Sexual receptivity of adult female rats prenatally intoxicated with alcohol on gestational day 8.
On gestational day 8 (GD 8), pregnant albino rats received two IP injections, spaced by 4 hours, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline. Adult females exposed to ethanol in utero showed greater sensitivity to estrogen, but not to estrogen plus progesterone, for induction of lordotic response. The 5-HT1 receptor agonist 5-methoxy-N,N-dimethyl-tryptamine (5-MeODMT) had a significantly smaller effect in inhibiting lordosis response in experimental rats. The greater sensitivity to estrogen and lower sensitivity to the receptor agonist could be a consequence of long-term changes in central neurotransmitter systems induced by acute intoxication with ethanol on GD 8.
Minetti
S A
SA
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Fulginiti
S
S
D000435:Alcoholic Intoxication / Q000196:embryology / Q000503:physiopathology*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005865:Gestational Age; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D010052:Ovariectomy; D011187:Posture; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012016:Reference Values; D012726:Sexual Behavior, Animal / Q000187:drug effects
D008732:Methoxydimethyltryptamines; D011374:Progesterone; D004958:Estradiol