title: Grain dust and lung function. Dose-response relationships.
abstract: Grain dust exposure has been associated with both acute and chronic respiratory abnormalities. We sought to answer two questions with regard to this exposure: (1) is there a dose-response relationship between grain dust and respiratory abnormalities, and (2) is there evidence to suggest that the allowable exposure (currently 10 mg/m3 in Canada) be lowered? We compared respiratory symptoms and lung function among 454 grain elevator workers and 55 civic workers to estimates of lifetime average grain dust exposure. A total of 781 personal air samples representing 20 different job titles over a 15-yr period were used to construct a job title-time period matrix for average dust exposure levels. The matrix was applied to each worker's detailed job history to obtain a value for estimated cumulative and average dust exposure. Significant dose-response relationships were seen for chronic phlegm production, breathlessness on exertion, FEV1, and FVC; and dose-response trends were evident for the longitudinal change in both FEV1 and FVC. Workers with estimated average exposure between 4 and 9 mg/m3 were found to have significantly lower values for FEV1 and FVC compared to both grain workers exposed to less than 4 mg/m3 on average and civic workers, despite no difference in duration of employment among these groups. The results indicate a strong dose-response relationship between grain dust exposure and both respiratory symptoms and lung function and also suggest that the current Canadian allowable exposure level of 10 mg/m3 is too high.
authors.affiliation: Department of Medicine, University of British Columbia, Vancouver, Canada.
authors.forename: T
authors.initials: T
authors.lastname: Huy
authors.forename: K
authors.initials: K
authors.lastname: De Schipper
authors.forename: M
authors.initials: M
authors.lastname: Chan-Yeung
authors.forename: S M
authors.initials: SM
authors.lastname: Kennedy
mesh_terms: D001955:British Columbia / Q000453:epidemiology; D003430:Cross-Sectional Studies; D002523:Edible Grain; D006801:Humans; D008137:Longitudinal Studies; D008452:Maximum Allowable Concentration; D016273:Occupational Exposure; D011009:Pneumoconiosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D015995:Prevalence; D012129:Respiratory Function Tests; D012907:Smoking / Q000453:epidemiology