title: Management of complex immunogenetics information using an enhanced relational model.
abstract: Flow cytometry has become a technique of paramount importance in the armamentarium of the scientist in such domains as immunogenetics. In the PENGUIN project, we are currently developing the architecture for an expert database system to facilitate the design of flow-cytometry experiments. This paper describes the core of this architecture--a methodology for managing complex biomedical information in an extended relational framework. More specifically, we exploit a semantic data model to enhance relational databases with structuring and manipulation tools that take more domain information into account and provide the user with an appropriate level of abstraction. We present specific applications of the structural model to database schema management, data retrieval and browsing, and integrity maintenance.
authors.affiliation: IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10538.
authors.forename: T
authors.initials: T
authors.lastname: Barsalou
authors.forename: W
authors.initials: W
authors.lastname: Sujansky
authors.forename: L A
authors.initials: LA
authors.lastname: Herzenberg
authors.forename: G
authors.initials: G
authors.lastname: Wiederhold
mesh_terms: D002469:Cell Separation; D003198:Computer Simulation; D003199:Computer Systems; D003628:Database Management Systems; D016208:Databases, Factual; D005103:Expert Systems; D005434:Flow Cytometry; D007125:Immunogenetics; D016247:Information Storage and Retrieval