Vagally-induced non-adrenergic, non-cholinergic inhibitory motility in the rabbit stomach "in vivo".
In atropine-treated rabbits, electrical stimulation of vagal nerves at low frequency and low basal gastric volumes evoked a biphasic response: rapid onset relaxation followed by rebound contractions. Increase in the frequency of stimulation and/or in basal gastric volume caused a depression of the rebound contraction and a conversion of the biphasic response into a triphasic one: i.e., the post-stimulus excitatory motility was followed by a long-lasting slow relaxation. The rebound contraction, which was mimicked by arterial injections of prostaglandin E2, appears to be a key factor in the conversion of one type of response into the other.
Baccari
M C
MC
Department of Physiology, University of Florence, Italy.
Calamai
F
F
Staderini
G
G
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D002799:Cholinergic Fibers / Q000502:physiology*; D015232:Dinoprostone / Q000502:physiology; D004558:Electric Stimulation; D005746:Gastric Emptying / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D011817:Rabbits; D013270:Stomach / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*
D015232:Dinoprostone