Biochemical abnormalities in developing E1 mouse.
Complex biochemical abnormalities were found in the early developmental stage of the E1 mouse. First, the E1 mouse has abnormal levels of specific amino acid concentration within a week from birth. Second, an unusual expression of poly(A)+ RNA from the one-day newborn liver of the E1 mouse was detected by use of Cot 100 DNA as a probe. Third, sodium channels are increased in synaptosomes and at the mRNA expression level of the 3 or 4-week-old E1 mouse brains, compared with the ddY mouse. These results suggest that the biochemical abnormalities described in this study may affect greatly the epileptogenesis of E1 mouse.
Sashihara
S
S
Department of Molecular Biology, University of Occupational Environmental Health School of Medicine, Kitakyushu, Japan.
Aramaki
I
I
Murai
Y
Y
Mita
T
T
D000367:Age Factors; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000503:physiopathology; D015342:DNA Probes; D017029:Epilepsy, Complex Partial / Q000235:genetics / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology; D051379:Mice; D008818:Mice, Neurologic Mutants; D012640:Seizures / Q000235:genetics / Q000503:physiopathology*
D000596:Amino Acids; D015342:DNA Probes