Parvalbumin-positive neurons in rat dorsal hippocampus contain muscarinic acetylcholine receptors.
The present study describes the colocalization of muscarinic acetylcholine receptors (mAChRs) and the calcium-binding protein parvalbumin (PARV) in nonpyramidal neurons of the rat dorsal hippocampus by means of dual-label immunocytochemistry. Fifty-two percent of all muscarinic cholinoceptive nonpyramidal neurons contain parvalbumin. Conversely, the vast majority (88.4%) of all PARVergic neurons possess mAChRs. The PARVergic neurons embedded within the CA1 pyramidal cell layer are nearly all (98.9%) immunopositive for mAChRs. These results indicate that the cholinergic septohippocampal projection represents a major afferent system upon the inhibitory PARVergic neurons.
van der Zee
E A
EA
Department of Animal Physiology, University of Groningen, The Netherlands.
de Jong
G I
GI
Strosberg
A D
AD
Luiten
P G
PG
D000818:Animals; D005455:Fluorescent Antibody Technique; D006624:Hippocampus / Q000166:cytology*; D008297:Male; D009474:Neurons / Q000166:cytology*; D010320:Parvalbumins / Q000032:analysis*; D011712:Pyramidal Tracts / Q000166:cytology; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000032:analysis*
D010320:Parvalbumins; D011976:Receptors, Muscarinic