title: Analgesia by nefopam: does it act through serotonin?
abstract: In an attempt to clarify the possible mode of action of nefopam, a new analgesic compound, the authors tested its effects on imipramine (IMI) binding to platelet membranes. The results showed that nefopam exerted a concentration-dependent inhibition of IMI binding, with a potency comparable to that of tricyclic antidepressants. This finding suggests a possible intervention of serotonergic mechanisms in nefopam-related analgesia.
authors.affiliation: Institute of the Psychiatric Clinic, University of Pisa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Marazziti
authors.forename: A
authors.initials: A
authors.lastname: Rotondo
authors.forename: F
authors.initials: F
authors.lastname: Ambrogi
authors.forename: G B
authors.initials: GB
authors.lastname: Cassano
mesh_terms: D000698:Analgesia; D001792:Blood Platelets / Q000187:drug effects; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007099:Imipramine / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D009020:Morphine / Q000494:pharmacology; D009340:Nefopam / Q000494:pharmacology*; D009966:Orphenadrine / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D012702:Serotonin Antagonists; D009340:Nefopam; D009020:Morphine; D009966:Orphenadrine; D007099:Imipramine; D003891:Desipramine