Close linkage of esterase-D to unipolar depression and alcoholism is ruled out in eight pedigrees.
Unipolar depression and alcoholism were tested for genetic linkage to esterase-D at 13q14.1. Tight linkage to esterase-D was ruled out for three phenotypes using three models of penetrance: (1) unipolar depression and alcoholism taken together as affected, (2) unipolar depression alone as affected with alcoholism considered unaffected and (3) alcoholism alone as affected with unipolar depression considered unaffected. This study does not support an earlier finding of possible linkage between the esterase-D locus at 13q14.1 and alcoholism.
Wesner
R B
RB
Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52242.
Tanna
V L
VL
Palmer
P J
PJ
Thompson
R J
RJ
Crowe
R R
RR
Winokur
G
G
D000293:Adolescent; D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002882:Chromosomes, Human, Pair 13; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype
D005819:Genetic Markers; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; C020118:ESD protein, human