title: Cancer promotion in a mouse-skin model by a 60-Hz magnetic field: II. Tumor development and immune response.
abstract: This paper describes preliminary findings on the influence of 60-Hz (2-mT) magnetic fields on tumor promotion and co-promotion in the skins of mice. The effect of magnetic fields on natural killer (NK) cell activity in spleen and blood was also examined. Groups of 32 juvenile female mice were exposed to the magnetic field as described in part I. The dorsal skin of all animals was treated with a subthreshold dose of the carcinogen 7,12-dimethyl-benz(a)anthracene (DMBA). One week after the treatment, two groups were sham exposed (group A) or field exposed at 2 mT (group B) 6 h/day for 21 weeks, to test whether the field would act as a tumor promoter. No tumors developed in these two groups of mice. To test whether the magnetic field would modify tumor development by directly affecting tumor growth or by suppressing immune surveillance, two additional groups of mice were treated weekly with the tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA) and then either sham exposed (group C) or field exposed (group D). The time to appearance of tumors was shorter (but not statistically so) in the group exposed to magnetic fields and TPA. Some differences in NK cell activity and spleen size were observed between the sham- and field-exposed groups.
authors.affiliation: Health & Welfare Canada, Ottawa, Ontario.
authors.forename: J R
authors.initials: JR
authors.lastname: McLean
authors.forename: M A
authors.initials: MA
authors.lastname: Stuchly
authors.forename: R E
authors.initials: RE
authors.lastname: Mitchel
authors.forename: D
authors.initials: D
authors.lastname: Wilkinson
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Goddard
authors.forename: D W
authors.initials: DW
authors.lastname: Lecuyer
authors.forename: M
authors.initials: M
authors.lastname: Schunk
authors.forename: E
authors.initials: E
authors.lastname: Callary
authors.forename: D
authors.initials: D
authors.lastname: Morrison
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D004574:Electromagnetic Fields / Q000009:adverse effects*; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate
chemical_list: D002273:Carcinogens; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate