title: Genes necessary for directed axonal elongation or fasciculation in C. elegans.
abstract: The outgrowth of single axons through different cellular environments requires distinct sets of genes in the nematode C. elegans. Three genes are required for the pioneering circumferential outgrowth of identified motor neuron axons between the lateral hypodermal cell membrane and the basal lamina. Three other genes are required for the longitudinal outgrowth of these axons along preexisting axon bundles as well as for the fasciculation of axons within these neuron bundles. Five additional genes are required for circumferential outgrowth, longitudinal outgrowth, and fasciculation; mutations in three of these genes disrupt axon ultrastructure, suggesting that they function in axon formation rather than in axon guidance.
authors.affiliation: Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
authors.forename: S L
authors.initials: SL
authors.lastname: McIntire
authors.forename: G
authors.initials: G
authors.lastname: Garriga
authors.forename: J
authors.initials: J
authors.lastname: White
authors.forename: D
authors.initials: D
authors.lastname: Jacobson
authors.forename: H R
authors.initials: HR
authors.lastname: Horvitz
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure*; D002107:Caenorhabditis / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D005207:Fasciculation / Q000235:genetics / Q000503:physiopathology*; D005455:Fluorescent Antibody Technique; D005796:Genes / Q000235:genetics / Q000502:physiology*; D006128:Growth / Q000502:physiology; D008854:Microscopy, Electron; D009046:Motor Neurons / Q000502:physiology / Q000648:ultrastructure; D009154:Mutation / Q000235:genetics; D009420:Nervous System / Q000648:ultrastructure; D009424:Nervous System Physiological Phenomena