title: [Clinical follow-up, histologic findings and therapeutic problems in a patient with bilateral ulcus rodens Mooren].
abstract: A severe, spontaneously acquired, bilateral, sight threatening Ulcus rodens Mooren of a 31 years old type I diabetic will be demonstrated in its clinical course. An improvement was achieved by a systemic immunomodulating therapy with Ciclosporin A that had to be tapered after 3 weeks due to severe side effects. The exclusive local therapy showed no effect at all. Later, the patient underwent a penetrating keratoplasty and extracapsular cataract extraction of both eyes under systemic Ciclosporin A therapy. The graft of the left eye failed due to a foudroyant bacterial infection whereas the keratoplasty of the right eye was successful up to this day despite of various complications.
authors.affiliation: Univ.-Augenklinik Düsseldorf.
authors.forename: V
authors.initials: V
authors.lastname: Rossa
authors.forename: R
authors.initials: R
authors.lastname: Sundmacher
authors.forename: A
authors.initials: A
authors.lastname: Schmitt-Gräff
authors.forename: P
authors.initials: P
authors.lastname: Heering
mesh_terms: D000328:Adult; D002387:Cataract Extraction; D003315:Cornea / Q000473:pathology; D003318:Corneal Opacity / Q000473:pathology; D003319:Corneal Stroma / Q000473:pathology; D003320:Corneal Ulcer / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016572:Cyclosporine / Q000008:administration & dosage; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000473:pathology*; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000473:pathology
chemical_list: D009883:Ophthalmic Solutions; D016572:Cyclosporine
vernacular_title: Klinischer Krankheitsverlauf, histologische Befunde und therapeutische Probleme bei einem Patienten mit einem beidseitigen Ulcus rodens Mooren.