title: Multicentric breast tumour: an anatomical-clinical study of 100 cases.
abstract: Multicentric tumours (MT) represent a potential limit to the treatment by conservative surgery of cancer of the breast. In order to determine which anatomical-clinical features of breast cancer would indicate the highest risk of MT, we studied 100 patients with MT and 452 patients with unicentric tumours (UT), all of whom had been subjected to radical mastectomy during the period 1980 to 1988. Statistical analysis showed a significant difference between the two groups of parameters for bilateral breast cancer (with regard both to metachronous and synchronous lesions), for primary tumours of over 2 cm in size, for both lobular and invasive ductal histotypes and for involvement of the nipple-areola complex. Therefore, if the indications in favour of conservative surgery are applied accurately in combination with radiation therapy, the clinical and biological significance of multicentricity is minimized.
authors.affiliation: Istituto di Clinica Chirurgica, Università di Pisa, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Spinelli
authors.forename: P
authors.initials: P
authors.lastname: Berti
authors.forename: E
authors.initials: E
authors.lastname: Ricci
authors.forename: P
authors.initials: P
authors.lastname: Miccoli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015409:Mastectomy, Radical; D008875:Middle Aged