title: Rationale for local toxicity of calcium chelators.
abstract: Calcium chelating agents, such as ethylenediaminetetraacetate are toxic to urothelium. Their capacity to form complexes with calcium ions, which is the basis for their chemolytical effectiveness, also determines their toxicity. A decrease of chemolytical effectiveness by prior saturation of the chelator with Ca2+ or by lowering the pH to levels unfavourable for calcium binding significantly diminishes tissue injury. Exchange of Mg2+ ions does not, however, diminish tissue damage. The clinical use of calcium ligands is therefore unsafe.
authors.affiliation: Department of Urology, State University of Ghent, Belgium.
authors.forename: W
authors.initials: W
authors.lastname: Oosterlinck
authors.forename: R
authors.initials: R
authors.lastname: Verbeeck
authors.forename: C
authors.initials: C
authors.lastname: Cuvelier
authors.forename: D
authors.initials: D
authors.lastname: Vergauwe
mesh_terms: D000818:Animals; D002118:Calcium; D002614:Chelating Agents / Q000633:toxicity*; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D004533:Egtazic Acid / Q000633:toxicity; D006863:Hydrogen-Ion Concentration; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects*
chemical_list: D002614:Chelating Agents; D004533:Egtazic Acid; D004492:Edetic Acid; C026060:N-(hydroxyethyl)ethylenediaminetriacetic acid; D002118:Calcium