Effect of nerve growth factor on lesioned PC12 cells.
The protecting effect of nerve growth factor (NGF) from hydrogen peroxide was studied on PC12 cells conditioned at 1 mM hydrogen peroxide with NGF and without NGF in comparison with cells treated with neither hydrogen peroxide nor NGF. NGF treatment of PC12 cells increased significantly the activity of catalase representing induction of free radical detoxifying mechanisms. The protection effect of NGF was reflected also on enhanced activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the cells.
Pechán
P
P
Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Czechoslovakia.
Cízková
D
D
Murgácová
M
M
Malatová
Z
Z
D000110:Acetylcholinesterase / Q000378:metabolism; D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004790:Enzyme Induction / Q000187:drug effects; D005609:Free Radicals; D006861:Hydrogen Peroxide / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000378:metabolism; D009414:Nerve Growth Factors / Q000494:pharmacology*; D010673:Pheochromocytoma / Q000473:pathology*; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology
D005609:Free Radicals; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors; D006861:Hydrogen Peroxide; D002374:Catalase; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase