Vaginal absorption of low-dose tranexamic acid from impregnated tampons.
Tranexamic acid (TA), an antifibrinolytic drug, is usually administered orally to women with menorrhagia. This route of administration is associated with adverse side-effects, therefore tampons impregnated with TA were used to assess the absorption of the drug across the vaginal epithelium. Blood levels of TA in group A (9 patients), who had one tampon inserted, and group B (10 patients), who had a tampon inserted at 2-hourly intervals so that a total of 3 tampons were administered over a 6-hour period, demonstrated absorption of the drug into the blood stream in low concentrations.
Moodley
J
J
Department of Obstetrics and Gynaecology, University of Natal.
Cohen
M
M
Devraj
K
K
Dutton
M
M
D000042:Absorption; D000328:Adult; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy*; D013630:Tampons, Surgical; D014148:Tranexamic Acid / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D014621:Vagina / Q000378:metabolism*
D014148:Tranexamic Acid