[Change of T lymphocyte subsets in peripherial blood of children with malnutrition and zinc deficiency].
Sixty children with malnutrition were investigated in this study. The results showed a reduction of serum zinc in moderate and severe cases compared with the mild and normal groups. OKT3+, OKT4+ and OKT8+ cells in peripheral blood of mild malnutrition were significantly decreased in contrast to normal control. The reductive degree of OKT8+ and OKT4+ cells correlated with the severity of malnutrition. OKT8+, OKT4+ and OKT4+/OKT8+ ratio of moderate and severe malnutrition with infection were much lower than those without infection. Our findings suggested that main effective and regulative cells of cell-mediated immunity were impaired. OKT3+ and OKT4+ cells might be used as a sensitive index for early assessment of the immune function in malnutrition children.
Zeng
B
B
Qian
Y
Y
Zheng
D
D
Wu
K
K
Zhou
M
M
Gong
Q
Q
D016516:CD4-CD8 Ratio; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009748:Nutrition Disorders / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D015032:Zinc / Q000172:deficiency*
D015032:Zinc