title: [Neurotensin liberation during the consumption of mineral water from Bad Mergentheimer Karlsquelle].
abstract: The contraction of the gallbladder mainly mediated by CCK after oral administration of pharmacological doses of magnesium sulfate is familiar. The same applies to the cholekinetic action of courses of sulfatic mineral water treatment. It was demonstrated in 12 patients in a controlled study that besides other known secretions of gastrointestinal hormones, there is also a significant rise of the plasma level of neurotensin when Bad Mergentheimer Karlsquelle mineral water containing sulfate (3.7 g SO4/l) is drunk on an empty stomach (300 ml, 26 degrees C). This was significantly greater (basal values 6.8 +/- 4.1 pg/ml and a maximum of 15.7 +/- 8.1 pg/ml after 40 min) than in a control group consisting of the same patients who had drunk tapwater. Whereas the involvement of the neuropeptide neurotensin in the regulation of the exocrine functions of the pancreas has been established, its effect in the regulation of gallbladder contraction is probably of rather minor significance compared to CCK.
authors.affiliation: Klinik Rosenberg LVA Westfalen, Bad Driburg.
authors.forename: G
authors.initials: G
authors.lastname: Eberhardt
authors.forename: A
authors.initials: A
authors.lastname: Dersidan
authors.forename: R
authors.initials: R
authors.lastname: Nustede
authors.forename: A
authors.initials: A
authors.lastname: Schafmayer
mesh_terms: D000328:Adult; D005260:Female; D016473:Gallbladder Emptying / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D008900:Mineral Waters / Q000737:chemistry; D009496:Neurotensin / Q000097:blood*
chemical_list: D008900:Mineral Waters; D009496:Neurotensin; D008278:Magnesium Sulfate
vernacular_title: Neurotensinfreisetzung beim Trinken von Bad Mergentheimer Karlsquelle.