Evidence of mononuclear cell activation by hemodialysis.
The acute effects of hemodialysis (HD) on activation and function of mononuclear cells (MC) were studied in a model of in vitro HD. During the HD session, both cuprophan (CU) and polysulfone (PS) induced transcription of interleukin-2 receptor (IL-2R) mRNA. Expression of IL-2R on the cytoplasmic membrane, and release of soluble IL-2R (sIL-2R), however, did not change during HD, nor did responsiveness to IL-2. Polysulfone caused a slight reduction of the proliferative response to phypohemagglutinin, and of the release of sIL-2R. Hemodialysis did not induce IL-2 production, but induced IL-1 synthesis.
Donati
D
D
Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway.
Degiannis
D
D
Combates
N
N
Raskova
J
J
Raska
K
K
D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy*; D008213:Lymphocyte Activation / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology
D007375:Interleukin-1; D007376:Interleukin-2; D015375:Receptors, Interleukin-2