The measurement of nucleoside deaminases by high performance liquid chromatography and their use in clinical chemistry.
The measurement of the nucleoside deaminases--cytidine deaminase, guanosine deaminase and adenosine deaminase--by reversed phase high performance liquid chromatography is reviewed. The clinical value of assaying the enzyme activity is discussed for each of these enzymes. Both cytidine deaminase and adenosine deaminase measurements have proven clinical value, although the use of the assay of cytidine deaminase in the diagnosis of pre-eclampsia is probably not helpful.
Sherwood
R A
RA
Department of Clinical Biochemistry, Kings College School of Medicine and Dentistry, Denmark Hill, London, UK.
D000243:Adenosine Deaminase / Q000032:analysis; D000619:Aminohydrolases / Q000032:analysis; D002624:Chemistry, Clinical; D002851:Chromatography, High Pressure Liquid; D003564:Cytidine Deaminase / Q000032:analysis; D009700:Nucleoside Deaminases / Q000032:analysis*
D000619:Aminohydrolases; D009700:Nucleoside Deaminases; C040317:guanosine deaminase; D000243:Adenosine Deaminase; D003564:Cytidine Deaminase