Effects of nifedipine pretreatment on subjective and cardiovascular responses to intravenous cocaine in humans.
The effects of oral nifedipine pretreatment on subjective and cardiovascular responses to intravenous cocaine infusions were studied in cocaine-using volunteers. Nifedipine, 10 mg or placebo, was administered 20-25 min before placebo, 20 mg, or 40 mg cocaine, using a repeated measures randomized double-blind design. The variables measured were self-reported subjective effects, general behavior rated by two observers, blood pressure and heart rate. Cocaine produced the expected dose-related effects on subjective and cardiovascular measures. Nifedipine pretreatment attenuated some subjective effects of cocaine. Nifedipine directly reduced blood pressure but did not antagonize the effects of cocaine on blood pressure. These findings suggest that dihydropyridine calcium channel modulators may be useful compounds in the clinical management of cocaine users.
Muntaner
C
C
National Institute on Drug Abuse Addiction Research Center, Baltimore, MD 21224.
Kumor
K M
KM
Nagoshi
C
C
Jaffe
J H
JH
D000328:Adult; D000339:Affect / Q000187:drug effects; D001007:Anxiety / Q000139:chemically induced / Q000523:psychology; D001794:Blood Pressure / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D003221:Confusion / Q000139:chemically induced / Q000523:psychology; D004311:Double-Blind Method; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation
D003042:Cocaine; D009543:Nifedipine