title: Effects of pimozide on the hedonic properties of sucrose: analysis by the taste reactivity test.
abstract: The ability of the neuroleptic agent, pimozide, to modify sucrose palatability was assessed using three 10-min taste reactivity test sessions. Pimozide was found to suppress the ingestive response of tongue protrusions, but enhance the mildly ingestive/neutral response of mouth movements elicited by an intraoral infusion of sucrose solution. Since the pattern of taste reactivity responding shifted from highly ingestive to mildly ingestive/neutral, our results suggest that pimozide pretreatment reduces the palatability of sucrose solution. The temporal pattern of the modification of these taste reactivity responses was predicted by the Anhedonia Hypothesis.
authors.affiliation: Psychology Department, Wilfrid Laurier University, Waterloo, Ontario, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Leeb
authors.forename: L
authors.initials: L
authors.lastname: Parker
authors.forename: R
authors.initials: R
authors.lastname: Eikelboom
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009055:Mouth / Q000502:physiology; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000494:pharmacology*; D013649:Taste / Q000187:drug effects*; D014059:Tongue / Q000502:physiology
chemical_list: D010868:Pimozide; D013395:Sucrose