Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line.
Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.
Noguchi
S
S
Department of Urology, Yokohama City University, School of Medicine, Japan.
Kubota
Y
Y
Shuin
T
T
Ito
E
E
Inoue
H
H
Yoshioka
T
T
D002118:Calcium / Q000378:metabolism*; D002460:Cell Line; D003470:Culture Media; D004790:Enzyme Induction; D015870:Gene Expression / Q000187:drug effects; D016259:Genes, myc / Q000187:drug effects*; D006801:Humans; D007680:Kidney Neoplasms; D007700:Kinetics; D008081:Liposomes; D010716:Phosphatidylinositols / Q000494:pharmacology*; D011493:Protein Kinase C / Q000096:biosynthesis / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms
D003470:Culture Media; D008081:Liposomes; D010716:Phosphatidylinositols; D011493:Protein Kinase C; D002118:Calcium