title: Nondestructive analysis of mitral valve collagen fiber orientation.
abstract: Collagen is the most abundant and highest modulus component in mitral valve (MV) tissue. MV leaflet and chordal collagen ultrastructure were analyzed by small angle light scattering (SALS) and polarized light microscopy (PLM) to provide collagen fiber architecture mapping. It was hypothesized that structural arrangement strongly influences MV tissue mechanical properties and thus physiologic function.
authors.affiliation: Joint Program in Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas.
authors.forename: R P
authors.initials: RP
authors.lastname: Cochran
authors.forename: K S
authors.initials: KS
authors.lastname: Kunzelman
authors.forename: C J
authors.initials: CJ
authors.lastname: Chuong
authors.forename: M S
authors.initials: MS
authors.lastname: Sacks
authors.forename: R C
authors.initials: RC
authors.lastname: Eberhart
mesh_terms: D008841:Actin Cytoskeleton / Q000648:ultrastructure*; D000818:Animals; D003094:Collagen / Q000032:analysis*; D008859:Microscopy, Polarization; D008943:Mitral Valve / Q000473:pathology*
chemical_list: D003094:Collagen