Prophylaxis and treatment of newborn endotoxic shock with anti-lipid A monoclonal antibodies.
The newborn is very susceptible to gram-negative sepsis/septic shock. The mortality of newborn endotoxic shock continues to be high. Since lipid A is responsible for the toxic effects of lipopolysaccharide, anti-lipid A antibodies may prevent endotoxic shock in the newborn. This study showed that both anti-lipid A monoclonal IgG (A78S1) and anti-lipid A monoclonal IgM (A523) decreased the mortality of endotoxic shock in 10 day old rats. Prophylactic administration of A78S1 and A523 to the pregnant rat decreased the mortality of endotoxic shock in their 0-day-old offspring. Prophylaxis was due to transplacental passage of A78S1 treatment. The mechanism of prophylaxis remains unclear in A523 treatment.
Goto
M
M
Department of Pediatrics, Loyola University of Chicago, Stritch School of Medicine, Maywood, Illinois 60153.
Zeller
W P
WP
Hurley
R M
RM
Jong
J S
JS
Lee
C H
CH
D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000627:therapeutic use; D007075:Immunoglobulin M / Q000627:therapeutic use; D008050:Lipid A / Q000276:immunology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000517:prevention & control / Q000628:therapy*
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008050:Lipid A