title: Primary malignant lymphoma of the central nervous system. Case report.
abstract: We report a case of primary malignant lymphoma of the central nervous system found in a 69-year old woman suffering from Parkinson's disease and hypertension. The CAT scan revealed an ill defined lesion in the left frontal lobe which at surgery appeared as a brownish-black friable neoformation. The histologic exam revealed a proliferation of voluminous round lymphoid cells with 2 or 3 nucleoli often apposed to the nuclear membrane. At the immunohistochemical investigation they were positive for LC and L26 monoclonal antibodies. Malignant centroblastic B-cell lymphoma was diagnosed. All post-surgery investigations excluded the presence of neoplasms in other sites.
authors.affiliation: Institute of Pathological Anatomy and Histology, First Chair, Perugia University.
authors.forename: E
authors.initials: E
authors.lastname: Bucciarelli
authors.forename: A
authors.initials: A
authors.lastname: Cavaliere
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D005625:Frontal Lobe; D006801:Humans; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D010300:Parkinson Disease / Q000150:complications
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins