Blockade of 5-HT2 receptors protects against impairment of working memory following transient forebrain ischemia in the rat.
The effects of the 5-HT2 receptor antagonists pirenperone, cinanserin and ritanserin on impairment of working memory in an animal model of cerebral ischemia were investigated, using a three-panel runway task. A 5-min period of ischemia caused a significant increase in the number of errors (attempts to pass through two incorrect panels of the 3 panel gates at 4 choice points). Pirenperone at 0.32 and 1.0 mg/kg, cinanserin 10 mg/kg and ritanserin 3.2 mg/kg administered i.p. immediately after blood flow reperfusion significantly reduced the increase in errors expected to occur 24 h after the 5 min of ischemia. These results suggest that the blockade of 5-HT2 receptors prevents the impairment of working memory following transient forebrain ischemia.
Ohno
M
M
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yamamoto
T
T
Watanabe
S
S
D000818:Animals; D002928:Cinanserin / Q000494:pharmacology; D002546:Ischemic Attack, Transient / Q000523:psychology*; D008297:Male; D008568:Memory / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists
D010880:Piperidines; D012702:Serotonin Antagonists; D016713:Ritanserin; D002928:Cinanserin; C034177:pirenperone