Liver transplantation for chronic viral hepatitis.
Liver transplantation remains a problem for end stage liver disease due to chronic viral hepatitis, in contrast to the success with fulminant hepatitis B, D and C in which recurrence of viraemia is relatively rare. Following transplantation for chronic HCV disease recurrence of hepatitis C is infrequent and does not appear to be an important clinical problem. The complete picture will only be described when a suitable HCV-RNA test becomes routinely available. Patients with cirrhosis due to hepatitis B, with low levels of viraemia, or patients with hepatitis D are less likely to develop reinfection than those with high levels of HBV viraemia. The use of hepatitis B immunoglobulin in high doses for prolonged periods delays rather than prevents recurrence. It is a very expensive ancillary treatment. Patients with chronic hepatitis D related cirrhosis in whom levels of hepatitis B replication are suppressed, have a low recurrence rate even without immunoglobulin prophylaxis although HDAg remains in the liver. Hepatitis only reoccurs with recurrence of HBV infection. Unfortunately transplantation of HBV DNA and HBeAg positive patients has many shortcomings, and reinfection of the engrafted liver and subsequent development of hepatitis B is common. Survival rates are reduced in this latter group. At present there are no firm recommendations that can be given to prevent recurrence: HBIG in large doses and for prolonged periods would appear to be insufficient to prevent reinfection and these patients often die of recurrent disease. A major challenge for transplant groups will be the prevention of viral reinfection particularly in this latter group.(ABSTRACT TRUNCATED AT 250 WORDS)
Belli
L
L
Hepatobiliary Unit, Royal Free Hospital, School of Medicine, Hampstead, London, UK.
Dusheiko
G
G
Rolles
K
K
Burroughs
A K
AK
D002908:Chronic Disease; D006509:Hepatitis B / Q000601:surgery; D006526:Hepatitis C / Q000601:surgery; D003699:Hepatitis D / Q000601:surgery; D006525:Hepatitis, Viral, Human / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D012008:Recurrence; D015996:Survival Rate; D016896:Treatment Outcome