Occupational asthma to spores of Pleurotus cornucopiae.
We report the case of a young man who developed severe asthma a few months after starting work in a factory producing a single type of mushroom: Pleurotus cornucopiae (a basidiomycete). Immunological investigations, performed with material recovered from the filtering devices of the mushroom's bed, led to demonstration of specific IgE and IgG against spore extracts and to isolation of one discriminant antigen (molecular weight: 10.5 kd). Current data concerning the underestimated role of the basidiomycetes in allergic asthma are reviewed.
Michils
A
A
Dept of Pneumology, Erasme Hospital, University of Brussels, Belgium.
De Vuyst
P
P
Nolard
N
N
Servais
G
G
Duchateau
J
J
Yernault
J C
JC
D000328:Adult; D000908:Antibodies, Fungal / Q000276:immunology*; D000946:Antigens, Fungal / Q000302:isolation & purification*; D001249:Asthma / Q000276:immunology / Q000382:microbiology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015151:Immunoblotting; D008297:Male; D009784:Occupational Diseases / Q000276:immunology / Q000382:microbiology*; D016273:Occupational Exposure; D011124:Polyporaceae / Q000276:immunology*; D011852:Radioallergosorbent Test; D013172:Spores, Fungal
D000908:Antibodies, Fungal; D000946:Antigens, Fungal