[Parameters for the formulation of physical-technical characteristics of granules of theophylline obtained by extrusion-spheronization].
Spheroids are prepared from microcrystalline cellulose in binary and compound combination with lactose and theophylline, in certain fixed conditions of extrusion and of spheronisation. The present work envisages the influence of combinated raw materials upon the physical-technique characteristic of the made spheroids. Besides a variation in the granulometric distribution a statical study through analysis of variance brings to the fore that the parameters of formulation contribute to modify the properties of hardness and of friability of the minigranules.
Bataille
B
B
Laboratoire de Pharmacie Galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie Université de Montpellier 1.
Rahman
L
L
Jacob
M
M
D004339:Drug Compounding; D010316:Particle Size; D011208:Powders; D013806:Theophylline
D011208:Powders; D013806:Theophylline
Etude des paramètres de formulation sur les caractéristiques physicotechniques de granules de théophylline obtenus par extrusion-sphéronisation.