[Comparison of the classical Gibson-Cooke methods and the chloride-sensitive electrode in sweat testing for diagnosis of cystic fibrosis].
In 43 children and adolescents (30 healthy and 13 CF patients) the Quantitative Pilocarpine Iontophoresis Test (QPIT) was compared with the ion-specific electrode. We found an excellent correlation between these two methods (r = 0.93) and no false positive or false negative results. With both procedures the total chloride-ion-concentration in sweat of healthy subjects and patients with CF differed significantly (p less than 0.001). Both, the original Gibson and Cooke-sweat-test (QPIT) and the assessment of chloride with the sensitive electrode are highly reliable procedures for confirming the diagnosis of CF.
Riedler
J
J
Kinderspital Landeskrankenanstalten Salzburg.
Arrer
E
E
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002712:Chlorides / Q000032:analysis*; D003550:Cystic Fibrosis / Q000175:diagnosis*; D004566:Electrodes; D005260:Female; D006801:Humans; D007223:Infant; D007478:Iontophoresis; D008297:Male; D010862:Pilocarpine; D012964:Sodium / Q000032:analysis*; D013542:Sweat / Q000737:chemistry*
D002712:Chlorides; D010862:Pilocarpine; D012964:Sodium
Vergleich zwischen klassischer Gibson-Cooke-Methode und Chlorid-sensitiver Elektrode zur Schweisstestung bei der Diagnose der zystischen Fibrose.