title: Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
abstract: The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substantially greater than that observed previously with conventional liposomes and is associated with a more than 5-fold prolongation of liposome circulation time in blood, a marked decrease in uptake by tissues such as liver and spleen, and a corresponding increased accumulation in implanted tumors. These and other properties described here have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.
authors.affiliation: Department of Pharmacology, University of California, San Francisco 94143.
authors.forename: D
authors.initials: D
authors.lastname: Papahadjopoulos
authors.forename: T M
authors.initials: TM
authors.lastname: Allen
authors.forename: A
authors.initials: A
authors.lastname: Gabizon
authors.forename: E
authors.initials: E
authors.lastname: Mayhew
authors.forename: K
authors.initials: K
authors.lastname: Matthay
authors.forename: S K
authors.initials: SK
authors.lastname: Huang
authors.forename: K D
authors.initials: KD
authors.lastname: Lee
authors.forename: M C
authors.initials: MC
authors.lastname: Woodle
authors.forename: D D
authors.initials: DD
authors.lastname: Lasic
authors.forename: C
authors.initials: C
authors.lastname: Redemann
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004337:Drug Carriers; D004355:Drug Stability; D015251:Epirubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D008081:Liposomes / Q000493:pharmacokinetics; D008223:Lymphoma / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D005710:Gallium Radioisotopes; D008081:Liposomes; D015251:Epirubicin; D004317:Doxorubicin