title: Fluoride, calcium and inorganic phosphorus concentrations in approximal plaque collected from young adults 1 and 24 h after toothbrushing with fluoride toothpastes.
abstract: A within-subject double-blind cross-over study was carried out to examine whether the chemical composition of approximal plaque was altered 1 and 24 h after brushing with fluoride toothpaste. Three fluoride toothpastes were tested, containing either sodium monofluorophosphate with calcium glycerophosphate supplement and calcium carbonate abrasive, a combination of sodium monofluorophosphate and sodium fluoride with the same supplement and abrasive or sodium fluoride with a silica abrasive. A fluoride-free toothpaste with a silica abrasive acted as the control. 19 subjects used the toothpastes separately in randomised order for 1 week each prior to collection of plaque. Contralateral half-mouth approximal plaque samples were collected 1 and 24 h after the last use of each toothpaste. Fluoride, calcium and inorganic phosphorus concentrations of plaque were estimated. The results indicated that brushing with toothpastes containing fluoride and/or calcium supplements resulted in increased concentrations of these constituents in approximal plaque 1 h after brushing. These elevated levels of inorganic ions were not observed in the samples collected 24 h after brushing. It was concluded that the potentially beneficial effect of a raised concentration of fluoride and calcium in approximal plaque observed soon after brushing is lost during the following 24 h.
authors.affiliation: Guy's Hospital Dental School, London, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Sidi
authors.forename: R F
authors.initials: RF
authors.lastname: Wilson
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002118:Calcium / Q000032:analysis; D003773:Dental Plaque / Q000737:chemistry*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000032:analysis* / Q000627:therapeutic use; D005460:Fluorides, Topical / Q000627:therapeutic use*; D005994:Glycerophosphates / Q000627:therapeutic use; D006801:Humans; D008297:Male; D010710:Phosphates / Q000032:analysis* / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D013997:Time Factors; D014100:Toothpastes / Q000627:therapeutic use*
chemical_list: D005460:Fluorides, Topical; D005994:Glycerophosphates; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides; D002118:Calcium