Enhancement of MHC class II antigen expression by exposure to Candida albicans.
In oral infections with the yeast Candida albicans, the expression of MHC class II antigens on keratinocytes has been reported to be enhanced. In the present experiments, exposure to C. albicans or its products in vitro was found to increase the expression of class II MHC antigens on thioglycollate-induced mouse macrophages, and on LK cells (an antigen-presenting cell line). The implications of this finding for the understanding of immunoregulation and susceptibility to C. albicans infection are discussed.
Ashman
R B
RB
Pathology Department, University of Western Australia, Queen Elizabeth II Medical Centre, Nedlands.
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology*; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II