title: Assessment of medial thinning in atherosclerosis by intravascular ultrasound.
abstract: This study investigated the in vitro (40 MHz) and in vivo (30 MHz) feasibility of intravascular ultrasound to document the influence of atherosclerotic lesions on the typical 3-layered appearance of muscular arteries. The in vitro images of 39 arteries were compared with the corresponding histologic sections. Media and lesion thickness were measured at the areas of minimal and maximal lesion thickness. The median media thickness was 0.8 mm in the absence of a lesion, decreasing to 0.3 mm in the area of maximal atherosclerosis. The ultrasonic data correlated closely with histologic measurements (0.6 and 0.3 mm, respectively). The in vivo study was performed in 29 patients undergoing coronary or peripheral vascular procedures. A total of 150 still-frames were selected for quantitative analysis. The median media thickness was 0.6 mm in the absence of a lesion, decreasing to 0.1 mm in the area with maximal atherosclerosis. This study revealed that intravascular ultrasound imaging accurately determines that media thickness of muscular arteries is inversely related to lesion thickness. In vitro data, verified with histology, can be translated to humans in vivo.
authors.affiliation: Department of Pathology, University Hospital Rotterdam, Erasmus University, Rotterdam, The Netherlands.
authors.forename: E J
authors.initials: EJ
authors.lastname: Gussenhoven
authors.forename: P A
authors.initials: PA
authors.lastname: Frietman
authors.forename: S H
authors.initials: SH
authors.lastname: The
authors.forename: R J
authors.initials: RJ
authors.lastname: van Suylen
authors.forename: F C
authors.initials: FC
authors.lastname: van Egmond
authors.forename: C T
authors.initials: CT
authors.lastname: Lancée
authors.forename: H
authors.initials: H
authors.lastname: van Urk
authors.forename: J R
authors.initials: JR
authors.lastname: Roelandt
authors.forename: T
authors.initials: T
authors.lastname: Stijnen
authors.forename: N
authors.initials: N
authors.lastname: Bom
mesh_terms: D001158:Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D002114:Calcinosis / Q000000981:diagnostic imaging; D002118:Calcium; D002406:Catheterization, Peripheral; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000473:pathology; D008722:Methods; D009132:Muscles / Q000098:blood supply; D012044:Regression Analysis; D014463:Ultrasonography; D014741:Video Recording
chemical_list: D002118:Calcium