title: [Adrenocortical nodular hyperplasia as a cause of Cushing syndrome in the neonatal period].
abstract: The case report of a female child born preterm (30th wk of gestation) who developed symptoms of Cushing's syndrome beginning in the neonatal phase is presented. The disease was caused by a unilateral adreno-cortical nodular hyperplasia and was successfully treated by unilateral adrenalectomy. Preoperative treatment with ketoconazole and metyrapone proved to be effective. Symptoms of Cushing's disease including hypertrophic cardiomyopathy were completely reversible within one month after surgery.
authors.affiliation: Abteilung Kinderheilkunde II, Universität Tübingen.
authors.forename: P
authors.initials: P
authors.lastname: Gessler
authors.forename: M B
authors.initials: MB
authors.lastname: Ranke
authors.forename: H
authors.initials: H
authors.lastname: Wollmann
authors.forename: K P
authors.initials: KP
authors.lastname: Aicher
authors.forename: U
authors.initials: U
authors.lastname: Feine
authors.forename: E
authors.initials: E
authors.lastname: Kaiserling
authors.forename: C
authors.initials: C
authors.lastname: Leriche
authors.forename: E
authors.initials: E
authors.lastname: Steil
mesh_terms: D000312:Adrenal Hyperplasia, Congenital / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D000315:Adrenalectomy; D003480:Cushing Syndrome / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D007654:Ketoconazole / Q000008:administration & dosage; D008797:Metyrapone / Q000008:administration & dosage; D011300:Preoperative Care
chemical_list: D007654:Ketoconazole; D008797:Metyrapone
vernacular_title: Adreno-corticale noduläre Hyperplasie als Ursache eines Cushing-Syndroms in der Neugeborenenperiode.