Single photon emission computed tomography (SPECT) in cerebellar disease: cerebello-cerebral diaschisis.
Single photon emission computed tomography assessments were conducted in normal controls (n = 25), patients with unilateral cerebellar infarctions (n = 4), patients with olivopontocerebellar atrophy (OPCA; n = 15) and patients with Friedreich's ataxia (FA; n = 6). In subjects with unilateral cerebellar infarctions, crossed cerebellar-cortical diaschisis was observed: reduced cerebellar hexamethylpropyleneamine oxime (HMPAO) uptake was invariably accompanied by a diminution of HMPAO in the contralateral basal ganglia and frontoparietal cortex. OPCA and FA patients had various degrees of decreased HMPAO uptake in both the cerebellum and cerebral hemispheres.
Botez
M I
MI
Neurology Service, Hôtel-Dieu de Montréal, Canada.
Léveillé
J
J
Lambert
R
R
Botez
T
T
D000328:Adult; D000368:Aged; D001284:Atrophy; D002524:Cerebellar Ataxia / Q000000981:diagnostic imaging; D002531:Cerebellum / Q000098:blood supply* / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging*; D004292:Dominance, Cerebral / Q000502:physiology*; D005260:Female; D005621:Friedreich Ataxia / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply*; D009460:Neurologic Examination; D009849:Olivopontocerebellar Atrophies / Q000000981:diagnostic imaging*; D012039:Regional Blood Flow / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon