title: Conversion of bromperidol to reduced bromperidol in human liver.
abstract: Bromperidol (BRP) is an analog of haloperidol, a potent butyrophenone neuroleptic. Reductive conversion of BRP carbonyl group to reduced bromperidol (RBRP) was confirmed in vitro using human liver. This NADPH-dependent reduction of BRP showed a similar inhibition pattern and Michaelis constants to haloperidol carbonyl reductase.
authors.affiliation: Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Someya
authors.forename: T
authors.initials: T
authors.lastname: Inaba
authors.forename: R F
authors.initials: RF
authors.lastname: Tyndale
authors.forename: S W
authors.initials: SW
authors.lastname: Tang
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000429:Alcohol Oxidoreductases / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006220:Haloperidol / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D000429:Alcohol Oxidoreductases; D006220:Haloperidol; C006820:bromperidol