title: [Lactase deficiency and lactose intolerance-related symptoms in adult healthy subjects from western France].
abstract: The prevalence of lactase deficiency (LD) and lactose intolerance is not well known in France. Using breath hydrogen and methane analysis after 50 g oral lactose load, we investigated the prevalences of LD, lactose intolerance, and methane producer status in 102 healthy adults born in western France, and we examined the relationships between these parameters and the daily milk consumption. In 10 subjects with LD and lactose intolerance, we studied the reproducibility of the lactose hydrogen breath test results for the diagnosis of LD and lactose intolerance and estimated the quantity of lactose malabsorbed in comparison with the lactulose hydrogen breath test. The prevalence of LD was 23.4 percent and symptoms of lactose intolerance were observed in 50 percent of the 24 subjects with LD. The daily milk consumption was not significantly different in the 24 subjects with LD and in the 78 subjects without LD (281 +/- 197 vs 303 +/- 217 ml/24 h). The prevalence of methane producer status was 42.1 percent. The symptomatic group of lactose malabsorbers (n = 12) was characterized by a shorter lactose mouth to caecum transit time (39 +/- 20 vs 88 +/- 48 min; P less than 0.05), and more marked hydrogen production (6.1 +/- 2.3 vs 3.4 +/- 2.4 10(3) ppm.min; P less than 0.04). In the 10 subjects with LD and lactose intolerance, the hydrogen breath test was reproducible for diagnosis of LD and lactose intolerance, and for hydrogen production. The quantity of lactose malabsorbed was 60 percent. In France, symptoms of lactose intolerance are not severe and do not affect the daily consumption of milk and dairy products.
authors.affiliation: Groupe Fonctions Digestives et Nutrition, Centre de Recherches sur Volontaires, CHU Nord, Nantes.
authors.forename: D
authors.initials: D
authors.lastname: Cloarec
authors.forename: S
authors.initials: S
authors.lastname: Gouilloud
authors.forename: F
authors.initials: F
authors.lastname: Bornet
authors.forename: S
authors.initials: S
authors.lastname: Bruley des Varannes
authors.forename: Y
authors.initials: Y
authors.lastname: Bizais
authors.forename: J P
authors.initials: JP
authors.lastname: Galmiche
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000293:Adolescent; D000328:Adult; D003967:Diarrhea / Q000209:etiology; D005260:Female; D005414:Flatulence / Q000209:etiology; D005602:France; D006801:Humans; D006859:Hydrogen / Q000493:pharmacokinetics; D007787:Lactose Intolerance / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000378:metabolism; D007789:Lactose Tolerance Test / Q000379:methods; D008297:Male; D015995:Prevalence; D012016:Reference Values; D015203:Reproducibility of Results; D001616:beta-Galactosidase / Q000172:deficiency* / Q000378:metabolism
chemical_list: D006859:Hydrogen; D001616:beta-Galactosidase
vernacular_title: Déficit en lactase et symptômes d'intolérance au lactose dans une population adulte saine originaire de l'ouest de la France.