HLA-associated susceptibility to HIV-1 infection.
We studied HLA antigen distribution of 50 heterosexual partners of HIV+ drug abusers with more than 1 year of sexual exposure to HIV, 36 children born to seropositive mothers and 61 haemophiliac patients exposed to presumably infectious clotting factor concentrates. B52 and B44 antigens were associated with HIV resistance while B51 was associated with HIV susceptibility. Forty-nine HIV+ drug abusers, spouses of heterosexual partners studied and 25 HIV+ mothers of the children were also typed. DR11 phenotype was associated with infectiousness of HIV+ subjects. Our data suggest that the HLA region controls susceptibility to infection with HIV and infectiousness of HIV+ subjects in different risk groups.
Fabio
G
G
Institute of Internal Medicine, Infectious Diseases and Immunopathology, University of Milan, Italy.
Scorza
R
R
Lazzarin
A
A
Marchini
M
M
Zarantonello
M
M
D'Arminio
A
A
Marchisio
P
P
Plebani
A
A
Luzzati
R
R
Costigliola
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D015497:HIV-1; D015234:HLA-A Antigens / Q000032:analysis*; D015235:HLA-B Antigens / Q000032:analysis*; D006684:HLA-DR Antigens / Q000032:analysis*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens