[Antibacterial and bactericidal activities of tea extracts and catechins against methicillin resistant Staphylococcus aureus].
We examined tea extract, (-) epigallocatechin gallate (EGCg) and theaflavin digallate (TF3) for their antibacterial and bactericidal activities against methicillin resistant Staphylococcus aureus (MRSA) and food poisoning strains of S. aureus. Twenty percent tea extract (50 microliters), EGCg (63 micrograms) and TF3 (125 micrograms) added to one ml of culture medium each inhibited the growth of all strains of MRSA and food poisoning S. aureus tested. Tea extract showed also a bactericidal activity against MRSA even at the same concentration of as in ordinarily brewed tea. EGCg at a concentration of 250 micrograms/ml showed a bactericidal activity against MRSA but not against food poisoning S. aureus, but at 500 micrograms/ml reduced markedly the viable number within 48h. These results suggest that tea and catechin can be used as prophylactic agents against MRSA infection.
Toda
M
M
Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo.
Okubo
S
S
Hara
Y
Y
Shimamura
T
T
D044946:Biflavonoids; D002392:Catechin / Q000031:analogs & derivatives*; D005419:Flavonoids / Q000494:pharmacology*; D005517:Foodborne Diseases / Q000382:microbiology; D006801:Humans; D016106:Methicillin Resistance; D010936:Plant Extracts / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013662:Tea
D044946:Biflavonoids; D005419:Flavonoids; D010936:Plant Extracts; D013662:Tea; C056068:theaflavin; D002392:Catechin; C057580:gallocatechol