title: Role of interleukin-5 in local accumulation of eosinophils in mouse allergic peritonitis.
abstract: The injection of ragweed pollen extracts into the peritoneal cavity of actively immunized mice caused an accumulation of eosinophils in the cavity. We investigated the role of interleukin-5 (IL-5), one of the T-cell-derived factors, in this in vivo local accumulation. Ciclosporin, an immunosuppressant that mainly suppresses T cell functions, dose-dependently inhibited the in vivo local accumulation. Injections of the neutralizing antibody to IL-5 into the cavity decreased the number of the accumulating eosinophils. When the peritoneal cells of the immunized mice were cultured in the presence of the antigen in vitro, IL-5 activity was detected in the culture supernatant. The results indicate that IL-5 plays an important role in the in vivo local accumulation of eosinophils after an antigen challenge.
authors.affiliation: Basic Research Laboratories, Toray Industries Inc., Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Hitoshi
authors.forename: K
authors.initials: K
authors.lastname: Takatsu
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
mesh_terms: D000485:Allergens / Q000008:administration & dosage; D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage; D004804:Eosinophils / Q000276:immunology*; D015848:Interleukin-5 / Q000096:biosynthesis / Q000276:immunology*; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000276:immunology; D010529:Peritoneal Cavity; D010538:Peritonitis / Q000276:immunology*; D011058:Pollen
chemical_list: D000485:Allergens; D015848:Interleukin-5; D016572:Cyclosporine