Site-specific recombination in the immune system.
Site-specific DNA recombination has been identified in a wide variety of biological systems. In vertebrates, however, the only identified use of this genetic device is in the immune system. Here it plays a critical role in generating a diverse repertoire of surface receptors to intercept invading microbes and parasites. The mechanism and orchestration of this reaction are intriguing and are relevant to a broad array of related biological and biomedical issues.
Lieber
M R
MR
Department of Pathology, Stanford University School of Medicine, California 94305-5324.
D000818:Animals; D001483:Base Sequence; D015321:Gene Rearrangement; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D011995:Recombination, Genetic
D007135:Immunoglobulin Variable Region