Management of oral mucosal dysplasia with beta-carotene retinoic acid: a pilot cross-over study.
Mucosal dysplasia in the head and neck region is recognized to be a precancerous lesion. Between January 1983 and December 1987, a pilot study was conducted at the Manitoba Cancer Treatment and Research Foundation to determine the effects of beta-carotene and cis-retinoic acid on mucosal dysplasias. Eighteen patients were treated with a "cross-over" regimen. The overall response to treatment was 61%, with 33.3% complete responses. Patients who smoked had a significantly better response than nonsmokers. The response rate for 9 of 11 smokers was 81.2%, and 2 of 7 nonsmokers or 28.6% responded to this protocol. The beneficial effect of these drugs should be established by prospective, randomized trial in high risk populations.
Malaker
K
K
Department of Radiation Oncology, Manitoba Cancer Foundation, Winnipeg, Canada.
Anderson
B J
BJ
Beecroft
W A
WA
Hodson
D I
DI
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002338:Carotenoids / Q000097:blood / Q000627:therapeutic use*; D004341:Drug Evaluation; D004919:Erythroplasia / Q000188:drug therapy; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000188:drug therapy; D008010:Lichen Planus / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000097:blood / Q000188:drug therapy*; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D010865:Pilot Projects; D011230:Precancerous Conditions / Q000097:blood / Q000188:drug therapy*; D011446:Prospective Studies; D012907:Smoking; D014212:Tretinoin / Q000627:therapeutic use*; D014801:Vitamin A / Q000097:blood; D019207:beta Carotene
D019207:beta Carotene; D014801:Vitamin A; D002338:Carotenoids; D014212:Tretinoin