Calcitonin gene-related peptide-like immunoreactivity and its relation with neurotensin- and corticotropin-releasing hormone-like immunoreactive neurons in the bed nuclei of the stria terminalis in the rat.
The distribution of calcitonin gene-related peptide (CGRP)-like immunoreactive (LI) nerve cells and terminals (BST) was studied in the rat. Only the fusiform nucleus was found to consistently contain CGRP-LI neurons. The CRGP-LI terminals had a wide distribution in the BST, being most numerous in the oval and the fusiform nuclei. In the oval nucleus the CGRP-LI terminals formed characteristic "baskets." Since the oval nucleus was known to be studded with neurotensin (NT)- and corticotropin-releasing hormone (CRH)-LI neurons, the relationship of the CGRP-LI nerves to NT- and CRH-LI neurons was investigated by means of a double immunostaining technique. A part of the CGRP-LI baskets were found to contain NT- or CGRP-LI neurons. The possible involvement of the CGRP/NT or CRH relationship in reciprocal connection between the BST and the parabrachial nucleus and in cardiovascular regulation is discussed.
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Department of Neurobiology, Fourth Military Medical University, Xian, People's Republic of China.
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D003346:Corticotropin-Releasing Hormone / Q000032:analysis*; D007106:Immune Sera; D007150:Immunohistochemistry; D008032:Limbic System / Q000166:cytology; D008297:Male; D009412:Nerve Fibers / Q000648:ultrastructure*; D009474:Neurons / Q000166:cytology*; D009496:Neurotensin / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000033:anatomy & histology / Q000166:cytology*
D007106:Immune Sera; D009496:Neurotensin; D003346:Corticotropin-Releasing Hormone; D015740:Calcitonin Gene-Related Peptide