title: Lesions simulating retinoblastoma.
abstract: Of 500 consecutive patients referred to the Ocular Oncology Service at Wills Eye Hospital with the diagnosis of possible retinoblastoma, 288 (58%) were found on clinical evaluation to have retinoblastoma and 212 (42%) had lesions that simulated retinoblastoma. A total of 23 different conditions accounted for the 212 pseudoretinoblastomas. Three most common pseudoretinoblastomas were: persistent hyperplastic primary vitreous (28%), Coats' disease (16%), and presumed ocular toxocariasis (16%). Congenital cataract and retinopathy of prematurity accounted for a much lower percent of pseudoretinoblastomas in this series as compared to a previously reported series. The pertinent clinical features that serve to differentiate these simulating lesions from retinoblastoma are reviewed.
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107.
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: H M
authors.initials: HM
authors.lastname: Parsons
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: P
authors.initials: P
authors.lastname: Shah
mesh_terms: D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis*; D006801:Humans; D012164:Retinal Diseases / Q000175:diagnosis; D012175:Retinoblastoma / Q000175:diagnosis*