Ejaculations induced by p-chloroamphetamine (PCA) in rats, hamsters and mice.
The ejaculatory response induced by p-chloroamphetamine (PCA) in male rats, hamsters and mice was observed during 2 hours after the injection. The animals were treated intraperitoneally with PCA at doses ranging from 0.78125 to 160 mg/kg. The ED50 (effective dose in 50% of animals) values of PCA for the initiation of ejaculation in rats and hamsters were 1.3397 (1.0732-1.6725) and 0.1105 (0.0802-0.1522) mg/kg, respectively. On the other hand, no ejaculation was observed in any mice at any doses examined. So we concluded that there are species differences in the ejaculatory response, induced by PCA, among rats, hamsters and mice.
Saito
T R
TR
Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Aoki
S
S
Shutoh
Y
Y
Hokao
R
R
Sasaki
Y
Y
Amao
H
H
Wakafuji
Y
Y
Sugiyama
M
M
Takahashi
K W
KW
D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004542:Ejaculation / Q000187:drug effects*; D008297:Male; D008647:Mesocricetus / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D013045:Species Specificity; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D012701:Serotonin; D010133:p-Chloroamphetamine