title: Somatic cell mutations in atomic bomb survivors.
abstract: Mutant frequencies in peripheral blood lymphocytes and erythrocytes have been measured for atomic bomb survivors having various DS86 doses. Among the four assay systems utilized so far, erythrocyte glycophorin A assay revealed a dose related increase of mutant frequency, similar to the results obtained with in vitro mutagenesis studies at HPRT locus using human diploid cells. Mutant T-lymphocyte frequency of the HPRT locus detected as resistant to 6-thioguanine significantly increased with DS86 dose however the slope was very shallow compared with that of in vitro study. Mutation at T-cell receptor genes and the HLA-A gene did not show a significant increase in frequency with dose in cells of survivors studied.
authors.affiliation: Department of Radiobiology, Radiation Effects Research Foundation, Hiroshima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Akiyama
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Hakoda
authors.forename: S
authors.initials: S
authors.lastname: Kyoizumi
authors.forename: J
authors.initials: J
authors.lastname: Kushiro
authors.forename: Y
authors.initials: Y
authors.lastname: Hirai
authors.forename: Y
authors.initials: Y
authors.lastname: Kusunoki
mesh_terms: D006801:Humans; D007564:Japan; D009154:Mutation / Q000235:genetics*; D009689:Nuclear Warfare; D011831:Radiation Genetics; D013534:Survival