects
D000872:Anthocyanins; D001578:Benzopyrans; C017154:cyanidin; D001241:Aspirin