title: Restoration of sensitivity to sulfonylurea after strict glycaemic control with insulin in non-obese type 2 diabetic subjects.
abstract: Ten non-obese type 2 diabetic patients with secondary failure to sulfonylureas received an intensive insulin therapy (four doses schedule) for 90 days. The glycaemic control was poor at entry (HbA1c = 11.7 +/- 1.2%) and ameliorated significantly after insulin (HbA1c = 7.1 +/- 0.7%, p less than 0.01). The reintroduction of the sulfonylurea after insulin withdrawal resulted in a persistent satisfactory long-term control (300 days) in all, but two diabetics responded no more after about 3 and 4 months of clinical remission (good control on sulfonylurea). Both basal and stimulated (iv glucagon and mixed meal) beta-cell secretory activity increased significantly at 3 months and declined thereafter without falling below baseline values. Three months of strict metabolic control seem to restore the sensitivity to sulfonylurea by enhancing beta-cell secretory activity in non-obese type 2 diabetic patients.
authors.affiliation: Chair of Geriatric Pathology, First Faculty of Medicine, University of Naples, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Torella
authors.forename: T
authors.initials: T
authors.lastname: Salvatore
authors.forename: D
authors.initials: D
authors.lastname: Cozzolino
authors.forename: R
authors.initials: R
authors.lastname: Giunta
authors.forename: A
authors.initials: A
authors.lastname: Quatraro
authors.forename: D
authors.initials: D
authors.lastname: Giugliano
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D003927:Diet, Diabetic; D004334:Drug Administration Schedule; D004435:Eating; D005260:Female; D005934:Glucagon / Q000097:blood; D005905:Glyburide / Q000008:administration & dosage / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D005934:Glucagon; D005905:Glyburide; D006442:Glycated Hemoglobin; D007328:Insulin