title: X-ray sensitivity of fibroblast cell strains derived from atomic bomb survivors with and without breast cancer.
abstract: Fibroblasts were established in vitro from skin biopsies obtained from 55 women and 1 man with or without breast cancer and with or without exposure to radiations from the atomic bomb (A-bomb) explosion in Hiroshima. The radiosensitivity of these cells was evaluated by clonogenic assays after exposure to X-rays. Dose-response curves were fitted to a multitarget model, S/S0 = A[1-(1-e-D/D0)N]. There was no difference in the means or variances of radiosensitivity between exposed and nonexposed groups, or between groups with and without breast cancer.
authors.affiliation: Department of Genetics, Radiation Effects Research Foundation (RERF), Hiroshima, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ban
authors.forename: R B
authors.initials: RB
authors.lastname: Setlow
authors.forename: H
authors.initials: H
authors.lastname: Ezaki
authors.forename: T
authors.initials: T
authors.lastname: Hiraoka
authors.forename: M
authors.initials: M
authors.lastname: Yamane
authors.forename: M
authors.initials: M
authors.lastname: Nishiki
authors.forename: K
authors.initials: K
authors.lastname: Dohi
mesh_terms: D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology*; D002470:Cell Survival / Q000528:radiation effects*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007564:Japan; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000473:pathology*; D009689:Nuclear Warfare; D011836:Radiation Tolerance; D013534:Survival