[Relationship between free radicals and diabetic microangiopathy].
Lipid peroxide (LPO) values in blood plasma, along with the glutathione peroxidase (GSH-PX) activity in whole blood and superoxide dismutase (SOD) activity in erythrocytes were determined in 50 patients with non-insulin-dependent diabetes mellitus (NIDDM) and in 33 control subjects. The mean LPO value, SOD activity, LPO/GSH-PX and LPO/SOD ratios in the diabetic patients were significantly higher than those in the control subjects. The increases of LPO value, LPO/GSH-PX and LPO/SOD ratios were more pronounced in diabetics with microangiopathy than in those without microangiopathy. Our results suggest that free radicals may be implicated in the pathogenesis of diabetic microangiopathy.
Li
H
H
Department of Internal Medicine, First Affiliated Hospital, ZhejiangMedical University, Hangzhou.
Tang
Z H
ZH
Xia
T Q
TQ
D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005609:Free Radicals; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D013482:Superoxide Dismutase / Q000097:blood*
D005609:Free Radicals; D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase