title: A comparative study of the biological properties of venoms of some old world vipers (subfamily viperinae).
abstract: 1. The hemorrhagic, procoagulant, anticoagulant, phosphodiesterase, hyaluronidase, alkaline phosphomonoesterase, 5'-nucleotidase, arginine ester hydrolase, phospholipase A, L-amino acid oxidase and protease activities of 30 samples of venoms from nine species (12 taxa) of the old world vipers (Subfamily Viperinae) including snakes from the genera Bitis, Causus, Cerastes, Echis, Eristicophis and Pseudocerastes, were determined and the Sephadex G-75 gel filtration patterns for some of the venoms were also examined. 2. Examination of the biological properties of the venoms of the Viperinae tested indicates the presence of common venom biological characteristics at the various phylogenic levels. 3. Venoms of most species of the Viperinae examined exhibited characteristic biological properties at the species level, and this allows the differentiation of the Viperinae species by differences in their biological properties. 4. Particularly useful for this purpose, are the effects of venom on kaolin-cephalin clotting time of platelet poor rabbit plasma and the Sephadex G-75 gel filtration pattern and arginine ester hydrolase activity of the venom.
authors.affiliation: Department of Biochemistry, University of Malaya, Kuala Lumpur.
authors.forename: N H
authors.initials: NH
authors.lastname: Tan
authors.forename: G
authors.initials: G
authors.lastname: Ponnudurai
mesh_terms: D000818:Animals; D000925:Anticoagulants; D002850:Chromatography, Gel; D003029:Coagulants; D006470:Hemorrhage / Q000139:chemically induced; D051379:Mice; D012911:Snakes / Q000145:classification; D013045:Species Specificity; D014757:Viper Venoms / Q000737:chemistry / Q000201:enzymology / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D003029:Coagulants; D014757:Viper Venoms