Bacterial N-nitrosation and gastric carcinogenesis in humans.
It has been hypothesized that bacterially produced N-nitroso compounds cause the progression from chronic atrophic gastritis through intestinal metaplasia and dysplasia to gastric cancer. If this is true then various consequences follow. These consequences are discussed, together with the evidence for or against them. The conclusion is that there is much to support the hypothesis.
Hill
M J
MJ
PHLS-CAMR, Salisbury, Wiltshire, United Kingdom.
D018407:Bacterial Physiological Phenomena; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009602:Nitrosamines / Q000378:metabolism*; D009603:Nitroso Compounds / Q000378:metabolism*; D013270:Stomach / Q000382:microbiology; D013274:Stomach Neoplasms / Q000209:etiology*
D009602:Nitrosamines; D009603:Nitroso Compounds