title: Effects of systemic glucose injection on the development of amygdala kindling in rats.
abstract: The effects of systemic glucose administration on the development of electric amygdaloid kindling seizures were examined in Wistar rats. Daily intraperitoneal injections of glucose 100 mg/kg, 20 min prior to each amygdaloid stimulation did affect the rate of kindling development in comparison with the saline-injected group. The number of stimulations required to reach stage 5 was lower in animals treated with glucose. The facilitation of kindling development found in glucose-treated rats is related to a specific decrease in the number of stimulations needed to evolve from stage 2 to stage 3. These results indicate that systemic glucose administration facilitates amygdaloid kindling in rats.
authors.affiliation: Laboratório de Neurologia Experimental, Escola Paulista de Medicina, São Paulo, Brasil.
authors.forename: M R
authors.initials: MR
authors.lastname: Priel
authors.forename: Z A
authors.initials: ZA
authors.lastname: Bortolotto
authors.forename: E A
authors.initials: EA
authors.lastname: Cavalheiro
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D001931:Brain Mapping; D005950:Glucose Solution, Hypertonic; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001786:Blood Glucose; D005950:Glucose Solution, Hypertonic