title: Nitrendipine is a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes.
abstract: Nitrendipine, a classical blocker of L-type Ca2+ channels, is shown to be a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na+ and K+ concentrations and in which the channel was activated using the Ca2+ ionophore ionomycin, nitrendipine inhibited K+(86Rb+) influx with an I50 of around 130 nM. Similar results were obtained for K+(86Rb+) efflux, and for K+(86Rb+) influx into cells suspended in a high-K+ medium.
authors.affiliation: University Laboratory of Physiology, University of Oxford, UK.
authors.forename: J C
authors.initials: JC
authors.lastname: Ellory
authors.forename: K
authors.initials: K
authors.lastname: Kirk
authors.forename: S J
authors.initials: SJ
authors.lastname: Culliford
authors.forename: G B
authors.initials: GB
authors.lastname: Nash
authors.forename: J
authors.initials: J
authors.lastname: Stuart
mesh_terms: D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D009568:Nitrendipine / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism*
chemical_list: D015221:Potassium Channels; D009568:Nitrendipine; D002118:Calcium