Polyene antibiotics in the membrane environment.
The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.
Shervani
Z
Z
Department of Biochemistry, University of Delhi, India.
Sarkar
A K
AK
Bachhawat
B K
BK
D000666:Amphotericin B / Q000008:administration & dosage / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry; D004337:Drug Carriers; D005372:Filipin / Q000008:administration & dosage / Q000737:chemistry; D008081:Liposomes; D008563:Membrane Lipids / Q000737:chemistry; D013261:Sterols / Q000737:chemistry; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D008081:Liposomes; D008563:Membrane Lipids; D013261:Sterols; D000666:Amphotericin B; D005372:Filipin