title: Powdered alumina implants in the experimental animal: a histological study conducted in the rat.
abstract: The authors present a histological study conducted in the rat after powdered alumina implantation in the subcutis, the muscle and the peritoneum. After two weeks the same intense acute inflammatory reaction was observed in all of the implantation sites. After eight weeks the inflammatory reaction had regressed: there was a thin layer of connective tissue around the implant, completely isolating it from the surrounding tissues.
authors.affiliation: Istituto Ortopedico Rizzoli, Bologna.
authors.forename: M
authors.initials: M
authors.lastname: Di Silvestre
authors.forename: S
authors.initials: S
authors.lastname: Guizzardi
authors.forename: N
authors.initials: N
authors.lastname: Bettini
authors.forename: G
authors.initials: G
authors.lastname: Gargiulo
authors.forename: R
authors.initials: R
authors.lastname: Savini
mesh_terms: D000537:Aluminum Oxide / Q000633:toxicity*; D000818:Animals; D008422:Materials Testing; D009132:Muscles / Q000187:drug effects / Q000473:pathology; D010537:Peritoneum / Q000473:pathology; D011208:Powders; D019736:Prostheses and Implants / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
chemical_list: D011208:Powders; D000537:Aluminum Oxide