Basic studies of local adsorption in burn treatment.
The model of a full-thickness thermal burn in rats was used to demonstrate that the application of adsorptive dressings made of a fibrous activated carbon material (ACFM) after early excision of a burn crust exerts a considerable influence on the development of both local and general symptoms of burn disease. Three days after the excision a water content in underlying tissues falls from 84.81 +/- 0.62% to 54.47 +/- 4.2%, the wound surface area decreases by 10%, while this surface area under gauze bandages increases by 6.3%. The local adsorption results in lower activity of proteolytic serum enzymes and toxicity of blood serum in burned animals as well as in the positive dynamics of changes in functional activity of the immune system. By the 14th day the T-cell activity in animals with adsorptive carbon dressings was by 3.2 times higher than that in the animals with gauze bandages. The level of B-cell response if ACFM is applied exceeds normal values to a great extent, starting from the first days after the excision of a burn crust.
Sakhno
L A
LA
Kavetsky Institute for Oncology Problems, Academy of Sciences, Ukrainian SSR, Kiev, USSR.
Nikolaev
V G
VG
Lozinskaya
I A
IA
Yudin
V M
VM
Vovyanko
S I
SI
D000818:Animals; D001458:Bandages; D001834:Body Water / Q000378:metabolism; D002056:Burns / Q000628:therapy*; D002244:Carbon; D051381:Rats; D011919:Rats, Inbred Strains; D016060:Sorption Detoxification / Q000379:methods*; D014945:Wound Healing
D002244:Carbon