Effect on sodium sulphate on the adsorption of chloroquine and mefloquine to activated charcoal.
The effect of an added saline cathartic (Sodium sulphate) on the in vitro adsorption of chloroquine and mefloquine by activated charcoal were determined. Chloroquine phosphate at 125, 250 and 500 micrograms/ml had 10.0, 23.0 and 38.4 percent adsorption to 50 mg charcoal. When the concentration of activated charcoal was increased from 50 to 200 mg, there was no significant difference in the amount of chloroquine adsorbed. The amount of mefloquine (400-1000 ng/ml) adsorbed ranged from 60.62 to 95.8 percent. The common saline purgatives sodium sulphate at 7.5 mg/ml increased the B-50 for chloroquine slightly from 376 to 444 mg whereas it has little or no effect on the adsorption of mefloquine to activated charcoal.
Orisakwe
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OE
Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
Akintonwa
A
A
D000327:Adsorption / Q000187:drug effects; D002606:Charcoal; D002738:Chloroquine / Q000737:chemistry*; D006801:Humans; D015767:Mefloquine / Q000737:chemistry*; D013431:Sulfates / Q000494:pharmacology*
D013431:Sulfates; C012036:sodium sulfate; D002606:Charcoal; D002738:Chloroquine; D015767:Mefloquine