[The significance of a congenital enterovirus infection in the pathogenesis of transient intrainfectious nephropathy and interstitial nephritis detected in children with influenza-like and acute respiratory diseases].
The paper presents the data confirming the hypothesis on the involvement of the congenital enteroviral infection in etiology of chronic nephropathy manifesting in children in the presence of influenza-like and acute respiratory infections diseases. 100 relevant children were examined. Family history indicated a high risk of enteroviruses inheritance from mothers who were chronic carriers in 19 out of 20 children with pyelonephritis or interstitial nephritis (95%), in 17 out of 23 children with transitory nephropathy (73.9%) and 16 out of 57 patients without nephropathy (28.1%). Coxsackie enteroviruses (A and B) occurred in the urinary sediment in 82.3, 68.4, 29.5% of the patients from the groups under comparison, respectively. In children free of nephropathy the viruses manifested primarily in the seasons with the highest prevalence of the enteroviral diseases, in those with nephropathy Coxsackie viruses detection rate was not season-related. Recognition of enteroviruses (Coxsackie B, as a rule) was significantly related to the risk of the transmission from the mother. Persistence of the viruses in the cells of the urinary system of children with congenital viral infection seems to run subclinically for a long time. Influenza and other acute respiratory diseases promoted activation of the endogenic infection which resulted in transitory nephropathy or interstitial nephritides.
Lozovskaia
L S
LS
Kablukova
E K
EK
D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003384:Coxsackievirus Infections / Q000150:complications / Q000151:congenital* / Q000453:epidemiology / Q000382:microbiology; D004770:Enterovirus / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D009395:Nephritis, Interstitial / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D011704:Pyelonephritis / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D012307:Risk Factors
Znachenie vrozhdennoĭ énterovirusnoĭ infektsii v patogeneze tranzitornoĭ intrainfektsionnoĭ nefropatii i interstial'nykh nefritov, vyiavliaemykh u deteĭ pri grippopodobnykh i ostrykh respiratornykh zabolevaniiakh.