title: Chronic evaluation of a compact nonseal magnet pump as a nonpulsatile pump for long-term use.
abstract: Use of a nonpulsatile pump is one of the most interesting approaches in the development of artificial hearts. A centrifugal pump without a seal around the rotating part was evaluated in five goats. The size of the pump is 8.4 cm x phi 7.0 cm, including an electric motor. A polypropylene impeller with four fins on the top of a column in which a magnetic ring is embedded spins by coupling with a rotating magnet outside the housing. In the goats, the pump was placed paracorporeally to provide total left heart bypass at a flow rate of 4.6-7.6 L/min, and activated clotting time was controlled at 200-300 sec by continuous heparin infusion. Although the first three goats died within 3 days due to bleeding, embolism, and a jammed impeller, respectively, a pump could be driven for 14 days in the fourth goat, and another pump with a rotational control feedback system ran for 32 days in the fifth goat. Plasma free hemoglobin levels were 13.8 +/- 4.3 mg/dl and 9.5 +/- 2.5 mg/dl, and platelet counts were 53.8 +/- 24.7 x 10(4)/mm3 and 62.0 +/- 22.0 x 10(4)/mm3 after 12 hours and 7 days pumping, respectively. No thrombus was observed in the blood chamber in the last two cases. In conclusion, this pump has possibilities as a nonpulsatile pump for long-term use.
authors.affiliation: Department of Artificial Organs, National Cardiovascular Center, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Taenaka
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: M
authors.initials: M
authors.lastname: Sakaki
authors.forename: E
authors.initials: E
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Masuzawa
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: H
authors.initials: H
authors.lastname: Akagi
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Inoue
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests; D011211:Electric Power Supplies; D055590:Electromagnetic Phenomena / Q000295:instrumentation; D005340:Fibrinogen / Q000378:metabolism; D006041:Goats; D006354:Heart, Artificial; D006452:Hemoglobinometry; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010976:Platelet Count; D011474:Prosthesis Design
chemical_list: D005340:Fibrinogen; D007770:L-Lactate Dehydrogenase