[Stabilization of standard samples of levorin and nystatin with antioxidants].
To prolong the storage period of the reference samples of levorin and nystatin, polyenic macrolide antibiotics, their effect of 23 antioxidants was studied by using rapid inactivation. The antioxidants belonged to compounds of different classes. The inactivation was performed at 20, 37 and 50 degrees C in the presence of 1, 2 or 5 per cent of the antioxidants. An antioxidant of the class of partially hydrated oxyquinolines was shown to have the highest stabilizing action on levorin and nystatin. It may be recommended for stabilizing the levorin and nystatin reference samples.
Shenin
Iu D
IuD
Belakhov
V V
VV
Kontelova
T N
TN
Levina
A A
AA
Shchinova
N E
NE
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002174:Candicidin / Q000493:pharmacokinetics / Q000592:standards*; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods / Q000592:standards; D009761:Nystatin / Q000493:pharmacokinetics / Q000592:standards*; D015125:Oxyquinoline / Q000737:chemistry / Q000494:pharmacology*; D012015:Reference Standards; D013048:Specimen Handling / Q000379:methods / Q000592:standards*; D013678:Technology, Pharmaceutical / Q000592:standards*; D013696:Temperature; D013997:Time Factors
D000975:Antioxidants; D009761:Nystatin; D002174:Candicidin; D015125:Oxyquinoline
Stabilizatsiia standartnykh obraztsov levorina i nistatina antioksidantami.