Effects of haloperidol on motor and cognitive functioning in aged mice.
The effects of haloperidol on motor and functioning and cognitive functioning were studied in young (3-5 months old) and aged (20-22 months old) male mice by examining haloperidol-induced catalepsy and haloperidol-induced decrements in performance on a radial arm maze. The aged mice were much more sensitive to these adverse effects of haloperidol than were the young mice. Studies of the distribution of radioactivity from [3H]haloperidol to the brain indicated that the differences in sensitivity to this drug were not due to pharmacokinetic differences. The results demonstrate that mice are suitable for studies of aging-induced changes in the behavioral effects of neuroleptic agents.
Hoskins
B
B
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216-4505.
Peeler
D F
DF
Lawson
K
K
Barnes
A M
AM
Ho
I K
IK
D000375:Aging / Q000502:physiology* / Q000523:psychology; D000818:Animals; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*
D006220:Haloperidol