title: Epithelioid hemangioendothelioma of the liver: report of two cases.
abstract: Epithelioid hemangioendothelioma is a very rare tumour of vascular origin, the most peculiar feature of which is that it is composed of endothelial cells closely resembling epithelial cells. Confirmation of its endothelial origin is achieved by positive staining for Factor VIII-related antigen or by the demonstration of Weibel-Palade bodies by electron microscopy. We report two cases of primary epithelioid hemangioendothelioma of the liver that occurred in our center in the last ten years. The first patient is a 21 year old woman who presented with a right upper quadrant pain and an echographic finding of multiple hepatic lesions suggestive of metastases. The second patient is a 32 year old woman operated on for a cerebral glioma, in whom an abdominal CT scan, performed in view of radiotherapy, revealed multiple hepatic lesions, originally interpreted as being metastatic. In both cases, diagnosis was made based on the histologic examination of biopsies have been adopted in each case: the first patient has undergone successful liver transplantation. In the second patient an attentive surveillance appeared to be the best option, due to the presence of a previous cerebral glioma.
authors.affiliation: Istituto di Clinica Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Fedeli
authors.forename: M
authors.initials: M
authors.lastname: Certo
authors.forename: O
authors.initials: O
authors.lastname: Cannizzaro
authors.forename: G
authors.initials: G
authors.lastname: Forti
authors.forename: G
authors.initials: G
authors.lastname: Gimbo
authors.forename: R
authors.initials: R
authors.lastname: Abagnale
authors.forename: F M
authors.initials: FM
authors.lastname: Vecchio
mesh_terms: D000328:Adult; D005260:Female; D006390:Hemangioendothelioma / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D011859:Radiography