Bone marrow changes in adjuvant-induced and collagen-induced arthritis. Interleukin-1 and interleukin-6 activity and abnormal myelopoiesis.
OBJECTIVE
To investigate the role of bone marrow in arthritis.


METHODS
Bone marrow changes over time were investigated in rats with adjuvant-induced and collagen-induced arthritis, using bioassay techniques and histologic analysis.


RESULTS
In both animal models, bone marrow interleukin-1 and interleukin-6 activity began to rise before the onset of arthritis and increased in relation to the progression of arthritis. Enhanced myelopoiesis in the bone marrow was noted in conjunction with the increased cytokine activity.


CONCLUSIONS
Bone marrow changes such as those demonstrated in this study may be common to various models of induced arthritis and may have an important role in the pathogenesis of this disease.
Hayashida
K
K
Department of Orthopedic Surgery, Osaka University Medical School, Japan.
Ochi
T
T
Fujimoto
M
M
Owaki
H
H
Shimaoka
Y
Y
Ono
K
K
Matsumoto
K
K
D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D001169:Arthritis, Experimental / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000378:metabolism*; D001853:Bone Marrow / Q000378:metabolism* / Q000473:pathology; D003094:Collagen; D007375:Interleukin-1 / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains
D007375:Interleukin-1; D015850:Interleukin-6; D003094:Collagen