title: Mathematical modelling of flow through an irregular arterial stenosis.
abstract: A mathematical model of flow through an irregular arterial stenosis is developed. The model is two-dimensional and axi-symmetric with the stenosis outline obtained from a three-dimensional casting of a mildly stenosed artery. Agreement between modelled and experimental pressure drops (obtained from an axi-symmetric machined stenosis with the same profile) is excellent. Results are also obtained for a smooth stenosis model, similar to that used for most mathematical modelling studies. This model overestimates the pressure drop across the stenosis, as well as the wall shear stress and separation Reynolds number. Also, the smooth model predicts one instead of three recirculation zones present in the irregular model. The original stenosis is modified to increase the severity from 48 and 87% areal occlusion, while maintaining the same general shape. This has the effect of increasing the pressure drop by an order of magnitude and decreasing the number of recirculation zones to one, with a lower separation Reynolds number.
authors.affiliation: Department of Medicine, University of Tasmania, Hobart, Australia.
authors.forename: P R
authors.initials: PR
authors.lastname: Johnston
authors.forename: D
authors.initials: D
authors.lastname: Kilpatrick
mesh_terms: D001157:Arterial Occlusive Diseases / Q000473:pathology / Q000503:physiopathology*; D003251:Constriction, Pathologic / Q000473:pathology / Q000503:physiopathology; D003331:Coronary Vessels; D006801:Humans; D008955:Models, Cardiovascular; D011312:Pressure; D012039:Regional Blood Flow; D012212:Rheology; D013314:Stress, Mechanical