Antithromboxane drug in the treatment of preeclampsia.
In this study, we present our initial trials in the treatment of 6 cases of severe preeclampsia with thromboxane synthetase inhibitor (OKY-046). Following the treatment with OKY-046, maternal systolic blood pressure decreased significantly and umbilical artery waveforms were normalized. These data suggest that thromboxane synthetase inhibition might have a beneficial effect on preeclampsia.
Furuhashi
N
N
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
Tsujiei
M
M
Kimura
H
H
Okamura
K
K
Yajima
A
A
D000328:Adult; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008689:Methacrylates / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D008689:Methacrylates; D013930:Thromboxane-A Synthase; C034364:ozagrel