title: [An analytic study of cases of childhood diabetes in a pediatric department in Tunis].
abstract: Insulin-dependent diabetes mellitus is common in Tunisia. Eighty-six pediatric cases managed at the diabetes clinic of a department of pediatrics in Tunis from 1979 through 1989 were studied. Relevant clinical and biological findings were abstracted from case-records. Admissions of patients with diabetes mellitus accounted for approximately 0.44% of admissions to the pediatric ward during the study period. Mean age of patients was 7 years. Sex ratio was 0.89. Polyuria with polydipsia and ketoacidosis were the two most common presenting manifestations. Mean blood glucose level at diagnosis was 22.44 mmol/l. Rate of consanguinity was 48%. HLA typing studies demonstrated a high prevalence of DR3 and DR4 alleles and especially of simultaneous expression of both these alleles. Several factors are incriminated in the development of childhood insulin-dependent diabetes mellitus.
authors.affiliation: Service de Pédiatrie, Hôpital d'Enfants, Tunis.
authors.forename: M A
authors.initials: MA
authors.lastname: Mongalgi
authors.forename: M
authors.initials: M
authors.lastname: el Bez
authors.forename: D
authors.initials: D
authors.lastname: Chakroun
authors.forename: H
authors.initials: H
authors.lastname: Jedidi
authors.forename: A
authors.initials: A
authors.lastname: Debbabi
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D003926:Diabetic Coma / Q000453:epidemiology; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006748:Hospital Departments / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D008297:Male; D010372:Pediatrics / Q000706:statistics & numerical data; D011141:Polyuria / Q000453:epidemiology; D011236:Prediabetic State / Q000453:epidemiology; D013894:Thirst; D014416:Tunisia / Q000453:epidemiology
chemical_list: D006684:HLA-DR Antigens
vernacular_title: Etude analytique des cas de diabètes infantiles dans un service de pédiatrie de Tunis.