title: Diagnosis of Helicobacter pylori infection in adult and pediatric patients by using Pyloriset, a rapid latex agglutination test.
abstract: Pyloriset (Orion Diagnostica, Espoo, Finland) is a rapid antibody test using latex particles coated with acid-extracted antigen of Helicobacter pylori. We evaluated its ability to predict infection in 100 adult patients and 50 pediatric patients referred for gastric endoscopy. Sixty of 65 H. pylori-infected adults were correctly identified by the test. There were 12 false-positive and 5 false-negative reactions seen. Pyloriset had a sensitivity of 92% and a specificity of 66%. The positive predictive value was 83% and the negative predictive value 82%. In contrast, sensitivity dropped to 36% in the pediatric patients and the positive predictive value was only 40%. Pyloriset could become an important alternative to other more time-consuming diagnostic tests for H. pylori-infected adult patients but is inadequate for diagnosis of pediatric H. pylori infection.
authors.affiliation: Department of Medicine, St. Louis University School of Medicine, Missouri 63104.
authors.forename: T U
authors.initials: TU
authors.lastname: Westblom
authors.forename: E
authors.initials: E
authors.lastname: Madan
authors.forename: S
authors.initials: S
authors.lastname: Gudipati
authors.forename: B R
authors.initials: BR
authors.lastname: Midkiff
authors.forename: S J
authors.initials: SJ
authors.lastname: Czinn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000276:immunology; D001431:Bacteriological Techniques; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007841:Latex Fixation Tests; D008297:Male; D008875:Middle Aged
chemical_list: D000907:Antibodies, Bacterial