title: Heteromorphisms of pericentromeric heterochromatin of chromosome 19.
abstract: The pericentromeric heterochromatin of chromosome 19 exhibits considerable variation even by the G-banding technique. Nevertheless, the C-banding technique has been universally employed to investigate pericentromeric hetromorphisms. We demonstrate that optimal expression of the pericentromeric region can be achieved by using the AluI/G technique. The pericentromeric heterochromatin of chromosome 19 is classified into four classes (I-IV). Fifty normal individuals were evaluated and the incidence of types I-IV were 26%, 17%, 51%, and 6%, respectively. No consistent relationship was observed between the types of heterochromatin identified by the AluI/G technique when compared with the other routinely used procedures.
authors.affiliation: Long Island College Hospital-SUNY Health Science Center, Brooklyn 11201.
authors.forename: R S
authors.initials: RS
authors.lastname: Verma
authors.forename: S
authors.initials: S
authors.lastname: Luke
mesh_terms: D002871:Chromosome Banding; D002888:Chromosomes, Human, Pair 19; D006570:Heterochromatin; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D006570:Heterochromatin