[A pharmacokinetic basis for schedules for administering amikacin to newborn infants].
The use of correlations between the pharmacokinetic parameters and the patient's factors is one of the most promising trends in the elaboration of the efficient regimens of dosage. To establish the analogous correlations in terms of specifying the causes of the widely known individual variability of serum aminoglycoside concentrations in 139 neonates given amikacin for suggested or documented infections, a study was made of the drug pharmacokinetics.
Firsov
A A
AA
Sudilovskaia
N N
NN
Strachunskiĭ
L S
LS
D000375:Aging / Q000097:blood; D000583:Amikacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001724:Birth Weight; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000188:drug therapy; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy; D011379:Prognosis; D013997:Time Factors
D000583:Amikacin
Farmakokineticheskoe obosnovanie skhem vvedeniia amikatsina novorozhdennym.