The excretion and characterization of intravenously administered olestra.
Although sucrose octaoleate that is consumed is neither digested or absorbed, following intravenous injection it is found mainly in the liver. Olestra is a mixture of the hexa-, hepta-, and octaesters of sucrose. To follow the metabolic fate of intravenously administered [14C]sucrose-labeled olestra, we measured its urinary elimination, and the rate of excretion of 14C in the feces, and characterized the 14C-labeled material that appeared in bile. The fecal excretion for days 4-14 after dosing was found to be first order with the half-life of the injected olestra being 5.0 +/- 0.5 days. The 14C recovered in the bile was soluble in chloroform. Two-dimensional thin-layer chromatography autoradiograms of the biliary lipid showed the pattern of the biliary 14C to be essentially the same as that of the dosed olestra. Biliary excretion and subsequent fecal egestion of essentially unhydrolyzed sucrose esters is the principal route for the removal of intravenously administered olestra. Only traces of 14C were found in the urine.
Jandacek
R J
RJ
Miami Valley Laboratories, Procter and Gamble Company, Cincinnati, Ohio 45239-8707.
Holcombe
B N
BN
D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D001345:Autoradiography; D001646:Bile / Q000737:chemistry*; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000378:metabolism* / Q000494:pharmacology / Q000652:urine*; D005243:Feces / Q000737:chemistry*; D007275:Injections, Intravenous; D007553:Isotope Labeling; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D051381:Rats; D013154:Spleen / Q000737:chemistry; D013395:Sucrose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000652:urine; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D005227:Fatty Acids; D013395:Sucrose; C013692:sucrose polyester