title: Differential effects of neonatal testosterone treatment on aggression in two selection lines of mice.
abstract: Selection lines of mice, artificially selected for aggression based upon the attack latency score (ALS), were used. In order to determine the relative contribution of neonatal testosterone (T) in the development of aggression, we vary the plasma-T level in males of both selection lines on the day of birth. At 14 weeks the ALS was measured. Neonatal T treatment results in a reduction of aggression in the long attack latency (LAL) line, whereas aggressive behaviour of the short attack latency (SAL) line is not affected. Both selection lines show reduction in testicular weight, although the total amount of T-producing Leydig cells was not affected. Neonatal T may cause a permanent reduction in aggressive behaviour in in the LAL line only, probably due to differential appearance of critical periods. It is suggested that the difference in aggressive behaviour between SAL and LAL selection lines is due to a prenatally determined difference in neonatal T sensitivity of the brain.
authors.affiliation: University of Groningen, Department of Animal Physiology, Haren, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Compaan
authors.forename: A J
authors.initials: AJ
authors.lastname: de Ruiter
authors.forename: J M
authors.initials: JM
authors.lastname: Koolhaas
authors.forename: G A
authors.initials: GA
authors.lastname: van Oortmerssen
authors.forename: B
authors.initials: B
authors.lastname: Bohus
mesh_terms: D000374:Aggression / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology; D005260:Female; D008297:Male; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011944:Receptors, Androgen / Q000235:genetics / Q000502:physiology; D012641:Selection, Genetic; D012733:Sex Differentiation / Q000235:genetics* / Q000502:physiology*; D012741:Sexual Maturation / Q000235:genetics / Q000502:physiology; D013739:Testosterone / Q000502:physiology*
chemical_list: D011944:Receptors, Androgen; D013739:Testosterone