title: Protective effect of cyproheptadine in a gerbil model of cerebral ischemia.
abstract: The efficacy of Cyproheptadine, a serotonin antagonist, in preventing the cerebral ischemic damage was tested on experimental model of transient global cerebral ischemia in Mongolian Gerbil. The semi-quantitative histological evaluation of the severity of ischemic damage showed a protective effect of Cyproheptadine, mainly in the anterior cortical areas.
authors.affiliation: Clinica Neurologica dell'Università di Genova.
authors.forename: C
authors.initials: C
authors.lastname: Caponnetto
authors.forename: M
authors.initials: M
authors.lastname: Del Sette
authors.forename: M
authors.initials: M
authors.lastname: Furlan
authors.forename: C
authors.initials: C
authors.lastname: Gandolfo
authors.forename: G L
authors.initials: GL
authors.lastname: Mancardi
authors.forename: A
authors.initials: A
authors.lastname: Schenone
authors.forename: C
authors.initials: C
authors.lastname: Loeb
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D003533:Cyproheptadine / Q000627:therapeutic use*; D005260:Female; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000517:prevention & control*; D012701:Serotonin / Q000502:physiology
chemical_list: D003533:Cyproheptadine; D012701:Serotonin