title: Carcinoma arising in an odontogenic keratocyst with orbital invasion.
abstract: A 54-year-old black female presented with proptosis and reduced visual acuity of the left eye. Computerized tomography (CT) revealed tumor involvement of the left cavernous sinus and posterior orbit. The patient had a nineteen year history of a left-sided jaw tumor which recurred despite surgical and radiation therapy. Biopsy demonstrated a parakeratinized odontogenic keratocyst with areas of transformation into an invasive squamous cell carcinoma. Although a parakeratinized odontogenic keratocyst may be locally invasive, to our knowledge, no case of a parakeratinized odontogenic keratocyst involving the orbit or cavernous sinus previously has been reported.
authors.affiliation: Department of Ophthalmology, Medical University of South Carolina, Charleston 29425.
authors.forename: H L
authors.initials: HL
authors.lastname: Hennis
authors.forename: W C
authors.initials: WC
authors.lastname: Stewart
authors.forename: B
authors.initials: B
authors.lastname: Neville
authors.forename: K F
authors.initials: KF
authors.lastname: O'Connor
authors.forename: D J
authors.initials: DJ
authors.lastname: Apple
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002426:Cavernous Sinus / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009364:Neoplasm Recurrence, Local; D009808:Odontogenic Tumors / Q000473:pathology*; D009918:Orbital Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed