Experimental evaluation of a new type of heparin-bonded polyurethane.
A new type of heparin bonding method using polyurethane (H-PU) in an ionically equivalent manner was examined experimentally. In vitro testing of polyvinylchloride tubes with this coating showed that the behavior of the heparin was attributed to the activation of retained heparin on the surface. After 4 hrs of heparinless arterio-arterial bypass in a canine model with a central shear rate of 25 sec-1 (inner diameter, 0.8 x 80 cm), macroscopic and scanning electron microscopic examinations showed that the H-PU coated tube had better antithrombogenicity than that of a conventional PU coated tube (Pellethane). These results suggest that this heparin bonding method with PU appears to have good antithrombogenicity with possible long durability.
Chang
J C
JC
First Department of Surgery, Osaka University Medical School, Japan.
Miyamoto
Y
Y
Nakano
S
S
Kaneko
M
M
Matsuwaka
R
R
Matsuda
H
H
Iida
K
K
Kaneko
N
N
Shimomura
Y
Y
D000818:Animals; D001807:Blood Vessel Prosthesis; D004285:Dogs; D006083:Graft Occlusion, Vascular / Q000097:blood; D006493:Heparin; D006801:Humans; D008855:Microscopy, Electron, Scanning; D011140:Polyurethanes; D011474:Prosthesis Design; D011517:Prothrombin Time; D013499:Surface Properties
D011140:Polyurethanes; D006493:Heparin