Can terbutaline be used as a nebuliser instead of intravenous injection for inhibition of uterine activity?
Terbutaline, a betamimetic drug, is used as bolus of 0.25 mg intravenously to inhibit uterine activity when encountered with uterine hyperstimulation and associated fetal heart rate changes. The effect of terbutaline used as a nebuliser in 1- and 2-mg doses on uterine activity in labor was investigated. It did not show any significant inhibition of the uterine activity in spontaneous term labor. Although convenient and easy to administer especially in an emergency, 1 or 2 mg terbutaline used in the form of nebuliser did not give the desired effect like 0.25 mg of terbutaline given intravenously for inhibition of uterine activity in term labor.
Kurup
A
A
Department of Obstetrics and Gynaecology, National University of Singapore.
Arulkumaran
S
S
Tay
D
D
Ingemarsson
I
I
Ratnam
S S
SS
D000281:Administration, Intranasal; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000187:drug effects*; D009330:Nebulizers and Vaporizers; D011247:Pregnancy; D013726:Terbutaline / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D014590:Uterine Contraction / Q000187:drug effects*
D013726:Terbutaline