title: Relevance of vitamin D metabolite concentrations in supporting the diagnosis of primary hyperparathyroidism.
abstract: We compared the relationships between 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in patients with primary hyperparathyroidism (PHPT) and 38 volunteer blood donors. There was no significant difference in mean 25(OH)D levels between patients with PHPT (34 +/- 21 nmol/L; n = 21) and the donor samples (41 +/- 19 nmol/L; n = 38). Serum 1,25(OH)2D levels were higher in the patients with PHPT compared with the donors (122 +/- 61 pmol/L vs 56 +/- 41 pmol/L; p less than 0.001). The 95th percentile 1,25(OH)2D value for the donors was exceeded in 65% of the patients with PHPT. There was a significant correlation between serum 1,25(OH)2D versus 25(OH)D in the patients with PHPT (r = 0.50; p less than 0.05) but not in the donors (r = 0.02). We conclude from the distinct elevation in 1,25(OH)2D levels in the majority of our patients with PHPT that the concentration of this parathyroid hormone-dependent hormone can be of critical value in corroborating the diagnosis of PHPT.
authors.affiliation: Department of Clinical Biochemistry, University of Toronto, Mount Sinai Hospital, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Vieth
authors.forename: T A
authors.initials: TA
authors.lastname: Bayley
authors.forename: P G
authors.initials: PG
authors.lastname: Walfish
authors.forename: I B
authors.initials: IB
authors.lastname: Rosen
authors.forename: A
authors.initials: A
authors.lastname: Pollard
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D006961:Hyperparathyroidism / Q000097:blood* / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period
chemical_list: D006887:Hydroxycholecalciferols