Magnetic resonance imaging of body fat of athletes compared with controls, and the oxidative metabolism of estradiol.
The extent of 2-hydroxylation of estradiol (E2), which yields a non-estrogenic metabolite (2-OHE1), increased significantly with decreasing subcutaneous fat (ScF)/total volume percent (TV%) and total fat (TF)/TV% evaluated by magnetic resonance imaging (MRI) for five athletes during low- and high-intensity training, and four controls. The increase in 2-hydroxylation with decreasing adiposity was associated with anovulation and amenorrhea among the athletes.
Frisch
R E
RE
Harvard Center for Population Studies, Cambridge, MA 02138.
Snow
R
R
Gerard
E L
EL
Johnson
L
L
Kennedy
D
D
Barbieri
R
R
Rosen
B R
BR
D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000378:metabolism; D000328:Adult; D001835:Body Weight; D004958:Estradiol / Q000378:metabolism*; D015444:Exercise; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008279:Magnetic Resonance Imaging; D012016:Reference Values; D013177:Sports
D004958:Estradiol