Doxorubicine englobed in polybutylcyanoacrylate nanocapsules: behaviour in vitro and in vivo.
Nanocapsules of polybutylcyanoacrylate containing doxorubicine were prepared from w/o microemulsion. A concentration of about 10% of the drug was obtained. After washing, dispersion and lyophilization of the nanocapsules, some experiments were performed in vivo and in vitro. About 1% of doxorubicine was released in vitro in 48 hours; after injection on the hairless back of rabbits, the nanoparticles without the drug gave any inflammatory processes, while the nanocapsules containing doxorubicine gave a deeper and more prolonged ulcer than that of the same amount of doxorubicine in solution, indicating that practically all the drug was inside the nanocapsules.
Gasco
M R
MR
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino.
Morel
S
S
Trotta
M
M
Viano
I
I
D000818:Animals; D002214:Capsules; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004659:Enbucrilate; D007279:Injections, Subcutaneous; D011817:Rabbits; D013535:Suspensions
D002214:Capsules; D013535:Suspensions; D004317:Doxorubicin; D004659:Enbucrilate