[Interactions of neurotropic drugs with phosphatidylcholine bilayer. Effects on sorption of polyvalent cations].
It is found that neurotropic drugs, whose molecules have positively-charged amino groups and a considerable hydrophobic region (in size), can be incorporated into the phospholipid bilayers. This results in a decrease of the lifetime of Pr3+ cations in the membrane-associated state. No correlation was found to exist between local anaesthesia activity of the study drugs and its capability of displacement polyvalent cations from the membrane surface.
Burt
A Iu
AIu
Aksenov
S I
SI
D000779:Anesthetics, Local / Q000494:pharmacology*; D004347:Drug Interactions; D008051:Lipid Bilayers / Q000494:pharmacology*; D008081:Liposomes; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology*
D000779:Anesthetics, Local; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines
Vzaĭmodeistvie neĭrotropnykh preparatov s fosfatidilkholinovym bisloem. Vliianie na sorbtsiiu polivalentnykh kationov.