title: Marine bioactive compounds: stereospecific anti-inflammatory activity of natural and synthetic cordiachromene A.
abstract: A new synthesis is proposed for cordiachromene A (CCA), a bioactive component of the ascidian Aplidium antillense Gravier, using a method producing a racemic mixture. The anti-inflammatory activities of a natural extract and a chemically synthetic form of CCA were assessed in vivo by carrageenan-induced rat-paw edema. The activity of synthetic CCA was confirmed by a test on kaolin-induced granuloma in the rat. Strong activities were measured for both CCA, but comparison of results of the first test suggests that only the natural optically active isomer has an anti-inflammatory effect. CCA is similar to indomethacin in its effect on carrageenan-induced rat-paw edema and ten times as active as phenylbutazone.
authors.affiliation: Faculty of Pharmacy Research Group "Substances Marines a Achivité Biologique", University of Nantes, France.
authors.forename: A F
authors.initials: AF
authors.lastname: Benslimane
authors.forename: Y F
authors.initials: YF
authors.lastname: Pouchus
authors.forename: J F
authors.initials: JF
authors.lastname: Verbist
authors.forename: J Y
authors.initials: JY
authors.lastname: Petit
authors.forename: E N
authors.initials: EN
authors.lastname: Khettab
authors.forename: L
authors.initials: L
authors.lastname: Welin
authors.forename: J D
authors.initials: JD
authors.lastname: Brion
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002351:Carrageenan; D002867:Chromones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005534:Foot Diseases / Q000139:chemically induced / Q000517:prevention & control; D006099:Granuloma / Q000209:etiology / Q000517:prevention & control; D007536:Isomerism; D007616:Kaolin; D008297:Male; D051379:Mice; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D007616:Kaolin; C042676:2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-6-ol; D002351:Carrageenan