[A study of aneuploid induction by three mitotic arrestants in mouse bone marrow cells].
Three mitotic arrestants, i.e., colchicine (COL), econazole(EZ) and hydroquinone (HQ) have been assayed by means of C-Mitotic (CM) effects, micronucleus (MN) and chromosomal aberration (CA) test for their effects of aneuploid induction in mouse bone marrow cells COL induced poly/aneuploid in mouse bone marrow cells. EZ was weakly positive in CM effects test but it may not induce aneuploid in mammalian cells. HQ could not only be a clastogen but also an aneuploid inducer. The results indicated that the comparative employment of the three cytogenetic criteria could be quite useful for detecting aneuploidy inducers in mammalian somatic cells in vivo.
Wang
X
X
Biology Department, Yunnan Normal University, Kunming.
Miller
B
B
Kliesch
U
U
Adler
I D
ID
D000782:Aneuploidy; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D003078:Colchicine / Q000494:pharmacology*; D004464:Econazole / Q000494:pharmacology*; D005260:Female; D006873:Hydroquinones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D008938:Mitosis / Q000187:drug effects*
D006873:Hydroquinones; D004464:Econazole; D003078:Colchicine; C031927:hydroquinone