title: Alpha-thalassaemia: prevalence and pattern in northern Pakistan.
abstract: The level of Hb Bart's is directly related to the inheritance of alpha-thalassaemia gene. Hb electrophoresis for Hb Bart's in the cord blood is a very simple method of finding out the prevalence of alpha-thalassaemia gene in a given population. A study was, therefore, carried out to find out the prevalence of alpha-thalassaemia gene in the population of northern Pakistan by estimating the concentration of Hb Bart's in 500 cord blood samples during the period 1986-87 at AFIP Rawalpindi. Hb Bart's was detected in 12 neonates, thus indicating a rate of 2.4% of general population as carrier of alpha-thalassaemia gene. Two distinct groups were recognized. The first group was composed of 9 (75%) neonates, in which Hb Bart's levels varied between 2.0% to 3.5%, while the second group of 3 neonates (25%) showed a level of 5.8% to 6.3%. The former group was considered to be carrying alpha-thalassaemia-2 gene and the latter group as carrier of alpha-thalassaemia-1 gene. Neither Hb H disease nor Hb Bart's hydrops foetalis syndrome was detected in this series.
authors.affiliation: Haematology Department, Armed Forces Institute of Pathology, Rawalpindi.
authors.forename: Z
authors.initials: Z
authors.lastname: Rehman
authors.forename: M
authors.initials: M
authors.lastname: Saleem
authors.forename: A A
authors.initials: AA
authors.lastname: Alvi
authors.forename: M
authors.initials: M
authors.lastname: Anwar
authors.forename: P A
authors.initials: PA
authors.lastname: Ahmed
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
mesh_terms: D005260:Female; D006455:Hemoglobins, Abnormal / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010154:Pakistan / Q000453:epidemiology; D015995:Prevalence; D013789:Thalassemia / Q000097:blood / Q000453:epidemiology*
chemical_list: D006455:Hemoglobins, Abnormal; C030448:hemoglobin Bart's