Response to autoimmune enteropathy to cyclosporin A therapy.
Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is useful in the treatment of autoimmune enteropathy. This report also suggests that T cell activation (which is suppressed by cyclosporin A) is important in the pathogenesis of this condition.
Sanderson
I R
IR
Academic Unit of Paediatric Gastroenterology, Queen Elizabeth Hospital for Children, London.
Phillips
A D
AD
Spencer
J
J
Walker-Smith
J A
JA
D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007410:Intestinal Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007421:Intestine, Small / Q000648:ultrastructure; D008297:Male
D016572:Cyclosporine; D005947:Glucose