Pericentric inversion of chromosome 5: a possible threat to male fertility?
Pericentric inversion of chromosome 5 (inv(5)(p12,q13] was diagnosed in two unrelated men with normal phenotype referred for infertility. The spermatogenic damage in these patients may be explained on the basis of the X-Y bivalent behaviour in cases of some balanced structural rearrangements of the chromosomes. The Authors propose a possible negative action of inv(5) in male gamete production and suggest a larger use of the chromosome analysis in the study of male infertility.
Simi
P
P
Laboratorio di Citogenetica, Università di Pisa, Italy.
Voliani
S
S
Rossi
S
S
Olivieri
L
L
Menchini Fabris
F
F
D000328:Adult; D007446:Chromosome Inversion; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic