A new technique to study the mechanical properties of collagen lattices.
A new technique to study the mechanical properties of collagen lattices or dermal equivalents is described. With the help of the load-extension curve obtained with a uniaxial traction apparatus, a stiffness modulus varying from 0.06 to 1 MPa is calculated from the studied parameters (duration of culture, collagen and fibroblast concentration). The technique is presented as a new tool for testing the effect of pharmacological agents on the mechanical properties of the skin.
Chapuis
J F
JF
Laboratory of Cutaneous Biology, Chu St Jacques, Besançon, France.
Agache
P
P
D001696:Biomechanical Phenomena; D002452:Cell Count; D002478:Cells, Cultured; D003094:Collagen / Q000737:chemistry*; D003461:Crystallography; D004548:Elasticity; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D016014:Linear Models; D013314:Stress, Mechanical; D013718:Tensile Strength
D003094:Collagen