title: Examination of the role of oxygen free radicals in bronchial asthma in childhood.
abstract: The antioxidant enzyme activities, the lipid peroxidation level, the parameters of glutathione metabolism, and the proportion of haemoglobin oxidation products were determined during the symptom-free period of childhood bronchial asthma. A decreased catalase activity and a significantly reduced glutathione instability were demonstrated as compared to the controls. The results indicate that antioxidant protection of the haemoglobin molecule in asthmatic children is considerably decreased.
authors.affiliation: County and Municipal Children's Hospital, Szeged, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Novák
authors.forename: I
authors.initials: I
authors.lastname: Németh
authors.forename: K
authors.initials: K
authors.lastname: Gyurkovits
authors.forename: S I
authors.initials: SI
authors.lastname: Varga
authors.forename: B
authors.initials: B
authors.lastname: Matkovics
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism; D001249:Asthma / Q000097:blood / Q000201:enzymology / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D005978:Glutathione / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D010100:Oxygen / Q000502:physiology*
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D006454:Hemoglobins; D005978:Glutathione; D010100:Oxygen