Intrathecal synthesis of soluble class I antigens in multiple sclerosis.
We have studied the intrathecal synthesis of soluble class I antigens (sHLA), reflected by the index IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin), in multiple sclerosis (MS). IH was increased in patients in relapse, but normal in patients in remission; these findings show that there is a high lymphocyte activation within the central nervous system in patients with clinically active MS.
Alvarez-Cermeño
J C
JC
Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain.
Villar
L M
LM
Nocito
M
M
Bootello
A
A
González-Porqué
P
P
D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000134:cerebrospinal fluid; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D012995:Solubility
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I