On the mechanisms and clinical relevance of one-kidney, one-clip hypertension.
Dr. Skeggs demonstrated the lack of renin dependence in 1-kidney, 1-clip hypertension and elucidated some of the differences between that and Dr. Goldblatt's classic 2-kidney, 1-clip model of hypertension. Studies of these two different types of hypertension have led research in many new directions and helped to reveal the role of the renin-angiotensin system in hypertension and that system's interaction with sodium-induced vasodilation in both animals and humans. More recent research has investigated the processes behind essential hypertension and I present here the proposal that, due to nephron heterogeneity, essential hypertension in humans is parallel in its pathophysiologic processes to Goldblatt hypertension.
Laragh
J H
JH
New York Hospital-Cornell Medical Center, New York City 10021.
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D007668:Kidney / Q000502:physiology*