[Recent findings on the phenotype and function of T-lymphocytes in the human colostrum].
Recent studies in our laboratory have demonstrated that the great majority of human colostral T cells display the phenotypic and functional characteristics of memory T lymphocytes, e.g. were able to proliferate in response to anti-CD3 and anti-CD2 monoclonal antibodies, and to a lesser extent, to the lectin mitogen phytohaemagglutinin. In addition, their production of interferon-gamma after anti-CD3 and anti-CD2 stimuli was similar to that calculated in autologous blood lymphocyte cultures. More interestingly, the proportion of T lymphocytes bearing the gamma/delta T-cell receptor was found to be significantly higher in the mammary secretion than in autologous and heterologous blood samples. Furthermore, these cells were mostly delta-TCS-1+, thereby suggesting that they are actively motile cells capable of migrating from lymphoid to extra-lymphoid body tissues. The fact that the phenotypic pattern of colostral gamma/delta T cells is similar, if not identical, to that of the intestinal intraepithelial counterpart suggests that these cells might originate in the gut-associated lymphoid system and home selectively to the mammary gland late in pregnancy and throughout lactation. However, additional studies are needed to confirm whether milk T lymphocytes are actively involved in the adoptive lactation transmission of cellular immunity to the suckling infant.
Bertotto
A
A
Istituto di Clinica Pediatrica, Università degli Studi di Perugia, Italia.
Castellucci
G
G
Scalise
F
F
Vaccaro
R
R
D003126:Colostrum / Q000166:cytology / Q000276:immunology*; D005260:Female; D006801:Humans; D010641:Phenotype; D011247:Pregnancy; D013601:T-Lymphocytes / Q000502:physiology*
Recenti acquisizioni sul fenotipo e la funzione dei T linfociti presenti nel colostro umano.