title: [The role of gastroesophageal reflux in the hemorrhaging of esophageal varices. Effect of endoscopic sclerotherapy].
abstract: From January 1st to December 31st 1987, 51 prospectively selected patients underwent 24-hour intraesophageal pH monitoring before, and 5 weeks after endoscopic paravariceal sclerotherapy (ESCL). Patients were divided into two groups: in group I. first pH monitoring was done 24 hours after acute variceal bleeding; in group II. one month after a previous bleeding episode. Gastroesophageal reflux (GER) was expressed by percentage of time below pH 4, and by average number of reflux episodes, lasting longer than 5 seconds, per hour. In group I. the time below pH 4 (10.3 +/- 2.05%) and the number of reflux episodes (24.4 +/- 4.2/h) were significantly higher, than those in group II. (2.57 +/- 0.14%; 2.39 +/- 0.31/h). Pathologic GER parameters were significantly more frequent in group I. (50% and 73%), than in group II. (16.7% and 29.1%). ESCL significantly reduced GER in both groups of patients. In group I. GER remained pathologic at 12.5% and 20.8% of patients. In group II. time below pH 4 became normal at all of the patients, and only one of them has pathologic number of reflux episodes. Our data give evidence of GER having a possible causative role in initiating variceal bleeding. ESCL significantly reduces GER. This effect might contribute to long term results of ESCL.
authors.affiliation: Semmelweis Orvostudományi Egyetem, Budapest, I. Sebészeti Klinika.
authors.forename: P
authors.initials: P
authors.lastname: Kupcsulik
authors.forename: A
authors.initials: A
authors.lastname: Forgács
authors.forename: N
authors.initials: N
authors.lastname: Csoszánszky
mesh_terms: D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000188:drug therapy / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy* / Q000209:etiology; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012597:Sclerosing Solutions / Q000627:therapeutic use*
chemical_list: D012597:Sclerosing Solutions
vernacular_title: A gastrooesophagealis reflux szerepe a nyelöcsövarix-vérzésben. Az endoscopos scleroterápia refluxcsökkentö hatása.