Intrauterine insemination outperforms intracervical insemination in a randomized, controlled study with frozen, donor semen.
OBJECTIVE
To assess the efficacy of intrauterine insemination (IUI) in a donor insemination program.


METHODS
Prospective randomized clinical trial.


METHODS
Donor insemination program.


METHODS
Women undergoing insemination were randomly assigned to receive either IUI or intracervical insemination for a maximum of six cycles.


METHODS
None.


METHODS
Cycle fecundity rates between the two routes were compared.


RESULTS
The monthly fecundity rate for intracervical insemination was 5.1% compared with 23% by IUI. By life table analysis, pregnancy rates for IUI were significantly higher than intracervical insemination (P = 0.02).


CONCLUSIONS
Intrauterine insemination with quarantined donor sperm is superior to intracervical insemination.
Patton
P E
PE
Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland.
Burry
K A
KA
Thurmond
A
A
Novy
M J
MJ
Wolf
D P
DP
D002584:Cervix Uteri; D005260:Female; D005615:Freezing; D006801:Humans; D007316:Insemination, Artificial, Heterologous / Q000379:methods*; D015993:Life Tables; D008297:Male; D008597:Menstrual Cycle; D009845:Oligospermia; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012661:Semen; D014599:Uterus