A method for rapid and frequent blood collection from the rat tail vein.
A technique is described for the collection of blood samples after dilation of rat tail veins using a controlled temperature device. Frequent blood samples of seven or eight per rat were collected during a 6-hr period. Further samples were taken from the same vein after recannulation during the next 5 days. This technique was also used to administer drugs intravenously through one vein and to collect blood samples from the contralateral vein.
Frank
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Department of Corporate Drug Development, Searle, Skokie, Illinois 60077.
Schoenhard
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GL
Burton
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E
D000818:Animals; D001800:Blood Specimen Collection / Q000379:methods*; D006358:Hot Temperature; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013623:Tail / Q000098:blood supply*; D014680:Veins