Keratinocyte cytokines.
It is now clear that keratinocytes produce a wide range of cytokines that can be regarded as important mediators of intercellular communication. A major emphasis has been placed on IL-1 because of its relationships with other cytokines and other differentiated tissues. Dysregulation of IL-1, IL-1 receptor, and inhibitory factors for IL-1 may cause imbalance of skin biology, leading to perpetuation of immune and inflammatory events. Interaction of IL-1 with other cytokines in vivo is also important in the understanding of the pathophysiology of skin diseases. More fundamental questions regarding the homeostatic significance of IL-1 in keratinocytes still remain to be answered.
Nozaki
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Department of Dermatology, Showa University, Tokyo, Japan.
Feliciani
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Sauder
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D003115:Colony-Stimulating Factors / Q000502:physiology; D016207:Cytokines / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007375:Interleukin-1 / Q000235:genetics / Q000502:physiology; D007378:Interleukins / Q000502:physiology; D015603:Keratinocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology*
D003115:Colony-Stimulating Factors; D016207:Cytokines; D006133:Growth Substances; D007375:Interleukin-1; D007378:Interleukins