title: In vivo measurement of cerebral oxygen consumption and blood flow using 17O magnetic resonance imaging.
abstract: We used 17O NMR imaging techniques to measure the H2(17)O concentration in a 0.8-ml voxel in the cat brain following injection of an arterial bolus of enriched H2(17)O and during inhalation of enriched 17O2. We also measured the H2(17)O concentration in arterial blood during 17O2 inhalation. The data from the first measurement were used to calculate the blood flow in the voxel. The data from all three measurements were combined to calculate the oxygen consumption in the voxel. The values of cerebral blood flow and oxygen consumption calculated with 17O NMR techniques agree reasonably well with values calculated for a similar region of the cat brain using autoradiographic techniques.
authors.affiliation: In Vivo NMR Research Center, National Institutes of Health, Bethesda, Maryland 20892.
authors.forename: J
authors.initials: J
authors.lastname: Pekar
authors.forename: L
authors.initials: L
authors.lastname: Ligeti
authors.forename: Z
authors.initials: Z
authors.lastname: Ruttner
authors.forename: R C
authors.initials: RC
authors.lastname: Lyon
authors.forename: T M
authors.initials: TM
authors.lastname: Sinnwell
authors.forename: P
authors.initials: P
authors.lastname: van Gelderen
authors.forename: D
authors.initials: D
authors.lastname: Fiat
authors.forename: C T
authors.initials: CT
authors.lastname: Moonen
authors.forename: A C
authors.initials: AC
authors.lastname: McLaughlin
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002415:Cats; D002560:Cerebrovascular Circulation; D005069:Evaluation Studies as Topic; D007269:Injections, Intra-Arterial; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010101:Oxygen Consumption; D010103:Oxygen Isotopes
chemical_list: D010103:Oxygen Isotopes