title: Configurational and volumetric changes of the early prenatal human cerebellar dentate nucleus.
abstract: The three-dimensional configurational and volumetric changes of the human dentate nucleus (DN) during intrauterine life were examined in 11 fetuses (11 to 27-28 weeks of gestation). During intrauterine life, the dentate nuclear profile successively passes through the pongid, cercopithecus and prosimian phases of configuration. The smooth, elongated, crescent-shaped DN of 11 weeks lies along a dorsal-ventral axis. A 45 degrees clockwise shift in the position of the nucleus changes the axis to dorsomedial-ventrolateral at 14-15 weeks, which is maintained in subsequent ages. The formation of gyri is preceded by a thinning of the substantia grisea. This begins at 17-18 weeks in the dorso-medial region of the DN. Gyri first make their appearance at 24-25 weeks. The DN of 27-28 weeks resembles the adult human DN. Two regions are discernible at this stage--a microgyric, magnocellular region and a macrogyric, parvocellular region. The DN volume increases with increasing gestational age. Between 14-15, 19-20 and 24-25 weeks the volumetric increase is statistically significant. This is simultaneously accompanied by a modification of the configuration of the DN.
authors.affiliation: Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
authors.forename: A
authors.initials: A
authors.lastname: Hayaran
authors.forename: S
authors.initials: S
authors.lastname: Wadhwa
authors.forename: V
authors.initials: V
authors.lastname: Bijlani
mesh_terms: D002454:Cell Differentiation; D002529:Cerebellar Nuclei / Q000196:embryology*; D005865:Gestational Age; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009024:Morphogenesis