title: Dietary antigen handling by mother and offspring.
abstract: Sows were fed ovalbumin (OvA) as a novel protein antigen either throughout gestation and lactation (G + L) or during lactation only (L). This resulted in a significant uptake of OvA into blood, colostrum and milk along with a specific IgG response. In piglets from the G + L group, OvA and antibodies to OvA were detected in serum after ingestion of colostrum. In a large proportion of these piglets OvA was still detected at 3 weeks of age. In the L group a significant proportion of the piglets responded to OvA whilst still suckling their mother. At 3 weeks of age all piglets were weaned onto an egg-based diet. A similar uptake of OvA was seen in all piglets but there was no response to OvA in the G + L piglets. In piglets from sows fed only during lactation, however, a rapid IgG anti-OvA response and signs of diarrhoea were seen. The results suggest that factors of immunological importance are passed over from mother to offspring and it is proposed that immunological experience of dietary antigens by the mother is important for a 'safe' tolerance induction in her offspring.
authors.affiliation: Department of Veterinary Medicine, University of Bristol, School of Veterinary Science, Langford, Avon, UK.
authors.forename: E
authors.initials: E
authors.lastname: Telemo
authors.forename: M
authors.initials: M
authors.lastname: Bailey
authors.forename: B G
authors.initials: BG
authors.lastname: Miller
authors.forename: C R
authors.initials: CR
authors.lastname: Stokes
authors.forename: F J
authors.initials: FJ
authors.lastname: Bourne
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000917:Antibody Formation; D003126:Colostrum / Q000276:immunology; D004032:Diet; D005260:Female; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000032:analysis; D010047:Ovalbumin / Q000276:immunology*; D013552:Swine
chemical_list: D007074:Immunoglobulin G; D010047:Ovalbumin