title: A family with multiple instances of definite, probable and possible early-onset Alzheimer's disease.
abstract: A family with a multigenerational history of proven or suspected early-onset Alzheimer's disease (AD) consistent with autosomal-dominant inheritance is described. To date, the pedigree comprises five generations in which there are 13 known affected individuals. The mean age of onset of cognitive deficits in those for whom data are available (n = 11) is 47.6 (s.d. 3.0) years and the mean age of death (n = 10) is 58.8 (s.d. 4.0) years. The variability in the extent and quality of available data illustrates the diagnostic difficulties encountered in ascertaining such an extended pedigree, and the need for caution in interpreting the evidence.
authors.affiliation: Geriatric Psychiatry Services, Queen Elizabeth Hospital, Toronto.
authors.forename: H
authors.initials: H
authors.lastname: Karlinsky
authors.forename: E
authors.initials: E
authors.lastname: Madrick
authors.forename: J
authors.initials: J
authors.lastname: Ridgley
authors.forename: J M
authors.initials: JM
authors.lastname: Berg
authors.forename: R
authors.initials: R
authors.lastname: Becker
authors.forename: C
authors.initials: C
authors.lastname: Bergeron
authors.forename: S
authors.initials: S
authors.lastname: Hodgkinson
authors.forename: M E
authors.initials: ME
authors.lastname: Percy
authors.forename: D
authors.initials: D
authors.lastname: McLachlan
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D025063:Chromosome Disorders; D005260:Female; D005799:Genes, Dominant / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D009864:Ontario; D010375:Pedigree