[Pituitary and plasma levels of growth hormone (GH), follicle stimulating hormone (FSH) and luteinizing hormone (LH) in hereditary dwarf rats (rdw/rdw)].
Koto et al found a new hereditary dwarf mutation from breeding colony of Wistar-Imamichi rat and named 'rdw'. To characterize endocrinological functions in rdw rats, pituitary and plasma levels of pituitary hormones including growth hormone (GH), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were compared between rdw and normal rats. The hormone levels were estimated with radioimmunoassay (RIA). It was found that pituitary and plasma levels of GH of rdw were drastically decreased and those of FSH and LH were inclined to decrease but not remarkable as compared with normal. Rats of rdw were, therefore, considered to be useful as a model animal for endocrinological defects.
Umezu
M
M
Laboratory of Animal Reproduction, Faculty of Agriculture, Tohoku University, Miyagi, Japan.
Kawada
K
K
Miwa
A
A
Ishii
S
S
Masaki
J
J
D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D004393:Dwarfism, Pituitary / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000378:metabolism*; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland / Q000378:metabolism*; D011863:Radioimmunoassay; D051381:Rats; D011922:Rats, Mutant Strains
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone