Rapid onset of blindness due to meningeal carcinomatosis from an oesophageal adenocarcinoma.
We report a 49 year old man who presented with left leg weakness, frontal headache, impaired concentration and dysphagia. He was thought to have a benign oesophageal stricture on barium swallow and oesophagoscopy though this was not initially biopsied. During admission his vision deteriorated so that he could only recognize bright light. Repeat oesophagoscopy demonstrated an oesophageal adenocarcinoma. The diagnosis of meningeal carcinomatosis was confirmed at post-mortem. Sudden bilateral blindness is a common feature of meningeal carcinomatosis but, as this is rare, it is not commonly considered in the differential diagnosis of visual loss. The visual loss can be explained by vascular insufficiency in association with tumour cuffing of the subarachnoid space of the optic nerve sheath, by neuronal toxins, or other, as yet unknown, mechanisms.
Teare
J P
JP
Department of Medicine, Kent and Canterbury Hospital, UK.
Whitehead
M
M
Rake
M O
MO
Coker
R J
RJ
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology; D001766:Blindness / Q000209:etiology*; D002277:Carcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D004938:Esophageal Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology