title: Hemophagocytic syndrome associated with aggressive natural killer cell leukemia.
abstract: We describe a patient who had aggressive natural killer cell leukemia with profound hemophagocytosis. This combination must be underscored as one of several hemophagocytic syndromes. Activated phagocytes in the bone marrow appeared morphologically normal and could possibly be proliferating in response to some cytokine(s) such as interferon-gamma produced by leukemic cells, whose serum level was found to be extremely elevated in this case.
authors.affiliation: Department of Internal Medicine, Saiseikai Suita General Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Okuda
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: T
authors.initials: T
authors.lastname: Deguchi
authors.forename: S
authors.initials: S
authors.lastname: Misawa
authors.forename: K
authors.initials: K
authors.lastname: Kashima
authors.forename: T
authors.initials: T
authors.lastname: Yoshihara
authors.forename: S
authors.initials: S
authors.lastname: Ikushima
authors.forename: S
authors.initials: S
authors.lastname: Hibi
authors.forename: S
authors.initials: S
authors.lastname: Imashuku
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications*; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D007938:Leukemia / Q000150:complications* / Q000473:pathology; D016131:Lymphocyte Subsets / Q000473:pathology
chemical_list: D015703:Antigens, CD