title: Down-regulation of hepatic lipase gene expression and activity by fenofibrate.
abstract: The influence of the hypolipidemic drug, fenofibrate, on hepatic lipase (HL) gene expression and activity was investigated in the rat. Fenofibrate treatment provoked a dose-dependent decrease in HL mRNA levels. At a dose of 0.5% (w/w), HL mRNA levels were reduced to nearly 50% the levels in untreated controls. This decrease was parallelled by a comparable reduction in liver HL activity. The decrease in HL mRNA levels was already observed after 1 day of fenofibrate treatment. Whole liver perfusion experiments showed that the heparin-releasable HL activity in fenofibrate-treated livers dropped to 10% the activity in control livers. In conclusion, treatment with fenofibrate decreases HL gene expression, leading to a lowered activity of endothelium bound HL in fenofibrate-treated livers.
authors.affiliation: Department of Developmental Biology, Gasthuisberg, Katholieke Universiteit Leuven, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Staels
authors.forename: J
authors.initials: J
authors.lastname: Peinado-Onsurbe
authors.forename: J
authors.initials: J
authors.lastname: Auwerx
mesh_terms: D000818:Animals; D015536:Down-Regulation / Q000187:drug effects*; D011345:Fenofibrate / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D008049:Lipase / Q000096:biosynthesis / Q000235:genetics*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008049:Lipase; D011345:Fenofibrate