A morphometric evaluation of the effects of trichloroethylene and dichloroacetylene on the rat mental nerve. Preliminary results.
Morphometric analysis was used to compare the effects of trichloroethylene (Tri) and dichloroacetylene (Dca) on the fibre parameters of the trigeminal nerve. Treated animals were clearly separated from controls according to a discriminant analysis. Furthermore, in the class of nerve fibres defined by a clustering analysis and corresponding to the largest fibres, myelin thickness was significantly decreased in the Dca group, but less so in the Tri group. In the group of the smallest fibres however, the myelin thickness was significantly increased by the treatments, but especially by Tri. Such a variability in the effects of Tri has already been demonstrated. Mechanisms for this are quite unclear although demyelination could be involved as already suggested. Our results thus show the ability of Tri and Dca to alter nerve parameters but probably with different modes of action depending on the size of the fibre.
Barret
L
L
Laboratoire de Toxicologie, CHU de Grenoble, France.
Torch
S
S
Usson
Y
Y
Gonthier
B
B
Saxod
R
R
D000114:Acetylene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D009186:Myelin Sheath / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D014241:Trichloroethylene / Q000008:administration & dosage / Q000633:toxicity*; D014276:Trigeminal Nerve / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure
D014241:Trichloroethylene; C002978:dichloroacetylene; D000114:Acetylene