[Anticerebellar antibodies--anti-Hu and anti-Yo--in the diagnosis of paraneoplastic neurologic syndromes].
The detection of antineuronal antibodies against cytoplasm and nuclei of Purkinje cells is considered to be an essential factor in the diagnosis of neurologic paraneoplastic syndromes. Published data rely on different immunological methods and relatively small numbers of patients. The clinical relevance of this phenomenon is not clear from the literature. A positive correlation between antibody detection and the appearance of neurologic paraneoplastic syndromes has been reported, but this finding has been questioned in critical reviews.
Grisold
W
W
Neurologische Abteilung, Kaiser Franz Josef Spital, Wien.
Drlicek
M
M
Liszka
U
U
D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D009363:Neoplasm Proteins / Q000276:immunology*; D009419:Nerve Tissue Proteins; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000276:immunology*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D001426:Bacterial Proteins; C063762:CDR1 protein, human; C095184:CDR2 protein, human; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C040330:histone-like protein HU, bacteria
Antizerebelläre Antikörper--Anti-Hu und Anti-Yo--in der Diagnostik paraneoplastischer neurologischer Syndrome.