Cognitive recovery correlates with long-term increases of cerebral perfusion after head injury.
Prospective measurements of cerebral blood flow (CBF) and Cognitive Capacity Screening Examination (CCSE) were obtained following head injury among 42 patients for a mean total follow-up interval of 10 years. Clinical data obtained at the time of injury and detailed neurological examinations at each follow-up visit were correlated with serial CBF and CCSE scores. Comparisons of the group of patients who cognitively improved (n = 32) were made with the group that did not (n = 10). Of the total group, 76% showed cognitive improvements for as long as 10 years after injury, with CBF increases toward normal. Predictors for long-term cognitive improvements include: higher initial Glasgow Coma Scales, earlier recovery from coma, absence of signs of brain stem injury, and improvements of cerebral perfusion and autoregulation. Failure to improve correlated with low initial Glasgow Coma Scales, signs of brain stem injury, and persistent impairments of cerebral perfusion.
Terayama
Y
Y
Cerebral Blood Flow Laboratory, Department of Veterans Affairs Medical Center, Houston, Texas 77211.
Meyer
J S
JS
Kawamura
J
J
D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001930:Brain Injuries / Q000503:physiopathology* / Q000523:psychology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002648:Child; D003071:Cognition / Q000502:physiology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors