title: Metoclopramide does not decrease the incidence of nausea and vomiting after alfentanil for outpatient anaesthesia.
abstract: Sixty patients were studied in a randomized, double-blind manner to determine whether metoclopramide added to droperidol decreased further the incidence of emetic symptoms (nausea, retching, vomiting) in outpatients receiving alfentanil anaesthesia for nasal surgery. Group 1 (n = 30) received metoclopramide 0.15 mg.kg-1 and Group 2 (n = 30) received placebo. In addition, both groups received droperidol 0.02 mg.kg-1 immediately before anaesthesia which was supplemented by alfentanil 20 micrograms.kg-1 at induction followed by an infusion of 0.25-1 micrograms.kg-1.min-1. Emetic symptoms were assessed 0-3 hr, 3-6 hr and 6-24 hr after surgery. Both groups received similar doses of alfentanil (mean +/- SD; Group 1 4641 +/- 1894 micrograms, Group 2 4714 +/- 1640 micrograms). The percentage of patients who had either nausea or vomiting at 0-3, 3-6 or 6-24 hr was 23%, 14% and 13% in Group 1; and 20%, 17% and 10% in Group 2. The overall incidence for each group was 8/30 (27%). There was no difference in the incidence of emetic symptoms between the groups at any time interval or throughout the study. Metoclopramide did not improve upon the antiemesis of droperidol during alfentanil anaesthesia for outpatient nasal surgery.
authors.affiliation: Department of General Anesthesiology, Cleveland Clinic Foundation, Ohio 44195.
authors.forename: D G
authors.initials: DG
authors.lastname: Whalley
authors.forename: S
authors.initials: S
authors.lastname: AlHaddad
authors.forename: I
authors.initials: I
authors.lastname: Khalil
authors.forename: W
authors.initials: W
authors.lastname: Maurer
authors.forename: C
authors.initials: C
authors.lastname: Furgerson
mesh_terms: D000328:Adult; D015760:Alfentanil / Q000009:adverse effects; D000556:Ambulatory Surgical Procedures; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous / Q000009:adverse effects; D004311:Double-Blind Method; D004329:Droperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D007530:Isoflurane; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D009609:Nitrous Oxide; D009666:Nose / Q000601:surgery; D010919:Placebos; D014839:Vomiting / Q000517:prevention & control*
chemical_list: D004338:Drug Combinations; D010919:Placebos; D015760:Alfentanil; D007530:Isoflurane; D009609:Nitrous Oxide; D008787:Metoclopramide; D004329:Droperidol