title: Validation of gallium-67-citrate single-photon emission computed tomography in biopsy-confirmed residual Hodgkin's disease in the mediastinum.
abstract: In a retrospective study of a series of 30 adult patients during restaging of Hodgkin's disease after therapy, computed tomography (CT) and biopsy results were correlated with 67Ga SPECT in order to determine the value of SPECT imaging in monitoring recurrent mediastinal Hodgkin's disease. SPECT had an overall accuracy of 93% (28/30) and correctly identified active disease in 24 of 25, 96% of histopathologically proven recurrent Hodgkin's disease. Thus in this post-therapy setting, we have confirmed the high sensitivity of 67GA SPECT scans in patients selected for biopsy. Gallium-67 may prove particularly useful in detecting residual disease activity in patients in whom biopsy was positive but the interpretations of the CT scans were uncertain in regard to presence of tumors [8/30 (27%)]. In this group of patients, we found SPECT particularly helpful. A larger prospective series is under way to assess this possibility.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, New York.
authors.forename: L
authors.initials: L
authors.lastname: Kostakoglu
authors.forename: S D
authors.initials: SD
authors.lastname: Yeh
authors.forename: C
authors.initials: C
authors.lastname: Portlock
authors.forename: R
authors.initials: R
authors.lastname: Heelan
authors.forename: T J
authors.initials: TJ
authors.lastname: Yao
authors.forename: D
authors.initials: D
authors.lastname: Niedzwiecki
authors.forename: S M
authors.initials: SM
authors.lastname: Larson
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005710:Gallium Radioisotopes; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
chemical_list: D005710:Gallium Radioisotopes