title: Pulmonary performance of elderly normal subjects and subjects with chronic obstructive pulmonary disease exposed to 0.3 ppm nitrogen dioxide.
abstract: Symptoms and changes in pulmonary function of subjects with chronic obstructive pulmonary disease (COPD) and elderly normal subjects, induced by a 4-h exposure to 0.3 ppm NO2, were investigated using a double-blind, crossover design with purified air. The 5-day experimental protocol required approximately 2 wk with at least a 5-day separation between randomized 4-h exposures to either NO2 or air which included several periods of exercise. Over a 2-yr period, COPD subjects, all with a history of smoking, consisting of 13 men and 7 women (mean age of 60.0 yr) and 20 elderly normal subjects of comparable age and sex were evaluated. During intermittent light exercise, COPD subjects demonstrated progressive decrements in FVC and FEV1 compared with baseline with 0.3 ppm NO2, but not with air. Differences in percent changes from baseline data (air-NO2) showed an equivocal reduction in FVC by repeated measures of analysis of variance and cross-over t tests (p less than 0.10). Subgroup analyses suggested that responsiveness to NO2 decreased with severity of COPD; in elderly normal subjects, NO2-induced reduction in FEV1 was greater among smokers than never-smokers. A comparison of COPD and elderly normal subjects also revealed distinctions in NO2-induced responsiveness.
authors.affiliation: Department of Biophysics, University of Rochester Medical Center, NY 14642.
authors.forename: P E
authors.initials: PE
authors.lastname: Morrow
authors.forename: M J
authors.initials: MJ
authors.lastname: Utell
authors.forename: M A
authors.initials: MA
authors.lastname: Bauer
authors.forename: A M
authors.initials: AM
authors.lastname: Smeglin
authors.forename: M W
authors.initials: MW
authors.lastname: Frampton
authors.forename: C
authors.initials: C
authors.lastname: Cox
authors.forename: D M
authors.initials: DM
authors.lastname: Speers
authors.forename: F R
authors.initials: FR
authors.lastname: Gibb
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000393:Air Pollutants / Q000009:adverse effects; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009585:Nitrogen Dioxide / Q000009:adverse effects*; D012016:Reference Values; D015656:Respiratory Mechanics / Q000187:drug effects*; D012907:Smoking; D014797:Vital Capacity
chemical_list: D000393:Air Pollutants; D009585:Nitrogen Dioxide