Hepato-splenic distribution of 99Tcm-phytate and hepato-enteric distribution of 99Tcm-DISIDA in mice with carbon tetrachloride-induced acute liver damage.
The hepato-enteric distribution of 99Tcm-labelled DISIDA and the hepato-splenic distribution of 99Tcm-labelled phytate were studied in controls and in mice with carbon tetrachloride-induced acute liver damage. The test group animals showed a diminished excretion of DISIDA to intestine with retention of this tracer in the liver and an increased splenic uptake of phytate. No changes in the hepatic uptake of phytate were found. The joint evaluation of both tracers in the study of diffuse liver disease is discussed.
Lobo-Sotomayor
G
G
Unidade de Medicina Nuclear, Facultad de Medicina, Universidad de Chile, Hospital San Jan de Dios.
Mena
P
P
Wolff
C
C
Náquira
N
N
Blanco
G
G
Armas-Merino
R
R
Donoso
G
G
Sabarots
C
C
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury; D007098:Imino Acids / Q000493:pharmacokinetics*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008107:Liver Diseases / Q000378:metabolism; D051379:Mice; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D010833:Phytic Acid / Q000493:pharmacokinetics*; D013154:Spleen / Q000187:drug effects / Q000378:metabolism*; D019785:Technetium Tc 99m Disofenin
D007098:Imino Acids; D015609:Organotechnetium Compounds; C026177:technetium phytate; D010833:Phytic Acid; D019785:Technetium Tc 99m Disofenin