title: Diffuse brain swelling in severely head-injured children. A report from the NIH Traumatic Coma Data Bank.
abstract: In this study, data were prospectively collected from 753 patients (111 children and 642 adults) with severe head injury and examined for evidence of diffuse brain swelling and its association with outcome. Diffuse brain swelling occurred approximately twice as often in children (aged 16 years or younger) as in adults. A high mortality rate (53%) was found in these children, which was three times that of the children without diffuse brain swelling (16%). Adults with diffuse brain swelling had a mortality rate (46%) similar to that of children, but only slightly higher than that for adults without diffuse brain swelling (39%). When the diagnosis of diffuse brain swelling was expanded to include patients with diffuse brain swelling plus small parenchymal hemorrhages (less than 15 cu cm), these mortality rates were virtually unchanged.
authors.affiliation: Division of Neurosurgery, University of Texas Medical Branch, Galveston.
authors.forename: E F
authors.initials: EF
authors.lastname: Aldrich
authors.forename: H M
authors.initials: HM
authors.lastname: Eisenberg
authors.forename: C
authors.initials: C
authors.lastname: Saydjari
authors.forename: T G
authors.initials: TG
authors.lastname: Luerssen
authors.forename: M A
authors.initials: MA
authors.lastname: Foulkes
authors.forename: J A
authors.initials: JA
authors.lastname: Jane
authors.forename: L F
authors.initials: LF
authors.lastname: Marshall
authors.forename: A
authors.initials: A
authors.lastname: Marmarou
authors.forename: H F
authors.initials: HF
authors.lastname: Young
mesh_terms: D000293:Adolescent; D000328:Adult; D001929:Brain Edema / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D016009:Chi-Square Distribution; D002648:Child; D006259:Craniocerebral Trauma / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D016208:Databases, Factual; D015600:Glasgow Coma Scale; D006801:Humans; D007022:Hypotension / Q000209:etiology; D000860:Hypoxia / Q000209:etiology; D007427:Intracranial Pressure; D015993:Life Tables; D011446:Prospective Studies; D016019:Survival Analysis