title: Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx.
abstract: A computer analysis of the amino acid sequences of rat and human 58-kD sterol carrier protein and Escherichia coli acetyl-CoA acyltransferase reveals that the two proteins have a segment of about 350 residues with strong sequence similarity. The ALIGN comparison scores for the rat and human sterol carrier proteins and the E. coli enzyme are 8.25 and 8.8 SD, respectively. The catalytically active cysteine of E. coli acetyl-CoA acyltransferase (cysteine 91) aligns with cysteine 93 and cysteine 94 on human and rat 58-kD sterol carrier protein, respectively.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla 92093-0623.
authors.forename: M E
authors.initials: ME
authors.lastname: Baker
authors.forename: J T
authors.initials: JT
authors.lastname: Billheimer
authors.forename: J F
authors.initials: JF
authors.lastname: Strauss
mesh_terms: D000101:Acetyl-CoA C-Acetyltransferase; D000102:Acetyl-CoA C-Acyltransferase / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats; D012689:Sequence Homology, Nucleic Acid
chemical_list: D002352:Carrier Proteins; C072087:sterol carrier proteins; D000102:Acetyl-CoA C-Acyltransferase; D000101:Acetyl-CoA C-Acetyltransferase