title: [Immunohistochemical features of nephrotoxic serum nephritis in the rat: the role of interleukin-1 in the development of heterologous and autologous stages].
abstract: Late heterologous and autologous stages of serum nephritis together with glomerular cells in culture are studied biochemically, morphologically and immunohistochemically for the assessment of the role of mononuclear leucocyte mediator system. The heterologous stage of the nephrotoxic nephritis is associated with the increase of Interleukin-I and TxA2 production. Role of Interleukin-I in the autologous stage is less pronounced in spite of proliferative activity of cultured mesangial cells. The effect of suppressive factors prevails in the glomerulus.
authors.forename: A A
authors.initials: AA
authors.lastname: Ivanov
authors.forename: E M
authors.initials: EM
authors.lastname: Shilov
authors.forename: O P
authors.initials: OP
authors.lastname: Gladskikh
authors.forename: O V
authors.initials: OV
authors.lastname: Gabrilevskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Nikiforova
authors.forename: M A
authors.initials: MA
authors.lastname: Pal'tsev
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000502:physiology*; D008297:Male; D009393:Nephritis / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013928:Thromboxane A2 / Q000096:biosynthesis
chemical_list: D007375:Interleukin-1; D013928:Thromboxane A2
vernacular_title: Immunogistokhimicheskaia kharakteristika nefrotoksicheskogo syvorotochnogo nefrita u krys: rol' interleĭkina-1 v razvitii geterologichnoĭ i autologichnoĭ faz.