[Vaccination against hepatitis B virus at the Lyon Pasteur Institute. A seven-year evaluation].
Results of immunization against hepatitis B among Pasteur Institute staff members are reported. Prior to immunization, 439 subjects were tested for hepatitis B virus (HBV) markers, including HBs antigen, anti-HBs antibody, and anti-HBc antibody (Ausria, Ausab, Corab assays; Abbott). Forty-seven subjects tested positive for anti-HBs antibody. 317 subjects negative for all the HBs markers studied were given three intramuscular doses of Hevac B (Pasteur vaccins) at one-month intervals. Anti-HBs antibodies were assayed after the third injection with the following results: mean titer, 1,454 mIU/ml, standard deviation, 5,349 mIU/ml, and range, 4 to 41,100 mIU/ml. Anti-HBs titers above 10 mIU/ml were found in 879.4% of subjects. Non-responders and weak responders (anti-HBs titer under 10 mIU/ml) were given a fourth dose of vaccine. Ultimately, after the last (third of fourth) injection 97.6% of subjects had protective antibody titers. No case of HBV infection was seen during the seven-year follow-up period.
Fayol
V
V
Centre de Radioanalyse, Institut Pasteur de Lyon, France.
Cotisson
A
A
Jullien
C
C
Rotivel
Y
Y
Lery
L
L
Ville
G
G
D000328:Adult; D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006282:Health Personnel; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014611:Vaccination / Q000706:statistics & numerical data*
D006510:Hepatitis B Antibodies
Vaccination contre le virus de l'hépatite B à l'Institut Pasteur de Lyon. Bilan de sept ans.