[Effect of alpha-tocopherol and selenium on the activity of antioxidant enzymes and level of lipid peroxidation products in erythrocytes of patients with cerebral ischemia].
Antioxidant drugs: alpha-tocopherol acetate and "Selenium" (Finland) were used in treatment of patients with small ischemic insult and middle severity ischemic insult; the state of endogenous antioxidant system and intensity of lipid peroxidation were studied in erythrocytes within various periods of diseases. Content of diene conjugates and malonic dialdehyde was decreased, while activity of superoxide dismutase, catalase, glutathione peroxidase and reductase was increased after administration of both these antioxidants during treatment of the brain circulation impairments. Simultaneous use of the drugs caused the highest effect which occurred due to their influence on various pathways of the endogenous antioxidant system.
Dzhandzhgava
T G
TG
Shakarishvili
R R
RR
D000975:Antioxidants; D002545:Brain Ischemia / Q000097:blood*; D002374:Catalase / Q000378:metabolism; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D012643:Selenium / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D014810:Vitamin E; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D012643:Selenium
Vliianie alpha-tokoferola i selena na aktivnost' antioksidantnykh fermentov i soderzhanie produktov perekisnogo okisleniia lipidov v éritrotsitakh bol'nykh ishemicheskoĭ bolezn'iu mozga.