title: Treatment of unruptured tubal pregnancy by local injection of methotrexate and prostaglandin F2 alpha in 52 patients.
abstract: Uncomplicated tubal pregnancies were treated by local injection of methotrexate (25 to 50 mg) and PGF2 alpha (5 to 10 mg). Trophoblastic resorption occurred in 50 (96.1%) of 52 patients within 20 days after treatment and without side effects. Three months after treatment, the affected tube was patent in 43 (91.4%) of 47 patients continuing in the study, and the subsequent intrauterine pregnancy rate was 40.4%. The combined use of methotrexate and PGF2 alpha appears to be a promising treatment for tubal pregnancy and should be evaluated further.
authors.affiliation: First Obstetrical and Gynecological Department, Elena Venizelou Obstetrical and Gynecological Hospital, Athens, Greece.
authors.forename: C A
authors.initials: CA
authors.lastname: Lappas
authors.forename: G G
authors.initials: GG
authors.lastname: Giannakodimos
mesh_terms: D015237:Dinoprost / Q000008:administration & dosage* / Q000627:therapeutic use; D020964:Embryo Loss; D005186:Fallopian Tube Patency Tests; D005187:Fallopian Tubes / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000628:therapy*
chemical_list: D015237:Dinoprost; D008727:Methotrexate