title: [Isosorbide dinitrate tolerance in the treatment of patients with angina pectoris and the effect of addition of captopril on therapeutic results].
abstract: The authors investigated in patients with stable angina the influence of a single dose and of long-term administration of isosorbide dinitrate alone and combined with captopril. Administration of 40 mg Iso-Mack ret. every 8 hours for four weeks did not lead to the development of tolerance. However, captopril added to isosorbide dinitrate tends to improve the investigated indicators after a single dose as well as after long-term treatment. It is probable that concurrent administration of the two drugs causes addition of their vasodilatating action and thus the vascular resistance declines, as well as the cardiac pre-load and after-load and the oxygen consumption of the heart muscle. The authors discuss possible mechanisms of the increased vasodilatation after addition of captopril.
authors.affiliation: I. klinika vnitrních chorob lékarské fakulty Masarykovy univerzity, Brno-Bohunice.
authors.forename: P
authors.initials: P
authors.lastname: Rotrekl
authors.forename: Z
authors.initials: Z
authors.lastname: Lupínek
authors.forename: J
authors.initials: J
authors.lastname: Meluzín
authors.forename: M
authors.initials: M
authors.lastname: Novák
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002216:Captopril / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
chemical_list: D002216:Captopril; D007548:Isosorbide Dinitrate
vernacular_title: Otázka tolerance pri lécbĕ nemocných s anginou pectoris isosorbiddinitrátem a vliv na výsledky této lécby po pridávání captoprilu.