title: A genetic response to high altitude hypoxia: high hemoglobin-oxygen affinity in chicken (Gallus gallus) from the Peruvian Andes.
abstract: A population of chicken (Gallus gallus) from the Peruvian Andes (4,000 m) carrying a high hemoglobin-oxygen affinity has been identified. This property remained stable after over 1 year residence at sea level and was transmitted to the descendants born at sea level. Chicken were introduced in South America during the Spanish conquest and therefore their adaptation time to high altitude is less than 500 years. This finding shows that a genotypic change in hemoglobin function can occur in an extremely short evolutionary time and leads to some reflections on the high altitude adaptation of the mammals that migrated to South America during the great Plio-Pleistocene interchange.
authors.affiliation: Departamento de ciencias fisiologicas, Universidad Peruana Cayetano Heredia, Lima.
authors.forename: F L
authors.initials: FL
authors.lastname: Velarde
authors.forename: D
authors.initials: D
authors.lastname: Espinoza
authors.forename: C
authors.initials: C
authors.lastname: Monge
authors.forename: C
authors.initials: C
authors.lastname: de Muizon
mesh_terms: D000531:Altitude; D000818:Animals; D005075:Biological Evolution; D002645:Chickens / Q000235:genetics*; D005260:Female; D006454:Hemoglobins / Q000235:genetics* / Q000378:metabolism; D000860:Hypoxia / Q000235:genetics*; D010100:Oxygen / Q000097:blood; D010568:Peru
chemical_list: D006454:Hemoglobins; D010100:Oxygen