title: Omeprazole vs. ranitidine in short-term treatment of Helicobacter pylori positive duodenal ulcer patients.
abstract: Forty-three patients with active duodenal ulcer and Helicobacter pylori positivity in gastric antrum were randomly assigned to either omeprazole treatment (20 mg once a day) or ranitidine treatment (300 mg once a day) for 28 days. Re-evaluation of the patients (clinical and endoscopic examination and assessments for H pylori detection) was repeated after 2 weeks and at the end of the treatment. Healing rates in the omeprazole group were 40% after 2 weeks and 90% after 4 weeks, in the ranitidine group ulcer healing was recorded in 20% of patients after 2 weeks and in 80% after 4 weeks. Differences between treatments at 2 and 4 weeks were not statistically significant. Clinical response (disappearance of ulcer-related symptoms) was better in the omeprazole group at 2 weeks (p less than 0.05) but not at 4 weeks. At the end of the trial H pylori positivity in gastric antrum disappeared in 95% of the patients treated with omeprazole and in 5% of the patients who received ranitidine (p less than 0.001). The results confirm the effectiveness of omeprazole in short-term treatment of duodenal ulcer and re-emphasize the powerful activity of the drug on H pylori infection.
authors.affiliation: Istituto di I Patologia Medica dell'Università di Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Catalano
authors.forename: A
authors.initials: A
authors.lastname: Mangiameli
authors.forename: G
authors.initials: G
authors.lastname: Inserra
authors.forename: S
authors.initials: S
authors.lastname: Monello
authors.forename: A
authors.initials: A
authors.lastname: Brogna
authors.forename: M
authors.initials: M
authors.lastname: Sofia
authors.forename: G
authors.initials: G
authors.lastname: Rizzo
authors.forename: M
authors.initials: M
authors.lastname: Ayoubi Khajekini
authors.forename: A
authors.initials: A
authors.lastname: Blasi
mesh_terms: D000328:Adult; D000368:Aged; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D004724:Endoscopy; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D011706:Pyloric Antrum / Q000382:microbiology; D011897:Random Allocation; D011899:Ranitidine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011899:Ranitidine; D009853:Omeprazole