Insulinlike effects of sodium selenate in streptozocin-induced diabetic rats.
Treatment of streptozocin (STZ)-induced diabetic rats with sodium selenate (10-15 mumol.kg-1.day-1) for 7 wk resulted in a decrease in plasma glucose, food intake, and water intake to control or near control levels. Plasma insulin was reduced in control rats given sodium selenate to the level found in the diabetic and treated diabetic group. Treatment did not affect control rats with regard to the other measurements cited. Sodium selenate enhanced weight gain in responding diabetic rats to that seen in controls; sodium selenate's actions thus resembled those of insulin. Thus selenate, like vanadium, appears to have insulinlike effects when administered in vivo.
McNeill
J H
JH
Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Delgatty
H L
HL
Battell
M L
ML
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004435:Eating; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D064586:Selenic Acid; D012643:Selenium / Q000627:therapeutic use*; D018036:Selenium Compounds
D001786:Blood Glucose; D007328:Insulin; D018036:Selenium Compounds; D012643:Selenium; D064586:Selenic Acid