[The relationship between the effect of atenolol on the baroreceptor reflex and its hypotensive action in hypertension patients].
A study was made of the influence of atenolol on the sinocarotid and cardiopulmonary baroreceptor reflexes (BR) in patients with essential hypertension. Sinocarotid mechanoreceptors were activated by means of a cervical decompression pressure chamber. The cardiopulmonary BR was tested by changing venous return with the aid of local decompression of the lower limbs. The changes in the hemodynamic parameters were estimated by continuous recording of the mean arterial pressure (AP), tetrapolar rheography, direct manometry arterial pressure (AP), tetrapolar rheography, direct manometry (right atrium), and venous occlusion plethysmography. The drug hypotensive effect was shown to be related to modulation of the sinocarotid BR. It has been demonstrated that there is no relationship between atenolol suppression of the vasoconstrictor cardiopulmonary BR and the drug ability for AP reduction.
Zverev
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Tsyrlin
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VA
D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001262:Atenolol / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002346:Carotid Sinus / Q000187:drug effects; D004341:Drug Evaluation; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects*
D000959:Antihypertensive Agents; D001262:Atenolol
Zavisimost' mezhdu vliianiem atenolola na baroretseptornyĭ refleks i ego gipotenzivnym deĭstviem u bol'nykh gipertonicheskoĭ bolezn'iu.