[Stability of cefazolin sodium as eyedrops in various solutions].
Cephazolin sodium prepared with four different solutions (NaCl 0.9%, Protagent, Liquifilm and phosphate buffer) to be used as eye drops, was evaluated as to its physicochemical features at +4 degrees C, +37 degrees C and at room temperature and its activity in terms of minimal inhibition concentration. In conclusion, cephazolin sodium prepared with artificial tears at acidic pH can be kept for 3 days at room temperature and at +4 degrees C without any loss of its activity.
Yildirim
N
N
Anadolu Universitesi, Tip Fakültesi, Göz Hastaliklari Anabilim Dali Oğretim Uyesi.
Topbaş
S
S
Usluer
G
G
Ozgüneş
I
I
Başmak
H
H
Yurdakul
S
S
D002021:Buffers; D002437:Cefazolin / Q000737:chemistry* / Q000494:pharmacology; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D012996:Solutions; D013211:Staphylococcus aureus / Q000187:drug effects*; D013696:Temperature; D013997:Time Factors
D002021:Buffers; D009883:Ophthalmic Solutions; D012996:Solutions; D002437:Cefazolin
Ceşitli sivilar ile göz damlasi olarak hazirlanan sefazolin sodyumun stabilitesi.