title: Improved iodine-125 plaque design in the treatment of choroidal malignant melanoma.
abstract: The use and development of iodine-125 plaque therapy for choroidal malignant melanoma are described. Since 1975 experience has led to changes in plaque design and insertion techniques. Twenty-one patients were irradiated with local episcleral iodine-125 plaques. Three patients required a second plaque for tumour recurrence. Four eyes were enucleated because of continued tumour growth and a further eye was removed because of glaucoma secondary to radiation retinopathy. Two patients (9.5%) died of metastases. The remaining 19 patients are alive and clinically clear of metastases, with a mean follow up time of 73.1 months (range 43-142 months).
authors.affiliation: Department of Ophthalmology, Groote Schuur Hospital.
authors.forename: J C
authors.initials: JC
authors.lastname: Hill
authors.forename: R
authors.initials: R
authors.lastname: Sealy
authors.forename: D
authors.initials: D
authors.lastname: Shackleton
authors.forename: C
authors.initials: C
authors.lastname: Stannard
authors.forename: J
authors.initials: J
authors.lastname: Korrubel
authors.forename: E
authors.initials: E
authors.lastname: Hering
authors.forename: C
authors.initials: C
authors.lastname: Loxton
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D002830:Choroid Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D015353:Eye Enucleation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D011879:Radiotherapy Dosage
chemical_list: D007457:Iodine Radioisotopes