Sialoadenitis in experimental graft-versus-host disease. An animal model of Sjögren's syndrome.
Using light microscopic, immunohistochemical, and ultrastructural techniques, we studied sialoadenitis in mice with chronic graft-versus-host disease (GVHD). To induce chronic GVHD, DBA/2 spleen cells were injected into nonirradiated (C57BL/6 x DBA/2)F1 mice. By light and electron microscopy, the submandibular gland lesion was characterized by mononuclear cell infiltration around the interlobular ducts, often with parenchymal destruction. Immunohistochemically, T cells predominated. The ratio of CD4+ to CD8+ T cells ranged from 1.9:1 to 6:1, with an average of 3.6:1. Lesser numbers of B cells, plasma cells, and macrophages were also present. Histologically, lymphocytic sialoadenitis in chronic GVHD mice was very similar to that reported in patients with chronic GVHD and Sjögren's syndrome.
Fujiwara
K
K
Department of Pathology, Saga Medical School, Japan.
Sakaguchi
N
N
Watanabe
T
T
D000818:Animals; D016516:CD4-CD8 Ratio; D002908:Chronic Disease; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D051379:Mice; D008854:Microscopy, Electron; D012793:Sialadenitis / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D012859:Sjogren's Syndrome / Q000276:immunology / Q000378:metabolism / Q000473:pathology*