title: Reversible decrease of fluoride resistant acid phosphatase-positive neurons after herpes simplex virus infection.
abstract: Herpes simplex virus (HSV) frequently infects human sensory ganglion neurons, and similar infections have been reported in experimental animals. Reported here is an investigation of in vivo neuronal function after HSV infection. It was observed that the proportion of fluoride resistant acid phosphatase (FRAP)-positive trigeminal ganglion neurons was decreased for several months after experimental infection of mice, and it is suggested that other neuronal functions may also be altered by HSV.
authors.affiliation: Department of Medicine, Penn State University College of Medicine, Hershey 17033.
authors.forename: R B
authors.initials: RB
authors.lastname: Tenser
authors.forename: A L
authors.initials: AL
authors.lastname: Viselli
authors.forename: D H
authors.initials: DH
authors.lastname: Savage
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D005459:Fluorides / Q000494:pharmacology*; D006561:Herpes Simplex / Q000201:enzymology / Q000473:pathology*; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D012584:Sciatic Nerve / Q000502:physiology; D012668:Trigeminal Ganglion / Q000166:cytology / Q000201:enzymology
chemical_list: D000135:Acid Phosphatase; D005459:Fluorides