Subjective feelings and changes in body sway following diazepam in sons of alcoholics and control subjects.
The possible generalization to diazepam of the dampened response to ethanol in sons of alcoholic fathers was evaluated in 62 sons of alcoholics (family history positive [FHP] subjects) and 62 family history negative (FHN) controls (124 men). Following challenges with placebo, .12 and .2 mg/kg of diazepam in three separate sessions, evaluation of subjective feelings and increases in body sway revealed no decreased reaction for FHPs.
Schuckit
M A
MA
Alcohol Research Center, Veterans Affairs Medical Center, San Diego, California 92161.
Duthie
L A
LA
Mahler
H I
HI
Irwin
M
M
Monteiro
M G
MG
D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology*; D000437:Alcoholism / Q000235:genetics* / Q000523:psychology*; D016241:Child of Impaired Parents / Q000523:psychology*; D003975:Diazepam / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D008297:Male; D004856:Postural Balance / Q000187:drug effects*
D000431:Ethanol; D003975:Diazepam