Interleukin-1 kinetics in hemodialysis.
Interleukin-1 (IL-1) was measured in the plasma and in mononuclear cell (MC) lysates from patients on maintenance hemodialysis (HD) using either cuprophan (CU) or polysulfone (PS) membranes. Basal plasma levels of IL-1 in HD patients were significantly higher than those of uremic patients on conservative treatment or of healthy subjects. In 10 patients on conservative treatment, plasma levels of IL-1 increased significantly after 3 and 6 months of HD. During a single HD session, plasma IL-1 fell to 21% (CU) and 22% (PS) of pre-HD levels. Hemodialysis patients had a significantly higher intracellular IL-1 content than normal controls. During HD, a further increase was seen regardless of the membrane employed. A parallel in vitro study showed that IL-1 produced during HD requires at least 24 hours to be released, and that both CU and PS are able to bind and clear IL-1.
Donati
D
D
Department of Pathology, UMDNJ-Robert Wood Johnson Medical School, Piscataway.
Degiannis
D
D
Homer
L
L
Raska
K
K
Raskova
J
J
D000328:Adult; D000368:Aged; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D008875:Middle Aged; D006435:Renal Dialysis; D014511:Uremia / Q000276:immunology
D007375:Interleukin-1