title: [A case of sarcoid granulomatous interstitial nephritis improved by steroid therapy].
abstract: We report a case of sarcoid granulomatous tubulointerstitial nephritis diagnosed by renal biopsy. A 60-year-old man presented with productive cough, and exertional dyspnea of 3 months duration. A chest X-ray film revealed diffuse reticulonodular infiltrates in both lung fields. A transbronchial lung biopsy specimen showed inflammation of the alveolar septum associated with non-caseating granulomas. The patient also had tubular proteinuria and glucosuria. Ga-scintigraphy demonstrated an abnormal accumulation of gallium in both lungs and kidneys. Renal function tests revealed tubular dysfunction. Tubulointerstitial nephropathy was suspected. A renal biopsy specimen exhibited tubulointerstitial nephritis associated with numerous non-caseating granulomas, similar to the findings of the lung biopsy specimen. No glomerular abnormalities were evident. Later, a scalene node biopsy confirmed the diagnosis of sarcoidosis. Prednisolone therapy yielded a favorable outcome for both the renal and pulmonary involvement. During the corticosteroid therapy, measurement of the urinary beta-2-microglobulin concentration proved a valuable monitoring tool for assessing the recovery of the tubular impairment.
authors.affiliation: Second Department of Internal Medicine, University of Occupational Environmental health, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Matsuo
authors.forename: K
authors.initials: K
authors.lastname: Yu
authors.forename: O
authors.initials: O
authors.lastname: Hasegawa
authors.forename: M
authors.initials: M
authors.lastname: Takasugi
authors.forename: A
authors.initials: A
authors.lastname: Kuroiwa
authors.forename: A
authors.initials: A
authors.lastname: Kajiki
authors.forename: N
authors.initials: N
authors.lastname: Miyazaki
authors.forename: M
authors.initials: M
authors.lastname: Kido
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000150:complications
chemical_list: D011239:Prednisolone