Clozapine and jaw dyskinesia: a case report.
No convincing case of tardive dyskinesia has been associated with clozapine. We briefly discuss a case of clozapine-induced reversible initial dyskinesia described in the German literature, and we report a case of jaw dyskinesia in a 49-year-old female schizophrenic. The dyskinesia appeared 2 weeks after the patient started clozapine treatment, did not respond to anticholinergic medication, and has continued for more than 1 year while the patient has remained on clozapine treatment. The patient had taken haloperidol (less than or equal to 5 mg/day) for 5 weeks before starting clozapine treatment. These are the only two cases of dyskinesia associated with clozapine use that are known to us. They raise the possibility that clozapine can induce dyskinesia.
de Leon
J
J
Medical College of Pennsylvania, Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129.
Moral
L
L
Camuñas
C
C
D001712:Biperiden / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced* / Q000188:drug therapy; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*
D001712:Biperiden; D003024:Clozapine