Dihydropyridine-induced release of catecholamines in cardiac tissue.
The symmetrically substituted dihydropyridine-dicarboxylate 3 exerts only weak calcium antagonistic activity on smooth muscles compared with the standard nifedipine. On electrically stimulated, left guinea pig-atria and particularly on electrically stimulated papillary muscles marked positive inotropic effects are registered. They can be attributed to release of catecholamines from intracellular stores.
Rose
U
U
Institut für Pharmazie, Johannes-Gutenberg-Universität Mainz.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism*; D004095:Dihydropyridines / Q000494:pharmacology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*
D002395:Catecholamines; D004095:Dihydropyridines; C038806:1,4-dihydropyridine