[Immunohistochemical expression of alpha-1-antitrypsin in human gliomas].
The present paper describes the analysis of immunostaining patterns of four antibodies, alpha-1-antitrypsin (alpha-AT), glial fibrillary acid protein (GFAP), S-100 protein (S-100), and vimentin in 31 human gliomas. The gliomas were 10 astrocytomas, 10 anaplastic astrocytomas, and 11 glioblastoma multiforme tumors. The immunoreactivity for vimentin and alpha-AT that is one of the main proteinase inhibitors changed in proportion to the degree of histological malignancy. As alpha-AT was localized mainly in the cytoplasm of tumor cells and partially in extracellular spaces, it was thought to have been derived from tumor cells. Preparations immunolabelled with anti-GFAP and anti-S-100 showed no increasing loss of immunoreactivity parallel with increasing malignancy.
Ikeyama
Y
Y
Department of Neurosurgery, Yamaguchi University School of Medicine.
Orita
T
T
Nishizaki
T
T
Aoki
H
H
Ito
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D014746:Vimentin; D000515:alpha 1-Antitrypsin