Optimization of doxorubicine incorporation and of the yield of polybutylcyanacrylate nanoparticles.
The preparation from w/o microemulsion of polybutylcianacrylate nanocapsules incorporating doxorubicine was optimized applying a multivariate experimental design. Different variables were investigated; the responses were polymer yield, concentration of the drug in the particles and percentage of the drug incorporated. A preliminary study was carried out with the strategy of fractional factorial design; the following step was a central composite design in order to study the most important causal variables. The information collected were treated by the response surface method (REGFAC package). The optimization allowed to maximize the responses; an incorporation of about 10% of doxorubicine and a yield of about 95% were obtained, starting from values notably lower of both incorporation and yield.
Carpignano
R
R
Istituto di Chimica Organica Industriale, Università di Torino, Italy.
Gasco
M R
MR
Morel
S
S
D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004659:Enbucrilate / Q000737:chemistry; D008863:Microspheres
D004317:Doxorubicin; D004659:Enbucrilate