Nitrendipine is a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes.
Nitrendipine, a classical blocker of L-type Ca2+ channels, is shown to be a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na+ and K+ concentrations and in which the channel was activated using the Ca2+ ionophore ionomycin, nitrendipine inhibited K+(86Rb+) influx with an I50 of around 130 nM. Similar results were obtained for K+(86Rb+) efflux, and for K+(86Rb+) influx into cells suspended in a high-K+ medium.
Ellory
J C
JC
University Laboratory of Physiology, University of Oxford, UK.
Kirk
K
K
Culliford
S J
SJ
Nash
G B
GB
Stuart
J
J
D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D009568:Nitrendipine / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*
D015221:Potassium Channels; D009568:Nitrendipine; D002118:Calcium