GH response to GH-releasing factor in dementia and its relation with TSH response to TSH-releasing factor.
We have studied the GH response to GH-releasing factor (GRF) and the TSH response to TSH-releasing factor (TRH) in two groups or patients with dementia. A group of 28 patients with Alzheimer's disease (AD) and another group of 28 patients with dementia of vascular origin (VD). The GH response to GRF exhibited no difference between AD and VD patients (12.2 +/- 10.85 micrograms/L vs. 9.96 +/- 9.9) and there was no correlation with GH response to GRF and sex, stage of the disease and cerebral atrophy. The number of cases with exaggerated, normal or without response were similar in AD or VD patients. The TSH response to TRH exhibited no difference between AD and VD patients (9.18 +/- 4.93 mU/ml vs. 10.35 +/- 8.81). There was no correlation with TSH response to TRH and sex, stage of the disease, cerebral atrophy and response of GH to GRF. The number of cases with exaggerated, normal or without response was similar in AD or VD patients.
Gómez Sáez
J M
JM
Endocrinology Service, Hospital de Bellvitge, Barcelona, Spain.
Aguilar Barberá
M
M
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D003704:Dementia / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D015140:Dementia, Vascular / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D008297:Male; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone