[Phosphorus-calcium metabolism in children under prolonged treatment with anticonvulsants. (II)].
Comparative assessments were made regarding the effects of prolonged administration of anticonvulsant drugs (phenobarbital, carbamazepine, valproate and polytherapy) on the different biochemical parameters related to phosphocalcium metabolism, in 98 children between 1 and 14 years. The most patent effect was on the levels of 25-Hydroxycholecalciferol which went down significantly (p = 0.0001) in children treated with phenobarbital (34.5 +/- 17 ng/ml) or polytherapy (28.4 +/- 18 ng/ml) in relation to those treated with carbamazepine (49.2 +/- 15 ng/ml) or valproate (43.1 +/- 15 ng/ml) and to control group (45.9 +/- 13 ng/ml). The alkaline phosphatase has been found significantly higher among those treated with phenobarbital, carbamazepine and polytherapy, evidencing significant differences in relation to those treated with valproate and to control group (p less than 0.05). For calcium, parathyroid hormone and osteocalcine levels no differences were found in the different drugs, nor with control group. Depending on the duration of treatment there was a significant reduction (p = 0.02) in the levels of 25-Hydroxycholecalciferol in children treated over 3 years, but no difference for calcium, phosphorous, alkaline phosphatase and PTH under this parameter.
Peña Griñán
M J
MJ
Departamento de Pediatría, Hospital Universitario Virgen Macarena, Sevilla.
Lluch Fernández
M D
MD
Montoya García
M J
MJ
Ramos Sánchez
I
I
Pérez Cano
R
R
D000927:Anticonvulsants / Q000008:administration & dosage* / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism*; D002220:Carbamazepine / Q000008:administration & dosage / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology; D010758:Phosphorus / Q000378:metabolism*; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology
D000927:Anticonvulsants; D010758:Phosphorus; D002220:Carbamazepine; D014635:Valproic Acid; D002118:Calcium; D010634:Phenobarbital
Metabolismo fosfocálcico en niños con tratamiento prolongado anticonvulsivo. (II).