title: Influence of anesthesia on the threshold of pacing-induced ischemia.
abstract: Increased myocardial oxygen demand, induced by increased heart rate, may cause myocardial ischemia in the presence of significant coronary artery disease. Alterations in anesthetic depth or technique might put at risk or protect myocardium with compromised blood flow. In 20 dogs with critical left anterior descending coronary artery (LAD) stenosis, atrial pacing rates from 100 to 160 beats/min were achieved, with end-tidal halothane 0.7% (LowH) and 1.1% (HighH), end-tidal isoflurane 1.1% (LowI) and 1.5% (HighI), as well as with continuous fentanyl plus midazolam (FM) infusion anesthesia. Despite significantly different mean arterial and coronary perfusion pressures, rate-pressure product, and left ventricular dP/dtmax, the pacing rate at which systolic shortening decreased below the lower limit of the physiologic response, indicating regional dysfunction, was the same in all investigated anesthesia conditions (LowH: 127 +/- 4 beats/min; HighH: 128 +/- 5 beats/min; LowI: 125 +/- 4 beats/min; HighI: 122 +/- 5 beats/min; FM: 124 +/- 4 beats/min [mean +/- SEM], P greater than 0.05). None of the investigated anesthesia conditions either increased ischemia tolerance or showed a detrimental effect on myocardium with compromised coronary blood flow.
authors.affiliation: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: D R
authors.initials: DR
authors.lastname: Spahn
authors.forename: L R
authors.initials: LR
authors.lastname: Smith
authors.forename: C D
authors.initials: CD
authors.lastname: Veronee
authors.forename: W C
authors.initials: WC
authors.lastname: Hu
authors.forename: R L
authors.initials: RL
authors.lastname: McRae
authors.forename: B J
authors.initials: BJ
authors.lastname: Leone
mesh_terms: D000818:Animals; D002304:Cardiac Pacing, Artificial; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D006221:Halothane / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007530:Isoflurane / Q000494:pharmacology*
chemical_list: D007530:Isoflurane; D006221:Halothane