title: Ofloxacin intravenous. Compatibility with other antibacterial agents.
abstract: The physical and chemical compatibility of ofloxacin (infusion solution 100 ml = 200 mg) with amoxicillin, amoxicillin + clavulanic acid, flucloxacillin, tobramycin, gentamicin, clindamycin, vancomycin, ceftazidime and piperacillin was investigated. Upon admixture with flucloxacillin a precipitate formed between 7 and 24 hours. No other physical or chemical incompatibilities were observed with any of the other combinations. Ofloxacin may be safely combined with the tested antimicrobial drugs, except for flucloxacillin.
authors.affiliation: Department of Clinical Pharmacy, Maasland Hospital, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Janknegt
authors.forename: T
authors.initials: T
authors.lastname: Stratermans
authors.forename: J
authors.initials: J
authors.lastname: Cilissen
authors.forename: J J
authors.initials: JJ
authors.lastname: Lohman
authors.forename: P M
authors.initials: PM
authors.lastname: Hooymans
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D011232:Chemical Precipitation; D006801:Humans; D007275:Injections, Intravenous; D015242:Ofloxacin / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D015242:Ofloxacin