Fragile 3p14 in patients with von Hippel-Lindau syndrome compared to controls.
Lymphocytes from a series of ten patients with von Hippel-Lindau syndrome have been cultured under conditions designed to demonstrate the presence of fragile sites. Compared to a series of controls the subjects with von Hippel-Lindau syndrome show a small but significant increase in the level of FRA3B.
Webb
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Department of Clinical Genetics, Maternity Hospital, Birmingham, U.K.
Heath
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D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D008214:Lymphocytes; D008875:Middle Aged; D006623:von Hippel-Lindau Disease / Q000235:genetics*