title: Coagulation changes after an experimental missile wound to the brain in the cat.
abstract: Platelet studies (total number and platelet aggregation) and coagulation assays (fibrinogen, factor VIII, and anti-thrombin III) were performed on systemic arterial blood of four control and four experimental adult cats that sustained a penetrating missile injury to the brain. Among the brain-wounded, a significant decrease in the total number of platelets and aggregates occurred 120 minutes after injury. Fibrinogen levels decreased significantly in the brain-wounded animals by 240 minutes after injury and continued declining until the end of the 6-hour experiment. No significant changes occurred in factor VIII and antithrombin III levels in wounded as compared with control animals. These results indicate that blood coagulation factors are altered following a missile wound to the brain. These alterations may, occasionally, lead to clinically manifested bleeding disorders, specifically disseminated intravascular coagulation. Thus, early analysis and control of the coagulation system in the brain-wounded patient should be considered to prevent and treat bleeding disorders in the setting of penetrating head injury.
authors.affiliation: Department of Neurosurgery, Louisiana State University Medical Center, New Orleans 70112.
authors.forename: D
authors.initials: D
authors.lastname: Awasthi
authors.forename: W A
authors.initials: WA
authors.lastname: Rock
authors.forename: M E
authors.initials: ME
authors.lastname: Carey
authors.forename: J B
authors.initials: JB
authors.lastname: Farrell
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001777:Blood Coagulation; D001930:Brain Injuries / Q000097:blood*; D002415:Cats; D010974:Platelet Aggregation; D010976:Platelet Count; D013997:Time Factors; D014948:Wounds, Gunshot / Q000097:blood*