title: Prevention of the rise in intraocular pressure following neodymium-YAG posterior capsulotomy using topical clonidine.
abstract: We studied the ability of topical clonidine, an alpha-agonist, to suppress the acute rise in intraocular pressure (IOP) following neodymium-YAG posterior capsulotomy (YPC). In a randomized controlled trial 63 eyes were pretreated with one drop of either 0.25% clonidine or saline 1 h before performing YPC and immediately following the procedure. The greatest IOP rise in the saline treated eyes occurred in the second hour after YPC, when the mean (+/- SD) IOP rose from a baseline pressure of 12.7 +/- 3.2 to 18.7 +/- 10.7 mmHg. In clonidine treated eyes, the IOP fell from a mean of 11.9 +/- 3.4 to 9 +/- 3.3 mmHg 2 h postoperatively. In the saline treated group 9 eyes (27%) developed an IOP rise greater than 10 mmHg. Clonidine proved to be highly effective in preventing the rise in IOP following YPC.
authors.affiliation: Department of Ophthalmology, Ichilov Hospital, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Loewenstein
authors.forename: D
authors.initials: D
authors.lastname: Varssano
authors.forename: M
authors.initials: M
authors.lastname: Lazar
authors.forename: O
authors.initials: O
authors.lastname: Geyer
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D002387:Cataract Extraction; D003000:Clonidine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D003000:Clonidine