Nucleolar organizer regions argyrophilic associated proteins in cutaneous melanocytic lesions.
We applied a simple silver staining technique to visualize nucleolar organizer regions associated proteins (AgNORs) for the study of 47 melanocytic lesions (20 malignant melanomas, 5 dysplastic nevi, 4 Spitz nevi, 2 Reed and Gartman's fusiform nevi and 16 melanocytic nevi). A statistically significant difference existed between the numbers of AgNORs per cell in benign and malignant lesions as a group. However, some overlapping counts were found, limiting the usefulness of the technique in differentiating benign from malignant lesions in individual cases.
Reis
J P
JP
Department of Dermatology, University Hospital, Coimbra, Portugal.
Tellechea
O
O
Baptista
A P
AP
D034961:Antigens, Nuclear; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D009506:Nevus / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D009687:Nuclear Proteins / Q000737:chemistry*; D012680:Sensitivity and Specificity; D016622:Silver Staining / Q000379:methods / Q000592:standards*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*
D034961:Antigens, Nuclear; D009687:Nuclear Proteins; C051963:nucleolar organizer region associated proteins