A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Current summary of lymphocyte survival study.
A recently developed dose-survival assay in vitro using human G0 T-lymphocytes from peripheral blood was employed to assess possible interindividual variation of cellular radiosensitivity. Currently lymphocytes from a total of 99 atomic bomb survivors were tested and D10, the X-ray dose required to kill 90% of the cells, was calculated for each test. The mean +/- SD of D10 value was 3.35 +/- 0.22 Gy for 61 survivors whose DS86 dose is below 0.004 Gy and for 38 survivors of DS86 dose above 1.5 Gy it was 3.31 +/- 0.26 Gy. So far, the results do not show any evidence in support of the hypothesis of a selective elimination of a radiosensitive subcohort among the survivors exposed to high doses.
Nakamura
N
N
Department of Radiobiology, Radiation Effects Research Foundation, Hiroshima, Japan.
Akiyama
M
M
Kyoizumi
S
S
Kusunoki
Y
Y
D002470:Cell Survival / Q000528:radiation effects; D006801:Humans; D007564:Japan; D008214:Lymphocytes / Q000528:radiation effects*; D009689:Nuclear Warfare; D011836:Radiation Tolerance; D013534:Survival