[The modifying effect of novocaine on the clinical manifestations of the intestinal form of radiation sickness].
On rats and dogs exposed to absolute lethal doses of X-irradiation (rats--10, 12 Gy; dogs--15 Gy sublethally) it has been shown that novocaini injection to animals immediately after radiation exposure reduces the primary radiation reaction and at the same time shifts the changes in morphofunctional state of peripheric blood on 24 hours, reduces the symptoms of acute radiation sickness, increases the average life length of the animals on 1,5 days. A conclusion concerning the expressed therapeutic influence of intraperitoneal novocaini injection immediately after radiation has been drawn.
Kostesha
N Ia
NIa
Kuptsov
V P
VP
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D007410:Intestinal Diseases / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D008297:Male; D011343:Procaine / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D051381:Rats; D013997:Time Factors; D014916:Whole-Body Irradiation
D011343:Procaine
Modifitsiruiushchee vliianie novokaina na klinicheskie proiavleniia kishechnoĭ formy luchevoĭ bolezni.