Aplastic anemia associated with systemic lupus erythematosus.
Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood cells. We report a case of aplastic anemia associated with SLE observed during the remission phase of SLE 3 months after the beginning of treatment. CD8+ T cells in the patient's bone marrow may have suppressed maturation of hematopoietic progenitor cells, which may have induced the aplastic anemia associated with SLE. Repeated therapy with high-dose methylprednisolone resulted in lasting remission.
Sumimoto
S
S
Department of Pediatrics, Sumitomo Hospital, Osaka, Japan.
Kawai
M
M
Kasajima
Y
Y
Hamamoto
T
T
D000741:Anemia, Aplastic / Q000150:complications* / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016827:CD8 Antigens