Self-regulated delivery of insulin from microcapsules.
We previously developed self-regulating insulin delivery systems using concanavalin A (Con A)-bound succinyl-amidophenyl-glucopyranoside insulin (SAPG-insulin) in pouch membrane which exhibited long lag times for exchange diffusion in response to glucose changes. We report here the preparation of a new system with a short exchange diffusion onset composed of hydrophilic nylon microcapsules containing Con A and SAPG-insulin in vitro. It is considered that this SAPG-insulin system can quickly respond to glucose changes when it is composed of at least two layers which include active Con A and where unbound SAPG-insulin permeation is the rate limiting step.
Makino
K
K
Center for Controlled Chemical Delivery, University of Utah, Salt Lake City 84108.
Mack
E J
EJ
Okano
T
T
Kim
S W
SW
D001786:Blood Glucose / Q000378:metabolism*; D002214:Capsules; D003208:Concanavalin A; D004058:Diffusion; D016503:Drug Delivery Systems; D005246:Feedback / Q000502:physiology; D005960:Glucosides / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008567:Membranes, Artificial
D001786:Blood Glucose; D002214:Capsules; D005960:Glucosides; D007328:Insulin; D008567:Membranes, Artificial; C066740:insulin, 4-succinylamidophenylglucopyranoside-; D003208:Concanavalin A