Performance evaluation of hydroxylated and acylated silicone rubber coatings.
Hydroxylated and C16 acylated silicone rubber films were prepared with enhanced albumin binding. Lee-White clotting times were significantly increased for both treatments. Hydroxylation significantly reduced C5a production. Hydroxylated silicone rubber femoral vein catheters in canines reduced 111In-labeled platelet activity, compared with bilateral silicone rubber catheter controls. The results suggest hydroxylated silicone rubber films have enhanced biocompatibility.
Tsai
C C
CC
Bioengineering Program, University of Texas Southwestern Medical Center, Dallas 75235-9031.
Dollar
M L
ML
Constantinescu
A
A
Kulkarni
P V
PV
Eberhart
R C
RC
D000818:Animals; D001672:Biocompatible Materials; D001777:Blood Coagulation; D001807:Blood Vessel Prosthesis; D003167:Complement Activation; D004285:Dogs; D006801:Humans; D010974:Platelet Aggregation; D011108:Polymers; D012826:Silicone Elastomers; D013499:Surface Properties
D001672:Biocompatible Materials; D011108:Polymers; D012826:Silicone Elastomers