[Prognostic significance of plasma renin activity and aldosterone levels in patients with chronic cardiac insufficiency].
Minor biochemical changes in the renin-angiotensin-aldosterone system play a significant role in the formation of clinical chronic heart failure (CHF). Classifying heart failure by the activity of plasma renin identifies 3 large patient groups that are characterized by low, normal or high renin activity. If aldosterone is included into its characterization, the groups should be divided into subgroups by plasma aldosterone levels. The biochemical "profiling" of patients in terms of renal and adrenal hormones may be widely applied to the prediction and individually selected therapy of CHF patients. The present study has demonstrated that in contrast to individuals with normal or high renin activity and of the same age and the same degree of heart failure, patients with its low levels are better protected against arrhythmias and severe and therapy-resistant heart failure. In severe CHF aldosterone concentrations are virtually higher at any time.
Kiknadze
M P
MP
D000450:Aldosterone / Q000097:blood*; D002303:Cardiac Output, Low / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D011379:Prognosis; D012083:Renin / Q000097:blood*; D012084:Renin-Angiotensin System
D000450:Aldosterone; D012083:Renin
Prognosticheskoe znachenie aktivnosti renina i kontsentratsii al'dosterona v plazme krovi u bol'nykh s khronicheskoĭ serdechnoĭ nedostatochnost'iu.