Improvement in survival of mice with proximal small bowel obstruction treated with octreotide.
Small bowel obstruction is a common disorder in surgical practice. The major morbidity of bowel obstruction relates to intestinal distension and ischemia. We hypothesized that octreotide, a potent inhibitor of gut secretion, would reduce mortality in a mouse model of lethal small bowel obstruction. C57 mice were anesthetized with urethane and prepared with either proximal jejunal or distal ileal obstruction. After 8 hours, surviving mice were randomized to receive either octreotide (100 micrograms/kg) or saline subcutaneously every 8 hours. Octreotide significantly improved survival in mice with proximal obstruction by life table analysis. Mean survival increased from 31 +/- 3 to 41 +/- 4 hours. In distal obstruction, octreotide treatment resulted in a trend towards improved survival; however, this trend failed to reach statistical significance by life table analysis. The improvement in survival in this mouse model suggests that octreotide may be a valuable adjunct in the treatment of patients with small bowel obstruction.
Gittes
G K
GK
Department of Surgery, University of California, San Francisco.
Nelson
M T
MT
Debas
H T
HT
Mulvihill
S J
SJ
D000818:Animals; D007077:Ileal Diseases / Q000188:drug therapy* / Q000401:mortality; D007415:Intestinal Obstruction / Q000188:drug therapy* / Q000401:mortality; D007579:Jejunal Diseases / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D051379:Mice; D015282:Octreotide / Q000627:therapeutic use*
D015282:Octreotide