The effects of thiamine and EDTA on biliary and urinary lead excretion in sheep.
Relative efficacy of thiamine (B1) and/or calcium disodium ethylinediaminetetraacetate (EDTA) administration on lead (Pb) excretion via bile and urine was studied in Pb-loaded sheep. The sheep were administered B1 s.c., 75 mg/kg body wt., EDTA i.v., 110 mg/kg body wt., and a combination of B1-EDTA at rates as above. Each treatment was followed by 69 h sampling of blood, bile, and urine. Urinary Pb excretion increased following B1-EDTA greater than EDTA greater than B1 administration. Thiamine and B1-EDTA treatments increased biliary Pb excretion. Overall, B1, EDTA and B1-EDTA administration increased Pb excretion via bile and urine by 72%, 595%, and 842% respectively over basal level (mean +/- SE: 20.1 +/- 2.9 micrograms Pb/h). It has been concluded that thiamine enhances elimination of Pb from the body and this feature may be beneficial in chelation therapy.
Olkowski
A A
AA
Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada.
Gooneratne
S R
SR
Christensen
D A
DA
D000818:Animals; D001646:Bile / Q000737:chemistry*; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007279:Injections, Subcutaneous; D007855:Lead Poisoning / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D012756:Sheep; D013831:Thiamine / Q000008:administration & dosage / Q000627:therapeutic use*
D004492:Edetic Acid; D013831:Thiamine