title: Comparison of an extraaortic counterpulsation device versus intraaortic balloon pumping in severe cardiac failure.
abstract: A valveless, single orifice polyurethane ventricle was implanted on the brachiocephalic artery in sheep (n = 14) to provide extraaortic counterpulsation. In parallel, an intraaortic balloon was placed in the descending thoracic aorta. Both devices were pneumatically driven by a standard intraaortic balloon pump (IABP) console at a preload of 40 cc. Severe cardiac failure was induced with high dosages of esmolol. Measured parameters were aortic pressure (PA) and flow (QA), coronary flow (QC), and left ventricular pressure (PLV). Tension time index (TTI), total QA and QC, and end-diastolic aortic pressure (EDP) were computed to compare the efficacy of counterpulsation between assisted and unassisted conditions. Three conditions of inflation/deflation timing were examined: Normal timing (NT), early inflation (EI), and late deflation (LD). Results indicated that extraaortic counterpulsation device actuation yielded statistically significant increases in QC, and significant decreases in EDP and TTI for all timing conditions examined, when compared with unassisted conditions. Flow was significantly increased only for EI and NT timing conditions. Counterpulsation delivered with IABP yielded statistically significant increases in EDP for LD timing, and significant decreases in TTI for NT only. These results indicate that EACD is much less dependent on inflation/deflation timing when compared with IABP. The extraaortic counterpulsation device consistently increases QC and decreases TTI, which enhances the oxygen supply/consumption ratio (S/C) of the left ventricle. The intraaortic balloon pump does not significantly increase S/C in severe cardiac failure, and will increase afterload if deflation timing is not properly set.
authors.affiliation: Department of Surgery, New York Hospital-Cornell Medical Center, New York 10021.
authors.forename: J A
authors.initials: JA
authors.lastname: Zelano
authors.forename: W
authors.initials: W
authors.lastname: Ko
authors.forename: R
authors.initials: R
authors.lastname: Lazzaro
authors.forename: W D
authors.initials: WD
authors.lastname: Lazenby
authors.forename: S
authors.initials: S
authors.lastname: Topaz
authors.forename: W J
authors.initials: WJ
authors.lastname: Kolff
authors.forename: O W
authors.initials: OW
authors.lastname: Isom
authors.forename: K H
authors.initials: KH
authors.lastname: Krieger
mesh_terms: D000818:Animals; D015908:Counterpulsation / Q000295:instrumentation*; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006439:Hemodynamics / Q000502:physiology*; D007423:Intra-Aortic Balloon Pumping / Q000295:instrumentation*; D012756:Sheep