title: The response of patients with polycystic ovarian disease to human menopausal gonadotropin therapy after ovarian electrocautery or a luteinizing hormone-releasing hormone agonist.
abstract: OBJECTIVE
  To compare the effect of ovarian electrocautery versus an intranasal (IN) luteinizing hormone-releasing hormone agonist (LH-RH-a) in the response of patients with polycystic ovarian disease (PCOD) to human menopausal gonadotropin (hMG) therapy.
  
  
  METHODS
  A prospective study with serial randomization of patients in two groups for treatment with ovarian electrocautery + hMG or LH-RH-a + hMG.
  
  
  METHODS
  A teaching hospital reproductive endocrinology clinic.
  
  
  METHODS
  Thirty-three women with PCOD who failed to conceive after six treatment cycles with hMG.
  
  
  METHODS
  Midcycle and luteal phase endocrinology, ovulation, pregnancy rates (PRs), and miscarriage rates.
  
  
  RESULTS
  There was no difference in the ovulation or PRs between the two groups. However, the number of cycles with multiple dominant follicles, the luteal phase serum testosterone, and the miscarriage rate were lower in the group pretreated with ovarian electrocautery.
  
  
  CONCLUSIONS
  Pretreatment of patients with PCOD with ovarian electrocautery may be a better alternative to IN LH-RH-a therapy for induction of ovulation with hMG.
authors.affiliation: Faculty of Medicine, Safat, Kuwait.
authors.forename: A A
authors.initials: AA
authors.lastname: Gadir
authors.forename: H M
authors.initials: HM
authors.lastname: Alnaser
authors.forename: R S
authors.initials: RS
authors.lastname: Mowafi
authors.forename: R W
authors.initials: RW
authors.lastname: Shaw
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D002064:Buserelin / Q000627:therapeutic use*; D004564:Electrocoagulation; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008596:Menotropins / Q000627:therapeutic use*; D010053:Ovary / Q000601:surgery*; D010060:Ovulation; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000601:surgery; D011247:Pregnancy; D013739:Testosterone / Q000097:blood
chemical_list: D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D008596:Menotropins; D007986:Luteinizing Hormone; D002064:Buserelin