title: Fluid-shift during computer-modulated profile hemodialysis (CMP-HD).
abstract: Computer-modulated profile hemodialysis was examined for patients' comfort and fluid-shift. Fifteen patients were studied after two weeks of dialysis with each of the following profiles: A): constant ultrafiltration (UF) and dialysate sodium (138 mmol/l); B): decreasing UF; C): decreasing UF and decreasing high dialysate sodium (starting 10% above serum-sodium, with a gradual reduction to 138 mmol/l in the fourth hour). Patients with a calculated increase of intracellular volume (ICV) during dialysis had more complaints after dialysis than the others. ICV decreased in all patients with low serum-sodium (less than 136 mmol/l) during all profiles, whereas in patients with higher sodium, only profile C led to a decrease of ICV. However, interdialytic weight gain increased about 75% in patients with low serum-sodium under profile C. The sodium profile could help in preventing imbalance without side effects in patients with high sodium.
authors.affiliation: Department of Nephrology, Philipps-University of Marburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Keuchel
authors.forename: A
authors.initials: A
authors.lastname: Dittmar
authors.forename: B
authors.initials: B
authors.lastname: Saure
authors.forename: C
authors.initials: C
authors.lastname: Laage
authors.forename: H
authors.initials: H
authors.lastname: Ebel
authors.forename: H
authors.initials: H
authors.lastname: Lange
mesh_terms: D000368:Aged; D001794:Blood Pressure; D005260:Female; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods; D012964:Sodium / Q000097:blood; D013813:Therapy, Computer-Assisted; D014882:Water-Electrolyte Balance; D015430:Weight Gain
chemical_list: D012964:Sodium