Lymphocyte and neutrophil dysfunction associated with hepatitis B virus and hepatitis non-A, non-B virus infection in the chimpanzee.
Chimpanzees were examined for the effect of viral hepatitis infections on specific and nonspecific immune response mechanisms. The data suggest that infection with either hepatitis B virus or hepatitis non-A, non-B virus may result in suppression of cellular immune response components. Mitogen-induced lymphocyte proliferation was lower in virus-infected chimpanzees than in naive animals. Neutrophils from virus infected animals exhibited decreased or altered chemiluminescence kinetics.
Lafrado
L J
LJ
Ohio State University, Center for Retrovirus Research, Columbus.
Javadian
M A
MA
Marr
J M
JM
Wright
K A
KA
Kelliher
J C
JC
Dezzutti
C S
CS
Cummins
L
L
Olsen
R G
RG
D000818:Animals; D002118:Calcium / Q000097:blood; D006509:Hepatitis B / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D006526:Hepatitis C / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D006524:Hepatitis, Viral, Animal / Q000097:blood / Q000276:immunology*; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008863:Microspheres; D009504:Neutrophils / Q000276:immunology; D002679:Pan troglodytes
D002118:Calcium