Modelling the influence of risk factors on familial aggregation of disease.
One often observes a familial resemblance of risk factors of disease. The following question then arises: How much familial aggregation of cases of disease would be expected because of this resemblance? This problem is attacked through a particular model where the risk is supposed to depend exponentially on the risk factors. Only pairs of relatives (father/son) are considered. The calculations are performed both with normally distributed risk factors and with particular skewed distributions. An application to coronary heart disease is given.
Aalen
O O
OO
Section of Medical Statistics, University of Oslo, Norway.
D000704:Analysis of Variance; D001794:Blood Pressure; D003327:Coronary Disease / Q000209:etiology / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000453:epidemiology*; D006801:Humans; D006937:Hypercholesterolemia / Q000235:genetics; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D015233:Models, Statistical; D012307:Risk Factors