Chromosomal abnormalities in childhood acute nonlymphocytic leukemia (M4).
A new reciprocal, apparently balanced translocation between chromosomes 7 and 22, i.e., t(7;22)(p22;q13), in association with inv(16)(p13q22) in a child with acute nonlymphocytic leukemia (M4) is reported. Five percent of her bone marrow cells contained both of these aberrations while 90% of her cells have the pericentric inversion of chromosome 16 as the sole abnormality. A clonal evolution of the unusual cell line may be associated with atypical clinical presentation. The presence of inversion 16 in adults has a better prognosis as compared with children. A concise review on the cytogenetic findings in children with ANLL(M4) is also provided.
Mostafavipour
S H
SH
Hamad Medical Corporation, Doha, Qatar.
Abulaban
M
M
Alali
K
K
al Zaman
A
A
Macera
M J
MJ
Verma
R S
RS
D002648:Child; D002869:Chromosome Aberrations / Q000473:pathology; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D014178:Translocation, Genetic