Side effects during long-term treatment with depot antipsychotic medication.
During long-term treatment of schizophrenia with antipsychotic medication, side effects such as weight gain and tardive dyskinesia may develop, while other extrapyramidal side effects may continue. A large multicenter, double-blind, comparative trial of haloperidol decanoate and fluphenazine decanoate has been completed, in which 181 patients took part. The study lasted for 1 year and patients were assessed using the Krawiecka scale, the Montgomery-Asberg scales for schizophrenia and depression, the Simpson-Angus scale for parkinsonism, the AIMS for tardive dyskinesia, and a scale for akathisia. Patients were also weighed at each assessment. The results provide further evidence about the occurrence of weight changes, extrapyramidal side effects, and depression during long-term treatment and about the relative benefits of the two treatments.
Cookson
J C
JC
Joint Academic Unit of Human Psychopharmacology, Royal London Hospital, England.
D017109:Akathisia, Drug-Induced; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology; D005476:Fluphenazine / Q000009:adverse effects / Q000627:therapeutic use; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced; D011595:Psychomotor Agitation / Q000503:physiopathology; D012008:Recurrence; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*
D003692:Delayed-Action Preparations; C033563:haloperidol decanoate; D006220:Haloperidol; D005476:Fluphenazine