Occurrence of resistance to vibriostatic compound 0/129 in Vibrio cholerae 01 isolated from clinical and environmental samples in Bangladesh.
Fifty-one Vibrio cholerae 01 strains isolated from 734 natural water and plankton samples and 31 rectal swabs were examined. Of these strains, 32 (62.7%) were found to be resistant to vibriostatic compound 0/129. When antibiograms using the antibiotics ampicillin, tetracycline, chloramphenicol, trimethoprim-sulfamethoxazole, furoxan, and gentamicin were done, it was observed that there was a correlation of sensitivity to 0/129 with selected antibiotics. Only the Ogawa E1 Tor (72% of strains resistant) and Inaba classical (28% of strains resistant) biotypes of V. cholerae 01 showed resistance to 0/129. On the other hand, all Inaba E1 Tor and Ogawa classical strains were susceptible to 0/129. The 32 0/129-resistant and 19 0/129-sensitive isolates of V. cholerae 01 were tested for the presence of plasmid DNA. Only two strains isolated from the environment were found to carry a plasmid, and they were also found to be resistant to 0/129 and gentamicin. Thus, 0/129 resistance, although more common than previously suspected, is concluded not to be plasmid mediated in the strains tested in this study.
Huq
A
A
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Alam
M
M
Parveen
S
S
Colwell
R R
RR
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001459:Bangladesh; D004352:Drug Resistance, Microbial; D006801:Humans; D010933:Plankton; D011621:Pteridines / Q000494:pharmacology*; D014734:Vibrio cholerae / Q000187:drug effects* / Q000302:isolation & purification; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D011621:Pteridines; C021594:O 129