title: A 2-year longitudinal study of lung hyperinflation in young asthmatics.
abstract: Functional residual capacity (FRC) was measured at 6-monthly intervals for at least 2 years in 42 young asthmatic children. Over the 2-year period FRC decreased in the 42 children from a median of 136% to 117% of that predicted for height (P less than 0.05). These changes in FRC were associated with a reduction in the number of children receiving no regular treatment (ten at recruitment, 0 at 2 years), P less than 0.05, and an increase in the number of children receiving inhaled steroids (ten at recruitment and 29 at 2 years), P less than 0.01. Twenty-five children were hyperinflated at recruitment (FRC greater than 120% of that predicted for height) with median FRC 152% compared to only 16 children at 2 years median FRC 117%, P less than 0.01. We conclude that FRC decreases as asthmatic children get older but some children, worryingly and despite increased use of prophylactic therapy, remain chronically overdistended which may put them at serious risk of chronic obstructive airways disease in later life.
authors.affiliation: Paediatric Respiratory Laboratory, King's College Hospital, London, U.K.
authors.forename: A
authors.initials: A
authors.lastname: Greenough
authors.forename: L
authors.initials: L
authors.lastname: Everett
authors.forename: J
authors.initials: J
authors.lastname: Pool
authors.forename: J F
authors.initials: JF
authors.lastname: Price
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D005652:Functional Residual Capacity / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007223:Infant; D008168:Lung / Q000503:physiopathology*; D013256:Steroids
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids