Anticancer gelatin microspheres with multiple functions.
Biodegradable, hydrophilic gelatin microspheres (GM) with an average diameter of 70 microns were prepared by cross-linking gelatin with glutaraldehyde for hepatic intra-arterial infusion. An anticancer agent, mitomycin C (MMC), together with a radioisotope, 131I, were bound to the GM for chemotherapy and local internal radiotherapy. The 131I-labelled MMC-GM (131I-MMC-GM) could accumulate in the specific site and embolize the hepatic arteries after the hepatic intra-arterial infusion, while it caused various effects to the liver cells. The 131I-MMC-GM remained within the hepatic arteries for at least one month. In vitro release of drugs from the GM was also quantified using a dynamic dialysis method.
Yan
C H
CH
Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu, China.
Li
X W
XW
Chen
X L
XL
Wang
D Q
DQ
Zhong
D C
DC
Tan
T Z
TZ
Kitano
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials; D004285:Dogs; D016503:Drug Delivery Systems / Q000379:methods*; D005780:Gelatin; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D007457:Iodine Radioisotopes; D008863:Microspheres; D016685:Mitomycin / Q000008:administration & dosage / Q000493:pharmacokinetics
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D007457:Iodine Radioisotopes; D016685:Mitomycin; D005780:Gelatin