Solitary myeloma with massive extracellular crystalline structures--a case report.
We describe a case of solitary myeloma showing cystic change filled with massive crystalline structures in a 54-year-old woman. A bone X-ray showed a solitary cystic osteolytic lesion in the right iliac bone. Serum and urine protein electrophoresis showed no demonstrable M-protein, and bone-marrow aspirates did not show any myeloma cells. Histologic examination of the tumor revealed aggregation of plasma cells with massive extracellular infiltration of the rhomboid-shaped crystalline structures. In immunoperoxidase staining, both these crystalline structures and the cytoplasms of the myeloma cells demonstrated a positive reaction for lambda light chain. By electron microscope, the large extracellular crystalline structures were observed, and we found unique rhomboid or rectangular-shaped crystalline structures in the cytoplasms of the myeloma cells.
Kim
Y G
YG
Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.
Yang
K H
KH
Gang
S J
SJ
Kim
B K
BK
Kim
S M
SM
D001859:Bone Neoplasms / Q000276:immunology / Q000648:ultrastructure*; D003460:Crystallization; D005110:Extracellular Space / Q000276:immunology; D005260:Female; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D010954:Plasmacytoma / Q000276:immunology / Q000648:ultrastructure*
D007146:Immunoglobulin lambda-Chains