The effect of acetazolamide on the endolymphatic sac DC potential.
The effect of acetazolamide known as a potent carbonic anhydrase inhibitor of the endolymphatic sac DC potential (ESP) was examined in the guinea pig. Intravenous administration of acetazolamide produced a dose-dependent decrease in ESP amplitude at doses of less than 10 mg/kg. The effect of acetazolamide on ESP was saturated at doses exceeding 10 mg/kg. The maximum reduction of ESP induced by acetazolamide was approximately 50% of the original ESP amplitude. The results suggest that carbonic anhydrase is involved in the generation of ESP.
Uozumi
N
N
Department of Otolaryngology, Kagawa Medical School, Japan.
Mori
N
N
Sakai
S
S
D000086:Acetazolamide / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004712:Endolymphatic Sac / Q000187:drug effects / Q000503:physiopathology*; D006168:Guinea Pigs; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D010101:Oxygen Consumption
D000086:Acetazolamide