The effect of megestrol acetate on interleukin-1 activity.
The current study investigates the effect of megestrol acetate, a synthetic progestin, on the activity of interleukin-1. Murine thymocytes were suspended in vitro and stimulated with varying concentrations of interleukin-1. [3H]Thymidine uptake was observed as an index of thymocyte proliferation. A dose-dependent increase in [3H]thymidine uptake was observed with increasing concentrations of interleukin-1. When megestrol acetate was added to the solution, a marked suppressive effect was observed. Higher doses of megestrol acetate had a greater suppressive effect on thymocyte proliferation. Additional investigation is required to further delineate the potential systemic effects of megestrol acetate.
Terada
K
K
Department of Obstetrics and Gynecology, University of Hawaii School of Medicine, Honolulu 96822.
Suthum
P A
PA
Katsura
K
K
Hokama
Y
Y
D000818:Animals; D002478:Cells, Cultured; D007375:Interleukin-1 / Q000494:pharmacology / Q000502:physiology*; D007700:Kinetics; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D008535:Megestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D019290:Megestrol Acetate; D051379:Mice; D008807:Mice, Inbred BALB C
D007375:Interleukin-1; D008535:Megestrol; D019290:Megestrol Acetate