Spectrin breakdown products increase with age in telencephalon of mouse brain.
Calcium activated proteolysis of brain spectrin produces characteristic breakdown products (BDPs), the concentrations of which increase markedly in many instances of brain pathology. Results reported here indicate that levels of the BDPs rise with age (3-30 months) in the telencephalon but not in the hindbrain of Balb/c mice. These observations suggest that spectrin breakdown is a pathologic biochemical marker which increases with age in some but not all brain regions.
Bahr
B A
BA
Center for Neurobiology of Learning and Memory, University of California, Irvine 92717-3800.
Vanderklish
P W
PW
Ha
L T
LT
Tin
M T
MT
Lynch
G
G
D000375:Aging / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D001923:Brain Chemistry / Q000502:physiology; D002154:Calpain / Q000378:metabolism; D015151:Immunoblotting; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013049:Spectrin / Q000378:metabolism*; D013687:Telencephalon / Q000378:metabolism*
D015415:Biomarkers; D013049:Spectrin; D002154:Calpain