Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy.
Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.
Schiff
E
E
Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer, Israel.
Shalev
E
E
Bustan
M
M
Tsabari
A
A
Mashiach
S
S
Weiner
E
E
D000028:Abortion, Induced; D000328:Adult; D005187:Fallopian Tubes; D005260:Female; D005865:Gestational Age; D006801:Humans; D007267:Injections; D008657:Metabolic Clearance Rate; D008727:Methotrexate / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011247:Pregnancy; D011271:Pregnancy, Ectopic
D008727:Methotrexate