[The search for new antiparasitic agents. 8. The synthesis and study of the acute toxicity, anti-alveolar hydatid and antihymenolepiasis activity of 1-alkyl-4[4-(heterylamino)phenyl]piperazines].
The synthesis and the acute toxicity and anticestodal activity of l-alkyl-4-[-(heterylamino)phenyl]-piperazines are presented. These compounds were found to be able to suppress the growth of larvocysts of Echinococcus multilocularis in cotton rats when injected intraperitoneally in a single dose of 0.25 g/kg, close to capacity of mebendazole. The tested compounds were also highly effective against the adult stage of Hymenolepis nana. Experimentally infected mice given an oral single dose of 0.2-0.5 g/kg of the drug were radically cured.
Mikhaĭlitsyn
F S
FS
Kozyreva
N P
NP
Lebedeva
M N
MN
Kovalenko
F P
FP
Dzhabarova
V I
VI
Lychko
N D
ND
Baiandina
D G
DG
Naĭdenova
A S
AS
D000818:Animals; D000923:Anticestodal Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004443:Echinococcosis / Q000188:drug therapy*; D005260:Female; D006925:Hymenolepiasis / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010879:Piperazines / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D016205:Sigmodontinae
D000923:Anticestodal Agents; D010879:Piperazines
Izyskanie novykh protivoparazitarnykh sredstv. 8. Sintez i issledovanie ostroĭ toksichnosti, protivoal'veokokkoznoĭ i protivogimenolepidoznoĭ aktivnosti nekotorykh 1-alkil-4[4-(geterilamino)fenil]piperazinov.