MK801 antagonism of the prolonged depletion of striatal dopamine by amphetamine in iprindole-treated rats.
The administration of amphetamine to rats pretreated with iprindole to inhibit the metabolism of amphetamine results in a long-lasting depletion of striatal dopamine and its metabolites, DOPAC and HVA. Pretreatment with MK801, a noncompetitive antagonist of the NMDA (N-methyl-D-aspartate) subclass of excitatory amino acid receptors, antagonized the depletion of striatal dopamine, DOPAC and HVA 3 days after a single dose of amphetamine in iprindole-treated rats. MK801 pretreatment was effective up to 4 hours but not at 8 or 24 hours in preventing amphetamine effects on striatal dopamine, DOPAC and HVA.
Hemrick-Luecke
S K
SK
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, In 46285.
Henderson
M G
MG
Fuller
R W
RW
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000661:Amphetamine / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004298:Dopamine / Q000032:analysis / Q000378:metabolism* / Q000502:physiology; D006719:Homovanillic Acid / Q000378:metabolism; D007488:Iprindole / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D015102:3,4-Dihydroxyphenylacetic Acid; D007488:Iprindole; D016291:Dizocilpine Maleate; D000661:Amphetamine; D004298:Dopamine; D006719:Homovanillic Acid