title: Trisomy 13: a preferentially male chromosome aberration interfering specifically with myeloid proliferation and differentiation? Report of a case and review of the literature.
abstract: A case of trisomy 13 is presented: a 73-year-old man with acute nonlymphocytic leukemia (ANLL), FAB borderline M1/M2, and peripheral leukocyte and platelet counts that were difficult to control with chemotherapy. A literature review shows that 35 cases of trisomy 13 are known at present. They are characterized by male predominance (76%), preferentially myeloid disorders (ANLL, myelodysplastic syndromes, chronic myeloid leukemia), leucocytosis, and relatively high platelet counts and hemoglobins. It is suggested that trisomy 13 is a specific nosologic entity with male predominance and characterized by interference with proliferation and differentiation in the myeloid differentiation series.
authors.affiliation: Danish Cancer Society, Department of Cytogenetics, Aarhus Amtssygehus.
authors.forename: B
authors.initials: B
authors.lastname: Pedersen
authors.forename: I M
authors.initials: IM
authors.lastname: Jensen
mesh_terms: D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D007938:Leukemia / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D012737:Sex Factors; D016019:Survival Analysis; D014314:Trisomy