Memory storage and effect of repeated treatment with a new antidepressant drug: rubidium chloride.
Following 15 days' treatment with saline, 48 mg/kg rubidium chloride, 5 mg/kg imipramine hydrochloride, 10 mg/kg sodium phenobarbitone, 1000 mg/kg piracetam, or 0.20 mg/kg strychnine nitrate all administered intraperitoneally, mice were evaluated by habituation of exploratory activity using an open-field apparatus. In control animals a significant (P less than 0.05) decrease in open-field responses (ambulation, rearing and defaecation) was seen following a 1-day intersession interval and there was no retention of exploratory activity after a 5-day intersession interval. Administration of imipramine or phenobarbitone for 15 days was found to impair retention of memory after 1 day, whereas treatment with rubidium chloride, piracetam, or strychnine for 15 days improve retention after a 5-day intersession interval.
de Angelis
L
L
Institute of Pharmacology, School of Medicine, University of Trieste, Italy.
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology*; D004609:Eliminative Behavior, Animal / Q000187:drug effects; D005260:Female; D007099:Imipramine / Q000008:administration & dosage / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D051379:Mice; D010634:Phenobarbital / Q000008:administration & dosage / Q000494:pharmacology; D010889:Piracetam / Q000008:administration & dosage / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D012413:Rubidium / Q000008:administration & dosage / Q000494:pharmacology*; D013331:Strychnine / Q000008:administration & dosage / Q000494:pharmacology
D000928:Antidepressive Agents; D002712:Chlorides; D013331:Strychnine; D012413:Rubidium; C032710:rubidium chloride; D007099:Imipramine; D010634:Phenobarbital; D010889:Piracetam