title: [Use of high-dose intravenous immunoglobulins in the therapy of connectivitis: preliminary experience in 5 cases].
abstract: The Authors report their favourable experience concerning the treatment of five cases of connective tissue diseases with high-dose intravenous immunoglobulins: three cases of systemic lupus erythematosus with nephritis, hematological involvement and fever; one case of antiphospholipid antibody-associated pregnancy; and one case of juvenile dermatomyositis. Disease manifestations had proved refractory to previous conventional and sometimes aggressive therapies in all the patients. The results obtained are discussed on the basis of more recent data from the literature. Further investigation in the treatment of connective tissue diseases with intravenous immunoglobulins is suggested. However, this therapy should be employed only in carefully selected patients.
authors.affiliation: Unità operativa di Immunologia clinica, Università, Pisa.
authors.forename: S
authors.initials: S
authors.lastname: De Vita
authors.forename: A
authors.initials: A
authors.lastname: D'Ascanio
authors.forename: S
authors.initials: S
authors.lastname: Bombardieri
mesh_terms: D000293:Adolescent; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000628:therapy; D003240:Connective Tissue Diseases / Q000628:therapy*; D003882:Dermatomyositis / Q000628:therapy; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008180:Lupus Erythematosus, Systemic / Q000628:therapy; D008181:Lupus Nephritis / Q000628:therapy; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy
chemical_list: D016756:Immunoglobulins, Intravenous
vernacular_title: Impiego delle immunoglobuline per via endovenosa ad alte dosi nella terapia delle connettiviti: esperienze preliminari in 5 casi.