T-cell tolerance to viruses.
T-cell tolerance to self antigens is maintained by events that occur within the thymus and in the periphery. Mechanisms that operate on immature T cells within the thymus are effective in induction of tolerance to viruses, but mechanisms of tolerizing mature T cells are likely to break down. This failure of peripheral mechanisms to induce T-cell tolerance to viruses has implications for autoimmunity and for treatment of chronic viral infections.
Ahmed
R
R
University of California Los Angeles School of Medicine.
D000818:Animals; D015551:Autoimmunity; D007108:Immune Tolerance; D007111:Immunity, Cellular; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*