[Changes in respiratory resistance and dynamic compliance induced by histamine in the guinea pig].
Respiratory resistance and dynamic compliance in guinea pigs were measured by pulmonary mechanics analyzer Buxco Model 6. Changes induced by intravenous injection of histamine were studied. Administration of histamine caused dose-dependent increase in respiratory resistance and decrease in dynamic compliance in guinea pigs. The increase in respiratory resistance by repeated injections of the same dose of histamine was maintained at the same level 5 hours after the first injection. However, the decrease in dynamic compliance by histamine administration decreased significantly from 1 to 4 hours after the first injection. The baseline resistance increased from 1 to 5 hours after the first injection of histamine. The baseline compliance decreased from 1 to 5 hours after the first injection.
Aoki
S
S
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Tsukagoshi
H
H
Kurosawa
M
M
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001249:Asthma / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008170:Lung Compliance / Q000187:drug effects*; D008297:Male; D012119:Respiration / Q000187:drug effects
D006632:Histamine