[Individual choice of ribonuclease and fluorofur doses in the treatment of patients with acute pancreatitis].
A method is suggested for individual calculation of optimal doses of ribonuclease and fluorofur on the basis of a standardized index--the degree of severity. A CM 1404 computer was used in solving the problem. From analysis of 500 case records by means of programs of discriminant and multidimensional linear regressive analysis a mathematical dependence was found between some parameters indirectly reflecting the severity of the patient's condition, the ribonuclease dose, and the efficacy of the treatment. A similar dependence for fluorofur was also studied. The discovered statistical regularity was realized as a nomogram for calculating the degree of severity and individual optimal doses of ribonuclease and fluorofur. The method was used in 114 patients. All the compared indices were found to be better than those in the group of patients for whom the dose of the agents (ribonuclease) was calculated on the basis of a constant dose per kg weight.
Ivanov
P A
PA
Shcherbiuk
A N
AN
Grishin
A V
AV
Kurdiaev
I G
IG
Miroshenkova
E Iu
EIu
Syromiatnikova
E D
ED
D000208:Acute Disease; D000368:Aged; D004360:Drug Therapy, Computer-Assisted; D005260:Female; D006801:Humans; D010195:Pancreatitis / Q000188:drug therapy*; D012260:Ribonucleases / Q000008:administration & dosage*; D005641:Tegafur / Q000008:administration & dosage*
D005641:Tegafur; D012260:Ribonucleases
Individual'nyĭ vybor doz ribonukleazy i ftorafura pri lechenii bol'nykh ostrym pankreatitom.