Effects of intraamygdaloid injection of taurine and valyltaurine on amygdaloid kindled seizure in rats.
Antiepileptic effects of intracerebral injections of taurine and valyltaurine were examined in amygdaloid kindled rats. The effects were assessed whether the animals can evoke generalized seizures by a 10 microA higher stimulation intensity than triggering thresholds. In all fully-kindled animals that have received intraamygdaloid injection of 500 nmol taurine, the kindled seizure was completely abolished. Such a significant seizure suppression (p less than 0.05) was observed 12-24 h after the taurine injection. Valyltaurine (500 nmol) also suppressed the seizure in 60% of animals tested, but the effect was not statistically significant. The results indicate that taurine may effectively suppress epileptic seizures when it acts directly at the stimulation site amygdala.
Uemura
S
S
Miyazaki Mental Saga Hospital, Kyoto, Japan.
Ienaga
K
K
Higashiura
K
K
Kimura
H
H
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D007267:Injections; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000494:pharmacology*
D004151:Dipeptides; D013654:Taurine