An effective enzyme interacting with poly (dT-dA).poly (dT-dA): a dynamic enhancer-repressor action.
The Green function technique is used to study the open hydrogen bond probability of poly(dT-dA).poly(dT-dA) when an effective enzyme is attached to the helix. The DNA interstrand hydrogen bond mean motion and probability of fluctuating to an open state depends on the internal vibrational frequency of the enzyme. An enzyme with internal frequency of 80 cm-1 reduces hydrogen bond motion and the resulting probability of hydrogen bond fluctuational opening. An enzyme with internal frequency of 72 cm-1 increases hydrogen bond motion and the probability of hydrogen bond breaking.
Beger
R
R
Department of Physics, Purdue University, West Lafayette, IN 47907.
Prohofsky
E W
EW
D001483:Base Sequence; D004247:DNA / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D004798:Enzymes / Q000378:metabolism*; D006860:Hydrogen Bonding; D008969:Molecular Sequence Data; D011067:Poly dA-dT / Q000737:chemistry / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*
D004798:Enzymes; D012097:Repressor Proteins; D011067:Poly dA-dT; D004247:DNA