title: [Interactions of neurotropic drugs with phosphatidylcholine bilayer. Effects on sorption of polyvalent cations].
abstract: It is found that neurotropic drugs, whose molecules have positively-charged amino groups and a considerable hydrophobic region (in size), can be incorporated into the phospholipid bilayers. This results in a decrease of the lifetime of Pr3+ cations in the membrane-associated state. No correlation was found to exist between local anaesthesia activity of the study drugs and its capability of displacement polyvalent cations from the membrane surface.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Burt
authors.forename: S I
authors.initials: SI
authors.lastname: Aksenov
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D004347:Drug Interactions; D008051:Lipid Bilayers / Q000494:pharmacology*; D008081:Liposomes; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines
vernacular_title: Vzaĭmodeistvie neĭrotropnykh preparatov s fosfatidilkholinovym bisloem. Vliianie na sorbtsiiu polivalentnykh kationov.