Apolipoprotein E phenotypes and hyperlipidemia in patients under maintenance hemodialysis.
Apolipoprotein E phenotypes and gene frequencies were determined in 560 patients receiving long-term hemodialysis. In addition, fasting plasma lipid- and apolipoprotein-concentrations were evaluated in 245 of these individuals. The distribution of the three major apolipoprotein E alleles (epsilon 4, epsilon 3, and epsilon 2) and that of the six common apolipoprotein E phenotypes (E4/4, E3/3, E2/2, E4/2, E4/3, and E3/2) in the dialysis group was nearly identical to that of healthy controls. Patients with the apolipoprotein E phenotypes E2/2, E4/4 and E4/3 (comprising 24% of the whole group) had higher mean plasma cholesterol- and triglyceride-concentrations than those with the apolipoprotein E phenotypes E3/3 and E3/2 (72% of the whole group). Thus, the genetic polymorphism of apolipoprotein E may contribute to the individual risk of accelerated atherosclerosis in patients under maintenance hemodialysis.
Feussner
G
G
Abteilung Innere Medizin I, Universität Heidelberg, Federal Republic of Germany.
Wey
S
S
Bommer
J
J
Deppermann
D
D
Grützmacher
P
P
Ziegler
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000235:genetics*; D007676:Kidney Failure, Chronic / Q000628:therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D006435:Renal Dialysis
D001057:Apolipoproteins E; D008055:Lipids