title: [Antiphospholipid antibodies--antiphospholipid syndrome. Cause or consequence of thrombosis].
abstract: Antiphospholipid antibodies (APA) are heterogeneous immunoglobulines of G, M or A classes with specificity directed towards anionic phospholipids. The APA are associated with a wide variety of diseases. They have been found to represent risk factor for development of arterial and/or veinous thrombosis. The APA would perturbed the biological activities of anionic phospholipid surface in a manner that could decrease the natural anti-coagulant pathway in order to lead to thrombosis. In the latter hypothesis APA would appear as a secondary response to the exposure of phospholipid "self antigens" by activated or damaged blood vascular cells by known stimuli able to induce thrombosis. In these cases APA would therefore constitute a marker of risk of thrombosis. The question which remains to be solved is if APA possess their own pathogenic potential or if they appear as the result of an up-stream pathological event known to be favourable to the development of thrombosis or if both mechanism are involved.
authors.affiliation: Laboratoire d'Hémostase, Hôpital Saint-Louis, Paris, France.
authors.forename: M L
authors.initials: ML
authors.lastname: Scrobohaci
authors.forename: J M
authors.initials: JM
authors.lastname: Freyssinet
mesh_terms: D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D001777:Blood Coagulation / Q000502:physiology; D006801:Humans; D007070:Immunoglobulin A / Q000502:physiology; D007074:Immunoglobulin G / Q000502:physiology; D007075:Immunoglobulin M / Q000502:physiology; D010743:Phospholipids / Q000276:immunology; D013927:Thrombosis / Q000209:etiology* / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010743:Phospholipids
vernacular_title: Anticorps antiphospholipides--syndrome antiphospholipides. Cause ou conséquence de la thrombose.