title: Herpes simplex hepatitis in a patient with psoriatic arthritis taking prednisone and methotrexate. Report and review of the literature.
abstract: Herpes simplex hepatitis is a rare disease in adults and with high mortality (81%). Most cases are seen in immunocompromised hosts or in the third trimester of pregnancy. A 43-year-old woman with psoriatic arthritis, treated with prednisone and methotrexate (MTX), presented with an acute abdomen and elevated liver enzymes. The diagnosis was made by liver biopsy. MTX was stopped and acyclovir was started. The patient survived. The diagnosis of Herpes simplex should be suspected in immunocompromised hosts and established by liver biopsy and viral cultures. Treatment includes parenteral acyclovir and discontinuation or reduction of immunosuppressive therapy.
authors.affiliation: Department of Medicine and Pathology, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Aboguddah
authors.forename: H B
authors.initials: HB
authors.lastname: Stein
authors.forename: P
authors.initials: P
authors.lastname: Phillips
authors.forename: J
authors.initials: J
authors.lastname: Amar
authors.forename: R
authors.initials: R
authors.lastname: English
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D006561:Herpes Simplex; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011241:Prednisone; D008727:Methotrexate