[Monoamine oxidase inhibitory effects of pentanthrene type heterocyclic compounds].
Pentanthrene type heterocyclic compounds, which contain oxazole, isoxazole, oxadiazole, thiazole, isothiazole, thiadiazole or pyrrole ring as C-ring, and naphthalene, quinoline, isoquinoline or quinoxaline ring as A.B-ring, were prepared, and their monoamine oxidase (MAO) inhibitory activities were examined. As expected from our previous investigation on the structure-activity relationship of this series, most of them showed strong inhibitory potency to both MAO-A and MAO-B. However, a few indicated highly selective inhibition for either of MAO subtypes.
Noda
A
A
Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Noda
H
H
Imamura
T
T
Ono
Y
Y
Morita
M
M
Kai
M
M
Mine
S
S
Goto
S
S
D000818:Animals; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D006571:Heterocyclic Compounds; D008996:Monoamine Oxidase Inhibitors