Protein tumor antigens.
Immunogenic tumor antigens have been sought through a variety of paradigms for several past decades. Recent developments in antigen presentation have radically changed the prism through which we view these enigmatic antigens. This article discusses the small but growing treasure chest of these antigens--stress-induced proteins, the P1AB antigen of the P815 mastocytoma, the p53 tumor suppressor protein, the gp95/p97 antigen of human melanoma, mucins and others.
Srivastava
P K
PK
Mount Sinai School of Medicine, New York.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis; D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology*; D015972:Gene Expression Regulation, Neoplastic; D006360:Heat-Shock Proteins / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014183:Transplantation, Heterologous; D016159:Tumor Suppressor Protein p53 / Q000276:immunology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D006360:Heat-Shock Proteins; D009363:Neoplasm Proteins; D016159:Tumor Suppressor Protein p53