title: Angiosarcoma of the skin overlying an irradiated breast.
abstract: A case of angiosarcoma of the breast which developed six and a half years after treatment for carcinoma of the same breast is reported. As a result of radiotherapy the breast manifested signs of chronic lymphedema prior to development of angiosarcoma. Although the aetiology in this case is uncertain, there was a past history of childhood naevus regressing spontaneously. Angiosarcoma is a well known complication following radiotherapy and lymphedema, and is likely to be seen more frequently as conservation treatment is used more commonly for patients with early breast cancer.
authors.affiliation: ICRF Clinical Oncology Unit, Guy's Hospital, London, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Badwe
authors.forename: A M
authors.initials: AM
authors.lastname: Hanby
authors.forename: I S
authors.initials: IS
authors.lastname: Fentiman
authors.forename: M A
authors.initials: MA
authors.lastname: Chaudary
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006394:Hemangiosarcoma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology*