title: Immunohistochemical study on gastrin-releasing peptide-containing peripheral nerve fibers in rat, macaque and human.
abstract: Distribution of gastrin-releasing peptide (GRP)-containing peripheral nerve fibers in the respiratory organs, digestive tracts and hearts of rat, monkey and human was studied with immunohistochemical method. In the trachea, GRP-immunoreactive nerve fibers were observed in the lamina propria and surrounded ducts and acini of tracheal serous glands with a basket-like appearance. In the lung, immunoreactive nerve fibers were scattered in the lamina propria of bronchi and bronchioles, and also the adventitia of veins. In the digestive organs, such as esophagus, duodenum and jejunum, numerous GRP-immunoreactive nerve fibers were distributed in the lamina propria and muscle layer; especially in the former layer where they were seen running up to the apical part of villi. GRP-containing nerve bundles and branched fibers were also observed in the atrial muscle layer. These results gave a morphological basis to future studies of the functional significance of GRP on autonomic mechanisms.
authors.affiliation: Department of Radiology, Kyoto Prefectural University of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Kawata
authors.forename: M
authors.initials: M
authors.lastname: Takeyama
authors.forename: S
authors.initials: S
authors.lastname: Hitomi
authors.forename: H
authors.initials: H
authors.lastname: Yajima
authors.forename: Y
authors.initials: Y
authors.lastname: Sano
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D004064:Digestive System / Q000294:innervation; D005260:Female; D019886:Gastrin-Releasing Peptide; D005755:Gastrins / Q000378:metabolism; D006329:Heart Conduction System / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008251:Macaca / Q000378:metabolism*; D008297:Male; D009412:Nerve Fibers / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats / Q000378:metabolism*; D012137:Respiratory System / Q000294:innervation
chemical_list: D005755:Gastrins; D010455:Peptides; D019886:Gastrin-Releasing Peptide