Prolonged survival of skin grafts following treatment with an antibody to a putative cell triggering molecule, QCA-1.
The QCA-1 molecule (quiescent cell antigen-1) appears to be involved in the differentiation events undergone by T cell following occupancy of the antigen receptor. Here we show that modulation of the QCA-1 antigen from the surface of the cell normally follows activation, and that treatment of animals with the antibodies against the QCA-1 molecule inhibits the normal response to an allograft without appearing to alter the number of peripheral T cells or the expression by these cells of the alpha/beta T cell antigen receptor.
Aspinall
R
R
Quadrant, Trumpington, Cambridge, GB.
Kampinga
J
J
Van den Bogaerde
J
J
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D006085:Graft Survival; D007518:Isoantibodies / Q000276:immunology; D008213:Lymphocyte Activation; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000954:Antigens, Surface; D015704:CD4 Antigens; D007518:Isoantibodies; C072025:quiescent cell antigen-1