title: Single dose of labetalol in hypertensive pregnancy: effects on maternal hemodynamics and uterine and fetal flow velocity waveforms.
abstract: The short-term effect of 0.8 mg/kg of an intravenous bolus of labetalol on maternal and fetal hemodynamics was investigated in ten women with pregnancy-induced hypertension. The maximum effect occurred within 35 minutes after labetalol administration. At that point, the mean arterial pressure had decreased by 18% and there was a slight decrease in maternal heart rate. As to flow velocity waveforms, no significant change was found in mean systolic/diastolic (S/D) ratio of the uterine artery, umbilical artery or fetal middle cerebral artery. However, in two subjects with a marked reduction in blood pressure also the uterine artery S/D ratio decreased.
authors.affiliation: Department of Obstetrics and Gynecology, Turku University Central Hospital, Finland.
authors.forename: J P
authors.initials: JP
authors.lastname: Pirhonen
authors.forename: R U
authors.initials: RU
authors.lastname: Erkkola
authors.forename: J I
authors.initials: JI
authors.lastname: Mäkinen
authors.forename: U U
authors.initials: UU
authors.lastname: Ekblad
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000098:blood supply*; D006339:Heart Rate / Q000187:drug effects; D006340:Heart Rate, Fetal / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006973:Hypertension / Q000188:drug therapy*; D007275:Injections, Intravenous; D007741:Labetalol / Q000494:pharmacology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D013997:Time Factors; D014599:Uterus / Q000098:blood supply*
chemical_list: D007741:Labetalol