Clinical experience with the adrenal scanning agents iodine 131-19-iodocholesterol and selenium 75-6-selenomethylcholesterol.
Adrenocortical scintigraphy with iodine 131-19-iodocholesterol or selenium 75-6-selenomethylcholesterol was performed in 94 patients with proven or suspected adrenal disease. According to the final diagnosis, 36 patients suffered from primary aldosteronism, 33 from Cushing's syndrome, 8 from low renin hypertension, 6 from nonfunctioning adrenal tumour, 4 from simple obesity, 3 from adrenal metastases, 1 from congenital adrenal hyperplasia, 1 from virilizing adrenal adenoma, 1 from extraadrenal phaeochromocytoma, 1 from ganglioneuroma. Surgical confirmation of the diagnosis was obtained in most cases. With a few exceptions, the scintigraphy results were consistent with the final diagnosis. The two tracers were equally effective adrenal scanning agents. Tracer concentration was measured in a number of surgical specimens, mostly from patients given selenocholesterol. This measurement in surgical samples has not been reported in previous studies with this agent. The results provided a direct validation of uptake measurements in vivo. The data, collected over a 17-year period, demonstrate that despite the advent of new imaging techniques, adrenal scintigraphy that gives both functional and morphologic information still has an important role in the diagnosis of adrenal disease.
Reschini
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Department of Nuclear Medicine, Ospedale Maggiore di Milano, Italy.
Catania
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D015071:19-Iodocholesterol; D000307:Adrenal Gland Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology; D002784:Cholesterol / Q000031:analogs & derivatives*; D003480:Cushing Syndrome / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D006929:Hyperaldosteronism / Q000000981:diagnostic imaging / Q000453:epidemiology; D007457:Iodine Radioisotopes; D016566:Organoselenium Compounds; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012643:Selenium; D012644:Selenium Radioisotopes
D007457:Iodine Radioisotopes; D016566:Organoselenium Compounds; D012644:Selenium Radioisotopes; C045082:6-selenomethylcholesterol; D015071:19-Iodocholesterol; D002784:Cholesterol; D012643:Selenium