title: Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line.
abstract: Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.
authors.affiliation: Department of Urology, Yokohama City University, School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Shuin
authors.forename: E
authors.initials: E
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Yoshioka
mesh_terms: D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D003470:Culture Media; D004790:Enzyme Induction; D015870:Gene Expression / Q000187:drug effects; D016259:Genes, myc / Q000187:drug effects*; D006801:Humans; D007680:Kidney Neoplasms; D007700:Kinetics; D008081:Liposomes; D010716:Phosphatidylinositols / Q000494:pharmacology*; D011493:Protein Kinase C / Q000096:biosynthesis / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms
chemical_list: D003470:Culture Media; D008081:Liposomes; D010716:Phosphatidylinositols; D011493:Protein Kinase C; D002118:Calcium