Increased cerebrospinal fluid cyclo(His-Pro) content in schizophrenia.
Cyclo(His-Pro) (CHP) is a peptide endogenous to human brain and cerebrospinal fluid (CSF). In animal studies administration of exogenous CHP augments dopaminergic neurotransmission. To explore the role of this peptide in schizophrenia, a disease characterized by a hyperdopaminergic state, we have measured CSF CHP levels in control, never-medicated schizophrenics and medicated schizophrenics. Our data show a 53% increase in CSF levels of CHP in never-medicated schizophrenics (p = 0.015), and a 25% increase in medicated schizophrenics when compared to controls. We speculate that CHP may contribute to the expression of hyperdopaminergic symptoms in schizophrenia.
Prasad
C
C
Department of Medicine, Louisiana State University Medical Center, New Orleans 70112.
Hilton
C W
CW
Lohr
J B
JB
Robertson
H J
HJ
D000328:Adult; D004298:Dopamine / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000134:cerebrospinal fluid*; D010879:Piperazines / Q000134:cerebrospinal fluid*; D012559:Schizophrenia / Q000134:cerebrospinal fluid* / Q000188:drug therapy
D010456:Peptides, Cyclic; D010879:Piperazines; C015924:histidyl-proline diketopiperazine; D004298:Dopamine