title: Adhesion of Staphylococcus saprophyticus to renal tubular epithelial cells is mediated by an N-acetyl-galactosamine-specific structure.
abstract: S. saprophyticus CCM883 and 9325 were found to adhere to the tubular cell line LLC-PK1. An ELISA technique was used to determine adherence of bacteria and inhibition of adherence by various carbohydrates. Only N-acetyl-galactosamine was found to significantly inhibit adhesion (p less than 0.001), which suggests that the surface component mediating adhesion recognizes structures on the target cell that contain this carbohydrate.
authors.affiliation: Institut für Medizinische Mikrobiologie, Medizinische Universität zu Lübeck.
authors.forename: S
authors.initials: S
authors.lastname: Gatermann
authors.forename: M
authors.initials: M
authors.lastname: Kretschmar
authors.forename: B
authors.initials: B
authors.lastname: Kreft
authors.forename: E
authors.initials: E
authors.lastname: Straube
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: R
authors.initials: R
authors.lastname: Marre
mesh_terms: D000116:Acetylgalactosamine / Q000494:pharmacology*; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D002460:Cell Line; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells; D004848:Epithelium / Q000382:microbiology; D007684:Kidney Tubules / Q000166:cytology / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000116:Acetylgalactosamine