title: [Mutagenesis, induced by phosphotriester analogs of oligonucleotides and directed to the cleavage site of double-spiral DNA].
abstract: The mutagenic properties of phosphotriester analogues revealed in course of interaction with linearized plasmid DNA were studied. The plasmid-based model system permitting one to test reliably the induced mutations is proposed. The efficiency of mutagenesis was shown to depend on the length of the oligonucleotide-mutagen and the genotype of the transformed Escherichia coli strain. The possible mechanisms involved in mutagenesis are discussed.
authors.forename: V A
authors.initials: VA
authors.lastname: Petrenko
authors.forename: L I
authors.initials: LI
authors.lastname: Karpenko
authors.forename: S I
authors.initials: SI
authors.lastname: Tat'kov
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Smirnova
authors.forename: G A
authors.initials: GA
authors.lastname: Kuz'micheva
authors.forename: A A
authors.initials: AA
authors.lastname: Il'ichev
mesh_terms: D001435:Bacteriophages / Q000235:genetics; D001483:Base Sequence; D004269:DNA, Bacterial / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics; D004952:Esters / Q000737:chemistry*; D005798:Genes, Bacterial; D005814:Genes, Viral; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D009841:Oligonucleotides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
chemical_list: D004269:DNA, Bacterial; D004279:DNA, Viral; D004952:Esters; D009841:Oligonucleotides; D009943:Organophosphorus Compounds
vernacular_title: Mutagenez, indutsirovannyĭ fosfotriéfirnymi analogami oligonukleotidov i napravlennyĭ na mesta razryva dvuspiral'noĭ DNK.