title: Respiratory mechanics of the piglet during the first month of life.
abstract: Piglets at 3, 14, and 30 days of age were studied to assess the postnatal changes in lung, chestwall, and total respiratory system compliance associated with normal growth. Static deflation compliance of the lung and total respiratory system increased significantly with age; there was no change in chestwall compliance. When normalized for body weight or lung volume, all measures of compliance tended to decrease with postnatal age. Measures of lung and chestwall compliance obtained with an end-inspiratory occlusion technique were less than the static compliance measures, but demonstrated the same relative changes with postnatal maturation. Chestwall compliance at 3 days of age was only 1.3 times greater than lung compliance and there was no significant change in this ratio with postnatal age. In contrast to the trend for the human infant, the piglet's chestwall at 3 days of age is stiff relative to the lung and does not become stiffer with age over the first 4 weeks of life.
authors.affiliation: Department of Pediatrics, University of Washington, Seattle 98195.
authors.forename: T A
authors.initials: TA
authors.lastname: Standaert
authors.forename: B E
authors.initials: BE
authors.lastname: Wilham
authors.forename: D E
authors.initials: DE
authors.lastname: Mayock
authors.forename: J F
authors.initials: JF
authors.lastname: Watchko
authors.forename: R L
authors.initials: RL
authors.lastname: Gibson
authors.forename: D E
authors.initials: DE
authors.lastname: Woodrum
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology; D008170:Lung Compliance / Q000502:physiology; D008176:Lung Volume Measurements; D015656:Respiratory Mechanics / Q000502:physiology*; D013552:Swine / Q000254:growth & development*