Immune-mediated hemolysis associated with the administration of a radiographic contrast medium.
A female patient developed serious hemolysis in association with the injection of a radiographic contrast medium (RCM). Serologic investigation of her serum suggested complement-mediated hemolysis, induced by an RCM-dependent IgM antibody in her serum. The antibody was of high titer and low avidity. The antibody showed cross-reactions with related radiographic contrast media and reacted only with group I adult RBCs.
Nordhagen
R
R
Department of Immunology, National Institute of Public Health, Oslo, Norway.
Vik
H
H
Wolthuis
K
K
Bøhn
H P
HP
Urdahl
P
P
Michaelsen
T E
TE
D003165:Complement System Proteins / Q000276:immunology; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006461:Hemolysis; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D008875:Middle Aged
D003287:Contrast Media; D007075:Immunoglobulin M; D003165:Complement System Proteins