title: Post-polio fatigue: a 31P magnetic resonance spectroscopy investigation.
abstract: Changes in high energy phosphates (HEP) and intramuscular pH during exercise were measured in 17 patients with post-polio fatigue and in 28 healthy controls using 31P magnetic resonance spectroscopy (MRS). Subjects performed a dynamic hand grip exercise at low and high intensity. Mean changes in the HEP and pH showed no significant differences between the groups, although the post-polio group's response was highly variable. Six patients showed evidence of a lower lactate accumulation during the high intensity exercise when compared with controls. These data suggest that the whole body fatigue experienced by polio survivors is not related to any systemic metabolic abnormality.
authors.affiliation: Department of Nuclear Medicine, St. Joseph's Health Center, London, Ontario, Canada.
authors.forename: R T
authors.initials: RT
authors.lastname: Thompson
authors.forename: P M
authors.initials: PM
authors.lastname: Barton
authors.forename: G D
authors.initials: GD
authors.lastname: Marsh
authors.forename: M G
authors.initials: MG
authors.lastname: Cameron
authors.forename: D G
authors.initials: DG
authors.lastname: Gravelle
authors.forename: J T
authors.initials: JT
authors.lastname: Hsieh
authors.forename: K C
authors.initials: KC
authors.lastname: Hayes
authors.forename: A A
authors.initials: AA
authors.lastname: Driedger
mesh_terms: D000328:Adult; D004576:Electromyography; D015444:Exercise; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000378:metabolism; D010759:Phosphorus Isotopes; D016262:Postpoliomyelitis Syndrome / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology
chemical_list: D010710:Phosphates; D010759:Phosphorus Isotopes