Tissue-type plasminogen activator of colonic mucosa in ulcerative colitis. Evidence of endothelium-derived fibrinolytic activation.
Microvascular endothelial alterations are thought to be a crucial step for development of hemorrhagic changes in various pathological states. In this study, we determined the activity and amount of tissue-type plasminogen activator (t-PA) in the biopsy specimens from sigmoid colon of patients with ulcerative colitis to evaluate endothelial alterations and vascular changes of permeability. The results of this investigation revealed that mucosal amount of t-PA in the active stage of ulcerative colitis was two- to threefold higher than in healthy controls, while t-PA levels in plasma samples showed no remarkable differences among the groups. Increased t-PA activity appeared to correlate well to the degree of inflammation of colonic mucosa, and t-PA amount was still increased in the inactive stage. The present study indicates that t-PA determination in colonic biopsy specimens may be useful for the evaluation of clinical activity of ulcerative colitis in terms of the mucosal microvascular endothelial changes.
Kurose
I
I
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Miura
S
S
Suematsu
M
M
Serizawa
H
H
Fukumura
D
D
Asako
H
H
Hibi
T
T
Tsuchiya
M
M
D000328:Adult; D000368:Aged; D001706:Biopsy; D003093:Colitis, Ulcerative / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D012809:Colon, Sigmoid / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000473:pathology; D008875:Middle Aged; D010959:Tissue Plasminogen Activator / Q000032:analysis* / Q000097:blood
D010959:Tissue Plasminogen Activator