title: [Study on the extent of peritumoral edema in glioma: its correlation with the proliferative potential and tumor-infiltrating mononuclear cells].
abstract: The correlation between the extent of peritumoral edema and the proliferative potential or the infiltration of mononuclear cells was studied in 17 gliomas. The peritumoral edema was evaluated on contrast enhanced CT scan as the ratio of the low density area around the tumor to the enhanced high density area. The proliferative potential and the infiltration of mononuclear cells into the tumor were investigated immunohistochemically using monoclonal antibody (MAb) against DNA polymerase alpha and anti-Leu MAb's respectively. There was a significant correlation between the extent of the peritumoral edema and the percentage of DNA polymerase alpha positive cells. The degree of the infiltration of mononuclear cells into the tumor tissue also correlated with the extent of peritumoral edema. In gliomas with high proliferative potential and/or severe infiltration of mononuclear cells, the peritumoral edema may be aggravated by disruption of the blood-brain-barrier and increased vascular permeability.
authors.affiliation: Department of Neurological Surgery, Okayama Medical School.
authors.forename: K
authors.initials: K
authors.lastname: Kunishio
authors.forename: T
authors.initials: T
authors.lastname: Maeshiro
authors.forename: T
authors.initials: T
authors.lastname: Matsuhisa
authors.forename: N
authors.initials: N
authors.lastname: Mishima
authors.forename: K
authors.initials: K
authors.lastname: Tsuno
authors.forename: H
authors.initials: H
authors.lastname: Shigematsu
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Furuta
authors.forename: A
authors.initials: A
authors.lastname: Nishimoto
mesh_terms: D001929:Brain Edema / Q000000981:diagnostic imaging / Q000209:etiology*; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D005910:Glioma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology*; D014057:Tomography, X-Ray Computed