Dielectric properties of the system bovine albumin: urea: betaine in aqueous solution.
Urea (about 5 mol l-1) causes an approximately five-fold increase of the dielectric increment of bovine serum albumin at 20 degrees C. The increase is reversed by betaine (about 2.5 mol l-1), or prevented if urea and betaine are added together. This result can be seen as an electric counterpart to the protective role of osmolytes which are secreted by cells and tissues subjected to various types of internal or environmental stress.
Bateman
J B
JB
Department of Physics, King's College, Strand, London, UK.
Evans
G F
GF
Brown
P R
PR
Gabriel
C
C
Grant
E H
EH
D001622:Betaine; D004336:Drug Antagonism; D004357:Drug Synergism; D004553:Electric Conductivity; D011487:Protein Conformation; D012710:Serum Albumin, Bovine; D012996:Solutions; D014508:Urea; D014867:Water
D012996:Solutions; D014867:Water; D012710:Serum Albumin, Bovine; D001622:Betaine; D014508:Urea