Beneficial effect of sodium sucrose-sulfate on the ocular surface of patients with severe KCS in primary Sjögren's syndrome.
Sucralfate (aluminium sucrose-sulfate), a well known gastric mucosal protectant, has been tested topically on 22 patients (20 females and 2 males) suffering from primary Sjögren's syndrome. Median treatment period was 6 months (range 1-19 months). Statistically significant improvement in the ocular surface condition was found judged from the reduction in Rose-Bengal score (P less than or equal to 0.00005). The beneficial effect appeared within the first 1-4 months of treatment. No adverse side effects were encountered.
Prause
J U
JU
Eye Pathology Institute, University of Copenhagen, Denmark.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D003315:Cornea / Q000473:pathology; D005260:Female; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012395:Rose Bengal; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy*; D013392:Sucralfate / Q000627:therapeutic use*; D013666:Tears / Q000378:metabolism
D012395:Rose Bengal; D013392:Sucralfate