title: A 102-center prospective study of seizure in association with bupropion.
abstract: BACKGROUND
  This trial was conducted to determine the incidence of seizures associated with the use of bupropion.
  
  
  METHODS
  A total of 3341 depressed patients from 102 sites were enrolled in this 8-week, prospective, open trial. Following the 8-week treatment phase, patients could elect to enroll in a humanitarian continuation phase of unlimited duration. Dosing was initiated at 225 mg/day and increased to 450 mg/day as tolerated. Investigators carefully monitored seizure occurrences and rated their patients' response to and tolerance of bupropion.
  
  
  RESULTS
  A total of 1986 patients (61%) completed the 8-week treatment phase, and 1616 (81%) of these elected to be maintained on bupropion treatment in the humanitarian continuation phase. The observed seizure rate was 0.24% for the treatment phase and 0.40% for the entire study. An 8-week survival analysis performed on patients with a dosing regimen of 300 to 450 mg/day yielded a cumulative rate of 0.36%. Patients, including those previously resistant to antidepressant treatment, responded to and tolerated bupropion well.
  
  
  CONCLUSIONS
  These rates confirm earlier seizure estimates and fall within accepted parameters for antidepressant drugs. This trial enhances bupropion's position as a valuable alternative for the management of depression.
authors.affiliation: Burroughs Wellcome Co., Research Triangle Park, NC 27709.
authors.forename: J A
authors.initials: JA
authors.lastname: Johnston
authors.forename: C G
authors.initials: CG
authors.lastname: Lineberry
authors.forename: J A
authors.initials: JA
authors.lastname: Ascher
authors.forename: J
authors.initials: J
authors.lastname: Davidson
authors.forename: M A
authors.initials: MA
authors.lastname: Khayrallah
authors.forename: J P
authors.initials: JP
authors.lastname: Feighner
authors.forename: P
authors.initials: P
authors.lastname: Stark
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016642:Bupropion / Q000009:adverse effects* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012640:Seizures / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D016642:Bupropion