title: The leuprolide flare regime for in-vitro fertilization/gamete intra-fallopian transfer and embryo cryopreservation.
abstract: Gonadotrophin releasing hormone agonists (GnRHa) are now well established as adjuvant agents for in-vitro fertilization (IVF)/gamete intra-Fallopian transfer (GIFT) but several different modes of usage have been proposed. Our experience with 328 cycles of leuprolide used in a flare regime is reviewed. An endocrinologically proven flare effect was associated with a reduction of human menopausal gonadotrophin (HMG) usage (10 versus 16 ampoules) and a lower cycle cancellation/conversion rate (7.4 versus 11.3%). Overall, satisfactory rates of oocyte recovery (93%, mean number of oocytes 7.0), clinical pregnancy (24.4% per oocyte recovery) and pregnancy from frozen/thawed embryo transfers (14%) were achieved. The flare protocol appears to be a satisfactory choice for the majority of subjects but careful monitoring is required to avoid the potential for ovarian hyperstimulation.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Adelaide, Queen Elizabeth Hospital, South Australia.
authors.forename: C D
authors.initials: CD
authors.lastname: Matthews
authors.forename: G M
authors.initials: GM
authors.lastname: Warnes
authors.forename: R J
authors.initials: RJ
authors.lastname: Norman
authors.forename: G
authors.initials: G
authors.lastname: Phillipson
authors.forename: C A
authors.initials: CA
authors.lastname: Kirby
authors.forename: X
authors.initials: X
authors.lastname: Wang
mesh_terms: D015925:Cryopreservation; D004334:Drug Administration Schedule; D004622:Embryo, Mammalian; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D015181:Gamete Intrafallopian Transfer / Q000379:methods*; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage*; D011863:Radioimmunoassay
chemical_list: D016729:Leuprolide