Multicentre study on antibiotic susceptibilities of anaerobic bacteria to cefoperazone-sulbactam and other antimicrobial agents.
The antibiotic susceptibilities of 241 anaerobic bacteria recovered from six geographic sites in North America were tested by agar dilution to cefoperazone-sulbactam and other drugs. Of the 189 Bacteroides fragilis group isolates, only one was resistant to cefoperazone-sulbactam (0.5%) or ampicillin-sulbactam (0.5%), and none was resistant to ticarcillin-clavulanate or chloramphenicol. No resistance to cefoperazone-sulbactam was observed among the other Bacteroides spp., Clostridium spp., or Peptostreptococcus spp. Resistance to cefoperazone-sulbactam is not commonly observed against anaerobic bacteria recovered from different geographical sites across North America.
Clark
R B
RB
Department of Pathology, Crozer-Chester Medical Center, Upland, PA 19013.
Bartelt
M A
MA
Chan
E L
EL
Dalton
H P
HP
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D002438:Cefoperazone / Q000494:pharmacology*; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D013407:Sulbactam / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D002438:Cefoperazone; D013407:Sulbactam