Parathyroid hypertensive factor is present in DOCA-salt but not two-kidney-one-clip hypertensive rats.
In order to determine whether the expression of parathyroid hypertensive factor (PHF) is secondary to hypertension or whether it is specifically related to low-renin hypertension, PHF levels were measured in DOCA-salt and two-kidney-one-clip (2K-1C) hypertensive rats. Despite equivalent elevations of blood pressure, PHF was detected in the DOCA-salt rats, but not in the 2K-1C rats (17.5 +/- 3.1 mm Hg, P less than .0001 v 0.9 +/- 2.8 mm Hg, P = NS, respectively). Moreover, PHF levels correlated with mean arterial pressure in the DOCA-salt group (r = 0.91, P less than .0001). We conclude that PHF expression is not a secondary phenomenon caused by hypertension, but rather may be causally related to the development of low-renin forms of hypertension.
Lewanczuk
R Z
RZ
Department of Physiology, University of Alberta, Edmonton, Canada.
Pang
P K
PK
D000818:Animals; D001685:Biological Factors / Q000097:blood*; D001794:Blood Pressure / Q000502:physiology; D003900:Desoxycorticosterone; D006973:Hypertension / Q000097:blood* / Q000139:chemically induced; D006978:Hypertension, Renovascular / Q000097:blood* / Q000503:physiopathology; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY; D012083:Renin / Q000097:blood; D012982:Sodium, Dietary / Q000009:adverse effects
D001685:Biological Factors; D012982:Sodium, Dietary; C064505:parathyroid hypertensive factor; D003900:Desoxycorticosterone; D012083:Renin