[Metabolic function of isolated liver mitochondria during various conditions of vitamin D and K supply and administration of pelentane].
Alimentary deficiency of vitamin K caused a decrease in the rate of respiration in presence of ADP and in the rate of oxidative phosphorylation in the presence of succinate. Administration of the antivitamin K pelentane, excess of vikasol and deficiency of vitamin D did not affect these parameters. As distinct from controls and rats treated with pelentane, transport of calcium was decreased in presence of all the substrates studied in mitochondria isolated from liver tissue of animals deprived of vitamins K and D as well as of animals treated with vikasol excess. At the same time, accumulation of calcium led to time-dependent inhibition of respiratory chain if NAD-dependent substrates were used. Possible reasons of dissimilarity observed are discussed; the phenomenon found may occur due to exhaustion of the mitochondrial pyridine nucleotides pool. The data obtained suggest that antivitamins K altered only some parameters of body status (prothrombin time) similarly to the alterations observed in alimentary deficiency of vitamin K.
Tiulina
O V
OV
Sokol'nikov
A A
AA
Zharova
T V
TV
Kodentsova
V M
VM
Leĭkin
Iu N
IuN
Spirichev
V B
VB
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005017:Ethyl Biscoumacetate / Q000494:pharmacology*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D014808:Vitamin D Deficiency / Q000378:metabolism*; D014812:Vitamin K / Q000031:analogs & derivatives / Q000494:pharmacology; D024483:Vitamin K 3; D014813:Vitamin K Deficiency / Q000378:metabolism*
D005017:Ethyl Biscoumacetate; D014812:Vitamin K; D024483:Vitamin K 3; D002118:Calcium
Metabolicheskie funktsii izolirovannykh mitokhondriĭ pecheni pri razlichnoĭ obespechennosti krys vitaminami D i K i vvedenii pelentana.