title: [Silver nitrate burn after Credé's preventive treatment. A roentgen analytic and scanning electron microscopy study].
abstract: Following Credé's prophylaxis with silver-nitrate, the cornea of a newborn presented greyish-brown, lime-like plaques on the nasal part of the right eye. A paracentral ulcerating stromal opacification undermined these appositions, when the patient was admitted to the eye-clinic at Aachen. In the material taken in a lamellar keratectomy scanning electron microscopical examination was able to prove the existence of granules, previously described in light-microscopy. These granules measured 100 to 300 nm in diameter and were placed up to 110 microns deep into the corneal stroma of the specimen. An earlier chemical analysis of necrotic material showed no silver specific reaction. By means of EDX-Analysis these granules could be identified as silver-containing. This was once reassured by a newly developed modification of van-Kossa's-staining-method. The fact that the granular deposits contained mainly silver proves that the onset of a sodium-chloride-irrigation did not promote an intended therapeutic silver-chloride-precipitation and therefore had no effects on the silver-nitrate's penetration abilities. Injuries by silver-nitrate-solutions used for Credé's prophylaxis are seldom but still reported. The mechanism of injury in this case of a child, born by sectio remains unknown. Neither the use of an unusual silvernitrate solution, that was taken from a disposable ampoule (Mova-Nitrat) was reported, nor any corneal injury during sectio mentioned.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Augenklinik, RWTH Aachen.
authors.forename: G
authors.initials: G
authors.lastname: Schirner
authors.forename: N F
authors.initials: NF
authors.lastname: Schrage
authors.forename: S
authors.initials: S
authors.lastname: Salla
authors.forename: C
authors.initials: C
authors.lastname: Teping
authors.forename: M
authors.initials: M
authors.lastname: Reim
authors.forename: W G
authors.initials: WG
authors.lastname: Burchard
authors.forename: B
authors.initials: B
authors.lastname: Schwab
mesh_terms: D002057:Burns, Chemical / Q000473:pathology* / Q000601:surgery; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D004577:Electron Probe Microanalysis; D005126:Eye Burns / Q000139:chemically induced* / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008855:Microscopy, Electron, Scanning; D009883:Ophthalmic Solutions; D012835:Silver Nitrate / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D014945:Wound Healing / Q000502:physiology
chemical_list: D009883:Ophthalmic Solutions; D012835:Silver Nitrate
vernacular_title: Silbernitratverätzung nach Credéscher Prophylaxe. Eine röntgenanalytische und rasterelektronenmikroskopische Untersuchung.