title: Effect of RU-38486 on dexamethasone reversal of morphine-induced constipation in mice.
abstract: 1. Morphine and dexamethasone significantly reduce gastrointestinal transit in mice. The degree of reduction was greater for morphine. 2. Dexamethasone pretreatment was found, however, to antagonize morphine-induced constipation. 3. Cycloheximide does not modify the dexamethasone effects. 4. RU-38486 reverses both the inhibitory action of dexamethasone on gastrointestinal transit and its reducing effect on morphine-induced constipation. 5. These results suggest that dexamethasone might act through binding to receptors not linked to DNA-responsive elements.
authors.affiliation: Department of Experimental Pharmacology, University of Naples Federico II, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Persico
authors.forename: A
authors.initials: A
authors.lastname: Capasso
authors.forename: A
authors.initials: A
authors.lastname: Calignano
authors.forename: L
authors.initials: L
authors.lastname: Sorrentino
mesh_terms: D000818:Animals; D003248:Constipation / Q000139:chemically induced*; D003513:Cycloheximide / Q000494:pharmacology; D003907:Dexamethasone / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D005772:Gastrointestinal Transit / Q000187:drug effects; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D015735:Mifepristone / Q000494:pharmacology*; D009020:Morphine / Q000037:antagonists & inhibitors*
chemical_list: D015735:Mifepristone; D009020:Morphine; D003907:Dexamethasone; D003513:Cycloheximide