title: [Primary brain lymphoma].
abstract: Between 1973 and 1989, 739 patients with non-Hodgkin's lymphoma were referred here for treatment, of whom 10 (1.4%) had primary brain lymphoma (PBL) and 1 had acquired immunodeficiency syndrome (AIDS). There were 7 females and 3 males (mean age 58 years, range 35-77). Duration of symptoms ranged from several days to 3 weeks. The presenting symptoms were secondary to increased intracranial pressure. Computerized tomography (CT) performed in 8 revealed a solitary lesion in 7. Other CT scan features were various degrees of contrast enhancement, edema and midline shift. The most common site was the frontal lobe; infratentorially, the cerebellum was the most frequent site. The diagnosis was established in 8 patients by surgery and in 2 at autopsy. The most common subtype was the diffuse, large cell, immunoblastic lymphoma. 5 patients were irradiated following subtotal excision and 2 had combined radiation therapy and high-dose methotrexate-based chemotherapy; only 1 had no postoperative treatment. All patients treated by radiotherapy alone died within 3-5 months after diagnosis. The 2 who received combined therapy are alive, 15 and 48 months after diagnosis, respectively.
authors.affiliation: Northern Israel Oncology Center, Haifa.
authors.forename: M
authors.initials: M
authors.lastname: Stein
authors.forename: A
authors.initials: A
authors.lastname: Kuten
authors.forename: Y
authors.initials: Y
authors.lastname: Ben-Arieh
authors.forename: Y
authors.initials: Y
authors.lastname: Cohen
authors.forename: N
authors.initials: N
authors.lastname: Haim
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000601:surgery / Q000628:therapy; D008297:Male; D008875:Middle Aged