title: [Value of a new fast CK-MB determination for the diagnosis of myocardial infarction during the 1st hours. Preliminary study].
abstract: This study evaluated the time for a new, rapid and reliable CK-MB analysis to become positive in myocardial infarction and compared it with classical total CK analyses. Serial analyses of total CK and CK-MB were performed in 49 consecutive patients referred to the Coronary Care Unit for suspected acute myocardial infarction. Twenty of these patients had myocardial infarction with rising enzyme levels, which enabled comparison of the precocity of one analysis compared to another. In these patients, the CK-MB analysis became positive on average 85 to 110 minutes before that of total CK. This result shows that CK-MB analysis can be a diagnostic sign of acute myocardial infarction at an earlier stage than the total CK analysis. The authors discuss the clinical value of this test in difficult indications of fibrinolytic therapy and underline that it enables a more objective assessment of the time of onset of necrosis than clinical data alone.
authors.affiliation: Unité 60, hôpital cardiologique, Lyon.
authors.forename: F
authors.initials: F
authors.lastname: Gueyffier
authors.forename: M
authors.initials: M
authors.lastname: Gallet
authors.forename: P
authors.initials: P
authors.lastname: Chapon
authors.forename: H
authors.initials: H
authors.lastname: Coquelin
mesh_terms: D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000097:blood* / Q000201:enzymology / Q000628:therapy; D011237:Predictive Value of Tests; D015912:Thrombolytic Therapy
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase
vernacular_title: Intérêt d'un nouveau dosage rapide de la CK-MB pour le diagnostic de l'infarctus du myocarde dans les premières heures. Etude préliminaire.