2,4-D toxicosis. I: A pilot study of 2,4-dichlorophenoxyacetic acid- and dicamba-induced myotonia in experimental dogs.
English Pointer dogs dosed po with encapsulated 2,4-dichlorophenoxyacetic acid (2,4-D) or 2-methoxy-3,6-dichlorobenzoic acid (dicamba) developed varying degrees of myotonia. Dogs given 175 or 220 mg of 2,4-D/kg body weight rapidly developed clinical and electromyographic (EMG) manifestations consistent with a diagnosis of myotonia or pseudomyotonia. Dogs given 2,4-D at 86.7, 43.7 or 8.8 mg/kg body weight developed subclinical manifestations of myotonia detectable only with an electromyograph. The administration of 2,4-D at 1.3 or 1.0 mg/kg body weight failed to produce detectable EMG changes. One dog given dicamba at 86.7 mg/kg body weight developed clinical and EMG manifestations of myotonia similar to those induced by the highest doses of 2,4-D.
Beasley
V R
VR
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Arnold
E K
EK
Lovell
R A
RA
Parker
A J
AJ
D015084:2,4-Dichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000506:poisoning*; D000284:Administration, Oral; D000818:Animals; D003996:Dicamba / Q000008:administration & dosage / Q000506:poisoning*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004576:Electromyography; D005260:Female; D008297:Male; D009222:Myotonia / Q000139:chemically induced*; D010865:Pilot Projects
D015084:2,4-Dichlorophenoxyacetic Acid; D003996:Dicamba