Immune response of the Mongolian gerbil (Meriones unguiculatus) to sheep red blood cells.
The immune responses of Mongolian gerbils, Meriones unguiculatus, to sheep red blood cells (SRBC) were studied as compared to those of mice. After a single injection of SRBC, hemagglutinin titers in gerbils were significantly lower and hemolytic plaque-forming cells (PFC) in the spleen were less in number as compared to the response of mice. In gerbils the PFC response to a higher dose of bacterial lipopolysaccharide (LPS) was rather higher than in mice. The delayed-type hypersensitivity (DTH) assay on the foot-pad revealed that the responsiveness was considerably lower in gerbils than in mice.
Yukawa
M
M
Laboratory of Biomedical Science, College of Agriculture and Veterinary Medicine, Nihon University, Tsukuba, Japan.
Onodera
T
T
Yoshihara
K
K
Saitoh
H
H
Mochizuki
K
K
D000818:Animals; D004912:Erythrocytes / Q000276:immunology*; D005849:Gerbillinae / Q000276:immunology*; D006386:Hemagglutination Tests; D006388:Hemagglutinins / Q000096:biosynthesis*; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000662:veterinary*; D008297:Male; D012756:Sheep
D006388:Hemagglutinins; D006460:Hemolysin Proteins