title: New pharmacokinetic methods for the study of antiepileptic medications of the 1990s.
abstract: New methods that will be useful in the study of the pharmacokinetics of both new and established antiepileptic drugs include stable-isotope tracer techniques for studies of absorption, elimination, and drug interactions; the microperfusion technique and the staggered stable-isotope administration technique for the study of distribution; and the correction of trough drug serum concentration values to mean serum concentration values. New pharmacokinetic methods for a study of drugs with new and unique properties include a double stable-isotope technique to deal with the unique pharmacokinetic properties of prodrugs and techniques for describing the biologic half-life of drugs that have a high affinity for active sites.
authors.affiliation: Department of Neurology, Boston University School of Medicine, MA 02118.
authors.forename: T R
authors.initials: TR
authors.lastname: Browne
authors.forename: G K
authors.initials: GK
authors.lastname: Szabo
mesh_terms: D000042:Absorption; D000927:Anticonvulsants / Q000378:metabolism / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001923:Brain Chemistry; D003956:Dialysis; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007553:Isotope Labeling; D010477:Perfusion; D010599:Pharmacokinetics
chemical_list: D000927:Anticonvulsants