title: Diagnosis of neuronal colonic dysplasia in primary chronic constipation and sigmoid diverticulosis endoscopic biopsy and enzyme-histochemical examination.
abstract: Neuronal colonic dysplasia is a separate clinical entity belonging to the group of congenital defects of intestinal innervation. Its enzyme-histochemical diagnosis is possible by endoscopic biopsy examination of the rectosigmoid. Enzyme-histochemically, it is characterized by dysplasia of the submucous plexus secondary to developmental defects. The principal clinical feature is weak propulsive motility. A clinical study was carried out to investigate the role of neuronal colonic dysplasia in the aetiology and pathogenesis of primary chronic constipation and diverticulosis of the sigmoid colon in adults.
authors.affiliation: Chirurgische Abteilung, Krankenhaus Dornbirn, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Stoss
authors.forename: W
authors.initials: W
authors.lastname: Meier-Ruge
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000368:Aged; D001341:Autonomic Nervous System / Q000473:pathology; D001706:Biopsy; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D003106:Colon / Q000201:enzymology / Q000294:innervation / Q000473:pathology*; D003967:Diarrhea / Q000150:complications*; D004241:Diverticulum, Colon / Q000150:complications*; D005260:Female; D006627:Hirschsprung Disease / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D011351:Proctoscopy
chemical_list: D000110:Acetylcholinesterase