The effect of adjuvant-induced arthritis on rat leukocyte membrane phospholipid fatty acid levels following fish oil feeding.
Inflamed rats with adjuvant-induced polyarthritis showed similar incorporation of dietary eicosapentaenoic acid (EPA) into peritoneal exudate cell (PEC) membrane phospholipids compared to pair fed non-inflamed control rats. Arachidonic acid (AA) content was similar in PEC phospholipids of inflamed and control rats whereas the linoleic acid content was consistently higher in inflamed rats.
Hawkes
J S
JS
Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Australia.
Cleland
L G
LG
Gibson
R A
RA
James
M J
MJ
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D001169:Arthritis, Experimental / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D015118:Eicosapentaenoic Acid / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005395:Fish Oils / Q000008:administration & dosage*; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D010529:Peritoneal Cavity / Q000166:cytology; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D005395:Fish Oils; D010743:Phospholipids; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid