title: Lymphocyte and neutrophil dysfunction associated with hepatitis B virus and hepatitis non-A, non-B virus infection in the chimpanzee.
abstract: Chimpanzees were examined for the effect of viral hepatitis infections on specific and nonspecific immune response mechanisms. The data suggest that infection with either hepatitis B virus or hepatitis non-A, non-B virus may result in suppression of cellular immune response components. Mitogen-induced lymphocyte proliferation was lower in virus-infected chimpanzees than in naive animals. Neutrophils from virus infected animals exhibited decreased or altered chemiluminescence kinetics.
authors.affiliation: Ohio State University, Center for Retrovirus Research, Columbus.
authors.forename: L J
authors.initials: LJ
authors.lastname: Lafrado
authors.forename: M A
authors.initials: MA
authors.lastname: Javadian
authors.forename: J M
authors.initials: JM
authors.lastname: Marr
authors.forename: K A
authors.initials: KA
authors.lastname: Wright
authors.forename: J C
authors.initials: JC
authors.lastname: Kelliher
authors.forename: C S
authors.initials: CS
authors.lastname: Dezzutti
authors.forename: L
authors.initials: L
authors.lastname: Cummins
authors.forename: R G
authors.initials: RG
authors.lastname: Olsen
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood; D006509:Hepatitis B / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D006526:Hepatitis C / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D006524:Hepatitis, Viral, Animal / Q000097:blood / Q000276:immunology*; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008863:Microspheres; D009504:Neutrophils / Q000276:immunology; D002679:Pan troglodytes
chemical_list: D002118:Calcium