Effect of cimetidine administration on the pharmacokinetics of pirmenol.
The potential for a drug-drug interaction between pirmenol, an extensively metabolized antiarrhythmic agent, and cimetidine, an inhibitor of hepatic drug-metabolizing enzymes, was evaluated in eight healthy adults. A single 150-mg oral dose of pirmenol was administered on study days 1 and 8 and oral cimetidine, 300-mg QID, was administered on study days 4 through 11. Plasma and urine samples were collected after each pirmenol dose for determination of pirmenol concentration. Mean pirmenol concentration-time curves and pharmacokinetic parameters, including elimination rate constant, were not significantly altered by concomitant administration of cimetidine.
Stringer
K A
KA
Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, Buffalo, New York.
Lebsack
M E
ME
Cetnarowski-Cropp
A B
AB
Goldfarb
A L
AL
Radulovic
L L
LL
Bockbrader
H N
HN
Chang
T
T
Sedman
A J
AJ
D000284:Administration, Oral; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D010880:Piperidines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D010880:Piperidines; D002927:Cimetidine; C024318:pirmenol