[Linear IgA dermatosis in childhood].
In a six-year-old girl with linear IgA dermatosis of childhood there were lesions with typical rosette like configuration, crusted erosions and isolated bullae on apparently normal skin. The histopathology revealed subepidermal blister and superficial perivascular lymphohistiocytic infiltrate with many neurophils and some eosinophils. Direct immunofluorescence examination showed linear deposits of IgA along the basal membrane zone. Circulating antibodies were absent. Therapy with dapsone in a dose of 25 mg/day was effective.
Megahed
M
M
Hautklinik Heinrich-Heine-Universität, Düsseldorf.
Goerz
G
G
Lenard
H G
HG
Plewig
G
G
D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D002648:Child; D003622:Dapsone / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D012867:Skin / Q000276:immunology / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D007070:Immunoglobulin A; D003622:Dapsone
Lineare IgA-Dermatose des Kindesalters.