Subchronic toxicity studies of tri-n-butyltin and triphenyltin acetates in rats.
The effects of a moderate but prolonged exposure of rats to tri-n-butyltin acetate (TBTA) and triphenyltin acetate (TPTA), as might be encountered as residues in yam peel diets, were investigated in rats. These subchronic toxicity studies (16, 8, or 4 mg TBTA/kg and 20, 10 or 5 mg TPTA/kg) showed histopathologic lesions in lungs, liver, intestine and kidney. The hematologic parameters in the groups treated with either compound fell within the normal range for the rats. However, there was a reduction in mean lymphocyte count for rats receiving 10 or 20 mg TPTA/kg, and a reduction in monocyte count in the 20 mg TPTA/kg group. These data indicate a need for further toxicologic studies and cautionary measures to avoid ingestion, inhalation or contamination of dietary materials by these fungicides.
Attahiru
U S
US
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Iyaniwura
T T
TT
Adaudi
A O
AO
Bonire
J J
JJ
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005659:Fungicides, Industrial / Q000633:toxicity*; D006470:Hemorrhage / Q000139:chemically induced; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D009947:Organotin Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014220:Trialkyltin Compounds / Q000633:toxicity*
D005659:Fungicides, Industrial; D009947:Organotin Compounds; D014220:Trialkyltin Compounds; C011559:tributyltin; C011978:phentin acetate