The use of porcine factor VIII in the treatment of patients with acquired hemophilia: the United Kingdom experience.
Data have been collected by questionnaire on 15 acute bleeding episodes in 12 patients with acquired hemophilia, treated with porcine factor VIII (FVIII). The median initial anti-human FVIII inhibitor level was 40 Bethesda Units (BU)/ml, whereas that against porcine was 1 BU/ml. The mean initial dose of porcine FVIII infused was 54 micrograms/kg, which resulted in a rise of 0.57 IU/mL in the FVIII concentration. Therapy was continued for a mean of 8.5 days, during which time the average number of infusions was 11. Clinical response was rated as good or excellent in 82% of recipients. Side effects were uncommon; only one patient experienced a severe reaction. Following therapy, no increase in antihuman antibody levels was noted; increased levels of antiporcine antibody was detected in only two patients. One patient bled on three further occasions and was successfully retreated with porcine FVIII. Porcine FVIII is a safe and clinically effective treatment for bleeding episodes in acquired hemophilia and should be considered as first-line therapy for patients with low antiporcine FVIII levels.
Morrison
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AE
Department of Haematology, Royal Infirmary, Edinburgh, Scotland, United Kingdom.
Ludlam
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CA
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology; D005169:Factor VIII / Q000276:immunology / Q000627:therapeutic use*; D006470:Hemorrhage / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D006801:Humans; D013552:Swine
D001323:Autoantibodies; D005169:Factor VIII