Dopaminergic and ligand-independent activation of steroid hormone receptors.
The current view of how steroid hormone receptors affect gene transcription is that these receptors, on binding ligand, change to a state in which they can interact with chromatin and regulate transcription of target genes. Receptor activation is believed to be dependent only on this ligand-binding event. Selected steroid hormone receptors can be activated in a ligand-independent manner by a membrane receptor agonist, the neurotransmitter dopamine. In vitro, dopamine faithfully mimicked the effect of progesterone by causing a translocation of chicken progesterone receptor (cPR) from cytoplasm to nucleus. Dual activation by progesterone and dopamine was dissociable, and a serine residue in the cPR was identified that is not necessary for progesterone-dependent activation of cPR, but is essential for dopamine activation of this receptor.
Power
R F
RF
Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030.
Mani
S K
SK
Codina
J
J
Conneely
O M
OM
O'Malley
B W
BW
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000502:physiology; D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D004298:Dopamine / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D004873:Ergolines / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008024:Ligands; D009638:Norepinephrine / Q000494:pharmacology; D019319:Okadaic Acid; D011401:Promoter Regions, Genetic; D019257:Quinpirole; D011954:Receptors, Dopamine / Q000502:physiology*; D011987:Receptors, Steroid / Q000502:physiology*; D012045:Regulatory Sequences, Nucleic Acid; D015398:Signal Transduction; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000187:drug effects
D004873:Ergolines; D004988:Ethers, Cyclic; D008024:Ligands; D011954:Receptors, Dopamine; D011987:Receptors, Steroid; D014157:Transcription Factors; D019319:Okadaic Acid; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D000262:Adenylyl Cyclases; D007545:Isoproterenol; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine