[Morphogenesis of pneumonia in alcoholic intoxication].
A single moderate dose of ethanol given to 120 Wistar male rats inhibits general immune defence and may facilitate the development of pneumonia. No morphological changes are found in the surfactant system in acute alcoholic intoxication. In chronic alcoholic intoxication with a pronounced withdrawal syndrome, apart from the decrease of general immune defence, lung surfactant system is damaged due to the direct ethanol effect on type II pneumocytes. These are the leading factors in the pneumonia pathogenesis characterized by a grave course and tendency to the abscess formation.
Paukov
V S
VS
Zinov'eva
I A
IA
D000435:Alcoholic Intoxication / Q000150:complications / Q000276:immunology / Q000473:pathology*; D000437:Alcoholism / Q000150:complications / Q000276:immunology / Q000473:pathology*; D000818:Animals; D000431:Ethanol / Q000009:adverse effects; D008297:Male; D011014:Pneumonia / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D011663:Pulmonary Surfactants / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000473:pathology
D011663:Pulmonary Surfactants; D000431:Ethanol
Morfogenez pnevmoniĭ pri alkogol'noĭ intoksikatsii.