Reduced cholecystokinin in the brain of LEC rats with hepatic encephalopathy.
Levels of cholecystokinin (CCK) immunoreactivity and distribution of CCK immunoreactive cells were studied in the cerebral cortex of LEC (Long Evans Cinnamon) rats with hepatic encephalopathy. CCK immunoreactivity in water extract of cerebral cortex of LEC rats with hepatic encephalopathy (n = 7) was 41.5 +/- 2.6 (mean +/- S.E.M. pmol/g wet wt.) and that of LEC rats without encephalopathy (n = 8) was 67.1 +/- 6.9, the difference being significant (P less than 0.01). CCK immunoreactive cells assessed by immunohistochemistry were also markedly decreased in the cortex of LEC rats with hepatic encephalopathy of stage IV. Thus, CCK reduction was observed in the cerebral cortex of LEC rats with hepatic encephalopathy which are provided as a model for analysis of the pathogenesis of acute hepatic encephalopathy.
Tateishi
K
K
First Department of Biochemistry, School of Medicine, Fukuoka University, Japan.
Miura
Y
Y
Madarame
T
T
Yoshida
T
T
Suzuki
K
K
Takeichi
N
N
Kobayashi
H
H
Matsuoka
Y
Y
Sato
S
S
D000596:Amino Acids / Q000097:blood; D000641:Ammonia / Q000097:blood; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D002766:Cholecystokinin / Q000378:metabolism*; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D000641:Ammonia; D002766:Cholecystokinin