Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.
We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide. The muscle rigidity and hyperpyrexia were unresponsive to intravenous benztropine but resolved within one hour of intravenous dantrolene 2 mg/kg. Within six hours the patient had a partial relapse which resolved completely following further intravenous dantrolene 2 mg/kg. This case demonstrates that the rapid effect of intravenous dantrolene can be life saving in fulminant neuroleptic malignant syndrome.
Henderson
A
A
Intensive Care Unit, Princess Alexandra Hospital, Brisbane, Qld. Australia.
Longdon
P
P
D000368:Aged; D003620:Dantrolene / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008787:Metoclopramide / Q000009:adverse effects*; D009459:Neuroleptic Malignant Syndrome / Q000188:drug therapy* / Q000209:etiology*
D003620:Dantrolene; D008787:Metoclopramide