The effect of tubal injection of methotrexate on fertility in the rabbit.
OBJECTIVE
To investigate the fertility of rabbits after tubal injection of methotrexate (MTX).


METHODS
The side of injection of MTX was randomly decided in a prospective experimental trial.


METHODS
Fourteen female New Zealand White Rabbits were believed to be of normal reproductive status.


METHODS
Methotrexate or Ringer's solution were injected into the tubes of the rabbits. The nidation index was used to measure the fertility of the animals.


RESULTS
The average nidation index of the control tubes was not statistically different of the one of the tubes treated with MTX.


CONCLUSIONS
Tubal injection of MTX has no adverse effect on fertility of rabbits. It seems ethical to investigate tubal injection of MTX as an alternative to laparoscopic management of unruptured ectopic pregnancy in the human.
Lecuru
F
F
Clinique Universitaire de Gynécologie-Obstétrique, Pavillon Paul Gellé, Roubaix, France.
Querleu
D
D
Buchet-Bouverne
B
B
Subtil
D
D
D000818:Animals; D005187:Fallopian Tubes; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007267:Injections; D008727:Methotrexate / Q000008:administration & dosage* / Q000494:pharmacology; D011247:Pregnancy; D011817:Rabbits
D008727:Methotrexate