Development of thermosensitive peptidyl cell substrate synthesis and artificial fibrin glue.
A totally synthetic fibrin glue was developed. The molecular structure is a co-polymer of N-isopropyl acrylamide (NIAM) and vinyl monomer units with a cell-adhesion peptidyl moiety (Arg-Gyl-Asp). The buffer solution is a viscous liquid at room temperature, but spontaneous precipitation occurs due to thermoresponsive phase transition derived from poly-NIAM. The peptidyl moieties bind to platelet receptors. When applied to tissues, spontaneous precipitation and subsequent platelet aggregation occurred, indicating that the synthetic bioactive polymer effectively functions like fibrin glue.
Matsuda
T
T
Department of Bioengineering, National Cardiovascular Center, Osaka, Japan.
Moghaddam
M J
MJ
D000818:Animals; D001777:Blood Coagulation; D002448:Cell Adhesion; D015718:Fibrin Tissue Adhesive; D006041:Goats; D006801:Humans; D009842:Oligopeptides; D011108:Polymers; D013696:Temperature
D015718:Fibrin Tissue Adhesive; D009842:Oligopeptides; D011108:Polymers; C047981:arginyl-glycyl-aspartic acid