Characterization of beta-endorphin-related peptides in the caudal medulla oblongata and hypothalamus of the prenatal, postnatal and adult rat.
A comparison was made of beta-endorphin (B-END) concentrations versus post-translation products during the perinatal period in the hypothalamus and the caudal medulla oblongata. The concentration of B-END-like immunoreactivity did not differ statistically between embryonic day 21 (E21) and postnatal day 1 (P1) in either area. There were significant differences in forms, with a shift from larger precursors at E21 to smaller peptides at P1, with the predominant form of B-END being the 31 residue form at E21 in both regions. B-END varied between the two regions at P1, the 27-26 residue predominant in the hypothalamus, and the 31 residue in the caudal medulla.
Quinlan
P E
PE
Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor 48109-0290.
Alessi
N E
NE
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002846:Chromatography, Affinity; D005260:Female; D007031:Hypothalamus / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D001615:beta-Endorphin / Q000378:metabolism*
D001615:beta-Endorphin