title: [Chemotherapy with cisplatin and 5-fluorouracil in inoperable brain metastases of bronchopulmonary cancers].
abstract: Chemotherapy is not a common treatment for cerebral metastases. The authors report results of combination chemotherapy with cisplatin (CDDP) and fluorouracil (5-FU). Sixteen men (age range 31-73 years) with brain metastases were treated with CDDP 20 mg/m2/day in continuous infusion for 5 days (d 1-5) and 5-FU 1 g/m2/day in continuous infusion for 4 days (d 1-4), and the treatment schedule repeated every 3 weeks. A brain computerized tomography after 2, 4 and 6 cycles was performed to assess efficacy. It was considered that complete response was achieved if no lesion was found on the CT scan, and partial response if at least half of the total volume had decreased. After 2 cycles, the response rate was therefore 8/16 (50%). Treatment toxicity was very mild with only 1 case of severe but reversible myelotoxicity (grade III). It is concluded that chemotherapy combination with CDDP and 5-FU is a useful treatment for brain metastasis of lung carcinoma.
authors.affiliation: Service de pneumologie et d'oncologie bronchopulmonaire, CHU Morvan, Brest, France.
authors.forename: G
authors.initials: G
authors.lastname: Robinet
authors.forename: S
authors.initials: S
authors.lastname: Gouva
authors.forename: J
authors.initials: J
authors.lastname: Clavier
authors.forename: P
authors.initials: P
authors.lastname: Richard
authors.forename: F
authors.initials: F
authors.lastname: Rouhart
authors.forename: Y
authors.initials: Y
authors.lastname: Mocquard
authors.forename: J Y
authors.initials: JY
authors.lastname: Goas
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004453:Echoencephalography; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Chimiothérapie par cisplatine et 5-fluorouracile dans les métastases cérébrales inopérables des cancers bronchopulmonaires.