[Mammalian cellular phospholipases A2 and their physiological roles].
Phospholipase A2 hydrolyzes the ester linkage at sn-2 of glycerophospholipids and is thought to function as a key enzyme in generation of variety of bioactive mediators, such as prostaglandins and platelet-activating factor. In the present review, recent studies on two kinds of cellular phospholipases A2, 14 kDa group II phospholipase A2 and arachidonate-preferentially hydrolyzing phospholipase A2, will be summarized.
Kudo
I
I
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D006801:Humans; D006868:Hydrolysis; D008969:Molecular Sequence Data; D010712:Phosphatidic Acids / Q000378:metabolism; D010741:Phospholipases A / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D054467:Phospholipases A2; D011453:Prostaglandins / Q000096:biosynthesis
D010712:Phosphatidic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D010741:Phospholipases A; D054467:Phospholipases A2