title: [Fixed drug combination of ACE inhibitor plus diuretic. Results of an open multicenter study for the treatment of hypertension].
abstract: An open multicenter trial involving 7,232 participating physicians, was performed to assess the anti-hypertensive efficacy and tolerance of a fixed combination of captopril and hydrochlorothiazide (Capozide) given once daily to 34,976 patients (mean age 58.5 +/- 11.4 years) with mild-to-moderate hypertension inadequately controlled by previous anti-hypertensive treatment. After 8 weeks, the response rate to a daily dose of Capozide 25 or 50 was 87.2%. Within this period, the mean systolic/diastolic blood pressure dropped from 175 +/- 16/103 +/- 5 mmHg to 150 +/- 13/88 +/- 7 mmHg (p less than 0.001). In 81% of the questionnaires, treatment with the combination was rated superior to the previous treatment; in only 5% was it considered inadequate. Side effects, for the most part mild, were reported by 7.4% of the patients. Treatment with Capozide was discontinued, or another form of treatment substituted in 12.9% of the cases.
authors.affiliation: Medizinische Klinik I, Städtische Kliniken Dortmund, Akademisches Lehrkrankenhaus.
authors.forename: R M
authors.initials: RM
authors.lastname: Lederle
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D004338:Drug Combinations; C044959:captopril, hydrochlorothiazide drug combination; D006852:Hydrochlorothiazide; D002216:Captopril
vernacular_title: Fixe Arzneimittelkombination von ACE-Hemmer plus Diuretikum. Ergebnisse einer offenen Multicenterstudie zur Hypertoniebehandlung.