title: The early development of palatal rugae in the rat.
abstract: The palatal rugae in rats are contained in two of three zones of morpho-differentiation and develop around the time of palatal closure. Previous studies in humans and pigs have been based on crown-rump lengths but now controlled breeding in rats has allowed exact timing to be established. Twenty-nine female DB IX rats were fertilized and sacrificed in a controlled procedure and foetuses processed for light microscopy and SEM. Serial sagittal sections were made and stained with haematoxylin and eosin and Verhoef's stains. At day 13 the palate was open and no rugae were visible. At day 14 the palatal shelves had started to migrate medially and the ante-molar rugae appeared. At day 15 the palatal shelves were touching and the inter-molar rugae became visible, and at day 16 fusion was all but complete and the definitive rugal pattern established. The development and differentiation is more advanced than in humans and it is concluded that the rugae probably have a role to play in the oral function of animals whereas in humans they are becoming attenuated and the development timetable is retarded because of redundancy.
authors.affiliation: Department of Dental Prosthetics, University of Stellenbosch.
authors.forename: C J
authors.initials: CJ
authors.lastname: Thomas
authors.forename: R J
authors.initials: RJ
authors.lastname: Rossouw
mesh_terms: D000818:Animals; D004847:Epithelial Cells; D004848:Epithelium / Q000196:embryology; D008648:Mesoderm / Q000166:cytology; D010159:Palate / Q000033:anatomy & histology / Q000196:embryology*; D051381:Rats; D011919:Rats, Inbred Strains