title: [The current concepts of the effect of cardiac glycosides on sinus node function and atrioventricular conductivity].
abstract: The clinical aspects of the influence of cardiac glycosides on the sinus node and atrioventricular junction in health and dysfunction are reviewed. It has been shown that digitalis drugs do not produce any effect on sinus node automatism including that in dysfunction. Cardiac glycosides suppress enhanced atrioventricular conduction and do not affect it provided it remains within normal. The mechanisms by which cardiac glycosides may act are discussed: extracardiac, cholinomimetic (in the acute test and direct one) and influencing heart conduction components (when used continuously).
authors.forename: V A
authors.initials: VA
authors.lastname: Bobrov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Shchepotin
mesh_terms: D002301:Cardiac Glycosides / Q000494:pharmacology* / Q000627:therapeutic use; D006327:Heart Block / Q000188:drug therapy; D006329:Heart Conduction System / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D012849:Sinoatrial Node / Q000187:drug effects* / Q000502:physiology
chemical_list: D002301:Cardiac Glycosides
vernacular_title: Sovremennye predstavleniia o vliianii serdechnykh glikozidov na funktsiiu sinusovogo uzla i atrioventrikuliarnuiu provodimost'.