Inhibition of prostaglandin synthetase alters uterine response to adrenoceptor agonists in pregnant and post-partum rats.
1. The involvement of intramurally generated prostaglandins in uterine response to adrenoceptor agonists has been investigated in rats during late pregnancy and post partum. 2. Both adrenaline and salbutamol (10(-9)-3 x 10(-7) M) produced concentration-dependent inhibition of acetylcholine-induced tone in preparations from 20-day pregnant and 1-day post-partum rats. 3. Inhibition of prostaglandin synthetase with flurbiprofen enhanced uterine response to these agonists in late pregnancy and post partum. 4. In endometrium-free preparations, flurbiprofen treatment had no significant effect on myometrial responses to adrenaline and salbutamol, suggesting a role for the endometrium in the interaction between adrenoceptor agonists and the prostaglandin synthetase pathway. 5. The above results provide pharmacological evidence for the involvement of prostaglandins in rat uterine response to adrenoceptor agonists during pregnancy and post partum.
al-Zadjali
K H
KH
Department of Pharmacology, University of Glasgow, Scotland.
Boyle
F C
FC
Ohia
S E
SE
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000420:Albuterol / Q000494:pharmacology; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013566:Sympathomimetics / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D016861:Cyclooxygenase Inhibitors; D013566:Sympathomimetics; D005480:Flurbiprofen; D011451:Prostaglandin-Endoperoxide Synthases; D000109:Acetylcholine; D000420:Albuterol; D004837:Epinephrine