title: Treatment of angina pectoris with isosorbide-5-mononitrate. A multicenter study in general practice.
abstract: In this multicenter study 191 practitioners treated 532 patients with coronary artery disease and chronic stable angina pectoris by isosorbide-5-mononitrate (IS-5-MN), 20 mg 2-3 times daily. At the end of this period the frequency of anginal attacks was reduced by 83% and nitroglycerin consumption by 85.7% (p less than 0.0001). 40.1% of the patients categorized this treatment as very good, 28.6% as excellent and 23% as good. Serious adverse effects were observed in 2% of the patients and 6.4% of the patients discontinued treatment during the study because of inefficacy, infarction, death, or adverse effects. At the end of the study 90.2% of the patients were still on IS-5-MN. In conclusion, IS-5-MN is an effective treatment for patients with chronic stable angina pectoris. It is well tolerated, with minimal side effects.
authors.affiliation: Intensive Care Unit, Hospital Carlos Durand, Argentina.
authors.forename: E J
authors.initials: EJ
authors.lastname: Beck
authors.forename: J E
authors.initials: JE
authors.lastname: Koch
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged
chemical_list: D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate