Interleukin-2 enhances production in 24 hours of infectious human immunodeficiency virus type 1 in vitro by naturally infected mononuclear cells from seropositive donors.
When peripheral blood mononuclear cells from HIV-1 seropositive patients were treated with rIL-2 in vitro a rapid increase of 2-12 fold in production of extracellular infectious HIV-1 occurred, in 6 of 9 experiments. Overall, the increase in the 9 experiments was significant (p less than 0.01) and provides more direct evidence for an enhancing role of IL-2 in naturally infected cells.
Todd
B
B
Sir Albert Sakzewski Virus Research Laboratory, Royal Children's Hospital, Brisbane, Queensland, Australia.
Pope
J H
JH
Georghiou
P
P
D002478:Cells, Cultured; D006679:HIV Seropositivity / Q000382:microbiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007376:Interleukin-2 / Q000502:physiology*; D007963:Leukocytes, Mononuclear / Q000382:microbiology; D013997:Time Factors; D014779:Virus Replication
D007376:Interleukin-2