title: Ofloxacin penetration into tuberculous pleural effusion.
abstract: After 3 days of treatment with ofloxacin (300 mg given orally once daily), the drug levels in serum and pleural fluid 2 and 4 h after drug administration in patients with tuberculous pleural effusion were assessed by a rapid high-performance liquid chromatography assay. The levels in serum (mean +/- standard error of the mean [SEM]) were 4.70 +/- 0.14 and 4.63 +/- 0.09 mg/liter 2 and 4 h after administration, respectively, and the levels in pleural fluid (mean +/- SEM) were 3.82 +/- 0.09 and 4.21 +/- 0.08  mg/liter, respectively. The pleural fluid-to-serum ofloxacin ratio at 2 h was 0.82 +/- 0.02 (mean +/- SEM), and the ratio at 4 h was 0.92 +/- 0.02 (mean +/- SEM). This study demonstrated very good penetration of ofloxacin into pleural fluid in tuberculous pleuritis.
authors.affiliation: Tuberculosis and Chest Unit, Grantham Hospital, Aberdeen, Hong Kong.
authors.forename: W W
authors.initials: WW
authors.lastname: Yew
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: C Y
authors.initials: CY
authors.lastname: Chan
authors.forename: S W
authors.initials: SW
authors.lastname: Cheung
authors.forename: P C
authors.initials: PC
authors.lastname: Wong
authors.forename: S Y
authors.initials: SY
authors.lastname: Kwan
mesh_terms: D000328:Adult; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis; D015242:Ofloxacin / Q000493:pharmacokinetics*; D010996:Pleural Effusion / Q000378:metabolism*; D014376:Tuberculosis / Q000378:metabolism* / Q000382:microbiology
chemical_list: D015242:Ofloxacin