[Genetic activity of aminofluorene and 2-acetylaminofluorene in strains of Saccharomycetes under conditions of in vitro metabolic activation: influence of rad 1-5 mutation].
It has been shown that the rad1-5 mutation which alters excision repair in Saccharomyces cerevisiae yeast increased reversion frequency of the ochre mutation his7-1 and the frequency of intragenic mitotic recombination in the LYS2 gene induced by 2-aminofluorene and 2-acetylaminofluorene, as compared with the wild type strains activated in vitro by 39 mix from chicken liver.
Pshenichnov
M R
MR
Pavlov
Iu I
IuI
D015073:2-Acetylaminofluorene / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation / Q000502:physiology; D002645:Chickens; D005449:Fluorenes / Q000633:toxicity*; D015966:Gene Expression Regulation, Fungal / Q000187:drug effects*; D009153:Mutagens / Q000493:pharmacokinetics / Q000633:toxicity*; D009154:Mutation; D011995:Recombination, Genetic / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D005449:Fluorenes; D009153:Mutagens; C012177:2-aminofluorene; D015073:2-Acetylaminofluorene
Geneticheskaia aktivnost' 2-aminofliuorena i 2-atsetilaminofliuorena u shtammov drozhzheĭ sakharomitsetov v usloviiakh metabolicheskoĭ aktivatsii i vitro: vliianie mutatsii rad 1-5.