title: 2,4-D toxicosis.III: An attempt to produce 2,4-D toxicosis in dogs on treated grass plots.
abstract: Eighteen English pointer dogs were randomly assigned to 3 outdoor grass-plot enclosures (6/enclosure) uniformly sprayed once with either the 2,4-dichlorophenoxyacetic acid (2,4-D) dimethylamine formulation (DMA-4) at the maximum recommended application rate, DMA-4 at 4 times the maximum recommended application rate, or the DMA-4 vehicle alone at 4 times the maximum recommended application rate. A heavy rain shower occurred 24 h after application. The dogs were observed for clinical signs and evaluated using an electroencephalograph, electrocardiograph (lead I), and electromyograph prior to exposure, and either 1 or 7 d after continuous exposure. Clinical examination, hematologic and serum biochemical data were obtained, and serum, urine and kidney 2,4-D were quantified. Half of the dogs from each group were killed after 1 d of continuous exposure, while the other half were killed after 7 d. Gross postmortem and histologic examinations were conducted on each dog. No obvious 2,4-D effects were detected in any of the dogs.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
authors.forename: E K
authors.initials: EK
authors.lastname: Arnold
authors.forename: R A
authors.initials: RA
authors.lastname: Lovell
authors.forename: V R
authors.initials: VR
authors.lastname: Beasley
authors.forename: A J
authors.initials: AJ
authors.lastname: Parker
authors.forename: J R
authors.initials: JR
authors.lastname: Stedelin
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000378:metabolism / Q000506:poisoning*; D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D004576:Electromyography; D004781:Environmental Exposure; D005260:Female; D007668:Kidney / Q000378:metabolism; D008297:Male; D011041:Poisoning / Q000209:etiology / Q000473:pathology / Q000503:physiopathology
chemical_list: D015084:2,4-Dichlorophenoxyacetic Acid