Effects of an androgenic derivative on pre-established mammary tumours chemically induced in the rat.
The effects were studied of an androgenic derivative--danazol--administered at doses of 10-12 mg kg-1 day-1 during 97 days to rats with dimethylbenz[a] anthracene-induced mammary tumours. Our main observations were as follows. (a) Danazol did not influence ovarian function at the end of the assay. (b) The treatment with danazol reduced the incidence (P less than 0.05), number of tumours (P less than 0.05) and volume of malignant mammary tumours; on the other hand, the values of these parameters for benign tumours and those of doubtful expression were similar in both experimental groups. (c) Such differential action of Danazol seems to be due to the different incidence and/or content of receptors of both types of tumours. (d) The latter results lead to a hypothesis for the mechanism of action of danazol based on its behaviour at different levels.
Escrich
E
E
Departament de Biologia Cellular i Fisiologia, Facultat de Medicina, Universitat Autónoma de Barcelona, Spain.
Ribalta
T
T
Muntané
J
J
Ruiz de Villa
M C
MC
Murillo
J
J
Saez
S
S
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D003613:Danazol / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010053:Ovary / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000096:biosynthesis; D011980:Receptors, Progesterone / Q000096:biosynthesis
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D003613:Danazol