title: Increased lipid peroxidation in patients on maintenance hemodialysis.
abstract: Lipid peroxidation products, lipid hydroperoxide and malonaldehyde were measured in the serum of patients on maintenance hemodialysis and compared with values obtained from a group of healthy controls. Dialysis patients had significantly elevated levels of lipid peroxidation products (12.9 +/- 1.9 vs. 9.3 +/- 1.3 nmol/ml, mean +/- SD, patients vs. controls, p less than 0.0001). In contrast, the serum transferrin level was significantly lower in the dialysis patients (217 +/- 71 vs. 290 +/- 50 mg/dl, patients vs. controls, p less than 0.0002). Compared to normal controls HDL cholesterol was lower (40 +/- 11 vs. 53 +/- 8, p less than 0.0001) and triglycerides were higher (206 +/- 103 vs. 142 +/- 64, p less than 0.007) in the patient group. The patient group was then divided on the basis of using polysulfone or cupraphane dialyzers. Patients using polysulfone dialyzers had lower levels of 2-thiobarbituric acid-reactive substances (12.3 +/- 0.9 vs. 13.6 +/- 2.1, polysulfone vs. cupraphane, p = 0.05), and higher transferrin concentrations (248 +/- 84 vs. 194 +/- 37, p = 0.03). Thus, in patients on maintenance hemodialysis there was evidence for accelerated lipid peroxidation. This abnormality was more marked in patients using traditional cupraphane dialyzers. The mechanism for this observation remains unclear.
authors.affiliation: Department of Pathology, University of Chicago, Pritzker School of Medicine, Ill.
authors.forename: A
authors.initials: A
authors.lastname: Dasgupta
authors.forename: S
authors.initials: S
authors.lastname: Hussain
authors.forename: S
authors.initials: S
authors.lastname: Ahmad
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000503:physiopathology* / Q000628:therapy; D015227:Lipid Peroxidation / Q000502:physiology*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D006435:Renal Dialysis; D014168:Transferrin / Q000032:analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008054:Lipid Peroxides; D014168:Transferrin; D014280:Triglycerides; D008315:Malondialdehyde