The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.
The cDNA sequence for amyloid precursor protein and the two alternatively spliced forms were determined. Seven nucleotide differences resulting in six amino acid differences compared to the previously published mouse sequence were found. Moreover, the 3' non-coding end was completely different. Part of these findings were confirmed in three different mouse strains. The resulting mouse cDNA resembles the human APP more closely than originally reported.
De Strooper
B
B
Center for Human Genetics, University of Leuven, Belgium.
Van Leuven
F
F
Van den Berghe
H
H
D000595:Amino Acid Sequence; D016564:Amyloid beta-Protein Precursor / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D012689:Sequence Homology, Nucleic Acid
D016564:Amyloid beta-Protein Precursor