Idiopathic Parkinson's disease combined with multiple system atrophy. A clinicopathological report.
The clinical and postmortem findings of a patient with Lewy body pathology combined with multiple-system atrophy are described. When alive the patient was diagnosed as having Parkinson's disease. Pathological examination found evidence of striatonigral and olivopontocerebellar degeneration, together with Lewy bodies at a number of sites characteristic for idiopathic Parkinson's disease. Taken together, the clinical history and histological findings support the coexistence of two disease processes.
Hughes
A J
AJ
Department of Neurology, School of Medicine, University College and Middlesex Hospitals, London, England.
Daniel
S E
SE
Lees
A J
AJ
D001253:Astrocytes / Q000473:pathology; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis / Q000473:pathology*; D001921:Brain / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology*; D005911:Gliosis / Q000473:pathology; D006801:Humans; D016631:Lewy Bodies / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology*; D009460:Neurologic Examination; D009849:Olivopontocerebellar Atrophies / Q000175:diagnosis / Q000473:pathology*; D010300:Parkinson Disease / Q000175:diagnosis / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology*