title: A comprehensive analysis of the developmental and tissue-specific expression of the isoactin multigene family in the rat.
abstract: The present study represents the first comprehensive analysis of isoactin gene expression in the developing rat. Our results clearly demonstrate that the developmental and tissue-specific expression of the actin multigene family is a highly integrated and complex process involving a variety of regulatory paradigms. The distinct temporal patterns of expression reported in this study indicate that there are three key phases in the regulation of expression of the actin multigene family during development. These include early embryonic development, late fetal development, and early postnatal development. The specific spatial patterns of expression observed in this study demonstrate that the expression of the actin multigene family is much more permissive than previously reported. This permissive expression includes a wide range of "ectopic" expression of the striated muscle isoactins as well as an extended expression of the alpha-smooth muscle isoactin. These findings expand our current understanding of the expression of the actin multigene family in development and provide a fundamental basis for future studies directed at investigating these processes.
authors.affiliation: Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
authors.forename: K M
authors.initials: KM
authors.lastname: McHugh
authors.forename: K
authors.initials: K
authors.lastname: Crawford
authors.forename: J L
authors.initials: JL
authors.lastname: Lessard
mesh_terms: D000199:Actins / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D015139:Blotting, Southern; D003593:Cytoplasm / Q000502:physiology; D015870:Gene Expression; D005796:Genes; D006321:Heart / Q000502:physiology; D008969:Molecular Sequence Data; D005810:Multigene Family; D009130:Muscle, Smooth / Q000502:physiology; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats / Q000196:embryology / Q000235:genetics* / Q000254:growth & development
chemical_list: D000199:Actins; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger