title: Intravesical chemotherapy (mitomycin C) versus immunotherapy (bacillus Calmette-Guérin) in superficial bladder cancer.
abstract: Both intravesical mitomycin C (MMC) and bacillus Calmette-Guérin (BCG; Pasteur strain F) were effective in the present prospective randomized multicenter study consisting of 91 patients with frequently recurrent superficial (Ta-T1) bladder cancer. The result was in favour of BCG, as shown by the measurements with complete response (CR), disease-free interval and recurrence rate. CR of 58% with MMC and 40% with BCG were reached in 22 instillation series on carcinoma in situ of 18 patients. Due to side effects, MMC instillations were discontinued in 8.6%, and BCG instillations in 19.6%, respectively. After the 2-year follow-up also 1 case of pulmonary tuberculosis occurred in the BCG group.
authors.affiliation: Urological Clinic, Helsinki University Central Hospital, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Rintala
authors.forename: K
authors.initials: K
authors.lastname: Jauhiainen
authors.forename: O
authors.initials: O
authors.lastname: Alfthan
authors.forename: E
authors.initials: E
authors.lastname: Hansson
authors.forename: H
authors.initials: H
authors.lastname: Juusela
authors.forename: K
authors.initials: K
authors.lastname: Kanerva
authors.forename: H
authors.initials: H
authors.lastname: Korhonen
authors.forename: J
authors.initials: J
authors.lastname: Permi
authors.forename: M
authors.initials: M
authors.lastname: Sotarauta
authors.forename: T
authors.initials: T
authors.lastname: Vaalasti
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects / Q000627:therapeutic use*; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D001500:BCG Vaccine; D016685:Mitomycin