Induction of multiple follicular development and superovulation in the olive baboon, Papio anubis.
The objective of this study was to induce multiple follicular development and superovulation in the olive baboon. Beginning at menses, adult female baboons were treated with hMG for 10 days followed by hCG on day 11. Multiple follicular development was seen in all 19 animals; superovulation occurred in 11 of these. Serum E2 and P levels were consistent with multiple follicular and corpora lutea development, respectively. Ovulated ova were able to be fertilized. These results indicate that olive baboons can be superovulated using a regimen of hMG and hCG, however, development of antibodies against the human hormones precludes restimulation.
McCarthy
T J
TJ
Biologic Resources Laboratory, University of Illinois, Chicago.
Fortman
J D
JD
Boice
M L
ML
Fazleabas
A T
AT
Verhage
H G
HG
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D005306:Fertilization; D008596:Menotropins / Q000494:pharmacology*; D008954:Models, Biological; D006080:Ovarian Follicle / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction / Q000662:veterinary; D010215:Papio / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D013480:Superovulation
D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol; D008596:Menotropins