Screening assays for immunologic infertility: a comparison study.
Because the immunobead antisperm antibody test (IBT) is difficult to learn and results are heavily operator-dependent, we compared findings on IBT with those of SpermMAR and SpermCheck in 58 patients to determine whether the latter two tests could demonstrate improved screening ability. Assays performed on both sperm and serum (i.e., direct and indirect) yielded 100% positive predictive values when IBT was used as the standard. Both SpermCheck and SpermMAR are easier to perform, and, as the former has a slightly greater sensitivity, we recommend SpermCheck for the detection of immunologic infertility.
Khoo
D
D
Department of Urology, University of California School of Medicine, San Francisco 94143-0738.
Feigenbaum
S L
SL
McClure
R D
RD
D001323:Autoantibodies / Q000097:blood / Q000378:metabolism; D005069:Evaluation Studies as Topic; D006801:Humans; D007159:Immunologic Tests / Q000706:statistics & numerical data; D007248:Infertility, Male / Q000175:diagnosis* / Q000276:immunology*; D007841:Latex Fixation Tests; D008297:Male; D012397:Rosette Formation; D012661:Semen / Q000276:immunology; D012680:Sensitivity and Specificity; D013094:Spermatozoa / Q000276:immunology
D001323:Autoantibodies