title: Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats.
abstract: The effects of the cholinesterase inhibitors physostigmine and tetrahydroaminoacridine (THA) on memory and performance deficits induced by scopolamine were studied using an operant delayed non-matching to position task. No effect was seen on the performance of rats when treated with either physostigmine (0.1 mg/kg IP) or THA (1 mg/kg IP) alone. However, the performance deficits induced in the task by scopolamine (0.03 mg/kg SC) were reversed by the same doses of the cholinesterase inhibitors.
authors.affiliation: Astra Neuroscience Research Unit, London, UK.
authors.forename: T K
authors.initials: TK
authors.lastname: Murray
authors.forename: A J
authors.initials: AJ
authors.lastname: Cross
authors.forename: A R
authors.initials: AR
authors.lastname: Green
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D012601:Scopolamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D013619:Tacrine / Q000494:pharmacology*
chemical_list: D013619:Tacrine; D010830:Physostigmine; D012601:Scopolamine