Chondroitin sulfate as a regulator of neuronal patterning in the retina.
Highly sulfated proteoglycans are correlated with axon boundaries in the developing central nervous system which suggests that these molecules affect neural pattern formation. In the developing mammalian retina, gradual regression of chondroitin sulfate may help control the onset of ganglion cell differentiation and initial direction of their axons. Changes induced by the removal of chondroitin sulfate from intact retinas in culture confirm the function of chondroitin sulfate in retinal histogenesis.
Brittis
P A
PA
Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106.
Canning
D R
DR
Silver
J
J
D000818:Animals; D001369:Axons / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002808:Chondroitin Lyases / Q000494:pharmacology; D011508:Chondroitin Sulfate Proteoglycans / Q000494:pharmacology; D002809:Chondroitin Sulfates / Q000032:analysis / Q000502:physiology*; D007150:Immunohistochemistry; D051381:Rats; D012160:Retina / Q000737:chemistry / Q000166:cytology / Q000196:embryology*; D012165:Retinal Ganglion Cells / Q000737:chemistry / Q000166:cytology*; D014404:Tubulin / Q000032:analysis
D011508:Chondroitin Sulfate Proteoglycans; D014404:Tubulin; D002809:Chondroitin Sulfates; D002808:Chondroitin Lyases