title: [Pathogenetic bases of the use alpha-tocopherol and emoxypin in acute hemorrhage].
abstract: The accumulation of lipid peroxidation (LP) products and decrease of alpha-tocopherol (TP) content were demonstrable in the heart, lungs, kidneys and liver after acute blood loss. Injection of TP acetate inhibited LP and raised the content of endogenous TP in the heart, lungs and liver. The antioxidant emoxypin increased the reduced oxygen tension in the liver and kidneys after blood loss. The drug prevented the reduction of the glucocorticoid type II receptor level and increased the content of the type III receptors in liver cytosol of hemorrhagic animals.
authors.forename: S B
authors.initials: SB
authors.lastname: Matveev
authors.forename: V V
authors.initials: VV
authors.lastname: Marchenko
authors.forename: P P
authors.initials: PP
authors.lastname: Golikov
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D006470:Hemorrhage / Q000188:drug therapy* / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014810:Vitamin E / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D010847:Picolines; D014810:Vitamin E; C009820:6-methyl-2-ethyl-3-hydroxypyridine
vernacular_title: Patogeneticheskoe obosnovanie primenenie alfa-tokoferola i émoksipina pri ostroĭ krovopotere.