title: From linked marker to gene.
abstract: An area of increasing importance in human genetics research is the strategy of 'reverse genetics' or 'positional cloning', whereby a gene associated with a genetic disease is isolated on the basis of its approximate chromosomal position. This article and the accompanying centrepage diagram describe the main features of this strategy and outline the techniques involved; they are designed to be used for teaching purposes and as a general reference for those from other fields of genetics research.
authors.affiliation: Department of Biochemistry and Molecular Genetics, St Mary's Hospital, Medical School, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Wicking
authors.forename: B
authors.initials: B
authors.lastname: Williamson
mesh_terms: D002874:Chromosome Mapping; D003001:Cloning, Molecular; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*
chemical_list: D005819:Genetic Markers