title: NMR studies of aureobasidins A and E.
abstract: The 1H and 13C NMR spectra of aureobasidins A and E were analyzed by a variety of 2D NMR techniques. Two isomers of aureobasidin A existed as an equilibrium mixture in deuteriochloroform. The isomerism was associated with cis-trans rotation of the amide bond between N-methylphenylalanine and proline. Almost all of the aureobasidin E was found in deuteriochloroform as one conformer; the amide bond between beta-hydroxy-N-methylphenylalanine and proline was in the cis-conformation. Experiments with the NOE made identification of the conformation of the amide bonds of aureobasidins A and E possible.
authors.affiliation: Biotechnology Research Laboratories, Takara Shuzo Co., Ltd., Shiga, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ikai
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: K
authors.initials: K
authors.lastname: Takesako
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
mesh_terms: D000595:Amino Acid Sequence; D000935:Antifungal Agents / Q000737:chemistry*; D047630:Depsipeptides; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C071398:aureobasidin A; C072154:aureobasidin E