Molecular cytogenetic analysis of a medulloblastoma with isochromosome 17 and double minutes.
Cytogenetic analysis of a medulloblastoma revealed two abnormal cell lines of 48,XY, +8, +8, -14, +der(14)t(1;14)(q11;p11),i(17q) and 51,XY, +5, +6, +8, +8, -14 + 20, +der (14)t(1;14)(q11;p11),i(17q), + dmin. The finding of double minute chromosomes in some medulloblastomas has been associated with amplification of the c-myc or N-myc oncogenes. We were unable to detect gene amplification with these probes by Southern blot analysis.
Sawyer
J R
JR
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock.
Swanson
C M
CM
Roloson
G J
GJ
Longee
D C
DC
Boop
F A
FA
Chadduck
W M
WM
D015139:Blotting, Southern; D002528:Cerebellar Neoplasms / Q000473:pathology*; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D002886:Chromosomes, Human, Pair 17; D016259:Genes, myc; D006801:Humans; D007621:Karyotyping; D008297:Male; D008527:Medulloblastoma / Q000473:pathology*; D013997:Time Factors; D014407:Tumor Cells, Cultured