Hemodilution and revascularization for early treatment of stroke: an experimental trial.
A new experimental trial to investigate the usefulness of early therapeutic measures in case of acute I.V.D. has been performed, on the basis of a previous already reported experience. A combined treatment consisting of hemodilution and revascularization starting 16 hours after the onset of cerebral ischemia was tested. The study was performed in a population of 20 New Zealand male rabbits in which an acute cerebral ischemia was achieved by means of extracranial ligation of both common carotid artery and of one vertebral artery. The animals were divided into two groups. 1st group: no treatment; 2nd group: revascularization + hemodilution. Better results were observed in treated group considering either CBF rates or histological changes.
Donzelli
R
R
Dipartimento di Patologia Sistematica, II Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli.
Spaziante
R
R
Cappabianca
P
P
Cafiero
T
T
Mariniello
G
G
de Divitiis
E
E
D000208:Acute Disease; D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology; D002548:Cerebral Revascularization; D002560:Cerebrovascular Circulation / Q000502:physiology; D002561:Cerebrovascular Disorders / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D006438:Hemodilution; D008297:Male; D011817:Rabbits