title: Preliminary study on auxiliary value of serum basic fetoprotein in diagnosing lung cancer.
abstract: To characterize basic fetoprotein (BFP) as a new tumor marker, we measured serum levels of BFP and 5 other tumor markers (CA19-9, CEA, NSE, SCC, and TPA) concomitantly in 65 patients with lung cancer, 57 patients with benign pulmonary disease, and 40 healthy volunteers. The sensitivity of BFP was 43%, the specificity 82% and the accuracy 61%. The positivity increased in relation to stage of the disease. There was no correlation between positivity of BFP and histologic type. On the whole, BFP appeared to be analogous to TPA in terms of broad spectrum and to have an auxiliary value in diagnosing lung cancer.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushima
authors.forename: H
authors.initials: H
authors.lastname: Tsuji
authors.forename: S
authors.initials: S
authors.lastname: Izumi
authors.forename: H
authors.initials: H
authors.lastname: Hirata
authors.forename: Y
authors.initials: Y
authors.lastname: Kin
authors.forename: A
authors.initials: A
authors.lastname: Kawasaki
authors.forename: S
authors.initials: S
authors.lastname: Matsui
authors.forename: A
authors.initials: A
authors.lastname: Yokoyama
authors.forename: T
authors.initials: T
authors.lastname: Morikage
authors.forename: S
authors.initials: S
authors.lastname: Yano
mesh_terms: D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C031192:oncofetal antigens