[Synchronization of plasmapheresis and pulse therapy in the complex treatment of children with highly active glomerulonephritis].
To suppress the activity of glomerulonephritis, lupus and primary chronic mixed one, 13 children received plasmapheresis synchronously with pulse therapy with cyclophosphamide or prednisolone. Plasmapheresis was carried out daily for 3 days. Six hours after the last session and on days 4 and 5 of the treatment pulse therapy was provided, followed by conventional intake of prednisolone per os in combination with azathioprine or cyclophosphamide. Beneficial therapeutic results were obtained in 10 patients within 3 to 6 weeks. The effect turned out insufficient in a patient with associated systemic lupus erythematosus, and rapid-progressing nephritis and in a child with primary chronic glomerulonephritis of the mesangiocapillary type with fibroplastic transformation and persistent nephrotic syndrome. No therapeutic effect was attained in a patient with focal segmental glomerulosclerosis running its course with long persistent nephrotic syndrome.
Kartasheva
V I
VI
Donov
G I
GI
Fomenko
T M
TM
Klimov
Iu V
IuV
Osminina
M K
MK
D000293:Adolescent; D001379:Azathioprine / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005921:Glomerulonephritis / Q000628:therapy*; D015432:Glomerulonephritis, Membranoproliferative / Q000628:therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000628:therapy; D006801:Humans; D008181:Lupus Nephritis / Q000628:therapy; D009402:Nephrosis, Lipoid / Q000628:therapy; D010956:Plasmapheresis; D011239:Prednisolone / Q000008:administration & dosage*; D013997:Time Factors
D003520:Cyclophosphamide; D011239:Prednisolone; D001379:Azathioprine
Sinkhronizatsiia plazmafereza i lul's-terapii v kompleksnom lechenii vysokoaktivnogo glomerulonefrita u deteĭ.