[Regeneration of the ciliary beat of human ciliated cells].
The influence of an isotonic, alkaline saline solution (diluted "Emser Sole" or brine from the spa of Bad Ems) on the ciliary beat of isolated cultured human ciliated cells of the upper respiratory tract was investigated. The ciliary beat was observed via an inverted phase contrast microscope (Zeiss Axiomat IDPC) and measured microphotometrically under physiological conditions and after the damaging influence of 1% propanal solution. Under physiological conditions the saline solution had a positive, although statistically not significant influence on the frequency of the ciliary beat. After damage of the cultivated cells by 1% propanal solution, the saline solution had a significant better influence on the regeneration of the cultured cells than a physiological sodium chloride solution. It is concluded that diluted brine from Bad Ems has a positive effect on the ciliary beat of the respiratory epithelium and accelerates its regeneration after damage by viral and bacterial infections, surgery or inhaled noxae.
Wolf
G
G
Universitäts-HNO-Klinik, Karl-Franzens-Universität Graz.
Koidl
B
B
Pelzmann
B
B
D000447:Aldehydes / Q000494:pharmacology; D002478:Cells, Cultured; D002923:Cilia / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007552:Isotonic Solutions; D008858:Microscopy, Phase-Contrast; D009068:Movement; D012038:Regeneration / Q000187:drug effects*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology*
D000447:Aldehydes; D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; C005556:propionaldehyde
Zur Regeneration des Zilienschlages humaner Flimmerzellen.