title: Thymus lymphocytes in uraemic rats and the effect of thymosin fraction 5 in vivo.
abstract: Thymus lymphocyte subsets in uraemic rats were studied using monoclonal antibodies. Severe and moderate uraemia was induced in rats, and sham-operated and normal rats were used as the controls. As a result, the weight of the thymus decreased in uraemic rats. As for lymphocyte subsets, the frequency of W3/25+OX8+ decreased and those of W3/25-OX8-, W3/25+OX8- and W3/25- OX8+ relatively increased in uraemic rats. All these changes were more significant in severely uraemic than in moderately uraemic rats. When thymosin fraction 5 (TF5) was administered to severely uraemic rats, the weight of the thymus increased and the lymphocytes subsets normalized. These results suggest that uraemia may cause a maturational impairment of thymus lymphocytes by the depression of thymic hormone secretion.
authors.affiliation: Department of Urology, Osaka Teishin Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ikemoto
authors.forename: M
authors.initials: M
authors.lastname: Kamizuru
authors.forename: N
authors.initials: N
authors.lastname: Hayahara
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: S
authors.initials: S
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
authors.forename: M
authors.initials: M
authors.lastname: Maekawa
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000943:Antigens, Differentiation / Q000032:analysis; D001835:Body Weight; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013947:Thymosin / Q000494:pharmacology*; D013950:Thymus Gland / Q000473:pathology; D014511:Uremia / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D013947:Thymosin