Incompatibility of water-soluble contrast media and intravascular pharmacologic agents. An in vitro study.
In vitro incompatibilities between nine water-soluble contrast media and 21 intravascular pharmacologic agents were investigated using naked-eye observation and a centrifuge. Most of the previously reported incompatibilities were verified, and a few new incompatibilities were discovered: phentolamine mesylate with diatrizoate sodium, diatrizoate meglumine, ioxaglate, and iothalamate; diatrizoate meglumine with diazepam and meperidine hydrochloride; and diatrizoate sodium with meperidine hydrochloride. There were no incompatibilities when the pharmacologic agents investigated were mixed with ioxithalamate, iopromide, iopamidol, and iohexol.
Kim
S H
SH
Department of Diagnostic Radiology, Seoul National University College of Medicine, Republic of Korea.
Lee
H K
HK
Han
M C
MC
D001808:Blood Vessels; D003287:Contrast Media; D004347:Drug Interactions; D066298:In Vitro Techniques; D004364:Pharmaceutical Preparations / Q000008:administration & dosage
D003287:Contrast Media; D004364:Pharmaceutical Preparations