title: Germinal centres in T-cell-dependent antibody responses.
abstract: For more than a century follicles have been recognized as a site of intense cell proliferation and cell death. At last the significance of this activity is beginning to emerge: antigen-driven B-cell proliferation, somatic mutation, positive and negative selection, and memory and plasma cell development all appear to take place within the follicle.
authors.affiliation: Dept of Immunology, University of Birmingham Medical School, UK.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Liu
authors.forename: G D
authors.initials: GD
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: Gordon
authors.forename: I C
authors.initials: IC
authors.lastname: MacLennan
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008221:Lymphoid Tissue / Q000166:cytology / Q000276:immunology; D009154:Mutation; D012641:Selection, Genetic; D013601:T-Lymphocytes / Q000276:immunology*