Purine metabolites and pyrimidine bases in cerebrospinal fluid of children with simple febrile seizures.
Adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine, uric acid and pyrimidine bases were determined in the CSF of 18 children after simple febrile seizures and in a control group. There was no statistically significant difference between the two groups for any of these metabolites. This suggests that simple febrile seizures neither significantly disturb the metabolism of nucleotides, nucleosides or bases, nor significantly deplete neuron adenosine triphosphate ATP levels.
Rodríguez-Núñez
A
A
Departamento de Pediatria, Hospital General de Galician, Clínico Universitario, Santiago de Compostela, Spain.
Camiña
F
F
Lojo
S
S
Rodríguez-Segade
S
S
Castro-Gago
M
M
D000225:Adenine / Q000134:cerebrospinal fluid; D000241:Adenosine / Q000134:cerebrospinal fluid; D000249:Adenosine Monophosphate / Q000134:cerebrospinal fluid; D002675:Child, Preschool; D003596:Cytosine / Q000134:cerebrospinal fluid; D005260:Female; D006147:Guanine / Q000134:cerebrospinal fluid; D006151:Guanosine / Q000134:cerebrospinal fluid; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000134:cerebrospinal fluid; D007223:Infant; D007288:Inosine / Q000134:cerebrospinal fluid; D007291:Inosine Monophosphate / Q000134:cerebrospinal fluid; D008297:Male; D011687:Purines / Q000134:cerebrospinal fluid*; D011741:Pyrimidine Nucleosides / Q000134:cerebrospinal fluid*; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid*; D013941:Thymine / Q000134:cerebrospinal fluid; D014498:Uracil / Q000134:cerebrospinal fluid; D014527:Uric Acid / Q000134:cerebrospinal fluid; D019820:Xanthine; D014970:Xanthines / Q000134:cerebrospinal fluid
D007042:Hypoxanthines; D011687:Purines; D011741:Pyrimidine Nucleosides; D014970:Xanthines; D006151:Guanosine; D007291:Inosine Monophosphate; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D000249:Adenosine Monophosphate; D014498:Uracil; D007288:Inosine; D006147:Guanine; D003596:Cytosine; D000225:Adenine; D000241:Adenosine; D013941:Thymine