Oncofetal antigen expression in head and neck carcinoma.
Oncofetal antigens (OFA) are proteins expressed during periods of embryonal/fetal development and on malignant cells. Previous investigations detected the presence of phase-specific 44- and 200-kd OFA, using a monoclonal antibody (MoAb 115). This study will determine if primary head and neck squamous cell carcinomas express the 44-kd OFA, and will assess the possible role of OFA in oncogenesis. Fifteen primary human head and neck squamous cell carcinomas (HNSCC) and six HNSCC cell lines were tested for OFA expression. Thirteen primary cancers and three cell lines demonstrated various degrees of OFA positivity. Oncofetal antigens are proposed to represent a proto-oncogene active during fetal development and malignant growth in head and neck squamous cell carcinomas.
Gussack
G S
GS
Division of Otolaryngology, Emory University School of Medicine, Atlanta, GA.
D000951:Antigens, Neoplasm / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000276:immunology* / Q000648:ultrastructure; D002460:Cell Line; D002469:Cell Separation; D004273:DNA, Neoplasm / Q000032:analysis; D005434:Flow Cytometry; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000276:immunology* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D000090063:Proto-Oncogene Mas; D014407:Tumor Cells, Cultured / Q000276:immunology
D000951:Antigens, Neoplasm; D004273:DNA, Neoplasm; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; C031192:oncofetal antigens