title: Deficiencies in factors IX and VIII: what is now known.
abstract: Genetic defects both gross and subtle have recently been identified in about 900 patients with hemophilia A or B. The defects, which include deletions, insertions, and point mutations, reveal much about genetic structure-function relationships in hemophilia. These insights will lead to improved treatment of bleeding disorders and perhaps to their cure.
authors.affiliation: University of Michigan, Ann Arbor.
authors.forename: K
authors.initials: K
authors.lastname: Kurachi
authors.forename: S N
authors.initials: SN
authors.lastname: Yao
authors.forename: M
authors.initials: M
authors.lastname: Furukawa
authors.forename: S
authors.initials: S
authors.lastname: Kurachi
mesh_terms: D001483:Base Sequence; D002869:Chromosome Aberrations; D005164:Factor IX / Q000235:genetics; D005169:Factor VIII / Q000235:genetics; D015316:Genetic Therapy; D006467:Hemophilia A / Q000235:genetics* / Q000628:therapy; D002836:Hemophilia B / Q000235:genetics* / Q000628:therapy; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation
chemical_list: D005169:Factor VIII; D005164:Factor IX