[The possibility of creating a vaccinal strain of Brucella abortus 19-BA with multiple antibiotic resistance].
The possibility of preparing B. abortus vaccine strain 19-BA with multiresistance to antibiotics was shown. The strain was obtained by the spontaneous induction of resistance to rifampicin with the subsequent transformation of nonconjugative hybrid plasmid pOVI which, in addition to rifampicin resistance, governed the resistance of brucellae to tetracycline, doxycycline, ampicillin, and streptomycin. Experiments on guinea pigs demonstrated the immunization with both multiresistant vaccine strain GSA1 and B. abortus initial vaccine strain 19-BA.
Gorelov
V N
VN
Gubina
E A
EA
Grekova
N A
NA
Skavronskaia
A G
AG
D000818:Animals; D002002:Brucella / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D002004:Brucella Vaccine / Q000235:genetics / Q000276:immunology*; D002003:Brucella abortus / Q000187:drug effects / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D002006:Brucellosis / Q000473:pathology / Q000517:prevention & control; D003227:Conjugation, Genetic / Q000187:drug effects / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization; D010957:Plasmids / Q000187:drug effects / Q000235:genetics; D011995:Recombination, Genetic / Q000187:drug effects / Q000235:genetics; D013997:Time Factors; D014774:Virulence / Q000187:drug effects / Q000235:genetics / Q000276:immunology
D002004:Brucella Vaccine
O vozmozhnosti sozdaniia vaktsinnogo shtamma Brucella abortus 19-BA s mnozhestvennoĭ ustoĭchivost'iu k antibiotikam.