title: [Interim analysis in therapeutic trials: a brief survey of current developments].
abstract: It is often interesting to introduce, in the plan of a clinical trial, the possibility to make interim analyses. However, this induces an increase of type one error and it is thus necessary to use appropriate statistical methods. Usual group sequential procedures are mentioned, just as more recent approaches like flexible methods with free number and time of analyses, or like the succession procedure.
authors.affiliation: INSERM Unité 169, Villejuif.
authors.forename: B
authors.initials: B
authors.lastname: Falissard
authors.forename: J
authors.initials: J
authors.lastname: Lellouch
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D006801:Humans; D013269:Stochastic Processes
vernacular_title: Les analyses intermédiares dans les essais thérapeutiques: un rapide tour d'horizon des nouveaux développements.