Effect of indomethacin on selected immune parameters in different age groups of mice.
The authors studied the effect of indomethacin on the phagocytic activity of polymorphonuclear leucocytes (PMNL) and on haemolytic antibody formation (plaques) by lymphoid cells of the spleen in 3-, 6- and 12-month-old mice. In 3- and 12-month-old animals the phagocytic activity of the PMNL was significantly inhibited. Plaque formation was likewise significantly inhibited in 3-month-old mice, but it was significantly raised in 6- and 12-month-old animals.
Mahel'ová
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O
Department of Pharmacology, Faculty of Medicine, Safárik University, Kosice.
Linková
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A
D000375:Aging / Q000502:physiology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D007107:Immune System / Q000187:drug effects / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D013154:Spleen / Q000378:metabolism
D007213:Indomethacin