Beta glucuronidase and hyperbilirubinaemia in breast fed infants of diabetic mothers.
A prospective study was performed comparing bilirubin concentrations in 10 breast fed term infants of diabetic mothers (IDM) to those of 10 breast fed normal term infants. The beta-glucuronidase concentrations in serum and breast milk were assayed in the respective mothers. Significantly higher bilirubin concentrations were noted in the IDM group. Serum and breast milk beta-glucuronidase concentrations were significantly higher in diabetic mothers as compared with those of non-diabetic mothers. We suggest that the high concentration of beta-glucuronidase in breast milk of diabetic mothers is an additional important cause leading to hyperbilirubinaemia in their breast fed infants.
Sirota
L
L
Neonatology Unit, Hasharon Hospital, Golda Medical Centre, Petah-Tiqva, Israel.
Ferrera
M
M
Lerer
N
N
Dulitzky
F
F
D001663:Bilirubin / Q000097:blood*; D001942:Breast Feeding; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005966:Glucuronidase / Q000097:blood*; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology; D007223:Infant; D008895:Milk, Human / Q000201:enzymology*; D011446:Prospective Studies
D005966:Glucuronidase; D001663:Bilirubin