title: Eruptive epidermal cysts and multiple squamous cell carcinomas after therapy for cutaneous T-cell lymphoma.
abstract: Both topical nitrogen mustard and psoralen photochemotherapy may induce benign and malignant alterations in the skin. We describe the explosive appearance of multiple epidermal cysts and squamous cell carcinomas in a patient whose cutaneous T-cell lymphoma was treated sequentially with these two types of therapy. This is the first report of both processes in the same patient with cutaneous T-cell lymphoma. It strongly supports the concept of lesion induction, while raising the question of an additive or even synergistic effect of these types of therapy.
authors.affiliation: Department of Dermatology, Boston Veterans Administration Medical Center, MA 02130.
authors.forename: S P
authors.initials: SP
authors.lastname: Smith
authors.forename: N
authors.initials: N
authors.lastname: Konnikov
mesh_terms: D000279:Administration, Cutaneous; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004814:Epidermal Cyst / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy*; D008297:Male; D008466:Mechlorethamine / Q000009:adverse effects*; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D008466:Mechlorethamine