title: Efficacy of SCH 39304 in treatment of experimental invasive aspergillosis.
abstract: The efficacy of SCH 39304 (SCH) against Aspergillus fumigatus was assessed with an immunosuppressed, temporarily leukopenic rabbit model of invasive aspergillosis. Therapy with SCH at 10 or 15 mg/kg of body weight per day was begun 24 h after lethal challenge and compared with therapy with amphotericin B at 1.5 mg/kg/day. Compared with untreated controls, SCH reduced mortality and also reduced the tissue burden of A. fumigatus 100- to 1,000-fold in liver, kidney, and lung tissues. SCH at 15 mg/kg/day and amphotericin B eliminated A. fumigatus in liver, kidney, and lung tissues. In addition, both dosages of SCH significantly eliminated the organism from brain tissues, compared with controls. Both SCH and amphotericin B decreased or eliminated circulating aspergillus antigen. These results show that new azoles can be as effective as amphotericin B in eradicating the organism from tissues and offer promise in improving the treatment of invasive aspergillosis.
authors.affiliation: Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
authors.forename: T F
authors.initials: TF
authors.lastname: Patterson
authors.forename: D
authors.initials: D
authors.lastname: George
authors.forename: R
authors.initials: R
authors.lastname: Ingersoll
authors.forename: P
authors.initials: P
authors.lastname: Miniter
authors.forename: V T
authors.initials: VT
authors.lastname: Andriole
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000946:Antigens, Fungal / Q000032:analysis; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D007165:Immunosuppression Therapy; D007970:Leukopenia / Q000382:microbiology; D011817:Rabbits; D014230:Triazoles / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D000946:Antigens, Fungal; D014230:Triazoles; C056513:Sch 39304; D000666:Amphotericin B