title: Protective effects of TJ-960 herbal mixture on hippocampal neuron damage induced by cobalt focus in the cerebral cortex of rats.
abstract: In the cobalt focus experimental epilepsy model, severe hippocampal neuron damage occurs with marked EEG changes. The effects of TJ-960, a herbal medicine formulation, were studied on neuron damage in the CA1 area of rat hippocampus. Continuous oral administration of TJ-960 from one month prior to the cobalt application showed almost complete protection against hippocampal neuron damage induced by cobalt application to the cerebral cortex. TJ-960 also completely inhibited the EEG changes as well as the brain edema induced by cobalt application.
authors.affiliation: Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Sugaya
authors.forename: A
authors.initials: A
authors.lastname: Ishige
authors.forename: K
authors.initials: K
authors.lastname: Sekiguchi
authors.forename: T
authors.initials: T
authors.lastname: Yuzurihara
authors.forename: S
authors.initials: S
authors.lastname: Iizuka
authors.forename: A
authors.initials: A
authors.lastname: Sugimoto
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Wakui
authors.forename: K
authors.initials: K
authors.lastname: Ishihara
authors.forename: M
authors.initials: M
authors.lastname: Aburada
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001834:Body Water / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003035:Cobalt; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects*; D011712:Pyramidal Tracts / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; C461321:shosaikoto-go-keishika-shakuyakuto; D003035:Cobalt