title: Effects of intraamygdaloid injection of taurine and valyltaurine on amygdaloid kindled seizure in rats.
abstract: Antiepileptic effects of intracerebral injections of taurine and valyltaurine were examined in amygdaloid kindled rats. The effects were assessed whether the animals can evoke generalized seizures by a 10 microA higher stimulation intensity than triggering thresholds. In all fully-kindled animals that have received intraamygdaloid injection of 500 nmol taurine, the kindled seizure was completely abolished. Such a significant seizure suppression (p less than 0.05) was observed 12-24 h after the taurine injection. Valyltaurine (500 nmol) also suppressed the seizure in 60% of animals tested, but the effect was not statistically significant. The results indicate that taurine may effectively suppress epileptic seizures when it acts directly at the stimulation site amygdala.
authors.affiliation: Miyazaki Mental Saga Hospital, Kyoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Uemura
authors.forename: K
authors.initials: K
authors.lastname: Ienaga
authors.forename: K
authors.initials: K
authors.lastname: Higashiura
authors.forename: H
authors.initials: H
authors.lastname: Kimura
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D004151:Dipeptides / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D007267:Injections; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000494:pharmacology*
chemical_list: D004151:Dipeptides; D013654:Taurine