Antifungal and antiviral activities of benanomicins and their analogues.
In vitro activities of benanomicins and their analogues against human immunodeficiency virus and fungi including Candida, Cryptococcus and Aspergillus, were examined. The free carboxyl group and at least one sugar moiety in the benanomicins were essential for their activities. Benanomicin A was most active and had low toxicity, and was selected as the best candidate for chemotherapy.
Kondo
S
S
Department of Hygiene, Gunma University School of Medicine, Japan.
Gomi
S
S
Ikeda
D
D
Hamada
M
M
Takeuchi
T
T
Iwai
H
H
Seki
J
J
Hoshino
H
H
D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use* / Q000633:toxicity; D000935:Antifungal Agents / Q000627:therapeutic use* / Q000633:toxicity; D000998:Antiviral Agents / Q000627:therapeutic use* / Q000633:toxicity; D001230:Aspergillus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D002460:Cell Line; D003454:Cryptococcus / Q000187:drug effects*; D006678:HIV / Q000187:drug effects*; D007928:Lethal Dose 50; D051379:Mice; D013329:Structure-Activity Relationship; D000095643:Pradimicins and Benanomicins
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D000998:Antiviral Agents; C056805:benanomicin A; D000095643:Pradimicins and Benanomicins