[Suppression of translation in vitro of the mRNA of the M1 protein of influenza virus using antisense oligonucleotides].
Effect of antisense oligonucleotides on the in vitro translation of the influenza virus M1 protein mRNA was investigated. The most efficient arrest of mRNA translation was achieved by simultaneous action of two or three oligonucleotides (14-16-mers) complementary to the juxtaposed sequences in the 5'-terminus of the molecule around and upstream of the initiation codon.
Vlasov
V V
VV
Gorn
V V
VV
Nomokonova
N Iu
NIu
Fokina
T N
TN
Iurchenko
L V
LV
D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D004591:Electrophoresis, Polyacrylamide Gel; D009980:Influenza A virus / Q000378:metabolism; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D014176:Protein Biosynthesis / Q000187:drug effects*; D012333:RNA, Messenger / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*; D011817:Rabbits; D014763:Viral Matrix Proteins / Q000235:genetics*
C031540:M-protein, influenza virus; C488936:M1 protein, Influenza A virus; D016376:Oligonucleotides, Antisense; D012333:RNA, Messenger; D012367:RNA, Viral; D014763:Viral Matrix Proteins
Podavlenie transliatsii in vitro mRNK belka M1 virusa grippa s pomoshch'iu antismyslovykh oligonukleotidov.