title: Mucosal surface area of a reversed intestinal segment in rats.
abstract: Only scarce knowledge exists of morphologic changes after antiperistaltic reversal of the small intestine. Previous animal models using a reversed segment of the small intestine after massive intestinal resection have been mostly concerned with assessing absorption. A rat model was therefore developed for the purpose of studying mucosal surface area in the small intestine after reversal of an intestinal segment. A reversal of 10 cm, representing a length of about 10%, was found suitable for the investigation. Marked dilatation of the reversed segment occurred. A pronounced increase in mucosal surface area caused by mucosal hyperplasia was observed. The mucosal surface area in an anastomosed, but not reversed, segment also increased markedly compared with a group undergoing no operation, although less than in the reversed segment. We conclude that a reversed intestinal segment will increase mucosal surface area in an optimal length used for this purpose. This increase is possibly caused by prolonged exposure to intestinal chyme.
authors.affiliation: Dept. of Surgery, Rogaland Central County Hospital, Stavanger, Norway.
authors.forename: K
authors.initials: K
authors.lastname: Søndenaa
authors.forename: I
authors.initials: I
authors.lastname: Nesvik
authors.forename: K
authors.initials: K
authors.lastname: Nygaard
authors.forename: T
authors.initials: T
authors.lastname: Sauer
mesh_terms: D000818:Animals; D004108:Dilatation, Pathologic / Q000473:pathology; D005260:Female; D006965:Hyperplasia; D006984:Hypertrophy; D007413:Intestinal Mucosa / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery*; D009130:Muscle, Smooth / Q000473:pathology; D010528:Peristalsis / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012778:Short Bowel Syndrome / Q000601:surgery; D013997:Time Factors