title: Studies on the anticonvulsive, sedative and hypothermic effects of Periostracum Cicadae extracts.
abstract: The anticonvulsive, sedative and hypothermic effects of water and ethanol extracts of Periostracum Cicadae (PC), the cast off skin of Cryptotympana atrata were studied. The water-extract of whole Periostracum Cicadae (PCws) had anticonvulsive, sedative and hypothermic effects in rats. Orally, it decreased carrageenin-induced hyperthermia. The hypothermic effect of PCws was potentiated by 5-hydroxytryptophan and antagonized by p-chlorophenylalanine. PCws enhanced the decrease in locomotor activity induced by alpha-methyl-p-tyrosine or 5-hydroxytryptophan and reduced the increase in locomotor activity produced by levodopa plus benserazide or p-chlorophenylalanine. From these results, it was concluded that the sedative and hypothermic effect of PCws may be due to an increase in central serotonergic activity.
authors.affiliation: Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
authors.forename: M T
authors.initials: MT
authors.lastname: Hsieh
authors.forename: W H
authors.initials: WH
authors.lastname: Peng
authors.forename: F T
authors.initials: FT
authors.lastname: Yeh
authors.forename: H Y
authors.initials: HY
authors.lastname: Tsai
authors.forename: Y S
authors.initials: YS
authors.lastname: Chang
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000633:toxicity*; D000927:Anticonvulsants / Q000302:isolation & purification / Q000633:toxicity*; D001831:Body Temperature / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000302:isolation & purification / Q000633:toxicity*; D007313:Insecta; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives