Effects of stress on the growth of a fibrosarcoma in nu/nu and conventional mice.
BALB/c mice subjected to water stress twice daily, between 3 and 7 min at each exposure 3 days before, 5 days after, or 3 days before and 5 days after intradermal Meth A tumour transplantation, showed an increase of tumour size and tumour growth rate compared with that of home cage control (HCC) mice. However, BALB/c mice subjected to water stress 3 days before and 6 days after tumour transplantation showed a decrease of tumour size and tumour growth rate compared with HCC mice. BALB/c mice subjected to 2 min of handling stress daily on days 1 through 5, but not BALB/c mice subjected to handling stress on days 1 through 7 or on days 6 through 7 of tumour growth, showed an increased in tumour size relative to HCC mice. On the other hand, BALB/cBy mice handling stressed on days 1 through 7, but not BALB/cBy mice handling stressed on days 1 through 5 or days 6 through 7 after tumour transplantation, showed a decreased tumour size compared with HCC mice. No effect of stress could be observed when nu/nu BALB/c mice were subjected to water stress 3 days before and 6 days after tumour transplantation. However, BALB/c nu/nu mice pre-injected intraperitoneally with spleen cells from conventional mice had a decreased tumour size and growth rate of the tumour when stressed 3 days before and 6 days after tumour transplantation.
Aarstad
H J
HJ
Institute of Medical Biology, University of Tromsø, Norway.
Seljelid
R
R
D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced / Q000473:pathology*; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors; D014867:Water
D014867:Water; D008748:Methylcholanthrene