Intracellular signaling by 14-hydroxy-4,14-retro-retinol.
In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.
Buck
J
J
Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Derguini
F
F
Levi
E
E
Nakanishi
K
K
Hämmerling
U
U
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D002460:Cell Line; D004224:Diterpenes; D006133:Growth Substances; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D012176:Retinoids / Q000737:chemistry*; D015290:Second Messenger Systems; D015398:Signal Transduction; D013056:Spectrophotometry, Ultraviolet; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000737:chemistry / Q000502:physiology
D004224:Diterpenes; D006133:Growth Substances; D012176:Retinoids; D014801:Vitamin A; C072014:14-hydroxy-4,14-retro-retinol