Antiulcerogenic effects of two Maytenus species in laboratory animals.
Leaves of Maytenus species are commonly used in Brazil for the treatment of gastric ulcers, dyspepsias and other gastric problems. The present study evaluated the antiulcerogenic potential of a boiling water extract of equal parts of M. aquifolium and M. ilicifolia leaves against ulcer lesions induced by indomethacin and cold-restraint stress in rats. Ranitidine and cimetidine were used as reference drugs. The oral and intraperitoneal administration of the extract had a potent antiulcerogenic effect against both types of ulcers. The extract was shown to cause an increase in volume and pH of gastric juice of the animals with the pH effects comparable to those of cimetidine. The results tend to confirm the popular use of the plant.
Souza-Formigoni
M L
ML
Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.
Oliveira
M G
MG
Monteiro
M G
MG
da Silveira-Filho
N G
NG
Braz
S
S
Carlini
E A
EA
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000032:analysis / Q000494:pharmacology*; D001938:Brazil; D002927:Cimetidine / Q000627:therapeutic use; D003080:Cold Temperature; D005744:Gastric Acid / Q000378:metabolism; D007213:Indomethacin / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D002927:Cimetidine; D007213:Indomethacin