Urine retention due to intra-spinal cord injection of colchicine in rats: improved recovery of bladder function by monosialoganglioside GM1 and nerve growth factor administration.
Intra-spinal cord injection of a low dose of colchicine (2 micrograms/rat) at the lumbar level affects the micturition reflex leading to voiding suppression, bladder hypertrophy and overflow incontinence which lasts about four weeks. The administration of nerve growth factor and monosialoganglioside GM1 normalizes urine output within 3 days and improves recovery of the bladder contraction tested by a cystometric analysis.
Baraldi
M
M
Chair of Pharmacology and Pharmacognosy, School of Pharmacy, University of Modena, Italy.
Zanoli
P
P
Truzzi
C
C
Paro
M
M
Italiano
G
G
Prosdocimi
M
M
D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D005260:Female; D005677:G(M1) Ganglioside / Q000494:pharmacology* / Q000502:physiology*; D007267:Injections; D009414:Nerve Growth Factors / Q000494:pharmacology* / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects* / Q000503:physiopathology*; D001743:Urinary Bladder / Q000294:innervation*; D016055:Urinary Retention / Q000139:chemically induced* / Q000503:physiopathology*; D014554:Urination / Q000187:drug effects / Q000502:physiology; D014563:Urodynamics / Q000187:drug effects* / Q000502:physiology*
D009414:Nerve Growth Factors; D005677:G(M1) Ganglioside; D003078:Colchicine