Morphological characteristics of the endocrine pancreas in alloxan diabetes after cyclosporin A administration.
Histological, immunocytochemical, morphometric and electron microscope studies were carried out on the pancreas of alloxan diabetic rats pretreated with cyclosporin A. High mortality, severe destruction of pancreatic B-cells and presence of sporadic mononuclear infiltrations in islets and around excretory ducts were observed. The results obtained show that cyclosporin A potentiates the toxic effect of alloxan on the pancreatic B-cells.
Zafirova
M
M
Department of Anatomy and Histology, Faculty of Medicine, Bulgarian Academy of Sciences, Sofia.
Jablenska
R
R
Popov
A
A
Goranova
I
I
Vassileva
E
E
Duhault
J
J
Marquie
G
G
Petkov
P
P
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D016572:Cyclosporine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D016572:Cyclosporine