Kinetics of Saccharomyces cerevisiae elimination from the intestines of human volunteers and effect of this yeast on resistance to microbial colonization in gnotobiotic mice.
When healthy volunteers were given a daily dose of 3 x 10(8) life-dehydrated Saccharomyces cerevisiae cells for 5 days, the volunteers excreted 10(5) living yeast cells per g of feces at first, but the yeast cells disappeared within 5 days of the end of treatment. In gnotobiotic mice, S. cerevisiae administered alone colonized the intestinal tract but did not interfere with previous or subsequent colonization by a variety of potentially enteropathogenic microorganisms. When these microorganisms were present, the intestinal counts of S. cerevisiae were greatly reduced.
Pecquet
S
S
Laboratoire de Microbiologie, Faculté de Pharmacie, Chatenay-Malabry, France.
Guillaumin
D
D
Tancrede
C
C
Andremont
A
A
D000328:Adult; D000818:Animals; D015169:Colony Count, Microbial; D005243:Feces / Q000382:microbiology; D005856:Germ-Free Life; D006801:Humans; D007408:Intestinal Absorption; D007422:Intestines / Q000382:microbiology* / Q000648:ultrastructure; D007700:Kinetics; D051379:Mice; D008809:Mice, Inbred C3H; D012441:Saccharomyces cerevisiae / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure