[The antiphlogistic effect of the ginkgolide BN 52 021 in the chemically burned rabbit eye].
BN 52 021, a specific antagonist of PAF receptors, was tested in the early-phase treatment of chemically burned eyes in 30 rabbits. The local application of BN 52 021 eyedrops-1% (water-soluble preparation, 5 times daily, in comparison with the other eye as a control) led to a visible anti-inflammatory effect (microscopically and macroscopically) of the chemically burned anterior eye segment. There was only a moderate increase of the concentration of PGF2 alpha after the chemical burn. The use of specific PAF antagonists seems to have a real chance for treatment of inflammatory reactions of the anterior eye segment. A combination with other mediator antagonists should be tested in further experiments.
Struck
H G
HG
Klinik und Poliklinik für Augenkrankheiten, Martin-Luther-Universität Halle-Wittenberg.
Geiser
H
H
Taube
C
C
Block
H U
HU
Mest
H J
HJ
Tost
M
M
D000818:Animals; D002057:Burns, Chemical / Q000473:pathology / Q000628:therapy*; D003228:Conjunctiva / Q000473:pathology; D003315:Cornea / Q000473:pathology; D015237:Dinoprost / Q000032:analysis; D004224:Diterpenes; D005126:Eye Burns / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy*; D046934:Ginkgolides; D007783:Lactones / Q000008:administration & dosage*; D009883:Ophthalmic Solutions; D010936:Plant Extracts / Q000008:administration & dosage*; D011817:Rabbits; D011863:Radioimmunoassay; D014945:Wound Healing / Q000187:drug effects
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D009883:Ophthalmic Solutions; D010936:Plant Extracts; C058295:ginkgolide C; D015237:Dinoprost
Zur antiphlogistischen Wirksamkeit des Ginkgolids BN 52 021 bei der Verätzung des Kaninchenauges.