Comparison of prednisolone and RMI-1068 in the ocular irritative response in dogs.
Ocular inflammation was induced in 36 dogs by performing an anterior capsulotomy with a Nd:YAG laser. All dogs were pretreated with topical atropine. Dogs were then divided into three groups: (1) control, with no other pretreatment; (2) pretreatment with the topical dual cyclooxygenase/lipoxygenase inhibitor RMI-1068; and (3) pretreatment with topical prednisolone acetate. Dogs were studied 1-3 hours after lasering. RMI-1068 maintained mydriasis and raised intraocular pressure compared to the control and prednisolone groups. An ocular fluorophotometer used to measure anterior chamber fluorescence after IV injection of sodium fluorescein showed that RMI-1068 decreased anterior chamber fluorescein concentration compared to the control and prednisolone groups. RMI-1068 decreased PGF2 alpha concentrations in the aqueous at 1 and 3 hours compared to the control and prednisolone groups. Prednisolone decreased PGF2 alpha concentrations compared to the control group at 1 h. Concentrations of LTB4 in the aqueous at 1 hour were lower in the RMI-1068 group than in the control and prednisolone groups.
Dziezyc
J
J
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station 77843.
Millichamp
N J
NJ
Rohde
B H
BH
Smith
W B
WB
D000818:Animals; D001082:Aqueous Humor / Q000737:chemistry; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004285:Dogs; D004311:Double-Blind Method; D009877:Endophthalmitis / Q000188:drug therapy*; D005260:Female; D015590:Fluorophotometry; D007429:Intraocular Pressure / Q000187:drug effects; D053685:Laser Therapy; D007908:Lens, Crystalline / Q000601:surgery; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology*; D008297:Male; D011239:Prednisolone / Q000494:pharmacology*; D012025:Reflex, Pupillary / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D011239:Prednisolone