Increased activity of superoxide dismutase in kindled brain and suppression of kindled seizure following intra-amygdaloid injection of superoxide dismutase in rats.
The possible role played by superoxide dismutase (SOD), a major defense system for counteracting the toxic effects of oxygen free radicals, in amygdaloid (AM) kindling was examined in rats. A significant increase of total SOD activity in the whole brain was observed 30 days after completion of AM kindling. Intra-AM injection of 3 ng of one of the 2 SOD enzymes present in mammalian brain, i.e. cytosolic SOD containing copper and zinc (CuZn-SOD) caused suppression of kindled seizure. These results suggest that SOD participates in the persistence of AM kindled seizure susceptibility and the initiation of kindled AM seizure.
Mori
N
N
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Wada
J A
JA
Watanabe
M
M
Kumashiro
H
H
D000679:Amygdala; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D003300:Copper / Q000378:metabolism; D007267:Injections; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D008345:Manganese / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism
D000927:Anticonvulsants; D008345:Manganese; D003300:Copper; D013482:Superoxide Dismutase; D015032:Zinc