title: The effect of tranexamic acid on bleeding time and haemostasis.
abstract: The effect of tranexamic acid (TXA) on platelet function was examined in 37 patients with ruptured intracranial aneurysms. TXA was administered in a double-blind, placebo controlled manner to 37 patients with ruptured intracranial aneurysms. TXA was given to 17 patients in a dose of 9 g/24 hours, to another 6 patients in a dose of 6 g/24 hours; 14 patients were given a placebo. The effect of TXA on certain haemostatic function tests was evaluated between the treatment groups. We conclude that patients receiving TXA do not appear to be at risk of recurrent haemorrhage due to abnormal haemostasis.
authors.affiliation: University Department of Neurosurgery and Haematology, Midland Centre for Neurosurgery and Neurology, Birmingham, England.
authors.forename: S A
authors.initials: SA
authors.lastname: Menzies
authors.forename: J A
authors.initials: JA
authors.lastname: Hartley
authors.forename: E R
authors.initials: ER
authors.lastname: Hitchcock
authors.forename: E
authors.initials: E
authors.lastname: Rorke
authors.forename: J S
authors.initials: JS
authors.lastname: Gill
mesh_terms: D001760:Bleeding Time; D001780:Blood Coagulation Tests; D004334:Drug Administration Schedule; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D002532:Intracranial Aneurysm / Q000097:blood / Q000188:drug therapy*; D010973:Platelet Adhesiveness / Q000187:drug effects / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010976:Platelet Count / Q000187:drug effects; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000188:drug therapy*; D014148:Tranexamic Acid / Q000008:administration & dosage*
chemical_list: D014148:Tranexamic Acid