Evaluation of a method for simultaneous quantification of codeine, ethylmorphine and morphine in blood.
Codeine, ethylmorphine and morphine are the most commonly detected opiates in forensic blood samples in Norway. A method for the simultaneous quantification of these opiates utilizing solid phase extraction and gas chromatography-mass spectrometry has been evaluated. The detection limits were 0.026 mumol/l for codeine, 0.025 mumol/l for ethylmorphine and 0.032 mumol/l for morphine (corresponding to 7.8, 7.8 and 9.1 micrograms/l, respectively). The analytical variations at concentrations of 1.0 mumol/l codeine, 1.0 mumol/l ethylmorphine and 0.5 mumol/l morphine were less than 5%.
Gjerde
H
H
National Institute of Forensic Toxicology, Oslo, Norway.
Fongen
U
U
Gundersen
H
H
Christophersen
A S
AS
D003061:Codeine / Q000097:blood*; D005036:Ethylmorphine / Q000097:blood*; D005069:Evaluation Studies as Topic; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009020:Morphine / Q000097:blood*; D011237:Predictive Value of Tests
D009020:Morphine; D005036:Ethylmorphine; D003061:Codeine