Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects.
Ten healthy male subjects were administered i.v. meta-chlorophenylpiperazine (MCPP) (0.1 mg/kg) after oral ritanserin (5-10 mg), a putative 5HT1c/5HT2 (serotonin) antagonist, or placebo. Behavioral responses, cardiovascular effects, and neuroendocrine responses (cortisol, growth hormone, and prolactin) were measured serially for 4 hours after MCPP infusion. Premedication with ritanserin attenuated the MCPP-induced increases in self-rated anxiety and prolactin, and completely antagonized MCPP cortisol elevations. In contrast, ritanserin did not significantly alter growth hormone response to MCPP. These findings suggest a role for 5-HT1c/5-HT2 receptors in the endocrine and behavioral responses to the mixed serotonin agonist MCPP in humans.
Seibyl
J P
JP
Neuropsychiatric Studies Unit, West Haven VA Medical Center, CT 06516.
Krystal
J H
JH
Price
L H
LH
Woods
S W
SW
D'Amico
C
C
Heninger
G R
GR
Charney
D S
DS
D000328:Adult; D001007:Anxiety / Q000378:metabolism; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D013006:Growth Hormone / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D006854:Hydrocortisone / Q000302:isolation & purification / Q000378:metabolism; D008297:Male; D010555:Personality Inventory; D010879:Piperazines / Q000008:administration & dosage*; D010919:Placebos; D011388:Prolactin / Q000187:drug effects / Q000302:isolation & purification; D011985:Receptors, Serotonin / Q000187:drug effects*; D016713:Ritanserin / Q000008:administration & dosage*
D010879:Piperazines; D010919:Placebos; D011985:Receptors, Serotonin; D016713:Ritanserin; D011388:Prolactin; D013006:Growth Hormone; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone