Immunohistological characterization of lymph nodes in two cases of adult onset Still's disease.
Although lymphadenopathy occurs in 60% of patients with adult Still's disease, its histopathological pattern has only recently been described. We report on the immunohistological study of a lymph node biopsy and the clinical course of 2 patients with adult Still's disease. The lymph node histology was characterized by a diffuse paracortical expansion with a high content of immunoblasts and plump endothelium venules. Immunohistochemistry using the alkaline phosphatase, antialkaline phosphatase technique showed the mixed B and T cell nature both of proliferating cells and immunoblasts. When antiheavy and light chain reagents were applied, the B cell component became polytypic. Our report stresses the relevance of immunohistological investigation in the diagnostic approach to Still's disease in which histological findings, if taken alone, might be misleading.
Quaini
F
F
Rheumatic Disease Unit, Hospital of Parma, Italy.
Manganelli
P
P
Pileri
S
S
Magnani
G
G
Ferrari
C
C
Delsignore
R
R
Sabattini
E
E
Olivetti
G
G
D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis; D001402:B-Lymphocytes / Q000201:enzymology / Q000473:pathology; D001706:Biopsy; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000201:enzymology* / Q000473:pathology; D008297:Male; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D013601:T-Lymphocytes / Q000201:enzymology / Q000473:pathology
D000469:Alkaline Phosphatase