title: [Infectious chemoprophylaxis in colorectal surgery. A multicenter study of imipenem-cilastatin vs. cefuroxime and metronidazole or cefotetan].
abstract: The authors report the results of a multicentric clinical study on prevention of surgical infections in colorectal surgery by chemo-antibiotic prophylaxis. This trial was carried on to evaluate the effect of imipenem-cilastatin (1 g i.v. just before operation and 1 g i.v. 3 hours from surgical procedure) vs. cefuroxime + metronidazole (1.5 g + 0.25 g i.v.) or cefotetan (1 g i.v.) given with the same modalities. In 48 patients undergoing colorectal resection (47 with malignant neoplastic disease) 24 were treated with imipenem, 18 with cefuroxime and 6 with cefotetan. In group A (imipenem-cilastatin) the infection rate was 4.2% (1/24 cases), in group B (cefuroxime + metronidazole or cefotetan) postoperative infections were registered in 4 out of 24 cases (16.6%). This study documented the good results of systemic chemoprophylaxis and the great efficacy of imipenem-cilastatin in colorectal surgery.
authors.affiliation: Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi di Ferrara.
authors.forename: A
authors.initials: A
authors.lastname: Sortini
authors.forename: G
authors.initials: G
authors.lastname: Liguori
authors.forename: R
authors.initials: R
authors.lastname: Bardini
authors.forename: A
authors.initials: A
authors.lastname: Infantino
authors.forename: G
authors.initials: G
authors.lastname: Carrella
authors.forename: A
authors.initials: A
authors.lastname: Asolati
mesh_terms: D015313:Cefotetan / Q000627:therapeutic use*; D002444:Cefuroxime / Q000627:therapeutic use*; D015377:Cilastatin / Q000627:therapeutic use*; D003106:Colon / Q000601:surgery*; D004359:Drug Therapy, Combination; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D007558:Italy / Q000453:epidemiology; D008795:Metronidazole / Q000627:therapeutic use*; D011292:Premedication; D012007:Rectum / Q000601:surgery*; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D008795:Metronidazole; D015377:Cilastatin; D015313:Cefotetan; D015378:Imipenem; D002444:Cefuroxime
vernacular_title: Chemioprofilassi infettiva in chirurgia colo-rettale. Studio policentrico su imipenem-cilastatina vs. cefuroxime e metronidazolo o cefotetan.