title: Foveal dark adaptation, photopigment regeneration, and aging.
abstract: Foveal dark adaptation in 58 subjects and photopigment regeneration in 60 subjects from 10-78 years of age exhibit parallel slowing of recovery rate with increasing age, with significant correlation of the two functions among individuals. The data are suggestive of an initial slight decline in rate before age 50, followed by a greater decline occurring at different ages in different individuals. Longitudinal data for one subject from age 40-65 show an increase in pigment regeneration time constant consistent with this idea. Foveal sensitivity and photopigment density both decrease with increasing age and are significantly correlated among individuals, although sensitivity declines more with age than does photopigment density. In contrast to earlier proposals based upon the Rushton-Dowling equation, we found no universal constant of proportionality to relate log relative threshold to photopigment within our population.
authors.affiliation: Program in Psychobiology and Neuroscience, Florida State University, Tallahassee.
authors.forename: D C
authors.initials: DC
authors.lastname: Coile
authors.forename: H D
authors.initials: HD
authors.lastname: Baker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002648:Child; D015350:Contrast Sensitivity / Q000502:physiology; D003623:Dark Adaptation; D005584:Fovea Centralis / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D012168:Retinal Pigments / Q000502:physiology*
chemical_list: D012168:Retinal Pigments