Intravenous nitrogen mustard given immediately after mastectomy: possible effect on local recurrence.
A small group of patients with Stage I and II ductal breast carcinomas were treated with intravenous nitrogen mustard the day of mastectomy and the first two postoperative days. Long term follow-up revealed that only one patient developed isolated local recurrence, a rate much lower than usually reported. It is possible that early use of chemotherapy could reduce local recurrences in the recently traumatized tissue.
Hines
J R
JR
Department of Surgery, Northwestern University Medical School, Chicago, Illinois 60611.
D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008408:Mastectomy / Q000009:adverse effects*; D008466:Mechlorethamine / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011182:Postoperative Care
D008466:Mechlorethamine