title: Tissue-type plasminogen activator of colonic mucosa in ulcerative colitis. Evidence of endothelium-derived fibrinolytic activation.
abstract: Microvascular endothelial alterations are thought to be a crucial step for development of hemorrhagic changes in various pathological states. In this study, we determined the activity and amount of tissue-type plasminogen activator (t-PA) in the biopsy specimens from sigmoid colon of patients with ulcerative colitis to evaluate endothelial alterations and vascular changes of permeability. The results of this investigation revealed that mucosal amount of t-PA in the active stage of ulcerative colitis was two- to threefold higher than in healthy controls, while t-PA levels in plasma samples showed no remarkable differences among the groups. Increased t-PA activity appeared to correlate well to the degree of inflammation of colonic mucosa, and t-PA amount was still increased in the inactive stage. The present study indicates that t-PA determination in colonic biopsy specimens may be useful for the evaluation of clinical activity of ulcerative colitis in terms of the mucosal microvascular endothelial changes.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Kurose
authors.forename: S
authors.initials: S
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Suematsu
authors.forename: H
authors.initials: H
authors.lastname: Serizawa
authors.forename: D
authors.initials: D
authors.lastname: Fukumura
authors.forename: H
authors.initials: H
authors.lastname: Asako
authors.forename: T
authors.initials: T
authors.lastname: Hibi
authors.forename: M
authors.initials: M
authors.lastname: Tsuchiya
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D012809:Colon, Sigmoid / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged; D010959:Tissue Plasminogen Activator / Q000032:analysis* / Q000097:blood
chemical_list: D010959:Tissue Plasminogen Activator