Pathology of atherosclerosis in cholesterol-fed, susceptible mice.
In recent years the C57BL/6J mouse has gained popularity as a model for studying the genetics of diet-induced atherosclerosis. After 10-20 weeks of consuming a diet enriched with saturated fat and cholesterol, it develops fatty streak-like lesions in the valve sinus region of the ascending aorta. The current study shows that continuing the atherogenic diet for a further 15 weeks leads to the development of fibro-fatty lesions which have many of the characteristics of human atheromatous plaques. This finding lends credence to the use of C57BL/6J mice for studying the pathogenesis of atherosclerosis.
Stewart-Phillips
J L
JL
Montreal General Hospital Research Institute, Quebec, Canada.
Lough
J
J
D000818:Animals; D001011:Aorta / Q000648:ultrastructure*; D001161:Arteriosclerosis / Q000097:blood / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004198:Disease Susceptibility; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D014280:Triglycerides; D002784:Cholesterol