Use of even-numbered carbon atom dicarboxylic salts in parenteral nutrition as fuel substrate.
Sebacic acid (C10), a saturated, straight-chain dicarboxylic acid with 10 carbon atoms in disodic salt form, was given intravenously to two groups of healthy male volunteers in order to evaluate its possible use in total parenteral nutrition. The first group, composed of six subjects, received 1000 mg of sebacate as a bolus; six other subjects (second group) received 10 g of sebacate dissolved in 500 mL of double-distilled water at an infusion rate of 3.33 g/h over 3 hours. The serum sebacate data for each subject were analyzed by computer, using biexponential fit corresponding to a 2-compartment open model. The distribution half-life (t1/2) was 0.34 +/- 0.06 hour and the elimination phase was rather rapid (Ke = 2.10 +/- 0.38/h); the volume of the central compartment was 2.79 +/- 0.54 L and the volume of tissue compartment 3.72 +/- 0.14 L. These data showed a good tissue fixation of sebacate. The plasma clearance was evaluated to be 5.96 +/- 2.19 L/h and the renal clearance was 19.22 +/- 10.69 L/h, indicating that a tubular secretion of C10 takes place. The serum concentration of sebacate raised to the maximal value at the end of the infusion (180 minutes), corresponded to 480.50 +/- 43.02 micrograms/mL. Respiratory and metabolic parameters were evaluated by indirect calorimetry from the beginning of the infusion for 210 minutes. The O2 consumption (VO2 mL/min per square meter) remained essentially unchanged throughout the experiment (from 154.3 +/- 28.3 at 0 to 155.3 +/- 39.5 at time 180 minutes).(ABSTRACT TRUNCATED AT 250 WORDS)
Mingrone
G
G
Istituto di Clinica Medica, Università Cattolica S. Cuore, Rome, Italy.
Tacchino
R M
RM
Castagneto
M
M
Finotti
E
E
Greco
A V
AV
D000328:Adult; D001481:Basal Metabolism; D002153:Calorimetry, Indirect; D003652:Decanoic Acids / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D003998:Dicarboxylic Acids; D004734:Energy Metabolism; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D010101:Oxygen Consumption; D010288:Parenteral Nutrition
D003652:Decanoic Acids; D003998:Dicarboxylic Acids; C011107:sebacic acid