Visualization of ingested medications in the stomach by ultrasound.
The authors describe a potential application of ultrasound in detection of pills in the stomach, and report the first case of its use in a patient. Thirty pills were studied in vitro by ultrasound. All were clearly detected, with better imaging compared with plain radiography. Four pills with slow disintegration (sustained release or enteric coated) and two with fast disintegration (immediate release) were further studied by ultrasound, following their ingestion by human volunteers. All four pills with slow disintegration were clearly visualized in the stomach, while detection of the other two pills was inconsistent. A sustained-release phenytoin capsule was detected by ultrasound in the stomach of a patient 3 hours after its ingestion. Ultrasound is a potential diagnostic tool in detection of pills in the stomach following acute ingestion. Its use, however, seems to be limited to sustained-release or enteric-coated preparations.
Amitai
Y
Y
Department of Pharmacology, Rush-Presbyterian St Luke's Medical Center, Chicago, IL 60612.
Silver
B
B
Leikin
J B
JB
Frischer
H
H
D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D004364:Pharmaceutical Preparations; D011041:Poisoning / Q000000981:diagnostic imaging; D013270:Stomach / Q000000981:diagnostic imaging; D013406:Suicide, Attempted; D013608:Tablets, Enteric-Coated; D014463:Ultrasonography
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D013608:Tablets, Enteric-Coated