title: Nonsuture closure of arterial defect by vein graft using isobutyl-2-cyanoacrylate as a tissue adhesive.
abstract: Nonsuture repair of intracranial blood vessel is still a challenging issue in neurosurgery. In this experimental study isobutyl-2-cyanoacrylate was used for nonsuture repairing of carotid artery to observe its histotoxicity. Isobutyl-2-cyanoacrylate was dropped over the edge of defect on carotid artery of rat under the surgical microscope and jugular vein was placed to cover the defect. Rats were divided in 6 group according to postoperative survival period (2, 5, 7, 14, 21, 28 days respectively). The carotid arteries were patent of all rats according to angiography and autopsy specimen. Histopathological results showed that: the changes are mainly inflammatory respons +, there was no necrotic tissue at any time the healing progress and no significant differences in the vein graft. Therefore isobutyl-2-cyanoacrylate is considered helpful and safe adhesive material for the nonsuture repair of blood vessel.
authors.affiliation: Department of Neurosurgery, School of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: H
authors.initials: H
authors.lastname: Celik
authors.forename: H
authors.initials: H
authors.lastname: Caner
authors.forename: K
authors.initials: K
authors.lastname: Tahta
authors.forename: O E
authors.initials: OE
authors.lastname: Ozcan
authors.forename: A
authors.initials: A
authors.lastname: Erbengi
authors.forename: B
authors.initials: B
authors.lastname: Onol
mesh_terms: D000818:Animals; D002015:Bucrylate; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery*; D007249:Inflammation; D007601:Jugular Veins / Q000473:pathology / Q000637:transplantation*; D051381:Rats; D014656:Vascular Surgical Procedures / Q000379:methods; D014945:Wound Healing
chemical_list: D002015:Bucrylate