title: Vaginal absorption of low-dose tranexamic acid from impregnated tampons.
abstract: Tranexamic acid (TA), an antifibrinolytic drug, is usually administered orally to women with menorrhagia. This route of administration is associated with adverse side-effects, therefore tampons impregnated with TA were used to assess the absorption of the drug across the vaginal epithelium. Blood levels of TA in group A (9 patients), who had one tampon inserted, and group B (10 patients), who had a tampon inserted at 2-hourly intervals so that a total of 3 tampons were administered over a 6-hour period, demonstrated absorption of the drug into the blood stream in low concentrations.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Natal.
authors.forename: J
authors.initials: J
authors.lastname: Moodley
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.forename: K
authors.initials: K
authors.lastname: Devraj
authors.forename: M
authors.initials: M
authors.lastname: Dutton
mesh_terms: D000042:Absorption; D000328:Adult; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000188:drug therapy*; D013630:Tampons, Surgical; D014148:Tranexamic Acid / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D014621:Vagina / Q000378:metabolism*
chemical_list: D014148:Tranexamic Acid