title: Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
abstract: Linkage of at least two complementation groups of ataxia-telangiectasia (AT) to the chromosomal region 11q23 is now well established. We provide here an 18-point map of the surrounding genomic region, derived from linkage analysis of 40 CEPH families. On the basis of this map, 111 AT families from Turkey, Israel, England, Italy, and the United States were analyzed, localizing the AT gene(s) to an 8-cM sex-averaged interval between the markers STMY and D11S132/NCAM. A new Monte Carlo method for computing approximate location scores estimates this location as being at least 10(8) times more likely than the next most likely interval, with a support interval midway between STMY and D11S132 that is either 5.2 cM (sex-averaged and conservatively based on 3 lod scores from the maximum-location score) or 2.8 cM (male specific, based on a 2.72:1 interval-specific female-to-male distance ratio.
authors.affiliation: Department of Biomathematics, University of California School of Medicine, Los Angeles 90024.
authors.forename: T
authors.initials: T
authors.lastname: Foroud
authors.forename: S
authors.initials: S
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Ziv
authors.forename: E
authors.initials: E
authors.lastname: Sobel
authors.forename: E
authors.initials: E
authors.lastname: Lange
authors.forename: A
authors.initials: A
authors.lastname: Chao
authors.forename: T
authors.initials: T
authors.lastname: Goradia
authors.forename: Y
authors.initials: Y
authors.lastname: Huo
authors.forename: A
authors.initials: A
authors.lastname: Tolun
authors.forename: L
authors.initials: L
authors.lastname: Chessa
authors.forename: P
authors.initials: P
authors.lastname: Charmley
authors.forename: O
authors.initials: O
authors.lastname: Sanal
authors.forename: N
authors.initials: N
authors.lastname: Salman
authors.forename: C
authors.initials: C
authors.lastname: Julier
authors.forename: P
authors.initials: P
authors.lastname: Concannon
authors.forename: C
authors.initials: C
authors.lastname: McConville
authors.forename: A M
authors.initials: AM
authors.lastname: Taylor
authors.forename: Y
authors.initials: Y
authors.lastname: Shiloh
authors.forename: S K
authors.initials: SK
authors.lastname: Lange
authors.forename: R A
authors.initials: RA
authors.lastname: Gatti
mesh_terms: D001260:Ataxia Telangiectasia / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods; D002880:Chromosomes, Human, Pair 11; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D007391:International Cooperation; D008297:Male; D009010:Monte Carlo Method; D011110:Polymorphism, Genetic; D012737:Sex Factors
chemical_list: D005819:Genetic Markers