title: Hydrogen bonds involving sulfur atoms in proteins.
abstract: Intrachain hydrogen bonds are a hallmark of globular proteins. Traditionally, these involve oxygen and nitrogen atoms. The electronic structure of sulfur is compatible with hydrogen bond formation as well. We surveyed a set of 85 high-resolution protein structures in order to evaluate the prevalence and geometry of sulfur-containing hydrogen bonds. This information should be of interest to experimentalists and theoreticians interested in protein structure and protein engineering.
authors.affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446.
authors.forename: L M
authors.initials: LM
authors.lastname: Gregoret
authors.forename: S D
authors.initials: SD
authors.lastname: Rader
authors.forename: R J
authors.initials: RJ
authors.lastname: Fletterick
authors.forename: F E
authors.initials: FE
authors.lastname: Cohen
mesh_terms: D000818:Animals; D003545:Cysteine / Q000737:chemistry; D006860:Hydrogen Bonding; D008715:Methionine / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D011506:Proteins; D013455:Sulfur; D008715:Methionine; D003545:Cysteine