title: Does magnesium sulfate alter the maternal cardiovascular response to vasopressor agents in gravid ewes?
abstract: Magnesium sulfate (MgSO4) attenuates the maternal compensatory response to hemorrhage in gravid ewes, perhaps by decreasing the response to endogenous vasopressors. The purpose of this study was to determine whether MgSO4 alters the cardiovascular response of gravid ewes to vasopressor agents. Sixteen gravid ewes underwent a series of experiments consisting of administration of two exogenous and two endogenous vasopressors, each with and without a concurrent MgSO4 infusion. Dose-response curves were constructed for phenylephrine (an alpha 1-adrenergic agonist), ST-91 (an alpha 2-adrenergic agonist), angiotensin II, and arginine vasopressin (AVP). MgSO4 significantly attenuated the increase in maternal mean arterial pressure and systemic vascular resistance and the decrease in cardiac output during ST-91 infusion but not during phenylephrine, angiotensin II, or AVP infusions. MgSO4 significantly attenuated the increase in uterine vascular resistance during phenylephrine, ST-91, and angiotensin II infusions and the decrease in uterine blood flow during phenylephrine and angiotensin II infusions. MgSO4 also appeared to attenuate the decrease in uterine blood flow during ST-91 infusion (P = 0.067). The present study suggests that MgSO4 antagonizes the effects of alpha 1-adrenergic agonists, alpha 2-adrenergic agonists, and angiotensin II on the uterine vasculature, thus providing a level of protection for the fetus in situations of maternal stress.
authors.affiliation: Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics 52242.
authors.forename: S L
authors.initials: SL
authors.lastname: Sipes
authors.forename: D H
authors.initials: DH
authors.lastname: Chestnut
authors.forename: R D
authors.initials: RD
authors.lastname: Vincent
authors.forename: C P
authors.initials: CP
authors.lastname: Weiner
authors.forename: C S
authors.initials: CS
authors.lastname: Thompson
authors.forename: P
authors.initials: P
authors.lastname: Chatterjee
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006863:Hydrogen-Ion Concentration; D008278:Magnesium Sulfate / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology*; D011247:Pregnancy; D012039:Regional Blood Flow / Q000187:drug effects; D012756:Sheep; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D000804:Angiotensin II; D001127:Arginine Vasopressin; D010656:Phenylephrine; C011266:ST 91; D008278:Magnesium Sulfate; D003000:Clonidine