title: Intrathecal synthesis of soluble class I antigens in multiple sclerosis.
abstract: We have studied the intrathecal synthesis of soluble class I antigens (sHLA), reflected by the index IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin), in multiple sclerosis (MS). IH was increased in patients in relapse, but normal in patients in remission; these findings show that there is a high lymphocyte activation within the central nervous system in patients with clinically active MS.
authors.affiliation: Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Alvarez-Cermeño
authors.forename: L M
authors.initials: LM
authors.lastname: Villar
authors.forename: M
authors.initials: M
authors.lastname: Nocito
authors.forename: A
authors.initials: A
authors.lastname: Bootello
authors.forename: P
authors.initials: P
authors.lastname: González-Porqué
mesh_terms: D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier; D005260:Female; D006680:HLA Antigens / Q000032:analysis / Q000134:cerebrospinal fluid; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid; D012995:Solubility
chemical_list: D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I