title: Paranoid and aggressive behavior in two obsessive-compulsive adolescents treated with clomipramine.
abstract: Obsessive-compulsive disorder is increasingly recognized in patients of different age groups. Serotonergic agents, such as clomipramine, have been recently found to be useful in the management of this condition. However, unexpected side effects, such as dysphoria, aggressiveness, and paranoid ideation, may occur with therapeutic doses of this compound, as evidenced in the cases of two male adolescents presented here. Possible pathogenetic factors, involving serotonin and serotonin-receptor abnormalities are discussed. Management of these side effects is based on adequate dose reduction and monitorization.
authors.affiliation: Department of Psychiatry, University of Alabama Birmingham.
authors.forename: R D
authors.initials: RD
authors.lastname: Alarcon
authors.forename: B R
authors.initials: BR
authors.lastname: Johnson
authors.forename: J P
authors.initials: JP
authors.lastname: Lucas
mesh_terms: D000293:Adolescent; D000374:Aggression / Q000187:drug effects* / Q000523:psychology; D002220:Carbamazepine / Q000627:therapeutic use; D002648:Child; D002997:Clomipramine / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D010259:Paranoid Disorders / Q000139:chemically induced* / Q000523:psychology
chemical_list: D005473:Fluoxetine; D002220:Carbamazepine; D002997:Clomipramine