title: Overview of immunological studies on A-bomb survivors.
abstract: Among the peripheral blood lymphocytes, T-cells and B-cells significantly decreased in number with age. Radiation exposure resulted in further significant decrease of T-cell count (but not B cells) in the elderly. T-cell response to PHA and allo-antigens also decreased with dose in the elderly group. In contrast, NK cell number and function increased with age while a significant dose effect was not observed.
authors.affiliation: Radiation Effects Research Foundation, Hiroshima, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Akiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Kusunoki
authors.forename: S
authors.initials: S
authors.lastname: Kyoizumi
mesh_terms: D000375:Aging / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000528:radiation effects*; D007564:Japan; D009689:Nuclear Warfare; D013534:Survival