title: Relationships between plasma lipoproteins and glucose in fasted chickens selected for leanness or fatness by three criteria.
abstract: In order to identify the mechanisms which underlie fattening in commercial birds, lean and fat broiler chickens have been selected according to 3 different criteria: abdominal fat content, plasma glucose level and plasma concentration of very-low-density lipoproteins (VLDL), the latter being the main substrate from which bird adipose tissues accumulate triglycerides. Chickens selected for high abdominal fat content displayed a higher level of VLDL and a lower level of glucose than their lean counterparts. Conversely, selection for high plasma VLDL or low plasma glucose resulted in 2 fat lines of chickens. The differences in intermediate- and low-density lipoproteins reflected a different balance in synthesis and catabolism of VLDL among the lines, whereas there was no difference in high-density lipoproteins. These data clearly demonstrate the relationship between lipid and carbohydrate metabolism and their role in the susceptibility to fattening. They suggest a greater use of carbohydrate for hepatic lipogenesis in fat chickens, resulting in a higher synthesis and secretion of VLDL and of their subsequent accumulation of triglycerides in the adipose tissue.
authors.affiliation: INSERM Unité 321, Pavillon B Delessert, Hôpital de la Pitié, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Hermier
authors.forename: M R
authors.initials: MR
authors.lastname: Salichon
authors.forename: C C
authors.initials: CC
authors.lastname: Whitehead
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001823:Body Composition / Q000235:genetics; D001947:Breeding; D002645:Chickens / Q000033:anatomy & histology / Q000097:blood* / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol