title: Diffusion imaging of the human brain in vivo using high-speed STEAM MRI.
abstract: This paper describes a new method for diffusion imaging of the human brain in vivo that is based on a combination of diffusion-encoding gradients with high-speed STEAM MR imaging. The single-shot sequence 90 degrees-TE/2-90 degrees-TM-(alpha-TE/2-STE)n generates n = 32-64 differently phase-encoded stimulated echoes STE yielding image acquisition times of 576 ms for a 48 x 128 data matrix. Diffusion encoding is performed during the first TE/2-interval as well as during each readout period. Phantom studies reveal a quantitative agreement of calculated diffusion coefficients with literature values. EKG triggering completely eliminates motion artifacts from diffusion-weighted single-shot STEAM images of human brain in vivo. While signal attenuation of the cerebrospinal fluid (CSF) is predominantly due to flow, that observed for gray and white matter results from diffusion. Evaluated diffusion coefficients yield (1.0 +/- 0.1) x 10(-5) cm2 s-1 for gray matter, (0.5 +/- 0.1) x 10(-5) cm2 s-1 for white matter with the diffusion encoding parallel to the main orientation of the myelin sheath of the neurofibrils, and (0.3 +/- 0.1) x 10(-5) cm2 s-1 for white matter and a perpendicular orientation. All studies were performed at 2.0 T using a conventional 10 mT m-1 gradient system.
authors.affiliation: Max-Planck-Institut für biophysikalische Chemie, Göttingen, Federal Republic of Germany.
authors.forename: K D
authors.initials: KD
authors.lastname: Merboldt
authors.forename: W
authors.initials: W
authors.lastname: Hänicke
authors.forename: H
authors.initials: H
authors.lastname: Bruhn
authors.forename: M L
authors.initials: ML
authors.lastname: Gyngell
authors.forename: J
authors.initials: J
authors.lastname: Frahm
mesh_terms: D001921:Brain / Q000033:anatomy & histology*; D004058:Diffusion; D004121:Dimethyl Sulfoxide; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008961:Models, Structural; D009068:Movement; D011092:Polyethylene Glycols; D013997:Time Factors; D014867:Water
chemical_list: D014867:Water; D011092:Polyethylene Glycols; D004121:Dimethyl Sulfoxide