Effect of glycine on retroperitoneal and intraperitoneal organs in the rat model.
Twenty Sprague Dawley rats were administered various doses of 1.5% amino acetic acid (glycine), lactated Ringer's, and water, both intravenously and retroperitoneally, in an attempt to recreate the post-transurethral resection syndrome in a rat model. The kidneys, liver, and pancreas were harvested 6 hours after exposure and examined pathologically. Water and lactated Ringer's had no histologic effect on these organs. Glycine was found to have a toxic effect on the kidneys and liver and this effect was dose related. Based on these results, it is postulated that glycine toxicity may play a significant role as a causative factor in producing the post-transurethral resection syndrome.
Maatman
T J
TJ
Department of Urology, Metropolitan Hospital, Grand Rapids, Michigan.
Musselman
P
P
Kwak
Y S
YS
Resnick
M I
MI
D000818:Animals; D004195:Disease Models, Animal; D005998:Glycine / Q000494:pharmacology*; D007552:Isotonic Solutions / Q000494:pharmacology; D007668:Kidney / Q000166:cytology / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D010179:Pancreas / Q000166:cytology / Q000187:drug effects*; D010529:Peritoneal Cavity; D010533:Peritoneal Lavage / Q000009:adverse effects; D011183:Postoperative Complications / Q000209:etiology*; D011468:Prostatectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012187:Retroperitoneal Space; D000077331:Ringer's Solution; D014867:Water / Q000494:pharmacology
D007552:Isotonic Solutions; D014867:Water; D000077331:Ringer's Solution; D005998:Glycine