title: Comparison of the body wall myosin heavy chain sequences from Onchocerca volvulus and Brugia malayi.
abstract: The complete coding sequence of Onchocerca volvulus myosin heavy chain has been determined from a series of overlapping cDNAs. The protein sequences from the 2 filarids, one responsible for subcutaneous filariasis, the other for lymphatic filariasis, show 92% identity, and are 1957 amino acids long. Each protein sequence is also equally related, with 75% identity, to MHC-B, the protein encoded by the unc-54 gene of the free-living nematode C.elegans. Such analysis is useful in phylogenetic studies among nematodes, as well as in structure-function relationships among myosin isolates.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY.
authors.forename: C
authors.initials: C
authors.lastname: Werner
authors.forename: T V
authors.initials: TV
authors.lastname: Rajan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002009:Brugia / Q000235:genetics*; D002107:Caenorhabditis; D004247:DNA / Q000235:genetics; D015723:Gene Library; D008969:Molecular Sequence Data; D009218:Myosins / Q000235:genetics*; D009854:Onchocerca / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid
chemical_list: D004247:DNA; D009218:Myosins