Vincristine-induced paralytic ileus: role of fiberoptic colonoscopy and prostaglandin F2 alpha.
Two cases of vincristine-induced paralytic ileus are described, with therapeutic correlation. Both patients had a roentgenographic picture of paralytic ileus showing fecal mass in the ascending colon and dilated bowel loops. One patient was successfully treated with glycerin and saline enema through a fiberoptic colonoscope placed in the ascending colon. The second patient was successfully treated with intravenous prostaglandin F2 alpha (PGF2 alpha). Enema through a fiberoptic colonoscope or the intravenous administration of PGF2 alpha may, therefore, prove useful in the treatment of vincristine-induced gastrointestinal toxicity.
Ikehara
O
O
Department of Internal Medicine, Okinawa Chubu Hospital, Japan.
D003112:Colonic Pseudo-Obstruction / Q000139:chemically induced / Q000628:therapy*; D003113:Colonoscopy; D015237:Dinoprost / Q000627:therapeutic use*; D004733:Enema / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014750:Vincristine / Q000009:adverse effects*
D014750:Vincristine; D015237:Dinoprost