title: Anticancer gelatin microspheres with multiple functions.
abstract: Biodegradable, hydrophilic gelatin microspheres (GM) with an average diameter of 70 microns were prepared by cross-linking gelatin with glutaraldehyde for hepatic intra-arterial infusion. An anticancer agent, mitomycin C (MMC), together with a radioisotope, 131I, were bound to the GM for chemotherapy and local internal radiotherapy. The 131I-labelled MMC-GM (131I-MMC-GM) could accumulate in the specific site and embolize the hepatic arteries after the hepatic intra-arterial infusion, while it caused various effects to the liver cells. The 131I-MMC-GM remained within the hepatic arteries for at least one month. In vitro release of drugs from the GM was also quantified using a dynamic dialysis method.
authors.affiliation: Chengdu Institute of Organic Chemistry, Academia Sinica, Chengdu, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Yan
authors.forename: X W
authors.initials: XW
authors.lastname: Li
authors.forename: X L
authors.initials: XL
authors.lastname: Chen
authors.forename: D Q
authors.initials: DQ
authors.lastname: Wang
authors.forename: D C
authors.initials: DC
authors.lastname: Zhong
authors.forename: T Z
authors.initials: TZ
authors.lastname: Tan
authors.forename: H
authors.initials: H
authors.lastname: Kitano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials; D004285:Dogs; D016503:Drug Delivery Systems / Q000379:methods*; D005780:Gelatin; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D007457:Iodine Radioisotopes; D008863:Microspheres; D016685:Mitomycin / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D007457:Iodine Radioisotopes; D016685:Mitomycin; D005780:Gelatin