title: [Adult type of idiopathic paroxysmal cold hemoglobinuria].
abstract: A 78-year-old female suffered from idiopathic paroxysmal cold hemoglobinuria (PCH). Her symptom occurred immediately after she worked outside in the cold early morning. This case is characterized by the eldest case with non-syphilitic PCH reported in Japan and by the most advanced anemia (Hb 4.2 g/dl) possibly due to prolonged hemolysis after cold exposure. Analysis of the serum revealed positive Donath-Landsteiner antibody of IgG type, which could react to hemolysis not only below 15 degrees C but also at 15-20 degrees C in vitro.
authors.affiliation: Department of Medicine, Shimane Medical University.
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Furuya
authors.forename: K
authors.initials: K
authors.lastname: Notsu
authors.forename: C
authors.initials: C
authors.lastname: Takagi
authors.forename: Y
authors.initials: Y
authors.lastname: Suyama
authors.forename: H
authors.initials: H
authors.lastname: Ishikura
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D003080:Cold Temperature / Q000009:adverse effects*; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000209:etiology* / Q000276:immunology; D006461:Hemolysis; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G