Effects of gamma-interferon on major histocompatibility complex antigen expression and lymphocytic infiltration in the 9L gliosarcoma brain tumor model: implications for strategies of immunotherapy.
Effects of gamma-interferon (IFN-gamma) on immune parameters in the 9L gliosarcoma model were examined. IFN-gamma increased class I major histocompatibility complex (MHC) expression in 9L cells in vitro. In vivo, intratumor injections of IFN-gamma led to increased numbers of inflammatory cells within the tumor and class II+ mononuclear phagocytes at its periphery, and increased MHC class I or II expression by endothelial and ependymal cells. Class I expression in 9L cells themselves was not increased. This suggests that there may be inhibition of class I induction in vivo for certain cell types, for which immunotherapies based on non-MHC restricted mechanisms may be more effective.
Wen
P Y
PY
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Lampson
M A
MA
Lampson
L A
LA
D000818:Animals; D001932:Brain Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D002465:Cell Movement / Q000187:drug effects; D005910:Glioma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006649:Histocompatibility Antigens / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007267:Injections; D007371:Interferon-gamma / Q000008:administration & dosage / Q000627:therapeutic use*; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012878:Skin Neoplasms / Q000628:therapy; D014407:Tumor Cells, Cultured
D006649:Histocompatibility Antigens; D007371:Interferon-gamma