Anti-neoplastic glucuronide prodrug treatment of human tumor cells targeted with a monoclonal antibody-enzyme conjugate.
Roffler
S R
SR
Institute of Biomedical Sciences, Academia Sinica Taipei, Taiwan, R.O.C.
Wang
S M
SM
Chern
J W
JW
Yeh
M Y
MY
Tung
E
E
D000816:Aniline Mustard / Q000031:analogs & derivatives* / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000276:immunology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004789:Enzyme Activation; D005966:Glucuronidase / Q000494:pharmacology; D006801:Humans; D011355:Prodrugs / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000276:immunology
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D011355:Prodrugs; C071879:p-hydroxyaniline mustard glucuronide, tetra-n-butyl ammonium salt; C000929:hydroxyaniline mustard; D000816:Aniline Mustard; D005966:Glucuronidase