title: Detection of infection in postoperative orthopedic patients with technetium-99m-labeled monoclonal antibodies against granulocytes.
abstract: A prospective study of 106 orthopedic patients was performed for the detection of infection in the early postoperative stage using 99mTc-labeled murine Mabs directed against epitopes on granulocytes. Accuracy was 81% in the hips (n = 26), 81% in the thigh (n = 21), 84% in the knee (n = 19), and 100% in the tibia (n = 27). The technique did not work well in the spine where false-negative results were observed in the three patients studied. One patient suffered transient swelling of the eyelids following injection. Optimal imaging results were obtained 2-6 hr postinjection.
authors.affiliation: Department of Nuclear Medicine, University of Tübingen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Reuland
authors.forename: K H
authors.initials: KH
authors.lastname: Winker
authors.forename: T
authors.initials: T
authors.lastname: Heuchert
authors.forename: P
authors.initials: P
authors.lastname: Ruck
authors.forename: W
authors.initials: W
authors.lastname: Müller-Schauenburg
authors.forename: S
authors.initials: S
authors.lastname: Weller
authors.forename: U
authors.initials: U
authors.lastname: Feine
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009985:Orthopedics; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D011446:Prospective Studies; D016719:Radioimmunodetection; D013667:Technetium
chemical_list: D013667:Technetium