Intrauterine fertilization capsules--a clinical trial.
Treatment of 26 women with tubal infertility was attempted using intrauterine capsules loaded with oocytes and spermatozoa. The stimulation protocol was as used for in vitro fertilization and embryo transfer and consisted of short-term use of Buserelin, human menopausal gonadotropin, and human chorionic gonadotropin. Oocytes were collected by ultrasonically guided transvaginal aspiration, and spermatozoa were prepared by swim-up technique. The gametes were placed in agar capsules 4 hr after oocyte collection, and the capsules were introduced to the uterine fundus using an insertion tube and piston from an intrauterine device. Six complete capsules and parts of two other capsules were expelled. None of the women became pregnant, compared with a pregnancy rate of 21% per aspiration following in vitro fertilization and embryo transfer during the same period.
Lenz
S
S
Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen, Denmark.
Lindenberg
S
S
Sundberg
K
K
Andersen
A N
AN
Horness
P
P
Starup
J
J
Andersen
C Y
CY
Jensen
S S
SS
Hay-Schmidt
A
A
D002064:Buserelin / Q000627:therapeutic use; D002214:Capsules / Q000008:administration & dosage* / Q000592:standards*; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects / Q000379:methods*; D006801:Humans; D007267:Injections; D007434:Intrauterine Devices; D008297:Male; D008596:Menotropins / Q000627:therapeutic use; D009865:Oocytes / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects / Q000502:physiology; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging
D002214:Capsules; D006063:Chorionic Gonadotropin; D008596:Menotropins; D002064:Buserelin