[The stability of the alkylating derivatives of oligodeoxyribonucleotides containing a cholesterol or phenazine radical added to the 3'-termination during their interaction with Acholeplasma laidlawii PG-8].
Stability of alkylating derivatives of decathymidylates protected on the 3'-terminal by cholesterol and phenazine residues has been studied in the process of their interaction with cells of Acholeplasma laidlawii PG-8. It is shown that the studied reagents are not split by nucleases of A. laidlawii PG-8 for the time necessary for alkylation of mycoplasma biopolymers.
Panchenko
L P
LP
Egorov
O V
OV
Skripal'
I G
IG
Raĭt
A S
AS
Ivanova
E M
EM
Zarytova
V F
VF
Vlasov
V V
VV
D000128:Acholeplasma laidlawii / Q000187:drug effects* / Q000201:enzymology; D000477:Alkylating Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002784:Cholesterol / Q000493:pharmacokinetics / Q000494:pharmacology*; D003851:Deoxyribonucleases / Q000187:drug effects / Q000378:metabolism; D004355:Drug Stability; D009838:Oligodeoxyribonucleotides / Q000493:pharmacokinetics / Q000494:pharmacology*; D010619:Phenazines / Q000493:pharmacokinetics / Q000494:pharmacology*; D012260:Ribonucleases / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D013997:Time Factors
D000477:Alkylating Agents; D009838:Oligodeoxyribonucleotides; D010619:Phenazines; D002784:Cholesterol; D003851:Deoxyribonucleases; D012260:Ribonucleases
Issledovanie stabil'nosti alkiliruiushchikh proizvodnykh oligodezoksiribonukleotidov, soderzhashchikh prisoedinennyĭ k 3'-kontsu ostatok kholesterina ili fenaziniia, pri vzaimodeĭstvii ikh s kletkami Acholeplasma laidlawii PG-8.