title: Chimerism as the etiology of a 46,XX/46,XY fertile true hermaphrodite.
abstract: OBJECTIVE
  To determine the conceptional events resulting in a 46,XX/46,XY true hermaphrodite and to report the first pregnancy in a 46,XX/46,XY true hermaphrodite with an ovotestis.
  
  
  METHODS
  Chromosome studies were performed on patient lymphocytes and fibroblasts. Red cell antigens, human leukocyte antigens, and presence of Y-chromosome deoxyribonucleic acid were analyzed. Findings were compared with parental and sibling blood group data.
  
  
  METHODS
  Genetics clinic and laboratories of a university hospital.
  
  
  RESULTS
  These studies demonstrated that our patient is a chimera, with dual maternal and paternal contributions. In addition, despite the presence of an ovotestis, she conceived and delivered a child.
  
  
  CONCLUSIONS
  The mechanism for chimerism in this case could be fertilization of (1) the secondary oocyte and first polar body; (2) the ovum and first polar body; (3) the ovum and second polar body; or (4) fusion of two embryos.
authors.affiliation: Department of Obstetrics and Gynecology, Chicago Lying-In Hospital, Illinois.
authors.forename: M S
authors.initials: MS
authors.lastname: Verp
authors.forename: H H
authors.initials: HH
authors.lastname: Harrison
authors.forename: C
authors.initials: C
authors.lastname: Ober
authors.forename: D
authors.initials: D
authors.lastname: Oliveri
authors.forename: A P
authors.initials: AP
authors.lastname: Amarose
authors.forename: V
authors.initials: V
authors.lastname: Lindgren
authors.forename: A
authors.initials: A
authors.lastname: Talerman
mesh_terms: D000328:Adult; D001483:Base Sequence; D002678:Chimera / Q000235:genetics*; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D012734:Disorders of Sex Development / Q000235:genetics*; D005260:Female; D005836:Genitalia, Female / Q000002:abnormalities; D006801:Humans; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes / Q000235:genetics; D010641:Phenotype; D011247:Pregnancy
chemical_list: D015345:Oligonucleotide Probes; D004247:DNA