A new treatment strategy using both intermittent short dialysis and continuous ambulatory hemofiltration.
The authors devised a new treatment strategy using continuous ambulatory hemofiltration (CAHF) in between short hemodialyses (short HD). For CAHF, a small wearable hemofilter (0.1 m2) was developed using a membrane permeable to low molecular weight proteins. During short HD, no body water was removed, but saline, equivalent to 3% body weight, was administered at a constant rate. During CAHF, 1 L of replacement fluid was administered intravenously after every meal to increase the replacement volume. Switch from the conventional to new strategy resulted in far more stable blood pressure during short HD, a decrease in time averaged body weight, and a decrease in a decrease in time averaged blood urea nitrogen and plasma beta 2-m levels.
Takai
I
I
Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan.
Shinzato
T
T
Morita
H
H
Fujita
Y
Y
Inoue
I
I
Kobayakawa
H
H
Maeda
K
K
D000553:Ambulatory Care; D001835:Body Weight / Q000502:physiology; D003131:Combined Modality Therapy; D005260:Female; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D014511:Uremia / Q000628:therapy*; D014882:Water-Electrolyte Balance / Q000502:physiology