title: Exclusion map of Salla disease: attempts to localize the disease gene using a computer program.
abstract: Salla disease is a lysosomal storage disorder due to impaired transport of free sialic acid across the lysosomal membrane. The clinical presentation of this autosomal recessive trait is severe psychomotor retardation from early infancy on. In order to determine the gene locus for the disease we have initiated a genetic linkage study using polymorphic gene markers in representative family material comprising about 60% of all families known to be affected with Salla disease. Here we present an exclusion map based on combined linkage data from 64 informative loci on 19 autosomes. Theoretically, at least 55% of the genome has been excluded as a locus for the disease gene, while some chromosome areas, particularly the long arm of chromosome 2, are highlighted as possible sites for the gene locus.
authors.affiliation: Department of Medical Genetics, University of Turku, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Haataja
authors.forename: J
authors.initials: J
authors.lastname: Schleutker
authors.forename: M
authors.initials: M
authors.lastname: Renlund
authors.forename: A
authors.initials: A
authors.lastname: Palotie
authors.forename: L
authors.initials: L
authors.lastname: Peltonen
authors.forename: P
authors.initials: P
authors.lastname: Aula
mesh_terms: D002874:Chromosome Mapping; D008040:Genetic Linkage; D006801:Humans; D016464:Lysosomal Storage Diseases / Q000235:genetics*; D011110:Polymorphism, Genetic; D012984:Software