title: Arthritis in rhesus monkeys experimentally infected with simian immunodeficiency virus (SIV/DELTA).
abstract: The joint tissues from 36 rhesus (age 2-5 years) infected with SIV/Delta were graded into four groups and then correlated with the following systemic immunologic parameters: numbers of CD4+, CD4+ plus CD29+, and CD20+ cells and SIV/Delta antigenemia. Grade I (n = 16) consisted of normal synovial membrane; grade II (n = 8) consisted of synovial hyperplasia; grade III (n = 8) consisted of a mononuclear cell infiltrate, and grade IV (n = 4) consisted of synovial membrane infiltration of syncytial cell and mononuclear type cells. Synovial membranes from 20 uninfected age-matched rhesus were compared with infected animals and were graded 1. Immunostaining of the tissue phase lymphocytes and viral antigen was performed using monoclonal antibodies commercially available and a monoclonal antibody produced against a core protein of the SIV/Delta agent. SIV/Delta infection resulted in a reduction in cells doubly stained for CD4+ and CD29+ and a relative increase in CD8+ stained cells. A significant (ANOVA) difference was not observed in CD4+, CD4+ plus CD29+, CD8+, or CD20+ among the various grades of arthritis. Viral antigen was demonstrated in syncytial cells of the grade IV reaction. This finding suggests that the SIV/Delta arthritis is a primary viral reaction.
authors.affiliation: Delta Regional Primate Research Center, Tulane University, Covington, Louisiana.
authors.forename: E D
authors.initials: ED
authors.lastname: Roberts
authors.forename: L N
authors.initials: LN
authors.lastname: Martin
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001170:Arthritis, Infectious / Q000209:etiology*; D005260:Female; D016131:Lymphocyte Subsets / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology
chemical_list: D000956:Antigens, Viral