Survival and synapse formation of transplanted rat rods.
Isolated rods enzymatically removed from normal adult rat retina have been transplanted to the subretinal space of adult rats with a retinal dystrophy which has destroyed almost all the photoreceptors. These transplanted rods survive for months after transplantation during which time they form synapses with other retinal cells. Rod spherules with large amounts of synaptic vesicles and synaptic ribbons are found forming discreet contacts with pre- and post-synaptic densities in arrangements closely resembling those seen in the normal retina.
Gouras
P
P
Department of Ophthalmology, Columbia University, New York, NY 10032.
Du
J
J
Gelanze
M
M
Lopez
R
R
Kwun
R
R
Kjeldbye
H
H
Krebs
W
W
D000818:Animals; D004847:Epithelial Cells; D004848:Epithelium / Q000033:anatomy & histology; D006085:Graft Survival / Q000502:physiology*; D008854:Microscopy, Electron; D010786:Photoreceptor Cells / Q000166:cytology / Q000502:physiology / Q000637:transplantation*; D010858:Pigmentation; D051381:Rats; D012160:Retina / Q000166:cytology; D013569:Synapses / Q000502:physiology*