title: In vitro hemodynamic analysis of flexible artificial ventricles.
abstract: An in vitro fluid dynamic study was performed to compare the hemodynamic characteristics of a rigid and a flexible total artificial heart. The artificial ventricles were incorporated into a mock circulatory system, and pressure signals within the ventricular chamber, proximal to the inflow valve and distal to the outflow valve, were obtained. The instantaneous flow rate through the inflow and outflow valves was measured with electromagnetic flow probes. Flow visualization studies performed on the flexible ventricle suggested a vortical motion within the chamber with a smooth washout of fluid in the next pumping phase, but flow disturbances were observed near the wall of the ventricle as well as near the outflow valve. The rate of pressure increase (dP/dt) was smaller in the flexible ventricle as compared with the rigid ventricle for comparable flows and heart rates. The results of the present study indicated that the flexible ventricle with polyurethane valves, having the advantage of ease of implantation and cost savings, can be a viable alternative as a bridge to transplant.
authors.affiliation: Department of Biomedical Engineering, University of Iowa, Iowa City 52242.
authors.forename: K B
authors.initials: KB
authors.lastname: Chandran
authors.forename: C S
authors.initials: CS
authors.lastname: Lee
authors.forename: T
authors.initials: T
authors.lastname: Shipkowitz
authors.forename: L D
authors.initials: LD
authors.lastname: Chen
authors.forename: L S
authors.initials: LS
authors.lastname: Yu
authors.forename: D
authors.initials: D
authors.lastname: Wurzel
mesh_terms: D006354:Heart, Artificial; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D008961:Models, Structural; D011140:Polyurethanes; D011474:Prosthesis Design
chemical_list: D011140:Polyurethanes