title: [Characteristics of the first penicillinase-producing strains of Neisseria gonorrhoeae isolated in Tunisia].
abstract: The first penicillinase-producing strain of Neisseria gonorrhoeae was recently isolated in Tunisia (1989). Betalactamase production was detected by the iodometric agar test. Minimal inhibitory concentrations (MICs) in agar medium were 128 micrograms/ml for penicillin, ampicillin and amoxycillin. With the amoxycillin-clavulanic acid combination, MIC fell to 0.25 microgram/ml. An Asian-type plasmid pattern was evidenced in this strain, with presence of the 2.6 Mdal cryptic plasmid and of a 4.5 Mdal plasmid.
authors.affiliation: Laboratoire de Bactériologie, Institut Pasteur de Tunis, Tunis Belvédère.
authors.forename: A
authors.initials: A
authors.lastname: Kechrid
authors.forename: H
authors.initials: H
authors.lastname: Karoui
authors.forename: S
authors.initials: S
authors.lastname: Ben Rejeb
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D010405:Penicillinase / Q000378:metabolism*; D010957:Plasmids; D014416:Tunisia; D001618:beta-Lactamases / Q000032:analysis
chemical_list: D010405:Penicillinase; D001618:beta-Lactamases
vernacular_title: Caractéristiques de la 1re souche de Neisseria gonorrhoeae productrice de pénicillinase isolée en Tunisie.