title: Different effects of intracranial and intraorbital section of the optic nerve on the functional responses of rat retinal ganglion cells.
abstract: A lesion to the optic nerve of adult mammals leads to the retrograde degeneration and finally to the death of injured retinal ganglion cells. In this study, we have evaluated the effects induced by different sites of axotomy on the functional changes occurring in the retinal ganglion cells after optic nerve section. We have investigated the functional properties of retinal ganglion cells of adult rats by recording the retinal responses to patterned stimuli (pattern electroretinogram) after unilateral section of the optic nerve at two different levels: intraorbital and intracranial. The results show that the site of lesion of the optic nerve affects the time of disappearance of the pattern electroretinogram. The pattern electroretinogram takes longer to be degraded after an intracranial section than an intraorbital section.
authors.affiliation: Istituto di Neurofisiologia, CNR, Pisa, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Domenici
authors.forename: A
authors.initials: A
authors.lastname: Gravina
authors.forename: N
authors.initials: N
authors.lastname: Berardi
authors.forename: L
authors.initials: L
authors.lastname: Maffei
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D001921:Brain; D004596:Electroretinography; D009410:Nerve Degeneration / Q000502:physiology; D009900:Optic Nerve / Q000033:anatomy & histology / Q000502:physiology*; D009915:Orbit; D051381:Rats; D012165:Retinal Ganglion Cells / Q000502:physiology*