title: Early postoperative myocardial morbidity in patients with coronary artery disease undergoing major non-cardiac surgery: correlation with perioperative ischaemia.
abstract: As a part of a study assessing early postoperative myocardial morbidity in 50 patients with active coronary artery disease undergoing major non-cardiac surgery, the ECG was monitored continuously for 24 hr after the onset of anaesthesia, using a frequency modulated (FM) Holter monitor. Concurrent automated blood pressure and pulse were measured non-invasively at three-minute intervals during anaesthesia and subsequently at five-minute intervals. Thirty patients were monitored with two-site ECG recordings, from modified V1 and V5 (Group A). Twenty patients had seventeen-site ECG monitoring, multiplexing a four by four array of precordial electrodes onto one channel of the frequency modulated recorder (Group B). Tapes were analyzed for noise, supraventricular and ventricular dysrythmias, runs of tachy- and bradycardia, and ST segment changes. These data were correlated with serial standard 12-lead ECGs and CK-MB assay in the 72 hr after surgery. Seven tapes from Group A could not be analyzed. Change (greater than 1 mm) on ST monitoring from both Groups A (14/23), B (14/20), correlated with serial 12-lead ECG and/or CK-MB changes. The majority of first ST change 19/28 (70%) occurred after anaesthesia. In 14/28 (50%) ST change occurred during episodes of tachycardia and elevated blood pressure (greater than 20% above baseline). Nine patients (9/23) in Group A had no ST change; however, six had serial 12-lead ECG and/or CK-MB changes. Six patients (6/20) in Group B had no ST changes, and none of these patients had any change of serial 12-lead ECGs or CK-MB assay. No patient complained of chest pain during the Holter monitoring period. Continual monitoring of heart rate and blood pressure and accurate ST monitoring are essential to detect and treat perioperative myocardial ischemia. A multiple-lead precordial system is substantially more sensitive than traditional two-lead ECG holter monitoring in detecting myocardial ischaemia.
authors.affiliation: Department of Anaesthesia, University of Southampton.
authors.forename: R D
authors.initials: RD
authors.lastname: Seegobin
authors.forename: T H
authors.initials: TH
authors.lastname: Wilmshurst
authors.forename: J
authors.initials: J
authors.lastname: Johnston
authors.forename: F
authors.initials: F
authors.lastname: Clewlow
authors.forename: A
authors.initials: A
authors.lastname: Murrills
authors.forename: A H
authors.initials: AH
authors.lastname: Seegobin
authors.forename: F
authors.initials: F
authors.lastname: Goodland
authors.forename: C
authors.initials: C
authors.lastname: Wainwright
authors.forename: J
authors.initials: J
authors.lastname: Norman
authors.forename: N
authors.initials: N
authors.lastname: Conway
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology; D001794:Blood Pressure / Q000502:physiology; D003327:Coronary Disease / Q000150:complications* / Q000209:etiology* / Q000503:physiopathology; D003402:Creatine Kinase / Q000097:blood; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007431:Intraoperative Complications; D007527:Isoenzymes; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications; D013514:Surgical Procedures, Operative; D015996:Survival Rate; D013997:Time Factors
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase