title: Prevention of endotoxin-induced increase of cerebral oxygen consumption in dogs by propranolol pretreatment.
abstract: Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) were studied in experimental endotoxic shock in dogs. Eight animals were pretreated with a beta-adrenoceptor blocking agent, propranolol (PPL), per os 12 mg/kg once a day for 7 days. Ten animals served as controls. After an intravenous injection of endotoxin, 1 mg/kg, CBF decreased in both groups, with no significant differences between the groups. CMRO2 increased in the control animals by about 18% from the baseline value both 1 and 2 h after the injection of endotoxin. CMRO2 in the PPL-pretreated animals was unchanged after endotoxin. The CMRO2-reactions to endotoxin in control and PPL animals were significantly different after both 1 and 2 h (P less than 0.05). The present results indicate that the increase in CMRO2 following intravenous endotoxin is mediated via beta-adrenoceptors.
authors.affiliation: Department of Anaesthesiology, Sahlgren's Hospital, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Westerlind
authors.forename: L E
authors.initials: LE
authors.lastname: Larsson
authors.forename: J
authors.initials: J
authors.lastname: Häggendal
authors.forename: B
authors.initials: B
authors.lastname: Ekström-Jodal
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004285:Dogs; D004731:Endotoxins / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D004926:Escherichia coli; D006339:Heart Rate / Q000187:drug effects; D008070:Lipopolysaccharides; D009638:Norepinephrine / Q000097:blood / Q000134:cerebrospinal fluid; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects*; D011433:Propranolol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D004731:Endotoxins; D008070:Lipopolysaccharides; D011433:Propranolol; D010100:Oxygen; D009638:Norepinephrine; D004837:Epinephrine