title: [Histopathological parameters and lymphatic metastasis in supraglottic laryngeal carcinoma].
abstract: Histopathologic parameters in predicting lymph node metastasis of supraglottic laryngeal carcinoma. A systematic clinical-pathological study was performed on fifty-three resected cases of supraglottic laryngeal squamous cell carcinoma, followed up for at least 5 years. The aim of the research was to evaluate histopathologic parameters in predicting lymph node metastasis (N+) as expression of biological malignancy of the neoplasm. The following neoplastic microscopical features were studied: histopathologic and cytologic grading, pattern of growth, peritumoral inflammatory infiltrate, stromal reaction, tumoral necrosis. The results are as follows: stromal reaction and cytologic grading are not useful to identify N+ and N- cases. Cases with high and low degree of differentiation (Broder's grading) are significantly correlated respectively to low (14.3%) and high (70%) incidence of lymph node metastasis (p less than 0.03). A clear correlation is present between the pattern of growth "pushing" and lacking of node metastasis (84.6%). A favorable prognosis significance seems to be linked with the presence of peritumoral lymphoplasmocytic infiltrate, which results to be a marker of cases in which lymph node metastasis incidence is very low (5.5%; p less than 0.001). On the contrary lymph node metastasis incidence increase when tumoral necrosis is present (76.5%; p less than 0.001).
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università di Firenze.
authors.forename: A
authors.initials: A
authors.lastname: Giannini
authors.forename: M B
authors.initials: MB
authors.lastname: Ninu
authors.forename: E
authors.initials: E
authors.lastname: Gallina
authors.forename: O
authors.initials: O
authors.lastname: Fini-Storchi
authors.forename: C
authors.initials: C
authors.lastname: Urso
authors.forename: R
authors.initials: R
authors.lastname: Bondi
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D005355:Fibrosis; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007249:Inflammation; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis / Q000473:pathology*; D009336:Necrosis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis
vernacular_title: Parametri istopatologici e metastatizzazione linfonodale nel carcinoma laringeo sopraglottico.