Reversible renal failure following opioid administration.
A patient who received intravenous papaveretum during and after operation developed anuria and biochemical evidence of impaired renal function in the first 6 hours after surgery. Administration of naloxone 0.4 mg was associated with a sustained improvement in urine output. Mean arterial pressure did not change significantly. The impairment of renal function may have been related to high plasma concentrations of codeine, one of the constituents of papaveretum.
Hill
S A
SA
Department of Anaesthesia, Addenbrooke's Hospital, Cambridge.
Quinn
K
K
Shelly
M P
MP
Park
G R
GR
D058186:Acute Kidney Injury / Q000097:blood / Q000139:chemically induced* / Q000652:urine; D003061:Codeine / Q000097:blood / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000097:blood / Q000652:urine; D009892:Opium / Q000009:adverse effects*; D010149:Postoperative Pain / Q000517:prevention & control; D011183:Postoperative Complications / Q000139:chemically induced*
D009020:Morphine; D009892:Opium; D003061:Codeine