New pharmacokinetic methods for the study of antiepileptic medications of the 1990s.
New methods that will be useful in the study of the pharmacokinetics of both new and established antiepileptic drugs include stable-isotope tracer techniques for studies of absorption, elimination, and drug interactions; the microperfusion technique and the staggered stable-isotope administration technique for the study of distribution; and the correction of trough drug serum concentration values to mean serum concentration values. New pharmacokinetic methods for a study of drugs with new and unique properties include a double stable-isotope technique to deal with the unique pharmacokinetic properties of prodrugs and techniques for describing the biologic half-life of drugs that have a high affinity for active sites.
Browne
T R
TR
Department of Neurology, Boston University School of Medicine, MA 02118.
Szabo
G K
GK
D000042:Absorption; D000927:Anticonvulsants / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry; D003956:Dialysis; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007553:Isotope Labeling; D010477:Perfusion; D010599:Pharmacokinetics
D000927:Anticonvulsants