Plasma platelet-derived growth factor levels in coronary circulation in unstable angina pectoris.
To examine whether plasma platelet-derived growth factor (PDGF) levels are elevated in the coronary circulation of patients with unstable angina, the plasma PDGF levels in the coronary sinus and aortic root were simultaneously examined in 14 patients with unstable angina, 15 with stable exertional angina, and 15 control subjects. The mean plasma PDGF level (pg/ml) in the coronary sinus was significantly higher (p less than 0.01) in patients with unstable angina than in those with stable exertional angina and in control subjects (502.1 +/- 98.7 vs 301.3 +/- 62.5, and 312.7 +/- 62.6). However, there were no significant differences in mean plasma PDGF levels in the aortic root among the 3 groups. It is concluded that PDGF release is increased in the coronary circulation in patients with unstable angina.
Ogawa
H
H
Division of Cardiology, Kumamoto University Medical School, Japan.
Yasue
H
H
Misumi
I
I
Masuda
T
T
Okumura
K
K
Bannai
S
S
Takanashi
N
N
Tsukada
Y
Y
D000368:Aged; D000704:Analysis of Variance; D000787:Angina Pectoris / Q000097:blood / Q000209:etiology; D000789:Angina, Unstable / Q000097:blood*; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000502:physiology; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D011863:Radioimmunoassay
D010982:Platelet-Derived Growth Factor