title: Recurrence of colorectal cancer after sutured and stapled large bowel anastomoses.
abstract: The purpose of this study was to compare surgical stapling and manual suturing techniques with respect to the incidence of tumour recurrence in patients with colorectal cancer: 294 patients undergoing potentially curative resections for colorectal cancer were randomly allocated to receive sutured (n = 142) or stapled (n = 152) anastomoses. The mean (s.e.m.) incidence of tumour recurrence at the end of 24 months was 29.4(4.4) per cent in the sutured group, compared with 19.1(3.9) per cent in the stapled group (P less than 0.05). The corresponding rates for cancer-specific mortality at 24 months were 22.3(4.1) per cent and 10.9(3.0) per cent respectively (P less than 0.01). A multiple regression analysis revealed that the influence of anastomotic technique on recurrence and mortality rate was independent of tumour stage. These results suggest that in colorectal cancer surgery the use of stapling instruments for anastomotic construction could be associated with a reduction in the incidence of recurrence and mortality rate by as much as 50 per cent.
authors.affiliation: University Department of Surgery, Western Infirmary, Glasgow, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Akyol
authors.forename: J R
authors.initials: JR
authors.lastname: McGregor
authors.forename: D J
authors.initials: DJ
authors.lastname: Galloway
authors.forename: G
authors.initials: G
authors.lastname: Murray
authors.forename: W D
authors.initials: WD
authors.lastname: George
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000379:methods; D003110:Colonic Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D009367:Neoplasm Staging; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013528:Surgical Staplers / Q000009:adverse effects*; D013537:Sutures