title: Assignment of tyrosine-specific T-cell phosphatase to conserved syntenic groups on human chromosome 18 and mouse chromosome 18.
abstract: Phosphorylation of proteins on tyrosine is crucially involved in signal transduction and mitogenesis and is regulated by both kinases and phosphatases. Recently, a number of soluble and transmembrane receptor-linked protein tyrosine phosphatases (PTPase) have been characterized. Among these is a 48.4-kDa PTPase encoded by a cDNA isolated from a T-lymphocyte library by low-stringency screening with probes derived from placental PTPase 1B. A human T-cell PTPase (PTPT) cDNA and somatic cell hybrids were used to assign a PTPT gene to conserved syntentic groups on human chromosome 18 and on mouse chromosome 18. Two unlinked sequences, one on human chromosome 1, were also detected.
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
authors.forename: A Y
authors.initials: AY
authors.lastname: Sakaguchi
authors.forename: V L
authors.initials: VL
authors.lastname: Sylvia
authors.forename: L
authors.initials: L
authors.lastname: Martinez
authors.forename: E A
authors.initials: EA
authors.lastname: Smith
authors.forename: E S
authors.initials: ES
authors.lastname: Han
authors.forename: P A
authors.initials: PA
authors.lastname: Lalley
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: G G
authors.initials: GG
authors.lastname: Choudhury
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D013601:T-Lymphocytes / Q000201:enzymology*
chemical_list: D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases