[The interaction of alkylating derivatives of oligodeoxyribonucleotides and their methylphosphonate analogs with Mycoplasma cells].
Alkylating derivatives of decathymidylates and methylphosphonate analogs of oligodeoxyribonucleotides (MPAO) were studied for their interaction with cells of Acholeplasma laidlawii PG-8, Mycoplasma capricolum California Kid, M. pneumoniae FH and phytopathogenic strain (St. 118). It is shown that MPAO of octa- and hexadecathymidylates as well as decathymidylates 3'-terminal modified by phenazine and cholesterol groupings are sorbed by mycoplasma cells and can penetrate inside the cells. Efficiency of binding of alkylating derivatives and MPAO with mycoplasma cells depends on interaction time of reagents, their concentration in the reaction mixture and temperature.
Panchenko
L P
LP
Egorov
O V
OV
Raĭt
A S
AS
Ivanova
E M
EM
Amirkhanov
N V
NV
Zarytova
V F
VF
Vlasov
V V
VV
Skripal'
I G
IG
D000128:Acholeplasma laidlawii / Q000187:drug effects; D000477:Alkylating Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009174:Mycoplasma / Q000187:drug effects*; D009177:Mycoplasma pneumoniae / Q000187:drug effects; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010619:Phenazines / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013696:Temperature; D013997:Time Factors
D000477:Alkylating Agents; D009838:Oligodeoxyribonucleotides; D009943:Organophosphorus Compounds; D010619:Phenazines; C032627:methylphosphonic acid; D002784:Cholesterol
Vzaimodeĭstvie alkiliruiushchikh proizvodnykh oligodezoksiribonukleotidov i ikh metilfosfonatnykh analogov s kletkami mikoplazm.