title: Activation of mononuclear immune cells in response to staphylococcal lipoteichoic acid.
abstract: The goal of the present study was to evaluate the influence of staphylococcal lipoteichoic acid (LTA) on the activation of mononuclear immune cells. A murine tumor necrosis-like factor (TNF-like) was induced in the sera of CD-1 mice which had been primed with heat/formalin-inactivated Propionibacterium avidum KP-40 and subsequently exposed to LTA extracted from Staphylococcus saprophyticus strain S 1. Monoclonal antibody against murine TNF (anti-TNF) significantly inhibited the cytostatic activity of mice sera against transformed L-929 cells. Freshly isolated lymphocytes did not display interleukin 2 (Il-2) receptors, but receptors were expressed on Con A incubated cells and in significantly higher numbers after coexposure to staphylococcal LTA in vitro. Since the induction of TNF (macrophages) and Il-2 receptors (lymphocytes) represent stimulation of the mononuclear immune system, staphylococcal LTA may be considered to be an immunomodifier.
authors.affiliation: Department of Microbiology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohshima
authors.forename: H L
authors.initials: HL
authors.lastname: Ko
authors.forename: J
authors.initials: J
authors.lastname: Beuth
authors.forename: H
authors.initials: H
authors.lastname: Burrichter
authors.forename: K
authors.initials: K
authors.lastname: Oette
authors.forename: G
authors.initials: G
authors.lastname: Pulverer
mesh_terms: D000818:Animals; D005260:Female; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis; D013210:Staphylococcus / Q000276:immunology*; D013682:Teichoic Acids / Q000276:immunology*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D008070:Lipopolysaccharides; D015375:Receptors, Interleukin-2; D013682:Teichoic Acids; D014409:Tumor Necrosis Factor-alpha; C009900:lipoteichoic acid