[Copper metabolism in scleral tissue and possibilities of its correction in myopia].
Copper measurements in scleral tissue of 14 cadaveric emmetropic eyes and in 10 eyes with myopia of various degrees have shown a significant reduction of these levels in the equatorial and posterior segments of myopic sclera and abnormal distribution of copper in the tissue, this indicating disordered metabolism of this trace element. A method for drug correction of the detected disorder has been experimentally tried, consisting in administration under the Tenon's capsule of a copper coordination compound on a foam composition base, used for sclera-fortifying injections in progressive myopia. This resulted in elevation of scleral copper concentration, activization of collagen biosynthesis processes, and improvement of scleral tissue elasticity.
Avetisov
E S
ES
Vinetskaia
M I
MI
Iomdina
E N
EN
Makhmudova
F R
FR
Boltaeva
Z K
ZK
Tarutta
E P
EP
D000328:Adult; D002102:Cadaver; D003094:Collagen / Q000096:biosynthesis; D003300:Copper / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009216:Myopia / Q000188:drug therapy / Q000378:metabolism*; D012590:Sclera / Q000378:metabolism*
D003300:Copper; D003094:Collagen
Obmen medi v skleral'noĭ tkani i vozmozhnosti ego korrektsii pri myopii.