Effect of high-frequency hearing loss on compound action potentials recorded from the intracranial portion of the human eighth nerve.
Compound action potentials (CAP) were recorded from the exposed intracranial portion of the eighth nerve to stimulation with click sounds in patients with sensorineural high-frequency hearing loss who underwent microvascular decompression (MVD) operations to treat trigeminal neuralgia (TN). In patients with normal hearing the CAP recorded in that way is characterized by a negative peak, preceded by a small positivity and followed by a positivity and sometimes a second negative peak. In patients with high-frequency hearing loss the CAP also usually had an initial sharp negative peak in response to clicks of high intensity (105 to 110 dB Pe SPL), similar to findings in patients with normal hearing, but in patients with high-frequency hearing loss the initial negative peak was often followed by a slow negative deflection. The latency of the initial negative peak in the CAP in patients with high-frequency hearing loss was longer than the latency of this peak in patients with normal hearing, but the difference in latencies of this peak to condensation and rarefaction clicks was small. When the stimulus intensity was lowered the amplitude of the initial peak decreased, and the CAP became dominated by a broad negative peak with a latency of 6 to 8 ms. In 11 of 15 patients with severe high-frequency hearing loss, a series of quasi-periodic waves was superimposed on the CAP. The frequency of these waves varied between 500 and 1200 Hz, and the waves could be detected between 6 and 16 ms after presentation of the click stimulus. These waves were usually present in the response to stimuli in the intensity range from 75 to 110 dB Pe SPL. Only 4 of 17 patients with normal hearing had similar waves.
Møller
A R
AR
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania.
Jho
H D
HD
D000161:Acoustic Stimulation; D000200:Action Potentials; D016057:Evoked Potentials, Auditory, Brain Stem; D006316:Hearing Loss, High-Frequency / Q000150:complications / Q000503:physiopathology*; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000503:physiopathology; D006801:Humans; D014277:Trigeminal Neuralgia / Q000150:complications / Q000601:surgery; D000159:Vestibulocochlear Nerve / Q000503:physiopathology