title: Neonatal lupus erythematosus syndrome.
abstract: Three cases of neonatal lupus erythematosus (NLE) syndrome are described. The key diagnostic sign is the erythematous and annular clinical appearance of lesions. The histopathologic findings may be subtle in NLE syndrome compared with discoid or subacute cutaneous lupus erythematosus. Direct immunofluorescence testing may be useful in supplementing the histopathologic evaluation. Detection of immunoglobulins, complement, or both at the basement membrane zone in lesional skin by immunofluorescence occurs in approximately half of cases; a negative study does not preclude the diagnosis of NLE syndrome. Clinical and serologic evaluation of both the infant and the mother are important in establishing a diagnosis of NLE syndrome, particularly when histopathologic findings are subtle.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905.
authors.forename: B
authors.initials: B
authors.lastname: Maynard
authors.forename: K M
authors.initials: KM
authors.lastname: Leiferman
authors.forename: M S
authors.initials: MS
authors.lastname: Peters
mesh_terms: D005455:Fluorescent Antibody Technique; D006801:Humans; D007231:Infant, Newborn; D008178:Lupus Erythematosus, Cutaneous / Q000473:pathology*; D008297:Male; D012867:Skin / Q000473:pathology; D013577:Syndrome