Platelet antibody binding and spontaneous aggregation in 21 lupus anticoagulant patients.
In order to ascertain the role of the antiphospholipid antibody in the pathogenesis of thrombotic disorders, a study of 21 lupus anticoagulant-positive patients was done by a number of serologic and functional platelet tests. In immunofluorescent studies, we found that 80% showed a mitochondrial pattern on HEp cells and all patients gave an ubiquitously intense staining of donor platelets. By a microscopic spontaneous aggregation test, all lupus anticoagulant-positive patients showed accelerated platelet aggregation which was calcium-independent. The results show that the plasma of lupus anticoagulant-positive patients contains a platelet-binding antibody and causes spontaneous agglutination of platelets. These properties may play a role in the thrombogenesis common to the antiphospholipid syndrome.
Wiener
H M
HM
Department of Medicine A, Tel Aviv Medical Center, Israel.
Vardinon
N
N
Yust
I
I
D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology* / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology* / Q000378:metabolism; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation; D013923:Thromboembolism / Q000209:etiology
D016682:Lupus Coagulation Inhibitor; D002118:Calcium