title: The modulation of ferryl myoglobin formation and its oxidative effects on low density lipoproteins by nitric oxide.
abstract: This study has investigated the interactions between nitric oxide and haem protein radicals. The results demonstrate that nitric oxide interacts with activated ferryl myoglobin species with reduction to metmyoglobin, but the extent and duration of the reduction depends on the relative concentrations of nitric oxide and hydrogen peroxide. Ferryl myoglobin has a much greater relative potential for oxidising polyunsaturated fatty acid side chains in low density lipoproteins than in cell membranes. The peroxidative response can be modulated by nitric oxide: ferryl myoglobin-mediated peroxidation of LDL may be enhanced or suppressed by nitric oxide depending on the relative concentrations of NO and hydrogen peroxide.
authors.affiliation: Division of Biochemistry, United Medical School, Guy's Hospital, London.
authors.forename: G
authors.initials: G
authors.lastname: Dee
authors.forename: C
authors.initials: C
authors.lastname: Rice-Evans
authors.forename: S
authors.initials: S
authors.lastname: Obeyesekera
authors.forename: S
authors.initials: S
authors.lastname: Meraji
authors.forename: M
authors.initials: M
authors.lastname: Jacobs
authors.forename: K R
authors.initials: KR
authors.lastname: Bruckdorfer
mesh_terms: D004910:Erythrocyte Membrane / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007700:Kinetics; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008786:Metmyoglobin / Q000378:metabolism*; D009569:Nitric Oxide / Q000494:pharmacology*
chemical_list: D008077:Lipoproteins, LDL; C028048:ferrylmyoglobin; D008786:Metmyoglobin; D009569:Nitric Oxide; D006861:Hydrogen Peroxide