Flumazenil for the reversal of refractory benzodiazepine-induced shock.
Benzodiazepines are known to cause central nervous system and centrally mediated cardiovascular depression. The benzodiazepine antagonist flumazenil has been shown to antagonize benzodiazepine-induced central nervous system depression. We report a case in which cardiovascular depression secondary to benzodiazepine use was reversed by this agent.
Coates
W
W
Division of Emergency Medicine, Allegheny General Hospital, Pittsburgh, PA 15212.
Evans
T C
TC
Jehle
D
D
Harchelroad
F
F
Isaacs
M
M
D000368:Aged; D002319:Cardiovascular System / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D003975:Diazepam / Q000009:adverse effects* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005260:Female; D005442:Flumazenil / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D012119:Respiration / Q000187:drug effects; D012769:Shock / Q000139:chemically induced* / Q000188:drug therapy
D005442:Flumazenil; D003975:Diazepam