Effect of prostaglandin inhibition by indomethacin on plasma active and inactive renin concentration in men.
The effect of inhibition of prostaglandin synthesis by indomethacin on active renin and on acid-activable inactive renin was studied in nine healthy, sodium-replete men, both at rest and exercise. These volunteers were investigated after pretreatment with placebo or indomethacin, 150 mg daily for 3 days. Indomethacin induced a decrease in active (p = 0.004), total (p less than 0.001), and inactive (p = 0.02) renin at rest recumbent on average by 42, 19, and 8%, respectively, and at rest sitting on average by 45, 15, and 3%, respectively. Inhibition of prostaglandins with indomethacin reduced (p less than 0.001) active and total renin at each level of work load but not (p = 0.32) inactive renin. However, the exercise-induced stimulation (p less than 0.05) of active and total renin still occur during indomethacin. Indomethacin reduced (p less than 0.001) at rest sitting and at maximal exercise the plasma concentrations of immunoreactive prostaglandins E2 by 50 and 54%, respectively, prostaglandin F2 alpha by 36 and 39%, respectively, and 13,14-dihydro-15-keto-prostaglandin F alpha by 38 and 60%, respectively. The urinary excretion of immunoreactive prostaglandin E2 and F2 alpha was also reduced.
Lijnen
P
P
Department of Pathophysiology, University of Leuven, K. U. Leuven, Belgium.
Staessen
J
J
Fagard
R
R
Amery
A
A
D000328:Adult; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011187:Posture / Q000502:physiology; D011453:Prostaglandins / Q000096:biosynthesis*; D012016:Reference Values; D012083:Renin / Q000097:blood*
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D012083:Renin; D007213:Indomethacin