[Problems in evaluating the efficacy of treatment of sudden deafness].
1) The indices of hearing recovery for sudden deafness was examined. Because it did not reflect the severity of the initial hearing loss, the standard of the Japanese Ministry of Welfare was thought to be inadequate. 2) Since the prognosis of sudden deafness was known to be influenced by several factors, it seemed to be necessary for evaluating the efficacy of treatment to exclude various modifying factors. For this purpose predicting hearing recovery based on multiple regression analysis is appropriate. 3) The predicting recovery rate with the actual recovery rate for 4 kinds of treatment was compared. No significant difference was found between the expected values and the observed values. 4) The scatter diagram indicated 2 groups of patients. This might be due to different pathophysiology of sudden deafness. In the good recovery group, the recovery rate for prostaglandin E1 therapy was significantly better than the expected one.
Taiji
H
H
Department of Otolaryngology, Keio University School of Medicine, Tokyo.
Kanzaki
J
J
D000328:Adult; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006320:Hearing Tests; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D012044:Regression Analysis; D016896:Treatment Outcome