Splenic hamartoma and capillary hemangioma are distinct entities: immunohistochemical analysis of CD8 expression by endothelial cells.
The histologic and immunohistologic features of two morphologically similar splenic tumors, a capillary hemangioma and a splenic hamartoma, are reported. The hemangioma was composed predominantly of small vascular channels lined by endothelium expressing factor VIII-related antigen and lacking T-subset antigen (CD8). In contrast, the splenic hamartoma was predominantly a spindle cell lesion with numerous vascular channels coursing through the tumor; these contained splenic-type endothelium expressing both CD8 and factor VIII-related antigen. Our results justify the concept that the splenic hamartoma is a tumor of splenic origin or a true hamartoma and is distinct from the splenic capillary hemangioma.
Zukerberg
L R
LR
James Homer Wright Pathology Laboratory, Massachusetts General Hospital, Boston 02114.
Kaynor
B L
BL
Silverman
M L
ML
Harris
N L
NL
D000368:Aged; D016827:CD8 Antigens / Q000032:analysis*; D004727:Endothelium / Q000276:immunology; D004730:Endothelium, Vascular / Q000276:immunology; D005260:Female; D006222:Hamartoma / Q000098:blood supply / Q000276:immunology* / Q000473:pathology; D006391:Hemangioma / Q000098:blood supply / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000098:blood supply* / Q000276:immunology* / Q000473:pathology; D014841:von Willebrand Factor / Q000032:analysis
D016827:CD8 Antigens; D014841:von Willebrand Factor