title: Caries susceptibility in inbred mouse strains and inheritance patterns in F1 and backcross (N2) progeny from strains with high and low caries susceptibility.
abstract: We studied dental caries susceptibility in various inbred mice strains infected with Streptococcus mutans and the inheritance pattern in the F1 and the N2 backcross animals. A high caries score was observed in four laboratory strains, BALB/cAJcl, C57BL/6NJcl, C57BL/10Slc and DBA/2NJcl. Three strains, C3H/HeNJcl, AKR/JSlc and CBA/JNCrj, showed less caries. Males of strain C57BL/10Slc (mean caries score = 112.2) and females of strain C3H/HeNJcl (mean caries score = 24.0) were chosen for examinations of the inheritance of the caries susceptibility. The mean caries score in (C57BL/10Slc x C3H/HeNJcl) F1 hybrids was 98.4, demonstrating that F1 progenies were susceptible. A number of N2 mice were obtained by mating the F1 male and the C3H/HeNJcl female. The caries scores of these N2 male mice had an extensive range, from 14 to 194. Assuming that a caries score over 74 (median of the scores between C57BL/10Slc and C3H/HeNJcl) belonged to the highly caries-susceptible group, N2 mice could be divided into groups with low or high caries susceptibility. Furthermore, the effect of nu/nu mutation on caries susceptibility in mice was also examined.
authors.affiliation: Department of Pedodontics, Nihon University School of Dentistry, Matsudo, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kurihara
authors.forename: T
authors.initials: T
authors.lastname: Naito
authors.forename: K
authors.initials: K
authors.lastname: Obayashi
authors.forename: M
authors.initials: M
authors.lastname: Hirasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kurihara
authors.forename: K
authors.initials: K
authors.lastname: Moriwaki
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003433:Crosses, Genetic; D003733:Dental Caries Susceptibility / Q000235:genetics* / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008819:Mice, Nude / Q000235:genetics; D009154:Mutation; D013295:Streptococcus mutans / Q000472:pathogenicity; D013601:T-Lymphocytes