title: Evaluation of a method for simultaneous quantification of codeine, ethylmorphine and morphine in blood.
abstract: Codeine, ethylmorphine and morphine are the most commonly detected opiates in forensic blood samples in Norway. A method for the simultaneous quantification of these opiates utilizing solid phase extraction and gas chromatography-mass spectrometry has been evaluated. The detection limits were 0.026 mumol/l for codeine, 0.025 mumol/l for ethylmorphine and 0.032 mumol/l for morphine (corresponding to 7.8, 7.8 and 9.1 micrograms/l, respectively). The analytical variations at concentrations of 1.0 mumol/l codeine, 1.0 mumol/l ethylmorphine and 0.5 mumol/l morphine were less than 5%.
authors.affiliation: National Institute of Forensic Toxicology, Oslo, Norway.
authors.forename: H
authors.initials: H
authors.lastname: Gjerde
authors.forename: U
authors.initials: U
authors.lastname: Fongen
authors.forename: H
authors.initials: H
authors.lastname: Gundersen
authors.forename: A S
authors.initials: AS
authors.lastname: Christophersen
mesh_terms: D003061:Codeine / Q000097:blood*; D005036:Ethylmorphine / Q000097:blood*; D005069:Evaluation Studies as Topic; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009020:Morphine / Q000097:blood*; D011237:Predictive Value of Tests
chemical_list: D009020:Morphine; D005036:Ethylmorphine; D003061:Codeine