title: [Local administration of metronidazole before hysterectomy--effect on infectious morbidity. A prospective study].
abstract: A prospective clinical trial was designed to examine the influence of a local application of metronidazole on postoperative infectious morbidity in 134 women undergoing vaginal and in 108 women undergoing abdominal hysterectomy. 116 patients received on the evening before hysterectomy a vaginal suppository of metronidazole (500 mg). The control group (126 patients) had no metronidazole prophylaxis. All patients, who underwent vaginal hysterectomy, were given additionally a single-shot prophylaxis with 1500 mg cefuroxim. With regard to febrile morbidity, urinary tract infection and abdominal wound or pelvic infection, there was a significant decrease in infectious morbidity. In women undergoing vaginal hysterectomy the infectious morbidity was reduced from 35.7% to 20.3% (p less than 0.05) in spite of systemic prophylaxis. In cases with abdominal hysterectomy, we saw a decrease from 64.3% to 26.9% (p less than 0.001). There was no effect on the incidence of urinary tract infections. Local prophylaxis with metronidazole in abdominal hysterectomy and additional to a systemic prophylaxis in vaginal hysterectomy reduces the infectious morbidity in our patients.
authors.affiliation: Städtische Frauenklinik Wiesbaden.
authors.forename: M
authors.initials: M
authors.lastname: Queck
authors.forename: E
authors.initials: E
authors.lastname: Weiss
authors.forename: P
authors.initials: P
authors.lastname: Berle
mesh_terms: D000282:Administration, Intravaginal; D002444:Cefuroxime / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007045:Hysterectomy, Vaginal; D007262:Infusions, Intravenous; D008795:Metronidazole / Q000008:administration & dosage*; D011292:Premedication; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D008795:Metronidazole; D002444:Cefuroxime
vernacular_title: Lokale Applikation von Metronidazol vor Hysterektomie--Einfluss auf infektiöse Morbidität. Eine prospektive Studie.