title: Dental plaque: a permanent reservoir of Helicobacter pylori?
abstract: The aim of the study was to observe the relationship between the two reservoirs of Helicobacter pylori--that is, dental plaque and the stomach. With the Campylobacter-like organism (CLO) test, H. pylori was detected in dental plaque and in gastric antral and body mucosa in 98%, 67% and 70%, respectively, of 43 consecutive patients with dyspepsia. The rapidity of the CLO test indicates that the density of H. pylori is heaviest in dental plaque, less in the antrum, and least in the body mucosa of the stomach. Triple drug therapy (bismuth, tinidazole, and amoxycillin or doxycycline) was administered for 15 days to 24 patients. By the CLO test, H. pylori was eliminated from the gastric mucosa in all 24 patients but persisted in dental plaque in all of them. Our observations indicate that dental plaque is unaffected by triple drug therapy and is perhaps a permanent reservoir of H. pylori if local therapy also fails to eradicate the organism.
authors.affiliation: Dept. of Gastroenterology, B.Y.L. Nair Charitable Hospital, Bombay, India.
authors.forename: H G
authors.initials: HG
authors.lastname: Desai
authors.forename: H H
authors.initials: HH
authors.lastname: Gill
authors.forename: K
authors.initials: K
authors.lastname: Shankaran
authors.forename: P R
authors.initials: PR
authors.lastname: Mehta
authors.forename: S R
authors.initials: SR
authors.lastname: Prabhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D000863:Antacids / Q000627:therapeutic use; D003773:Dental Plaque / Q000382:microbiology*; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D005756:Gastritis / Q000188:drug therapy / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use; D013270:Stomach / Q000382:microbiology; D014011:Tinidazole / Q000627:therapeutic use
chemical_list: D000863:Antacids; D009942:Organometallic Compounds; D014011:Tinidazole; D000658:Amoxicillin; C002791:bismuth tripotassium dicitrate; D004318:Doxycycline