[A theory on the role of immunologic factors in the pathogenesis of primary glaucoma].
Basing on the literature data and their own clinical, immunomorphologic, and immunochemical findings in glaucoma patients and normal subjects, the authors suggest a concept on the immune factor contribution to the pathogenesis of primary open-angle glaucoma. According to the scheme they suggest, of primary importance in the development of autoimmune reactions in glaucoma are the following factors: changed antigenic specificity of the drainage zone tissues, resultant from involution processes; impaired immune homeostasis, effects of various internal and environmental factors. The pathogenetic role of autoimmune reactions and immunity system regulatory mechanism disorders is explained.
Zakharova
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IA
Stukalov
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SE
D000974:Antibodies, Antinuclear / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D005902:Glaucoma, Open-Angle / Q000209:etiology* / Q000276:immunology; D006801:Humans; D012590:Sclera / Q000276:immunology*; D014129:Trabecular Meshwork / Q000276:immunology*
D000974:Antibodies, Antinuclear
Kontseptsiia uchastiia immunnykh faktorov v patogeneze pervichnoĭ glaukomy.