[Qualitative and quantitative assessment of blood erythrocytes of intact animals under the effect of 5-fluorouracil in solution and in microspheres made of acetylcellulose combined with short-term gas hypoxia].
Resistance of erythrocyte membranes, estimated by means of ultrasound hemolysis, was altered 7 days before the cells quantitative changes after simultaneous treatment of intact animals with 5-fluorouracil, administered as solution or in acetate cellulose drug-containing granules, and short-term gas hypoxia. Simultaneous effect of 5-fluorouracil and hypoxia was less toxic for erythropoiesis, while the long-term form of the drug did not affect considerably the liver tissue functions.
Bazhinova
N V
NV
Zaretskaia
I S
IS
Valiaeva
T Iu
TIu
Rusakov
I G
IG
D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives; D004337:Drug Carriers; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D005472:Fluorouracil / Q000494:pharmacology*; D000860:Hypoxia / Q000097:blood*; D008297:Male; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D000637:Transaminases / Q000378:metabolism
D004337:Drug Carriers; D012996:Solutions; C005062:acetylcellulose; D002482:Cellulose; D000637:Transaminases; D005472:Fluorouracil
Kachestvennaia i kolichestvennaia otsenka éritrotsitov krovi intaktnykh zhivotnykh pri deĭstvii 5-ftoruratsila v rastvore i v mikrosferakh iz atsetiltselliulozy v sochetanii s kratkovremennoĭ gazovoĭ gipoksieĭ.