[The bioavailability of paracetamol II. The effect of porosity and mechanical properties of the dosage form on solubility].
The authors attempt to explain differences observed in dissolution rate of twelve different brands of paracetamol (nine tablets and three capsules) in terms of pore structure and tensile strength; the pore structure of both tablets and capsules is investigated by mercury porosimetry. Brands (tablets) which liberate paracetamol rapidly are characterized by a higher porosity value. Higher mean pore diameter signifies less t50 and higher porosity. An increase in tensile strength results in an increase in t50 and a decrease in porosity. Porosity alone cannot dictate the dissolution behaviour of capsules.
Abebe
A
A
Laboratoire de Pharmacie Galénique et Industrielle, Université Joseph Fourier, Meylan.
Chulia
D
D
Verain
A
A
D000082:Acetaminophen / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D013607:Tablets
D002214:Capsules; D013607:Tablets; D000082:Acetaminophen
Lyodisponibilité du paracétamol. II. Influence de la porosité et des propriétés mécaniques de la forme galénique sur la dissolution.