[Spontaneous and GHRH-induced nocturnal GH secretion in a child population with insulin dependent diabetes mellitus].
It has been studied integrated nocturnal secretion of GH after GHRH test in 15 diabetic children and 10 short stature children with normal GH secretion. The most important findings are: 1) The integrated nocturnal secretion of GH was significantly higher in diabetics than in controls (6.27 +/- 3.11 ngrs/ml/min versus 3.06 +/- 1.41 ngrs/ml/min P [symbol; see text] 0.01). 2) After an acute stimulous with GHRH, diabetic population shows an exaggerated secretion of G. H. during the first 90 minutes compared with control population (33.20 +/- 12.41 ngrs/ml/min versus 18.18 +/- 11.09 P [symbol; see text] 0.01). 3) Both higher spontaneous secretion of G. H., and after GHRH test, are independent of metabolic control (mean nocturnal glycemies and HBA1) and evolution time of disease.
Ruibal Francisco
J L
JL
Departamento de Pediatría, Hospital Universitario San Carlos, Madrid.
Seara Aguilar
G
G
Fernández Méndez
M
M
Reverte Blanc
F
F
Barabash Bustelo
A
A
Borque Ibarra
M
M
Cabranes Díaz
J A
JA
Casado de Frías
E
E
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D012636:Secretory Rate / Q000187:drug effects
D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone
Secreción de G. H. nocturna espontánea y tras GHRH en una población de niños con diabetes mellitus insulino-dependiente.