title: Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Dwyer
authors.forename: T C
authors.initials: TC
authors.lastname: Hamilton
authors.forename: R C
authors.initials: RC
authors.lastname: Young
authors.forename: F P
authors.initials: FP
authors.lastname: LaCreta
authors.forename: N
authors.initials: N
authors.lastname: Carp
authors.forename: K D
authors.initials: KD
authors.lastname: Tew
authors.forename: K
authors.initials: K
authors.lastname: Padavic
authors.forename: R L
authors.initials: RL
authors.lastname: Comis
authors.forename: R F
authors.initials: RF
authors.lastname: Ozols
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019328:Buthionine Sulfoximine; D005260:Female; D005978:Glutathione / Q000187:drug effects*; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008717:Methionine Sulfoximine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000964:Antimetabolites, Antineoplastic; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D008558:Melphalan