title: Evaluation of the improvement of cephems on the prophylaxis of pelvic infection after radical hysterectomy.
abstract: Antibiotics, especially cephems, have been improved remarkably in the last 20 years. In order to evaluate the improvement of antibiotics used for the prophylaxis of infections after radical hysterectomy, two groups of patients (group A, 1978-1979, n = 54; group B, 1985-1987, n = 55) were examined in regard to bacteriological and clinical effects. In spite of the improvement of antibiotics, the positive rate of bacteriological analysis had increased from 44.4 to 76.4%. Obvious decrease of gram-negative bacilli and increase of gram-positive cocci (GPC), e.g. Enterococcus, were observed. In contrast, fever index and febrile morbidity of group B decreased significantly more than those of group A. These results indicate that the improvement of antibiotics has brought more effective prophylaxis in the postoperative infection in spite of the high positive rate of GPC.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kobamatsu
authors.forename: S
authors.initials: S
authors.lastname: Makinoda
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: J
authors.initials: J
authors.lastname: Tamaki
authors.forename: T
authors.initials: T
authors.lastname: Okuda
authors.forename: N
authors.initials: N
authors.lastname: Sakuragi
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Fujimoto
mesh_terms: D002511:Cephalosporins / Q000627:therapeutic use*; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology / Q000517:prevention & control*; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007044:Hysterectomy; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D000292:Pelvic Inflammatory Disease / Q000453:epidemiology / Q000517:prevention & control*; D011292:Premedication; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D002511:Cephalosporins