title: Biochemical abnormalities in developing E1 mouse.
abstract: Complex biochemical abnormalities were found in the early developmental stage of the E1 mouse. First, the E1 mouse has abnormal levels of specific amino acid concentration within a week from birth. Second, an unusual expression of poly(A)+ RNA from the one-day newborn liver of the E1 mouse was detected by use of Cot 100 DNA as a probe. Third, sodium channels are increased in synaptosomes and at the mRNA expression level of the 3 or 4-week-old E1 mouse brains, compared with the ddY mouse. These results suggest that the biochemical abnormalities described in this study may affect greatly the epileptogenesis of E1 mouse.
authors.affiliation: Department of Molecular Biology, University of Occupational Environmental Health School of Medicine, Kitakyushu, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sashihara
authors.forename: I
authors.initials: I
authors.lastname: Aramaki
authors.forename: Y
authors.initials: Y
authors.lastname: Murai
authors.forename: T
authors.initials: T
authors.lastname: Mita
mesh_terms: D000367:Age Factors; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000503:physiopathology; D015342:DNA Probes; D017029:Epilepsy, Complex Partial / Q000235:genetics / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology; D051379:Mice; D008818:Mice, Neurologic Mutants; D012640:Seizures / Q000235:genetics / Q000503:physiopathology*
chemical_list: D000596:Amino Acids; D015342:DNA Probes