Mitochondrial protein import.
A dynamic picture of the mitochondrial protein import pathway is emerging, with conformational alteration a critical feature both preceding and following membrane translocation. The mediators of these steps of conformational alteration, as well as steps of recognition, translocation, and proteolytic cleavage, appear to be proteins. Using powerful tools of genetics and biochemistry, in years to come it should be possible to determine the precise molecular function of these proteins in mediating these novel reactions.
Horwich
A L
AL
Department of Human Genetics, Yale University, School of Medicine, New Haven, CT 06510-8005.
Cheng
M
M
West
A
A
Pollock
R A
RA
D000818:Animals; D001693:Biological Transport, Active; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D013367:Submitochondrial Particles / Q000378:metabolism
D021382:Protein Sorting Signals; D011506:Proteins