Acute monoblastic leukemia (FAB-M5b) with t(8;14)(p11;q11.1).
A case of acute monocytic leukemia (FAB-M5b) expressing natural killer cell-associated antigens containing a t(8;14)(p11;q11.1) is presented. We interpret this translocation to represent a variant of the t(8;16) previously reported in FAB-M5b. These findings support the contention that the 8p11 breakpoint site is the critical junction in the oncogenesis of acute monoblastic leukemia with differentiation.
Slovak
M L
ML
Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA.
Nemana
L
L
Traweek
S T
ST
Stroh
J A
JA
D000368:Aged; D000369:Aged, 80 and over; D002883:Chromosomes, Human, Pair 14; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic