The effects of clonazepam on rolandic discharge of benign epilepsy of children with centro-temporal EEG foci.
1) CZP had marked effects on RD. RD disappeared in 8 (73%) of 11 patients treated with CZP alone and 6 (43%) of 14 treated with CZP in combination with other drugs. Even when RD persisted, its amplitude and frequency decreased in some patients. 2) In the group treated with CZP in combination with other drugs, RD disappeared in all 5 patients with the persistent RD, of whom 2 had arachnoid cyst. Of the 6 patients with frequent seizures, 2 were subsequently diagnosed as having CPS and SPS, respectively. Patients who did not respond to CPZ included those in whom the diagnosis of BECCT should be reconfirmed, and electro-clinical response may be also useful for diagnosing RD. 3) In patients treated with CZP alone for a short-term treatment of BECCT, the drug administration could be discontinued only in one. A longer follow-up study is necessary to reach a conclusion in future.
Takahashi
K
K
Department of Pediatrics, Juntendo University, Tokyo, Japan.
Saito
M
M
Kyo
K
K
Gomibuchi
K
K
Niijima
S
S
Tada
H
H
Honda
T
T
Sato
Y
Y
Takahashi
H
H
Ohtsuka
C
C
D000293:Adolescent; D002220:Carbamazepine / Q000627:therapeutic use; D002648:Child; D002998:Clonazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects*; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000503:physiopathology; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013702:Temporal Lobe / Q000187:drug effects / Q000503:physiopathology; D014635:Valproic Acid / Q000627:therapeutic use
D002220:Carbamazepine; D002998:Clonazepam; D014635:Valproic Acid