title: The effect of a low-osmolar radiographic contrast medium on in vivo and postmortem renal size.
abstract: High osmolar radiographic contrast media (CM) are known to cause an increase in renal size. To examine the effect of low-osmolar CM on renal size, 14 anesthetized dogs received 12 intravenous bolus injections of 0.5 mL/kg iohexol (541 mOsm/L). The postmortem renal, cortical, and medullary volumes were determined by fluid displacement. Renal volumes of 18 control dogs were determined similarly. The mean (+/- SEM) postmortem renal volumes were 66.1 +/- 2.2 mL for the CM group and 52.3 +/- 3.3 mL for the control group (P = 0.003), whereas the cortical and medullary volumes were similar. Six dogs were also scanned by fast computerized tomography before and after iohexol administration. The in vivo whole renal and medullary volumes enlarged from 67.4 +/- 3.0 to 77.1 +/- 2.8 mL (P = 0.006), and from 28.5 +/- 2.0 to 35.1 +/- 1.1 mL (P = 0.026), respectively, while the cortical volume remained unaltered. These results suggest that even low osmolar CM may significantly increase renal volume, probably by causing tubular expansion.
authors.affiliation: Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: L O
authors.initials: LO
authors.lastname: Lerman
authors.forename: M D
authors.initials: MD
authors.lastname: Bentley
authors.forename: M R
authors.initials: MR
authors.lastname: Bell
authors.forename: J A
authors.initials: JA
authors.lastname: Rumberger
authors.forename: P F
authors.initials: PF
authors.lastname: Sheedy
authors.forename: J C
authors.initials: JC
authors.lastname: Romero
mesh_terms: D000818:Animals; D004285:Dogs; D007472:Iohexol / Q000008:administration & dosage / Q000009:adverse effects*; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D014057:Tomography, X-Ray Computed
chemical_list: D007472:Iohexol