(-)-Deprenyl can induce soluble superoxide dismutase in rat striata.
(-)-Deprenyl (0.25 or 2 mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate superoxide dismutase activity measured. (-)-Deprenyl at 2 mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (-)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed.
Clow
A
A
Division of Medical Science and Psychology, Polytechnic of Central London, United Kingdom.
Hussain
T
T
Glover
V
V
Sandler
M
M
Dexter
D T
DT
Walker
M
M
D000818:Animals; D003300:Copper / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology*; D003600:Cytosol / Q000187:drug effects / Q000201:enzymology; D004790:Enzyme Induction; D008297:Male; D008345:Manganese / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012642:Selegiline / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013482:Superoxide Dismutase / Q000096:biosynthesis*; D015032:Zinc / Q000378:metabolism
D012642:Selegiline; D008345:Manganese; D003300:Copper; D013482:Superoxide Dismutase; D015032:Zinc