title: Role of histaminergic mechanisms in the regulation of some stress responses in rats.
abstract: The involvement of histaminergic mechanisms in the regulation of some stress responses was studied in rats. The brain neuronal histamine (HA) depletor, alpha-fluoromethyl histidine (alpha-FMH), at doses (50 or 100 mg/kg) which markedly lower brain HA, significantly attenuated the gastric ulcer formation and the elevation in plasma corticosterone in response to cold restraint stress (CRS). alpha-FMH also appreciably reduced gastric mucosal HA content. The H1-antagonist, pheniramine (25 mg/kg), attenuated both the gastric mucosal and endocrine response to CRS, while the effects of the H2-antagonist, cimetidine (200 mg/kg), were on the plasma corticosterone levels. These results are discussed in light of complex HA-ergic mechanisms in the maintenance of physiological homeostasis during stress.
authors.affiliation: Department of Pharmacology, University College of Medical Sciences, Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Puri
authors.forename: A
authors.initials: A
authors.lastname: Ray
authors.forename: A K
authors.initials: AK
authors.lastname: Chakravarty
authors.forename: P
authors.initials: P
authors.lastname: Sen
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology; D003080:Cold Temperature; D003345:Corticosterone / Q000097:blood; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006632:Histamine / Q000378:metabolism / Q000502:physiology*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors; D006706:Homeostasis / Q000187:drug effects; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology; D009411:Nerve Endings / Q000187:drug effects / Q000378:metabolism; D010632:Pheniramine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000503:physiopathology / Q000517:prevention & control; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D000897:Anti-Ulcer Agents; D008762:Methylhistidines; D010632:Pheniramine; C028309:alpha-fluoromethylhistidine; D002927:Cimetidine; D006632:Histamine; D006640:Histidine Decarboxylase; D003345:Corticosterone