[Clinical evaluation of serological antigen detection tests for candidemia].
The new serological tests for candidemia were evaluated. In nine cases of candidemia, fungal index (Endotoxin D-Endospecy) was 146.8 +/- 116.8 pg/ml and D-arabinitol/creatinine 1.10 +/- 1.04 mumol/mg. Fungal index was significantly (p less than 0.01) higher in candidemia than suspected infections. All candidemia were positive for Cand-Tec latex agglutination, but twelve of the sixteen cases of suspected infections were also positive. Mannan latex agglutination was very specific for candidemia. Four cases of candidemia was positive for Mannan latex agglutination and only one case was positive in suspected infections. Fungal index and D-arabinitol/creatinine was decreased after treatment of antifungal agents. In poor clinical efficacy case, these titer remained high even after treatment. These data suggested the usefulness of these serological tests for candidemia.
Maesaki
S
S
2nd Department of Internal Medicine, School of Medicine, Nagasaki University.
Kohno
S
S
Yamada
H
H
Mitsutake
K
K
Sugiyama
H
H
Hori
H
H
Kaku
M
M
Koga
H
H
Hara
K
K
Seto
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000946:Antigens, Fungal / Q000032:analysis*; D002175:Candida / Q000276:immunology; D002177:Candidiasis / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D016469:Fungemia / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D007841:Latex Fixation Tests; D008297:Male; D008875:Middle Aged; D012698:Serologic Tests
D000946:Antigens, Fungal