Racial differences in the frequencies of scleroderma-related autoantibodies.
OBJECTIVE
To determine demographic differences in scleroderma-related autoantibodies.


METHODS
One hundred fifty-six patients with systemic sclerosis were prospectively examined for anticentromere antibodies (ACA), anti-topoisomerase I (anti-topo I, or Scl-70), antinucleolar, and anti-U1 RNP autoantibodies.


RESULTS
ACA was found in 36% of Caucasians and 4% of American blacks (P = 0.002, odds ratio [OR] 15). Anti-topo I was found in 37% of American blacks, compared with 17% of Caucasians (P = 0.04, OR 3). No significant differences in the frequencies of antinucleolar and anti-U1 RNP autoantibodies were found.


CONCLUSIONS
These data suggest important demographic differences in scleroderma-associated autoantibodies.
Reveille
J D
JD
Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center, Houston.
Durban
E
E
Goldstein
R
R
Moreda
R
R
Arnett
F C
FC
D001323:Autoantibodies / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D006630:Hispanic or Latino; D006801:Humans; D009687:Nuclear Proteins / Q000276:immunology; D011446:Prospective Studies; D012595:Scleroderma, Systemic / Q000208:ethnology* / Q000276:immunology*; D044465:White People / Q000235:genetics*
D001323:Autoantibodies; D009687:Nuclear Proteins