title: The use of a single pulse of intravenous methylprednisolone in the treatment of corneal graft rejection. A preliminary report.
abstract: In corneal graft rejection, rapid reversal of the rejection process is necessary to minimise endothelial cell loss. Ten consecutive patients with acute endothelial rejection were treated with a single 500 mg pulse of methylprednisolone intravenously and topical prednisolone 1% drops hourly. The rejection episode was successfully reversed in eight (80%) of the 10 grafts. This preliminary trial indicates that cortico-steroid pulse therapy may be beneficial in the management of severe corneal graft rejection with the advantage of avoiding prolonged oral corticosteroid therapy.
authors.affiliation: Department of Ophthalmology, Groote Schuur Hospital, Cape Town, South Africa.
authors.forename: J C
authors.initials: JC
authors.lastname: Hill
authors.forename: R
authors.initials: R
authors.lastname: Maske
authors.forename: P G
authors.initials: PG
authors.lastname: Watson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016039:Corneal Transplantation; D004359:Drug Therapy, Combination; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D011239:Prednisolone; D008775:Methylprednisolone