title: 2,4-D toxicosis.II: A pilot study of clinical pathologic and electroencephalographic effects and residues of 2,4-D in orally dosed dogs.
abstract: English pointer dogs dosed po with encapsulated 2,4-dichlorophenoxyacetic acid (2,4-D) at 1.3, 8.8, 43.7, 175 or 220 mg/kg body weight failed to exhibit abnormalities in hematologic, serum biochemical, urinalysis, or electrocardiographic parameters. At the 3 lowest doses, no changes were noted in electro-encephalograms (EEGs). In the dog given 175 mg/kg, at 24 h postdosing mild sedation was accompanied by excessive slowing in the EEG with loss of low voltage fast activity. In the dog given 220 mg/kg, nonspecific alterations in the EEG suggestive of irritation and mild seizure activity was detected 7 h, but the EEG returned to normal by 24 h. A maximum 2,4-D concentration in serum of 1075 ppm was detected 5 h after a po dose of 220 mg/kg. A maximum 2,4-D, concentration in urine of 1792 ppm was detected 2 h after a po dose of 175 mg/kg, while 25 h after that dose kidney issue contained 271 ppm.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana 61801.
authors.forename: E K
authors.initials: EK
authors.lastname: Arnold
authors.forename: V R
authors.initials: VR
authors.lastname: Beasley
authors.forename: A J
authors.initials: AJ
authors.lastname: Parker
authors.forename: J R
authors.initials: JR
authors.lastname: Stedelin
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000097:blood / Q000506:poisoning*; D000284:Administration, Oral; D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D004569:Electroencephalography; D004576:Electromyography; D010573:Pesticide Residues / Q000097:blood / Q000506:poisoning*; D010865:Pilot Projects; D011041:Poisoning / Q000503:physiopathology
chemical_list: D010573:Pesticide Residues; D015084:2,4-Dichlorophenoxyacetic Acid