title: Mammalian sex chromosomes. III. Activity of pseudoautosomal steroid sulfatase enzyme during spermatogenesis in Mus musculus.
abstract: Parallel to the inactivation of the X chromosome in somatic cells of female, the male X in mammals is rendered inactive during spermatogenesis. Pseudoautosomal genes, those present on the X-Y meiotically pairable region of male, escape inactivation in female soma. It is suggested, but not demonstrated, that they may also be refractory to the inactivation signal in male germ cells. We have assayed activity of the enzyme steroid sulfatase, product of a pseudoautosomal gene, in testicular cells of the mouse and shown its presence in premeiotic, meiotic (pachytene), and postmeiotic (spermatid) cell types. It appears that, as in females, pseudoautosomal genes may escape inactivation in male germ cells also.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varanasi, India.
authors.forename: R
authors.initials: R
authors.lastname: Raman
authors.forename: P
authors.initials: P
authors.lastname: Das
mesh_terms: D000818:Animals; D001192:Arylsulfatases / Q000235:genetics*; D001853:Bone Marrow / Q000201:enzymology; D004303:Dosage Compensation, Genetic; D005260:Female; D008099:Liver / Q000201:enzymology; D008297:Male; D008540:Meiosis / Q000235:genetics; D051379:Mice; D013087:Spermatids / Q000201:enzymology*; D013090:Spermatocytes / Q000201:enzymology*; D013091:Spermatogenesis / Q000235:genetics*; D043266:Steryl-Sulfatase; D014960:X Chromosome / Q000502:physiology*
chemical_list: D001192:Arylsulfatases; D043266:Steryl-Sulfatase