title: Could proteolytic enzyme modulate the interaction platelets/vessel wall in presence of ASA at ultra low doses?
abstract: Acetylsalicylic acid (ASA) is known to act on platelets and vessel walls. At ultra low doses it reverses the inhibitory effects produced by a vascular fragment. Use of papain on normal platelets in vitro led to the appearance of platelet aggregation without collagen induction with a range of 20.25 +/- 28.91%. In the presence of vascular fragments (without ASA), this "spontaneous" aggregation remained but was reduced (13.26 +/- 27.73%). This effect was reversed by ASA treatment (29.41 +/- 24.17%). Reversion of vascular inhibition by ASA was not modified by papain.
authors.affiliation: CJF Inserm 88/13, Laboratoire d'Hématologie, Bordeaux, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Lalanne
authors.forename: O
authors.initials: O
authors.lastname: de Seze
authors.forename: C
authors.initials: C
authors.lastname: Doutremepuich
authors.forename: P
authors.initials: P
authors.lastname: Belon
mesh_terms: D001241:Aspirin / Q000008:administration & dosage* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D001808:Blood Vessels / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D010206:Papain / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects; D012996:Solutions
chemical_list: D012996:Solutions; D010206:Papain; D001241:Aspirin