title: Ultrastructure of neurofibrillary tangles in Alzheimer's disease by means of tilt-stage electron microscopy.
abstract: Neurofibrillary tangles (NFT) in the brains of patients with Alzheimer's disease were examined by means of tilt-stage electron microscopy. Observing a longitudinal direction, constricted parts of the NFT did not move in an axial direction. In a transverse section, a fibril of the NFT consisted of globular subunits having a hollow structure in the center and did not appear as paired filaments. From these findings, it was considered that a fibril of NFT consists of twisted protofilaments made up of globular subunits and does not consist of paired helical filaments.
authors.affiliation: Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Katsuragi
authors.forename: T
authors.initials: T
authors.lastname: Miyakawa
authors.forename: K
authors.initials: K
authors.lastname: Ouchi
authors.forename: R
authors.initials: R
authors.lastname: Kuramoto
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000648:ultrastructure*