title: Induction of covalent DNA adducts in rodents by tamoxifen.
abstract: The antiestrogen tamoxifen, increasingly used as adjuvant treatment for breast cancer, has been found to covalently modify DNA of rodents. For instance, the liver DNA of female Sprague-Dawley rats treated with a single injection of tamoxifen contained two DNA adducts. Four additional DNA adducts were formed and adduct concentrations increased 5- 7- and 10-15-fold after three and six tamoxifen injections, respectively, from levels observed after a single dose. The accumulation of DNA adducts with repeated administrations of tamoxifen to rodents may make this drug a poor choice for the chronic preventative treatment of breast cancer.
authors.affiliation: Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550-2782.
authors.forename: X L
authors.initials: XL
authors.lastname: Han
authors.forename: J G
authors.initials: JG
authors.lastname: Liehr
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D006224:Cricetinae; D004247:DNA / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D013629:Tamoxifen / Q000378:metabolism* / Q000633:toxicity
chemical_list: D013629:Tamoxifen; D004247:DNA; D001205:Ascorbic Acid; D000111:Acetylcysteine