title: Hypercarbia-induced changes in cerebral blood volume in the cat: a 1H MRI and intravascular contrast agent study.
abstract: Cerebral blood volume changes with arterial carbon dioxide were monitored by proton T1-weighted MR images following administration of the intravascular contrast agent Gd-DTPA labeled with human serum albumin. Without MR contrast, no significant image intensity changes were observed with PaCO2. Following contrast, regional brain image intensities increased significantly over control (0% inspired CO2) in cortical gray, white, and basal ganglia regions with increasing PaCO2 and returned to control intensities upon return to 0% inspired CO2. Imaging of through-plane and in-plane phantoms was performed to assess flow effects. Signal losses of 2 and 6% (relative to no flow) were observed for bulk velocities of 5 mm/s at TE values of 15 ms. An intravascular contrast agent may be useful for MRI monitoring of local cerebral blood volume changes during cerebral perturbations.
authors.affiliation: Department of Radiology, University of California, San Francisco 94143.
authors.forename: M E
authors.initials: ME
authors.lastname: Moseley
authors.forename: W M
authors.initials: WM
authors.lastname: Chew
authors.forename: D L
authors.initials: DL
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Kucharczyk
authors.forename: L
authors.initials: L
authors.lastname: Litt
authors.forename: N
authors.initials: N
authors.lastname: Derugin
authors.forename: J
authors.initials: J
authors.lastname: Dupon
authors.forename: R C
authors.initials: RC
authors.lastname: Brasch
authors.forename: D
authors.initials: D
authors.lastname: Norman
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply; D000818:Animals; D001479:Basal Ganglia / Q000098:blood supply; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology*; D001921:Brain / Q000098:blood supply; D002245:Carbon Dioxide / Q000097:blood / Q000494:pharmacology; D002415:Cats; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media; D005682:Gadolinium; D019786:Gadolinium DTPA; D006859:Hydrogen; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000503:physiopathology*; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008961:Models, Structural; D009942:Organometallic Compounds; D010100:Oxygen / Q000097:blood; D004369:Pentetic Acid
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D002245:Carbon Dioxide; D004369:Pentetic Acid; D006859:Hydrogen; D005682:Gadolinium; D019786:Gadolinium DTPA; D010100:Oxygen