title: Nonrandom CpG mutations affect the synonymous codon usage of moderately GC-rich single copy actin genes.
abstract: In species where actin genes exist as single copies, analysis of their synonymous codon usage and of the substitutions occurring between the genes of closely related species shows that there is a positive selection for codons that do not have highly mutable CpG dinucleotides in codon positions 2 and 3 when the GC content of these genes is less than 57%.
authors.affiliation: Department of Biology, University of Ottawa, Ontario, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Drouin
mesh_terms: D044503:5-Methylcytosine; D000199:Actins / Q000235:genetics*; D000818:Animals; D003062:Codon; D003596:Cytosine / Q000031:analogs & derivatives; D005658:Fungi / Q000235:genetics; D005796:Genes; D005800:Genes, Fungal; D005872:Giardia / Q000235:genetics; D009154:Mutation; D013045:Species Specificity; D013768:Tetrahymena / Q000235:genetics
chemical_list: D000199:Actins; D003062:Codon; D044503:5-Methylcytosine; D003596:Cytosine