Porcine von Willebrand disease and atherosclerosis. Influence of polymorphism in apolipoprotein B100 genotype.
The relationship of apolipoprotein-B genotype (Lpb) to diet-induced hypercholesterolemia and atherosclerosis was studied in von Willebrand disease (vWD) and normal pigs. Von Willebrand and normal pigs developed comparable levels of hypercholesterolemia (respectively, 757.9 +/- 49.4 versus 772.8 +/- 47.9 mg/dl, P = 0.95). Pigs with Lpb1/5 and Lpb5/8 genotypes, however, developed significantly higher serum cholesterol levels than those with other Lpb genotypes (866.1 +/- 64.0 mg/dl, P = 0.0343). Coronary and aortic atherosclerosis, measured by computer-assisted automated image analyzer, were not significantly different between vWD and normal pigs. Pigs with an Lpb5 allele developed significantly more atherosclerosis than those with the Lpb3/8 or Lpb8/8 genotypes or the rare Lpb1 allele (r greater than or equal to 0.434, P less than or equal to 0.05). Polymorphism in apolipoprotein B100 genotype, then, significantly influenced the severity of diet-induced hypercholesterolemia and atherosclerotic plaque formation in vWD and normal swine without regard to the vWD genotype.
Nichols
T C
TC
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill 27514.
Bellinger
D A
DA
Davis
K E
KE
Koch
G G
GG
Reddick
R L
RL
Read
M S
MS
Rapacz
J
J
Hasler-Rapacz
J
J
Brinkhous
K M
KM
Griggs
T R
TR
D000818:Animals; D001018:Aortic Diseases / Q000235:genetics; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000235:genetics*; D001161:Arteriosclerosis / Q000097:blood / Q000235:genetics* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000235:genetics; D004036:Diet, Atherogenic; D005838:Genotype; D008297:Male; D011110:Polymorphism, Genetic; D013552:Swine; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications* / Q000235:genetics*
D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D002784:Cholesterol