title: [The long-term toxicity of polychemotherapy in successfully treated testicular carcinoma].
abstract: Of 55 patients with testicular cancer, treated by combination chemotherapy including cisplatin, 21 (mean age 35 [21-51] years) were reexamined for late sequelae of the chemotherapy 1-9 years later. No patient had a recurrence or second malignancy. They all had normal renal function (renal sequence scintigraphy; creatinine clearance). Seven of 20 patients had a polyneuropathy, nine of 18 had high-tone hearing loss. Two patients became fathers after treatment. In nine of 20 patients the serum concentration of follicle-stimulating hormone was raised to above 20 mU/ml, evidence of germ-cell damage. Six of 13 patients had an abnormal ejaculation following retroperitoneal lymphadenectomy or excision of a residual tumour. There was no evidence of any life-limiting toxicity of the chemotherapy.
authors.affiliation: Abteilung für Innere Medizin, Freie Universität, Berlin.
authors.forename: H R
authors.initials: HR
authors.lastname: Schwabe
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
authors.forename: M
authors.initials: M
authors.lastname: Mathew
authors.forename: K J
authors.initials: KJ
authors.lastname: Gräf
authors.forename: T
authors.initials: T
authors.lastname: Sander
authors.forename: M
authors.initials: M
authors.lastname: Cordes
authors.forename: R
authors.initials: R
authors.lastname: Nagel
authors.forename: L
authors.initials: L
authors.lastname: Weissbach
authors.forename: D
authors.initials: D
authors.lastname: Huhn
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D002319:Cardiovascular System / Q000187:drug effects; D002945:Cisplatin / Q000009:adverse effects; D005298:Fertility / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009420:Nervous System / Q000187:drug effects; D012074:Remission Induction; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors
chemical_list: D002945:Cisplatin
vernacular_title: Langfristige Toxizität der Polychemotherapie bei kurativ behandeltem Hodenkarzinom.