Rhabdomyolysis after suicidal ingestion of an overdose of caffeine, acetaminophen and phenazone as a fixed-dose combination (Spalt N).
Rhabdomyolysis without renal failure was noted after suicidal ingestion of 29 tablets of Spalt N containing 7.25 g of acetaminophen, 7.25 g of phenazone and 1.45 g of caffeine by a 29 year-old weighing 73 kg. The maximum serum creatine kinase was 1920 U/L, serum myoglobins were 49 to 167 ng/mL. Acetaminophen, phenazone and caffeine were quantified and identified in serum by gas chromatography and gas chromatography/mass spectrometry. It is suggested that rhabdomyolysis might have been caused by caffeine.
Michaelis
H C
HC
Department of Pharmacology and Toxicology, University of Göttingen, Germany.
Sharifi
S
S
Schoel
G
G
D000082:Acetaminophen / Q000493:pharmacokinetics / Q000506:poisoning*; D000328:Adult; D000983:Antipyrine / Q000493:pharmacokinetics / Q000506:poisoning*; D002110:Caffeine / Q000493:pharmacokinetics / Q000506:poisoning*; D003402:Creatine Kinase / Q000097:blood; D004338:Drug Combinations; D062787:Drug Overdose / Q000150:complications; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000097:blood; D012206:Rhabdomyolysis / Q000139:chemically induced*; D013406:Suicide, Attempted; D013607:Tablets
D004338:Drug Combinations; D009211:Myoglobin; D013607:Tablets; D000082:Acetaminophen; D002110:Caffeine; D003402:Creatine Kinase; D000983:Antipyrine