title: Quantitation of proteinuria using protein-creatinine ratio in random urine samples.
abstract: Estimation of proteinuria in children is cumbersome when a 24 h urine collection is needed. In the presence of a stable glomerular filtration rate, the ratio of urinary protein and creatinine should reflect the protein excretion. One hundred samples of urine (24 h and random samples) were collected from 50 children with nephrotic syndrome, 25 with nephrotic syndrome in remission and 25 normal children. The 24 h urine total protein and random urine protein-creatinine ratio were assessed on these samples. Linear regression analysis of the results showed excellent correlation between the values (r = 0.81, p less than 0.001). A random urine protein-creatinine ratio of greater than 3.5 correlated with massive proteinuria, while a ratio less than 0.2 was suggestive of physiological values. The sensitivity, specificity, positive and negative predictive values of the protein-creatinine ratio in massive proteinuria were very high. We conclude that the random urine protein-creatinine ratio can be used reliably to assess the degree of proteinuria in children.
authors.affiliation: Department of Pediatrics, Kasturba Medical College, Manipal, Kamataka.
authors.forename: R S
authors.initials: RS
authors.lastname: Iyer
authors.forename: S N
authors.initials: SN
authors.lastname: Shailaja
authors.forename: N
authors.initials: N
authors.lastname: Bhaskaranand
authors.forename: M
authors.initials: M
authors.lastname: Baliga
authors.forename: A
authors.initials: A
authors.lastname: Venkatesh
mesh_terms: D002648:Child; D002940:Circadian Rhythm / Q000502:physiology; D003404:Creatinine / Q000652:urine*; D005188:False Negative Reactions; D006801:Humans; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000652:urine*; D011507:Proteinuria / Q000175:diagnosis*; D012016:Reference Values; D012044:Regression Analysis; D013048:Specimen Handling / Q000379:methods
chemical_list: D003404:Creatinine