title: [Valeriana officinalis and Crataegus oxyacantha: toxicity from repeated administration and pharmacologic investigations].
abstract: The aim of this work is to study the toxicity of Valeriana officinalis and Crataegus oxyacantha after reiterated administrations. The study has been carried on the rat which received 300 and 600 mg/kg/24 h of the drugs for 30 days. During the period of the treatment, animals weight and blood pressure have been measured. On the end of the treatment the animals have been sacrificed. The principal organs have been weighed and in blood samples collected hematological and biochemical parameters have been determined. This work is concerned by pharmacological properties which are related to the two plants. The influence of the drugs on the behaviour, the pain, the intestinal peristalsis and strychnine convulsions are reported.
authors.affiliation: Laboratoire de Pharmacologie et de Toxicologie, Société des Industries Pharmaceutiques de Tunisie, Fondouk Choucha.
authors.forename: B
authors.initials: B
authors.lastname: Fehri
authors.forename: J M
authors.initials: JM
authors.lastname: Aiache
authors.forename: K
authors.initials: K
authors.lastname: Boukef
authors.forename: A
authors.initials: A
authors.lastname: Memmi
authors.forename: B
authors.initials: B
authors.lastname: Hizaoui
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014632:Valerian / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D010276:Parasympatholytics; D010936:Plant Extracts
vernacular_title: Valeriana officinalis et Crataegus oxyacantha: toxicité par administrations réitérées et investigations pharmacologiques.