[Morphological changes in the mucosa of the stomach and the small intestine of rats under the action of mebendazole].
The effect of mebendazole on the gastric and intestinal mucosa was studied in 52 intact white rats. It was shown that the drug caused a significant damage to the mucosa, especially of goblet cells of villi and crypts and interfere with the mucoid secretion. The alterations after mebendazole administration were more severe than those caused by naphthamon. On the 13-15th day after the treatment the complete restoration of the damage was not seen.
Blagov
N A
NA
Miagkova
M A
MA
Firsov
V N
VN
Zhuravleva
T B
TB
Petrova
I V
IV
D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D001598:Bephenium Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects* / Q000473:pathology; D008463:Mebendazole / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000871:Anthelmintics; D001598:Bephenium Compounds; C006739:bephenium hydroxynaphthoate; D008463:Mebendazole
Morfologicheskie izmeneniia slizistoĭ obolochki zheludka i tonkoĭ kishki krys pod deĭstviem mebendazola.