Effect of neo red cells on the canine hemorrhagic shock model.
This study evaluated the newly developed artificial red blood cells named Neo Red Cells (NRC) after hemorrhagic shock in mongrel dogs. NRC is prepared as microcapsules by a method in which stroma-free hemoglobin is encapsulated using a bimolecular lipid membrane called liposome. The particle size is 0.2 micron, methemoglobin content is less than 5% and the hemoglobin concentration is 5.6 g/dl. We analyzed blood gases and hemodynamics and carried out laboratory examinations after 59-88% blood exchange using NRC. The hemodynamic parameters returned to the normal range after NRC. Inhaling normal room air, oxygen carried by NRC was 60.40% at the exchange rate of 88%. Renal and hepatic function and other laboratory findings were normal after administration of NRC. After further study and improvement NRC could be considered suitable as artificial blood for treatment of hemorrhagic shock.
Usuba
A
A
First Department of Surgery, Fukushima Medical College, Japan.
Motoki
R
R
Miyauchi
Y
Y
Suzuki
K
K
Takahashi
A
A
D000818:Animals; D001802:Blood Substitutes; D004285:Dogs; D004337:Drug Carriers; D006454:Hemoglobins; D008081:Liposomes; D012771:Shock, Hemorrhagic / Q000628:therapy*
D001802:Blood Substitutes; D004337:Drug Carriers; D006454:Hemoglobins; D008081:Liposomes; C016484:hemoglobin, stroma free