title: Delivery dependent oxygen consumption in patients with septic shock: daily variations, relationship with outcome and the sick-euthyroid syndrome.
abstract: Delivery dependent oxygen consumption (DDOC) is observed in patients with sepsis and vital organ dysfunction, and has been related to outcome. Similarly the sick-euthyroid syndrome is associated with a high mortality. We examined the daily variations of DDOC and its relation to hormonal changes, particularly those of the thyroid. In 22 patients, 14 with septic shock and 8 post-operative controls, oxygen delivery was increased by increasing cardiac output with vasodilation by phentolamine, during a total of 207 days. DDOC varied markedly between consecutive days in individual patients with sepsis, in both survivors and non-survivors. DDOC was related to severity of illness, assessed by APACHE II score (r = 0.50, p = 0.017), and plasma levels of triiodothyronine (T3), r = -0.49, p = 0.011, and thyroxine (T4), r = -0.53, p = 0.012. No correlation was observed between DDOC and outcome, nor blood levels of lactate, epinephrine, norepinephrine, dopamine or cortisol. In conclusion, we observed a marked disturbance of systemic oxygen uptake autoregulation in patients with septic shock which varied during the clinical course and was related to the sick-euthyroid syndrome.
authors.affiliation: Department of Anesthesiology, University Hospital of Geneva, Switzerland.
authors.forename: M G
authors.initials: MG
authors.lastname: Palazzo
authors.forename: P M
authors.initials: PM
authors.lastname: Suter
mesh_terms: D000328:Adult; D000368:Aged; D005067:Euthyroid Sick Syndromes / Q000150:complications / Q000378:metabolism* / Q000401:mortality; D006439:Hemodynamics; D006785:Hospitals, University; D006801:Humans; D007362:Intensive Care Units; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008875:Middle Aged; D010101:Oxygen Consumption; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000150:complications / Q000378:metabolism* / Q000401:mortality; D015996:Survival Rate; D013557:Switzerland / Q000453:epidemiology; D013566:Sympathomimetics / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood; D016896:Treatment Outcome
chemical_list: D007773:Lactates; D013566:Sympathomimetics; D013963:Thyroid Hormones; D019344:Lactic Acid