Monoclonal antibody BW431/26 labelled with technetium 99m and indium 111: an investigation of the biodistribution and the dosimetry in patients.
As a competitive diagnostic tool for the detection of malignant tumours and other pathological conditions, monoclonal antibodies have long been established. Herein we give the biokinetic data of the antibody BW 431/26 and the consequent radiation dose to patients. These parameters were recorded in 39 patients, using the antibody labelled either with technetium 99m or indium 111. Remarkable differences were observed between the two radionuclides. Whereas the indium-labelled one showed biexponential elimination kinetics, the technetium-labelled one is eliminated linearly over time. The distribution pattern of the two is identical, although the radiation dose varies quite a lot, being 20-fold higher with indium 111 when total body exposure is taken into account (for 111In the whole-body radiation exposure is 0.1 mGy/MBq; for 99mTc it is 0.0047 mGy/MBq). With respect to these results and considering the general availability of the technetium-labelled Ab, it is the best choice for diagnostic use.
Benz
P
P
Abteilung für Nuklearmedizin, Universität des Saarlandes, Homburg, Federal Republic of Germany.
Oberhausen
E
E
Berberich
R
R
D006801:Humans; D007205:Indium Radioisotopes / Q000097:blood / Q000493:pharmacokinetics*; D011829:Radiation Dosage; D016719:Radioimmunodetection; D013667:Technetium / Q000097:blood / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D007205:Indium Radioisotopes; D013667:Technetium