The effect of verapamil on the thermoregulatory responses produced by endotoxin or noradrenaline in rabbits.
1. Thermal responses to verapamil (5 mg/kg per hr) were investigated in pyrogen (lipopolysaccharide Escherichia coli) or noradrenaline (NA) treated rabbits. 2. The compound reduced the pyretic, metabolic and vasoconstricting activity of pyrogen. 3. On the other hand, verapamil did not significantly affect NA-induced hyperthermia. 4. Possible mechanisms responsible for the thermoregulatory activity of verapamil are discussed.
Gagało
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IT
Department of Pharmacology, Medical Academy, Gdańsk, Poland.
Hać
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EE
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D004431:Ear, External / Q000098:blood supply; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D005260:Female; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D012881:Skin Temperature / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology*
D004731:Endotoxins; D014700:Verapamil; D009638:Norepinephrine