[The effect of various non-ulcer pharmaceuticals on nocturnal gastric pH in healthy subjects].
The effects of 4 non-ulcer drugs and the M1-antagonist pirenzepine on the nocturnal intragastric pH were investigated in 12 healthy volunteers. We tested single doses of pirenzepine (100 mg), Chlorprothixene (30 mg), clonidine (75 micrograms), ketotifen (3 mg) and nifedipine (30 mg) in an randomized, single-blind, cross-over study. The nocturnal intraluminal pH is significantly elevated not only by pirenzepine but also by the other substances. As expected pirenzepine (mean nocturnal pH = 2.49 +/- 0.22) shows the most distinct effect, nifedipine (mean nocturnal pH = 1.72 +/- 0.20) the most sparsely effect. The other drugs are nearly half as effective as pirenzepine. The acid suppressive side effect of the non-ulcer remedies is considered to be important for the treatment of ulcer patients with concomitant diseases.
Strohbach
C
C
Klinik für Innere Medizin, Medizinischen Adademie, Carl Gustav Carus, Dresden, Bundesrepublik, Deutschland.
Grammatté
T
T
Schentke
K U
KU
D000328:Adult; D002749:Chlorprothixene / Q000494:pharmacology; D002940:Circadian Rhythm; D003000:Clonidine / Q000494:pharmacology; D005260:Female; D005750:Gastric Juice / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007665:Ketotifen / Q000494:pharmacology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D010890:Pirenzepine / Q000494:pharmacology; D016037:Single-Blind Method; D013268:Stimulation, Chemical
D010890:Pirenzepine; D002749:Chlorprothixene; D009543:Nifedipine; D003000:Clonidine; D007665:Ketotifen
Die Wirkung verschiedener Nichtulkuspharmaka auf den nächtlichen Magen-pH gesunder Probanden.