[The efficacy of smectite in acute infantile diarrhea, compared to a placebo and loperamide].
Fifty-six infants (aged 2 months to two years) with moderate to severe diarrhea were entered in a comparative therapeutic trial of smectite versus placebo or loperamide. Results showed that diarrhea resolved faster under smectite than under placebo and at least as fast under smectite as under loperamide. Tolerance of smectite is excellent as a result of the lack of any effect on intestinal motility.
Gilbert
B
B
Service de Pédiatrie I, CHU Dupuytren, Limoges.
Lienhardt
A
A
Palomera
S
S
Barberis
L
L
Borreda
D
D
D003681:Dehydration / Q000517:prevention & control; D003968:Diarrhea, Infantile / Q000188:drug therapy*; D004311:Double-Blind Method; D004361:Drug Tolerance; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008139:Loperamide / Q000627:therapeutic use*; D008297:Male; D010919:Placebos; D017640:Silicates; D013997:Time Factors; D015431:Weight Loss
D005765:Gastrointestinal Agents; D010919:Placebos; D017640:Silicates; D008139:Loperamide; C033214:Smectite
Etude de l'efficacité de la smectite dans les diarrhées aiguës du nourrisson, comparativement à un placebo et au lopéramide.