[The contribution of hydrophobic parameter to the study of structure activity relationships. II. Antifungal activity of benzylidene-pyrrols].
The purpose of the present work is the contribution of hydrophobic fragmental constant, molecular connectivity and parachor in the study of the relationship between chemical structure and biological activity. The results obtained in this series of benzylidenes-pyrrols have shown high correlation between these parameters and the antifungal activity of these compounds.
Trinh
V H
VH
Laboratoire de Physique, UFR de Pharmacie, Université Joseph-Fourier Grenoble I, La Tronche, France.
Luu-Duc
C
C
Pitta
I
I
Galdino
S
S
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001597:Benzylidene Compounds / Q000737:chemistry / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D001597:Benzylidene Compounds; D011758:Pyrroles
Contribution des paramètres hydrophobes à l'étude de corrélations structure-activité. II. Activité antifongique des benzylidène-pyrroles.