title: Ofloxacin during the second trimester of pregnancy.
abstract: Ofloxacin can cause retarded ossification and arthropathy in young animals, but there is no published information about its teratogenicity in humans. A 36-year-old woman was treated with ofloxacin 200 mg bid for 6 days during the 19th week of gestation. Ultrasound follow-up of the measurements and structure of the fetal long bones revealed no abnormalities. The neonate's physical examination and X-rays of the chest and long bones were normal. Although no teratogenic or toxic effects were observed in this patient, the use of ofloxacin in human pregnancy should only be a clinical consideration until sufficient evidence regarding its safety in the human fetus has been published.
authors.affiliation: Neonatal Department, Beilinson Medical Center, Petah Tiqva, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Peled
authors.forename: S
authors.initials: S
authors.lastname: Friedman
authors.forename: M
authors.initials: M
authors.lastname: Hod
authors.forename: P
authors.initials: P
authors.lastname: Merlob
mesh_terms: D000328:Adult; D002358:Cartilage, Articular / Q000000981:diagnostic imaging / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D015242:Ofloxacin / Q000627:therapeutic use*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000187:drug effects*; D016216:Ultrasonography, Prenatal; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D015242:Ofloxacin