title: Efficacy of triclabendazole against natural infections of Fascioloides magna in wapiti.
abstract: Fourteen free-ranging adult wapiti (Cervus elaphus nelsoni) were captured in Banff National Park, Alberta (Canada) and held in captivity near Edmonton. A 24% suspension of triclabendazole at doses of 30 to 100 mg/kg body weight was drenched into the rumen of eight females and four males. Two male wapiti were used as untreated controls. Animals were killed and examined at 4 (n = 3), 6 (n = 4), or 8 (n = 4) wk after treatment. Efficacy was 90% against immature Fascioloides magna collected 4 wk after treatment and 98% against adult flukes collected 4, 6 or 8 wk after treatment. All 32 flukes recovered from control wapiti were active and apparently healthy. Treatment at 50 to 60 mg/kg is recommended against F. magna in wapiti. A protocol for treating infected wapiti is outlined.
authors.affiliation: Alberta Fish and Wildlife Division, Edmonton, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Pybus
authors.forename: D K
authors.initials: DK
authors.lastname: Onderka
authors.forename: N
authors.initials: N
authors.lastname: Cool
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D003670:Deer / Q000469:parasitology*; D005212:Fasciolidae / Q000187:drug effects*; D005213:Fascioloidiasis / Q000188:drug therapy*; D005260:Female; D008297:Male; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D000077682:Triclabendazole