title: Variable (dG-dT)n.(dC-dA)n sequences in the porcine genome.
abstract: One of the more widely studied simple repeat sequences in the mammalian genome is the (dG-dT)n.(dC-dA)n dinucleotide repeat sequence. As these repeats are highly polymorphic and fairly evenly distributed in diverse mammalian genomes, they constitute a very powerful tool for genetic mapping in a wide variety of species. So far, the knowledge about repeat sequences in the porcine genome is sparse and only a few areas of this genome have been sequenced. We have isolated and characterized 108 porcine (dG-dT)n.(dC-dA)n sequences and studied the distribution of these, both by investigating random clones and by performing in situ hybridization. A remarkable correlation between humans and pigs was found with respect to the structure, to the number of repeat blocks, and to the chromosomal distribution.
authors.affiliation: Department of Animal Production and Animal Health, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
authors.forename: A K
authors.initials: AK
authors.lastname: Winterø
authors.forename: M
authors.initials: M
authors.lastname: Fredholm
authors.forename: P D
authors.initials: PD
authors.lastname: Thomsen
mesh_terms: D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics; D005784:Gene Amplification; D015723:Gene Library; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D013552:Swine / Q000235:genetics*
chemical_list: D004247:DNA