Comparative efficacies of amphotericin B lipid complex and amphotericin B deoxycholate suspension against murine blastomycosis.
Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P less than 0.05 to 0.001). Fungizone was more effective than lipid complex at doses of 0.8 mg/kg of body weight. However, lipid complex at 12.8 mg/kg was not toxic and superior in efficacy (P less than 0.001) to 2.0 mg of Fungizone per kg (a toxic dose), and it cleared all animals of infection. Lipid complex is an effective therapy for murine blastomycosis.
Clemons
K V
KV
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
Stevens
D A
DA
D000666:Amphotericin B / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001758:Blastomyces / Q000187:drug effects; D001759:Blastomycosis / Q000188:drug therapy* / Q000382:microbiology; D003840:Deoxycholic Acid / Q000737:chemistry; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D008168:Lung / Q000382:microbiology; D008172:Lung Diseases, Fungal / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008823:Micelles; D008826:Microbial Sensitivity Tests; D010715:Phosphatidylglycerols / Q000737:chemistry; D013535:Suspensions
D008823:Micelles; D010715:Phosphatidylglycerols; D013535:Suspensions; D003840:Deoxycholic Acid; D000666:Amphotericin B; C002773:dimyristoylphosphatidylglycerol; D004134:Dimyristoylphosphatidylcholine