Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate.
Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.
Aziz
T Z
TZ
Department of Cell and Structural Biology, University of Manchester Medical School, U.K.
Peggs
D
D
Sambrook
M A
MA
Crossman
A R
AR
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D008252:Macaca fascicularis; D009460:Neurologic Examination; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000503:physiopathology / Q000601:surgery*; D016634:Radiosurgery; D013787:Thalamic Nuclei / Q000503:physiopathology / Q000601:surgery*
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine