Antinuclear antibodies in first-degree relatives of patients with polymyositis-dermatomyositis: analysis of the relationship with HLA haplotypes.
Antinuclear antibodies (ANA), as detected by indirect immunofluorescence on HEp-2 cells, have been investigated in five spouses and 41 first-degree relatives of nine probands with polymyositis-dermatomyositis (PM-DM) and in 41 sex- and age-matched controls. ANA were detected in 12 out of the 41 first-degree relatives and in two controls (chi 2 = 6.97; P less than 0.01). HLA typing was done in four out of the nine families; in two of them only, ANA segregated with a haplotype. ANA positivity was not correlated either to sex or to age or to household contact. Our results show that ANA occur in a significant percentage of first-degree relatives of patients with PM-DM. The finding seems to be genetically conditioned.
Valentini
G
G
Department of Medicine, 1st Faculty of Medicine, University of Naples 'Federico II', Italy.
Improta
R D
RD
Resse
M
M
Migliaresi
S
S
Minucci
P B
PB
Tirri
R
R
Farzati
B
B
Tirri
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000378:metabolism*; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003882:Dermatomyositis / Q000235:genetics / Q000276:immunology*; D005192:Family Health; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000235:genetics / Q000276:immunology*
D000974:Antibodies, Antinuclear; D006680:HLA Antigens