title: Increased ventricular vulnerability in a chronic ethanol model despite reduced electrophysiologic responses to catecholamines.
abstract: An increased incidence of sudden death has been reported in chronic alcoholism. To assess electrical vulnerability of the heart, action potential responses, and the role of the sympathetic system, a well-nourished canine model has been studied intact under chloralose anesthesia after 1 year of ethanol consumption at 36% of caloric intake. Two alcoholic groups were compared with controls (Group 1). In Group 2 myocardial vulnerability was assessed after chronic EtOH and superimposed acute administration. In Group 3 basal vulnerability was related to circulating norepinephrine and release of neurohormone from the myocardium. Subsequently the responsiveness to catecholamine infusion was determined. To assess vulnerability an electrode catheter was placed in the right ventricular apex. The basal ventricular fibrillation threshold (VFT) was reduced to 27 +/- 3 ma in Group 2 versus 43 +/- 1.0 in Group 1. Acute infusion of ethanol in Group 2 further reduced the threshold. Group 3 had a reduced basal VFT. Baseline arterial plasma levels of norepinephrine were 8-fold higher and coronary venous levels 13 times higher in the alcoholic group than in Group 1. However, VFT was not responsive to infused epinephrine, compared with Group 1 controls. In vitro study of superfused ventricular tissue from Group 3 revealed that basal action potential amplitude, overshoot, and resting potential were comparable with normals. Basal repolarization time (90%) was 198 +/- 12 msec in Group 3 versus 215 +/- 6 msec in Group 1 (p less than 0.05). After acute EtOH, repolarization time was shortened to 170 +/- 8.6 in Group 1 at 90 mg% ethanol (p less than 0.002), with minimal further change up to 280 mg%.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103-2714.
authors.forename: R
authors.initials: R
authors.lastname: Patel
authors.forename: J J
authors.initials: JJ
authors.lastname: McArdle
authors.forename: T J
authors.initials: TJ
authors.lastname: Regan
mesh_terms: D000437:Alcoholism / Q000150:complications* / Q000503:physiopathology*; D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D006352:Heart Ventricles / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000503:physiopathology*
chemical_list: D009638:Norepinephrine