Role of tumor necrosis factor-alpha in Sneddon-Wilkinson subcorneal pustular dermatosis. A model of neutrophil priming in vivo.
A patient with IgG-kappa-associated subcorneal pustular dermatosis (Sneddon-Wilkinson disease) refractory to dapsone, etretinate, and plasma exchange was successfully treated with corticosteroids. A study of neutrophils from both blood and pustules was carried out before and during treatment. Levels of tumor necrosis factor-alpha were measured in serum, pustules, content, and supernatant of monocytes. The results suggest that a hyperactivation of neutrophils in the skin is due at least partly to excessive production of tumor necrosis factor-alpha.
Grob
J J
JJ
Service de Dermatologie, Hôpital Sainte Marguerite, Marseille, France.
Mege
J L
JL
Capo
C
C
Jancovicci
E
E
Fournerie
J R
JR
Bongrand
P
P
Bonerandi
J J
JJ
D000368:Aged; D000369:Aged, 80 and over; D002465:Cell Movement; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009504:Neutrophils / Q000276:immunology; D010951:Plasma Exchange; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis*
D007074:Immunoglobulin G; D014409:Tumor Necrosis Factor-alpha; D008775:Methylprednisolone