Blood compatibility of the jellyfish valve without anticoagulant.
The blood compatibility of the jellyfish valve was studied. Artificial heart (AH) blood pumps incorporating jellyfish valves were connected to 18 goats as total artificial hearts (TAHs) and pumped for 1 to 125 days without anticoagulant or antiplatelet drugs. No thrombus was formed on the valve membrane or around the valve seat. Scanning electron microscopy showed almost no platelet deposition or microfibrin clot formation on the valve membrane, including its central region; the spokes of the valve seat were also free from platelet and microfibrin clots. No calcification was observed during these tests, and plasma free hemoglobin was between 2 and 7 mg/dl. The jellyfish valve revealed good blood compatibility, even without anticoagulant use.
Imachi
K
K
Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.
Mabuchi
K
K
Chinzei
T
T
Abe
Y
Y
Imanishi
K
K
Suzukawa
M
M
Yonezawa
T
T
Kouno
A
A
Ono
T
T
Nozawa
H
H
D000818:Animals; D006041:Goats; D006350:Heart Valve Prosthesis; D006354:Heart, Artificial; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011474:Prosthesis Design; D013499:Surface Properties; D013927:Thrombosis / Q000473:pathology*