[The efficacy of cyclophosphamide bolus therapy in a girl with SLE with a nephritic onset].
A case of glomerulonephritis as the initial clinical manifestation of SLE in a child is reported. Treatment with oral prednisone did not produce beneficial results either worth respect to the symptoms or the laboratory data. The association with intravenous Cyclophosphamide led to rapid improvement in clinical and serological patterns. Moreover this association has reduced the risk of end-stage renal failure with few serious complications, and no other side-effects.
Ballati
G
G
I Clinica Pediatrica, Università degli Studi di Roma La Sapienza.
Tucciarone
L
L
Diamanti
A
A
Frangella
E
E
Chiaramida
N
N
D001706:Biopsy; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000473:pathology; D008181:Lupus Nephritis / Q000188:drug therapy* / Q000473:pathology; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction
D003520:Cyclophosphamide; D011241:Prednisone
Efficacia della terapia con ciclofosfamide in boli in una bambina affetta da LES ad esordio nefritico.