[Prevention of post-resuscitation metabolic disorders by the antioxidant oxypyridine-6].
Acute mortal hemorrhage in rats induced excessive activation of lipid peroxidation, while accumulated high amounts of lipid hydroperoxides impaired energy metabolism in brain and heart tissues. Preadministered antioxidant hydroxypyridine-6, which increased the lipids antioxidation activity and reduced inhibition of the antioxidative enzymes, limited distinctly the lipid peroxidation rate in brain, heart, lung and liver tissues and contributed to maintaining energy metabolism. The drug diminished 2-fold the early postresuscitation lethality.
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D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D016063:Blood Loss, Surgical; D001921:Brain / Q000378:metabolism; D004734:Energy Metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008291:Malate Dehydrogenase / Q000097:blood; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D012151:Resuscitation; D012260:Ribonucleases / Q000097:blood
D011725:Pyridines; C014047:hydroxypyridines; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D001219:Aspartate Aminotransferases; D012260:Ribonucleases
Preduprezhdenie postreanimationnykh metabolicheskikh naruxheniĭ antioksidantom oksipiridinom-6.