[In vitro drug interactions and their importance in anesthesiologic practice].
The potential for in vitro drug interactions is great in anaesthesiology because of routine intravenous comedication. When the drug is applied directly into (via) the injection port of the cannula most of these interactions are overlooked, whereas others show no visible signs. Chemical interactions depend on pH changes, formation of insoluble salts, oxidation and reduction, complex formation, or hydrolysis. Physical interactions are caused by changing of solvent system polarity, salting out, emulsion cracking or sorption. Solving the problem requires information (1) and precautions in respect of the mode of application (2). (1) Anaesthesiologists should know the most frequent mechanisms. Glucose infusions cannot be considered as safe carrier solutions for admixtures. Pharmacological databases should offer as much information as possible on incompatibility. (2) Injections into a separate line or lumen with a sodium chloride infusion are safe. Admixture is recommended only if compatibility is known.
Dirks
B
B
Universitätsklinik für Anästhesiologie, Klinikum der Universität Ulm.
Schmitz
J E
JE
Kilian
J
J
D000776:Anesthesiology; D004344:Drug Incompatibility; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques
In-vitro-Arzneimittelinteraktion und ihre Bedeutung für die anästhesiologische Praxis.