Chai-ling-tang (Japanese name: sairei-to) as an oral adjuvant.
Immunomodulating and anti-tumor activities of orally administered Chai-Ling-Tang (Japanese name: sairei-to, ST) were investigated. The oral administration of ST into mice augmented the antibody response to intraperitoneally administered 2, 4, 6-trinitrophenyl-haptenated sheep red blood cells (TNP-SRBC). Orally administered ST showed also an enhancing effect on the antibody response to TNP-SRBC administered by the oral route. In addition, orally administered ST markedly activated the peritoneal macrophages to enhanced phagocytic and lysosomal enzyme activities. A significant inhibition of tumor growth was observed in a syngeneic tumor-mouse system when ST was administered orally. These results suggest that ST has an efficiency as an oral adjuvant or an oral biological response modifier (BRM).
Egawa
Y
Y
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy, Japan.
Suzuki
I
I
Nagi
N
N
Yadomae
T
T
Kawakita
T
T
Kikuchi
S
S
Nomoto
K
K
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D007070:Immunoglobulin A / Q000096:biosynthesis; D007155:Immunologic Factors / Q000008:administration & dosage; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000276:immunology / Q000628:therapy
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D007070:Immunoglobulin A; D007155:Immunologic Factors