title: Topical administration of cyclosporine for treatment of keratoconjunctivitis sicca in dogs.
abstract: Sixty dogs with chronic keratoconjunctivitis sicca were treated by topical administration of 2% cyclosporine twice daily. Causes and duration of keratoconjunctivitis varied. Tear production improved in 75 of 100 eyes, and corneal pigmentation decreased in 45 of 67 eyes. Six factors were evaluated to determine their influence on treatment outcome. The only significant variable was the initial Schirmer tear test value. Side effects were few. Evidence of burning in response to application of cyclosporine resolved with change in the formulation of the topical solution.
authors.affiliation: Angell Memorial Animal Hospital, Boston, MA 02130.
authors.forename: R V
authors.initials: RV
authors.lastname: Morgan
authors.forename: K L
authors.initials: KL
authors.lastname: Abrams
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001947:Breeding; D002908:Chronic Disease; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D005500:Follow-Up Studies; D007638:Keratoconjunctivitis Sicca / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009883:Ophthalmic Solutions; D013666:Tears / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D009883:Ophthalmic Solutions; D016572:Cyclosporine