title: [Antimicrobial activity of piperacillin in vitro].
abstract: There was an increase in the resistance of clinical isolates to piperacillin as compared to that in 1987-1988. It was shown on the kinetic models that there was difference in the effect of the inhibitory and subinhibitory concentrations of the drug on microorganisms in various growth phases. No post-antibiotic action against Staphylococcus aureus and Pseudomonas aeruginosa and a slightly pronounced dose-dependent effect with respect to Escherichia coli were noted.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Skala
authors.forename: A G
authors.initials: AG
authors.lastname: Nekhorosheva
authors.forename: V N
authors.initials: VN
authors.lastname: Nasonov
authors.forename: V A
authors.initials: VA
authors.lastname: Prokhorova
mesh_terms: D003470:Culture Media; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects*
chemical_list: D003470:Culture Media; D010878:Piperacillin
vernacular_title: Antimikrobnaia aktivnost' piperatsillina in vitro.