[Prevention and correction with nonopiate analog of leu-enkephalin of disorders induced in the liver of newborn white rats by prenatal hypoxia].
The newborn rats after 48 hours after the birth were used in the study. The prenatal hypoxia caused the development of hypotrophy. Index of labeled 3H-thymidine nuclei decreased 1.5 fold, mitotic index decreased 1.4 fold. The content of aberrant figures of mitosis increased 2.6 times. Hexapeptide injection before hypoxia reduced the alterations caused by hypoxia, the data of body and liver weight did not differ from the control level.
Utkina
L I
LI
Timoshin
S S
SS
D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000627:therapeutic use*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005311:Fetal Hypoxia / Q000150:complications*; D008099:Liver / Q000033:anatomy & histology; D008107:Liver Diseases / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D009929:Organ Size; D051381:Rats; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D014810:Vitamin E; D016308:Enkephalin, Leucine-2-Alanine
Profilaktika i korrektsiia s pomoshch'iu neopiatnogo analoga leĭ-énkefalina narusheniĭ, indutsiruemykh v pecheni potomstva belykh krys prenatal'noĭ gipoksieĭ.