[Clinicopathological features of metastatic pulmonary calcinosis with malignant neoplasm].
Metastatic pulmonary calcinosis is a rare complication seen in malignancies accompanied by hypercalcemia, or chronic renal failure. We reviewed the clinicopathological findings of 8 cases of metastatic pulmonary calcinosis accompanied malignancy revealed at autopsy. The underlying diseases were malignant lymphoma in 3 cases (adult T cell lymphoma in 2 cases), multiple myeloma in 2, lung cancer in 2, and acute myelocytic leukemia in 1, all cases were complicated by hypercalcemia and renal failure. Chest X-ray revealed almost normal findings in 2 cases, bilateral diffuse infiltrates in 4, bilateral infiltrates in the apex in 1, and right atelectasis in 1. Bone scintigraphy was performed in 4 cases, and revealed warm pulmonary uptake in 1 patient with multiple myeloma and 1 with lung cancer, but normal findings in the 2 other cases. Histopathological examination revealed diffuse alveolar septal edema and fibrosis due to calcium deposition, which were considered to be the cause of respiratory failure. Metastatic pulmonary calcinosis is a rare but a serious complication in malignancies accompanied by hypercalcemia and renal failure, and bone scintigraphy seems to be a useful method for its diagnosis.
Nambu
Y
Y
Department of Respiratory Medicine, Tenri Hospital, Nara, Japan.
Iwata
T
T
Oida
K
K
Kohri
Y
Y
Taguchi
Y
Y
Tomii
K
K
Mino
M
M
Yunoki
Y
Y
Ichijima
K
K
Kobashi
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002114:Calcinosis / Q000473:pathology*; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications; D007674:Kidney Diseases / Q000150:complications; D007938:Leukemia / Q000473:pathology; D008171:Lung Diseases / Q000473:pathology*; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology; D011650:Pulmonary Alveoli / Q000473:pathology