title: [The vaccination of children with allergic diseases with reduced doses of adsorbed DT-m anatoxin].
abstract: During a remission and drug therapy, 71 children suffering from allergic diseases were vaccinated with DT-M toxoid containing different dose of diphtheria (1, 2.5, 5 LF) and tetanus (1, 2.5, 5 EC) antigens. It has been shown that all the children responded to tetanus antigen by adequate serological tests, whereas as regards diphtheria toxoid, the patients immunized with the least dose of DT-M preparation (1 LF + + 1 EC antigens) produced specific antibodies later and at a lower level. During the postvaccinal period, they also manifested an increase of the content of IgE and exacerbation of the underlying disease in 17.8% of cases. The use of DT-M toxoid with 2.5 LF + EC antigens was shown to hold promise in vaccination of children suffering from allergic diseases.
authors.forename: M P
authors.initials: MP
authors.lastname: Kostinov
authors.forename: I I
authors.initials: II
authors.lastname: Balabolkin
authors.forename: N M
authors.initials: NM
authors.lastname: Maksimova
authors.forename: V B
authors.initials: VB
authors.lastname: Gervazieva
authors.forename: N A
authors.initials: NA
authors.lastname: Egor'kov
authors.forename: I G
authors.initials: IG
authors.lastname: Ovsiannikova
authors.forename: A N
authors.initials: AN
authors.lastname: Lobanova
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D002648:Child; D003017:Clostridium tetani / Q000276:immunology; D003353:Corynebacterium diphtheriae / Q000276:immunology; D004168:Diphtheria Toxoid / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D022422:Diphtheria-Tetanus Vaccine; D004306:Dose-Response Relationship, Immunologic; D004338:Drug Combinations; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000517:prevention & control*; D007114:Immunization / Q000379:methods; D007115:Immunization Schedule; D007117:Immunization, Secondary; D013745:Tetanus Toxoid / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D004338:Drug Combinations; D013745:Tetanus Toxoid
vernacular_title: Vaktsinatsiia deteĭ s allergicheskimi zabolevaniiami umen'shennymi dozami ADS-M-anatoksina.