title: [Relevance and therapeutic implications of dysplasia in the follow-up of ulcerative rectocolitis].
abstract: Long standing ulcerative colitis (UC) is a condition capable of malignant transformation. Even if the rate of occurrence of carcinoma differs considerably among the various series, there is general agreement that it can be detectable in advance through the finding of glandular dysplasia. The Authors examine such a problem in a series of 27 patients submitted to clinical and endoscopic follow-up from 1984 to 1989. During this study a total of 237 rectosigmoidoscopies, 83 colonoscopies and 71 histologic exams were performed. At the outset mild or moderate dysplasia was found in 5 cases (18%). However, in the follow-up no evidence of dysplasia was detectable in 4 of the 5 cases. In the remaining case dysplasia was present only in one control. It was not found in the subsequent two histologic examinations. In our limited experience the incidence of dysplasia was not significant enough to require a prophylactic proctocolectomy. Instead a frequent and thorough endoscopic follow-up is recommended.
authors.affiliation: Istituto di Chirurgia, Università degli Studi di Cagliari.
authors.forename: G
authors.initials: G
authors.lastname: Pisano
authors.forename: P
authors.initials: P
authors.lastname: Ledda
authors.forename: C
authors.initials: C
authors.lastname: Goffi
authors.forename: M
authors.initials: M
authors.lastname: Pomata
authors.forename: C
authors.initials: C
authors.lastname: Pani
authors.forename: G P
authors.initials: GP
authors.lastname: Farina
mesh_terms: D000293:Adolescent; D000328:Adult; D003093:Colitis, Ulcerative / Q000473:pathology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*; D011351:Proctoscopy
vernacular_title: Significato ed implicazioni terapeutiche della displasia nel controllo della rettocolite ulcerosa.