title: High dietary fat increases toxicity of diacetoxyscirpenol in chickens.
abstract: The influence of high dietary fat on the toxicity of diacetoxyscirpenol (DAS) was investigated in a 2 x 5 factorial arrangement of treatments (6 and 12% fat, and 0, 1, 2, 4, and 8 micrograms DAS/g diet). The 3-wk body weight was decreased (P less than .0001) by DAS, but fat had no significant (P less than .05) effect. There was a highly significant (P less than .0059) interaction manifested at the higher levels of DAS by a greater decrease in body weight in the high-fat diet than in the low-fat diet. Neither feed conversion nor percentage of fat in fecal material were affected significantly (P less than .05) by DAS. These data were consistent with the high-fat diet promoting lipid micellar absorption of DAS and with DAS, once absorbed, inhibiting protein synthesis at the ribosomal level, a well established mechanism of action for trichothecene toxins such as DAS.
authors.affiliation: Department of Animal Science, North Carolina A&T State University, Greensboro 27411.
authors.forename: A A
authors.initials: AA
authors.lastname: Ademoyero
authors.forename: P B
authors.initials: PB
authors.lastname: Hamilton
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000254:growth & development*; D004041:Dietary Fats / Q000008:administration & dosage*; D004435:Eating / Q000187:drug effects; D008297:Male; D015651:Mycotoxicosis / Q000662:veterinary*; D009183:Mycotoxins / Q000633:toxicity; D011201:Poultry Diseases / Q000139:chemically induced*; D014255:Trichothecenes / Q000633:toxicity*
chemical_list: D004041:Dietary Fats; D009183:Mycotoxins; D014255:Trichothecenes; C001809:diacetoxyscirpenol