title: Toxicity and tissue accumulation of copper in chicks fed casein and soy-based diets.
abstract: Experiments were conducted to study Cu toxicity in chicks fed casein or soy-containing diets containing graded levels of excess CuSO4.5H2O. Differences between diets in measures of Cu toxicity were pronounced. Addition of 800 mg of Cu/kg to a casein-dextrose semipurified diet decreased weight gains by 63%, but the same addition of Cu to a corn-soybean meal complex diet decreased gains by only 8%. At all levels of Cu supplementation (100, 200, 400 or 800 mg/kg), Cu deposition in the liver was increased markedly in chicks fed casein diets compared with those fed the complex diet. Substituting soy-protein concentrate for casein in the semipurified diet resulted in a marked decrease in Cu toxicity as measured by weight gain reductions and tissue accumulation of Cu.
authors.affiliation: Dept. of Anim. Sci., University of Illinois, Urbana 61801.
authors.forename: M A
authors.initials: MA
authors.lastname: Funk
authors.forename: D H
authors.initials: DH
authors.lastname: Baker
mesh_terms: D000818:Animals; D002364:Caseins / Q000008:administration & dosage*; D002645:Chickens / Q000378:metabolism*; D003300:Copper / Q000493:pharmacokinetics / Q000633:toxicity*; D004435:Eating; D008099:Liver / Q000378:metabolism; D008297:Male; D014674:Plant Proteins, Dietary / Q000008:administration & dosage*; D030262:Soybean Proteins; D013025:Glycine max; D015430:Weight Gain
chemical_list: D002364:Caseins; D014674:Plant Proteins, Dietary; D030262:Soybean Proteins; D003300:Copper