[Cytochrome P-450 activity and lipid peroxidation in rat liver and lung microsomes during hypoxia and followed by pressure oxygenation].
Influence of hypoxia (0.029 MPa, I h) followed by hyperoxia (0.2 MPa, I h) on microsomal oxidation and lipoperoxidation was studied in rat liver and lungs. Distinct increase of cytochrome P-450 catalytic activity with amidopyrine and benzo-a-pyrene as substrates of the I type was found after hypoxia, subsequent hyperoxia resulted in significant increase of amidopyrine and benzo-a-pyrene metabolism in liver and lung tissues and of aniline metabolism in liver tissue. Both hypoxia and hyperoxia led to increase in content of diene conjugates and Schiff bases in liver and lungs, while the increase of diene conjugates in liver and both diene conjugates and Schiff bases in lungs were observed under hyperoxic conditions.
Shugaleĭ
V S
VS
Ananian
A A
AA
Sadekova
S I
SI
Miliutina
N P
NP
D000632:Aminopyrine / Q000633:toxicity; D000818:Animals; D001564:Benzo(a)pyrene / Q000633:toxicity; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006931:Hyperbaric Oxygenation; D000860:Hypoxia / Q000378:metabolism*; D015227:Lipid Peroxidation; D008168:Lung / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D051381:Rats
D000632:Aminopyrine; D001564:Benzo(a)pyrene; D003577:Cytochrome P-450 Enzyme System
Aktivnost' tsitokhroma P-450 i perekisnogo okisleniia lipidov v mikrosomakh pecheni i legkikh krys v usloviiakh gipoksii i posleduiushcheĭ barooksigenatsii.