title: T-lymphocyte subsets in nephrotic syndrome.
abstract: T-lymphocyte subsets when measured in steroid responsive nephrotic syndrome (SRNS) have demonstrated significant variance from normal values. T-cell subsets were studied by using two-color flow cytometric analysis in 32 children (9.2 +/- 5 years of age) with SRNS. The children were divided into four groups: a) SRNS in acute relapse, on prednisone; b) SRNS in acute relapse, off prednisone; c) SRNS in long-term remission, off prednisone (nephrotic controls); d) patients in remission on long-term prednisone therapy; and e) 15 age-matched normal controls. Children suffering an acute relapse of SRNS showed an increase in Leu2a+/DR+ (CD8) activated lymphocytes (P less than 0.05), a decrease in Leu4a+ total T-lymphocytes (P = 0.01) and a decrease in Leu3a+ (CD4) helper T-cells (P less than 0.05) when compared to normal controls and nephrotic controls. Though some subset changes may represent a prednisone effect and the functional role of these lymphocytes in the disease process is unknown, this study provides additional evidence to support a role for abnormal T-cell subsets in the etiology of SRNS.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Science, Little Rock.
authors.forename: R T
authors.initials: RT
authors.lastname: Fiser
authors.forename: W C
authors.initials: WC
authors.lastname: Arnold
authors.forename: R K
authors.initials: RK
authors.lastname: Charlton
authors.forename: R W
authors.initials: RW
authors.lastname: Steele
authors.forename: S H
authors.initials: SH
authors.lastname: Childress
authors.forename: B
authors.initials: B
authors.lastname: Shirkey
mesh_terms: D000293:Adolescent; D000943:Antigens, Differentiation; D002648:Child; D002675:Child, Preschool; D005260:Female; D005434:Flow Cytometry; D006684:HLA-DR Antigens; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation; D008297:Male; D009404:Nephrotic Syndrome / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
chemical_list: D000943:Antigens, Differentiation; D006684:HLA-DR Antigens