Twenty-nail dystrophy associated with hematologic abnormalities.
This report describes a 15 1/2 year old white male with twenty-nail dystrophy who has had recurrent episodes of immune thrombocytopenic purpura, autoimmune hemolytic anemia, and mild depression of immunoglobulin levels. The concurrence of these events suggests that each shares a common pathophysiologic mechanism, possibly an autoimmune process.
Germain-Lee
E L
EL
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Zinkham
W H
WH
D000293:Adolescent; D000367:Age Factors; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004406:Dysgammaglobulinemia / Q000150:complications*; D006801:Humans; D017099:IgG Deficiency; D008297:Male; D009260:Nail Diseases / Q000175:diagnosis / Q000209:etiology*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000276:immunology; D013997:Time Factors