[Experimental basis for the prophylactic use of litonit in acute gastroduodenal erosion and ulcer].
The certain indices of morphofunctional state of the cellular membranes and mass of the stress-competent organs of rats in acute stress and its prophylaxis by means of lithonit--a new native atypical tranquilizer with a neotropic action were studied. The immobilization-cold stress caused a statistically significant adrenal hypertrophy and deep degradation of the thymico-lymphatic system. Prophylactic administration of lithonit for 7 days had a protective action on the organs studied. In prophylactic administration of lithonit, the accumulation of membranotoxic products of peroxide oxydation of lipids reduced considerably.
Fomichev
A A
AA
Dotsenko
A P
AP
Kresiun
V I
VI
Rozhkovskii VIa
D000208:Acute Disease; D000818:Animals; D005753:Gastric Mucosa / Q000187:drug effects / Q000503:physiopathology; D015227:Lipid Peroxidation; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D010437:Peptic Ulcer / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology; D014149:Tranquilizing Agents / Q000494:pharmacology / Q000627:therapeutic use*
D009539:Nicotinic Acids; D014149:Tranquilizing Agents; C041554:litonit
Eksperimental'noe obosnovanie vozmozhnosti profilakticheskogo primeneniia litonita pri ostroi gastroduodenal'noi eŕozii i iazve.