title: Partial trisomy 1q. A nonrandom primary chromosomal abnormality in myelodysplastic syndromes?
abstract: Cytogenetic and clinical data of 11 patients with de novo myelodysplastic syndromes and partial or total trisomy of the long arm of chromosome 1 are presented. In eight of these patients trisomy 1q was the sole karyotypic change and therefore can be classified as a primary chromosome anomaly. A remarkably young median age of 36.5 years was noticed in this patient group.
authors.affiliation: Institut für Humangenetik, Medizinische Universität zu Lübeck, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Fonatsch
authors.forename: D
authors.initials: D
authors.lastname: Haase
authors.forename: M
authors.initials: M
authors.lastname: Freund
authors.forename: H
authors.initials: H
authors.lastname: Bartels
authors.forename: H
authors.initials: H
authors.lastname: Tesch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000754:Anemia, Refractory, with Excess of Blasts / Q000235:genetics; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014314:Trisomy