[Adrenocortical nodular hyperplasia as a cause of Cushing syndrome in the neonatal period].
The case report of a female child born preterm (30th wk of gestation) who developed symptoms of Cushing's syndrome beginning in the neonatal phase is presented. The disease was caused by a unilateral adreno-cortical nodular hyperplasia and was successfully treated by unilateral adrenalectomy. Preoperative treatment with ketoconazole and metyrapone proved to be effective. Symptoms of Cushing's disease including hypertrophic cardiomyopathy were completely reversible within one month after surgery.
Gessler
P
P
Abteilung Kinderheilkunde II, Universität Tübingen.
Ranke
M B
MB
Wollmann
H
H
Aicher
K P
KP
Feine
U
U
Kaiserling
E
E
Leriche
C
C
Steil
E
E
D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D003480:Cushing Syndrome / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D007654:Ketoconazole / Q000008:administration & dosage; D008797:Metyrapone / Q000008:administration & dosage; D011300:Preoperative Care
D007654:Ketoconazole; D008797:Metyrapone
Adreno-corticale noduläre Hyperplasie als Ursache eines Cushing-Syndroms in der Neugeborenenperiode.