title: The haemodynamic effects of intermittent haemofiltration in critically ill patients.
abstract: The haemodynamic effects of intermittent high volume venovenous haemofiltration were studied in 13 critically ill patients. The mean negative fluid balance during filtration was 1.21 and the mean duration of treatment 3 h 40 min. The cardiac index fell initially (4.5 +/- 0.2 to 3.8 +/- 0.21/min/m2; p less than 0.05) but then remained stable throughout treatment before returning to baseline at the end of haemofiltration. The mean arterial pressure was unchanged with an increase in the systemic vascular resistance (651 +/- 33 to 765 +/- 65 dyne.s/cm5; p less than 0.05) suggesting that vascular responsiveness is maintained during haemofiltration.
authors.affiliation: Intensive Therapy Unit, Western General Hospital, Edinburgh, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: MacKenzie
authors.forename: G R
authors.initials: GR
authors.lastname: Nimmo
authors.forename: I R
authors.initials: IR
authors.lastname: Armstrong
authors.forename: I S
authors.initials: IS
authors.lastname: Grant
mesh_terms: D058186:Acute Kidney Injury / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D016638:Critical Illness; D005069:Evaluation Studies as Topic; D005260:Female; D006439:Hemodynamics; D006440:Hemofiltration / Q000592:standards*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D013566:Sympathomimetics / Q000008:administration & dosage / Q000627:therapeutic use; D016896:Treatment Outcome; D014882:Water-Electrolyte Balance
chemical_list: D013566:Sympathomimetics