title: Morphological characteristics of the endocrine pancreas in alloxan diabetes after cyclosporin A administration.
abstract: Histological, immunocytochemical, morphometric and electron microscope studies were carried out on the pancreas of alloxan diabetic rats pretreated with cyclosporin A. High mortality, severe destruction of pancreatic B-cells and presence of sporadic mononuclear infiltrations in islets and around excretory ducts were observed. The results obtained show that cyclosporin A potentiates the toxic effect of alloxan on the pancreatic B-cells.
authors.affiliation: Department of Anatomy and Histology, Faculty of Medicine, Bulgarian Academy of Sciences, Sofia.
authors.forename: M
authors.initials: M
authors.lastname: Zafirova
authors.forename: R
authors.initials: R
authors.lastname: Jablenska
authors.forename: A
authors.initials: A
authors.lastname: Popov
authors.forename: I
authors.initials: I
authors.lastname: Goranova
authors.forename: E
authors.initials: E
authors.lastname: Vassileva
authors.forename: J
authors.initials: J
authors.lastname: Duhault
authors.forename: G
authors.initials: G
authors.lastname: Marquie
authors.forename: P
authors.initials: P
authors.lastname: Petkov
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D016572:Cyclosporine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D016572:Cyclosporine