title: Localized epidermal necrolysis (erythema multiforme-like reaction) following intravenous injection of vinblastine.
abstract: We report a case of localized epidermal necrolysis that developed 24 hours after an intravenous injection of vinblastine. Clinically, the lesions consisted of erythematous macules, vesicles, and bullae with a linear arrangement over the injected vein. Histologically, the lesions showed features closely resembling erythema multiforme (epidermal necrolysis). We discuss the pathogenesis of this curious cutaneous drug reaction and review the literature concerning local cutaneous complications associated with intravenously administered chemotherapeutic agents.
authors.affiliation: Department of Dermatology, Our Lady of the Conception Clinic, Jimenez Diaz Foundation, Independent University, Madrid, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Arias
authors.forename: L
authors.initials: L
authors.lastname: Requena
authors.forename: A
authors.initials: A
authors.lastname: Hasson
authors.forename: M
authors.initials: M
authors.lastname: Gutierrez
authors.forename: M
authors.initials: M
authors.lastname: Domine
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: A
authors.initials: A
authors.lastname: Barat
mesh_terms: D004892:Erythema Multiforme / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014747:Vinblastine