[Participation of peptide hydra morphogen in the regulation of proliferation processes in different tissues of white rats].
The PMH influence on proliferation processes in some tissues of white rats was studied. PMH injections in doses 10.0 mkg/kg and 100.0 mkg/kg stimulated the processes of DNA--synthesis after 24 hours in corneal and tongue epithelium. The direct dose-dependent effect was revealed. PMH in dose 10.0 mkg/kg activated the proliferative processes in the stomach epithelium and thymus cortex. after 24 hours too. The given dose of PMH caused trustworthy decreasing of proliferative activity in thymus after 4 hours. The stimulation of DNA-synthesis and acceleration of mitosis were found after 5-times application on white rat's corneal with 100 nM PMH solution.
Khomichuk
A Iu
AIu
Timoshin
S S
SS
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D003315:Cornea / Q000166:cytology / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects; D009479:Neuropeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D013270:Stomach / Q000166:cytology / Q000187:drug effects; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D014059:Tongue / Q000166:cytology / Q000187:drug effects
D009479:Neuropeptides; C032522:head activator peptide; D004247:DNA; D011761:Pyrrolidonecarboxylic Acid
Uchastie peptidnogo morfogena gidry v reguliatsii protsessov proliferatsii razlichnykh tkaneĭ belykh krys.