Tiapride as treatment for certain patients with idiopathic torsion dystonia.
Five female patients with idiopathic torsion dystonia (ITD) responded to treatment with tiapride, a selective D-2 dopamine antagonist. Previous treatments with various drugs, including anticholinergics, were ineffective. It is suggested that the previously reported genetic subgroups of ITD respond to different drug regimens. The autosomal dominant group responded to anticholinergics, while the autosomal recessive group responded best to a selective D-2 dopamine antagonist.
Arlazoroff
A
A
Department of Neurology, Assaf Harofeh Medical Center, Tel Aviv, Israel.
Klein
C
C
Meiner
Z
Z
Milo
R
R
Theitler
J
J
Carpel
C L
CL
D000328:Adult; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004422:Dystonia Musculorum Deformans / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005808:Genes, Recessive / Q000235:genetics; D006236:Handwriting; D006801:Humans; D008875:Middle Aged; D009460:Neurologic Examination; D011597:Psychomotor Performance / Q000187:drug effects; D013976:Tiapamil Hydrochloride / Q000627:therapeutic use*
D013976:Tiapamil Hydrochloride