title: Distensibility of small arteries of the dog lung.
abstract: To obtain in situ measurements of the distensibility of small (100- to 1,000-microns-diam) pulmonary arterial vessels of the dog lung, X-ray angiograms were obtained from isolated lung lobes with the vascular pressure adjusted to various levels. The in situ diameter-pressure relationships were compared with the diameter-pressure relationships for small arteries that were dissected free from the lungs and cannulated with small glass pipettes for the measurement of diameter and transmural pressure. The diameter-vascular or diameter-transmural pressure curves from both in situ and cannulated vessels were sufficiently linear in the pressure range studied (0-30 Torr) that they could be characterized by linear regression to obtain estimates of D0, the diameter at zero vascular pressure, and beta, the change in diameter (micron) per Torr change in pressure. The vessel distensibility coefficient (alpha) was defined as alpha = beta/D0. The mean values of alpha were approximately 2.0 +/- 0.8%/Torr (SD) for the in situ vessels and 1.7 +/- 0.6%/Torr for the cannulated vessels, with no statistically significant difference between the two methods. The influence of vasoconstriction elicited by serotonin was evaluated in the in situ vessels. Serotonin-induced vasoconstriction caused a decrease in D0 and little change in alpha.
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee 53225.
authors.forename: A
authors.initials: A
authors.lastname: al-Tinawi
authors.forename: J A
authors.initials: JA
authors.lastname: Madden
authors.forename: C A
authors.initials: CA
authors.lastname: Dawson
authors.forename: J H
authors.initials: JH
authors.lastname: Linehan
authors.forename: D R
authors.initials: DR
authors.lastname: Harder
authors.forename: D A
authors.initials: DA
authors.lastname: Rickaby
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D066298:In Vitro Techniques; D010477:Perfusion; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D011652:Pulmonary Circulation; D011859:Radiography; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D012701:Serotonin