title: Differences in the hypoxic contraction of small isolated pulmonary arteries of cat and rabbit.
abstract: In small (less than 300 microns diameter) pulmonary arterial (PA) rings isolated from the cat, hypoxia induced a transient contraction (250 +/- 120 mg, n = 7), whereas in rings of rabbit PA of the same size, hypoxia had no significant effect (n = 19). Precontraction by 40 mmol KCl.1(-1), noradrenaline (NA) 10(-6) mol.1(-1), or histamine (His 10(-5) mol.1(-1)) did not modify this difference between the two species and did not potentiate the hypoxic contraction of small rings of the cat PA. Large rabbit pulmonary arterial segments (300-2000 microns) exhibited no response to hypoxia before precontraction (n = 15). In the presence of procaine (2%) rabbit PA rings (n = 6, small) exhibited no hypoxic contraction. These results in vitro reflect previous in vivo observations.
authors.affiliation: Laboratoire d'électrophysiologie et de pharmacologie cellulaires, Parc de Grandmont, Tours, France.
authors.forename: P
authors.initials: P
authors.lastname: Bonnet
authors.forename: J A
authors.initials: JA
authors.lastname: Argibay
authors.forename: E
authors.initials: E
authors.lastname: White
authors.forename: D
authors.initials: D
authors.lastname: Garnier
mesh_terms: D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology*; D009638:Norepinephrine / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D011343:Procaine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*
chemical_list: D011343:Procaine; D006632:Histamine; D010100:Oxygen; D009638:Norepinephrine