title: Recurrent aphthous ulceration and food sensitivity.
abstract: Forty patients with recurrent aphthous ulceration (RAU) were investigated to ascertain the possibility of food sensitivity being a significant precipitating factor in their recurrent oral ulceration. All patients were hematologically normal and did not respond to vitamin B1 and B6 therapy. Patch testing (Standard European Series) was undertaken in 21 patients. Twenty patients showed a positive reaction to a number of substances which were considered clinically relevant. Professional advice on avoidance of the allergen was given, resulting in an improvement in eighteen patients. It is concluded that food sensitivity and allergies to other substances should be considered as an etiologic factor in hematologically normal patients with recurrent oral ulceration.
authors.affiliation: Department of Oral Medicine and Pathology, Glasgow Dental Hospital and School, Scotland.
authors.forename: A
authors.initials: A
authors.lastname: Nolan
authors.forename: P J
authors.initials: PJ
authors.lastname: Lamey
authors.forename: K A
authors.initials: KA
authors.lastname: Milligan
authors.forename: A
authors.initials: A
authors.lastname: Forsyth
mesh_terms: D000328:Adult; D000485:Allergens; D004032:Diet; D005260:Female; D005421:Flavoring Agents / Q000494:pharmacology; D005503:Food Additives / Q000494:pharmacology; D005512:Food Hypersensitivity / Q000150:complications* / Q000178:diet therapy; D006801:Humans; D007509:Irritants / Q000494:pharmacology; D008297:Male; D009822:Oils, Volatile / Q000494:pharmacology; D010328:Patch Tests; D011446:Prospective Studies; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000178:diet therapy / Q000209:etiology*
chemical_list: D000485:Allergens; D005421:Flavoring Agents; D005503:Food Additives; D007509:Irritants; D009822:Oils, Volatile