title: Rps4 maps near the inactivation center on the mouse X chromosome.
abstract: RPS4Y, a Y-linked gene in humans, appears to encode an isoform of ribosomal protein S4. A homologous locus on the human X chromosome, RPS4X, lies close to the X-inactivation center but fails to undergo X-inactivation. We have isolated a genomic clone from the mouse Rps4 locus, the homolog of human RPS4X. We derived an intron probe that hybridizes to the functional Rps4 locus but does not cross-hybridize to related sequences elsewhere in the mouse genome. Genetic mapping utilizing interspecific mouse backcrosses and the intron-specific probe demonstrates that Rps4 maps close to the Phka locus on the mouse X chromosome and in the vicinity of the X-inactivation center. The gene order Ccg-1-Rps4/Phka-Xist-Pgk-1 is conserved between mouse and human.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St. Mary's Hospital Medical School, London, United Kingdom.
authors.forename: R M
authors.initials: RM
authors.lastname: Hamvas
authors.forename: A
authors.initials: A
authors.lastname: Zinn
authors.forename: J T
authors.initials: JT
authors.lastname: Keer
authors.forename: E M
authors.initials: EM
authors.lastname: Fisher
authors.forename: P
authors.initials: P
authors.lastname: Beer-Romero
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
authors.forename: D C
authors.initials: DC
authors.lastname: Page
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D015342:DNA Probes; D004303:Dosage Compensation, Genetic; D005260:Female; D006801:Humans; D007438:Introns; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D012269:Ribosomal Proteins / Q000235:genetics*; D013045:Species Specificity; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D012269:Ribosomal Proteins; C031798:ribosomal protein S4