title: Racial differences in the frequencies of scleroderma-related autoantibodies.
abstract: OBJECTIVE
  To determine demographic differences in scleroderma-related autoantibodies.
  
  
  METHODS
  One hundred fifty-six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti-topoisomerase I (anti-topo I, or Scl-70), antinucleolar, and anti-U1 RNP autoantibodies.
  
  
  RESULTS
  ACA was found in 36% of Caucasians and 4% of American blacks (P = 0.002, odds ratio [OR] 15). Anti-topo I was found in 37% of American blacks, compared with 17% of Caucasians (P = 0.04, OR 3). No significant differences in the frequencies of antinucleolar and anti-U1 RNP autoantibodies were found.
  
  
  CONCLUSIONS
  These data suggest important demographic differences in scleroderma-associated autoantibodies.
authors.affiliation: Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center, Houston.
authors.forename: J D
authors.initials: JD
authors.lastname: Reveille
authors.forename: E
authors.initials: E
authors.lastname: Durban
authors.forename: R
authors.initials: R
authors.lastname: Goldstein
authors.forename: R
authors.initials: R
authors.lastname: Moreda
authors.forename: F C
authors.initials: FC
authors.lastname: Arnett
mesh_terms: D001323:Autoantibodies / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D006630:Hispanic or Latino; D006801:Humans; D009687:Nuclear Proteins / Q000276:immunology; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000208:ethnology* / Q000276:immunology*; D044465:White People / Q000235:genetics*
chemical_list: D001323:Autoantibodies; D009687:Nuclear Proteins