Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man.
Buspirone, a putative serotonin (5-HT)1A partial agonist, did not produce hypothermia in 17 normal volunteers in a placebo controlled, single blind study. Thus, buspirone may be a weaker agonist at those 5-HT1A receptors which mediate hypothermia compared to ipsapirone or gepirone, two other 5-HT1A partial agonists which have been reported to produce hypothermia by a 5-HT1A-mediated mechanism.
Lee
H S
HS
Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, Ohio.
Meltzer
H Y
HY
D000328:Adult; D001831:Body Temperature / Q000187:drug effects*; D002065:Buspirone / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D008297:Male; D012701:Serotonin / Q000502:physiology*; D016037:Single-Blind Method
D012701:Serotonin; D002065:Buspirone