[The effect of low doses of external gamma irradiation on the chromatin structure and activity of the histone-specific proteinases of rat brain cells].
Irradiation of rats with doses of 0.5 to 2 Gy was shown to cause dose-dependent changes in the sensitivity of brain cell chromatin to the effect of DNAase I that were manifested by the increased level of DNA hydrolysis and a high content of the chromatin soluble fractions. The chromatin structure was only partially restored 24 h after irradiation. Changes in the chromatin structure were accompanied by the increase in the histone-specific proteinase activity.
Protas
A F
AF
Chaialo
P P
PP
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology / Q000528:radiation effects* / Q000648:ultrastructure; D002843:Chromatin / Q000187:drug effects / Q000528:radiation effects* / Q000648:ultrastructure; D004247:DNA / Q000032:analysis / Q000187:drug effects / Q000528:radiation effects; D003850:Deoxyribonuclease I / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D010450:Endopeptidases / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D002843:Chromatin; D004247:DNA; D003850:Deoxyribonuclease I; D010450:Endopeptidases; C021361:histone proteases
Vliianie nizkikh doz vneshnego gamma-oblucheniia na strukturu khromatina na aktivnost' gistonspetsificheskikh proteinaz kletok golovnogo mozga krys.