title: Gastrocystoplasty in children.
abstract: We report our experience of gastrocystoplasty in 8 children (mean age 10.1 years) with compromised renal function (mean creatinine 186 mmol/l, mean glomerular filtration rate 39 ml/min/1.73 m2). Current follow-up ranges from 11 to 35 months (mean 21). The physiological outcome of the procedure has been excellent, with improved biochemical and urodynamic parameters in all cases. Six patients are off H2-receptor blockers and are asymptomatic. In 2 children we have encountered significant symptoms related to acid secretion in the bladder. Detailed investigations suggest that the excess aciduria is related to the size of the gastric patch in 1 patient. The second child underwent renal transplantation 5 months after gastrocystoplasty and it is postulated that his immunosuppressive regimen (which includes prednisolone) may be responsible for the increased acid secretion. It is concluded that gastrocystoplasty is a very satisfactory alternative to intestinal segment bladder enhancement in children with compromised renal function, but the size of the gastric patch is critical in determining the resultant acid secretion. Post-transplantation immunosuppressive therapy may increase acid production from the gastric patch; since the children most suitable for gastrocystoplasty are also those likley to require transplantation, this aspect requires further study.
authors.affiliation: Department of Paediatric Urology, Hospital for Sick Children, London.
authors.forename: E H
authors.initials: EH
authors.lastname: Dykes
authors.forename: P G
authors.initials: PG
authors.lastname: Ransley
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D013270:Stomach / Q000637:transplantation*; D001743:Urinary Bladder / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics
chemical_list: D005755:Gastrins