title: Performance evaluation of hydroxylated and acylated silicone rubber coatings.
abstract: Hydroxylated and C16 acylated silicone rubber films were prepared with enhanced albumin binding. Lee-White clotting times were significantly increased for both treatments. Hydroxylation significantly reduced C5a production. Hydroxylated silicone rubber femoral vein catheters in canines reduced 111In-labeled platelet activity, compared with bilateral silicone rubber catheter controls. The results suggest hydroxylated silicone rubber films have enhanced biocompatibility.
authors.affiliation: Bioengineering Program, University of Texas Southwestern Medical Center, Dallas 75235-9031.
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: M L
authors.initials: ML
authors.lastname: Dollar
authors.forename: A
authors.initials: A
authors.lastname: Constantinescu
authors.forename: P V
authors.initials: PV
authors.lastname: Kulkarni
authors.forename: R C
authors.initials: RC
authors.lastname: Eberhart
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001777:Blood Coagulation; D001807:Blood Vessel Prosthesis; D003167:Complement Activation; D004285:Dogs; D006801:Humans; D010974:Platelet Aggregation; D011108:Polymers; D012826:Silicone Elastomers; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D012826:Silicone Elastomers