Diabetes mellitus in sand rats (Psammomys obesus): microangiopathy during development of the diabetic syndrome.
The purpose of the study was to investigate the development of microangiopathic complications in North African sand rats with diabetes induced by a long-term standard laboratory diet. Hyperinsulinaemic rats, whether non-diabetic obese or diabetic, developed capillary basement membrane (CBM) thickening in the skin; in insulin-dependent animals, this change was diffuse. Many PAS positive areas were demonstrated in skeletal muscle and myocardium, together with evidence of microangiopathy; the primary myocardial lesion in insulin-dependent disease was ischaemic fibrosis. The kidney was also affected with marked basement membrane thickening in Bowman's capsule and glomerular capillaries; glomerulosclerosis and tubular changes were found in insulin-dependent disease. No evidence of diabetic retinopathy was found, and there was a high incidence of cataract.
Marquie
G
G
Centre de Recherches de Physiopathologie expérimentale de la Nutrition, Université P. Sabatier, Toulouse, France.
Duhault
J
J
Hadjiisky
P
P
Petkov
P
P
Bouissou
H
H
D000818:Animals; D001485:Basement Membrane / Q000473:pathology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000662:veterinary*; D003964:Diaphragm / Q000473:pathology; D005260:Female; D005849:Gerbillinae; D007668:Kidney / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D012376:Rodent Diseases / Q000473:pathology*; D012867:Skin / Q000473:pathology