[Role of mast cells in reactions of the blood system in inflammation].
On the model of the acute infectious peritonitis in mice it is shown that the previously osmotic disruption of the peritoneal mast cell population remarkably affects the inflammatory focus, blood and bone-marrow leukocytic reactions. The initial neutrophil accumulation increase and the earlier and more intensive leukocytosis and activation of granulo-monocytopoiesis are established. At the same time the kinetics of monocytes in inflammatory focus is expressed weaker and testifies to the prolongation of the inflammatory response. Thus, in the natural inflammatory conditions mast cells of the inflammatory focus directly or indirectly modulate leukocytes and hematopoiesis.
Klimenko
N A
NA
Dygaĭ
A M
AM
Abramova
E V
EV
Simanina
E V
EV
Gumilevskiĭ
B Iu
BIu
Boldyshev
D A
DA
Gol'dberg
E D
ED
D000208:Acute Disease; D000818:Animals; D001854:Bone Marrow Cells; D006410:Hematopoiesis; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D007962:Leukocytes / Q000502:physiology; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000502:physiology; D010538:Peritonitis / Q000503:physiopathology
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