C1: molecular interactions with activating systems.
The molecular events controlling complement activation have been gradually unravelled over the past three decades, stimulated by improved isolation procedures and a better understanding of the roles of individual proteins. In this review, Bob Sim and Ken Reid examine the interactions between C1q and its numerous ligands in the initiation of the classical pathway cascade.
Sim
R B
RB
Dept of Biochemistry, University of Oxford, UK.
Reid
K B
KB
D000818:Animals; D003167:Complement Activation / Q000276:immunology*; D003172:Complement C1 / Q000276:immunology*; D015922:Complement C1q / Q000276:immunology; D003171:Complement Pathway, Classical / Q000276:immunology; D006801:Humans
D003172:Complement C1; D015922:Complement C1q