title: (Patho)physiological implications of chronic dietary sodium restriction during pregnancy; a longitudinal prospective randomized study.
abstract: OBJECTIVE
  To study the possible pathophysiological implications of long continued dietary sodium restriction in pregnancy.
  
  
  METHODS
  Longitudinal prospective randomized study of the effects of a low sodium diet compared with unrestricted sodium intake in pregnancy.
  
  
  METHODS
  Academic Department of Obstetrics and Gynaecology at Sint Radboud Hospital, Nijmegen, The Netherlands.
  
  
  METHODS
  42 healthy nulliparous women.
  
  
  METHODS
  A low sodium diet (20 mmol sodium daily) started in the 14th week of pregnancy and stopped after delivery.
  
  
  METHODS
  Maternal weight gain, food intake, blood pressure, cardiac output, systemic vascular resistance, haematocrit and birthweight.
  
  
  RESULTS
  Total maternal weight gain and dietary energy intake during pregnancy and weight at 1 and 6 weeks postpartum were significantly lower in the low sodium group. Blood pressure during pregnancy did not show major differences. Stroke volume and cardiac output during pregnancy were significantly lower in the low sodium group whereas systemic vascular resistance was significantly higher. Haematocrit values in the low sodium group tended to be lower during pregnancy, but were significantly lower at 1 and 6 weeks postpartum than in the unrestricted group. Placental and birthweights were not significantly different between the two groups.
  
  
  CONCLUSIONS
  Chronic dietary sodium restriction during pregnancy is characterized by a diminished body fat accumulation and a reduction in circulating volume, due to a decrease in both plasma and red cell volume, in combination with a high systemic vascular resistance without major effects on blood pressure and birthweight.
authors.affiliation: Department of Obstetrics and Gynaecology, Catholic University of Nijmegen, Sint Radboud Hospital, The Netherlands.
authors.forename: E A
authors.initials: EA
authors.lastname: Steegers
authors.forename: H P
authors.initials: HP
authors.lastname: Van Lakwijk
authors.forename: H W
authors.initials: HW
authors.lastname: Jongsma
authors.forename: J H
authors.initials: JH
authors.lastname: Fast
authors.forename: T
authors.initials: T
authors.lastname: De Boo
authors.forename: T K
authors.initials: TK
authors.lastname: Eskes
authors.forename: P R
authors.initials: PR
authors.lastname: Hein
mesh_terms: D001724:Birth Weight; D004435:Eating; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008137:Longitudinal Studies; D010298:Parity; D011247:Pregnancy / Q000502:physiology*; D011256:Pregnancy Outcome; D011897:Random Allocation; D012982:Sodium, Dietary / Q000008:administration & dosage*; D015430:Weight Gain
chemical_list: D012982:Sodium, Dietary