title: How to assess fetal metabolic acidosis from cord samples.
abstract: The degree of metabolic acidosis at birth has been calculated in cord artery and vein samples from 21 term fetuses with cord artery pH less than 7.20. The aim of the study was to compare base deficit values calculated from either Siggaard-Andersen alignment nomogram (BD blood) or the Acid-Base chart (BD extra cellular fluid, BDecf). BDblood was found to be consistently higher in the cord artery as compared with BDecf, 13.2 +/- 3.5 and 9.9 +/- 2.9 mmol/l (Mean +/- SD), respectively. A significant correlation was found between cord artery PCO2 and BDblood whereas BDecf appeared unaffected by PCO2. In cases with cord entanglement BDecf a-v differences were increased to 3.4 +/- 2.3 mmol/l as compared with the small a-v difference noted in acidotic cases without cord entanglement, 1.1 +/- 1.25 mmol/l. It is speculated that with acutely emerging, intermittent asphyxia due to cord compression, a cord artery and vein difference in metabolic acidosis may exist and where the vein captures the basal level and the artery the acute changes. It is concluded that BDecf in both cord artery and vein add valuable information on the mechanisms behind metabolic acidosis.
authors.affiliation: Department of Physiology and Paediatrics I, Gothenburg University, Sweden.
authors.forename: K G
authors.initials: KG
authors.lastname: Rosén
authors.forename: K W
authors.initials: KW
authors.lastname: Murphy
mesh_terms: D000140:Acidosis, Lactic / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D014469:Umbilical Arteries; D014471:Umbilical Veins
chemical_list: D002245:Carbon Dioxide