title: Rhabdomyolysis associated with cranial diabetes insipidus.
abstract: Rhabdomyolysis has been reported to be associated with hyperosmolality in diabetic ketoacidosis and non-ketotic hyperosmolal state. Whether the rhabdomyolysis was due to hyperosmolality per se or whether hyperglycaemia also played a role is not clear. We hereby report a case of cranial diabetes insipidus with hypernatraemia and hyperosmolality complicated by rhabdomyolysis. None of the known risk factors, such as coma, hypokalaemia, hypophosphataemia, diabetic ketoacidosis or non-ketotic hyperosmolality, were present in this patient. We believe that severe hyperosmolality per se is an important predisposing factor for non-traumatic rhabdomyolysis, and serum muscle enzymes should be closely monitored in the management of patients with diabetes insipidus.
authors.affiliation: Department of Medicine, Queen Mary Hospital, University of Hong Kong.
authors.forename: A W
authors.initials: AW
authors.lastname: Kung
authors.forename: K K
authors.initials: KK
authors.lastname: Pun
authors.forename: K S
authors.initials: KS
authors.lastname: Lam
authors.forename: R T
authors.initials: RT
authors.lastname: Yeung
mesh_terms: D000328:Adult; D001928:Brain Diseases, Metabolic / Q000150:complications; D003919:Diabetes Insipidus / Q000150:complications*; D006801:Humans; D006955:Hypernatremia / Q000150:complications*; D008297:Male; D009994:Osmolar Concentration; D012206:Rhabdomyolysis / Q000209:etiology*