Localization of basic fibroblast growth factor in a subpopulation of rat sensory neurons.
The distribution of basic fibroblast growth factor (bFGF)-immunoreactivity (IR) was studied in rat sensory and autonomic ganglia. In postnatal and adult sympathetic superior cervical ganglia and in adult parasympathetic otic ganglia no bFGF-staining was found. Postnatal and adult neural crest- and placode-derived sensory ganglia displayed intensive bFGF-IR in a neuronal subpopulation. This subpopulation was characterized by use of consecutive sections of adult dorsal root ganglia stained with antibodies against substance P, somatostatin, bombesin, and bFGF. Basic FGF was colocalized with the somatostatin/bombesin subpopulation but not with substance P.
Weise
B
B
Institut für Anatomie und Zellbiologie Universität, Marburg, Federal Republic of Germany.
Unsicker
K
K
Grothe
C
C
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005724:Ganglia / Q000166:cytology / Q000378:metabolism*; D005725:Ganglia, Autonomic / Q000166:cytology / Q000378:metabolism; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D016222:Fibroblast Growth Factor 2