Temperature dependence of carbachol-induced modulation of miniature end-plate potential frequency in rats.
In the rat soleus, the frequency of miniature end-plate potentials (MEPP) did not change after application of 10(-5) M of the cholinomimetic drug carbachol between 18 degrees C and 34 degrees C but decreased by 40% at physiological temperatures of 37-38 degrees C. The carbachol-induced decrease in MEPP frequency was not eliminated by 10(-7) to 10(-8) M atropine or 3 x 10(-7) (+)-tubocurarine similarly as had been previously found at frog neuromuscular junction.
Nikolsky
E E
EE
Kazan Medical Institute, Tatar Autonomic Republic, U.S.S.R.
Strunsky
E G
EG
Vyskocil
F
F
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D004594:Electrophysiology; D008297:Male; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013696:Temperature
D002217:Carbachol