title: Rib perichondrial autografts in full-thickness articular cartilage defects in rabbits.
abstract: This study investigated the resurfacing of full-thickness articular defects in the adult rabbit medial femoral condyle using a rib perichondrial graft. The graft was secured to a 4-mm-diameter bone core removed from the femoral condyle. Two postoperative treatment protocols were studied: one group had ad libitum cage activity (CAGE; n = 95) and the other group received two weeks of passive motion (PM; n = 73; eight hours per day, five days per week) followed by cage activity. Animals in both groups were killed at six, 12, 26, and 52 weeks. Repair tissue resembling hyaline cartilage formed in a majority of animals at all time periods and in both postoperative treatment groups. The overall success rates in which repair tissue formed were 58% in the CAGE group and 56% in the PM group. However, over time, a maturation of the neocartilage into nearly normal hyaline articular cartilage was noted with the percentage of Type II collagen increasing from 55% at six weeks to 82% at one year. The complex shear modulus of the repair tissue for both groups became similar to normal cartilage with increased healing time. There was no statistical difference in shear moduli between the two treatment modalities. These results show that cartilage repair tissue derived from rib perichondrium could mature into hyaline articular cartilage over time and would not degrade by one year after repair.
authors.affiliation: Division of Orthopaedics and Rehabilitation, University of California, San Diego.
authors.forename: R D
authors.initials: RD
authors.lastname: Coutts
authors.forename: S L
authors.initials: SL
authors.lastname: Woo
authors.forename: D
authors.initials: D
authors.lastname: Amiel
authors.forename: H P
authors.initials: HP
authors.lastname: von Schroeder
authors.forename: M K
authors.initials: MK
authors.lastname: Kwan
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D003094:Collagen / Q000032:analysis; D005269:Femur / Q000601:surgery; D006025:Glycosaminoglycans / Q000032:analysis; D006595:Hexosamines / Q000032:analysis; D015915:Motion Therapy, Continuous Passive; D011817:Rabbits; D012272:Ribs / Q000637:transplantation*; D013314:Stress, Mechanical; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
chemical_list: D006025:Glycosaminoglycans; D006595:Hexosamines; D003094:Collagen