Linkage analysis of affective disorder using DNA markers on chromosomes 11 and X.
We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c-Ha-ras-1 oncogene and the insulin gene on chromosome 11, or hypoxanthine phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the markers on chromosomes 11 and X was ruled out with the assumption of no recombination.
Nanko
S
S
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Kobayashi
M
M
Gamou
S
S
Kudoh
J
J
Shimizu
N
N
Takazawa
N
N
Kazamatsuri
H
H
Furusho
T
T
D001714:Bipolar Disorder / Q000235:genetics* / Q000523:psychology; D002880:Chromosomes, Human, Pair 11; D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics; D011618:Psychotic Disorders / Q000235:genetics* / Q000523:psychology; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014960:X Chromosome
D005819:Genetic Markers