title: Pharmacokinetics of oral salbutamol controlled-release in Asian patients with asthma.
abstract: Using a double blind, double dummy crossover design, single dose and steady state pharmacokinetics of oral controlled release (SCR) salbutamol 4 mg and 8 mg tablets b.d. has been studied in 8 Asian patients. Plasma salbutamol was measured over 12 h. In 8 patients the single dose mean Cmax was 4.2 ng.ml-1 and 7.7 ng.ml-1 after 4 and 8 mg, respectively. In 5 patients the steady state mean Cmax, Cmin and tmax were 8.1 ng.ml-1 and 4.7 ng.ml-1 and 6 h for the 4 mg tablets and 14.1 ng.ml-1 and 7.1 ng.ml-1 and 4 h for the 8 mg tablets. It is concluded that both doses of SCR show features of controlled release and that they produced a relatively constant plasma level of salbutamol in Asian patients.
authors.affiliation: Department of Medicine, National University of Singapore.
authors.forename: W C
authors.initials: WC
authors.lastname: Tan
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage / Q000493:pharmacokinetics*; D044466:Asian People; D001249:Asthma / Q000378:metabolism*; D003692:Delayed-Action Preparations; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D003692:Delayed-Action Preparations; D000420:Albuterol