title: [Progressive multifocal leukoencephalopathy as a cause of neurologic symptoms in Sharp syndrome].
abstract: Progressive multifocal leukencephalopathy (PML) is a very rare complication of immunosuppressive or cytostatic treatment of rheumatic diseases. We describe a patient with a mixed connective tissue disease (MCTD) existing for more than 15 years, who had polyarthritis, myositis, scleroderma-like symptoms, pulmonary involvement, and psychosis of undetermined origin. After a 12-year low-dose corticosteroid therapy and a 4-year azathioprin therapy a quickly progressive PML developed; symptoms included: difficulty in urinating, bladder, articulation, spastic hemiplegia, eye movement malfunction. The patient died after after a few months. PML is an important consideration in the differential diagnosis when a patient with MCTD develops neurologic symptoms.
authors.affiliation: Rheumaklinik Oberammergau.
authors.forename: F
authors.initials: F
authors.lastname: Schneider
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects*; D001921:Brain / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000188:drug therapy*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology; D009460:Neurologic Examination
chemical_list: D000305:Adrenal Cortex Hormones; D001379:Azathioprine
vernacular_title: Progressive multifokale Leukencephalopathie als Ursache neurologischer Symptomatik bei Sharp-Syndrom.