title: [The effect of the sedative and analgesic detomidine for laryngoscopy of adult horses and foals].
abstract: Detomidine was used in this field trial effectively as a sedative and analgesic for laryngoscopic examinations in a total of 193 foals and 806 mature horses (Hanoverians). Detomidine was given either i.v. in foals 3 to 11 months old (20 micrograms/kg) and in mature horses (15 micrograms/kg), or i.m. in foals below 6 months of age (35 micrograms/kg). After i.v. administration, laryngoscopy was tolerated in more than 90% of all animals without additional use of a twitch, while in foals treated i.m. more than 70% required a twitch in order to enable this procedure. The effectiveness of detomidine was influenced by dose, route of administration, the time interval between treatment and examination and the degree of excitement before treatment, but not by sex. Profound bradycardia was evident in all treated animals, but arrhythmias were seen only in animals older than 4 months and were more pronounced in horses with a lower resting heart rate. These cardiovascular responses never endangered any of the treated animals. A transient dyspnea was seen in 13 foals (6.7%) and 10 horses (1.2%). Other side effects were rare. The foaling rate of 297 mares treated at any time during the first 8 months of pregnancy was 66.7%. A comparison with 5499 untreated, contemporary controls revealed a foaling rate of 61.0%. Hence treatments had no adverse effects on pregnancies.
authors.affiliation: Klinik für Pferde, Tierärztlichen Hochschule Hannover.
authors.forename: V B
authors.initials: VB
authors.lastname: Ohnesorge
authors.forename: E
authors.initials: E
authors.lastname: Deegen
authors.forename: W
authors.initials: W
authors.lastname: Jöchle
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D005260:Female; D006736:Horses / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D007828:Laryngoscopy / Q000662:veterinary; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D007093:Imidazoles; C041255:detomidine
vernacular_title: Zur Wirkung des Sedativums und Analgetikums Detomidin im Rahmen der Laryngoskopie von erwachsenen Pferden und Fohlen.