title: Immunohistochemical localization of basic fibroblast growth factor in ependymal cells of the rat lateral and third ventricles.
abstract: The presence of basic fibroblast growth factor (bFGF) in the third and the lateral ventricular ependyma of the rat has been investigated under the light microscope using a polyclonal antibody against bFGF, through the unlabelled peroxidase-antiperoxidase procedure; bFGF-immunoreactivity (bFGF-IR) is observed in the entire ependymal cell layer of ventricles. Also ependymal tanycytes within the inferior portion of the wall and floor of the third ventricle show bFGF-IR. Tanycytic processes are in close contact with hypothalamic capillaries. The present study strongly suggests that brain ependymal bFGF plays unidentified roles unrelated to its angiogenic or mitogenic capacities.
authors.affiliation: Servicio de Histología, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Cuevas
authors.forename: G
authors.initials: G
authors.lastname: Gimenez-Gallego
authors.forename: R
authors.initials: R
authors.lastname: Martinez-Murillo
authors.forename: F
authors.initials: F
authors.lastname: Carceller
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles / Q000737:chemistry*; D004805:Ependyma / Q000737:chemistry*; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016222:Fibroblast Growth Factor 2