Hyperemesis gravidarum: a case report suggesting new concepts and research needs.
Hyperemesis gravidarum has been considered an emotional disorder. Recent studies suggest that reflux esophagitis in combination with gastric dysrhythmias causes hyperemesis. A 10-week-pregnant 28-year-old woman treated successfully with antiemetics was shown to have fluctuations in gastric pH consistent with gastric dysrhythmia and reflux. Although drugs with antiemetic activity give symptomatic improvement, further research is needed to discover safe medications to treat the underlying gastric dysrhythmia.
Devitt
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NF
Department of Family, University of New Mexico School of Medicine.
D000932:Antiemetics / Q000627:therapeutic use; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology; D005767:Gastrointestinal Diseases / Q000150:complications; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy
D000932:Antiemetics