Comparing core needle to surgical biopsies in breast cancer for cell kinetic and ploidy studies.
The evaluability and reliability of proliferative activity (expressed as 3H-thymidine labeling index, 3H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of 3H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between 3H-TdR LI values in the 16 cases with both evaluable determinations was poor (rs = 0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (rs = 0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.
Daidone
M G
MG
Division of Oncologia Sperimentale C, Istituto Nazionale Tumori, Milan, Italy.
Orefice
S
S
Mastore
M
M
Santoro
G
G
Salvadori
B
B
Silvestrini
R
R
D001706:Biopsy / Q000379:methods*; D001707:Biopsy, Needle / Q000379:methods*; D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D002455:Cell Division / Q000502:physiology; D004273:DNA, Neoplasm / Q000032:analysis / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007700:Kinetics; D011003:Ploidies; D015203:Reproducibility of Results; D013936:Thymidine / Q000378:metabolism
D004273:DNA, Neoplasm; D013936:Thymidine