[Effects of lonidamine alone or in combination with radiotherapy on survival and metabolism in human and rodent cell lines].
In vitro investigations on the combined effect of radiation and Lonidamine in one human (LXI) and two rodent cell lines (3T3, V79) showed not a clear radiosensitizing effect. Especially no inhibiting influence on the repair of potentially lethal damage of V79 cells was found. Incubation at lower pH values (6.7 to 6.9) caused no increasing effects. Lonidamine induced damage on the mitochondrial dehydrogenase-system was quantitatively measured with a modified MTT-assay.
Latz
D
D
Radiologische Universitätsklinik, Allgemeine Radiologie und Poliklinik, Heidelberg.
Flentje
M
M
Eble
M
M
Hör
A
A
Wannenmacher
M
M
D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007191:Indazoles / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D051379:Mice; D008928:Mitochondria / Q000201:enzymology; D010088:Oxidoreductases / Q000032:analysis; D011879:Radiotherapy Dosage; D013778:Tetrazolium Salts; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects
D000970:Antineoplastic Agents; D007191:Indazoles; D013778:Tetrazolium Salts; D010088:Oxidoreductases; C016371:lonidamine
Effekte von Lonidamin als Monosubstanz und in Kombination mit Bestrahlung auf Uberleben und Stoffwechsel bei humanen und Nagetierzellinien.