title: Exacerbation of Gilles de la Tourette's syndrome associated with thermal stress: a family study.
abstract: Gilles de la Tourette's syndrome (TS) is a familial disorder that is often exacerbated by stress or fatigue. Here we present a family of a TS proband that has several members with obsessive-compulsive symptoms, a bleeding disorder, and an unusual sensitivity to heat. The proband, who is affected by all of these traits, was challenged with heat or exercise in climate-controlled conditions and showed a marked increase in the frequency of tics.
authors.affiliation: Child Study Center, Yale University, New Haven, CT 06510.
authors.forename: P J
authors.initials: PJ
authors.lastname: Lombroso
authors.forename: G
authors.initials: G
authors.lastname: Mack
authors.forename: L
authors.initials: L
authors.lastname: Scahill
authors.forename: R A
authors.initials: RA
authors.lastname: King
authors.forename: J F
authors.initials: JF
authors.lastname: Leckman
mesh_terms: D000293:Adolescent; D006358:Hot Temperature / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010375:Pedigree; D013312:Stress, Physiological / Q000235:genetics / Q000503:physiopathology*; D005879:Tourette Syndrome / Q000235:genetics / Q000503:physiopathology*