Liver response to low-hexachlorobenzene exposure in protein- or energy-restricted rats.
The individual effects of protein deficiency and energy restriction on liver response to low-hexachlorobenzene (HCB) exposure were investigated in adult male Wistar rats. In rats fed either the low-protein or control diet, the only effect caused by HCB was a decrease in paralysis time following an ip injection of zoxazolamine. This decrease was similar for both groups. In the animals subjected to energy restriction, HCB induced a greater decrease in paralysis time, an increase in the size of centrilobular hepatocytes, a lower liver DNA content and an increased concentration of HCB in the adipose tissue, compared with the control and protein-deficient groups. Our data suggest that energy restriction increases liver response to HCB, while protein deficiency does not impair the hepatic reaction to small doses of HCB exposure.
Rodrigues
M A
MA
Department of Pathology, Botacatu Medical School, UNESP, SP, Brazil.
Sanchez-Negrette
M
M
Mantovani
M S
MS
Sant'ana
L S
LS
Angeleli
A Y
AY
Montenegro
M R
MR
de Camargo
J L
JL
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004044:Dietary Proteins / Q000008:administration & dosage*; D002149:Energy Intake; D006581:Hexachlorobenzene / Q000493:pharmacokinetics / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010243:Paralysis / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D004044:Dietary Proteins; D006581:Hexachlorobenzene