title: Streptococcus associated toxic shock.
abstract: In the past few years, there appears to have been a change in the spectrum of disease caused by group A beta-haemolytic streptococcus (GABHS), and a toxic shock-like syndrome caused by this organism has recently been described in adults. We report four children with an acute illness characterised by rapid progression of shock, erythematous rash, multisystem organ involvement, electrolyte derangements, and desquamation who fulfil the previously established diagnostic criteria for toxic shock syndrome. Three of the children had extensive cutaneous and soft tissue infection and the fourth had peritonitis. All four developed bacteraemia. Treatment included aggressive cardiovascular resuscitation and antibiotic therapy. Although no patient died, they suffered multiple and severe complications requiring prolonged treatment and hospitalisation. Streptococcal toxic shock syndrome is a separate and clearly defined entity occurring in previously healthy children.
authors.affiliation: Academic Department of Paediatrics, St Mary's Hospital Medical School, London.
authors.forename: C
authors.initials: C
authors.lastname: Torres-Martínez
authors.forename: D
authors.initials: D
authors.lastname: Mehta
authors.forename: A
authors.initials: A
authors.lastname: Butt
authors.forename: M
authors.initials: M
authors.lastname: Levin
mesh_terms: D016887:Cardiopulmonary Resuscitation; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010406:Penicillins / Q000627:therapeutic use; D012772:Shock, Septic / Q000209:etiology* / Q000628:therapy; D013290:Streptococcal Infections / Q000150:complications*; D013297:Streptococcus pyogenes
chemical_list: D010406:Penicillins