Lasting impact of a single benzpyrene treatment in pre-natal and growing age on the thymic glucocorticoid receptors of rats.
1. Rats exposed to benzpyrene in utero at 19 days of pre-natal life showed a relative decrease in the number of thymic glucocorticoid receptors at 6 weeks of age. 2. Primary exposure to benzpyrene at 6 weeks of age had a similar effect on females 4 weeks later, but did not change the glucocorticoid receptor number of males. 3. In utero exposure accounted for an increase in the fetal cytochrome P450 level within 1 day, whereas exposure at 6 weeks of age did not change it within 4 weeks. 4. It appears that exposure to benzpyrene gives rise to a faulty imprinting of the thymic glucocorticoid receptor in both fetal and growing age, to judge from a lasting change in the receptor number.
Csaba
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G
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
Inczefi-Gonda
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A
Szeberényi
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S
D000375:Aging / Q000502:physiology*; D000818:Animals; D001564:Benzo(a)pyrene / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D012727:Sex Characteristics; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D001564:Benzo(a)pyrene; D003907:Dexamethasone; D003577:Cytochrome P-450 Enzyme System