The biochemical specific-locus test and a new multiple-endpoint mutation detection system: considerations for genetic risk assessment.
The importance of studying the generation of mutations in mouse germ cells is emphasized, and the utility of the biochemical specific-locus test in detecting germinal mutations is described. All experiments performed to date using this test are listed. The relevance of dominant mutations to human genetic risk is also discussed. Finally, the value of using multiple tests for the study of in vivo germinal mutations is discussed, and the design for a new multiple-endpoint system is presented.
Lewis
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Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709-2194.
D000818:Animals; D005799:Genes, Dominant; D005854:Germ Cells / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests / Q000592:standards*; D009153:Mutagens / Q000633:toxicity; D012306:Risk; D013091:Spermatogenesis / Q000187:drug effects
D009153:Mutagens