The osteocalcin gene promoter: stimulated by vitamins A and D, inhibited by cell-growth factors Jun-Fos.
The gene of the bone protein osteocalcin has a promoter region recognized by the receptors for 1,25-dihydroxyvitamin D3 and retinoic acid, both of which stimulate transcription. Unexpectedly, this same gene element interacts with the cell-proliferation factors Jun-Fos, which inhibit osteocalcin gene transcription.
D000818:Animals; D006801:Humans; D015675:Osteocalcin / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000187:drug effects*; D011518:Proto-Oncogene Proteins / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000494:pharmacology; D016755:Proto-Oncogene Proteins c-jun / Q000494:pharmacology; D014801:Vitamin A / Q000494:pharmacology*; D014807:Vitamin D / Q000494:pharmacology*
D011518:Proto-Oncogene Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D015675:Osteocalcin; D014801:Vitamin A; D014807:Vitamin D