title: Miniature membrane oxygenator for use in neonatal ECMO.
abstract: A new miniature membrane oxygenator (Kuraray KMO, size, 0.3 m2, with a priming volume of 47 ml, compliance of less than 0.1 ml/100 mmHg, and pressure loss of 45 mmHg) with improved gas transfer and mechanical durability was developed and tested. The membrane material is a hollow fiber double layer polyolefin. The testing procedures determined by the AAMI were followed, and the results showed improved O2 and CO2 transfer (70 ml/min and 55 ml/min, respectively). Hemolysis was within acceptable limits, and plasma leakage was undetectable after 7 days of perfusion. Clinical study demonstrated satisfactory performance.
authors.affiliation: Pathophysiology Research Laboratory, National Children's Medical Center, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Katayama
authors.forename: K
authors.initials: K
authors.lastname: Miyasaka
authors.forename: I
authors.initials: I
authors.lastname: Hirose
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: R
authors.initials: R
authors.lastname: Mimura
authors.forename: H
authors.initials: H
authors.lastname: Akasu
mesh_terms: D002245:Carbon Dioxide / Q000097:blood; D004867:Equipment Design; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D006461:Hemolysis / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008904:Miniaturization / Q000295:instrumentation*; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen