title: Gingival hyperplasia induced by nifedipine.
abstract: We describe 4 cases of gingival hyperplasia induced by nifedipine, together with clinical and histological findings. Hyperplasia of the interdental papillae was observed in all cases. Histologic examination showed multilayered epithelial parakeratosis with variations in the width, proliferation, reticulation and elongation of the rete pegs. Substitution of another drug and improvement of oral hygiene led to reduction of the gingival overgrowth without gingivectomy. These treatments are essential for gingival hyperplasia induced by nifedipine.
authors.affiliation: Second Department of Oral Surgery, Nihon University school of Dentistry, Matsudo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Omata
authors.forename: J
authors.initials: J
authors.lastname: Shibutani
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Kawana
authors.forename: H
authors.initials: H
authors.lastname: Teshigawara
authors.forename: S
authors.initials: S
authors.lastname: Nakao
authors.forename: A
authors.initials: A
authors.lastname: Fujii
mesh_terms: D000368:Aged; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects*
chemical_list: D009543:Nifedipine