Adhesion of Staphylococcus saprophyticus to renal tubular epithelial cells is mediated by an N-acetyl-galactosamine-specific structure.
S. saprophyticus CCM883 and 9325 were found to adhere to the tubular cell line LLC-PK1. An ELISA technique was used to determine adherence of bacteria and inhibition of adherence by various carbohydrates. Only N-acetyl-galactosamine was found to significantly inhibit adhesion (p less than 0.001), which suggests that the surface component mediating adhesion recognizes structures on the target cell that contain this carbohydrate.
Gatermann
S
S
Institut für Medizinische Mikrobiologie, Medizinische Universität zu Lübeck.
Kretschmar
M
M
Kreft
B
B
Straube
E
E
Schmidt
H
H
Marre
R
R
D000116:Acetylgalactosamine / Q000494:pharmacology*; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells; D004848:Epithelium / Q000382:microbiology; D007684:Kidney Tubules / Q000166:cytology / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects / Q000378:metabolism*
D000116:Acetylgalactosamine