title: Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization.
abstract: In situ suppression hybridization with recombinant bacteriophage DNA libraries for chromosomes 8 and 21 was performed in two cases of acute nonlymphocytic leukemia, type FAB M2. In both cases, cytogenetic analysis by conventional G-banding revealed t(8;21)(q22;q22). In situ suppression hybridization was able to prove the reciprocal nature of the translocation in both cases by identifying the terminal end of chromosome 21 translocated to the derivative chromosome 8q-.
authors.affiliation: Innere Universitätsklinik (Tumorforschung), West German Cancer Center Essen.
authors.forename: S
authors.initials: S
authors.lastname: Popp
authors.forename: A
authors.initials: A
authors.lastname: Jauch
authors.forename: J Y
authors.initials: JY
authors.lastname: Qiu
authors.forename: B
authors.initials: B
authors.lastname: Smialek
authors.forename: T
authors.initials: T
authors.lastname: Cremer
authors.forename: R
authors.initials: R
authors.lastname: Becher
mesh_terms: D002869:Chromosome Aberrations / Q000175:diagnosis*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002891:Chromosomes, Human, Pair 21 / Q000648:ultrastructure*; D002898:Chromosomes, Human, Pair 8 / Q000648:ultrastructure*; D015342:DNA Probes; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000473:pathology*; D009693:Nucleic Acid Hybridization; D014178:Translocation, Genetic
chemical_list: D015342:DNA Probes