title: Abolition of photoparoxysmal response in progressive myoclonus epilepsy.
abstract: We have investigated the effect of piracetam on photoparoxysmal responses in 3 patients with progressive myoclonus epilepsy. With doses of up to 10 g/day, elimination of photoparoxysmal responses was achieved in all 3 patients. Corresponding to EEG improvement, the clinical performance improved slightly in 2 patients and definitely in 1 patient when piracetam was added to their medication of valproate and clonazepam. According to our data, medical treatment of myoclonus with piracetam is justified particularly in myoclonus of cortical origin.
authors.affiliation: Neurologische Universitätsklinik München, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Paulus
authors.forename: S
authors.initials: S
authors.lastname: Ried
authors.forename: S R
authors.initials: SR
authors.lastname: Stodieck
authors.forename: D
authors.initials: D
authors.lastname: Schmidt
mesh_terms: D000293:Adolescent; D002998:Clonazepam / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects*; D004576:Electromyography / Q000187:drug effects*; D004831:Epilepsies, Myoclonic / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D010889:Piracetam / Q000627:therapeutic use*; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D002998:Clonazepam; D014635:Valproic Acid; D010889:Piracetam