title: Chromosomal abnormalities in childhood acute nonlymphocytic leukemia (M4).
abstract: A new reciprocal, apparently balanced translocation between chromosomes 7 and 22, i.e., t(7;22)(p22;q13), in association with inv(16)(p13q22) in a child with acute nonlymphocytic leukemia (M4) is reported. Five percent of her bone marrow cells contained both of these aberrations while 90% of her cells have the pericentric inversion of chromosome 16 as the sole abnormality. A clonal evolution of the unusual cell line may be associated with atypical clinical presentation. The presence of inversion 16 in adults has a better prognosis as compared with children. A concise review on the cytogenetic findings in children with ANLL(M4) is also provided.
authors.affiliation: Hamad Medical Corporation, Doha, Qatar.
authors.forename: S H
authors.initials: SH
authors.lastname: Mostafavipour
authors.forename: M
authors.initials: M
authors.lastname: Abulaban
authors.forename: K
authors.initials: K
authors.lastname: Alali
authors.forename: A
authors.initials: A
authors.lastname: al Zaman
authors.forename: M J
authors.initials: MJ
authors.lastname: Macera
authors.forename: R S
authors.initials: RS
authors.lastname: Verma
mesh_terms: D002648:Child; D002869:Chromosome Aberrations / Q000473:pathology; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D014178:Translocation, Genetic