title: Bone marrow aplasia in B cell chronic lymphocytic leukaemia: successful treatment with antithymocyte globulin.
abstract: Pure red cell aplasia is a rare but well known association of chronic lymphocytic leukaemia (CLL). Pancytopenia due to bone marrow aplasia has not been previously described in CLL. A 42 year old man with B cell CLL became severely pancytopenic with bone marrow aplasia. Bone marrow culture resulted in a greatly reduced colony formation. High dose corticosteroids and intravenous immunoglobulin treatment were unsuccessful. Prompt and complete marrow recovery ensued after administration of antithymocyte globulin.
authors.affiliation: Department of Haematology, Royal Hallamshire Hospital, Sheffield.
authors.forename: R
authors.initials: R
authors.lastname: Singal
authors.forename: D A
authors.initials: DA
authors.lastname: Winfield
authors.forename: M
authors.initials: M
authors.lastname: Greaves
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000209:etiology / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000473:pathology; D008297:Male; D010198:Pancytopenia / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000961:Antilymphocyte Serum