title: Evidence against the hypothesis that hyperinsulinemia increases sympathetic nervous system activity in man.
abstract: To test the hypothesis that physiologic hyperinsulinemia activates the sympathetic nervous system in humans, we measured changes in plasma norepinephrine as well as epinephrine concentrations during euglycemic hyperinsulinemic clamp experiments in which normal volunteers were infused with insulin for up to 12 hours, at rates chosen to simulate the basal and postprandial hyperinsulinemia seen in insulin-resistant states. Infusions of insulin increased plasma insulin threefold (to approximately 200 pmol/L) and 15-fold (to approximately 1,000 pmol/L) in simulations of fasting and postprandial hyperinsulinemia. In neither experiment did plasma norepinephrine or epinephrine change significantly. In control experiments in which saline was infused for 12 hours, plasma epinephrine increased twofold (P less than .05), but plasma norepinephrine did not change. Therefore, we conclude that hyperinsulinemia of the magnitude seen in the insulin-resistant humans does not increase sympathetic nervous system activity.
authors.affiliation: Department of Medicine and Physiology, University of Pittsburgh, School of Medicine, PA.
authors.forename: A
authors.initials: A
authors.lastname: Mitrakou
authors.forename: M
authors.initials: M
authors.lastname: Mokan
authors.forename: G
authors.initials: G
authors.lastname: Bolli
authors.forename: T
authors.initials: T
authors.lastname: Veneman
authors.forename: T
authors.initials: T
authors.lastname: Jenssen
authors.forename: P
authors.initials: P
authors.lastname: Cryer
authors.forename: J
authors.initials: J
authors.lastname: Gerich
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004435:Eating / Q000502:physiology; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology*; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D009638:Norepinephrine / Q000097:blood*; D012016:Reference Values; D013564:Sympathetic Nervous System / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009638:Norepinephrine; D004837:Epinephrine