title: The effect of short-term growth hormone or low-dose oxandrolone treatment in boys with constitutional growth delay.
abstract: We evaluated the effect of six-month treatment with growth hormone (GH) or low-dose oxandrolone in a group of boys with constitutional growth delay (CGD). Sixteen boys were randomly assigned to two treatment groups. Group 1 received GH (0.6 U/kg/week sc 5-6 times/week) and Group 2 received oxandrolone (0.07 mg/kg po). The boys of the two groups were closely matched for age (13.7 +/- 0.5 and 12.8 +/- 0.4 years) (mean +/- SE), chronologic age/bone age ratio (1.15 +/- 0.04 and 1.16 +/- 0.02), height standard deviation score (SDS; -2.7 +/- 0.4 and -2.5 +/- 0.3) and pretreatment height velocity (HV) (3.7 +/- 0.8 and 4.0 +/- 0.4 cm/year). Other known causes of short stature were excluded in all subjects, and none had taken long-term medication prior to the study. After 6 months of treatment HV increased to 7.5 +/- 0.4 and to 8.1 +/- 0.5 cm/year in group 1 and 2, respectively. Plasma IGF-I concentrations rose significantly after treatment in both groups. Predicted adult height was not significantly affected by either GH or oxandrolone treatment. We conclude that a short-term course of low-dose oxandrolone is as effective as GH to accelerate growth in boys with CGD. Low-dose oxandrolone represents an effective, cheap, and convenient therapeutic approach in boys with CGD.
authors.affiliation: Istituto di Clinica Pediatrica, Università di Cagliari, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Loche
authors.forename: C
authors.initials: C
authors.lastname: Pintor
authors.forename: P
authors.initials: P
authors.lastname: Cambiaso
authors.forename: A
authors.initials: A
authors.lastname: Lampis
authors.forename: D
authors.initials: D
authors.lastname: Carta
authors.forename: R
authors.initials: R
authors.lastname: Corda
authors.forename: M
authors.initials: M
authors.lastname: Cappa
mesh_terms: D000293:Adolescent; D001827:Body Height; D002648:Child; D006130:Growth Disorders / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013006:Growth Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D010074:Oxandrolone / Q000008:administration & dosage / Q000627:therapeutic use*; D013737:Testis / Q000254:growth & development
chemical_list: D007334:Insulin-Like Growth Factor I; D010074:Oxandrolone; D013006:Growth Hormone