[The effect of leukinferon on the activity of phagocytosing cells in human salmonellosis].
The functional activity of phagocytic cells in 52 salmonellosis patients was studied with regard to the following characteristics: percent share of phagocytosis, phagocytic index, nitro blue tetrazolium test results, digestive activity. In patients with the unfavorable course of salmonellosis (the formation of carrier state) disturbances in the bactericidal activity of neutrophils and monocytes were established. For 32 patients leukinferon was included in the complex of etiotropic and pathogenetic treatment. The preparation was introduced in 3 intramuscular injections of 10,000 I. U. at intervals of 48 hours (the course of treatment); 10 days after the last injection this course was repeated. The use of leukinferon restored the normal functioning of phagocytes and the number of T-lymphocytes.
Zueva
V S
VS
Spivak
N Ia
NIa
Fil'chakov
I V
IV
Kuznetsov
V P
VP
Bratus'
E V
EV
D000293:Adolescent; D000328:Adult; D001770:Blood Bactericidal Activity / Q000187:drug effects; D016207:Cytokines / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009580:Nitroblue Tetrazolium; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D012480:Salmonella Infections / Q000276:immunology / Q000628:therapy*; D012477:Salmonella enteritidis; D012486:Salmonella typhimurium; D014435:Typhoid Fever / Q000276:immunology / Q000628:therapy*
D016207:Cytokines; D004338:Drug Combinations; D007370:Interferon Type I; C062252:leukinferon; D009580:Nitroblue Tetrazolium
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