Glomerulopressin in end-stage renal disease. Effect of hemodialysis.
Plasma and hemofiltrate activities and hemodialysis (HD) clearance of glomerulopressin (GP) were measured in eight end-stage renal disease (ESRD) patients. Four normal volunteers served as controls. Plasma GP was elevated significantly in the ESRD group and fell with HD. Significant amounts of GP were found in the hemofiltrate. Single passage through the dialyzer resulted in a 24.7% fall in plasma GP activity. Dialyzer clearance of GP averaged 144 ml/min (75.4% of urea clearance). In conclusion, plasma GP was elevated in ESRD and readily removed by HD.
Zhou
X J
XJ
Department of Medicine, University of California, Irvine, Orange.
Vaziri
N D
ND
Kaupke
C J
CJ
D000328:Adult; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D005965:Glucuronates / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D007678:Kidney Glomerulus / Q000503:physiopathology; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D006435:Renal Dialysis
D005965:Glucuronates; C014007:glomerulopressin