title: Shear stress related blood damage along the cusp of a tri-leaflet prosthetic valve.
abstract: Blood flowing through a prosthetic heart valve can be damaged by flow-induced shear forces. Fluid dynamics variables and geometric factors play an important role in the evaluation of shear-stress-related blood damage. Central-flow prosthetic valves have been considered as an optimal replacement for mechanical and biological valves. Recently it was shown that shear stress distribution along the surface of a polyurethane cusp reaches values that can damage the blood elements. A mathematical model correlating the effects of shear stresses on blood corpuscles with clinical findings was employed in vitro. The model can be applied to the effects of blood-surface interaction and is of clinical relevance.
authors.affiliation: Biomedical Engineering Program, Tel Aviv University, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Einav
authors.forename: H
authors.initials: H
authors.lastname: Reul
authors.forename: G
authors.initials: G
authors.lastname: Rau
authors.forename: D
authors.initials: D
authors.lastname: Elad
mesh_terms: D001773:Blood Cells / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology; D006350:Heart Valve Prosthesis; D006801:Humans; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D011140:Polyurethanes; D011474:Prosthesis Design; D013314:Stress, Mechanical
chemical_list: D011140:Polyurethanes