Abnormal renal hemodynamics in black salt-sensitive patients with hypertension.
African-Americans with essential hypertension are more prone to the development of renal failure and are frequently salt-sensitive as well. Because alterations of intrarenal hemodynamics are important in the progression of renal disease and because salt-sensitive animal models with hypertension manifest a greater propensity to develop glomerulosclerosis in association with a rise in glomerular capillary pressure, we tested whether the renal hemodynamic adaptation to high dietary Na+ intake differs in salt-sensitive and salt-resistant hypertensive patients. We studied 17 black and nine white patients with essential hypertension who were placed on a low Na+ diet (20 meq/day) for 9 days, followed by a high Na+ diet (200 meq/day) for 14 days. During the last 4 days of each diet regimen, they received 30 mg/day of slow-release nifedipine. Eleven blacks were salt-sensitive, and all whites were salt-resistant. During the low Na+ diet period, salt-sensitive and salt-resistant patients had similar mean arterial pressure, glomerular filtration rate, effective renal plasma flow, and filtration fraction.(ABSTRACT TRUNCATED AT 250 WORDS)
Campese
V M
VM
Department of Medicine, University of Southern California Medical Center, Los Angeles 90033.
Parise
M
M
Karubian
F
F
Bigazzi
R
R
D000704:Analysis of Variance; D044383:Black People; D001794:Blood Pressure / Q000187:drug effects; D005919:Glomerular Filtration Rate; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000178:diet therapy / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply*; D009543:Nifedipine / Q000494:pharmacology; D012982:Sodium, Dietary / Q000494:pharmacology*; D014481:United States; D014655:Vascular Resistance / Q000187:drug effects; D044465:White People; D001741:Black or African American
D012982:Sodium, Dietary; D009543:Nifedipine