[Regulation of by arginine of cytochrome p-450 activity and lipid peroxidation in rat liver and testicular tissue during hypoxia].
Arginine, preadministered intraperitoneally at a dose of 120 mg per 100 g of body mass before hypoxia, decreased content of diene conjugates by 42-64% and Schiff bases by 7-15% in rat liver and testicular microsomal membranes as compared with control rats nontreated with arginine. Under these conditions cytochrome P-450 catalytic activity with aniline as a substrate was increased by 65-152% and with amidopyrine as a substrate--by 72-148%, respectively. Exogenous arginine inhibited an increase in membranes microviscosity, specific for hypoxic state; relative microviscosity of lipid bilayer was decreased by 36% and of the protein-lipid contact zones--by 84% as compared with control hypoxic animals.
Shugaleĭ
V S
VS
Ananian
A A
AA
Miliutina
N P
NP
Chin Kim
T T
TT
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D002384:Catalysis; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005453:Fluorescence; D000860:Hypoxia / Q000201:enzymology*; D008051:Lipid Bilayers; D015227:Lipid Peroxidation; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D013379:Substrate Specificity; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D008051:Lipid Bilayers; D003577:Cytochrome P-450 Enzyme System; D001120:Arginine
Reguliatsiia argininom aktivnosti tsitokhroma P-450 i perekisnogo okisleniia lipidov v pecheni i semennikakh krys pri gipoksii.