title: Transient forebrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil.
abstract: We examined the effect of transient forebrain ischemia of 2-, 3-, 4- and 5-min duration on the development of delayed neuronal death in field CA1 of the hippocampus in the gerbil whose brain temperature was maintained at 37 degrees C. Transient ischemia of 3- and 4-min duration caused almost the same maximal damage in field CA1 as observed in the gerbils subjected to 5-min ischemia. A detrimental factor inducing delayed neuronal death in field CA1 may be already set up during the first 3 min after the onset of ischemia in the gerbil whose brain temperature is maintained at normothermic levels.
authors.affiliation: Department of Physiology, School of Medicine, Ehime University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Mitani
authors.forename: Y
authors.initials: Y
authors.lastname: Andou
authors.forename: S
authors.initials: S
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D000818:Animals; D016923:Cell Death / Q000502:physiology; D005849:Gerbillinae; D006624:Hippocampus / Q000166:cytology / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D009410:Nerve Degeneration / Q000502:physiology; D009474:Neurons / Q000502:physiology*