title: Hyperimmunoglobulinemia D following cancer chemotherapy.
abstract: Five classes of serum immunoglobulin levels were investigated in 107 children with malignant or benign tumors. Hyperimmunoglobulinemia D (hyper-IgD) was observed in 31 of 82 children who were in complete remission off chemotherapy with a median follow-up of 4.5 years after cessation of chemotherapy. On the other hand, hyper-IgD was not found among 12 children with malignant or benign tumors treated with chemotherapy and a low incidence of hyper-IgD was observed during chemotherapy (1 of 13 cases). The result indicates that hyper-IgD is not uncommon in children off chemotherapy, suggesting that dysregulation of IgD synthesis persists long after cessation of antineoplastic drugs.
authors.affiliation: Department of Pediatrics, Mie University School of Medicine, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Azuma
authors.forename: S
authors.initials: S
authors.lastname: Masuda
authors.forename: M
authors.initials: M
authors.lastname: Hanada
authors.forename: Y W
authors.initials: YW
authors.lastname: Zhou
authors.forename: S L
authors.initials: SL
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Komada
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000139:chemically induced*; D007072:Immunoglobulin D; D008297:Male; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D007072:Immunoglobulin D