title: Pericentric inversion of chromosome 5: a possible threat to male fertility?
abstract: Pericentric inversion of chromosome 5 (inv(5)(p12,q13] was diagnosed in two unrelated men with normal phenotype referred for infertility. The spermatogenic damage in these patients may be explained on the basis of the X-Y bivalent behaviour in cases of some balanced structural rearrangements of the chromosomes. The Authors propose a possible negative action of inv(5) in male gamete production and suggest a larger use of the chromosome analysis in the study of male infertility.
authors.affiliation: Laboratorio di Citogenetica, Università di Pisa, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Simi
authors.forename: S
authors.initials: S
authors.lastname: Voliani
authors.forename: S
authors.initials: S
authors.lastname: Rossi
authors.forename: L
authors.initials: L
authors.lastname: Olivieri
authors.forename: F
authors.initials: F
authors.lastname: Menchini Fabris
mesh_terms: D000328:Adult; D007446:Chromosome Inversion; D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic