Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.
O'Dwyer
P J
PJ
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.
Hamilton
T C
TC
Young
R C
RC
LaCreta
F P
FP
Carp
N
N
Tew
K D
KD
Padavic
K
K
Comis
R L
RL
Ozols
R F
RF
D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019328:Buthionine Sulfoximine; D005260:Female; D005978:Glutathione / Q000187:drug effects*; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008717:Methionine Sulfoximine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
D000964:Antimetabolites, Antineoplastic; D008717:Methionine Sulfoximine; D019328:Buthionine Sulfoximine; D005978:Glutathione; D008558:Melphalan