Germinal centres in T-cell-dependent antibody responses.
For more than a century follicles have been recognized as a site of intense cell proliferation and cell death. At last the significance of this activity is beginning to emerge: antigen-driven B-cell proliferation, somatic mutation, positive and negative selection, and memory and plasma cell development all appear to take place within the follicle.
Liu
Y J
YJ
Dept of Immunology, University of Birmingham Medical School, UK.
Johnson
G D
GD
Gordon
J
J
MacLennan
I C
IC
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D009154:Mutation; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000276:immunology*