Morphometry of the corpus callosum in normal aging and Alzheimer's disease.
Changes of the human corpus callosum in normal aging and Alzheimer's disease were analysed by means of morphometry. A standardized computerized evaluation program was implemented allowing objective, quantitative and reproducible data. The various parts of the corpus callosum showed a different pattern of changes in normal aging as compared to Alzheimer's disease. In conclusion, in normal aging affects mostly the front-temporal interhemispheric fiber systems, whereas in Alzheimer's disease the parietotemporal commissural fibers are altered.
Weis
S
S
Institute of Anatomy, Medical University Lübeck, Federal Republic of Germany.
Jellinger
K
K
Wenger
E
E
D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology*; D003337:Corpus Callosum / Q000033:anatomy & histology / Q000473:pathology*; D006801:Humans; D012016:Reference Values