title: RBE and OER measurements on the p(66) + Be neutron beam at Faure, South Africa.
abstract: Results reported are for single dose exposures and refer to 60Co-gamma-irradiation. The RBE determined by V79 cell survival and based on the Do ratio was found to be 1.70 +/- 0.4 ranging from 1.5 to 1.8. In the case of the regeneration of mouse jejunal crypts the RBE was calculated at ten cell survival and was found to be 1.68. The maximum acute mouse skin reaction at a skin score of 2.0 was found to be 2.1 while the average skin reaction was 1.7. Growth retardation of Vicia faba bean roots measured at the level of 50% indicated an average RBE of 3.0 and a range of 2.7 to 3.7. The OER obtained for V79 cell survival was found to be 1.7 to 1.8. Comparison is made with the RBE and OER measurements for the neutron facilities at Clatterbridge, Fermilab and Louvain-la-Neuve which produce neutrons by the same nuclear reaction and whose physical specifications closely resemble those of the Faure neutrons. This comparison indicates that the Faure beam shows no unusual biological features and that its biological effectiveness is in line with that expected from its physical characteristics.
authors.affiliation: Radiobiology Laboratory, Faculty of Medicine, University of Stellenbosch.
authors.forename: L
authors.initials: L
authors.lastname: Böhm
authors.forename: G
authors.initials: G
authors.lastname: Blekkenhorst
authors.forename: J P
authors.initials: JP
authors.lastname: Slabbert
authors.forename: F
authors.initials: F
authors.lastname: Verheye
authors.forename: D T
authors.initials: DT
authors.lastname: Jones
authors.forename: M
authors.initials: M
authors.lastname: Yudelev
mesh_terms: D000818:Animals; D001608:Beryllium; D015687:Cell Hypoxia / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects; D003037:Cobalt Radioisotopes; D007887:Fabaceae / Q000528:radiation effects; D005214:Fast Neutrons; D005260:Female; D007583:Jejunum / Q000528:radiation effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010315:Particle Accelerators; D010946:Plants, Medicinal; D011868:Radioisotopes; D012062:Relative Biological Effectiveness; D012867:Skin / Q000528:radiation effects; D013019:South Africa
chemical_list: D003037:Cobalt Radioisotopes; D011868:Radioisotopes; D001608:Beryllium