title: Beta glucuronidase and hyperbilirubinaemia in breast fed infants of diabetic mothers.
abstract: A prospective study was performed comparing bilirubin concentrations in 10 breast fed term infants of diabetic mothers (IDM) to those of 10 breast fed normal term infants. The beta-glucuronidase concentrations in serum and breast milk were assayed in the respective mothers. Significantly higher bilirubin concentrations were noted in the IDM group. Serum and breast milk beta-glucuronidase concentrations were significantly higher in diabetic mothers as compared with those of non-diabetic mothers. We suggest that the high concentration of beta-glucuronidase in breast milk of diabetic mothers is an additional important cause leading to hyperbilirubinaemia in their breast fed infants.
authors.affiliation: Neonatology Unit, Hasharon Hospital, Golda Medical Centre, Petah-Tiqva, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Sirota
authors.forename: M
authors.initials: M
authors.lastname: Ferrera
authors.forename: N
authors.initials: N
authors.lastname: Lerer
authors.forename: F
authors.initials: F
authors.lastname: Dulitzky
mesh_terms: D001663:Bilirubin / Q000097:blood*; D001942:Breast Feeding; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D007223:Infant; D008895:Milk, Human / Q000201:enzymology*; D011446:Prospective Studies
chemical_list: D005966:Glucuronidase; D001663:Bilirubin