Effect of stabilization temperature on the degradation of adriamycin in albumin microspheres.
The effect of stabilization temperature on the degradation of adriamycin HCl during the preparation of albumin microspheres was investigated. The degradation of adriamycin HCl by heating at various temperature with different time interval in dried adriamycin HCl powder, adriamycin HCl aqueous solution, wetted Adriablastina (adriamycin HCl with lactose) powder and Adriablastina aqueous solution was also studied. In the presence of water the degradation of adriamycin HCl was found; whereas, in the absence of water no degradation occurred. The degradation of adriamycin HCl in solution and wetted powder showed a zero order reaction. An increase in temperature increased degradation rate. The rate constant for adriamycin HCl degradation in Adriablastina solution obtained was in good agreement with that in adriamycin HCl solution. It was suggested that the presence of lactose had no interference in the degradation of adriamycin HCl. The zero-order reaction of degradation was attributed to the drug behaved like a suspension. The degradation of adriamycin HCl at various stabilization temperature during the preparation of microspheres had the same tendency as those of the adriamycin HCl solution and the wetted adriamycin HCl powder that were heated by the DSC instrument with the condition similar to the preparation of microspheres.
Law
S L
SL
Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Chiang
C H
CH
Lin
F M
FM
Teh
G W
GW
D004317:Doxorubicin; D004355:Drug Stability; D006358:Hot Temperature; D008863:Microspheres; D012710:Serum Albumin, Bovine
D012710:Serum Albumin, Bovine; D004317:Doxorubicin