title: Pulmonary Aspergillus chest wall involvement in chronic granulomatous disease: CT and MRI findings.
abstract: Pulmonary Aspergillus infection in patients with chronic granulomatous disease tends to involve the chest wall and consequently carries a high mortality rate. We report the findings of computed tomography (CT) and magnetic resonance imaging (MRI) in three such cases. One patient underwent both CT and MRI, one, CT only, and one, MRI only. In all three, both CT and MRI demonstrated pulmonary consolidations with direct extension to the adjacent chest wall. In both patients who were examined by CT, scans revealed permeative osteolytic changes of adjacent rib or spine compatible with osteomyelitis. In both patients who were examined by MRI, adjacent chest wall involvement was depicted on T1-weighted images and showed increased signal intensity on T2-weighted images. In one of these patients, the chest wall lesion was well defined on T2-weighted images, an appearance compatible with abscess. Epidural extension was demonstrated on MRI in the other patient, who later developed paraparesis. We suggest that CT and MRI have a complementary role in evaluating chest wall invasion by pulmonary Aspergillus infection in chronic granulomatous disease.
authors.affiliation: Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland.
authors.forename: A
authors.initials: A
authors.lastname: Kawashima
authors.forename: J E
authors.initials: JE
authors.lastname: Kuhlman
authors.forename: E K
authors.initials: EK
authors.lastname: Fishman
authors.forename: C M
authors.initials: CM
authors.lastname: Tempany
authors.forename: D
authors.initials: D
authors.lastname: Magid
authors.forename: H M
authors.initials: HM
authors.lastname: Lederman
authors.forename: J A
authors.initials: JA
authors.lastname: Winkelstein
authors.forename: E A
authors.initials: EA
authors.lastname: Zerhouni
mesh_terms: D000293:Adolescent; D000328:Adult; D001228:Aspergillosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D006105:Granulomatous Disease, Chronic / Q000150:complications*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D013896:Thoracic Diseases / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed