Significance of chromosomal abnormalities in a malignant giant cell tumor of bone.
Cytogenetic analysis of a malignant giant cell tumor of the sacrum from a 62-year-old female revealed the following chromosomal complement: 47,XX, -1, -11, +22,del(2)(p22),t(7;7) (p22;q32), +der(1)t(1;11;21)(p32;q13;q22), +der(19)t(19;?)(q13.4;?), der(8)t(8;?)(p11;?), der(7)t(17;?)(p13;?). Metaphase cells with 92-127 chromosomes sharing identical structural abnormalities detected in the near-diploid cells were also observed. Several of these abnormalities have previously been described in the benign giant cell tumors supporting a direct relationship between these benign and malignant neoplastic counterparts.
Bridge
J A
JA
Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City.
Mouron
B J
BJ
Neff
J R
JR
Bhatia
P S
PS
D001859:Bone Neoplasms / Q000473:pathology*; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D005260:Female; D005870:Giant Cell Tumors / Q000473:pathology*; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D012447:Sacrum