A low-copy repeat located in subtelomeric regions of 14 different human chromosomal termini.
Two cosmid clones, cG1A3 and cG1A6, containing large blocks of a telomeric repeat sequence, (TTAGGG)n, were isolated independently. Restriction mapping and fingerprinting studies suggested that cosmid cG1A6 is entirely contained within cG1A3. Competitive in situ hybridization localized cG1A3 to 14 different human telomeres and one internal site at 2q14----q21, indicating the presence of a subtelomeric low-copy repeat within this cosmid.
Weber
B
B
Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
Allen
L
L
Magenis
R E
RE
Hayden
M R
MR
D001483:Base Sequence; D015139:Blotting, Southern; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D003360:Cosmids / Q000235:genetics; D016172:DNA Fingerprinting; D005453:Fluorescence; D006801:Humans; D008969:Molecular Sequence Data; D009693:Nucleic Acid Hybridization; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D015183:Restriction Mapping; D016615:Telomere