Effect of benzopyrone derivatives on simultaneously induced croton oil ear oedema and carrageenin paw oedema in rats.
Carrageenin paw oedema and croton oil ear oedema induced simultaneously in rats are inhibited in a dose-dependent manner and to statistically significant degrees by lipoxygenase- and cyclooxygenase-blocker flavonoids (diosmin, fisetin, quercetin, myricetin, galangin, sophoricoside, hesperidin-methylchalcone, oligomeric procyanidin, anthocyanidins (delphinidin, pelargonidin], and the prostaglandin antagonist polyphloretin phosphate and di-4-phloretin phosphate. Outstanding anti-inflammatory effects are displayed by myricetin and delphinidin, which contain vicinal hydroxy groups in ring B. The results confirm the importance of hydroxy group substitution in ring B. The most effective of the examined substances proved to be the prostaglandin antagonist di-4-phloretin phosphate.
Gábor
M
M
Department of Pharmacodynamics, Albert-Szent Györgyi University Medical School, Hungary.
Rázga
Z
Z
D000818:Animals; D002351:Carrageenan; D003436:Croton Oil; D004423:Ear; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005419:Flavonoids / Q000494:pharmacology*; D005528:Foot; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D011121:Polyphloretin Phosphate / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005419:Flavonoids; D011448:Prostaglandin Antagonists; C013509:diphloretin phosphate; D003436:Croton Oil; D002351:Carrageenan; D011121:Polyphloretin Phosphate