Protective effect of cyproheptadine in a gerbil model of cerebral ischemia.
The efficacy of Cyproheptadine, a serotonin antagonist, in preventing the cerebral ischemic damage was tested on experimental model of transient global cerebral ischemia in Mongolian Gerbil. The semi-quantitative histological evaluation of the severity of ischemic damage showed a protective effect of Cyproheptadine, mainly in the anterior cortical areas.
Caponnetto
C
C
Clinica Neurologica dell'Università di Genova.
Del Sette
M
M
Furlan
M
M
Gandolfo
C
C
Mancardi
G L
GL
Schenone
A
A
Loeb
C
C
D000818:Animals; D001921:Brain / Q000473:pathology; D003533:Cyproheptadine / Q000627:therapeutic use*; D005260:Female; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000517:prevention & control*; D012701:Serotonin / Q000502:physiology
D003533:Cyproheptadine; D012701:Serotonin