Control of experimental autoimmune uveoretinitis by low dose T cell vaccination.
Autoimmune T lymphocytes can be used under appropriate conditions to induce resistance to the specific autoimmune disease that they usually produce. This practice, termed T cell vaccination, was found to be effective with the injection of a low (subpathogenic) number of autoaggressive T line lymphocytes. We report here that T cell vaccination produced marked resistance to the expression of experimental autoimmune uveoretinitis (EAU) in Lewis rats. In addition, vaccination led to the appearance of lymphoid cells in the vaccinated rats that demonstrated proliferative responses against idiotypic and ergotypic specificities of the injected T cells. This is the first report demonstrating the effector T lymphocytes specific for ocular antigens may be used as agents to modulate immunopathogenic responses responsible for EAU.
Beraud
E
E
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892.
Kotake
S
S
Caspi
R R
RR
Oddo
S M
SM
Chan
C C
CC
Gery
I
I
Nussenblatt
R B
RB
D000595:Amino Acid Sequence; D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D019393:Arrestin; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D002455:Cell Division / Q000276:immunology; D005123:Eye / Q000473:pathology; D005136:Eye Proteins; D005260:Female; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008969:Molecular Sequence Data; D051381:Rats; D012173:Retinitis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D012177:Retinol-Binding Proteins; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D014605:Uveitis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D014611:Vaccination; D000099214:Retinol-Binding Proteins, Interstitial
D000941:Antigens; D019393:Arrestin; D005136:Eye Proteins; D012177:Retinol-Binding Proteins; D000099214:Retinol-Binding Proteins, Interstitial