title: [Acute corticosteroid myopathy in patient with asthma].
abstract: A patient, treated by mechanical ventilation with pancuronium or atracurium and with intravenously administered corticosteroid for status asthmaticus, presented with rhabdomyolysis (severe amyotrophy and marked of creatine kinase activity) and acute flacid and areflexic quadriplegia, involving the proximal and distal muscles but sparing the cephalic musculature. After review of the investigations (biochemistry, electromyogram, muscle biopsy), the diagnostic of acute corticosteroid myopathy following status asthmaticus was suggested, and a pancuronium neuromuscular complication or a critically ill polyneuropathy excluded. The non-inflammatory rhabdomyolysis concerned all the fiber types. Predominantly distal weakness resolved six months after the insult, in spite of the laboratory recurrence of the rhabdomyolysis at the time of a new status asthmaticus briefly treated with corticosteroid.
authors.affiliation: Neurologie, Clinique Saint-Louis, Hôpital Régional du Nord, Ettelbruck, Grand-Duché de Luxembourg.
authors.forename: Y
authors.initials: Y
authors.lastname: De Smet
authors.forename: M
authors.initials: M
authors.lastname: Jaminet
authors.forename: U
authors.initials: U
authors.lastname: Jaeger
authors.forename: J
authors.initials: J
authors.lastname: Jacob
authors.forename: H
authors.initials: H
authors.lastname: Neuray
authors.forename: G
authors.initials: G
authors.lastname: Haus
authors.forename: D
authors.initials: D
authors.lastname: Ledesch-Camus
authors.forename: R
authors.initials: R
authors.lastname: Meyers
mesh_terms: D000208:Acute Disease; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects*; D009135:Muscular Diseases / Q000139:chemically induced* / Q000503:physiopathology; D011782:Quadriplegia / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000139:chemically induced; D013224:Status Asthmaticus / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D008775:Methylprednisolone
vernacular_title: Myopathie aiguë cortisonique de l'asthmatique.