Mutagenicity studies of kojic acid.
Kojic acid, a fungal metabolite produced by some species of Aspergillus and Penicillium, was found to induce sister chromatid exchanges and chromosomal aberrations in Chinese hamster ovary cells in the presence or absence of the rat liver S9 mix. Furthermore, this compound was demonstrated to induce mutations in Salmonella typhimurium strains TA98 and TA100 using both plate-incorporation and preincubation methods.
Wei
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Food Science and Human Nutrition Department, University of Florida, Gainesville 32611-0163.
Huang
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Fernando
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Chung
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D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D008099:Liver / Q000187:drug effects; D009152:Mutagenicity Tests; D010053:Ovary / Q000187:drug effects; D011753:Pyrones / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D011753:Pyrones; C011890:kojic acid