Amantadine neurotoxicity in a pediatric patient with renal insufficiency.
Amantadine hydrochloride, a dopamine agonist with antiviral and antiparkinsonism properties, is used for the prevention and treatment of influenza A respiratory infections in high-risk populations. The occurrence of amantadine-induced hallucinations and tremors is described in a young, renal transplant patient with declining renal function. Following discontinuation of amantadine, plasma amantadine concentrations were correlated with central nervous system toxicity. In view of the usage of amantadine in renal transplant recipients and the elderly, clinicians must be alert to the possibility of amantadine-induced neurotoxicity in patients with changing renal function.
Strong
D K
DK
Pharmacy Department, Hospital for Sick Children, Toronto, Ontario, Canada.
Eisenstat
D D
DD
Bryson
S M
SM
Sitar
D S
DS
Arbus
G S
GS
D000293:Adolescent; D000547:Amantadine / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D003401:Creatine / Q000097:blood / Q000652:urine; D005260:Female; D006084:Graft Rejection; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007674:Kidney Diseases / Q000188:drug therapy*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D012086:Reoperation; D014202:Tremor / Q000139:chemically induced
D007166:Immunosuppressive Agents; D000547:Amantadine; D003401:Creatine