Centella Asiatica Triterpenic Fraction (CATTF) reduces the number of circulating endothelial cells in subjects with post phlebitic syndrome.
Here we report a study performed in order to assess the number of circulating endothelial cells (EC) in normal subjects and in patients with postphlebitic syndrome (PPS), and the effect of treatment with Centella Asiatica Triterpenic Fraction (CATTF), a drug which has been demonstrated to be effective in promoting wound healing in vivo. EC counts were determined by means of differential centrifugation and phase contrast microscopy. Patients with PPS showed an increased number of circulating EC in comparison to normal subjects (3.8 +/- 1.2 cells versus 1.5 +/- 0.6 per counting chamber). Treatment for three weeks with CATTF caused a statistically significant reduction of circulating EC (1.80 +/- 0.6 cells per counting chamber).
Montecchio
G P
GP
Clinica Medica II, IRCCS Policlinico San Matteo, Pavia, Italy.
Samaden
A
A
Carbone
S
S
Vigotti
M
M
Siragusa
S
S
Piovella
F
F
D002452:Cell Count; D004341:Drug Evaluation; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D011186:Postphlebitic Syndrome / Q000097:blood / Q000188:drug therapy*; D014315:Triterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D014689:Venous Insufficiency / Q000097:blood / Q000188:drug therapy
C005084:TECA; D014315:Triterpenes