title: [Combined approach to malignant tumors of the ethmoid and other paranasal sinuses. Principles and results].
abstract: The authors present their experience concerning combined transfacial and neurosurgical procedures in the treatment of carcinomas of the ethmoid sinuses. 109 ethmoid-spheno-orbital tumors were treated at our department from 1982 to 1990: 85 were located into the ethmoidal and/or sphenoidal sinuses; 78 of these were malignant. Among the 65 ethmoidal carcinomas which were operated through a combined route, 48 underwent an induction chemotherapy and 19 a post-operative radiotherapy. The surgical technique is detailed, mostly the intra-cranial approach and the reconstruction of the cranial basis. Clinical results, and particularly the actuarial survival rates are discussed. The 5-year actuarial survival rate is 40% for all first hand ethmoidal adenocarcinomas. The figure reaches 52% for the patients without intra-cranial extension. At last, the 5-year actuarial survival rate is 100% for patients having a complete clinical response to induction chemotherapy.
authors.affiliation: Service de Neurochirurgie, Centre Hospitalier Sainte-Anne, Paris.
authors.forename: F X
authors.initials: FX
authors.lastname: Roux
authors.forename: D
authors.initials: D
authors.lastname: Brasnu
authors.forename: M
authors.initials: M
authors.lastname: Menard
authors.forename: G
authors.initials: G
authors.lastname: Schwaab
authors.forename: F
authors.initials: F
authors.lastname: Janot
authors.forename: J
authors.initials: J
authors.lastname: Lacau St-Guily
authors.forename: J
authors.initials: J
authors.lastname: Trotoux
authors.forename: O
authors.initials: O
authors.lastname: Laccourreye
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005005:Ethmoid Sinus; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*
chemical_list: D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Les abords combinés des tumeurs malignes de l'ethmoïde et autres sinus paranasaux Principes et résultats.