title: Involvement of nicotinic receptors in the dorsal motor nucleus of the vagus in regulation of gastric motility in rats.
abstract: Roles of nicotinic receptors in the dorsal motor nucleus of the vagus (DMV) in the regulation of gastric motility were investigated in urethane-anesthetized rats in which an intragastric balloon had been placed. Nicotine (0.1 nmole) microinjected into the DMV but not the nucleus ambiguus induced dual changes, a decrease followed by an increase in gastric motility. Administration of 0.1 nmole of hexamethonium into the DMV significantly inhibited the decrease in gastric motility induced by intravenously administered nicotine.
authors.affiliation: Department of Pharmacology, Kochi Medical School, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: Y
authors.initials: Y
authors.lastname: Osumi
mesh_terms: D000818:Animals; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology*; D009538:Nicotine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000502:physiology*; D014630:Vagus Nerve
chemical_list: D011978:Receptors, Nicotinic; D009538:Nicotine