[Chronopharmacokinetics of dexamethasone in young subjects].
Dexamethasone chronopharmacokinetics was studied in six young subjects 20 to 30 years old. The randomized cross-over study consisted of evening (11.00 p.m.) or morning (08.00 a.m.) dose separated by a period of one week. After the evening administration of the drug, only Tmax (1.77 +/- 0.74 à 11.00 p.m. and 0.99 +/- 0.64 à 08.00 a.m.) and Cmax/Tmax were higher than those determined at 08.00 a.m. This difference might be related to a cyclic variation of the absorption phase of dexamethasone. Thus, in our study, the time of administration has only a weak effect on the pharmacokinetics of dexamethasone.
Lamiable
D
D
Laboratoire de Pharmacologie, CHRU Maison Blanche, Reims Cedex.
Vistelle
R
R
Fay
R
R
Millart
H
H
Caron
J
J
Choisy
H
H
D000328:Adult; D000367:Age Factors; D002909:Chronobiology Phenomena; D003907:Dexamethasone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male
D003907:Dexamethasone
Chronopharmacocinétique de la dexaméthasone chez le sujet jeune.