[Brain monoamine oxidase during aging].
MAO activities were studied in 4 months old and 19 months old Wistar rats. MAO-B activity was higher in brain stem and hemispheres of old rats as compared with that of young animals. MAO-A activity was lowered only in the stem and was not changed in the hemispheres of old rats. Actinomycin D increased MAO-A activity in the brain stem of young rats and lowered MAO-B activity in the hemispheres of old rats. Emotional stress increased MAO-A activity in the stem and hemispheres of both young and old animals. Actinomycin D abolished the stress effect on these two forms of MAO both young and old rats. Delta-sleep including peptide at the dose of 120 micrograms/100 g increased MAO-A activity and lowered MAO-B activity in young animals but did not affect the MAO-A activity in old rats.
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D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D003609:Dactinomycin / Q000494:pharmacology; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000201:enzymology
D007527:Isoenzymes; D003609:Dactinomycin; D003701:Delta Sleep-Inducing Peptide; D008995:Monoamine Oxidase
Monoaminoksidazy mozga pri starenii.