Hemorrhage associated with "bone crisis" in Gaucher's disease identified by magnetic resonance imaging.
Children suffering from Gaucher's disease were examined by magnetic resonance imaging (MRI) during a characteristic episode of "bone crisis". An unexpectedly high intramedullary as well as subperiosteal signal was observed on both the T1- and T2-weighted sequences in 5 patients, suggesting a subacute hemorrhage or hematoma. It is conceivable that such a painful hemorrhage is an important component of the "bone crisis" phenomenon. Furthermore, in these cases this is a specific sign which may enable differentiation of bone crises from other types of bone pain associated with Gaucher's disease.
Horev
G
G
Department of Pediatric Radiology, Beilinson Medical Center, School of Medicine, TA University, Petach-Tikva, Israel.
Kornreich
L
L
Hadar
H
H
Katz
K
K
D000293:Adolescent; D001847:Bone Diseases / Q000175:diagnosis*; D002648:Child; D005260:Female; D005269:Femur / Q000473:pathology; D005776:Gaucher Disease / Q000150:complications* / Q000473:pathology; D006470:Hemorrhage / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013977:Tibia / Q000473:pathology