title: Parenchymal stress affects interstitial and pleural pressures in in situ lung.
abstract: After resecting the intercostal muscles and thinning the endothoracic fascia, we micropunctured the lung tissue through the intact pleural space at functional residual capacity (FRC) and at volumes above FRC to evaluate the effect of increasing parenchymal stresses on pulmonary interstitial pressure (Pip). Pip was measured at a depth of approximately 230 microns from the pleural surface, at 50% lung height, in 12 anesthetized paralyzed rabbits oxygenated via a tracheal tube with 50% humidified O2. Pip was -10 +/- 1.5 cmH2O at FRC. At alveolar pressure of 5 and 10 cmH2O, lung volume increased by 8.5 and 19 ml and Pip decreased to -12.4 +/- 1.6 and -12.3 +/- 5 cmH2O, respectively. For the same lung volumes held by decreasing pleural surface pressure to about -5 and -8.5 cmH2O, Pip decreased to -17.4 +/- 1.6 and -23.8 +/- 5 cmH2O, respectively. Because Pip is more negative than pleural pressure, the data suggest that in intact pulmonary interstitium the pressure of the liquid phase is primarily set by the mechanisms controlling interstitial fluid turnover.
authors.affiliation: Istituto di Fisiologia Umana, Università degli Studi, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Miserocchi
authors.forename: D
authors.initials: D
authors.lastname: Negrini
authors.forename: C
authors.initials: C
authors.lastname: Gonano
mesh_terms: D000818:Animals; D005652:Functional Residual Capacity / Q000502:physiology; D008168:Lung / Q000502:physiology*; D010994:Pleura / Q000502:physiology*; D011312:Pressure; D011650:Pulmonary Alveoli / Q000502:physiology; D011817:Rabbits; D015656:Respiratory Mechanics / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology