Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.
Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.
Durif
F
F
Clinique Neurologique, CHU Clermont Ferrand, France.
Jeanneau
E
E
Serre-Debeauvais
F
F
Deffond
D
D
Eschalier
A
A
Tournilhac
M
M
D000286:Administration, Sublingual; D000368:Aged; D001058:Apomorphine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*
D001058:Apomorphine