Neutralizing antibody responses in patients with AIDS with neurologic complications.
Although the human immunodeficiency virus type 1 (HIV-1) is frequently isolated from the cerebrospinal fluid of infected patients, only a small percentage of patients are found to have clinical dementia or neuropathies (or both). The reasons for this remain unclear. In our study, serum neutralizing antibody titers against the human T cell leukemia virus-IIIB isolate of HIV-1 were tested in 10 patients with acquired immunodeficiency syndrome (AIDS) with neurologic complications and 20 patients with HIV infection without neurologic complications. Titers were significantly lower in the neuro-AIDS group, suggesting that impaired neutralizing antibody responses in this subpopulation of patients may be involved in the immunopathogenesis of AIDS encephalopathy.
Beilke
M A
MA
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.
Minagawa
H
H
Stone
G
G
Leon-Monzon
M
M
Gibbs
C J
CJ
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000382:microbiology; D015483:HIV Antibodies / Q000276:immunology*; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000145:classification / Q000276:immunology*; D006467:Hemophilia A / Q000150:complications; D006801:Humans; D008264:Macrophages / Q000382:microbiology; D009500:Neutralization Tests
D015483:HIV Antibodies; D015699:HIV Envelope Protein gp120