Age-related changes of the effects of a group of nootropic drugs on the content of rat brain biogenic monoamines.
1. The changes in the levels of brain biogenic monoamines (BMAs) after chronic (7 days) treatment with piracetam, aniracetam and structural analogues of aniracetam (p-H, p-F, p-Cl, p-P and m-D) were studied in young and old rats. 2. An age-related significant decrease in the BMA content was established in old rats. 3. Most of the investigated compounds increased the level of one or other BMA in one or other of the brain structures studied. This elevation was predominantly established in old rats. 4. The present results and those from previous behaviour studies show that elevation of one or more of the BMA levels in one or more brain regions plays a beneficial role in the realization of their effects on the processes of learning and memory.
Stancheva
S L
SL
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Petkov
V D
VD
Hadjiivanova
C I
CI
Petkov
V V
VV
D000375:Aging / Q000502:physiology*; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D008297:Male; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D015306:Biogenic Monoamines; D011619:Psychotropic Drugs; D011760:Pyrrolidinones; C036466:aniracetam; D010889:Piracetam