title: Subtrigonal phenol injection. How safe and effective is it?
abstract: A series of 24 patients underwent 27 transtrigonal phenol injections for the treatment of bladder instability. Only 2 of 18 patients with detrusor instability and 2 of 6 with detrusor hyperreflexia continued to derive benefit from the procedure 6 months after it was carried out. Serious complications attributable to phenol were seen in 2 patients in this series and in a further 4 patients referred for complications resulting from this therapy in other centres. These results and a review of the literature lead us to suggest that transvesical phenol injection should not be used except in the hyper-reflexic bladder when no alternative treatment is possible. Particular care should be exercised in patients who have undergone extensive prior surgery or radiotherapy.
authors.affiliation: Department of Urology, Middlesex Hospital, London.
authors.forename: C R
authors.initials: CR
authors.lastname: Chapple
authors.forename: S J
authors.initials: SJ
authors.lastname: Hampson
authors.forename: R T
authors.initials: RT
authors.lastname: Turner-Warwick
authors.forename: P H
authors.initials: PH
authors.lastname: Worth
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005355:Fibrosis; D005402:Fistula / Q000209:etiology; D006801:Humans; D007267:Injections / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000188:drug therapy*; D019800:Phenol; D010636:Phenols / Q000008:administration & dosage*; D014515:Ureteral Diseases / Q000209:etiology; D014549:Urinary Incontinence / Q000188:drug therapy*; D016055:Urinary Retention / Q000209:etiology; D014719:Vesicovaginal Fistula / Q000209:etiology
chemical_list: D010636:Phenols; D019800:Phenol