title: Factors influencing the healing of distal amputations performed for lower limb ischaemia.
abstract: A total of 235 toes were amputated during 125 operations on 100 consecutive patients with lower limb ischaemia. The overall amputation wound healing rate for the series was 58.4 per cent and limb salvage was achieved in 66 patients. Toe amputation was performed under local anaesthesia in 57 cases and 32 (56 per cent) of these healed primarily, not significantly different from the healing rate of 41 (60 per cent) of 68 under general anaesthesia. Reconstructive arterial surgery was performed in conjunction with toe amputation in 39 patients; the healing rate with reconstruction was 32 (82 per cent) of 39, significantly better than the 41 (48 per cent) of 86 patients not undergoing bypass surgery (P less than 0.001). There was no difference in healing rates when comparing diabetic and non-diabetic patients. Multiple regression analysis demonstrated that reconstructive arterial surgery was the only factor which had an independent and significant influence on toe amputation healing. The use of local anaesthesia for distal amputation has no deleterious effects on wound healing.
authors.affiliation: Department of Surgery, Derbyshire Royal Infirmary, UK.
authors.forename: R L
authors.initials: RL
authors.lastname: Byrne
authors.forename: M L
authors.initials: ML
authors.lastname: Nicholson
authors.forename: T J
authors.initials: TJ
authors.lastname: Woolford
authors.forename: K G
authors.initials: KG
authors.lastname: Callum
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000671:Amputation, Surgical; D000772:Anesthesia, Local; D001158:Arteries / Q000601:surgery; D003925:Diabetic Angiopathies / Q000150:complications; D005260:Female; D006801:Humans; D007511:Ischemia / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D012044:Regression Analysis; D012189:Retrospective Studies; D014034:Toes / Q000098:blood supply*; D014945:Wound Healing / Q000502:physiology*