Chronic intoxication with acetaldehyde stimulates collagen biosynthesis in rat liver.
It was found that chronic intoxication of rats with acetaldehyde results in a distinct, progressive increase of 5(3)H-proline incorporation into collagen synthesized by liver. At the same time, biosynthesis of other proline-containing (noncollagenous) proteins does not change significantly. The effects are similar to those induced by chronic intoxication of rats with ethanol. Since acetaldehyde is an intermediary metabolite formed during ethanol oxidation in liver, it may be concluded that acetaldehyde is a factor responsible for alcohol-induced liver fibrosis.
Pawlicka
E
E
Department of Biochemistry, Medical Academy of Bialystok, Poland.
Bańkowski
E
E
Sobolewski
K
K
D000079:Acetaldehyde / Q000506:poisoning*; D000818:Animals; D002908:Chronic Disease; D003094:Collagen / Q000096:biosynthesis*; D006909:Hydroxyproline / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003094:Collagen; D000079:Acetaldehyde; D006909:Hydroxyproline