Inhibitory effects of endothelin-1 and endothelin-3 on prolactin release: possible involvement of endogenous endothelin isopeptides in the rat anterior pituitary.
Spontaneous prolactin release from the isolated rat anterior pituitary was inhibited by endothelin-1 in a dose-dependent manner (10(-8)-10(-6) M). Endothelin-3 also inhibited spontaneous prolactin release with an almost identical dose-response relationship as endothelin-1. These inhibitory effects were unaffected by application of a dopamine D2-receptor antagonist, YM-09151-2 (10(-7) M). Rat anterior and posterior pituitary glands were abundant in both endothelin-1 and endothelin-3, as compared with other regions of the brain. The present results suggest that endogenous endothelin-1 and endothelin-3 in the anterior and posterior pituitary are involved in the inhibitory regulation of prolactin secretion as autocrine or paracrine factors.
Domae
M
M
Department of Pharmacology, School of Medicine, Fukuoka University, Japan.
Yamada
K
K
Hanabusa
Y
Y
Furukawa
T
T
D000704:Analysis of Variance; D000818:Animals; D001923:Brain Chemistry; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000032:analysis / Q000494:pharmacology* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D010903:Pituitary Gland, Anterior / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D016232:Endothelins; D011388:Prolactin