Erosive arthritis in monoclonal gammopathy of uncertain significance: report of four cases.
We report 4 case histories in which an erosive arthritis was associated with the presence of a monoclonal gammopathy of uncertain significance. In all 4 cases, the appearance of paraprotein was noted either before or during the development of the arthritis. Two patients had a rather atypical oligoarthritis, while the others had a rheumatoid-like, symmetric polyarthritis. A synovial amyloid deposit was present in 2 patients, while mild mixed mononuclear infiltrates were the main pathologic finding in the others. In 2 patients, immunohistochemical investigation demonstrated deposits of immunoglobulin-derived material of the same isotype as the monoclonal component in the synovial tissue.
Vitali
C
C
Clinical Immunology Unit, University of Pisa, Italy.
Baglioni
P
P
Vivaldi
I
I
Cacialli
R
R
Tavoni
A
A
Bombardieri
S
S
D000368:Aged; D000682:Amyloid / Q000032:analysis / Q000378:metabolism; D001168:Arthritis / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000378:metabolism; D007146:Immunoglobulin lambda-Chains / Q000032:analysis / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D010266:Paraproteins / Q000378:metabolism; D000685:Serum Amyloid A Protein / Q000032:analysis / Q000378:metabolism; D013583:Synovial Membrane / Q000737:chemistry / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000032:analysis / Q000378:metabolism
D000682:Amyloid; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D010266:Paraproteins; D000685:Serum Amyloid A Protein; D001613:beta 2-Microglobulin