[Glutathione levels and the activity of the enzymes of glutathione metabolism in erythrocytes of patients with acute cholecystitis].
It is shown that in acute cholecystitis patients versus chronic cholecystitis ones and donors, the total glutathione in blood is lower while the activity of glutathione metabolism enzymes in red blood cells inhibited. Enzymological findings correlate with clinical symptoms of intoxication. Surgery aggravates disturbed activity of the enzymes. Conventional conservative therapy is not effective in normalizing the enzymes activity either. A good therapeutic response can be achieved by a directed transport of antibiotics in autologous blood ghosts which promotes recovery of normal activity of glutathione metabolism enzymes, routine glutathione level, early stabilization of hepatocytic membranes beneficial for surgical patients.
Pomelov
V S
VS
Zhumalilov
Zh Sh
ZhSh
Korotkina
R N
RN
Karelin
A A
AA
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002764:Cholecystitis / Q000097:blood* / Q000188:drug therapy; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000097:blood* / Q000172:deficiency; D005979:Glutathione Peroxidase / Q000097:blood* / Q000172:deficiency; D005980:Glutathione Reductase / Q000097:blood* / Q000172:deficiency; D005982:Glutathione Transferase / Q000097:blood* / Q000172:deficiency; D006638:Histidine Ammonia-Lyase / Q000097:blood* / Q000172:deficiency; D006801:Humans; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood* / Q000172:deficiency
D000900:Anti-Bacterial Agents; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D014568:Urokinase-Type Plasminogen Activator; D006638:Histidine Ammonia-Lyase; D005978:Glutathione
Dinamika urovnia glutationa i aktivnosti fermentov obmena glutationa v éritrotsitakh bol'nykh ostrym kholetsistitom.