P29, an oestrogen receptor-associated protein, is down-regulated by mifepristone in first trimester human placenta and decidua.
P29 is an oestrogen receptor-associated protein which acts as a marker of oestrogen action in several systems. The concentration of P29 was measured in placenta and decidua from women following medical termination of pregnancy with the antiprogesterone steroid mifepristone (RU 38,486) and a prostaglandin E1 analogue, and compared with the concentration of P29 found in matched controls undergoing surgical aspiration of pregnancy. Oestrogen receptors were also measured in the same samples. Placental and decidual P29 concentrations (IU/mg protein) in patients treated with mifepristone were 9.6 (4.6-54) and 4.8 (1.3-13.3) (median and range), respectively. These values were significantly lower than the corresponding values, 39.5 (27-69) and 22.0 (2-107) in the surgical group. In contrast, the levels of oestrogen receptors did not change significantly in either decidua or placenta. These data show that mifepristone causes down-regulation of P29 in placenta and decidua, and therefore its action may disrupt oestrogen function in uterine tissues.
Rivera
J
J
Department of Obstetrics and Gynaecology, Facultad de Medicina, Universidad de Valencia, Spain.
Hill
N C
NC
López Bernal
A
A
Mackenzie
I Z
IZ
Cano
A
A
D000029:Abortion, Legal; D000293:Adolescent; D000328:Adult; D003656:Decidua / Q000187:drug effects* / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D006360:Heat-Shock Proteins; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D010750:Phosphoproteins / Q000187:drug effects* / Q000378:metabolism; D010920:Placenta / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011960:Receptors, Estrogen / Q000187:drug effects* / Q000378:metabolism
D006360:Heat-Shock Proteins; D010750:Phosphoproteins; D011960:Receptors, Estrogen; D015735:Mifepristone