Opsonizing activity of C-reactive protein in phagocytosis of Aspergillus fumigatus conidia by human neutrophils.
In complement-free neutrophil monolayer assays pathological levels of C-reactive protein (CRP) were found to promote greater phagocytosis of metabolically-active conidia of Aspergillus fumigatus than dormant spores. This suggests that metabolically-active conidia bind CRP which facilitates in vitro phagocytosis by human neutrophils.
Richardson
M D
MD
Medical Mycology Unit, University of Glasgow, UK.
Shankland
G S
GS
Gray
C A
CA
D001232:Aspergillus fumigatus / Q000276:immunology*; D002097:C-Reactive Protein / Q000276:immunology*; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000276:immunology; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology*; D010587:Phagocytosis
D009895:Opsonin Proteins; D003165:Complement System Proteins; D002097:C-Reactive Protein