title: The histiocytoses of childhood.
abstract: The histiocytoses of childhood include Langerhans' cell histiocytosis, haemophagocytic syndrome (familial and reactive), sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease), juvenile xanthogranuloma and malignant histiocytosis. These disorders show wide variation in their clinical presentation, prognosis and genetic implications. All are characterized by localized or generalized proliferation of histiocytes, but they differ in their morphology, histochemical and immunochemical staining patterns and electronmicroscopical features. On the basis of a comprehensive clinical history and critical interpretation of morphology and immunocytochemistry using an appropriately selected panel of antibodies, a diagnosis can be reached in the majority of cases.
authors.affiliation: Department of Histopathology, Hospitals for Sick Children, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Malone
mesh_terms: D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D015620:Histiocytic Disorders, Malignant / Q000175:diagnosis; D015614:Histiocytosis / Q000175:diagnosis / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D008854:Microscopy, Electron; D010586:Phagocytes / Q000473:pathology