title: A simple method for global sequence comparison.
abstract: A simple method of sequence comparison, based on a correlation analysis of oligonucleotide frequency distributions, is here shown to be a reliable test of overall sequence similarity. The method does not involve sequence alignment procedures and permits the rapid screening of large amounts of sequence data. It identifies those sequences which deserve more careful analysis of sequence similarity at the level of resolution of the single nucleotide. It uses observed quantities only and does not involve the adoption of any theoretical model.
authors.affiliation: Centro Studi Mitocondri e Metabolismo Energetico CNR, Dipartimento di Biochimica e Biologia Molecolare, University of Bari, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Pizzi
authors.forename: M
authors.initials: M
authors.lastname: Attimonelli
authors.forename: S
authors.initials: S
authors.lastname: Liuni
authors.forename: C
authors.initials: C
authors.lastname: Frontali
authors.forename: C
authors.initials: C
authors.lastname: Saccone
mesh_terms: D000465:Algorithms; D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D016208:Databases, Factual; D016678:Genome; D006801:Humans; D008433:Mathematics; D008969:Molecular Sequence Data; D009841:Oligonucleotides / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D012984:Software
chemical_list: D009841:Oligonucleotides