title: Influence of dietary fatty acids on phospholipid composition and prostaglandin E synthesis in rat kidneys.
abstract: The effects of oils with different amounts of n6 and n3 fatty acid precursors and derivatives were evaluated on phospholipid composition and PGE2 synthesis of rat kidneys. Dietary lipids were: olive oil, an olive-blackcurrant-fish oil mixture and a blackcurrant-fish oil mixture. We observed in the kidneys of rats fed the blackcurrant-fish oil mixture a significant decrease in PGE2 synthesis, while arachidonate values did not show significant variations. A decrease of PGE2 synthesis could be due to competitive and inhibitory effects of fatty acids other than arachidonate, observed in the kidney phospholipid composition in our dietary conditions.
authors.affiliation: Centro Ricerche sulla Nutrizione-Dipartimento di Biochimica, Bologna, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Maranesi
authors.forename: V
authors.initials: V
authors.lastname: Barzanti
authors.forename: M
authors.initials: M
authors.lastname: Cocchi
authors.forename: G
authors.initials: G
authors.lastname: Biagi
authors.forename: S
authors.initials: S
authors.lastname: Coccheri
authors.forename: E
authors.initials: E
authors.lastname: Turchetto
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D015232:Dinoprostone / Q000096:biosynthesis*; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D010743:Phospholipids; D016718:Arachidonic Acid; D015232:Dinoprostone