title: Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis.
abstract: The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA.
authors.affiliation: Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229.
authors.forename: E H
authors.initials: EH
authors.lastname: Giannini
authors.forename: C N
authors.initials: CN
authors.lastname: Malagon
authors.forename: C
authors.initials: C
authors.lastname: Van Kerckhove
authors.forename: J
authors.initials: J
authors.lastname: Taylor
authors.forename: D J
authors.initials: DJ
authors.lastname: Lovell
authors.forename: J E
authors.initials: JE
authors.lastname: Levinson
authors.forename: M H
authors.initials: MH
authors.lastname: Passo
authors.forename: J
authors.initials: J
authors.lastname: Ginsberg
authors.forename: M J
authors.initials: MJ
authors.lastname: Burke
authors.forename: D N
authors.initials: DN
authors.lastname: Glass
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000502:physiology; D006801:Humans; D015863:Iridocyclitis / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D015993:Life Tables; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors
chemical_list: D000949:Histocompatibility Antigens Class II