Signaling pathways in odorant detection.
The application of molecular genetic techniques has led to the identification of olfactory-specific proteins that represent each component in a second messenger cascade. Our current understanding of signaling in the olfactory system suggests that receptor proteins of a large family, responsible in part for the specificity of the system, converge on a relatively small number of second messenger systems. The ability to express these elements in heterologous systems should allow for the reconstitution of the signaling cascade and provide insight into the specificity of ligand binding, pathway activation, and signal termination.
Reed
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Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Baltimore, Maryland.
D000818:Animals; D006801:Humans; D009812:Odorants / Q000032:analysis*; D009833:Olfactory Pathways / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*