title: Disseminated histiocytosis with undetermined Langerhans' cells simulating an acute non lymphoid leukemia.
abstract: The authors report on a case of disseminated Langerhans' cell histiocytosis with a clinical presentation and a bone marrow simulating, at onset, an acute leukemia non lymphoid. A hepatic needle biopsy performed for the progressive enlargement of the liver oriented the diagnosis towards a Langerhans' cell histiocytosis. The morphological, immunohistochemical and ultrastructural study of these cells showed them to be undetermined, i.e. Langerhans' cell precursors.
authors.affiliation: Divisione di Ematologia Pediatrica, Ospedale Bambino Gesù, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Miano
authors.forename: C
authors.initials: C
authors.lastname: Bosman
authors.forename: R
authors.initials: R
authors.lastname: Boldrini
authors.forename: A
authors.initials: A
authors.lastname: DonFrancesco
authors.forename: A
authors.initials: A
authors.lastname: Ceci
authors.forename: S
authors.initials: S
authors.lastname: Mancini
authors.forename: D
authors.initials: D
authors.lastname: Rosati
mesh_terms: D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007223:Infant; D007801:Langerhans Cells / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis*; D008099:Liver / Q000473:pathology