[A comparative study of properties of paracetamol tablets of the matrix type].
Our study was to compare the quantitative and qualitative effects of 2 polymeric agents (méthylcellulose, hydroxypropylmethylcellulose) and of 2 diluants (lactose and dicalcic phosphate) on the compression properties and sustained liberation of acetaminophen matrixes. Three experimental plans were permitted the experimentation; regression equations were used for our analysis of the results. The results we obtained show the superiority importance of the effect of the diluant/acetaminophen ratio over the liberation of the drug, as well as the better efficiency of méthylcellulosic matrixes. Thence to its solubility, the lactose helps to a faster liberation.
Benkaddour
N
N
Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Université Paul Sabatiner, Toulouse.
Michaud
P
P
Rodriguez
F
F
Rouffiac
R
R
D000082:Acetaminophen / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D005079:Excipients; D013607:Tablets
D005079:Excipients; D013607:Tablets; D000082:Acetaminophen
Etude comparée des propriétés de comprimés de paracétamol de type matriciel.