SPUU-PEO-heparin graft copolymer surfaces. Patency and platelet deposition in canine small diameter arterial grafts.
The influence of an SPUU-PEO-Heparin (B-PEO-HEP) copolymer coated blood contacting surface on patency and platelet deposition in small diameter (4 mm i.d.) Biomer grafts was investigated using a canine model. Grafts were implanted in the bilateral carotid and femoral arteries. B-PEO-HEP coated grafts still showed patency after 3 days. Control Biomer grafts occluded before 24 hr. (postoperatively). SEM of the luminal surfaces of the Biomer grafts demonstrated large amounts of adherent platelets with distorted morphologies, while B-PEO-HEP grafts did not. In platelet studies, B-PEO-HEP grafts showed significantly less platelet adhesion than Biomer grafts. The improved blood compatibility of B-PEO-HEP graft co-polymer coatings attests to their usefulness for coating or casting.
Kim
W G
WG
Department of Pharmaceutics/CCCD, Salt Lake City, UT 84108.
Park
K D
KD
Mohammad
S F
SF
Kim
S W
SW
D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D004285:Dogs; D006083:Graft Occlusion, Vascular / Q000097:blood*; D006493:Heparin; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness / Q000502:physiology*; D011092:Polyethylene Glycols; D011108:Polymers; D011140:Polyurethanes; D013499:Surface Properties
D001672:Biocompatible Materials; D011108:Polymers; D011140:Polyurethanes; D011092:Polyethylene Glycols; C031892:biomer; D006493:Heparin