title: An evaluation of some leukocytary phenotypes in subjects with evolutive primary coxarthrosis and in subjects with hip prostheses.
abstract: The authors examined 52 patients (36 females and 16 males) of whom 15 affected with evolutive primary coxarthrosis, 27 with hip prostheses for 4 to 13 years, and 10 with a prosthetic implant which was not tolerated. A method of indirect immunofluorescence with monoclonal antibodies against specific antigens of the cellular surface was used to typify the T-lymphocytic subpopulations (T-helper/inducer and T-suppressor/cytotoxic), the activated mononucleate cells (DR+), and the B-lymphocytes and monocytes. A good correlation between the imbalances in the T-lymphocytic subpopulations, an increase in the activated mononucleate cells (principally due to T-lymphocytes) and the tolerance of the implant were observed. Based on the results obtained, the authors hypothesize the possibility of using the typing of T-lymphocytes and activated mononucleate cells, together with other biohumoral parameters, as indicators of periprosthetic tissue phologosis.
authors.affiliation: Istituto Ortopedico Rizzoli, Bologna.
authors.forename: R
authors.initials: R
authors.lastname: Manduchi
authors.forename: L
authors.initials: L
authors.lastname: Prosperi
authors.forename: N
authors.initials: N
authors.lastname: Bettini
authors.forename: G
authors.initials: G
authors.lastname: Fontanesi
mesh_terms: D000368:Aged; D005260:Female; D005455:Fluorescent Antibody Technique; D006622:Hip Prosthesis; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000276:immunology*; D010641:Phenotype; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology