title: Site of action of hypertonic saline in the canine lung.
abstract: The site of action of inhaled hypertonic saline was determined in 8- to 10-wk-old puppies by combining measurements of respiratory mechanics, made during mechanical ventilation and after midexpiratory flow interruptions, with direct measurements of alveolar pressure. Under both control conditions and after inhalation of 10% saline, we were able to partition lung mechanics into components representing the airways and tissue viscoelastic properties. Hypertonic saline challenge altered lung mechanics by increasing airway resistance and did not have any effect on elastic or viscoelastic properties of the lung.
authors.affiliation: Clinical Sciences Division, Western Australian Research Institute for Child Health, Perth.
authors.forename: P D
authors.initials: PD
authors.lastname: Sly
authors.forename: C J
authors.initials: CJ
authors.lastname: Lanteri
mesh_terms: D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D004548:Elasticity; D008168:Lung / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000502:physiology; D012121:Respiration, Artificial; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics / Q000187:drug effects; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D014783:Viscosity
chemical_list: D012462:Saline Solution, Hypertonic; D000420:Albuterol