Segregation analysis of autosomal fragile sites in three families with the fragile X chromosome.
Fragile sites on chromosomes 9, at 9p21, 10, at 10q25 and 12, at 12q24, were found in the lymphocytes of some members of three families during the study for detection of a fragile X chromosome. The sites were found to be heritable and folato-sensitive. The genetic implications of these results are discussed.
Barletta
C
C
OASI Institute for Research on Mental Retardation and Brain Aging, Enna, Italy.
Ragusa
R M
RM
Garofalo
G
G
Scillato
F
F
Ruggeri
M
M
D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002879:Chromosomes, Human, Pair 10; D002881:Chromosomes, Human, Pair 12; D002899:Chromosomes, Human, Pair 9; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree