[Expression of the pro-opiomelanocortin gene in rats with inherited arterial hypertension].
Expression of pro-opiomelanocortin (POMC) gene in pituitary of rats from newly developed hypertensive strain (ISIAH strain) was studied by dot hybridization. The pUC8 plasmid containing 900 base pair (bp) segment or the human POMC gene corresponding to the major portion of the 3'-nontranslated mRNA region and 60 bp coding for the signal peptide, was used as a probe for hybridization. It was found that the expression of the POMC in pituitary of the hypertensive JSJAH rats was more than 3-fold gene lower as compared to normotensive Wistar strain. The latter is the original strain from which the ISIAH rats were bred. The mechanism of this phenomenon and its possible relation to the arterial hypertension are discussed.
Dashkevich
V S
VS
Pozdniakov
S G
SG
Markel'
A L
AL
Mertvetsov
N P
NP
D000818:Animals; D004195:Disease Models, Animal; D015870:Gene Expression / Q000502:physiology; D006973:Hypertension / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D011333:Pro-Opiomelanocortin / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics; D021382:Protein Sorting Signals / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D021382:Protein Sorting Signals; D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin
Osobennosti ékspressii gena proopiomelanokortina u krys s nasledstvenno obuslovlennoĭ arterial'noĭ gipertenzieĭ.