Ambulatory blood pressure monitoring in elderly hypertensives treated with the new calcium antagonist, nilvadipine.
A newly developed calcium antagonist, nilvadipine, was administered to 7 hypertensive patients aged 75.6 y. Nilvadipine 4 mg b.d. decreased the average 24-h blood pressure significantly from 169/89 mmHg to 152/81 mmHg after 7 to 14 days without any change in the pulse rate. The circadian patterns of blood pressure and pulse rate were not affected by nilvadipine. Although the present study was a preliminary one done over a short period in a small number of patients, the results suggest that nilvadipine exerts an antihypertensive effect without altering the circadian pattern or the variability of blood pressure in elderly hypertensive patients.
Tsuchihashi
T
T
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Tsukashima
A
A
Matsumura
K
K
Abe
I
I
Tominaga
M
M
Nakao
Y
Y
Kobayashi
K
K
Fujishima
M
M
D000368:Aged; D000369:Aged, 80 and over; D000553:Ambulatory Care; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D002121:Calcium Channel Blockers; C035100:nilvadipine; D009543:Nifedipine