title: Blood transfusion and lung function in children with thalassemia major.
abstract: Pulmonary function tests were performed at rest and following blood transfusion on 17 patients with thalassemia major. At rest, diffusion capacity was significantly reduced (mean of 57 percent), and forced vital capacity was mildly reduced (mean of 85 percent). In two of the patients, arterial oxygen tension was low. Other pulmonary function results were in the normal range. Following blood transfusion, a significant drop was seen in arterial oxygen tension (PaO2 of 22 mm Hg) and in forced vital capacity (FVC) of 32 percent. These changes were dramatic and require further explanation.
authors.affiliation: Institute of Pulmonary and Allergic Disease, Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Bacalo
authors.forename: S
authors.initials: S
authors.lastname: Kivity
authors.forename: N
authors.initials: N
authors.lastname: Heno
authors.forename: Z
authors.initials: Z
authors.lastname: Greif
authors.forename: J
authors.initials: J
authors.lastname: Greif
authors.forename: M
authors.initials: M
authors.lastname: Topilsky
mesh_terms: D000293:Adolescent; D001803:Blood Transfusion; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood; D011659:Pulmonary Gas Exchange; D015656:Respiratory Mechanics; D013789:Thalassemia / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D014797:Vital Capacity
chemical_list: D010100:Oxygen