Report of a variant t(1;15;17)(p36;q22;q21.1) in a patient with acute promyelocytic leukemia.
Chromosome analysis of bone marrow aspirate from a 46-year-old man with acute promyelocytic leukemia (APL) revealed a variant translocation, 46,XY,t(1:15;17)(p36;q22;q21.1). The breakpoints in chromosomes 15 and 17 appear to be the same as those in the more common translocation, t(15;17), associated with APL. The common translocation has been reported in up to 80% of cases of APL. Seventeen cases with variant translocations have been reported involving 15 alone, 17 alone, or 15, 17, and some other chromosome.
Osella
P
P
Center for Human Genetics, Boston University, Massachusetts.
Wyandt
H
H
Vosburgh
E
E
Milunsky
A
A
D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic