title: Antithromboxane drug in the treatment of preeclampsia.
abstract: In this study, we present our initial trials in the treatment of 6 cases of severe preeclampsia with thromboxane synthetase inhibitor (OKY-046). Following the treatment with OKY-046, maternal systolic blood pressure decreased significantly and umbilical artery waveforms were normalized. These data suggest that thromboxane synthetase inhibition might have a beneficial effect on preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Furuhashi
authors.forename: M
authors.initials: M
authors.lastname: Tsujiei
authors.forename: H
authors.initials: H
authors.lastname: Kimura
authors.forename: K
authors.initials: K
authors.lastname: Okamura
authors.forename: A
authors.initials: A
authors.lastname: Yajima
mesh_terms: D000328:Adult; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008689:Methacrylates / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
chemical_list: D008689:Methacrylates; D013930:Thromboxane-A Synthase; C034364:ozagrel