title: In vitro and in vivo comparison of creams containing dithranol 0.5%.
abstract: In an in vitro model, the release and penetration through a silicon membrane of different cream formulations and ointments containing 0.5% dithranol were studied. The results indicated that the method is not suitable for predicting in vivo release and penetration. Experiments with rabbits showed that the degree of skin irritation produced by a hospital-prepared product containing 0.5% dithranol was comparable to that of of a commercial product. Clinical efficacy and side-effects of these two products were investigated in a double-blind left-right comparative study in 35 patients with chronic plaque psoriasis. The two creams proved to be equally effective and showed the same incidence of side-effects.
authors.affiliation: Hospital Pharmacy Gelderse Vallei, Bennekom, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Ros
authors.forename: Y G
authors.initials: YG
authors.lastname: Van der Meer
authors.forename: D
authors.initials: D
authors.lastname: De Hoop
authors.forename: W J
authors.initials: WJ
authors.lastname: De Kort
authors.forename: P
authors.initials: P
authors.lastname: Van Andel
mesh_terms: D000818:Animals; D000875:Anthralin / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007509:Irritants; D008297:Male; D009824:Ointments; D011565:Psoriasis / Q000188:drug therapy; D011817:Rabbits; D012995:Solubility
chemical_list: D007509:Irritants; D009824:Ointments; D000875:Anthralin