title: Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB.
abstract: In vertebrates, the formation and maintenance of neuronal connections are subject to regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the identification and characterization of a novel neurotrophic factor designated neurotrophin-5 (NT-5). NT-5 is structurally related to nerve growth factor and is expressed in embryonic as well as adult tissues. Recombinant NT-5 promotes the survival of peripheral sensory and sympathetic neurons and induces differentiation of the pheochromocytoma cell line PC12. NT-5 activates two trk-related tyrosine kinase receptors and shares these receptors with other neurotrophins. Activation of multiple receptors may permit a single neurotrophin to control target innervation by distinct neuronal populations. Receptor sharing could enable neurotrophic factors emanating from distinct targets to cooperate in regulating neurons with multiple connections.
authors.affiliation: Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080.
authors.forename: L R
authors.initials: LR
authors.lastname: Berkemeier
authors.forename: J W
authors.initials: JW
authors.lastname: Winslow
authors.forename: D R
authors.initials: DR
authors.lastname: Kaplan
authors.forename: K
authors.initials: K
authors.lastname: Nikolics
authors.forename: D V
authors.initials: DV
authors.lastname: Goeddel
authors.forename: A
authors.initials: A
authors.lastname: Rosenthal
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000302:isolation & purification; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D051381:Rats / Q000235:genetics; D020801:Receptor, Ciliary Neurotrophic Factor; D020917:Receptor, trkA; D011994:Recombinant Proteins
chemical_list: D008565:Membrane Proteins; D009414:Nerve Growth Factors; D011518:Proto-Oncogene Proteins; D020801:Receptor, Ciliary Neurotrophic Factor; D011994:Recombinant Proteins; C071951:neurotrophin 5; D004247:DNA; D011505:Protein-Tyrosine Kinases; D020917:Receptor, trkA