Potassium substitution via the oral route: does its efficacy depend on the anion of the potassium salt?
In an open, randomized study, we investigated the effect of oral potassium chloride (KCl) and of potassium citrate/bicarbonate (K-cit/bic) in 42 patients with hypokalemia (less than or equal to 3.5 mmol/l). In both groups 80 mmol K+ were administered daily. The parameters examined were serum potassium concentration, acid-base status, and urinary electrolyte excretion. Parameters were evaluated on days 0, 2, 4, and 6. With KCl, [K+] increased from 3.2 +/- 0.2 (mean +/- SD) on day 0 to 3.8 +/- 0.4 mmol/l on day 2 (p less than 0.005) and 4.0 +/- 0.5 mmol/l on day 4 (p less than 0.005). On day 6 [K+] was also 4.0 +/- 0.4 mmol/l (p less than 0.005 vs day 0). With K-cit/bic, [K+] increased from 3.2 +/- 0.2 to 3.7 +/- 0.4 on day 2, 3.9 +/- 0.5 on day 4, and 4.1 +/- 0.6 mmol/l on day 6 (all p less than 0.005 vs day 0). The increase of [K+] was not different between the two groups. Blood pH on day 0 was in the normal range in both groups and did not change significantly during the study. There was a decrease of carbon dioxide partial pressure (pCO2) with KCl from 38.7 +/- 4.9 on day 0 to 36.4 +/- 3.6 on day 2 (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
Meyer-Lehnert
H
H
Medizinische Universitäts-Poliklinik, Bonn.
Evers
W M
WM
Krück
F
F
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001639:Bicarbonates / Q000008:administration & dosage; D002712:Chlorides / Q000097:blood; D002951:Citrates / Q000008:administration & dosage*; D019343:Citric Acid; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011189:Potassium Chloride / Q000008:administration & dosage*; D012964:Sodium / Q000097:blood
D001639:Bicarbonates; D002712:Chlorides; D002951:Citrates; D019343:Citric Acid; D011189:Potassium Chloride; D012964:Sodium; D011188:Potassium