title: Studies on the isotetracenone antibiotics. IV. Hatomarubigins A, B, C and D, new isotetracenone antibiotics effective against multidrug-resistant tumor cells.
abstract: A complex of new isotetracenone group antibiotics was isolated from the cultured broth of Streptomyces sp. 2238-SVT4. It consisted of four related compounds, designated hatomarubigins A, B, C and D, whose structures were elucidated by NMR spectral analysis including a variety of 2D techniques. They enhanced the cytotoxicity of colchicine against multidrug-resistant tumor cells.
authors.affiliation: Institute of Applied Microbiology, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayakawa
authors.forename: S C
authors.initials: SC
authors.lastname: Ha
authors.forename: Y J
authors.initials: YJ
authors.lastname: Kim
authors.forename: K
authors.initials: K
authors.lastname: Furihata
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; C072148:hatomarubigin B; C072152:hatomarubigin C; C072153:hatomarubigin D; C072147:hatomarubigin A