title: [Clinical study on ivermectin against Strongyloides stercoralis].
abstract: We previously reported the efficacy of ivermectin (IVM) for the treatment of 23 strongyloidiasis patients. We now reported the efficacy and safety of IVM therapy on 54 patients. Fifty-four patients, 28 males and 26 females, received a single oral dose of IVM one hour before breakfast and this treatment was repeated 2 weeks later. The following results were obtained: 1) The cure rate at 2 weeks after the initial treatment was 92.5% (49 of 53 patients) and 2 weeks after the second course was 96.0% (48 of 50 patients). 2) Four patients (7.4%) complained of diarrhea (n = 2 patients), constipation (n = 1), borborygmus (n = 1), dizziness (n = 1), diplopia (n = 1) and peri-anal itching (n = 1) after the first treatment. Three patients (5.6%) complained of borborygmus (n = 1), itching (n = 1) and exanthema (n = 1) after the second treatment. But all symptoms were mild and required no treatment and subsided in a few days. 3) Positive rate of HTLV-1 antibody was 25.9% in the patients. As described above, although side effects occurred in some cases, they were mild and transient. From these results, we concluded that IVM is an effective drug for strongyloidiasis.
authors.affiliation: First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus.
authors.forename: K
authors.initials: K
authors.lastname: Shikiya
authors.forename: T
authors.initials: T
authors.lastname: Uehara
authors.forename: H
authors.initials: H
authors.lastname: Uechi
authors.forename: J
authors.initials: J
authors.lastname: Ohshiro
authors.forename: T
authors.initials: T
authors.lastname: Arakaki
authors.forename: T
authors.initials: T
authors.lastname: Oyakawa
authors.forename: H
authors.initials: H
authors.lastname: Sakugawa
authors.forename: F
authors.initials: F
authors.lastname: Kinjo
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: R
authors.initials: R
authors.lastname: Asato
mesh_terms: D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007559:Ivermectin / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013322:Strongyloidiasis / Q000188:drug therapy*
chemical_list: D007559:Ivermectin