title: Gamete intrafallopian transfer (GIFT) compared with intrauterine insemination in the treatment of unexplained infertility.
abstract: OBJECTIVE
  To compare GIFT, intrauterine insemination (IUI) with, and without, ovarian hyperstimulation in the treatment of unexplained infertility.
  
  
  METHODS
  Women randomly allocated to one of three treatment protocols.
  
  
  METHODS
  Northern Regional Fertility Centre.
  
  
  METHODS
  59 couples with unexplained infertility of more than 3 years duration.
  
  
  METHODS
  Three cycles of either GIFT, IUI after ovarian hyperstimulation or IUI in a spontaneous cycle.
  
  
  METHODS
  Pregnancy resulting in a live birth.
  
  
  RESULTS
  Fecundabilities were 0.12 after GIFT, 0.018 after ovarian hyperstimulation and IUI, and 0.018 after IUI in a spontaneous cycle. The fecundability after IUI was no different from that which would be expected without treatment in these couples but fecundability was significantly better (P greater than 0.02) after GIFT.
  
  
  CONCLUSIONS
  This trial does not support the use of IUI in the treatment of unexplained infertility but confirms the value of GIFT.
authors.affiliation: Department of Obstetrics and Gynaecology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
authors.forename: A P
authors.initials: AP
authors.lastname: Murdoch
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: M
authors.initials: M
authors.lastname: Mahroo
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: W
authors.initials: W
authors.lastname: Dunlop
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D005260:Female; D005298:Fertility; D015181:Gamete Intrafallopian Transfer; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008596:Menotropins / Q000008:administration & dosage; D006080:Ovarian Follicle / Q000187:drug effects; D010062:Ovulation Induction; D011247:Pregnancy
chemical_list: D006063:Chorionic Gonadotropin; D008596:Menotropins