Cancer of the cervix in women under 40 years of age, a regional survey, 1975-1984.
OBJECTIVE
To review the method and results of treatment of carcinoma of the cervix in women less than 40 years old.


METHODS
Retrospective review of all available case records.


METHODS
Yorkshire Regional Health Authority.


METHODS
428 women less than 40 years old treated for stage IB-IV carcinoma of the cervix between 1975 and 1984 inclusive.


METHODS
Overall survival by stage, effect of age, identifiable factors of prognostic significance, survival, grade 3 morbidity and pattern of recurrence in relation to treatment.


RESULTS
The 5-year actuarial percentage survival by stage was 78.4 (IB), 54.4 (II), 18.4 (III) and 0 (IV). Identifiable factors of prognostic importance were stage, nodal metastases (P less than 0.001) and tumour grade (P less than 0.01).


CONCLUSIONS
Primary surgical treatment for young women with early disease allows ovarian conservation and the avoidance of radiotherapy in 80% of them. Such treatment results in less local recurrence, particularly evident in patients with moderate or poorly differentiated tumours and a lower incidence of serious morbidity.
Peel
K R
KR
Department of Gynaecology, General Infirmary, Leeds.
Khoury
G G
GG
Joslin
C A
CA
O'Donovan
P J
PJ
Mgaya
H
H
Keates
G
G
Head
C
C
Thorogood
D J
DJ
D000328:Adult; D000367:Age Factors; D002584:Cervix Uteri / Q000473:pathology; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D009017:Morbidity; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000473:pathology / Q000628:therapy