Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis.
The risk of iridocyclitis in children with early onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA) has been shown to be associated with certain HLA haplotypes. Our report contains an actuarial analysis, using one-year intervals, of 161 subjects and estimates haplotype specific risks. Individuals who possess the major susceptibility haplotype HLA-DR5 (11) developed eye disease earlier and with a greater frequency than did those with the protective HLA-DR1 haplotype. Highly significant differences were found between the resulting life-table curves for HLA-DR5 and HLA-DR1 positive subjects (p = 0.00003). These time oriented risk estimates may aid clinicians in determining more precisely the probability of iridocyclitis throughout the course of the disease in children with EOPA-JRA.
Giannini
E H
EH
Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, OH 45229.
Malagon
C N
CN
Van Kerckhove
C
C
Taylor
J
J
Lovell
D J
DJ
Levinson
J E
JE
Passo
M H
MH
Ginsberg
J
J
Burke
M J
MJ
Glass
D N
DN
D000293:Adolescent; D001171:Arthritis, Juvenile / Q000150:complications* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000502:physiology; D006801:Humans; D015863:Iridocyclitis / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics; D015993:Life Tables; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors
D000949:Histocompatibility Antigens Class II