title: Signet-ring chondrosarcoma: a new morphologic entity.
abstract: A 65-year-old, otherwise healthy white man presenting with an asymptomatic anterior chest wall mass diagnosed from a routine preoperative chest x-ray is reported. A fine needle aspirate of the mass was initially interpreted as a metastatic adenocarcinoma with prominent "signet-ring" features, but ultrastructural study of the cell block later suggested a chondrosarcoma. The resected surgical specimen confirmed the diagnosis of a grade 2 chondrosarcoma, with most of the tumor cells containing a large, clear, single vacuole shown to be lipid. The positive immunostaining for vimentin and S-100 as well as the ultrastructural appearance confirmed the diagnosis of a chondrosarcoma. Flow cytometric DNA analysis of the tumor on two separate occasions documented a very large aneuploid cell population (50% to 60%) which, when interpreted with the histologic appearance, suggested an aggressive tumor. This case illustrates the first published example of a "signet-ring" chondrosarcoma.
authors.affiliation: Department of Pathology, University of Calgary Faculty of Medicine, Alberta, Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Demetrick
authors.forename: P D
authors.initials: PD
authors.lastname: Kneafsey
authors.forename: W S
authors.initials: WS
authors.lastname: Hwang
mesh_terms: D000368:Aged; D002813:Chondrosarcoma / Q000473:pathology* / Q000648:ultrastructure; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D013899:Thoracic Neoplasms / Q000473:pathology* / Q000648:ultrastructure