title: [The efficacy of smectite in acute infantile diarrhea, compared to a placebo and loperamide].
abstract: Fifty-six infants (aged 2 months to two years) with moderate to severe diarrhea were entered in a comparative therapeutic trial of smectite versus placebo or loperamide. Results showed that diarrhea resolved faster under smectite than under placebo and at least as fast under smectite as under loperamide. Tolerance of smectite is excellent as a result of the lack of any effect on intestinal motility.
authors.affiliation: Service de Pédiatrie I, CHU Dupuytren, Limoges.
authors.forename: B
authors.initials: B
authors.lastname: Gilbert
authors.forename: A
authors.initials: A
authors.lastname: Lienhardt
authors.forename: S
authors.initials: S
authors.lastname: Palomera
authors.forename: L
authors.initials: L
authors.lastname: Barberis
authors.forename: D
authors.initials: D
authors.lastname: Borreda
mesh_terms: D003681:Dehydration / Q000517:prevention & control; D003968:Diarrhea, Infantile / Q000188:drug therapy*; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008139:Loperamide / Q000627:therapeutic use*; D008297:Male; D010919:Placebos; D017640:Silicates; D013997:Time Factors; D015431:Weight Loss
chemical_list: D005765:Gastrointestinal Agents; D010919:Placebos; D017640:Silicates; D008139:Loperamide; C033214:Smectite
vernacular_title: Etude de l'efficacité de la smectite dans les diarrhées aiguës du nourrisson, comparativement à un placebo et au lopéramide.