title: Destruction of different fiber tracts underlies development of lateral hypothalamic lesion-induced hyperthermia and loss of bombesin-induced hypothermia.
abstract: The relative roles of lateral hypothalamic cell bodies and fibers of passage were assessed in the development of lesion-induced hyperthermia and bombesin-induced hypothermia. Electrolytic lesions or discrete fiber transections were combined with intracisternal bombesin injection to show that each of these two thermoregulatory effects involves fibers crossing the borders of the lateral hypothalamus; however, the two effects primarily involve fibers crossing different borders. Thus, the hyperthermia and the abolition of bombesin-induced hypothermia which follow lateral hypothalamic damage appear to result from disruption of separate thermoregulatory pathways.
authors.affiliation: Geriatric Research, Sepulveda Veterans Affairs Medical Center, CA 91343.
authors.forename: M W
authors.initials: MW
authors.lastname: Gunion
authors.forename: C V
authors.initials: CV
authors.lastname: Grijalva
authors.forename: Y
authors.initials: Y
authors.lastname: Taché
authors.forename: D
authors.initials: D
authors.lastname: Novin
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001839:Bombesin; D002946:Cisterna Magna; D003714:Denervation; D005334:Fever / Q000209:etiology*; D007026:Hypothalamic Area, Lateral / Q000502:physiology*; D007035:Hypothermia / Q000139:chemically induced*; D007267:Injections; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001839:Bombesin