On the role of 26-deoxylaidlomycin in laidlomycin biosynthesis.
3H-26-deoxylaidlomycin (I) was fed to growing cultures of Streptoverticillium olivoreticuli IMET 43782 producing both I and laidlomycin (II). The incorporation of labelled I into laidlomycin II was neglible showing a role of I as precursor of II to be at variance. Otherwise, a measurable conversion was achieved by the use of sonicated 48 hrs mycelium suggesting that final oxidation of I to II could be mediated by a compartmentized oxidoreductase.
Gräfe
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U
Institut für Mikrobiologie und experimentelle Therapie, Jena.
Stengel
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C
D005285:Fermentation; D008985:Monensin / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000378:metabolism; D010084:Oxidation-Reduction; D013306:Streptomycetaceae / Q000378:metabolism*
C062367:26-deoxylaidlomycin; D008985:Monensin; C010208:laidlomycin