A Drosophila melanogaster H3.3 cDNA encodes a histone variant identical with the vertebrate H3.3.
A cDNA encoding an H3.3 histone variant in Drosophila melanogaster predicts a protein with an amino acid (aa) sequence identical with that in vertebrates. The D. melanogaster H3.3 nucleotide (nt) sequence has diverged significantly from that of both the H3.3 gene of vertebrates and the H3.1 gene of D. melanogaster, largely through third nt changes in its codons. The perfect H3.3 aa sequence conservation between organisms as phylogenetically divergent as vertebrates and flies suggests that the H3.3 histone variant itself is an important structural component of chromatin, apart from the value of its replication-independent expression pattern.
Fretzin
S
S
Department of Biology, Washington University, St. Louis, MO 63130.
Allan
B D
BD
van Daal
A
A
Elgin
S C
SC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002843:Chromatin; D004331:Drosophila melanogaster / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D006657:Histones / Q000235:genetics*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid
D002843:Chromatin; D006657:Histones