title: Biochemical changes in knee joint articular cartilage after cemented prosthetic hip hemiarthroplasty in dogs.
abstract: Biochemical changes in the distal femoral articular cartilage (knee joint) after cemented prosthetic replacement of the femoral head were determined. Femurs from dogs (n = 10) that had undergone cobalt-chromium prosthetic hip hemiarthroplasty (6-8 months postoperatively) were analyzed for articular cartilage lipids in the distal femur. The quantity of phosphatidylserine increased from 0.59 +/- 0.14 mg (uninvolved) to 1.52 +/- 0.23 mg (hemiarthroplasty) lipid phosphorus/100 g tissue, and the quantity of arachidonic acid in the articular cartilage increased from 0.23 +/- 0.07 mg (uninvolved) to 2.07 +/- 0.29 mg/100 g tissue (hemiarthroplasty). Likewise, hydroxyproline content was higher in the recipient femurs (77.4 +/- 1.58 micrograms/mg cartilage) versus uninvolved femurs (71.8 +/- 1.03 micrograms/mg cartilage); the activity of acid phosphatase was greater in the recipient distal femoral cartilage as compared with the uninvolved femur, 0.07 +/- 0.01 and 0.06 +/- 0.02 mol hydrolyzed per kilogram per hour, respectively, and the hexosamine content was lower in the recipient femur knee cartilage versus knee cartilage from uninvolved femurs, 54.5 +/- 1.51 and 63.1 +/- 1.37 micrograms/mg cartilage, respectively. These biochemical changes may suggest degeneration of the knee joint articular cartilage after cemented hip hemiarthroplasty.
authors.affiliation: Department of Orthopaedics, University of Illinois College of Medicine, Chicago 60680.
authors.forename: F J
authors.initials: FJ
authors.lastname: Papatheofanis
authors.forename: R
authors.initials: R
authors.lastname: Barmada
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D016718:Arachidonic Acid / Q000032:analysis; D001843:Bone Cements; D002358:Cartilage, Articular / Q000737:chemistry*; D004285:Dogs; D006595:Hexosamines / Q000032:analysis; D006622:Hip Prosthesis; D006909:Hydroxyproline / Q000032:analysis; D007719:Knee Joint; D008768:Methylmethacrylates; D010712:Phosphatidic Acids / Q000032:analysis*
chemical_list: D001843:Bone Cements; D006595:Hexosamines; D008768:Methylmethacrylates; D010712:Phosphatidic Acids; D016718:Arachidonic Acid; D000135:Acid Phosphatase; D006909:Hydroxyproline