title: Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.
abstract: Recent studies have identified genes within the major histocompatibility complex (MHC) that may play a role in presentation of antigenic peptides to T cells. We have previously described RING4, a gene within the human MHC class II region that has sequence homology with members of the ABC ("ATP-binding cassette") transporter superfamily. We now report the nucleotide sequence of RING11, a second ABC transporter gene located approximately 7 kilobases telomeric to RING4, RING11 is gamma-interferon inducible, a property shared with other genes involved in antigen presentation. Comparison between the amino acid sequences of RING11 and RING4 reveals strong homology. We propose that they form a heterodimer that transports peptides from the cytoplasm into the endoplasmic reticulum. We have identified two RING11 alleles, which differ in the length of their derived protein sequence by 17 amino acids. The more common of these alleles is present in a Caucasoid population at a frequency of 79%.
authors.affiliation: Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, United Kingdom.
authors.forename: S H
authors.initials: SH
authors.lastname: Powis
authors.forename: I
authors.initials: I
authors.lastname: Mockridge
authors.forename: A
authors.initials: A
authors.lastname: Kelly
authors.forename: L A
authors.initials: LA
authors.lastname: Kerr
authors.forename: R
authors.initials: R
authors.lastname: Glynne
authors.forename: U
authors.initials: U
authors.lastname: Gileadi
authors.forename: S
authors.initials: S
authors.lastname: Beck
authors.forename: J
authors.initials: J
authors.lastname: Trowsdale
mesh_terms: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D000255:Adenosine Triphosphate / Q000378:metabolism; D000595:Amino Acid Sequence; D000938:Antigen-Presenting Cells / Q000502:physiology*; D001483:Base Sequence; D001692:Biological Transport; D002352:Carrier Proteins; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D015870:Gene Expression / Q000187:drug effects; D005796:Genes; D007371:Interferon-gamma / Q000494:pharmacology; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D008565:Membrane Proteins; D009838:Oligodeoxyribonucleotides; D012333:RNA, Messenger; C071692:TAP2 protein, human; D007371:Interferon-gamma; D000255:Adenosine Triphosphate; D004247:DNA