Effects of naloxone and naltrexone on receptive and proceptive behaviors in female rats.
The sexual receptive and proceptive behaviors induced by opiate antagonists, naloxone and naltrexone in estrogen-primed ovariectomized rats were observed under the presence of sexually active males. The females were treated intraperitoneally with naloxone or naltrexone at doses ranging from 0.5 to 4.0 mg/kg and the sexual behavior of females was tested before and after the injection of drug. The results obtained suggest that the opiate antagonists play a role in the regulation of lordosis behavior, but not proceptive behavior in female rats.
Saito
T R
TR
Department of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Aoki
S
S
Hokao
R
R
Amao
H
H
Wakafuji
Y
Y
Sugiyama
M
M
Takahashi
K W
KW
D000818:Animals; D005260:Female; D009270:Naloxone / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013268:Stimulation, Chemical
D009270:Naloxone; D009271:Naltrexone