Disseminated histiocytosis with undetermined Langerhans' cells simulating an acute non lymphoid leukemia.
The authors report on a case of disseminated Langerhans' cell histiocytosis with a clinical presentation and a bone marrow simulating, at onset, an acute leukemia non lymphoid. A hepatic needle biopsy performed for the progressive enlargement of the liver oriented the diagnosis towards a Langerhans' cell histiocytosis. The morphological, immunohistochemical and ultrastructural study of these cells showed them to be undetermined, i.e. Langerhans' cell precursors.
Miano
C
C
Divisione di Ematologia Pediatrica, Ospedale Bambino Gesù, Roma, Italy.
Bosman
C
C
Boldrini
R
R
DonFrancesco
A
A
Ceci
A
A
Mancini
S
S
Rosati
D
D
D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007223:Infant; D007801:Langerhans Cells / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis*; D008099:Liver / Q000473:pathology