title: Protein crystal growth in microgravity.
abstract: Protein crystallography is a powerful method for determining the three-dimensional structures of biological macromolecules. Although new methods, such as two-dimensional NMR, have demonstrated promise for determining the structures of small proteins and nucleic acids, the complete atomic arrangements within large proteins can only be determined at present using crystallographic techniques. Such crystallographic studies have been of major importance for establishing structure/function relationships that are fundamental to understanding how enzymes, nucleic acids, and other macromolecules function in biological systems. More recently, crystallographic studies of proteins have become of considerable practical interest within the pharmaceutical and biotechnology industries, as promising tools in drug design and in protein engineering.
authors.affiliation: Center for Macromolecular Crystallography, University of Alabama, Birmingham 35294.
authors.forename: C E
authors.initials: CE
authors.lastname: Bugg
authors.forename: L J
authors.initials: LJ
authors.lastname: DeLucas
mesh_terms: D003460:Crystallization; D011506:Proteins / Q000737:chemistry*; D014893:Weightlessness; D014961:X-Ray Diffraction
chemical_list: D011506:Proteins