title: Auditory evoked potentials in Gilles de la Tourette syndrome.
abstract: Gilles de la Tourette syndrome (TS) has been increasingly studied neurophysiologically as well as clinically. Obsessive-compulsive disorder (OCD) and attention deficit disorder (ADD) have been recognized to be part of the continuum of TS. We recorded brainstem auditory evoked potentials (BAEPs) and long-latency auditory event-related potentials (ERPs) in 20 patients with TS, 10 of whom had ADD and 6 OCD. TS patients with and without OCD and ADD did not differ in BAEP latencies, and no differences were found from normal controls. AEP latencies did not differ between TS patients and controls. TS patients with ADD had longer N100 and N200 latencies than TS patients without ADD, and TS patients with OCD had shorter N200 and P300 latencies. These findings suggest that TS is neurophysiologically heterogenous, and that TS patients with OCD or ADD may differ from those without.
authors.affiliation: Department of Neurology, Ohio State University Hospitals, Columbus.
authors.forename: M E
authors.initials: ME
authors.lastname: Drake
authors.forename: S A
authors.initials: SA
authors.lastname: Hietter
authors.forename: H
authors.initials: H
authors.lastname: Padamadan
authors.forename: J E
authors.initials: JE
authors.lastname: Bogner
authors.forename: J M
authors.initials: JM
authors.lastname: Andrews
authors.forename: S
authors.initials: S
authors.lastname: Weate
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications; D002648:Child; D005072:Evoked Potentials, Auditory; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications; D005879:Tourette Syndrome / Q000150:complications / Q000503:physiopathology*