title: [Recovery after serious mushroom poisoning (grade IV encephalopathy) with intensive care support and without liver transplantation. Clinical case].
abstract: Despite consistent improvement in its treatment, amatoxin poisoning still extolls an elevated overall mortality, ranging between 10 and 15%, which approaches 100% when severe (grade 3-4 encephalopathy) hepatic failure supervened. Therefore, the proper treatment of intoxication by amatoxin containing mushrooms, and particularly of its complications, remains a challenge in emergency medicine. Klein and coworkers reviewed the role of liver transplantation in amatoxin poisoning as a useful therapeutic tool for patients with severe impairment of liver function. Their indication for intervention is the presence of any of the following signs: grade 2 encephalopathy or higher; prothrombin time twice than normal, despite fresh frozen plasma infusion; hypoglycemia requiring hypertonic glucose infusion; hyperbilirubinemia (greater than 25 mg/dl). During the past autumn two patients with fulminant hepatic failure due to amatoxin poisoning were referred to our institutions as candidates for liver transplantation, since both satisfied Klein's criteria. However, due to shortage of organ donors it was impossible to transplant them over the following days. Despite they did not receive liver transplantation, both patients wakened from coma, their liver function improved, and they recovered from terminal amatoxin poisoning. After one year, both patients are long-term survivors, in good health and without any sequelae either in brain or liver function.
authors.affiliation: Reparto di Rianimazione E. Vecla, IRCCS Ospedale Maggiore di Milano, Università degli Studi di Milano.
authors.forename: G
authors.initials: G
authors.lastname: Ronzoni
authors.forename: S
authors.initials: S
authors.lastname: Vesconi
authors.forename: D
authors.initials: D
authors.lastname: Radrizzani
authors.forename: C
authors.initials: C
authors.lastname: Corbetta
authors.forename: M
authors.initials: M
authors.lastname: Langer
authors.forename: G
authors.initials: G
authors.lastname: Iapichino
mesh_terms: D000293:Adolescent; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006501:Hepatic Encephalopathy / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D009145:Mushroom Poisoning / Q000503:physiopathology / Q000628:therapy*
vernacular_title: Guarigione dopo intossicazione grave da funghi selvatici (encefalopatia di IV grado) con sola terapia medica intensiva e senza trapianto di fegato. Caso clinico.