[The content of cyclic nucleotides, free cytoplasmic Ca2+ and malondialdehyde in the splenic lymphocytes and thymocytes of rats under the action of moderate doses of radiation].
It has been shown that the malonic dialdehyde (MDA) content in spleen lymphocytes of rats increases after whole-body X irradiation with a dose of 0.5 Gy to reach the maximum level in 24 h. Simultaneously, the concentration of cGMP and free cytosol Ca2+ increases. With a dose of 1 Gy MDA content of cells increases 6 h following irradiation. The maximum drop of the release of viable lymphocytes from the spleen and thymus, observed 24 h and 3 days after irradiation respectively, coincides with the appearance of the second peak of the MDA content. The level of cGMP remains decreased throughout the period of about 6 days. The onset of lymphocyte repopulation in the spleen on day 6 coincides with the decrease in the MDA level and increase in the cytosol Ca2+ concentration.
Kucherenko
N E
NE
Matyshevskaia
O P
OP
Ostapchenko
L I
LI
Parkhomets
T I
TI
Ruchko
M V
MV
Slatvinskaia
E A
EA
D000818:Animals; D002118:Calcium / Q000032:analysis / Q000528:radiation effects*; D003593:Cytoplasm / Q000737:chemistry / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D008214:Lymphocytes / Q000737:chemistry / Q000528:radiation effects*; D008315:Malondialdehyde / Q000032:analysis / Q000528:radiation effects*; D009712:Nucleotides, Cyclic / Q000032:analysis / Q000528:radiation effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000737:chemistry / Q000528:radiation effects*; D013950:Thymus Gland / Q000737:chemistry / Q000528:radiation effects*; D013997:Time Factors
D009712:Nucleotides, Cyclic; D008315:Malondialdehyde; D002118:Calcium
Soderzhanie tsiklicheskikh nukleotidov, svobodnogo tsitoplazmaticheskogo Ca2+ i malonovogo dial'degida v limfotsitakh selezenki i timotsitakh krys pri deĭstvii nevysokikh doz radiatsii.