Oral vaccination of skunks with raccoon poxvirus recombinants expressing the rabies glycoprotein or the nucleoprotein.
Twenty nine skunks (Mephitis mephitis) were vaccinated orally with raccoon poxvirus (RCN) recombinants: 10 with a recombinant expressing the rabies virus glycoprotein (RCNRG), 10 with RCNRG mixed with a recombinant expressing the rabies virus nucleoprotein (RCNRN) and nine with RCN alone. Rabies virus neutralizing antibodies were detected in six of the 20 skunks; five skunks (three given RCNRG, two given a mixture of recombinants) survived a rabies challenge that was lethal for nine skunks vaccinated with RCN alone.
Fekadu
M
M
Viral and Rickettsial Zoonoses Branch, Centers for Disease Control, Atlanta, Georgia 30333.
Shaddock
J H
JH
Sumner
J W
JW
Sanderlin
D W
DW
Knight
J C
JC
Esposito
J J
JJ
Baer
G M
GM
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D015967:Gene Expression Regulation, Viral; D006023:Glycoproteins / Q000276:immunology; D012889:Mephitidae; D009698:Nucleoproteins / Q000276:immunology; D011212:Poxviridae / Q000235:genetics / Q000276:immunology; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000276:immunology; D011820:Rabies virus / Q000276:immunology*; D011821:Raccoons; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D006023:Glycoproteins; D009698:Nucleoproteins; D011819:Rabies Vaccines; D014614:Vaccines, Synthetic