Hyperlipidemia associated with alpha-mercaptopropionylglycine therapy for cystinuria.
Treatment of cystinuria with alpha-mercaptopropionylglycine has been associated with fewer side effects than traditional therapy with D-penicillamine. In this report, we describe a patient who developed hyperlipidemia secondary to alpha-mercaptoproprionylglycine therapy. This abnormality resolved after the therapy was discontinued and did not recur with lower dose therapy. Patients treated with alpha-mercaptoproprionylglycine should be monitored closely for the development of lipid abnormalities.
Siskind
M S
MS
Department of Internal Medicine, University of Arizona College of Medicine, Tucson 85724.
Popovtzer
M M
MM
D000328:Adult; D003555:Cystinuria / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced*; D008625:Tiopronin / Q000009:adverse effects* / Q000627:therapeutic use
D008625:Tiopronin