Responses of atrium and ventricle to sustained sympathetic nerve stimulation.
To determine whether chronotropic and atrial inotropic responses to sympathetic nerve stimulation are maintained longer than ventricular inotropic response, the present study was performed with control and acute reserpinized dogs. We stimulated the right stellate ganglion of both groups supramaximally for 60 min and compared right atrial responses (chronotropism and inotropism) with left ventricular (LV) dP/dtmax. In the control group, heart rate (HR) immediately increased and was only slightly attenuated with 60 min of stimulation, and right atrial (RA) inotropic response was less attenuated than was LV response (7% in HR, 33% in RA dP/dtmax, 50% in LV dP/dtmax, P less than 0.01, from the peak value of each response). RA and LV norepinephrine (NE) content was decreased by the stimulation but remained higher than the LV control value. In the reserpinized group, NE content in the RA was low before the stimulation and was further decreased by the stimulation. In this group, HR response was attenuated (27% in HR, P less than 0.01) as was LV dP/dtmax, and the difference in contractile responsiveness between atrium and ventricle disappeared (58% in RA dP/dtmax vs. 61% in LV dP/dtmax, NS). The results indicate that the chronotropic response was only slightly attenuated and that the atrial contractile response was attenuated less than the ventricular response, with sustained sympathetic nerve stimulation in the normal heart. This can be ascribed to the much higher NE content in the RA than that in the LV.
Furuyama
M
M
First Department of Internal Medicine, Tohoku University School of Medicine, Miyagi, Japan.
Haneda
T
T
Ikeda
J
J
Hiramoto
T
T
Sakuma
T
T
Kanda
H
H
Shirato
K
K
Takishima
T
T
D000818:Animals; D016275:Atrial Function / Q000502:physiology*; D004285:Dogs; D004558:Electric Stimulation; D006321:Heart / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D011312:Pressure; D012110:Reserpine / Q000494:pharmacology; D013233:Stellate Ganglion / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*; D016276:Ventricular Function / Q000502:physiology*; D016277:Ventricular Function, Left / Q000502:physiology
D012110:Reserpine; D009638:Norepinephrine