title: Myocardial accumulation of monoclonal antimyosin Fab in hypertrophic cardiomyopathy and postpartum cardiomyopathy.
abstract: Indium-111-antimyosin Fab scan was performed in patients with hypertrophic and postpartum cardiomyopathies to assess whether or not myocardial damage can be delineated. In two patients with hypertrophic cardiomyopathy, intense and diffuse antimyosin uptake was observed, although there was no evidence of acute myocardial damage or wall motion abnormality. A patient with postpartum cardiomyopathy showed a dense and relatively localized accumulation in the left ventricular anterior wall in association with thallium perfusion and wall motion abnormalities. Thus, antimyosin scanning can delineate not only manifested but also subclinical myocardial damage in hypertrophic and postpartum cardiomyopathies which may not be detectable by other techniques.
authors.affiliation: Second Department of Internal Medicine and Department of Radiology, Sapporo Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakata
authors.forename: M
authors.initials: M
authors.lastname: Gotoh
authors.forename: S
authors.initials: S
authors.lastname: Yonekura
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Shimamoto
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
authors.forename: O
authors.initials: O
authors.lastname: Iimura
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000378:metabolism; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D009942:Organometallic Compounds; D011644:Puerperal Disorders / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging
chemical_list: D000911:Antibodies, Monoclonal; D009942:Organometallic Compounds; C058899:imciromab pentetate