Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: I. Experimental design and exposure system.
The rationale for selection of an animal model, the experimental design, and the design and evaluation of an exposure system used in studies of 60-Hz magnetic fields are described. The studies were conceived to assay development of cancer and immune responsiveness in mice exposed to magnetic fields. The exposure system utilized a quadrupole-coil configuration to minimize stray magnetic fields. Four square-wound coil provided a uniform field within a volume occupied by 16 animal cages. The magnetic field had a mean flux density of 2 mT that varied less than +/- 10% within the volume occupied by animals' cages. The flux density decreased to less than 0.1 microT at a distance of 2 m from the coils. In each exposure system 32 animals could be housed in plastic cages.
Stuchly
M A
MA
Bureau of Radiation and Medical Devices, Health & Welfare Canada, Ottawa, Ontario.
Lecuyer
D W
DW
McLean
J
J
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004781:Environmental Exposure; D051379:Mice; D012107:Research Design; D012878:Skin Neoplasms / Q000139:chemically induced / Q000209:etiology*; D013755:Tetradecanoylphorbol Acetate
D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate