Ibuprofen lowers body temperature and metabolic rate of humans with burn injury.
A group of 15 burned children and young adults with large burns (mean, 41% +/- 15% BSA) were administered ibuprofen (40 mg/kg for 3 days). Each patient served as his or her own control in this crossover study (with and without ibuprofen). Paired calorimetric and temperature studies and urinary nitrogen measurements were performed. No nitrogen-sparing effect was identified for this dose of ibuprofen. However, patients demonstrated a statistically significant reduction in average rectal temperature (0.67 degrees C decreases) (p less than 0.01) and in metabolic rate (11.4% decreases) (p less than 0.01) while taking ibuprofen. Linear regression analysis of the reduction in temperature versus the reduction in metabolic rate yielded a statistically significant correlation (p less than 0.01) with a slope of 13.6% reduction in metabolic rate per degree centigrade reduction in the 72-hour average rectal temperature. These results support the hypothesis that ibuprofen attenuates the hypermetabolic response to thermal injury by blunting the temperature elevation that is usually seen.
Wallace
B H
BH
University of Arkansas for Medical Sciences, Little Rock.
Caldwell
F T
FT
Cone
J B
JB
D000293:Adolescent; D001481:Basal Metabolism / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D002056:Burns / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D002151:Calorimetry; D002648:Child; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D009584:Nitrogen / Q000378:metabolism
D009584:Nitrogen; D007052:Ibuprofen