title: Interaction between thiopentone and subhypnotic doses of ketamine.
abstract: The hypnotic effects of thiopentone and ketamine were studied in ASA Grade I female patients aged 20-30 without premedication. The dose-response curves of ketamine 0.4 mg kg-1 and thiopentone following ketamine 0.4 mg kg-1 were determined by probit analysis. The interaction between ketamine and thiopentone was found to be an antagonistic one. This effect can be interpreted as a consequence of the different neurophysiological spectra of action of the two drugs.
authors.affiliation: Institute of Anesthesiology and Intensive Care, University of Padua, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Manani
authors.forename: S
authors.initials: S
authors.lastname: Valenti
authors.forename: E
authors.initials: E
authors.lastname: Vincenti
authors.forename: A
authors.initials: A
authors.lastname: Segatto
authors.forename: G
authors.initials: G
authors.lastname: Zanette
authors.forename: G P
authors.initials: GP
authors.lastname: Giron
authors.forename: L
authors.initials: L
authors.lastname: Galzigna
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage*; D013514:Surgical Procedures, Operative; D013874:Thiopental / Q000008:administration & dosage*
chemical_list: D007649:Ketamine; D013874:Thiopental