title: Effect of cimetidine administration on the pharmacokinetics of pirmenol.
abstract: The potential for a drug-drug interaction between pirmenol, an extensively metabolized antiarrhythmic agent, and cimetidine, an inhibitor of hepatic drug-metabolizing enzymes, was evaluated in eight healthy adults. A single 150-mg oral dose of pirmenol was administered on study days 1 and 8 and oral cimetidine, 300-mg QID, was administered on study days 4 through 11. Plasma and urine samples were collected after each pirmenol dose for determination of pirmenol concentration. Mean pirmenol concentration-time curves and pharmacokinetic parameters, including elimination rate constant, were not significantly altered by concomitant administration of cimetidine.
authors.affiliation: Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, Buffalo, New York.
authors.forename: K A
authors.initials: KA
authors.lastname: Stringer
authors.forename: M E
authors.initials: ME
authors.lastname: Lebsack
authors.forename: A B
authors.initials: AB
authors.lastname: Cetnarowski-Cropp
authors.forename: A L
authors.initials: AL
authors.lastname: Goldfarb
authors.forename: L L
authors.initials: LL
authors.lastname: Radulovic
authors.forename: H N
authors.initials: HN
authors.lastname: Bockbrader
authors.forename: T
authors.initials: T
authors.lastname: Chang
authors.forename: A J
authors.initials: AJ
authors.lastname: Sedman
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D010880:Piperidines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D010880:Piperidines; D002927:Cimetidine; C024318:pirmenol