X-linked mental retardation with bilateral clasped thumbs: report of another affected family.
A Sephardi Jewish family is reported in which the two brothers had mental retardation, lower limb spasticity and bilateral clasped thumbs anomaly. This X-linked recessive disorder has only been reported twice. We believe this syndrome comprises a distinct entity among the X-linked mental retardation syndromes.
Straussberg
R
R
Department of Pediatrics, Hasharon Hospital, Petach-Tikvah, Israel.
Blatt
I
I
Brand
N
N
Kessler
D
D
Katznelson
M B
MB
Goodman
R M
RM
D000293:Adolescent; D002648:Child; D008040:Genetic Linkage; D006228:Hand Deformities, Congenital / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008297:Male; D010375:Pedigree; D013933:Thumb / Q000002:abnormalities*; D014960:X Chromosome