title: The role of glycation in aging and diabetes mellitus.
abstract: One of the hypotheses trying to explain the process of aging is the idea of glycation of proteins. This reaction, also called the Maillard or browning reaction, may explain age-related symptoms such as cataract, atherosclerosis and modification of collagen-containing tissues. Diabetics, which possess elevated blood sugar levels, show signs of accelerated aging exposing similar complications. The Maillard reaction, which occurs on a large scale in vivo, may play a key role in the initiation of these symptoms.
authors.affiliation: Department of Biochemistry, University of Nijmegen, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: van Boekel
mesh_terms: D000375:Aging / Q000378:metabolism*; D001161:Arteriosclerosis / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002386:Cataract / Q000209:etiology / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism; D003459:Crystallins / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism*; D006801:Humans; D007526:Isoelectric Point; D015416:Maillard Reaction; D009696:Nucleic Acids / Q000378:metabolism; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism*; D012545:Schiff Bases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D003459:Crystallins; D009696:Nucleic Acids; D011506:Proteins; D012545:Schiff Bases; D003094:Collagen