Protective effects of TJ-960 herbal mixture on hippocampal neuron damage induced by cobalt focus in the cerebral cortex of rats.
In the cobalt focus experimental epilepsy model, severe hippocampal neuron damage occurs with marked EEG changes. The effects of TJ-960, a herbal medicine formulation, were studied on neuron damage in the CA1 area of rat hippocampus. Continuous oral administration of TJ-960 from one month prior to the cobalt application showed almost complete protection against hippocampal neuron damage induced by cobalt application to the cerebral cortex. TJ-960 also completely inhibited the EEG changes as well as the brain edema induced by cobalt application.
Sugaya
E
E
Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
Ishige
A
A
Sekiguchi
K
K
Yuzurihara
T
T
Iizuka
S
S
Sugimoto
A
A
Takeda
S
S
Wakui
Y
Y
Ishihara
K
K
Aburada
M
M
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001834:Body Water / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003035:Cobalt; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000187:drug effects*; D011712:Pyramidal Tracts / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; C461321:shosaikoto-go-keishika-shakuyakuto; D003035:Cobalt