title: Human temporal bone findings in acquired hypothyroidism.
abstract: Histological studies of the auditory organ in patients with acquired hypothyroidism are scarce. Thus the aim of the present study was to examine the temporal bones and the brain in subjects with hypothyroidism. Four temporal bones and two brains from clinically and biochemically hypothyroid subjects were removed and evaluated by light microscopy determine to the morphological changes and deposition of neutral and acid glycosaminoglycans. An audiogram from one of the patients showed a sensorineural hearing loss, which could be ascribed to occupational noise exposure. The study revealed histological changes compatible with age and infectious disease. No accumulation of neutral or acid glycosaminoglycans could be demonstrated in the temporal bones, or in the brains.
authors.affiliation: Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Hald
authors.forename: C M
authors.initials: CM
authors.lastname: Milroy
authors.forename: K D
authors.initials: KD
authors.lastname: Jensen
authors.forename: A
authors.initials: A
authors.lastname: Parving
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D003238:Connective Tissue / Q000737:chemistry; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D007037:Hypothyroidism / Q000473:pathology*; D010525:Peripheral Nerves / Q000737:chemistry; D013701:Temporal Bone / Q000473:pathology*
chemical_list: D006025:Glycosaminoglycans