Studies on the anticonvulsive, sedative and hypothermic effects of Periostracum Cicadae extracts.
The anticonvulsive, sedative and hypothermic effects of water and ethanol extracts of Periostracum Cicadae (PC), the cast off skin of Cryptotympana atrata were studied. The water-extract of whole Periostracum Cicadae (PCws) had anticonvulsive, sedative and hypothermic effects in rats. Orally, it decreased carrageenin-induced hyperthermia. The hypothermic effect of PCws was potentiated by 5-hydroxytryptophan and antagonized by p-chlorophenylalanine. PCws enhanced the decrease in locomotor activity induced by alpha-methyl-p-tyrosine or 5-hydroxytryptophan and reduced the increase in locomotor activity produced by levodopa plus benserazide or p-chlorophenylalanine. From these results, it was concluded that the sedative and hypothermic effect of PCws may be due to an increase in central serotonergic activity.
Hsieh
M T
MT
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan.
Peng
W H
WH
Yeh
F T
FT
Tsai
H Y
HY
Chang
Y S
YS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000633:toxicity*; D000927:Anticonvulsants / Q000302:isolation & purification / Q000633:toxicity*; D001831:Body Temperature / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000302:isolation & purification / Q000633:toxicity*; D007313:Insecta; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D006993:Hypnotics and Sedatives