title: Lethal progeroid syndrome with osteolysis. Case report.
abstract: A particular progeroid syndrome with severe acro-osteolysis, cutaneous changes, failure to thrive, and early death is described in a young boy. Progeria and mandibulo-acral dysplasia are discussed, but early death is unusual in these two syndromes. This observation raises the question of a large spectrum including all of these syndromes.
authors.affiliation: U12, Unité de Recherches INSERM sur les Handicaps Génétiques de l'Enfant, Hôpital des Enfants-Malades, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Le Merrer
authors.forename: M
authors.initials: M
authors.lastname: Guillot
authors.forename: M L
authors.initials: ML
authors.lastname: Briard
authors.forename: P
authors.initials: P
authors.lastname: Maroteaux
mesh_terms: D006801:Humans; D007223:Infant; D008297:Male; D008334:Mandible / Q000002:abnormalities*; D010014:Osteolysis; D010641:Phenotype; D011371:Progeria; D011379:Prognosis; D013577:Syndrome