title: Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheep.
abstract: The thermal and mechanical analgesic profile of buprenorphine at a dose rate of 1.5 micrograms/kg i.v. was investigated in five sheep. This dose produced significant analgesia for 40 min against the thermal stimulus, but no mechanical antinociception. A higher dose rate of 12 micrograms/kg also failed to produce antinociception to a mechanical stimulus. In addition, the effect of the drug (6 micrograms/kg) on respiratory gas tensions was determined and no significant changes were observed.
authors.affiliation: Department of Veterinary Surgery, University of Bristol, UK.
authors.forename: A E
authors.initials: AE
authors.lastname: Waterman
authors.forename: A
authors.initials: A
authors.lastname: Livingston
authors.forename: A
authors.initials: A
authors.lastname: Amin
mesh_terms: D000698:Analgesia / Q000662:veterinary*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis; D002047:Buprenorphine / Q000008:administration & dosage / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous / Q000662:veterinary; D009619:Nociceptors / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D012119:Respiration / Q000187:drug effects*; D012684:Sensory Thresholds; D012756:Sheep / Q000502:physiology*
chemical_list: D001639:Bicarbonates; D002245:Carbon Dioxide; D002047:Buprenorphine; D010100:Oxygen