title: Effect of sucrose consumption on alcohol-induced impairment in male social drinkers.
abstract: Two studies were conducted to examine the interaction between sucrose and ethanol in normal young fasting adult males. The first experiment employed a 3 (100 g sugar, 35 g sugar, 0 g sugar) x 3 (alcohol, placebo and sober) factorial design, which was carried out double-blind using aspartame to ensure that all the drinks were equally sweet. Subjects were tested for mood, memory, subjective intoxication and psychomotor performance at baseline and at times up to 3.5 h after ingestion of the drinks. An alcohol by sugar interaction was seen at 0.5 after drinking. Sugar attenuated alcohol intoxication at this time without influencing blood alcohol levels. Contrary to previous reports, the combination of alcohol and sugar failed to produce significant hypoglycemia, or any of the adverse behavioral effects associated with hypoglycemia, at later times after drink ingestion. The second experiment involved a simpler design, carried out single-blind in which the subjects receiving no sugar did not get aspartame. This was to rule out the possibility that aspartame was exacerbating alcohol intoxication instead of sugar attenuating it. The second experiment also showed that sugar can attenuate alcohol intoxication in fasting humans without altering blood alcohol levels significantly.
authors.affiliation: Department of Psychology, McGill University, Montréal, Québec, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Zacchia
authors.forename: R O
authors.initials: RO
authors.lastname: Pihl
authors.forename: S N
authors.initials: SN
authors.lastname: Young
authors.forename: F R
authors.initials: FR
authors.lastname: Ervin
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D000435:Alcoholic Intoxication / Q000523:psychology*; D001786:Blood Glucose / Q000378:metabolism; D000431:Ethanol / Q000097:blood; D005260:Female; D006801:Humans; D008568:Memory / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D013395:Sucrose / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D000431:Ethanol; D013395:Sucrose