title: Outcome of hepatic amebic abscesses managed with three different therapeutic strategies.
abstract: Three different approaches to hepatic abscesses due to Entamoeba histolytica were compared in 51 patients. The three modes of therapy utilized were: medical therapy with nitroimidazoles (N = 11 patients), open surgical drainage (N = 9 patients), and percutaneous drainage using ultrasound guidance followed by intralesional nitroimidazole administration (N = 31 patients). The results with each form of therapy were assessed clinically and by abdominal ultrasound. Patients receiving combined US-guided drainage and intralesional chemotherapy experienced a faster and overall better clinical response, which was confirmed also by sonographic follow-up of the hepatic lesions. This better response was associated with faster resolution, fewer relapses, and less residual hepatic scarring than either with medical therapy alone or open surgical drainage combined with medical therapy.
authors.affiliation: Department of Infectious Diseases, University of Pavia School of Medicine, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Filice
authors.forename: G
authors.initials: G
authors.lastname: Di Perri
authors.forename: M
authors.initials: M
authors.lastname: Strosselli
authors.forename: E
authors.initials: E
authors.lastname: Brunetti
authors.forename: S
authors.initials: S
authors.lastname: Dughetti
authors.forename: D H
authors.initials: DH
authors.lastname: Van Thiel
authors.forename: C
authors.initials: C
authors.lastname: Scotti-Foglieni
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D004322:Drainage / Q000379:methods; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008101:Liver Abscess, Amebic / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use; D014463:Ultrasonography
chemical_list: D009593:Nitroimidazoles