An in vitro study on mefloquine/quinine in Plasmodium falciparum malaria.
An in vitro designed for determining sensitivity of Plasmodium falciparum strains isolated from Kanchanaburi Province, to Mefloquine/Quinine combination, was carried out. The MIC values of Mefloquine/Quinine for the P.falciparum strains were found to be 0.075/3.75 to 0.225/11.15 nM/ml. The changes observed following the drug treatment were an enlargement of the space between the outer and the inner limiting membrane of the parasitophorous vacuole. These changes were followed by cytoplasmic degeneration and vacuolation.
Jariya
P
P
Department of Parasitology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tiewchaloren
S
S
Mankalanond
K
K
D000818:Animals; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006801:Humans; D015767:Mefloquine / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D011803:Quinine / Q000494:pharmacology*
D004338:Drug Combinations; D011803:Quinine; D015767:Mefloquine