Is there a genetic basis for Fuchs' heterochromic uveitis? Discordance in monozygotic twins.
One pair, and probably two pairs, of monozygotic twins are reported with discordance for Fuchs' heterochromic uveitis (FHU). Regular Mendelian inheritance of this disease is now proved to be impossible. The heritability of FHU is low and may be zero. The possibility of any genetic predisposition to the disease and its association with 'simple' heterochromia are discussed.
Jones
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NP
Department of Ophthalmology, University of Manchester.
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AP
D000368:Aged; D004247:DNA / Q000032:analysis; D004200:Diseases in Twins; D005260:Female; D006801:Humans; D015863:Iridocyclitis / Q000235:genetics* / Q000473:pathology; D007498:Iris / Q000473:pathology; D008875:Middle Aged
D004247:DNA