A prospective, randomized trial comparing two different intrauterine insemination regimens in controlled ovarian hyperstimulation cycles.
OBJECTIVE
To compare a single periovulatory intrauterine insemination (IUI) with a regimen employing two IUIs, one before ovulation and one after ovulation, in patients undergoing controlled ovarian hyperstimulation with human menopausal gonadotropins (hMG) combined with human chorionic gonadotropin (hCG).


METHODS
A randomized, prospective trial.


METHODS
Thirty-one consecutive patients undergoing 49 cycles of controlled ovarian hyperstimulation/IUI were studied in a tertiary care setting.


METHODS
Ovulation was determined sonographically. The establishment of a clinical pregnancy was defined by either ultrasonographic verification of cardiac activity within an intrauterine fetus, or histologic confirmation of trophoblast in a surgical specimen.


RESULTS
Clinical pregnancies developed in 2 of 23 cycles in the single insemination group, compared with 12 of the 23 cycles in the double insemination group. Cycle fecundity was significantly higher for group II (0.522) than for group I (0.087) patients (P = 0.003).


CONCLUSIONS
In hMG/hCG cycles, two IUIs timed as described above are superior to one periovulatory insemination.
Silverberg
K M
KM
Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio 78284-7836.
Johnson
J V
JV
Olive
D L
DL
Burns
W N
WN
Schenken
R S
RS
D015925:Cryopreservation; D005260:Female; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D010053:Ovary / Q000503:physiopathology*; D010060:Ovulation; D011247:Pregnancy; D011446:Prospective Studies; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa
D008596:Menotropins