Isolation of a stimulatory system in an Aloe extract.
The authors' previous work on a 50% ethanol extract of Aloe vera was done to evaluate anti-inflammatory activity using the croton oil-induced ear swelling assay. The anti-inflammatory activity was found in the supernatant fraction. The supernatant fraction decreased inflammation, when applied topically, by 29.2%, and the precipitate decreased inflammation by 12.1%. However, in the present work, the precipitate fraction decreased the wound diameter by an average of 47.1% (stimulatory system). Little or no wound healing activity was found in the supernatant. Aloe vera appears to act as a modulatory system toward wounds and inflammation and is a potentially valuable tool for managing lower extremity conditions.
Davis
R H
RH
Pennsylvania College of Podiatric Medicine, Philadelphia 19107.
Parker
W L
WL
Samson
R T
RT
Murdoch
D P
DP
D000328:Adult; D000504:Aloe; D000818:Animals; D000893:Anti-Inflammatory Agents; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D011134:Polysaccharides; D000431:Ethanol