[Role of sinusoidal cells in the morphogenesis of alcoholic liver cirrhosis].
49 liver biopsies in alcoholic liver damage (fibrosis, chronic persisting hepatitis, cirrhosis) are studied on semithin sections electron microscopically and morphometrically. Morphological varieties of hepatocytes and sinusoidal cells are revealed as well as some rules in their proportions. Domination of stellate reticulo-endotheliocytes with a high secretory and phagocyte activity correlates with high adaptive properties of hepatocytes and transformation of lipocytes into fibroblast-like cells without development of intralobular fibrosis. If nonactive variant of the stellate reticulo-endotheliocytes prevails, the number of damaged hepatocytes and fibroblast-like lipocytes increases, intralobular fibrosis becomes pronounced resulting in hepatocyte death. Role of sinusoidal cells in realization of alcoholic cirrhosis morphogenesis is discussed.
Beketova
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D001706:Biopsy; D006521:Hepatitis, Chronic / Q000473:pathology; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000473:pathology*; D008854:Microscopy, Electron
Rol' sinusoidal'nykh kletok v morfogeneze alkogol'nogo tsirroza pecheni.