Characteristics of vascular responses to endothelin-1 of simian digital arteries that distribute their branches to the skin.
Using the cannula-inserting method, vascular responses to endothelin-1 were investigated in the isolated and perfused simian digital artery. Endothelin-1 produced a strong and sustained vasoconstriction with EC50 of 5.15 +/- 1.24 ng. The endothelin-1-induced vasoconstriction was significantly inhibited in the Ca(++)-removed perfusate. It was partly attenuated by diltiazem, a potent Ca++ entry blocker, but not affected by alpha-adrenoceptor antagonist phentolamine, indicating that endothelin-1 causes vasoconstriction by either the extracellular Ca++ entry or intracellular movement of Ca++ from the cytosolic storage site. From these results, it is suspected that ET-1 is partially related to skin circulatory disturbances such as Raynaud's phenomenon.
Haniuda
K
K
Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
Ito
T
T
Chiba
S
S
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016232:Endothelins / Q000494:pharmacology*; D005260:Female; D005385:Fingers / Q000098:blood supply*; D008251:Macaca / Q000033:anatomy & histology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D012867:Skin / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects
D016232:Endothelins; D011189:Potassium Chloride; D004110:Diltiazem; D002118:Calcium; D009638:Norepinephrine