The effect of glycerol on the guinea-pig hydropic ear.
The aim of this paper was to investigate the effect of glycerol on experimental endolymphatic hydrops in guinea-pigs. The right endolymphatic sac and duct were obliterated through an extradural posterior fossa approach. Some animals received a 3 g/kg dose of glycerol for a period of 7 days, whereas others received the same dose for 30 days. The activity of glycerol was studied by investigating the volumetric changes in the scala media determined with a computerized planimeter. Glycerol induced a significant reduction of the hydrops showing its effectiveness and suggesting a strial metabolic response.
Magliulo
G
G
2nd ENT Department, University La Sapienza, Rome, Italy.
Ungari
C
C
Della Rocca
C
C
Muscatello
M
M
Vingolo
G M
GM
D000818:Animals; D003053:Cochlear Duct / Q000473:pathology; D004487:Edema / Q000188:drug therapy* / Q000473:pathology; D004710:Endolymph; D005990:Glycerol / Q000627:therapeutic use*; D006168:Guinea Pigs; D007759:Labyrinth Diseases / Q000188:drug therapy / Q000473:pathology; D008575:Meniere Disease / Q000188:drug therapy / Q000473:pathology; D009925:Organ of Corti / Q000473:pathology; D013136:Spiral Ganglion / Q000473:pathology; D013316:Stria Vascularis / Q000473:pathology
D005990:Glycerol