Chemo-immunotherapy and immunological study in carcinoma of larynx and laryngopharynx.
Eighteen of 25 patients had squamous cell carcinoma in the supraglottic region. Anergy to skin test antigen (DNCB) and T-cell mitogen (PHA) was observed in 17 patients with laryngeal and laryngopharyngeal malignancies. Chemo-immunotherapy did not improve the skin reactivity to either agents. However, a rise in absolute T-cell counts was observed following combined therapy. Moreover, T-lymphopenia was detected in the patient group prior to therapy as compared to mean T-cell counts in normal control subjects.
Purohit
J P
JP
Department of ENT, MLB Medical College, Jhansi.
Dayal
D
D
Kapoor
A K
AK
Khan
I U
IU
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007822:Laryngeal Neoplasms / Q000276:immunology / Q000628:therapy*; D016131:Lymphocyte Subsets; D008297:Male; D008875:Middle Aged; D010610:Pharyngeal Neoplasms / Q000276:immunology / Q000628:therapy*; D012882:Skin Tests / Q000379:methods