Renal function after cardiopulmonary bypass in children: comparison of dopamine with dobutamine.
We have compared low dose dopamine with dobutamine in conserving renal function in 142 children younger than 10 yr undergoing cardiopulmonary bypass (CPB). Patients were allocated randomly to receive a continuous infusion of either dopamine 2.5 micrograms kg-1 min-1 (group 1) or dobutamine 2.5 micrograms kg-1 min-1 (group 2) from the time of induction of anaesthesia. Administration of inotropes and diuretics was controlled strictly to agreed regimens. There was no clinical or statistically significant difference between the two groups in postoperative urine output, serum concentration of creatinine, fractional sodium excretion or need for diuretic therapy. This was true also of the subgroup of patients who received no other inotropic support. However, the subgroup of patients in group 1 who underwent periods of CPB in excess of 2 h (n = 17) had persistently greater postoperative serum concentrations of creatinine. Low dose dopamine did not appear to be superior to dobutamine for protection of renal function in these patients.
Wenstone
R
R
Department of Paediatric Anaesthesia, Royal Liverpool Children's Hospital.
Campbell
J M
JM
Booker
P D
PD
McKay
R
R
D058186:Acute Kidney Injury / Q000517:prevention & control; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000627:therapeutic use; D004280:Dobutamine / Q000008:administration & dosage*; D004298:Dopamine / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007432:Intraoperative Period; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D014556:Urine
D004232:Diuretics; D004280:Dobutamine; D003404:Creatinine; D004298:Dopamine