title: Evaluation of hepatic density change by dynamic CT in healthy humans and in patients with chronic liver diseases.
abstract: Dynamic computed tomography using 0.4 ml/kg of 65% meglumine diatrizoate was performed to estimate pharmacokinetics of contrast media in the liver in healthy controls (N = 11), in patients with chronic viral hepatitis (N = 17), posthepatic liver cirrhosis (N = 21), and alcoholic liver cirrhosis (N = 23). The time of peak enhancement (the time interval between peak aortic and liver enhancement) was significantly different between each group. Alcoholic liver cirrhosis was the most prolonged, followed by posthepatic liver cirrhosis, chronic viral hepatitis, and finally controls. A peak enhancement time of 28 sec had a diagnostic accuracy of 97% for chronic liver diseases. A time greater than 44 sec had a diagnostic accuracy for cirrhosis of 96%. The decay time (the time from peak enhancement of the liver to the curve's center of gravity) was also significantly different between each group. Again, alcoholic liver cirrhosis was the longest, followed by posthepatic liver cirrhosis, chronic viral hepatitis, and then the controls. Dynamic computed tomography has many potential applications in studying intrahepatic physiologic events and may contain diagnostic information for chronic liver diseases.
authors.affiliation: Saiseikai-Wakakusa Hospital, Kanagawa and Second Department of Medicine, Toho University School of Medicine, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sugano
authors.forename: T
authors.initials: T
authors.lastname: Okajima
authors.forename: S
authors.initials: S
authors.lastname: Kubo
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sumino
authors.forename: T
authors.initials: T
authors.lastname: Abei
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media / Q000493:pharmacokinetics*; D003974:Diatrizoate Meglumine / Q000378:metabolism; D005260:Female; D006521:Hepatitis, Chronic / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000378:metabolism*; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D003974:Diatrizoate Meglumine