Proopiomelanocortin expression in the skin during induced hair growth in mice.
We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti beta-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, beta-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.
Slominski
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A
Department of Immunology and Microbiology, Albany Medical College, New York 12202.
Paus
R
R
Mazurkiewicz
J
J
D000818:Animals; D015152:Blotting, Northern; D015153:Blotting, Western; D005260:Female; D005786:Gene Expression Regulation; D006197:Hair / Q000254:growth & development* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D011333:Pro-Opiomelanocortin / Q000096:biosynthesis / Q000235:genetics* / Q000502:physiology; D014176:Protein Biosynthesis; D012867:Skin / Q000737:chemistry / Q000378:metabolism; D012879:Skin Physiological Phenomena
D011333:Pro-Opiomelanocortin