Mapping of Fc gamma receptors in the human and porcine eye.
By using an immunohistochemical technique, we detected a strong reaction product for Fc gamma receptors in the keratoconjunctival epithelium, uveal trabecular meshwork, optic nerve, and muscle walls of the retinal and ciliary vessels of infant human eyes; moderate staining was seen on the corneal endothelium, corneoscleral trabecular meshwork, non-pigmented ciliary epithelium, ciliary muscle fibers, endothelial lining of ocular blood vessels, as well as the anterior region of Muller cells, the outer nuclear layer, and pigment epithelium of the retina. In aged human and porcine eyes, the same structures stained somewhat less intensely than did those in infant human tissues. Primary cultures of porcine trabecular cells demonstrated a more intense immunoreaction product than did tertiary cultures. We discuss the possible role of Fc gamma receptors in various ocular inflammatory conditions and the implications of age-dependent expression by human trabecular cells in the pathogenesis of open-angle glaucoma.
Tripathi
R C
RC
Visual Sciences Center, University of Chicago, IL 60637.
Borisuth
N S
NS
Tripathi
B J
BJ
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001667:Binding, Competitive; D002478:Cells, Cultured; D005123:Eye / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007142:Immunoglobulin gamma-Chains / Q000276:immunology; D007223:Infant; D011961:Receptors, Fc / Q000032:analysis*; D013552:Swine; D014018:Tissue Distribution
D007074:Immunoglobulin G; D007142:Immunoglobulin gamma-Chains; D011961:Receptors, Fc