Translocation (Y;2) in childhood acute lymphoblastic leukemia.
A case of ALL in a 2 1/2-year-old boy with fatal outcome is presented. Cytogenetic analysis revealed a hypodiploid karyotype: 45,X-Y,-2,+der (2)t(Y;2),-12,i(17q),+mar. Some metaphases represented a sideline with 44 chromosomes and monosomy 8 was a consistent anomaly. These findings are rather uncommon in ALL. Hypodiploidy and the translocation, however, indicated poor prognosis in this case.
Kowalczyk
J R
JR
Institute of Pediatrics, Lublin, Poland.
Chobotow
M
M
Sladkowska
G
G
D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D002871:Chromosome Banding; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D007621:Karyotyping; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic; D014998:Y Chromosome