title: Ampicillin concentrations in human oral tissues following a single oral administration of lenampicillin.
abstract: 1. Ampicillin concentrations in serum (n = 20), gingiva (n = 12), jawbone (n = 13), dental follicle (n = 12), radicular granuloma (n = 2) and radicular cyst (n = 2) were measured in specimens obtained during 0.5-2.5 hr after a single oral administration of lenampicillin (equivalent to 500 mg of ampicillin). 2. Measurable ampicillin concentrations were found in all serum and tissues. 3. Ampicillin concentrations in serum and tissues except for some gingiva and jawbone exceeded MIC for 90% of clinically isolated strains of alpha-hemolytic Streptococci. 4. Ampicillin concentrations in gingiva and jawbone were below the MIC for 90% in 2 out of 12 and 4 out of 13 specimens, respectively.
authors.affiliation: Second Department of Oral Surgery, Nihon University School of Dentistry, Chiba, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Mochizuki
authors.forename: A
authors.initials: A
authors.lastname: Uda
authors.forename: H
authors.initials: H
authors.lastname: Omata
authors.forename: J
authors.initials: J
authors.lastname: Shibutani
authors.forename: K
authors.initials: K
authors.lastname: Kaneko
authors.forename: J
authors.initials: J
authors.lastname: Yamane
authors.forename: A
authors.initials: A
authors.lastname: Fujii
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D003795:Dental Sac / Q000378:metabolism; D005260:Female; D005881:Gingiva / Q000378:metabolism; D006801:Humans; D007568:Jaw / Q000378:metabolism; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009055:Mouth / Q000378:metabolism*; D011842:Radicular Cyst / Q000378:metabolism; D013291:Streptococcus / Q000187:drug effects
chemical_list: D000667:Ampicillin; C045384:lenampicillin