In-vivo monitoring of corticomedullary nephrocalcinosis in rats using computerized tomography.
An in-vivo method, computerized tomography (CT), was used to monitor nephrocalcinosis in female rats. CT density data correlated well with renal Ca content measured by atomic absorption spectrophotometry. In-vivo CT measurements revealed that the severity of nephrocalcinosis may change spontaneously with time. Manifest calcifications may exhibit spontaneous regression and are probably affected positively by high dietary Mg, in contrast to increased Ca. It is concluded that CT is a suitable and reliable non-invasive in vivo method to follow up time-dependent alterations in kidney calcifications in rats.
Grimm
P
P
Department of Pharmacology and Toxicology of Nutrition, University of Hohenheim, Stuttgart, Germany.
Nowitzki-Grimm
S
S
Weidenmaier
W
W
Schumacher
K A
KA
Classen
H G
HG
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005260:Female; D007672:Kidney Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D007679:Kidney Medulla / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D008991:Monitoring, Physiologic; D009397:Nephrocalcinosis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D013054:Spectrophotometry, Atomic; D014057:Tomography, X-Ray Computed
D002118:Calcium