Melatonin modifies the spontaneous multiunit activity recorded in several brain nuclei of freely behaving rats.
Melatonin, a pineal hormone, released photoperiodically, was administered systemically in rats, previously implanted with semimicroelectrodes into six different brain structures. The multiunit electrical activity of these structures was recorded for 10 min before and 60 min after melatonin administration in unanesthetized, freely moving rats. Different melatonin doses (100, 200, 500, and 1000 micrograms/kg) produced changes in the electrical activity of all tested structures. However, amygdala, rostral hypothalamus and mesencephalic reticular formation showed the most important changes. The main effect induced by melatonin was a dose-related decrease of the spontaneous electrical activity. The significance of these effects is discussed within the context of the behavioral and endocrinological effects of melatonin.
Naranjo-Rodríguez
E B
EB
Laboratorio de Farmacología, Facultad de Química, Universidad Nacional Autónoma de México, D.F.
Prieto-Gómez
B
B
Reyes-Vázquez
C
C
D000679:Amygdala / Q000502:physiology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D002421:Caudate Nucleus / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D008839:Microelectrodes; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology; D013788:Thalamus / Q000502:physiology
D008550:Melatonin