title: Neuroblastoma with intracranial involvement: an ENSG Study.
abstract: We report the experience of the European Neuroblastoma Study Group (ENSG) with central nervous system (CNS) involvement of neuroblastoma. Among this series of intensively treated patients, CNS neuroblastoma was diagnosed by computerised tomography (CT) scanning, rather than by autopsy. Cranial disease occurred in 5% of ENSG patients. Of 11 patients with intracranial disease, 4 had disease in the posterior fossa, a site rarely reported previously. Furthermore, 5 cases had CNS metastases at a time when there was no detectable disease elsewhere, rather than as part of extensive relapse. The pattern of disease we observed, at least for those with parenchymal disease, is in keeping with arterial spread. Although CT scanning is the optimal modality for identifying CNS disease, 2 cases had normal head CT scans prior to the onset of CNS disease. As most patients had symptoms of raised intracranial pressure (RICP) at the time the CNS disease was diagnosed, there does not seem to be any indication for routine CT scanning of the head at diagnosis, but this should be performed as soon as any symptoms or signs appear. With patients living longer with their disease, vigilance must be maintained during follow-up.
authors.affiliation: Department of Paediatric Haematology, Royal Hospital for Sick Children, Edinburgh, Scotland.
authors.forename: P J
authors.initials: PJ
authors.lastname: Shaw
authors.forename: T
authors.initials: T
authors.lastname: Eden
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000556:secondary*; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003388:Cranial Fossa, Posterior; D003520:Cyclophosphamide / Q000008:administration & dosage; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy / Q000453:epidemiology* / Q000556:secondary*; D015995:Prevalence; D012042:Registries; D013713:Teniposide / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D013713:Teniposide; D002945:Cisplatin