title: Cerebral infarction associated with protein C deficiency following allogeneic bone marrow transplantation.
abstract: Hypercoagulable states associated with deficiencies in circulating anticoagulant protein C occur after chemotherapy for a variety of malignant diseases. Protein C deficiency also occurs following bone marrow transplantation (BMT) and may be responsible for a variety of transplantation-associated complications. We report the case of a child who suffered a stroke associated with low protein C antigen and activity occurring 11 months after allogeneic BMT. Protein C levels recovered spontaneously by 18 months after BMT. We speculate that the protein C deficiency and and resultant hypercoagulable state led to the stroke, and the deficiency of this anticoagulant was a sequela of the transplant.
authors.affiliation: Section of Pediatric Hematology/Oncology and Bone Marrow Transplantation, University of Nebraska Medical Center, Omaha 68195-2165.
authors.forename: B G
authors.initials: BG
authors.lastname: Gordon
authors.forename: K L
authors.initials: KL
authors.lastname: Saving
authors.forename: J A
authors.initials: JA
authors.lastname: McCallister
authors.forename: P I
authors.initials: PI
authors.lastname: Warkentin
authors.forename: J R
authors.initials: JR
authors.lastname: McConnell
authors.forename: W M
authors.initials: WM
authors.lastname: Roberts
authors.forename: P F
authors.initials: PF
authors.lastname: Coccia
authors.forename: W D
authors.initials: WD
authors.lastname: Haire
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002544:Cerebral Infarction / Q000209:etiology*; D002648:Child; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000601:surgery; D020151:Protein C Deficiency; D014184:Transplantation, Homologous