Chromosomal localization of the major histocompatibility complex (MHC) in the rhesus monkey and chimpanzee by fluorescence in situ hybridization.
Genes for the major histocompatibility complex (MHC) were localized by fluorescence in situ hybridization to the long arm of rhesus monkey chromosome 5. This localization contradicts previous reports, based on genetic investigation of somatic cell hybrids, that placed the MHC on chromosome 2 of this species. In the chimpanzee, the MHC loci were localized to 5p21.3, corresponding precisely to their location on human chromosome 6p21.3.
Hirai
M
M
Department of Anthropology, Faculty of Science, University of Tokyo, Japan.
Takahashi
E
E
Ishida
T
T
Hori
T
T
D000818:Animals; D002874:Chromosome Mapping; D003181:Complement C4 / Q000235:genetics*; D015342:DNA Probes; D005453:Fluorescence; D015235:HLA-B Antigens / Q000235:genetics*; D008253:Macaca mulatta / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes / Q000235:genetics*; D013255:Steroid 21-Hydroxylase / Q000235:genetics*
D003181:Complement C4; D015342:DNA Probes; D015235:HLA-B Antigens; D013255:Steroid 21-Hydroxylase