Molecular dissection of the secretory pathway.
A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution.
Rothman
J E
JE
Program of Cellular Biochemistry and Biophysics, Rockefeller Research Laboratory, Sloan-Kettering Institute, New York, New York 10021.
Orci
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L
D000595:Amino Acid Sequence; D000818:Animals; D002468:Cell Physiological Phenomena; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006056:Golgi Apparatus / Q000502:physiology*; D007425:Intracellular Membranes / Q000502:physiology; D008561:Membrane Fusion; D008954:Models, Biological; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000502:physiology; D015398:Signal Transduction