Analgesia by nefopam: does it act through serotonin?
In an attempt to clarify the possible mode of action of nefopam, a new analgesic compound, the authors tested its effects on imipramine (IMI) binding to platelet membranes. The results showed that nefopam exerted a concentration-dependent inhibition of IMI binding, with a potency comparable to that of tricyclic antidepressants. This finding suggests a possible intervention of serotonergic mechanisms in nefopam-related analgesia.
Marazziti
D
D
Institute of the Psychiatric Clinic, University of Pisa, Italy.
Rotondo
A
A
Ambrogi
F
F
Cassano
G B
GB
D000698:Analgesia; D001792:Blood Platelets / Q000187:drug effects; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007099:Imipramine / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D009020:Morphine / Q000494:pharmacology; D009340:Nefopam / Q000494:pharmacology*; D009966:Orphenadrine / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*
D012702:Serotonin Antagonists; D009340:Nefopam; D009020:Morphine; D009966:Orphenadrine; D007099:Imipramine; D003891:Desipramine