title: Molecular dissection of the secretory pathway.
abstract: A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution.
authors.affiliation: Program of Cellular Biochemistry and Biophysics, Rockefeller Research Laboratory, Sloan-Kettering Institute, New York, New York 10021.
authors.forename: J E
authors.initials: JE
authors.lastname: Rothman
authors.forename: L
authors.initials: L
authors.lastname: Orci
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002468:Cell Physiological Phenomena; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D007425:Intracellular Membranes / Q000502:physiology; D008561:Membrane Fusion; D008954:Models, Biological; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000502:physiology; D015398:Signal Transduction