title: [Clinicopathological features of metastatic pulmonary calcinosis with malignant neoplasm].
abstract: Metastatic pulmonary calcinosis is a rare complication seen in malignancies accompanied by hypercalcemia, or chronic renal failure. We reviewed the clinicopathological findings of 8 cases of metastatic pulmonary calcinosis accompanied malignancy revealed at autopsy. The underlying diseases were malignant lymphoma in 3 cases (adult T cell lymphoma in 2 cases), multiple myeloma in 2, lung cancer in 2, and acute myelocytic leukemia in 1, all cases were complicated by hypercalcemia and renal failure. Chest X-ray revealed almost normal findings in 2 cases, bilateral diffuse infiltrates in 4, bilateral infiltrates in the apex in 1, and right atelectasis in 1. Bone scintigraphy was performed in 4 cases, and revealed warm pulmonary uptake in 1 patient with multiple myeloma and 1 with lung cancer, but normal findings in the 2 other cases. Histopathological examination revealed diffuse alveolar septal edema and fibrosis due to calcium deposition, which were considered to be the cause of respiratory failure. Metastatic pulmonary calcinosis is a rare but a serious complication in malignancies accompanied by hypercalcemia and renal failure, and bone scintigraphy seems to be a useful method for its diagnosis.
authors.affiliation: Department of Respiratory Medicine, Tenri Hospital, Nara, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nambu
authors.forename: T
authors.initials: T
authors.lastname: Iwata
authors.forename: K
authors.initials: K
authors.lastname: Oida
authors.forename: Y
authors.initials: Y
authors.lastname: Kohri
authors.forename: Y
authors.initials: Y
authors.lastname: Taguchi
authors.forename: K
authors.initials: K
authors.lastname: Tomii
authors.forename: M
authors.initials: M
authors.lastname: Mino
authors.forename: Y
authors.initials: Y
authors.lastname: Yunoki
authors.forename: K
authors.initials: K
authors.lastname: Ichijima
authors.forename: Y
authors.initials: Y
authors.lastname: Kobashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000473:pathology*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D007674:Kidney Diseases / Q000150:complications; D007938:Leukemia / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology