Plasmapheresis in conjunction with the dextran sulfate cellulose column for hypertriglyceridemic patient: a comparison with familial hypercholesterolemia.
For assessment of the usefulness of a dextran sulfate cellulose (DSC) column in the conduct of plasmapheresis (DSC lipoprotein adsorption, DSC-LA) for patients with hypertriglyceridemia on hemodialysis, a study was conducted to determine whether the adsorption of lipoproteins on a column varies in response to a variation in the lipoprotein composition. A patient with type V hyperlipoproteinemia on hemodialysis, a patient with type IIa homozygous, and a patient with type IIa heterozygous familial hypercholesterolemia were used in this study. In all patients, apolipoprotein B- and E-containing lipoproteins were removed preferentially by a DSC column. Following DSC-LA, abdominal pain before DSC-LA in a patient with type V hyperlipoproteinemia subsided, and regression of tuberous and tendinous xanthomas was induced in familial hypercholesterolemia. In cases of hyperlipoproteinemia, this column thus appears to exert a therapeutic effect regardless of the type of disease.
Ito
H
H
First Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Okada
H
H
Kakuta
S
S
Fujisawa
K
K
Nagase
M
M
Naito
C
C
D000125:Achilles Tendon; D000327:Adsorption; D000328:Adult; D002853:Chromatography, Liquid; D016264:Dextran Sulfate; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000628:therapy*; D015228:Hypertriglyceridemia / Q000097:blood / Q000628:therapy*; D008074:Lipoproteins / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000628:therapy; D010956:Plasmapheresis / Q000379:methods*; D014973:Xanthomatosis / Q000628:therapy
D008074:Lipoproteins; D016264:Dextran Sulfate