Acetonitrile serum concentrations and cyanide blood levels in a case of suicidal oral acetonitrile ingestion.
Acute acetonitrile toxicity is mainly dependent on the release of cyanide via hepatic metabolism. Although evaluated in animals, few data are available concerning the toxicokinetic parameters of acetonitrile and acetonitrile-liberated cyanide in human. This paper reports a case of suicidal oral acetonitrile ingestion of about 5 mL without severe symptoms of intoxication in a previously healthy adult male with a body weight of 60 kg. Acetonitrile serum concentrations as well as cyanide blood levels were determined over the whole hospitalization. The elimination half-lives calculated from these data were 32 h for acetonitrile and 15 h for cyanide. After sodium thiosulfate bolus application, the cyanide blood level rapidly decreased to 10% of the initial value, indicating that sodium thiosulfate sufficiently detoxifies acetonitrile-liberated cyanide. Since cyanide levels again increased to maximal values about 4.5 h after sodium thiosulfate application, continued thiosulfate therapy is required as predicted by the long elimination half-lives of acetonitrile and acetonitrile-liberated cyanide. Determination of cyanide and acetonitrile concentrations is recommended for the estimation of optimal individual sodium thiosulfate dosage.
Michaelis
H C
HC
Department of Pharmacology and Toxicology, University of Göttingen, Germany.
Clemens
C
C
Kijewski
H
H
Neurath
H
H
Eggert
A
A
D000097:Acetonitriles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D000284:Administration, Oral; D000328:Adult; D002849:Chromatography, Gas; D003486:Cyanides / Q000097:blood*; D006801:Humans; D008297:Male; D013406:Suicide, Attempted
D000097:Acetonitriles; D003486:Cyanides; C032159:acetonitrile