title: Cerebral protection during aneurysm surgery with isoflurane anesthesia. Technical note.
abstract: A strategy for intraoperative cerebral protection is described in which intraoperative electroencephalography is used to titrate the level of inspired isoflurane given for anesthesia to obtain isoelectricity prior to temporary vessel occlusion during repair of difficult aneurysms. During temporary vessel occlusion, arterial blood pressure is maintained or increased with an inotropic or vasopressor agent. After clipping of the aneurysm, the concentration of isoflurane is reduced to allow the patient to awaken in the operating room for early postoperative neurological examination. The combination of a high concentration of isoflurane, temporary vessel occlusion, and maintenance of arterial blood pressure may be a useful protective regimen during neurovascular procedures.
authors.affiliation: Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota.
authors.forename: F B
authors.initials: FB
authors.lastname: Meyer
authors.forename: D A
authors.initials: DA
authors.lastname: Muzzi
mesh_terms: D000768:Anesthesia, General / Q000379:methods*; D001921:Brain / Q000187:drug effects; D003250:Constriction; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery*; D007530:Isoflurane / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
chemical_list: D007530:Isoflurane