title: Effect of indomethacin on selected immune parameters in different age groups of mice.
abstract: The authors studied the effect of indomethacin on the phagocytic activity of polymorphonuclear leucocytes (PMNL) and on haemolytic antibody formation (plaques) by lymphoid cells of the spleen in 3-, 6- and 12-month-old mice. In 3- and 12-month-old animals the phagocytic activity of the PMNL was significantly inhibited. Plaque formation was likewise significantly inhibited in 3-month-old mice, but it was significantly raised in 6- and 12-month-old animals.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Safárik University, Kosice.
authors.forename: O
authors.initials: O
authors.lastname: Mahel'ová
authors.forename: A
authors.initials: A
authors.lastname: Linková
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007107:Immune System / Q000187:drug effects / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D013154:Spleen / Q000378:metabolism
chemical_list: D007213:Indomethacin