title: Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.
abstract: The results of a randomised double-blind clinical trial of 0.1% bromovinyldeoxyuridine (BVDU) and 1% trifluorothymidine (TFT) in 60 patients with corneal dendritic ulceration are presented. There was no significant difference between BVDU and TFT in terms of numbers of ulcers healed (p = 0.61), mean healing time (p = 0.065), and cumulative healing rate (p = 0.058). No serious side effects were observed, though transient stinging was recorded in five patients receiving TFT and in three patients receiving BVDU. One patient in the group treated with TFT developed a punctate epitheliopathy.
authors.affiliation: Professorial Unit, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
authors.forename: W J
authors.initials: WJ
authors.lastname: Power
authors.forename: A
authors.initials: A
authors.lastname: Benedict-Smith
authors.forename: M
authors.initials: M
authors.lastname: Hillery
authors.forename: K
authors.initials: K
authors.lastname: Brady
authors.forename: L M
authors.initials: LM
authors.lastname: Collum
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D003320:Corneal Ulcer / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014271:Trifluridine / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; C020235:brivudine; D001973:Bromodeoxyuridine; D014271:Trifluridine