title: A phase II study of recombinant tumor necrosis factor in renal cell carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group.
abstract: The National Cancer Institute (NCI) Canada Clinical Trials Group conducted a phase II study of recombinant tumor necrosis factor (rTNF) given intravenously daily for 5 days every other week, in measurable metastatic renal cell carcinoma. Two of 26 patients responded with responses lasting greater than 200 days. Toxicity was severe including rigors, fever, headache, fatigue, hypotension, and localized pain. We conclude that rTNF, given as described, has only modest antitumor activity in renal cell carcinoma and produces considerable toxicity. We plan no further studies of rTNF in this disease.
authors.affiliation: Department of Medical Oncology, London Regional Cancer Centre, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Skillings
authors.forename: R
authors.initials: R
authors.lastname: Wierzbicki
authors.forename: E
authors.initials: E
authors.lastname: Eisenhauer
authors.forename: P
authors.initials: P
authors.lastname: Venner
authors.forename: F
authors.initials: F
authors.lastname: Letendre
authors.forename: D
authors.initials: D
authors.lastname: Stewart
authors.forename: B
authors.initials: B
authors.lastname: Weinerman
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha