title: Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter.
abstract: We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a region upstream of the TATA box which is the promoter region of the gene. Several consensus sequences have been identified, including an SRE and AP-1 binding site whose relative positions are identical to those in the 5' upstream region of the c-fos gene. We have also shown that FosB and c-Fos can downregulate the activity of the fosB promoter to a similar extent. The fosB gene is located in the [A1-B1] region of mouse chromosome 7.
authors.affiliation: Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-74000.
authors.forename: P S
authors.initials: PS
authors.lastname: Lazo
authors.forename: K
authors.initials: K
authors.lastname: Dorfman
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: M G
authors.initials: MG
authors.lastname: Mattéi
authors.forename: R
authors.initials: R
authors.lastname: Bravo
mesh_terms: D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics / Q000378:metabolism; D015536:Down-Regulation / Q000235:genetics*; D005091:Exons / Q000235:genetics; D016762:Genes, fos / Q000235:genetics*; D007438:Introns / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D016760:Proto-Oncogene Proteins c-fos / Q000737:chemistry / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D011993:Recombinant Fusion Proteins; D015500:Chloramphenicol O-Acetyltransferase